-- dump date 20140619_081637 -- class Genbank::misc_feature -- table misc_feature_note -- id note 595496000001 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 595496000002 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 595496000003 putative catalytic residues [active] 595496000004 putative nucleotide binding site [chemical binding]; other site 595496000005 putative aspartate binding site [chemical binding]; other site 595496000006 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 595496000007 dimer interface [polypeptide binding]; other site 595496000008 putative threonine allosteric regulatory site; other site 595496000009 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 595496000010 putative threonine allosteric regulatory site; other site 595496000011 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 595496000012 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 595496000013 homoserine kinase; Region: thrB; TIGR00191 595496000014 Protein of unknown function; Region: YhfT; pfam10797 595496000015 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 595496000016 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 595496000017 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 595496000018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496000019 catalytic residue [active] 595496000020 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 595496000021 hypothetical protein; Validated; Region: PRK02101 595496000022 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 595496000023 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 595496000024 transaldolase-like protein; Provisional; Region: PTZ00411 595496000025 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 595496000026 active site 595496000027 dimer interface [polypeptide binding]; other site 595496000028 catalytic residue [active] 595496000029 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 595496000030 MPT binding site; other site 595496000031 trimer interface [polypeptide binding]; other site 595496000032 hypothetical protein; Provisional; Region: PRK10659 595496000033 hypothetical protein; Provisional; Region: PRK10236 595496000034 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 595496000035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 595496000036 hypothetical protein; Provisional; Region: PRK10154 595496000037 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 595496000038 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 595496000039 nucleotide binding site [chemical binding]; other site 595496000040 NEF interaction site [polypeptide binding]; other site 595496000041 SBD interface [polypeptide binding]; other site 595496000042 chaperone protein DnaJ; Provisional; Region: PRK10767 595496000043 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 595496000044 HSP70 interaction site [polypeptide binding]; other site 595496000045 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 595496000046 substrate binding site [polypeptide binding]; other site 595496000047 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 595496000048 Zn binding sites [ion binding]; other site 595496000049 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 595496000050 dimer interface [polypeptide binding]; other site 595496000051 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 595496000052 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 595496000053 Hok/gef family; Region: HOK_GEF; pfam01848 595496000054 Hok/gef family; Region: HOK_GEF; pfam01848 595496000055 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 595496000056 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 595496000057 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496000058 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 595496000059 putative dimerization interface [polypeptide binding]; other site 595496000060 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 595496000061 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 595496000062 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 595496000063 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 595496000064 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 595496000065 Protein of unknown function (DUF2575); Region: DUF2575; pfam10837 595496000066 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 595496000067 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 595496000068 active site 595496000069 Riboflavin kinase; Region: Flavokinase; smart00904 595496000070 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 595496000071 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 595496000072 HIGH motif; other site 595496000073 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 595496000074 active site 595496000075 KMSKS motif; other site 595496000076 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 595496000077 tRNA binding surface [nucleotide binding]; other site 595496000078 anticodon binding site; other site 595496000079 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 595496000080 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 595496000081 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 595496000082 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 595496000083 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 595496000084 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 595496000085 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 595496000086 active site 595496000087 tetramer interface [polypeptide binding]; other site 595496000088 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 595496000089 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 595496000090 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 595496000091 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 595496000092 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 595496000093 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 595496000094 catalytic site [active] 595496000095 subunit interface [polypeptide binding]; other site 595496000096 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 595496000097 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 595496000098 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 595496000099 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 595496000100 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 595496000101 ATP-grasp domain; Region: ATP-grasp_4; cl17255 595496000102 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 595496000103 IMP binding site; other site 595496000104 dimer interface [polypeptide binding]; other site 595496000105 interdomain contacts; other site 595496000106 partial ornithine binding site; other site 595496000107 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 595496000108 carnitine operon protein CaiE; Provisional; Region: PRK13627 595496000109 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 595496000110 putative trimer interface [polypeptide binding]; other site 595496000111 putative metal binding site [ion binding]; other site 595496000112 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 595496000113 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 595496000114 substrate binding site [chemical binding]; other site 595496000115 oxyanion hole (OAH) forming residues; other site 595496000116 trimer interface [polypeptide binding]; other site 595496000117 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 595496000118 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 595496000119 acyl-activating enzyme (AAE) consensus motif; other site 595496000120 putative AMP binding site [chemical binding]; other site 595496000121 putative active site [active] 595496000122 putative CoA binding site [chemical binding]; other site 595496000123 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 595496000124 CoA-transferase family III; Region: CoA_transf_3; pfam02515 595496000125 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 595496000126 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 595496000127 active site 595496000128 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 595496000129 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 595496000130 Ligand binding site [chemical binding]; other site 595496000131 Electron transfer flavoprotein domain; Region: ETF; pfam01012 595496000132 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 595496000133 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 595496000134 Ligand binding site [chemical binding]; other site 595496000135 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 595496000136 putative oxidoreductase FixC; Provisional; Region: PRK10157 595496000137 ferredoxin-like protein FixX; Provisional; Region: PRK15449 595496000138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496000139 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 595496000140 putative substrate translocation pore; other site 595496000141 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 595496000142 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 595496000143 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 595496000144 TrkA-N domain; Region: TrkA_N; pfam02254 595496000145 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 595496000146 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 595496000147 folate binding site [chemical binding]; other site 595496000148 NADP+ binding site [chemical binding]; other site 595496000149 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 595496000150 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 595496000151 active site 595496000152 metal binding site [ion binding]; metal-binding site 595496000153 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 595496000154 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 595496000155 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 595496000156 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 595496000157 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 595496000158 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 595496000159 SurA N-terminal domain; Region: SurA_N; pfam09312 595496000160 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 595496000161 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 595496000162 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 595496000163 OstA-like protein; Region: OstA; pfam03968 595496000164 Organic solvent tolerance protein; Region: OstA_C; pfam04453 595496000165 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 595496000166 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 595496000167 putative metal binding site [ion binding]; other site 595496000168 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 595496000169 HSP70 interaction site [polypeptide binding]; other site 595496000170 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 595496000171 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 595496000172 active site 595496000173 ATP-dependent helicase HepA; Validated; Region: PRK04914 595496000174 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 595496000175 ATP binding site [chemical binding]; other site 595496000176 putative Mg++ binding site [ion binding]; other site 595496000177 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 595496000178 nucleotide binding region [chemical binding]; other site 595496000179 ATP-binding site [chemical binding]; other site 595496000180 DNA polymerase II; Reviewed; Region: PRK05762 595496000181 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 595496000182 active site 595496000183 catalytic site [active] 595496000184 substrate binding site [chemical binding]; other site 595496000185 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 595496000186 active site 595496000187 metal-binding site 595496000188 L-arabinose isomerase; Provisional; Region: PRK02929 595496000189 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 595496000190 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 595496000191 trimer interface [polypeptide binding]; other site 595496000192 putative substrate binding site [chemical binding]; other site 595496000193 putative metal binding site [ion binding]; other site 595496000194 ribulokinase; Provisional; Region: PRK04123 595496000195 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 595496000196 N- and C-terminal domain interface [polypeptide binding]; other site 595496000197 active site 595496000198 MgATP binding site [chemical binding]; other site 595496000199 catalytic site [active] 595496000200 metal binding site [ion binding]; metal-binding site 595496000201 carbohydrate binding site [chemical binding]; other site 595496000202 homodimer interface [polypeptide binding]; other site 595496000203 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 595496000204 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 595496000205 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 595496000206 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 595496000207 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 595496000208 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 595496000209 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 595496000210 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 595496000211 Walker A/P-loop; other site 595496000212 ATP binding site [chemical binding]; other site 595496000213 Q-loop/lid; other site 595496000214 ABC transporter signature motif; other site 595496000215 Walker B; other site 595496000216 D-loop; other site 595496000217 H-loop/switch region; other site 595496000218 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 595496000219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496000220 dimer interface [polypeptide binding]; other site 595496000221 conserved gate region; other site 595496000222 putative PBP binding loops; other site 595496000223 ABC-ATPase subunit interface; other site 595496000224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496000225 dimer interface [polypeptide binding]; other site 595496000226 conserved gate region; other site 595496000227 putative PBP binding loops; other site 595496000228 ABC-ATPase subunit interface; other site 595496000229 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 595496000230 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 595496000231 transcriptional regulator SgrR; Provisional; Region: PRK13626 595496000232 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 595496000233 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 595496000234 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496000235 sugar efflux transporter; Region: 2A0120; TIGR00899 595496000236 putative substrate translocation pore; other site 595496000237 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 595496000238 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 595496000239 substrate binding site [chemical binding]; other site 595496000240 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 595496000241 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 595496000242 substrate binding site [chemical binding]; other site 595496000243 ligand binding site [chemical binding]; other site 595496000244 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 595496000245 tartrate dehydrogenase; Region: TTC; TIGR02089 595496000246 2-isopropylmalate synthase; Validated; Region: PRK00915 595496000247 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 595496000248 active site 595496000249 catalytic residues [active] 595496000250 metal binding site [ion binding]; metal-binding site 595496000251 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 595496000252 leu operon leader peptide; Provisional; Region: PRK09925 595496000253 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 595496000254 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496000255 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 595496000256 putative substrate binding pocket [chemical binding]; other site 595496000257 putative dimerization interface [polypeptide binding]; other site 595496000258 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 595496000259 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 595496000260 PYR/PP interface [polypeptide binding]; other site 595496000261 dimer interface [polypeptide binding]; other site 595496000262 TPP binding site [chemical binding]; other site 595496000263 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 595496000264 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 595496000265 TPP-binding site [chemical binding]; other site 595496000266 dimer interface [polypeptide binding]; other site 595496000267 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 595496000268 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 595496000269 putative valine binding site [chemical binding]; other site 595496000270 dimer interface [polypeptide binding]; other site 595496000271 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 595496000272 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 595496000273 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 595496000274 DNA binding site [nucleotide binding] 595496000275 domain linker motif; other site 595496000276 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 595496000277 dimerization interface [polypeptide binding]; other site 595496000278 ligand binding site [chemical binding]; other site 595496000279 mraZ protein; Region: TIGR00242 595496000280 MraZ protein; Region: MraZ; pfam02381 595496000281 MraZ protein; Region: MraZ; pfam02381 595496000282 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 595496000283 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 595496000284 cell division protein FtsL; Provisional; Region: PRK10772 595496000285 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 595496000286 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 595496000287 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 595496000288 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 595496000289 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 595496000290 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 595496000291 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 595496000292 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 595496000293 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 595496000294 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 595496000295 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 595496000296 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 595496000297 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 595496000298 Mg++ binding site [ion binding]; other site 595496000299 putative catalytic motif [active] 595496000300 putative substrate binding site [chemical binding]; other site 595496000301 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 595496000302 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 595496000303 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 595496000304 cell division protein FtsW; Provisional; Region: PRK10774 595496000305 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 595496000306 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 595496000307 active site 595496000308 homodimer interface [polypeptide binding]; other site 595496000309 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 595496000310 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 595496000311 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 595496000312 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 595496000313 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 595496000314 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 595496000315 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 595496000316 cell division protein FtsQ; Provisional; Region: PRK10775 595496000317 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 595496000318 Cell division protein FtsQ; Region: FtsQ; pfam03799 595496000319 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 595496000320 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 595496000321 Cell division protein FtsA; Region: FtsA; pfam14450 595496000322 cell division protein FtsZ; Validated; Region: PRK09330 595496000323 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 595496000324 nucleotide binding site [chemical binding]; other site 595496000325 SulA interaction site; other site 595496000326 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 595496000327 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 595496000328 SecA regulator SecM; Provisional; Region: PRK02943 595496000329 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 595496000330 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 595496000331 SEC-C motif; Region: SEC-C; pfam02810 595496000332 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 595496000333 active site 595496000334 8-oxo-dGMP binding site [chemical binding]; other site 595496000335 nudix motif; other site 595496000336 metal binding site [ion binding]; metal-binding site 595496000337 DNA gyrase inhibitor; Reviewed; Region: PRK00418 595496000338 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 595496000339 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 595496000340 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 595496000341 CoA-binding site [chemical binding]; other site 595496000342 ATP-binding [chemical binding]; other site 595496000343 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 595496000344 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 595496000345 active site 595496000346 type IV pilin biogenesis protein; Provisional; Region: PRK10573 595496000347 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 595496000348 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 595496000349 hypothetical protein; Provisional; Region: PRK10436 595496000350 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 595496000351 Walker A motif; other site 595496000352 ATP binding site [chemical binding]; other site 595496000353 Walker B motif; other site 595496000354 putative major pilin subunit; Provisional; Region: PRK10574 595496000355 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 595496000356 Pilin (bacterial filament); Region: Pilin; pfam00114 595496000357 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 595496000358 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 595496000359 dimerization interface [polypeptide binding]; other site 595496000360 active site 595496000361 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 595496000362 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 595496000363 amidase catalytic site [active] 595496000364 Zn binding residues [ion binding]; other site 595496000365 substrate binding site [chemical binding]; other site 595496000366 regulatory protein AmpE; Provisional; Region: PRK10987 595496000367 aromatic amino acid transporter; Provisional; Region: PRK10238 595496000368 Transcriptional regulators [Transcription]; Region: FadR; COG2186 595496000369 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 595496000370 DNA-binding site [nucleotide binding]; DNA binding site 595496000371 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 595496000372 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 595496000373 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 595496000374 dimer interface [polypeptide binding]; other site 595496000375 TPP-binding site [chemical binding]; other site 595496000376 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 595496000377 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 595496000378 E3 interaction surface; other site 595496000379 lipoyl attachment site [posttranslational modification]; other site 595496000380 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 595496000381 E3 interaction surface; other site 595496000382 lipoyl attachment site [posttranslational modification]; other site 595496000383 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 595496000384 E3 interaction surface; other site 595496000385 lipoyl attachment site [posttranslational modification]; other site 595496000386 e3 binding domain; Region: E3_binding; pfam02817 595496000387 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 595496000388 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 595496000389 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 595496000390 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 595496000391 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 595496000392 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 595496000393 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 595496000394 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 595496000395 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 595496000396 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 595496000397 substrate binding site [chemical binding]; other site 595496000398 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 595496000399 substrate binding site [chemical binding]; other site 595496000400 ligand binding site [chemical binding]; other site 595496000401 hypothetical protein; Provisional; Region: PRK05248 595496000402 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 595496000403 spermidine synthase; Provisional; Region: PRK00811 595496000404 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 595496000405 S-adenosylmethionine binding site [chemical binding]; other site 595496000406 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 595496000407 multicopper oxidase; Provisional; Region: PRK10965 595496000408 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 595496000409 Multicopper oxidase; Region: Cu-oxidase; pfam00394 595496000410 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 595496000411 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 595496000412 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 595496000413 Trp docking motif [polypeptide binding]; other site 595496000414 putative active site [active] 595496000415 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 595496000416 active site 595496000417 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 595496000418 active site clefts [active] 595496000419 zinc binding site [ion binding]; other site 595496000420 dimer interface [polypeptide binding]; other site 595496000421 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 595496000422 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 595496000423 Walker A/P-loop; other site 595496000424 ATP binding site [chemical binding]; other site 595496000425 Q-loop/lid; other site 595496000426 ABC transporter signature motif; other site 595496000427 Walker B; other site 595496000428 D-loop; other site 595496000429 H-loop/switch region; other site 595496000430 inner membrane transport permease; Provisional; Region: PRK15066 595496000431 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 595496000432 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 595496000433 active pocket/dimerization site; other site 595496000434 active site 595496000435 phosphorylation site [posttranslational modification] 595496000436 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 595496000437 putative active site [active] 595496000438 putative metal binding site [ion binding]; other site 595496000439 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 595496000440 tetramerization interface [polypeptide binding]; other site 595496000441 active site 595496000442 Uncharacterized conserved protein [Function unknown]; Region: COG5464 595496000443 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 595496000444 pantoate--beta-alanine ligase; Region: panC; TIGR00018 595496000445 Pantoate-beta-alanine ligase; Region: PanC; cd00560 595496000446 active site 595496000447 ATP-binding site [chemical binding]; other site 595496000448 pantoate-binding site; other site 595496000449 HXXH motif; other site 595496000450 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 595496000451 oligomerization interface [polypeptide binding]; other site 595496000452 active site 595496000453 metal binding site [ion binding]; metal-binding site 595496000454 putative fimbrial-like adhesin protein; Provisional; Region: PRK09723 595496000455 putative fimbrial protein StaF; Provisional; Region: PRK15262 595496000456 putative fimbrial protein StaE; Provisional; Region: PRK15263 595496000457 Fimbrial protein; Region: Fimbrial; cl01416 595496000458 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 595496000459 PapC N-terminal domain; Region: PapC_N; pfam13954 595496000460 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 595496000461 PapC C-terminal domain; Region: PapC_C; pfam13953 595496000462 putative chaperone protein EcpD; Provisional; Region: PRK09926 595496000463 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 595496000464 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 595496000465 Fimbrial protein; Region: Fimbrial; cl01416 595496000466 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 595496000467 catalytic center binding site [active] 595496000468 ATP binding site [chemical binding]; other site 595496000469 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 595496000470 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 595496000471 active site 595496000472 NTP binding site [chemical binding]; other site 595496000473 metal binding triad [ion binding]; metal-binding site 595496000474 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 595496000475 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 595496000476 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 595496000477 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 595496000478 active site 595496000479 nucleotide binding site [chemical binding]; other site 595496000480 HIGH motif; other site 595496000481 KMSKS motif; other site 595496000482 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 595496000483 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 595496000484 2'-5' RNA ligase; Provisional; Region: PRK15124 595496000485 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 595496000486 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 595496000487 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 595496000488 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 595496000489 ATP binding site [chemical binding]; other site 595496000490 putative Mg++ binding site [ion binding]; other site 595496000491 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 595496000492 nucleotide binding region [chemical binding]; other site 595496000493 ATP-binding site [chemical binding]; other site 595496000494 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 595496000495 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 595496000496 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 595496000497 Transglycosylase; Region: Transgly; pfam00912 595496000498 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 595496000499 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 595496000500 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 595496000501 N-terminal plug; other site 595496000502 ligand-binding site [chemical binding]; other site 595496000503 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 595496000504 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 595496000505 Walker A/P-loop; other site 595496000506 ATP binding site [chemical binding]; other site 595496000507 Q-loop/lid; other site 595496000508 ABC transporter signature motif; other site 595496000509 Walker B; other site 595496000510 D-loop; other site 595496000511 H-loop/switch region; other site 595496000512 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 595496000513 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 595496000514 siderophore binding site; other site 595496000515 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 595496000516 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 595496000517 ABC-ATPase subunit interface; other site 595496000518 dimer interface [polypeptide binding]; other site 595496000519 putative PBP binding regions; other site 595496000520 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 595496000521 ABC-ATPase subunit interface; other site 595496000522 dimer interface [polypeptide binding]; other site 595496000523 putative PBP binding regions; other site 595496000524 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 595496000525 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 595496000526 inhibitor-cofactor binding pocket; inhibition site 595496000527 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496000528 catalytic residue [active] 595496000529 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 595496000530 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 595496000531 Cl- selectivity filter; other site 595496000532 Cl- binding residues [ion binding]; other site 595496000533 pore gating glutamate residue; other site 595496000534 dimer interface [polypeptide binding]; other site 595496000535 H+/Cl- coupling transport residue; other site 595496000536 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 595496000537 hypothetical protein; Provisional; Region: PRK10578 595496000538 UPF0126 domain; Region: UPF0126; pfam03458 595496000539 UPF0126 domain; Region: UPF0126; pfam03458 595496000540 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 595496000541 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 595496000542 cobalamin binding residues [chemical binding]; other site 595496000543 putative BtuC binding residues; other site 595496000544 dimer interface [polypeptide binding]; other site 595496000545 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 595496000546 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 595496000547 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 595496000548 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 595496000549 Zn2+ binding site [ion binding]; other site 595496000550 Mg2+ binding site [ion binding]; other site 595496000551 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 595496000552 serine endoprotease; Provisional; Region: PRK10942 595496000553 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 595496000554 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 595496000555 protein binding site [polypeptide binding]; other site 595496000556 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 595496000557 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 595496000558 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 595496000559 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 595496000560 hypothetical protein; Provisional; Region: PRK13677 595496000561 phosphodiesterase YaeI; Provisional; Region: PRK11340 595496000562 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 595496000563 putative active site [active] 595496000564 putative metal binding site [ion binding]; other site 595496000565 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 595496000566 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 595496000567 trimer interface [polypeptide binding]; other site 595496000568 active site 595496000569 substrate binding site [chemical binding]; other site 595496000570 CoA binding site [chemical binding]; other site 595496000571 PII uridylyl-transferase; Provisional; Region: PRK05007 595496000572 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 595496000573 metal binding triad; other site 595496000574 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 595496000575 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 595496000576 Zn2+ binding site [ion binding]; other site 595496000577 Mg2+ binding site [ion binding]; other site 595496000578 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 595496000579 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 595496000580 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 595496000581 active site 595496000582 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 595496000583 rRNA interaction site [nucleotide binding]; other site 595496000584 S8 interaction site; other site 595496000585 putative laminin-1 binding site; other site 595496000586 elongation factor Ts; Provisional; Region: tsf; PRK09377 595496000587 UBA/TS-N domain; Region: UBA; pfam00627 595496000588 Elongation factor TS; Region: EF_TS; pfam00889 595496000589 Elongation factor TS; Region: EF_TS; pfam00889 595496000590 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 595496000591 putative nucleotide binding site [chemical binding]; other site 595496000592 uridine monophosphate binding site [chemical binding]; other site 595496000593 homohexameric interface [polypeptide binding]; other site 595496000594 ribosome recycling factor; Reviewed; Region: frr; PRK00083 595496000595 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 595496000596 hinge region; other site 595496000597 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 595496000598 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 595496000599 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 595496000600 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 595496000601 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 595496000602 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 595496000603 catalytic residue [active] 595496000604 putative FPP diphosphate binding site; other site 595496000605 putative FPP binding hydrophobic cleft; other site 595496000606 dimer interface [polypeptide binding]; other site 595496000607 putative IPP diphosphate binding site; other site 595496000608 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 595496000609 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 595496000610 zinc metallopeptidase RseP; Provisional; Region: PRK10779 595496000611 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 595496000612 active site 595496000613 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 595496000614 protein binding site [polypeptide binding]; other site 595496000615 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 595496000616 putative substrate binding region [chemical binding]; other site 595496000617 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 595496000618 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 595496000619 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 595496000620 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 595496000621 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 595496000622 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 595496000623 Surface antigen; Region: Bac_surface_Ag; pfam01103 595496000624 periplasmic chaperone; Provisional; Region: PRK10780 595496000625 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 595496000626 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 595496000627 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 595496000628 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 595496000629 trimer interface [polypeptide binding]; other site 595496000630 active site 595496000631 UDP-GlcNAc binding site [chemical binding]; other site 595496000632 lipid binding site [chemical binding]; lipid-binding site 595496000633 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 595496000634 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 595496000635 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 595496000636 active site 595496000637 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 595496000638 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 595496000639 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 595496000640 RNA/DNA hybrid binding site [nucleotide binding]; other site 595496000641 active site 595496000642 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 595496000643 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 595496000644 putative active site [active] 595496000645 putative PHP Thumb interface [polypeptide binding]; other site 595496000646 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 595496000647 generic binding surface II; other site 595496000648 generic binding surface I; other site 595496000649 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 595496000650 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 595496000651 lysine decarboxylase LdcC; Provisional; Region: PRK15399 595496000652 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 595496000653 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 595496000654 homodimer interface [polypeptide binding]; other site 595496000655 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496000656 catalytic residue [active] 595496000657 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 595496000658 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 595496000659 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 595496000660 putative metal binding site [ion binding]; other site 595496000661 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 595496000662 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 595496000663 Ligand Binding Site [chemical binding]; other site 595496000664 TilS substrate binding domain; Region: TilS; pfam09179 595496000665 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 595496000666 Rho-binding antiterminator; Provisional; Region: PRK11625 595496000667 hypothetical protein; Provisional; Region: PRK04964 595496000668 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 595496000669 hypothetical protein; Provisional; Region: PRK09256 595496000670 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 595496000671 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 595496000672 NlpE N-terminal domain; Region: NlpE; pfam04170 595496000673 hypothetical protein; Provisional; Region: PRK11479 595496000674 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 595496000675 prolyl-tRNA synthetase; Provisional; Region: PRK09194 595496000676 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 595496000677 dimer interface [polypeptide binding]; other site 595496000678 motif 1; other site 595496000679 active site 595496000680 motif 2; other site 595496000681 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 595496000682 putative deacylase active site [active] 595496000683 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 595496000684 active site 595496000685 motif 3; other site 595496000686 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 595496000687 anticodon binding site; other site 595496000688 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 595496000689 homodimer interaction site [polypeptide binding]; other site 595496000690 cofactor binding site; other site 595496000691 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 595496000692 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 595496000693 lipoprotein, YaeC family; Region: TIGR00363 595496000694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496000695 dimer interface [polypeptide binding]; other site 595496000696 conserved gate region; other site 595496000697 ABC-ATPase subunit interface; other site 595496000698 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 595496000699 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 595496000700 Walker A/P-loop; other site 595496000701 ATP binding site [chemical binding]; other site 595496000702 Q-loop/lid; other site 595496000703 ABC transporter signature motif; other site 595496000704 Walker B; other site 595496000705 D-loop; other site 595496000706 H-loop/switch region; other site 595496000707 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 595496000708 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 595496000709 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 595496000710 active site 595496000711 motif I; other site 595496000712 motif II; other site 595496000713 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 595496000714 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 595496000715 active site 595496000716 catalytic tetrad [active] 595496000717 Transcriptional regulator [Transcription]; Region: LysR; COG0583 595496000718 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496000719 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 595496000720 putative effector binding pocket; other site 595496000721 dimerization interface [polypeptide binding]; other site 595496000722 hypothetical protein; Provisional; Region: PRK05421 595496000723 putative catalytic site [active] 595496000724 putative metal binding site [ion binding]; other site 595496000725 putative phosphate binding site [ion binding]; other site 595496000726 putative catalytic site [active] 595496000727 putative phosphate binding site [ion binding]; other site 595496000728 putative metal binding site [ion binding]; other site 595496000729 Methyltransferase domain; Region: Methyltransf_31; pfam13847 595496000730 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 595496000731 S-adenosylmethionine binding site [chemical binding]; other site 595496000732 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 595496000733 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 595496000734 N-acetyl-D-glucosamine binding site [chemical binding]; other site 595496000735 catalytic residue [active] 595496000736 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 595496000737 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 595496000738 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 595496000739 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 595496000740 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 595496000741 RNA/DNA hybrid binding site [nucleotide binding]; other site 595496000742 active site 595496000743 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 595496000744 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 595496000745 active site 595496000746 catalytic site [active] 595496000747 substrate binding site [chemical binding]; other site 595496000748 C-N hydrolase family amidase; Provisional; Region: PRK10438 595496000749 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 595496000750 putative active site [active] 595496000751 catalytic triad [active] 595496000752 dimer interface [polypeptide binding]; other site 595496000753 multimer interface [polypeptide binding]; other site 595496000754 C-lysozyme inhibitor; Provisional; Region: PRK09993 595496000755 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 595496000756 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 595496000757 active site 595496000758 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 595496000759 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 595496000760 dimer interface [polypeptide binding]; other site 595496000761 active site 595496000762 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 595496000763 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 595496000764 putative active site [active] 595496000765 putative dimer interface [polypeptide binding]; other site 595496000766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 595496000767 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 595496000768 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 595496000769 RelB antitoxin; Region: RelB; pfam04221 595496000770 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 595496000771 NlpC/P60 family; Region: NLPC_P60; pfam00877 595496000772 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 595496000773 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 595496000774 active site 595496000775 DNA polymerase IV; Validated; Region: PRK02406 595496000776 DNA binding site [nucleotide binding] 595496000777 putative antitoxin of the YafO-YafN toxin-antitoxin system; Provisional; Region: PRK09778 595496000778 putative toxin YafO; Provisional; Region: PRK09885 595496000779 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 595496000780 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 595496000781 Coenzyme A binding pocket [chemical binding]; other site 595496000782 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 595496000783 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 595496000784 metal binding site [ion binding]; metal-binding site 595496000785 dimer interface [polypeptide binding]; other site 595496000786 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 595496000787 active site 595496000788 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 595496000789 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 595496000790 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 595496000791 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 595496000792 trimer interface [polypeptide binding]; other site 595496000793 eyelet of channel; other site 595496000794 gamma-glutamyl kinase; Provisional; Region: PRK05429 595496000795 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 595496000796 nucleotide binding site [chemical binding]; other site 595496000797 homotetrameric interface [polypeptide binding]; other site 595496000798 putative phosphate binding site [ion binding]; other site 595496000799 putative allosteric binding site; other site 595496000800 PUA domain; Region: PUA; pfam01472 595496000801 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 595496000802 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 595496000803 putative catalytic cysteine [active] 595496000804 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 595496000805 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 595496000806 Protein of unknown function (DUF987); Region: DUF987; pfam06174 595496000807 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 595496000808 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 595496000809 MPN+ (JAMM) motif; other site 595496000810 Zinc-binding site [ion binding]; other site 595496000811 Antirestriction protein; Region: Antirestrict; pfam03230 595496000812 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 595496000813 Predicted transcriptional regulator [Transcription]; Region: COG2378 595496000814 Domain of unknown function (DUF932); Region: DUF932; pfam06067 595496000815 Predicted GTPase [General function prediction only]; Region: COG3596 595496000816 YfjP GTPase; Region: YfjP; cd11383 595496000817 G1 box; other site 595496000818 GTP/Mg2+ binding site [chemical binding]; other site 595496000819 Switch I region; other site 595496000820 G2 box; other site 595496000821 Switch II region; other site 595496000822 G3 box; other site 595496000823 G4 box; other site 595496000824 G5 box; other site 595496000825 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 595496000826 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496000827 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 595496000828 dimerization interface [polypeptide binding]; other site 595496000829 substrate binding pocket [chemical binding]; other site 595496000830 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 595496000831 Helix-turn-helix domain; Region: HTH_38; pfam13936 595496000832 Integrase core domain; Region: rve; pfam00665 595496000833 Transposase domain (DUF772); Region: DUF772; pfam05598 595496000834 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 595496000835 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 595496000836 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 595496000837 acetaldehyde dehydrogenase; Validated; Region: PRK08300 595496000838 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 595496000839 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 595496000840 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 595496000841 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 595496000842 active site 595496000843 catalytic residues [active] 595496000844 metal binding site [ion binding]; metal-binding site 595496000845 DmpG-like communication domain; Region: DmpG_comm; pfam07836 595496000846 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 595496000847 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496000848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496000849 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 595496000850 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 595496000851 S-formylglutathione hydrolase; Region: PLN02442 595496000852 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 595496000853 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 595496000854 substrate binding site [chemical binding]; other site 595496000855 catalytic Zn binding site [ion binding]; other site 595496000856 NAD binding site [chemical binding]; other site 595496000857 structural Zn binding site [ion binding]; other site 595496000858 dimer interface [polypeptide binding]; other site 595496000859 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 595496000860 putative metal binding site [ion binding]; other site 595496000861 putative homodimer interface [polypeptide binding]; other site 595496000862 putative homotetramer interface [polypeptide binding]; other site 595496000863 putative homodimer-homodimer interface [polypeptide binding]; other site 595496000864 putative allosteric switch controlling residues; other site 595496000865 IS2 repressor TnpA; Reviewed; Region: PRK09413 595496000866 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 595496000867 IS2 transposase TnpB; Reviewed; Region: PRK09409 595496000868 HTH-like domain; Region: HTH_21; pfam13276 595496000869 Integrase core domain; Region: rve; pfam00665 595496000870 Integrase core domain; Region: rve_3; pfam13683 595496000871 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 595496000872 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 595496000873 DXD motif; other site 595496000874 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 595496000875 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 595496000876 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 595496000877 substrate binding pocket [chemical binding]; other site 595496000878 membrane-bound complex binding site; other site 595496000879 hinge residues; other site 595496000880 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 595496000881 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 595496000882 Walker A/P-loop; other site 595496000883 ATP binding site [chemical binding]; other site 595496000884 Q-loop/lid; other site 595496000885 ABC transporter signature motif; other site 595496000886 Walker B; other site 595496000887 D-loop; other site 595496000888 H-loop/switch region; other site 595496000889 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 595496000890 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496000891 dimer interface [polypeptide binding]; other site 595496000892 conserved gate region; other site 595496000893 putative PBP binding loops; other site 595496000894 ABC-ATPase subunit interface; other site 595496000895 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 595496000896 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 595496000897 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 595496000898 dimer interface [polypeptide binding]; other site 595496000899 active site 595496000900 Schiff base residues; other site 595496000901 putative transposase OrfB; Reviewed; Region: PHA02517 595496000902 HTH-like domain; Region: HTH_21; pfam13276 595496000903 Integrase core domain; Region: rve; pfam00665 595496000904 Integrase core domain; Region: rve_2; pfam13333 595496000905 Transposase; Region: HTH_Tnp_1; cl17663 595496000906 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 595496000907 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 595496000908 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 595496000909 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 595496000910 microcin B17 transporter; Reviewed; Region: PRK11098 595496000911 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 595496000912 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 595496000913 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 595496000914 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 595496000915 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 595496000916 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 595496000917 anti-RssB factor; Provisional; Region: PRK10244 595496000918 alkaline phosphatase; Provisional; Region: PRK10518 595496000919 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 595496000920 dimer interface [polypeptide binding]; other site 595496000921 active site 595496000922 hypothetical protein; Provisional; Region: PRK11505 595496000923 psiF repeat; Region: PsiF_repeat; pfam07769 595496000924 psiF repeat; Region: PsiF_repeat; pfam07769 595496000925 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 595496000926 MASE2 domain; Region: MASE2; pfam05230 595496000927 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 595496000928 metal binding site [ion binding]; metal-binding site 595496000929 active site 595496000930 I-site; other site 595496000931 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 595496000932 pyrroline-5-carboxylate reductase; Region: PLN02688 595496000933 hypothetical protein; Validated; Region: PRK00124 595496000934 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 595496000935 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 595496000936 ADP binding site [chemical binding]; other site 595496000937 magnesium binding site [ion binding]; other site 595496000938 putative shikimate binding site; other site 595496000939 hypothetical protein; Provisional; Region: PRK10380 595496000940 hypothetical protein; Provisional; Region: PRK10481 595496000941 hypothetical protein; Provisional; Region: PRK10579 595496000942 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 595496000943 fructokinase; Reviewed; Region: PRK09557 595496000944 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 595496000945 nucleotide binding site [chemical binding]; other site 595496000946 MFS transport protein AraJ; Provisional; Region: PRK10091 595496000947 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496000948 putative substrate translocation pore; other site 595496000949 exonuclease subunit SbcC; Provisional; Region: PRK10246 595496000950 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 595496000951 Walker A/P-loop; other site 595496000952 ATP binding site [chemical binding]; other site 595496000953 Q-loop/lid; other site 595496000954 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 595496000955 ABC transporter signature motif; other site 595496000956 Walker B; other site 595496000957 D-loop; other site 595496000958 H-loop/switch region; other site 595496000959 exonuclease subunit SbcD; Provisional; Region: PRK10966 595496000960 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 595496000961 active site 595496000962 metal binding site [ion binding]; metal-binding site 595496000963 DNA binding site [nucleotide binding] 595496000964 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 595496000965 transcriptional regulator PhoB; Provisional; Region: PRK10161 595496000966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 595496000967 active site 595496000968 phosphorylation site [posttranslational modification] 595496000969 intermolecular recognition site; other site 595496000970 dimerization interface [polypeptide binding]; other site 595496000971 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 595496000972 DNA binding site [nucleotide binding] 595496000973 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 595496000974 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 595496000975 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 595496000976 putative active site [active] 595496000977 heme pocket [chemical binding]; other site 595496000978 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 595496000979 dimer interface [polypeptide binding]; other site 595496000980 phosphorylation site [posttranslational modification] 595496000981 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 595496000982 ATP binding site [chemical binding]; other site 595496000983 Mg2+ binding site [ion binding]; other site 595496000984 G-X-G motif; other site 595496000985 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 595496000986 putative proline-specific permease; Provisional; Region: proY; PRK10580 595496000987 Spore germination protein; Region: Spore_permease; cl17796 595496000988 maltodextrin glucosidase; Provisional; Region: PRK10785 595496000989 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 595496000990 homodimer interface [polypeptide binding]; other site 595496000991 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 595496000992 active site 595496000993 homodimer interface [polypeptide binding]; other site 595496000994 catalytic site [active] 595496000995 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 595496000996 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 595496000997 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 595496000998 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 595496000999 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 595496001000 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 595496001001 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 595496001002 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 595496001003 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 595496001004 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 595496001005 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 595496001006 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 595496001007 Protein export membrane protein; Region: SecD_SecF; pfam02355 595496001008 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 595496001009 active site 595496001010 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 595496001011 hypothetical protein; Provisional; Region: PRK11530 595496001012 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 595496001013 ATP cone domain; Region: ATP-cone; pfam03477 595496001014 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 595496001015 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 595496001016 catalytic motif [active] 595496001017 Zn binding site [ion binding]; other site 595496001018 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 595496001019 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 595496001020 homopentamer interface [polypeptide binding]; other site 595496001021 active site 595496001022 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 595496001023 putative RNA binding site [nucleotide binding]; other site 595496001024 thiamine monophosphate kinase; Provisional; Region: PRK05731 595496001025 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 595496001026 ATP binding site [chemical binding]; other site 595496001027 dimerization interface [polypeptide binding]; other site 595496001028 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 595496001029 tetramer interfaces [polypeptide binding]; other site 595496001030 binuclear metal-binding site [ion binding]; other site 595496001031 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 595496001032 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 595496001033 active site 595496001034 catalytic tetrad [active] 595496001035 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 595496001036 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 595496001037 TPP-binding site; other site 595496001038 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 595496001039 PYR/PP interface [polypeptide binding]; other site 595496001040 dimer interface [polypeptide binding]; other site 595496001041 TPP binding site [chemical binding]; other site 595496001042 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 595496001043 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 595496001044 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 595496001045 substrate binding pocket [chemical binding]; other site 595496001046 chain length determination region; other site 595496001047 substrate-Mg2+ binding site; other site 595496001048 catalytic residues [active] 595496001049 aspartate-rich region 1; other site 595496001050 active site lid residues [active] 595496001051 aspartate-rich region 2; other site 595496001052 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 595496001053 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 595496001054 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 595496001055 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 595496001056 Ligand Binding Site [chemical binding]; other site 595496001057 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 595496001058 active site residue [active] 595496001059 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 595496001060 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 595496001061 conserved cys residue [active] 595496001062 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 595496001063 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 595496001064 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 595496001065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 595496001066 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 595496001067 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496001068 Major Facilitator Superfamily; Region: MFS_1; pfam07690 595496001069 putative substrate translocation pore; other site 595496001070 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 595496001071 UbiA prenyltransferase family; Region: UbiA; pfam01040 595496001072 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 595496001073 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 595496001074 Subunit I/III interface [polypeptide binding]; other site 595496001075 Subunit III/IV interface [polypeptide binding]; other site 595496001076 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 595496001077 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 595496001078 D-pathway; other site 595496001079 Putative ubiquinol binding site [chemical binding]; other site 595496001080 Low-spin heme (heme b) binding site [chemical binding]; other site 595496001081 Putative water exit pathway; other site 595496001082 Binuclear center (heme o3/CuB) [ion binding]; other site 595496001083 K-pathway; other site 595496001084 Putative proton exit pathway; other site 595496001085 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 595496001086 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 595496001087 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 595496001088 muropeptide transporter; Reviewed; Region: ampG; PRK11902 595496001089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496001090 putative substrate translocation pore; other site 595496001091 hypothetical protein; Provisional; Region: PRK11627 595496001092 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 595496001093 transcriptional regulator BolA; Provisional; Region: PRK11628 595496001094 trigger factor; Provisional; Region: tig; PRK01490 595496001095 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 595496001096 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 595496001097 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 595496001098 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 595496001099 oligomer interface [polypeptide binding]; other site 595496001100 active site residues [active] 595496001101 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 595496001102 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 595496001103 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 595496001104 Walker A motif; other site 595496001105 ATP binding site [chemical binding]; other site 595496001106 Walker B motif; other site 595496001107 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 595496001108 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 595496001109 Found in ATP-dependent protease La (LON); Region: LON; smart00464 595496001110 Found in ATP-dependent protease La (LON); Region: LON; smart00464 595496001111 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 595496001112 Walker A motif; other site 595496001113 ATP binding site [chemical binding]; other site 595496001114 Walker B motif; other site 595496001115 arginine finger; other site 595496001116 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 595496001117 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 595496001118 IHF dimer interface [polypeptide binding]; other site 595496001119 IHF - DNA interface [nucleotide binding]; other site 595496001120 periplasmic folding chaperone; Provisional; Region: PRK10788 595496001121 SurA N-terminal domain; Region: SurA_N_3; cl07813 595496001122 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 595496001123 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 595496001124 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 595496001125 active site 595496001126 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 595496001127 Ligand Binding Site [chemical binding]; other site 595496001128 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 595496001129 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 595496001130 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 595496001131 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 595496001132 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 595496001133 active site 595496001134 motif I; other site 595496001135 motif II; other site 595496001136 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 595496001137 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 595496001138 putative DNA binding site [nucleotide binding]; other site 595496001139 putative Zn2+ binding site [ion binding]; other site 595496001140 AsnC family; Region: AsnC_trans_reg; pfam01037 595496001141 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 595496001142 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 595496001143 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 595496001144 Walker A/P-loop; other site 595496001145 ATP binding site [chemical binding]; other site 595496001146 Q-loop/lid; other site 595496001147 ABC transporter signature motif; other site 595496001148 Walker B; other site 595496001149 D-loop; other site 595496001150 H-loop/switch region; other site 595496001151 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 595496001152 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 595496001153 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 595496001154 Walker A/P-loop; other site 595496001155 ATP binding site [chemical binding]; other site 595496001156 Q-loop/lid; other site 595496001157 ABC transporter signature motif; other site 595496001158 Walker B; other site 595496001159 D-loop; other site 595496001160 H-loop/switch region; other site 595496001161 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 595496001162 Nitrogen regulatory protein P-II; Region: P-II; smart00938 595496001163 ammonium transporter; Provisional; Region: PRK10666 595496001164 acyl-CoA thioesterase II; Provisional; Region: PRK10526 595496001165 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 595496001166 active site 595496001167 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 595496001168 catalytic triad [active] 595496001169 dimer interface [polypeptide binding]; other site 595496001170 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 595496001171 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 595496001172 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 595496001173 DNA binding site [nucleotide binding] 595496001174 active site 595496001175 Uncharacterized conserved protein [Function unknown]; Region: COG5507 595496001176 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 595496001177 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 595496001178 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 595496001179 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 595496001180 maltose O-acetyltransferase; Provisional; Region: PRK10092 595496001181 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 595496001182 active site 595496001183 substrate binding site [chemical binding]; other site 595496001184 trimer interface [polypeptide binding]; other site 595496001185 CoA binding site [chemical binding]; other site 595496001186 gene expression modulator; Provisional; Region: PRK10945 595496001187 Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757 595496001188 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 595496001189 Protein export membrane protein; Region: SecD_SecF; cl14618 595496001190 Protein export membrane protein; Region: SecD_SecF; cl14618 595496001191 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 595496001192 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 595496001193 HlyD family secretion protein; Region: HlyD_3; pfam13437 595496001194 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 595496001195 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 595496001196 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 595496001197 hypothetical protein; Provisional; Region: PRK11281 595496001198 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 595496001199 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 595496001200 Mechanosensitive ion channel; Region: MS_channel; pfam00924 595496001201 hypothetical protein; Provisional; Region: PRK11038 595496001202 primosomal replication protein N''; Provisional; Region: PRK10093 595496001203 hypothetical protein; Provisional; Region: PRK10527 595496001204 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 595496001205 active site 595496001206 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 595496001207 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 595496001208 Walker A motif; other site 595496001209 ATP binding site [chemical binding]; other site 595496001210 Walker B motif; other site 595496001211 DNA polymerase III subunit delta'; Validated; Region: PRK08485 595496001212 arginine finger; other site 595496001213 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 595496001214 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 595496001215 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 595496001216 hypothetical protein; Validated; Region: PRK00153 595496001217 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 595496001218 RecR protein; Region: RecR; pfam02132 595496001219 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 595496001220 putative active site [active] 595496001221 putative metal-binding site [ion binding]; other site 595496001222 tetramer interface [polypeptide binding]; other site 595496001223 heat shock protein 90; Provisional; Region: PRK05218 595496001224 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 595496001225 ATP binding site [chemical binding]; other site 595496001226 Mg2+ binding site [ion binding]; other site 595496001227 G-X-G motif; other site 595496001228 adenylate kinase; Reviewed; Region: adk; PRK00279 595496001229 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 595496001230 AMP-binding site [chemical binding]; other site 595496001231 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 595496001232 ferrochelatase; Region: hemH; TIGR00109 595496001233 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 595496001234 C-terminal domain interface [polypeptide binding]; other site 595496001235 active site 595496001236 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 595496001237 active site 595496001238 N-terminal domain interface [polypeptide binding]; other site 595496001239 acetyl esterase; Provisional; Region: PRK10162 595496001240 inosine/guanosine kinase; Provisional; Region: PRK15074 595496001241 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 595496001242 putative cation:proton antiport protein; Provisional; Region: PRK10669 595496001243 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 595496001244 TrkA-N domain; Region: TrkA_N; pfam02254 595496001245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496001246 Major Facilitator Superfamily; Region: MFS_1; pfam07690 595496001247 putative substrate translocation pore; other site 595496001248 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 595496001249 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 595496001250 active site 595496001251 metal binding site [ion binding]; metal-binding site 595496001252 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 595496001253 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 595496001254 putative deacylase active site [active] 595496001255 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 595496001256 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 595496001257 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 595496001258 non-specific DNA binding site [nucleotide binding]; other site 595496001259 salt bridge; other site 595496001260 sequence-specific DNA binding site [nucleotide binding]; other site 595496001261 copper exporting ATPase; Provisional; Region: copA; PRK10671 595496001262 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 595496001263 metal-binding site [ion binding] 595496001264 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 595496001265 metal-binding site [ion binding] 595496001266 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 595496001267 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 595496001268 motif II; other site 595496001269 glutaminase; Reviewed; Region: PRK12356 595496001270 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 595496001271 amino acid transporter; Region: 2A0306; TIGR00909 595496001272 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 595496001273 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 595496001274 DNA binding residues [nucleotide binding] 595496001275 dimer interface [polypeptide binding]; other site 595496001276 copper binding site [ion binding]; other site 595496001277 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 595496001278 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 595496001279 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 595496001280 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 595496001281 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 595496001282 Walker A/P-loop; other site 595496001283 ATP binding site [chemical binding]; other site 595496001284 Q-loop/lid; other site 595496001285 ABC transporter signature motif; other site 595496001286 Walker B; other site 595496001287 D-loop; other site 595496001288 H-loop/switch region; other site 595496001289 Uncharacterized protein family (UPF0014); Region: UPF0014; pfam03649 595496001290 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 595496001291 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 595496001292 oxidoreductase; Provisional; Region: PRK08017 595496001293 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 595496001294 NADP binding site [chemical binding]; other site 595496001295 active site 595496001296 steroid binding site; other site 595496001297 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 595496001298 active site 595496001299 catalytic triad [active] 595496001300 oxyanion hole [active] 595496001301 switch loop; other site 595496001302 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 595496001303 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 595496001304 Walker A/P-loop; other site 595496001305 ATP binding site [chemical binding]; other site 595496001306 Q-loop/lid; other site 595496001307 ABC transporter signature motif; other site 595496001308 Walker B; other site 595496001309 D-loop; other site 595496001310 H-loop/switch region; other site 595496001311 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 595496001312 FtsX-like permease family; Region: FtsX; pfam02687 595496001313 FtsX-like permease family; Region: FtsX; pfam02687 595496001314 PAAR motif; Region: PAAR_motif; cl15808 595496001315 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 595496001316 RHS Repeat; Region: RHS_repeat; pfam05593 595496001317 RHS Repeat; Region: RHS_repeat; pfam05593 595496001318 RHS Repeat; Region: RHS_repeat; pfam05593 595496001319 RHS Repeat; Region: RHS_repeat; pfam05593 595496001320 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 595496001321 RHS Repeat; Region: RHS_repeat; pfam05593 595496001322 RHS Repeat; Region: RHS_repeat; pfam05593 595496001323 RHS protein; Region: RHS; pfam03527 595496001324 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 595496001325 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 595496001326 Predicted ATPase [General function prediction only]; Region: COG2603 595496001327 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 595496001328 active site residue [active] 595496001329 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 595496001330 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496001331 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 595496001332 dimerization interface [polypeptide binding]; other site 595496001333 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 595496001334 ureidoglycolate hydrolase; Provisional; Region: PRK03606 595496001335 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 595496001336 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 595496001337 Bacterial transcriptional regulator; Region: IclR; pfam01614 595496001338 glyoxylate carboligase; Provisional; Region: PRK11269 595496001339 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 595496001340 PYR/PP interface [polypeptide binding]; other site 595496001341 dimer interface [polypeptide binding]; other site 595496001342 TPP binding site [chemical binding]; other site 595496001343 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 595496001344 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 595496001345 TPP-binding site [chemical binding]; other site 595496001346 hydroxypyruvate isomerase; Provisional; Region: PRK09997 595496001347 tartronate semialdehyde reductase; Provisional; Region: PRK15059 595496001348 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 595496001349 nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; Region: SLC-NCS1sbd; cd10323 595496001350 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 595496001351 Na binding site [ion binding]; other site 595496001352 substrate binding site [chemical binding]; other site 595496001353 allantoinase; Provisional; Region: PRK08044 595496001354 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 595496001355 active site 595496001356 putative uracil/xanthine transporter; Provisional; Region: PRK11412 595496001357 glycerate kinase II; Provisional; Region: PRK09932 595496001358 putative allantoin catabolism protein; Region: ura-cupin; TIGR03214 595496001359 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 595496001360 Cupin domain; Region: Cupin_2; cl17218 595496001361 allantoate amidohydrolase; Region: AllC; TIGR03176 595496001362 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 595496001363 active site 595496001364 metal binding site [ion binding]; metal-binding site 595496001365 dimer interface [polypeptide binding]; other site 595496001366 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 595496001367 membrane protein FdrA; Validated; Region: PRK06091 595496001368 CoA binding domain; Region: CoA_binding; pfam02629 595496001369 CoA-ligase; Region: Ligase_CoA; pfam00549 595496001370 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 595496001371 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 595496001372 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 595496001373 putative substrate binding site [chemical binding]; other site 595496001374 nucleotide binding site [chemical binding]; other site 595496001375 nucleotide binding site [chemical binding]; other site 595496001376 homodimer interface [polypeptide binding]; other site 595496001377 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 595496001378 ATP-grasp domain; Region: ATP-grasp; pfam02222 595496001379 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 595496001380 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 595496001381 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 595496001382 putative active site [active] 595496001383 putative metal binding site [ion binding]; other site 595496001384 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 595496001385 substrate binding site [chemical binding]; other site 595496001386 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 595496001387 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 595496001388 active site 595496001389 HIGH motif; other site 595496001390 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 595496001391 KMSKS motif; other site 595496001392 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 595496001393 tRNA binding surface [nucleotide binding]; other site 595496001394 anticodon binding site; other site 595496001395 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 595496001396 ribosome-associated protein; Provisional; Region: PRK11507 595496001397 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 595496001398 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 595496001399 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 595496001400 homodimer interface [polypeptide binding]; other site 595496001401 NADP binding site [chemical binding]; other site 595496001402 substrate binding site [chemical binding]; other site 595496001403 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 595496001404 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 595496001405 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 595496001406 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 595496001407 outer membrane usher protein FimD; Provisional; Region: PRK15198 595496001408 PapC N-terminal domain; Region: PapC_N; pfam13954 595496001409 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 595496001410 PapC C-terminal domain; Region: PapC_C; pfam13953 595496001411 fimbrial-like adhesin; Provisional; Region: fimH; PRK15199 595496001412 fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934 595496001413 transcriptional regulator FimZ; Provisional; Region: PRK09935 595496001414 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 595496001415 active site 595496001416 phosphorylation site [posttranslational modification] 595496001417 intermolecular recognition site; other site 595496001418 dimerization interface [polypeptide binding]; other site 595496001419 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 595496001420 DNA binding residues [nucleotide binding] 595496001421 dimerization interface [polypeptide binding]; other site 595496001422 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 595496001423 Int/Topo IB signature motif; other site 595496001424 Transposase; Region: HTH_Tnp_1; cl17663 595496001425 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 595496001426 putative transposase OrfB; Reviewed; Region: PHA02517 595496001427 HTH-like domain; Region: HTH_21; pfam13276 595496001428 Integrase core domain; Region: rve; pfam00665 595496001429 Integrase core domain; Region: rve_2; pfam13333 595496001430 multidrug efflux protein; Reviewed; Region: emrE; PRK09541 595496001431 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 595496001432 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 595496001433 catalytic residues [active] 595496001434 catalytic nucleophile [active] 595496001435 Recombinase; Region: Recombinase; pfam07508 595496001436 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 595496001437 Defensin propeptide; Region: Defensin_propep; pfam00879 595496001438 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 595496001439 substrate binding site [chemical binding]; other site 595496001440 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 595496001441 hypothetical protein; Provisional; Region: PRK09741 595496001442 prophage protein NinE; Provisional; Region: PRK09689 595496001443 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 595496001444 endodeoxyribonuclease RUS; Reviewed; Region: PRK09786 595496001445 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 595496001446 Transposase domain (DUF772); Region: DUF772; pfam05598 595496001447 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 595496001448 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 595496001449 Lysis protein S; Region: Lysis_S; pfam04971 595496001450 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 595496001451 catalytic residues [active] 595496001452 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 595496001453 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 595496001454 Bor protein; Region: Lambda_Bor; pfam06291 595496001455 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 595496001456 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 595496001457 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 595496001458 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 595496001459 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 595496001460 outer membrane protease; Reviewed; Region: PRK10993 595496001461 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 595496001462 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 595496001463 hypothetical protein; Provisional; Region: PRK09936 595496001464 bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782 595496001465 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 595496001466 TPR motif; other site 595496001467 binding surface 595496001468 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 595496001469 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 595496001470 active site 595496001471 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 595496001472 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 595496001473 sensor kinase CusS; Provisional; Region: PRK09835 595496001474 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 595496001475 dimerization interface [polypeptide binding]; other site 595496001476 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 595496001477 dimer interface [polypeptide binding]; other site 595496001478 phosphorylation site [posttranslational modification] 595496001479 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 595496001480 ATP binding site [chemical binding]; other site 595496001481 Mg2+ binding site [ion binding]; other site 595496001482 G-X-G motif; other site 595496001483 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 595496001484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 595496001485 active site 595496001486 phosphorylation site [posttranslational modification] 595496001487 intermolecular recognition site; other site 595496001488 dimerization interface [polypeptide binding]; other site 595496001489 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 595496001490 DNA binding site [nucleotide binding] 595496001491 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 595496001492 periplasmic copper-binding protein; Provisional; Region: PRK09838 595496001493 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 595496001494 HlyD family secretion protein; Region: HlyD_3; pfam13437 595496001495 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 595496001496 phenylalanine transporter; Provisional; Region: PRK10249 595496001497 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 595496001498 Mechanosensitive ion channel; Region: MS_channel; pfam00924 595496001499 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 595496001500 dimer interface [polypeptide binding]; other site 595496001501 FMN binding site [chemical binding]; other site 595496001502 hypothetical protein; Provisional; Region: PRK10250 595496001503 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 595496001504 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 595496001505 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 595496001506 Hok/gef family; Region: HOK_GEF; pfam01848 595496001507 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 595496001508 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 595496001509 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 595496001510 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 595496001511 outer membrane receptor FepA; Provisional; Region: PRK13524 595496001512 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 595496001513 N-terminal plug; other site 595496001514 ligand-binding site [chemical binding]; other site 595496001515 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 595496001516 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 595496001517 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 595496001518 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 595496001519 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 595496001520 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 595496001521 acyl-activating enzyme (AAE) consensus motif; other site 595496001522 AMP binding site [chemical binding]; other site 595496001523 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 595496001524 LPS O-antigen length regulator; Provisional; Region: PRK10381 595496001525 Chain length determinant protein; Region: Wzz; pfam02706 595496001526 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 595496001527 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 595496001528 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 595496001529 Walker A/P-loop; other site 595496001530 ATP binding site [chemical binding]; other site 595496001531 Q-loop/lid; other site 595496001532 ABC transporter signature motif; other site 595496001533 Walker B; other site 595496001534 D-loop; other site 595496001535 H-loop/switch region; other site 595496001536 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 595496001537 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 595496001538 ABC-ATPase subunit interface; other site 595496001539 dimer interface [polypeptide binding]; other site 595496001540 putative PBP binding regions; other site 595496001541 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 595496001542 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 595496001543 ABC-ATPase subunit interface; other site 595496001544 dimer interface [polypeptide binding]; other site 595496001545 putative PBP binding regions; other site 595496001546 enterobactin exporter EntS; Provisional; Region: PRK10489 595496001547 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496001548 putative substrate translocation pore; other site 595496001549 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 595496001550 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 595496001551 siderophore binding site; other site 595496001552 isochorismate synthase EntC; Provisional; Region: PRK15016 595496001553 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 595496001554 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 595496001555 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 595496001556 acyl-activating enzyme (AAE) consensus motif; other site 595496001557 active site 595496001558 AMP binding site [chemical binding]; other site 595496001559 substrate binding site [chemical binding]; other site 595496001560 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 595496001561 hydrophobic substrate binding pocket; other site 595496001562 Isochorismatase family; Region: Isochorismatase; pfam00857 595496001563 active site 595496001564 conserved cis-peptide bond; other site 595496001565 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 595496001566 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 595496001567 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 595496001568 putative NAD(P) binding site [chemical binding]; other site 595496001569 active site 595496001570 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 595496001571 CoenzymeA binding site [chemical binding]; other site 595496001572 subunit interaction site [polypeptide binding]; other site 595496001573 PHB binding site; other site 595496001574 carbon starvation protein A; Provisional; Region: PRK15015 595496001575 Carbon starvation protein CstA; Region: CstA; pfam02554 595496001576 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 595496001577 Uncharacterized small protein [Function unknown]; Region: COG2879 595496001578 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 595496001579 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 595496001580 putative active site [active] 595496001581 metal binding site [ion binding]; metal-binding site 595496001582 methionine aminotransferase; Validated; Region: PRK09082 595496001583 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 595496001584 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496001585 homodimer interface [polypeptide binding]; other site 595496001586 catalytic residue [active] 595496001587 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 595496001588 ParB-like nuclease domain; Region: ParBc; pfam02195 595496001589 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 595496001590 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 595496001591 Active Sites [active] 595496001592 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 595496001593 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 595496001594 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496001595 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 595496001596 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 595496001597 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 595496001598 dimerization domain [polypeptide binding]; other site 595496001599 dimer interface [polypeptide binding]; other site 595496001600 catalytic residues [active] 595496001601 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 595496001602 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 595496001603 dimer interface [polypeptide binding]; other site 595496001604 decamer (pentamer of dimers) interface [polypeptide binding]; other site 595496001605 catalytic triad [active] 595496001606 peroxidatic and resolving cysteines [active] 595496001607 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 595496001608 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 595496001609 catalytic residue [active] 595496001610 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 595496001611 catalytic residues [active] 595496001612 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 595496001613 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 595496001614 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 595496001615 Ligand Binding Site [chemical binding]; other site 595496001616 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 595496001617 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 595496001618 NAD binding site [chemical binding]; other site 595496001619 catalytic Zn binding site [ion binding]; other site 595496001620 structural Zn binding site [ion binding]; other site 595496001621 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 595496001622 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 595496001623 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 595496001624 B1 nucleotide binding pocket [chemical binding]; other site 595496001625 B2 nucleotide binding pocket [chemical binding]; other site 595496001626 CAS motifs; other site 595496001627 active site 595496001628 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 595496001629 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 595496001630 transmembrane helices; other site 595496001631 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 595496001632 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 595496001633 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 595496001634 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 595496001635 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 595496001636 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 595496001637 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 595496001638 putative active site [active] 595496001639 (T/H)XGH motif; other site 595496001640 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 595496001641 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 595496001642 putative active site [active] 595496001643 heme pocket [chemical binding]; other site 595496001644 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 595496001645 ATP binding site [chemical binding]; other site 595496001646 Mg2+ binding site [ion binding]; other site 595496001647 G-X-G motif; other site 595496001648 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 595496001649 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 595496001650 active site 595496001651 phosphorylation site [posttranslational modification] 595496001652 intermolecular recognition site; other site 595496001653 dimerization interface [polypeptide binding]; other site 595496001654 Transcriptional regulator; Region: CitT; pfam12431 595496001655 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 595496001656 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 595496001657 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 595496001658 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 595496001659 DNA-binding site [nucleotide binding]; DNA binding site 595496001660 RNA-binding motif; other site 595496001661 chromosome condensation membrane protein; Provisional; Region: PRK14196 595496001662 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 595496001663 lipoyl synthase; Provisional; Region: PRK05481 595496001664 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 595496001665 FeS/SAM binding site; other site 595496001666 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 595496001667 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496001668 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 595496001669 substrate binding pocket [chemical binding]; other site 595496001670 dimerization interface [polypeptide binding]; other site 595496001671 lipoate-protein ligase B; Provisional; Region: PRK14342 595496001672 hypothetical protein; Provisional; Region: PRK04998 595496001673 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 595496001674 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 595496001675 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 595496001676 rare lipoprotein A; Provisional; Region: PRK10672 595496001677 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 595496001678 Sporulation related domain; Region: SPOR; pfam05036 595496001679 cell wall shape-determining protein; Provisional; Region: PRK10794 595496001680 penicillin-binding protein 2; Provisional; Region: PRK10795 595496001681 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 595496001682 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 595496001683 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 595496001684 ribosome-associated protein; Provisional; Region: PRK11538 595496001685 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 