-- dump date 20140619_081423 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type YP_003043230.1 254160124 8178299 190..255 1 NC_012967.1 similar to b0001; thr operon leader peptide 255 thrL 8178299 thrL Escherichia coli B str. REL606 thr operon leader peptide YP_003043230.1 190 D 413997 CDS YP_003043231.1 254160125 8178300 336..2798 1 NC_012967.1 multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartokinase I/homoserine dehydrogenase I 2798 thrA 8178300 thrA Escherichia coli B str. REL606 bifunctional aspartokinase I/homoserine dehydrogenase I YP_003043231.1 336 D 413997 CDS YP_003043232.1 254160126 8175009 2800..3732 1 NC_012967.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 3732 thrB 8175009 thrB Escherichia coli B str. REL606 homoserine kinase YP_003043232.1 2800 D 413997 CDS YP_003043233.1 254160127 8175010 3733..5019 1 NC_012967.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 5019 thrC 8175010 thrC Escherichia coli B str. REL606 threonine synthase YP_003043233.1 3733 D 413997 CDS YP_003043234.1 254160128 8175011 5232..5528 1 NC_012967.1 similar to b0005; hypothetical protein 5528 yaaX 8175011 yaaX Escherichia coli B str. REL606 hypothetical protein YP_003043234.1 5232 D 413997 CDS YP_003043235.1 254160129 8178301 complement(5681..6457) 1 NC_012967.1 similar to b0006; hypothetical protein 6457 yaaA 8178301 yaaA Escherichia coli B str. REL606 hypothetical protein YP_003043235.1 5681 R 413997 CDS YP_003043236.1 254160130 8175012 complement(6527..7957) 1 NC_012967.1 similar to b0007; putative transporter 7957 yaaJ 8175012 yaaJ Escherichia coli B str. REL606 putative transporter YP_003043236.1 6527 R 413997 CDS YP_003043237.1 254160131 8175013 8236..9189 1 NC_012967.1 similar to b0008; transaldolase B 9189 talB 8175013 talB Escherichia coli B str. REL606 transaldolase B YP_003043237.1 8236 D 413997 CDS YP_003043238.1 254160132 8175014 9304..9891 1 NC_012967.1 forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MogA 9891 mogA 8175014 mogA Escherichia coli B str. REL606 molybdenum cofactor biosynthesis protein MogA YP_003043238.1 9304 D 413997 CDS YP_003043239.1 254160133 8175015 complement(9926..10492) 1 NC_012967.1 similar to b0010; hypothetical protein 10492 yaaH 8175015 yaaH Escherichia coli B str. REL606 hypothetical protein YP_003043239.1 9926 R 413997 CDS YP_003043242.1 254160134 8175016 complement(11380..11784) 1 NC_012967.1 similar to b0013; hypothetical protein 11784 yaaI 8175016 yaaI Escherichia coli B str. REL606 hypothetical protein YP_003043242.1 11380 R 413997 CDS YP_003043243.1 254160135 8178302 12161..14077 1 NC_012967.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 14077 dnaK 8178302 dnaK Escherichia coli B str. REL606 molecular chaperone DnaK YP_003043243.1 12161 D 413997 CDS YP_003043244.1 254160136 8175017 14166..15296 1 NC_012967.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 15296 dnaJ 8175017 dnaJ Escherichia coli B str. REL606 chaperone protein DnaJ YP_003043244.1 14166 D 413997 CDS YP_003043245.1 254160137 8175018 15443..16555 1 NC_012967.1 IS186/IS421 transposase 16555 insL-1 8175018 insL-1 Escherichia coli B str. REL606 IS186/IS421 transposase YP_003043245.1 15443 D 413997 CDS YP_003043246.1 254160139 8175019 complement(16749..16958) 1 NC_012967.1 similar to b0018; regulatory protein for HokC, overlaps CDS of hokC 16958 mokC 8175019 mokC Escherichia coli B str. REL606 regulatory protein for HokC, overlaps CDS of hokC YP_003043246.1 16749 R 413997 CDS YP_003043247.1 254160138 8175021 complement(16749..16901) 1 NC_012967.1 similar to b4412; small toxic membrane polypeptide 16901 hokC 8175021 hokC Escherichia coli B str. REL606 small toxic membrane polypeptide YP_003043247.1 16749 R 413997 CDS YP_003043248.1 254160140 8175020 17488..18654 1 NC_012967.1 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH; pH-dependent sodium/proton antiporter 18654 nhaA 8175020 nhaA Escherichia coli B str. REL606 pH-dependent sodium/proton antiporter YP_003043248.1 17488 D 413997 CDS YP_003043249.1 254160141 8175022 18714..19619 1 NC_012967.1 Na+/H+ antiporter regulatory protein; activates the genes nhaA and osmC; transcriptional activator NhaR 19619 nhaR 8175022 nhaR Escherichia coli B str. REL606 transcriptional activator NhaR YP_003043249.1 18714 D 413997 CDS YP_003043250.1 254160142 8175023 complement(19658..20617) 1 NC_012967.1 hypothetical protein 20617 8175023 ECB_00020 Escherichia coli B str. REL606 hypothetical protein YP_003043250.1 19658 R 413997 CDS YP_003043251.1 254160143 8175024 complement(20630..21775) 1 NC_012967.1 putative usher protein 21775 8175024 ECB_00021 Escherichia coli B str. REL606 putative usher protein YP_003043251.1 20630 R 413997 CDS YP_003043252.1 254160144 8178303 complement(22208..22912) 1 NC_012967.1 hypothetical protein 22912 8178303 ECB_00022 Escherichia coli B str. REL606 hypothetical protein YP_003043252.1 22208 R 413997 CDS YP_003043253.1 254160145 8175025 23346..23621 1 NC_012967.1 IS1 protein InsA 23621 insA-1 8175025 insA-1 Escherichia coli B str. REL606 IS1 protein InsA YP_003043253.1 23346 D 413997 CDS YP_003043254.1 254160146 8175026 23540..24043 1 NC_012967.1 IS1 protein InsB 24043 insB-1 8175026 insB-1 Escherichia coli B str. REL606 IS1 protein InsB YP_003043254.1 23540 D 413997 CDS YP_003043255.1 254160147 8178861 complement(24054..24404) 1 NC_012967.1 hypothetical protein 24404 8178861 ECB_00025 Escherichia coli B str. REL606 hypothetical protein YP_003043255.1 24054 R 413997 CDS YP_003043256.1 254160148 8175027 complement(24701..24865) 1 NC_012967.1 hypothetical protein 24865 8175027 ECB_00026 Escherichia coli B str. REL606 hypothetical protein YP_003043256.1 24701 R 413997 CDS YP_003043257.1 254160149 8175028 complement(24887..25150) 1 NC_012967.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 25150 rpsT 8175028 rpsT Escherichia coli B str. REL606 30S ribosomal protein S20 YP_003043257.1 24887 R 413997 CDS YP_003043258.1 254160150 8178862 25253..25471 1 NC_012967.1 similar to b0024; hypothetical protein 25471 yaaY 8178862 yaaY Escherichia coli B str. REL606 hypothetical protein YP_003043258.1 25253 D 413997 CDS YP_003043259.1 254160151 8175029 25479..26420 1 NC_012967.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 26420 ribF 8175029 ribF Escherichia coli B str. REL606 bifunctional riboflavin kinase/FMN adenylyltransferase YP_003043259.1 25479 D 413997 CDS YP_003043260.1 254160152 8178863 26463..29279 1 NC_012967.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 29279 ileS 8178863 ileS Escherichia coli B str. REL606 isoleucyl-tRNA synthetase YP_003043260.1 26463 D 413997 CDS YP_003043261.1 254160153 8175030 29279..29773 1 NC_012967.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 29773 lspA 8175030 lspA Escherichia coli B str. REL606 lipoprotein signal peptidase YP_003043261.1 29279 D 413997 CDS YP_003043262.1 254160154 8175031 29898..30347 1 NC_012967.1 similar to b0028; FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase) 30347 fkpB 8175031 fkpB Escherichia coli B str. REL606 FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase) YP_003043262.1 29898 D 413997 CDS YP_003043263.1 254160155 8175032 30349..31299 1 NC_012967.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 31299 ispH 8175032 ispH Escherichia coli B str. REL606 4-hydroxy-3-methylbut-2-enyl diphosphate reductase YP_003043263.1 30349 D 413997 CDS YP_003043264.1 254160156 8178864 31365..32279 1 NC_012967.1 catalyzes the hydrolysis of both purine and pyrimidine ribonucleosides; ribonucleoside hydrolase RihC 32279 rihC 8178864 rihC Escherichia coli B str. REL606 ribonucleoside hydrolase RihC YP_003043264.1 31365 D 413997 CDS YP_003043265.1 254160157 8175033 32446..33267 1 NC_012967.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 33267 dapB 8175033 dapB Escherichia coli B str. REL606 dihydrodipicolinate reductase YP_003043265.1 32446 D 413997 CDS YP_003043266.1 254160158 8175034 33722..34870 1 NC_012967.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 34870 carA 8175034 carA Escherichia coli B str. REL606 carbamoyl phosphate synthase small subunit YP_003043266.1 33722 D 413997 CDS YP_003043267.1 254160159 8175035 34888..38109 1 NC_012967.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 38109 carB 8175035 carB Escherichia coli B str. REL606 carbamoyl phosphate synthase large subunit YP_003043267.1 34888 D 413997 CDS YP_003043268.1 254160160 8175036 38371..38766 1 NC_012967.1 regulator of carnitine metabolism; induces the caiTABCDE and fixABCX operons; DNA-binding transcriptional activator CaiF 38766 caiF 8175036 caiF Escherichia coli B str. REL606 DNA-binding transcriptional activator CaiF YP_003043268.1 38371 D 413997 CDS YP_003043269.1 254160161 8175037 complement(38975..39565) 1 NC_012967.1 involved in the synthesis of a cofactor required for carnitine dehydratase and carnitine racemase activities; carnitine operon protein CaiE 39565 caiE 8175037 caiE Escherichia coli B str. REL606 carnitine operon protein CaiE YP_003043269.1 38975 R 413997 CDS YP_003043270.1 254160162 8175038 complement(39571..40464) 1 NC_012967.1 catalyzes the dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA; carnitinyl-CoA dehydratase 40464 caiD 8175038 caiD Escherichia coli B str. REL606 carnitinyl-CoA dehydratase YP_003043270.1 39571 R 413997 CDS YP_003043271.1 254160163 8175039 complement(40465..42033) 1 NC_012967.1 similar to b0037; putative crotonobetaine/carnitine-CoA ligase 42033 caiC 8175039 caiC Escherichia coli B str. REL606 putative crotonobetaine/carnitine-CoA ligase YP_003043271.1 40465 R 413997 CDS YP_003043272.1 254160164 8178304 complement(43437..44579) 1 NC_012967.1 catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA; crotonobetainyl-CoA dehydrogenase 44579 caiA 8178304 caiA Escherichia coli B str. REL606 crotonobetainyl-CoA dehydrogenase YP_003043272.1 43437 R 413997 CDS YP_003043273.1 254160165 8175041 complement(44610..46124) 1 NC_012967.1 catalyzes the exchange of L-carnitine for gamma-butyrobetaine in carnitine metabolism; L-carnitine/gamma-butyrobetaine antiporter 46124 caiT 8175041 caiT Escherichia coli B str. REL606 L-carnitine/gamma-butyrobetaine antiporter YP_003043273.1 44610 R 413997 CDS YP_003043274.1 254160166 8178865 46598..47368 1 NC_012967.1 required for anaerobic carnitine reduction, may act to transfer electrons to crotonobetaine reductase; putative electron transfer flavoprotein FixA 47368 fixA 8178865 fixA Escherichia coli B str. REL606 putative electron transfer flavoprotein FixA YP_003043274.1 46598 D 413997 CDS YP_003043275.1 254160167 8175042 47383..48324 1 NC_012967.1 involved in electron transfer during carnitine metabolism; putative electron transfer flavoprotein FixB 48324 fixB 8175042 fixB Escherichia coli B str. REL606 putative electron transfer flavoprotein FixB YP_003043275.1 47383 D 413997 CDS YP_003043276.1 254160168 8175043 48375..49661 1 NC_012967.1 FAD/NAD(P)-binding domain; possibly part of an electron transfer system required for anaerobic carnitine reduction; putative oxidoreductase FixC 49661 fixC 8175043 fixC Escherichia coli B str. REL606 putative oxidoreductase FixC YP_003043276.1 48375 D 413997 CDS YP_003043277.1 254160169 8178866 49658..49945 1 NC_012967.1 similar to b0044; putative 4Fe-4S ferredoxin-type protein 49945 fixX 8178866 fixX Escherichia coli B str. REL606 putative 4Fe-4S ferredoxin-type protein YP_003043277.1 49658 D 413997 CDS YP_003043278.1 254160170 8175044 50002..51333 1 NC_012967.1 similar to b0045; putative transporter 51333 yaaU 8175044 yaaU Escherichia coli B str. REL606 putative transporter YP_003043278.1 50002 D 413997 CDS YP_003043279.1 254160171 8178305 51441..51971 1 NC_012967.1 Required for full activity of KefC, a potassium-proton antiporter; glutathione-regulated potassium-efflux system ancillary protein KefF 51971 yabF 8178305 yabF Escherichia coli B str. REL606 glutathione-regulated potassium-efflux system ancillary protein KefF YP_003043279.1 51441 D 413997 CDS YP_003043280.1 254160172 8175045 51964..53826 1 NC_012967.1 transport system that facilitates potassium-efflux; glutathione-regulated potassium-efflux system protein KefC 53826 kefC 8175045 kefC Escherichia coli B str. REL606 glutathione-regulated potassium-efflux system protein KefC YP_003043280.1 51964 D 413997 CDS YP_003043281.1 254160173 8175046 54018..54497 1 NC_012967.1 catalyzes the reduction of dihydrofolate to tetrahydrofolate; dihydrofolate reductase 54497 folA 8175046 folA Escherichia coli B str. REL606 dihydrofolate reductase YP_003043281.1 54018 D 413997 CDS YP_003043282.1 254160174 8175047 complement(54575..55417) 1 NC_012967.1 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; diadenosine tetraphosphatase 55417 apaH 8175047 apaH Escherichia coli B str. REL606 diadenosine tetraphosphatase YP_003043282.1 54575 R 413997 CDS YP_003043283.1 254160175 8175048 complement(55424..55801) 1 NC_012967.1 protein associated with Co2+ and Mg2+ efflux; ApaG protein 55801 apaG 8175048 apaG Escherichia coli B str. REL606 ApaG protein YP_003043283.1 55424 R 413997 CDS YP_003043284.1 254160176 8178867 complement(55804..56625) 1 NC_012967.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 56625 ksgA 8178867 ksgA Escherichia coli B str. REL606 dimethyladenosine transferase YP_003043284.1 55804 R 413997 CDS YP_003043285.1 254160177 8175049 complement(56622..57611) 1 NC_012967.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate); 4-hydroxythreonine-4-phosphate dehydrogenase 57611 pdxA 8175049 pdxA Escherichia coli B str. REL606 4-hydroxythreonine-4-phosphate dehydrogenase YP_003043285.1 56622 R 413997 CDS YP_003043286.1 254160178 8175050 complement(57611..58897) 1 NC_012967.1 Chaperone involved in the folding of extracytoplasmic proteins, especially OmpA, OmpF and LamB; peptidyl-prolyl cis-trans isomerase SurA 58897 surA 8175050 surA Escherichia coli B str. REL606 peptidyl-prolyl cis-trans isomerase SurA YP_003043286.1 57611 R 413997 CDS YP_003043287.1 254160179 8175051 complement(58950..61304) 1 NC_012967.1 determines N-hexane tolerance and is involved in outer membrane permeability; organic solvent tolerance protein 61304 imp 8175051 imp Escherichia coli B str. REL606 organic solvent tolerance protein YP_003043287.1 58950 R 413997 CDS YP_003043288.1 254160180 8175052 61559..62374 1 NC_012967.1 functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system; Dna-J like membrane chaperone protein 62374 djlA 8175052 djlA Escherichia coli B str. REL606 Dna-J like membrane chaperone protein YP_003043288.1 61559 D 413997 CDS YP_003043289.1 254160181 8175053 complement(62491..63150) 1 NC_012967.1 catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs; 23S rRNA/tRNA pseudouridine synthase A 63150 rluA 8175053 rluA Escherichia coli B str. REL606 23S rRNA/tRNA pseudouridine synthase A YP_003043289.1 62491 R 413997 CDS YP_003043290.1 254160182 8178306 complement(63162..66068) 1 NC_012967.1 transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA; ATP-dependent helicase HepA 66068 hepA 8178306 hepA Escherichia coli B str. REL606 ATP-dependent helicase HepA YP_003043290.1 63162 R 413997 CDS YP_003043291.1 254160183 8175054 complement(66233..68584) 1 NC_012967.1 Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C; DNA polymerase II 68584 polB 8175054 polB Escherichia coli B str. REL606 DNA polymerase II YP_003043291.1 66233 R 413997 CDS YP_003043292.1 254160184 8175055 complement(68659..69354) 1 NC_012967.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 69354 araD 8175055 araD Escherichia coli B str. REL606 L-ribulose-5-phosphate 4-epimerase YP_003043292.1 68659 R 413997 CDS YP_003043293.1 254160185 8178307 complement(69639..71141) 1 NC_012967.1 catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism; L-arabinose isomerase 71141 araA 8178307 araA Escherichia coli B str. REL606 L-arabinose isomerase YP_003043293.1 69639 R 413997 CDS YP_003043294.1 254160186 8178308 complement(71152..72852) 1 NC_012967.1 catalyzes the phosphorylation of ribulose to ribulose 5-phosphate; ribulokinase 72852 araB 8178308 araB Escherichia coli B str. REL606 ribulokinase YP_003043294.1 71152 R 413997 CDS YP_003043295.1 254160187 8175056 73191..74069 1 NC_012967.1 positive and negative regulator; regulates the araBAD and araFGH operons and other genes involved in the transport and catabolism of L-arabinose; DNA-binding transcriptional regulator AraC 74069 araC 8175056 araC Escherichia coli B str. REL606 DNA-binding transcriptional regulator AraC YP_003043295.1 73191 D 413997 CDS YP_003043296.1 254160188 8175057 74155..74919 1 NC_012967.1 similar to b0065; inner membrane protein 74919 yabI 8175057 yabI Escherichia coli B str. REL606 inner membrane protein YP_003043296.1 74155 D 413997 CDS YP_003043297.1 254160189 8175058 complement(75033..75731) 1 NC_012967.1 with TbpA and ThiP is part of the thiamine and TPP transport system; thiamine transporter ATP-binding subunit 75731 thiQ 8175058 thiQ Escherichia coli B str. REL606 thiamine transporter ATP-binding subunit YP_003043297.1 75033 R 413997 CDS YP_003043298.1 254160190 8175059 complement(75715..77325) 1 NC_012967.1 permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine; thiamine transporter membrane protein 77325 thiP 8175059 thiP Escherichia coli B str. REL606 thiamine transporter membrane protein YP_003043298.1 75715 R 413997 CDS YP_003043299.1 254160191 8178309 complement(77301..78284) 1 NC_012967.1 part of the thiamine and TPP transport system tbpA-thiPQ; thiamine transporter substrate binding subunit 78284 tbpA 8178309 tbpA Escherichia coli B str. REL606 thiamine transporter substrate binding subunit YP_003043299.1 77301 R 413997 CDS YP_003043300.1 254160192 8175060 complement(78448..80103) 1 NC_012967.1 activates sgrS under glucose-phosphate stress conditions; transcriptional regulator SgrR 80103 yabN 8175060 yabN Escherichia coli B str. REL606 transcriptional regulator SgrR YP_003043300.1 78448 R 413997 CDS YP_003043301.1 254160193 8175061 80425..81603 1 NC_012967.1 similar to b0070; broad specificity sugar efflux system 81603 setA 8175061 setA Escherichia coli B str. REL606 broad specificity sugar efflux system YP_003043301.1 80425 D 413997 CDS YP_003043302.1 254160194 8175062 complement(81652..82257) 1 NC_012967.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit 82257 leuD 8175062 leuD Escherichia coli B str. REL606 isopropylmalate isomerase small subunit YP_003043302.1 81652 R 413997 CDS YP_003043303.1 254160195 8175063 complement(82268..83668) 1 NC_012967.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit 83668 leuC 8175063 leuC Escherichia coli B str. REL606 isopropylmalate isomerase large subunit YP_003043303.1 82268 R 413997 CDS YP_003043304.1 254160196 8175064 complement(83671..84762) 1 NC_012967.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase 84762 leuB 8175064 leuB Escherichia coli B str. REL606 3-isopropylmalate dehydrogenase YP_003043304.1 83671 R 413997 CDS YP_003043305.1 254160197 8178868 complement(84762..86333) 1 NC_012967.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis; 2-isopropylmalate synthase 86333 leuA 8178868 leuA Escherichia coli B str. REL606 2-isopropylmalate synthase YP_003043305.1 84762 R 413997 CDS YP_003043306.1 254160198 8175065 complement(86426..86512) 1 NC_012967.1 involved in attenuation control of the leuABCD operon in leucine biosynthesis; leu operon leader peptide 86512 leuL 8175065 leuL Escherichia coli B str. REL606 leu operon leader peptide YP_003043306.1 86426 R 413997 CDS YP_003043307.1 254160199 8175066 87172..88116 1 NC_012967.1 activator for leuABCD operon; member of LysR family of transcriptional activators; leucine transcriptional activator 88116 leuO 8175066 leuO Escherichia coli B str. REL606 leucine transcriptional activator YP_003043307.1 87172 D 413997 CDS YP_003043308.1 254160200 8175067 88434..90158 1 NC_012967.1 catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; acetolactate synthase 3 catalytic subunit 90158 ilvI 8175067 ilvI Escherichia coli B str. REL606 acetolactate synthase 3 catalytic subunit YP_003043308.1 88434 D 413997 CDS YP_003043309.1 254160201 8175068 90161..90652 1 NC_012967.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 90652 ilvH 8175068 ilvH Escherichia coli B str. REL606 acetolactate synthase 3 regulatory subunit YP_003043309.1 90161 D 413997 CDS YP_003043310.1 254160202 8175069 90832..91836 1 NC_012967.1 binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism; DNA-binding transcriptional regulator FruR 91836 fruR 8175069 fruR Escherichia coli B str. REL606 DNA-binding transcriptional regulator FruR YP_003043310.1 90832 D 413997 CDS YP_003043311.1 254160203 8175070 92438..92896 1 NC_012967.1 MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 92896 yabB 8175070 yabB Escherichia coli B str. REL606 cell division protein MraZ YP_003043311.1 92438 D 413997 CDS YP_003043312.1 254160204 8175071 92898..93839 1 NC_012967.1 similar to b0082; S-adenosyl-methyltransferase MraW 93839 mraW 8175071 mraW Escherichia coli B str. REL606 S-adenosyl-methyltransferase MraW YP_003043312.1 92898 D 413997 CDS YP_003043313.1 254160205 8175072 93836..94201 1 NC_012967.1 membrane bound cell division protein at septum containing leucine zipper motif; cell division protein FtsL 94201 ftsL 8175072 ftsL Escherichia coli B str. REL606 cell division protein FtsL YP_003043313.1 93836 D 413997 CDS YP_003043314.1 254160206 8175073 94217..95983 1 NC_012967.1 similar to b0084; transpeptidase involved in septal peptidoglycan synthesis (penicillin-binding protein 3) 95983 ftsI 8175073 ftsI Escherichia coli B str. REL606 transpeptidase involved in septal peptidoglycan synthesis (penicillin-binding protein 3) YP_003043314.1 94217 D 413997 CDS YP_003043315.1 254160207 8175074 95970..97457 1 NC_012967.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 97457 murE 8175074 murE Escherichia coli B str. REL606 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase YP_003043315.1 95970 D 413997 CDS YP_003043316.1 254160208 8175075 97454..98812 1 NC_012967.1 similar to b0086; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase 98812 murF 8175075 murF Escherichia coli B str. REL606 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase YP_003043316.1 97454 D 413997 CDS YP_003043317.1 254160209 8175076 98806..99888 1 NC_012967.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 99888 mraY 8175076 mraY Escherichia coli B str. REL606 phospho-N-acetylmuramoyl-pentapeptide- transferase YP_003043317.1 98806 D 413997 CDS YP_003043318.1 254160210 8175077 99891..101207 1 NC_012967.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 101207 murD 8175077 murD Escherichia coli B str. REL606 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase YP_003043318.1 99891 D 413997 CDS YP_003043319.1 254160211 8175078 101207..102451 1 NC_012967.1 integral membrane protein involved in stabilizing FstZ ring during cell division; cell division protein FtsW 102451 ftsW 8175078 ftsW Escherichia coli B str. REL606 cell division protein FtsW YP_003043319.1 101207 D 413997 CDS YP_003043320.1 254160212 8175079 102448..103515 1 NC_012967.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 103515 murG 8175079 murG Escherichia coli B str. REL606 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase YP_003043320.1 102448 D 413997 CDS YP_003043321.1 254160213 8175080 103569..105044 1 NC_012967.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 105044 murC 8175080 murC Escherichia coli B str. REL606 UDP-N-acetylmuramate--L-alanine ligase YP_003043321.1 103569 D 413997 CDS YP_003043322.1 254160214 8175081 105037..105957 1 NC_012967.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanine--D-alanine ligase 105957 ddl 8175081 ddl Escherichia coli B str. REL606 D-alanine--D-alanine ligase YP_003043322.1 105037 D 413997 CDS YP_003043323.1 254160215 8178310 105959..106789 1 NC_012967.1 involved in growth of wall at septum; involved in septum formation; cell division protein FtsQ 106789 ftsQ 8178310 ftsQ Escherichia coli B str. REL606 cell division protein FtsQ YP_003043323.1 105959 D 413997 CDS YP_003043324.1 254160216 8178311 106786..108048 1 NC_012967.1 ATP-binding involved in recruitment of FtsK to Z ring; essential cell division protein; colocalizes with FtsZ through direct interaction to the septal ring structure; structurally similar to eukaryotic actin; binds directly to the cell membrane; cell division protein FtsA 108048 ftsA 8178311 ftsA Escherichia coli B str. REL606 cell division protein FtsA YP_003043324.1 106786 D 413997 CDS YP_003043325.1 254160217 8175082 108109..109260 1 NC_012967.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 109260 ftsZ 8175082 ftsZ Escherichia coli B str. REL606 cell division protein FtsZ YP_003043325.1 108109 D 413997 CDS YP_003043326.1 254160218 8178312 109361..110278 1 NC_012967.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 110278 lpxC 8178312 lpxC Escherichia coli B str. REL606 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase YP_003043326.1 109361 D 413997 CDS YP_003043327.1 254160219 8175083 110509..111021 1 NC_012967.1 secM translational pause allows for the initiation of secA translation; SecA regulator SecM 111021 yacA 8175083 yacA Escherichia coli B str. REL606 SecA regulator SecM YP_003043327.1 110509 D 413997 CDS YP_003043328.1 254160220 8175084 111083..113788 1 NC_012967.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 113788 secA 8175084 secA Escherichia coli B str. REL606 preprotein translocase subunit SecA YP_003043328.1 111083 D 413997 CDS YP_003043329.1 254160221 8175085 113848..114237 1 NC_012967.1 similar to b0099; nucleoside triphosphate pyrophosphohydrolase 114237 mutT 8175085 mutT Escherichia coli B str. REL606 nucleoside triphosphate pyrophosphohydrolase YP_003043329.1 113848 D 413997 CDS YP_003043330.1 254160222 8175086 complement(114453..114650) 1 NC_012967.1 similar to b0101; zinc-binding protein 114650 yacG 8175086 yacG Escherichia coli B str. REL606 zinc-binding protein YP_003043330.1 114453 R 413997 CDS YP_003043331.1 254160223 8175087 complement(114660..115403) 1 NC_012967.1 similar to b0102; hypothetical protein 115403 yacF 8175087 yacF Escherichia coli B str. REL606 hypothetical protein YP_003043331.1 114660 R 413997 CDS YP_003043332.1 254160224 8175088 complement(115403..116023) 1 NC_012967.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 116023 coaE 8175088 coaE Escherichia coli B str. REL606 dephospho-CoA kinase YP_003043332.1 115403 R 413997 CDS YP_003043333.1 254160225 8178869 116248..117291 1 NC_012967.1 catalyzes the NADPH-dependent deamination of GMP to inosine monophosphate; guanosine 5'-monophosphate oxidoreductase 117291 guaC 8178869 guaC Escherichia coli B str. REL606 guanosine 5'-monophosphate oxidoreductase YP_003043333.1 116248 D 413997 CDS YP_003043334.1 254160226 8175089 complement(117326..118528) 1 NC_012967.1 similar to b0106; type IV pilin biogenesis protein 118528 hofC 8175089 hofC Escherichia coli B str. REL606 type IV pilin biogenesis protein YP_003043334.1 117326 R 413997 CDS YP_003043335.1 254160227 8175090 complement(118518..119903) 1 NC_012967.1 similar to b0107; hypothetical protein 119903 hofB 8175090 hofB Escherichia coli B str. REL606 hypothetical protein YP_003043335.1 118518 R 413997 CDS YP_003043336.1 254160228 8175091 complement(119913..120353) 1 NC_012967.1 similar to b0108; putative major pilin subunit 120353 ppdD 8175091 ppdD Escherichia coli B str. REL606 putative major pilin subunit YP_003043336.1 119913 R 413997 CDS YP_003043337.1 254160229 8178313 complement(120556..121449) 1 NC_012967.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; quinolinate phosphoribosyltransferase 121449 nadC 8178313 nadC Escherichia coli B str. REL606 quinolinate phosphoribosyltransferase YP_003043337.1 120556 R 413997 CDS YP_003043338.1 254160230 8175092 121537..122088 1 NC_012967.1 similar to b0110; N-acetyl-anhydromuranmyl-L-alanine amidase 122088 ampD 8175092 ampD Escherichia coli B str. REL606 N-acetyl-anhydromuranmyl-L-alanine amidase YP_003043338.1 121537 D 413997 CDS YP_003043339.1 254160231 8178870 122085..122939 1 NC_012967.1 involved in regulation of beta-lactamase; putative signaling protein; regulatory protein AmpE 122939 ampE 8178870 ampE Escherichia coli B str. REL606 regulatory protein AmpE YP_003043339.1 122085 D 413997 CDS YP_003043340.1 254160232 8178314 complement(122982..124355) 1 NC_012967.1 similar to b0112; aromatic amino acid transporter 124355 aroP 8178314 aroP Escherichia coli B str. REL606 aromatic amino acid transporter YP_003043340.1 122982 R 413997 CDS YP_003043341.1 254160233 8175093 124896..125660 1 NC_012967.1 activates lctPRD operon; autoregulates itself through repression of pdhR-aceEF-lpdA operon; regulates pyruvate dehydrogenase complex; transcriptional regulator PdhR 125660 pdhR 8175093 pdhR Escherichia coli B str. REL606 transcriptional regulator PdhR YP_003043341.1 124896 D 413997 CDS YP_003043342.1 254160234 8178871 125821..128484 1 NC_012967.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 128484 aceE 8178871 aceE Escherichia coli B str. REL606 pyruvate dehydrogenase subunit E1 YP_003043342.1 125821 D 413997 CDS YP_003043343.1 254160235 8175094 128499..130391 1 NC_012967.1 E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains; dihydrolipoamide acetyltransferase 130391 aceF 8175094 aceF Escherichia coli B str. REL606 dihydrolipoamide acetyltransferase YP_003043343.1 128499 D 413997 CDS YP_003043344.1 254160236 8175095 130716..132140 1 NC_012967.1 E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 132140 lpdA 8175095 lpdA Escherichia coli B str. REL606 dihydrolipoamide dehydrogenase YP_003043344.1 130716 D 413997 CDS YP_003043345.1 254160237 8175096 complement(132211..134064) 1 NC_012967.1 similar to b0117; hypothetical protein 134064 yacH 8175096 yacH Escherichia coli B str. REL606 hypothetical protein YP_003043345.1 132211 R 413997 CDS YP_003043346.1 254160238 8175097 134419..137016 1 NC_012967.1 catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate; bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase 137016 acnB 8175097 acnB Escherichia coli B str. REL606 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase YP_003043346.1 134419 D 413997 CDS YP_003043347.1 254160239 8175098 137191..137553 1 NC_012967.1 similar to b0119; hypothetical protein 137553 yacL 8175098 yacL Escherichia coli B str. REL606 hypothetical protein YP_003043347.1 137191 D 413997 CDS YP_003043348.1 254160240 8175099 complement(137591..138385) 1 NC_012967.1 S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine; S-adenosylmethionine decarboxylase 138385 speD 8175099 speD Escherichia coli B str. REL606 S-adenosylmethionine decarboxylase YP_003043348.1 137591 R 413997 CDS YP_003043349.1 254160241 8178872 complement(138401..139267) 1 NC_012967.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 139267 speE 8178872 speE Escherichia coli B str. REL606 spermidine synthase YP_003043349.1 138401 R 413997 CDS YP_003043350.1 254160242 8175100 complement(139373..139720) 1 NC_012967.1 similar to b0122; hypothetical protein 139720 yacC 8175100 yacC Escherichia coli B str. REL606 hypothetical protein YP_003043350.1 139373 R 413997 CDS YP_003043351.1 254160243 8178873 139886..141436 1 NC_012967.1 laccase; copper-stimulated phenoloxidase and ferroxidase which may be involved in copper detoxification; multicopper oxidase 141436 cueO 8178873 cueO Escherichia coli B str. REL606 multicopper oxidase YP_003043351.1 139886 D 413997 CDS YP_003043352.1 254160244 8178315 complement(141638..144028) 1 NC_012967.1 similar to b0124; glucose dehydrogenase 144028 gcd 8178315 gcd Escherichia coli B str. REL606 glucose dehydrogenase YP_003043352.1 141638 R 413997 CDS YP_003043353.1 254160245 8175101 144234..144770 1 NC_012967.1 similar to b0125; hypoxanthine-guanine phosphoribosyltransferase 144770 hpt 8175101 hpt Escherichia coli B str. REL606 hypoxanthine-guanine phosphoribosyltransferase YP_003043353.1 144234 D 413997 CDS YP_003043354.1 254160246 8178874 complement(144811..145473) 1 NC_012967.1 catalyzes the interconversion of bicarbonate and carbon dioxide; carbonic anhydrase 145473 yadF 8178874 yadF Escherichia coli B str. REL606 carbonic anhydrase YP_003043354.1 144811 R 413997 CDS YP_003043355.1 254160247 8175102 145582..146508 1 NC_012967.1 similar to b0127; putative transporter subunit ATP-binding protein of ABC superfamily 146508 yadG 8175102 yadG Escherichia coli B str. REL606 putative transporter subunit ATP-binding protein of ABC superfamily YP_003043355.1 145582 D 413997 CDS YP_003043356.1 254160248 8175103 146505..147275 1 NC_012967.1 similar to b0128; putative transporter subunit membrane component of ABC superfamily 147275 yadH 8175103 yadH Escherichia coli B str. REL606 putative transporter subunit membrane component of ABC superfamily YP_003043356.1 146505 D 413997 CDS YP_003043357.1 254160249 8175104 147380..147820 1 NC_012967.1 similar to b0129; putative PTS Enzyme IIA 147820 yadI 8175104 yadI Escherichia coli B str. REL606 putative PTS Enzyme IIA YP_003043357.1 147380 D 413997 CDS YP_003043358.1 254160250 8175105 147884..149113 1 NC_012967.1 similar to b0130; putative polysaccharide deacetylase lipoprotein 149113 yadE 8175105 yadE Escherichia coli B str. REL606 putative polysaccharide deacetylase lipoprotein YP_003043358.1 147884 D 413997 CDS YP_003043359.1 254160251 8175106 complement(149117..149497) 1 NC_012967.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase 149497 panD 8175106 panD Escherichia coli B str. REL606 aspartate alpha-decarboxylase YP_003043359.1 149117 R 413997 CDS YP_003043360.1 254160252 8175107 149771..150673 1 NC_012967.1 similar to b0132; putative transposase 150673 yadD 8175107 yadD Escherichia coli B str. REL606 putative transposase YP_003043360.1 149771 D 413997 CDS YP_003043361.1 254160253 8178875 complement(150747..151598) 1 NC_012967.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase 151598 panC 8178875 panC Escherichia coli B str. REL606 pantoate--beta-alanine ligase YP_003043361.1 150747 R 413997 CDS YP_003043362.1 254160254 8175108 complement(151610..152404) 1 NC_012967.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase 152404 panB 8175108 panB Escherichia coli B str. REL606 3-methyl-2-oxobutanoate hydroxymethyltransferase YP_003043362.1 151610 R 413997 CDS YP_003043363.1 254160255 8175109 complement(152517..153863) 1 NC_012967.1 similar to b0135; putative fimbrial-like adhesin protein 153863 yadC 8175109 yadC Escherichia coli B str. REL606 putative fimbrial-like adhesin protein YP_003043363.1 152517 R 413997 CDS YP_003043364.1 254160256 8175110 complement(153844..154440) 1 NC_012967.1 similar to b0136; putative fimbrial-like adhesin protein 154440 yadK 8175110 yadK Escherichia coli B str. REL606 putative fimbrial-like adhesin protein YP_003043364.1 153844 R 413997 CDS YP_003043365.1 254160257 8175111 complement(154467..155069) 1 NC_012967.1 similar to b0137; putative fimbrial-like adhesin protein 155069 yadL 8175111 yadL Escherichia coli B str. REL606 putative fimbrial-like adhesin protein YP_003043365.1 154467 R 413997 CDS YP_003043366.1 254160258 8175112 complement(155084..155653) 1 NC_012967.1 similar to b0138; putative fimbrial-like adhesin protein 155653 yadM 8175112 yadM Escherichia coli B str. REL606 putative fimbrial-like adhesin protein YP_003043366.1 155084 R 413997 CDS YP_003043367.1 254160259 8175113 complement(155670..158270) 1 NC_012967.1 similar to the fimbrial usher protein PapC; putative outer membrane usher protein 158270 htrE 8175113 htrE Escherichia coli B str. REL606 putative outer membrane usher protein YP_003043367.1 155670 R 413997 CDS YP_003043368.1 254160260 8175114 complement(158305..159045) 1 NC_012967.1 similar to b0140; putative chaperone protein EcpD 159045 ecpD 8175114 ecpD Escherichia coli B str. REL606 putative chaperone protein EcpD YP_003043368.1 158305 R 413997 CDS YP_003043369.1 254160261 8178876 complement(159150..159734) 1 NC_012967.1 similar to b0141; putative fimbrial-like adhesin protein 159734 yadN 8178876 yadN Escherichia coli B str. REL606 putative fimbrial-like adhesin protein YP_003043369.1 159150 R 413997 CDS YP_003043370.1 254160262 8175115 complement(160104..160583) 1 NC_012967.1 catalyzes the formation of 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine and ATP; 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase 160583 folK 8175115 folK Escherichia coli B str. REL606 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase YP_003043370.1 160104 R 413997 CDS YP_003043371.1 254160263 8175116 complement(160580..161944) 1 NC_012967.1 Polymerase that creates the 3' poly(A) tail found in some mRNA's; poly(A) polymerase I 161944 pcnB 8175116 pcnB Escherichia coli B str. REL606 poly(A) polymerase I YP_003043371.1 160580 R 413997 CDS YP_003043372.1 254160264 8175117 complement(162037..162963) 1 NC_012967.1 this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu; glutamyl-Q tRNA(Asp) synthetase 162963 yadB 8175117 yadB Escherichia coli B str. REL606 glutamyl-Q tRNA(Asp) synthetase YP_003043372.1 162037 R 413997 CDS YP_003043373.1 254160265 8175118 complement(163000..163455) 1 NC_012967.1 similar to b0145; RNA polymerase-binding transcription factor 163455 dksA 8175118 dksA Escherichia coli B str. REL606 RNA polymerase-binding transcription factor YP_003043373.1 163000 R 413997 CDS YP_003043374.1 254160266 8175119 complement(163633..164337) 1 NC_012967.1 Regulatory factor involved in maltose metabolism; sugar fermentation stimulation protein A 164337 sfsA 8175119 sfsA Escherichia coli B str. REL606 sugar fermentation stimulation protein A YP_003043374.1 163633 R 413997 CDS YP_003043375.1 254160267 8175120 complement(164352..164882) 1 NC_012967.1 similar to b0147; 2'-5' RNA ligase 164882 ligT 8175120 ligT Escherichia coli B str. REL606 2'-5' RNA ligase YP_003043375.1 164352 R 413997 CDS YP_003043376.1 254160268 8175121 164956..167385 1 NC_012967.1 similar in sequence to the ATP-dependent RNA helicase HrpA; ATP-dependent RNA helicase HrpB 167385 hrpB 8175121 hrpB Escherichia coli B str. REL606 ATP-dependent RNA helicase HrpB YP_003043376.1 164956 D 413997 CDS YP_003043377.1 254160269 8178316 167581..170106 1 NC_012967.1 bifunctional periplasmic enzyme; contains transglycosylase and transpeptidase activity; major enzyme for peptidoglycan biosynthesis in Escherichia coli; transmembrane protein; forms dimers; three variants, one of which may be a degradation product, while the other appears to result from an alternative initiation site, are found within the cell; penicillin-binding protein 1b 170106 mrcB 8178316 mrcB Escherichia coli B str. REL606 penicillin-binding protein 1b YP_003043377.1 167581 D 413997 CDS YP_003043378.1 254160270 8175122 170326..172569 1 NC_012967.1 involved with the transport of ferrichrome across the outer membrane; binds the ferrichrome-iron ligand and interacts with the TonB protein; ferrichrome outer membrane transporter 172569 fhuA 8175122 fhuA Escherichia coli B str. REL606 ferrichrome outer membrane transporter YP_003043378.1 170326 D 413997 CDS YP_003043379.1 254160271 8178317 172620..173417 1 NC_012967.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; iron-hydroxamate transporter ATP-binding subunit 173417 fhuC 8178317 fhuC Escherichia coli B str. REL606 iron-hydroxamate transporter ATP-binding subunit YP_003043379.1 172620 D 413997 CDS YP_003043380.1 254160272 8178318 173417..174307 1 NC_012967.1 Part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; binds to all hydroxamate siderophores; iron-hydroxamate transporter substrate-binding subunit 174307 fhuD 8178318 fhuD Escherichia coli B str. REL606 iron-hydroxamate transporter substrate-binding subunit YP_003043380.1 173417 D 413997 CDS YP_003043381.1 254160273 8175123 174304..176286 1 NC_012967.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome; iron-hydroxamate transporter permease 176286 fhuB 8175123 fhuB Escherichia coli B str. REL606 iron-hydroxamate transporter permease YP_003043381.1 174304 D 413997 CDS YP_003043382.1 254160274 8175124 complement(176444..177724) 1 NC_012967.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase 177724 hemL 8175124 hemL Escherichia coli B str. REL606 glutamate-1-semialdehyde aminotransferase YP_003043382.1 176444 R 413997 CDS YP_003043383.1 254160275 8175125 177949..179370 1 NC_012967.1 Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation; chloride channel protein 179370 yadQ 8175125 yadQ Escherichia coli B str. REL606 chloride channel protein YP_003043383.1 177949 D 413997 CDS YP_003043384.1 254160276 8175126 179452..179796 1 NC_012967.1 essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors; iron-sulfur cluster insertion protein ErpA 179796 yadR 8175126 yadR Escherichia coli B str. REL606 iron-sulfur cluster insertion protein ErpA YP_003043384.1 179452 D 413997 CDS YP_003043385.1 254160277 8175127 complement(179843..180466) 1 NC_012967.1 similar to b0157; hypothetical protein 180466 yadS 8175127 yadS Escherichia coli B str. REL606 hypothetical protein YP_003043385.1 179843 R 413997 CDS YP_003043386.1 254160278 8175128 complement(180504..181304) 1 NC_012967.1 solute binding component of the vitamin B12 transport system BtuCDF; vitamin B12-transporter protein BtuF 181304 yadT 8175128 yadT Escherichia coli B str. REL606 vitamin B12-transporter protein BtuF YP_003043386.1 180504 R 413997 CDS YP_003043387.1 254160279 8175129 complement(181297..181995) 1 NC_012967.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 181995 pfs 8175129 pfs Escherichia coli B str. REL606 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase YP_003043387.1 181297 R 413997 CDS YP_003043388.1 254160280 8175130 182079..183596 1 NC_012967.1 forms a homotetramer; requires magnesium for activity; catalyzes the hydrolysis of dGTP to form deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase 183596 dgt 8175130 dgt Escherichia coli B str. REL606 deoxyguanosinetriphosphate triphosphohydrolase YP_003043388.1 182079 D 413997 CDS YP_003043389.1 254160281 8178319 183726..185150 1 NC_012967.1 protease Do; required at high temperature; degrades damaged proteins; serine endoprotease 185150 degP 8178319 degP Escherichia coli B str. REL606 serine endoprotease YP_003043389.1 183726 D 413997 CDS YP_003043390.1 254160282 8175131 185305..186462 1 NC_012967.1 regulates the expression of the operons for the enzymes involved in galactarate, glucarate and glycerate utilization; carbohydrate diacid transcriptional activator CdaR 186462 cdaR 8175131 cdaR Escherichia coli B str. REL606 carbohydrate diacid transcriptional activator CdaR YP_003043390.1 185305 D 413997 CDS YP_003043391.1 254160283 8178320 complement(186551..186937) 1 NC_012967.1 similar to b0163; hypothetical protein 186937 yaeH 8178320 yaeH Escherichia coli B str. REL606 hypothetical protein YP_003043391.1 186551 R 413997 CDS YP_003043392.1 254160284 8178321 complement(187099..187911) 1 NC_012967.1 similar to b0164; phosphodiesterase YaeI 187911 yaeI 8178321 yaeI Escherichia coli B str. REL606 phosphodiesterase YaeI YP_003043392.1 187099 R 413997 CDS YP_003043393.1 254160285 8175132 complement(187965..188789) 1 NC_012967.1 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 188789 dapD 8175132 dapD Escherichia coli B str. REL606 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase YP_003043393.1 187965 R 413997 CDS YP_003043394.1 254160286 8175133 complement(188820..191492) 1 NC_012967.1 catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein; PII uridylyl-transferase 191492 glnD 8175133 glnD Escherichia coli B str. REL606 PII uridylyl-transferase YP_003043394.1 188820 R 413997 CDS YP_003043395.1 254160287 8175134 complement(191554..192348) 1 NC_012967.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase 192348 map 8175134 map Escherichia coli B str. REL606 methionine aminopeptidase YP_003043395.1 191554 R 413997 CDS YP_003043396.1 254160288 8175135 192716..193441 1 NC_012967.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 193441 rpsB 8175135 rpsB Escherichia coli B str. REL606 30S ribosomal protein S2 YP_003043396.1 192716 D 413997 CDS YP_003043397.1 254160289 8175136 193699..194550 1 NC_012967.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 194550 tsf 8175136 tsf Escherichia coli B str. REL606 elongation factor Ts YP_003043397.1 193699 D 413997 CDS YP_003043398.1 254160290 8175137 194697..195422 1 NC_012967.1 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 195422 pyrH 8175137 pyrH Escherichia coli B str. REL606 uridylate kinase YP_003043398.1 194697 D 413997 CDS YP_003043399.1 254160291 8175138 195714..196271 1 NC_012967.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 196271 frr 8175138 frr Escherichia coli B str. REL606 ribosome recycling factor YP_003043399.1 195714 D 413997 CDS YP_003043400.1 254160292 8178322 196363..197559 1 NC_012967.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 197559 ispC 8178322 ispC Escherichia coli B str. REL606 1-deoxy-D-xylulose 5-phosphate reductoisomerase YP_003043400.1 196363 D 413997 CDS YP_003043401.1 254160293 8175139 197745..198506 1 NC_012967.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 198506 uppS 8175139 uppS Escherichia coli B str. REL606 undecaprenyl pyrophosphate synthase YP_003043401.1 197745 D 413997 CDS YP_003043402.1 254160294 8175140 198519..199376 1 NC_012967.1 catalyzes the synthesis of CDP-diglyceride from CTP and phosphatidate; CDP-diglyceride synthase 199376 cdsA 8175140 cdsA Escherichia coli B str. REL606 CDP-diglyceride synthase YP_003043402.1 198519 D 413997 CDS YP_003043403.1 254160295 8178323 199388..200740 1 NC_012967.1 catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response; zinc metallopeptidase RseP 200740 yaeL 8178323 yaeL Escherichia coli B str. REL606 zinc metallopeptidase RseP YP_003043403.1 199388 D 413997 CDS YP_003043404.1 254160296 8175141 200770..203202 1 NC_012967.1 part of a complex with YfgL, YfiO, and NlpB involved in outer membrane protein biosynthesis; involved in the assembly of outer membrane proteins; outer membrane protein assembly factor YaeT 203202 yaeT 8175141 yaeT Escherichia coli B str. REL606 outer membrane protein assembly factor YaeT YP_003043404.1 200770 D 413997 CDS YP_003043405.1 254160297 8175142 203324..203809 1 NC_012967.1 similar to b0178; periplasmic chaperone 203809 hlpA 8175142 hlpA Escherichia coli B str. REL606 periplasmic chaperone YP_003043405.1 203324 D 413997 CDS YP_003043406.1 254160298 8175143 203813..204838 1 NC_012967.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 204838 lpxD 8175143 lpxD Escherichia coli B str. REL606 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase YP_003043406.1 203813 D 413997 CDS YP_003043407.1 254160299 8175144 204943..205398 1 NC_012967.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 205398 fabZ 8175144 fabZ Escherichia coli B str. REL606 (3R)-hydroxymyristoyl-ACP dehydratase YP_003043407.1 204943 D 413997 CDS YP_003043408.1 254160300 8175145 205402..206190 1 NC_012967.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 206190 lpxA 8175145 lpxA Escherichia coli B str. REL606 UDP-N-acetylglucosamine acyltransferase YP_003043408.1 205402 D 413997 CDS YP_003043409.1 254160301 8175146 206190..207338 1 NC_012967.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; lipid-A-disaccharide synthase 207338 lpxB 8175146 lpxB Escherichia coli B str. REL606 lipid-A-disaccharide synthase YP_003043409.1 206190 D 413997 CDS YP_003043410.1 254160302 8178877 207335..207931 1 NC_012967.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 207931 rnhB 8178877 rnhB Escherichia coli B str. REL606 ribonuclease HII YP_003043410.1 207335 D 413997 CDS YP_003043411.1 254160303 8178878 207968..211450 1 NC_012967.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 211450 dnaE 8178878 dnaE Escherichia coli B str. REL606 DNA polymerase III subunit alpha YP_003043411.1 207968 D 413997 CDS YP_003043412.1 254160304 8175147 211463..212422 1 NC_012967.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 212422 accA 8175147 accA Escherichia coli B str. REL606 acetyl-CoA carboxylase carboxyltransferase subunit alpha YP_003043412.1 211463 D 413997 CDS YP_003043413.1 254160305 8175148 212521..214662 1 NC_012967.1 similar to b0186; lysine decarboxylase 2, constitutive 214662 ldcC 8175148 ldcC Escherichia coli B str. REL606 lysine decarboxylase 2, constitutive YP_003043413.1 212521 D 413997 CDS YP_003043414.1 254160306 8175149 214719..215108 1 NC_012967.1 similar to b0187; hypothetical protein 215108 yaeR 8175149 yaeR Escherichia coli B str. REL606 hypothetical protein YP_003043414.1 214719 D 413997 CDS YP_003043415.1 254160307 8175150 215173..216471 1 NC_012967.1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU; ATP-dependent; responsible for modifying the wobble-base of the CAU anticodon of tRNAIle such that it exhibits proper recognition of the AUA codon rather than the AUG codon and is in turn properly recognized by isoleucyl-tRNA synthetase; tRNA(Ile)-lysidine synthetase 216471 tilS 8175150 tilS Escherichia coli B str. REL606 tRNA(Ile)-lysidine synthetase YP_003043415.1 215173 D 413997 CDS YP_003043416.1 254160308 8175151 complement(216520..216774) 1 NC_012967.1 Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination; Rho-binding antiterminator 216774 rof 8175151 rof Escherichia coli B str. REL606 Rho-binding antiterminator YP_003043416.1 216520 R 413997 CDS YP_003043417.1 254160309 8175152 complement(216767..216967) 1 NC_012967.1 similar to b4406; hypothetical protein 216967 yaeP 8175152 yaeP Escherichia coli B str. REL606 hypothetical protein YP_003043417.1 216767 R 413997 CDS YP_003043418.1 254160310 8178879 217133..217678 1 NC_012967.1 similar to b0190; hypothetical protein 217678 yaeQ 8178879 yaeQ Escherichia coli B str. REL606 hypothetical protein YP_003043418.1 217133 D 413997 CDS YP_003043419.1 254160311 8175153 217675..218097 1 NC_012967.1 similar to b0191; peptidyl-tRNA hydrolase domain protein 218097 yaeJ 8175153 yaeJ Escherichia coli B str. REL606 peptidyl-tRNA hydrolase domain protein YP_003043419.1 217675 D 413997 CDS YP_003043420.1 254160312 8175154 218111..218821 1 NC_012967.1 similar to b0192; lipoprotein involved with copper homeostasis and adhesion 218821 cutF 8175154 cutF Escherichia coli B str. REL606 lipoprotein involved with copper homeostasis and adhesion YP_003043420.1 218111 D 413997 CDS YP_003043421.1 254160313 8178880 complement(219021..219845) 1 NC_012967.1 similar to b0193; hypothetical protein 219845 yaeF 8178880 yaeF Escherichia coli B str. REL606 hypothetical protein YP_003043421.1 219021 R 413997 CDS YP_003043422.1 254160314 8175155 complement(219898..221616) 1 NC_012967.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 221616 proS 8175155 proS Escherichia coli B str. REL606 prolyl-tRNA synthetase YP_003043422.1 219898 R 413997 CDS YP_003043423.1 254160315 8175156 complement(221727..222434) 1 NC_012967.1 similar to b0195; hypothetical protein 222434 yaeB 8175156 yaeB Escherichia coli B str. REL606 hypothetical protein YP_003043423.1 221727 R 413997 CDS YP_003043424.1 254160316 8175157 complement(222431..222835) 1 NC_012967.1 similar to b0196; outer membrane lipoprotein 222835 rcsF 8175157 rcsF Escherichia coli B str. REL606 outer membrane lipoprotein YP_003043424.1 222431 R 413997 CDS YP_003043425.1 254160317 8175158 complement(222953..223768) 1 NC_012967.1 similar to b0197; DL-methionine transporter substrate-binding subunit 223768 metQ 8175158 metQ Escherichia coli B str. REL606 DL-methionine transporter substrate-binding subunit YP_003043425.1 222953 R 413997 CDS YP_003043426.1 254160318 8175159 complement(223808..224461) 1 NC_012967.1 part of the MetNIQ methionine uptake system; DL-methionine transporter permease 224461 metI 8175159 metI Escherichia coli B str. REL606 DL-methionine transporter permease YP_003043426.1 223808 R 413997 CDS YP_003043427.1 254160319 8175160 complement(224454..225485) 1 NC_012967.1 part of the metNIQ transport system for methionine; DL-methionine transporter ATP-binding subunit 225485 metN 8175160 metN Escherichia coli B str. REL606 DL-methionine transporter ATP-binding subunit YP_003043427.1 224454 R 413997 CDS YP_003043428.1 254160320 8178881 225673..226245 1 NC_012967.1 Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate; D,D-heptose 1,7-bisphosphate phosphatase 226245 gmhB 8178881 gmhB Escherichia coli B str. REL606 D,D-heptose 1,7-bisphosphate phosphatase YP_003043428.1 225673 D 413997 CDS YP_003043429.1 254160321 8175165 232091..232894 1 NC_012967.1 catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; 2,5-diketo-D-gluconate reductase B 232894 dkgB 8175165 dkgB Escherichia coli B str. REL606 2,5-diketo-D-gluconate reductase B YP_003043429.1 232091 D 413997 CDS YP_003043430.1 254160322 8175166 complement(232891..233805) 1 NC_012967.1 similar to b0208; putative DNA-binding transcriptional regulator 233805 yafC 8175166 yafC Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003043430.1 232891 R 413997 CDS YP_003043431.1 254160323 8175167 234046..234846 1 NC_012967.1 similar to b0209; hypothetical protein 234846 yafD 8175167 yafD Escherichia coli B str. REL606 hypothetical protein YP_003043431.1 234046 D 413997 CDS YP_003043432.1 254160324 8175168 234850..235473 1 NC_012967.1 similar to b0210; putative S-adenosyl-L-methionine-dependent methyltransferase 235473 yafE 8175168 yafE Escherichia coli B str. REL606 putative S-adenosyl-L-methionine-dependent methyltransferase YP_003043432.1 234850 D 413997 CDS YP_003043433.1 254160325 8175169 complement(235521..236879) 1 NC_012967.1 catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; may play a role in recycling muropeptides during cell division and/or cell elongation; in Helicobacter pylori MltD is a endolytic transglycosylase involved mainly in the rearrangement of the peptidoglycan layer of the bacterial cell wall; membrane-bound lytic murein transglycosylase D 236879 mltD 8175169 mltD Escherichia coli B str. REL606 membrane-bound lytic murein transglycosylase D YP_003043433.1 235521 R 413997 CDS YP_003043434.1 254160326 8178324 complement(236951..237706) 1 NC_012967.1 catalyzes the hydrolysis of S-D-lactoylglutathione to D-lactic acid and reduced glutathione; plays an important role in cellular detoxification using glutathione; hydroxyacylglutathione hydrolase 237706 gloB 8178324 gloB Escherichia coli B str. REL606 hydroxyacylglutathione hydrolase YP_003043434.1 236951 R 413997 CDS YP_003043435.1 254160327 8175170 237740..238462 1 NC_012967.1 similar to b0213; putative S-adenosyl-L-methionine-dependent methyltransferase 238462 yafS 8175170 yafS Escherichia coli B str. REL606 putative S-adenosyl-L-methionine-dependent methyltransferase YP_003043435.1 237740 D 413997 CDS YP_003043436.1 254160328 8178325 complement(238459..238926) 1 NC_012967.