595496001686 catalytic core [active] 595496001687 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 595496001688 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 595496001689 active site 595496001690 (T/H)XGH motif; other site 595496001691 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 595496001692 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 595496001693 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 595496001694 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 595496001695 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 595496001696 HIGH motif; other site 595496001697 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 595496001698 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 595496001699 active site 595496001700 KMSKS motif; other site 595496001701 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 595496001702 tRNA binding surface [nucleotide binding]; other site 595496001703 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 595496001704 hypothetical protein; Provisional; Region: PRK11032 595496001705 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 595496001706 Sel1-like repeats; Region: SEL1; smart00671 595496001707 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 595496001708 Sel1-like repeats; Region: SEL1; smart00671 595496001709 Sel1-like repeats; Region: SEL1; smart00671 595496001710 Sel1-like repeats; Region: SEL1; smart00671 595496001711 Sel1-like repeats; Region: SEL1; smart00671 595496001712 Sel1-like repeats; Region: SEL1; smart00671 595496001713 Sel1-like repeats; Region: SEL1; smart00671 595496001714 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 595496001715 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 595496001716 HSP70 interaction site [polypeptide binding]; other site 595496001717 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 595496001718 Sel1-like repeats; Region: SEL1; smart00671 595496001719 Sel1-like repeats; Region: SEL1; smart00671 595496001720 Sel1 repeat; Region: Sel1; cl02723 595496001721 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 595496001722 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 595496001723 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 595496001724 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 595496001725 nucleotide binding site [chemical binding]; other site 595496001726 putative NEF/HSP70 interaction site [polypeptide binding]; other site 595496001727 SBD interface [polypeptide binding]; other site 595496001728 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 595496001729 active site 595496001730 tetramer interface [polypeptide binding]; other site 595496001731 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 595496001732 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 595496001733 Walker A/P-loop; other site 595496001734 ATP binding site [chemical binding]; other site 595496001735 Q-loop/lid; other site 595496001736 ABC transporter signature motif; other site 595496001737 Walker B; other site 595496001738 D-loop; other site 595496001739 H-loop/switch region; other site 595496001740 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 595496001741 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496001742 dimer interface [polypeptide binding]; other site 595496001743 conserved gate region; other site 595496001744 putative PBP binding loops; other site 595496001745 ABC-ATPase subunit interface; other site 595496001746 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 595496001747 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496001748 dimer interface [polypeptide binding]; other site 595496001749 conserved gate region; other site 595496001750 putative PBP binding loops; other site 595496001751 ABC-ATPase subunit interface; other site 595496001752 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 595496001753 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 595496001754 substrate binding pocket [chemical binding]; other site 595496001755 membrane-bound complex binding site; other site 595496001756 hinge residues; other site 595496001757 Transposase domain (DUF772); Region: DUF772; pfam05598 595496001758 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 595496001759 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 595496001760 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 595496001761 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 595496001762 putative active site [active] 595496001763 catalytic triad [active] 595496001764 putative dimer interface [polypeptide binding]; other site 595496001765 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 595496001766 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 595496001767 Transporter associated domain; Region: CorC_HlyC; smart01091 595496001768 metal-binding heat shock protein; Provisional; Region: PRK00016 595496001769 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 595496001770 PhoH-like protein; Region: PhoH; pfam02562 595496001771 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 595496001772 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 595496001773 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 595496001774 FeS/SAM binding site; other site 595496001775 TRAM domain; Region: TRAM; pfam01938 595496001776 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 595496001777 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 595496001778 asparagine synthetase B; Provisional; Region: asnB; PRK09431 595496001779 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 595496001780 active site 595496001781 dimer interface [polypeptide binding]; other site 595496001782 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 595496001783 Ligand Binding Site [chemical binding]; other site 595496001784 Molecular Tunnel; other site 595496001785 UMP phosphatase; Provisional; Region: PRK10444 595496001786 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 595496001787 active site 595496001788 motif I; other site 595496001789 motif II; other site 595496001790 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 595496001791 MarR family; Region: MarR; pfam01047 595496001792 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 595496001793 ROK family; Region: ROK; pfam00480 595496001794 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 595496001795 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 595496001796 active site 595496001797 dimer interface [polypeptide binding]; other site 595496001798 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 595496001799 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 595496001800 active site 595496001801 trimer interface [polypeptide binding]; other site 595496001802 allosteric site; other site 595496001803 active site lid [active] 595496001804 hexamer (dimer of trimers) interface [polypeptide binding]; other site 595496001805 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 595496001806 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 595496001807 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 595496001808 active site turn [active] 595496001809 phosphorylation site [posttranslational modification] 595496001810 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 595496001811 HPr interaction site; other site 595496001812 glycerol kinase (GK) interaction site [polypeptide binding]; other site 595496001813 active site 595496001814 phosphorylation site [posttranslational modification] 595496001815 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 595496001816 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 595496001817 active site 595496001818 HIGH motif; other site 595496001819 nucleotide binding site [chemical binding]; other site 595496001820 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 595496001821 KMSKS motif; other site 595496001822 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 595496001823 outer membrane porin, OprD family; Region: OprD; pfam03573 595496001824 YbfN-like lipoprotein; Region: YbfN; pfam13982 595496001825 ferric uptake regulator; Provisional; Region: fur; PRK09462 595496001826 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 595496001827 metal binding site 2 [ion binding]; metal-binding site 595496001828 putative DNA binding helix; other site 595496001829 metal binding site 1 [ion binding]; metal-binding site 595496001830 dimer interface [polypeptide binding]; other site 595496001831 structural Zn2+ binding site [ion binding]; other site 595496001832 ryhB-regulated fur leader peptide; Provisional; Region: PRK14761 595496001833 flavodoxin FldA; Validated; Region: PRK09267 595496001834 LexA regulated protein; Provisional; Region: PRK11675 595496001835 acyl-CoA esterase; Provisional; Region: PRK10673 595496001836 PGAP1-like protein; Region: PGAP1; pfam07819 595496001837 replication initiation regulator SeqA; Provisional; Region: PRK11187 595496001838 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 595496001839 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 595496001840 active site 595496001841 substrate binding site [chemical binding]; other site 595496001842 metal binding site [ion binding]; metal-binding site 595496001843 putrescine transporter; Provisional; Region: potE; PRK10655 595496001844 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 595496001845 ornithine decarboxylase; Provisional; Region: PRK13578 595496001846 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 595496001847 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 595496001848 homodimer interface [polypeptide binding]; other site 595496001849 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496001850 catalytic residue [active] 595496001851 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 595496001852 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 595496001853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 595496001854 active site 595496001855 phosphorylation site [posttranslational modification] 595496001856 intermolecular recognition site; other site 595496001857 dimerization interface [polypeptide binding]; other site 595496001858 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 595496001859 DNA binding site [nucleotide binding] 595496001860 sensor protein KdpD; Provisional; Region: PRK10490 595496001861 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 595496001862 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 595496001863 Ligand Binding Site [chemical binding]; other site 595496001864 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 595496001865 GAF domain; Region: GAF_3; pfam13492 595496001866 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 595496001867 dimer interface [polypeptide binding]; other site 595496001868 phosphorylation site [posttranslational modification] 595496001869 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 595496001870 ATP binding site [chemical binding]; other site 595496001871 Mg2+ binding site [ion binding]; other site 595496001872 G-X-G motif; other site 595496001873 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 595496001874 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 595496001875 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 595496001876 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 595496001877 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 595496001878 PAAR motif; Region: PAAR_motif; cl15808 595496001879 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 595496001880 RHS Repeat; Region: RHS_repeat; pfam05593 595496001881 RHS Repeat; Region: RHS_repeat; pfam05593 595496001882 RHS Repeat; Region: RHS_repeat; pfam05593 595496001883 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 595496001884 RHS Repeat; Region: RHS_repeat; pfam05593 595496001885 RHS Repeat; Region: RHS_repeat; pfam05593 595496001886 RHS protein; Region: RHS; pfam03527 595496001887 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 595496001888 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 595496001889 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 595496001890 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 595496001891 Transposase [DNA replication, recombination, and repair]; Region: COG5433 595496001892 hypothetical protein; Provisional; Region: PRK10167 595496001893 Uncharacterized conserved protein [Function unknown]; Region: COG3272 595496001894 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 595496001895 DNA photolyase; Region: DNA_photolyase; pfam00875 595496001896 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 595496001897 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496001898 putative substrate translocation pore; other site 595496001899 POT family; Region: PTR2; pfam00854 595496001900 Uncharacterized conserved protein [Function unknown]; Region: COG0327 595496001901 metal-binding protein; Provisional; Region: PRK10799 595496001902 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 595496001903 sensor histidine kinase inhibitor, KipI family; Region: TIGR00370 595496001904 biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724 595496001905 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 595496001906 putative active site [active] 595496001907 endonuclease VIII; Provisional; Region: PRK10445 595496001908 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 595496001909 DNA binding site [nucleotide binding] 595496001910 catalytic residue [active] 595496001911 putative catalytic residues [active] 595496001912 H2TH interface [polypeptide binding]; other site 595496001913 intercalation triad [nucleotide binding]; other site 595496001914 substrate specificity determining residue; other site 595496001915 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 595496001916 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 595496001917 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 595496001918 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 595496001919 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 595496001920 Fimbrial protein; Region: Fimbrial; pfam00419 595496001921 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 595496001922 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 595496001923 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 595496001924 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 595496001925 PapC N-terminal domain; Region: PapC_N; pfam13954 595496001926 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 595496001927 PapC C-terminal domain; Region: PapC_C; pfam13953 595496001928 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 595496001929 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 595496001930 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 595496001931 dimer interface [polypeptide binding]; other site 595496001932 active site 595496001933 citrylCoA binding site [chemical binding]; other site 595496001934 NADH binding [chemical binding]; other site 595496001935 cationic pore residues; other site 595496001936 oxalacetate/citrate binding site [chemical binding]; other site 595496001937 coenzyme A binding site [chemical binding]; other site 595496001938 catalytic triad [active] 595496001939 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 595496001940 Iron-sulfur protein interface; other site 595496001941 proximal quinone binding site [chemical binding]; other site 595496001942 SdhD (CybS) interface [polypeptide binding]; other site 595496001943 proximal heme binding site [chemical binding]; other site 595496001944 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 595496001945 SdhC subunit interface [polypeptide binding]; other site 595496001946 proximal heme binding site [chemical binding]; other site 595496001947 cardiolipin binding site; other site 595496001948 Iron-sulfur protein interface; other site 595496001949 proximal quinone binding site [chemical binding]; other site 595496001950 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 595496001951 L-aspartate oxidase; Provisional; Region: PRK06175 595496001952 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 595496001953 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 595496001954 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 595496001955 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 595496001956 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 595496001957 TPP-binding site [chemical binding]; other site 595496001958 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 595496001959 dimer interface [polypeptide binding]; other site 595496001960 PYR/PP interface [polypeptide binding]; other site 595496001961 TPP binding site [chemical binding]; other site 595496001962 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 595496001963 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 595496001964 E3 interaction surface; other site 595496001965 lipoyl attachment site [posttranslational modification]; other site 595496001966 e3 binding domain; Region: E3_binding; pfam02817 595496001967 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 595496001968 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 595496001969 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 595496001970 CoA-ligase; Region: Ligase_CoA; pfam00549 595496001971 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 595496001972 CoA binding domain; Region: CoA_binding; smart00881 595496001973 CoA-ligase; Region: Ligase_CoA; pfam00549 595496001974 DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764 595496001975 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 595496001976 DNA-binding site [nucleotide binding]; DNA binding site 595496001977 UTRA domain; Region: UTRA; pfam07702 595496001978 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 595496001979 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 595496001980 active site 595496001981 phosphorylation site [posttranslational modification] 595496001982 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 595496001983 active site 595496001984 P-loop; other site 595496001985 phosphorylation site [posttranslational modification] 595496001986 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 595496001987 alpha-mannosidase; Provisional; Region: PRK09819 595496001988 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 595496001989 active site 595496001990 metal binding site [ion binding]; metal-binding site 595496001991 catalytic site [active] 595496001992 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 595496001993 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 595496001994 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 595496001995 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 595496001996 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 595496001997 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 595496001998 hypothetical protein; Provisional; Region: PRK10588 595496001999 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 595496002000 active site 595496002001 colicin uptake protein TolQ; Provisional; Region: PRK10801 595496002002 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 595496002003 colicin uptake protein TolR; Provisional; Region: PRK11024 595496002004 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 595496002005 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 595496002006 TolA C-terminal; Region: TolA; pfam06519 595496002007 translocation protein TolB; Provisional; Region: tolB; PRK03629 595496002008 TolB amino-terminal domain; Region: TolB_N; pfam04052 595496002009 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 595496002010 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 595496002011 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 595496002012 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 595496002013 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 595496002014 ligand binding site [chemical binding]; other site 595496002015 tol-pal system protein YbgF; Provisional; Region: PRK10803 595496002016 Tetratricopeptide repeat; Region: TPR_6; pfam13174 595496002017 Tetratricopeptide repeat; Region: TPR_6; pfam13174 595496002018 quinolinate synthetase; Provisional; Region: PRK09375 595496002019 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 595496002020 zinc transporter ZitB; Provisional; Region: PRK03557 595496002021 YbgS-like protein; Region: YbgS; pfam13985 595496002022 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 595496002023 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 595496002024 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 595496002025 catalytic core [active] 595496002026 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 595496002027 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 595496002028 active site 595496002029 catalytic residues [active] 595496002030 galactokinase; Provisional; Region: PRK05101 595496002031 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 595496002032 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 595496002033 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 595496002034 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 595496002035 dimer interface [polypeptide binding]; other site 595496002036 active site 595496002037 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 595496002038 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 595496002039 NAD binding site [chemical binding]; other site 595496002040 homodimer interface [polypeptide binding]; other site 595496002041 active site 595496002042 substrate binding site [chemical binding]; other site 595496002043 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 595496002044 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 595496002045 Walker A/P-loop; other site 595496002046 ATP binding site [chemical binding]; other site 595496002047 Q-loop/lid; other site 595496002048 ABC transporter signature motif; other site 595496002049 Walker B; other site 595496002050 D-loop; other site 595496002051 H-loop/switch region; other site 595496002052 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 595496002053 Walker A/P-loop; other site 595496002054 ATP binding site [chemical binding]; other site 595496002055 Q-loop/lid; other site 595496002056 ABC transporter signature motif; other site 595496002057 Walker B; other site 595496002058 D-loop; other site 595496002059 H-loop/switch region; other site 595496002060 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 595496002061 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 595496002062 molybdenum-pterin binding domain; Region: Mop; TIGR00638 595496002063 TOBE domain; Region: TOBE; pfam03459 595496002064 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 595496002065 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 595496002066 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 595496002067 substrate binding pocket [chemical binding]; other site 595496002068 membrane-bound complex binding site; other site 595496002069 hinge residues; other site 595496002070 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 595496002071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496002072 putative PBP binding loops; other site 595496002073 ABC-ATPase subunit interface; other site 595496002074 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 595496002075 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 595496002076 Walker A/P-loop; other site 595496002077 ATP binding site [chemical binding]; other site 595496002078 Q-loop/lid; other site 595496002079 ABC transporter signature motif; other site 595496002080 Walker B; other site 595496002081 D-loop; other site 595496002082 H-loop/switch region; other site 595496002083 molybdenum-pterin binding domain; Region: Mop; TIGR00638 595496002084 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 595496002085 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 595496002086 motif II; other site 595496002087 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 595496002088 6-phosphogluconolactonase; Provisional; Region: PRK11028 595496002089 Transcriptional regulator [Transcription]; Region: LysR; COG0583 595496002090 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496002091 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 595496002092 putative dimerization interface [polypeptide binding]; other site 595496002093 PrpF protein; Region: PrpF; pfam04303 595496002094 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 595496002095 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 595496002096 transmembrane helices; other site 595496002097 putative hydratase; Provisional; Region: PRK11413 595496002098 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 595496002099 substrate binding site [chemical binding]; other site 595496002100 ligand binding site [chemical binding]; other site 595496002101 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 595496002102 substrate binding site [chemical binding]; other site 595496002103 acyl-CoA thioesterase; Provisional; Region: PRK10531 595496002104 putative pectinesterase; Region: PLN02432; cl01911 595496002105 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 595496002106 substrate binding site [chemical binding]; other site 595496002107 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 595496002108 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 595496002109 inhibitor-cofactor binding pocket; inhibition site 595496002110 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496002111 catalytic residue [active] 595496002112 biotin synthase; Provisional; Region: PRK15108 595496002113 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 595496002114 FeS/SAM binding site; other site 595496002115 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 595496002116 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 595496002117 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 595496002118 substrate-cofactor binding pocket; other site 595496002119 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496002120 catalytic residue [active] 595496002121 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 595496002122 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 595496002123 S-adenosylmethionine binding site [chemical binding]; other site 595496002124 AAA domain; Region: AAA_26; pfam13500 595496002125 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 595496002126 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 595496002127 ADP binding site [chemical binding]; other site 595496002128 excinuclease ABC subunit B; Provisional; Region: PRK05298 595496002129 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 595496002130 ATP binding site [chemical binding]; other site 595496002131 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 595496002132 nucleotide binding region [chemical binding]; other site 595496002133 ATP-binding site [chemical binding]; other site 595496002134 Ultra-violet resistance protein B; Region: UvrB; pfam12344 595496002135 UvrB/uvrC motif; Region: UVR; pfam02151 595496002136 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 595496002137 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 595496002138 putative substrate binding pocket [chemical binding]; other site 595496002139 dimer interface [polypeptide binding]; other site 595496002140 phosphate binding site [ion binding]; other site 595496002141 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 595496002142 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 595496002143 FeS/SAM binding site; other site 595496002144 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 595496002145 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 595496002146 MPT binding site; other site 595496002147 trimer interface [polypeptide binding]; other site 595496002148 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 595496002149 trimer interface [polypeptide binding]; other site 595496002150 dimer interface [polypeptide binding]; other site 595496002151 putative active site [active] 595496002152 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 595496002153 MoaE interaction surface [polypeptide binding]; other site 595496002154 MoeB interaction surface [polypeptide binding]; other site 595496002155 thiocarboxylated glycine; other site 595496002156 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 595496002157 MoaE homodimer interface [polypeptide binding]; other site 595496002158 MoaD interaction [polypeptide binding]; other site 595496002159 active site residues [active] 595496002160 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 595496002161 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 595496002162 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 595496002163 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 595496002164 Predicted integral membrane protein [Function unknown]; Region: COG0392 595496002165 cardiolipin synthase 2; Provisional; Region: PRK11263 595496002166 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 595496002167 putative active site [active] 595496002168 catalytic site [active] 595496002169 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 595496002170 putative active site [active] 595496002171 catalytic site [active] 595496002172 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 595496002173 putative catalytic site [active] 595496002174 putative metal binding site [ion binding]; other site 595496002175 putative phosphate binding site [ion binding]; other site 595496002176 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 595496002177 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 595496002178 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 595496002179 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 595496002180 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 595496002181 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 595496002182 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 595496002183 Walker A/P-loop; other site 595496002184 ATP binding site [chemical binding]; other site 595496002185 Q-loop/lid; other site 595496002186 ABC transporter signature motif; other site 595496002187 Walker B; other site 595496002188 D-loop; other site 595496002189 H-loop/switch region; other site 595496002190 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 595496002191 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 595496002192 Walker A/P-loop; other site 595496002193 ATP binding site [chemical binding]; other site 595496002194 Q-loop/lid; other site 595496002195 ABC transporter signature motif; other site 595496002196 Walker B; other site 595496002197 D-loop; other site 595496002198 H-loop/switch region; other site 595496002199 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 595496002200 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 595496002201 HlyD family secretion protein; Region: HlyD_3; pfam13437 595496002202 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 595496002203 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 595496002204 helicase 45; Provisional; Region: PTZ00424 595496002205 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 595496002206 ATP binding site [chemical binding]; other site 595496002207 Mg++ binding site [ion binding]; other site 595496002208 motif III; other site 595496002209 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 595496002210 nucleotide binding region [chemical binding]; other site 595496002211 ATP-binding site [chemical binding]; other site 595496002212 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3236 595496002213 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 595496002214 DEAD_2; Region: DEAD_2; pfam06733 595496002215 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 595496002216 glycosyl transferase family protein; Provisional; Region: PRK08136 595496002217 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 595496002218 putative dehydrogenase; Provisional; Region: PRK10098 595496002219 hypothetical protein; Provisional; Region: PRK10259 595496002220 hypothetical protein; Provisional; Region: PRK11019 595496002221 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 595496002222 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 595496002223 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 595496002224 N-terminal plug; other site 595496002225 ligand-binding site [chemical binding]; other site 595496002226 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 595496002227 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 595496002228 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 595496002229 putative mechanosensitive channel protein; Provisional; Region: PRK11465 595496002230 Mechanosensitive ion channel; Region: MS_channel; pfam00924 595496002231 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 595496002232 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 595496002233 Walker A/P-loop; other site 595496002234 ATP binding site [chemical binding]; other site 595496002235 Q-loop/lid; other site 595496002236 ABC transporter signature motif; other site 595496002237 Walker B; other site 595496002238 D-loop; other site 595496002239 H-loop/switch region; other site 595496002240 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 595496002241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496002242 dimer interface [polypeptide binding]; other site 595496002243 conserved gate region; other site 595496002244 putative PBP binding loops; other site 595496002245 ABC-ATPase subunit interface; other site 595496002246 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 595496002247 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 595496002248 substrate binding pocket [chemical binding]; other site 595496002249 membrane-bound complex binding site; other site 595496002250 hinge residues; other site 595496002251 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 595496002252 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 595496002253 dimerization interface [polypeptide binding]; other site 595496002254 DPS ferroxidase diiron center [ion binding]; other site 595496002255 ion pore; other site 595496002256 threonine and homoserine efflux system; Provisional; Region: PRK10532 595496002257 EamA-like transporter family; Region: EamA; pfam00892 595496002258 outer membrane protein X; Provisional; Region: ompX; PRK09408 595496002259 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 595496002260 Sulfatase; Region: Sulfatase; pfam00884 595496002261 manganese transport regulator MntR; Provisional; Region: PRK11050 595496002262 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 595496002263 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 595496002264 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 595496002265 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 595496002266 transmembrane helices; other site 595496002267 L,D-transpeptidase; Provisional; Region: PRK10260 595496002268 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 595496002269 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 595496002270 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 595496002271 Walker A/P-loop; other site 595496002272 ATP binding site [chemical binding]; other site 595496002273 Q-loop/lid; other site 595496002274 ABC transporter signature motif; other site 595496002275 Walker B; other site 595496002276 D-loop; other site 595496002277 H-loop/switch region; other site 595496002278 ABC transporter; Region: ABC_tran_2; pfam12848 595496002279 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 595496002280 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 595496002281 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 595496002282 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 595496002283 active site 595496002284 motif I; other site 595496002285 motif II; other site 595496002286 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 595496002287 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 595496002288 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 595496002289 dimer interface [polypeptide binding]; other site 595496002290 active site 595496002291 glycine loop; other site 595496002292 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 595496002293 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 595496002294 active site 595496002295 intersubunit interactions; other site 595496002296 catalytic residue [active] 595496002297 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 595496002298 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 595496002299 ATP binding site [chemical binding]; other site 595496002300 substrate interface [chemical binding]; other site 595496002301 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 595496002302 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 595496002303 dimer interface [polypeptide binding]; other site 595496002304 putative functional site; other site 595496002305 putative MPT binding site; other site 595496002306 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 595496002307 catalytic nucleophile [active] 595496002308 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 595496002309 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 595496002310 Walker A/P-loop; other site 595496002311 ATP binding site [chemical binding]; other site 595496002312 Q-loop/lid; other site 595496002313 ABC transporter signature motif; other site 595496002314 Walker B; other site 595496002315 D-loop; other site 595496002316 H-loop/switch region; other site 595496002317 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 595496002318 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 595496002319 Walker A/P-loop; other site 595496002320 ATP binding site [chemical binding]; other site 595496002321 Q-loop/lid; other site 595496002322 ABC transporter signature motif; other site 595496002323 Walker B; other site 595496002324 D-loop; other site 595496002325 H-loop/switch region; other site 595496002326 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 595496002327 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 595496002328 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 595496002329 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 595496002330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496002331 dimer interface [polypeptide binding]; other site 595496002332 conserved gate region; other site 595496002333 putative PBP binding loops; other site 595496002334 ABC-ATPase subunit interface; other site 595496002335 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 595496002336 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 595496002337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496002338 dimer interface [polypeptide binding]; other site 595496002339 conserved gate region; other site 595496002340 putative PBP binding loops; other site 595496002341 ABC-ATPase subunit interface; other site 595496002342 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 595496002343 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 595496002344 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 595496002345 metal binding site [ion binding]; metal-binding site 595496002346 active site 595496002347 I-site; other site 595496002348 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 595496002349 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 595496002350 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 595496002351 FeS/SAM binding site; other site 595496002352 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 595496002353 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 595496002354 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 595496002355 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 595496002356 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 595496002357 putative C-terminal domain interface [polypeptide binding]; other site 595496002358 putative GSH binding site (G-site) [chemical binding]; other site 595496002359 putative dimer interface [polypeptide binding]; other site 595496002360 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 595496002361 N-terminal domain interface [polypeptide binding]; other site 595496002362 dimer interface [polypeptide binding]; other site 595496002363 substrate binding pocket (H-site) [chemical binding]; other site 595496002364 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 595496002365 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 595496002366 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 595496002367 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 595496002368 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 595496002369 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 595496002370 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 595496002371 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 595496002372 active site 595496002373 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 595496002374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496002375 putative substrate translocation pore; other site 595496002376 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 595496002377 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 595496002378 active site 595496002379 motif I; other site 595496002380 motif II; other site 595496002381 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 595496002382 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 595496002383 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496002384 putative substrate translocation pore; other site 595496002385 Major Facilitator Superfamily; Region: MFS_1; pfam07690 595496002386 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 595496002387 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 595496002388 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 595496002389 putative transporter; Provisional; Region: PRK04972 595496002390 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 595496002391 TrkA-C domain; Region: TrkA_C; pfam02080 595496002392 TrkA-C domain; Region: TrkA_C; pfam02080 595496002393 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 595496002394 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 595496002395 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 595496002396 GSH binding site [chemical binding]; other site 595496002397 catalytic residues [active] 595496002398 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 595496002399 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 595496002400 dimer interface [polypeptide binding]; other site 595496002401 FMN binding site [chemical binding]; other site 595496002402 NADPH bind site [chemical binding]; other site 595496002403 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 595496002404 RimK-like ATP-grasp domain; Region: RimK; pfam08443 595496002405 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 595496002406 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 595496002407 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 595496002408 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 595496002409 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 595496002410 Walker A/P-loop; other site 595496002411 ATP binding site [chemical binding]; other site 595496002412 Q-loop/lid; other site 595496002413 ABC transporter signature motif; other site 595496002414 Walker B; other site 595496002415 D-loop; other site 595496002416 H-loop/switch region; other site 595496002417 TOBE domain; Region: TOBE_2; pfam08402 595496002418 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 595496002419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496002420 dimer interface [polypeptide binding]; other site 595496002421 conserved gate region; other site 595496002422 putative PBP binding loops; other site 595496002423 ABC-ATPase subunit interface; other site 595496002424 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 595496002425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496002426 dimer interface [polypeptide binding]; other site 595496002427 conserved gate region; other site 595496002428 putative PBP binding loops; other site 595496002429 ABC-ATPase subunit interface; other site 595496002430 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 595496002431 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 595496002432 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 595496002433 S-adenosylmethionine binding site [chemical binding]; other site 595496002434 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 595496002435 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 595496002436 substrate binding pocket [chemical binding]; other site 595496002437 membrane-bound complex binding site; other site 595496002438 hinge residues; other site 595496002439 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496002440 dimer interface [polypeptide binding]; other site 595496002441 conserved gate region; other site 595496002442 putative PBP binding loops; other site 595496002443 ABC-ATPase subunit interface; other site 595496002444 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 595496002445 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496002446 dimer interface [polypeptide binding]; other site 595496002447 conserved gate region; other site 595496002448 putative PBP binding loops; other site 595496002449 ABC-ATPase subunit interface; other site 595496002450 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 595496002451 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 595496002452 substrate binding pocket [chemical binding]; other site 595496002453 membrane-bound complex binding site; other site 595496002454 hinge residues; other site 595496002455 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 595496002456 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 595496002457 Walker A/P-loop; other site 595496002458 ATP binding site [chemical binding]; other site 595496002459 Q-loop/lid; other site 595496002460 ABC transporter signature motif; other site 595496002461 Walker B; other site 595496002462 D-loop; other site 595496002463 H-loop/switch region; other site 595496002464 putative lipoprotein; Provisional; Region: PRK10533 595496002465 hypothetical protein; Provisional; Region: PRK02877 595496002466 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 595496002467 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 595496002468 amidase catalytic site [active] 595496002469 Zn binding residues [ion binding]; other site 595496002470 substrate binding site [chemical binding]; other site 595496002471 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 595496002472 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 595496002473 NAD(P) binding site [chemical binding]; other site 595496002474 active site 595496002475 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 595496002476 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 595496002477 putative NAD(P) binding site [chemical binding]; other site 595496002478 putative active site [active] 595496002479 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 595496002480 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 595496002481 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 595496002482 tetramer interface [polypeptide binding]; other site 595496002483 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496002484 catalytic residue [active] 595496002485 pyruvate dehydrogenase; Provisional; Region: PRK09124 595496002486 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 595496002487 PYR/PP interface [polypeptide binding]; other site 595496002488 dimer interface [polypeptide binding]; other site 595496002489 tetramer interface [polypeptide binding]; other site 595496002490 TPP binding site [chemical binding]; other site 595496002491 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 595496002492 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 595496002493 TPP-binding site [chemical binding]; other site 595496002494 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 595496002495 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 595496002496 FAD binding pocket [chemical binding]; other site 595496002497 FAD binding motif [chemical binding]; other site 595496002498 phosphate binding motif [ion binding]; other site 595496002499 beta-alpha-beta structure motif; other site 595496002500 NAD binding pocket [chemical binding]; other site 595496002501 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 595496002502 catalytic loop [active] 595496002503 iron binding site [ion binding]; other site 595496002504 hybrid cluster protein; Provisional; Region: PRK05290 595496002505 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 595496002506 ACS interaction site; other site 595496002507 CODH interaction site; other site 595496002508 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 595496002509 hybrid metal cluster; other site 595496002510 Predicted membrane protein [Function unknown]; Region: COG2431 595496002511 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 595496002512 amphipathic channel; other site 595496002513 Asn-Pro-Ala signature motifs; other site 595496002514 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 595496002515 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 595496002516 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 595496002517 putative active site [active] 595496002518 putative metal-binding site [ion binding]; other site 595496002519 Protein of unknown function (DUF535); Region: DUF535; pfam04393 595496002520 macrolide transporter subunit MacA; Provisional; Region: PRK11578 595496002521 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 595496002522 HlyD family secretion protein; Region: HlyD_3; pfam13437 595496002523 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 595496002524 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 595496002525 Walker A/P-loop; other site 595496002526 ATP binding site [chemical binding]; other site 595496002527 Q-loop/lid; other site 595496002528 ABC transporter signature motif; other site 595496002529 Walker B; other site 595496002530 D-loop; other site 595496002531 H-loop/switch region; other site 595496002532 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 595496002533 FtsX-like permease family; Region: FtsX; pfam02687 595496002534 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 595496002535 DNA-binding site [nucleotide binding]; DNA binding site 595496002536 RNA-binding motif; other site 595496002537 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 595496002538 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 595496002539 Clp amino terminal domain; Region: Clp_N; pfam02861 595496002540 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 595496002541 Walker A motif; other site 595496002542 ATP binding site [chemical binding]; other site 595496002543 Walker B motif; other site 595496002544 arginine finger; other site 595496002545 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 595496002546 Walker A motif; other site 595496002547 ATP binding site [chemical binding]; other site 595496002548 Walker B motif; other site 595496002549 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 595496002550 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 595496002551 rRNA binding site [nucleotide binding]; other site 595496002552 predicted 30S ribosome binding site; other site 595496002553 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 595496002554 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 595496002555 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 595496002556 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 595496002557 Walker A/P-loop; other site 595496002558 ATP binding site [chemical binding]; other site 595496002559 Q-loop/lid; other site 595496002560 ABC transporter signature motif; other site 595496002561 Walker B; other site 595496002562 D-loop; other site 595496002563 H-loop/switch region; other site 595496002564 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 595496002565 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 595496002566 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 595496002567 Walker A/P-loop; other site 595496002568 ATP binding site [chemical binding]; other site 595496002569 Q-loop/lid; other site 595496002570 ABC transporter signature motif; other site 595496002571 Walker B; other site 595496002572 D-loop; other site 595496002573 H-loop/switch region; other site 595496002574 thioredoxin reductase; Provisional; Region: PRK10262 595496002575 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 595496002576 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 595496002577 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 595496002578 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 595496002579 putative DNA binding site [nucleotide binding]; other site 595496002580 putative Zn2+ binding site [ion binding]; other site 595496002581 AsnC family; Region: AsnC_trans_reg; pfam01037 595496002582 DNA translocase FtsK; Provisional; Region: PRK10263 595496002583 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 595496002584 DNA translocase FtsK; Provisional; Region: PRK10263 595496002585 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 595496002586 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 595496002587 periplasmic chaperone LolA; Region: lolA; TIGR00547 595496002588 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 595496002589 recombination factor protein RarA; Reviewed; Region: PRK13342 595496002590 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 595496002591 Walker A motif; other site 595496002592 ATP binding site [chemical binding]; other site 595496002593 Walker B motif; other site 595496002594 arginine finger; other site 595496002595 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 595496002596 seryl-tRNA synthetase; Provisional; Region: PRK05431 595496002597 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 595496002598 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 595496002599 dimer interface [polypeptide binding]; other site 595496002600 active site 595496002601 motif 1; other site 595496002602 motif 2; other site 595496002603 motif 3; other site 595496002604 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 595496002605 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 595496002606 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 595496002607 putative [Fe4-S4] binding site [ion binding]; other site 595496002608 putative molybdopterin cofactor binding site [chemical binding]; other site 595496002609 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 595496002610 putative molybdopterin cofactor binding site; other site 595496002611 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 595496002612 4Fe-4S binding domain; Region: Fer4; pfam00037 595496002613 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 595496002614 Isochorismatase family; Region: Isochorismatase; pfam00857 595496002615 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 595496002616 catalytic triad [active] 595496002617 dimer interface [polypeptide binding]; other site 595496002618 conserved cis-peptide bond; other site 595496002619 putative MFS family transporter protein; Provisional; Region: PRK03633 595496002620 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496002621 putative substrate translocation pore; other site 595496002622 Amino acid permease; Region: AA_permease_2; pfam13520 595496002623 Transcriptional regulator [Transcription]; Region: LysR; COG0583 595496002624 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496002625 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 595496002626 putative effector binding pocket; other site 595496002627 putative dimerization interface [polypeptide binding]; other site 595496002628 hypothetical protein; Provisional; Region: PRK09739 595496002629 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 595496002630 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 595496002631 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 595496002632 FeS/SAM binding site; other site 595496002633 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 595496002634 Pyruvate formate lyase 1; Region: PFL1; cd01678 595496002635 coenzyme A binding site [chemical binding]; other site 595496002636 active site 595496002637 catalytic residues [active] 595496002638 glycine loop; other site 595496002639 formate transporter; Provisional; Region: PRK10805 595496002640 uncharacterized domain; Region: TIGR00702 595496002641 YcaO-like family; Region: YcaO; pfam02624 595496002642 Predicted membrane protein [Function unknown]; Region: COG2323 595496002643 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 595496002644 homodimer interface [polypeptide binding]; other site 595496002645 substrate-cofactor binding pocket; other site 595496002646 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496002647 catalytic residue [active] 595496002648 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 595496002649 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 595496002650 hinge; other site 595496002651 active site 595496002652 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 595496002653 cytidylate kinase; Provisional; Region: cmk; PRK00023 595496002654 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 595496002655 CMP-binding site; other site 595496002656 The sites determining sugar specificity; other site 595496002657 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 595496002658 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 595496002659 RNA binding site [nucleotide binding]; other site 595496002660 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 595496002661 RNA binding site [nucleotide binding]; other site 595496002662 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 595496002663 RNA binding site [nucleotide binding]; other site 595496002664 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 595496002665 RNA binding site [nucleotide binding]; other site 595496002666 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 595496002667 RNA binding site [nucleotide binding]; other site 595496002668 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 595496002669 IHF dimer interface [polypeptide binding]; other site 595496002670 IHF - DNA interface [nucleotide binding]; other site 595496002671 ComEC family competence protein; Provisional; Region: PRK11539 595496002672 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 595496002673 ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360 595496002674 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 595496002675 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 595496002676 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 595496002677 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 595496002678 Walker A/P-loop; other site 595496002679 ATP binding site [chemical binding]; other site 595496002680 Q-loop/lid; other site 595496002681 ABC transporter signature motif; other site 595496002682 Walker B; other site 595496002683 D-loop; other site 595496002684 H-loop/switch region; other site 595496002685 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 595496002686 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 595496002687 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 595496002688 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 595496002689 hypothetical protein; Provisional; Region: PRK11827 595496002690 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 595496002691 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 595496002692 Ligand binding site; other site 595496002693 oligomer interface; other site 595496002694 hypothetical protein; Provisional; Region: PRK10593 595496002695 Uncharacterized conserved protein [Function unknown]; Region: COG1434 595496002696 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 595496002697 putative active site [active] 595496002698 Methyltransferase domain; Region: Methyltransf_31; pfam13847 595496002699 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 595496002700 S-adenosylmethionine binding site [chemical binding]; other site 595496002701 condesin subunit F; Provisional; Region: PRK05260 595496002702 condesin subunit E; Provisional; Region: PRK05256 595496002703 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 595496002704 MukB N-terminal; Region: MukB; pfam04310 595496002705 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 595496002706 murein L,D-transpeptidase; Provisional; Region: PRK10594 595496002707 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 595496002708 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 595496002709 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 595496002710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 595496002711 Peptidase M15; Region: Peptidase_M15_3; cl01194 595496002712 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 595496002713 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 595496002714 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 595496002715 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496002716 homodimer interface [polypeptide binding]; other site 595496002717 catalytic residue [active] 595496002718 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 595496002719 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 595496002720 trimer interface [polypeptide binding]; other site 595496002721 eyelet of channel; other site 595496002722 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 595496002723 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 595496002724 putative dimer interface [polypeptide binding]; other site 595496002725 putative anticodon binding site; other site 595496002726 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 595496002727 homodimer interface [polypeptide binding]; other site 595496002728 motif 1; other site 595496002729 motif 2; other site 595496002730 active site 595496002731 motif 3; other site 595496002732 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 595496002733 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 595496002734 active site 595496002735 aminopeptidase N; Provisional; Region: pepN; PRK14015 595496002736 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 595496002737 active site 595496002738 Zn binding site [ion binding]; other site 595496002739 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 595496002740 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 595496002741 Walker A/P-loop; other site 595496002742 ATP binding site [chemical binding]; other site 595496002743 Q-loop/lid; other site 595496002744 ABC transporter signature motif; other site 595496002745 Walker B; other site 595496002746 D-loop; other site 595496002747 H-loop/switch region; other site 595496002748 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 595496002749 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496002750 dimer interface [polypeptide binding]; other site 595496002751 conserved gate region; other site 595496002752 putative PBP binding loops; other site 595496002753 ABC-ATPase subunit interface; other site 595496002754 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 595496002755 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 595496002756 active site 595496002757 dimer interface [polypeptide binding]; other site 595496002758 non-prolyl cis peptide bond; other site 595496002759 insertion regions; other site 595496002760 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 595496002761 substrate binding pocket [chemical binding]; other site 595496002762 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 595496002763 membrane-bound complex binding site; other site 595496002764 hinge residues; other site 595496002765 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 595496002766 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 595496002767 Fimbrial protein; Region: Fimbrial; cl01416 595496002768 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 595496002769 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 595496002770 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 595496002771 outer membrane usher protein; Provisional; Region: PRK15193 595496002772 PapC N-terminal domain; Region: PapC_N; pfam13954 595496002773 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 595496002774 PapC C-terminal domain; Region: PapC_C; pfam13953 595496002775 Fimbrial protein; Region: Fimbrial; cl01416 595496002776 Fimbrial protein; Region: Fimbrial; cl01416 595496002777 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 595496002778 putativi pili assembly chaperone; Provisional; Region: PRK11385 595496002779 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 595496002780 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 595496002781 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 595496002782 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 595496002783 quinone interaction residues [chemical binding]; other site 595496002784 active site 595496002785 catalytic residues [active] 595496002786 FMN binding site [chemical binding]; other site 595496002787 substrate binding site [chemical binding]; other site 595496002788 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 595496002789 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 595496002790 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 595496002791 MOSC domain; Region: MOSC; pfam03473 595496002792 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 595496002793 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 595496002794 catalytic loop [active] 595496002795 iron binding site [ion binding]; other site 595496002796 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 595496002797 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 595496002798 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 595496002799 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 595496002800 S-adenosylmethionine binding site [chemical binding]; other site 595496002801 ABC transporter ATPase component; Reviewed; Region: PRK11147 595496002802 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 595496002803 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 595496002804 Walker A/P-loop; other site 595496002805 Walker A/P-loop; other site 595496002806 ATP binding site [chemical binding]; other site 595496002807 ATP binding site [chemical binding]; other site 595496002808 Q-loop/lid; other site 595496002809 Q-loop/lid; other site 595496002810 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 595496002811 ABC transporter signature motif; other site 595496002812 Walker B; other site 595496002813 D-loop; other site 595496002814 ABC transporter; Region: ABC_tran_2; pfam12848 595496002815 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 595496002816 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 595496002817 Paraquat-inducible protein A; Region: PqiA; pfam04403 595496002818 Paraquat-inducible protein A; Region: PqiA; pfam04403 595496002819 paraquat-inducible protein B; Provisional; Region: PRK10807 595496002820 mce related protein; Region: MCE; pfam02470 595496002821 mce related protein; Region: MCE; pfam02470 595496002822 mce related protein; Region: MCE; pfam02470 595496002823 DASH complex subunit Duo1; Region: DASH_Duo1; pfam08651 595496002824 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 595496002825 Protein of unknown function (DUF330); Region: DUF330; pfam03886 595496002826 ribosome modulation factor; Provisional; Region: PRK14563 595496002827 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 595496002828 active site 1 [active] 595496002829 dimer interface [polypeptide binding]; other site 595496002830 active site 2 [active] 595496002831 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 595496002832 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 595496002833 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 595496002834 outer membrane protein A; Reviewed; Region: PRK10808 595496002835 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 595496002836 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 595496002837 ligand binding site [chemical binding]; other site 595496002838 cell division inhibitor SulA; Region: sula; TIGR00623 595496002839 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 595496002840 TfoX C-terminal domain; Region: TfoX_C; pfam04994 595496002841 TIGR01666 family membrane protein; Region: YCCS 595496002842 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 595496002843 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 595496002844 Predicted membrane protein [Function unknown]; Region: COG3304 595496002845 Domain of unknown function (DUF307); Region: DUF307; pfam03733 595496002846 Domain of unknown function (DUF307); Region: DUF307; pfam03733 595496002847 DNA helicase IV; Provisional; Region: helD; PRK11054 595496002848 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 595496002849 Part of AAA domain; Region: AAA_19; pfam13245 595496002850 Family description; Region: UvrD_C_2; pfam13538 595496002851 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 595496002852 active site 595496002853 dimer interfaces [polypeptide binding]; other site 595496002854 catalytic residues [active] 595496002855 hypothetical protein; Provisional; Region: PRK03641 595496002856 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 595496002857 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 595496002858 heat shock protein HspQ; Provisional; Region: PRK14129 595496002859 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 595496002860 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 595496002861 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 595496002862 putative RNA binding site [nucleotide binding]; other site 595496002863 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 595496002864 S-adenosylmethionine binding site [chemical binding]; other site 595496002865 Acylphosphatase; Region: Acylphosphatase; cl00551 595496002866 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 595496002867 sulfur transfer protein TusE; Provisional; Region: PRK11508 595496002868 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 595496002869 YccA-like proteins; Region: YccA_like; cd10433 595496002870 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 595496002871 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 595496002872 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 595496002873 hydrogenase 1 large subunit; Provisional; Region: PRK10170 595496002874 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 595496002875 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 595496002876 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 595496002877 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 595496002878 putative substrate-binding site; other site 595496002879 nickel binding site [ion binding]; other site 595496002880 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 595496002881 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 595496002882 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 595496002883 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 595496002884 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 595496002885 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 595496002886 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 595496002887 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 595496002888 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 595496002889 catalytic core [active] 595496002890 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 595496002891 cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841 595496002892 Chain length determinant protein; Region: Wzz; pfam02706 595496002893 Chain length determinant protein; Region: Wzz; cl15801 595496002894 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 595496002895 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 595496002896 Nucleotide binding site [chemical binding]; other site 595496002897 Low molecular weight phosphatase family; Region: LMWPc; cd00115 595496002898 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 595496002899 active site 595496002900 polysaccharide export protein Wza; Provisional; Region: PRK15078 595496002901 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 595496002902 SLBB domain; Region: SLBB; pfam10531 595496002903 SLBB domain; Region: SLBB; pfam10531 595496002904 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 595496002905 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 595496002906 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 595496002907 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 595496002908 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 595496002909 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 595496002910 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 595496002911 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 595496002912 DNA-binding site [nucleotide binding]; DNA binding site 595496002913 RNA-binding motif; other site 595496002914 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 595496002915 DNA-binding site [nucleotide binding]; DNA binding site 595496002916 RNA-binding motif; other site 595496002917 cold shock gene; Provisional; Region: PRK09891 595496002918 GnsA/GnsB family; Region: GnsAB; pfam08178 595496002919 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 595496002920 4Fe-4S binding domain; Region: Fer4_5; pfam12801 595496002921 4Fe-4S binding domain; Region: Fer4_5; pfam12801 595496002922 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 595496002923 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 595496002924 HAMP domain; Region: HAMP; pfam00672 595496002925 dimerization interface [polypeptide binding]; other site 595496002926 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 595496002927 dimer interface [polypeptide binding]; other site 595496002928 phosphorylation site [posttranslational modification] 595496002929 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 595496002930 ATP binding site [chemical binding]; other site 595496002931 Mg2+ binding site [ion binding]; other site 595496002932 G-X-G motif; other site 595496002933 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 595496002934 active site 595496002935 phosphorylation site [posttranslational modification] 595496002936 intermolecular recognition site; other site 595496002937 dimerization interface [polypeptide binding]; other site 595496002938 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 595496002939 putative binding surface; other site 595496002940 active site 595496002941 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 595496002942 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 595496002943 putative ligand binding site [chemical binding]; other site 595496002944 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 595496002945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 595496002946 active site 595496002947 phosphorylation site [posttranslational modification] 595496002948 intermolecular recognition site; other site 595496002949 dimerization interface [polypeptide binding]; other site 595496002950 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 595496002951 DNA binding site [nucleotide binding] 595496002952 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 595496002953 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 595496002954 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 595496002955 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 595496002956 molybdopterin cofactor binding site [chemical binding]; other site 595496002957 substrate binding site [chemical binding]; other site 595496002958 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 595496002959 molybdopterin cofactor binding site; other site 595496002960 chaperone protein TorD; Validated; Region: torD; PRK04976 595496002961 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 595496002962 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 595496002963 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 595496002964 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 595496002965 HSP70 interaction site [polypeptide binding]; other site 595496002966 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 595496002967 substrate binding site [polypeptide binding]; other site 595496002968 dimer interface [polypeptide binding]; other site 595496002969 hypothetical protein; Provisional; Region: PRK09784 595496002970 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 595496002971 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 595496002972 catalytic core [active] 595496002973 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 595496002974 hypothetical protein; Provisional; Region: PRK10174 595496002975 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 595496002976 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 595496002977 General stress protein [General function prediction only]; Region: GsiB; COG3729 595496002978 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 595496002979 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 595496002980 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 595496002981 putative FMN binding site [chemical binding]; other site 595496002982 pyrimidine utilization protein D; Region: RutD; TIGR03611 595496002983 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 595496002984 homotrimer interaction site [polypeptide binding]; other site 595496002985 putative active site [active] 595496002986 Isochorismatase family; Region: Isochorismatase; pfam00857 595496002987 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 595496002988 catalytic triad [active] 595496002989 conserved cis-peptide bond; other site 595496002990 pyrimidine utilization protein A; Region: RutA; TIGR03612 595496002991 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 595496002992 active site 595496002993 dimer interface [polypeptide binding]; other site 595496002994 non-prolyl cis peptide bond; other site 595496002995 insertion regions; other site 595496002996 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 595496002997 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 595496002998 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 595496002999 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 595496003000 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 595496003001 Predicted transcriptional regulator [Transcription]; Region: COG3905 595496003002 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 595496003003 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 595496003004 Glutamate binding site [chemical binding]; other site 595496003005 NAD binding site [chemical binding]; other site 595496003006 catalytic residues [active] 595496003007 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 595496003008 Na binding site [ion binding]; other site 595496003009 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 595496003010 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 595496003011 Imelysin; Region: Peptidase_M75; pfam09375 595496003012 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 595496003013 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 595496003014 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 595496003015 hypothetical protein; Provisional; Region: PRK10536 595496003016 putative PGA biosynthesis protein; Provisional; Region: pgaD; PRK14585 595496003017 N-glycosyltransferase; Provisional; Region: PRK11204 595496003018 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 595496003019 DXD motif; other site 595496003020 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 595496003021 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 595496003022 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 595496003023 putative active site [active] 595496003024 putative metal binding site [ion binding]; other site 595496003025 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 595496003026 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 595496003027 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 595496003028 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 595496003029 metal binding site [ion binding]; metal-binding site 595496003030 active site 595496003031 I-site; other site 595496003032 putative transposase OrfB; Reviewed; Region: PHA02517 595496003033 HTH-like domain; Region: HTH_21; pfam13276 595496003034 Integrase core domain; Region: rve; pfam00665 595496003035 Integrase core domain; Region: rve_2; pfam13333 595496003036 Transposase; Region: HTH_Tnp_1; cl17663 595496003037 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 595496003038 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 595496003039 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 595496003040 putative ligand binding site [chemical binding]; other site 595496003041 NAD binding site [chemical binding]; other site 595496003042 dimerization interface [polypeptide binding]; other site 595496003043 catalytic site [active] 595496003044 putative hydrolase; Validated; Region: PRK09248 595496003045 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 595496003046 active site 595496003047 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 595496003048 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 595496003049 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 595496003050 curli assembly protein CsgF; Provisional; Region: PRK10050 595496003051 curli assembly protein CsgE; Provisional; Region: PRK10386 595496003052 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 595496003053 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 595496003054 DNA binding residues [nucleotide binding] 595496003055 dimerization interface [polypeptide binding]; other site 595496003056 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 595496003057 Curlin associated repeat; Region: Curlin_rpt; pfam07012 595496003058 Curlin associated repeat; Region: Curlin_rpt; pfam07012 595496003059 major curlin subunit; Provisional; Region: csgA; PRK10051 595496003060 Curlin associated repeat; Region: Curlin_rpt; pfam07012 595496003061 Curlin associated repeat; Region: Curlin_rpt; pfam07012 595496003062 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 595496003063 Fimbrial protein; Region: Fimbrial; cl01416 595496003064 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 595496003065 putative ADP-ribose binding site [chemical binding]; other site 595496003066 putative active site [active] 595496003067 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 595496003068 PLD-like domain; Region: PLDc_2; pfam13091 595496003069 putative active site [active] 595496003070 catalytic site [active] 595496003071 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 595496003072 PLD-like domain; Region: PLDc_2; pfam13091 595496003073 putative active site [active] 595496003074 catalytic site [active] 595496003075 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 595496003076 Acyltransferase family; Region: Acyl_transf_3; pfam01757 595496003077 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 595496003078 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 595496003079 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 595496003080 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 595496003081 Ligand binding site; other site 595496003082 DXD motif; other site 595496003083 lipoprotein; Provisional; Region: PRK10175 595496003084 secY/secA suppressor protein; Provisional; Region: PRK11467 595496003085 drug efflux system protein MdtG; Provisional; Region: PRK09874 595496003086 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496003087 putative substrate translocation pore; other site 595496003088 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 595496003089 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 595496003090 putative acyl-acceptor binding pocket; other site 595496003091 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 595496003092 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 595496003093 active site residue [active] 595496003094 hypothetical protein; Provisional; Region: PRK03757 595496003095 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 595496003096 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 595496003097 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 595496003098 hydroxyglutarate oxidase; Provisional; Region: PRK11728 595496003099 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 595496003100 DNA damage-inducible protein I; Provisional; Region: PRK10597 595496003101 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 595496003102 active site 595496003103 substrate binding pocket [chemical binding]; other site 595496003104 dimer interface [polypeptide binding]; other site 595496003105 lipoprotein; Provisional; Region: PRK10598 595496003106 glutaredoxin 2; Provisional; Region: PRK10387 595496003107 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 595496003108 C-terminal domain interface [polypeptide binding]; other site 595496003109 GSH binding site (G-site) [chemical binding]; other site 595496003110 catalytic residues [active] 595496003111 putative dimer interface [polypeptide binding]; other site 595496003112 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 595496003113 N-terminal domain interface [polypeptide binding]; other site 595496003114 multidrug resistance protein MdtH; Provisional; Region: PRK11646 595496003115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496003116 putative substrate translocation pore; other site 595496003117 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 595496003118 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 595496003119 hypothetical protein; Provisional; Region: PRK11239 595496003120 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 595496003121 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 595496003122 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 595496003123 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 595496003124 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 595496003125 MviN-like protein; Region: MVIN; pfam03023 595496003126 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 595496003127 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 595496003128 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 595496003129 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 595496003130 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 595496003131 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 595496003132 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 595496003133 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 595496003134 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 595496003135 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 595496003136 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 595496003137 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 595496003138 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 595496003139 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 595496003140 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 595496003141 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 595496003142 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 595496003143 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 595496003144 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 595496003145 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 595496003146 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 595496003147 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 595496003148 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 595496003149 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 595496003150 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 595496003151 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 595496003152 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 595496003153 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 595496003154 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 595496003155 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 595496003156 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 595496003157 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 595496003158 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 595496003159 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 595496003160 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 595496003161 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 595496003162 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 595496003163 homodimer interface [polypeptide binding]; other site 595496003164 oligonucleotide binding site [chemical binding]; other site 595496003165 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 595496003166 Protein of unknown function (DUF2655); Region: DUF2655; pfam10848 595496003167 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 595496003168 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 595496003169 RNA binding surface [nucleotide binding]; other site 595496003170 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 595496003171 active site 595496003172 Maf-like protein; Region: Maf; pfam02545 595496003173 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 595496003174 active site 595496003175 dimer interface [polypeptide binding]; other site 595496003176 hypothetical protein; Provisional; Region: PRK11193 595496003177 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 595496003178 putative phosphate acyltransferase; Provisional; Region: PRK05331 595496003179 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 595496003180 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 595496003181 dimer interface [polypeptide binding]; other site 595496003182 active site 595496003183 CoA binding pocket [chemical binding]; other site 595496003184 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 595496003185 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 595496003186 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 595496003187 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 595496003188 NAD(P) binding site [chemical binding]; other site 595496003189 homotetramer interface [polypeptide binding]; other site 595496003190 homodimer interface [polypeptide binding]; other site 595496003191 active site 595496003192 acyl carrier protein; Provisional; Region: acpP; PRK00982 595496003193 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 595496003194 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 595496003195 dimer interface [polypeptide binding]; other site 595496003196 active site 595496003197 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 595496003198 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 595496003199 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496003200 catalytic residue [active] 595496003201 conserved hypothetical protein, YceG family; Region: TIGR00247 595496003202 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 595496003203 dimerization interface [polypeptide binding]; other site 595496003204 thymidylate kinase; Validated; Region: tmk; PRK00698 595496003205 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 595496003206 TMP-binding site; other site 595496003207 ATP-binding site [chemical binding]; other site 595496003208 DNA polymerase III subunit delta'; Validated; Region: PRK07993 595496003209 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 595496003210 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 595496003211 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 595496003212 active site 595496003213 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 595496003214 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 595496003215 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 595496003216 active site turn [active] 595496003217 phosphorylation site [posttranslational modification] 595496003218 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 595496003219 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 595496003220 N-terminal plug; other site 595496003221 ligand-binding site [chemical binding]; other site 595496003222 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 595496003223 nucleotide binding site/active site [active] 595496003224 HIT family signature motif; other site 595496003225 catalytic residue [active] 595496003226 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 595496003227 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 595496003228 putative dimer interface [polypeptide binding]; other site 595496003229 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 595496003230 thiamine kinase; Region: ycfN_thiK; TIGR02721 595496003231 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 595496003232 active site 595496003233 substrate binding site [chemical binding]; other site 595496003234 ATP binding site [chemical binding]; other site 595496003235 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 595496003236 beta-hexosaminidase; Provisional; Region: PRK05337 595496003237 hypothetical protein; Provisional; Region: PRK04940 595496003238 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 595496003239 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 595496003240 hypothetical protein; Provisional; Region: PRK11280 595496003241 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 595496003242 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 595496003243 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 595496003244 L,D-transpeptidase; Provisional; Region: PRK10260 595496003245 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 595496003246 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 595496003247 transcription-repair coupling factor; Provisional; Region: PRK10689 595496003248 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 595496003249 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 595496003250 ATP binding site [chemical binding]; other site 595496003251 putative Mg++ binding site [ion binding]; other site 595496003252 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 595496003253 nucleotide binding region [chemical binding]; other site 595496003254 ATP-binding site [chemical binding]; other site 595496003255 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 595496003256 Predicted membrane protein [Function unknown]; Region: COG4763 595496003257 Acyltransferase family; Region: Acyl_transf_3; pfam01757 595496003258 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 595496003259 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 595496003260 FtsX-like permease family; Region: FtsX; pfam02687 595496003261 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 595496003262 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 595496003263 Walker A/P-loop; other site 595496003264 ATP binding site [chemical binding]; other site 595496003265 Q-loop/lid; other site 595496003266 ABC transporter signature motif; other site 595496003267 Walker B; other site 595496003268 D-loop; other site 595496003269 H-loop/switch region; other site 595496003270 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 595496003271 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 595496003272 FtsX-like permease family; Region: FtsX; pfam02687 595496003273 fructokinase; Reviewed; Region: PRK09557 595496003274 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 595496003275 nucleotide binding site [chemical binding]; other site 595496003276 NAD-dependent deacetylase; Provisional; Region: PRK00481 595496003277 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 595496003278 NAD+ binding site [chemical binding]; other site 595496003279 substrate binding site [chemical binding]; other site 595496003280 Zn binding site [ion binding]; other site 595496003281 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 595496003282 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 595496003283 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 595496003284 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 595496003285 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 595496003286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496003287 dimer interface [polypeptide binding]; other site 595496003288 conserved gate region; other site 595496003289 putative PBP binding loops; other site 595496003290 ABC-ATPase subunit interface; other site 595496003291 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 595496003292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496003293 dimer interface [polypeptide binding]; other site 595496003294 conserved gate region; other site 595496003295 putative PBP binding loops; other site 595496003296 ABC-ATPase subunit interface; other site 595496003297 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 595496003298 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 595496003299 Walker A/P-loop; other site 595496003300 ATP binding site [chemical binding]; other site 595496003301 Q-loop/lid; other site 595496003302 ABC transporter signature motif; other site 595496003303 Walker B; other site 595496003304 D-loop; other site 595496003305 H-loop/switch region; other site 595496003306 TOBE domain; Region: TOBE_2; pfam08402 595496003307 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 595496003308 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 595496003309 metal binding site [ion binding]; metal-binding site 595496003310 dimer interface [polypeptide binding]; other site 595496003311 Uncharacterized conserved protein [Function unknown]; Region: COG2850 595496003312 Cupin-like domain; Region: Cupin_8; pfam13621 595496003313 sensor protein PhoQ; Provisional; Region: PRK10815 595496003314 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 595496003315 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 595496003316 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 595496003317 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 595496003318 ATP binding site [chemical binding]; other site 595496003319 Mg2+ binding site [ion binding]; other site 595496003320 G-X-G motif; other site 595496003321 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 595496003322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 595496003323 active site 595496003324 phosphorylation site [posttranslational modification] 595496003325 intermolecular recognition site; other site 595496003326 dimerization interface [polypeptide binding]; other site 595496003327 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 595496003328 DNA binding site [nucleotide binding] 595496003329 adenylosuccinate lyase; Provisional; Region: PRK09285 595496003330 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 595496003331 tetramer interface [polypeptide binding]; other site 595496003332 active site 595496003333 putative lysogenization regulator; Reviewed; Region: PRK00218 595496003334 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 595496003335 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 595496003336 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 595496003337 nudix motif; other site 595496003338 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 595496003339 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 595496003340 probable active site [active] 595496003341 isocitrate dehydrogenase; Validated; Region: PRK07362 595496003342 isocitrate dehydrogenase; Reviewed; Region: PRK07006 595496003343 anti-adapter protein IraM; Provisional; Region: PRK09919 595496003344 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 595496003345 transcriptional regulator MirA; Provisional; Region: PRK15043 595496003346 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 595496003347 DNA binding residues [nucleotide binding] 595496003348 Sensors of blue-light using FAD; Region: BLUF; smart01034 595496003349 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 595496003350 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 595496003351 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 595496003352 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 595496003353 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 595496003354 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 595496003355 cell division inhibitor MinD; Provisional; Region: PRK10818 595496003356 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 595496003357 Switch I; other site 595496003358 Switch II; other site 595496003359 septum formation inhibitor; Reviewed; Region: minC; PRK03511 595496003360 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 595496003361 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 595496003362 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 595496003363 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 595496003364 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 595496003365 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 595496003366 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 595496003367 hypothetical protein; Provisional; Region: PRK10691 595496003368 hypothetical protein; Provisional; Region: PRK05170 595496003369 hemolysin E; Provisional; Region: hlyE; PRK11376 595496003370 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 595496003371 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 595496003372 Catalytic site [active] 595496003373 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 595496003374 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 595496003375 active site 595496003376 DNA binding site [nucleotide binding] 595496003377 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 595496003378 disulfide bond formation protein B; Provisional; Region: PRK01749 595496003379 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 595496003380 transmembrane helices; other site 595496003381 fatty acid metabolism regulator; Provisional; Region: PRK04984 595496003382 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 595496003383 DNA-binding site [nucleotide binding]; DNA binding site 595496003384 FadR C-terminal domain; Region: FadR_C; pfam07840 595496003385 SpoVR family protein; Provisional; Region: PRK11767 595496003386 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 595496003387 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 595496003388 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 595496003389 alanine racemase; Reviewed; Region: dadX; PRK03646 595496003390 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 595496003391 active site 595496003392 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 595496003393 substrate binding site [chemical binding]; other site 595496003394 catalytic residues [active] 595496003395 dimer interface [polypeptide binding]; other site 595496003396 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 595496003397 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 595496003398 TrkA-C domain; Region: TrkA_C; pfam02080 595496003399 Transporter associated domain; Region: CorC_HlyC; smart01091 595496003400 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 595496003401 dimer interface [polypeptide binding]; other site 595496003402 catalytic triad [active] 595496003403 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 595496003404 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 595496003405 N-acetyl-D-glucosamine binding site [chemical binding]; other site 595496003406 catalytic residue [active] 595496003407 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 595496003408 Flagellar regulator YcgR; Region: YcgR; pfam07317 595496003409 PilZ domain; Region: PilZ; pfam07238 595496003410 hypothetical protein; Provisional; Region: PRK10457 595496003411 trehalase; Provisional; Region: treA; PRK13271 595496003412 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 595496003413 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 595496003414 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 595496003415 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 595496003416 dimerization domain swap beta strand [polypeptide binding]; other site 595496003417 regulatory protein interface [polypeptide binding]; other site 595496003418 active site 595496003419 regulatory phosphorylation site [posttranslational modification]; other site 595496003420 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 595496003421 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 595496003422 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 595496003423 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 595496003424 Dak1 domain; Region: Dak1; pfam02733 595496003425 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 595496003426 PAS domain; Region: PAS; smart00091 595496003427 putative active site [active] 595496003428 heme pocket [chemical binding]; other site 595496003429 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 595496003430 Walker A motif; other site 595496003431 ATP binding site [chemical binding]; other site 595496003432 Walker B motif; other site 595496003433 arginine finger; other site 595496003434 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 595496003435 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 595496003436 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 595496003437 Autotransporter beta-domain; Region: Autotransporter; pfam03797 595496003438 GTP-binding protein YchF; Reviewed; Region: PRK09601 595496003439 YchF GTPase; Region: YchF; cd01900 595496003440 G1 box; other site 595496003441 GTP/Mg2+ binding site [chemical binding]; other site 595496003442 Switch I region; other site 595496003443 G2 box; other site 595496003444 Switch II region; other site 595496003445 G3 box; other site 595496003446 G4 box; other site 595496003447 G5 box; other site 595496003448 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 595496003449 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 595496003450 putative active site [active] 595496003451 catalytic residue [active] 595496003452 hypothetical protein; Provisional; Region: PRK10692 595496003453 putative transporter; Provisional; Region: PRK11660 595496003454 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 595496003455 Sulfate transporter family; Region: Sulfate_transp; pfam00916 595496003456 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 595496003457 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 595496003458 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 595496003459 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 595496003460 active site 595496003461 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 595496003462 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 595496003463 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 595496003464 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 595496003465 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 595496003466 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 595496003467 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 595496003468 tRNA; other site 595496003469 putative tRNA binding site [nucleotide binding]; other site 595496003470 putative NADP binding site [chemical binding]; other site 595496003471 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 595496003472 peptide chain release factor 1; Validated; Region: prfA; PRK00591 595496003473 This domain is found in peptide chain release factors; Region: PCRF; smart00937 595496003474 RF-1 domain; Region: RF-1; pfam00472 595496003475 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 595496003476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 595496003477 hypothetical protein; Provisional; Region: PRK10278 595496003478 hypothetical protein; Provisional; Region: PRK10941 595496003479 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 595496003480 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 595496003481 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 595496003482 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 595496003483 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 595496003484 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 595496003485 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 595496003486 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 595496003487 cation transport regulator; Reviewed; Region: chaB; PRK09582 595496003488 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 595496003489 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 595496003490 putative active site pocket [active] 595496003491 dimerization interface [polypeptide binding]; other site 595496003492 putative catalytic residue [active] 595496003493 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 595496003494 putative invasin; Provisional; Region: PRK10177 595496003495 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 595496003496 transcriptional regulator NarL; Provisional; Region: PRK10651 595496003497 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 595496003498 active site 595496003499 phosphorylation site [posttranslational modification] 595496003500 intermolecular recognition site; other site 595496003501 dimerization interface [polypeptide binding]; other site 595496003502 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 595496003503 DNA binding residues [nucleotide binding] 595496003504 dimerization interface [polypeptide binding]; other site 595496003505 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 595496003506 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 595496003507 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 595496003508 dimerization interface [polypeptide binding]; other site 595496003509 Histidine kinase; Region: HisKA_3; pfam07730 595496003510 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 595496003511 ATP binding site [chemical binding]; other site 595496003512 Mg2+ binding site [ion binding]; other site 595496003513 G-X-G motif; other site 595496003514 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 595496003515 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 595496003516 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 595496003517 [4Fe-4S] binding site [ion binding]; other site 595496003518 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 595496003519 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 595496003520 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 595496003521 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 595496003522 molybdopterin cofactor binding site; other site 595496003523 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 595496003524 4Fe-4S binding domain; Region: Fer4; cl02805 595496003525 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 595496003526 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 595496003527 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 595496003528 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 595496003529 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 595496003530 putative active site [active] 595496003531 putative substrate binding site [chemical binding]; other site 595496003532 putative cosubstrate binding site; other site 595496003533 catalytic site [active] 595496003534 SEC-C motif; Region: SEC-C; pfam02810 595496003535 hypothetical protein; Provisional; Region: PRK04233 595496003536 hypothetical protein; Provisional; Region: PRK10279 595496003537 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 595496003538 active site 595496003539 nucleophile elbow; other site 595496003540 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 595496003541 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 595496003542 response regulator of RpoS; Provisional; Region: PRK10693 595496003543 active site 595496003544 phosphorylation site [posttranslational modification] 595496003545 intermolecular recognition site; other site 595496003546 dimerization interface [polypeptide binding]; other site 595496003547 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 595496003548 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 595496003549 active site 595496003550 tetramer interface; other site 595496003551 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 595496003552 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 595496003553 thymidine kinase; Provisional; Region: PRK04296 595496003554 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 595496003555 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 595496003556 putative catalytic cysteine [active] 595496003557 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 595496003558 putative active site [active] 595496003559 metal binding site [ion binding]; metal-binding site 595496003560 hypothetical protein; Provisional; Region: PRK11111 595496003561 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 595496003562 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 595496003563 peptide binding site [polypeptide binding]; other site 595496003564 potential frameshift: common BLAST hit: gi|188574206|ref|YP_001919378.1| InsL 595496003565 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 595496003566 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 595496003567 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 595496003568 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 595496003569 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496003570 dimer interface [polypeptide binding]; other site 595496003571 conserved gate region; other site 595496003572 putative PBP binding loops; other site 595496003573 ABC-ATPase subunit interface; other site 595496003574 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 595496003575 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 595496003576 Walker A/P-loop; other site 595496003577 ATP binding site [chemical binding]; other site 595496003578 Q-loop/lid; other site 595496003579 ABC transporter signature motif; other site 595496003580 Walker B; other site 595496003581 D-loop; other site 595496003582 H-loop/switch region; other site 595496003583 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 595496003584 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 595496003585 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 595496003586 Walker A/P-loop; other site 595496003587 ATP binding site [chemical binding]; other site 595496003588 Q-loop/lid; other site 595496003589 ABC transporter signature motif; other site 595496003590 Walker B; other site 595496003591 D-loop; other site 595496003592 H-loop/switch region; other site 595496003593 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 595496003594 dsDNA-mimic protein; Reviewed; Region: PRK05094 595496003595 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 595496003596 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 595496003597 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 595496003598 putative active site [active] 595496003599 catalytic site [active] 595496003600 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 595496003601 putative active site [active] 595496003602 catalytic site [active] 595496003603 voltage-gated potassium channel; Provisional; Region: PRK10537 595496003604 Ion channel; Region: Ion_trans_2; pfam07885 595496003605 TrkA-N domain; Region: TrkA_N; pfam02254 595496003606 YciI-like protein; Reviewed; Region: PRK11370 595496003607 transport protein TonB; Provisional; Region: PRK10819 595496003608 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 595496003609 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 595496003610 intracellular septation protein A; Reviewed; Region: PRK00259 595496003611 hypothetical protein; Provisional; Region: PRK02868 595496003612 outer membrane protein W; Provisional; Region: PRK10959 595496003613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 595496003614 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 595496003615 dimerization interface [polypeptide binding]; other site 595496003616 metal binding site [ion binding]; metal-binding site 595496003617 General stress protein [General function prediction only]; Region: GsiB; COG3729 595496003618 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 595496003619 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 595496003620 substrate binding site [chemical binding]; other site 595496003621 active site 595496003622 catalytic residues [active] 595496003623 heterodimer interface [polypeptide binding]; other site 595496003624 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 595496003625 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 595496003626 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496003627 catalytic residue [active] 595496003628 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 595496003629 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 595496003630 active site 595496003631 ribulose/triose binding site [chemical binding]; other site 595496003632 phosphate binding site [ion binding]; other site 595496003633 substrate (anthranilate) binding pocket [chemical binding]; other site 595496003634 product (indole) binding pocket [chemical binding]; other site 595496003635 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 595496003636 active site 595496003637 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 595496003638 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 595496003639 glutamine binding [chemical binding]; other site 595496003640 catalytic triad [active] 595496003641 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 595496003642 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 595496003643 anthranilate synthase component I; Provisional; Region: PRK13564 595496003644 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 595496003645 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 595496003646 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 595496003647 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 595496003648 active site 595496003649 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 595496003650 hypothetical protein; Provisional; Region: PRK11630 595496003651 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 595496003652 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 595496003653 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 595496003654 RNA binding surface [nucleotide binding]; other site 595496003655 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 595496003656 probable active site [active] 595496003657 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 595496003658 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 595496003659 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 595496003660 homodimer interface [polypeptide binding]; other site 595496003661 Walker A motif; other site 595496003662 ATP binding site [chemical binding]; other site 595496003663 hydroxycobalamin binding site [chemical binding]; other site 595496003664 Walker B motif; other site 595496003665 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 595496003666 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 595496003667 NADP binding site [chemical binding]; other site 595496003668 homodimer interface [polypeptide binding]; other site 595496003669 active site 595496003670 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 595496003671 putative inner membrane peptidase; Provisional; Region: PRK11778 595496003672 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 595496003673 tandem repeat interface [polypeptide binding]; other site 595496003674 oligomer interface [polypeptide binding]; other site 595496003675 active site residues [active] 595496003676 hypothetical protein; Provisional; Region: PRK11037 595496003677 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 595496003678 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 595496003679 active site 595496003680 interdomain interaction site; other site 595496003681 putative metal-binding site [ion binding]; other site 595496003682 nucleotide binding site [chemical binding]; other site 595496003683 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 595496003684 domain I; other site 595496003685 DNA binding groove [nucleotide binding] 595496003686 phosphate binding site [ion binding]; other site 595496003687 domain II; other site 595496003688 domain III; other site 595496003689 nucleotide binding site [chemical binding]; other site 595496003690 catalytic site [active] 595496003691 domain IV; other site 595496003692 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 595496003693 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 595496003694 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 595496003695 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 595496003696 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 595496003697 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496003698 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 595496003699 substrate binding site [chemical binding]; other site 595496003700 putative dimerization interface [polypeptide binding]; other site 595496003701 aconitate hydratase; Validated; Region: PRK09277 595496003702 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 595496003703 substrate binding site [chemical binding]; other site 595496003704 ligand binding site [chemical binding]; other site 595496003705 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 595496003706 substrate binding site [chemical binding]; other site 595496003707 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 595496003708 dimerization interface [polypeptide binding]; other site 595496003709 active site 595496003710 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 595496003711 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 595496003712 active site 595496003713 Predicted membrane protein [Function unknown]; Region: COG3771 595496003714 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 595496003715 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 595496003716 TPR motif; other site 595496003717 binding surface 595496003718 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 595496003719 binding surface 595496003720 TPR motif; other site 595496003721 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 595496003722 active site 595496003723 dimer interface [polypeptide binding]; other site 595496003724 translation initiation factor Sui1; Validated; Region: PRK06824 595496003725 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 595496003726 putative rRNA binding site [nucleotide binding]; other site 595496003727 lipoprotein; Provisional; Region: PRK10540 595496003728 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 595496003729 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 595496003730 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 595496003731 hypothetical protein; Provisional; Region: PRK13658 595496003732 RNase II stability modulator; Provisional; Region: PRK10060 595496003733 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 595496003734 putative active site [active] 595496003735 heme pocket [chemical binding]; other site 595496003736 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 595496003737 metal binding site [ion binding]; metal-binding site 595496003738 active site 595496003739 I-site; other site 595496003740 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 595496003741 exoribonuclease II; Provisional; Region: PRK05054 595496003742 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 595496003743 RNB domain; Region: RNB; pfam00773 595496003744 S1 RNA binding domain; Region: S1; pfam00575 595496003745 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 595496003746 Uncharacterized conserved protein [Function unknown]; Region: COG2128 595496003747 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 595496003748 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 595496003749 NAD binding site [chemical binding]; other site 595496003750 homotetramer interface [polypeptide binding]; other site 595496003751 homodimer interface [polypeptide binding]; other site 595496003752 substrate binding site [chemical binding]; other site 595496003753 active site 595496003754 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 595496003755 putative active site [active] 595496003756 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 595496003757 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 595496003758 Walker A/P-loop; other site 595496003759 ATP binding site [chemical binding]; other site 595496003760 Q-loop/lid; other site 595496003761 ABC transporter signature motif; other site 595496003762 Walker B; other site 595496003763 D-loop; other site 595496003764 H-loop/switch region; other site 595496003765 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 595496003766 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 595496003767 Walker A/P-loop; other site 595496003768 ATP binding site [chemical binding]; other site 595496003769 Q-loop/lid; other site 595496003770 ABC transporter signature motif; other site 595496003771 Walker B; other site 595496003772 D-loop; other site 595496003773 H-loop/switch region; other site 595496003774 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 595496003775 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 595496003776 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 595496003777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496003778 dimer interface [polypeptide binding]; other site 595496003779 conserved gate region; other site 595496003780 putative PBP binding loops; other site 595496003781 ABC-ATPase subunit interface; other site 595496003782 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 595496003783 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496003784 dimer interface [polypeptide binding]; other site 595496003785 conserved gate region; other site 595496003786 putative PBP binding loops; other site 595496003787 ABC-ATPase subunit interface; other site 595496003788 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 595496003789 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 595496003790 peptide binding site [polypeptide binding]; other site 595496003791 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 595496003792 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 595496003793 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 595496003794 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 595496003795 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 595496003796 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 595496003797 catalytic triad [active] 595496003798 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 595496003799 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 595496003800 non-specific DNA binding site [nucleotide binding]; other site 595496003801 salt bridge; other site 595496003802 sequence-specific DNA binding site [nucleotide binding]; other site 595496003803 Cupin domain; Region: Cupin_2; pfam07883 595496003804 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 595496003805 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 595496003806 NAD(P) binding site [chemical binding]; other site 595496003807 catalytic residues [active] 595496003808 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 595496003809 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 595496003810 4-aminobutyrate transaminase; Provisional; Region: PRK09792 595496003811 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 595496003812 inhibitor-cofactor binding pocket; inhibition site 595496003813 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496003814 catalytic residue [active] 595496003815 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 595496003816 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 595496003817 Walker A motif; other site 595496003818 ATP binding site [chemical binding]; other site 595496003819 Walker B motif; other site 595496003820 arginine finger; other site 595496003821 phage shock protein PspA; Provisional; Region: PRK10698 595496003822 phage shock protein B; Provisional; Region: pspB; PRK09458 595496003823 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 595496003824 phage shock protein C; Region: phageshock_pspC; TIGR02978 595496003825 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 595496003826 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 595496003827 active site residue [active] 595496003828 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 595496003829 sucrose phosphorylase; Provisional; Region: PRK13840 595496003830 active site 595496003831 homodimer interface [polypeptide binding]; other site 595496003832 catalytic site [active] 595496003833 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 595496003834 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 595496003835 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 595496003836 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496003837 dimer interface [polypeptide binding]; other site 595496003838 conserved gate region; other site 595496003839 putative PBP binding loops; other site 595496003840 ABC-ATPase subunit interface; other site 595496003841 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 595496003842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496003843 dimer interface [polypeptide binding]; other site 595496003844 conserved gate region; other site 595496003845 putative PBP binding loops; other site 595496003846 ABC-ATPase subunit interface; other site 595496003847 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 595496003848 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 595496003849 putative NAD(P) binding site [chemical binding]; other site 595496003850 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 595496003851 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 595496003852 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 595496003853 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 595496003854 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 595496003855 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 595496003856 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 595496003857 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 595496003858 beta-phosphoglucomutase; Region: bPGM; TIGR01990 595496003859 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 595496003860 motif II; other site 595496003861 Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381 595496003862 Transcriptional regulators [Transcription]; Region: PurR; COG1609 595496003863 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 595496003864 DNA binding site [nucleotide binding] 595496003865 domain linker motif; other site 595496003866 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 595496003867 putative dimerization interface [polypeptide binding]; other site 595496003868 putative ligand binding site [chemical binding]; other site 595496003869 Predicted ATPase [General function prediction only]; Region: COG3106 595496003870 hypothetical protein; Provisional; Region: PRK05415 595496003871 TIGR01620 family protein; Region: hyp_HI0043 595496003872 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 595496003873 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 595496003874 putative aromatic amino acid binding site; other site 595496003875 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 595496003876 Walker A motif; other site 595496003877 ATP binding site [chemical binding]; other site 595496003878 Walker B motif; other site 595496003879 arginine finger; other site 595496003880 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 595496003881 dimer interface [polypeptide binding]; other site 595496003882 catalytic triad [active] 595496003883 peroxidatic and resolving cysteines [active] 595496003884 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 595496003885 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 595496003886 active site 595496003887 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 595496003888 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 595496003889 putative active site [active] 595496003890 Zn binding site [ion binding]; other site 595496003891 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 595496003892 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 595496003893 Transcriptional regulator [Transcription]; Region: LysR; COG0583 595496003894 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496003895 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 595496003896 putative effector binding pocket; other site 595496003897 putative dimerization interface [polypeptide binding]; other site 595496003898 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 595496003899 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 595496003900 peptide binding site [polypeptide binding]; other site 595496003901 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 595496003902 Mechanosensitive ion channel; Region: MS_channel; pfam00924 595496003903 Transposase domain (DUF772); Region: DUF772; pfam05598 595496003904 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 595496003905 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 595496003906 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 595496003907 universal stress protein UspE; Provisional; Region: PRK11175 595496003908 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 595496003909 Ligand Binding Site [chemical binding]; other site 595496003910 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 595496003911 Ligand Binding Site [chemical binding]; other site 595496003912 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 595496003913 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 595496003914 ligand binding site [chemical binding]; other site 595496003915 flexible hinge region; other site 595496003916 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 595496003917 putative switch regulator; other site 595496003918 non-specific DNA interactions [nucleotide binding]; other site 595496003919 DNA binding site [nucleotide binding] 595496003920 sequence specific DNA binding site [nucleotide binding]; other site 595496003921 putative cAMP binding site [chemical binding]; other site 595496003922 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 595496003923 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 595496003924 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 595496003925 DNA binding site [nucleotide binding] 595496003926 active site 595496003927 putative aminobenzoyl-glutamate transporter; Provisional; Region: abgT; PRK11339 595496003928 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 595496003929 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 595496003930 amidohydrolase; Region: amidohydrolases; TIGR01891 595496003931 putative metal binding site [ion binding]; other site 595496003932 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 595496003933 amidohydrolase; Region: amidohydrolases; TIGR01891 595496003934 putative metal binding site [ion binding]; other site 595496003935 dimer interface [polypeptide binding]; other site 595496003936 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 595496003937 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496003938 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 595496003939 putative substrate binding pocket [chemical binding]; other site 595496003940 putative dimerization interface [polypeptide binding]; other site 595496003941 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 595496003942 Smr domain; Region: Smr; pfam01713 595496003943 PAS domain S-box; Region: sensory_box; TIGR00229 595496003944 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 595496003945 putative active site [active] 595496003946 heme pocket [chemical binding]; other site 595496003947 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 595496003948 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 595496003949 metal binding site [ion binding]; metal-binding site 595496003950 active site 595496003951 I-site; other site 595496003952 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 595496003953 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 595496003954 Cl binding site [ion binding]; other site 595496003955 oligomer interface [polypeptide binding]; other site 595496003956 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 595496003957 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 595496003958 ATP binding site [chemical binding]; other site 595496003959 Mg++ binding site [ion binding]; other site 595496003960 motif III; other site 595496003961 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 595496003962 nucleotide binding region [chemical binding]; other site 595496003963 ATP-binding site [chemical binding]; other site 595496003964 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 595496003965 putative RNA binding site [nucleotide binding]; other site 595496003966 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 595496003967 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 595496003968 Ligand Binding Site [chemical binding]; other site 595496003969 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 595496003970 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 595496003971 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 595496003972 Int/Topo IB signature motif; other site 595496003973 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 595496003974 hypothetical protein; Provisional; Region: PRK09750 595496003975 restriction alleviation and modification protein; Reviewed; Region: lar; PRK09710 595496003976 recombination and repair protein RecT; Reviewed; Region: recT; PRK09846 595496003977 exonuclease VIII; Reviewed; Region: PRK09709 595496003978 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 595496003979 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 595496003980 hypothetical protein; Reviewed; Region: PRK09790 595496003981 FtsZ inhibitor protein; Reviewed; Region: kil; PRK11354 595496003982 Superinfection exclusion protein B; Region: SieB; pfam14163 595496003983 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 595496003984 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 595496003985 sequence-specific DNA binding site [nucleotide binding]; other site 595496003986 salt bridge; other site 595496003987 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 595496003988 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3756 595496003989 primosomal protein DnaI; Provisional; Region: PRK02854 595496003990 putative replication protein; Provisional; Region: PRK12377 595496003991 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 595496003992 Walker A motif; other site 595496003993 ATP binding site [chemical binding]; other site 595496003994 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 595496003995 Cation transport protein; Region: TrkH; cl17365 595496003996 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 595496003997 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 595496003998 ParB-like nuclease domain; Region: ParBc; pfam02195 595496003999 Transposase domain (DUF772); Region: DUF772; pfam05598 595496004000 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 595496004001 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 595496004002 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 595496004003 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 595496004004 Phage Tail Collar Domain; Region: Collar; pfam07484 595496004005 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 595496004006 multiple promoter invertase; Provisional; Region: mpi; PRK13413 595496004007 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 595496004008 catalytic residues [active] 595496004009 catalytic nucleophile [active] 595496004010 Presynaptic Site I dimer interface [polypeptide binding]; other site 595496004011 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 595496004012 Synaptic Flat tetramer interface [polypeptide binding]; other site 595496004013 Synaptic Site I dimer interface [polypeptide binding]; other site 595496004014 DNA binding site [nucleotide binding] 595496004015 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 595496004016 DNA-binding interface [nucleotide binding]; DNA binding site 595496004017 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 595496004018 Ligand Binding Site [chemical binding]; other site 595496004019 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 595496004020 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 595496004021 trimer interface [polypeptide binding]; other site 595496004022 eyelet of channel; other site 595496004023 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 595496004024 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 595496004025 dimer interface [polypeptide binding]; other site 595496004026 PYR/PP interface [polypeptide binding]; other site 595496004027 TPP binding site [chemical binding]; other site 595496004028 substrate binding site [chemical binding]; other site 595496004029 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 595496004030 Domain of unknown function; Region: EKR; smart00890 595496004031 4Fe-4S binding domain; Region: Fer4_6; pfam12837 595496004032 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 595496004033 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 595496004034 TPP-binding site [chemical binding]; other site 595496004035 dimer interface [polypeptide binding]; other site 595496004036 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 595496004037 Domain of unknown function (DUF333); Region: DUF333; pfam03891 595496004038 heat-inducible protein; Provisional; Region: PRK10449 595496004039 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 595496004040 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 595496004041 putative ligand binding site [chemical binding]; other site 595496004042 putative NAD binding site [chemical binding]; other site 595496004043 catalytic site [active] 595496004044 hypothetical protein; Provisional; Region: PRK10695 595496004045 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 595496004046 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 595496004047 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 595496004048 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 595496004049 Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; Region: ALDH_PADH_NahF; cd07113 595496004050 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 595496004051 NAD(P) binding site [chemical binding]; other site 595496004052 catalytic residues [active] 595496004053 tyramine oxidase; Provisional; Region: tynA; PRK14696 595496004054 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 595496004055 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 595496004056 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 595496004057 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 595496004058 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 595496004059 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 595496004060 substrate binding site [chemical binding]; other site 595496004061 dimer interface [polypeptide binding]; other site 595496004062 NADP binding site [chemical binding]; other site 595496004063 catalytic residues [active] 595496004064 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 595496004065 substrate binding site [chemical binding]; other site 595496004066 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 595496004067 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 595496004068 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 595496004069 phenylacetate-CoA oxygenase, PaaI subunit; Region: PA_CoA_Oxy3; TIGR02158 595496004070 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 595496004071 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 595496004072 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 595496004073 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 595496004074 FAD binding pocket [chemical binding]; other site 595496004075 FAD binding motif [chemical binding]; other site 595496004076 phosphate binding motif [ion binding]; other site 595496004077 beta-alpha-beta structure motif; other site 595496004078 NAD(p) ribose binding residues [chemical binding]; other site 595496004079 NAD binding pocket [chemical binding]; other site 595496004080 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 595496004081 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 595496004082 catalytic loop [active] 595496004083 iron binding site [ion binding]; other site 595496004084 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 595496004085 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 595496004086 substrate binding site [chemical binding]; other site 595496004087 oxyanion hole (OAH) forming residues; other site 595496004088 trimer interface [polypeptide binding]; other site 595496004089 enoyl-CoA hydratase; Provisional; Region: PRK08140 595496004090 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 595496004091 substrate binding site [chemical binding]; other site 595496004092 oxyanion hole (OAH) forming residues; other site 595496004093 trimer interface [polypeptide binding]; other site 595496004094 3-hydroxyacyl-CoA dehydrogenase PaaC; Region: PaaC-3OHAcCoADH; TIGR02279 595496004095 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 595496004096 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 595496004097 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 595496004098 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 595496004099 CoenzymeA binding site [chemical binding]; other site 595496004100 subunit interaction site [polypeptide binding]; other site 595496004101 PHB binding site; other site 595496004102 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 595496004103 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 595496004104 dimer interface [polypeptide binding]; other site 595496004105 active site 595496004106 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 595496004107 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 595496004108 active site 595496004109 AMP binding site [chemical binding]; other site 595496004110 homodimer interface [polypeptide binding]; other site 595496004111 acyl-activating enzyme (AAE) consensus motif; other site 595496004112 CoA binding site [chemical binding]; other site 595496004113 PaaX-like protein; Region: PaaX; pfam07848 595496004114 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 595496004115 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 595496004116 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 595496004117 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 595496004118 putative trimer interface [polypeptide binding]; other site 595496004119 putative metal binding site [ion binding]; other site 595496004120 IS2 transposase TnpB; Reviewed; Region: PRK09409 595496004121 HTH-like domain; Region: HTH_21; pfam13276 595496004122 Integrase core domain; Region: rve; pfam00665 595496004123 Integrase core domain; Region: rve_3; pfam13683 595496004124 IS2 repressor TnpA; Reviewed; Region: PRK09413 595496004125 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 595496004126 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 595496004127 Helix-turn-helix domain; Region: HTH_38; pfam13936 595496004128 Integrase core domain; Region: rve; pfam00665 595496004129 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 595496004130 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 595496004131 active site 595496004132 catalytic tetrad [active] 595496004133 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 595496004134 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 595496004135 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 595496004136 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 595496004137 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 595496004138 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 595496004139 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 595496004140 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 595496004141 S-adenosylmethionine binding site [chemical binding]; other site 595496004142 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 595496004143 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 595496004144 active site 595496004145 Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or...; Region: DSPc; cd00127 595496004146 active site 595496004147 catalytic residues [active] 595496004148 azoreductase; Reviewed; Region: PRK00170 595496004149 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 595496004150 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 595496004151 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 595496004152 ATP binding site [chemical binding]; other site 595496004153 putative Mg++ binding site [ion binding]; other site 595496004154 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 595496004155 nucleotide binding region [chemical binding]; other site 595496004156 ATP-binding site [chemical binding]; other site 595496004157 Helicase associated domain (HA2); Region: HA2; pfam04408 595496004158 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 595496004159 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 595496004160 Uncharacterized conserved protein [Function unknown]; Region: COG1434 595496004161 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 595496004162 putative active site [active] 595496004163 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 595496004164 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 595496004165 NAD binding site [chemical binding]; other site 595496004166 catalytic residues [active] 595496004167 substrate binding site [chemical binding]; other site 595496004168 cytochrome b561; Provisional; Region: PRK11513 595496004169 hypothetical protein; Provisional; Region: PRK10040 595496004170 small toxic polypeptide; Provisional; Region: PRK09738 595496004171 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 595496004172 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 595496004173 dimer interface [polypeptide binding]; other site 595496004174 ligand binding site [chemical binding]; other site 595496004175 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 595496004176 dimerization interface [polypeptide binding]; other site 595496004177 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 595496004178 dimer interface [polypeptide binding]; other site 595496004179 putative CheW interface [polypeptide binding]; other site 595496004180 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 595496004181 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496004182 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 595496004183 dimerization interface [polypeptide binding]; other site 595496004184 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 595496004185 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 595496004186 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 595496004187 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 595496004188 hypothetical protein; Provisional; Region: PRK11415 595496004189 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 595496004190 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 595496004191 Coenzyme A binding pocket [chemical binding]; other site 595496004192 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 595496004193 putative trimer interface [polypeptide binding]; other site 595496004194 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 595496004195 putative CoA binding site [chemical binding]; other site 595496004196 putative trimer interface [polypeptide binding]; other site 595496004197 putative CoA binding site [chemical binding]; other site 595496004198 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 595496004199 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 595496004200 gating phenylalanine in ion channel; other site 595496004201 tellurite resistance protein TehB; Provisional; Region: PRK11207 595496004202 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 595496004203 S-adenosylmethionine binding site [chemical binding]; other site 595496004204 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 595496004205 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 595496004206 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 595496004207 Probable transposase; Region: OrfB_IS605; pfam01385 595496004208 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 595496004209 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 595496004210 benzoate transporter; Region: benE; TIGR00843 595496004211 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 595496004212 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 595496004213 non-specific DNA binding site [nucleotide binding]; other site 595496004214 salt bridge; other site 595496004215 sequence-specific DNA binding site [nucleotide binding]; other site 595496004216 Cupin domain; Region: Cupin_2; pfam07883 595496004217 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 595496004218 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 595496004219 Peptidase family U32; Region: Peptidase_U32; pfam01136 595496004220 Collagenase; Region: DUF3656; pfam12392 595496004221 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 595496004222 YcfA-like protein; Region: YcfA; pfam07927 595496004223 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 595496004224 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 595496004225 sequence-specific DNA binding site [nucleotide binding]; other site 595496004226 salt bridge; other site 595496004227 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 595496004228 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 595496004229 DNA-binding site [nucleotide binding]; DNA binding site 595496004230 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 595496004231 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496004232 homodimer interface [polypeptide binding]; other site 595496004233 catalytic residue [active] 595496004234 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 595496004235 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 595496004236 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 595496004237 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 595496004238 Walker A/P-loop; other site 595496004239 ATP binding site [chemical binding]; other site 595496004240 Q-loop/lid; other site 595496004241 ABC transporter signature motif; other site 595496004242 Walker B; other site 595496004243 D-loop; other site 595496004244 H-loop/switch region; other site 595496004245 TOBE domain; Region: TOBE_2; pfam08402 595496004246 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496004247 dimer interface [polypeptide binding]; other site 595496004248 conserved gate region; other site 595496004249 putative PBP binding loops; other site 595496004250 ABC-ATPase subunit interface; other site 595496004251 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 595496004252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496004253 ABC-ATPase subunit interface; other site 595496004254 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 595496004255 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 595496004256 tetrameric interface [polypeptide binding]; other site 595496004257 NAD binding site [chemical binding]; other site 595496004258 catalytic residues [active] 595496004259 substrate binding site [chemical binding]; other site 595496004260 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 595496004261 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 595496004262 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 595496004263 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 595496004264 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 595496004265 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 595496004266 Prostaglandin dehydrogenases; Region: PGDH; cd05288 595496004267 NAD(P) binding site [chemical binding]; other site 595496004268 substrate binding site [chemical binding]; other site 595496004269 dimer interface [polypeptide binding]; other site 595496004270 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 595496004271 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 595496004272 DNA-binding site [nucleotide binding]; DNA binding site 595496004273 FCD domain; Region: FCD; pfam07729 595496004274 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 595496004275 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 595496004276 N-terminal plug; other site 595496004277 ligand-binding site [chemical binding]; other site 595496004278 PQQ-like domain; Region: PQQ_2; pfam13360 595496004279 L-asparagine permease; Provisional; Region: PRK15049 595496004280 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 595496004281 C-terminal domain interface [polypeptide binding]; other site 595496004282 GSH binding site (G-site) [chemical binding]; other site 595496004283 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 595496004284 dimer interface [polypeptide binding]; other site 595496004285 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 595496004286 dimer interface [polypeptide binding]; other site 595496004287 N-terminal domain interface [polypeptide binding]; other site 595496004288 substrate binding pocket (H-site) [chemical binding]; other site 595496004289 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 595496004290 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 595496004291 Transposase [DNA replication, recombination, and repair]; Region: COG5433 595496004292 Transposase [DNA replication, recombination, and repair]; Region: COG5433 595496004293 4-oxalocrotonate tautomerase; Provisional; Region: PRK01271 595496004294 active site 1 [active] 595496004295 dimer interface [polypeptide binding]; other site 595496004296 hexamer interface [polypeptide binding]; other site 595496004297 active site 2 [active] 595496004298 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 595496004299 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 595496004300 hypothetical protein; Provisional; Region: PRK10281 595496004301 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 595496004302 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 595496004303 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 595496004304 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 595496004305 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 595496004306 [4Fe-4S] binding site [ion binding]; other site 595496004307 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 595496004308 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 595496004309 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 595496004310 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 595496004311 molybdopterin cofactor binding site; other site 595496004312 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 595496004313 aromatic amino acid exporter; Provisional; Region: PRK11689 595496004314 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 595496004315 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 595496004316 [4Fe-4S] binding site [ion binding]; other site 595496004317 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 595496004318 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 595496004319 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 595496004320 molybdopterin cofactor binding site; other site 595496004321 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 595496004322 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 595496004323 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 595496004324 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 595496004325 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 595496004326 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 595496004327 non-specific DNA binding site [nucleotide binding]; other site 595496004328 salt bridge; other site 595496004329 sequence-specific DNA binding site [nucleotide binding]; other site 595496004330 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 595496004331 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 595496004332 NAD binding site [chemical binding]; other site 595496004333 substrate binding site [chemical binding]; other site 595496004334 catalytic Zn binding site [ion binding]; other site 595496004335 tetramer interface [polypeptide binding]; other site 595496004336 structural Zn binding site [ion binding]; other site 595496004337 malate dehydrogenase; Provisional; Region: PRK13529 595496004338 Malic enzyme, N-terminal domain; Region: malic; pfam00390 595496004339 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 595496004340 NAD(P) binding site [chemical binding]; other site 595496004341 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 595496004342 Putative biofilm-dependent modulation protein; Region: BDM; cl11581 595496004343 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 595496004344 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 595496004345 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 595496004346 Walker A/P-loop; other site 595496004347 ATP binding site [chemical binding]; other site 595496004348 Q-loop/lid; other site 595496004349 ABC transporter signature motif; other site 595496004350 Walker B; other site 595496004351 D-loop; other site 595496004352 H-loop/switch region; other site 595496004353 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 595496004354 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 595496004355 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 595496004356 Walker A/P-loop; other site 595496004357 ATP binding site [chemical binding]; other site 595496004358 Q-loop/lid; other site 595496004359 ABC transporter signature motif; other site 595496004360 Walker B; other site 595496004361 D-loop; other site 595496004362 H-loop/switch region; other site 595496004363 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 595496004364 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 595496004365 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 595496004366 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496004367 dimer interface [polypeptide binding]; other site 595496004368 conserved gate region; other site 595496004369 putative PBP binding loops; other site 595496004370 ABC-ATPase subunit interface; other site 595496004371 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 595496004372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496004373 dimer interface [polypeptide binding]; other site 595496004374 conserved gate region; other site 595496004375 putative PBP binding loops; other site 595496004376 ABC-ATPase subunit interface; other site 595496004377 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 595496004378 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 595496004379 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 595496004380 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 595496004381 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 595496004382 putative active site [active] 595496004383 heme pocket [chemical binding]; other site 595496004384 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 595496004385 putative active site [active] 595496004386 heme pocket [chemical binding]; other site 595496004387 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 595496004388 metal binding site [ion binding]; metal-binding site 595496004389 active site 595496004390 I-site; other site 595496004391 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 595496004392 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 595496004393 heme-binding site [chemical binding]; other site 595496004394 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 595496004395 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 595496004396 metal binding site [ion binding]; metal-binding site 595496004397 active site 595496004398 I-site; other site 595496004399 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 595496004400 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 595496004401 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 595496004402 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 595496004403 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496004404 catalytic residue [active] 595496004405 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 595496004406 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 595496004407 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 595496004408 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 595496004409 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 595496004410 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 595496004411 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 595496004412 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 595496004413 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 595496004414 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 595496004415 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 595496004416 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 595496004417 FeS/SAM binding site; other site 595496004418 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 595496004419 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 595496004420 Sulfatase; Region: Sulfatase; pfam00884 595496004421 transcriptional regulator YdeO; Provisional; Region: PRK09940 595496004422 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 595496004423 putative oxidoreductase; Provisional; Region: PRK09939 595496004424 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 595496004425 putative molybdopterin cofactor binding site [chemical binding]; other site 595496004426 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 595496004427 putative molybdopterin cofactor binding site; other site 595496004428 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 595496004429 mannosyl binding site [chemical binding]; other site 595496004430 Fimbrial protein; Region: Fimbrial; pfam00419 595496004431 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 595496004432 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 595496004433 HipA N-terminal domain; Region: Couple_hipA; pfam13657 595496004434 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 595496004435 HipA-like N-terminal domain; Region: HipA_N; pfam07805 595496004436 HipA-like C-terminal domain; Region: HipA_C; pfam07804 595496004437 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 595496004438 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 595496004439 non-specific DNA binding site [nucleotide binding]; other site 595496004440 salt bridge; other site 595496004441 sequence-specific DNA binding site [nucleotide binding]; other site 595496004442 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 595496004443 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 595496004444 Autotransporter beta-domain; Region: Autotransporter; pfam03797 595496004445 putative lipoprotein; Provisional; Region: PRK09707 595496004446 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 595496004447 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 595496004448 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 595496004449 putative N- and C-terminal domain interface [polypeptide binding]; other site 595496004450 putative active site [active] 595496004451 putative MgATP binding site [chemical binding]; other site 595496004452 catalytic site [active] 595496004453 metal binding site [ion binding]; metal-binding site 595496004454 putative carbohydrate binding site [chemical binding]; other site 595496004455 transcriptional regulator LsrR; Provisional; Region: PRK15418 595496004456 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 595496004457 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 595496004458 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 595496004459 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 595496004460 Walker A/P-loop; other site 595496004461 ATP binding site [chemical binding]; other site 595496004462 Q-loop/lid; other site 595496004463 ABC transporter signature motif; other site 595496004464 Walker B; other site 595496004465 D-loop; other site 595496004466 H-loop/switch region; other site 595496004467 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 595496004468 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 595496004469 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 595496004470 TM-ABC transporter signature motif; other site 595496004471 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 595496004472 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 595496004473 TM-ABC transporter signature motif; other site 595496004474 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 595496004475 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 595496004476 ligand binding site [chemical binding]; other site 595496004477 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 595496004478 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 595496004479 putative active site; other site 595496004480 catalytic residue [active] 595496004481 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 595496004482 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 595496004483 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 595496004484 S-adenosylmethionine binding site [chemical binding]; other site 595496004485 Predicted membrane protein [Function unknown]; Region: COG3781 595496004486 altronate oxidoreductase; Provisional; Region: PRK03643 595496004487 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 595496004488 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 595496004489 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 595496004490 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 595496004491 metal binding site [ion binding]; metal-binding site 595496004492 active site 595496004493 I-site; other site 595496004494 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 595496004495 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 595496004496 glutaminase; Provisional; Region: PRK00971 595496004497 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 595496004498 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 595496004499 NAD(P) binding site [chemical binding]; other site 595496004500 catalytic residues [active] 595496004501 Transcriptional regulator [Transcription]; Region: LysR; COG0583 595496004502 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496004503 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 595496004504 putative dimerization interface [polypeptide binding]; other site 595496004505 putative arabinose transporter; Provisional; Region: PRK03545 595496004506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496004507 putative substrate translocation pore; other site 595496004508 inner membrane protein; Provisional; Region: PRK10995 595496004509 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 595496004510 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 595496004511 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 595496004512 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 595496004513 hypothetical protein; Provisional; Region: PRK10106 595496004514 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 595496004515 EamA-like transporter family; Region: EamA; pfam00892 595496004516 EamA-like transporter family; Region: EamA; pfam00892 595496004517 putative transporter; Provisional; Region: PRK10054 595496004518 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496004519 putative substrate translocation pore; other site 595496004520 diguanylate cyclase; Provisional; Region: PRK09894 595496004521 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 595496004522 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 595496004523 metal binding site [ion binding]; metal-binding site 595496004524 active site 595496004525 I-site; other site 595496004526 hypothetical protein; Provisional; Region: PRK10053 595496004527 hypothetical protein; Validated; Region: PRK03657 595496004528 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 595496004529 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 595496004530 active site 595496004531 Zn binding site [ion binding]; other site 595496004532 malonic semialdehyde reductase; Provisional; Region: PRK10538 595496004533 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 595496004534 putative NAD(P) binding site [chemical binding]; other site 595496004535 homodimer interface [polypeptide binding]; other site 595496004536 homotetramer interface [polypeptide binding]; other site 595496004537 active site 595496004538 Transcriptional regulators [Transcription]; Region: GntR; COG1802 595496004539 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 595496004540 DNA-binding site [nucleotide binding]; DNA binding site 595496004541 FCD domain; Region: FCD; pfam07729 595496004542 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 595496004543 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 595496004544 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 595496004545 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 595496004546 multiple promoter invertase; Provisional; Region: mpi; PRK13413 595496004547 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 595496004548 catalytic residues [active] 595496004549 catalytic nucleophile [active] 595496004550 Presynaptic Site I dimer interface [polypeptide binding]; other site 595496004551 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 595496004552 Synaptic Flat tetramer interface [polypeptide binding]; other site 595496004553 Synaptic Site I dimer interface [polypeptide binding]; other site 595496004554 DNA binding site [nucleotide binding] 595496004555 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 595496004556 DNA-binding interface [nucleotide binding]; DNA binding site 595496004557 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 595496004558 Phage Tail Collar Domain; Region: Collar; pfam07484 595496004559 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 595496004560 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 595496004561 GnsA/GnsB family; Region: GnsAB; pfam08178 595496004562 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 595496004563 DNA-binding site [nucleotide binding]; DNA binding site 595496004564 RNA-binding motif; other site 595496004565 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 595496004566 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 595496004567 catalytic residues [active] 595496004568 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 595496004569 Lysis protein S; Region: Lysis_S; pfam04971 595496004570 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 595496004571 DNA-binding site [nucleotide binding]; DNA binding site 595496004572 RNA-binding motif; other site 595496004573 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 595496004574 DNA-binding site [nucleotide binding]; DNA binding site 595496004575 RNA-binding motif; other site 595496004576 Antitermination protein; Region: Antiterm; pfam03589 595496004577 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 595496004578 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 595496004579 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 595496004580 Protein of unknown function (DUF968); Region: DUF968; pfam06147 595496004581 Hok/gef family; Region: HOK_GEF; pfam01848 595496004582 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 595496004583 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 595496004584 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 595496004585 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 595496004586 transcriptional repressor DicA; Reviewed; Region: PRK09706 595496004587 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 595496004588 non-specific DNA binding site [nucleotide binding]; other site 595496004589 salt bridge; other site 595496004590 sequence-specific DNA binding site [nucleotide binding]; other site 595496004591 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 595496004592 DicB protein; Region: DicB; pfam05358 595496004593 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 595496004594 putative oxidoreductase; Provisional; Region: PRK10083 595496004595 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 595496004596 putative NAD(P) binding site [chemical binding]; other site 595496004597 catalytic Zn binding site [ion binding]; other site 595496004598 structural Zn binding site [ion binding]; other site 595496004599 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 595496004600 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 595496004601 putative active site pocket [active] 595496004602 putative metal binding site [ion binding]; other site 595496004603 hypothetical protein; Provisional; Region: PRK02237 595496004604 hypothetical protein; Provisional; Region: PRK13659 595496004605 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 595496004606 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 595496004607 Coenzyme A binding pocket [chemical binding]; other site 595496004608 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 595496004609 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 595496004610 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 595496004611 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 595496004612 putative [Fe4-S4] binding site [ion binding]; other site 595496004613 putative molybdopterin cofactor binding site [chemical binding]; other site 595496004614 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 595496004615 putative molybdopterin cofactor binding site; other site 595496004616 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 595496004617 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 595496004618 putative [Fe4-S4] binding site [ion binding]; other site 595496004619 putative molybdopterin cofactor binding site [chemical binding]; other site 595496004620 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 595496004621 putative molybdopterin cofactor binding site; other site 595496004622 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 595496004623 4Fe-4S binding domain; Region: Fer4; cl02805 595496004624 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 595496004625 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 595496004626 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 595496004627 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 595496004628 Cl- selectivity filter; other site 595496004629 Cl- binding residues [ion binding]; other site 595496004630 pore gating glutamate residue; other site 595496004631 dimer interface [polypeptide binding]; other site 595496004632 putative dithiobiotin synthetase; Provisional; Region: PRK12374 595496004633 AAA domain; Region: AAA_26; pfam13500 595496004634 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 595496004635 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 595496004636 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 595496004637 nucleotide binding site [chemical binding]; other site 595496004638 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 595496004639 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496004640 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 595496004641 dimerization interface [polypeptide binding]; other site 595496004642 substrate binding pocket [chemical binding]; other site 595496004643 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 595496004644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496004645 putative substrate translocation pore; other site 595496004646 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 595496004647 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 595496004648 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 595496004649 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 595496004650 Domain of unknown function DUF20; Region: UPF0118; pfam01594 595496004651 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 595496004652 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 595496004653 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 595496004654 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 595496004655 ligand binding site [chemical binding]; other site 595496004656 homodimer interface [polypeptide binding]; other site 595496004657 NAD(P) binding site [chemical binding]; other site 595496004658 trimer interface B [polypeptide binding]; other site 595496004659 trimer interface A [polypeptide binding]; other site 595496004660 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 595496004661 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 595496004662 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 595496004663 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 595496004664 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 595496004665 Spore germination protein; Region: Spore_permease; cl17796 595496004666 dihydromonapterin reductase; Provisional; Region: PRK06483 595496004667 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 595496004668 NADP binding site [chemical binding]; other site 595496004669 substrate binding pocket [chemical binding]; other site 595496004670 active site 595496004671 GlpM protein; Region: GlpM; pfam06942 595496004672 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 595496004673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 595496004674 active site 595496004675 phosphorylation site [posttranslational modification] 595496004676 intermolecular recognition site; other site 595496004677 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 595496004678 DNA binding site [nucleotide binding] 595496004679 sensor protein RstB; Provisional; Region: PRK10604 595496004680 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 595496004681 dimerization interface [polypeptide binding]; other site 595496004682 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 595496004683 dimer interface [polypeptide binding]; other site 595496004684 phosphorylation site [posttranslational modification] 595496004685 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 595496004686 ATP binding site [chemical binding]; other site 595496004687 Mg2+ binding site [ion binding]; other site 595496004688 G-X-G motif; other site 595496004689 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 595496004690 fumarate hydratase; Reviewed; Region: fumC; PRK00485 595496004691 Class II fumarases; Region: Fumarase_classII; cd01362 595496004692 active site 595496004693 tetramer interface [polypeptide binding]; other site 595496004694 fumarate hydratase; Provisional; Region: PRK15389 595496004695 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 595496004696 Fumarase C-terminus; Region: Fumerase_C; pfam05683 595496004697 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 595496004698 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 595496004699 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 595496004700 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 595496004701 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 595496004702 putative outer membrane porin protein; Provisional; Region: PRK11379 595496004703 beta-D-glucuronidase; Provisional; Region: PRK10150 595496004704 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 595496004705 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 595496004706 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 595496004707 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 595496004708 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 595496004709 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 595496004710 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 595496004711 NAD binding site [chemical binding]; other site 595496004712 substrate binding site [chemical binding]; other site 595496004713 homotetramer interface [polypeptide binding]; other site 595496004714 homodimer interface [polypeptide binding]; other site 595496004715 active site 595496004716 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 595496004717 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 595496004718 DNA binding site [nucleotide binding] 595496004719 domain linker motif; other site 595496004720 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 595496004721 putative dimerization interface [polypeptide binding]; other site 595496004722 putative ligand binding site [chemical binding]; other site 595496004723 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 595496004724 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 595496004725 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 595496004726 active site turn [active] 595496004727 phosphorylation site [posttranslational modification] 595496004728 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 595496004729 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 595496004730 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496004731 homodimer interface [polypeptide binding]; other site 595496004732 catalytic residue [active] 595496004733 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 595496004734 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 595496004735 active site 595496004736 purine riboside binding site [chemical binding]; other site 595496004737 putative oxidoreductase; Provisional; Region: PRK11579 595496004738 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 595496004739 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 595496004740 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 595496004741 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 595496004742 electron transport complex protein RsxA; Provisional; Region: PRK05151 595496004743 electron transport complex protein RnfB; Provisional; Region: PRK05113 595496004744 Putative Fe-S cluster; Region: FeS; pfam04060 595496004745 4Fe-4S binding domain; Region: Fer4; pfam00037 595496004746 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 595496004747 SLBB domain; Region: SLBB; pfam10531 595496004748 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 595496004749 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 595496004750 electron transport complex protein RnfG; Validated; Region: PRK01908 595496004751 electron transport complex RsxE subunit; Provisional; Region: PRK12405 595496004752 endonuclease III; Provisional; Region: PRK10702 595496004753 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 595496004754 minor groove reading motif; other site 595496004755 helix-hairpin-helix signature motif; other site 595496004756 substrate binding pocket [chemical binding]; other site 595496004757 active site 595496004758 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 595496004759 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 595496004760 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496004761 putative substrate translocation pore; other site 595496004762 POT family; Region: PTR2; pfam00854 595496004763 glutathionine S-transferase; Provisional; Region: PRK10542 595496004764 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 595496004765 C-terminal domain interface [polypeptide binding]; other site 595496004766 GSH binding site (G-site) [chemical binding]; other site 595496004767 dimer interface [polypeptide binding]; other site 595496004768 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 595496004769 N-terminal domain interface [polypeptide binding]; other site 595496004770 dimer interface [polypeptide binding]; other site 595496004771 substrate binding pocket (H-site) [chemical binding]; other site 595496004772 pyridoxamine kinase; Validated; Region: PRK05756 595496004773 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 595496004774 dimer interface [polypeptide binding]; other site 595496004775 pyridoxal binding site [chemical binding]; other site 595496004776 ATP binding site [chemical binding]; other site 595496004777 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 595496004778 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 595496004779 active site 595496004780 HIGH motif; other site 595496004781 dimer interface [polypeptide binding]; other site 595496004782 KMSKS motif; other site 595496004783 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 595496004784 RNA binding surface [nucleotide binding]; other site 595496004785 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 595496004786 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 595496004787 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 595496004788 lysozyme inhibitor; Provisional; Region: PRK11372 595496004789 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 595496004790 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 595496004791 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 595496004792 transcriptional regulator SlyA; Provisional; Region: PRK03573 595496004793 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 595496004794 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 595496004795 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 595496004796 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 595496004797 HlyD family secretion protein; Region: HlyD_3; pfam13437 595496004798 Fusaric acid resistance protein family; Region: FUSC; pfam04632 595496004799 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 595496004800 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 595496004801 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 595496004802 E-class dimer interface [polypeptide binding]; other site 595496004803 P-class dimer interface [polypeptide binding]; other site 595496004804 active site 595496004805 Cu2+ binding site [ion binding]; other site 595496004806 Zn2+ binding site [ion binding]; other site 595496004807 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 595496004808 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 595496004809 active site 595496004810 catalytic tetrad [active] 595496004811 Predicted Fe-S protein [General function prediction only]; Region: COG3313 595496004812 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 595496004813 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 595496004814 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 595496004815 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 595496004816 FMN binding site [chemical binding]; other site 595496004817 active site 595496004818 substrate binding site [chemical binding]; other site 595496004819 catalytic residue [active] 595496004820 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 595496004821 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 595496004822 dimer interface [polypeptide binding]; other site 595496004823 active site 595496004824 metal binding site [ion binding]; metal-binding site 595496004825 glutathione binding site [chemical binding]; other site 595496004826 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 595496004827 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 595496004828 dimer interface [polypeptide binding]; other site 595496004829 catalytic site [active] 595496004830 putative active site [active] 595496004831 putative substrate binding site [chemical binding]; other site 595496004832 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 595496004833 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 595496004834 ATP binding site [chemical binding]; other site 595496004835 putative Mg++ binding site [ion binding]; other site 595496004836 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 595496004837 nucleotide binding region [chemical binding]; other site 595496004838 ATP-binding site [chemical binding]; other site 595496004839 DEAD/H associated; Region: DEAD_assoc; pfam08494 595496004840 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 595496004841 putative GSH binding site [chemical binding]; other site 595496004842 catalytic residues [active] 595496004843 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 595496004844 NlpC/P60 family; Region: NLPC_P60; pfam00877 595496004845 superoxide dismutase; Provisional; Region: PRK10543 595496004846 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 595496004847 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 595496004848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496004849 Major Facilitator Superfamily; Region: MFS_1; pfam07690 595496004850 putative substrate translocation pore; other site 595496004851 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 595496004852 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 595496004853 DNA binding site [nucleotide binding] 595496004854 domain linker motif; other site 595496004855 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 595496004856 dimerization interface [polypeptide binding]; other site 595496004857 ligand binding site [chemical binding]; other site 595496004858 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 595496004859 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496004860 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 595496004861 dimerization interface [polypeptide binding]; other site 595496004862 putative transporter; Provisional; Region: PRK11043 595496004863 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496004864 putative substrate translocation pore; other site 595496004865 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 595496004866 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 595496004867 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 595496004868 S-adenosylmethionine binding site [chemical binding]; other site 595496004869 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 595496004870 Lumazine binding domain; Region: Lum_binding; pfam00677 595496004871 Lumazine binding domain; Region: Lum_binding; pfam00677 595496004872 multidrug efflux protein; Reviewed; Region: PRK01766 595496004873 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 595496004874 cation binding site [ion binding]; other site 595496004875 hypothetical protein; Provisional; Region: PRK09945 595496004876 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 595496004877 putative monooxygenase; Provisional; Region: PRK11118 595496004878 hypothetical protein; Provisional; Region: PRK09897 595496004879 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 595496004880 hypothetical protein; Provisional; Region: PRK09946 595496004881 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 595496004882 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 595496004883 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 595496004884 hypothetical protein; Provisional; Region: PRK09947 595496004885 putative oxidoreductase; Provisional; Region: PRK09849 595496004886 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 595496004887 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 595496004888 hypothetical protein; Provisional; Region: PRK09898 595496004889 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 595496004890 hypothetical protein; Provisional; Region: PRK10292 595496004891 pyruvate kinase; Provisional; Region: PRK09206 595496004892 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 595496004893 domain interfaces; other site 595496004894 active site 595496004895 murein lipoprotein; Provisional; Region: PRK15396 595496004896 L,D-transpeptidase; Provisional; Region: PRK10190 595496004897 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 595496004898 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 595496004899 cysteine desufuration protein SufE; Provisional; Region: PRK09296 595496004900 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 595496004901 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 595496004902 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 595496004903 catalytic residue [active] 595496004904 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 595496004905 FeS assembly protein SufD; Region: sufD; TIGR01981 595496004906 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 595496004907 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 595496004908 Walker A/P-loop; other site 595496004909 ATP binding site [chemical binding]; other site 595496004910 Q-loop/lid; other site 595496004911 ABC transporter signature motif; other site 595496004912 Walker B; other site 595496004913 D-loop; other site 595496004914 H-loop/switch region; other site 595496004915 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 595496004916 putative ABC transporter; Region: ycf24; CHL00085 595496004917 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 595496004918 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 595496004919 CoenzymeA binding site [chemical binding]; other site 595496004920 subunit interaction site [polypeptide binding]; other site 595496004921 PHB binding site; other site 595496004922 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 595496004923 FAD binding domain; Region: FAD_binding_4; pfam01565 595496004924 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 595496004925 putative inner membrane protein; Provisional; Region: PRK10983 595496004926 Domain of unknown function DUF20; Region: UPF0118; pfam01594 595496004927 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 595496004928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496004929 Major Facilitator Superfamily; Region: MFS_1; pfam07690 595496004930 putative substrate translocation pore; other site 595496004931 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496004932 putative substrate translocation pore; other site 595496004933 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 595496004934 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 595496004935 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 595496004936 shikimate binding site; other site 595496004937 NAD(P) binding site [chemical binding]; other site 595496004938 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 595496004939 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 595496004940 active site 595496004941 catalytic residue [active] 595496004942 dimer interface [polypeptide binding]; other site 595496004943 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 595496004944 Coenzyme A transferase; Region: CoA_trans; smart00882 595496004945 Coenzyme A transferase; Region: CoA_trans; cl17247 595496004946 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 595496004947 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 595496004948 active site 595496004949 Cupin domain; Region: Cupin_2; pfam07883 595496004950 Winged helix DNA-binding domain (DUF1495); Region: DUF1495; cl01336 595496004951 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 595496004952 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 595496004953 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 595496004954 Ligand binding site [chemical binding]; other site 595496004955 Electron transfer flavoprotein domain; Region: ETF; pfam01012 595496004956 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 595496004957 Electron transfer flavoprotein domain; Region: ETF; smart00893 595496004958 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 595496004959 oxidoreductase; Provisional; Region: PRK10015 595496004960 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 595496004961 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 595496004962 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 595496004963 acyl-activating enzyme (AAE) consensus motif; other site 595496004964 putative AMP binding site [chemical binding]; other site 595496004965 putative active site [active] 595496004966 putative CoA binding site [chemical binding]; other site 595496004967 phosphoenolpyruvate synthase; Validated; Region: PRK06464 595496004968 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 595496004969 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 595496004970 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 595496004971 PEP synthetase regulatory protein; Provisional; Region: PRK05339 595496004972 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 595496004973 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 595496004974 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 595496004975 Uncharacterized conserved protein [Function unknown]; Region: COG0397 595496004976 hypothetical protein; Validated; Region: PRK00029 595496004977 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 595496004978 NlpC/P60 family; Region: NLPC_P60; pfam00877 595496004979 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 595496004980 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 595496004981 Walker A/P-loop; other site 595496004982 ATP binding site [chemical binding]; other site 595496004983 Q-loop/lid; other site 595496004984 ABC transporter signature motif; other site 595496004985 Walker B; other site 595496004986 D-loop; other site 595496004987 H-loop/switch region; other site 595496004988 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 595496004989 catalytic residues [active] 595496004990 dimer interface [polypeptide binding]; other site 595496004991 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 595496004992 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 595496004993 ABC-ATPase subunit interface; other site 595496004994 dimer interface [polypeptide binding]; other site 595496004995 putative PBP binding regions; other site 595496004996 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 595496004997 IHF dimer interface [polypeptide binding]; other site 595496004998 IHF - DNA interface [nucleotide binding]; other site 595496004999 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 595496005000 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 595496005001 putative tRNA-binding site [nucleotide binding]; other site 595496005002 B3/4 domain; Region: B3_4; pfam03483 595496005003 tRNA synthetase B5 domain; Region: B5; smart00874 595496005004 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 595496005005 dimer interface [polypeptide binding]; other site 595496005006 motif 1; other site 595496005007 motif 3; other site 595496005008 motif 2; other site 595496005009 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 595496005010 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 595496005011 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 595496005012 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 595496005013 dimer interface [polypeptide binding]; other site 595496005014 motif 1; other site 595496005015 active site 595496005016 motif 2; other site 595496005017 motif 3; other site 595496005018 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 595496005019 23S rRNA binding site [nucleotide binding]; other site 595496005020 L21 binding site [polypeptide binding]; other site 595496005021 L13 binding site [polypeptide binding]; other site 595496005022 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 595496005023 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 595496005024 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 595496005025 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 595496005026 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 595496005027 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 595496005028 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 595496005029 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 595496005030 active site 595496005031 dimer interface [polypeptide binding]; other site 595496005032 motif 1; other site 595496005033 motif 2; other site 595496005034 motif 3; other site 595496005035 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 595496005036 anticodon binding site; other site 595496005037 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 595496005038 6-phosphofructokinase 2; Provisional; Region: PRK10294 595496005039 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 595496005040 putative substrate binding site [chemical binding]; other site 595496005041 putative ATP binding site [chemical binding]; other site 595496005042 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 595496005043 Phosphotransferase enzyme family; Region: APH; pfam01636 595496005044 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 595496005045 active site 595496005046 ATP binding site [chemical binding]; other site 595496005047 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 595496005048 YniB-like protein; Region: YniB; pfam14002 595496005049 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 595496005050 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 595496005051 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 595496005052 motif II; other site 595496005053 inner membrane protein; Provisional; Region: PRK11648 595496005054 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 595496005055 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 595496005056 cell division modulator; Provisional; Region: PRK10113 595496005057 hydroperoxidase II; Provisional; Region: katE; PRK11249 595496005058 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 595496005059 tetramer interface [polypeptide binding]; other site 595496005060 heme binding pocket [chemical binding]; other site 595496005061 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 595496005062 domain interactions; other site 595496005063 