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease H 238926 rnhA 8178325 rnhA Escherichia coli B str. REL606 ribonuclease H YP_003043436.1 238459 R 413997 CDS YP_003043437.1 254160329 8178326 238991..239722 1 NC_012967.1 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 239722 dnaQ 8178326 dnaQ Escherichia coli B str. REL606 DNA polymerase III subunit epsilon YP_003043437.1 238991 D 413997 CDS YP_003043438.1 254160330 8175172 240261..241046 1 NC_012967.1 similar to b0217; putative aminopeptidase 241046 yafT 8175172 yafT Escherichia coli B str. REL606 putative aminopeptidase YP_003043438.1 240261 D 413997 CDS YP_003043439.1 254160331 8178884 241312..241587 1 NC_012967.1 IS1 protein InsA 241587 insA-2 8178884 insA-2 Escherichia coli B str. REL606 IS1 protein InsA YP_003043439.1 241312 D 413997 CDS YP_003043440.1 254160332 8178885 241506..242009 1 NC_012967.1 IS1 protein InsB 242009 insB-2 8178885 insB-2 Escherichia coli B str. REL606 IS1 protein InsB YP_003043440.1 241506 D 413997 CDS YP_003043441.1 254160333 8175173 242011..242382 1 NC_012967.1 hypothetical protein 242382 8175173 ECB_00212 Escherichia coli B str. REL606 hypothetical protein YP_003043441.1 242011 D 413997 CDS YP_003043442.1 254160334 8178327 242813..243949 1 NC_012967.1 similar to b3484; putative transposase 243949 yhhI-1 8178327 yhhI-1 Escherichia coli B str. REL606 putative transposase YP_003043442.1 242813 D 413997 CDS YP_003043443.1 254160335 8175174 complement(243990..244760) 1 NC_012967.1 similar to b0219; hypothetical protein 244760 yafV 8175174 yafV Escherichia coli B str. REL606 hypothetical protein YP_003043443.1 243990 R 413997 CDS YP_003043444.1 254160336 8175175 244914..245387 1 NC_012967.1 inactivates vertebrate C-type lysozyme; C-lysozyme inhibitor 245387 ykfE 8175175 ykfE Escherichia coli B str. REL606 C-lysozyme inhibitor YP_003043444.1 244914 D 413997 CDS YP_003043445.1 254160337 8175176 complement(245430..247874) 1 NC_012967.1 functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA; acyl-CoA dehydrogenase 247874 fadE 8175176 fadE Escherichia coli B str. REL606 acyl-CoA dehydrogenase YP_003043445.1 245430 R 413997 CDS YP_003043446.1 254160338 8175177 248114..248692 1 NC_012967.1 catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate; phosphoheptose isomerase 248692 gmhA 8175177 gmhA Escherichia coli B str. REL606 phosphoheptose isomerase YP_003043446.1 248114 D 413997 CDS YP_003043447.1 254160339 8175178 248898..249665 1 NC_012967.1 similar to b0223; putative amidotransfease 249665 yafJ 8175178 yafJ Escherichia coli B str. REL606 putative amidotransfease YP_003043447.1 248898 D 413997 CDS YP_003043448.1 254160340 8175179 complement(249636..250376) 1 NC_012967.1 similar to b0224; hypothetical protein 250376 yafK 8175179 yafK Escherichia coli B str. REL606 hypothetical protein YP_003043448.1 249636 R 413997 CDS YP_003043449.1 254160341 8178328 complement(250532..250810) 1 NC_012967.1 similar to b0225; putative toxin of the YafQ-DinJ toxin-antitoxin system 250810 yafQ 8178328 yafQ Escherichia coli B str. REL606 putative toxin of the YafQ-DinJ toxin-antitoxin system YP_003043449.1 250532 R 413997 CDS YP_003043450.1 254160342 8175180 complement(250813..251073) 1 NC_012967.1 similar to b0226; putative antitoxin of YafQ-DinJ toxin-antitoxin system 251073 dinJ 8175180 dinJ Escherichia coli B str. REL606 putative antitoxin of YafQ-DinJ toxin-antitoxin system YP_003043450.1 250813 R 413997 CDS YP_003043451.1 254160343 8175181 251283..252032 1 NC_012967.1 similar to b0227; putative lipoprotein and C40 family peptidase 252032 yafL 8175181 yafL Escherichia coli B str. REL606 putative lipoprotein and C40 family peptidase YP_003043451.1 251283 D 413997 CDS YP_003043452.1 254160344 8178329 252208..252705 1 NC_012967.1 similar to b0228; hypothetical protein 252705 yafM 8178329 yafM Escherichia coli B str. REL606 hypothetical protein YP_003043452.1 252208 D 413997 CDS YP_003043453.1 254160345 8175183 255461..256516 1 NC_012967.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 256516 dinB 8175183 dinB Escherichia coli B str. REL606 DNA polymerase IV YP_003043453.1 255461 D 413997 CDS YP_003043454.1 254160346 8175184 256568..256861 1 NC_012967.1 similar to b0232; putative antitoxin of the YafO-YafN toxin-antitoxin system 256861 yafN 8175184 yafN Escherichia coli B str. REL606 putative antitoxin of the YafO-YafN toxin-antitoxin system YP_003043454.1 256568 D 413997 CDS YP_003043455.1 254160347 8175185 256864..257262 1 NC_012967.1 YafO overproduction induces toxicity; it is believed to be the toxin of a toxin-antitoxin pair; unknown function; putative toxin YafO 257262 yafO 8175185 yafO Escherichia coli B str. REL606 putative toxin YafO YP_003043455.1 256864 D 413997 CDS YP_003043456.1 254160348 8175186 257272..257724 1 NC_012967.1 similar to b0234; hypothetical protein 257724 yafP 8175186 yafP Escherichia coli B str. REL606 hypothetical protein YP_003043456.1 257272 D 413997 CDS YP_003043457.1 254160349 8175187 257958..258224 1 NC_012967.1 similar to b0235; hypothetical protein 258224 ykfJ 8175187 ykfJ Escherichia coli B str. REL606 hypothetical protein YP_003043457.1 257958 D 413997 CDS YP_003043458.1 254160350 8175188 258193..258693 1 NC_012967.1 similar to release factor 1 and 2; peptide chain release factor-like protein 258693 prfH 8175188 prfH Escherichia coli B str. REL606 peptide chain release factor-like protein YP_003043458.1 258193 D 413997 CDS YP_003043459.1 254160351 8178331 complement(258750..260207) 1 NC_012967.1 similar to b0237; aminoacyl-histidine dipeptidase 260207 pepD 8178331 pepD Escherichia coli B str. REL606 aminoacyl-histidine dipeptidase YP_003043459.1 258750 R 413997 CDS YP_003043460.1 254160352 8175189 260468..260926 1 NC_012967.1 catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively; xanthine-guanine phosphoribosyltransferase 260926 gpt 8175189 gpt Escherichia coli B str. REL606 xanthine-guanine phosphoribosyltransferase YP_003043460.1 260468 D 413997 CDS YP_003043461.1 254160353 8175190 261018..262262 1 NC_012967.1 forms a 1:1 complex with the unphosphorylated from of enzyme IIAGlc; FrsA may promote fermentation; fermentation/respiration switch protein 262262 frsA 8175190 frsA Escherichia coli B str. REL606 fermentation/respiration switch protein YP_003043461.1 261018 D 413997 CDS YP_003043462.1 254160354 8178332 262320..262721 1 NC_012967.1 involved in the expression of csgBA which is involved in curli formation; interacts with sigmaS; DNA-binding transcriptional regulator Crl 262721 crl 8178332 crl Escherichia coli B str. REL606 DNA-binding transcriptional regulator Crl YP_003043462.1 262320 D 413997 CDS YP_003043463.1 254160355 8175191 262847..263122 1 NC_012967.1 IS1 protein InsA 263122 insA-3 8175191 insA-3 Escherichia coli B str. REL606 IS1 protein InsA YP_003043463.1 262847 D 413997 CDS YP_003043464.1 254160356 8175192 263041..263544 1 NC_012967.1 IS1 protein InsB 263544 insB-3 8175192 insB-3 Escherichia coli B str. REL606 IS1 protein InsB YP_003043464.1 263041 D 413997 CDS YP_003043465.1 254160357 8175193 complement(263555..264592) 1 NC_012967.1 similar to b0241; outer membrane phosphoporin protein E 264592 phoE 8175193 phoE Escherichia coli B str. REL606 outer membrane phosphoporin protein E YP_003043465.1 263555 R 413997 CDS YP_003043466.1 254160358 8175194 264880..265983 1 NC_012967.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 265983 proB 8175194 proB Escherichia coli B str. REL606 gamma-glutamyl kinase YP_003043466.1 264880 D 413997 CDS YP_003043467.1 254160359 8175195 265995..267248 1 NC_012967.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 267248 proA 8175195 proA Escherichia coli B str. REL606 gamma-glutamyl phosphate reductase YP_003043467.1 265995 D 413997 CDS YP_003043468.1 254160360 8178886 complement(267565..267975) 1 NC_012967.1 similar to b0282; putative transcriptional regulator 267975 yagP 8178886 yagP Escherichia coli B str. REL606 putative transcriptional regulator YP_003043468.1 267565 R 413997 CDS YP_003043469.1 254160361 8175197 complement(267954..268910) 1 NC_012967.1 similar to b0283; hypothetical protein 268910 yagQ 8175197 yagQ Escherichia coli B str. REL606 hypothetical protein YP_003043469.1 267954 R 413997 CDS YP_003043470.1 254160362 8175198 complement(268920..271118) 1 NC_012967.1 similar to b0284; putative oxidoreductase with molybdenum-binding domain 271118 yagR 8175198 yagR Escherichia coli B str. REL606 putative oxidoreductase with molybdenum-binding domain YP_003043470.1 268920 R 413997 CDS YP_003043471.1 254160363 8175199 complement(271115..272071) 1 NC_012967.1 similar to b0285; putative oxidoreductase with FAD-binding domain 272071 yagS 8175199 yagS Escherichia coli B str. REL606 putative oxidoreductase with FAD-binding domain YP_003043471.1 271115 R 413997 CDS YP_003043472.1 254160364 8178333 complement(272068..272757) 1 NC_012967.1 similar to b0286; putative xanthine dehydrogenase iron-sulfur-binding subunit 272757 yagT 8178333 yagT Escherichia coli B str. REL606 putative xanthine dehydrogenase iron-sulfur-binding subunit YP_003043472.1 272068 R 413997 CDS YP_003043473.1 254160365 8175200 273174..273788 1 NC_012967.1 similar to b0287; inner membrane protein 273788 yagU 8175200 yagU Escherichia coli B str. REL606 inner membrane protein YP_003043473.1 273174 D 413997 CDS YP_003043474.1 254160366 8178887 complement(274035..274364) 1 NC_012967.1 similar to b0288; putative ferredoxin 274364 ykgJ 8178887 ykgJ Escherichia coli B str. REL606 putative ferredoxin YP_003043474.1 274035 R 413997 CDS YP_003043475.1 254160367 8175201 complement(274677..275387) 1 NC_012967.1 similar to b0289; hypothetical protein 275387 yagV 8175201 yagV Escherichia coli B str. REL606 hypothetical protein YP_003043475.1 274677 R 413997 CDS YP_003043476.1 254160368 8175202 complement(275356..276999) 1 NC_012967.1 similar to b0290; putative receptor 276999 yagW 8175202 yagW Escherichia coli B str. REL606 putative receptor YP_003043476.1 275356 R 413997 CDS YP_003043477.1 254160369 8178334 complement(276989..279514) 1 NC_012967.1 similar to b0291; putative aromatic compound dioxygenase 279514 yagX 8178334 yagX Escherichia coli B str. REL606 putative aromatic compound dioxygenase YP_003043477.1 276989 R 413997 CDS YP_003043478.1 254160370 8178888 complement(279540..280208) 1 NC_012967.1 similar to b0292; hypothetical protein 280208 yagY 8178888 yagY Escherichia coli B str. REL606 hypothetical protein YP_003043478.1 279540 R 413997 CDS YP_003043479.1 254160371 8175203 complement(280266..280901) 1 NC_012967.1 similar to b0293; hypothetical protein 280901 yagZ 8175203 yagZ Escherichia coli B str. REL606 hypothetical protein YP_003043479.1 280266 R 413997 CDS YP_003043480.1 254160372 8175204 complement(280927..281517) 1 NC_012967.1 similar to b0294; putative regulator 281517 ykgK 8175204 ykgK Escherichia coli B str. REL606 putative regulator YP_003043480.1 280927 R 413997 CDS YP_003043481.1 254160373 8178335 282292..282519 1 NC_012967.1 similar to b0295; hypothetical protein 282519 ykgL 8178335 ykgL Escherichia coli B str. REL606 hypothetical protein YP_003043481.1 282292 D 413997 CDS YP_003043482.1 254160374 8175205 complement(282694..282957) 1 NC_012967.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 type B 282957 rpmE2 8175205 rpmE2 Escherichia coli B str. REL606 50S ribosomal protein L31 type B YP_003043482.1 282694 R 413997 CDS YP_003043483.1 254160375 8178889 284537..288793 1 NC_012967.1 similar to b0297; attaching and effacing protein, pathogenesis factor 288793 eaeH 8178889 eaeH Escherichia coli B str. REL606 attaching and effacing protein, pathogenesis factor YP_003043483.1 284537 D 413997 CDS YP_003043484.1 254160376 8175206 complement(288933..289784) 1 NC_012967.1 similar to b0300; putative DNA-binding transcriptional regulator 289784 ykgA 8175206 ykgA Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003043484.1 288933 R 413997 CDS YP_003043485.1 254160377 8175207 complement(290375..290968) 1 NC_012967.1 similar to b0301; inner membrane protein 290968 ykgB 8175207 ykgB Escherichia coli B str. REL606 inner membrane protein YP_003043485.1 290375 R 413997 CDS YP_003043486.1 254160378 8175208 complement(290980..291216) 1 NC_012967.1 similar to b0303; hypothetical protein 291216 ykgI 8175208 ykgI Escherichia coli B str. REL606 hypothetical protein YP_003043486.1 290980 R 413997 CDS YP_003043487.1 254160379 8175209 complement(291325..292650) 1 NC_012967.1 Involved in disulfide oxidoreductase activity and electron transport; pyridine nucleotide-disulfide oxidoreductase 292650 ykgC 8175209 ykgC Escherichia coli B str. REL606 pyridine nucleotide-disulfide oxidoreductase YP_003043487.1 291325 R 413997 CDS YP_003043488.1 254160380 8175210 292876..293730 1 NC_012967.1 similar to b0305; putative DNA-binding transcriptional regulator 293730 ykgD 8175210 ykgD Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003043488.1 292876 D 413997 CDS YP_003043489.1 254160381 8175211 294257..294976 1 NC_012967.1 similar to b0306; putative oxidoreductase 294976 ykgE 8175211 ykgE Escherichia coli B str. REL606 putative oxidoreductase YP_003043489.1 294257 D 413997 CDS YP_003043490.1 254160382 8175212 294987..296414 1 NC_012967.1 similar to b0307; putative amino acid dehydrogenase with NAD(P)-binding domain and ferridoxin-like domain 296414 ykgF 8175212 ykgF Escherichia coli B str. REL606 putative amino acid dehydrogenase with NAD(P)-binding domain and ferridoxin-like domain YP_003043490.1 294987 D 413997 CDS YP_003043491.1 254160383 8175213 296407..297102 1 NC_012967.1 similar to b0308; putative transporter 297102 ykgG 8175213 ykgG Escherichia coli B str. REL606 putative transporter YP_003043491.1 296407 D 413997 CDS YP_003043492.1 254160384 8178336 complement(297057..297269) 1 NC_012967.1 similar to b0309; deleted entry from K-12 MG1655; hypothetical protein 297269 8178336 ECB_00265 Escherichia coli B str. REL606 hypothetical protein YP_003043492.1 297057 R 413997 CDS YP_003043493.1 254160385 8175214 complement(297345..298013) 1 NC_012967.1 similar to b0310; putative inner membrane protein 298013 ykgH 8175214 ykgH Escherichia coli B str. REL606 putative inner membrane protein YP_003043493.1 297345 R 413997 CDS YP_003043494.1 254160386 8175215 complement(298226..299896) 1 NC_012967.1 catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine; choline dehydrogenase 299896 betA 8175215 betA Escherichia coli B str. REL606 choline dehydrogenase YP_003043494.1 298226 R 413997 CDS YP_003043495.1 254160387 8175216 complement(299910..301382) 1 NC_012967.1 catalyzes the formation of betaine from betaine aldehyde; betaine aldehyde dehydrogenase 301382 betB 8175216 betB Escherichia coli B str. REL606 betaine aldehyde dehydrogenase YP_003043495.1 299910 R 413997 CDS YP_003043496.1 254160388 8178337 complement(301396..301983) 1 NC_012967.1 HTH-type; bet1; Repressor involved in choline regulation of the bet genes; transcriptional regulator BetI 301983 betI 8178337 betI Escherichia coli B str. REL606 transcriptional regulator BetI YP_003043496.1 301396 R 413997 CDS YP_003043497.1 254160389 8175217 302112..304145 1 NC_012967.1 proton-motive-force-driven choline transporter; choline transport protein BetT 304145 betT 8175217 betT Escherichia coli B str. REL606 choline transport protein BetT YP_003043497.1 302112 D 413997 CDS YP_003043498.1 254160390 8178338 305020..306108 1 NC_012967.1 similar to b0315; putative DNA-binding transcriptional regulator 306108 yahA 8178338 yahA Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003043498.1 305020 D 413997 CDS YP_003043499.1 254160391 8175218 complement(306150..307082) 1 NC_012967.1 similar to b0316; putative DNA-binding transcriptional regulator 307082 yahB 8175218 yahB Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003043499.1 306150 R 413997 CDS YP_003043500.1 254160392 8175219 complement(307174..307671) 1 NC_012967.1 similar to b0317; putative inner membrane protein 307671 yahC 8175219 yahC Escherichia coli B str. REL606 putative inner membrane protein YP_003043500.1 307174 R 413997 CDS YP_003043501.1 254160393 8178339 307929..308534 1 NC_012967.1 similar to b0318; putative transcriptional regulator with ankyrin domain 308534 yahD 8178339 yahD Escherichia coli B str. REL606 putative transcriptional regulator with ankyrin domain YP_003043501.1 307929 D 413997 CDS YP_003043502.1 254160394 8175220 308574..309437 1 NC_012967.1 similar to b0319; hypothetical protein 309437 yahE 8175220 yahE Escherichia coli B str. REL606 hypothetical protein YP_003043502.1 308574 D 413997 CDS YP_003043503.1 254160395 8175221 309427..310974 1 NC_012967.1 similar to b0320; putative acyl-CoA synthetase with NAD(P)-binding domain and succinyl-CoA synthetase domain 310974 yahF 8175221 yahF Escherichia coli B str. REL606 putative acyl-CoA synthetase with NAD(P)-binding domain and succinyl-CoA synthetase domain YP_003043503.1 309427 D 413997 CDS YP_003043504.1 254160396 8178890 310974..312392 1 NC_012967.1 similar to b0321; hypothetical protein 312392 yahG 8178890 yahG Escherichia coli B str. REL606 hypothetical protein YP_003043504.1 310974 D 413997 CDS YP_003043505.1 254160397 8175222 312814..313764 1 NC_012967.1 similar to b0323; putative carbamate kinase 313764 yahI 8175222 yahI Escherichia coli B str. REL606 putative carbamate kinase YP_003043505.1 312814 D 413997 CDS YP_003043506.1 254160398 8175223 313774..315156 1 NC_012967.1 metallo-dependent hydrolase superfamily; deaminase with metallo-dependent hydrolase domain; putative deaminase 315156 yahJ 8175223 yahJ Escherichia coli B str. REL606 putative deaminase YP_003043506.1 313774 D 413997 CDS YP_003043507.1 254160399 8175224 315533..316582 1 NC_012967.1 similar to b0325; putative oxidoreductase, Zn-dependent and NAD(P)-binding 316582 yahK 8175224 yahK Escherichia coli B str. REL606 putative oxidoreductase, Zn-dependent and NAD(P)-binding YP_003043507.1 315533 D 413997 CDS YP_003043508.1 254160400 8175225 316826..317641 1 NC_012967.1 similar to b0326; hypothetical protein 317641 yahL 8175225 yahL Escherichia coli B str. REL606 hypothetical protein YP_003043508.1 316826 D 413997 CDS YP_003043509.1 254160401 8175226 318054..318299 1 NC_012967.1 similar to b0327; hypothetical protein 318299 yahM 8175226 yahM Escherichia coli B str. REL606 hypothetical protein YP_003043509.1 318054 D 413997 CDS YP_003043510.1 254160402 8175227 complement(318316..318987) 1 NC_012967.1 similar to b0328; neutral amino-acid efflux system 318987 yahN 8175227 yahN Escherichia coli B str. REL606 neutral amino-acid efflux system YP_003043510.1 318316 R 413997 CDS YP_003043511.1 254160403 8175228 319134..319409 1 NC_012967.1 similar to b0329; hypothetical protein 319409 yahO 8175228 yahO Escherichia coli B str. REL606 hypothetical protein YP_003043511.1 319134 D 413997 CDS YP_003043512.1 254160404 8175229 complement(319507..321093) 1 NC_012967.1 similar to b0330; DNA-binding transcriptional activator 321093 prpR 8175229 prpR Escherichia coli B str. REL606 DNA-binding transcriptional activator YP_003043512.1 319507 R 413997 CDS YP_003043513.1 254160405 8175230 321332..322222 1 NC_012967.1 catalyzes the formation of pyruvate and succinate from 2-methylisocitrate; 2-methylisocitrate lyase 322222 prpB 8175230 prpB Escherichia coli B str. REL606 2-methylisocitrate lyase YP_003043513.1 321332 D 413997 CDS YP_003043514.1 254160406 8175231 322662..323831 1 NC_012967.1 catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity; methylcitrate synthase 323831 prpC 8175231 prpC Escherichia coli B str. REL606 methylcitrate synthase YP_003043514.1 322662 D 413997 CDS YP_003043515.1 254160407 8175232 323865..325316 1 NC_012967.1 functions in propionate metabolism; involved in isomerization of (2S,3S)-methylcitrate to (2R,3S)-methylisocitrate; also encodes minor aconitase or dehydratase activity; aconitase C; 2-methylcitrate dehydratase 325316 prpD 8175232 prpD Escherichia coli B str. REL606 2-methylcitrate dehydratase YP_003043515.1 323865 D 413997 CDS YP_003043516.1 254160408 8178340 325356..327242 1 NC_012967.1 catalyzes the formation of propionyl-CoA using propionate as a substrate; PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A; not expressed in Escherichia coli when grown on propionate/minimal media; ATP-dependent; propionyl-CoA synthetase 327242 prpE 8178340 prpE Escherichia coli B str. REL606 propionyl-CoA synthetase YP_003043516.1 325356 D 413997 CDS YP_003043517.1 254160409 8175233 327478..328737 1 NC_012967.1 similar to b0336; cytosine permease 328737 codB 8175233 codB Escherichia coli B str. REL606 cytosine permease YP_003043517.1 327478 D 413997 CDS YP_003043518.1 254160410 8175234 328727..330010 1 NC_012967.1 Catalyzes the deamination of cytosine to uracil and ammonia; cytosine deaminase 330010 codA 8175234 codA Escherichia coli B str. REL606 cytosine deaminase YP_003043518.1 328727 D 413997 CDS YP_003043519.1 254160411 8175235 complement(330347..331246) 1 NC_012967.1 controls the expression of the cynTSX operon involved in degrading and using cyanate as a sole nitrogen source; DNA-binding transcriptional regulator CynR 331246 cynR 8175235 cynR Escherichia coli B str. REL606 DNA-binding transcriptional regulator CynR YP_003043519.1 330347 R 413997 CDS YP_003043520.1 254160412 8175236 331355..332014 1 NC_012967.1 similar to b0339; carbonic anhydrase 332014 cynT 8175236 cynT Escherichia coli B str. REL606 carbonic anhydrase YP_003043520.1 331355 D 413997 CDS YP_003043521.1 254160413 8175237 332045..332515 1 NC_012967.1 catalyzes the reaction of cyanate and bicarbonate to produce ammonia and carbon dioxide; cyanate hydratase 332515 cynS 8175237 cynS Escherichia coli B str. REL606 cyanate hydratase YP_003043521.1 332045 D 413997 CDS YP_003043522.1 254160414 8178341 332548..333702 1 NC_012967.1 MFS transporter family member induced in the presence of cyanate as part of a 3 gene operon; not essential; putative cyanate transporter 333702 cynX 8178341 cynX Escherichia coli B str. REL606 putative cyanate transporter YP_003043522.1 332548 D 413997 CDS YP_003043523.1 254160415 8175238 complement(333805..334416) 1 NC_012967.1 transfers acetyl group from acetyl-CoA to the 6-hydroxyl of galactopyranosides; exact physiological role is unknown; galactoside O-acetyltransferase 334416 lacA 8175238 lacA Escherichia coli B str. REL606 galactoside O-acetyltransferase YP_003043523.1 333805 R 413997 CDS YP_003043524.1 254160416 8178891 complement(334482..335735) 1 NC_012967.1 lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments; galactoside permease 335735 lacY 8178891 lacY Escherichia coli B str. REL606 galactoside permease YP_003043524.1 334482 R 413997 CDS YP_003043525.1 254160417 8175239 complement(335787..338861) 1 NC_012967.1 forms a homotetramer; hydrolyzes lactose disaccharide to galactose and glucose; converts lactose to allolactose which is the natural inducer of the lac operon; beta-D-galactosidase 338861 lacZ 8175239 lacZ Escherichia coli B str. REL606 beta-D-galactosidase YP_003043525.1 335787 R 413997 CDS YP_003043526.1 254160418 8175240 complement(338984..340066) 1 NC_012967.1 transcriptional repressor of lac operon; forms a homotetramer as a dimer of dimers; binds specific sites in lac operon resulting in DNA looping between the operators; binds allolactose as inducer; lac repressor 340066 lacI 8175240 lacI Escherichia coli B str. REL606 lac repressor YP_003043526.1 338984 R 413997 CDS YP_003043527.1 254160419 8175241 complement(340143..341090) 1 NC_012967.1 activator of 3-phenylpropionic acid catabolism; DNA-binding transcriptional activator MhpR 341090 mhpR 8175241 mhpR Escherichia coli B str. REL606 DNA-binding transcriptional activator MhpR YP_003043527.1 340143 R 413997 CDS YP_003043528.1 254160420 8175242 341167..342831 1 NC_012967.1 catalyzes the formation of 3-(2,3-dihydroxyphenyl)propionate from 3-(3-hydroxyphenyl)propionate; 3-(3-hydroxyphenyl)propionate hydroxylase 342831 mhpA 8175242 mhpA Escherichia coli B str. REL606 3-(3-hydroxyphenyl)propionate hydroxylase YP_003043528.1 341167 D 413997 CDS YP_003043529.1 254160421 8175243 342833..343777 1 NC_012967.1 catalyzes the cleavage of 3-(2,3-dihydroxyphenyl) propionate into 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate; part of the 3-phenylpropionic acid degradation pathway; member of the protocatechuate 4,5-dioxygenase family; 3-(2,3-dihydroxyphenyl)propionate dioxygenase 343777 mhpB 8175243 mhpB Escherichia coli B str. REL606 3-(2,3-dihydroxyphenyl)propionate dioxygenase YP_003043529.1 342833 D 413997 CDS YP_003043530.1 254160422 8175244 343780..344661 1 NC_012967.1 similar to b0349; 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase 344661 mhpC 8175244 mhpC Escherichia coli B str. REL606 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase YP_003043530.1 343780 D 413997 CDS YP_003043531.1 254160423 8175245 344671..345480 1 NC_012967.1 catalyzes the formation of 2-keto-4-hydroxypentanoic acid from 2-hydroxypentadienoic acid; 2-keto-4-pentenoate hydratase 345480 mhpD 8175245 mhpD Escherichia coli B str. REL606 2-keto-4-pentenoate hydratase YP_003043531.1 344671 D 413997 CDS YP_003043532.1 254160424 8178342 345477..346427 1 NC_012967.1 catalyzes the formation of acetyl-CoA from acetalaldehyde; acetaldehyde dehydrogenase 346427 mhpF 8178342 mhpF Escherichia coli B str. REL606 acetaldehyde dehydrogenase YP_003043532.1 345477 D 413997 CDS YP_003043533.1 254160425 8175246 346424..347437 1 NC_012967.1 catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate; 4-hydroxy-2-ketovalerate aldolase 347437 mhpE 8175246 mhpE Escherichia coli B str. REL606 4-hydroxy-2-ketovalerate aldolase YP_003043533.1 346424 D 413997 CDS YP_003043534.1 254160426 8175247 347815..349026 1 NC_012967.1 similar to b0353; putative 3-hydroxyphenylpropionic transporter MhpT 349026 mhpT 8175247 mhpT Escherichia coli B str. REL606 putative 3-hydroxyphenylpropionic transporter MhpT YP_003043534.1 347815 D 413997 CDS YP_003043535.1 254160427 8175248 349128..349667 1 NC_012967.1 similar to b0354; nucleoprotein/polynucleotide-associated enzyme 349667 yaiL 8175248 yaiL Escherichia coli B str. REL606 nucleoprotein/polynucleotide-associated enzyme YP_003043535.1 349128 D 413997 CDS YP_003043536.1 254160428 8175249 complement(349893..350726) 1 NC_012967.1 similar to b0355; putative esterase 350726 frmB 8175249 frmB Escherichia coli B str. REL606 putative esterase YP_003043536.1 349893 R 413997 CDS YP_003043537.1 254160429 8175250 complement(350819..351928) 1 NC_012967.1 similar to b0356; alcohol dehydrogenase class III/glutathione-dependent formaldehyde dehydrogenase 351928 frmA 8175250 frmA Escherichia coli B str. REL606 alcohol dehydrogenase class III/glutathione-dependent formaldehyde dehydrogenase YP_003043537.1 350819 R 413997 CDS YP_003043538.1 254160430 8175251 complement(351963..352238) 1 NC_012967.1 formaldehyde-induced negative regulator of the frmRAB operon; regulator protein FrmR 352238 frmR 8175251 frmR Escherichia coli B str. REL606 regulator protein FrmR YP_003043538.1 351963 R 413997 CDS YP_003043539.1 254160431 8178343 complement(352424..353197) 1 NC_012967.1 similar to b0358; hypothetical protein 353197 yaiO 8178343 yaiO Escherichia coli B str. REL606 hypothetical protein YP_003043539.1 352424 R 413997 CDS YP_003043540.1 254160432 8175252 complement(353279..353782) 1 NC_012967.1 IS1 protein InsB 353782 insB-4 8175252 insB-4 Escherichia coli B str. REL606 IS1 protein InsB YP_003043540.1 353279 R 413997 CDS YP_003043541.1 254160433 8178892 complement(353701..353976) 1 NC_012967.1 IS1 protein InsA 353976 insA-4 8178892 insA-4 Escherichia coli B str. REL606 IS1 protein InsA YP_003043541.1 353701 R 413997 CDS YP_003043542.1 254160434 8178893 354140..355102 1 NC_012967.1 with TauB and TauC is responsible for taurine uptake.; taurine transporter substrate binding subunit 355102 tauA 8178893 tauA Escherichia coli B str. REL606 taurine transporter substrate binding subunit YP_003043542.1 354140 D 413997 CDS YP_003043543.1 254160435 8175253 355115..355882 1 NC_012967.1 Part of the ABC transporter complex tauABC involved in taurine import; taurine transporter ATP-binding subunit 355882 tauB 8175253 tauB Escherichia coli B str. REL606 taurine transporter ATP-binding subunit YP_003043543.1 355115 D 413997 CDS YP_003043544.1 254160436 8178894 355879..356706 1 NC_012967.1 similar to b0367; taurine transporter subunit 356706 tauC 8178894 tauC Escherichia coli B str. REL606 taurine transporter subunit YP_003043544.1 355879 D 413997 CDS YP_003043545.1 254160437 8175254 356703..357554 1 NC_012967.1 catalyzes the conversion of taurine (2-aminoethanesulfonate) to sulfite and aminoacetaldehyde concurrently with the conversion of alpha-ketoglutarate to succinate and carbon dioxide; non-heme iron oxidase; allows the use of taurine as an alternative sulfur source; forms homodimers; taurine dioxygenase 357554 tauD 8175254 tauD Escherichia coli B str. REL606 taurine dioxygenase YP_003043545.1 356703 D 413997 CDS YP_003043546.1 254160438 8175255 complement(357661..358635) 1 NC_012967.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 358635 hemB 8175255 hemB Escherichia coli B str. REL606 delta-aminolevulinic acid dehydratase YP_003043546.1 357661 R 413997 CDS YP_003043547.1 254160439 8175256 complement(358825..359022) 1 NC_012967.1 similar to b0370; hypothetical protein 359022 8175256 ECB_00320 Escherichia coli B str. REL606 hypothetical protein YP_003043547.1 358825 R 413997 CDS YP_003043548.1 254160440 8175257 359158..362064 1 NC_012967.1 similar to b0371-b0374; hypothetical protein 362064 yaiT 8175257 yaiT Escherichia coli B str. REL606 hypothetical protein YP_003043548.1 359158 D 413997 CDS YP_003043549.1 254160441 8175258 362107..362775 1 NC_012967.1 similar to b0375; putative DNA-binding transcriptional regulator 362775 yaiV 8175258 yaiV Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003043549.1 362107 D 413997 CDS YP_003043550.1 254160442 8175259 complement(362776..363933) 1 NC_012967.1 this protein has no known enzymatic function; beta-lactam binding protein AmpH 363933 ampH 8175259 ampH Escherichia coli B str. REL606 beta-lactam binding protein AmpH YP_003043550.1 362776 R 413997 CDS YP_003043551.1 254160443 8175260 364285..365505 1 NC_012967.1 in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope; transport protein 365505 sbmA 8175260 sbmA Escherichia coli B str. REL606 transport protein YP_003043551.1 364285 D 413997 CDS YP_003043552.1 254160444 8178344 365518..366612 1 NC_012967.1 similar to b0378; putative DNA-binding transcriptional regulator 366612 yaiW 8178344 yaiW Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003043552.1 365518 D 413997 CDS YP_003043553.1 254160445 8175261 complement(366671..366979) 1 NC_012967.1 similar to b0379; putative inner membrane protein 366979 yaiY 8175261 yaiY Escherichia coli B str. REL606 putative inner membrane protein YP_003043553.1 366671 R 413997 CDS YP_003043554.1 254160446 8175262 367239..367451 1 NC_012967.1 similar to b0380; putative inner membrane protein 367451 yaiZ 8175262 yaiZ Escherichia coli B str. REL606 putative inner membrane protein YP_003043554.1 367239 D 413997 CDS YP_003043555.1 254160447 8175263 complement(367475..368569) 1 NC_012967.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 368569 ddl 8175263 ddl Escherichia coli B str. REL606 D-alanyl-alanine synthetase A YP_003043555.1 367475 R 413997 CDS YP_003043556.1 254160448 8175264 369032..369292 1 NC_012967.1 similar to b0382; hypothetical protein 369292 yaiB 8175264 yaiB Escherichia coli B str. REL606 hypothetical protein YP_003043556.1 369032 D 413997 CDS YP_003043557.1 254160449 8175265 369393..370808 1 NC_012967.1 similar to b0383; alkaline phosphatase 370808 phoA 8175265 phoA Escherichia coli B str. REL606 alkaline phosphatase YP_003043557.1 369393 D 413997 CDS YP_003043558.1 254160450 8175266 370927..371247 1 NC_012967.1 similar to b0384; hypothetical protein 371247 psiF 8175266 psiF Escherichia coli B str. REL606 hypothetical protein YP_003043558.1 370927 D 413997 CDS YP_003043559.1 254160451 8178345 371349..372464 1 NC_012967.1 catalyzes the conversion of 2 GTP into c-di-GMP; adrA overexpression induces cellulose biosynthesis, cell adherence to abiotic surfaces and swimming and swarming motility; AdrA acts post-transcriptionally on the bcsABZC operon activating cellulose biosynthesis; diguanylate cyclase AdrA 372464 adrA 8178345 adrA Escherichia coli B str. REL606 diguanylate cyclase AdrA YP_003043559.1 371349 D 413997 CDS YP_003043560.1 254160452 8175267 complement(372481..373290) 1 NC_012967.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase 373290 proC 8175267 proC Escherichia coli B str. REL606 pyrroline-5-carboxylate reductase YP_003043560.1 372481 R 413997 CDS YP_003043561.1 254160453 8175268 373410..373868 1 NC_012967.1 similar to b0387; hypothetical protein 373868 yaiI 8175268 yaiI Escherichia coli B str. REL606 hypothetical protein YP_003043561.1 373410 D 413997 CDS YP_003043562.1 254160454 8175269 374051..374575 1 NC_012967.1 type II enzyme similar to type I but differentially regulated and with a lower Km; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase II 374575 aroL 8175269 aroL Escherichia coli B str. REL606 shikimate kinase II YP_003043562.1 374051 D 413997 CDS YP_003043563.1 254160455 8178346 374625..374816 1 NC_012967.1 similar to b0389; hypothetical protein 374816 yaiA 8178346 yaiA Escherichia coli B str. REL606 hypothetical protein YP_003043563.1 374625 D 413997 CDS YP_003043564.1 254160456 8175270 375074..375751 1 NC_012967.1 similar to b0390; hypothetical protein 375751 aroM 8175270 aroM Escherichia coli B str. REL606 hypothetical protein YP_003043564.1 375074 D 413997 CDS YP_003043565.1 254160457 8178895 375823..376107 1 NC_012967.1 similar to b0391; hypothetical protein 376107 yaiE 8178895 yaiE Escherichia coli B str. REL606 hypothetical protein YP_003043565.1 375823 D 413997 CDS YP_003043566.1 254160458 8178896 376315..376596 1 NC_012967.1 similar to b0392; hypothetical protein 376596 ykiA 8178896 ykiA Escherichia coli B str. REL606 hypothetical protein YP_003043566.1 376315 D 413997 CDS YP_003043567.1 254160459 8175271 complement(376764..377267) 1 NC_012967.1 IS1 protein InsB 377267 insB-5 8175271 insB-5 Escherichia coli B str. REL606 IS1 protein InsB YP_003043567.1 376764 R 413997 CDS YP_003043568.1 254160460 8175272 complement(377186..377461) 1 NC_012967.1 IS1 protein InsA 377461 insA-5 8175272 insA-5 Escherichia coli B str. REL606 IS1 protein InsA YP_003043568.1 377186 R 413997 CDS YP_003043569.1 254160461 8175273 complement(377531..378442) 1 NC_012967.1 Required for efficient pilin antigenic variation; recombination associated protein 378442 rdgC 8175273 rdgC Escherichia coli B str. REL606 recombination associated protein YP_003043569.1 377531 R 413997 CDS YP_003043570.1 254160462 8175274 378567..379475 1 NC_012967.1 catalyzes phosphorylation of fructose; cytosolic enzyme; fructokinase 379475 yajF 8175274 yajF Escherichia coli B str. REL606 fructokinase YP_003043570.1 378567 D 413997 CDS YP_003043571.1 254160463 8175275 complement(379720..380904) 1 NC_012967.1 member of the major facilitator superfamily (MFS) of transporters; unknown function; may be associated with transport or processing of arabinose polymers; MFS transport protein AraJ 380904 araJ 8175275 araJ Escherichia coli B str. REL606 MFS transport protein AraJ YP_003043571.1 379720 R 413997 CDS YP_003043572.1 254160464 8175276 complement(381030..384176) 1 NC_012967.1 with SbcD cleaves DNA hairpin structures; also has 5' single-strand endonuclease activity; exonuclease subunit SbcC 384176 sbcC 8175276 sbcC Escherichia coli B str. REL606 exonuclease subunit SbcC YP_003043572.1 381030 R 413997 CDS YP_003043573.1 254160465 8178347 complement(384173..385375) 1 NC_012967.1 with SbcC cleaves DNA hairpin structure, also has 5' single-strand endonuclease activity; exonuclease subunit SbcD 385375 sbcD 8178347 sbcD Escherichia coli B str. REL606 exonuclease subunit SbcD YP_003043573.1 384173 R 413997 CDS YP_003043574.1 254160466 8175277 385565..386254 1 NC_012967.1 two component response regulator for the phosphate regulon; PhoR phosphorylates PhoB; transcriptional regulator PhoB 386254 phoB 8175277 phoB Escherichia coli B str. REL606 transcriptional regulator PhoB YP_003043574.1 385565 D 413997 CDS YP_003043575.1 254160467 8175278 386312..387607 1 NC_012967.1 membrane-associated histidine protein kinase that phosphorylates phoB in response to environmental signals as part of the two-component phosphate regulatory system phoR/phoB; phosphate regulon sensor protein 387607 phoR 8175278 phoR Escherichia coli B str. REL606 phosphate regulon sensor protein YP_003043575.1 386312 D 413997 CDS YP_003043576.1 254160468 8178348 388014..389333 1 NC_012967.1 similar to b0401; putative branched chain amino acid transporter (LIV-II) 389333 brnQ 8178348 brnQ Escherichia coli B str. REL606 putative branched chain amino acid transporter (LIV-II) YP_003043576.1 388014 D 413997 CDS YP_003043577.1 254160469 8175279 389409..390782 1 NC_012967.1 cryptic permease that may be involved in the transport of proline across the inner membrane; in Salmonella typhimurium, the proY gene is silent unless overexpressed on a multicopy plasmid or activated by a proZ mutation; putative proline-specific permease 390782 proY 8175279 proY Escherichia coli B str. REL606 putative proline-specific permease YP_003043577.1 389409 D 413997 CDS YP_003043578.1 254160470 8175280 390938..392755 1 NC_012967.1 similar to b0403; maltodextrin glucosidase 392755 malZ 8175280 malZ Escherichia coli B str. REL606 maltodextrin glucosidase YP_003043578.1 390938 D 413997 CDS YP_003043579.1 254160471 8175282 393434..394504 1 NC_012967.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine:tRNA ribosyltransferase-isomerase 394504 queA 8175282 queA Escherichia coli B str. REL606 S-adenosylmethionine:tRNA ribosyltransferase-isomerase YP_003043579.1 393434 D 413997 CDS YP_003043580.1 254160472 8175283 394560..395687 1 NC_012967.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 395687 tgt 8175283 tgt Escherichia coli B str. REL606 queuine tRNA-ribosyltransferase YP_003043580.1 394560 D 413997 CDS YP_003043581.1 254160473 8175284 395710..396042 1 NC_012967.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 396042 yajC 8175284 yajC Escherichia coli B str. REL606 preprotein translocase subunit YajC YP_003043581.1 395710 D 413997 CDS YP_003043582.1 254160474 8178349 396070..397917 1 NC_012967.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 397917 secD 8178349 secD Escherichia coli B str. REL606 preprotein translocase subunit SecD YP_003043582.1 396070 D 413997 CDS YP_003043583.1 254160475 8175285 397928..398899 1 NC_012967.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 398899 secF 8175285 secF Escherichia coli B str. REL606 preprotein translocase subunit SecF YP_003043583.1 397928 D 413997 CDS YP_003043584.1 254160476 8178897 399027..399374 1 NC_012967.1 similar to b0410; hypothetical protein 399374 yajD 8178897 yajD Escherichia coli B str. REL606 hypothetical protein YP_003043584.1 399027 D 413997 CDS YP_003043585.1 254160477 8178898 complement(399662..400435) 1 NC_012967.1 similar to b0411; nucleoside channel phage T6/colicin K receptor 400435 tsx 8178898 tsx Escherichia coli B str. REL606 nucleoside channel phage T6/colicin K receptor YP_003043585.1 399662 R 413997 CDS YP_003043586.1 254160478 8175286 complement(400734..401273) 1 NC_012967.1 similar to b0412; hypothetical protein 401273 yajI 8175286 yajI Escherichia coli B str. REL606 hypothetical protein YP_003043586.1 400734 R 413997 CDS YP_003043587.1 254160479 8178899 401424..401873 1 NC_012967.1 similar to b0413; transcriptional regulator NrdR 401873 nrdR 8178899 nrdR Escherichia coli B str. REL606 transcriptional regulator NrdR YP_003043587.1 401424 D 413997 CDS YP_003043588.1 254160480 8175287 401877..402980 1 NC_012967.1 riboflavin biosynthesis protein which catalyzes the deamination and reduction steps in the riboflavin biosynthesis pathway; catalyzes the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 5-amino-6-(5-phosphoribitylamino)uracil; bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase 402980 ribD 8175287 ribD Escherichia coli B str. REL606 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase YP_003043588.1 401877 D 413997 CDS YP_003043589.1 254160481 8175288 403069..403539 1 NC_012967.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 403539 ribH 8175288 ribH Escherichia coli B str. REL606 6,7-dimethyl-8-ribityllumazine synthase YP_003043589.1 403069 D 413997 CDS YP_003043590.1 254160482 8175289 403559..403978 1 NC_012967.1 Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 403978 nusB 8175289 nusB Escherichia coli B str. REL606 transcription antitermination protein NusB YP_003043590.1 403559 D 413997 CDS YP_003043591.1 254160483 8175290 404056..405033 1 NC_012967.1 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase 405033 thiL 8175290 thiL Escherichia coli B str. REL606 thiamine monophosphate kinase YP_003043591.1 404056 D 413997 CDS YP_003043592.1 254160484 8175291 405011..405529 1 NC_012967.1 hydrolyzes phosphatidylglycerophosphate to produce phosphatidylglycerol and phosphate; phosphatidylglycerophosphatase A 405529 pgpA 8175291 pgpA Escherichia coli B str. REL606 phosphatidylglycerophosphatase A YP_003043592.1 405011 D 413997 CDS YP_003043593.1 254160485 8175292 complement(405583..406557) 1 NC_012967.1 similar to b0419; putative oxidoreductase 406557 yajO 8175292 yajO Escherichia coli B str. REL606 putative oxidoreductase YP_003043593.1 405583 R 413997 CDS YP_003043594.1 254160486 8175293 complement(406737..408599) 1 NC_012967.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 408599 dxs 8175293 dxs Escherichia coli B str. REL606 1-deoxy-D-xylulose-5-phosphate synthase YP_003043594.1 406737 R 413997 CDS YP_003043595.1 254160487 8175294 complement(408624..409523) 1 NC_012967.1 similar to b0421; geranyltranstransferase 409523 ispA 8175294 ispA Escherichia coli B str. REL606 geranyltranstransferase YP_003043595.1 408624 R 413997 CDS YP_003043596.1 254160488 8175295 complement(409523..409765) 1 NC_012967.1 catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 409765 xseB 8175295 xseB Escherichia coli B str. REL606 exodeoxyribonuclease VII small subunit YP_003043596.1 409523 R 413997 CDS YP_003043597.1 254160489 8175296 409971..411419 1 NC_012967.1 Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 411419 thiI 8175296 thiI Escherichia coli B str. REL606 thiamine biosynthesis protein ThiI YP_003043597.1 409971 D 413997 CDS YP_003043598.1 254160490 8178350 complement(411473..412063) 1 NC_012967.1 similar to b0424; DJ-1 family protein 412063 thiJ 8178350 thiJ Escherichia coli B str. REL606 DJ-1 family protein YP_003043598.1 411473 R 413997 CDS YP_003043599.1 254160491 8175297 complement(412026..412937) 1 NC_012967.1 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis; 2-dehydropantoate 2-reductase 412937 apbA 8175297 apbA Escherichia coli B str. REL606 2-dehydropantoate 2-reductase YP_003043599.1 412026 R 413997 CDS YP_003043600.1 254160492 8175298 413105..413596 1 NC_012967.1 putative nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription; putative nucleotide-binding protein 413596 yajQ 8175298 yajQ Escherichia coli B str. REL606 putative nucleotide-binding protein YP_003043600.1 413105 D 413997 CDS YP_003043601.1 254160493 8178900 complement(413724..415088) 1 NC_012967.1 similar to b0427; putative transporter 415088 yajR 8178900 yajR Escherichia coli B str. REL606 putative transporter YP_003043601.1 413724 R 413997 CDS YP_003043602.1 254160494 8178901 415505..416440 1 NC_012967.1 hypothetical protein 416440 8178901 ECB_00376 Escherichia coli B str. REL606 hypothetical protein YP_003043602.1 415505 D 413997 CDS YP_003043603.1 254160495 8175299 complement(416496..417038) 1 NC_012967.1 putative acetyltransferase 417038 8175299 ECB_00377 Escherichia coli B str. REL606 putative acetyltransferase YP_003043603.1 416496 R 413997 CDS YP_003043604.1 254160496 8175300 complement(417022..417399) 1 NC_012967.1 hypothetical protein 417399 8175300 ECB_00378 Escherichia coli B str. REL606 hypothetical protein YP_003043604.1 417022 R 413997 CDS YP_003043605.1 254160497 8175301 complement(417518..418408) 1 NC_012967.1 converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase 418408 cyoE 8175301 cyoE Escherichia coli B str. REL606 protoheme IX farnesyltransferase YP_003043605.1 417518 R 413997 CDS YP_003043606.1 254160498 8175302 complement(418420..418749) 1 NC_012967.1 similar to b0429; cytochrome o ubiquinol oxidase subunit IV 418749 cyoD 8175302 cyoD Escherichia coli B str. REL606 cytochrome o ubiquinol oxidase subunit IV YP_003043606.1 418420 R 413997 CDS YP_003043607.1 254160499 8178902 complement(418749..419363) 1 NC_012967.1 similar to b0430; cytochrome o ubiquinol oxidase subunit III 419363 cyoC 8178902 cyoC Escherichia coli B str. REL606 cytochrome o ubiquinol oxidase subunit III YP_003043607.1 418749 R 413997 CDS YP_003043608.1 254160500 8175303 complement(419353..421344) 1 NC_012967.1 similar to b0431; cytochrome o ubiquinol oxidase subunit I 421344 cyoB 8175303 cyoB Escherichia coli B str. REL606 cytochrome o ubiquinol oxidase subunit I YP_003043608.1 419353 R 413997 CDS YP_003043609.1 254160501 8175304 complement(421366..422313) 1 NC_012967.1 similar to b0432; cytochrome o ubiquinol oxidase subunit II 422313 cyoA 8175304 cyoA Escherichia coli B str. REL606 cytochrome o ubiquinol oxidase subunit II YP_003043609.1 421366 R 413997 CDS YP_003043610.1 254160502 8175305 complement(422775..424250) 1 NC_012967.1 in Escherichia coli this protein is a permease involved in peptidoglycan recycling; member of major facilitator superfamily; MFS; inner membrane protein; muropeptide transporter 424250 ampG 8175305 ampG Escherichia coli B str. REL606 muropeptide transporter YP_003043610.1 422775 R 413997 CDS YP_003043611.1 254160503 8175306 complement(424294..424872) 1 NC_012967.1 similar to b0434; hypothetical protein 424872 yajG 8175306 yajG Escherichia coli B str. REL606 hypothetical protein YP_003043611.1 424294 R 413997 CDS YP_003043612.1 254160504 8175307 425177..425494 1 NC_012967.1 positive transcriptional regulator of morphogenetic pathway; controlling several genes involved in oxidative stress, acid stress, heat shock, osmotic shock, and carbon-starvation stress; transcriptional regulator BolA 425494 bolA 8175307 bolA Escherichia coli B str. REL606 transcriptional regulator BolA YP_003043612.1 425177 D 413997 CDS YP_003043613.1 254160505 8175308 425838..427136 1 NC_012967.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 427136 tig 8175308 tig Escherichia coli B str. REL606 trigger factor YP_003043613.1 425838 D 413997 CDS YP_003043614.1 254160506 8175309 427382..428005 1 NC_012967.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 428005 clpP 8175309 clpP Escherichia coli B str. REL606 ATP-dependent Clp protease proteolytic subunit YP_003043614.1 427382 D 413997 CDS YP_003043615.1 254160507 8178351 428131..429405 1 NC_012967.1 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 429405 clpX 8178351 clpX Escherichia coli B str. REL606 ATP-dependent protease ATP-binding subunit ClpX YP_003043615.1 428131 D 413997 CDS YP_003043616.1 254160508 8178352 complement(429675..430787) 1 NC_012967.1 putative transposase insL for insertion sequence IS186 430787 insL-2 8178352 insL-2 Escherichia coli B str. REL606 putative transposase insL for insertion sequence IS186 YP_003043616.1 429675 R 413997 CDS YP_003043617.1 254160509 8175310 430943..433297 1 NC_012967.1 similar to b0439; DNA-binding ATP-dependent protease La 433297 lon 8175310 lon Escherichia coli B str. REL606 DNA-binding ATP-dependent protease La YP_003043617.1 430943 D 413997 CDS YP_003043618.1 254160510 8175311 433506..433778 1 NC_012967.1 histone-like DNA-binding protein; transcriptional regulator HU subunit beta 433778 hupB 8175311 hupB Escherichia coli B str. REL606 transcriptional regulator HU subunit beta YP_003043618.1 433506 D 413997 CDS YP_003043619.1 254160511 8175312 433970..435841 1 NC_012967.1 similar to b0441; peptidyl-prolyl cis-trans isomerase (rotamase D) 435841 ppiD 8175312 ppiD Escherichia coli B str. REL606 peptidyl-prolyl cis-trans isomerase (rotamase D) YP_003043619.1 433970 D 413997 CDS YP_003043620.1 254160512 8175313 435992..436363 1 NC_012967.1 similar to b0442; hypothetical protein 436363 ybaV 8175313 ybaV Escherichia coli B str. REL606 hypothetical protein YP_003043620.1 435992 D 413997 CDS YP_003043621.1 254160513 8178903 436469..436867 1 NC_012967.1 similar to b0443; hypothetical protein 436867 ybaW 8178903 ybaW Escherichia coli B str. REL606 hypothetical protein YP_003043621.1 436469 D 413997 CDS YP_003043622.1 254160514 8175314 complement(436919..437614) 1 NC_012967.1 YbaX; catalyzes the transformation of GTP to 7-cyano-7-deazaguanine (preQ0), as one of the early reactions of quenosine biosynthesis; quenosine is a modified nucleoside that occurs at the wobble position of GUN anticodons in tRNAs for Asn, Asp, Tyr, and His; queuosine biosynthesis protein QueC 437614 ybaX 8175314 ybaX Escherichia coli B str. REL606 queuosine biosynthesis protein QueC YP_003043622.1 436919 R 413997 CDS YP_003043623.1 254160515 8175315 complement(437679..439379) 1 NC_012967.1 similar to b0445; putative transporter subunit periplasmic-binding component of ABC superfamily 439379 ybaE 8175315 ybaE Escherichia coli B str. REL606 putative transporter subunit periplasmic-binding component of ABC superfamily YP_003043623.1 437679 R 413997 CDS YP_003043624.1 254160516 8175316 439479..440297 1 NC_012967.1 similar to b0446; thiamin pyrimidine pyrophosphate hydrolase 440297 cof 8175316 cof Escherichia coli B str. REL606 thiamin pyrimidine pyrophosphate hydrolase YP_003043624.1 439479 D 413997 CDS YP_003043625.1 254160517 8178904 440450..440908 1 NC_012967.1 similar to b0447; putative DNA-binding transcriptional regulator 440908 ybaO 8178904 ybaO Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003043625.1 440450 D 413997 CDS YP_003043626.1 254160518 8178905 440938..442710 1 NC_012967.1 similar to b0448; putative multidrug transporter membrane\ATP-binding proteins 442710 mdlA 8178905 mdlA Escherichia coli B str. REL606 putative multidrug transporter membrane\ATP-binding proteins YP_003043626.1 440938 D 413997 CDS YP_003043627.1 254160519 8175317 442703..444484 1 NC_012967.1 similar to b0449; putative multidrug transporter membrane\ATP-binding proteins 444484 mdlB 8175317 mdlB Escherichia coli B str. REL606 putative multidrug transporter membrane\ATP-binding proteins YP_003043627.1 442703 D 413997 CDS YP_003043628.1 254160520 8175318 444665..445003 1 NC_012967.1 indirectly regulates nitrogen metabolism; at high nitrogen levels P-II 2 prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II 2 is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; functionally it is equivalent to protein P-II (GlnB), but itsexpression is driven by the presence of uridylyltransferase, nitrogen regulator I, and the absence of ammonia.; nitrogen regulatory protein P-II 2 445003 glnK 8175318 glnK Escherichia coli B str. REL606 nitrogen regulatory protein P-II 2 YP_003043628.1 444665 D 413997 CDS YP_003043629.1 254160521 8175319 445033..446319 1 NC_012967.1 similar to b0451; ammonium transporter 446319 amtB 8175319 amtB Escherichia coli B str. REL606 ammonium transporter YP_003043629.1 445033 D 413997 CDS YP_003043630.1 254160522 8175320 complement(446368..447228) 1 NC_012967.1 similar to b0452; acyl-CoA thioesterase II 447228 tesB 8175320 tesB Escherichia coli B str. REL606 acyl-CoA thioesterase II YP_003043630.1 446368 R 413997 CDS YP_003043631.1 254160523 8175321 447446..448018 1 NC_012967.1 similar to b0453; putative outer membrane lipoprotein 448018 ybaY 8175321 ybaY Escherichia coli B str. REL606 putative outer membrane lipoprotein YP_003043631.1 447446 D 413997 CDS YP_003043632.1 254160524 8175322 complement(448049..448438) 1 NC_012967.1 similar to b0454; putative methyltransferase 448438 ybaZ 8175322 ybaZ Escherichia coli B str. REL606 putative methyltransferase YP_003043632.1 448049 R 413997 CDS YP_003043633.1 254160525 8175323 448739..449092 1 NC_012967.1 similar to b0456; hypothetical protein 449092 ybaA 8175323 ybaA Escherichia coli B str. REL606 hypothetical protein YP_003043633.1 448739 D 413997 CDS YP_003043634.1 254160526 8178353 complement(449134..450684) 1 NC_012967.1 similar to b0457; inner membrane protein 450684 ylaB 8178353 ylaB Escherichia coli B str. REL606 inner membrane protein YP_003043634.1 449134 R 413997 CDS YP_003043635.1 254160527 8175324 complement(450848..451318) 1 NC_012967.1 similar to b0458; putative inner membrane protein 451318 ylaC 8175324 ylaC Escherichia coli B str. REL606 putative inner membrane protein YP_003043635.1 450848 R 413997 CDS YP_003043636.1 254160528 8175325 complement(451434..451985) 1 NC_012967.1 similar to b0459; maltose O-acetyltransferase 451985 maa 8175325 maa Escherichia coli B str. REL606 maltose O-acetyltransferase YP_003043636.1 451434 R 413997 CDS YP_003043637.1 254160529 8175326 complement(452157..452375) 1 NC_012967.1 with Hns involved in transcriptional regulation of hemolysin; non-specific DNA-binding protein which affects the production of multiple proteins; hemolysin expression-modulating protein 452375 hha 8175326 hha Escherichia coli B str. REL606 hemolysin expression-modulating protein YP_003043637.1 452157 R 413997 CDS YP_003043638.1 254160530 8175327 complement(452401..452775) 1 NC_012967.1 similar to b0461; hypothetical protein 452775 ybaJ 8175327 ybaJ Escherichia coli B str. REL606 hypothetical protein YP_003043638.1 452401 R 413997 CDS YP_003043639.1 254160531 8178354 complement(453321..456470) 1 NC_012967.1 similar to b0462; multidrug efflux system protein 456470 acrB 8178354 acrB Escherichia coli B str. REL606 multidrug efflux system protein YP_003043639.1 453321 R 413997 CDS YP_003043640.1 254160532 8178355 complement(456493..457686) 1 NC_012967.1 similar to b0463; multidrug efflux system 457686 acrA 8178355 acrA Escherichia coli B str. REL606 multidrug efflux system YP_003043640.1 456493 R 413997 CDS YP_003043641.1 254160533 8175328 457828..458475 1 NC_012967.1 regulates the acrAB operon which is involved in susceptibility to dephalothin and cephaloridine; DNA-binding transcriptional repressor AcrR 458475 acrR 8175328 acrR Escherichia coli B str. REL606 DNA-binding transcriptional repressor AcrR YP_003043641.1 457828 D 413997 CDS YP_003043642.1 254160534 8175329 458603..461965 1 NC_012967.1 small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS; potassium efflux protein KefA 461965 kefA 8175329 kefA Escherichia coli B str. REL606 potassium efflux protein KefA YP_003043642.1 458603 D 413997 CDS YP_003043643.1 254160535 8175330 complement(462177..462338) 1 NC_012967.1 similar to b0466; hypothetical protein 462338 ybaM 8175330 ybaM Escherichia coli B str. REL606 hypothetical protein YP_003043643.1 462177 R 413997 CDS YP_003043644.1 254160536 8175331 complement(462352..462879) 1 NC_012967.1 PriC; protein involved in DNA replication; part of the primosome, a protein complex required to restart stalled replication forks; binds the complex formed by PriA, PriB and DNA; PriC-dependent primosome requires a gap to restart DNA replication; stimulates Rep activity at stalled forks; primosomal replication protein N'' 462879 priC 8175331 priC Escherichia coli B str. REL606 primosomal replication protein N'' YP_003043644.1 462352 R 413997 CDS YP_003043645.1 254160537 8178906 462949..463326 1 NC_012967.1 similar to b0468; hypothetical protein 463326 ybaN 8178906 ybaN Escherichia coli B str. REL606 hypothetical protein YP_003043645.1 462949 D 413997 CDS YP_003043646.1 254160538 8178907 463479..464030 1 NC_012967.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 464030 apt 8178907 apt Escherichia coli B str. REL606 adenine phosphoribosyltransferase YP_003043646.1 463479 D 413997 CDS YP_003043647.1 254160539 8175332 464159..466090 1 NC_012967.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 466090 dnaX 8175332 dnaX Escherichia coli B str. REL606 DNA polymerase III subunits gamma and tau YP_003043647.1 464159 D 413997 CDS YP_003043648.1 254160540 8175333 466143..466472 1 NC_012967.1 similar to b0471; hypothetical protein 466472 ybaB 8175333 ybaB Escherichia coli B str. REL606 hypothetical protein YP_003043648.1 466143 D 413997 CDS YP_003043649.1 254160541 8175334 466472..467077 1 NC_012967.1 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 467077 recR 8175334 recR Escherichia coli B str. REL606 recombination protein RecR YP_003043649.1 466472 D 413997 CDS YP_003043650.1 254160542 8175335 467187..469061 1 NC_012967.1 molecular chaperone; heat shock protein 90 469061 htpG 8175335 htpG Escherichia coli B str. REL606 heat shock protein 90 YP_003043650.1 467187 D 413997 CDS YP_003043651.1 254160543 8175336 469242..469886 1 NC_012967.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 469886 adk 8175336 adk Escherichia coli B str. REL606 adenylate kinase YP_003043651.1 469242 D 413997 CDS YP_003043652.1 254160544 8175337 470122..471084 1 NC_012967.