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 595496005064 putative active site [active] 595496005065 YdjC motif; other site 595496005066 Mg binding site [ion binding]; other site 595496005067 putative homodimer interface [polypeptide binding]; other site 595496005068 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 595496005069 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 595496005070 NAD binding site [chemical binding]; other site 595496005071 sugar binding site [chemical binding]; other site 595496005072 divalent metal binding site [ion binding]; other site 595496005073 tetramer (dimer of dimers) interface [polypeptide binding]; other site 595496005074 dimer interface [polypeptide binding]; other site 595496005075 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 595496005076 Cupin domain; Region: Cupin_2; pfam07883 595496005077 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 595496005078 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 595496005079 methionine cluster; other site 595496005080 active site 595496005081 phosphorylation site [posttranslational modification] 595496005082 metal binding site [ion binding]; metal-binding site 595496005083 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 595496005084 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 595496005085 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 595496005086 active site 595496005087 P-loop; other site 595496005088 phosphorylation site [posttranslational modification] 595496005089 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 595496005090 NAD+ synthetase; Region: nadE; TIGR00552 595496005091 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 595496005092 homodimer interface [polypeptide binding]; other site 595496005093 NAD binding pocket [chemical binding]; other site 595496005094 ATP binding pocket [chemical binding]; other site 595496005095 Mg binding site [ion binding]; other site 595496005096 active-site loop [active] 595496005097 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 595496005098 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 595496005099 GIY-YIG motif/motif A; other site 595496005100 active site 595496005101 catalytic site [active] 595496005102 putative DNA binding site [nucleotide binding]; other site 595496005103 metal binding site [ion binding]; metal-binding site 595496005104 hypothetical protein; Provisional; Region: PRK11396 595496005105 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 595496005106 dimer interface [polypeptide binding]; other site 595496005107 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 595496005108 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 595496005109 putative active site [active] 595496005110 Zn binding site [ion binding]; other site 595496005111 succinylarginine dihydrolase; Provisional; Region: PRK13281 595496005112 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 595496005113 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 595496005114 NAD(P) binding site [chemical binding]; other site 595496005115 catalytic residues [active] 595496005116 arginine succinyltransferase; Provisional; Region: PRK10456 595496005117 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 595496005118 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 595496005119 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 595496005120 inhibitor-cofactor binding pocket; inhibition site 595496005121 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496005122 catalytic residue [active] 595496005123 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 595496005124 putative catalytic site [active] 595496005125 putative phosphate binding site [ion binding]; other site 595496005126 active site 595496005127 metal binding site A [ion binding]; metal-binding site 595496005128 DNA binding site [nucleotide binding] 595496005129 putative AP binding site [nucleotide binding]; other site 595496005130 putative metal binding site B [ion binding]; other site 595496005131 Uncharacterized conserved protein [Function unknown]; Region: COG0398 595496005132 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 595496005133 Uncharacterized conserved protein [Function unknown]; Region: COG0398 595496005134 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 595496005135 Uncharacterized conserved protein [Function unknown]; Region: COG2128 595496005136 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 595496005137 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 595496005138 hypothetical protein; Provisional; Region: PRK11622 595496005139 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 595496005140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496005141 dimer interface [polypeptide binding]; other site 595496005142 conserved gate region; other site 595496005143 putative PBP binding loops; other site 595496005144 ABC-ATPase subunit interface; other site 595496005145 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 595496005146 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 595496005147 Walker A/P-loop; other site 595496005148 ATP binding site [chemical binding]; other site 595496005149 Q-loop/lid; other site 595496005150 ABC transporter signature motif; other site 595496005151 Walker B; other site 595496005152 D-loop; other site 595496005153 H-loop/switch region; other site 595496005154 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 595496005155 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 595496005156 active site residue [active] 595496005157 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 595496005158 active site residue [active] 595496005159 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 595496005160 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 595496005161 active site 595496005162 8-oxo-dGMP binding site [chemical binding]; other site 595496005163 nudix motif; other site 595496005164 metal binding site [ion binding]; metal-binding site 595496005165 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 595496005166 glutamate dehydrogenase; Provisional; Region: PRK09414 595496005167 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 595496005168 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 595496005169 NAD(P) binding site [chemical binding]; other site 595496005170 hypothetical protein; Provisional; Region: PRK11380 595496005171 DNA topoisomerase III; Provisional; Region: PRK07726 595496005172 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 595496005173 active site 595496005174 putative interdomain interaction site [polypeptide binding]; other site 595496005175 putative metal-binding site [ion binding]; other site 595496005176 putative nucleotide binding site [chemical binding]; other site 595496005177 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 595496005178 domain I; other site 595496005179 DNA binding groove [nucleotide binding] 595496005180 phosphate binding site [ion binding]; other site 595496005181 domain II; other site 595496005182 domain III; other site 595496005183 nucleotide binding site [chemical binding]; other site 595496005184 catalytic site [active] 595496005185 domain IV; other site 595496005186 selenophosphate synthetase; Provisional; Region: PRK00943 595496005187 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 595496005188 dimerization interface [polypeptide binding]; other site 595496005189 putative ATP binding site [chemical binding]; other site 595496005190 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 595496005191 putative FMN binding site [chemical binding]; other site 595496005192 protease 4; Provisional; Region: PRK10949 595496005193 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 595496005194 tandem repeat interface [polypeptide binding]; other site 595496005195 oligomer interface [polypeptide binding]; other site 595496005196 active site residues [active] 595496005197 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 595496005198 tandem repeat interface [polypeptide binding]; other site 595496005199 oligomer interface [polypeptide binding]; other site 595496005200 active site residues [active] 595496005201 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 595496005202 active site 595496005203 homodimer interface [polypeptide binding]; other site 595496005204 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 595496005205 Isochorismatase family; Region: Isochorismatase; pfam00857 595496005206 catalytic triad [active] 595496005207 metal binding site [ion binding]; metal-binding site 595496005208 conserved cis-peptide bond; other site 595496005209 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 595496005210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496005211 putative substrate translocation pore; other site 595496005212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496005213 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 595496005214 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 595496005215 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 595496005216 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 595496005217 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 595496005218 active site 595496005219 catalytic tetrad [active] 595496005220 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 595496005221 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 595496005222 substrate binding site [chemical binding]; other site 595496005223 ATP binding site [chemical binding]; other site 595496005224 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 595496005225 intersubunit interface [polypeptide binding]; other site 595496005226 active site 595496005227 zinc binding site [ion binding]; other site 595496005228 Na+ binding site [ion binding]; other site 595496005229 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 595496005230 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 595496005231 inhibitor binding site; inhibition site 595496005232 catalytic Zn binding site [ion binding]; other site 595496005233 structural Zn binding site [ion binding]; other site 595496005234 NADP binding site [chemical binding]; other site 595496005235 tetramer interface [polypeptide binding]; other site 595496005236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496005237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496005238 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 595496005239 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 595496005240 putative NAD(P) binding site [chemical binding]; other site 595496005241 catalytic Zn binding site [ion binding]; other site 595496005242 structural Zn binding site [ion binding]; other site 595496005243 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 595496005244 methionine sulfoxide reductase B; Provisional; Region: PRK00222 595496005245 SelR domain; Region: SelR; pfam01641 595496005246 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 595496005247 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 595496005248 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 595496005249 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 595496005250 active site 595496005251 phosphate binding residues; other site 595496005252 catalytic residues [active] 595496005253 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 595496005254 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 595496005255 active site 595496005256 catalytic tetrad [active] 595496005257 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 595496005258 PrkA family serine protein kinase; Provisional; Region: PRK15455 595496005259 AAA ATPase domain; Region: AAA_16; pfam13191 595496005260 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 595496005261 hypothetical protein; Provisional; Region: PRK05325 595496005262 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 595496005263 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 595496005264 metal binding site [ion binding]; metal-binding site 595496005265 active site 595496005266 I-site; other site 595496005267 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 595496005268 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 595496005269 metal binding site [ion binding]; metal-binding site 595496005270 active site 595496005271 I-site; other site 595496005272 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 595496005273 putative deacylase active site [active] 595496005274 Predicted membrane protein [Function unknown]; Region: COG2707 595496005275 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 595496005276 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 595496005277 cyanate transporter; Region: CynX; TIGR00896 595496005278 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496005279 Uncharacterized conserved protein [Function unknown]; Region: COG3189 595496005280 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 595496005281 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 595496005282 Domain of unknown function (DUF333); Region: DUF333; pfam03891 595496005283 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 595496005284 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 595496005285 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 595496005286 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 595496005287 metal binding site [ion binding]; metal-binding site 595496005288 active site 595496005289 I-site; other site 595496005290 hypothetical protein; Provisional; Region: PRK10457 595496005291 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 595496005292 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 595496005293 leucine export protein LeuE; Provisional; Region: PRK10958 595496005294 transcriptional activator TtdR; Provisional; Region: PRK09801 595496005295 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496005296 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 595496005297 putative effector binding pocket; other site 595496005298 putative dimerization interface [polypeptide binding]; other site 595496005299 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 595496005300 tartrate dehydrogenase; Region: TTC; TIGR02089 595496005301 putative transporter; Provisional; Region: PRK09950 595496005302 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 595496005303 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 595496005304 [2Fe-2S] cluster binding site [ion binding]; other site 595496005305 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886 595496005306 putative alpha subunit interface [polypeptide binding]; other site 595496005307 putative active site [active] 595496005308 putative substrate binding site [chemical binding]; other site 595496005309 Fe binding site [ion binding]; other site 595496005310 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 595496005311 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 595496005312 FMN-binding pocket [chemical binding]; other site 595496005313 flavin binding motif; other site 595496005314 phosphate binding motif [ion binding]; other site 595496005315 beta-alpha-beta structure motif; other site 595496005316 NAD binding pocket [chemical binding]; other site 595496005317 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 595496005318 catalytic loop [active] 595496005319 iron binding site [ion binding]; other site 595496005320 ribonuclease D; Provisional; Region: PRK10829 595496005321 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 595496005322 catalytic site [active] 595496005323 putative active site [active] 595496005324 putative substrate binding site [chemical binding]; other site 595496005325 Helicase and RNase D C-terminal; Region: HRDC; smart00341 595496005326 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 595496005327 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 595496005328 acyl-activating enzyme (AAE) consensus motif; other site 595496005329 putative AMP binding site [chemical binding]; other site 595496005330 putative active site [active] 595496005331 putative CoA binding site [chemical binding]; other site 595496005332 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 595496005333 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 595496005334 Glycoprotease family; Region: Peptidase_M22; pfam00814 595496005335 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 595496005336 DEAD/DEAH box helicase; Region: DEAD; pfam00270 595496005337 DEAD_2; Region: DEAD_2; pfam06733 595496005338 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 595496005339 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 595496005340 homotrimer interaction site [polypeptide binding]; other site 595496005341 putative active site [active] 595496005342 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 595496005343 hypothetical protein; Provisional; Region: PRK05114 595496005344 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 595496005345 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 595496005346 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 595496005347 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 595496005348 putative active site [active] 595496005349 putative CoA binding site [chemical binding]; other site 595496005350 nudix motif; other site 595496005351 metal binding site [ion binding]; metal-binding site 595496005352 L-serine deaminase; Provisional; Region: PRK15023 595496005353 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 595496005354 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 595496005355 phage resistance protein; Provisional; Region: PRK10551 595496005356 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 595496005357 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 595496005358 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 595496005359 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 595496005360 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 595496005361 Transporter associated domain; Region: CorC_HlyC; smart01091 595496005362 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 595496005363 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 595496005364 active pocket/dimerization site; other site 595496005365 active site 595496005366 phosphorylation site [posttranslational modification] 595496005367 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 595496005368 active site 595496005369 phosphorylation site [posttranslational modification] 595496005370 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 595496005371 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 595496005372 Predicted membrane protein [Function unknown]; Region: COG4811 595496005373 hypothetical protein; Provisional; Region: PRK11469 595496005374 Domain of unknown function DUF; Region: DUF204; pfam02659 595496005375 Domain of unknown function DUF; Region: DUF204; pfam02659 595496005376 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 595496005377 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 595496005378 S-adenosylmethionine binding site [chemical binding]; other site 595496005379 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 595496005380 DNA-binding site [nucleotide binding]; DNA binding site 595496005381 RNA-binding motif; other site 595496005382 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 595496005383 YebO-like protein; Region: YebO; pfam13974 595496005384 PhoPQ regulatory protein; Provisional; Region: PRK10299 595496005385 YobH-like protein; Region: YobH; pfam13996 595496005386 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 595496005387 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 595496005388 dimerization interface [polypeptide binding]; other site 595496005389 putative Zn2+ binding site [ion binding]; other site 595496005390 putative DNA binding site [nucleotide binding]; other site 595496005391 Bacterial transcriptional regulator; Region: IclR; pfam01614 595496005392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496005393 Major Facilitator Superfamily; Region: MFS_1; pfam07690 595496005394 putative substrate translocation pore; other site 595496005395 Predicted integral membrane protein [Function unknown]; Region: COG5521 595496005396 heat shock protein HtpX; Provisional; Region: PRK05457 595496005397 carboxy-terminal protease; Provisional; Region: PRK11186 595496005398 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 595496005399 protein binding site [polypeptide binding]; other site 595496005400 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 595496005401 Catalytic dyad [active] 595496005402 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 595496005403 ProP expression regulator; Provisional; Region: PRK04950 595496005404 ProQ/FINO family; Region: ProQ; pfam04352 595496005405 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 595496005406 GAF domain; Region: GAF_2; pfam13185 595496005407 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 595496005408 Paraquat-inducible protein A; Region: PqiA; pfam04403 595496005409 Paraquat-inducible protein A; Region: PqiA; pfam04403 595496005410 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 595496005411 mce related protein; Region: MCE; pfam02470 595496005412 mce related protein; Region: MCE; pfam02470 595496005413 mce related protein; Region: MCE; pfam02470 595496005414 mce related protein; Region: MCE; pfam02470 595496005415 mce related protein; Region: MCE; pfam02470 595496005416 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 595496005417 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 595496005418 S-adenosylmethionine binding site [chemical binding]; other site 595496005419 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 595496005420 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 595496005421 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 595496005422 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 595496005423 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 595496005424 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 595496005425 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 595496005426 hypothetical protein; Provisional; Region: PRK10301 595496005427 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 595496005428 Predicted amidohydrolase [General function prediction only]; Region: COG0388 595496005429 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 595496005430 exodeoxyribonuclease X; Provisional; Region: PRK07983 595496005431 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 595496005432 active site 595496005433 catalytic site [active] 595496005434 substrate binding site [chemical binding]; other site 595496005435 protease 2; Provisional; Region: PRK10115 595496005436 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 595496005437 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 595496005438 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 595496005439 putative metal binding site [ion binding]; other site 595496005440 hypothetical protein; Provisional; Region: PRK13680 595496005441 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 595496005442 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 595496005443 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 595496005444 ATP-grasp domain; Region: ATP-grasp; pfam02222 595496005445 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 595496005446 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 595496005447 active site 595496005448 intersubunit interface [polypeptide binding]; other site 595496005449 catalytic residue [active] 595496005450 phosphogluconate dehydratase; Validated; Region: PRK09054 595496005451 6-phosphogluconate dehydratase; Region: edd; TIGR01196 595496005452 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 595496005453 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 595496005454 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 595496005455 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 595496005456 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 595496005457 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 595496005458 putative active site [active] 595496005459 pyruvate kinase; Provisional; Region: PRK05826 595496005460 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 595496005461 domain interfaces; other site 595496005462 active site 595496005463 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 595496005464 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 595496005465 putative acyl-acceptor binding pocket; other site 595496005466 putative peptidase; Provisional; Region: PRK11649 595496005467 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 595496005468 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 595496005469 Peptidase family M23; Region: Peptidase_M23; pfam01551 595496005470 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 595496005471 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 595496005472 metal binding site [ion binding]; metal-binding site 595496005473 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 595496005474 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 595496005475 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 595496005476 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 595496005477 ABC-ATPase subunit interface; other site 595496005478 dimer interface [polypeptide binding]; other site 595496005479 putative PBP binding regions; other site 595496005480 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 595496005481 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 595496005482 Walker A motif; other site 595496005483 ATP binding site [chemical binding]; other site 595496005484 Walker B motif; other site 595496005485 arginine finger; other site 595496005486 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 595496005487 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 595496005488 RuvA N terminal domain; Region: RuvA_N; pfam01330 595496005489 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 595496005490 hypothetical protein; Provisional; Region: PRK11470 595496005491 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 595496005492 active site 595496005493 putative DNA-binding cleft [nucleotide binding]; other site 595496005494 dimer interface [polypeptide binding]; other site 595496005495 hypothetical protein; Validated; Region: PRK00110 595496005496 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 595496005497 nudix motif; other site 595496005498 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 595496005499 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 595496005500 dimer interface [polypeptide binding]; other site 595496005501 anticodon binding site; other site 595496005502 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 595496005503 homodimer interface [polypeptide binding]; other site 595496005504 motif 1; other site 595496005505 active site 595496005506 motif 2; other site 595496005507 GAD domain; Region: GAD; pfam02938 595496005508 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 595496005509 motif 3; other site 595496005510 Isochorismatase family; Region: Isochorismatase; pfam00857 595496005511 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 595496005512 catalytic triad [active] 595496005513 conserved cis-peptide bond; other site 595496005514 hypothetical protein; Provisional; Region: PRK10302 595496005515 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 595496005516 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 595496005517 S-adenosylmethionine binding site [chemical binding]; other site 595496005518 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 595496005519 S-adenosylmethionine binding site [chemical binding]; other site 595496005520 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 595496005521 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 595496005522 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 595496005523 molybdopterin cofactor binding site [chemical binding]; other site 595496005524 substrate binding site [chemical binding]; other site 595496005525 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 595496005526 molybdopterin cofactor binding site; other site 595496005527 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 595496005528 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 595496005529 copper homeostasis protein CutC; Provisional; Region: PRK11572 595496005530 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 595496005531 putative metal binding site [ion binding]; other site 595496005532 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 595496005533 arginyl-tRNA synthetase; Region: argS; TIGR00456 595496005534 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 595496005535 active site 595496005536 HIGH motif; other site 595496005537 KMSK motif region; other site 595496005538 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 595496005539 tRNA binding surface [nucleotide binding]; other site 595496005540 anticodon binding site; other site 595496005541 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 595496005542 Flagellar protein FlhE; Region: FlhE; pfam06366 595496005543 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 595496005544 FHIPEP family; Region: FHIPEP; pfam00771 595496005545 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 595496005546 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 595496005547 chemotaxis regulator CheZ; Provisional; Region: PRK11166 595496005548 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 595496005549 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 595496005550 active site 595496005551 phosphorylation site [posttranslational modification] 595496005552 intermolecular recognition site; other site 595496005553 dimerization interface [polypeptide binding]; other site 595496005554 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 595496005555 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 595496005556 active site 595496005557 phosphorylation site [posttranslational modification] 595496005558 intermolecular recognition site; other site 595496005559 dimerization interface [polypeptide binding]; other site 595496005560 CheB methylesterase; Region: CheB_methylest; pfam01339 595496005561 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 595496005562 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 595496005563 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 595496005564 S-adenosylmethionine binding site [chemical binding]; other site 595496005565 methyl-accepting protein IV; Provisional; Region: PRK09793 595496005566 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 595496005567 dimer interface [polypeptide binding]; other site 595496005568 ligand binding site [chemical binding]; other site 595496005569 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 595496005570 dimerization interface [polypeptide binding]; other site 595496005571 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 595496005572 dimer interface [polypeptide binding]; other site 595496005573 putative CheW interface [polypeptide binding]; other site 595496005574 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 595496005575 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 595496005576 dimer interface [polypeptide binding]; other site 595496005577 ligand binding site [chemical binding]; other site 595496005578 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 595496005579 dimerization interface [polypeptide binding]; other site 595496005580 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 595496005581 dimer interface [polypeptide binding]; other site 595496005582 putative CheW interface [polypeptide binding]; other site 595496005583 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 595496005584 putative CheA interaction surface; other site 595496005585 chemotaxis protein CheA; Provisional; Region: PRK10547 595496005586 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 595496005587 putative binding surface; other site 595496005588 active site 595496005589 CheY binding; Region: CheY-binding; pfam09078 595496005590 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 595496005591 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 595496005592 ATP binding site [chemical binding]; other site 595496005593 Mg2+ binding site [ion binding]; other site 595496005594 G-X-G motif; other site 595496005595 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 595496005596 flagellar motor protein MotB; Validated; Region: motB; PRK09041 595496005597 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 595496005598 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 595496005599 ligand binding site [chemical binding]; other site 595496005600 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 595496005601 flagellar motor protein MotA; Validated; Region: PRK09110 595496005602 transcriptional activator FlhC; Provisional; Region: PRK12722 595496005603 Transposase domain (DUF772); Region: DUF772; pfam05598 595496005604 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 595496005605 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 595496005606 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 595496005607 Ligand Binding Site [chemical binding]; other site 595496005608 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 595496005609 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 595496005610 active site 595496005611 homotetramer interface [polypeptide binding]; other site 595496005612 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 595496005613 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 595496005614 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 595496005615 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 595496005616 TM-ABC transporter signature motif; other site 595496005617 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 595496005618 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 595496005619 Walker A/P-loop; other site 595496005620 ATP binding site [chemical binding]; other site 595496005621 Q-loop/lid; other site 595496005622 ABC transporter signature motif; other site 595496005623 Walker B; other site 595496005624 D-loop; other site 595496005625 H-loop/switch region; other site 595496005626 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 595496005627 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 595496005628 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 595496005629 ligand binding site [chemical binding]; other site 595496005630 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 595496005631 Ferritin-like domain; Region: Ferritin; pfam00210 595496005632 ferroxidase diiron center [ion binding]; other site 595496005633 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 595496005634 YecR-like lipoprotein; Region: YecR; pfam13992 595496005635 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 595496005636 Ferritin-like domain; Region: Ferritin; pfam00210 595496005637 ferroxidase diiron center [ion binding]; other site 595496005638 probable metal-binding protein; Region: matur_matur; TIGR03853 595496005639 tyrosine transporter TyrP; Provisional; Region: PRK15132 595496005640 aromatic amino acid transport protein; Region: araaP; TIGR00837 595496005641 hypothetical protein; Provisional; Region: PRK10396 595496005642 yecA family protein; Region: ygfB_yecA; TIGR02292 595496005643 SEC-C motif; Region: SEC-C; pfam02810 595496005644 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 595496005645 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 595496005646 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 595496005647 GIY-YIG motif/motif A; other site 595496005648 active site 595496005649 catalytic site [active] 595496005650 putative DNA binding site [nucleotide binding]; other site 595496005651 metal binding site [ion binding]; metal-binding site 595496005652 UvrB/uvrC motif; Region: UVR; pfam02151 595496005653 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 595496005654 Helix-hairpin-helix motif; Region: HHH; pfam00633 595496005655 response regulator; Provisional; Region: PRK09483 595496005656 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 595496005657 active site 595496005658 phosphorylation site [posttranslational modification] 595496005659 intermolecular recognition site; other site 595496005660 dimerization interface [polypeptide binding]; other site 595496005661 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 595496005662 DNA binding residues [nucleotide binding] 595496005663 dimerization interface [polypeptide binding]; other site 595496005664 hypothetical protein; Provisional; Region: PRK10613 595496005665 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 595496005666 Autoinducer binding domain; Region: Autoind_bind; pfam03472 595496005667 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 595496005668 DNA binding residues [nucleotide binding] 595496005669 dimerization interface [polypeptide binding]; other site 595496005670 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 595496005671 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 595496005672 Walker A/P-loop; other site 595496005673 ATP binding site [chemical binding]; other site 595496005674 Q-loop/lid; other site 595496005675 ABC transporter signature motif; other site 595496005676 Walker B; other site 595496005677 D-loop; other site 595496005678 H-loop/switch region; other site 595496005679 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 595496005680 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496005681 dimer interface [polypeptide binding]; other site 595496005682 conserved gate region; other site 595496005683 putative PBP binding loops; other site 595496005684 ABC-ATPase subunit interface; other site 595496005685 D-cysteine desulfhydrase; Validated; Region: PRK03910 595496005686 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 595496005687 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496005688 catalytic residue [active] 595496005689 cystine transporter subunit; Provisional; Region: PRK11260 595496005690 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 595496005691 substrate binding pocket [chemical binding]; other site 595496005692 membrane-bound complex binding site; other site 595496005693 hinge residues; other site 595496005694 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 595496005695 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 595496005696 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 595496005697 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 595496005698 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 595496005699 DNA binding residues [nucleotide binding] 595496005700 flagellin; Validated; Region: PRK08026 595496005701 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 595496005702 Flagellin D3 domain; Region: Flagellin_D3; pfam08884 595496005703 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 595496005704 flagellar capping protein; Reviewed; Region: fliD; PRK08032 595496005705 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 595496005706 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 595496005707 flagellar biosynthetic protein FliS; Region: fliS; TIGR00208 595496005708 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 595496005709 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 595496005710 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 595496005711 active site 595496005712 Na/Ca binding site [ion binding]; other site 595496005713 catalytic site [active] 595496005714 lipoprotein; Provisional; Region: PRK10397 595496005715 putative inner membrane protein; Provisional; Region: PRK11099 595496005716 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 595496005717 CPxP motif; other site 595496005718 hypothetical protein; Provisional; Region: PRK09951 595496005719 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 595496005720 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 595496005721 Coenzyme A binding pocket [chemical binding]; other site 595496005722 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 595496005723 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 595496005724 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 595496005725 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 595496005726 flagellar motor switch protein FliG; Region: fliG; TIGR00207 595496005727 FliG C-terminal domain; Region: FliG_C; pfam01706 595496005728 flagellar assembly protein H; Validated; Region: fliH; PRK05687 595496005729 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 595496005730 Flagellar assembly protein FliH; Region: FliH; pfam02108 595496005731 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 595496005732 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 595496005733 Walker A motif/ATP binding site; other site 595496005734 Walker B motif; other site 595496005735 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 595496005736 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 595496005737 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 595496005738 flagellar hook-length control protein; Provisional; Region: PRK10118 595496005739 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 595496005740 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 595496005741 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 595496005742 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 595496005743 flagellar motor switch protein; Validated; Region: fliN; PRK05698 595496005744 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 595496005745 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 595496005746 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 595496005747 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 595496005748 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 595496005749 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 595496005750 DNA binding residues [nucleotide binding] 595496005751 dimerization interface [polypeptide binding]; other site 595496005752 hypothetical protein; Provisional; Region: PRK10708 595496005753 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 595496005754 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 595496005755 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 595496005756 active site 595496005757 motif I; other site 595496005758 motif II; other site 595496005759 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 595496005760 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 595496005761 metal binding site [ion binding]; metal-binding site 595496005762 active site 595496005763 I-site; other site 595496005764 Uncharacterized small protein [Function unknown]; Region: COG5475 595496005765 hypothetical protein; Provisional; Region: PRK10062 595496005766 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 595496005767 EamA-like transporter family; Region: EamA; pfam00892 595496005768 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 595496005769 additional DNA contacts [nucleotide binding]; other site 595496005770 mismatch recognition site; other site 595496005771 active site 595496005772 zinc binding site [ion binding]; other site 595496005773 DNA intercalation site [nucleotide binding]; other site 595496005774 DNA cytosine methylase; Provisional; Region: PRK10458 595496005775 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 595496005776 cofactor binding site; other site 595496005777 DNA binding site [nucleotide binding] 595496005778 substrate interaction site [chemical binding]; other site 595496005779 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 595496005780 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 595496005781 Zn2+ binding site [ion binding]; other site 595496005782 Mg2+ binding site [ion binding]; other site 595496005783 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 595496005784 chaperone protein HchA; Provisional; Region: PRK04155 595496005785 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 595496005786 dimer interface [polypeptide binding]; other site 595496005787 metal binding site [ion binding]; metal-binding site 595496005788 potential oxyanion hole; other site 595496005789 potential catalytic triad [active] 595496005790 conserved cys residue [active] 595496005791 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 595496005792 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 595496005793 dimer interface [polypeptide binding]; other site 595496005794 phosphorylation site [posttranslational modification] 595496005795 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 595496005796 ATP binding site [chemical binding]; other site 595496005797 Mg2+ binding site [ion binding]; other site 595496005798 G-X-G motif; other site 595496005799 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 595496005800 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 595496005801 active site 595496005802 phosphorylation site [posttranslational modification] 595496005803 intermolecular recognition site; other site 595496005804 dimerization interface [polypeptide binding]; other site 595496005805 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 595496005806 DNA binding site [nucleotide binding] 595496005807 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 595496005808 active site 595496005809 homotetramer interface [polypeptide binding]; other site 595496005810 TMAO/DMSO reductase; Reviewed; Region: PRK05363 595496005811 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 595496005812 Moco binding site; other site 595496005813 metal coordination site [ion binding]; other site 595496005814 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 595496005815 zinc/cadmium-binding protein; Provisional; Region: PRK10306 595496005816 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 595496005817 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 595496005818 putative invasin; Provisional; Region: PRK10177 595496005819 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 595496005820 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 595496005821 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 595496005822 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 595496005823 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 595496005824 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 595496005825 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 595496005826 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 595496005827 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 595496005828 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 595496005829 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 595496005830 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 595496005831 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 595496005832 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 595496005833 shikimate transporter; Provisional; Region: PRK09952 595496005834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496005835 putative substrate translocation pore; other site 595496005836 AMP nucleosidase; Provisional; Region: PRK08292 595496005837 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 595496005838 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 595496005839 hypothetical protein; Provisional; Region: PRK12378 595496005840 MATE family multidrug exporter; Provisional; Region: PRK10189 595496005841 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 595496005842 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 595496005843 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496005844 The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444 595496005845 putative substrate binding site [chemical binding]; other site 595496005846 dimerization interface [polypeptide binding]; other site 595496005847 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 595496005848 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496005849 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 595496005850 putative dimerization interface [polypeptide binding]; other site 595496005851 L,D-transpeptidase; Provisional; Region: PRK10190 595496005852 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 595496005853 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 595496005854 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 595496005855 putative dimer interface [polypeptide binding]; other site 595496005856 active site pocket [active] 595496005857 putative cataytic base [active] 595496005858 cobalamin 5'-phosphate synthase/cobalamin synthase; Region: cobS; TIGR00317 595496005859 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 595496005860 homotrimer interface [polypeptide binding]; other site 595496005861 Walker A motif; other site 595496005862 GTP binding site [chemical binding]; other site 595496005863 Walker B motif; other site 595496005864 Transposase domain (DUF772); Region: DUF772; pfam05598 595496005865 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 595496005866 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 595496005867 IS2 transposase TnpB; Reviewed; Region: PRK09409 595496005868 HTH-like domain; Region: HTH_21; pfam13276 595496005869 Integrase core domain; Region: rve; pfam00665 595496005870 Integrase core domain; Region: rve_3; pfam13683 595496005871 IS2 repressor TnpA; Reviewed; Region: PRK09413 595496005872 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 595496005873 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 595496005874 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 595496005875 hypothetical protein; Provisional; Region: PRK09945 595496005876 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 595496005877 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 595496005878 Autotransporter beta-domain; Region: Autotransporter; smart00869 595496005879 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 595496005880 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 595496005881 MPN+ (JAMM) motif; other site 595496005882 Zinc-binding site [ion binding]; other site 595496005883 Protein of unknown function (DUF987); Region: DUF987; pfam06174 595496005884 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 595496005885 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 595496005886 hypothetical protein; Provisional; Region: PRK05423 595496005887 Predicted membrane protein [Function unknown]; Region: COG1289 595496005888 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 595496005889 DNA gyrase inhibitor; Provisional; Region: PRK10016 595496005890 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 595496005891 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 595496005892 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 595496005893 exonuclease I; Provisional; Region: sbcB; PRK11779 595496005894 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 595496005895 active site 595496005896 catalytic site [active] 595496005897 substrate binding site [chemical binding]; other site 595496005898 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 595496005899 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 595496005900 CPxP motif; other site 595496005901 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 595496005902 Sulphur transport; Region: Sulf_transp; pfam04143 595496005903 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 595496005904 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496005905 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 595496005906 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 595496005907 dimerization interface [polypeptide binding]; other site 595496005908 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 595496005909 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 595496005910 putative NAD(P) binding site [chemical binding]; other site 595496005911 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 595496005912 antitoxin YefM; Provisional; Region: PRK11409 595496005913 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 595496005914 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 595496005915 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 595496005916 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 595496005917 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 595496005918 NAD binding site [chemical binding]; other site 595496005919 dimerization interface [polypeptide binding]; other site 595496005920 product binding site; other site 595496005921 substrate binding site [chemical binding]; other site 595496005922 zinc binding site [ion binding]; other site 595496005923 catalytic residues [active] 595496005924 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 595496005925 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 595496005926 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496005927 homodimer interface [polypeptide binding]; other site 595496005928 catalytic residue [active] 595496005929 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 595496005930 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 595496005931 active site 595496005932 motif I; other site 595496005933 motif II; other site 595496005934 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 595496005935 putative active site pocket [active] 595496005936 4-fold oligomerization interface [polypeptide binding]; other site 595496005937 metal binding residues [ion binding]; metal-binding site 595496005938 3-fold/trimer interface [polypeptide binding]; other site 595496005939 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 595496005940 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 595496005941 putative active site [active] 595496005942 oxyanion strand; other site 595496005943 catalytic triad [active] 595496005944 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 595496005945 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 595496005946 catalytic residues [active] 595496005947 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 595496005948 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 595496005949 substrate binding site [chemical binding]; other site 595496005950 glutamase interaction surface [polypeptide binding]; other site 595496005951 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 595496005952 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 595496005953 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 595496005954 metal binding site [ion binding]; metal-binding site 595496005955 chain length determinant protein WzzB; Provisional; Region: PRK15471 595496005956 Chain length determinant protein; Region: Wzz; pfam02706 595496005957 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 595496005958 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 595496005959 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 595496005960 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 595496005961 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 595496005962 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 595496005963 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 595496005964 Transposase domain (DUF772); Region: DUF772; pfam05598 595496005965 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 595496005966 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 595496005967 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 595496005968 Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534 595496005969 putative lipopolysaccharide biosynthesis O-acetyl transferase WbbJ; Provisional; Region: PRK09677 595496005970 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 595496005971 trimer interface [polypeptide binding]; other site 595496005972 active site 595496005973 substrate binding site [chemical binding]; other site 595496005974 CoA binding site [chemical binding]; other site 595496005975 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 595496005976 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 595496005977 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 595496005978 UDP-galactopyranose mutase; Region: GLF; pfam03275 595496005979 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 595496005980 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 595496005981 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 595496005982 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 595496005983 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 595496005984 substrate binding site; other site 595496005985 tetramer interface; other site 595496005986 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 595496005987 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 595496005988 NADP binding site [chemical binding]; other site 595496005989 active site 595496005990 putative substrate binding site [chemical binding]; other site 595496005991 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 595496005992 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 595496005993 NAD binding site [chemical binding]; other site 595496005994 substrate binding site [chemical binding]; other site 595496005995 homodimer interface [polypeptide binding]; other site 595496005996 active site 595496005997 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 595496005998 active site 595496005999 tetramer interface; other site 595496006000 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 595496006001 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 595496006002 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 595496006003 putative ADP-binding pocket [chemical binding]; other site 595496006004 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 595496006005 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 595496006006 colanic acid exporter; Provisional; Region: PRK10459 595496006007 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 595496006008 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 595496006009 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 595496006010 phosphomannomutase CpsG; Provisional; Region: PRK15414 595496006011 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 595496006012 active site 595496006013 substrate binding site [chemical binding]; other site 595496006014 metal binding site [ion binding]; metal-binding site 595496006015 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 595496006016 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 595496006017 Substrate binding site; other site 595496006018 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 595496006019 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 595496006020 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 595496006021 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 595496006022 active site 595496006023 GDP-Mannose binding site [chemical binding]; other site 595496006024 dimer interface [polypeptide binding]; other site 595496006025 modified nudix motif 595496006026 metal binding site [ion binding]; metal-binding site 595496006027 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 595496006028 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 595496006029 NADP binding site [chemical binding]; other site 595496006030 active site 595496006031 putative substrate binding site [chemical binding]; other site 595496006032 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 595496006033 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 595496006034 NADP-binding site; other site 595496006035 homotetramer interface [polypeptide binding]; other site 595496006036 substrate binding site [chemical binding]; other site 595496006037 homodimer interface [polypeptide binding]; other site 595496006038 active site 595496006039 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 595496006040 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 595496006041 putative trimer interface [polypeptide binding]; other site 595496006042 putative active site [active] 595496006043 putative substrate binding site [chemical binding]; other site 595496006044 putative CoA binding site [chemical binding]; other site 595496006045 putative glycosyl transferase; Provisional; Region: PRK10063 595496006046 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 595496006047 metal-binding site 595496006048 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 595496006049 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 595496006050 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 595496006051 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 595496006052 putative acyl transferase; Provisional; Region: PRK10191 595496006053 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 595496006054 trimer interface [polypeptide binding]; other site 595496006055 active site 595496006056 substrate binding site [chemical binding]; other site 595496006057 CoA binding site [chemical binding]; other site 595496006058 putative glycosyl transferase; Provisional; Region: PRK10018 595496006059 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 595496006060 active site 595496006061 tyrosine kinase; Provisional; Region: PRK11519 595496006062 Chain length determinant protein; Region: Wzz; pfam02706 595496006063 Chain length determinant protein; Region: Wzz; cl15801 595496006064 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 595496006065 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 595496006066 Low molecular weight phosphatase family; Region: LMWPc; cd00115 595496006067 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 595496006068 active site 595496006069 polysaccharide export protein Wza; Provisional; Region: PRK15078 595496006070 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 595496006071 SLBB domain; Region: SLBB; pfam10531 595496006072 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 595496006073 FOG: CBS domain [General function prediction only]; Region: COG0517 595496006074 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 595496006075 Transporter associated domain; Region: CorC_HlyC; smart01091 595496006076 putative assembly protein; Provisional; Region: PRK10833 595496006077 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 595496006078 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 595496006079 trimer interface [polypeptide binding]; other site 595496006080 active site 595496006081 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 595496006082 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 595496006083 ATP-binding site [chemical binding]; other site 595496006084 Sugar specificity; other site 595496006085 Pyrimidine base specificity; other site 595496006086 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 595496006087 putative diguanylate cyclase; Provisional; Region: PRK09776 595496006088 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 595496006089 putative active site [active] 595496006090 heme pocket [chemical binding]; other site 595496006091 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 595496006092 putative active site [active] 595496006093 heme pocket [chemical binding]; other site 595496006094 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 595496006095 putative active site [active] 595496006096 heme pocket [chemical binding]; other site 595496006097 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 595496006098 metal binding site [ion binding]; metal-binding site 595496006099 active site 595496006100 I-site; other site 595496006101 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 595496006102 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 595496006103 AlkA N-terminal domain; Region: AlkA_N; smart01009 595496006104 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 595496006105 minor groove reading motif; other site 595496006106 helix-hairpin-helix signature motif; other site 595496006107 substrate binding pocket [chemical binding]; other site 595496006108 active site 595496006109 putative chaperone; Provisional; Region: PRK11678 595496006110 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 595496006111 nucleotide binding site [chemical binding]; other site 595496006112 putative NEF/HSP70 interaction site [polypeptide binding]; other site 595496006113 SBD interface [polypeptide binding]; other site 595496006114 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 595496006115 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 595496006116 substrate binding site [chemical binding]; other site 595496006117 activation loop (A-loop); other site 595496006118 Y-family of DNA polymerases; Region: PolY; cl12025 595496006119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 595496006120 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077 595496006121 Protein phosphatase 2C; Region: PP2C_2; pfam13672 595496006122 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 595496006123 metal ion-dependent adhesion site (MIDAS); other site 595496006124 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 595496006125 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 595496006126 HlyD family secretion protein; Region: HlyD_3; pfam13437 595496006127 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 595496006128 Protein export membrane protein; Region: SecD_SecF; cl14618 595496006129 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 595496006130 putative transporter; Provisional; Region: PRK10504 595496006131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496006132 putative substrate translocation pore; other site 595496006133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496006134 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 595496006135 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 595496006136 dimerization interface [polypeptide binding]; other site 595496006137 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 595496006138 dimer interface [polypeptide binding]; other site 595496006139 phosphorylation site [posttranslational modification] 595496006140 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 595496006141 ATP binding site [chemical binding]; other site 595496006142 Mg2+ binding site [ion binding]; other site 595496006143 G-X-G motif; other site 595496006144 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 595496006145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 595496006146 active site 595496006147 phosphorylation site [posttranslational modification] 595496006148 intermolecular recognition site; other site 595496006149 dimerization interface [polypeptide binding]; other site 595496006150 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 595496006151 DNA binding site [nucleotide binding] 595496006152 Uncharacterized conserved protein [Function unknown]; Region: COG3422 595496006153 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 595496006154 putative protease; Provisional; Region: PRK15452 595496006155 Peptidase family U32; Region: Peptidase_U32; pfam01136 595496006156 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 595496006157 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 595496006158 lipid kinase; Reviewed; Region: PRK13054 595496006159 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 595496006160 Transposase; Region: HTH_Tnp_1; cl17663 595496006161 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 595496006162 putative transposase OrfB; Reviewed; Region: PHA02517 595496006163 HTH-like domain; Region: HTH_21; pfam13276 595496006164 Integrase core domain; Region: rve; pfam00665 595496006165 Integrase core domain; Region: rve_2; pfam13333 595496006166 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 595496006167 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 595496006168 putative NAD(P) binding site [chemical binding]; other site 595496006169 catalytic Zn binding site [ion binding]; other site 595496006170 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 595496006171 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 595496006172 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 595496006173 active site 595496006174 P-loop; other site 595496006175 phosphorylation site [posttranslational modification] 595496006176 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 595496006177 active site 595496006178 phosphorylation site [posttranslational modification] 595496006179 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 595496006180 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 595496006181 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 595496006182 intersubunit interface [polypeptide binding]; other site 595496006183 active site 595496006184 zinc binding site [ion binding]; other site 595496006185 Na+ binding site [ion binding]; other site 595496006186 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 595496006187 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 595496006188 putative active site; other site 595496006189 catalytic residue [active] 595496006190 nucleoside transporter; Region: 2A0110; TIGR00889 595496006191 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496006192 putative substrate translocation pore; other site 595496006193 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 595496006194 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 595496006195 YegV-like sugar kinase. Found only in bacteria, YegV-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YegV_kinase_like; cd01944 595496006196 substrate binding site [chemical binding]; other site 595496006197 ATP binding site [chemical binding]; other site 595496006198 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 595496006199 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 595496006200 DNA-binding site [nucleotide binding]; DNA binding site 595496006201 UTRA domain; Region: UTRA; pfam07702 595496006202 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 595496006203 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 595496006204 active site 595496006205 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 595496006206 dimer interface [polypeptide binding]; other site 595496006207 substrate binding site [chemical binding]; other site 595496006208 ATP binding site [chemical binding]; other site 595496006209 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 595496006210 substrate binding site [chemical binding]; other site 595496006211 multimerization interface [polypeptide binding]; other site 595496006212 ATP binding site [chemical binding]; other site 595496006213 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 595496006214 putative metal binding site [ion binding]; other site 595496006215 putative homodimer interface [polypeptide binding]; other site 595496006216 putative homotetramer interface [polypeptide binding]; other site 595496006217 putative homodimer-homodimer interface [polypeptide binding]; other site 595496006218 putative allosteric switch controlling residues; other site 595496006219 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 595496006220 Predicted integral membrane protein [Function unknown]; Region: COG5455 595496006221 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 595496006222 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 595496006223 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 595496006224 PapC N-terminal domain; Region: PapC_N; pfam13954 595496006225 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 595496006226 PapC C-terminal domain; Region: PapC_C; pfam13953 595496006227 putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253 595496006228 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 595496006229 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 595496006230 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 595496006231 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 595496006232 antiporter inner membrane protein; Provisional; Region: PRK11670 595496006233 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 595496006234 Walker A motif; other site 595496006235 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 595496006236 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 595496006237 active site 595496006238 HIGH motif; other site 595496006239 KMSKS motif; other site 595496006240 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 595496006241 tRNA binding surface [nucleotide binding]; other site 595496006242 anticodon binding site; other site 595496006243 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 595496006244 dimer interface [polypeptide binding]; other site 595496006245 putative tRNA-binding site [nucleotide binding]; other site 595496006246 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 595496006247 MoxR-like ATPases [General function prediction only]; Region: COG0714 595496006248 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 595496006249 Walker A motif; other site 595496006250 ATP binding site [chemical binding]; other site 595496006251 Walker B motif; other site 595496006252 arginine finger; other site 595496006253 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 595496006254 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 595496006255 metal ion-dependent adhesion site (MIDAS); other site 595496006256 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 595496006257 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 595496006258 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 595496006259 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 595496006260 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 595496006261 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 595496006262 active site 595496006263 phosphorylation site [posttranslational modification] 595496006264 intermolecular recognition site; other site 595496006265 dimerization interface [polypeptide binding]; other site 595496006266 LytTr DNA-binding domain; Region: LytTR; pfam04397 595496006267 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 595496006268 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 595496006269 GAF domain; Region: GAF; pfam01590 595496006270 Histidine kinase; Region: His_kinase; pfam06580 595496006271 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 595496006272 ATP binding site [chemical binding]; other site 595496006273 Mg2+ binding site [ion binding]; other site 595496006274 G-X-G motif; other site 595496006275 transcriptional regulator MirA; Provisional; Region: PRK15043 595496006276 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 595496006277 DNA binding residues [nucleotide binding] 595496006278 hypothetical protein; Provisional; Region: PRK13681 595496006279 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 595496006280 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496006281 dimer interface [polypeptide binding]; other site 595496006282 conserved gate region; other site 595496006283 putative PBP binding loops; other site 595496006284 ABC-ATPase subunit interface; other site 595496006285 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 595496006286 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 595496006287 Walker A/P-loop; other site 595496006288 ATP binding site [chemical binding]; other site 595496006289 Q-loop/lid; other site 595496006290 ABC transporter signature motif; other site 595496006291 Walker B; other site 595496006292 D-loop; other site 595496006293 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 595496006294 H-loop/switch region; other site 595496006295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496006296 dimer interface [polypeptide binding]; other site 595496006297 conserved gate region; other site 595496006298 ABC-ATPase subunit interface; other site 595496006299 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 595496006300 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 595496006301 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 595496006302 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 595496006303 D-lactate dehydrogenase; Provisional; Region: PRK11183 595496006304 FAD binding domain; Region: FAD_binding_4; pfam01565 595496006305 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 595496006306 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 595496006307 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 595496006308 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 595496006309 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 595496006310 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 595496006311 oxidoreductase; Provisional; Region: PRK12743 595496006312 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 595496006313 NAD(P) binding site [chemical binding]; other site 595496006314 active site 595496006315 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 595496006316 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 595496006317 FMN binding site [chemical binding]; other site 595496006318 active site 595496006319 catalytic residues [active] 595496006320 substrate binding site [chemical binding]; other site 595496006321 hypothetical protein; Provisional; Region: PRK01821 595496006322 hypothetical protein; Provisional; Region: PRK10711 595496006323 cytidine deaminase; Provisional; Region: PRK09027 595496006324 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 595496006325 active site 595496006326 catalytic motif [active] 595496006327 Zn binding site [ion binding]; other site 595496006328 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 595496006329 active site 595496006330 catalytic motif [active] 595496006331 Zn binding site [ion binding]; other site 595496006332 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 595496006333 putative active site [active] 595496006334 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 595496006335 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 595496006336 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 595496006337 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 595496006338 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 595496006339 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 595496006340 homodimer interface [polypeptide binding]; other site 595496006341 active site 595496006342 FMN binding site [chemical binding]; other site 595496006343 substrate binding site [chemical binding]; other site 595496006344 4Fe-4S binding domain; Region: Fer4; pfam00037 595496006345 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 595496006346 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 595496006347 TM-ABC transporter signature motif; other site 595496006348 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 595496006349 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 595496006350 Walker A/P-loop; other site 595496006351 ATP binding site [chemical binding]; other site 595496006352 Q-loop/lid; other site 595496006353 ABC transporter signature motif; other site 595496006354 Walker B; other site 595496006355 D-loop; other site 595496006356 H-loop/switch region; other site 595496006357 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 595496006358 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 595496006359 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 595496006360 ligand binding site [chemical binding]; other site 595496006361 calcium binding site [ion binding]; other site 595496006362 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 595496006363 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 595496006364 DNA binding site [nucleotide binding] 595496006365 domain linker motif; other site 595496006366 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 595496006367 dimerization interface (closed form) [polypeptide binding]; other site 595496006368 ligand binding site [chemical binding]; other site 595496006369 Predicted membrane protein [Function unknown]; Region: COG2311 595496006370 hypothetical protein; Provisional; Region: PRK10835 595496006371 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 595496006372 homodecamer interface [polypeptide binding]; other site 595496006373 GTP cyclohydrolase I; Provisional; Region: PLN03044 595496006374 active site 595496006375 putative catalytic site residues [active] 595496006376 zinc binding site [ion binding]; other site 595496006377 GTP-CH-I/GFRP interaction surface; other site 595496006378 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 595496006379 S-formylglutathione hydrolase; Region: PLN02442 595496006380 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 595496006381 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 595496006382 N-terminal plug; other site 595496006383 ligand-binding site [chemical binding]; other site 595496006384 lysine transporter; Provisional; Region: PRK10836 595496006385 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 595496006386 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496006387 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 595496006388 putative dimerization interface [polypeptide binding]; other site 595496006389 conserved hypothetical integral membrane protein; Region: TIGR00698 595496006390 endonuclease IV; Provisional; Region: PRK01060 595496006391 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 595496006392 AP (apurinic/apyrimidinic) site pocket; other site 595496006393 DNA interaction; other site 595496006394 Metal-binding active site; metal-binding site 595496006395 putative kinase; Provisional; Region: PRK09954 595496006396 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 595496006397 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 595496006398 substrate binding site [chemical binding]; other site 595496006399 ATP binding site [chemical binding]; other site 595496006400 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 595496006401 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 595496006402 Nucleoside recognition; Region: Gate; pfam07670 595496006403 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 595496006404 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 595496006405 active site 595496006406 tetramer interface [polypeptide binding]; other site 595496006407 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 595496006408 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 595496006409 ligand binding site [chemical binding]; other site 595496006410 flexible hinge region; other site 595496006411 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 595496006412 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 595496006413 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 595496006414 Nucleoside recognition; Region: Gate; pfam07670 595496006415 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 595496006416 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 595496006417 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 595496006418 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 595496006419 substrate binding site [chemical binding]; other site 595496006420 ATP binding site [chemical binding]; other site 595496006421 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 595496006422 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 595496006423 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 595496006424 active site 595496006425 P-loop; other site 595496006426 phosphorylation site [posttranslational modification] 595496006427 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 595496006428 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 595496006429 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 595496006430 active site 595496006431 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 595496006432 NlpC/P60 family; Region: NLPC_P60; pfam00877 595496006433 phage resistance protein; Provisional; Region: PRK10551 595496006434 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 595496006435 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 595496006436 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 595496006437 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 595496006438 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 595496006439 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496006440 dimer interface [polypeptide binding]; other site 595496006441 conserved gate region; other site 595496006442 putative PBP binding loops; other site 595496006443 ABC-ATPase subunit interface; other site 595496006444 microcin C ABC transporter permease; Provisional; Region: PRK15021 595496006445 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496006446 dimer interface [polypeptide binding]; other site 595496006447 conserved gate region; other site 595496006448 ABC-ATPase subunit interface; other site 595496006449 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 595496006450 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 595496006451 Walker A/P-loop; other site 595496006452 ATP binding site [chemical binding]; other site 595496006453 Q-loop/lid; other site 595496006454 ABC transporter signature motif; other site 595496006455 Walker B; other site 595496006456 D-loop; other site 595496006457 H-loop/switch region; other site 595496006458 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 595496006459 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 595496006460 Walker A/P-loop; other site 595496006461 ATP binding site [chemical binding]; other site 595496006462 Q-loop/lid; other site 595496006463 ABC transporter signature motif; other site 595496006464 Walker B; other site 595496006465 D-loop; other site 595496006466 H-loop/switch region; other site 595496006467 hypothetical protein; Provisional; Region: PRK11835 595496006468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496006469 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 595496006470 putative substrate translocation pore; other site 595496006471 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 595496006472 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 595496006473 RNA binding surface [nucleotide binding]; other site 595496006474 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 595496006475 active site 595496006476 uracil binding [chemical binding]; other site 595496006477 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 595496006478 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 595496006479 ATP binding site [chemical binding]; other site 595496006480 putative Mg++ binding site [ion binding]; other site 595496006481 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 595496006482 nucleotide binding region [chemical binding]; other site 595496006483 ATP-binding site [chemical binding]; other site 595496006484 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 595496006485 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 595496006486 5S rRNA interface [nucleotide binding]; other site 595496006487 CTC domain interface [polypeptide binding]; other site 595496006488 L16 interface [polypeptide binding]; other site 595496006489 Nucleoid-associated protein [General function prediction only]; Region: COG3081 595496006490 nucleoid-associated protein NdpA; Validated; Region: PRK00378 595496006491 hypothetical protein; Provisional; Region: PRK13689 595496006492 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 595496006493 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 595496006494 Sulfatase; Region: Sulfatase; pfam00884 595496006495 Transposase domain (DUF772); Region: DUF772; pfam05598 595496006496 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 595496006497 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 595496006498 transcriptional regulator NarP; Provisional; Region: PRK10403 595496006499 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 595496006500 active site 595496006501 phosphorylation site [posttranslational modification] 595496006502 intermolecular recognition site; other site 595496006503 dimerization interface [polypeptide binding]; other site 595496006504 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 595496006505 DNA binding residues [nucleotide binding] 595496006506 dimerization interface [polypeptide binding]; other site 595496006507 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 595496006508 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 595496006509 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 595496006510 binding surface 595496006511 TPR motif; other site 595496006512 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 595496006513 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 595496006514 catalytic residues [active] 595496006515 central insert; other site 595496006516 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 595496006517 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 595496006518 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 595496006519 heme exporter protein CcmC; Region: ccmC; TIGR01191 595496006520 heme exporter protein CcmB; Region: ccmB; TIGR01190 595496006521 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 595496006522 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 595496006523 Walker A/P-loop; other site 595496006524 ATP binding site [chemical binding]; other site 595496006525 Q-loop/lid; other site 595496006526 ABC transporter signature motif; other site 595496006527 Walker B; other site 595496006528 D-loop; other site 595496006529 H-loop/switch region; other site 595496006530 cytochrome c-type protein NapC; Provisional; Region: PRK10617 595496006531 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 595496006532 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 595496006533 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 595496006534 4Fe-4S binding domain; Region: Fer4_5; pfam12801 595496006535 4Fe-4S binding domain; Region: Fer4_6; pfam12837 595496006536 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 595496006537 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 595496006538 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 595496006539 [4Fe-4S] binding site [ion binding]; other site 595496006540 molybdopterin cofactor binding site; other site 595496006541 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 595496006542 molybdopterin cofactor binding site; other site 595496006543 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 595496006544 ferredoxin-type protein; Provisional; Region: PRK10194 595496006545 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 595496006546 secondary substrate binding site; other site 595496006547 primary substrate binding site; other site 595496006548 inhibition loop; other site 595496006549 dimerization interface [polypeptide binding]; other site 595496006550 malate:quinone oxidoreductase; Validated; Region: PRK05257 595496006551 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 595496006552 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 595496006553 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 595496006554 Walker A/P-loop; other site 595496006555 ATP binding site [chemical binding]; other site 595496006556 Q-loop/lid; other site 595496006557 ABC transporter signature motif; other site 595496006558 Walker B; other site 595496006559 D-loop; other site 595496006560 H-loop/switch region; other site 595496006561 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 595496006562 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 595496006563 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 595496006564 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 595496006565 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 595496006566 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 595496006567 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 595496006568 DNA binding site [nucleotide binding] 595496006569 active site 595496006570 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 595496006571 ApbE family; Region: ApbE; pfam02424 595496006572 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 595496006573 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 595496006574 trimer interface [polypeptide binding]; other site 595496006575 eyelet of channel; other site 595496006576 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 595496006577 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 595496006578 ATP binding site [chemical binding]; other site 595496006579 G-X-G motif; other site 595496006580 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 595496006581 putative binding surface; other site 595496006582 active site 595496006583 transcriptional regulator RcsB; Provisional; Region: PRK10840 595496006584 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 595496006585 active site 595496006586 phosphorylation site [posttranslational modification] 595496006587 intermolecular recognition site; other site 595496006588 dimerization interface [polypeptide binding]; other site 595496006589 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 595496006590 DNA binding residues [nucleotide binding] 595496006591 dimerization interface [polypeptide binding]; other site 595496006592 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 595496006593 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 595496006594 dimer interface [polypeptide binding]; other site 595496006595 phosphorylation site [posttranslational modification] 595496006596 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 595496006597 ATP binding site [chemical binding]; other site 595496006598 Mg2+ binding site [ion binding]; other site 595496006599 G-X-G motif; other site 595496006600 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 595496006601 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 595496006602 active site 595496006603 phosphorylation site [posttranslational modification] 595496006604 intermolecular recognition site; other site 595496006605 dimerization interface [polypeptide binding]; other site 595496006606 sensory histidine kinase AtoS; Provisional; Region: PRK11360 595496006607 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 595496006608 putative active site [active] 595496006609 heme pocket [chemical binding]; other site 595496006610 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 595496006611 dimer interface [polypeptide binding]; other site 595496006612 phosphorylation site [posttranslational modification] 595496006613 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 595496006614 ATP binding site [chemical binding]; other site 595496006615 Mg2+ binding site [ion binding]; other site 595496006616 G-X-G motif; other site 595496006617 acetoacetate metabolism regulatory protein AtoC; Provisional; Region: PRK11361 595496006618 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 595496006619 active site 595496006620 phosphorylation site [posttranslational modification] 595496006621 intermolecular recognition site; other site 595496006622 dimerization interface [polypeptide binding]; other site 595496006623 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 595496006624 Walker A motif; other site 595496006625 ATP binding site [chemical binding]; other site 595496006626 Walker B motif; other site 595496006627 arginine finger; other site 595496006628 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 595496006629 acetyl-CoA:acetoacetyl-CoA transferase subunit alpha; Provisional; Region: PRK09920 595496006630 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 595496006631 Short chain fatty acid transporter; Region: SCFA_trans; pfam02667 595496006632 putative acyltransferase; Provisional; Region: PRK05790 595496006633 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 595496006634 dimer interface [polypeptide binding]; other site 595496006635 active site 595496006636 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 595496006637 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 595496006638 Predicted secreted protein [Function unknown]; Region: COG5445 595496006639 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 595496006640 Predicted secreted protein [Function unknown]; Region: COG5445 595496006641 Stage II sporulation protein; Region: SpoIID; pfam08486 595496006642 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 595496006643 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 595496006644 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4685 595496006645 DNA gyrase subunit A; Validated; Region: PRK05560 595496006646 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 595496006647 CAP-like domain; other site 595496006648 active site 595496006649 primary dimer interface [polypeptide binding]; other site 595496006650 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 595496006651 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 595496006652 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 595496006653 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 595496006654 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 595496006655 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 595496006656 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 595496006657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 595496006658 S-adenosylmethionine binding site [chemical binding]; other site 595496006659 adhesin; Provisional; Region: PRK09752 595496006660 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 595496006661 Autotransporter beta-domain; Region: Autotransporter; pfam03797 595496006662 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 595496006663 ATP cone domain; Region: ATP-cone; pfam03477 595496006664 Class I ribonucleotide reductase; Region: RNR_I; cd01679 595496006665 active site 595496006666 dimer interface [polypeptide binding]; other site 595496006667 catalytic residues [active] 595496006668 effector binding site; other site 595496006669 R2 peptide binding site; other site 595496006670 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 595496006671 dimer interface [polypeptide binding]; other site 595496006672 putative radical transfer pathway; other site 595496006673 diiron center [ion binding]; other site 595496006674 tyrosyl radical; other site 595496006675 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 595496006676 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 595496006677 catalytic loop [active] 595496006678 iron binding site [ion binding]; other site 595496006679 hypothetical protein; Provisional; Region: PRK09902 595496006680 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 595496006681 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 595496006682 active site 595496006683 catalytic site [active] 595496006684 metal binding site [ion binding]; metal-binding site 595496006685 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 595496006686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496006687 putative substrate translocation pore; other site 595496006688 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 595496006689 hydroxyglutarate oxidase; Provisional; Region: PRK11728 595496006690 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 595496006691 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 595496006692 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 595496006693 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 595496006694 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 595496006695 Cysteine-rich domain; Region: CCG; pfam02754 595496006696 Cysteine-rich domain; Region: CCG; pfam02754 595496006697 hypothetical protein; Provisional; Region: PRK09956 595496006698 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 595496006699 hypothetical protein; Provisional; Region: PRK09956 595496006700 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 595496006701 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 595496006702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496006703 putative substrate translocation pore; other site 595496006704 L-rhamnonate dehydratase; Provisional; Region: PRK15440 595496006705 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 595496006706 putative active site pocket [active] 595496006707 putative metal binding site [ion binding]; other site 595496006708 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 595496006709 Transcriptional regulator [Transcription]; Region: IclR; COG1414 595496006710 Bacterial transcriptional regulator; Region: IclR; pfam01614 595496006711 hypothetical protein; Provisional; Region: PRK03673 595496006712 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 595496006713 putative MPT binding site; other site 595496006714 Competence-damaged protein; Region: CinA; cl00666 595496006715 YfaZ precursor; Region: YfaZ; pfam07437 595496006716 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 595496006717 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 595496006718 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 595496006719 catalytic core [active] 595496006720 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 595496006721 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 595496006722 inhibitor-cofactor binding pocket; inhibition site 595496006723 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496006724 catalytic residue [active] 595496006725 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 595496006726 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 595496006727 Ligand binding site; other site 595496006728 Putative Catalytic site; other site 595496006729 DXD motif; other site 595496006730 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 595496006731 ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644 595496006732 substrate binding site [chemical binding]; other site 595496006733 cosubstrate binding site; other site 595496006734 catalytic site [active] 595496006735 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 595496006736 active site 595496006737 hexamer interface [polypeptide binding]; other site 595496006738 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 595496006739 NAD binding site [chemical binding]; other site 595496006740 substrate binding site [chemical binding]; other site 595496006741 active site 595496006742 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 595496006743 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 595496006744 putative active site [active] 595496006745 putative catalytic site [active] 595496006746 putative Zn binding site [ion binding]; other site 595496006747 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 595496006748 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 595496006749 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 595496006750 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 595496006751 signal transduction protein PmrD; Provisional; Region: PRK15450 595496006752 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 595496006753 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 595496006754 acyl-activating enzyme (AAE) consensus motif; other site 595496006755 putative AMP binding site [chemical binding]; other site 595496006756 putative active site [active] 595496006757 