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 471084 hemH 8175337 hemH Escherichia coli B str. REL606 ferrochelatase YP_003043652.1 470122 D 413997 CDS YP_003043653.1 254160545 8175338 complement(471081..472040) 1 NC_012967.1 similar to b0476; acetyl esterase 472040 aes 8175338 aes Escherichia coli B str. REL606 acetyl esterase YP_003043653.1 471081 R 413997 CDS YP_003043654.1 254160546 8175339 472192..473496 1 NC_012967.1 similar to b0477; inosine/guanosine kinase 473496 gsk 8175339 gsk Escherichia coli B str. REL606 inosine/guanosine kinase YP_003043654.1 472192 D 413997 CDS YP_003043655.1 254160547 8178356 complement(473629..475305) 1 NC_012967.1 YbaL; member of the CPA-2 family of antiporters; uncharacterized protein; putative cation:proton antiport protein 475305 ybaL 8178356 ybaL Escherichia coli B str. REL606 putative cation:proton antiport protein YP_003043655.1 473629 R 413997 CDS YP_003043656.1 254160548 8178357 complement(475543..476763) 1 NC_012967.1 similar to b0479; putative fosmidomycin efflux system 476763 fsr 8178357 fsr Escherichia coli B str. REL606 putative fosmidomycin efflux system YP_003043656.1 475543 R 413997 CDS YP_003043657.1 254160549 8175340 476981..478633 1 NC_012967.1 catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides; bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor 478633 ushA 8175340 ushA Escherichia coli B str. REL606 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor YP_003043657.1 476981 D 413997 CDS YP_003043658.1 254160550 8175341 complement(478670..479149) 1 NC_012967.1 similar to b0481; hypothetical protein 479149 ybaK 8175341 ybaK Escherichia coli B str. REL606 hypothetical protein YP_003043658.1 478670 R 413997 CDS YP_003043659.1 254160551 8175342 complement(479353..480147) 1 NC_012967.1 similar to b0482; hypothetical protein 480147 ybaP 8175342 ybaP Escherichia coli B str. REL606 hypothetical protein YP_003043659.1 479353 R 413997 CDS YP_003043660.1 254160552 8175343 480285..480626 1 NC_012967.1 similar to b0483; putative DNA-binding transcriptional regulator 480626 ybaQ 8175343 ybaQ Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003043660.1 480285 D 413997 CDS YP_003043661.1 254160553 8178358 complement(481043..483547) 1 NC_012967.1 similar to b0484; copper exporting ATPase 483547 copA 8178358 copA Escherichia coli B str. REL606 copper exporting ATPase YP_003043661.1 481043 R 413997 CDS YP_003043662.1 254160554 8178908 483809..484741 1 NC_012967.1 catalyzes the formation of glutamate from glutamine; glutaminase 484741 ybaS 8178908 ybaS Escherichia coli B str. REL606 glutaminase YP_003043662.1 483809 D 413997 CDS YP_003043663.1 254160555 8175344 484744..486036 1 NC_012967.1 similar to b0486; putative transporter 486036 ybaT 8175344 ybaT Escherichia coli B str. REL606 putative transporter YP_003043663.1 484744 D 413997 CDS YP_003043664.1 254160556 8175345 486161..486568 1 NC_012967.1 DNA-binding transcriptional activator of copper-responsive regulon genes; DNA-binding transcriptional regulator CueR 486568 cueR 8175345 cueR Escherichia coli B str. REL606 DNA-binding transcriptional regulator CueR YP_003043664.1 486161 D 413997 CDS YP_003043665.1 254160557 8175346 complement(486569..487024) 1 NC_012967.1 similar to b0488; inner membrane protein 487024 ybbJ 8175346 ybbJ Escherichia coli B str. REL606 inner membrane protein YP_003043665.1 486569 R 413997 CDS YP_003043666.1 254160558 8175347 complement(487024..487941) 1 NC_012967.1 similar to b0489; putative protease, membrane anchored 487941 ybbK 8175347 ybbK Escherichia coli B str. REL606 putative protease, membrane anchored YP_003043666.1 487024 R 413997 CDS YP_003043667.1 254160559 8178909 488087..488764 1 NC_012967.1 similar to b0490; putative ABC transporter ATP-binding protein YbbL 488764 ybbL 8178909 ybbL Escherichia coli B str. REL606 putative ABC transporter ATP-binding protein YbbL YP_003043667.1 488087 D 413997 CDS YP_003043668.1 254160560 8178910 488751..489530 1 NC_012967.1 similar to b0491; putative inner membrane protein 489530 ybbM 8178910 ybbM Escherichia coli B str. REL606 putative inner membrane protein YP_003043668.1 488751 D 413997 CDS YP_003043669.1 254160561 8175348 complement(489593..490447) 1 NC_012967.1 similar to b0492; putative thioredoxin domain-containing protein 490447 ybbN 8175348 ybbN Escherichia coli B str. REL606 putative thioredoxin domain-containing protein YP_003043669.1 489593 R 413997 CDS YP_003043670.1 254160562 8175349 complement(490508..491317) 1 NC_012967.1 similar to b0493; short chain dehydrogenase 491317 ybbO 8175349 ybbO Escherichia coli B str. REL606 short chain dehydrogenase YP_003043670.1 490508 R 413997 CDS YP_003043671.1 254160563 8175350 complement(491307..491933) 1 NC_012967.1 similar to b0494; multifunctional acyl-CoA thioesterase I and protease I and lysophospholipase L1 491933 tesA 8175350 tesA Escherichia coli B str. REL606 multifunctional acyl-CoA thioesterase I and protease I and lysophospholipase L1 YP_003043671.1 491307 R 413997 CDS YP_003043672.1 254160564 8175351 491901..492587 1 NC_012967.1 similar to b0495; putative ABC transporter ATP-binding protein YbbA 492587 ybbA 8175351 ybbA Escherichia coli B str. REL606 putative ABC transporter ATP-binding protein YbbA YP_003043672.1 491901 D 413997 CDS YP_003043673.1 254160565 8175352 492584..494998 1 NC_012967.1 similar to b0496; putative inner membrane protein 494998 ybbP 8175352 ybbP Escherichia coli B str. REL606 putative inner membrane protein YP_003043673.1 492584 D 413997 CDS YP_003043674.1 254160566 8175353 495428..499708 1 NC_012967.1 similar to b0497; rhsD element protein 499708 rhsD 8175353 rhsD Escherichia coli B str. REL606 rhsD element protein YP_003043674.1 495428 D 413997 CDS YP_003043675.1 254160567 8175354 499748..500116 1 NC_012967.1 similar to b0498; hypothetical protein 500116 ybbC 8175354 ybbC Escherichia coli B str. REL606 hypothetical protein YP_003043675.1 499748 D 413997 CDS YP_003043676.1 254160568 8178359 500116..500826 1 NC_012967.1 similar to b0499; hypothetical protein 500826 ylbH 8178359 ylbH Escherichia coli B str. REL606 hypothetical protein YP_003043676.1 500116 D 413997 CDS YP_003043677.1 254160569 8175355 500807..501067 1 NC_012967.1 similar to b0500; hypothetical protein 501067 ybbD 8175355 ybbD Escherichia coli B str. REL606 hypothetical protein YP_003043677.1 500807 D 413997 CDS YP_003043678.1 254160570 8175356 complement(501811..502182) 1 NC_012967.1 similar to b0502; putative DNA-binding transcriptional regulator 502182 ylbG 8175356 ylbG Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003043678.1 501811 R 413997 CDS YP_003043679.1 254160571 8178360 complement(502298..503392) 1 NC_012967.1 catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA; tRNA 2-selenouridine synthase 503392 ybbB 8178360 ybbB Escherichia coli B str. REL606 tRNA 2-selenouridine synthase YP_003043679.1 502298 R 413997 CDS YP_003043680.1 254160572 8175357 complement(503461..504387) 1 NC_012967.1 activator of the allDC-ylbA operon involved in allantoin utilization; DNA-binding transcriptional activator AllS 504387 ybbS 8175357 ybbS Escherichia coli B str. REL606 DNA-binding transcriptional activator AllS YP_003043680.1 503461 R 413997 CDS YP_003043681.1 254160573 8175358 504617..505099 1 NC_012967.1 catalyzes the formation of glyoxylate from (S)-ureidoglycolate; ureidoglycolate hydrolase 505099 allA 8175358 allA Escherichia coli B str. REL606 ureidoglycolate hydrolase YP_003043681.1 504617 D 413997 CDS YP_003043682.1 254160574 8178911 505177..505992 1 NC_012967.1 regulates operons involved in the utilization of allantoin; DNA-binding transcriptional repressor AllR 505992 allR 8178911 allR Escherichia coli B str. REL606 DNA-binding transcriptional repressor AllR YP_003043682.1 505177 D 413997 CDS YP_003043683.1 254160575 8175359 506082..507863 1 NC_012967.1 catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate; glyoxylate carboligase 507863 gcl 8175359 gcl Escherichia coli B str. REL606 glyoxylate carboligase YP_003043683.1 506082 D 413997 CDS YP_003043684.1 254160576 8175360 507876..508652 1 NC_012967.1 similar to b0508; hydroxypyruvate isomerase 508652 hyi 8175360 hyi Escherichia coli B str. REL606 hydroxypyruvate isomerase YP_003043684.1 507876 D 413997 CDS YP_003043685.1 254160577 8175361 508752..509630 1 NC_012967.1 similar to b0509; tartronate semialdehyde reductase, NADH-dependent 509630 glxR 8175361 glxR Escherichia coli B str. REL606 tartronate semialdehyde reductase, NADH-dependent YP_003043685.1 508752 D 413997 CDS YP_003043686.1 254160578 8175362 509662..509940 1 NC_012967.1 similar to b0510; hypothetical protein 509940 ybbV 8175362 ybbV Escherichia coli B str. REL606 hypothetical protein YP_003043686.1 509662 D 413997 CDS YP_003043687.1 254160579 8178912 509799..511253 1 NC_012967.1 similar to b0511; allantoin permease 511253 allP 8178912 allP Escherichia coli B str. REL606 allantoin permease YP_003043687.1 509799 D 413997 CDS YP_003043688.1 254160580 8175363 511313..512674 1 NC_012967.1 Plays a crucial role on both purine and pyrimidine metabolism; allantoinase 512674 allB 8175363 allB Escherichia coli B str. REL606 allantoinase YP_003043688.1 511313 D 413997 CDS YP_003043689.1 254160581 8175364 512731..514032 1 NC_012967.1 similar to b0513; putative purine permease YbbY 514032 ybbY 8175364 ybbY Escherichia coli B str. REL606 putative purine permease YbbY YP_003043689.1 512731 D 413997 CDS YP_003043690.1 254160582 8175365 514054..515199 1 NC_012967.1 similar to b0514; glycerate kinase II 515199 glxK 8175365 glxK Escherichia coli B str. REL606 glycerate kinase II YP_003043690.1 514054 D 413997 CDS YP_003043691.1 254160583 8175366 complement(515427..516212) 1 NC_012967.1 similar to b0515; hypothetical protein 516212 ylbA 8175366 ylbA Escherichia coli B str. REL606 hypothetical protein YP_003043691.1 515427 R 413997 CDS YP_003043692.1 254160584 8175367 complement(516223..517458) 1 NC_012967.1 allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide; allantoate amidohydrolase 517458 allC 8175367 allC Escherichia coli B str. REL606 allantoate amidohydrolase YP_003043692.1 516223 R 413997 CDS YP_003043693.1 254160585 8175368 complement(517480..518529) 1 NC_012967.1 similar to b0517; ureidoglycolate dehydrogenase 518529 allD 8175368 allD Escherichia coli B str. REL606 ureidoglycolate dehydrogenase YP_003043693.1 517480 R 413997 CDS YP_003043694.1 254160586 8178913 518846..520513 1 NC_012967.1 multicopy suppressor of dominant negative ftsH mutations; membrane protein FdrA 520513 fdrA 8178913 fdrA Escherichia coli B str. REL606 membrane protein FdrA YP_003043694.1 518846 D 413997 CDS YP_003043695.1 254160587 8175369 520523..521782 1 NC_012967.1 similar to b4507-b0519(b4582); pseudo in K-12 MG1655 (interrupted by frameshift); hypothetical protein 521782 ylbE 8175369 ylbE Escherichia coli B str. REL606 hypothetical protein YP_003043695.1 520523 D 413997 CDS YP_003043696.1 254160588 8175370 521889..522608 1 NC_012967.1 similar to b0520; hypothetical protein 522608 ylbF 8175370 ylbF Escherichia coli B str. REL606 hypothetical protein YP_003043696.1 521889 D 413997 CDS YP_003043697.1 254160589 8178914 522605..523498 1 NC_012967.1 similar to b0521; carbamate kinase 523498 arcC 8178914 arcC Escherichia coli B str. REL606 carbamate kinase YP_003043697.1 522605 D 413997 CDS YP_003043698.1 254160590 8175371 complement(523635..524702) 1 NC_012967.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 524702 purK 8175371 purK Escherichia coli B str. REL606 phosphoribosylaminoimidazole carboxylase ATPase subunit YP_003043698.1 523635 R 413997 CDS YP_003043699.1 254160591 8178915 complement(524699..525208) 1 NC_012967.1 similar to b0523; phosphoribosylaminoimidazole carboxylase catalytic subunit 525208 purE 8178915 purE Escherichia coli B str. REL606 phosphoribosylaminoimidazole carboxylase catalytic subunit YP_003043699.1 524699 R 413997 CDS YP_003043700.1 254160592 8175372 complement(525326..526048) 1 NC_012967.1 catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine; UDP-2,3-diacylglucosamine hydrolase 526048 ybbF 8175372 ybbF Escherichia coli B str. REL606 UDP-2,3-diacylglucosamine hydrolase YP_003043700.1 525326 R 413997 CDS YP_003043701.1 254160593 8175373 complement(526051..526545) 1 NC_012967.1 similar to b0525; peptidyl-prolyl cis-trans isomerase B (rotamase B) 526545 ppiB 8175373 ppiB Escherichia coli B str. REL606 peptidyl-prolyl cis-trans isomerase B (rotamase B) YP_003043701.1 526051 R 413997 CDS YP_003043702.1 254160594 8175374 526719..528104 1 NC_012967.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 528104 cysS 8175374 cysS Escherichia coli B str. REL606 cysteinyl-tRNA synthetase YP_003043702.1 526719 D 413997 CDS YP_003043703.1 254160595 8175375 complement(528140..528661) 1 NC_012967.1 similar to b0527; inner membrane protein 528661 ybcI 8175375 ybcI Escherichia coli B str. REL606 inner membrane protein YP_003043703.1 528140 R 413997 CDS YP_003043704.1 254160596 8178361 complement(528769..528981) 1 NC_012967.1 similar to b0528; hypothetical protein 528981 ybcJ 8178361 ybcJ Escherichia coli B str. REL606 hypothetical protein YP_003043704.1 528769 R 413997 CDS YP_003043705.1 254160597 8175376 complement(528983..529849) 1 NC_012967.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 529849 folD 8175376 folD Escherichia coli B str. REL606 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase YP_003043705.1 528983 R 413997 CDS YP_003043706.1 254160598 8175377 530320..530862 1 NC_012967.1 similar to b0530; putative fimbrial-like adhesin protein 530862 sfmA 8175377 sfmA Escherichia coli B str. REL606 putative fimbrial-like adhesin protein YP_003043706.1 530320 D 413997 CDS YP_003043707.1 254160599 8178916 531082..531774 1 NC_012967.1 similar to b0531; pilin chaperone 531774 sfmC 8178916 sfmC Escherichia coli B str. REL606 pilin chaperone YP_003043707.1 531082 D 413997 CDS YP_003043708.1 254160600 8175378 531805..534414 1 NC_012967.1 similar to b0532; putative outer membrane export usher protein 534414 sfmD 8175378 sfmD Escherichia coli B str. REL606 putative outer membrane export usher protein YP_003043708.1 531805 D 413997 CDS YP_003043709.1 254160601 8175379 534456..535433 1 NC_012967.1 similar to b0533; putative fimbrial-like adhesin protein 535433 sfmH 8175379 sfmH Escherichia coli B str. REL606 putative fimbrial-like adhesin protein YP_003043709.1 534456 D 413997 CDS YP_003043710.1 254160602 8175380 535444..535959 1 NC_012967.1 similar to b0534; putative fimbrial protein 535959 sfmF 8175380 sfmF Escherichia coli B str. REL606 putative fimbrial protein YP_003043710.1 535444 D 413997 CDS YP_003043711.1 254160603 8175381 complement(535962..536594) 1 NC_012967.1 activates the production of the major fimbrae protein FimA; transcriptional regulator FimZ 536594 fimZ 8175381 fimZ Escherichia coli B str. REL606 transcriptional regulator FimZ YP_003043711.1 535962 R 413997 CDS YP_003043712.1 254160604 8175382 complement(536929..538092) 1 NC_012967.1 similar to b0537; putative integrase 538092 intD 8175382 intD Escherichia coli B str. REL606 putative integrase YP_003043712.1 536929 R 413997 CDS YP_003043713.1 254160605 8178362 complement(537948..538349) 1 NC_012967.1 Excisionase 538349 8178362 ECB_00487 Escherichia coli B str. REL606 Excisionase YP_003043713.1 537948 R 413997 CDS YP_003043714.1 254160606 8175383 complement(538617..538835) 1 NC_012967.1 hypothetical protein 538835 8175383 ECB_00488 Escherichia coli B str. REL606 hypothetical protein YP_003043714.1 538617 R 413997 CDS YP_003043715.1 254160607 8175384 complement(538934..539248) 1 NC_012967.1 hypothetical protein 539248 8175384 ECB_00489 Escherichia coli B str. REL606 hypothetical protein YP_003043715.1 538934 R 413997 CDS YP_003043716.1 254160608 8178363 complement(539226..539591) 1 NC_012967.1 putative DNA N-6-adenine-methyltransferase of bacteriophage 539591 8178363 ECB_00490 Escherichia coli B str. REL606 putative DNA N-6-adenine-methyltransferase of bacteriophage YP_003043716.1 539226 R 413997 CDS YP_003043717.1 254160609 8175386 539952..540137 1 NC_012967.1 similar to b0542; hypothetical protein 540137 renD 8175386 renD Escherichia coli B str. REL606 hypothetical protein YP_003043717.1 539952 D 413997 CDS YP_003043718.1 254160610 8175387 540205..540537 1 NC_012967.1 member of the small MDR (multidrug resistance) family of transporters; in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin; proton-dependent secondary transporter which exchanges protons for compound translocation; multidrug efflux protein 540537 emrE 8175387 emrE Escherichia coli B str. REL606 multidrug efflux protein YP_003043718.1 540205 D 413997 CDS YP_003043719.1 254160611 8175388 540792..542318 1 NC_012967.1 similar to b0544; putative recombinase 542318 ybcK 8175388 ybcK Escherichia coli B str. REL606 putative recombinase YP_003043719.1 540792 D 413997 CDS YP_003043720.1 254160612 8175389 542783..543334 1 NC_012967.1 DLP12 prophage; similar to PEBP/RK1P protein family in eukaryotes that inhibits MEK phosphorylation by Raf-1; crystal structure suggests similar properties but exact function is unknown; putative kinase inhibitor 543334 ybcL 8175389 ybcL Escherichia coli B str. REL606 putative kinase inhibitor YP_003043720.1 542783 D 413997 CDS YP_003043721.1 254160613 8175390 543344..544141 1 NC_012967.1 similar to b0546; putative DNA-binding transcriptional regulator 544141 ybcM 8175390 ybcM Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003043721.1 543344 D 413997 CDS YP_003043722.1 254160614 8178364 544356..544811 1 NC_012967.1 DLP12 prophage; hypothetical protein 544811 ybcN 8178364 ybcN Escherichia coli B str. REL606 hypothetical protein YP_003043722.1 544356 D 413997 CDS YP_003043723.1 254160615 8175391 544811..544981 1 NC_012967.1 DLP12 prophage; conserved protein similar to phage 82 and lambda proteins; prophage protein NinE 544981 ninE 8175391 ninE Escherichia coli B str. REL606 prophage protein NinE YP_003043723.1 544811 D 413997 CDS YP_003043724.1 254160616 8178365 544974..545264 1 NC_012967.1 similar to b0549; hypothetical protein 545264 ybcO 8178365 ybcO Escherichia coli B str. REL606 hypothetical protein YP_003043724.1 544974 D 413997 CDS YP_003043725.1 254160617 8175392 545261..545623 1 NC_012967.1 DLP12 prophage; Holliday junction resolvase; endodeoxyribonuclease RUS 545623 rus 8175392 rus Escherichia coli B str. REL606 endodeoxyribonuclease RUS YP_003043725.1 545261 D 413997 CDS YP_003043726.1 254160618 8175393 545620..545760 1 NC_012967.1 similar to b4509; hypothetical protein 545760 ylcG 8175393 ylcG Escherichia coli B str. REL606 hypothetical protein YP_003043726.1 545620 D 413997 CDS YP_003043727.1 254160619 8178366 545846..546229 1 NC_012967.1 similar to b0551; putative antitermination protein 546229 ybcQ 8178366 ybcQ Escherichia coli B str. REL606 putative antitermination protein YP_003043727.1 545846 D 413997 CDS YP_003043728.1 254160620 8175395 complement(546947..547450) 1 NC_012967.1 IS1 protein InsB 547450 insB-6 8175395 insB-6 Escherichia coli B str. REL606 IS1 protein InsB YP_003043728.1 546947 R 413997 CDS YP_003043729.1 254160621 8175396 complement(547369..547644) 1 NC_012967.1 IS1 protein InsA 547644 insA-6 8175396 insA-6 Escherichia coli B str. REL606 IS1 protein InsA YP_003043729.1 547369 R 413997 CDS YP_003043730.1 254160622 8175397 548867..549082 1 NC_012967.1 similar to b0554; putative phage lysis protein 549082 ybcR 8175397 ybcR Escherichia coli B str. REL606 putative phage lysis protein YP_003043730.1 548867 D 413997 CDS YP_003043731.1 254160623 8178918 549082..549579 1 NC_012967.1 similar to b0555; putative lysozyme 549579 ybcS 8178918 ybcS Escherichia coli B str. REL606 putative lysozyme YP_003043731.1 549082 D 413997 CDS YP_003043732.1 254160624 8175398 549576..550037 1 NC_012967.1 similar to b0556; putative murein endopeptidase 550037 ybcT 8175398 ybcT Escherichia coli B str. REL606 putative murein endopeptidase YP_003043732.1 549576 D 413997 CDS YP_003043733.1 254160625 8175399 complement(550069..550362) 1 NC_012967.1 similar to b0557; putative lipoprotein 550362 ybcU 8175399 ybcU Escherichia coli B str. REL606 putative lipoprotein YP_003043733.1 550069 R 413997 CDS YP_003043734.1 254160626 8175400 complement(550723..550917) 1 NC_012967.1 hypothetical protein 550917 8175400 ECB_00510 Escherichia coli B str. REL606 hypothetical protein YP_003043734.1 550723 R 413997 CDS YP_003043735.1 254160627 8178367 551306..551881 1 NC_012967.1 similar to b0560; DNA packaging protein 551881 nohB 8178367 nohB Escherichia coli B str. REL606 DNA packaging protein YP_003043735.1 551306 D 413997 CDS YP_003043736.1 254160628 8175401 551841..554657 1 NC_012967.1 putative tail component of prophage 554657 8175401 ECB_00512 Escherichia coli B str. REL606 putative tail component of prophage YP_003043736.1 551841 D 413997 CDS YP_003043737.1 254160629 8175402 554716..557061 1 NC_012967.1 hypothetical protein 557061 8175402 ECB_00513 Escherichia coli B str. REL606 hypothetical protein YP_003043737.1 554716 D 413997 CDS YP_003043738.1 254160630 8178919 557058..557339 1 NC_012967.1 hypothetical protein 557339 8178919 ECB_00514 Escherichia coli B str. REL606 hypothetical protein YP_003043738.1 557058 D 413997 CDS YP_003043739.1 254160631 8175403 557349..558053 1 NC_012967.1 hypothetical protein 558053 8175403 ECB_00515 Escherichia coli B str. REL606 hypothetical protein YP_003043739.1 557349 D 413997 CDS YP_003043740.1 254160632 8178368 558064..558357 1 NC_012967.1 hypothetical protein 558357 8178368 ECB_00516 Escherichia coli B str. REL606 hypothetical protein YP_003043740.1 558064 D 413997 CDS YP_003043741.1 254160633 8175404 complement(558112..558447) 1 NC_012967.1 hypothetical protein 558447 8175404 ECB_00517 Escherichia coli B str. REL606 hypothetical protein YP_003043741.1 558112 R 413997 CDS YP_003043742.1 254160634 8175405 559033..559782 1 NC_012967.1 similar to b0564; DNA-binding transcriptional activator 559782 appY 8175405 appY Escherichia coli B str. REL606 DNA-binding transcriptional activator YP_003043742.1 559033 D 413997 CDS YP_003043743.1 254160635 8175406 complement(560031..560984) 1 NC_012967.1 outer membrane protease; involved in virulence in many organisms; OmpT; IcsP; SopA; Pla; PgtE; omptin; in Escherichia coli OmpT can degrade antimicrobial peptides; in Yersinia Pla activates plasminogen during infection; in Shigella flexneria SopA cleaves the autotransporter IcsA; outer membrane protease 560984 ompT 8175406 ompT Escherichia coli B str. REL606 outer membrane protease YP_003043743.1 560031 R 413997 CDS YP_003043744.1 254160636 8175407 complement(561498..562259) 1 NC_012967.1 similar to b0566; DNA-binding transcriptional activator of porin biosynthesis 562259 envY 8175407 envY Escherichia coli B str. REL606 DNA-binding transcriptional activator of porin biosynthesis YP_003043744.1 561498 R 413997 CDS YP_003043745.1 254160637 8175408 complement(562442..563332) 1 NC_012967.1 similar to b0567; hypothetical protein 563332 ybcH 8175408 ybcH Escherichia coli B str. REL606 hypothetical protein YP_003043745.1 562442 R 413997 CDS YP_003043746.1 254160638 8175409 complement(563333..566305) 1 NC_012967.1 similar to b0568; bacteriophage N4 receptor, outer membrane subunit 566305 nfrA 8175409 nfrA Escherichia coli B str. REL606 bacteriophage N4 receptor, outer membrane subunit YP_003043746.1 563333 R 413997 CDS YP_003043747.1 254160639 8178920 complement(568652..568822) 1 NC_012967.1 bacteriophage N4 receptor, inner membrane subunit 568822 8178920 ECB_00524 Escherichia coli B str. REL606 bacteriophage N4 receptor, inner membrane subunit YP_003043747.1 568652 R 413997 CDS YP_003043748.1 254160640 8175411 complement(568800..569936) 1 NC_012967.1 similar to b3484; putative transposase 569936 yhhI-2 8175411 yhhI-2 Escherichia coli B str. REL606 putative transposase YP_003043748.1 568800 R 413997 CDS YP_003043749.1 254160641 8175412 complement(570615..570776) 1 NC_012967.1 hypothetical protein 570776 8175412 ECB_00526 Escherichia coli B str. REL606 hypothetical protein YP_003043749.1 570615 R 413997 CDS YP_003043750.1 254160642 8175413 complement(570901..571191) 1 NC_012967.1 hypothetical protein 571191 8175413 ECB_00527 Escherichia coli B str. REL606 hypothetical protein YP_003043750.1 570901 R 413997 CDS YP_003043751.1 254160643 8178369 complement(571188..571448) 1 NC_012967.1 hypothetical protein 571448 8178369 ECB_00528 Escherichia coli B str. REL606 hypothetical protein YP_003043751.1 571188 R 413997 CDS YP_003043752.1 254160644 8175414 complement(571481..572038) 1 NC_012967.1 hypothetical protein 572038 8175414 ECB_00529 Escherichia coli B str. REL606 hypothetical protein YP_003043752.1 571481 R 413997 CDS YP_003043753.1 254160645 8175415 complement(571890..573488) 1 NC_012967.1 hypothetical protein 573488 8175415 ECB_00530 Escherichia coli B str. REL606 hypothetical protein YP_003043753.1 571890 R 413997 CDS YP_003043754.1 254160646 8175416 complement(574225..575673) 1 NC_012967.1 similar to b0570; sensor kinase CusS 575673 cusS 8175416 cusS Escherichia coli B str. REL606 sensor kinase CusS YP_003043754.1 574225 R 413997 CDS YP_003043755.1 254160647 8175417 complement(575663..576346) 1 NC_012967.1 response regulator in two-component regulatory system with CusS; regulates the copper efflux system; DNA-binding transcriptional activator CusR 576346 cusR 8175417 cusR Escherichia coli B str. REL606 DNA-binding transcriptional activator CusR YP_003043755.1 575663 R 413997 CDS YP_003043756.1 254160648 8175418 576503..577876 1 NC_012967.1 with CusA, CusB and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system outer membrane protein CusC 577876 cusC 8175418 cusC Escherichia coli B str. REL606 copper/silver efflux system outer membrane protein CusC YP_003043756.1 576503 D 413997 CDS YP_003043757.1 254160649 8175419 578034..578366 1 NC_012967.1 similar to b0573; periplasmic copper-binding protein 578366 ylcC 8175419 ylcC Escherichia coli B str. REL606 periplasmic copper-binding protein YP_003043757.1 578034 D 413997 CDS YP_003043758.1 254160650 8178921 578382..579605 1 NC_012967.1 with CusA, CusC and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system membrane fusion protein CusB 579605 cusB 8178921 cusB Escherichia coli B str. REL606 copper/silver efflux system membrane fusion protein CusB YP_003043758.1 578382 D 413997 CDS YP_003043759.1 254160651 8175420 579617..582760 1 NC_012967.1 similar to b0575; copper/silver efflux system, membrane component 582760 cusA 8175420 cusA Escherichia coli B str. REL606 copper/silver efflux system, membrane component YP_003043759.1 579617 D 413997 CDS YP_003043760.1 254160652 8175421 582862..584238 1 NC_012967.1 similar to b0576; phenylalanine transporter 584238 pheP 8175421 pheP Escherichia coli B str. REL606 phenylalanine transporter YP_003043760.1 582862 D 413997 CDS YP_003043761.1 254160653 8175422 complement(584306..585553) 1 NC_012967.1 similar to b0577; putative mechanosensitive channel 585553 ybdG 8175422 ybdG Escherichia coli B str. REL606 putative mechanosensitive channel YP_003043761.1 584306 R 413997 CDS YP_003043762.1 254160654 8175423 complement(585661..586314) 1 NC_012967.1 catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive; dihydropteridine reductase 586314 nfnB 8175423 nfnB Escherichia coli B str. REL606 dihydropteridine reductase YP_003043762.1 585661 R 413997 CDS YP_003043763.1 254160655 8178922 complement(586408..586776) 1 NC_012967.1 similar to b0579; hypothetical protein 586776 ybdF 8178922 ybdF Escherichia coli B str. REL606 hypothetical protein YP_003043763.1 586408 R 413997 CDS YP_003043764.1 254160656 8175424 complement(586841..587089) 1 NC_012967.1 similar to b0580; putative inner membrane protein 587089 ybdJ 8175424 ybdJ Escherichia coli B str. REL606 putative inner membrane protein YP_003043764.1 586841 R 413997 CDS YP_003043765.1 254160657 8175425 complement(587155..588273) 1 NC_012967.1 ATP-dependent; carboxylate-amine ligase with weak glutamate--cysteine ligase activity; carboxylate-amine ligase 588273 ybdK 8175425 ybdK Escherichia coli B str. REL606 carboxylate-amine ligase YP_003043765.1 587155 R 413997 CDS YP_003043766.1 254160658 8175426 588542..589063 1 NC_012967.1 IS150 protein InsA 589063 insJ-1 8175426 insJ-1 Escherichia coli B str. REL606 IS150 protein InsA YP_003043766.1 588542 D 413997 CDS YP_003043767.1 254160659 8178923 complement(589570..590073) 1 NC_012967.1 IS1 protein insB 590073 insB-7 8178923 insB-7 Escherichia coli B str. REL606 IS1 protein insB YP_003043767.1 589570 R 413997 CDS YP_003043768.1 254160660 8175428 complement(589992..590267) 1 NC_012967.1 IS1 protein InsA 590267 insA-7 8175428 insA-7 Escherichia coli B str. REL606 IS1 protein InsA YP_003043768.1 589992 R 413997 CDS YP_003043769.1 254160661 8175429 590543..590695 1 NC_012967.1 similar to b4415; toxic polypeptide, small 590695 hokE 8175429 hokE Escherichia coli B str. REL606 toxic polypeptide, small YP_003043769.1 590543 D 413997 CDS YP_003043770.1 254160662 8175430 590772..591884 1 NC_012967.1 IS186/IS421 transposase 591884 insL-3 8175430 insL-3 Escherichia coli B str. REL606 IS186/IS421 transposase YP_003043770.1 590772 D 413997 CDS YP_003043771.1 254160663 8175431 complement(592166..592795) 1 NC_012967.1 similar to b0583; phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex 592795 entD 8175431 entD Escherichia coli B str. REL606 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex YP_003043771.1 592166 R 413997 CDS YP_003043772.1 254160664 8178370 complement(592961..595201) 1 NC_012967.1 Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space; outer membrane receptor FepA 595201 fepA 8178370 fepA Escherichia coli B str. REL606 outer membrane receptor FepA YP_003043772.1 592961 R 413997 CDS YP_003043773.1 254160665 8175432 595523..596647 1 NC_012967.1 similar to b0585; enterobactin/ferric enterobactin esterase 596647 fes 8175432 fes Escherichia coli B str. REL606 enterobactin/ferric enterobactin esterase YP_003043773.1 595523 D 413997 CDS YP_003043774.1 254160666 8178924 596650..596868 1 NC_012967.1 similar to b4511; hypothetical protein 596868 ybdZ 8178924 ybdZ Escherichia coli B str. REL606 hypothetical protein YP_003043774.1 596650 D 413997 CDS YP_003043775.1 254160667 8175433 596865..600746 1 NC_012967.1 with EntB, EntD, and EntE forms the multienzyme complex enterobactin synthase; EntF is the serine activating enzyme which catalyzes the formation of the amide and ester bonds of the cyclic enterobactin; enterobactin synthase subunit F 600746 entF 8175433 entF Escherichia coli B str. REL606 enterobactin synthase subunit F YP_003043775.1 596865 D 413997 CDS YP_003043776.1 254160668 8175434 600962..602095 1 NC_012967.1 part of the ferric enterobactin transport system; necessary for enetrobactin uptake; ferric enterobactin transport protein FepE 602095 fepE 8175434 fepE Escherichia coli B str. REL606 ferric enterobactin transport protein FepE YP_003043776.1 600962 D 413997 CDS YP_003043777.1 254160669 8178925 complement(602092..602907) 1 NC_012967.1 with FepBDE is involved in the transport of ferric enterobactin; iron-enterobactin transporter ATP-binding protein 602907 fepC 8178925 fepC Escherichia coli B str. REL606 iron-enterobactin transporter ATP-binding protein YP_003043777.1 602092 R 413997 CDS YP_003043778.1 254160670 8175435 complement(602904..603896) 1 NC_012967.1 with FepBCD is involved in the transport of ferric enterobactin; iron-enterobactin transporter permease 603896 fepG 8175435 fepG Escherichia coli B str. REL606 iron-enterobactin transporter permease YP_003043778.1 602904 R 413997 CDS YP_003043779.1 254160671 8178926 complement(603893..604897) 1 NC_012967.1 with FepBCG is involved in the transport of ferric enterobactin; iron-enterobactin transporter membrane protein 604897 fepD 8178926 fepD Escherichia coli B str. REL606 iron-enterobactin transporter membrane protein YP_003043779.1 603893 R 413997 CDS YP_003043780.1 254160672 8175436 605008..606258 1 NC_012967.1 protein p43; inner membrane protein that exports enterobactin to the periplasmic space; member of the major facilitator superfamily (MFS) of transporters; enterobactin exporter EntS 606258 ybdA 8175436 ybdA Escherichia coli B str. REL606 enterobactin exporter EntS YP_003043780.1 605008 D 413997 CDS YP_003043781.1 254160673 8175437 complement(606262..607218) 1 NC_012967.1 with FepCDG is involved in the transport of ferric enterobactin; iron-enterobactin transporter periplasmic binding protein 607218 fepB 8175437 fepB Escherichia coli B str. REL606 iron-enterobactin transporter periplasmic binding protein YP_003043781.1 606262 R 413997 CDS YP_003043782.1 254160674 8175438 607593..608768 1 NC_012967.1 similar to b0593; isochorismate synthase 608768 entC 8175438 entC Escherichia coli B str. REL606 isochorismate synthase YP_003043782.1 607593 D 413997 CDS YP_003043783.1 254160675 8175439 608778..610388 1 NC_012967.1 bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate; enterobactin synthase subunit E 610388 entE 8175439 entE Escherichia coli B str. REL606 enterobactin synthase subunit E YP_003043783.1 608778 D 413997 CDS YP_003043784.1 254160676 8178371 610402..611259 1 NC_012967.1 similar to b0595; isochorismatase 611259 entB 8178371 entB Escherichia coli B str. REL606 isochorismatase YP_003043784.1 610402 D 413997 CDS YP_003043785.1 254160677 8175440 611259..612005 1 NC_012967.1 catalyzes the formation of 2,3-dihydroxybenzoate from 2,3-dihydro-2,3-dihydroxybenzoate; involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin; 2,3-dihydroxybenzoate-2,3-dehydrogenase 612005 entA 8175440 entA Escherichia coli B str. REL606 2,3-dihydroxybenzoate-2,3-dehydrogenase YP_003043785.1 611259 D 413997 CDS YP_003043786.1 254160678 8178372 612008..612421 1 NC_012967.1 similar to b0597; hypothetical protein 612421 ybdB 8178372 ybdB Escherichia coli B str. REL606 hypothetical protein YP_003043786.1 612008 D 413997 CDS YP_003043787.1 254160679 8175442 614879..615076 1 NC_012967.1 similar to b4512; hypothetical protein 615076 ybdD 8175442 ybdD Escherichia coli B str. REL606 hypothetical protein YP_003043787.1 614879 D 413997 CDS YP_003043788.1 254160680 8178373 complement(615086..616174) 1 NC_012967.1 member of the iron-containing alcohol dehydrogenase family; unknown function; hypothetical protein 616174 ybdH 8178373 ybdH Escherichia coli B str. REL606 hypothetical protein YP_003043788.1 615086 R 413997 CDS YP_003043789.1 254160681 8175443 616283..617443 1 NC_012967.1 catalyzes the transfer of an amino moiety; putative aminotransferase 617443 ybdL 8175443 ybdL Escherichia coli B str. REL606 putative aminotransferase YP_003043789.1 616283 D 413997 CDS YP_003043790.1 254160682 8175444 complement(617444..618073) 1 NC_012967.1 similar to b0601; hypothetical protein 618073 ybdM 8175444 ybdM Escherichia coli B str. REL606 hypothetical protein YP_003043790.1 617444 R 413997 CDS YP_003043791.1 254160683 8178374 complement(618046..619107) 1 NC_012967.1 similar to b0602; hypothetical protein 619107 ybdN 8178374 ybdN Escherichia coli B str. REL606 hypothetical protein YP_003043791.1 618046 R 413997 CDS YP_003043792.1 254160684 8175445 complement(619132..619635) 1 NC_012967.1 IS1 protein InsB 619635 insB-8 8175445 insB-8 Escherichia coli B str. REL606 IS1 protein InsB YP_003043792.1 619132 R 413997 CDS YP_003043793.1 254160685 8178375 complement(619554..619829) 1 NC_012967.1 IS1 protein InsA 619829 insA-8 8178375 insA-8 Escherichia coli B str. REL606 IS1 protein InsA YP_003043793.1 619554 R 413997 CDS YP_003043794.1 254160686 8175446 complement(619863..620624) 1 NC_012967.1 Involved in disulfide bond formation; disulfide isomerase/thiol-disulfide oxidase 620624 dsbG 8175446 dsbG Escherichia coli B str. REL606 disulfide isomerase/thiol-disulfide oxidase YP_003043794.1 619863 R 413997 CDS YP_003043795.1 254160687 8175447 620996..621559 1 NC_012967.1 with AhpF catalyzes the conversion of alkyl hydroperoxides to their corresponding alcohols; AhpC reduced the hydroperoxide substrate; alkyl hydroperoxide reductase subunit C 621559 ahpC 8175447 ahpC Escherichia coli B str. REL606 alkyl hydroperoxide reductase subunit C YP_003043795.1 620996 D 413997 CDS YP_003043796.1 254160688 8178376 621804..623369 1 NC_012967.1 similar to b0606; alkyl hydroperoxide reductase, F52a subunit, FAD/NAD(P)-binding 623369 ahpF 8178376 ahpF Escherichia coli B str. REL606 alkyl hydroperoxide reductase, F52a subunit, FAD/NAD(P)-binding YP_003043796.1 621804 D 413997 CDS YP_003043797.1 254160689 8175448 complement(623490..623918) 1 NC_012967.1 similar to b0607; universal stress protein UP12 623918 ybdQ 8175448 ybdQ Escherichia coli B str. REL606 universal stress protein UP12 YP_003043797.1 623490 R 413997 CDS YP_003043798.1 254160690 8175449 624139..625377 1 NC_012967.1 similar to b0608; putative oxidoreductase, Zn-dependent and NAD(P)-binding 625377 ybdR 8175449 ybdR Escherichia coli B str. REL606 putative oxidoreductase, Zn-dependent and NAD(P)-binding YP_003043798.1 624139 D 413997 CDS YP_003043799.1 254160691 8175450 complement(625608..626018) 1 NC_012967.1 Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation; nucleoside diphosphate kinase regulator 626018 rnk 8175450 rnk Escherichia coli B str. REL606 nucleoside diphosphate kinase regulator YP_003043799.1 625608 R 413997 CDS YP_003043800.1 254160692 8175451 complement(626248..627054) 1 NC_012967.1 similar to b0611; ribonuclease I 627054 rna 8175451 rna Escherichia coli B str. REL606 ribonuclease I YP_003043800.1 626248 R 413997 CDS YP_003043801.1 254160693 8178927 complement(627168..628631) 1 NC_012967.1 similar to b0612; citrate:succinate antiporter 628631 citT 8178927 citT Escherichia coli B str. REL606 citrate:succinate antiporter YP_003043801.1 627168 R 413997 CDS YP_003043802.1 254160694 8175452 complement(628682..629560) 1 NC_012967.1 catalyzes the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA from ATP and 3-dephospho-CoA; triphosphoribosyl-dephospho-CoA synthase 629560 citG 8175452 citG Escherichia coli B str. REL606 triphosphoribosyl-dephospho-CoA synthase YP_003043802.1 628682 R 413997 CDS YP_003043803.1 254160695 8175453 complement(629535..630086) 1 NC_012967.1 2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase; holo-citrate lyase synthase; CitG forms the prosthetic group precursor 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA which is then transferred to apo-ACP by CitX to produce holo-ACP and pyrophosphate; 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo- citrate lyase 630086 citX 8175453 citX Escherichia coli B str. REL606 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo- citrate lyase YP_003043803.1 629535 R 413997 CDS YP_003043804.1 254160696 8175454 complement(630090..631622) 1 NC_012967.1 similar to b0615; citrate lyase, citrate-ACP transferase subunit alpha 631622 citF 8175454 citF Escherichia coli B str. REL606 citrate lyase, citrate-ACP transferase subunit alpha YP_003043804.1 630090 R 413997 CDS YP_003043805.1 254160697 8178377 complement(631633..632541) 1 NC_012967.1 similar to b0616; citrate lyase, citryl-ACP lyase subunit beta 632541 citE 8178377 citE Escherichia coli B str. REL606 citrate lyase, citryl-ACP lyase subunit beta YP_003043805.1 631633 R 413997 CDS YP_003043806.1 254160698 8175455 complement(632538..632834) 1 NC_012967.1 acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate; citrate lyase subunit gamma 632834 citD 8175455 citD Escherichia coli B str. REL606 citrate lyase subunit gamma YP_003043806.1 632538 R 413997 CDS YP_003043807.1 254160699 8175456 complement(632849..633907) 1 NC_012967.1 similar to b0618; citrate lyase synthetase 633907 citC 8175456 citC Escherichia coli B str. REL606 citrate lyase synthetase YP_003043807.1 632849 R 413997 CDS YP_003043808.1 254160700 8178378 complement(633993..634496) 1 NC_012967.1 IS1 protein InsB 634496 insB-9 8178378 insB-9 Escherichia coli B str. REL606 IS1 protein InsB YP_003043808.1 633993 R 413997 CDS YP_003043809.1 254160701 8175457 complement(634415..634690) 1 NC_012967.1 IS1 protein InsA 634690 insA-9 8175457 insA-9 Escherichia coli B str. REL606 IS1 protein InsA YP_003043809.1 634415 R 413997 CDS YP_003043810.1 254160702 8175458 634823..636481 1 NC_012967.1 similar to b0619; sensory histidine kinase in two-component regulatory system with citB 636481 citA 8175458 citA Escherichia coli B str. REL606 sensory histidine kinase in two-component regulatory system with citB YP_003043810.1 634823 D 413997 CDS YP_003043811.1 254160703 8175459 636450..637130 1 NC_012967.1 regulates the expression of citAB in citrate fermentation; two-component response regulator DpiA 637130 dpiA 8175459 dpiA Escherichia coli B str. REL606 two-component response regulator DpiA YP_003043811.1 636450 D 413997 CDS YP_003043812.1 254160704 8175460 complement(637171..638556) 1 NC_012967.1 responsible for the transport of C4-dicarboxylates during anaerobic growth; C4-dicarboxylate transporter DcuC 638556 dcuC 8175460 dcuC Escherichia coli B str. REL606 C4-dicarboxylate transporter DcuC YP_003043812.1 637171 R 413997 CDS YP_003043813.1 254160705 8178928 639144..639704 1 NC_012967.1 catalyzes the transfer of palmitate to lipid A; palmitoyl transferase 639704 pagP 8178928 pagP Escherichia coli B str. REL606 palmitoyl transferase YP_003043813.1 639144 D 413997 CDS YP_003043814.1 254160706 8175461 639873..640082 1 NC_012967.1 member of the CspA family; constitutively expressed RNA/ssDNA-binding protein; functions in helping cells adapt to low temperature; aids nucleic acid melting; participates in gene regulation; can act as a transcription antiterminator; cold shock protein CspE 640082 cspE 8175461 cspE Escherichia coli B str. REL606 cold shock protein CspE YP_003043814.1 639873 D 413997 CDS YP_003043815.1 254160707 8175462 complement(640137..640520) 1 NC_012967.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 640520 ccrB 8175462 ccrB Escherichia coli B str. REL606 camphor resistance protein CrcB YP_003043815.1 640137 R 413997 CDS YP_003043816.1 254160708 8175463 640613..641401 1 NC_012967.1 similar to b0625-b0626; putative NAD(P)-binding amidase-type enzyme YbeM (C-N hydrolase family) 641401 ybeM 8175463 ybeM Escherichia coli B str. REL606 putative NAD(P)-binding amidase-type enzyme YbeM (C-N hydrolase family) YP_003043816.1 640613 D 413997 CDS YP_003043817.1 254160709 8175464 641530..641733 1 NC_012967.1 TatE; similar to TatA and found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase protein E 641733 tatE 8175464 tatE Escherichia coli B str. REL606 twin arginine translocase protein E YP_003043817.1 641530 D 413997 CDS YP_003043818.1 254160710 8178929 complement(641834..642799) 1 NC_012967.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 642799 lipA 8178929 lipA Escherichia coli B str. REL606 lipoyl synthase YP_003043818.1 641834 R 413997 CDS YP_003043819.1 254160711 8175465 complement(643008..643961) 1 NC_012967.1 similar to b0629; putative DNA-binding transcriptional regulator 643961 ybeF 8175465 ybeF Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003043819.1 643008 R 413997 CDS YP_003043820.1 254160712 8175466 complement(644220..644861) 1 NC_012967.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B 644861 lipB 8175466 lipB Escherichia coli B str. REL606 lipoate-protein ligase B YP_003043820.1 644220 R 413997 CDS YP_003043821.1 254160713 8178930 complement(644962..645225) 1 NC_012967.1 similar to b0631; hypothetical protein 645225 ybeD 8178930 ybeD Escherichia coli B str. REL606 hypothetical protein YP_003043821.1 644962 R 413997 CDS YP_003043822.1 254160714 8175467 complement(645335..646546) 1 NC_012967.1 penicillin-binding protein 5; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; D-alanyl-D-alanine carboxypeptidase fraction A 646546 dacA 8175467 dacA Escherichia coli B str. REL606 D-alanyl-D-alanine carboxypeptidase fraction A YP_003043822.1 645335 R 413997 CDS YP_003043823.1 254160715 8175468 complement(646686..647774) 1 NC_012967.1 similar to b0633; rare lipoprotein A 647774 rlpA 8175468 rlpA Escherichia coli B str. REL606 rare lipoprotein A YP_003043823.1 646686 R 413997 CDS YP_003043824.1 254160716 8175469 complement(647785..648897) 1 NC_012967.1 similar to b0634; cell wall shape-determining protein 648897 mrdB 8175469 mrdB Escherichia coli B str. REL606 cell wall shape-determining protein YP_003043824.1 647785 R 413997 CDS YP_003043825.1 254160717 8175470 complement(648900..650801) 1 NC_012967.1 similar to b0635; penicillin-binding protein 2 650801 mrdA 8175470 mrdA Escherichia coli B str. REL606 penicillin-binding protein 2 YP_003043825.1 648900 R 413997 CDS YP_003043826.1 254160718 8178931 complement(650832..651299) 1 NC_012967.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase 651299 ybeA 8178931 ybeA Escherichia coli B str. REL606 rRNA large subunit methyltransferase YP_003043826.1 650832 R 413997 CDS YP_003043827.1 254160719 8175471 complement(651303..651620) 1 NC_012967.1 similar to b0637; hypothetical protein 651620 ybeB 8175471 ybeB Escherichia coli B str. REL606 hypothetical protein YP_003043827.1 651303 R 413997 CDS YP_003043828.1 254160720 8175472 complement(651880..652491) 1 NC_012967.1 similar to b0638; putative alpha-ribazole-5'-P phosphatase 652491 phpB 8175472 phpB Escherichia coli B str. REL606 putative alpha-ribazole-5'-P phosphatase YP_003043828.1 651880 R 413997 CDS YP_003043829.1 254160721 8175473 complement(652515..653156) 1 NC_012967.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase 653156 nadD 8175473 nadD Escherichia coli B str. REL606 nicotinic acid mononucleotide adenylyltransferase YP_003043829.1 652515 R 413997 CDS YP_003043830.1 254160722 8175474 complement(653158..654189) 1 NC_012967.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 654189 holA 8175474 holA Escherichia coli B str. REL606 DNA polymerase III subunit delta YP_003043830.1 653158 R 413997 CDS YP_003043831.1 254160723 8178932 complement(654189..654770) 1 NC_012967.1 rare lipoprotein B; involved in the assembly of LPS in the outer membrane; LPS-assembly lipoprotein RlpB 654770 rlpB 8178932 rlpB Escherichia coli B str. REL606 LPS-assembly lipoprotein RlpB YP_003043831.1 654189 R 413997 CDS YP_003043832.1 254160724 8175475 complement(654785..657367) 1 NC_012967.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 657367 leuS 8175475 leuS Escherichia coli B str. REL606 leucyl-tRNA synthetase YP_003043832.1 654785 R 413997 CDS YP_003043833.1 254160725 8175476 657602..658084 1 NC_012967.1 similar to b0643; hypothetical protein 658084 ybeL 8175476 ybeL Escherichia coli B str. REL606 hypothetical protein YP_003043833.1 657602 D 413997 CDS YP_003043834.1 254160726 8175478 659295..660002 1 NC_012967.1 similar to b0645; hypothetical protein 660002 ybeR 8175478 ybeR Escherichia coli B str. REL606 hypothetical protein YP_003043834.1 659295 D 413997 CDS YP_003043835.1 254160727 8175479 660310..661449 1 NC_012967.1 similar to b0649; Hsc56 co-chaperone of HscC 661449 ybeV 8175479 ybeV Escherichia coli B str. REL606 Hsc56 co-chaperone of HscC YP_003043835.1 660310 D 413997 CDS YP_003043836.1 254160728 8175480 complement(661509..663179) 1 NC_012967.1 similar to b0650; Hsp70 family chaperone Hsc62, binds to RpoD and inhibits transcription 663179 hscC 8175480 hscC Escherichia coli B str. REL606 Hsp70 family chaperone Hsc62, binds to RpoD and inhibits transcription YP_003043836.1 661509 R 413997 CDS YP_003043837.1 254160729 8175481 complement(663263..664198) 1 NC_012967.1 Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively; pyrimidine-specific; ribonucleoside hydrolase 1 664198 rihA 8175481 rihA Escherichia coli B str. REL606 ribonucleoside hydrolase 1 YP_003043837.1 663263 R 413997 CDS YP_003043838.1 254160730 8175483 664735..665256 1 NC_012967.1 IS150 transposase A 665256 insJ-2 8175483 insJ-2 Escherichia coli B str. REL606 IS150 transposase A YP_003043838.1 664735 D 413997 CDS YP_003043839.1 254160731 8175484 665253..666104 1 NC_012967.1 IS150 putative transposase 666104 insK-2 8175484 insK-2 Escherichia coli B str. REL606 IS150 putative transposase YP_003043839.1 665253 D 413997 CDS YP_003043840.1 254160732 8175485 complement(666487..667161) 1 NC_012967.1 similar to b0653; glutamate and aspartate transporter subunit 667161 gltK 8175485 gltK Escherichia coli B str. REL606 glutamate and aspartate transporter subunit YP_003043840.1 666487 R 413997 CDS YP_003043841.1 254160733 8175486 complement(667161..667901) 1 NC_012967.1 similar to b0654; glutamate and aspartate transporter subunit 667901 gltJ 8175486 gltJ Escherichia coli B str. REL606 glutamate and aspartate transporter subunit YP_003043841.1 667161 R 413997 CDS YP_003043842.1 254160734 8175487 complement(668071..668979) 1 NC_012967.1 similar to b0655; glutamate and aspartate transporter subunit 668979 gltI 8175487 gltI Escherichia coli B str. REL606 glutamate and aspartate transporter subunit YP_003043842.1 668071 R 413997 CDS YP_003043843.1 254160735 8175488 669434..671311 1 NC_012967.1 hypothetical protein 671311 8175488 ECB_00624 Escherichia coli B str. REL606 hypothetical protein YP_003043843.1 669434 D 413997 CDS YP_003043844.1 254160736 8175489 complement(671438..672976) 1 NC_012967.1 Transfers the fatty acyl group on membrane lipoproteins; apolipoprotein N-acyltransferase 672976 lnt 8175489 lnt Escherichia coli B str. REL606 apolipoprotein N-acyltransferase YP_003043844.1 671438 R 413997 CDS YP_003043845.1 254160737 8175490 complement(673001..673879) 1 NC_012967.1 similar to b0658; predicteed ion transport 673879 ybeX 8175490 ybeX Escherichia coli B str. REL606 predicteed ion transport YP_003043845.1 673001 R 413997 CDS YP_003043846.1 254160738 8178933 complement(673969..674436) 1 NC_012967.1 similar to b0659; putative metalloprotease 674436 ybeY 8178933 ybeY Escherichia coli B str. REL606 putative metalloprotease YP_003043846.1 673969 R 413997 CDS YP_003043847.1 254160739 8175491 complement(674433..675512) 1 NC_012967.1 similar to b0660; hypothetical protein 675512 ybeZ 8175491 ybeZ Escherichia coli B str. REL606 hypothetical protein YP_003043847.1 674433 R 413997 CDS YP_003043848.1 254160740 8178379 complement(675626..677050) 1 NC_012967.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase 677050 yleA 8178379 yleA Escherichia coli B str. REL606 (dimethylallyl)adenosine tRNA methylthiotransferase YP_003043848.1 675626 R 413997 CDS YP_003043849.1 254160741 8175492 677196..678371 1 NC_012967.1 catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol; functions in the biosynthesis of ubiquinone or coenzyme Q; 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase 678371 ubiF 8175492 ubiF Escherichia coli B str. REL606 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase YP_003043849.1 677196 D 413997 CDS YP_003043850.1 254160742 8175497 complement(679608..681272) 1 NC_012967.1 functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP; asparagine synthetase B 681272 asnB 8175497 asnB Escherichia coli B str. REL606 asparagine synthetase B YP_003043850.1 679608 R 413997 CDS YP_003043851.1 254160743 8178383 complement(681669..682421) 1 NC_012967.1 similar to b0675; UMP phosphatase 682421 nagD 8178383 nagD Escherichia coli B str. REL606 UMP phosphatase YP_003043851.1 681669 R 413997 CDS YP_003043852.1 254160744 8175498 complement(682469..683689) 1 NC_012967.1 similar to b0676; DNA-binding transcriptional dual regulator, repressor of N-acetylglucosamine 683689 nagC 8175498 nagC Escherichia coli B str. REL606 DNA-binding transcriptional dual regulator, repressor of N-acetylglucosamine YP_003043852.1 682469 R 413997 CDS YP_003043853.1 254160745 8175499 complement(683698..684846) 1 NC_012967.1 catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate; N-acetylglucosamine-6-phosphate deacetylase 684846 nagA 8175499 nagA Escherichia coli B str. REL606 N-acetylglucosamine-6-phosphate deacetylase YP_003043853.1 683698 R 413997 CDS YP_003043854.1 254160746 8175500 complement(684906..685706) 1 NC_012967.1 catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate; glucosamine-6-phosphate deaminase 685706 nagB 8175500 nagB Escherichia coli B str. REL606 glucosamine-6-phosphate deaminase YP_003043854.1 684906 R 413997 CDS YP_003043855.1 254160747 8175501 686039..687985 1 NC_012967.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system N-acetyl glucosamine specific transporter subunits IIABC 687985 nagE 8175501 nagE Escherichia coli B str. REL606 PTS system N-acetyl glucosamine specific transporter subunits IIABC YP_003043855.1 686039 D 413997 CDS YP_003043856.1 254160748 8175502 688188..689852 1 NC_012967.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glutaminyl-tRNA synthetase 689852 glnS 8175502 glnS Escherichia coli B str. REL606 glutaminyl-tRNA synthetase YP_003043856.1 688188 D 413997 CDS YP_003043857.1 254160749 8175503 690429..691835 1 NC_012967.1 similar to b0681; putative outer membrane porin 691835 ybfM 8175503 ybfM Escherichia coli B str. REL606 putative outer membrane porin YP_003043857.1 690429 D 413997 CDS YP_003043858.1 254160750 8178934 691885..692211 1 NC_012967.1 similar to b0682; putative lipoprotein 692211 ybfN 8178934 ybfN Escherichia coli B str. REL606 putative lipoprotein YP_003043858.1 691885 D 413997 CDS YP_003043859.1 254160751 8175504 complement(692295..692741) 1 NC_012967.1 negatively regulates a number of operons that encode enzymes involved in iron transport; activated by manganese; forms a homodimer; ferric uptake regulator 692741 fur 8175504 fur Escherichia coli B str. REL606 ferric uptake regulator YP_003043859.1 692295 R 413997 CDS YP_003043860.1 254160752 8175505 complement(693030..693560) 1 NC_012967.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin FldA 693560 fldA 8175505 fldA Escherichia coli B str. REL606 flavodoxin FldA YP_003043860.1 693030 R 413997 CDS YP_003043861.1 254160753 8178935 complement(693700..693993) 1 NC_012967.1 similar to b0685; LexA regulated protein 693993 ybfE 8178935 ybfE Escherichia coli B str. REL606 LexA regulated protein YP_003043861.1 693700 R 413997 CDS YP_003043862.1 254160754 8175506 complement(694133..694897) 1 NC_012967.1 similar to b0686; hypothetical protein 694897 ybfF 8175506 ybfF Escherichia coli B str. REL606 hypothetical protein YP_003043862.1 694133 R 413997 CDS YP_003043863.1 254160755 8175507 695082..695627 1 NC_012967.1 negative modulator of the initiation of chromosome replication; replication initiation regulator SeqA 695627 seqA 8175507 seqA Escherichia coli B str. REL606 replication initiation regulator SeqA YP_003043863.1 695082 D 413997 CDS YP_003043864.1 254160756 8175508 695653..697293 1 NC_012967.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase 697293 pgm 8175508 pgm Escherichia coli B str. REL606 phosphoglucomutase YP_003043864.1 695653 D 413997 CDS YP_003043865.1 254160757 8175509 697507..698001 1 NC_012967.1 similar to b0689; hypothetical protein 698001 ybfP 8175509 ybfP Escherichia coli B str. REL606 hypothetical protein YP_003043865.1 697507 D 413997 CDS YP_003043866.1 254160758 8178936 complement(698042..698692) 1 NC_012967.1 similar to b0690-b0691; hypothetical protein 698692 ybfGH 8178936 ybfGH Escherichia coli B str. REL606 hypothetical protein YP_003043866.1 698042 R 413997 CDS YP_003043867.1 254160759 8175510 complement(699041..700360) 1 NC_012967.1 catalyzes the uptake of putrescine via a proton symport mechanism, as well as the efflux of putrescine by a putrescine/ornithine antiport system; putrescine transporter 700360 potE 8175510 potE Escherichia coli B str. REL606 putrescine transporter YP_003043867.1 699041 R 413997 CDS YP_003043868.1 254160760 8175511 complement(700357..702555) 1 NC_012967.1 similar to b0693; ornithine decarboxylase 702555 speF 8175511 speF Escherichia coli B str. REL606 ornithine decarboxylase YP_003043868.1 700357 R 413997 CDS YP_003043869.1 254160761 8178384 702678..702935 1 NC_012967.1 hypothetical protein 702935 8178384 ECB_00650 Escherichia coli B str. REL606 hypothetical protein YP_003043869.1 702678 D 413997 CDS YP_003043870.1 254160762 8175512 complement(703151..703828) 1 NC_012967.1 response regulator in two-component regulatory system with KdpD; regulates the kdp operon involved in potassium transport; DNA-binding transcriptional activator KdpE 703828 kdpE 8175512 kdpE Escherichia coli B str. REL606 DNA-binding transcriptional activator KdpE YP_003043870.1 703151 R 413997 CDS YP_003043871.1 254160763 8175513 complement(703825..706512) 1 NC_012967.1 sensory histidine kinase in two-component regulatory system with KdpE; signal sensing protein; sensor protein KdpD 706512 kdpD 8175513 kdpD Escherichia coli B str. REL606 sensor protein KdpD YP_003043871.1 703825 R 413997 CDS YP_003043872.1 254160764 8175514 complement(706502..707074) 1 NC_012967.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex; potassium-transporting ATPase subunit C 707074 kdpC 8175514 kdpC Escherichia coli B str. REL606 potassium-transporting ATPase subunit C YP_003043872.1 706502 R 413997 CDS YP_003043873.1 254160765 8175515 complement(707083..709131) 1 NC_012967.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit B 709131 kdpB 8175515 kdpB Escherichia coli B str. REL606 potassium-transporting ATPase subunit B YP_003043873.1 707083 R 413997 CDS YP_003043874.1 254160766 8175516 complement(709154..710827) 1 NC_012967.