putative CoA binding site [chemical binding]; other site 595496006758 O-succinylbenzoate synthase; Provisional; Region: PRK05105 595496006759 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 595496006760 active site 595496006761 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 595496006762 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 595496006763 substrate binding site [chemical binding]; other site 595496006764 oxyanion hole (OAH) forming residues; other site 595496006765 trimer interface [polypeptide binding]; other site 595496006766 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 595496006767 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 595496006768 nucleophilic elbow; other site 595496006769 catalytic triad; other site 595496006770 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 595496006771 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 595496006772 dimer interface [polypeptide binding]; other site 595496006773 tetramer interface [polypeptide binding]; other site 595496006774 PYR/PP interface [polypeptide binding]; other site 595496006775 TPP binding site [chemical binding]; other site 595496006776 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 595496006777 TPP-binding site; other site 595496006778 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 595496006779 isochorismate synthases; Region: isochor_syn; TIGR00543 595496006780 hypothetical protein; Provisional; Region: PRK10404 595496006781 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 595496006782 Coenzyme A binding pocket [chemical binding]; other site 595496006783 ribonuclease BN; Region: true_RNase_BN; TIGR02649 595496006784 deubiquitinase; Provisional; Region: PRK11836 595496006785 von Willebrand factor; Region: vWF_A; pfam12450 595496006786 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 595496006787 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 595496006788 metal ion-dependent adhesion site (MIDAS); other site 595496006789 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 595496006790 M28 Zn-Peptidases; Region: M28_like_1; cd05640 595496006791 Peptidase family M28; Region: Peptidase_M28; pfam04389 595496006792 metal binding site [ion binding]; metal-binding site 595496006793 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 595496006794 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 595496006795 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 595496006796 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 595496006797 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 595496006798 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 595496006799 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 595496006800 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 595496006801 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 595496006802 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 595496006803 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 595496006804 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 595496006805 4Fe-4S binding domain; Region: Fer4; pfam00037 595496006806 4Fe-4S binding domain; Region: Fer4; pfam00037 595496006807 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 595496006808 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 595496006809 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 595496006810 catalytic loop [active] 595496006811 iron binding site [ion binding]; other site 595496006812 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 595496006813 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 595496006814 [4Fe-4S] binding site [ion binding]; other site 595496006815 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 595496006816 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 595496006817 SLBB domain; Region: SLBB; pfam10531 595496006818 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 595496006819 NADH dehydrogenase subunit E; Validated; Region: PRK07539 595496006820 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 595496006821 putative dimer interface [polypeptide binding]; other site 595496006822 [2Fe-2S] cluster binding site [ion binding]; other site 595496006823 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 595496006824 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 595496006825 NADH dehydrogenase subunit D; Validated; Region: PRK06075 595496006826 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 595496006827 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 595496006828 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 595496006829 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496006830 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 595496006831 putative dimerization interface [polypeptide binding]; other site 595496006832 aminotransferase AlaT; Validated; Region: PRK09265 595496006833 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 595496006834 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496006835 homodimer interface [polypeptide binding]; other site 595496006836 catalytic residue [active] 595496006837 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 595496006838 Zn2+ binding site [ion binding]; other site 595496006839 Mg2+ binding site [ion binding]; other site 595496006840 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 595496006841 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 595496006842 TrkA-C domain; Region: TrkA_C; pfam02080 595496006843 TrkA-C domain; Region: TrkA_C; pfam02080 595496006844 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 595496006845 putative phosphatase; Provisional; Region: PRK11587 595496006846 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 595496006847 motif II; other site 595496006848 hypothetical protein; Validated; Region: PRK05445 595496006849 hypothetical protein; Provisional; Region: PRK01816 595496006850 propionate/acetate kinase; Provisional; Region: PRK12379 595496006851 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 595496006852 phosphate acetyltransferase; Reviewed; Region: PRK05632 595496006853 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 595496006854 DRTGG domain; Region: DRTGG; pfam07085 595496006855 phosphate acetyltransferase; Region: pta; TIGR00651 595496006856 hypothetical protein; Provisional; Region: PRK11588 595496006857 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 595496006858 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 595496006859 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 595496006860 nudix motif; other site 595496006861 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 595496006862 active site 595496006863 metal binding site [ion binding]; metal-binding site 595496006864 homotetramer interface [polypeptide binding]; other site 595496006865 glutathione S-transferase; Provisional; Region: PRK15113 595496006866 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 595496006867 C-terminal domain interface [polypeptide binding]; other site 595496006868 GSH binding site (G-site) [chemical binding]; other site 595496006869 dimer interface [polypeptide binding]; other site 595496006870 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 595496006871 N-terminal domain interface [polypeptide binding]; other site 595496006872 putative dimer interface [polypeptide binding]; other site 595496006873 putative substrate binding pocket (H-site) [chemical binding]; other site 595496006874 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 595496006875 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 595496006876 C-terminal domain interface [polypeptide binding]; other site 595496006877 GSH binding site (G-site) [chemical binding]; other site 595496006878 dimer interface [polypeptide binding]; other site 595496006879 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 595496006880 N-terminal domain interface [polypeptide binding]; other site 595496006881 putative dimer interface [polypeptide binding]; other site 595496006882 active site 595496006883 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 595496006884 homooctamer interface [polypeptide binding]; other site 595496006885 active site 595496006886 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 595496006887 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 595496006888 putative NAD(P) binding site [chemical binding]; other site 595496006889 putative active site [active] 595496006890 putative transposase; Provisional; Region: PRK09857 595496006891 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 595496006892 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 595496006893 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 595496006894 Walker A/P-loop; other site 595496006895 ATP binding site [chemical binding]; other site 595496006896 Q-loop/lid; other site 595496006897 ABC transporter signature motif; other site 595496006898 Walker B; other site 595496006899 D-loop; other site 595496006900 H-loop/switch region; other site 595496006901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496006902 dimer interface [polypeptide binding]; other site 595496006903 conserved gate region; other site 595496006904 putative PBP binding loops; other site 595496006905 ABC-ATPase subunit interface; other site 595496006906 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 595496006907 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496006908 dimer interface [polypeptide binding]; other site 595496006909 conserved gate region; other site 595496006910 putative PBP binding loops; other site 595496006911 ABC-ATPase subunit interface; other site 595496006912 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 595496006913 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 595496006914 substrate binding pocket [chemical binding]; other site 595496006915 membrane-bound complex binding site; other site 595496006916 hinge residues; other site 595496006917 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 595496006918 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 595496006919 substrate binding pocket [chemical binding]; other site 595496006920 membrane-bound complex binding site; other site 595496006921 hinge residues; other site 595496006922 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 595496006923 Flavoprotein; Region: Flavoprotein; pfam02441 595496006924 amidophosphoribosyltransferase; Provisional; Region: PRK09246 595496006925 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 595496006926 active site 595496006927 tetramer interface [polypeptide binding]; other site 595496006928 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 595496006929 active site 595496006930 colicin V production protein; Provisional; Region: PRK10845 595496006931 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 595496006932 cell division protein DedD; Provisional; Region: PRK11633 595496006933 Sporulation related domain; Region: SPOR; pfam05036 595496006934 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 595496006935 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 595496006936 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 595496006937 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 595496006938 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 595496006939 hypothetical protein; Provisional; Region: PRK10847 595496006940 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 595496006941 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 595496006942 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 595496006943 dimerization interface 3.5A [polypeptide binding]; other site 595496006944 active site 595496006945 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 595496006946 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 595496006947 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 595496006948 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 595496006949 ligand binding site [chemical binding]; other site 595496006950 NAD binding site [chemical binding]; other site 595496006951 catalytic site [active] 595496006952 homodimer interface [polypeptide binding]; other site 595496006953 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 595496006954 putative transporter; Provisional; Region: PRK12382 595496006955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496006956 putative substrate translocation pore; other site 595496006957 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 595496006958 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 595496006959 dimer interface [polypeptide binding]; other site 595496006960 active site 595496006961 Uncharacterized conserved protein [Function unknown]; Region: COG4121 595496006962 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 595496006963 YfcL protein; Region: YfcL; pfam08891 595496006964 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 595496006965 hypothetical protein; Provisional; Region: PRK10621 595496006966 Predicted permeases [General function prediction only]; Region: COG0730 595496006967 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 595496006968 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 595496006969 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 595496006970 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 595496006971 Tetramer interface [polypeptide binding]; other site 595496006972 active site 595496006973 FMN-binding site [chemical binding]; other site 595496006974 HemK family putative methylases; Region: hemK_fam; TIGR00536 595496006975 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 595496006976 S-adenosylmethionine binding site [chemical binding]; other site 595496006977 hypothetical protein; Provisional; Region: PRK04946 595496006978 Smr domain; Region: Smr; pfam01713 595496006979 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 595496006980 Fimbrial protein; Region: Fimbrial; cl01416 595496006981 Fimbrial protein; Region: Fimbrial; cl01416 595496006982 Fimbrial protein; Region: Fimbrial; cl01416 595496006983 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 595496006984 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 595496006985 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 595496006986 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 595496006987 catalytic core [active] 595496006988 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 595496006989 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 595496006990 substrate binding site [chemical binding]; other site 595496006991 oxyanion hole (OAH) forming residues; other site 595496006992 trimer interface [polypeptide binding]; other site 595496006993 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 595496006994 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 595496006995 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 595496006996 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 595496006997 dimer interface [polypeptide binding]; other site 595496006998 active site 595496006999 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 595496007000 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 595496007001 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 595496007002 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 595496007003 integrase; Provisional; Region: PRK09692 595496007004 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 595496007005 active site 595496007006 Int/Topo IB signature motif; other site 595496007007 Predicted membrane protein [Function unknown]; Region: COG2246 595496007008 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 595496007009 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 595496007010 Ligand binding site; other site 595496007011 Putative Catalytic site; other site 595496007012 DXD motif; other site 595496007013 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 595496007014 PerC transcriptional activator; Region: PerC; pfam06069 595496007015 Uncharacterized conserved protein [Function unknown]; Region: COG5532 595496007016 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 595496007017 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 595496007018 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 595496007019 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496007020 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 595496007021 dimerization interface [polypeptide binding]; other site 595496007022 substrate binding pocket [chemical binding]; other site 595496007023 permease DsdX; Provisional; Region: PRK09921 595496007024 gluconate transporter; Region: gntP; TIGR00791 595496007025 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 595496007026 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 595496007027 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 595496007028 catalytic residue [active] 595496007029 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 595496007030 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496007031 putative substrate translocation pore; other site 595496007032 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496007033 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 595496007034 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 595496007035 HlyD family secretion protein; Region: HlyD_3; pfam13437 595496007036 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 595496007037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 595496007038 active site 595496007039 phosphorylation site [posttranslational modification] 595496007040 intermolecular recognition site; other site 595496007041 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 595496007042 DNA binding residues [nucleotide binding] 595496007043 dimerization interface [polypeptide binding]; other site 595496007044 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 595496007045 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 595496007046 substrate binding pocket [chemical binding]; other site 595496007047 membrane-bound complex binding site; other site 595496007048 hinge residues; other site 595496007049 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 595496007050 substrate binding pocket [chemical binding]; other site 595496007051 membrane-bound complex binding site; other site 595496007052 hinge residues; other site 595496007053 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 595496007054 dimer interface [polypeptide binding]; other site 595496007055 phosphorylation site [posttranslational modification] 595496007056 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 595496007057 ATP binding site [chemical binding]; other site 595496007058 Mg2+ binding site [ion binding]; other site 595496007059 G-X-G motif; other site 595496007060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 595496007061 active site 595496007062 phosphorylation site [posttranslational modification] 595496007063 intermolecular recognition site; other site 595496007064 dimerization interface [polypeptide binding]; other site 595496007065 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 595496007066 putative binding surface; other site 595496007067 active site 595496007068 putative CoA-transferase; Provisional; Region: PRK11430 595496007069 CoA-transferase family III; Region: CoA_transf_3; pfam02515 595496007070 putative transporter YfdV; Provisional; Region: PRK09903 595496007071 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 595496007072 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 595496007073 PYR/PP interface [polypeptide binding]; other site 595496007074 dimer interface [polypeptide binding]; other site 595496007075 TPP binding site [chemical binding]; other site 595496007076 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 595496007077 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 595496007078 TPP-binding site; other site 595496007079 dimer interface [polypeptide binding]; other site 595496007080 formyl-coenzyme A transferase; Provisional; Region: PRK05398 595496007081 CoA-transferase family III; Region: CoA_transf_3; pfam02515 595496007082 hypothetical protein; Provisional; Region: PRK10316 595496007083 YfdX protein; Region: YfdX; pfam10938 595496007084 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 595496007085 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 595496007086 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 595496007087 putative acyl-acceptor binding pocket; other site 595496007088 aminotransferase; Validated; Region: PRK08175 595496007089 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 595496007090 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496007091 homodimer interface [polypeptide binding]; other site 595496007092 catalytic residue [active] 595496007093 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 595496007094 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 595496007095 GAF domain; Region: GAF; pfam01590 595496007096 Histidine kinase; Region: His_kinase; pfam06580 595496007097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 595496007098 ATP binding site [chemical binding]; other site 595496007099 Mg2+ binding site [ion binding]; other site 595496007100 G-X-G motif; other site 595496007101 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 595496007102 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 595496007103 active site 595496007104 phosphorylation site [posttranslational modification] 595496007105 intermolecular recognition site; other site 595496007106 dimerization interface [polypeptide binding]; other site 595496007107 LytTr DNA-binding domain; Region: LytTR; pfam04397 595496007108 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 595496007109 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 595496007110 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 595496007111 dimerization domain swap beta strand [polypeptide binding]; other site 595496007112 regulatory protein interface [polypeptide binding]; other site 595496007113 active site 595496007114 regulatory phosphorylation site [posttranslational modification]; other site 595496007115 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 595496007116 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 595496007117 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 595496007118 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 595496007119 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 595496007120 active site 595496007121 phosphorylation site [posttranslational modification] 595496007122 exoaminopeptidase; Provisional; Region: PRK09961 595496007123 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 595496007124 oligomer interface [polypeptide binding]; other site 595496007125 active site 595496007126 metal binding site [ion binding]; metal-binding site 595496007127 aminopeptidase; Provisional; Region: PRK09795 595496007128 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 595496007129 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 595496007130 active site 595496007131 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 595496007132 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 595496007133 active site 595496007134 P-loop; other site 595496007135 phosphorylation site [posttranslational modification] 595496007136 glucokinase, proteobacterial type; Region: glk; TIGR00749 595496007137 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 595496007138 nucleotide binding site [chemical binding]; other site 595496007139 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 595496007140 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 595496007141 Cl- selectivity filter; other site 595496007142 Cl- binding residues [ion binding]; other site 595496007143 pore gating glutamate residue; other site 595496007144 dimer interface [polypeptide binding]; other site 595496007145 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 595496007146 manganese transport protein MntH; Reviewed; Region: PRK00701 595496007147 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 595496007148 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 595496007149 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 595496007150 Nucleoside recognition; Region: Gate; pfam07670 595496007151 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 595496007152 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 595496007153 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 595496007154 MASE1; Region: MASE1; pfam05231 595496007155 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 595496007156 diguanylate cyclase; Region: GGDEF; smart00267 595496007157 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 595496007158 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 595496007159 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 595496007160 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 595496007161 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 595496007162 active site 595496007163 HIGH motif; other site 595496007164 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 595496007165 active site 595496007166 KMSKS motif; other site 595496007167 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 595496007168 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496007169 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 595496007170 putative dimerization interface [polypeptide binding]; other site 595496007171 putative substrate binding pocket [chemical binding]; other site 595496007172 nucleoside transporter; Region: 2A0110; TIGR00889 595496007173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496007174 putative substrate translocation pore; other site 595496007175 purine nucleoside phosphorylase; Provisional; Region: PRK08202 595496007176 hypothetical protein; Provisional; Region: PRK11528 595496007177 Transcriptional regulator [Transcription]; Region: LysR; COG0583 595496007178 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496007179 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 595496007180 putative dimerization interface [polypeptide binding]; other site 595496007181 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 595496007182 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 595496007183 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 595496007184 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 595496007185 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 595496007186 nucleotide binding pocket [chemical binding]; other site 595496007187 K-X-D-G motif; other site 595496007188 catalytic site [active] 595496007189 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 595496007190 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 595496007191 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 595496007192 Dimer interface [polypeptide binding]; other site 595496007193 BRCT sequence motif; other site 595496007194 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 595496007195 cell division protein ZipA; Provisional; Region: PRK03427 595496007196 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 595496007197 FtsZ protein binding site [polypeptide binding]; other site 595496007198 putative sulfate transport protein CysZ; Validated; Region: PRK04949 595496007199 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 595496007200 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 595496007201 dimer interface [polypeptide binding]; other site 595496007202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496007203 catalytic residue [active] 595496007204 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 595496007205 dimerization domain swap beta strand [polypeptide binding]; other site 595496007206 regulatory protein interface [polypeptide binding]; other site 595496007207 active site 595496007208 regulatory phosphorylation site [posttranslational modification]; other site 595496007209 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 595496007210 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 595496007211 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 595496007212 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 595496007213 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 595496007214 HPr interaction site; other site 595496007215 glycerol kinase (GK) interaction site [polypeptide binding]; other site 595496007216 active site 595496007217 phosphorylation site [posttranslational modification] 595496007218 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 595496007219 dimer interface [polypeptide binding]; other site 595496007220 pyridoxamine kinase; Validated; Region: PRK05756 595496007221 pyridoxal binding site [chemical binding]; other site 595496007222 ATP binding site [chemical binding]; other site 595496007223 hypothetical protein; Provisional; Region: PRK10318 595496007224 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 595496007225 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884 595496007226 cysteine synthase B; Region: cysM; TIGR01138 595496007227 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 595496007228 dimer interface [polypeptide binding]; other site 595496007229 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496007230 catalytic residue [active] 595496007231 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 595496007232 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 595496007233 Walker A/P-loop; other site 595496007234 ATP binding site [chemical binding]; other site 595496007235 Q-loop/lid; other site 595496007236 ABC transporter signature motif; other site 595496007237 Walker B; other site 595496007238 D-loop; other site 595496007239 H-loop/switch region; other site 595496007240 TOBE-like domain; Region: TOBE_3; pfam12857 595496007241 sulfate transport protein; Provisional; Region: cysT; CHL00187 595496007242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496007243 dimer interface [polypeptide binding]; other site 595496007244 conserved gate region; other site 595496007245 putative PBP binding loops; other site 595496007246 ABC-ATPase subunit interface; other site 595496007247 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 595496007248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496007249 dimer interface [polypeptide binding]; other site 595496007250 conserved gate region; other site 595496007251 putative PBP binding loops; other site 595496007252 ABC-ATPase subunit interface; other site 595496007253 thiosulfate transporter subunit; Provisional; Region: PRK10852 595496007254 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 595496007255 short chain dehydrogenase; Provisional; Region: PRK08226 595496007256 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 595496007257 NAD binding site [chemical binding]; other site 595496007258 homotetramer interface [polypeptide binding]; other site 595496007259 homodimer interface [polypeptide binding]; other site 595496007260 active site 595496007261 transcriptional regulator MurR; Provisional; Region: PRK15482 595496007262 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 595496007263 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 595496007264 putative active site [active] 595496007265 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 595496007266 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 595496007267 putative active site [active] 595496007268 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 595496007269 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 595496007270 active site turn [active] 595496007271 phosphorylation site [posttranslational modification] 595496007272 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 595496007273 putative periplasmic esterase; Provisional; Region: PRK03642 595496007274 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 595496007275 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 595496007276 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 595496007277 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 595496007278 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 595496007279 putative acetyltransferase; Provisional; Region: PRK03624 595496007280 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 595496007281 Coenzyme A binding pocket [chemical binding]; other site 595496007282 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 595496007283 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 595496007284 active site 595496007285 metal binding site [ion binding]; metal-binding site 595496007286 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 595496007287 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 595496007288 transcriptional regulator EutR; Provisional; Region: PRK10130 595496007289 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 595496007290 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 595496007291 carboxysome structural protein EutK; Provisional; Region: PRK15466 595496007292 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 595496007293 Hexamer interface [polypeptide binding]; other site 595496007294 Hexagonal pore residue; other site 595496007295 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 595496007296 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 595496007297 putative hexamer interface [polypeptide binding]; other site 595496007298 putative hexagonal pore; other site 595496007299 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 595496007300 putative hexamer interface [polypeptide binding]; other site 595496007301 putative hexagonal pore; other site 595496007302 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 595496007303 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 595496007304 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 595496007305 integrase; Provisional; Region: PRK09692 595496007306 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 595496007307 active site 595496007308 Int/Topo IB signature motif; other site 595496007309 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 595496007310 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 595496007311 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 595496007312 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 595496007313 active site 595496007314 metal binding site [ion binding]; metal-binding site 595496007315 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 595496007316 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 595496007317 nucleotide binding site [chemical binding]; other site 595496007318 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 595496007319 putative catalytic cysteine [active] 595496007320 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 595496007321 Hexamer/Pentamer interface [polypeptide binding]; other site 595496007322 central pore; other site 595496007323 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 595496007324 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 595496007325 Hexamer interface [polypeptide binding]; other site 595496007326 Putative hexagonal pore residue; other site 595496007327 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 595496007328 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 595496007329 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 595496007330 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 595496007331 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 595496007332 G1 box; other site 595496007333 GTP/Mg2+ binding site [chemical binding]; other site 595496007334 G2 box; other site 595496007335 Switch I region; other site 595496007336 G3 box; other site 595496007337 Switch II region; other site 595496007338 G4 box; other site 595496007339 G5 box; other site 595496007340 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 595496007341 putative hexamer interface [polypeptide binding]; other site 595496007342 putative hexagonal pore; other site 595496007343 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 595496007344 Malic enzyme, N-terminal domain; Region: malic; pfam00390 595496007345 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 595496007346 putative NAD(P) binding site [chemical binding]; other site 595496007347 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 595496007348 transaldolase-like protein; Provisional; Region: PTZ00411 595496007349 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 595496007350 active site 595496007351 dimer interface [polypeptide binding]; other site 595496007352 catalytic residue [active] 595496007353 transketolase; Reviewed; Region: PRK12753 595496007354 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 595496007355 TPP-binding site [chemical binding]; other site 595496007356 dimer interface [polypeptide binding]; other site 595496007357 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 595496007358 PYR/PP interface [polypeptide binding]; other site 595496007359 dimer interface [polypeptide binding]; other site 595496007360 TPP binding site [chemical binding]; other site 595496007361 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 595496007362 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 595496007363 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 595496007364 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 595496007365 dimer interface [polypeptide binding]; other site 595496007366 ADP-ribose binding site [chemical binding]; other site 595496007367 active site 595496007368 nudix motif; other site 595496007369 metal binding site [ion binding]; metal-binding site 595496007370 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 595496007371 4Fe-4S binding domain; Region: Fer4; pfam00037 595496007372 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 595496007373 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 595496007374 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 595496007375 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 595496007376 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 595496007377 dimerization interface [polypeptide binding]; other site 595496007378 Histidine kinase; Region: HisKA_3; pfam07730 595496007379 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 595496007380 ATP binding site [chemical binding]; other site 595496007381 Mg2+ binding site [ion binding]; other site 595496007382 G-X-G motif; other site 595496007383 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 595496007384 Protein export membrane protein; Region: SecD_SecF; cl14618 595496007385 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 595496007386 ArsC family; Region: ArsC; pfam03960 595496007387 putative catalytic residues [active] 595496007388 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 595496007389 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 595496007390 metal binding site [ion binding]; metal-binding site 595496007391 dimer interface [polypeptide binding]; other site 595496007392 hypothetical protein; Provisional; Region: PRK13664 595496007393 putative hydrolase; Provisional; Region: PRK11460 595496007394 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 595496007395 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 595496007396 Helicase; Region: Helicase_RecD; pfam05127 595496007397 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 595496007398 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 595496007399 Predicted metalloprotease [General function prediction only]; Region: COG2321 595496007400 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 595496007401 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 595496007402 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 595496007403 ATP binding site [chemical binding]; other site 595496007404 active site 595496007405 substrate binding site [chemical binding]; other site 595496007406 lipoprotein; Provisional; Region: PRK11679 595496007407 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 595496007408 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 595496007409 dihydrodipicolinate synthase; Region: dapA; TIGR00674 595496007410 dimer interface [polypeptide binding]; other site 595496007411 active site 595496007412 catalytic residue [active] 595496007413 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 595496007414 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 595496007415 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 595496007416 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 595496007417 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 595496007418 catalytic triad [active] 595496007419 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 595496007420 4Fe-4S binding domain; Region: Fer4; pfam00037 595496007421 hydrogenase 4 subunit B; Validated; Region: PRK06521 595496007422 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 595496007423 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 595496007424 NADH dehydrogenase; Region: NADHdh; cl00469 595496007425 hydrogenase 4 subunit D; Validated; Region: PRK06525 595496007426 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 595496007427 hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492 595496007428 hydrogenase 4 subunit F; Validated; Region: PRK06458 595496007429 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 595496007430 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 595496007431 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 595496007432 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 595496007433 hydrogenase 4 subunit H; Validated; Region: PRK08222 595496007434 4Fe-4S binding domain; Region: Fer4; pfam00037 595496007435 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 595496007436 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 595496007437 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 595496007438 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 595496007439 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 595496007440 Walker A motif; other site 595496007441 ATP binding site [chemical binding]; other site 595496007442 Walker B motif; other site 595496007443 arginine finger; other site 595496007444 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 595496007445 putative formate transporter; Provisional; Region: focB; PRK09713 595496007446 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 595496007447 Domain of unknown function DUF20; Region: UPF0118; pfam01594 595496007448 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 595496007449 Peptidase family M48; Region: Peptidase_M48; cl12018 595496007450 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 595496007451 ArsC family; Region: ArsC; pfam03960 595496007452 catalytic residues [active] 595496007453 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 595496007454 DNA replication initiation factor; Provisional; Region: PRK08084 595496007455 uracil transporter; Provisional; Region: PRK10720 595496007456 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 595496007457 active site 595496007458 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 595496007459 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 595496007460 dimerization interface [polypeptide binding]; other site 595496007461 putative ATP binding site [chemical binding]; other site 595496007462 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 595496007463 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 595496007464 active site 595496007465 substrate binding site [chemical binding]; other site 595496007466 cosubstrate binding site; other site 595496007467 catalytic site [active] 595496007468 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 595496007469 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 595496007470 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 595496007471 Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114 595496007472 domain interface [polypeptide binding]; other site 595496007473 active site 595496007474 catalytic site [active] 595496007475 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 595496007476 putative active site [active] 595496007477 catalytic site [active] 595496007478 exopolyphosphatase; Provisional; Region: PRK10854 595496007479 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 595496007480 MASE1; Region: MASE1; pfam05231 595496007481 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 595496007482 diguanylate cyclase; Region: GGDEF; smart00267 595496007483 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 595496007484 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 595496007485 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 595496007486 GMP synthase; Reviewed; Region: guaA; PRK00074 595496007487 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 595496007488 AMP/PPi binding site [chemical binding]; other site 595496007489 candidate oxyanion hole; other site 595496007490 catalytic triad [active] 595496007491 potential glutamine specificity residues [chemical binding]; other site 595496007492 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 595496007493 ATP Binding subdomain [chemical binding]; other site 595496007494 Ligand Binding sites [chemical binding]; other site 595496007495 Dimerization subdomain; other site 595496007496 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 595496007497 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 595496007498 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 595496007499 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 595496007500 active site 595496007501 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 595496007502 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 595496007503 generic binding surface II; other site 595496007504 generic binding surface I; other site 595496007505 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 595496007506 GTP-binding protein Der; Reviewed; Region: PRK00093 595496007507 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 595496007508 G1 box; other site 595496007509 GTP/Mg2+ binding site [chemical binding]; other site 595496007510 Switch I region; other site 595496007511 G2 box; other site 595496007512 Switch II region; other site 595496007513 G3 box; other site 595496007514 G4 box; other site 595496007515 G5 box; other site 595496007516 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 595496007517 G1 box; other site 595496007518 GTP/Mg2+ binding site [chemical binding]; other site 595496007519 Switch I region; other site 595496007520 G2 box; other site 595496007521 G3 box; other site 595496007522 Switch II region; other site 595496007523 G4 box; other site 595496007524 G5 box; other site 595496007525 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 595496007526 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cd00216 595496007527 Trp docking motif [polypeptide binding]; other site 595496007528 active site 595496007529 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 595496007530 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 595496007531 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 595496007532 dimer interface [polypeptide binding]; other site 595496007533 motif 1; other site 595496007534 active site 595496007535 motif 2; other site 595496007536 motif 3; other site 595496007537 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 595496007538 anticodon binding site; other site 595496007539 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 595496007540 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 595496007541 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 595496007542 cytoskeletal protein RodZ; Provisional; Region: PRK10856 595496007543 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 595496007544 non-specific DNA binding site [nucleotide binding]; other site 595496007545 salt bridge; other site 595496007546 sequence-specific DNA binding site [nucleotide binding]; other site 595496007547 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 595496007548 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 595496007549 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 595496007550 FeS/SAM binding site; other site 595496007551 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 595496007552 active site 595496007553 multimer interface [polypeptide binding]; other site 595496007554 penicillin-binding protein 1C; Provisional; Region: PRK11240 595496007555 Transglycosylase; Region: Transgly; pfam00912 595496007556 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 595496007557 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 595496007558 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 595496007559 MG2 domain; Region: A2M_N; pfam01835 595496007560 Alpha-2-macroglobulin family; Region: A2M; pfam00207 595496007561 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 595496007562 surface patch; other site 595496007563 thioester region; other site 595496007564 specificity defining residues; other site 595496007565 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 595496007566 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 595496007567 active site residue [active] 595496007568 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 595496007569 active site residue [active] 595496007570 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 595496007571 aminopeptidase B; Provisional; Region: PRK05015 595496007572 Peptidase; Region: DUF3663; pfam12404 595496007573 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 595496007574 interface (dimer of trimers) [polypeptide binding]; other site 595496007575 Substrate-binding/catalytic site; other site 595496007576 Zn-binding sites [ion binding]; other site 595496007577 hypothetical protein; Provisional; Region: PRK10721 595496007578 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 595496007579 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 595496007580 catalytic loop [active] 595496007581 iron binding site [ion binding]; other site 595496007582 chaperone protein HscA; Provisional; Region: hscA; PRK05183 595496007583 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 595496007584 nucleotide binding site [chemical binding]; other site 595496007585 putative NEF/HSP70 interaction site [polypeptide binding]; other site 595496007586 SBD interface [polypeptide binding]; other site 595496007587 co-chaperone HscB; Provisional; Region: hscB; PRK05014 595496007588 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 595496007589 HSP70 interaction site [polypeptide binding]; other site 595496007590 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 595496007591 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 595496007592 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 595496007593 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 595496007594 trimerization site [polypeptide binding]; other site 595496007595 active site 595496007596 cysteine desulfurase; Provisional; Region: PRK14012 595496007597 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 595496007598 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 595496007599 catalytic residue [active] 595496007600 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 595496007601 Rrf2 family protein; Region: rrf2_super; TIGR00738 595496007602 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 595496007603 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 595496007604 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 595496007605 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 595496007606 active site 595496007607 dimerization interface [polypeptide binding]; other site 595496007608 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 595496007609 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 595496007610 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 595496007611 PRD domain; Region: PRD; pfam00874 595496007612 PRD domain; Region: PRD; pfam00874 595496007613 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 595496007614 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496007615 putative substrate translocation pore; other site 595496007616 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 595496007617 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496007618 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 595496007619 dimerization interface [polypeptide binding]; other site 595496007620 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 595496007621 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 595496007622 iron-sulfur cluster [ion binding]; other site 595496007623 [2Fe-2S] cluster binding site [ion binding]; other site 595496007624 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 595496007625 beta subunit interface [polypeptide binding]; other site 595496007626 alpha subunit interface [polypeptide binding]; other site 595496007627 active site 595496007628 substrate binding site [chemical binding]; other site 595496007629 Fe binding site [ion binding]; other site 595496007630 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 595496007631 inter-subunit interface; other site 595496007632 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 595496007633 [2Fe-2S] cluster binding site [ion binding]; other site 595496007634 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 595496007635 cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB)-like, classical (c) SDRs; Region: BphB-like_SDR_c; cd05348 595496007636 NAD binding site [chemical binding]; other site 595496007637 active site 595496007638 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 595496007639 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 595496007640 Predicted membrane protein [Function unknown]; Region: COG2259 595496007641 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 595496007642 active site 595496007643 catalytic residues [active] 595496007644 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 595496007645 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 595496007646 putative NAD(P) binding site [chemical binding]; other site 595496007647 catalytic Zn binding site [ion binding]; other site 595496007648 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 595496007649 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 595496007650 TM-ABC transporter signature motif; other site 595496007651 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 595496007652 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 595496007653 Walker A/P-loop; other site 595496007654 ATP binding site [chemical binding]; other site 595496007655 Q-loop/lid; other site 595496007656 ABC transporter signature motif; other site 595496007657 Walker B; other site 595496007658 D-loop; other site 595496007659 H-loop/switch region; other site 595496007660 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 595496007661 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 595496007662 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 595496007663 ligand binding site [chemical binding]; other site 595496007664 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 595496007665 TPR motif; other site 595496007666 Tetratricopeptide repeat; Region: TPR_16; pfam13432 595496007667 binding surface 595496007668 TPR repeat; Region: TPR_11; pfam13414 595496007669 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 595496007670 TPR motif; other site 595496007671 binding surface 595496007672 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 595496007673 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 595496007674 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 595496007675 nucleotide binding site [chemical binding]; other site 595496007676 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 595496007677 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 595496007678 dimer interface [polypeptide binding]; other site 595496007679 active site 595496007680 glycine-pyridoxal phosphate binding site [chemical binding]; other site 595496007681 folate binding site [chemical binding]; other site 595496007682 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 595496007683 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 595496007684 heme-binding site [chemical binding]; other site 595496007685 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 595496007686 FAD binding pocket [chemical binding]; other site 595496007687 FAD binding motif [chemical binding]; other site 595496007688 phosphate binding motif [ion binding]; other site 595496007689 beta-alpha-beta structure motif; other site 595496007690 NAD binding pocket [chemical binding]; other site 595496007691 Heme binding pocket [chemical binding]; other site 595496007692 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 595496007693 Nitrogen regulatory protein P-II; Region: P-II; smart00938 595496007694 response regulator GlrR; Provisional; Region: PRK15115 595496007695 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 595496007696 active site 595496007697 phosphorylation site [posttranslational modification] 595496007698 intermolecular recognition site; other site 595496007699 dimerization interface [polypeptide binding]; other site 595496007700 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 595496007701 Walker A motif; other site 595496007702 ATP binding site [chemical binding]; other site 595496007703 Walker B motif; other site 595496007704 arginine finger; other site 595496007705 hypothetical protein; Provisional; Region: PRK10722 595496007706 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 595496007707 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 595496007708 dimer interface [polypeptide binding]; other site 595496007709 phosphorylation site [posttranslational modification] 595496007710 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 595496007711 ATP binding site [chemical binding]; other site 595496007712 Mg2+ binding site [ion binding]; other site 595496007713 G-X-G motif; other site 595496007714 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 595496007715 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 595496007716 dimerization interface [polypeptide binding]; other site 595496007717 ATP binding site [chemical binding]; other site 595496007718 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 595496007719 dimerization interface [polypeptide binding]; other site 595496007720 ATP binding site [chemical binding]; other site 595496007721 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 595496007722 putative active site [active] 595496007723 catalytic triad [active] 595496007724 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 595496007725 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 595496007726 substrate binding pocket [chemical binding]; other site 595496007727 membrane-bound complex binding site; other site 595496007728 hinge residues; other site 595496007729 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 595496007730 N-acetyl-D-glucosamine binding site [chemical binding]; other site 595496007731 catalytic residue [active] 595496007732 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 595496007733 nucleoside/Zn binding site; other site 595496007734 dimer interface [polypeptide binding]; other site 595496007735 catalytic motif [active] 595496007736 hypothetical protein; Provisional; Region: PRK11590 595496007737 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 595496007738 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 595496007739 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 595496007740 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 595496007741 putative active site [active] 595496007742 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 595496007743 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 595496007744 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 595496007745 active site 595496007746 hydrophilic channel; other site 595496007747 dimerization interface [polypeptide binding]; other site 595496007748 catalytic residues [active] 595496007749 active site lid [active] 595496007750 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 595496007751 Recombination protein O N terminal; Region: RecO_N; pfam11967 595496007752 Recombination protein O C terminal; Region: RecO_C; pfam02565 595496007753 GTPase Era; Reviewed; Region: era; PRK00089 595496007754 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 595496007755 G1 box; other site 595496007756 GTP/Mg2+ binding site [chemical binding]; other site 595496007757 Switch I region; other site 595496007758 G2 box; other site 595496007759 Switch II region; other site 595496007760 G3 box; other site 595496007761 G4 box; other site 595496007762 G5 box; other site 595496007763 KH domain; Region: KH_2; pfam07650 595496007764 ribonuclease III; Reviewed; Region: rnc; PRK00102 595496007765 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 595496007766 dimerization interface [polypeptide binding]; other site 595496007767 active site 595496007768 metal binding site [ion binding]; metal-binding site 595496007769 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 595496007770 dsRNA binding site [nucleotide binding]; other site 595496007771 signal peptidase I; Provisional; Region: PRK10861 595496007772 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 595496007773 Catalytic site [active] 595496007774 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 595496007775 GTP-binding protein LepA; Provisional; Region: PRK05433 595496007776 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 595496007777 G1 box; other site 595496007778 putative GEF interaction site [polypeptide binding]; other site 595496007779 GTP/Mg2+ binding site [chemical binding]; other site 595496007780 Switch I region; other site 595496007781 G2 box; other site 595496007782 G3 box; other site 595496007783 Switch II region; other site 595496007784 G4 box; other site 595496007785 G5 box; other site 595496007786 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 595496007787 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 595496007788 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 595496007789 SoxR reducing system protein RseC; Provisional; Region: PRK10862 595496007790 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 595496007791 anti-sigma E factor; Provisional; Region: rseB; PRK09455 595496007792 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 595496007793 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 595496007794 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 595496007795 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 595496007796 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 595496007797 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 595496007798 DNA binding residues [nucleotide binding] 595496007799 L-aspartate oxidase; Provisional; Region: PRK09077 595496007800 L-aspartate oxidase; Provisional; Region: PRK06175 595496007801 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 595496007802 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 595496007803 Methyltransferase domain; Region: Methyltransf_26; pfam13659 595496007804 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 595496007805 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 595496007806 ATP binding site [chemical binding]; other site 595496007807 Mg++ binding site [ion binding]; other site 595496007808 motif III; other site 595496007809 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 595496007810 nucleotide binding region [chemical binding]; other site 595496007811 ATP-binding site [chemical binding]; other site 595496007812 Transcriptional regulator [Transcription]; Region: LysR; COG0583 595496007813 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496007814 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 595496007815 dimerization interface [polypeptide binding]; other site 595496007816 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 595496007817 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 595496007818 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 595496007819 ligand binding site [chemical binding]; other site 595496007820 active site 595496007821 UGI interface [polypeptide binding]; other site 595496007822 catalytic site [active] 595496007823 putative methyltransferase; Provisional; Region: PRK10864 595496007824 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 595496007825 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 595496007826 thioredoxin 2; Provisional; Region: PRK10996 595496007827 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 595496007828 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 595496007829 catalytic residues [active] 595496007830 Uncharacterized conserved protein [Function unknown]; Region: COG3148 595496007831 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 595496007832 CoA binding domain; Region: CoA_binding_2; pfam13380 595496007833 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 595496007834 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 595496007835 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 595496007836 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 595496007837 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 595496007838 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 595496007839 domain interface [polypeptide binding]; other site 595496007840 putative active site [active] 595496007841 catalytic site [active] 595496007842 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 595496007843 domain interface [polypeptide binding]; other site 595496007844 putative active site [active] 595496007845 catalytic site [active] 595496007846 lipoprotein; Provisional; Region: PRK10759 595496007847 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 595496007848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496007849 putative substrate translocation pore; other site 595496007850 protein disaggregation chaperone; Provisional; Region: PRK10865 595496007851 Clp amino terminal domain; Region: Clp_N; pfam02861 595496007852 Clp amino terminal domain; Region: Clp_N; pfam02861 595496007853 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 595496007854 Walker A motif; other site 595496007855 ATP binding site [chemical binding]; other site 595496007856 Walker B motif; other site 595496007857 arginine finger; other site 595496007858 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 595496007859 Walker A motif; other site 595496007860 ATP binding site [chemical binding]; other site 595496007861 Walker B motif; other site 595496007862 arginine finger; other site 595496007863 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 595496007864 hypothetical protein; Provisional; Region: PRK10723 595496007865 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 595496007866 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 595496007867 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 595496007868 RNA binding surface [nucleotide binding]; other site 595496007869 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 595496007870 active site 595496007871 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 595496007872 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 595496007873 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 595496007874 30S subunit binding site; other site 595496007875 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 595496007876 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 595496007877 Prephenate dehydratase; Region: PDT; pfam00800 595496007878 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 595496007879 putative L-Phe binding site [chemical binding]; other site 595496007880 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 595496007881 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 595496007882 prephenate dehydrogenase; Validated; Region: PRK08507 595496007883 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 595496007884 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 595496007885 lipoprotein; Provisional; Region: PRK11443 595496007886 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 595496007887 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 595496007888 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 595496007889 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 595496007890 metal binding site [ion binding]; metal-binding site 595496007891 active site 595496007892 I-site; other site 595496007893 putative outer membrane lipoprotein; Provisional; Region: PRK09967 595496007894 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 595496007895 ligand binding site [chemical binding]; other site 595496007896 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 595496007897 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 595496007898 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 595496007899 RimM N-terminal domain; Region: RimM; pfam01782 595496007900 PRC-barrel domain; Region: PRC; pfam05239 595496007901 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 595496007902 signal recognition particle protein; Provisional; Region: PRK10867 595496007903 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 595496007904 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 595496007905 P loop; other site 595496007906 GTP binding site [chemical binding]; other site 595496007907 Signal peptide binding domain; Region: SRP_SPB; pfam02978 595496007908 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 595496007909 hypothetical protein; Provisional; Region: PRK11573 595496007910 Domain of unknown function DUF21; Region: DUF21; pfam01595 595496007911 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 595496007912 Transporter associated domain; Region: CorC_HlyC; smart01091 595496007913 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 595496007914 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 595496007915 dimer interface [polypeptide binding]; other site 595496007916 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 595496007917 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 595496007918 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 595496007919 recombination and repair protein; Provisional; Region: PRK10869 595496007920 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 595496007921 Walker A/P-loop; other site 595496007922 ATP binding site [chemical binding]; other site 595496007923 Q-loop/lid; other site 595496007924 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 595496007925 Q-loop/lid; other site 595496007926 ABC transporter signature motif; other site 595496007927 Walker B; other site 595496007928 D-loop; other site 595496007929 H-loop/switch region; other site 595496007930 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 595496007931 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 595496007932 hypothetical protein; Validated; Region: PRK01777 595496007933 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 595496007934 putative coenzyme Q binding site [chemical binding]; other site 595496007935 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 595496007936 SmpB-tmRNA interface; other site 595496007937 integrase; Provisional; Region: PRK09692 595496007938 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 595496007939 active site 595496007940 Int/Topo IB signature motif; other site 595496007941 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 595496007942 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 595496007943 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 595496007944 Superfamily II helicase [General function prediction only]; Region: COG1204 595496007945 DEAD/DEAH box helicase; Region: DEAD; pfam00270 595496007946 helicase superfamily c-terminal domain; Region: HELICc; smart00490 595496007947 nucleotide binding region [chemical binding]; other site 595496007948 ATP-binding site [chemical binding]; other site 595496007949 Domain of unknown function (DUF4297); Region: DUF4297; pfam14130 595496007950 Domain of unknown function (DUF1837); Region: DUF1837; pfam08878 595496007951 Predicted GTPase [General function prediction only]; Region: COG3596 595496007952 YfjP GTPase; Region: YfjP; cd11383 595496007953 G1 box; other site 595496007954 GTP/Mg2+ binding site [chemical binding]; other site 595496007955 Switch I region; other site 595496007956 G2 box; other site 595496007957 Switch II region; other site 595496007958 G3 box; other site 595496007959 G4 box; other site 595496007960 G5 box; other site 595496007961 Domain of unknown function (DUF932); Region: DUF932; pfam06067 595496007962 Predicted transcriptional regulator [Transcription]; Region: COG2378 595496007963 HTH domain; Region: HTH_11; cl17392 595496007964 WYL domain; Region: WYL; pfam13280 595496007965 Predicted transcriptional regulator [Transcription]; Region: COG2378 595496007966 Antirestriction protein; Region: Antirestrict; pfam03230 595496007967 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 595496007968 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 595496007969 MPN+ (JAMM) motif; other site 595496007970 Zinc-binding site [ion binding]; other site 595496007971 Protein of unknown function (DUF987); Region: DUF987; pfam06174 595496007972 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 595496007973 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 595496007974 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 595496007975 hypothetical protein; Provisional; Region: PRK09945 595496007976 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 595496007977 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 595496007978 Autotransporter beta-domain; Region: Autotransporter; pfam03797 595496007979 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 595496007980 substrate binding pocket [chemical binding]; other site 595496007981 active site 595496007982 iron coordination sites [ion binding]; other site 595496007983 Predicted dehydrogenase [General function prediction only]; Region: COG0579 595496007984 hydroxyglutarate oxidase; Provisional; Region: PRK11728 595496007985 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 595496007986 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 595496007987 tetramerization interface [polypeptide binding]; other site 595496007988 NAD(P) binding site [chemical binding]; other site 595496007989 catalytic residues [active] 595496007990 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 595496007991 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 595496007992 inhibitor-cofactor binding pocket; inhibition site 595496007993 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496007994 catalytic residue [active] 595496007995 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 595496007996 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 595496007997 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 595496007998 DNA-binding site [nucleotide binding]; DNA binding site 595496007999 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 595496008000 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 595496008001 bacterial OsmY and nodulation domain; Region: BON; smart00749 595496008002 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 595496008003 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 595496008004 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 595496008005 dimerization interface [polypeptide binding]; other site 595496008006 putative DNA binding site [nucleotide binding]; other site 595496008007 Transcriptional regulators [Transcription]; Region: MarR; COG1846 595496008008 putative Zn2+ binding site [ion binding]; other site 595496008009 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527 595496008010 active site residue [active] 595496008011 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 595496008012 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 595496008013 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 595496008014 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 595496008015 hypothetical protein; Provisional; Region: PRK10556 595496008016 hypothetical protein; Provisional; Region: PRK10132 595496008017 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 595496008018 catalytic residues [active] 595496008019 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 595496008020 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 595496008021 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 595496008022 Class I ribonucleotide reductase; Region: RNR_I; cd01679 595496008023 active site 595496008024 dimer interface [polypeptide binding]; other site 595496008025 catalytic residues [active] 595496008026 effector binding site; other site 595496008027 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 595496008028 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 595496008029 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 595496008030 dimer interface [polypeptide binding]; other site 595496008031 putative radical transfer pathway; other site 595496008032 diiron center [ion binding]; other site 595496008033 tyrosyl radical; other site 595496008034 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 595496008035 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 595496008036 Walker A/P-loop; other site 595496008037 ATP binding site [chemical binding]; other site 595496008038 Q-loop/lid; other site 595496008039 ABC transporter signature motif; other site 595496008040 Walker B; other site 595496008041 D-loop; other site 595496008042 H-loop/switch region; other site 595496008043 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 595496008044 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 595496008045 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496008046 dimer interface [polypeptide binding]; other site 595496008047 conserved gate region; other site 595496008048 putative PBP binding loops; other site 595496008049 ABC-ATPase subunit interface; other site 595496008050 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 595496008051 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 595496008052 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 595496008053 putative L-valine exporter; Provisional; Region: PRK10408 595496008054 transcriptional repressor MprA; Provisional; Region: PRK10870 595496008055 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 595496008056 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 595496008057 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 595496008058 HlyD family secretion protein; Region: HlyD_3; pfam13437 595496008059 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 595496008060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496008061 putative substrate translocation pore; other site 595496008062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496008063 S-ribosylhomocysteinase; Provisional; Region: PRK02260 595496008064 glutamate--cysteine ligase; Provisional; Region: PRK02107 595496008065 Predicted membrane protein [Function unknown]; Region: COG1238 595496008066 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 595496008067 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 595496008068 motif II; other site 595496008069 carbon storage regulator; Provisional; Region: PRK01712 595496008070 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 595496008071 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 595496008072 motif 1; other site 595496008073 active site 595496008074 motif 2; other site 595496008075 motif 3; other site 595496008076 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 595496008077 DHHA1 domain; Region: DHHA1; pfam02272 595496008078 recombination regulator RecX; Reviewed; Region: recX; PRK00117 595496008079 recombinase A; Provisional; Region: recA; PRK09354 595496008080 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 595496008081 hexamer interface [polypeptide binding]; other site 595496008082 Walker A motif; other site 595496008083 ATP binding site [chemical binding]; other site 595496008084 Walker B motif; other site 595496008085 hypothetical protein; Validated; Region: PRK03661 595496008086 Transglycosylase SLT domain; Region: SLT_2; pfam13406 595496008087 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 595496008088 N-acetyl-D-glucosamine binding site [chemical binding]; other site 595496008089 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 595496008090 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 595496008091 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 595496008092 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 595496008093 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 595496008094 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 595496008095 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 595496008096 putative NAD(P) binding site [chemical binding]; other site 595496008097 active site 595496008098 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 595496008099 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 595496008100 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 595496008101 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 595496008102 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 595496008103 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 595496008104 putative active site [active] 595496008105 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 595496008106 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 595496008107 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 595496008108 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 595496008109 Walker A motif; other site 595496008110 ATP binding site [chemical binding]; other site 595496008111 Walker B motif; other site 595496008112 arginine finger; other site 595496008113 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 595496008114 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 595496008115 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 595496008116 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 595496008117 iron binding site [ion binding]; other site 595496008118 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 595496008119 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 595496008120 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 595496008121 Acylphosphatase; Region: Acylphosphatase; pfam00708 595496008122 HypF finger; Region: zf-HYPF; pfam07503 595496008123 HypF finger; Region: zf-HYPF; pfam07503 595496008124 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 595496008125 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 595496008126 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 595496008127 Transcriptional regulators [Transcription]; Region: PurR; COG1609 595496008128 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 595496008129 DNA binding site [nucleotide binding] 595496008130 domain linker motif; other site 595496008131 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 595496008132 dimerization interface (closed form) [polypeptide binding]; other site 595496008133 ligand binding site [chemical binding]; other site 595496008134 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 595496008135 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 595496008136 active site turn [active] 595496008137 phosphorylation site [posttranslational modification] 595496008138 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 595496008139 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 595496008140 beta-galactosidase; Region: BGL; TIGR03356 595496008141 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 595496008142 nickel binding site [ion binding]; other site 595496008143 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 595496008144 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 595496008145 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 595496008146 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 595496008147 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 595496008148 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 595496008149 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 595496008150 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 595496008151 NADH dehydrogenase; Region: NADHdh; cl00469 595496008152 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 595496008153 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 595496008154 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 595496008155 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 595496008156 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 595496008157 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 595496008158 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 595496008159 hydrogenase assembly chaperone; Provisional; Region: PRK10409 595496008160 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 595496008161 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 595496008162 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 595496008163 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 595496008164 dimerization interface [polypeptide binding]; other site 595496008165 ATP binding site [chemical binding]; other site 595496008166 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 595496008167 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 595496008168 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 595496008169 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 595496008170 Walker A motif; other site 595496008171 ATP binding site [chemical binding]; other site 595496008172 Walker B motif; other site 595496008173 arginine finger; other site 595496008174 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 595496008175 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 595496008176 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 595496008177 MutS domain I; Region: MutS_I; pfam01624 595496008178 MutS domain II; Region: MutS_II; pfam05188 595496008179 MutS domain III; Region: MutS_III; pfam05192 595496008180 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 595496008181 Walker A/P-loop; other site 595496008182 ATP binding site [chemical binding]; other site 595496008183 Q-loop/lid; other site 595496008184 ABC transporter signature motif; other site 595496008185 Walker B; other site 595496008186 D-loop; other site 595496008187 H-loop/switch region; other site 595496008188 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 595496008189 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 595496008190 active site 595496008191 metal binding site [ion binding]; metal-binding site 595496008192 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 595496008193 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 595496008194 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 595496008195 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 595496008196 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 595496008197 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 595496008198 putative aldolase; Validated; Region: PRK08130 595496008199 active site 595496008200 intersubunit interface [polypeptide binding]; other site 595496008201 Zn2+ binding site [ion binding]; other site 595496008202 hypothetical protein; Provisional; Region: PRK09989 595496008203 putative transporter; Provisional; Region: PRK09821 595496008204 GntP family permease; Region: GntP_permease; pfam02447 595496008205 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 595496008206 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 595496008207 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 595496008208 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 595496008209 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 595496008210 DNA binding residues [nucleotide binding] 595496008211 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 595496008212 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 595496008213 Peptidase family M23; Region: Peptidase_M23; pfam01551 595496008214 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 595496008215 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 595496008216 S-adenosylmethionine binding site [chemical binding]; other site 595496008217 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 595496008218 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 595496008219 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 595496008220 Permutation of conserved domain; other site 595496008221 active site 595496008222 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 595496008223 homotrimer interaction site [polypeptide binding]; other site 595496008224 zinc binding site [ion binding]; other site 595496008225 CDP-binding sites; other site 595496008226 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 595496008227 substrate binding site; other site 595496008228 dimer interface; other site 595496008229 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 595496008230 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 595496008231 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 595496008232 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 595496008233 ligand-binding site [chemical binding]; other site 595496008234 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 595496008235 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 595496008236 CysD dimerization site [polypeptide binding]; other site 595496008237 G1 box; other site 595496008238 putative GEF interaction site [polypeptide binding]; other site 595496008239 GTP/Mg2+ binding site [chemical binding]; other site 595496008240 Switch I region; other site 595496008241 G2 box; other site 595496008242 G3 box; other site 595496008243 Switch II region; other site 595496008244 G4 box; other site 595496008245 G5 box; other site 595496008246 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 595496008247 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 595496008248 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 595496008249 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 595496008250 Active Sites [active] 595496008251 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 595496008252 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 595496008253 metal binding site [ion binding]; metal-binding site 595496008254 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 595496008255 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 595496008256 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09664 595496008257 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 595496008258 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 595496008259 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646 595496008260 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09670 595496008261 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 595496008262 helicase Cas3; Provisional; Region: PRK09694 595496008263 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 595496008264 CRISPR/Cas system-associated protein Cas3; Region: Cas3_I; cd09639 595496008265 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 595496008266 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 595496008267 Active Sites [active] 595496008268 sulfite reductase subunit beta; Provisional; Region: PRK13504 595496008269 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 595496008270 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 595496008271 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 595496008272 Flavodoxin; Region: Flavodoxin_1; pfam00258 595496008273 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 595496008274 FAD binding pocket [chemical binding]; other site 595496008275 FAD binding motif [chemical binding]; other site 595496008276 catalytic residues [active] 595496008277 NAD binding pocket [chemical binding]; other site 595496008278 phosphate binding motif [ion binding]; other site 595496008279 beta-alpha-beta structure motif; other site 595496008280 6-pyruvoyl tetrahydropterin synthase (PTPS). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a...; Region: PTPS; cd00470 595496008281 homohexamer interface [polypeptide binding]; other site 595496008282 putative substrate stabilizing pore; other site 595496008283 pterin binding site; other site 595496008284 putative oxidoreductase FixC; Provisional; Region: PRK10157 595496008285 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 595496008286 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 595496008287 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 595496008288 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 595496008289 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 595496008290 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 595496008291 Ligand binding site [chemical binding]; other site 595496008292 Electron transfer flavoprotein domain; Region: ETF; pfam01012 595496008293 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 595496008294 benzoate transport; Region: 2A0115; TIGR00895 595496008295 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496008296 putative substrate translocation pore; other site 595496008297 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 595496008298 FAD binding domain; Region: FAD_binding_4; pfam01565 595496008299 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 595496008300 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 595496008301 NADP binding site [chemical binding]; other site 595496008302 homodimer interface [polypeptide binding]; other site 595496008303 active site 595496008304 Major Facilitator Superfamily; Region: MFS_1; pfam07690 595496008305 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496008306 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 595496008307 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 595496008308 nucleotide binding site [chemical binding]; other site 595496008309 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 595496008310 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 595496008311 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 595496008312 Repair protein; Region: Repair_PSII; pfam04536 595496008313 enolase; Provisional; Region: eno; PRK00077 595496008314 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 595496008315 dimer interface [polypeptide binding]; other site 595496008316 metal binding site [ion binding]; metal-binding site 595496008317 substrate binding pocket [chemical binding]; other site 595496008318 CTP synthetase; Validated; Region: pyrG; PRK05380 595496008319 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 595496008320 Catalytic site [active] 595496008321 active site 595496008322 UTP binding site [chemical binding]; other site 595496008323 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 595496008324 active site 595496008325 putative oxyanion hole; other site 595496008326 catalytic triad [active] 595496008327 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 595496008328 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 595496008329 homodimer interface [polypeptide binding]; other site 595496008330 metal binding site [ion binding]; metal-binding site 595496008331 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 595496008332 homodimer interface [polypeptide binding]; other site 595496008333 active site 595496008334 putative chemical substrate binding site [chemical binding]; other site 595496008335 metal binding site [ion binding]; metal-binding site 595496008336 toxin MazF; Provisional; Region: PRK09907 595496008337 antitoxin MazE; Provisional; Region: PRK09798 595496008338 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 595496008339 HD domain; Region: HD_4; pfam13328 595496008340 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 595496008341 synthetase active site [active] 595496008342 NTP binding site [chemical binding]; other site 595496008343 metal binding site [ion binding]; metal-binding site 595496008344 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 595496008345 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 595496008346 IS2 transposase TnpB; Reviewed; Region: PRK09409 595496008347 HTH-like domain; Region: HTH_21; pfam13276 595496008348 Integrase core domain; Region: rve; pfam00665 595496008349 Integrase core domain; Region: rve_3; pfam13683 595496008350 IS2 repressor TnpA; Reviewed; Region: PRK09413 595496008351 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 595496008352 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 595496008353 TRAM domain; Region: TRAM; pfam01938 595496008354 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 595496008355 S-adenosylmethionine binding site [chemical binding]; other site 595496008356 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 595496008357 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 595496008358 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 595496008359 dimerization interface [polypeptide binding]; other site 595496008360 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 595496008361 dimer interface [polypeptide binding]; other site 595496008362 phosphorylation site [posttranslational modification] 595496008363 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 595496008364 ATP binding site [chemical binding]; other site 595496008365 Mg2+ binding site [ion binding]; other site 595496008366 G-X-G motif; other site 595496008367 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 595496008368 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 595496008369 active site 595496008370 phosphorylation site [posttranslational modification] 595496008371 intermolecular recognition site; other site 595496008372 dimerization interface [polypeptide binding]; other site 595496008373 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 595496008374 putative binding surface; other site 595496008375 active site 595496008376 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 595496008377 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 595496008378 active site 595496008379 tetramer interface [polypeptide binding]; other site 595496008380 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 595496008381 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 595496008382 active site 595496008383 tetramer interface [polypeptide binding]; other site 595496008384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496008385 D-galactonate transporter; Region: 2A0114; TIGR00893 595496008386 putative substrate translocation pore; other site 595496008387 flavodoxin; Provisional; Region: PRK08105 595496008388 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 595496008389 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 595496008390 probable active site [active] 595496008391 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 595496008392 SecY interacting protein Syd; Provisional; Region: PRK04968 595496008393 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 595496008394 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 595496008395 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 595496008396 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 595496008397 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 595496008398 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 595496008399 serine transporter; Region: stp; TIGR00814 595496008400 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 595496008401 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 595496008402 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 595496008403 flap endonuclease-like protein; Provisional; Region: PRK09482 595496008404 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 595496008405 active site 595496008406 metal binding site 1 [ion binding]; metal-binding site 595496008407 putative 5' ssDNA interaction site; other site 595496008408 metal binding site 3; metal-binding site 595496008409 metal binding site 2 [ion binding]; metal-binding site 595496008410 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 595496008411 putative DNA binding site [nucleotide binding]; other site 595496008412 putative metal binding site [ion binding]; other site 595496008413 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 595496008414 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 595496008415 dimer interface [polypeptide binding]; other site 595496008416 active site 595496008417 metal binding site [ion binding]; metal-binding site 595496008418 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 595496008419 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 595496008420 intersubunit interface [polypeptide binding]; other site 595496008421 active site 595496008422 Zn2+ binding site [ion binding]; other site 595496008423 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 595496008424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496008425 putative substrate translocation pore; other site 595496008426 L-fucose isomerase; Provisional; Region: fucI; PRK10991 595496008427 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 595496008428 hexamer (dimer of trimers) interface [polypeptide binding]; other site 595496008429 trimer interface [polypeptide binding]; other site 595496008430 substrate binding site [chemical binding]; other site 595496008431 Mn binding site [ion binding]; other site 595496008432 L-fuculokinase; Provisional; Region: PRK10331 595496008433 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 595496008434 nucleotide binding site [chemical binding]; other site 595496008435 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 595496008436 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 595496008437 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 595496008438 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 595496008439 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 595496008440 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 595496008441 hypothetical protein; Provisional; Region: PRK10873 595496008442 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 595496008443 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496008444 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 595496008445 dimerization interface [polypeptide binding]; other site 595496008446 substrate binding pocket [chemical binding]; other site 595496008447 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 595496008448 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 595496008449 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 595496008450 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 595496008451 catalytic residue [active] 595496008452 CsdA-binding activator; Provisional; Region: PRK15019 595496008453 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 595496008454 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 595496008455 putative ATP binding site [chemical binding]; other site 595496008456 putative substrate interface [chemical binding]; other site 595496008457 murein transglycosylase A; Provisional; Region: mltA; PRK11162 595496008458 MltA specific insert domain; Region: MltA; pfam03562 595496008459 3D domain; Region: 3D; pfam06725 595496008460 AMIN domain; Region: AMIN; pfam11741 595496008461 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 595496008462 active site 595496008463 metal binding site [ion binding]; metal-binding site 595496008464 N-acetylglutamate synthase; Validated; Region: PRK05279 595496008465 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 595496008466 putative feedback inhibition sensing region; other site 595496008467 putative nucleotide binding site [chemical binding]; other site 595496008468 putative substrate binding site [chemical binding]; other site 595496008469 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 595496008470 Coenzyme A binding pocket [chemical binding]; other site 595496008471 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 595496008472 AAA domain; Region: AAA_30; pfam13604 595496008473 Family description; Region: UvrD_C_2; pfam13538 595496008474 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 595496008475 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 595496008476 protease3; Provisional; Region: PRK15101 595496008477 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 595496008478 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 595496008479 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 595496008480 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 595496008481 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 595496008482 hypothetical protein; Provisional; Region: PRK10332 595496008483 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 595496008484 hypothetical protein; Provisional; Region: PRK11521 595496008485 hypothetical protein; Provisional; Region: PRK10557 595496008486 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 595496008487 hypothetical protein; Provisional; Region: PRK10506 595496008488 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 595496008489 thymidylate synthase; Reviewed; Region: thyA; PRK01827 595496008490 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 595496008491 dimerization interface [polypeptide binding]; other site 595496008492 active site 595496008493 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 595496008494 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 595496008495 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 595496008496 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 595496008497 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 595496008498 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 595496008499 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 595496008500 putative active site [active] 595496008501 Ap4A binding site [chemical binding]; other site 595496008502 nudix motif; other site 595496008503 putative metal binding site [ion binding]; other site 595496008504 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 595496008505 putative DNA-binding cleft [nucleotide binding]; other site 595496008506 putative DNA clevage site; other site 595496008507 molecular lever; other site 595496008508 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 595496008509 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 595496008510 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 595496008511 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 595496008512 active site 595496008513 catalytic tetrad [active] 595496008514 lysophospholipid transporter LplT; Provisional; Region: PRK11195 595496008515 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496008516 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 595496008517 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 595496008518 putative acyl-acceptor binding pocket; other site 595496008519 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 595496008520 acyl-activating enzyme (AAE) consensus motif; other site 595496008521 putative AMP binding site [chemical binding]; other site 595496008522 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 595496008523 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 595496008524 DNA binding site [nucleotide binding] 595496008525 domain linker motif; other site 595496008526 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 595496008527 dimerization interface (closed form) [polypeptide binding]; other site 595496008528 ligand binding site [chemical binding]; other site 595496008529 diaminopimelate decarboxylase; Provisional; Region: PRK11165 595496008530 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 595496008531 active site 595496008532 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 595496008533 substrate binding site [chemical binding]; other site 595496008534 catalytic residues [active] 595496008535 dimer interface [polypeptide binding]; other site 595496008536 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 595496008537 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496008538 The C-terminal substrate binding domain of LysR, transcriptional regulator for lysine biosynthesis, contains the type 2 periplasmic binding fold; Region: PBP2_LysR; cd08456 595496008539 putative dimerization interface [polypeptide binding]; other site 595496008540 putative racemase; Provisional; Region: PRK10200 595496008541 aspartate racemase; Region: asp_race; TIGR00035 595496008542 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 595496008543 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496008544 putative substrate translocation pore; other site 595496008545 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496008546 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 595496008547 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 595496008548 NADP binding site [chemical binding]; other site 595496008549 homodimer interface [polypeptide binding]; other site 595496008550 active site 595496008551 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 595496008552 putative acyltransferase; Provisional; Region: PRK05790 595496008553 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 595496008554 dimer interface [polypeptide binding]; other site 595496008555 active site 595496008556 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 595496008557 serine transporter; Region: stp; TIGR00814 595496008558 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 595496008559 DNA binding residues [nucleotide binding] 595496008560 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 595496008561 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 595496008562 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 595496008563 Tetratricopeptide repeat; Region: TPR_3; pfam07720 595496008564 Tetratricopeptide repeat; Region: TPR_3; pfam07720 595496008565 transcriptional regulator; Provisional; Region: PRK11906 595496008566 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 595496008567 DNA binding site [nucleotide binding] 595496008568 Tetratricopeptide repeat; Region: TPR_2; pfam07719 595496008569 IS2 transposase TnpB; Reviewed; Region: PRK09409 595496008570 HTH-like domain; Region: HTH_21; pfam13276 595496008571 Integrase core domain; Region: rve; pfam00665 595496008572 Integrase core domain; Region: rve_3; pfam13683 595496008573 IS2 repressor TnpA; Reviewed; Region: PRK09413 595496008574 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 595496008575 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 595496008576 Peptidase family M23; Region: Peptidase_M23; pfam01551 595496008577 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 595496008578 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 595496008579 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 595496008580 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 595496008581 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 595496008582 xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908 595496008583 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 595496008584 catalytic loop [active] 595496008585 iron binding site [ion binding]; other site 595496008586 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 595496008587 GAF domain; Region: GAF; cl17456 595496008588 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 595496008589 PAS domain; Region: PAS; smart00091 595496008590 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 595496008591 Walker A motif; other site 595496008592 ATP binding site [chemical binding]; other site 595496008593 Walker B motif; other site 595496008594 arginine finger; other site 595496008595 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 595496008596 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 595496008597 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 595496008598 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 595496008599 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 595496008600 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 595496008601 catalytic residue [active] 595496008602 peptidase; Reviewed; Region: PRK13004 595496008603 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 595496008604 putative metal binding site [ion binding]; other site 595496008605 putative dimer interface [polypeptide binding]; other site 595496008606 D-hydantoinase; Region: D-hydantoinase; TIGR02033 595496008607 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 595496008608 tetramer interface [polypeptide binding]; other site 595496008609 active site 595496008610 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 595496008611 carbamate kinase; Reviewed; Region: PRK12686 595496008612 putative substrate binding site [chemical binding]; other site 595496008613 homodimer interface [polypeptide binding]; other site 595496008614 nucleotide binding site [chemical binding]; other site 595496008615 nucleotide binding site [chemical binding]; other site 595496008616 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 595496008617 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 595496008618 XdhC Rossmann domain; Region: XdhC_C; pfam13478 595496008619 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 595496008620 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 595496008621 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 595496008622 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 595496008623 Ligand binding site; other site 595496008624 metal-binding site 595496008625 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 595496008626 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 595496008627 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 595496008628 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 595496008629 putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314 595496008630 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 595496008631 active site 595496008632 putative substrate binding pocket [chemical binding]; other site 595496008633 probable selenate reductase, FAD-binding subunit; Region: Se_sel_red_FAD; TIGR03312 595496008634 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 595496008635 putative hypoxanthine oxidase; Provisional; Region: PRK09800 595496008636 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 595496008637 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 595496008638 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 595496008639 uracil-xanthine permease; Region: ncs2; TIGR00801 595496008640 guanine deaminase; Provisional; Region: PRK09228 595496008641 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 595496008642 active site 595496008643 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 595496008644 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 595496008645 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12809 595496008646 4Fe-4S binding domain; Region: Fer4; pfam00037 595496008647 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 595496008648 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 595496008649 xanthine permease; Region: pbuX; TIGR03173 595496008650 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 595496008651 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 595496008652 active site 595496008653 metal binding site [ion binding]; metal-binding site 595496008654 nudix motif; other site 595496008655 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 595496008656 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 595496008657 dimer interface [polypeptide binding]; other site 595496008658 putative anticodon binding site; other site 595496008659 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 595496008660 motif 1; other site 595496008661 active site 595496008662 motif 2; other site 595496008663 motif 3; other site 595496008664 peptide chain release factor 2; Validated; Region: prfB; PRK00578 595496008665 This domain is found in peptide chain release factors; Region: PCRF; smart00937 595496008666 RF-1 domain; Region: RF-1; pfam00472 595496008667 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 595496008668 DHH family; Region: DHH; pfam01368 595496008669 DHHA1 domain; Region: DHHA1; pfam02272 595496008670 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 595496008671 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 595496008672 dimerization domain [polypeptide binding]; other site 595496008673 dimer interface [polypeptide binding]; other site 595496008674 catalytic residues [active] 595496008675 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 595496008676 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 595496008677 active site 595496008678 Int/Topo IB signature motif; other site 595496008679 flavodoxin FldB; Provisional; Region: PRK12359 595496008680 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 595496008681 hypothetical protein; Provisional; Region: PRK10878 595496008682 putative global regulator; Reviewed; Region: PRK09559 595496008683 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 595496008684 hemolysin; Provisional; Region: PRK15087 595496008685 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 595496008686 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 595496008687 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 595496008688 beta-galactosidase; Region: BGL; TIGR03356 595496008689 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 595496008690 classical (c) SDRs; Region: SDR_c; cd05233 595496008691 NAD(P) binding site [chemical binding]; other site 595496008692 active site 595496008693 glycine dehydrogenase; Provisional; Region: PRK05367 595496008694 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 595496008695 tetramer interface [polypeptide binding]; other site 595496008696 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496008697 catalytic residue [active] 595496008698 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 595496008699 tetramer interface [polypeptide binding]; other site 595496008700 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496008701 catalytic residue [active] 595496008702 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 595496008703 lipoyl attachment site [posttranslational modification]; other site 595496008704 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 595496008705 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 595496008706 oxidoreductase; Provisional; Region: PRK08013 595496008707 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 595496008708 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 595496008709 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 595496008710 proline aminopeptidase P II; Provisional; Region: PRK10879 595496008711 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 595496008712 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 595496008713 active site 595496008714 hypothetical protein; Reviewed; Region: PRK01736 595496008715 Z-ring-associated protein; Provisional; Region: PRK10972 595496008716 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 595496008717 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 595496008718 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 595496008719 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 595496008720 ligand binding site [chemical binding]; other site 595496008721 NAD binding site [chemical binding]; other site 595496008722 tetramer interface [polypeptide binding]; other site 595496008723 catalytic site [active] 595496008724 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 595496008725 L-serine binding site [chemical binding]; other site 595496008726 ACT domain interface; other site 595496008727 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 595496008728 tetramer (dimer of dimers) interface [polypeptide binding]; other site 595496008729 active site 595496008730 dimer interface [polypeptide binding]; other site 595496008731 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 595496008732 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496008733 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 595496008734 putative dimerization interface [polypeptide binding]; other site 595496008735 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 595496008736 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 595496008737 active site 595496008738 substrate binding site [chemical binding]; other site 595496008739 coenzyme B12 binding site [chemical binding]; other site 595496008740 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 595496008741 B12 binding site [chemical binding]; other site 595496008742 cobalt ligand [ion binding]; other site 595496008743 membrane ATPase/protein kinase; Provisional; Region: PRK09435 595496008744 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 595496008745 Walker A; other site 595496008746 methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423 595496008747 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 595496008748 substrate binding site [chemical binding]; other site 595496008749 oxyanion hole (OAH) forming residues; other site 595496008750 trimer interface [polypeptide binding]; other site 595496008751 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 595496008752 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 595496008753 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 595496008754 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496008755 Transcriptional regulator [Transcription]; Region: LysR; COG0583 595496008756 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 595496008757 dimerization interface [polypeptide binding]; other site 595496008758 Uncharacterized conserved protein [Function unknown]; Region: COG2968 595496008759 oxidative stress defense protein; Provisional; Region: PRK11087 595496008760 arginine exporter protein; Provisional; Region: PRK09304 595496008761 mechanosensitive channel MscS; Provisional; Region: PRK10334 595496008762 Mechanosensitive ion channel; Region: MS_channel; pfam00924 595496008763 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 595496008764 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 595496008765 active site 595496008766 intersubunit interface [polypeptide binding]; other site 595496008767 zinc binding site [ion binding]; other site 595496008768 Na+ binding site [ion binding]; other site 595496008769 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 595496008770 Phosphoglycerate kinase; Region: PGK; pfam00162 595496008771 substrate binding site [chemical binding]; other site 595496008772 hinge regions; other site 595496008773 ADP binding site [chemical binding]; other site 595496008774 catalytic site [active] 595496008775 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 595496008776 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 595496008777 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 595496008778 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 595496008779 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 595496008780 active site 595496008781 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 595496008782 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 595496008783 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 595496008784 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 595496008785 putative active site [active] 595496008786 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 595496008787 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 595496008788 putative NAD(P) binding site [chemical binding]; other site 595496008789 catalytic Zn binding site [ion binding]; other site 595496008790 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 595496008791 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 595496008792 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 595496008793 active site 595496008794 P-loop; other site 595496008795 phosphorylation site [posttranslational modification] 595496008796 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 595496008797 active site 595496008798 phosphorylation site [posttranslational modification] 595496008799 transketolase; Reviewed; Region: PRK12753 595496008800 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 595496008801 TPP-binding site [chemical binding]; other site 595496008802 dimer interface [polypeptide binding]; other site 595496008803 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 595496008804 PYR/PP interface [polypeptide binding]; other site 595496008805 dimer interface [polypeptide binding]; other site 595496008806 TPP binding site [chemical binding]; other site 595496008807 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 595496008808 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 595496008809 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 595496008810 agmatinase; Region: agmatinase; TIGR01230 595496008811 oligomer interface [polypeptide binding]; other site 595496008812 putative active site [active] 595496008813 Mn binding site [ion binding]; other site 595496008814 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 595496008815 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 595496008816 dimer interface [polypeptide binding]; other site 595496008817 active site 595496008818 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 595496008819 catalytic residues [active] 595496008820 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 595496008821 Virulence promoting factor; Region: YqgB; pfam11036 595496008822 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 595496008823 S-adenosylmethionine synthetase; Validated; Region: PRK05250 595496008824 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 595496008825 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 595496008826 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 595496008827 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 595496008828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496008829 putative substrate translocation pore; other site 595496008830 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496008831 hypothetical protein; Provisional; Region: PRK04860 595496008832 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 595496008833 DNA-specific endonuclease I; Provisional; Region: PRK15137 595496008834 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 595496008835 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 595496008836 RNA methyltransferase, RsmE family; Region: TIGR00046 595496008837 glutathione synthetase; Provisional; Region: PRK05246 595496008838 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 595496008839 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 595496008840 hypothetical protein; Validated; Region: PRK00228 595496008841 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 595496008842 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 595496008843 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 595496008844 Walker A motif; other site 595496008845 ATP binding site [chemical binding]; other site 595496008846 Walker B motif; other site 595496008847 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 595496008848 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 595496008849 catalytic residue [active] 595496008850 YGGT family; Region: YGGT; pfam02325 595496008851 YGGT family; Region: YGGT; pfam02325 595496008852 hypothetical protein; Validated; Region: PRK05090 595496008853 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 595496008854 active site 595496008855 dimerization interface [polypeptide binding]; other site 595496008856 HemN family oxidoreductase; Provisional; Region: PRK05660 595496008857 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 595496008858 FeS/SAM binding site; other site 595496008859 HemN C-terminal domain; Region: HemN_C; pfam06969 595496008860 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 595496008861 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 595496008862 homodimer interface [polypeptide binding]; other site 595496008863 active site 595496008864 hypothetical protein; Provisional; Region: PRK10626 595496008865 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 595496008866 hypothetical protein; Provisional; Region: PRK11702 595496008867 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 595496008868 adenine DNA glycosylase; Provisional; Region: PRK10880 595496008869 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 595496008870 minor groove reading motif; other site 595496008871 helix-hairpin-helix signature motif; other site 595496008872 substrate binding pocket [chemical binding]; other site 595496008873 active site 595496008874 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 595496008875 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 595496008876 DNA binding and oxoG recognition site [nucleotide binding] 595496008877 oxidative damage protection protein; Provisional; Region: PRK05408 595496008878 murein transglycosylase C; Provisional; Region: mltC; PRK11671 595496008879 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 595496008880 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 595496008881 N-acetyl-D-glucosamine binding site [chemical binding]; other site 595496008882 catalytic residue [active] 595496008883 nucleoside transporter; Region: 2A0110; TIGR00889 595496008884 ornithine decarboxylase; Provisional; Region: PRK13578 595496008885 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 595496008886 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 595496008887 homodimer interface [polypeptide binding]; other site 595496008888 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496008889 catalytic residue [active] 595496008890 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 595496008891 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 595496008892 putative general secretion pathway protein YghD; Provisional; Region: PRK09731 595496008893 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 595496008894 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 595496008895 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 595496008896 Domain of unknown function (DUF4092); Region: DUF4092; pfam13322 595496008897 Peptidase M60-like family; Region: M60-like; pfam13402 595496008898 glycolate transporter; Provisional; Region: PRK09695 595496008899 L-lactate permease; Region: Lactate_perm; cl00701 595496008900 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 595496008901 active site 595496008902 hypothetical protein; Provisional; Region: PRK09732 595496008903 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 595496008904 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 595496008905 Cysteine-rich domain; Region: CCG; pfam02754 595496008906 Cysteine-rich domain; Region: CCG; pfam02754 595496008907 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 595496008908 FAD binding domain; Region: FAD_binding_4; pfam01565 595496008909 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 595496008910 FAD binding domain; Region: FAD_binding_4; pfam01565 595496008911 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 595496008912 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 595496008913 DNA-binding site [nucleotide binding]; DNA binding site 595496008914 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 595496008915 Transposase domain (DUF772); Region: DUF772; pfam05598 595496008916 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 595496008917 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 595496008918 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 595496008919 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 595496008920 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 595496008921 Thymidylate kinase; Region: Thymidylate_kin; pfam02223 595496008922 active site 595496008923 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 595496008924 TMP-binding site; other site 595496008925 ATP-binding site [chemical binding]; other site 595496008926 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 595496008927 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 595496008928 TMP-binding site; other site 595496008929 ATP-binding site [chemical binding]; other site 595496008930 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 595496008931 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 595496008932 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 595496008933 CHAP domain; Region: CHAP; pfam05257 595496008934 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 595496008935 putative S-transferase; Provisional; Region: PRK11752 595496008936 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 595496008937 C-terminal domain interface [polypeptide binding]; other site 595496008938 GSH binding site (G-site) [chemical binding]; other site 595496008939 dimer interface [polypeptide binding]; other site 595496008940 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 595496008941 dimer interface [polypeptide binding]; other site 595496008942 N-terminal domain interface [polypeptide binding]; other site 595496008943 active site 595496008944 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 595496008945 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 595496008946 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 595496008947 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 595496008948 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 595496008949 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 595496008950 putative substrate-binding site; other site 595496008951 nickel binding site [ion binding]; other site 595496008952 hydrogenase 2 large subunit; Provisional; Region: PRK10467 595496008953 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 595496008954 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 595496008955 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 595496008956 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 595496008957 4Fe-4S binding domain; Region: Fer4_6; pfam12837 595496008958 hydrogenase 2 small subunit; Provisional; Region: PRK10468 595496008959 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 595496008960 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 595496008961 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 595496008962 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 595496008963 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 595496008964 active site 595496008965 catalytic tetrad [active] 595496008966 hypothetical protein; Provisional; Region: PRK05208 595496008967 oxidoreductase; Provisional; Region: PRK07985 595496008968 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 595496008969 NAD binding site [chemical binding]; other site 595496008970 metal binding site [ion binding]; metal-binding site 595496008971 active site 595496008972 biopolymer transport protein ExbD; Provisional; Region: PRK11267 595496008973 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 595496008974 biopolymer transport protein ExbB; Provisional; Region: PRK10414 595496008975 cystathionine beta-lyase; Provisional; Region: PRK08114 595496008976 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 595496008977 homodimer interface [polypeptide binding]; other site 595496008978 substrate-cofactor binding pocket; other site 595496008979 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496008980 catalytic residue [active] 595496008981 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 595496008982 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 595496008983 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 595496008984 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 595496008985 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 595496008986 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 595496008987 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 595496008988 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 595496008989 dimer interface [polypeptide binding]; other site 595496008990 active site 595496008991 metal binding site [ion binding]; metal-binding site 595496008992 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 595496008993 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 595496008994 active site 595496008995 catalytic tetrad [active] 595496008996 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 595496008997 putative outer membrane lipoprotein; Provisional; Region: PRK09973 595496008998 hypothetical protein; Provisional; Region: PRK01254 595496008999 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 595496009000 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 595496009001 FtsI repressor; Provisional; Region: PRK10883 595496009002 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 595496009003 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 595496009004 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 595496009005 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 595496009006 putative acyl-acceptor binding pocket; other site 595496009007 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 595496009008 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 595496009009 CAP-like domain; other site 595496009010 active site 595496009011 primary dimer interface [polypeptide binding]; other site 595496009012 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 595496009013 putative ABC transporter periplasmic-binding protein; Provisional; Region: PRK09755 595496009014 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 595496009015 peptide binding site [polypeptide binding]; other site 595496009016 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 595496009017 toxin interface [polypeptide binding]; other site 595496009018 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 595496009019 Zn binding site [ion binding]; other site 595496009020 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 595496009021 non-specific DNA binding site [nucleotide binding]; other site 595496009022 salt bridge; other site 595496009023 sequence-specific DNA binding site [nucleotide binding]; other site 595496009024 Motility quorum-sensing regulator (MqsR); Region: MqsR; cd12869 595496009025 peptide binding site [polypeptide binding]; other site 595496009026 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 595496009027 TIGR00156 family protein; Region: TIGR00156 595496009028 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 595496009029 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 595496009030 active site 595496009031 phosphorylation site [posttranslational modification] 595496009032 intermolecular recognition site; other site 595496009033 dimerization interface [polypeptide binding]; other site 595496009034 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 595496009035 DNA binding site [nucleotide binding] 595496009036 sensor protein QseC; Provisional; Region: PRK10337 595496009037 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 595496009038 dimer interface [polypeptide binding]; other site 595496009039 phosphorylation site [posttranslational modification] 595496009040 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 595496009041 ATP binding site [chemical binding]; other site 595496009042 Mg2+ binding site [ion binding]; other site 595496009043 G-X-G motif; other site 595496009044 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 595496009045 Uncharacterized conserved protein [Function unknown]; Region: COG1359 595496009046 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 595496009047 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 595496009048 ATP binding site [chemical binding]; other site 595496009049 Mg2+ binding site [ion binding]; other site 595496009050 G-X-G motif; other site 595496009051 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 595496009052 anchoring element; other site 595496009053 dimer interface [polypeptide binding]; other site 595496009054 ATP binding site [chemical binding]; other site 595496009055 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 595496009056 active site 595496009057 metal binding site [ion binding]; metal-binding site 595496009058 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 595496009059 esterase YqiA; Provisional; Region: PRK11071 595496009060 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 595496009061 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 595496009062 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 595496009063 active site 595496009064 metal binding site [ion binding]; metal-binding site 595496009065 hexamer interface [polypeptide binding]; other site 595496009066 putative dehydrogenase; Provisional; Region: PRK11039 595496009067 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 595496009068 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 595496009069 dimer interface [polypeptide binding]; other site 595496009070 ADP-ribose binding site [chemical binding]; other site 595496009071 active site 595496009072 nudix motif; other site 595496009073 metal binding site [ion binding]; metal-binding site 595496009074 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 595496009075 hypothetical protein; Provisional; Region: PRK11653 595496009076 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 595496009077 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 595496009078 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 595496009079 putative active site [active] 595496009080 metal binding site [ion binding]; metal-binding site 595496009081 zinc transporter ZupT; Provisional; Region: PRK04201 595496009082 ZIP Zinc transporter; Region: Zip; pfam02535 595496009083 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 595496009084 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 595496009085 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 595496009086 putative fimbrial protein; Provisional; Region: PRK09733 595496009087 IS2 repressor TnpA; Reviewed; Region: PRK09413 595496009088 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 595496009089 IS2 transposase TnpB; Reviewed; Region: PRK09409 595496009090 HTH-like domain; Region: HTH_21; pfam13276 595496009091 Integrase core domain; Region: rve; pfam00665 595496009092 Integrase core domain; Region: rve_3; pfam13683 595496009093 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 595496009094 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 595496009095 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 595496009096 Fimbrial protein; Region: Fimbrial; pfam00419 595496009097 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 595496009098 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 595496009099 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 595496009100 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 595496009101 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 595496009102 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 595496009103 putative ribose interaction site [chemical binding]; other site 595496009104 putative ADP binding site [chemical binding]; other site 595496009105 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 595496009106 active site 595496009107 nucleotide binding site [chemical binding]; other site 595496009108 HIGH motif; other site 595496009109 KMSKS motif; other site 595496009110 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 595496009111 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 595496009112 metal binding triad; other site 595496009113 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 595496009114 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 595496009115 metal binding triad; other site 595496009116 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 595496009117 Uncharacterized conserved protein [Function unknown]; Region: COG3025 595496009118 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 595496009119 putative active site [active] 595496009120 putative metal binding residues [ion binding]; other site 595496009121 signature motif; other site 595496009122 putative triphosphate binding site [ion binding]; other site 595496009123 CHAD domain; Region: CHAD; pfam05235 595496009124 SH3 domain-containing protein; Provisional; Region: PRK10884 595496009125 Bacterial SH3 domain homologues; Region: SH3b; smart00287 595496009126 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 595496009127 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 595496009128 active site 595496009129 NTP binding site [chemical binding]; other site 595496009130 metal binding triad [ion binding]; metal-binding site 595496009131 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 595496009132 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 595496009133 Zn2+ binding site [ion binding]; other site 595496009134 Mg2+ binding site [ion binding]; other site 595496009135 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 595496009136 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 595496009137 homooctamer interface [polypeptide binding]; other site 595496009138 active site 595496009139 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 595496009140 transcriptional activator TtdR; Provisional; Region: PRK09801 595496009141 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496009142 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 595496009143 putative effector binding pocket; other site 595496009144 putative dimerization interface [polypeptide binding]; other site 595496009145 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 595496009146 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 595496009147 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 595496009148 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 595496009149 transmembrane helices; other site 595496009150 UGMP family protein; Validated; Region: PRK09604 595496009151 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 595496009152 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 595496009153 DNA primase; Validated; Region: dnaG; PRK05667 595496009154 CHC2 zinc finger; Region: zf-CHC2; pfam01807 595496009155 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 595496009156 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 595496009157 active site 595496009158 metal binding site [ion binding]; metal-binding site 595496009159 interdomain interaction site; other site 595496009160 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 595496009161 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 595496009162 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 595496009163 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 595496009164 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 595496009165 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 595496009166 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 595496009167 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 595496009168 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 595496009169 DNA binding residues [nucleotide binding] 595496009170 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 595496009171 active site 595496009172 SUMO-1 interface [polypeptide binding]; other site 595496009173 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 595496009174 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 595496009175 FAD binding pocket [chemical binding]; other site 595496009176 FAD binding motif [chemical binding]; other site 595496009177 phosphate binding motif [ion binding]; other site 595496009178 NAD binding pocket [chemical binding]; other site 595496009179 Predicted transcriptional regulators [Transcription]; Region: COG1695 595496009180 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 595496009181 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 595496009182 PAS fold; Region: PAS_3; pfam08447 595496009183 putative active site [active] 595496009184 heme pocket [chemical binding]; other site 595496009185 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 595496009186 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 595496009187 dimer interface [polypeptide binding]; other site 595496009188 putative CheW interface [polypeptide binding]; other site 595496009189 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 595496009190 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 595496009191 inhibitor-cofactor binding pocket; inhibition site 595496009192 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496009193 catalytic residue [active] 595496009194 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 595496009195 dimer interface [polypeptide binding]; other site 595496009196 putative tRNA-binding site [nucleotide binding]; other site 595496009197 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 595496009198 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 595496009199 DNA binding site [nucleotide binding] 595496009200 domain linker motif; other site 595496009201 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 595496009202 putative dimerization interface [polypeptide binding]; other site 595496009203 putative ligand binding site [chemical binding]; other site 595496009204 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 595496009205 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 595496009206 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 595496009207 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 595496009208 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 595496009209 cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202 595496009210 inner membrane transporter YjeM; Provisional; Region: PRK15238 595496009211 alpha-glucosidase; Provisional; Region: PRK10137 595496009212 Protein of unknown function, DUF608; Region: DUF608; pfam04685 595496009213 Trehalase; Region: Trehalase; cl17346 595496009214 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 595496009215 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 595496009216 active site 595496009217 FMN binding site [chemical binding]; other site 595496009218 2,4-decadienoyl-CoA binding site; other site 595496009219 catalytic residue [active] 595496009220 4Fe-4S cluster binding site [ion binding]; other site 595496009221 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 595496009222 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 595496009223 non-specific DNA binding site [nucleotide binding]; other site 595496009224 salt bridge; other site 595496009225 sequence-specific DNA binding site [nucleotide binding]; other site 595496009226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680 595496009227 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 595496009228 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 595496009229 S-adenosylmethionine binding site [chemical binding]; other site 595496009230 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 595496009231 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 595496009232 putative active site [active] 595496009233 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 595496009234 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 595496009235 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 595496009236 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 595496009237 serine/threonine transporter SstT; Provisional; Region: PRK13628 595496009238 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 595496009239 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 595496009240 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 595496009241 galactarate dehydratase; Region: galactar-dH20; TIGR03248 595496009242 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 595496009243 Glucuronate isomerase; Region: UxaC; pfam02614 595496009244 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 595496009245 D-galactonate transporter; Region: 2A0114; TIGR00893 595496009246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496009247 putative substrate translocation pore; other site 595496009248 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 595496009249 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 595496009250 DNA-binding site [nucleotide binding]; DNA binding site 595496009251 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 595496009252 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 595496009253 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 595496009254 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 595496009255 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 595496009256 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 595496009257 Predicted membrane protein [Function unknown]; Region: COG5393 595496009258 YqjK-like protein; Region: YqjK; pfam13997 595496009259 Predicted membrane protein [Function unknown]; Region: COG2259 595496009260 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 595496009261 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 595496009262 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 595496009263 putative dimer interface [polypeptide binding]; other site 595496009264 N-terminal domain interface [polypeptide binding]; other site 595496009265 putative substrate binding pocket (H-site) [chemical binding]; other site 595496009266 Predicted membrane protein [Function unknown]; Region: COG3152 595496009267 Predicted membrane protein [Function unknown]; Region: COG3152 595496009268 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496009269 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 595496009270 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 595496009271 dimerization interface [polypeptide binding]; other site 595496009272 Pirin-related protein [General function prediction only]; Region: COG1741 595496009273 Pirin; Region: Pirin; pfam02678 595496009274 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 595496009275 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 595496009276 serine transporter; Region: stp; TIGR00814 595496009277 L-serine dehydratase TdcG; Provisional; Region: PRK15040 595496009278 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 595496009279 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 595496009280 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 595496009281 homotrimer interaction site [polypeptide binding]; other site 595496009282 putative active site [active] 595496009283 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 595496009284 Pyruvate formate lyase 1; Region: PFL1; cd01678 595496009285 coenzyme A binding site [chemical binding]; other site 595496009286 active site 595496009287 catalytic residues [active] 595496009288 glycine loop; other site 595496009289 propionate/acetate kinase; Provisional; Region: PRK12379 595496009290 Acetokinase family; Region: Acetate_kinase; cl17229 595496009291 threonine/serine transporter TdcC; Provisional; Region: PRK13629 595496009292 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 595496009293 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 595496009294 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 595496009295 tetramer interface [polypeptide binding]; other site 595496009296 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496009297 catalytic residue [active] 595496009298 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 595496009299 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496009300 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 595496009301 putative substrate binding pocket [chemical binding]; other site 595496009302 putative dimerization interface [polypeptide binding]; other site 595496009303 DNA-binding transcriptional activator TdcR; Provisional; Region: PRK11424 595496009304 hypothetical protein; Provisional; Region: PRK09716 595496009305 glycerate kinase I; Provisional; Region: PRK10342 595496009306 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 595496009307 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 595496009308 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 595496009309 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496009310 D-galactonate transporter; Region: 2A0114; TIGR00893 595496009311 putative substrate translocation pore; other site 595496009312 galactarate dehydratase; Region: galactar-dH20; TIGR03248 595496009313 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 595496009314 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 595496009315 putative regulator PrlF; Provisional; Region: PRK09974 595496009316 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 595496009317 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 595496009318 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 595496009319 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 595496009320 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 595496009321 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 595496009322 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 595496009323 active site 595496009324 phosphorylation site [posttranslational modification] 595496009325 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 595496009326 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 595496009327 dimer interface [polypeptide binding]; other site 595496009328 active site 595496009329 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 595496009330 putative active site [active] 595496009331 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cd00453 595496009332 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 595496009333 active site 595496009334 intersubunit interface [polypeptide binding]; other site 595496009335 zinc binding site [ion binding]; other site 595496009336 Na+ binding site [ion binding]; other site 595496009337 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 595496009338 active site 595496009339 phosphorylation site [posttranslational modification] 595496009340 PTS system N-acetylgalactosamine-specific transporter subunit IIC; Provisional; Region: PRK09757 595496009341 PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855 595496009342 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 595496009343 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 595496009344 active site 595496009345 trimer interface [polypeptide binding]; other site 595496009346 allosteric site; other site 595496009347 active site lid [active] 595496009348 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 595496009349 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 595496009350 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 595496009351 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 595496009352 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 595496009353 PapC N-terminal domain; Region: PapC_N; pfam13954 595496009354 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 595496009355 PapC C-terminal domain; Region: PapC_C; pfam13953 595496009356 Fimbrial protein; Region: Fimbrial; pfam00419 595496009357 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 595496009358 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 595496009359 putative SAM binding site [chemical binding]; other site 595496009360 putative homodimer interface [polypeptide binding]; other site 595496009361 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 595496009362 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 595496009363 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 595496009364 putative ligand binding site [chemical binding]; other site 595496009365 TIGR00252 family protein; Region: TIGR00252 595496009366 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 595496009367 dimer interface [polypeptide binding]; other site 595496009368 active site 595496009369 outer membrane lipoprotein; Provisional; Region: PRK11023 595496009370 BON domain; Region: BON; pfam04972 595496009371 BON domain; Region: BON; pfam04972 595496009372 Predicted permease; Region: DUF318; pfam03773 595496009373 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 595496009374 NADH(P)-binding; Region: NAD_binding_10; pfam13460 595496009375 NAD binding site [chemical binding]; other site 595496009376 active site 595496009377 intracellular protease, PfpI family; Region: PfpI; TIGR01382 595496009378 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 595496009379 proposed catalytic triad [active] 595496009380 conserved cys residue [active] 595496009381 hypothetical protein; Provisional; Region: PRK03467 595496009382 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 595496009383 GIY-YIG motif/motif A; other site 595496009384 putative active site [active] 595496009385 putative metal binding site [ion binding]; other site 595496009386 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 595496009387 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 595496009388 Coenzyme A binding pocket [chemical binding]; other site 595496009389 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 595496009390 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 595496009391 Peptidase family U32; Region: Peptidase_U32; pfam01136 595496009392 putative protease; Provisional; Region: PRK15447 595496009393 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 595496009394 hypothetical protein; Provisional; Region: PRK10508 595496009395 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 595496009396 tryptophan permease; Provisional; Region: PRK10483 595496009397 aromatic amino acid transport protein; Region: araaP; TIGR00837 595496009398 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 595496009399 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 595496009400 ATP binding site [chemical binding]; other site 595496009401 Mg++ binding site [ion binding]; other site 595496009402 motif III; other site 595496009403 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 595496009404 nucleotide binding region [chemical binding]; other site 595496009405 ATP-binding site [chemical binding]; other site 595496009406 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 595496009407 putative RNA binding site [nucleotide binding]; other site 595496009408 lipoprotein NlpI; Provisional; Region: PRK11189 595496009409 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 595496009410 binding surface 595496009411 TPR motif; other site 595496009412 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 595496009413 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 595496009414 RNase E interface [polypeptide binding]; other site 595496009415 trimer interface [polypeptide binding]; other site 595496009416 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 595496009417 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 595496009418 RNase E interface [polypeptide binding]; other site 595496009419 trimer interface [polypeptide binding]; other site 595496009420 active site 595496009421 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 595496009422 putative nucleic acid binding region [nucleotide binding]; other site 595496009423 G-X-X-G motif; other site 595496009424 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 595496009425 RNA binding site [nucleotide binding]; other site 595496009426 domain interface; other site 595496009427 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 595496009428 16S/18S rRNA binding site [nucleotide binding]; other site 595496009429 S13e-L30e interaction site [polypeptide binding]; other site 595496009430 25S rRNA binding site [nucleotide binding]; other site 595496009431 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 595496009432 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 595496009433 RNA binding site [nucleotide binding]; other site 595496009434 active site 595496009435 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 595496009436 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 595496009437 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 595496009438 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 595496009439 translation initiation factor IF-2; Region: IF-2; TIGR00487 595496009440 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 595496009441 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 595496009442 G1 box; other site 595496009443 putative GEF interaction site [polypeptide binding]; other site 595496009444 GTP/Mg2+ binding site [chemical binding]; other site 595496009445 Switch I region; other site 595496009446 G2 box; other site 595496009447 G3 box; other site 595496009448 Switch II region; other site 595496009449 G4 box; other site 595496009450 G5 box; other site 595496009451 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 595496009452 Translation-initiation factor 2; Region: IF-2; pfam11987 595496009453 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 595496009454 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 595496009455 NusA N-terminal domain; Region: NusA_N; pfam08529 595496009456 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 595496009457 RNA binding site [nucleotide binding]; other site 595496009458 homodimer interface [polypeptide binding]; other site 595496009459 NusA-like KH domain; Region: KH_5; pfam13184 595496009460 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 595496009461 G-X-X-G motif; other site 595496009462 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 595496009463 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 595496009464 ribosome maturation protein RimP; Reviewed; Region: PRK00092 595496009465 Sm and related proteins; Region: Sm_like; cl00259 595496009466 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 595496009467 putative oligomer interface [polypeptide binding]; other site 595496009468 putative RNA binding site [nucleotide binding]; other site 595496009469 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 595496009470 ANP binding site [chemical binding]; other site 595496009471 Substrate Binding Site II [chemical binding]; other site 595496009472 Substrate Binding Site I [chemical binding]; other site 595496009473 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 595496009474 Sulfatase; Region: Sulfatase; pfam00884 595496009475 Preprotein translocase SecG subunit; Region: SecG; pfam03840 595496009476 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 595496009477 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 595496009478 active site 595496009479 substrate binding site [chemical binding]; other site 595496009480 metal binding site [ion binding]; metal-binding site 595496009481 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 595496009482 dihydropteroate synthase; Region: DHPS; TIGR01496 595496009483 substrate binding pocket [chemical binding]; other site 595496009484 dimer interface [polypeptide binding]; other site 595496009485 inhibitor binding site; inhibition site 595496009486 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 595496009487 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 595496009488 Walker A motif; other site 595496009489 ATP binding site [chemical binding]; other site 595496009490 Walker B motif; other site 595496009491 arginine finger; other site 595496009492 Peptidase family M41; Region: Peptidase_M41; pfam01434 595496009493 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 595496009494 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 595496009495 S-adenosylmethionine binding site [chemical binding]; other site 595496009496 RNA-binding protein YhbY; Provisional; Region: PRK10343 595496009497 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 595496009498 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 595496009499 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 595496009500 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 595496009501 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 595496009502 GTPase CgtA; Reviewed; Region: obgE; PRK12298 595496009503 GTP1/OBG; Region: GTP1_OBG; pfam01018 595496009504 Obg GTPase; Region: Obg; cd01898 595496009505 G1 box; other site 595496009506 GTP/Mg2+ binding site [chemical binding]; other site 595496009507 Switch I region; other site 595496009508 G2 box; other site 595496009509 G3 box; other site 595496009510 Switch II region; other site 595496009511 G4 box; other site 595496009512 G5 box; other site 595496009513 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 595496009514 EamA-like transporter family; Region: EamA; pfam00892 595496009515 EamA-like transporter family; Region: EamA; pfam00892 595496009516 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 595496009517 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 595496009518 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 595496009519 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 595496009520 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 595496009521 substrate binding pocket [chemical binding]; other site 595496009522 chain length determination region; other site 595496009523 substrate-Mg2+ binding site; other site 595496009524 catalytic residues [active] 595496009525 aspartate-rich region 1; other site 595496009526 active site lid residues [active] 595496009527 aspartate-rich region 2; other site 595496009528 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 595496009529 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 595496009530 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 595496009531 hinge; other site 595496009532 active site 595496009533 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 595496009534 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 595496009535 anti sigma factor interaction site; other site 595496009536 regulatory phosphorylation site [posttranslational modification]; other site 595496009537 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 595496009538 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 595496009539 mce related protein; Region: MCE; pfam02470 595496009540 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 595496009541 conserved hypothetical integral membrane protein; Region: TIGR00056 595496009542 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 595496009543 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 595496009544 Walker A/P-loop; other site 595496009545 ATP binding site [chemical binding]; other site 595496009546 Q-loop/lid; other site 595496009547 ABC transporter signature motif; other site 595496009548 Walker B; other site 595496009549 D-loop; other site 595496009550 H-loop/switch region; other site 595496009551 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 595496009552 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 595496009553 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 595496009554 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 595496009555 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 595496009556 putative active site [active] 595496009557 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 595496009558 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 595496009559 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 595496009560 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 595496009561 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 595496009562 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 595496009563 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 595496009564 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 595496009565 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 595496009566 Walker A/P-loop; other site 595496009567 ATP binding site [chemical binding]; other site 595496009568 Q-loop/lid; other site 595496009569 ABC transporter signature motif; other site 595496009570 Walker B; other site 595496009571 D-loop; other site 595496009572 H-loop/switch region; other site 595496009573 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 595496009574 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 595496009575 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 595496009576 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 595496009577 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 595496009578 30S subunit binding site; other site 595496009579 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 595496009580 active site 595496009581 phosphorylation site [posttranslational modification] 595496009582 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 595496009583 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 595496009584 dimerization domain swap beta strand [polypeptide binding]; other site 595496009585 regulatory protein interface [polypeptide binding]; other site 595496009586 active site 595496009587 regulatory phosphorylation site [posttranslational modification]; other site 595496009588 hypothetical protein; Provisional; Region: PRK10345 595496009589 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 595496009590 Transglycosylase; Region: Transgly; cl17702 595496009591 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 595496009592 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 595496009593 conserved cys residue [active] 595496009594 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 595496009595 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 595496009596 putative active site [active] 595496009597 heme pocket [chemical binding]; other site 595496009598 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 595496009599 dimer interface [polypeptide binding]; other site 595496009600 phosphorylation site [posttranslational modification] 595496009601 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 595496009602 ATP binding site [chemical binding]; other site 595496009603 Mg2+ binding site [ion binding]; other site 595496009604 G-X-G motif; other site 595496009605 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 595496009606 active site 595496009607 phosphorylation site [posttranslational modification] 595496009608 intermolecular recognition site; other site 595496009609 dimerization interface [polypeptide binding]; other site 595496009610 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 595496009611 putative binding surface; other site 595496009612 active site 595496009613 radical SAM protein, TIGR01212 family; Region: TIGR01212 595496009614 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 595496009615 FeS/SAM binding site; other site 595496009616 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 595496009617 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 595496009618 active site 595496009619 dimer interface [polypeptide binding]; other site 595496009620 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 595496009621 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 595496009622 active site 595496009623 FMN binding site [chemical binding]; other site 595496009624 substrate binding site [chemical binding]; other site 595496009625 3Fe-4S cluster binding site [ion binding]; other site 595496009626 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 595496009627 domain interface; other site 595496009628 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 595496009629 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 595496009630 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 595496009631 Protein of unknown function (DUF1120); Region: DUF1120; pfam06551 595496009632 putative fimbrial chaperone protein; Provisional; Region: PRK09918 595496009633 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 595496009634 putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304 595496009635 PapC N-terminal domain; Region: PapC_N; pfam13954 595496009636 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 595496009637 PapC C-terminal domain; Region: PapC_C; pfam13953 595496009638 Transposase domain (DUF772); Region: DUF772; pfam05598 595496009639 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 595496009640 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 595496009641 Protein of unknown function (DUF1120); Region: DUF1120; pfam06551 595496009642 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 595496009643 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 595496009644 uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022 595496009645 N-acetylmannosamine kinase; Provisional; Region: PRK05082 595496009646 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 595496009647 nucleotide binding site [chemical binding]; other site 595496009648 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 595496009649 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 595496009650 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 595496009651 putative active site cavity [active] 595496009652 putative sialic acid transporter; Provisional; Region: PRK03893 595496009653 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496009654 putative substrate translocation pore; other site 595496009655 N-acetylneuraminate lyase; Region: nanA; TIGR00683 595496009656 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 595496009657 inhibitor site; inhibition site 595496009658 active site 595496009659 dimer interface [polypeptide binding]; other site 595496009660 catalytic residue [active] 595496009661 transcriptional regulator NanR; Provisional; Region: PRK03837 595496009662 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 595496009663 DNA-binding site [nucleotide binding]; DNA binding site 595496009664 FCD domain; Region: FCD; pfam07729 595496009665 putative cryptic C4-dicarboxylate transporter DcuD; Provisional; Region: PRK09804 595496009666 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 595496009667 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 595496009668 stringent starvation protein A; Provisional; Region: sspA; PRK09481 595496009669 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 595496009670 C-terminal domain interface [polypeptide binding]; other site 595496009671 putative GSH binding site (G-site) [chemical binding]; other site 595496009672 dimer interface [polypeptide binding]; other site 595496009673 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 595496009674 dimer interface [polypeptide binding]; other site 595496009675 N-terminal domain interface [polypeptide binding]; other site 595496009676 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 595496009677 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 595496009678 23S rRNA interface [nucleotide binding]; other site 595496009679 L3 interface [polypeptide binding]; other site 595496009680 Predicted ATPase [General function prediction only]; Region: COG1485 595496009681 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 595496009682 hypothetical protein; Provisional; Region: PRK11677 595496009683 serine endoprotease; Provisional; Region: PRK10139 595496009684 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 595496009685 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 595496009686 protein binding site [polypeptide binding]; other site 595496009687 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 595496009688 serine endoprotease; Provisional; Region: PRK10898 595496009689 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 595496009690 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 595496009691 malate dehydrogenase; Provisional; Region: PRK05086 595496009692 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 595496009693 NAD binding site [chemical binding]; other site 595496009694 dimerization interface [polypeptide binding]; other site 595496009695 Substrate binding site [chemical binding]; other site 595496009696 arginine repressor; Provisional; Region: PRK05066 595496009697 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 595496009698 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 595496009699 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 595496009700 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 595496009701 RNAase interaction site [polypeptide binding]; other site 595496009702 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 595496009703 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 595496009704 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 595496009705 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 595496009706 HlyD family secretion protein; Region: HlyD_3; pfam13437 595496009707 efflux system membrane protein; Provisional; Region: PRK11594 595496009708 transcriptional regulator; Provisional; Region: PRK10632 595496009709 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496009710 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 595496009711 putative effector binding pocket; other site 595496009712 dimerization interface [polypeptide binding]; other site 595496009713 protease TldD; Provisional; Region: tldD; PRK10735 595496009714 hypothetical protein; Provisional; Region: PRK10899 595496009715 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 595496009716 ribonuclease G; Provisional; Region: PRK11712 595496009717 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 595496009718 homodimer interface [polypeptide binding]; other site 595496009719 oligonucleotide binding site [chemical binding]; other site 595496009720 Maf-like protein; Region: Maf; pfam02545 595496009721 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 595496009722 active site 595496009723 dimer interface [polypeptide binding]; other site 595496009724 rod shape-determining protein MreD; Provisional; Region: PRK11060 595496009725 rod shape-determining protein MreC; Region: mreC; TIGR00219 595496009726 rod shape-determining protein MreC; Region: MreC; pfam04085 595496009727 rod shape-determining protein MreB; Provisional; Region: PRK13927 595496009728 MreB and similar proteins; Region: MreB_like; cd10225 595496009729 nucleotide binding site [chemical binding]; other site 595496009730 Mg binding site [ion binding]; other site 595496009731 putative protofilament interaction site [polypeptide binding]; other site 595496009732 RodZ interaction site [polypeptide binding]; other site 595496009733 regulatory protein CsrD; Provisional; Region: PRK11059 595496009734 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 595496009735 metal binding site [ion binding]; metal-binding site 595496009736 active site 595496009737 I-site; other site 595496009738 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 595496009739 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 595496009740 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 595496009741 NADP binding site [chemical binding]; other site 595496009742 dimer interface [polypeptide binding]; other site 595496009743 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 595496009744 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 595496009745 carboxyltransferase (CT) interaction site; other site 595496009746 biotinylation site [posttranslational modification]; other site 595496009747 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 595496009748 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 595496009749 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 595496009750 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 595496009751 hypothetical protein; Provisional; Region: PRK10633 595496009752 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 595496009753 Na binding site [ion binding]; other site 595496009754 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 595496009755 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 595496009756 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 595496009757 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 595496009758 FMN binding site [chemical binding]; other site 595496009759 active site 595496009760 catalytic residues [active] 595496009761 substrate binding site [chemical binding]; other site 595496009762 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 595496009763 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 595496009764 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 595496009765 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 595496009766 DNA methylase; Region: N6_N4_Mtase; pfam01555 595496009767 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 595496009768 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 595496009769 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 595496009770 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 595496009771 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 595496009772 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 595496009773 HlyD family secretion protein; Region: HlyD_3; pfam13437 595496009774 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 595496009775 Protein export membrane protein; Region: SecD_SecF; cl14618 595496009776 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 595496009777 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 595496009778 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496009779 conserved gate region; other site 595496009780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496009781 dimer interface [polypeptide binding]; other site 595496009782 conserved gate region; other site 595496009783 putative PBP binding loops; other site 595496009784 ABC-ATPase subunit interface; other site 595496009785 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 595496009786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496009787 dimer interface [polypeptide binding]; other site 595496009788 conserved gate region; other site 595496009789 putative PBP binding loops; other site 595496009790 ABC-ATPase subunit interface; other site 595496009791 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 595496009792 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 595496009793 Walker A/P-loop; other site 595496009794 ATP binding site [chemical binding]; other site 595496009795 Q-loop/lid; other site 595496009796 ABC transporter signature motif; other site 595496009797 Walker B; other site 595496009798 D-loop; other site 595496009799 H-loop/switch region; other site 595496009800 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 595496009801 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 595496009802 trimer interface [polypeptide binding]; other site 595496009803 putative metal binding site [ion binding]; other site 595496009804 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 595496009805 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 595496009806 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 595496009807 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 595496009808 shikimate binding site; other site 595496009809 NAD(P) binding site [chemical binding]; other site 595496009810 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 595496009811 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 595496009812 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 595496009813 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 595496009814 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 595496009815 hypothetical protein; Validated; Region: PRK03430 595496009816 hypothetical protein; Provisional; Region: PRK10736 595496009817 DNA protecting protein DprA; Region: dprA; TIGR00732 595496009818 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 595496009819 active site 595496009820 catalytic residues [active] 595496009821 metal binding site [ion binding]; metal-binding site 595496009822 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 595496009823 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 595496009824 putative active site [active] 595496009825 substrate binding site [chemical binding]; other site 595496009826 putative cosubstrate binding site; other site 595496009827 catalytic site [active] 595496009828 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 595496009829 substrate binding site [chemical binding]; other site 595496009830 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 595496009831 putative RNA binding site [nucleotide binding]; other site 595496009832 16S rRNA methyltransferase B; Provisional; Region: PRK10901 595496009833 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 595496009834 S-adenosylmethionine binding site [chemical binding]; other site 595496009835 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 595496009836 TrkA-N domain; Region: TrkA_N; pfam02254 595496009837 TrkA-C domain; Region: TrkA_C; pfam02080 595496009838 TrkA-N domain; Region: TrkA_N; pfam02254 595496009839 TrkA-C domain; Region: TrkA_C; pfam02080 595496009840 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 595496009841 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 595496009842 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 595496009843 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 595496009844 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 595496009845 DNA binding residues [nucleotide binding] 595496009846 dimer interface [polypeptide binding]; other site 595496009847 metal binding site [ion binding]; metal-binding site 595496009848 hypothetical protein; Provisional; Region: PRK10203 595496009849 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 595496009850 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 595496009851 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 595496009852 alphaNTD homodimer interface [polypeptide binding]; other site 595496009853 alphaNTD - beta interaction site [polypeptide binding]; other site 595496009854 alphaNTD - beta' interaction site [polypeptide binding]; other site 595496009855 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 595496009856 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 595496009857 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 595496009858 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 595496009859 RNA binding surface [nucleotide binding]; other site 595496009860 30S ribosomal protein S11; Validated; Region: PRK05309 595496009861 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 595496009862 30S ribosomal protein S13; Region: bact_S13; TIGR03631 595496009863 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 595496009864 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 595496009865 SecY translocase; Region: SecY; pfam00344 595496009866 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 595496009867 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 595496009868 23S rRNA binding site [nucleotide binding]; other site 595496009869 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 595496009870 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 595496009871 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 595496009872 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 595496009873 23S rRNA interface [nucleotide binding]; other site 595496009874 5S rRNA interface [nucleotide binding]; other site 595496009875 L27 interface [polypeptide binding]; other site 595496009876 L5 interface [polypeptide binding]; other site 595496009877 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 595496009878 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 595496009879 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 595496009880 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 595496009881 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 595496009882 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 595496009883 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 595496009884 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 595496009885 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 595496009886 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 595496009887 RNA binding site [nucleotide binding]; other site 595496009888 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 595496009889 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 595496009890 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 595496009891 23S rRNA interface [nucleotide binding]; other site 595496009892 putative translocon interaction site; other site 595496009893 signal recognition particle (SRP54) interaction site; other site 595496009894 L23 interface [polypeptide binding]; other site 595496009895 trigger factor interaction site; other site 595496009896 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 595496009897 23S rRNA interface [nucleotide binding]; other site 595496009898 5S rRNA interface [nucleotide binding]; other site 595496009899 putative antibiotic binding site [chemical binding]; other site 595496009900 L25 interface [polypeptide binding]; other site 595496009901 L27 interface [polypeptide binding]; other site 595496009902 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 595496009903 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 595496009904 G-X-X-G motif; other site 595496009905 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 595496009906 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 595496009907 protein-rRNA interface [nucleotide binding]; other site 595496009908 putative translocon binding site; other site 595496009909 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 595496009910 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 595496009911 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 595496009912 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 595496009913 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 595496009914 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 595496009915 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 595496009916 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 595496009917 protein secretion protein GspB; Provisional; Region: PRK09697 595496009918 AAA domain; Region: AAA_22; pfam13401 595496009919 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 595496009920 Type II secretory pathway, component PulC [Intracellular trafficking and secretion]; Region: PulC; COG3031 595496009921 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 595496009922 type II secretion system protein D; Region: type_II_gspD; TIGR02517 595496009923 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 595496009924 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 595496009925 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 595496009926 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 595496009927 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 595496009928 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 595496009929 Walker A motif; other site 595496009930 ATP binding site [chemical binding]; other site 595496009931 Walker B motif; other site 595496009932 type II secretion system protein F; Region: GspF; TIGR02120 595496009933 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 595496009934 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 595496009935 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 595496009936 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 595496009937 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 595496009938 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 595496009939 type II secretion system protein I; Region: gspI; TIGR01707 595496009940 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 595496009941 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 595496009942 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 595496009943 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 595496009944 Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156 595496009945 Type II secretory pathway, component PulL [Intracellular trafficking and secretion]; Region: PulL; COG3297 595496009946 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 595496009947 GspL periplasmic domain; Region: GspL_C; pfam12693 595496009948 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 595496009949 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 595496009950 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 595496009951 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 595496009952 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 595496009953 heme binding site [chemical binding]; other site 595496009954 ferroxidase pore; other site 595496009955 ferroxidase diiron center [ion binding]; other site 595496009956 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 595496009957 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 595496009958 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 595496009959 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 595496009960 aromatic chitin/cellulose binding site residues [chemical binding]; other site 595496009961 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 595496009962 active site 595496009963 elongation factor Tu; Reviewed; Region: PRK00049 595496009964 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 595496009965 G1 box; other site 595496009966 GEF interaction site [polypeptide binding]; other site 595496009967 GTP/Mg2+ binding site [chemical binding]; other site 595496009968 Switch I region; other site 595496009969 G2 box; other site 595496009970 G3 box; other site 595496009971 Switch II region; other site 595496009972 G4 box; other site 595496009973 G5 box; other site 595496009974 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 595496009975 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 595496009976 Antibiotic Binding Site [chemical binding]; other site 595496009977 elongation factor G; Reviewed; Region: PRK00007 595496009978 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 595496009979 G1 box; other site 595496009980 putative GEF interaction site [polypeptide binding]; other site 595496009981 GTP/Mg2+ binding site [chemical binding]; other site 595496009982 Switch I region; other site 595496009983 G2 box; other site 595496009984 G3 box; other site 595496009985 Switch II region; other site 595496009986 G4 box; other site 595496009987 G5 box; other site 595496009988 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 595496009989 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 595496009990 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 595496009991 30S ribosomal protein S7; Validated; Region: PRK05302 595496009992 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 595496009993 S17 interaction site [polypeptide binding]; other site 595496009994 S8 interaction site; other site 595496009995 16S rRNA interaction site [nucleotide binding]; other site 595496009996 streptomycin interaction site [chemical binding]; other site 595496009997 23S rRNA interaction site [nucleotide binding]; other site 595496009998 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 595496009999 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 595496010000 sulfur relay protein TusC; Validated; Region: PRK00211 595496010001 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 595496010002 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 595496010003 YheO-like PAS domain; Region: PAS_6; pfam08348 595496010004 HTH domain; Region: HTH_22; pfam13309 595496010005 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 595496010006 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 595496010007 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 595496010008 phi X174 lysis protein; Provisional; Region: PRK02793 595496010009 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 595496010010 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 595496010011 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 595496010012 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 595496010013 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 595496010014 TrkA-N domain; Region: TrkA_N; pfam02254 595496010015 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 595496010016 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 595496010017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 595496010018 Walker A/P-loop; other site 595496010019 ATP binding site [chemical binding]; other site 595496010020 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 595496010021 ABC transporter signature motif; other site 595496010022 Walker B; other site 595496010023 D-loop; other site 595496010024 ABC transporter; Region: ABC_tran_2; pfam12848 595496010025 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 595496010026 putative hydrolase; Provisional; Region: PRK10985 595496010027 hypothetical protein; Provisional; Region: PRK04966 595496010028 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 595496010029 active site 595496010030 hypothetical protein; Provisional; Region: PRK10738 595496010031 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 595496010032 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 595496010033 ligand binding site [chemical binding]; other site 595496010034 flexible hinge region; other site 595496010035 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 595496010036 putative switch regulator; other site 595496010037 non-specific DNA interactions [nucleotide binding]; other site 595496010038 DNA binding site [nucleotide binding] 595496010039 sequence specific DNA binding site [nucleotide binding]; other site 595496010040 putative cAMP binding site [chemical binding]; other site 595496010041 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 595496010042 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 595496010043 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 595496010044 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 595496010045 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 595496010046 inhibitor-cofactor binding pocket; inhibition site 595496010047 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496010048 catalytic residue [active] 595496010049 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 595496010050 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 595496010051 glutamine binding [chemical binding]; other site 595496010052 catalytic triad [active] 595496010053 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 595496010054 cell filamentation protein Fic; Provisional; Region: PRK10347 595496010055 hypothetical protein; Provisional; Region: PRK10204 595496010056 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 595496010057 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 595496010058 substrate binding site [chemical binding]; other site 595496010059 putative transporter; Provisional; Region: PRK03699 595496010060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496010061 putative substrate translocation pore; other site 595496010062 nitrite reductase subunit NirD; Provisional; Region: PRK14989 595496010063 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 595496010064 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 595496010065 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 595496010066 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 595496010067 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 595496010068 nitrite transporter NirC; Provisional; Region: PRK11562 595496010069 siroheme synthase; Provisional; Region: cysG; PRK10637 595496010070 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 595496010071 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 595496010072 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 595496010073 active site 595496010074 SAM binding site [chemical binding]; other site 595496010075 homodimer interface [polypeptide binding]; other site 595496010076 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 595496010077 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 595496010078 hypothetical protein; Provisional; Region: PHA02764 595496010079 fructoselysine-6-P-deglycase; Provisional; Region: frlB; PRK11382 595496010080 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 595496010081 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 595496010082 dimer interface [polypeptide binding]; other site 595496010083 active site 595496010084 fructoselysine 3-epimerase; Provisional; Region: PRK09856 595496010085 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 595496010086 AP (apurinic/apyrimidinic) site pocket; other site 595496010087 DNA interaction; other site 595496010088 Metal-binding active site; metal-binding site 595496010089 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 595496010090 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 595496010091 substrate binding site [chemical binding]; other site 595496010092 ATP binding site [chemical binding]; other site 595496010093 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 595496010094 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 595496010095 DNA-binding site [nucleotide binding]; DNA binding site 595496010096 UTRA domain; Region: UTRA; pfam07702 595496010097 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 595496010098 DNA topoisomerase III, bacteria and conjugative plasmid; Region: topB; TIGR01056 595496010099 Protein of unknown function; Region: YhfT; pfam10797 595496010100 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 595496010101 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 595496010102 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 595496010103 active site 595496010104 substrate binding pocket [chemical binding]; other site 595496010105 homodimer interaction site [polypeptide binding]; other site 595496010106 putative mutase; Provisional; Region: PRK12383 595496010107 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; COG1015 595496010108 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 595496010109 dimer interface [polypeptide binding]; other site 595496010110 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 595496010111 active site 595496010112 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 595496010113 substrate binding site [chemical binding]; other site 595496010114 catalytic residue [active] 595496010115 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 595496010116 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 595496010117 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 595496010118 active site 595496010119 HIGH motif; other site 595496010120 dimer interface [polypeptide