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit A 710827 kdpA 8175516 kdpA Escherichia coli B str. REL606 potassium-transporting ATPase subunit A YP_003043874.1 709154 R 413997 CDS YP_003043875.1 254160767 8175517 complement(710827..710916) 1 NC_012967.1 one of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit F 710916 kdpF 8175517 kdpF Escherichia coli B str. REL606 potassium-transporting ATPase subunit F YP_003043875.1 710827 R 413997 CDS YP_003043876.1 254160768 8175518 711229..711435 1 NC_012967.1 similar to b0699; hypothetical protein 711435 ybfA 8175518 ybfA Escherichia coli B str. REL606 hypothetical protein YP_003043876.1 711229 D 413997 CDS YP_003043877.1 254160769 8175519 711856..713520 1 NC_012967.1 similar to b0700; rhsC element core protein RshC 713520 rhsC 8175519 rhsC Escherichia coli B str. REL606 rhsC element core protein RshC YP_003043877.1 711856 D 413997 CDS YP_003043878.1 254160770 8175520 713520..713846 1 NC_012967.1 similar to b0702; putative inner membrane protein 713846 ybfB 8175520 ybfB Escherichia coli B str. REL606 putative inner membrane protein YP_003043878.1 713520 D 413997 CDS YP_003043879.1 254160771 8178937 713964..715397 1 NC_012967.1 similar to b0703; hypothetical protein 715397 ybfO 8178937 ybfO Escherichia coli B str. REL606 hypothetical protein YP_003043879.1 713964 D 413997 CDS YP_003043880.1 254160772 8175521 715394..715963 1 NC_012967.1 similar to b0704; hypothetical protein 715963 ybfC 8175521 ybfC Escherichia coli B str. REL606 hypothetical protein YP_003043880.1 715394 D 413997 CDS YP_003043881.1 254160773 8175522 716159..716434 1 NC_012967.1 hypothetical protein 716434 8175522 ECB_00662 Escherichia coli B str. REL606 hypothetical protein YP_003043881.1 716159 D 413997 CDS YP_003043882.1 254160774 8175523 complement(716646..716924) 1 NC_012967.1 hypothetical protein 716924 8175523 ECB_00663 Escherichia coli B str. REL606 hypothetical protein YP_003043882.1 716646 R 413997 CDS YP_003043883.1 254160775 8178938 717143..717385 1 NC_012967.1 hypothetical protein 717385 8178938 ECB_00664 Escherichia coli B str. REL606 hypothetical protein YP_003043883.1 717143 D 413997 CDS YP_003043884.1 254160776 8175525 718985..719746 1 NC_012967.1 similar to b0706; hypothetical protein 719746 ybfD 8175525 ybfD Escherichia coli B str. REL606 hypothetical protein YP_003043884.1 718985 D 413997 CDS YP_003043885.1 254160777 8178939 719894..720403 1 NC_012967.1 similar to b0707; hypothetical protein 720403 ybgA 8178939 ybgA Escherichia coli B str. REL606 hypothetical protein YP_003043885.1 719894 D 413997 CDS YP_003043886.1 254160778 8175526 720400..721821 1 NC_012967.1 UV-induced DNA repair; converts cyclobutane-type pyrimidine dimers created during exposure to UV ratiation to monomers; light dependent; deoxyribodipyrimidine photolyase 721821 phrB 8175526 phrB Escherichia coli B str. REL606 deoxyribodipyrimidine photolyase YP_003043886.1 720400 D 413997 CDS YP_003043887.1 254160779 8178385 complement(721860..723341) 1 NC_012967.1 similar to b0709; putative transporter 723341 ybgH 8178385 ybgH Escherichia coli B str. REL606 putative transporter YP_003043887.1 721860 R 413997 CDS YP_003043888.1 254160780 8175527 723612..724355 1 NC_012967.1 similar to b0710; putative hydrolase-oxidase 724355 ybgI 8175527 ybgI Escherichia coli B str. REL606 putative hydrolase-oxidase YP_003043888.1 723612 D 413997 CDS YP_003043889.1 254160781 8175528 724378..725034 1 NC_012967.1 similar to b0711; hypothetical protein 725034 ybgJ 8175528 ybgJ Escherichia coli B str. REL606 hypothetical protein YP_003043889.1 724378 D 413997 CDS YP_003043890.1 254160782 8178386 725028..725960 1 NC_012967.1 similar to b0712; hypothetical protein 725960 ybgK 8178386 ybgK Escherichia coli B str. REL606 hypothetical protein YP_003043890.1 725028 D 413997 CDS YP_003043891.1 254160783 8175529 725950..726684 1 NC_012967.1 similar to b0713; LamB/YcsF family protein 726684 ybgL 8175529 ybgL Escherichia coli B str. REL606 LamB/YcsF family protein YP_003043891.1 725950 D 413997 CDS YP_003043892.1 254160784 8175530 726720..727511 1 NC_012967.1 5-formyluracil/5-hydroxymethyluracil DNA glycosylase; involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; acts as DNA glycosylase that recognizes and removes damaged bases with a preference for oxidized pyrimidines; has apurinic/apyrimidinic lyase activity; endonuclease VIII 727511 nei 8175530 nei Escherichia coli B str. REL606 endonuclease VIII YP_003043892.1 726720 D 413997 CDS YP_003043893.1 254160785 8175531 complement(727508..728554) 1 NC_012967.1 similar to b0715; putative regulator 728554 abrB 8175531 abrB Escherichia coli B str. REL606 putative regulator YP_003043893.1 727508 R 413997 CDS YP_003043894.1 254160786 8175532 complement(728706..729767) 1 NC_012967.1 similar to b0716; putative fimbrial-like adhesin protein 729767 ybgO 8175532 ybgO Escherichia coli B str. REL606 putative fimbrial-like adhesin protein YP_003043894.1 728706 R 413997 CDS YP_003043895.1 254160787 8178387 complement(729764..730495) 1 NC_012967.1 similar to b0717; putative assembly protein 730495 ybgP 8178387 ybgP Escherichia coli B str. REL606 putative assembly protein YP_003043895.1 729764 R 413997 CDS YP_003043896.1 254160788 8175533 complement(730510..732960) 1 NC_012967.1 similar to b0718; putative outer membrane protein 732960 ybgQ 8175533 ybgQ Escherichia coli B str. REL606 putative outer membrane protein YP_003043896.1 730510 R 413997 CDS YP_003043897.1 254160789 8175534 complement(733020..733586) 1 NC_012967.1 similar to b0719; putative fimbrial-like adhesin protein 733586 ybgD 8175534 ybgD Escherichia coli B str. REL606 putative fimbrial-like adhesin protein YP_003043897.1 733020 R 413997 CDS YP_003043898.1 254160790 8175535 complement(733976..735259) 1 NC_012967.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase 735259 gltA 8175535 gltA Escherichia coli B str. REL606 type II citrate synthase YP_003043898.1 733976 R 413997 CDS YP_003043899.1 254160791 8175536 735968..736357 1 NC_012967.1 similar to b0721; succinate dehydrogenase cytochrome b556 large membrane subunit 736357 sdhC 8175536 sdhC Escherichia coli B str. REL606 succinate dehydrogenase cytochrome b556 large membrane subunit YP_003043899.1 735968 D 413997 CDS YP_003043900.1 254160792 8175537 736351..736698 1 NC_012967.1 similar to b0722; succinate dehydrogenase cytochrome b556 small membrane subunit 736698 sdhD 8175537 sdhD Escherichia coli B str. REL606 succinate dehydrogenase cytochrome b556 small membrane subunit YP_003043900.1 736351 D 413997 CDS YP_003043901.1 254160793 8175538 736698..738464 1 NC_012967.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 738464 sdhA 8175538 sdhA Escherichia coli B str. REL606 succinate dehydrogenase flavoprotein subunit YP_003043901.1 736698 D 413997 CDS YP_003043902.1 254160794 8175539 738480..739196 1 NC_012967.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 739196 sdhB 8175539 sdhB Escherichia coli B str. REL606 succinate dehydrogenase iron-sulfur subunit YP_003043902.1 738480 D 413997 CDS YP_003043903.1 254160795 8175540 739497..742298 1 NC_012967.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 component 742298 sucA 8175540 sucA Escherichia coli B str. REL606 2-oxoglutarate dehydrogenase E1 component YP_003043903.1 739497 D 413997 CDS YP_003043904.1 254160796 8175541 742313..743530 1 NC_012967.1 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA; dihydrolipoamide succinyltransferase 743530 sucB 8175541 sucB Escherichia coli B str. REL606 dihydrolipoamide succinyltransferase YP_003043904.1 742313 D 413997 CDS YP_003043905.1 254160797 8178940 743896..745062 1 NC_012967.1 catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 745062 sucC 8178940 sucC Escherichia coli B str. REL606 succinyl-CoA synthetase subunit beta YP_003043905.1 743896 D 413997 CDS YP_003043906.1 254160798 8175542 745062..745931 1 NC_012967.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 745931 sucD 8175542 sucD Escherichia coli B str. REL606 succinyl-CoA synthetase subunit alpha YP_003043906.1 745062 D 413997 CDS YP_003043907.1 254160799 8175543 complement(746035..746757) 1 NC_012967.1 regulates the succiny-lCoA synthetase operon; DNA-binding transcriptional repressor MngR 746757 farR 8175543 farR Escherichia coli B str. REL606 DNA-binding transcriptional repressor MngR YP_003043907.1 746035 R 413997 CDS YP_003043908.1 254160800 8175544 746866..748842 1 NC_012967.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC 748842 hrsA 8175544 hrsA Escherichia coli B str. REL606 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC YP_003043908.1 746866 D 413997 CDS YP_003043909.1 254160801 8178388 748860..751493 1 NC_012967.1 similar to b0732; alpha-mannosidase 751493 ybgG 8178388 ybgG Escherichia coli B str. REL606 alpha-mannosidase YP_003043909.1 748860 D 413997 CDS YP_003043910.1 254160802 8175545 752340..753908 1 NC_012967.1 similar to b0733; cytochrome d terminal oxidase, subunit I 753908 cydA 8175545 cydA Escherichia coli B str. REL606 cytochrome d terminal oxidase, subunit I YP_003043910.1 752340 D 413997 CDS YP_003043911.1 254160803 8175546 753924..755063 1 NC_012967.1 similar to b0734; cytochrome d terminal oxidase, subunit II 755063 cydB 8175546 cydB Escherichia coli B str. REL606 cytochrome d terminal oxidase, subunit II YP_003043911.1 753924 D 413997 CDS YP_003043912.1 254160804 8175547 755078..755191 1 NC_012967.1 similar to b4515; hypothetical protein 755191 ybgT 8175547 ybgT Escherichia coli B str. REL606 hypothetical protein YP_003043912.1 755078 D 413997 CDS YP_003043913.1 254160805 8175548 755191..755484 1 NC_012967.1 similar to b0735; hypothetical protein 755484 ybgE 8175548 ybgE Escherichia coli B str. REL606 hypothetical protein YP_003043913.1 755191 D 413997 CDS YP_003043914.1 254160806 8175549 755634..756038 1 NC_012967.1 catalyzes the hydrolysis of short chain aliphatic acyl-CoA thioesters; physiological role remains unknown; involved in phospholipid metabolism; part of the Tol/Pal system of proteins that are critical for maintaining the integrity of the cell envelope components; acyl-CoA thioester hydrolase YbgC 756038 ybgC 8175549 ybgC Escherichia coli B str. REL606 acyl-CoA thioester hydrolase YbgC YP_003043914.1 755634 D 413997 CDS YP_003043915.1 254160807 8175550 756035..756727 1 NC_012967.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolQ 756727 tolQ 8175550 tolQ Escherichia coli B str. REL606 colicin uptake protein TolQ YP_003043915.1 756035 D 413997 CDS YP_003043916.1 254160808 8175551 756731..757159 1 NC_012967.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolR 757159 tolR 8175551 tolR Escherichia coli B str. REL606 colicin uptake protein TolR YP_003043916.1 756731 D 413997 CDS YP_003043917.1 254160809 8178941 757224..758489 1 NC_012967.1 inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins; cell envelope integrity inner membrane protein TolA 758489 tolA 8178941 tolA Escherichia coli B str. REL606 cell envelope integrity inner membrane protein TolA YP_003043917.1 757224 D 413997 CDS YP_003043918.1 254160810 8175552 758622..759914 1 NC_012967.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA; translocation protein TolB 759914 tolB 8175552 tolB Escherichia coli B str. REL606 translocation protein TolB YP_003043918.1 758622 D 413997 CDS YP_003043919.1 254160811 8175553 759949..760470 1 NC_012967.1 similar to b0741; peptidoglycan-associated outer membrane lipoprotein 760470 pal 8175553 pal Escherichia coli B str. REL606 peptidoglycan-associated outer membrane lipoprotein YP_003043919.1 759949 D 413997 CDS YP_003043920.1 254160812 8178942 760480..761271 1 NC_012967.1 periplasmic protein that interacts with TolA; the tol-pal system is probably involved in maintaining cell envelope integrity; tol-pal system protein YbgF 761271 ybgF 8178942 ybgF Escherichia coli B str. REL606 tol-pal system protein YbgF YP_003043920.1 760480 D 413997 CDS YP_003043921.1 254160813 8175559 762714..763757 1 NC_012967.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 763757 nadA 8175559 nadA Escherichia coli B str. REL606 quinolinate synthetase YP_003043921.1 762714 D 413997 CDS YP_003043922.1 254160814 8178391 763795..764514 1 NC_012967.1 similar to b0751; putative nicotinamide mononucleotide transporter 764514 pnuC 8178391 pnuC Escherichia coli B str. REL606 putative nicotinamide mononucleotide transporter YP_003043922.1 763795 D 413997 CDS YP_003043923.1 254160815 8175560 complement(764511..765452) 1 NC_012967.1 involved in zinc efflux across the cytoplasmic membrane; zinc transporter ZitB 765452 ybgR 8175560 ybgR Escherichia coli B str. REL606 zinc transporter ZitB YP_003043923.1 764511 R 413997 CDS YP_003043924.1 254160816 8175561 complement(765566..765946) 1 NC_012967.1 similar to b0753; hypothetical protein 765946 ybgS 8175561 ybgS Escherichia coli B str. REL606 hypothetical protein YP_003043924.1 765566 R 413997 CDS YP_003043925.1 254160817 8175562 766262..767314 1 NC_012967.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 767314 aroG 8175562 aroG Escherichia coli B str. REL606 phospho-2-dehydro-3-deoxyheptonate aldolase YP_003043925.1 766262 D 413997 CDS YP_003043926.1 254160818 8175563 complement(767472..768224) 1 NC_012967.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 768224 gpmA 8175563 gpmA Escherichia coli B str. REL606 phosphoglyceromutase YP_003043926.1 767472 R 413997 CDS YP_003043927.1 254160819 8175564 complement(768426..769466) 1 NC_012967.1 catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose; aldose 1-epimerase 769466 galM 8175564 galM Escherichia coli B str. REL606 aldose 1-epimerase YP_003043927.1 768426 R 413997 CDS YP_003043928.1 254160820 8175565 complement(769460..770608) 1 NC_012967.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase 770608 galK 8175565 galK Escherichia coli B str. REL606 galactokinase YP_003043928.1 769460 R 413997 CDS YP_003043929.1 254160821 8175566 complement(770612..771658) 1 NC_012967.1 catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P; galactose-1-phosphate uridylyltransferase 771658 galT 8175566 galT Escherichia coli B str. REL606 galactose-1-phosphate uridylyltransferase YP_003043929.1 770612 R 413997 CDS YP_003043930.1 254160822 8175567 complement(771668..772684) 1 NC_012967.1 similar to b0759; UDP-galactose-4-epimerase 772684 galE 8175567 galE Escherichia coli B str. REL606 UDP-galactose-4-epimerase YP_003043930.1 771668 R 413997 CDS YP_003043931.1 254160823 8178943 complement(772945..774417) 1 NC_012967.1 contains 2 ATP-binding cassettes; involved in the transport of molybdenum; putative molybdenum transport ATP-binding protein ModF 774417 modF 8178943 modF Escherichia coli B str. REL606 putative molybdenum transport ATP-binding protein ModF YP_003043931.1 772945 R 413997 CDS YP_003043932.1 254160824 8175568 complement(774485..775273) 1 NC_012967.1 represses the modABCD operon and activates the moaABCD and napFDAGHBC operons; DNA-binding transcriptional regulator ModE 775273 modE 8175568 modE Escherichia coli B str. REL606 DNA-binding transcriptional regulator ModE YP_003043932.1 774485 R 413997 CDS YP_003043933.1 254160825 8175569 775402..775551 1 NC_012967.1 similar to b0762; hypothetical protein 775551 ybhT 8175569 ybhT Escherichia coli B str. REL606 hypothetical protein YP_003043933.1 775402 D 413997 CDS YP_003043934.1 254160826 8178944 775718..776491 1 NC_012967.1 with ModCB is involved in the high-affinity transport of molybdate; molybdate transporter periplasmic protein 776491 modA 8178944 modA Escherichia coli B str. REL606 molybdate transporter periplasmic protein YP_003043934.1 775718 D 413997 CDS YP_003043935.1 254160827 8175570 776491..777180 1 NC_012967.1 part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE; molybdate ABC transporter permease 777180 modB 8175570 modB Escherichia coli B str. REL606 molybdate ABC transporter permease YP_003043935.1 776491 D 413997 CDS YP_003043936.1 254160828 8175571 777183..778241 1 NC_012967.1 Part of the ABC transporter complex modABC involved in molybdenum import; molybdate transporter ATP-binding protein 778241 modC 8175571 modC Escherichia coli B str. REL606 molybdate transporter ATP-binding protein YP_003043936.1 777183 D 413997 CDS YP_003043937.1 254160829 8178945 complement(778242..779060) 1 NC_012967.1 YbhA; catalyzes the dephosphorylation of pyridoxal phosphate, fructose 1,6-bisphosphate, erythrose 4-phosphate and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; phosphotransferase activity observed when using monophosphates as phosphate donor; member of the haloacid dehalogenase-like hydrolases superfamily; phosphotransferase 779060 ybhA 8178945 ybhA Escherichia coli B str. REL606 phosphotransferase YP_003043937.1 778242 R 413997 CDS YP_003043938.1 254160830 8175572 779215..780210 1 NC_012967.1 catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate; 6-phosphogluconolactonase 780210 ybhE 8175572 ybhE Escherichia coli B str. REL606 6-phosphogluconolactonase YP_003043938.1 779215 D 413997 CDS YP_003043939.1 254160831 8175573 complement(780251..781267) 1 NC_012967.1 similar to b0768; putative DNA-binding transcriptional regulator 781267 ybhD 8175573 ybhD Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003043939.1 780251 R 413997 CDS YP_003043940.1 254160832 8178392 781388..782440 1 NC_012967.1 similar to b0769; hypothetical protein 782440 ybhH 8178392 ybhH Escherichia coli B str. REL606 hypothetical protein YP_003043940.1 781388 D 413997 CDS YP_003043941.1 254160833 8175574 782516..783949 1 NC_012967.1 similar to b0770; putative transporter 783949 ybhI 8175574 ybhI Escherichia coli B str. REL606 putative transporter YP_003043941.1 782516 D 413997 CDS YP_003043942.1 254160834 8175575 784132..786393 1 NC_012967.1 similar to b0771; hypothetical protein 786393 ybhJ 8175575 ybhJ Escherichia coli B str. REL606 hypothetical protein YP_003043942.1 784132 D 413997 CDS YP_003043943.1 254160835 8178393 complement(786534..787817) 1 NC_012967.1 outer membrane lipoprotein that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; YbhC localizes to the cellular poles; member of pectinesterase family; putative pectinesterase 787817 ybhC 8178393 ybhC Escherichia coli B str. REL606 putative pectinesterase YP_003043943.1 786534 R 413997 CDS YP_003043944.1 254160836 8175576 complement(787952..789022) 1 NC_012967.1 integrase 789022 8175576 ECB_00726 Escherichia coli B str. REL606 integrase YP_003043944.1 787952 R 413997 CDS YP_003043945.1 254160837 8175577 complement(789498..789782) 1 NC_012967.1 phage related protein 789782 8175577 ECB_00727 Escherichia coli B str. REL606 phage related protein YP_003043945.1 789498 R 413997 CDS YP_003043946.1 254160838 8175578 complement(789775..790113) 1 NC_012967.1 hypothetical protein 790113 8175578 ECB_00728 Escherichia coli B str. REL606 hypothetical protein YP_003043946.1 789775 R 413997 CDS YP_003043947.1 254160839 8175579 complement(790059..790430) 1 NC_012967.1 hypothetical protein 790430 8175579 ECB_00729 Escherichia coli B str. REL606 hypothetical protein YP_003043947.1 790059 R 413997 CDS YP_003043948.1 254160840 8175580 790244..790588 1 NC_012967.1 putative Rz1 lytic protein 790588 8175580 ECB_00730 Escherichia coli B str. REL606 putative Rz1 lytic protein YP_003043948.1 790244 D 413997 CDS YP_003043949.1 254160841 8175581 790569..790754 1 NC_012967.1 hypothetical protein 790754 8175581 ECB_00731 Escherichia coli B str. REL606 hypothetical protein YP_003043949.1 790569 D 413997 CDS YP_003043950.1 254160842 8175582 791455..792006 1 NC_012967.1 hypothetical protein 792006 8175582 ECB_00732 Escherichia coli B str. REL606 hypothetical protein YP_003043950.1 791455 D 413997 CDS YP_003043951.1 254160843 8178946 792009..793631 1 NC_012967.1 hypothetical protein 793631 8178946 ECB_00733 Escherichia coli B str. REL606 hypothetical protein YP_003043951.1 792009 D 413997 CDS YP_003043952.1 254160844 8175583 793631..794392 1 NC_012967.1 putative bacteriophage protein 794392 8175583 ECB_00734 Escherichia coli B str. REL606 putative bacteriophage protein YP_003043952.1 793631 D 413997 CDS YP_003043953.1 254160845 8175584 794442..794900 1 NC_012967.1 hypothetical protein 794900 8175584 ECB_00735 Escherichia coli B str. REL606 hypothetical protein YP_003043953.1 794442 D 413997 CDS YP_003043954.1 254160846 8178947 794897..795295 1 NC_012967.1 hypothetical protein 795295 8178947 ECB_00736 Escherichia coli B str. REL606 hypothetical protein YP_003043954.1 794897 D 413997 CDS YP_003043955.1 254160847 8175585 complement(795337..796329) 1 NC_012967.1 hypothetical protein 796329 8175585 ECB_00737 Escherichia coli B str. REL606 hypothetical protein YP_003043955.1 795337 R 413997 CDS YP_003043956.1 254160848 8175586 796755..798092 1 NC_012967.1 hypothetical protein 798092 8175586 ECB_00738 Escherichia coli B str. REL606 hypothetical protein YP_003043956.1 796755 D 413997 CDS YP_003043957.1 254160849 8175587 complement(798130..799275) 1 NC_012967.1 hypothetical protein 799275 8175587 ECB_00739 Escherichia coli B str. REL606 hypothetical protein YP_003043957.1 798130 R 413997 CDS YP_003043958.1 254160850 8178948 complement(800059..800535) 1 NC_012967.1 YbhB; similar to rat and human kinase inhibitory proteins; putative kinase inhibitor protein 800535 ybhB 8178948 ybhB Escherichia coli B str. REL606 putative kinase inhibitor protein YP_003043958.1 800059 R 413997 CDS YP_003043959.1 254160851 8175588 complement(800594..801883) 1 NC_012967.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine--8-amino-7-oxononanoate transaminase 801883 bioA 8175588 bioA Escherichia coli B str. REL606 adenosylmethionine--8-amino-7-oxononanoate transaminase YP_003043959.1 800594 R 413997 CDS YP_003043960.1 254160852 8175589 801970..803010 1 NC_012967.1 similar to b0775; biotin synthase 803010 bioB 8175589 bioB Escherichia coli B str. REL606 biotin synthase YP_003043960.1 801970 D 413997 CDS YP_003043961.1 254160853 8178394 803007..804161 1 NC_012967.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 804161 bioF 8178394 bioF Escherichia coli B str. REL606 8-amino-7-oxononanoate synthase YP_003043961.1 803007 D 413997 CDS YP_003043962.1 254160854 8175590 804148..804903 1 NC_012967.1 putative methyltransferase; acyl carrier protein involved in an unidentified step in the synthesis of pimeloyl-CoA, a biotin precursor; member of the bio operon (bioABFCD); in Escherichia coli, bioC-null mutants require biotin for growth; biotin biosynthesis protein BioC 804903 bioC 8175590 bioC Escherichia coli B str. REL606 biotin biosynthesis protein BioC YP_003043962.1 804148 D 413997 CDS YP_003043963.1 254160855 8175591 804896..805573 1 NC_012967.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 805573 bioD 8175591 bioD Escherichia coli B str. REL606 dithiobiotin synthetase YP_003043963.1 804896 D 413997 CDS YP_003043964.1 254160856 8178395 806152..808173 1 NC_012967.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 808173 uvrB 8178395 uvrB Escherichia coli B str. REL606 excinuclease ABC subunit B YP_003043964.1 806152 D 413997 CDS YP_003043965.1 254160857 8175592 complement(808365..809273) 1 NC_012967.1 similar to b0780; putative transferase with NAD(P)-binding Rossmann-fold domain 809273 ybhK 8175592 ybhK Escherichia coli B str. REL606 putative transferase with NAD(P)-binding Rossmann-fold domain YP_003043965.1 808365 R 413997 CDS YP_003043966.1 254160858 8175593 809670..810659 1 NC_012967.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; molybdenum cofactor biosynthesis protein A 810659 moaA 8175593 moaA Escherichia coli B str. REL606 molybdenum cofactor biosynthesis protein A YP_003043966.1 809670 D 413997 CDS YP_003043967.1 254160859 8178396 810681..811193 1 NC_012967.1 similar to b0782; molybdopterin biosynthesis protein B 811193 moaB 8178396 moaB Escherichia coli B str. REL606 molybdopterin biosynthesis protein B YP_003043967.1 810681 D 413997 CDS YP_003043968.1 254160860 8175594 811196..811681 1 NC_012967.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC 811681 moaC 8175594 moaC Escherichia coli B str. REL606 molybdenum cofactor biosynthesis protein MoaC YP_003043968.1 811196 D 413997 CDS YP_003043969.1 254160861 8175595 811674..811919 1 NC_012967.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin synthase small subunit 811919 moaD 8175595 moaD Escherichia coli B str. REL606 molybdopterin synthase small subunit YP_003043969.1 811674 D 413997 CDS YP_003043970.1 254160862 8175596 811921..812373 1 NC_012967.