binding]; other site 595496010121 KMSKS motif; other site 595496010122 phosphoglycolate phosphatase; Provisional; Region: PRK13222 595496010123 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 595496010124 motif II; other site 595496010125 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 595496010126 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 595496010127 substrate binding site [chemical binding]; other site 595496010128 hexamer interface [polypeptide binding]; other site 595496010129 metal binding site [ion binding]; metal-binding site 595496010130 DNA adenine methylase; Provisional; Region: PRK10904 595496010131 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 595496010132 cell division protein DamX; Validated; Region: PRK10905 595496010133 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 595496010134 active site 595496010135 dimer interface [polypeptide binding]; other site 595496010136 metal binding site [ion binding]; metal-binding site 595496010137 shikimate kinase; Reviewed; Region: aroK; PRK00131 595496010138 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 595496010139 ADP binding site [chemical binding]; other site 595496010140 magnesium binding site [ion binding]; other site 595496010141 putative shikimate binding site; other site 595496010142 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 595496010143 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 595496010144 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 595496010145 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 595496010146 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 595496010147 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 595496010148 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 595496010149 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 595496010150 Transglycosylase; Region: Transgly; pfam00912 595496010151 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 595496010152 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 595496010153 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 595496010154 ADP-ribose binding site [chemical binding]; other site 595496010155 dimer interface [polypeptide binding]; other site 595496010156 active site 595496010157 nudix motif; other site 595496010158 metal binding site [ion binding]; metal-binding site 595496010159 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 595496010160 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 595496010161 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 595496010162 motif II; other site 595496010163 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 595496010164 RNA binding surface [nucleotide binding]; other site 595496010165 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 595496010166 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 595496010167 dimerization interface [polypeptide binding]; other site 595496010168 domain crossover interface; other site 595496010169 redox-dependent activation switch; other site 595496010170 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 595496010171 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 595496010172 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 595496010173 active site 595496010174 substrate-binding site [chemical binding]; other site 595496010175 metal-binding site [ion binding] 595496010176 ATP binding site [chemical binding]; other site 595496010177 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 595496010178 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 595496010179 dimerization interface [polypeptide binding]; other site 595496010180 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 595496010181 dimer interface [polypeptide binding]; other site 595496010182 phosphorylation site [posttranslational modification] 595496010183 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 595496010184 ATP binding site [chemical binding]; other site 595496010185 G-X-G motif; other site 595496010186 osmolarity response regulator; Provisional; Region: ompR; PRK09468 595496010187 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 595496010188 active site 595496010189 phosphorylation site [posttranslational modification] 595496010190 intermolecular recognition site; other site 595496010191 dimerization interface [polypeptide binding]; other site 595496010192 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 595496010193 DNA binding site [nucleotide binding] 595496010194 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 595496010195 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 595496010196 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 595496010197 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 595496010198 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 595496010199 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 595496010200 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 595496010201 RNA binding site [nucleotide binding]; other site 595496010202 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 595496010203 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 595496010204 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 595496010205 G1 box; other site 595496010206 GTP/Mg2+ binding site [chemical binding]; other site 595496010207 Switch I region; other site 595496010208 G2 box; other site 595496010209 G3 box; other site 595496010210 Switch II region; other site 595496010211 G4 box; other site 595496010212 G5 box; other site 595496010213 Nucleoside recognition; Region: Gate; pfam07670 595496010214 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 595496010215 Nucleoside recognition; Region: Gate; pfam07670 595496010216 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 595496010217 putative transposase; Provisional; Region: PRK09857 595496010218 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 595496010219 carboxylesterase BioH; Provisional; Region: PRK10349 595496010220 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 595496010221 DNA utilization protein GntX; Provisional; Region: PRK11595 595496010222 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 595496010223 active site 595496010224 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 595496010225 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 595496010226 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 595496010227 IS2 repressor TnpA; Reviewed; Region: PRK09413 595496010228 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 595496010229 HTH-like domain; Region: HTH_21; pfam13276 595496010230 Integrase core domain; Region: rve; pfam00665 595496010231 Integrase core domain; Region: rve_3; pfam13683 595496010232 high-affinity gluconate transporter; Provisional; Region: PRK14984 595496010233 gluconate transporter; Region: gntP; TIGR00791 595496010234 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 595496010235 4-alpha-glucanotransferase; Region: malQ; TIGR00217 595496010236 maltodextrin phosphorylase; Provisional; Region: PRK14985 595496010237 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 595496010238 homodimer interface [polypeptide binding]; other site 595496010239 active site pocket [active] 595496010240 transcriptional regulator MalT; Provisional; Region: PRK04841 595496010241 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 595496010242 DNA binding residues [nucleotide binding] 595496010243 dimerization interface [polypeptide binding]; other site 595496010244 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 595496010245 RNA 3' phosphate cyclase domain - RNA phosphate cyclases are enzymes that catalyze the ATP-dependent conversion of 3'-phosphate at the end of RNA into 2', 3'-cyclic phosphodiester bond. The enzymes are conserved in eucaryotes; Region: RNA_Cyclase; cd00295 595496010246 putative active site [active] 595496010247 adenylation catalytic residue [active] 595496010248 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 595496010249 hypothetical protein; Reviewed; Region: PRK09588 595496010250 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 595496010251 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 595496010252 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 595496010253 Walker A motif; other site 595496010254 ATP binding site [chemical binding]; other site 595496010255 Walker B motif; other site 595496010256 arginine finger; other site 595496010257 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 595496010258 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 595496010259 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 595496010260 intramembrane serine protease GlpG; Provisional; Region: PRK10907 595496010261 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 595496010262 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 595496010263 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 595496010264 active site residue [active] 595496010265 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 595496010266 glycogen phosphorylase; Provisional; Region: PRK14986 595496010267 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 595496010268 homodimer interface [polypeptide binding]; other site 595496010269 active site pocket [active] 595496010270 glycogen synthase; Provisional; Region: glgA; PRK00654 595496010271 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 595496010272 ADP-binding pocket [chemical binding]; other site 595496010273 homodimer interface [polypeptide binding]; other site 595496010274 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 595496010275 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 595496010276 ligand binding site; other site 595496010277 oligomer interface; other site 595496010278 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 595496010279 sulfate 1 binding site; other site 595496010280 glycogen debranching enzyme; Provisional; Region: PRK03705 595496010281 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 595496010282 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 595496010283 active site 595496010284 catalytic site [active] 595496010285 glycogen branching enzyme; Provisional; Region: PRK05402 595496010286 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 595496010287 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 595496010288 active site 595496010289 catalytic site [active] 595496010290 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 595496010291 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 595496010292 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 595496010293 putative antibiotic transporter; Provisional; Region: PRK10739 595496010294 low affinity gluconate transporter; Provisional; Region: PRK10472 595496010295 gluconate transporter; Region: gntP; TIGR00791 595496010296 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 595496010297 ATP-binding site [chemical binding]; other site 595496010298 Gluconate-6-phosphate binding site [chemical binding]; other site 595496010299 Shikimate kinase; Region: SKI; pfam01202 595496010300 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 595496010301 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 595496010302 DNA binding site [nucleotide binding] 595496010303 domain linker motif; other site 595496010304 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 595496010305 putative ligand binding site [chemical binding]; other site 595496010306 putative dimerization interface [polypeptide binding]; other site 595496010307 Pirin-related protein [General function prediction only]; Region: COG1741 595496010308 Pirin; Region: Pirin; pfam02678 595496010309 putative oxidoreductase; Provisional; Region: PRK10206 595496010310 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 595496010311 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 595496010312 putative acetyltransferase YhhY; Provisional; Region: PRK10140 595496010313 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 595496010314 Coenzyme A binding pocket [chemical binding]; other site 595496010315 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 595496010316 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 595496010317 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 595496010318 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 595496010319 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 595496010320 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 595496010321 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 595496010322 hypothetical protein; Provisional; Region: PRK10350 595496010323 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 595496010324 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 595496010325 putative active site [active] 595496010326 catalytic site [active] 595496010327 putative metal binding site [ion binding]; other site 595496010328 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 595496010329 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 595496010330 Walker A/P-loop; other site 595496010331 ATP binding site [chemical binding]; other site 595496010332 Q-loop/lid; other site 595496010333 ABC transporter signature motif; other site 595496010334 Walker B; other site 595496010335 D-loop; other site 595496010336 H-loop/switch region; other site 595496010337 TOBE domain; Region: TOBE_2; pfam08402 595496010338 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 595496010339 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496010340 dimer interface [polypeptide binding]; other site 595496010341 conserved gate region; other site 595496010342 putative PBP binding loops; other site 595496010343 ABC-ATPase subunit interface; other site 595496010344 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 595496010345 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496010346 dimer interface [polypeptide binding]; other site 595496010347 conserved gate region; other site 595496010348 putative PBP binding loops; other site 595496010349 ABC-ATPase subunit interface; other site 595496010350 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 595496010351 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 595496010352 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 595496010353 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 595496010354 Walker A/P-loop; other site 595496010355 ATP binding site [chemical binding]; other site 595496010356 Q-loop/lid; other site 595496010357 ABC transporter signature motif; other site 595496010358 Walker B; other site 595496010359 D-loop; other site 595496010360 H-loop/switch region; other site 595496010361 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 595496010362 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 595496010363 Walker A/P-loop; other site 595496010364 ATP binding site [chemical binding]; other site 595496010365 Q-loop/lid; other site 595496010366 ABC transporter signature motif; other site 595496010367 Walker B; other site 595496010368 D-loop; other site 595496010369 H-loop/switch region; other site 595496010370 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 595496010371 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 595496010372 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 595496010373 TM-ABC transporter signature motif; other site 595496010374 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 595496010375 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 595496010376 TM-ABC transporter signature motif; other site 595496010377 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 595496010378 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 595496010379 dimerization interface [polypeptide binding]; other site 595496010380 ligand binding site [chemical binding]; other site 595496010381 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 595496010382 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 595496010383 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 595496010384 dimerization interface [polypeptide binding]; other site 595496010385 ligand binding site [chemical binding]; other site 595496010386 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 595496010387 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 595496010388 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 595496010389 DNA binding residues [nucleotide binding] 595496010390 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 595496010391 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 595496010392 cell division protein FtsE; Provisional; Region: PRK10908 595496010393 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 595496010394 Walker A/P-loop; other site 595496010395 ATP binding site [chemical binding]; other site 595496010396 Q-loop/lid; other site 595496010397 ABC transporter signature motif; other site 595496010398 Walker B; other site 595496010399 D-loop; other site 595496010400 H-loop/switch region; other site 595496010401 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 595496010402 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 595496010403 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 595496010404 P loop; other site 595496010405 GTP binding site [chemical binding]; other site 595496010406 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 595496010407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 595496010408 S-adenosylmethionine binding site [chemical binding]; other site 595496010409 hypothetical protein; Provisional; Region: PRK10910 595496010410 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 595496010411 Predicted membrane protein [Function unknown]; Region: COG3714 595496010412 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 595496010413 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 595496010414 metal-binding site [ion binding] 595496010415 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 595496010416 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 595496010417 CPxP motif; other site 595496010418 hypothetical protein; Provisional; Region: PRK11212 595496010419 hypothetical protein; Provisional; Region: PRK11615 595496010420 major facilitator superfamily transporter; Provisional; Region: PRK05122 595496010421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496010422 putative substrate translocation pore; other site 595496010423 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 595496010424 Domain of unknown function DUF20; Region: UPF0118; pfam01594 595496010425 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 595496010426 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 595496010427 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 595496010428 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 595496010429 substrate binding site [chemical binding]; other site 595496010430 nickel transporter permease NikB; Provisional; Region: PRK10352 595496010431 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496010432 dimer interface [polypeptide binding]; other site 595496010433 conserved gate region; other site 595496010434 putative PBP binding loops; other site 595496010435 ABC-ATPase subunit interface; other site 595496010436 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 595496010437 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496010438 dimer interface [polypeptide binding]; other site 595496010439 conserved gate region; other site 595496010440 putative PBP binding loops; other site 595496010441 ABC-ATPase subunit interface; other site 595496010442 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 595496010443 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 595496010444 Walker A/P-loop; other site 595496010445 ATP binding site [chemical binding]; other site 595496010446 Q-loop/lid; other site 595496010447 ABC transporter signature motif; other site 595496010448 Walker B; other site 595496010449 D-loop; other site 595496010450 H-loop/switch region; other site 595496010451 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 595496010452 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 595496010453 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 595496010454 Walker A/P-loop; other site 595496010455 ATP binding site [chemical binding]; other site 595496010456 Q-loop/lid; other site 595496010457 ABC transporter signature motif; other site 595496010458 Walker B; other site 595496010459 D-loop; other site 595496010460 H-loop/switch region; other site 595496010461 nickel responsive regulator; Provisional; Region: PRK02967 595496010462 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 595496010463 PAAR motif; Region: PAAR_motif; cl15808 595496010464 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 595496010465 RHS Repeat; Region: RHS_repeat; pfam05593 595496010466 RHS Repeat; Region: RHS_repeat; pfam05593 595496010467 RHS Repeat; Region: RHS_repeat; pfam05593 595496010468 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 595496010469 RHS Repeat; Region: RHS_repeat; pfam05593 595496010470 RHS Repeat; Region: RHS_repeat; pfam05593 595496010471 RHS protein; Region: RHS; pfam03527 595496010472 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 595496010473 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 595496010474 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 595496010475 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 595496010476 Transposase [DNA replication, recombination, and repair]; Region: COG5433 595496010477 Transposase [DNA replication, recombination, and repair]; Region: COG5433 595496010478 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 595496010479 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 595496010480 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 595496010481 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 595496010482 Walker A/P-loop; other site 595496010483 ATP binding site [chemical binding]; other site 595496010484 Q-loop/lid; other site 595496010485 ABC transporter signature motif; other site 595496010486 Walker B; other site 595496010487 D-loop; other site 595496010488 H-loop/switch region; other site 595496010489 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 595496010490 Walker A/P-loop; other site 595496010491 ATP binding site [chemical binding]; other site 595496010492 Q-loop/lid; other site 595496010493 ABC transporter signature motif; other site 595496010494 Walker B; other site 595496010495 D-loop; other site 595496010496 H-loop/switch region; other site 595496010497 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 595496010498 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 595496010499 HlyD family secretion protein; Region: HlyD; pfam00529 595496010500 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 595496010501 HlyD family secretion protein; Region: HlyD_3; pfam13437 595496010502 Domain of unknown function (DUF4049); Region: DUF4049; pfam13258 595496010503 Protein of unknown function (DUF2776); Region: DUF2776; pfam10951 595496010504 Predicted flavoproteins [General function prediction only]; Region: COG2081 595496010505 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 595496010506 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 595496010507 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 595496010508 universal stress protein UspB; Provisional; Region: PRK04960 595496010509 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 595496010510 Ligand Binding Site [chemical binding]; other site 595496010511 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 595496010512 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496010513 POT family; Region: PTR2; pfam00854 595496010514 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 595496010515 S-adenosylmethionine binding site [chemical binding]; other site 595496010516 oligopeptidase A; Provisional; Region: PRK10911 595496010517 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 595496010518 active site 595496010519 Zn binding site [ion binding]; other site 595496010520 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 595496010521 glutathione reductase; Validated; Region: PRK06116 595496010522 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 595496010523 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 595496010524 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 595496010525 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 595496010526 dimerization interface [polypeptide binding]; other site 595496010527 putative DNA binding site [nucleotide binding]; other site 595496010528 putative Zn2+ binding site [ion binding]; other site 595496010529 arsenical pump membrane protein; Provisional; Region: PRK15445 595496010530 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 595496010531 transmembrane helices; other site 595496010532 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 595496010533 ArsC family; Region: ArsC; pfam03960 595496010534 catalytic residues [active] 595496010535 Transposase domain (DUF772); Region: DUF772; pfam05598 595496010536 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 595496010537 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 595496010538 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 595496010539 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 595496010540 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 595496010541 DNA binding residues [nucleotide binding] 595496010542 dimerization interface [polypeptide binding]; other site 595496010543 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 595496010544 MgtC family; Region: MgtC; pfam02308 595496010545 acid-resistance protein; Provisional; Region: hdeB; PRK11566 595496010546 acid-resistance protein; Provisional; Region: PRK10208 595496010547 acid-resistance membrane protein; Provisional; Region: PRK10209 595496010548 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 595496010549 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 595496010550 pyruvate kinase; Provisional; Region: PRK05826 595496010551 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 595496010552 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 595496010553 HlyD family secretion protein; Region: HlyD_3; pfam13437 595496010554 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 595496010555 Protein export membrane protein; Region: SecD_SecF; cl14618 595496010556 transcriptional regulator YdeO; Provisional; Region: PRK09940 595496010557 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 595496010558 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 595496010559 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 595496010560 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 595496010561 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496010562 catalytic residue [active] 595496010563 Haem-binding domain; Region: Haem_bd; pfam14376 595496010564 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 595496010565 trehalase; Provisional; Region: treF; PRK13270 595496010566 Trehalase; Region: Trehalase; pfam01204 595496010567 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 595496010568 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 595496010569 DNA binding residues [nucleotide binding] 595496010570 dimerization interface [polypeptide binding]; other site 595496010571 Transcriptional regulator [Transcription]; Region: LysR; COG0583 595496010572 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496010573 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 595496010574 putative effector binding pocket; other site 595496010575 putative dimerization interface [polypeptide binding]; other site 595496010576 inner membrane protein YhjD; Region: TIGR00766 595496010577 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496010578 metabolite-proton symporter; Region: 2A0106; TIGR00883 595496010579 putative substrate translocation pore; other site 595496010580 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 595496010581 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 595496010582 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 595496010583 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 595496010584 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 595496010585 substrate binding site [chemical binding]; other site 595496010586 ATP binding site [chemical binding]; other site 595496010587 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 595496010588 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 595496010589 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 595496010590 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 595496010591 putative diguanylate cyclase; Provisional; Region: PRK13561 595496010592 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 595496010593 metal binding site [ion binding]; metal-binding site 595496010594 active site 595496010595 I-site; other site 595496010596 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 595496010597 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 595496010598 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 595496010599 binding surface 595496010600 TPR motif; other site 595496010601 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 595496010602 binding surface 595496010603 TPR motif; other site 595496010604 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 595496010605 endo-1,4-D-glucanase; Provisional; Region: PRK11097 595496010606 cellulose synthase regulator protein; Provisional; Region: PRK11114 595496010607 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 595496010608 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 595496010609 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 595496010610 DXD motif; other site 595496010611 PilZ domain; Region: PilZ; pfam07238 595496010612 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 595496010613 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 595496010614 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 595496010615 celllulose biosynthesis operon protein BcsF/YhjT; Region: cellullose_BcsF; TIGR03493 595496010616 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 595496010617 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 595496010618 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 595496010619 serine transporter; Region: stp; TIGR00814 595496010620 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 595496010621 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 595496010622 Walker A/P-loop; other site 595496010623 ATP binding site [chemical binding]; other site 595496010624 Q-loop/lid; other site 595496010625 ABC transporter signature motif; other site 595496010626 Walker B; other site 595496010627 D-loop; other site 595496010628 H-loop/switch region; other site 595496010629 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 595496010630 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 595496010631 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 595496010632 Walker A/P-loop; other site 595496010633 ATP binding site [chemical binding]; other site 595496010634 Q-loop/lid; other site 595496010635 ABC transporter signature motif; other site 595496010636 Walker B; other site 595496010637 D-loop; other site 595496010638 H-loop/switch region; other site 595496010639 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 595496010640 dipeptide transporter; Provisional; Region: PRK10913 595496010641 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 595496010642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496010643 dimer interface [polypeptide binding]; other site 595496010644 conserved gate region; other site 595496010645 putative PBP binding loops; other site 595496010646 ABC-ATPase subunit interface; other site 595496010647 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 595496010648 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496010649 dimer interface [polypeptide binding]; other site 595496010650 conserved gate region; other site 595496010651 putative PBP binding loops; other site 595496010652 ABC-ATPase subunit interface; other site 595496010653 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 595496010654 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 595496010655 peptide binding site [polypeptide binding]; other site 595496010656 phosphoethanolamine transferase; Provisional; Region: PRK11560 595496010657 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 595496010658 Sulfatase; Region: Sulfatase; pfam00884 595496010659 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 595496010660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496010661 putative substrate translocation pore; other site 595496010662 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 595496010663 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 595496010664 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 595496010665 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 595496010666 Coenzyme A binding pocket [chemical binding]; other site 595496010667 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 595496010668 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 595496010669 molybdopterin cofactor binding site [chemical binding]; other site 595496010670 substrate binding site [chemical binding]; other site 595496010671 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 595496010672 molybdopterin cofactor binding site; other site 595496010673 putative outer membrane lipoprotein; Provisional; Region: PRK10510 595496010674 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 595496010675 ligand binding site [chemical binding]; other site 595496010676 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 595496010677 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 595496010678 dimerization interface [polypeptide binding]; other site 595496010679 ligand binding site [chemical binding]; other site 595496010680 NADP binding site [chemical binding]; other site 595496010681 catalytic site [active] 595496010682 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 595496010683 Predicted transcriptional regulator [Transcription]; Region: COG2944 595496010684 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 595496010685 non-specific DNA binding site [nucleotide binding]; other site 595496010686 salt bridge; other site 595496010687 sequence-specific DNA binding site [nucleotide binding]; other site 595496010688 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 595496010689 DNA-binding site [nucleotide binding]; DNA binding site 595496010690 RNA-binding motif; other site 595496010691 small toxic polypeptide; Provisional; Region: PRK09759 595496010692 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 595496010693 Helix-turn-helix domain; Region: HTH_28; pfam13518 595496010694 Helix-turn-helix domain; Region: HTH_28; pfam13518 595496010695 putative transposase OrfB; Reviewed; Region: PHA02517 595496010696 HTH-like domain; Region: HTH_21; pfam13276 595496010697 Integrase core domain; Region: rve; pfam00665 595496010698 Integrase core domain; Region: rve_2; pfam13333 595496010699 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 595496010700 DALR anticodon binding domain; Region: DALR_1; pfam05746 595496010701 anticodon binding site; other site 595496010702 tRNA binding surface [nucleotide binding]; other site 595496010703 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 595496010704 dimer interface [polypeptide binding]; other site 595496010705 motif 1; other site 595496010706 active site 595496010707 motif 2; other site 595496010708 motif 3; other site 595496010709 YsaB-like lipoprotein; Region: YsaB; pfam13983 595496010710 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 595496010711 Acyltransferase family; Region: Acyl_transf_3; pfam01757 595496010712 hypothetical protein; Provisional; Region: PRK11383 595496010713 yiaA/B two helix domain; Region: YiaAB; pfam05360 595496010714 yiaA/B two helix domain; Region: YiaAB; pfam05360 595496010715 hypothetical protein; Provisional; Region: PRK11403 595496010716 yiaA/B two helix domain; Region: YiaAB; pfam05360 595496010717 xylulokinase; Provisional; Region: PRK15027 595496010718 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 595496010719 N- and C-terminal domain interface [polypeptide binding]; other site 595496010720 active site 595496010721 MgATP binding site [chemical binding]; other site 595496010722 catalytic site [active] 595496010723 metal binding site [ion binding]; metal-binding site 595496010724 xylulose binding site [chemical binding]; other site 595496010725 homodimer interface [polypeptide binding]; other site 595496010726 xylose isomerase; Provisional; Region: PRK05474 595496010727 xylose isomerase; Region: xylose_isom_A; TIGR02630 595496010728 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 595496010729 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 595496010730 putative ligand binding site [chemical binding]; other site 595496010731 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 595496010732 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 595496010733 Walker A/P-loop; other site 595496010734 ATP binding site [chemical binding]; other site 595496010735 Q-loop/lid; other site 595496010736 ABC transporter signature motif; other site 595496010737 Walker B; other site 595496010738 D-loop; other site 595496010739 H-loop/switch region; other site 595496010740 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 595496010741 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 595496010742 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 595496010743 TM-ABC transporter signature motif; other site 595496010744 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 595496010745 putative dimerization interface [polypeptide binding]; other site 595496010746 Transcriptional regulators [Transcription]; Region: PurR; COG1609 595496010747 putative ligand binding site [chemical binding]; other site 595496010748 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 595496010749 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 595496010750 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 595496010751 hypothetical protein; Provisional; Region: PRK10356 595496010752 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 595496010753 alpha-amylase; Reviewed; Region: malS; PRK09505 595496010754 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 595496010755 active site 595496010756 catalytic site [active] 595496010757 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 595496010758 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 595496010759 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496010760 homodimer interface [polypeptide binding]; other site 595496010761 catalytic residue [active] 595496010762 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 595496010763 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 595496010764 Transcriptional regulator [Transcription]; Region: IclR; COG1414 595496010765 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 595496010766 Bacterial transcriptional regulator; Region: IclR; pfam01614 595496010767 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 595496010768 uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022 595496010769 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 595496010770 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 595496010771 DctM-like transporters; Region: DctM; pfam06808 595496010772 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 595496010773 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 595496010774 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 595496010775 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 595496010776 putative N- and C-terminal domain interface [polypeptide binding]; other site 595496010777 putative active site [active] 595496010778 MgATP binding site [chemical binding]; other site 595496010779 catalytic site [active] 595496010780 metal binding site [ion binding]; metal-binding site 595496010781 putative xylulose binding site [chemical binding]; other site 595496010782 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 595496010783 active site 595496010784 dimer interface [polypeptide binding]; other site 595496010785 magnesium binding site [ion binding]; other site 595496010786 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 595496010787 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 595496010788 AP (apurinic/apyrimidinic) site pocket; other site 595496010789 DNA interaction; other site 595496010790 Metal-binding active site; metal-binding site 595496010791 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 595496010792 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 595496010793 intersubunit interface [polypeptide binding]; other site 595496010794 active site 595496010795 Zn2+ binding site [ion binding]; other site 595496010796 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 595496010797 Transcriptional regulator [Transcription]; Region: LysR; COG0583 595496010798 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496010799 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 595496010800 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 595496010801 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 595496010802 HlyD family secretion protein; Region: HlyD_3; pfam13437 595496010803 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 595496010804 FlxA-like protein; Region: FlxA; pfam14282 595496010805 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 595496010806 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 595496010807 NAD(P) binding site [chemical binding]; other site 595496010808 catalytic residues [active] 595496010809 putative alcohol dehydrogenase; Provisional; Region: PRK09860 595496010810 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 595496010811 dimer interface [polypeptide binding]; other site 595496010812 active site 595496010813 metal binding site [ion binding]; metal-binding site 595496010814 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 595496010815 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 595496010816 G1 box; other site 595496010817 putative GEF interaction site [polypeptide binding]; other site 595496010818 GTP/Mg2+ binding site [chemical binding]; other site 595496010819 Switch I region; other site 595496010820 G2 box; other site 595496010821 G3 box; other site 595496010822 Switch II region; other site 595496010823 G4 box; other site 595496010824 G5 box; other site 595496010825 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 595496010826 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 595496010827 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 595496010828 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 595496010829 selenocysteine synthase; Provisional; Region: PRK04311 595496010830 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 595496010831 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 595496010832 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 595496010833 catalytic residue [active] 595496010834 putative glutathione S-transferase; Provisional; Region: PRK10357 595496010835 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 595496010836 putative C-terminal domain interface [polypeptide binding]; other site 595496010837 putative GSH binding site (G-site) [chemical binding]; other site 595496010838 putative dimer interface [polypeptide binding]; other site 595496010839 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 595496010840 dimer interface [polypeptide binding]; other site 595496010841 N-terminal domain interface [polypeptide binding]; other site 595496010842 putative substrate binding pocket (H-site) [chemical binding]; other site 595496010843 PAAR motif; Region: PAAR_motif; cl15808 595496010844 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 595496010845 RHS Repeat; Region: RHS_repeat; pfam05593 595496010846 RHS Repeat; Region: RHS_repeat; pfam05593 595496010847 RHS Repeat; Region: RHS_repeat; pfam05593 595496010848 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 595496010849 RHS Repeat; Region: RHS_repeat; pfam05593 595496010850 RHS Repeat; Region: RHS_repeat; pfam05593 595496010851 RHS protein; Region: RHS; pfam03527 595496010852 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 595496010853 putative lyase; Provisional; Region: PRK09687 595496010854 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 595496010855 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 595496010856 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 595496010857 HlyD family secretion protein; Region: HlyD_3; pfam13437 595496010858 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 595496010859 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 595496010860 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 595496010861 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 595496010862 active site 595496010863 P-loop; other site 595496010864 phosphorylation site [posttranslational modification] 595496010865 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 595496010866 active site 595496010867 phosphorylation site [posttranslational modification] 595496010868 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 595496010869 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 595496010870 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 595496010871 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 595496010872 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 595496010873 hypothetical protein; Provisional; Region: PRK11020 595496010874 L-lactate permease; Provisional; Region: PRK10420 595496010875 glycolate transporter; Provisional; Region: PRK09695 595496010876 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 595496010877 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 595496010878 DNA-binding site [nucleotide binding]; DNA binding site 595496010879 FCD domain; Region: FCD; pfam07729 595496010880 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 595496010881 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 595496010882 phosphate binding site [ion binding]; other site 595496010883 putative rRNA methylase; Provisional; Region: PRK10358 595496010884 serine acetyltransferase; Provisional; Region: cysE; PRK11132 595496010885 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 595496010886 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 595496010887 trimer interface [polypeptide binding]; other site 595496010888 active site 595496010889 substrate binding site [chemical binding]; other site 595496010890 CoA binding site [chemical binding]; other site 595496010891 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 595496010892 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 595496010893 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 595496010894 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 595496010895 SecA binding site; other site 595496010896 Preprotein binding site; other site 595496010897 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 595496010898 GSH binding site [chemical binding]; other site 595496010899 catalytic residues [active] 595496010900 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 595496010901 active site residue [active] 595496010902 phosphoglyceromutase; Provisional; Region: PRK05434 595496010903 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 595496010904 AmiB activator; Provisional; Region: PRK11637 595496010905 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 595496010906 Peptidase family M23; Region: Peptidase_M23; pfam01551 595496010907 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 595496010908 NodB motif; other site 595496010909 putative active site [active] 595496010910 putative catalytic site [active] 595496010911 Zn binding site [ion binding]; other site 595496010912 putative glycosyl transferase; Provisional; Region: PRK10073 595496010913 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 595496010914 active site 595496010915 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 595496010916 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 595496010917 NAD(P) binding site [chemical binding]; other site 595496010918 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 595496010919 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 595496010920 substrate-cofactor binding pocket; other site 595496010921 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496010922 catalytic residue [active] 595496010923 hypothetical protein; Provisional; Region: PRK11346 595496010924 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 595496010925 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 595496010926 NADP binding site [chemical binding]; other site 595496010927 homopentamer interface [polypeptide binding]; other site 595496010928 substrate binding site [chemical binding]; other site 595496010929 active site 595496010930 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 595496010931 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 595496010932 putative active site [active] 595496010933 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 595496010934 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 595496010935 putative active site [active] 595496010936 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 595496010937 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 595496010938 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 595496010939 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 595496010940 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 595496010941 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10359 595496010942 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 595496010943 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 595496010944 Ligand binding site; other site 595496010945 metal-binding site 595496010946 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 595496010947 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 595496010948 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 595496010949 Ligand binding site; other site 595496010950 metal-binding site 595496010951 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 595496010952 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922 595496010953 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 595496010954 putative ADP-binding pocket [chemical binding]; other site 595496010955 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 595496010956 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 595496010957 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 595496010958 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 595496010959 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 595496010960 putative active site [active] 595496010961 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 595496010962 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 595496010963 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 595496010964 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 595496010965 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 595496010966 active site 595496010967 (T/H)XGH motif; other site 595496010968 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 595496010969 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 595496010970 DNA binding site [nucleotide binding] 595496010971 catalytic residue [active] 595496010972 H2TH interface [polypeptide binding]; other site 595496010973 putative catalytic residues [active] 595496010974 turnover-facilitating residue; other site 595496010975 intercalation triad [nucleotide binding]; other site 595496010976 8OG recognition residue [nucleotide binding]; other site 595496010977 putative reading head residues; other site 595496010978 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 595496010979 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 595496010980 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 595496010981 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 595496010982 hypothetical protein; Reviewed; Region: PRK00024 595496010983 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 595496010984 MPN+ (JAMM) motif; other site 595496010985 Zinc-binding site [ion binding]; other site 595496010986 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 595496010987 Flavoprotein; Region: Flavoprotein; pfam02441 595496010988 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 595496010989 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 595496010990 trimer interface [polypeptide binding]; other site 595496010991 active site 595496010992 division inhibitor protein; Provisional; Region: slmA; PRK09480 595496010993 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 595496010994 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 595496010995 active site 595496010996 ribonuclease PH; Reviewed; Region: rph; PRK00173 595496010997 Ribonuclease PH; Region: RNase_PH_bact; cd11362 595496010998 hexamer interface [polypeptide binding]; other site 595496010999 active site 595496011000 hypothetical protein; Provisional; Region: PRK11820 595496011001 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 595496011002 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 595496011003 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 595496011004 BRO family, N-terminal domain; Region: Bro-N; pfam02498 595496011005 Predicted membrane protein [Function unknown]; Region: COG2860 595496011006 UPF0126 domain; Region: UPF0126; pfam03458 595496011007 UPF0126 domain; Region: UPF0126; pfam03458 595496011008 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 595496011009 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 595496011010 nucleotide binding pocket [chemical binding]; other site 595496011011 K-X-D-G motif; other site 595496011012 catalytic site [active] 595496011013 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 595496011014 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 595496011015 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 595496011016 catalytic site [active] 595496011017 G-X2-G-X-G-K; other site 595496011018 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 595496011019 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 595496011020 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 595496011021 Zn2+ binding site [ion binding]; other site 595496011022 Mg2+ binding site [ion binding]; other site 595496011023 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 595496011024 synthetase active site [active] 595496011025 NTP binding site [chemical binding]; other site 595496011026 metal binding site [ion binding]; metal-binding site 595496011027 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 595496011028 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 595496011029 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 595496011030 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 595496011031 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 595496011032 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 595496011033 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 595496011034 generic binding surface II; other site 595496011035 ssDNA binding site; other site 595496011036 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 595496011037 ATP binding site [chemical binding]; other site 595496011038 putative Mg++ binding site [ion binding]; other site 595496011039 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 595496011040 nucleotide binding region [chemical binding]; other site 595496011041 ATP-binding site [chemical binding]; other site 595496011042 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 595496011043 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 595496011044 AsmA family; Region: AsmA; pfam05170 595496011045 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 595496011046 putative alpha-glucosidase; Provisional; Region: PRK10658 595496011047 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 595496011048 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 595496011049 active site 595496011050 homotrimer interface [polypeptide binding]; other site 595496011051 catalytic site [active] 595496011052 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 595496011053 putative transporter; Provisional; Region: PRK11462 595496011054 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 595496011055 sugar efflux transporter; Region: 2A0120; TIGR00899 595496011056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496011057 putative substrate translocation pore; other site 595496011058 EamA-like transporter family; Region: EamA; pfam00892 595496011059 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 595496011060 EamA-like transporter family; Region: EamA; pfam00892 595496011061 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 595496011062 lipoprotein, YaeC family; Region: TIGR00363 595496011063 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 595496011064 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 595496011065 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496011066 putative substrate translocation pore; other site 595496011067 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 595496011068 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 595496011069 cryptic adenine deaminase; Provisional; Region: PRK10027 595496011070 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 595496011071 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 595496011072 active site 595496011073 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 595496011074 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 595496011075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496011076 putative substrate translocation pore; other site 595496011077 regulatory protein UhpC; Provisional; Region: PRK11663 595496011078 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496011079 putative substrate translocation pore; other site 595496011080 sensory histidine kinase UhpB; Provisional; Region: PRK11644 595496011081 MASE1; Region: MASE1; pfam05231 595496011082 Histidine kinase; Region: HisKA_3; pfam07730 595496011083 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 595496011084 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 595496011085 active site 595496011086 phosphorylation site [posttranslational modification] 595496011087 intermolecular recognition site; other site 595496011088 dimerization interface [polypeptide binding]; other site 595496011089 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 595496011090 DNA binding residues [nucleotide binding] 595496011091 dimerization interface [polypeptide binding]; other site 595496011092 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 595496011093 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 595496011094 putative valine binding site [chemical binding]; other site 595496011095 dimer interface [polypeptide binding]; other site 595496011096 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 595496011097 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 595496011098 PYR/PP interface [polypeptide binding]; other site 595496011099 dimer interface [polypeptide binding]; other site 595496011100 TPP binding site [chemical binding]; other site 595496011101 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 595496011102 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 595496011103 TPP-binding site [chemical binding]; other site 595496011104 dimer interface [polypeptide binding]; other site 595496011105 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 595496011106 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496011107 putative substrate translocation pore; other site 595496011108 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 595496011109 Domain of unknown function (DUF202); Region: DUF202; pfam02656 595496011110 Predicted membrane protein [Function unknown]; Region: COG2149 595496011111 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 595496011112 Sulfatase; Region: Sulfatase; pfam00884 595496011113 putative transporter; Provisional; Region: PRK10484 595496011114 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 595496011115 Na binding site [ion binding]; other site 595496011116 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 595496011117 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 595496011118 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 595496011119 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 595496011120 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 595496011121 DNA-binding site [nucleotide binding]; DNA binding site 595496011122 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 595496011123 putative transporter; Validated; Region: PRK03818 595496011124 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 595496011125 TrkA-C domain; Region: TrkA_C; pfam02080 595496011126 TrkA-C domain; Region: TrkA_C; pfam02080 595496011127 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 595496011128 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 595496011129 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 595496011130 putative dimer interface [polypeptide binding]; other site 595496011131 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 595496011132 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 595496011133 putative dimer interface [polypeptide binding]; other site 595496011134 hypothetical protein; Provisional; Region: PRK11616 595496011135 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 595496011136 putative oxidoreductase; Provisional; Region: PRK11445 595496011137 hypothetical protein; Provisional; Region: PRK07236 595496011138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496011139 D-galactonate transporter; Region: 2A0114; TIGR00893 595496011140 putative substrate translocation pore; other site 595496011141 galactonate dehydratase; Provisional; Region: PRK14017 595496011142 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 595496011143 putative active site pocket [active] 595496011144 putative metal binding site [ion binding]; other site 595496011145 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 595496011146 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 595496011147 active site 595496011148 intersubunit interface [polypeptide binding]; other site 595496011149 catalytic residue [active] 595496011150 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 595496011151 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 595496011152 Transcriptional regulators [Transcription]; Region: FadR; COG2186 595496011153 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 595496011154 DNA-binding site [nucleotide binding]; DNA binding site 595496011155 FCD domain; Region: FCD; pfam07729 595496011156 hypothetical protein; Provisional; Region: PRK10215 595496011157 sugar phosphate phosphatase; Provisional; Region: PRK10513 595496011158 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 595496011159 active site 595496011160 motif I; other site 595496011161 motif II; other site 595496011162 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 595496011163 hypothetical protein; Provisional; Region: PRK11426 595496011164 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 595496011165 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 595496011166 Mg2+ binding site [ion binding]; other site 595496011167 G-X-G motif; other site 595496011168 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 595496011169 anchoring element; other site 595496011170 dimer interface [polypeptide binding]; other site 595496011171 ATP binding site [chemical binding]; other site 595496011172 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 595496011173 active site 595496011174 putative metal-binding site [ion binding]; other site 595496011175 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 595496011176 recF protein; Region: recf; TIGR00611 595496011177 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 595496011178 Walker A/P-loop; other site 595496011179 ATP binding site [chemical binding]; other site 595496011180 Q-loop/lid; other site 595496011181 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 595496011182 ABC transporter signature motif; other site 595496011183 Walker B; other site 595496011184 D-loop; other site 595496011185 H-loop/switch region; other site 595496011186 DNA polymerase III subunit beta; Validated; Region: PRK05643 595496011187 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 595496011188 putative DNA binding surface [nucleotide binding]; other site 595496011189 dimer interface [polypeptide binding]; other site 595496011190 beta-clamp/clamp loader binding surface; other site 595496011191 beta-clamp/translesion DNA polymerase binding surface; other site 595496011192 DnaA N-terminal domain; Region: DnaA_N; pfam11638 595496011193 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 595496011194 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 595496011195 Walker A motif; other site 595496011196 ATP binding site [chemical binding]; other site 595496011197 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 595496011198 Walker B motif; other site 595496011199 arginine finger; other site 595496011200 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 595496011201 DnaA box-binding interface [nucleotide binding]; other site 595496011202 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 595496011203 ribonuclease P; Reviewed; Region: rnpA; PRK01732 595496011204 hypothetical protein; Validated; Region: PRK00041 595496011205 membrane protein insertase; Provisional; Region: PRK01318 595496011206 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 595496011207 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 595496011208 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 595496011209 trmE is a tRNA modification GTPase; Region: trmE; cd04164 595496011210 G1 box; other site 595496011211 GTP/Mg2+ binding site [chemical binding]; other site 595496011212 Switch I region; other site 595496011213 G2 box; other site 595496011214 Switch II region; other site 595496011215 G3 box; other site 595496011216 G4 box; other site 595496011217 G5 box; other site 595496011218 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 595496011219 Tryptophanese operon leader peptide; Region: Tna_leader; pfam08053 595496011220 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 595496011221 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 595496011222 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 595496011223 catalytic residue [active] 595496011224 tryptophan permease TnaB; Provisional; Region: PRK09664 595496011225 aromatic amino acid transport protein; Region: araaP; TIGR00837 595496011226 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 595496011227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496011228 putative substrate translocation pore; other site 595496011229 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 595496011230 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496011231 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 595496011232 substrate binding pocket [chemical binding]; other site 595496011233 dimerization interface [polypeptide binding]; other site 595496011234 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 595496011235 Predicted flavoprotein [General function prediction only]; Region: COG0431 595496011236 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 595496011237 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 595496011238 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 595496011239 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 595496011240 active site 595496011241 motif I; other site 595496011242 motif II; other site 595496011243 putative inner membrane protein; Provisional; Region: PRK09823 595496011244 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3196 595496011245 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 595496011246 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 595496011247 active site 595496011248 trimer interface [polypeptide binding]; other site 595496011249 allosteric site; other site 595496011250 active site lid [active] 595496011251 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 595496011252 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 595496011253 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 595496011254 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 595496011255 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 595496011256 trimer interface; other site 595496011257 sugar binding site [chemical binding]; other site 595496011258 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 595496011259 beta-galactosidase; Region: BGL; TIGR03356 595496011260 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 595496011261 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 595496011262 active site turn [active] 595496011263 phosphorylation site [posttranslational modification] 595496011264 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 595496011265 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 595496011266 HPr interaction site; other site 595496011267 glycerol kinase (GK) interaction site [polypeptide binding]; other site 595496011268 active site 595496011269 phosphorylation site [posttranslational modification] 595496011270 transcriptional antiterminator BglG; Provisional; Region: PRK09772 595496011271 CAT RNA binding domain; Region: CAT_RBD; pfam03123 595496011272 PRD domain; Region: PRD; pfam00874 595496011273 PRD domain; Region: PRD; pfam00874 595496011274 transcriptional regulator PhoU; Provisional; Region: PRK11115 595496011275 PhoU domain; Region: PhoU; pfam01895 595496011276 PhoU domain; Region: PhoU; pfam01895 595496011277 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 595496011278 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 595496011279 Walker A/P-loop; other site 595496011280 ATP binding site [chemical binding]; other site 595496011281 Q-loop/lid; other site 595496011282 ABC transporter signature motif; other site 595496011283 Walker B; other site 595496011284 D-loop; other site 595496011285 H-loop/switch region; other site 595496011286 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 595496011287 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496011288 dimer interface [polypeptide binding]; other site 595496011289 conserved gate region; other site 595496011290 putative PBP binding loops; other site 595496011291 ABC-ATPase subunit interface; other site 595496011292 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 595496011293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496011294 dimer interface [polypeptide binding]; other site 595496011295 conserved gate region; other site 595496011296 putative PBP binding loops; other site 595496011297 ABC-ATPase subunit interface; other site 595496011298 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 595496011299 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 595496011300 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 595496011301 glutaminase active site [active] 595496011302 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 595496011303 dimer interface [polypeptide binding]; other site 595496011304 active site 595496011305 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 595496011306 dimer interface [polypeptide binding]; other site 595496011307 active site 595496011308 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 595496011309 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 595496011310 Substrate binding site; other site 595496011311 Mg++ binding site; other site 595496011312 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 595496011313 active site 595496011314 substrate binding site [chemical binding]; other site 595496011315 CoA binding site [chemical binding]; other site 595496011316 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 595496011317 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 595496011318 gamma subunit interface [polypeptide binding]; other site 595496011319 epsilon subunit interface [polypeptide binding]; other site 595496011320 LBP interface [polypeptide binding]; other site 595496011321 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 595496011322 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 595496011323 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 595496011324 alpha subunit interaction interface [polypeptide binding]; other site 595496011325 Walker A motif; other site 595496011326 ATP binding site [chemical binding]; other site 595496011327 Walker B motif; other site 595496011328 inhibitor binding site; inhibition site 595496011329 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 595496011330 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 595496011331 core domain interface [polypeptide binding]; other site 595496011332 delta subunit interface [polypeptide binding]; other site 595496011333 epsilon subunit interface [polypeptide binding]; other site 595496011334 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 595496011335 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 595496011336 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 595496011337 beta subunit interaction interface [polypeptide binding]; other site 595496011338 Walker A motif; other site 595496011339 ATP binding site [chemical binding]; other site 595496011340 Walker B motif; other site 595496011341 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 595496011342 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 595496011343 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 595496011344 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 595496011345 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 595496011346 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 595496011347 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 595496011348 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 595496011349 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 595496011350 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 595496011351 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 595496011352 S-adenosylmethionine binding site [chemical binding]; other site 595496011353 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 595496011354 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 595496011355 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 595496011356 FMN-binding protein MioC; Provisional; Region: PRK09004 595496011357 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 595496011358 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 595496011359 putative DNA binding site [nucleotide binding]; other site 595496011360 putative Zn2+ binding site [ion binding]; other site 595496011361 AsnC family; Region: AsnC_trans_reg; pfam01037 595496011362 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 595496011363 dimer interface [polypeptide binding]; other site 595496011364 active site 595496011365 hypothetical protein; Provisional; Region: yieM; PRK10997 595496011366 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 595496011367 metal ion-dependent adhesion site (MIDAS); other site 595496011368 regulatory ATPase RavA; Provisional; Region: PRK13531 595496011369 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 595496011370 Walker A motif; other site 595496011371 ATP binding site [chemical binding]; other site 595496011372 Walker B motif; other site 595496011373 arginine finger; other site 595496011374 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 595496011375 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 595496011376 potassium uptake protein; Region: kup; TIGR00794 595496011377 D-ribose pyranase; Provisional; Region: PRK11797 595496011378 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 595496011379 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 595496011380 Walker A/P-loop; other site 595496011381 ATP binding site [chemical binding]; other site 595496011382 Q-loop/lid; other site 595496011383 ABC transporter signature motif; other site 595496011384 Walker B; other site 595496011385 D-loop; other site 595496011386 H-loop/switch region; other site 595496011387 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 595496011388 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 595496011389 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 595496011390 TM-ABC transporter signature motif; other site 595496011391 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 595496011392 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 595496011393 ligand binding site [chemical binding]; other site 595496011394 dimerization interface [polypeptide binding]; other site 595496011395 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 595496011396 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 595496011397 substrate binding site [chemical binding]; other site 595496011398 dimer interface [polypeptide binding]; other site 595496011399 ATP binding site [chemical binding]; other site 595496011400 IS2 repressor TnpA; Reviewed; Region: PRK09413 595496011401 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 595496011402 IS2 transposase TnpB; Reviewed; Region: PRK09409 595496011403 HTH-like domain; Region: HTH_21; pfam13276 595496011404 Integrase core domain; Region: rve; pfam00665 595496011405 Integrase core domain; Region: rve_3; pfam13683 595496011406 putative transporter; Provisional; Region: PRK10504 595496011407 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496011408 putative substrate translocation pore; other site 595496011409 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496011410 Transcriptional regulators [Transcription]; Region: FadR; COG2186 595496011411 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 595496011412 DNA-binding site [nucleotide binding]; DNA binding site 595496011413 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 595496011414 transcriptional regulator HdfR; Provisional; Region: PRK03601 595496011415 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496011416 LysR substrate binding domain; Region: LysR_substrate; pfam03466 595496011417 dimerization interface [polypeptide binding]; other site 595496011418 hypothetical protein; Provisional; Region: PRK11027 595496011419 putative ATP-dependent protease; Provisional; Region: PRK09862 595496011420 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 595496011421 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 595496011422 Walker A motif; other site 595496011423 ATP binding site [chemical binding]; other site 595496011424 Walker B motif; other site 595496011425 arginine finger; other site 595496011426 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 595496011427 ilvG operon leader peptide; Provisional; Region: PRK10424 595496011428 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 595496011429 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 595496011430 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 595496011431 homodimer interface [polypeptide binding]; other site 595496011432 substrate-cofactor binding pocket; other site 595496011433 catalytic residue [active] 595496011434 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 595496011435 threonine dehydratase; Reviewed; Region: PRK09224 595496011436 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 595496011437 tetramer interface [polypeptide binding]; other site 595496011438 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496011439 catalytic residue [active] 595496011440 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 595496011441 putative Ile/Val binding site [chemical binding]; other site 595496011442 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 595496011443 putative Ile/Val binding site [chemical binding]; other site 595496011444 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496011445 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 595496011446 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 595496011447 putative dimerization interface [polypeptide binding]; other site 595496011448 ketol-acid reductoisomerase; Validated; Region: PRK05225 595496011449 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 595496011450 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 595496011451 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 595496011452 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 595496011453 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 595496011454 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 595496011455 Part of AAA domain; Region: AAA_19; pfam13245 595496011456 Family description; Region: UvrD_C_2; pfam13538 595496011457 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 595496011458 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 595496011459 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 595496011460 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 595496011461 ATP binding site [chemical binding]; other site 595496011462 Mg++ binding site [ion binding]; other site 595496011463 motif III; other site 595496011464 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 595496011465 nucleotide binding region [chemical binding]; other site 595496011466 ATP-binding site [chemical binding]; other site 595496011467 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 595496011468 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 595496011469 catalytic residues [active] 595496011470 transcription termination factor Rho; Provisional; Region: rho; PRK09376 595496011471 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 595496011472 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 595496011473 RNA binding site [nucleotide binding]; other site 595496011474 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 595496011475 multimer interface [polypeptide binding]; other site 595496011476 Walker A motif; other site 595496011477 ATP binding site [chemical binding]; other site 595496011478 Walker B motif; other site 595496011479 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 595496011480 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 595496011481 Mg++ binding site [ion binding]; other site 595496011482 putative catalytic motif [active] 595496011483 substrate binding site [chemical binding]; other site 595496011484 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 595496011485 Chain length determinant protein; Region: Wzz; pfam02706 595496011486 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 595496011487 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 595496011488 active site 595496011489 homodimer interface [polypeptide binding]; other site 595496011490 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 595496011491 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 595496011492 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 595496011493 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 595496011494 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 595496011495 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 595496011496 NAD binding site [chemical binding]; other site 595496011497 substrate binding site [chemical binding]; other site 595496011498 homodimer interface [polypeptide binding]; other site 595496011499 active site 595496011500 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 595496011501 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 595496011502 substrate binding site; other site 595496011503 tetramer interface; other site 595496011504 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 595496011505 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 595496011506 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 595496011507 inhibitor-cofactor binding pocket; inhibition site 595496011508 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496011509 catalytic residue [active] 595496011510 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 595496011511 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 595496011512 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 595496011513 putative common antigen polymerase; Provisional; Region: PRK02975 595496011514 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 595496011515 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 595496011516 putative transport protein YifK; Provisional; Region: PRK10746 595496011517 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 595496011518 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 595496011519 FeS/SAM binding site; other site 595496011520 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 595496011521 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 595496011522 Sulfatase; Region: Sulfatase; pfam00884 595496011523 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 595496011524 HemY protein N-terminus; Region: HemY_N; pfam07219 595496011525 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 595496011526 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 595496011527 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 595496011528 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 595496011529 active site 595496011530 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 595496011531 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 595496011532 domain interfaces; other site 595496011533 active site 595496011534 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 595496011535 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 595496011536 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 595496011537 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 595496011538 putative iron binding site [ion binding]; other site 595496011539 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 595496011540 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 595496011541 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 595496011542 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 595496011543 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 595496011544 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 595496011545 active site 595496011546 DNA binding site [nucleotide binding] 595496011547 Int/Topo IB signature motif; other site 595496011548 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 595496011549 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 595496011550 motif II; other site 595496011551 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 595496011552 Part of AAA domain; Region: AAA_19; pfam13245 595496011553 Family description; Region: UvrD_C_2; pfam13538 595496011554 Predicted periplasmic protein [Function unknown]; Region: COG3698 595496011555 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 595496011556 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 595496011557 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 595496011558 Cl binding site [ion binding]; other site 595496011559 oligomer interface [polypeptide binding]; other site 595496011560 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 595496011561 hypothetical protein; Provisional; Region: PRK11371 595496011562 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 595496011563 EamA-like transporter family; Region: EamA; cl17759 595496011564 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 595496011565 CoenzymeA binding site [chemical binding]; other site 595496011566 subunit interaction site [polypeptide binding]; other site 595496011567 PHB binding site; other site 595496011568 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 595496011569 dimerization interface [polypeptide binding]; other site 595496011570 substrate binding site [chemical binding]; other site 595496011571 active site 595496011572 calcium binding site [ion binding]; other site 595496011573 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 595496011574 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 595496011575 ATP binding site [chemical binding]; other site 595496011576 putative Mg++ binding site [ion binding]; other site 595496011577 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 595496011578 nucleotide binding region [chemical binding]; other site 595496011579 ATP-binding site [chemical binding]; other site 595496011580 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 595496011581 Helicase and RNase D C-terminal; Region: HRDC; smart00341 595496011582 threonine efflux system; Provisional; Region: PRK10229 595496011583 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 595496011584 lysophospholipase L2; Provisional; Region: PRK10749 595496011585 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 595496011586 putative hydrolase; Provisional; Region: PRK10976 595496011587 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 595496011588 active site 595496011589 motif I; other site 595496011590 motif II; other site 595496011591 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 595496011592 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 595496011593 EamA-like transporter family; Region: EamA; pfam00892 595496011594 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 595496011595 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496011596 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 595496011597 putative dimerization interface [polypeptide binding]; other site 595496011598 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 595496011599 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 595496011600 THF binding site; other site 595496011601 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 595496011602 substrate binding site [chemical binding]; other site 595496011603 THF binding site; other site 595496011604 zinc-binding site [ion binding]; other site 595496011605 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 595496011606 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 595496011607 uridine phosphorylase; Provisional; Region: PRK11178 595496011608 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 595496011609 DNA recombination protein RmuC; Provisional; Region: PRK10361 595496011610 RmuC family; Region: RmuC; pfam02646 595496011611 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 595496011612 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 595496011613 S-adenosylmethionine binding site [chemical binding]; other site 595496011614 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 595496011615 SCP-2 sterol transfer family; Region: SCP2; pfam02036 595496011616 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 595496011617 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 595496011618 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 595496011619 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 595496011620 sec-independent translocase; Provisional; Region: PRK01770 595496011621 sec-independent translocase; Provisional; Region: tatB; PRK00404 595496011622 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 595496011623 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 595496011624 active site 595496011625 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 595496011626 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 595496011627 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 595496011628 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 595496011629 FMN reductase; Validated; Region: fre; PRK08051 595496011630 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 595496011631 FAD binding pocket [chemical binding]; other site 595496011632 FAD binding motif [chemical binding]; other site 595496011633 phosphate binding motif [ion binding]; other site 595496011634 beta-alpha-beta structure motif; other site 595496011635 NAD binding pocket [chemical binding]; other site 595496011636 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 595496011637 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 595496011638 dimer interface [polypeptide binding]; other site 595496011639 active site 595496011640 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 595496011641 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 595496011642 substrate binding site [chemical binding]; other site 595496011643 oxyanion hole (OAH) forming residues; other site 595496011644 trimer interface [polypeptide binding]; other site 595496011645 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 595496011646 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 595496011647 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 595496011648 proline dipeptidase; Provisional; Region: PRK13607 595496011649 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 595496011650 active site 595496011651 hypothetical protein; Provisional; Region: PRK11568 595496011652 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 595496011653 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 595496011654 potassium transporter; Provisional; Region: PRK10750 595496011655 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 595496011656 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 595496011657 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 595496011658 Walker A motif; other site 595496011659 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 595496011660 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 595496011661 GTP binding site; other site 595496011662 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 595496011663 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 595496011664 serine/threonine protein kinase; Provisional; Region: PRK11768 595496011665 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 595496011666 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 595496011667 catalytic residues [active] 595496011668 hinge region; other site 595496011669 alpha helical domain; other site 595496011670 hypothetical protein; Provisional; Region: PRK11367 595496011671 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 595496011672 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 595496011673 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 595496011674 putative acyl-acceptor binding pocket; other site 595496011675 DNA polymerase I; Provisional; Region: PRK05755 595496011676 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 595496011677 active site 595496011678 metal binding site 1 [ion binding]; metal-binding site 595496011679 putative 5' ssDNA interaction site; other site 595496011680 metal binding site 3; metal-binding site 595496011681 metal binding site 2 [ion binding]; metal-binding site 595496011682 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 595496011683 putative DNA binding site [nucleotide binding]; other site 595496011684 putative metal binding site [ion binding]; other site 595496011685 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 595496011686 active site 595496011687 catalytic site [active] 595496011688 substrate binding site [chemical binding]; other site 595496011689 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 595496011690 active site 595496011691 DNA binding site [nucleotide binding] 595496011692 catalytic site [active] 595496011693 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 595496011694 G1 box; other site 595496011695 GTP/Mg2+ binding site [chemical binding]; other site 595496011696 Switch I region; other site 595496011697 G2 box; other site 595496011698 G3 box; other site 595496011699 Switch II region; other site 595496011700 G4 box; other site 595496011701 G5 box; other site 595496011702 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 595496011703 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 595496011704 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 595496011705 FeS/SAM binding site; other site 595496011706 HemN C-terminal domain; Region: HemN_C; pfam06969 595496011707 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 595496011708 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 595496011709 active site 595496011710 phosphorylation site [posttranslational modification] 595496011711 intermolecular recognition site; other site 595496011712 dimerization interface [polypeptide binding]; other site 595496011713 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 595496011714 Walker A motif; other site 595496011715 ATP binding site [chemical binding]; other site 595496011716 Walker B motif; other site 595496011717 arginine finger; other site 595496011718 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 595496011719 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 595496011720 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 595496011721 putative active site [active] 595496011722 heme pocket [chemical binding]; other site 595496011723 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 595496011724 dimer interface [polypeptide binding]; other site 595496011725 phosphorylation site [posttranslational modification] 595496011726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 595496011727 ATP binding site [chemical binding]; other site 595496011728 Mg2+ binding site [ion binding]; other site 595496011729 G-X-G motif; other site 595496011730 glutamine synthetase; Provisional; Region: glnA; PRK09469 595496011731 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 595496011732 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 595496011733 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 595496011734 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 595496011735 G1 box; other site 595496011736 putative GEF interaction site [polypeptide binding]; other site 595496011737 GTP/Mg2+ binding site [chemical binding]; other site 595496011738 Switch I region; other site 595496011739 G2 box; other site 595496011740 G3 box; other site 595496011741 Switch II region; other site 595496011742 G4 box; other site 595496011743 G5 box; other site 595496011744 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 595496011745 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 595496011746 transcriptional regulator protein; Region: phnR; TIGR03337 595496011747 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 595496011748 DNA-binding site [nucleotide binding]; DNA binding site 595496011749 UTRA domain; Region: UTRA; pfam07702 595496011750 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 595496011751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496011752 putative substrate translocation pore; other site 595496011753 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 595496011754 outer membrane porin L; Provisional; Region: ompL; PRK09980 595496011755 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 595496011756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496011757 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 595496011758 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 595496011759 alpha-glucosidase; Provisional; Region: PRK10426 595496011760 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 595496011761 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 595496011762 putative active site [active] 595496011763 putative catalytic site [active] 595496011764 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 595496011765 active site 595496011766 catalytic residues [active] 595496011767 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 595496011768 dimerization interface [polypeptide binding]; other site 595496011769 putative active cleft [active] 595496011770 Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684 595496011771 catalytic residue [active] 595496011772 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 595496011773 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 595496011774 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 595496011775 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 595496011776 substrate binding site [chemical binding]; other site 595496011777 ATP binding site [chemical binding]; other site 595496011778 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 595496011779 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 595496011780 putative DNA binding site [nucleotide binding]; other site 595496011781 putative Zn2+ binding site [ion binding]; other site 595496011782 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 595496011783 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 595496011784 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 595496011785 motif II; other site 595496011786 hypothetical protein; Reviewed; Region: PRK01637 595496011787 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 595496011788 putative active site [active] 595496011789 dimerization interface [polypeptide binding]; other site 595496011790 putative tRNAtyr binding site [nucleotide binding]; other site 595496011791 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 595496011792 Coenzyme A binding pocket [chemical binding]; other site 595496011793 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 595496011794 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 595496011795 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 595496011796 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 595496011797 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 595496011798 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 595496011799 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 595496011800 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 595496011801 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 595496011802 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 595496011803 [4Fe-4S] binding site [ion binding]; other site 595496011804 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 595496011805 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 595496011806 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 595496011807 molybdopterin cofactor binding site; other site 595496011808 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 595496011809 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 595496011810 putative frv operon regulatory protein; Provisional; Region: PRK09863 595496011811 HTH domain; Region: HTH_11; pfam08279 595496011812 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 595496011813 active site 595496011814 phosphorylation site [posttranslational modification] 595496011815 putative peptidase; Provisional; Region: PRK09864 595496011816 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 595496011817 oligomer interface [polypeptide binding]; other site 595496011818 active site 595496011819 metal binding site [ion binding]; metal-binding site 595496011820 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 595496011821 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 595496011822 active site 595496011823 P-loop; other site 595496011824 phosphorylation site [posttranslational modification] 595496011825 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 595496011826 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 595496011827 active site 595496011828 phosphorylation site [posttranslational modification] 595496011829 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 595496011830 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 595496011831 intersubunit interface [polypeptide binding]; other site 595496011832 active site 595496011833 Zn2+ binding site [ion binding]; other site 595496011834 L-rhamnose isomerase; Provisional; Region: PRK01076 595496011835 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 595496011836 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 595496011837 N- and C-terminal domain interface [polypeptide binding]; other site 595496011838 active site 595496011839 putative catalytic site [active] 595496011840 metal binding site [ion binding]; metal-binding site 595496011841 ATP binding site [chemical binding]; other site 595496011842 rhamnulokinase; Provisional; Region: rhaB; PRK10640 595496011843 carbohydrate binding site [chemical binding]; other site 595496011844 transcriptional activator RhaS; Provisional; Region: PRK13503 595496011845 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 595496011846 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 595496011847 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 595496011848 transcriptional activator RhaR; Provisional; Region: PRK13500 595496011849 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 595496011850 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 595496011851 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 595496011852 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 595496011853 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 595496011854 superoxide dismutase; Provisional; Region: PRK10925 595496011855 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 595496011856 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 595496011857 2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793 595496011858 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 595496011859 MOSC domain; Region: MOSC; pfam03473 595496011860 3-alpha domain; Region: 3-alpha; pfam03475 595496011861 two-component sensor protein; Provisional; Region: cpxA; PRK09470 595496011862 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 595496011863 dimerization interface [polypeptide binding]; other site 595496011864 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 595496011865 dimer interface [polypeptide binding]; other site 595496011866 phosphorylation site [posttranslational modification] 595496011867 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 595496011868 ATP binding site [chemical binding]; other site 595496011869 Mg2+ binding site [ion binding]; other site 595496011870 G-X-G motif; other site 595496011871 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 595496011872 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 595496011873 active site 595496011874 intermolecular recognition site; other site 595496011875 dimerization interface [polypeptide binding]; other site 595496011876 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 595496011877 DNA binding site [nucleotide binding] 595496011878 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 595496011879 dimer interface [polypeptide binding]; other site 595496011880 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 595496011881 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 595496011882 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 595496011883 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 595496011884 active site 595496011885 ADP/pyrophosphate binding site [chemical binding]; other site 595496011886 dimerization interface [polypeptide binding]; other site 595496011887 allosteric effector site; other site 595496011888 fructose-1,6-bisphosphate binding site; other site 595496011889 sulfate transporter subunit; Provisional; Region: PRK10752 595496011890 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 595496011891 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 595496011892 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 595496011893 triosephosphate isomerase; Provisional; Region: PRK14567 595496011894 substrate binding site [chemical binding]; other site 595496011895 dimer interface [polypeptide binding]; other site 595496011896 catalytic triad [active] 595496011897 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 595496011898 Predicted membrane protein [Function unknown]; Region: COG3152 595496011899 hypothetical protein; Provisional; Region: PRK09981 595496011900 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 595496011901 Ligand Binding Site [chemical binding]; other site 595496011902 ferredoxin-NADP reductase; Provisional; Region: PRK10926 595496011903 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 595496011904 FAD binding pocket [chemical binding]; other site 595496011905 FAD binding motif [chemical binding]; other site 595496011906 phosphate binding motif [ion binding]; other site 595496011907 beta-alpha-beta structure motif; other site 595496011908 NAD binding pocket [chemical binding]; other site 595496011909 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 595496011910 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 595496011911 putative active site [active] 595496011912 glycerol kinase; Provisional; Region: glpK; PRK00047 595496011913 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 595496011914 N- and C-terminal domain interface [polypeptide binding]; other site 595496011915 active site 595496011916 MgATP binding site [chemical binding]; other site 595496011917 catalytic site [active] 595496011918 metal binding site [ion binding]; metal-binding site 595496011919 glycerol binding site [chemical binding]; other site 595496011920 homotetramer interface [polypeptide binding]; other site 595496011921 homodimer interface [polypeptide binding]; other site 595496011922 FBP binding site [chemical binding]; other site 595496011923 protein IIAGlc interface [polypeptide binding]; other site 595496011924 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 595496011925 amphipathic channel; other site 595496011926 Asn-Pro-Ala signature motifs; other site 595496011927 septal ring assembly protein ZapB; Provisional; Region: PRK15422 595496011928 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 595496011929 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 595496011930 UbiA prenyltransferase family; Region: UbiA; pfam01040 595496011931 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 595496011932 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 595496011933 Walker A motif; other site 595496011934 ATP binding site [chemical binding]; other site 595496011935 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 595496011936 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 595496011937 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 595496011938 active site 595496011939 HslU subunit interaction site [polypeptide binding]; other site 595496011940 essential cell division protein FtsN; Provisional; Region: PRK10927 595496011941 cell division protein FtsN; Provisional; Region: PRK12757 595496011942 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 595496011943 DNA binding site [nucleotide binding] 595496011944 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 595496011945 domain linker motif; other site 595496011946 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 595496011947 dimerization interface [polypeptide binding]; other site 595496011948 ligand binding site [chemical binding]; other site 595496011949 primosome assembly protein PriA; Validated; Region: PRK05580 595496011950 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 595496011951 ATP binding site [chemical binding]; other site 595496011952 putative Mg++ binding site [ion binding]; other site 595496011953 helicase superfamily c-terminal domain; Region: HELICc; smart00490 595496011954 ATP-binding site [chemical binding]; other site 595496011955 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 595496011956 hypothetical protein; Provisional; Region: PRK10030 595496011957 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 595496011958 dimerization interface [polypeptide binding]; other site 595496011959 DNA binding site [nucleotide binding] 595496011960 corepressor binding sites; other site 595496011961 cystathionine gamma-synthase; Provisional; Region: PRK08045 595496011962 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 595496011963 homodimer interface [polypeptide binding]; other site 595496011964 substrate-cofactor binding pocket; other site 595496011965 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496011966 catalytic residue [active] 595496011967 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 595496011968 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 595496011969 putative catalytic residues [active] 595496011970 putative nucleotide binding site [chemical binding]; other site 595496011971 putative aspartate binding site [chemical binding]; other site 595496011972 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 595496011973 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 595496011974 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 595496011975 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 595496011976 FAD binding site [chemical binding]; other site 595496011977 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 595496011978 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 595496011979 heme binding site [chemical binding]; other site 595496011980 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 595496011981 EamA-like transporter family; Region: EamA; pfam00892 595496011982 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 595496011983 EamA-like transporter family; Region: EamA; pfam00892 595496011984 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 595496011985 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 595496011986 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 595496011987 dimer interface [polypeptide binding]; other site 595496011988 active site 595496011989 metal binding site [ion binding]; metal-binding site 595496011990 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 595496011991 active site 595496011992 intersubunit interactions; other site 595496011993 catalytic residue [active] 595496011994 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 595496011995 dimerization domain swap beta strand [polypeptide binding]; other site 595496011996 regulatory protein interface [polypeptide binding]; other site 595496011997 active site 595496011998 regulatory phosphorylation site [posttranslational modification]; other site 595496011999 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 595496012000 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 595496012001 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 595496012002 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 595496012003 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 595496012004 active site 595496012005 phosphorylation site [posttranslational modification] 595496012006 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 595496012007 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 595496012008 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 595496012009 active site 595496012010 P-loop; other site 595496012011 phosphorylation site [posttranslational modification] 595496012012 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 595496012013 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 595496012014 dimer interface [polypeptide binding]; other site 595496012015 active site 595496012016 glycine loop; other site 595496012017 pyruvate formate lyase II activase; Provisional; Region: PRK10076 595496012018 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 595496012019 active site 595496012020 P-loop; other site 595496012021 phosphorylation site [posttranslational modification] 595496012022 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 595496012023 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 595496012024 hypothetical protein; Provisional; Region: PRK10649 595496012025 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 595496012026 Sulfatase; Region: Sulfatase; pfam00884 595496012027 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 595496012028 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 595496012029 acetylornithine deacetylase; Provisional; Region: PRK05111 595496012030 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 595496012031 metal binding site [ion binding]; metal-binding site 595496012032 putative dimer interface [polypeptide binding]; other site 595496012033 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 595496012034 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 595496012035 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 595496012036 nucleotide binding site [chemical binding]; other site 595496012037 N-acetyl-L-glutamate binding site [chemical binding]; other site 595496012038 argininosuccinate lyase; Provisional; Region: PRK04833 595496012039 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 595496012040 active sites [active] 595496012041 tetramer interface [polypeptide binding]; other site 595496012042 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 595496012043 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496012044 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 595496012045 dimerization interface [polypeptide binding]; other site 595496012046 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 595496012047 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 595496012048 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 595496012049 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 595496012050 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 595496012051 hypothetical protein; Provisional; Region: PRK11056 595496012052 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 595496012053 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 595496012054 S-adenosylmethionine binding site [chemical binding]; other site 595496012055 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 595496012056 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 595496012057 N-terminal plug; other site 595496012058 ligand-binding site [chemical binding]; other site 595496012059 glutamate racemase; Provisional; Region: PRK00865 595496012060 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 595496012061 FAD binding domain; Region: FAD_binding_4; pfam01565 595496012062 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 595496012063 Biotin operon repressor [Transcription]; Region: BirA; COG1654 595496012064 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 595496012065 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 595496012066 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 595496012067 pantothenate kinase; Provisional; Region: PRK05439 595496012068 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 595496012069 ATP-binding site [chemical binding]; other site 595496012070 CoA-binding site [chemical binding]; other site 595496012071 Mg2+-binding site [ion binding]; other site 595496012072 elongation factor Tu; Reviewed; Region: PRK00049 595496012073 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 595496012074 G1 box; other site 595496012075 GEF interaction site [polypeptide binding]; other site 595496012076 GTP/Mg2+ binding site [chemical binding]; other site 595496012077 Switch I region; other site 595496012078 G2 box; other site 595496012079 G3 box; other site 595496012080 Switch II region; other site 595496012081 G4 box; other site 595496012082 G5 box; other site 595496012083 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 595496012084 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 595496012085 Antibiotic Binding Site [chemical binding]; other site 595496012086 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 595496012087 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 595496012088 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 595496012089 putative homodimer interface [polypeptide binding]; other site 595496012090 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 595496012091 heterodimer interface [polypeptide binding]; other site 595496012092 homodimer interface [polypeptide binding]; other site 595496012093 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 595496012094 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 595496012095 23S rRNA interface [nucleotide binding]; other site 595496012096 L7/L12 interface [polypeptide binding]; other site 595496012097 putative thiostrepton binding site; other site 595496012098 L25 interface [polypeptide binding]; other site 595496012099 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 595496012100 mRNA/rRNA interface [nucleotide binding]; other site 595496012101 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 595496012102 23S rRNA interface [nucleotide binding]; other site 595496012103 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 595496012104 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 595496012105 core dimer interface [polypeptide binding]; other site 595496012106 peripheral dimer interface [polypeptide binding]; other site 595496012107 L10 interface [polypeptide binding]; other site 595496012108 L11 interface [polypeptide binding]; other site 595496012109 putative EF-Tu interaction site [polypeptide binding]; other site 595496012110 putative EF-G interaction site [polypeptide binding]; other site 595496012111 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 595496012112 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 595496012113 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 595496012114 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 595496012115 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 595496012116 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 595496012117 RPB3 interaction site [polypeptide binding]; other site 595496012118 RPB1 interaction site [polypeptide binding]; other site 595496012119 RPB11 interaction site [polypeptide binding]; other site 595496012120 RPB10 interaction site [polypeptide binding]; other site 595496012121 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 595496012122 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 595496012123 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 595496012124 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 595496012125 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 595496012126 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 595496012127 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 595496012128 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 595496012129 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 595496012130 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 595496012131 DNA binding site [nucleotide binding] 595496012132 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 595496012133 stationary phase growth adaptation protein; Provisional; Region: PRK09717 595496012134 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 595496012135 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 595496012136 FeS/SAM binding site; other site 595496012137 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 595496012138 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 595496012139 ThiS interaction site; other site 595496012140 putative active site [active] 595496012141 tetramer interface [polypeptide binding]; other site 595496012142 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 595496012143 thiS-thiF/thiG interaction site; other site 595496012144 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 595496012145 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 595496012146 ATP binding site [chemical binding]; other site 595496012147 substrate interface [chemical binding]; other site 595496012148 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 595496012149 thiamine phosphate binding site [chemical binding]; other site 595496012150 active site 595496012151 pyrophosphate binding site [ion binding]; other site 595496012152 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 595496012153 ThiC-associated domain; Region: ThiC-associated; pfam13667 595496012154 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 595496012155 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 595496012156 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 595496012157 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 595496012158 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 595496012159 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 595496012160 putative NADH binding site [chemical binding]; other site 595496012161 putative active site [active] 595496012162 nudix motif; other site 595496012163 putative metal binding site [ion binding]; other site 595496012164 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 595496012165 substrate binding site [chemical binding]; other site 595496012166 active site 595496012167 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 595496012168 Active_site [active] 595496012169 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 595496012170 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 595496012171 IHF dimer interface [polypeptide binding]; other site 595496012172 IHF - DNA interface [nucleotide binding]; other site 595496012173 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 595496012174 zinc resistance protein; Provisional; Region: zraP; PRK11546 595496012175 dimer interface [polypeptide binding]; other site 595496012176 sensor protein ZraS; Provisional; Region: PRK10364 595496012177 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 595496012178 dimer interface [polypeptide binding]; other site 595496012179 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 595496012180 ATP binding site [chemical binding]; other site 595496012181 Mg2+ binding site [ion binding]; other site 595496012182 G-X-G motif; other site 595496012183 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 595496012184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 595496012185 active site 595496012186 phosphorylation site [posttranslational modification] 595496012187 intermolecular recognition site; other site 595496012188 dimerization interface [polypeptide binding]; other site 595496012189 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 595496012190 Walker A motif; other site 595496012191 ATP binding site [chemical binding]; other site 595496012192 Walker B motif; other site 595496012193 arginine finger; other site 595496012194 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 595496012195 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 595496012196 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 595496012197 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 595496012198 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 595496012199 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 595496012200 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 595496012201 purine monophosphate binding site [chemical binding]; other site 595496012202 dimer interface [polypeptide binding]; other site 595496012203 putative catalytic residues [active] 595496012204 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 595496012205 hypothetical protein; Provisional; Region: PRK10039 595496012206 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 595496012207 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 595496012208 Coenzyme A binding pocket [chemical binding]; other site 595496012209 homoserine O-succinyltransferase; Provisional; Region: PRK05368 595496012210 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 595496012211 proposed active site lysine [active] 595496012212 conserved cys residue [active] 595496012213 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 595496012214 malate synthase A; Region: malate_syn_A; TIGR01344 595496012215 active site 595496012216 isocitrate lyase; Provisional; Region: PRK15063 595496012217 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 595496012218 tetramer interface [polypeptide binding]; other site 595496012219 active site 595496012220 Mg2+/Mn2+ binding site [ion binding]; other site 595496012221 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 595496012222 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 595496012223 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 595496012224 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 595496012225 transcriptional repressor IclR; Provisional; Region: PRK11569 595496012226 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 595496012227 Bacterial transcriptional regulator; Region: IclR; pfam01614 595496012228 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 595496012229 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 595496012230 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 595496012231 substrate binding pocket [chemical binding]; other site 595496012232 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 595496012233 B12 binding site [chemical binding]; other site 595496012234 cobalt ligand [ion binding]; other site 595496012235 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 595496012236 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 595496012237 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 595496012238 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 595496012239 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 595496012240 active site pocket [active] 595496012241 oxyanion hole [active] 595496012242 catalytic triad [active] 595496012243 active site nucleophile [active] 595496012244 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 595496012245 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 595496012246 RNA binding surface [nucleotide binding]; other site 595496012247 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 595496012248 probable active site [active] 595496012249 hypothetical protein; Provisional; Region: PRK10515 595496012250 aspartate kinase III; Validated; Region: PRK09084 595496012251 AAK_AKiii-LysC-EC: Amino Acid Kinase Superfamily (AAK), AKiii-LysC-EC: this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKIII. AKIII is a monofunctional class enzyme (LysC) found in some...; Region: AAK_AKiii-LysC-EC; cd04258 595496012252 nucleotide binding site [chemical binding]; other site 595496012253 putative catalytic residues [active] 595496012254 aspartate binding site [chemical binding]; other site 595496012255 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 595496012256 lysine allosteric regulatory site; other site 595496012257 dimer interface [polypeptide binding]; other site 595496012258 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 595496012259 dimer interface [polypeptide binding]; other site 595496012260 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 595496012261 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 595496012262 active site 595496012263 dimer interface [polypeptide binding]; other site 595496012264 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 595496012265 dimer interface [polypeptide binding]; other site 595496012266 active site 595496012267 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 595496012268 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 595496012269 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 595496012270 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 595496012271 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 595496012272 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 595496012273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496012274 putative substrate translocation pore; other site 595496012275 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496012276 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 595496012277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496012278 dimer interface [polypeptide binding]; other site 595496012279 conserved gate region; other site 595496012280 putative PBP binding loops; other site 595496012281 ABC-ATPase subunit interface; other site 595496012282 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 595496012283 potential frameshift: common BLAST hit: gi|110804731|ref|YP_688251.1| putative phage transposase 595496012284 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 595496012285 Mu DNA binding, I gamma subdomain; Region: HTH_Tnp_Mu_2; pfam09039 595496012286 Bacteriophage Mu transposase; Region: DDE_2; pfam02914 595496012287 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 595496012288 Protein of unknown function (DUF1382); Region: DUF1382; pfam07131 595496012289 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 595496012290 phage recombination protein Bet; Region: bet_lambda; TIGR01913 595496012291 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 595496012292 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 595496012293 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 595496012294 Phosphotransferase enzyme family; Region: APH; pfam01636 595496012295 active site 595496012296 ATP binding site [chemical binding]; other site 595496012297 antibiotic binding site [chemical binding]; other site 595496012298 Protein of unknown function (DUF2528); Region: DUF2528; pfam10800 595496012299 Antirestriction protein Ral; Region: Ral; pfam11058 595496012300 36-mer N-terminal peptide of the N protein (N36); Region: N36; pfam11438 595496012301 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 595496012302 non-specific DNA binding site [nucleotide binding]; other site 595496012303 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 595496012304 salt bridge; other site 595496012305 sequence-specific DNA binding site [nucleotide binding]; other site 595496012306 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 595496012307 Catalytic site [active] 595496012308 Cro; Region: Cro; pfam09048 595496012309 Bacteriophage CII protein; Region: Phage_CII; pfam05269 595496012310 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 595496012311 Replication protein P; Region: Phage_lambda_P; pfam06992 595496012312 NinB protein; Region: NinB; pfam05772 595496012313 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 595496012314 Active Sites [active] 595496012315 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 595496012316 Phage NinH protein; Region: Phage_NinH; pfam06322 595496012317 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 595496012318 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 595496012319 active site 595496012320 metal binding site [ion binding]; metal-binding site 595496012321 Antitermination protein; Region: Antiterm; pfam03589 595496012322 Antitermination protein; Region: Antiterm; pfam03589 595496012323 phage holin, lambda family; Region: holin_lambda; TIGR01594 595496012324 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 595496012325 N-acetyl-D-glucosamine binding site [chemical binding]; other site 595496012326 catalytic residue [active] 595496012327 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 595496012328 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 595496012329 Bor protein; Region: Lambda_Bor; pfam06291 595496012330 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 595496012331 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 595496012332 gpW; Region: gpW; pfam02831 595496012333 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 595496012334 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 595496012335 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 595496012336 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 595496012337 tandem repeat interface [polypeptide binding]; other site 595496012338 oligomer interface [polypeptide binding]; other site 595496012339 active site residues [active] 595496012340 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 595496012341 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 595496012342 DNA packaging protein FI; Region: Packaging_FI; pfam14000 595496012343 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 595496012344 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 595496012345 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 595496012346 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 595496012347 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 595496012348 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 595496012349 Minor tail protein T; Region: Phage_tail_T; pfam06223 595496012350 Phage-related minor tail protein [Function unknown]; Region: COG5281 595496012351 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 595496012352 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 595496012353 Phage-related protein [Function unknown]; Region: COG4718 595496012354 Phage-related protein [Function unknown]; Region: gp18; COG4672 595496012355 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 595496012356 MPN+ (JAMM) motif; other site 595496012357 Zinc-binding site [ion binding]; other site 595496012358 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 595496012359 NlpC/P60 family; Region: NLPC_P60; cl17555 595496012360 Phage-related protein, tail component [Function unknown]; Region: COG4723 595496012361 Phage-related protein, tail component [Function unknown]; Region: COG4733 595496012362 Putative phage tail protein; Region: Phage-tail_3; pfam13550 595496012363 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 595496012364 Fibronectin type III protein; Region: DUF3672; pfam12421 595496012365 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 595496012366 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 595496012367 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 595496012368 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496012369 putative substrate translocation pore; other site 595496012370 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 595496012371 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 595496012372 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 595496012373 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 595496012374 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 595496012375 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 595496012376 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 595496012377 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 595496012378 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496012379 catalytic residue [active] 595496012380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 595496012381 dimer interface [polypeptide binding]; other site 595496012382 conserved gate region; other site 595496012383 putative PBP binding loops; other site 595496012384 ABC-ATPase subunit interface; other site 595496012385 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 595496012386 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 595496012387 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 595496012388 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 595496012389 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 595496012390 Walker A/P-loop; other site 595496012391 ATP binding site [chemical binding]; other site 595496012392 Q-loop/lid; other site 595496012393 ABC transporter signature motif; other site 595496012394 Walker B; other site 595496012395 D-loop; other site 595496012396 H-loop/switch region; other site 595496012397 TOBE domain; Region: TOBE_2; pfam08402 595496012398 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 595496012399 trimer interface; other site 595496012400 sugar binding site [chemical binding]; other site 595496012401 maltose regulon periplasmic protein; Provisional; Region: PRK10564 595496012402 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 595496012403 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 595496012404 UbiA prenyltransferase family; Region: UbiA; pfam01040 595496012405 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 595496012406 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 595496012407 putative acyl-acceptor binding pocket; other site 595496012408 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 595496012409 LexA repressor; Validated; Region: PRK00215 595496012410 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 595496012411 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 595496012412 Catalytic site [active] 595496012413 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 595496012414 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 595496012415 hypothetical protein; Provisional; Region: PRK10428 595496012416 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 595496012417 metal binding site 2 [ion binding]; metal-binding site 595496012418 putative DNA binding helix; other site 595496012419 metal binding site 1 [ion binding]; metal-binding site 595496012420 dimer interface [polypeptide binding]; other site 595496012421 structural Zn2+ binding site [ion binding]; other site 595496012422 Protein of unknown function (DUF2713); Region: DUF2713; pfam10897 595496012423 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 595496012424 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 595496012425 FMN binding site [chemical binding]; other site 595496012426 active site 595496012427 catalytic residues [active] 595496012428 substrate binding site [chemical binding]; other site 595496012429 phage shock protein G; Reviewed; Region: pspG; PRK09459 595496012430 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 595496012431 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 595496012432 NADP binding site [chemical binding]; other site 595496012433 dimer interface [polypeptide binding]; other site 595496012434 replicative DNA helicase; Provisional; Region: PRK08006 595496012435 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 595496012436 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 595496012437 Walker A motif; other site 595496012438 ATP binding site [chemical binding]; other site 595496012439 Walker B motif; other site 595496012440 DNA binding loops [nucleotide binding] 595496012441 alanine racemase; Reviewed; Region: alr; PRK00053 595496012442 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 595496012443 active site 595496012444 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 595496012445 substrate binding site [chemical binding]; other site 595496012446 catalytic residues [active] 595496012447 dimer interface [polypeptide binding]; other site 595496012448 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 595496012449 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 595496012450 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496012451 homodimer interface [polypeptide binding]; other site 595496012452 catalytic residue [active] 595496012453 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 595496012454 active site 595496012455 motif I; other site 595496012456 motif II; other site 595496012457 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 595496012458 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 595496012459 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 595496012460 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 595496012461 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 595496012462 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 595496012463 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 595496012464 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 595496012465 dimer interface [polypeptide binding]; other site 595496012466 ssDNA binding site [nucleotide binding]; other site 595496012467 tetramer (dimer of dimers) interface [polypeptide binding]; other site 595496012468 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 595496012469 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 595496012470 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 595496012471 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 595496012472 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 595496012473 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 595496012474 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 595496012475 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 595496012476 DNA binding residues [nucleotide binding] 595496012477 dimer interface [polypeptide binding]; other site 595496012478 [2Fe-2S] cluster binding site [ion binding]; other site 595496012479 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 595496012480 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 595496012481 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 595496012482 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 595496012483 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 595496012484 Na binding site [ion binding]; other site 595496012485 Predicted membrane protein [Function unknown]; Region: COG3162 595496012486 acetyl-CoA synthetase; Provisional; Region: PRK00174 595496012487 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 595496012488 active site 595496012489 CoA binding site [chemical binding]; other site 595496012490 acyl-activating enzyme (AAE) consensus motif; other site 595496012491 AMP binding site [chemical binding]; other site 595496012492 acetate binding site [chemical binding]; other site 595496012493 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 595496012494 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 595496012495 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 595496012496 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 595496012497 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 595496012498 heme lyase subunit NrfE; Provisional; Region: PRK10369 595496012499 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 595496012500 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 595496012501 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 595496012502 binding surface 595496012503 TPR motif; other site 595496012504 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 595496012505 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 595496012506 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 595496012507 Sel1-like repeats; Region: SEL1; smart00671 595496012508 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 595496012509 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 595496012510 [4Fe-4S] binding site [ion binding]; other site 595496012511 molybdopterin cofactor binding site; other site 595496012512 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 595496012513 molybdopterin cofactor binding site; other site 595496012514 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 595496012515 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 595496012516 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 595496012517 multidrug resistance protein MdtN; Provisional; Region: PRK10476 595496012518 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 595496012519 HlyD family secretion protein; Region: HlyD_3; pfam13437 595496012520 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 595496012521 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 595496012522 D-allose kinase; Provisional; Region: PRK09698 595496012523 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 595496012524 nucleotide binding site [chemical binding]; other site 595496012525 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 595496012526 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 595496012527 substrate binding site [chemical binding]; other site 595496012528 hexamer interface [polypeptide binding]; other site 595496012529 metal binding site [ion binding]; metal-binding site 595496012530 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 595496012531 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 595496012532 TM-ABC transporter signature motif; other site 595496012533 D-allose transporter ATP-binding protein; Provisional; Region: PRK09700 595496012534 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 595496012535 Walker A/P-loop; other site 595496012536 ATP binding site [chemical binding]; other site 595496012537 Q-loop/lid; other site 595496012538 ABC transporter signature motif; other site 595496012539 Walker B; other site 595496012540 D-loop; other site 595496012541 H-loop/switch region; other site 595496012542 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 595496012543 D-allose transporter subunit; Provisional; Region: PRK09701 595496012544 Periplasmic allose-binding domain of bacterial transport systems that function as a primary receptor of active transport and chemotaxis; Region: PBP1_allose_binding; cd06320 595496012545 ligand binding site [chemical binding]; other site 595496012546 dimerization interface [polypeptide binding]; other site 595496012547 zinc binding site [ion binding]; other site 595496012548 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 595496012549 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 595496012550 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 595496012551 putative active site [active] 595496012552 ribose 5-phosphate isomerase B; Region: rpiB; TIGR01120 595496012553 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 595496012554 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 595496012555 Coenzyme A binding pocket [chemical binding]; other site 595496012556 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 595496012557 AAA domain; Region: AAA_18; pfam13238 595496012558 active site 595496012559 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 595496012560 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 595496012561 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 595496012562 active site 595496012563 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 595496012564 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 595496012565 Walker A/P-loop; other site 595496012566 ATP binding site [chemical binding]; other site 595496012567 Q-loop/lid; other site 595496012568 ABC transporter signature motif; other site 595496012569 Walker B; other site 595496012570 D-loop; other site 595496012571 H-loop/switch region; other site 595496012572 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 595496012573 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 595496012574 Walker A/P-loop; other site 595496012575 ATP binding site [chemical binding]; other site 595496012576 Q-loop/lid; other site 595496012577 ABC transporter signature motif; other site 595496012578 Walker B; other site 595496012579 D-loop; other site 595496012580 H-loop/switch region; other site 595496012581 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 595496012582 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 595496012583 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 595496012584 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 595496012585 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 595496012586 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 595496012587 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 595496012588 DNA-binding site [nucleotide binding]; DNA binding site 595496012589 UTRA domain; Region: UTRA; pfam07702 595496012590 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 595496012591 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 595496012592 substrate binding pocket [chemical binding]; other site 595496012593 membrane-bound complex binding site; other site 595496012594 hinge residues; other site 595496012595 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 595496012596 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 595496012597 Walker A/P-loop; other site 595496012598 ATP binding site [chemical binding]; other site 595496012599 Q-loop/lid; other site 595496012600 ABC transporter signature motif; other site 595496012601 Walker B; other site 595496012602 D-loop; other site 595496012603 H-loop/switch region; other site 595496012604 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 595496012605 dimer interface [polypeptide binding]; other site 595496012606 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 595496012607 hypothetical protein; Provisional; Region: PRK10220 595496012608 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 595496012609 PhnA protein; Region: PhnA; pfam03831 595496012610 hypothetical protein; Provisional; Region: PRK09866 595496012611 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 595496012612 G1 box; other site 595496012613 GTP/Mg2+ binding site [chemical binding]; other site 595496012614 G2 box; other site 595496012615 Switch I region; other site 595496012616 G3 box; other site 595496012617 Switch II region; other site 595496012618 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 595496012619 G2 box; other site 595496012620 Switch I region; other site 595496012621 G3 box; other site 595496012622 Switch II region; other site 595496012623 G4 box; other site 595496012624 G5 box; other site 595496012625 YjcZ-like protein; Region: YjcZ; pfam13990 595496012626 proline/glycine betaine transporter; Provisional; Region: PRK10642 595496012627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496012628 putative substrate translocation pore; other site 595496012629 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 595496012630 sensor protein BasS/PmrB; Provisional; Region: PRK10755 595496012631 HAMP domain; Region: HAMP; pfam00672 595496012632 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 595496012633 dimer interface [polypeptide binding]; other site 595496012634 phosphorylation site [posttranslational modification] 595496012635 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 595496012636 ATP binding site [chemical binding]; other site 595496012637 Mg2+ binding site [ion binding]; other site 595496012638 G-X-G motif; other site 595496012639 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 595496012640 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 595496012641 active site 595496012642 phosphorylation site [posttranslational modification] 595496012643 intermolecular recognition site; other site 595496012644 dimerization interface [polypeptide binding]; other site 595496012645 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 595496012646 DNA binding site [nucleotide binding] 595496012647 putative metal dependent hydrolase; Provisional; Region: PRK11598 595496012648 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 595496012649 Sulfatase; Region: Sulfatase; pfam00884 595496012650 arginine:agmatin antiporter; Provisional; Region: PRK10644 595496012651 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 595496012652 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 595496012653 arginine decarboxylase; Provisional; Region: PRK15029 595496012654 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 595496012655 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 595496012656 homodimer interface [polypeptide binding]; other site 595496012657 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496012658 catalytic residue [active] 595496012659 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 595496012660 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 595496012661 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 595496012662 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 595496012663 alpha-galactosidase; Provisional; Region: PRK15076 595496012664 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 595496012665 NAD binding site [chemical binding]; other site 595496012666 sugar binding site [chemical binding]; other site 595496012667 divalent metal binding site [ion binding]; other site 595496012668 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 595496012669 dimer interface [polypeptide binding]; other site 595496012670 melibiose:sodium symporter; Provisional; Region: PRK10429 595496012671 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 595496012672 hypothetical protein; Provisional; Region: PRK09867 595496012673 fumarate hydratase; Provisional; Region: PRK15389 595496012674 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 595496012675 Fumarase C-terminus; Region: Fumerase_C; pfam05683 595496012676 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 595496012677 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 595496012678 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 595496012679 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 595496012680 active site 595496012681 phosphorylation site [posttranslational modification] 595496012682 intermolecular recognition site; other site 595496012683 dimerization interface [polypeptide binding]; other site 595496012684 Transcriptional regulator; Region: CitT; pfam12431 595496012685 sensory histidine kinase DcuS; Provisional; Region: PRK11086 595496012686 PAS domain; Region: PAS; smart00091 595496012687 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 595496012688 ATP binding site [chemical binding]; other site 595496012689 Mg2+ binding site [ion binding]; other site 595496012690 G-X-G motif; other site 595496012691 Uncharacterized conserved protein [Function unknown]; Region: COG3592 595496012692 Predicted acetyltransferase [General function prediction only]; Region: COG2388 595496012693 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 595496012694 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 595496012695 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 595496012696 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 595496012697 dimer interface [polypeptide binding]; other site 595496012698 putative anticodon binding site; other site 595496012699 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 595496012700 motif 1; other site 595496012701 active site 595496012702 motif 2; other site 595496012703 motif 3; other site 595496012704 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 595496012705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496012706 putative substrate translocation pore; other site 595496012707 POT family; Region: PTR2; pfam00854 595496012708 lysine decarboxylase CadA; Provisional; Region: PRK15400 595496012709 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 595496012710 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 595496012711 homodimer interface [polypeptide binding]; other site 595496012712 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496012713 catalytic residue [active] 595496012714 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 595496012715 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 595496012716 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 595496012717 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 595496012718 DNA binding site [nucleotide binding] 595496012719 putative transcriptional regulator; Provisional; Region: PRK11640 595496012720 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 595496012721 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 595496012722 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 595496012723 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 595496012724 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 595496012725 DsbD alpha interface [polypeptide binding]; other site 595496012726 catalytic residues [active] 595496012727 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 595496012728 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 595496012729 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 595496012730 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 595496012731 Aspartase; Region: Aspartase; cd01357 595496012732 active sites [active] 595496012733 tetramer interface [polypeptide binding]; other site 595496012734 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 595496012735 putative transporter; Provisional; Region: PRK11021 595496012736 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 595496012737 oligomerisation interface [polypeptide binding]; other site 595496012738 mobile loop; other site 595496012739 roof hairpin; other site 595496012740 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 595496012741 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 595496012742 ring oligomerisation interface [polypeptide binding]; other site 595496012743 ATP/Mg binding site [chemical binding]; other site 595496012744 stacking interactions; other site 595496012745 hinge regions; other site 595496012746 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 595496012747 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 595496012748 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 595496012749 FeS/SAM binding site; other site 595496012750 elongation factor P; Validated; Region: PRK00529 595496012751 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 595496012752 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 595496012753 RNA binding site [nucleotide binding]; other site 595496012754 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 595496012755 RNA binding site [nucleotide binding]; other site 595496012756 entericidin A; Provisional; Region: PRK09810 595496012757 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 595496012758 multidrug efflux system protein; Provisional; Region: PRK11431 595496012759 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 595496012760 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 595496012761 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 595496012762 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 595496012763 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 595496012764 Iron-sulfur protein interface; other site 595496012765 proximal quinone binding site [chemical binding]; other site 595496012766 C-subunit interface; other site 595496012767 distal quinone binding site; other site 595496012768 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 595496012769 D-subunit interface [polypeptide binding]; other site 595496012770 Iron-sulfur protein interface; other site 595496012771 proximal quinone binding site [chemical binding]; other site 595496012772 distal quinone binding site [chemical binding]; other site 595496012773 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 595496012774 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 595496012775 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 595496012776 L-aspartate oxidase; Provisional; Region: PRK06175 595496012777 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 595496012778 poxB regulator PoxA; Provisional; Region: PRK09350 595496012779 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 595496012780 motif 1; other site 595496012781 dimer interface [polypeptide binding]; other site 595496012782 active site 595496012783 motif 2; other site 595496012784 motif 3; other site 595496012785 inner membrane transporter YjeM; Provisional; Region: PRK15238 595496012786 Protein of unknown function (DUF2645); Region: DUF2645; pfam10840 595496012787 putative mechanosensitive channel protein; Provisional; Region: PRK10929 595496012788 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 595496012789 DNA-binding site [nucleotide binding]; DNA binding site 595496012790 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 595496012791 Mechanosensitive ion channel; Region: MS_channel; pfam00924 595496012792 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 595496012793 GTPase RsgA; Reviewed; Region: PRK12288 595496012794 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 595496012795 RNA binding site [nucleotide binding]; other site 595496012796 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 595496012797 GTPase/Zn-binding domain interface [polypeptide binding]; other site 595496012798 GTP/Mg2+ binding site [chemical binding]; other site 595496012799 G4 box; other site 595496012800 G5 box; other site 595496012801 G1 box; other site 595496012802 Switch I region; other site 595496012803 G2 box; other site 595496012804 G3 box; other site 595496012805 Switch II region; other site 595496012806 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 595496012807 catalytic site [active] 595496012808 putative active site [active] 595496012809 putative substrate binding site [chemical binding]; other site 595496012810 dimer interface [polypeptide binding]; other site 595496012811 epoxyqueuosine reductase; Region: TIGR00276 595496012812 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 595496012813 putative carbohydrate kinase; Provisional; Region: PRK10565 595496012814 yjeF N-terminal region; Region: yjeF_nterm; TIGR00197 595496012815 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 595496012816 putative substrate binding site [chemical binding]; other site 595496012817 putative ATP binding site [chemical binding]; other site 595496012818 ADP-binding protein; Provisional; Region: PRK10646 595496012819 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 595496012820 AMIN domain; Region: AMIN; pfam11741 595496012821 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 595496012822 active site 595496012823 metal binding site [ion binding]; metal-binding site 595496012824 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 595496012825 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 595496012826 ATP binding site [chemical binding]; other site 595496012827 Mg2+ binding site [ion binding]; other site 595496012828 G-X-G motif; other site 595496012829 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 595496012830 ATP binding site [chemical binding]; other site 595496012831 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 595496012832 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 595496012833 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 595496012834 bacterial Hfq-like; Region: Hfq; cd01716 595496012835 hexamer interface [polypeptide binding]; other site 595496012836 Sm1 motif; other site 595496012837 RNA binding site [nucleotide binding]; other site 595496012838 Sm2 motif; other site 595496012839 GTPase HflX; Provisional; Region: PRK11058 595496012840 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 595496012841 HflX GTPase family; Region: HflX; cd01878 595496012842 G1 box; other site 595496012843 GTP/Mg2+ binding site [chemical binding]; other site 595496012844 Switch I region; other site 595496012845 G2 box; other site 595496012846 G3 box; other site 595496012847 Switch II region; other site 595496012848 G4 box; other site 595496012849 G5 box; other site 595496012850 FtsH protease regulator HflK; Provisional; Region: PRK10930 595496012851 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 595496012852 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 595496012853 FtsH protease regulator HflC; Provisional; Region: PRK11029 595496012854 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 595496012855 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 595496012856 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 595496012857 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 595496012858 GDP-binding site [chemical binding]; other site 595496012859 ACT binding site; other site 595496012860 IMP binding site; other site 595496012861 Predicted transcriptional regulator [Transcription]; Region: COG1959 595496012862 transcriptional repressor NsrR; Provisional; Region: PRK11014 595496012863 exoribonuclease R; Provisional; Region: PRK11642 595496012864 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 595496012865 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 595496012866 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 595496012867 RNB domain; Region: RNB; pfam00773 595496012868 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 595496012869 RNA binding site [nucleotide binding]; other site 595496012870 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 595496012871 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 595496012872 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 595496012873 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3789 595496012874 PspA/IM30 family; Region: PspA_IM30; pfam04012 595496012875 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 595496012876 Predicted membrane protein [Function unknown]; Region: COG3766 595496012877 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 595496012878 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 595496012879 Predicted integral membrane protein [Function unknown]; Region: COG5463 595496012880 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 595496012881 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 595496012882 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 595496012883 FAD binding site [chemical binding]; other site 595496012884 substrate binding site [chemical binding]; other site 595496012885 catalytic residues [active] 595496012886 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 595496012887 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 595496012888 esterase; Provisional; Region: PRK10566 595496012889 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 595496012890 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 595496012891 transcriptional repressor UlaR; Provisional; Region: PRK13509 595496012892 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 595496012893 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 595496012894 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 595496012895 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 595496012896 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 595496012897 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 595496012898 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 595496012899 active site 595496012900 P-loop; other site 595496012901 phosphorylation site [posttranslational modification] 595496012902 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 595496012903 active site 595496012904 phosphorylation site [posttranslational modification] 595496012905 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 595496012906 active site 595496012907 dimer interface [polypeptide binding]; other site 595496012908 magnesium binding site [ion binding]; other site 595496012909 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 595496012910 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 595496012911 AP (apurinic/apyrimidinic) site pocket; other site 595496012912 DNA interaction; other site 595496012913 Metal-binding active site; metal-binding site 595496012914 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 595496012915 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 595496012916 intersubunit interface [polypeptide binding]; other site 595496012917 active site 595496012918 Zn2+ binding site [ion binding]; other site 595496012919 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 595496012920 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 595496012921 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 595496012922 dimer interface [polypeptide binding]; other site 595496012923 ssDNA binding site [nucleotide binding]; other site 595496012924 tetramer (dimer of dimers) interface [polypeptide binding]; other site 595496012925 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 595496012926 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 595496012927 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 595496012928 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 595496012929 Protein of unknown function (DUF2686); Region: DUF2686; pfam10887 595496012930 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 595496012931 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 595496012932 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 595496012933 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 595496012934 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 595496012935 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 595496012936 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 595496012937 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 595496012938 Hemerythrin-like domain; Region: Hr-like; cd12108 595496012939 Fe binding site [ion binding]; other site 595496012940 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 595496012941 EamA-like transporter family; Region: EamA; pfam00892 595496012942 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 595496012943 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 595496012944 NADP binding site [chemical binding]; other site 595496012945 Predicted transcriptional regulators [Transcription]; Region: COG1733 595496012946 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 595496012947 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 595496012948 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 595496012949 active site 595496012950 metal binding site [ion binding]; metal-binding site 595496012951 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 595496012952 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 595496012953 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 595496012954 active site 595496012955 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 595496012956 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 595496012957 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 595496012958 Domain of unknown function DUF21; Region: DUF21; pfam01595 595496012959 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 595496012960 Transporter associated domain; Region: CorC_HlyC; smart01091 595496012961 methionine sulfoxide reductase A; Provisional; Region: PRK00058 595496012962 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 595496012963 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 595496012964 Surface antigen; Region: Bac_surface_Ag; pfam01103 595496012965 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 595496012966 Family of unknown function (DUF490); Region: DUF490; pfam04357 595496012967 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 595496012968 putative active site pocket [active] 595496012969 dimerization interface [polypeptide binding]; other site 595496012970 putative catalytic residue [active] 595496012971 antitoxin ChpS; Provisional; Region: PRK11347 595496012972 toxin ChpB; Provisional; Region: PRK09812 595496012973 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 595496012974 dimer interface [polypeptide binding]; other site 595496012975 substrate binding site [chemical binding]; other site 595496012976 metal binding sites [ion binding]; metal-binding site 595496012977 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 595496012978 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 595496012979 putative ligand binding site [chemical binding]; other site 595496012980 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 595496012981 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 595496012982 Walker A/P-loop; other site 595496012983 ATP binding site [chemical binding]; other site 595496012984 Q-loop/lid; other site 595496012985 ABC transporter signature motif; other site 595496012986 Walker B; other site 595496012987 D-loop; other site 595496012988 H-loop/switch region; other site 595496012989 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 595496012990 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 595496012991 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 595496012992 TM-ABC transporter signature motif; other site 595496012993 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 595496012994 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 595496012995 TM-ABC transporter signature motif; other site 595496012996 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 595496012997 AMP binding site [chemical binding]; other site 595496012998 metal binding site [ion binding]; metal-binding site 595496012999 active site 595496013000 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 595496013001 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 595496013002 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 595496013003 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 595496013004 hypothetical protein; Provisional; Region: PRK05255 595496013005 peptidase PmbA; Provisional; Region: PRK11040 595496013006 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 595496013007 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 595496013008 FeS/SAM binding site; other site 595496013009 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 595496013010 ATP cone domain; Region: ATP-cone; pfam03477 595496013011 Class III ribonucleotide reductase; Region: RNR_III; cd01675 595496013012 effector binding site; other site 595496013013 active site 595496013014 Zn binding site [ion binding]; other site 595496013015 glycine loop; other site 595496013016 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 595496013017 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 595496013018 Ca binding site [ion binding]; other site 595496013019 active site 595496013020 catalytic site [active] 595496013021 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 595496013022 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 595496013023 active site turn [active] 595496013024 phosphorylation site [posttranslational modification] 595496013025 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 595496013026 trehalose repressor; Provisional; Region: treR; PRK09492 595496013027 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 595496013028 DNA binding site [nucleotide binding] 595496013029 domain linker motif; other site 595496013030 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 595496013031 dimerization interface [polypeptide binding]; other site 595496013032 ligand binding site [chemical binding]; other site 595496013033 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 595496013034 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 595496013035 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 595496013036 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 595496013037 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 595496013038 motif II; other site 595496013039 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 595496013040 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 595496013041 homotrimer interaction site [polypeptide binding]; other site 595496013042 putative active site [active] 595496013043 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 595496013044 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 595496013045 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 595496013046 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 595496013047 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 595496013048 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 595496013049 PyrBI operon leader peptide; Region: PyrBI_leader; pfam08052 595496013050 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 595496013051 homotrimer interaction site [polypeptide binding]; other site 595496013052 putative active site [active] 595496013053 oxidoreductase; Provisional; Region: PRK12742 595496013054 classical (c) SDRs; Region: SDR_c; cd05233 595496013055 NAD(P) binding site [chemical binding]; other site 595496013056 active site 595496013057 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 595496013058 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 595496013059 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 595496013060 SopA-like central domain; Region: SopA; pfam13981 595496013061 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 595496013062 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 595496013063 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 595496013064 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 595496013065 RNase E inhibitor protein; Provisional; Region: PRK11191 595496013066 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 595496013067 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 595496013068 Coenzyme A binding pocket [chemical binding]; other site 595496013069 Predicted membrane protein [Function unknown]; Region: COG4269 595496013070 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 595496013071 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 595496013072 HIGH motif; other site 595496013073 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 595496013074 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 595496013075 active site 595496013076 KMSKS motif; other site 595496013077 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 595496013078 tRNA binding surface [nucleotide binding]; other site 595496013079 anticodon binding site; other site 595496013080 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 595496013081 DNA polymerase III subunit chi; Validated; Region: PRK05728 595496013082 multifunctional aminopeptidase A; Provisional; Region: PRK00913 595496013083 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 595496013084 interface (dimer of trimers) [polypeptide binding]; other site 595496013085 Substrate-binding/catalytic site; other site 595496013086 Zn-binding sites [ion binding]; other site 595496013087 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 595496013088 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 595496013089 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 595496013090 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 595496013091 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 595496013092 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 595496013093 Walker A motif; other site 595496013094 ATP binding site [chemical binding]; other site 595496013095 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 595496013096 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 595496013097 DNA binding site [nucleotide binding] 595496013098 domain linker motif; other site 595496013099 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 595496013100 putative dimerization interface [polypeptide binding]; other site 595496013101 putative ligand binding site [chemical binding]; other site 595496013102 fructuronate transporter; Provisional; Region: PRK10034; cl15264 595496013103 gluconate transporter; Region: gntP; TIGR00791 595496013104 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 595496013105 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 595496013106 NADP binding site [chemical binding]; other site 595496013107 homodimer interface [polypeptide binding]; other site 595496013108 active site 595496013109 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 595496013110 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 595496013111 putative NAD(P) binding site [chemical binding]; other site 595496013112 catalytic Zn binding site [ion binding]; other site 595496013113 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 595496013114 ATP-binding site [chemical binding]; other site 595496013115 Gluconate-6-phosphate binding site [chemical binding]; other site 595496013116 Shikimate kinase; Region: SKI; pfam01202 595496013117 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 595496013118 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 595496013119 putative NAD(P) binding site [chemical binding]; other site 595496013120 putative substrate binding site [chemical binding]; other site 595496013121 catalytic Zn binding site [ion binding]; other site 595496013122 structural Zn binding site [ion binding]; other site 595496013123 dimer interface [polypeptide binding]; other site 595496013124 IS2 repressor TnpA; Reviewed; Region: PRK09413 595496013125 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 595496013126 IS2 transposase TnpB; Reviewed; Region: PRK09409 595496013127 HTH-like domain; Region: HTH_21; pfam13276 595496013128 Integrase core domain; Region: rve; pfam00665 595496013129 Integrase core domain; Region: rve_3; pfam13683 595496013130 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 595496013131 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 595496013132 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 595496013133 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 595496013134 putative sialic acid transporter; Provisional; Region: PRK12307 595496013135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496013136 putative substrate translocation pore; other site 595496013137 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 595496013138 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 595496013139 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 595496013140 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 595496013141 Helix-turn-helix domain; Region: HTH_38; pfam13936 595496013142 Integrase core domain; Region: rve; pfam00665 595496013143 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 595496013144 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 595496013145 Walker A/P-loop; other site 595496013146 ATP binding site [chemical binding]; other site 595496013147 Q-loop/lid; other site 595496013148 ABC transporter signature motif; other site 595496013149 Walker B; other site 595496013150 D-loop; other site 595496013151 H-loop/switch region; other site 595496013152 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 595496013153 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 595496013154 ABC-ATPase subunit interface; other site 595496013155 dimer interface [polypeptide binding]; other site 595496013156 putative PBP binding regions; other site 595496013157 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 595496013158 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 595496013159 dimer interface [polypeptide binding]; other site 595496013160 ABC-ATPase subunit interface; other site 595496013161 putative PBP binding regions; other site 595496013162 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 595496013163 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 595496013164 siderophore binding site; other site 595496013165 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 595496013166 Secretin and TonB N terminus short domain; Region: STN; smart00965 595496013167 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 595496013168 N-terminal plug; other site 595496013169 ligand-binding site [chemical binding]; other site 595496013170 fec operon regulator FecR; Reviewed; Region: PRK09774 595496013171 FecR protein; Region: FecR; pfam04773 595496013172 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 595496013173 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 595496013174 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 595496013175 DNA binding residues [nucleotide binding] 595496013176 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 595496013177 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 595496013178 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 595496013179 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 595496013180 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 595496013181 DNA binding residues [nucleotide binding] 595496013182 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 595496013183 gluconate transporter; Region: gntP; TIGR00791 595496013184 fructuronate transporter; Provisional; Region: PRK10034; cl15264 595496013185 putative dehydratase; Provisional; Region: PRK08211 595496013186 Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism / Carbohydrate transport and metabolism]; Region: IlvD; COG0129 595496013187 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 595496013188 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 595496013189 inhibitor site; inhibition site 595496013190 active site 595496013191 dimer interface [polypeptide binding]; other site 595496013192 catalytic residue [active] 595496013193 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 595496013194 Transcriptional regulator [Transcription]; Region: IclR; COG1414 595496013195 Bacterial transcriptional regulator; Region: IclR; pfam01614 595496013196 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 595496013197 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 595496013198 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 595496013199 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 595496013200 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 595496013201 substrate binding site [chemical binding]; other site 595496013202 hexamer interface [polypeptide binding]; other site 595496013203 metal binding site [ion binding]; metal-binding site 595496013204 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 595496013205 active site 595496013206 phosphorylation site [posttranslational modification] 595496013207 membrane complex biogenesis protein, BtpA family; Region: thylakoid_BtpA; TIGR00259 595496013208 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 595496013209 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 595496013210 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 595496013211 active site 595496013212 P-loop; other site 595496013213 phosphorylation site [posttranslational modification] 595496013214 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 595496013215 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 595496013216 oligomer interface [polypeptide binding]; other site 595496013217 active site 595496013218 metal binding site [ion binding]; metal-binding site 595496013219 Methyltransferase domain; Region: Methyltransf_31; pfam13847 595496013220 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 595496013221 S-adenosylmethionine binding site [chemical binding]; other site 595496013222 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 595496013223 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 595496013224 Coenzyme A binding pocket [chemical binding]; other site 595496013225 hypothetical protein; Provisional; Region: PRK13687 595496013226 Domain of unknown function (DUF303); Region: DUF303; pfam03629 595496013227 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 595496013228 Kelch motif; Region: Kelch_1; pfam01344 595496013229 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 595496013230 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 595496013231 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 595496013232 Int/Topo IB signature motif; other site 595496013233 Fimbrial protein; Region: Fimbrial; cl01416 595496013234 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 595496013235 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 595496013236 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 595496013237 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 595496013238 outer membrane usher protein; Provisional; Region: PRK15193 595496013239 PapC N-terminal domain; Region: PapC_N; pfam13954 595496013240 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 595496013241 PapC C-terminal domain; Region: PapC_C; pfam13953 595496013242 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 595496013243 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 595496013244 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 595496013245 mannosyl binding site [chemical binding]; other site 595496013246 Fimbrial protein; Region: Fimbrial; pfam00419 595496013247 fructuronate transporter; Provisional; Region: PRK10034 595496013248 gluconate transporter; Region: gntP; TIGR00791 595496013249 mannonate dehydratase; Region: uxuA; TIGR00695 595496013250 mannonate dehydratase; Provisional; Region: PRK03906 595496013251 D-mannonate oxidoreductase; Provisional; Region: PRK15037 595496013252 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 595496013253 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 595496013254 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 595496013255 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 595496013256 DNA-binding site [nucleotide binding]; DNA binding site 595496013257 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 595496013258 Protein of unknown function (DUF2686); Region: DUF2686; pfam10887 595496013259 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 595496013260 cell density-dependent motility repressor; Provisional; Region: PRK10082 595496013261 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 595496013262 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 595496013263 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 595496013264 isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975 595496013265 dimer interface [polypeptide binding]; other site 595496013266 active site 595496013267 hypothetical protein; Provisional; Region: PRK10519 595496013268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 595496013269 Nucleoside recognition; Region: Gate; pfam07670 595496013270 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 595496013271 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 595496013272 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 595496013273 SdiA-regulated; Region: SdiA-regulated; pfam06977 595496013274 SdiA-regulated; Region: SdiA-regulated; cd09971 595496013275 putative active site [active] 595496013276 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 595496013277 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 595496013278 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 595496013279 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 595496013280 Predicted membrane protein [Function unknown]; Region: COG2733 595496013281 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 595496013282 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496013283 putative substrate translocation pore; other site 595496013284 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 595496013285 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 595496013286 DNA-binding site [nucleotide binding]; DNA binding site 595496013287 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 595496013288 pyridoxal 5'-phosphate binding site [chemical binding]; other site 595496013289 homodimer interface [polypeptide binding]; other site 595496013290 catalytic residue [active] 595496013291 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 595496013292 5-methylcytosine-specific restriction enzyme subunit McrC; Provisional; Region: PRK09736 595496013293 5-methylcytosine-specific restriction enzyme subunit McrB; Provisional; Region: PRK11331 595496013294 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 595496013295 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 595496013296 Walker A motif; other site 595496013297 ATP binding site [chemical binding]; other site 595496013298 Walker B motif; other site 595496013299 arginine finger; other site 595496013300 endoribonuclease SymE; Provisional; Region: PRK13605 595496013301 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 595496013302 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 595496013303 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 595496013304 HsdM N-terminal domain; Region: HsdM_N; pfam12161 595496013305 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 595496013306 Methyltransferase domain; Region: Methyltransf_26; pfam13659 595496013307 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 595496013308 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 595496013309 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 595496013310 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 595496013311 ATP binding site [chemical binding]; other site 595496013312 putative Mg++ binding site [ion binding]; other site 595496013313 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 595496013314 Mrr N-terminal domain; Region: Mrr_N; pfam14338 595496013315 Restriction endonuclease; Region: Mrr_cat; pfam04471 595496013316 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 595496013317 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 595496013318 P-loop, Walker A motif; other site 595496013319 Base recognition motif; other site 595496013320 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 595496013321 Uncharacterized small protein [Function unknown]; Region: COG2879 595496013322 carbon starvation protein A; Provisional; Region: PRK15015 595496013323 Carbon starvation protein CstA; Region: CstA; pfam02554 595496013324 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 595496013325 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 595496013326 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 595496013327 dimer interface [polypeptide binding]; other site 595496013328 ligand binding site [chemical binding]; other site 595496013329 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 595496013330 dimerization interface [polypeptide binding]; other site 595496013331 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 595496013332 dimer interface [polypeptide binding]; other site 595496013333 putative CheW interface [polypeptide binding]; other site 595496013334 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 595496013335 D-galactonate transporter; Region: 2A0114; TIGR00893 595496013336 putative substrate translocation pore; other site 595496013337 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 595496013338 DNA-binding site [nucleotide binding]; DNA binding site 595496013339 Transcriptional regulators [Transcription]; Region: GntR; COG1802 595496013340 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 595496013341 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 595496013342 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 595496013343 putative NAD(P) binding site [chemical binding]; other site 595496013344 catalytic Zn binding site [ion binding]; other site 595496013345 structural Zn binding site [ion binding]; other site 595496013346 phosphoglycerol transferase I; Provisional; Region: PRK03776 595496013347 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 595496013348 hypothetical protein; Provisional; Region: PRK11667 595496013349 DNA replication protein DnaC; Validated; Region: PRK07952 595496013350 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 595496013351 Walker A motif; other site 595496013352 ATP binding site [chemical binding]; other site 595496013353 Walker B motif; other site 595496013354 primosomal protein DnaI; Provisional; Region: PRK02854 595496013355 hypothetical protein; Provisional; Region: PRK09917 595496013356 Uncharacterized conserved protein [Function unknown]; Region: COG2966 595496013357 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 595496013358 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 595496013359 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 595496013360 DNA binding residues [nucleotide binding] 595496013361 dimerization interface [polypeptide binding]; other site 595496013362 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 595496013363 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 595496013364 DNA binding residues [nucleotide binding] 595496013365 dimerization interface [polypeptide binding]; other site 595496013366 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 595496013367 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 595496013368 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 595496013369 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 595496013370 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 595496013371 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 595496013372 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 595496013373 S-adenosylmethionine binding site [chemical binding]; other site 595496013374 DNA polymerase III subunit psi; Validated; Region: PRK06856 595496013375 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 595496013376 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 595496013377 Coenzyme A binding pocket [chemical binding]; other site 595496013378 dUMP phosphatase; Provisional; Region: PRK09449 595496013379 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 595496013380 motif II; other site 595496013381 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 595496013382 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 595496013383 G1 box; other site 595496013384 putative GEF interaction site [polypeptide binding]; other site 595496013385 GTP/Mg2+ binding site [chemical binding]; other site 595496013386 Switch I region; other site 595496013387 G2 box; other site 595496013388 G3 box; other site 595496013389 Switch II region; other site 595496013390 G4 box; other site 595496013391 G5 box; other site 595496013392 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 595496013393 periplasmic protein; Provisional; Region: PRK10568 595496013394 BON domain; Region: BON; pfam04972 595496013395 BON domain; Region: BON; pfam04972 595496013396 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 595496013397 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 595496013398 active site 595496013399 nucleophile elbow; other site 595496013400 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 595496013401 active site 595496013402 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 595496013403 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 595496013404 FeS/SAM binding site; other site 595496013405 hypothetical protein; Provisional; Region: PRK10977 595496013406 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 595496013407 intersubunit interface [polypeptide binding]; other site 595496013408 active site 595496013409 catalytic residue [active] 595496013410 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 595496013411 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 595496013412 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 595496013413 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 595496013414 phosphopentomutase; Provisional; Region: PRK05362 595496013415 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 595496013416 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 595496013417 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 595496013418 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 595496013419 HipA-like N-terminal domain; Region: HipA_N; pfam07805 595496013420 HipA-like C-terminal domain; Region: HipA_C; pfam07804 595496013421 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 595496013422 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 595496013423 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 595496013424 hypothetical protein; Provisional; Region: PRK11246 595496013425 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 595496013426 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 595496013427 motif II; other site 595496013428 DNA repair protein RadA; Region: sms; TIGR00416 595496013429 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 595496013430 Walker A motif/ATP binding site; other site 595496013431 ATP binding site [chemical binding]; other site 595496013432 Walker B motif; other site 595496013433 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 595496013434 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 595496013435 non-specific DNA binding site [nucleotide binding]; other site 595496013436 salt bridge; other site 595496013437 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 595496013438 sequence-specific DNA binding site [nucleotide binding]; other site 595496013439 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 595496013440 active site 595496013441 (T/H)XGH motif; other site 595496013442 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 595496013443 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 595496013444 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 595496013445 Walker A/P-loop; other site 595496013446 ATP binding site [chemical binding]; other site 595496013447 Q-loop/lid; other site 595496013448 ABC transporter signature motif; other site 595496013449 Walker B; other site 595496013450 D-loop; other site 595496013451 H-loop/switch region; other site 595496013452 ABC transporter; Region: ABC_tran_2; pfam12848 595496013453 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 595496013454 lytic murein transglycosylase; Provisional; Region: PRK11619 595496013455 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 595496013456 N-acetyl-D-glucosamine binding site [chemical binding]; other site 595496013457 catalytic residue [active] 595496013458 Trp operon repressor; Provisional; Region: PRK01381 595496013459 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 595496013460 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 595496013461 catalytic core [active] 595496013462 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 595496013463 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 595496013464 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 595496013465 hypothetical protein; Provisional; Region: PRK10756 595496013466 CreA protein; Region: CreA; pfam05981 595496013467 DNA-binding response regulator CreB; Provisional; Region: PRK11083 595496013468 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 595496013469 active site 595496013470 phosphorylation site [posttranslational modification] 595496013471 intermolecular recognition site; other site 595496013472 dimerization interface [polypeptide binding]; other site 595496013473 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 595496013474 DNA binding site [nucleotide binding] 595496013475 sensory histidine kinase CreC; Provisional; Region: PRK11100 595496013476 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 595496013477 dimerization interface [polypeptide binding]; other site 595496013478 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 595496013479 dimer interface [polypeptide binding]; other site 595496013480 phosphorylation site [posttranslational modification] 595496013481 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 595496013482 ATP binding site [chemical binding]; other site 595496013483 Mg2+ binding site [ion binding]; other site 595496013484 G-X-G motif; other site 595496013485 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 595496013486 two-component response regulator; Provisional; Region: PRK11173 595496013487 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 595496013488 active site 595496013489 phosphorylation site [posttranslational modification] 595496013490 intermolecular recognition site; other site 595496013491 dimerization interface [polypeptide binding]; other site 595496013492 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 595496013493 DNA binding site [nucleotide binding] 595496013494 putative RNA methyltransferase; Provisional; Region: PRK10433 595496013495 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050