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin guanine dinucleotide biosynthesis protein MoaE 812373 moaE 8175596 moaE Escherichia coli B str. REL606 molybdopterin guanine dinucleotide biosynthesis protein MoaE YP_003043970.1 811921 D 413997 CDS YP_003043971.1 254160863 8175597 812509..813213 1 NC_012967.1 similar to b0786; putative inner membrane protein 813213 ybhL 8175597 ybhL Escherichia coli B str. REL606 putative inner membrane protein YP_003043971.1 812509 D 413997 CDS YP_003043972.1 254160864 8175598 813418..814131 1 NC_012967.1 similar to b0787; inner membrane protein 814131 ybhM 8175598 ybhM Escherichia coli B str. REL606 inner membrane protein YP_003043972.1 813418 D 413997 CDS YP_003043973.1 254160865 8175599 complement(814167..815123) 1 NC_012967.1 similar to b0788; inner membrane protein 815123 ybhN 8175599 ybhN Escherichia coli B str. REL606 inner membrane protein YP_003043973.1 814167 R 413997 CDS YP_003043974.1 254160866 8175600 complement(815123..816364) 1 NC_012967.1 similar to b0789; cardiolipin synthase 2 816364 ybhO 8175600 ybhO Escherichia coli B str. REL606 cardiolipin synthase 2 YP_003043974.1 815123 R 413997 CDS YP_003043975.1 254160867 8178949 complement(816361..817122) 1 NC_012967.1 similar to b0790; putative DNase 817122 ybhP 8178949 ybhP Escherichia coli B str. REL606 putative DNase YP_003043975.1 816361 R 413997 CDS YP_003043976.1 254160868 8175601 817255..817665 1 NC_012967.1 similar to b0791; putative inner membrane protein 817665 ybhQ 8175601 ybhQ Escherichia coli B str. REL606 putative inner membrane protein YP_003043976.1 817255 D 413997 CDS YP_003043977.1 254160869 8175602 complement(817627..818733) 1 NC_012967.1 similar to b0792; putative transporter subunit membrane component of ABC superfamily 818733 ybhR 8175602 ybhR Escherichia coli B str. REL606 putative transporter subunit membrane component of ABC superfamily YP_003043977.1 817627 R 413997 CDS YP_003043978.1 254160870 8178950 complement(818744..819877) 1 NC_012967.1 similar to b0793; putative transporter subunit membrane component of ABC superfamily 819877 ybhS 8178950 ybhS Escherichia coli B str. REL606 putative transporter subunit membrane component of ABC superfamily YP_003043978.1 818744 R 413997 CDS YP_003043979.1 254160871 8175603 complement(819870..821606) 1 NC_012967.1 similar to b0794; ABC transporter ATP-binding protein 821606 ybhF 8175603 ybhF Escherichia coli B str. REL606 ABC transporter ATP-binding protein YP_003043979.1 819870 R 413997 CDS YP_003043980.1 254160872 8175604 complement(821599..822597) 1 NC_012967.1 similar to b0795; hypothetical protein 822597 ybhG 8175604 ybhG Escherichia coli B str. REL606 hypothetical protein YP_003043980.1 821599 R 413997 CDS YP_003043981.1 254160873 8175605 complement(822597..823268) 1 NC_012967.1 similar to b0796; putative DNA-binding transcriptional regulator 823268 ybiH 8175605 ybiH Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003043981.1 822597 R 413997 CDS YP_003043982.1 254160874 8175606 823497..824861 1 NC_012967.1 this helicase is not essential cell growth; ATP-dependent RNA helicase RhlE 824861 rhlE 8175606 rhlE Escherichia coli B str. REL606 ATP-dependent RNA helicase RhlE YP_003043982.1 823497 D 413997 CDS YP_003043983.1 254160875 8178397 complement(825093..825575) 1 NC_012967.1 similar to b0798; hypothetical protein 825575 ybiA 8178397 ybiA Escherichia coli B str. REL606 hypothetical protein YP_003043983.1 825093 R 413997 CDS YP_003043984.1 254160876 8175607 825695..827845 1 NC_012967.1 helicase involved in DNA repair and perhaps also replication; ATP-dependent DNA helicase DinG 827845 dinG 8175607 dinG Escherichia coli B str. REL606 ATP-dependent DNA helicase DinG YP_003043984.1 825695 D 413997 CDS YP_003043985.1 254160877 8175608 827873..828835 1 NC_012967.1 similar to b0800; glycosyl transferase family protein 828835 ybiB 8175608 ybiB Escherichia coli B str. REL606 glycosyl transferase family protein YP_003043985.1 827873 D 413997 CDS YP_003043986.1 254160878 8178398 828976..830061 1 NC_012967.1 similar to b0801; hypothetical protein 830061 ybiC 8178398 ybiC Escherichia coli B str. REL606 hypothetical protein YP_003043986.1 828976 D 413997 CDS YP_003043987.1 254160879 8175609 complement(830290..830550) 1 NC_012967.1 similar to b0802; hypothetical protein 830550 ybiJ 8175609 ybiJ Escherichia coli B str. REL606 hypothetical protein YP_003043987.1 830290 R 413997 CDS YP_003043988.1 254160880 8175610 complement(830815..831081) 1 NC_012967.1 similar to b0803; hypothetical protein 831081 ybiI 8175610 ybiI Escherichia coli B str. REL606 hypothetical protein YP_003043988.1 830815 R 413997 CDS YP_003043989.1 254160881 8175611 complement(831155..831832) 1 NC_012967.1 similar to b0804; putative hydroxylase 831832 ybiX 8175611 ybiX Escherichia coli B str. REL606 putative hydroxylase YP_003043989.1 831155 R 413997 CDS YP_003043990.1 254160882 8175612 complement(831874..834156) 1 NC_012967.1 Fiu; YbiL; porin involved in the uptake of iron complexed with catecholate siderophores (e.g. dihydroxybenzoylserine, dihydroxybenzoate) and beta lactam agents; Fiu interacts with TonB which provides the energy required for transport across the outer membrane; acts as a receptor for iron-siderophores and microcins E492, M, and H47; outer membrane protein; catecholate siderophore receptor Fiu 834156 ybiL 8175612 ybiL Escherichia coli B str. REL606 catecholate siderophore receptor Fiu YP_003043990.1 831874 R 413997 CDS YP_003043991.1 254160883 8175613 complement(834421..834681) 1 NC_012967.1 similar to b0806; hypothetical protein 834681 ybiM 8175613 ybiM Escherichia coli B str. REL606 hypothetical protein YP_003043991.1 834421 R 413997 CDS YP_003043992.1 254160884 8175614 834957..835883 1 NC_012967.1 similar to b0807; putative SAM-dependent methyltransferase 835883 ybiN 8175614 ybiN Escherichia coli B str. REL606 putative SAM-dependent methyltransferase YP_003043992.1 834957 D 413997 CDS YP_003043993.1 254160885 8178951 complement(835880..838105) 1 NC_012967.1 similar to b0808; hypothetical protein 838105 ybiO 8178951 ybiO Escherichia coli B str. REL606 hypothetical protein YP_003043993.1 835880 R 413997 CDS YP_003043994.1 254160886 8178952 complement(838366..839088) 1 NC_012967.1 similar to ATP-binding component of ABC transporters; glutamine ABC transporter ATP-binding protein 839088 glnQ 8178952 glnQ Escherichia coli B str. REL606 glutamine ABC transporter ATP-binding protein YP_003043994.1 838366 R 413997 CDS YP_003043995.1 254160887 8175615 complement(839085..839744) 1 NC_012967.1 similar to permease component of ABC transporters; mutations impair ability of Escherichia coli to transport and utilize glutamine; glutamine ABC transporter permease 839744 glnP 8175615 glnP Escherichia coli B str. REL606 glutamine ABC transporter permease YP_003043995.1 839085 R 413997 CDS YP_003043996.1 254160888 8178953 complement(839883..840629) 1 NC_012967.1 similar to periplasmic-binding component of ABC transporters; glutamine ABC transporter periplasmic protein 840629 glnH 8178953 glnH Escherichia coli B str. REL606 glutamine ABC transporter periplasmic protein YP_003043996.1 839883 R 413997 CDS YP_003043997.1 254160889 8175616 complement(841033..841536) 1 NC_012967.1 DNA protection protein during starvation conditions; binds DNA in a non-sequence-specific manner and is abundant during stationary phase; forms a DNA-protein crystal that protects DNA from damage; required for normal starvation response and long-term stationary viability; forms a homododecameric complex and sequesters iron which provides protection against oxidative damage; DNA starvation/stationary phase protection protein Dps 841536 dps 8175616 dps Escherichia coli B str. REL606 DNA starvation/stationary phase protection protein Dps YP_003043997.1 841033 R 413997 CDS YP_003043998.1 254160890 8175617 complement(841835..842722) 1 NC_012967.1 similar to b0813; threonine and homoserine efflux system 842722 ybiF 8175617 ybiF Escherichia coli B str. REL606 threonine and homoserine efflux system YP_003043998.1 841835 R 413997 CDS YP_003043999.1 254160891 8175618 843075..843590 1 NC_012967.1 OmpX; involved in cell adhesion; forms an eight-stranded antiparallel beta-barrel that protrudes from the cell surface; mutations in the gene increase cell-surface contact in fimbriated strains but decrease contact in nonfimbriated strains; outer membrane protein X 843590 ompX 8175618 ompX Escherichia coli B str. REL606 outer membrane protein X YP_003043999.1 843075 D 413997 CDS YP_003044000.1 254160892 8175619 complement(843639..845222) 1 NC_012967.1 similar to b0815; putative hydrolase, inner membrane 845222 ybiP 8175619 ybiP Escherichia coli B str. REL606 putative hydrolase, inner membrane YP_003044000.1 843639 R 413997 CDS YP_003044001.1 254160893 8175620 845296..845565 1 NC_012967.1 similar to b0816; hypothetical protein 845565 8175620 ECB_00783 Escherichia coli B str. REL606 hypothetical protein YP_003044001.1 845296 D 413997 CDS YP_003044002.1 254160894 8175621 845808..846275 1 NC_012967.1 Transcriptional regulator that represses the manganese transporter MntH when manganese is present; manganese transport regulator MntR 846275 mntR 8175621 mntR Escherichia coli B str. REL606 manganese transport regulator MntR YP_003044002.1 845808 D 413997 CDS YP_003044003.1 254160895 8178399 846272..847390 1 NC_012967.1 similar to b0818; putative transporter 847390 ybiR 8178399 ybiR Escherichia coli B str. REL606 putative transporter YP_003044003.1 846272 D 413997 CDS YP_003044004.1 254160896 8175622 complement(847449..848369) 1 NC_012967.1 similar to b0819; hypothetical protein 848369 ybiS 8175622 ybiS Escherichia coli B str. REL606 hypothetical protein YP_003044004.1 847449 R 413997 CDS YP_003044005.1 254160897 8175623 848588..850180 1 NC_012967.1 similar to b0820; ABC transporter ATP-binding protein 850180 ybiT 8175623 ybiT Escherichia coli B str. REL606 ABC transporter ATP-binding protein YP_003044005.1 848588 D 413997 CDS YP_003044006.1 254160898 8178400 complement(850348..851613) 1 NC_012967.1 similar to b0821; hypothetical protein 851613 ybiU 8178400 ybiU Escherichia coli B str. REL606 hypothetical protein YP_003044006.1 850348 R 413997 CDS YP_003044007.1 254160899 8175624 complement(851765..852580) 1 NC_012967.1 similar to b0822; putative hydrolase 852580 ybiV 8175624 ybiV Escherichia coli B str. REL606 putative hydrolase YP_003044007.1 851765 R 413997 CDS YP_003044008.1 254160900 8175625 complement(852726..855158) 1 NC_012967.1 similar to b0823; putative pyruvate formate lyase 855158 ybiW 8175625 ybiW Escherichia coli B str. REL606 putative pyruvate formate lyase YP_003044008.1 852726 R 413997 CDS YP_003044009.1 254160901 8175626 complement(855164..856090) 1 NC_012967.1 similar to b0824; putative pyruvate formate lyase activating enzyme 856090 ybiY 8175626 ybiY Escherichia coli B str. REL606 putative pyruvate formate lyase activating enzyme YP_003044009.1 855164 R 413997 CDS YP_003044010.1 254160902 8175627 856194..856856 1 NC_012967.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 856856 fsa 8175627 fsa Escherichia coli B str. REL606 fructose-6-phosphate aldolase YP_003044010.1 856194 D 413997 CDS YP_003044011.1 254160903 8175628 complement(856932..857681) 1 NC_012967.1 ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase; molybdopterin biosynthesis protein MoeB 857681 moeB 8175628 moeB Escherichia coli B str. REL606 molybdopterin biosynthesis protein MoeB YP_003044011.1 856932 R 413997 CDS YP_003044012.1 254160904 8175629 complement(857681..858916) 1 NC_012967.1 is involved in the formation of active molybdenum cofactor and the chelation of molybdenum; molybdopterin biosynthesis protein MoeA 858916 moeA 8175629 moeA Escherichia coli B str. REL606 molybdopterin biosynthesis protein MoeA YP_003044012.1 857681 R 413997 CDS YP_003044013.1 254160905 8178954 859120..860085 1 NC_012967.1 similar to b0828; L-asparaginase 860085 ybiK 8178954 ybiK Escherichia coli B str. REL606 L-asparaginase YP_003044013.1 859120 D 413997 CDS YP_003044014.1 254160906 8178955 860105..861943 1 NC_012967.1 with GsiBCD is involved in glutathione import; GsiA contains 2 ATP-binding domains; glutathione transporter ATP-binding protein 861943 yliA 8178955 yliA Escherichia coli B str. REL606 glutathione transporter ATP-binding protein YP_003044014.1 860105 D 413997 CDS YP_003044015.1 254160907 8175630 862020..863501 1 NC_012967.1 similar to b0830; putative peptide transporter subunit periplasmic-binding component of ABC superfamily 863501 yliB 8175630 yliB Escherichia coli B str. REL606 putative peptide transporter subunit periplasmic-binding component of ABC superfamily YP_003044015.1 862020 D 413997 CDS YP_003044016.1 254160908 8178956 863519..864439 1 NC_012967.1 similar to b0831; putative peptide transporter subunit membrane component of ABC superfamily 864439 yliC 8178956 yliC Escherichia coli B str. REL606 putative peptide transporter subunit membrane component of ABC superfamily YP_003044016.1 863519 D 413997 CDS YP_003044017.1 254160909 8175631 864442..865353 1 NC_012967.1 similar to b0832; putative peptide transporter subunit membrane component of ABC superfamily 865353 yliD 8175631 yliD Escherichia coli B str. REL606 putative peptide transporter subunit membrane component of ABC superfamily YP_003044017.1 864442 D 413997 CDS YP_003044018.1 254160910 8175632 865783..867879 1 NC_012967.1 similar to b0833; inner membrane protein 867879 yliE 8175632 yliE Escherichia coli B str. REL606 inner membrane protein YP_003044018.1 865783 D 413997 CDS YP_003044019.1 254160911 8175633 867887..869215 1 NC_012967.1 similar to b0834; putative diguanylate cyclase 869215 yliF 8175633 yliF Escherichia coli B str. REL606 putative diguanylate cyclase YP_003044019.1 867887 D 413997 CDS YP_003044020.1 254160912 8175634 complement(869262..870587) 1 NC_012967.1 catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit; ribosomal protein S12 methylthiotransferase 870587 rimO 8175634 rimO Escherichia coli B str. REL606 ribosomal protein S12 methylthiotransferase YP_003044020.1 869262 R 413997 CDS YP_003044021.1 254160913 8175635 870800..871183 1 NC_012967.1 BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing; biofilm formation regulatory protein BssR 871183 bssR 8175635 bssR Escherichia coli B str. REL606 biofilm formation regulatory protein BssR YP_003044021.1 870800 D 413997 CDS YP_003044022.1 254160914 8175636 871294..872409 1 NC_012967.1 similar to b0837; putative dehydrogenase 872409 yliI 8175636 yliI Escherichia coli B str. REL606 putative dehydrogenase YP_003044022.1 871294 D 413997 CDS YP_003044023.1 254160915 8178401 complement(872406..873032) 1 NC_012967.1 similar to b0838; putative glutathione S-transferase 873032 yliJ 8178401 yliJ Escherichia coli B str. REL606 putative glutathione S-transferase YP_003044023.1 872406 R 413997 CDS YP_003044024.1 254160916 8175637 873279..874481 1 NC_012967.1 penicillin-binding protein 6a; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase fraction C 874481 dacC 8175637 dacC Escherichia coli B str. REL606 D-alanyl-D-alanine carboxypeptidase fraction C YP_003044024.1 873279 D 413997 CDS YP_003044025.1 254160917 8178402 complement(874528..875286) 1 NC_012967.1 similar to b0840; DNA-binding transcriptional repressor DeoR 875286 deoR 8178402 deoR Escherichia coli B str. REL606 DNA-binding transcriptional repressor DeoR YP_003044025.1 874528 R 413997 CDS YP_003044026.1 254160918 8178403 complement(875344..875940) 1 NC_012967.1 similar to b0841; undecaprenyl pyrophosphate phosphatase 875940 ybjG 8178403 ybjG Escherichia coli B str. REL606 undecaprenyl pyrophosphate phosphatase YP_003044026.1 875344 R 413997 CDS YP_003044027.1 254160919 8175638 876225..877457 1 NC_012967.1 similar to b0842; multidrug efflux system protein 877457 cmr 8175638 cmr Escherichia coli B str. REL606 multidrug efflux system protein YP_003044027.1 876225 D 413997 CDS YP_003044028.1 254160920 8175639 complement(877498..877782) 1 NC_012967.1 similar to b0843; hypothetical protein 877782 ybjH 8175639 ybjH Escherichia coli B str. REL606 hypothetical protein YP_003044028.1 877498 R 413997 CDS YP_003044029.1 254160921 8175640 complement(877868..878683) 1 NC_012967.1 similar to b0844; hypothetical protein 878683 ybjI 8175640 ybjI Escherichia coli B str. REL606 hypothetical protein YP_003044029.1 877868 R 413997 CDS YP_003044030.1 254160922 8175641 complement(878683..879891) 1 NC_012967.1 similar to b0845; putative transporter 879891 ybjJ 8175641 ybjJ Escherichia coli B str. REL606 putative transporter YP_003044030.1 878683 R 413997 CDS YP_003044031.1 254160923 8175642 879975..880511 1 NC_012967.1 similar to b0846; putative DNA-binding transcriptional regulator 880511 ybjK 8175642 ybjK Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003044031.1 879975 D 413997 CDS YP_003044032.1 254160924 8175643 complement(880691..881023) 1 NC_012967.1 hypothetical protein 881023 8175643 ECB_00814 Escherichia coli B str. REL606 hypothetical protein YP_003044032.1 880691 R 413997 CDS YP_003044033.1 254160925 8178957 complement(881132..882076) 1 NC_012967.1 integrase for prophage 882076 8178957 ECB_00815 Escherichia coli B str. REL606 integrase for prophage YP_003044033.1 881132 R 413997 CDS YP_003044034.1 254160926 8175644 complement(882310..882462) 1 NC_012967.1 hypothetical protein 882462 8175644 ECB_00816 Escherichia coli B str. REL606 hypothetical protein YP_003044034.1 882310 R 413997 CDS YP_003044035.1 254160927 8175645 complement(882542..883105) 1 NC_012967.1 Repressor protein 883105 8175645 ECB_00817 Escherichia coli B str. REL606 Repressor protein YP_003044035.1 882542 R 413997 CDS YP_003044036.1 254160928 8178958 883237..883458 1 NC_012967.1 hypothetical protein 883458 8178958 ECB_00818 Escherichia coli B str. REL606 hypothetical protein YP_003044036.1 883237 D 413997 CDS YP_003044037.1 254160929 8175646 883491..884000 1 NC_012967.1 hypothetical protein 884000 8175646 ECB_00819 Escherichia coli B str. REL606 hypothetical protein YP_003044037.1 883491 D 413997 CDS YP_003044038.1 254160930 8175647 883969..884208 1 NC_012967.1 hypothetical protein 884208 8175647 ECB_00820 Escherichia coli B str. REL606 hypothetical protein YP_003044038.1 883969 D 413997 CDS YP_003044039.1 254160931 8175648 884172..884513 1 NC_012967.1 hypothetical protein 884513 8175648 ECB_00821 Escherichia coli B str. REL606 hypothetical protein YP_003044039.1 884172 D 413997 CDS YP_003044040.1 254160932 8175649 884581..884814 1 NC_012967.1 hypothetical protein 884814 8175649 ECB_00822 Escherichia coli B str. REL606 hypothetical protein YP_003044040.1 884581 D 413997 CDS YP_003044041.1 254160933 8175650 884814..885041 1 NC_012967.1 hypothetical protein 885041 8175650 ECB_00823 Escherichia coli B str. REL606 hypothetical protein YP_003044041.1 884814 D 413997 CDS YP_003044042.1 254160934 8175651 885038..885895 1 NC_012967.1 retron adenine methylase-like protein 885895 8175651 ECB_00824 Escherichia coli B str. REL606 retron adenine methylase-like protein YP_003044042.1 885038 D 413997 CDS YP_003044043.1 254160935 8178404 885892..888306 1 NC_012967.1 putative replication protein for prophage 888306 8178404 ECB_00825 Escherichia coli B str. REL606 putative replication protein for prophage YP_003044043.1 885892 D 413997 CDS YP_003044044.1 254160936 8175652 888459..888647 1 NC_012967.1 hypothetical protein 888647 8175652 ECB_00826 Escherichia coli B str. REL606 hypothetical protein YP_003044044.1 888459 D 413997 CDS YP_003044045.1 254160937 8178405 888586..888891 1 NC_012967.1 Prophage protein 888891 8178405 ECB_00827 Escherichia coli B str. REL606 Prophage protein YP_003044045.1 888586 D 413997 CDS YP_003044046.1 254160938 8178406 complement(889084..889419) 1 NC_012967.1 hypothetical protein 889419 8178406 ECB_00828 Escherichia coli B str. REL606 hypothetical protein YP_003044046.1 889084 R 413997 CDS YP_003044047.1 254160939 8175653 889691..889855 1 NC_012967.1 hypothetical protein 889855 8175653 ECB_00829 Escherichia coli B str. REL606 hypothetical protein YP_003044047.1 889691 D 413997 CDS YP_003044048.1 254160940 8175654 889892..890815 1 NC_012967.1 hypothetical protein 890815 8175654 ECB_00830 Escherichia coli B str. REL606 hypothetical protein YP_003044048.1 889892 D 413997 CDS YP_003044049.1 254160941 8175655 890978..891940 1 NC_012967.1 retron DNA polymerase-like protein 891940 8175655 ECB_00831 Escherichia coli B str. REL606 retron DNA polymerase-like protein YP_003044049.1 890978 D 413997 CDS YP_003044050.1 254160942 8175656 complement(891958..892986) 1 NC_012967.1 putative capsid portal protein 892986 8175656 ECB_00832 Escherichia coli B str. REL606 putative capsid portal protein YP_003044050.1 891958 R 413997 CDS YP_003044051.1 254160943 8175657 complement(892983..894749) 1 NC_012967.1 Terminase, ATPase subunit 894749 8175657 ECB_00833 Escherichia coli B str. REL606 Terminase, ATPase subunit YP_003044051.1 892983 R 413997 CDS YP_003044052.1 254160944 8175658 894892..895644 1 NC_012967.1 putative capsid scaffolding protein 895644 8175658 ECB_00834 Escherichia coli B str. REL606 putative capsid scaffolding protein YP_003044052.1 894892 D 413997 CDS YP_003044053.1 254160945 8178959 895638..895784 1 NC_012967.1 hypothetical protein 895784 8178959 ECB_00835 Escherichia coli B str. REL606 hypothetical protein YP_003044053.1 895638 D 413997 CDS YP_003044054.1 254160946 8175659 895781..896209 1 NC_012967.1 putative Regulatory protein 896209 8175659 ECB_00836 Escherichia coli B str. REL606 putative Regulatory protein YP_003044054.1 895781 D 413997 CDS YP_003044055.1 254160947 8175660 896052..896342 1 NC_012967.1 Fels-2 prophage protein 896342 8175660 ECB_00837 Escherichia coli B str. REL606 Fels-2 prophage protein YP_003044055.1 896052 D 413997 CDS YP_003044056.1 254160948 8178960 896305..896736 1 NC_012967.1 putative phage tail protein 896736 8178960 ECB_00838 Escherichia coli B str. REL606 putative phage tail protein YP_003044056.1 896305 D 413997 CDS YP_003044057.1 254160949 8175661 896729..897175 1 NC_012967.1 putative phage tail protein 897175 8175661 ECB_00839 Escherichia coli B str. REL606 putative phage tail protein YP_003044057.1 896729 D 413997 CDS YP_003044058.1 254160950 8175662 complement(897117..897923) 1 NC_012967.1 hypothetical protein 897923 8175662 ECB_00840 Escherichia coli B str. REL606 hypothetical protein YP_003044058.1 897117 R 413997 CDS YP_003044059.1 254160951 8175663 897784..898605 1 NC_012967.1 hypothetical protein 898605 8175663 ECB_00841 Escherichia coli B str. REL606 hypothetical protein YP_003044059.1 897784 D 413997 CDS YP_003044060.1 254160952 8175664 898602..898961 1 NC_012967.1 phage baseplate assembly protein 898961 8175664 ECB_00842 Escherichia coli B str. REL606 phage baseplate assembly protein YP_003044060.1 898602 D 413997 CDS YP_003044061.1 254160953 8175665 898948..899856 1 NC_012967.1 phage baseplate assembly protein 899856 8175665 ECB_00843 Escherichia coli B str. REL606 phage baseplate assembly protein YP_003044061.1 898948 D 413997 CDS YP_003044062.1 254160954 8175666 899849..900454 1 NC_012967.1 putative phage tail protein 900454 8175666 ECB_00844 Escherichia coli B str. REL606 putative phage tail protein YP_003044062.1 899849 D 413997 CDS YP_003044063.1 254160955 8175667 900451..902073 1 NC_012967.1 hypothetical protein 902073 8175667 ECB_00845 Escherichia coli B str. REL606 hypothetical protein YP_003044063.1 900451 D 413997 CDS YP_003044064.1 254160956 8178407 902075..902512 1 NC_012967.1 hypothetical protein 902512 8178407 ECB_00846 Escherichia coli B str. REL606 hypothetical protein YP_003044064.1 902075 D 413997 CDS YP_003044065.1 254160957 8175668 complement(902484..903086) 1 NC_012967.1 similar to b1156; e14 prophage; putative tail fiber assembly protein 903086 tfaE 8175668 tfaE Escherichia coli B str. REL606 e14 prophage; putative tail fiber assembly protein YP_003044065.1 902484 R 413997 CDS YP_003044066.1 254160958 8178961 complement(903086..903625) 1 NC_012967.1 bacteriophage tail fiber protein 903625 8178961 ECB_00848 Escherichia coli B str. REL606 bacteriophage tail fiber protein YP_003044066.1 903086 R 413997 CDS YP_003044067.1 254160959 8175669 903656..903931 1 NC_012967.1 putative DNA-invertase 903931 8175669 ECB_00849 Escherichia coli B str. REL606 putative DNA-invertase YP_003044067.1 903656 D 413997 CDS YP_003044068.1 254160960 8175670 903928..904296 1 NC_012967.1 putative regulator of late gene expression 904296 8175670 ECB_00850 Escherichia coli B str. REL606 putative regulator of late gene expression YP_003044068.1 903928 D 413997 CDS YP_003044069.1 254160961 8175671 904354..904605 1 NC_012967.1 prophage P2 OGR-like protein 904605 8175671 ECB_00851 Escherichia coli B str. REL606 prophage P2 OGR-like protein YP_003044069.1 904354 D 413997 CDS YP_003044070.1 254160962 8175672 complement(904841..906526) 1 NC_012967.1 similar to b0847; hypothetical protein 906526 ybjL 8175672 ybjL Escherichia coli B str. REL606 hypothetical protein YP_003044070.1 904841 R 413997 CDS YP_003044071.1 254160963 8175673 906796..907173 1 NC_012967.1 similar to b0848; putative inner membrane protein 907173 ybjM 8175673 ybjM Escherichia coli B str. REL606 putative inner membrane protein YP_003044071.1 906796 D 413997 CDS YP_003044072.1 254160964 8175674 complement(907203..907460) 1 NC_012967.1 functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase; glutaredoxin 1 907460 grxA 8175674 grxA Escherichia coli B str. REL606 glutaredoxin 1 YP_003044072.1 907203 R 413997 CDS YP_003044073.1 254160965 8175675 907620..907907 1 NC_012967.1 YbjC; located in the same operon as the nfsA gene; member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress; induced by paraquat; regulated by SoxS; unknown function; hypothetical protein 907907 ybjC 8175675 ybjC Escherichia coli B str. REL606 hypothetical protein YP_003044073.1 907620 D 413997 CDS YP_003044074.1 254160966 8175676 907891..908613 1 NC_012967.1 NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds; nitroreductase A 908613 nfsA 8175676 nfsA Escherichia coli B str. REL606 nitroreductase A YP_003044074.1 907891 D 413997 CDS YP_003044075.1 254160967 8175677 908674..909576 1 NC_012967.1 responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6; ribosomal protein S6 modification protein 909576 rimK 8175677 rimK Escherichia coli B str. REL606 ribosomal protein S6 modification protein YP_003044075.1 908674 D 413997 CDS YP_003044076.1 254160968 8175678 909664..910140 1 NC_012967.1 similar to b0853; putative oxidoreductase 910140 ybjN 8175678 ybjN Escherichia coli B str. REL606 putative oxidoreductase YP_003044076.1 909664 D 413997 CDS YP_003044077.1 254160969 8175679 910491..911603 1 NC_012967.1 similar to b0854; putrescine transporter subunit periplasmic-binding component of ABC superfamily 911603 potF 8175679 potF Escherichia coli B str. REL606 putrescine transporter subunit periplasmic-binding component of ABC superfamily YP_003044077.1 910491 D 413997 CDS YP_003044078.1 254160970 8175680 911698..912831 1 NC_012967.1 part of the PotFGHI ATP-dependent putrescine transporter; putrescine transporter ATP-binding subunit 912831 potG 8175680 potG Escherichia coli B str. REL606 putrescine transporter ATP-binding subunit YP_003044078.1 911698 D 413997 CDS YP_003044079.1 254160971 8178408 912841..913794 1 NC_012967.1 similar to b0856; putrescine transporter subunit membrane component of ABC superfamily 913794 potH 8178408 potH Escherichia coli B str. REL606 putrescine transporter subunit membrane component of ABC superfamily YP_003044079.1 912841 D 413997 CDS YP_003044080.1 254160972 8175681 913791..914636 1 NC_012967.1 similar to b0857; putrescine transporter subunit membrane component of ABC superfamily 914636 potI 8175681 potI Escherichia coli B str. REL606 putrescine transporter subunit membrane component of ABC superfamily YP_003044080.1 913791 D 413997 CDS YP_003044081.1 254160973 8178962 914696..915184 1 NC_012967.1 similar to b0858; putative inner membrane protein 915184 ybjO 8178962 ybjO Escherichia coli B str. REL606 putative inner membrane protein YP_003044081.1 914696 D 413997 CDS YP_003044082.1 254160974 8175682 915225..916352 1 NC_012967.1 RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA; 23S rRNA methyluridine methyltransferase 916352 rumB 8175682 rumB Escherichia coli B str. REL606 23S rRNA methyluridine methyltransferase YP_003044082.1 915225 D 413997 CDS YP_003044083.1 254160975 8175683 complement(916551..917282) 1 NC_012967.1 similar to b0860; arginine transporter subunit 917282 artJ 8175683 artJ Escherichia coli B str. REL606 arginine transporter subunit YP_003044083.1 916551 R 413997 CDS YP_003044084.1 254160976 8175684 complement(917573..918241) 1 NC_012967.1 with ArtPQJI acts to transport arginine across the inner membrane; arginine transporter permease ArtM 918241 artM 8175684 artM Escherichia coli B str. REL606 arginine transporter permease ArtM YP_003044084.1 917573 R 413997 CDS YP_003044085.1 254160977 8175685 complement(918241..918957) 1 NC_012967.1 with ArtPMJI transports arginine across the inner membrane; arginine transporter permease ArtQ 918957 artQ 8175685 artQ Escherichia coli B str. REL606 arginine transporter permease ArtQ YP_003044085.1 918241 R 413997 CDS YP_003044086.1 254160978 8178963 complement(918964..919695) 1 NC_012967.1 similar to b0863; arginine transporter subunit 919695 artI 8178963 artI Escherichia coli B str. REL606 arginine transporter subunit YP_003044086.1 918964 R 413997 CDS YP_003044087.1 254160979 8178964 complement(919713..920441) 1 NC_012967.1 With ArtMQJI transports arginine across the inner membrane; arginine transporter ATP-binding subunit 920441 artP 8178964 artP Escherichia coli B str. REL606 arginine transporter ATP-binding subunit YP_003044087.1 919713 R 413997 CDS YP_003044088.1 254160980 8175686 complement(920659..921174) 1 NC_012967.1 induced during stationary phase and by acivicin (a glutamine analog); regulated by Lrp and RpoS; putative lipoprotein 921174 ybjP 8175686 ybjP Escherichia coli B str. REL606 putative lipoprotein YP_003044088.1 920659 R 413997 CDS YP_003044089.1 254160981 8178965 921300..921623 1 NC_012967.1 similar to b0866; hypothetical protein 921623 ybjQ 8178965 ybjQ Escherichia coli B str. REL606 hypothetical protein YP_003044089.1 921300 D 413997 CDS YP_003044090.1 254160982 8175687 921620..922450 1 NC_012967.1 similar to b0867; putative amidase and lipoprotein 922450 ybjR 8175687 ybjR Escherichia coli B str. REL606 putative amidase and lipoprotein YP_003044090.1 921620 D 413997 CDS YP_003044091.1 254160983 8175688 complement(922447..923460) 1 NC_012967.1 similar to b0868; putative NAD(P)H-binding oxidoreductase with NAD(P)-binding Rossmann-fold domain 923460 ybjS 8175688 ybjS Escherichia coli B str. REL606 putative NAD(P)H-binding oxidoreductase with NAD(P)-binding Rossmann-fold domain YP_003044091.1 922447 R 413997 CDS YP_003044092.1 254160984 8175689 complement(923559..924989) 1 NC_012967.1 similar to b0869; hypothetical protein 924989 ybjT 8175689 ybjT Escherichia coli B str. REL606 hypothetical protein YP_003044092.1 923559 R 413997 CDS YP_003044093.1 254160985 8175690 complement(925000..926001) 1 NC_012967.1 low- specificity; catalyzes the formation of acetaldehyde and glycine from L-threonine; acts on L-threonine, L-allo-threonine, L-threo-phenylserine, and L-erythro-phenylserine; L-threonine aldolase 926001 ltaE 8175690 ltaE Escherichia coli B str. REL606 L-threonine aldolase YP_003044093.1 925000 R 413997 CDS YP_003044094.1 254160986 8178966 complement(926038..927756) 1 NC_012967.1 catalyzes the formation of acetate from pyruvate; pyruvate dehydrogenase 927756 poxB 8178966 poxB Escherichia coli B str. REL606 pyruvate dehydrogenase YP_003044094.1 926038 R 413997 CDS YP_003044095.1 254160987 8175691 complement(927889..928857) 1 NC_012967.1 similar to b0872; HCP oxidoreductase, NADH-dependent 928857 hcr 8175691 hcr Escherichia coli B str. REL606 HCP oxidoreductase, NADH-dependent YP_003044095.1 927889 R 413997 CDS YP_003044096.1 254160988 8175692 complement(928869..930521) 1 NC_012967.1 catalyzes the reduction of hydroxylamine to ammonia and water; hydroxylamine reductase 930521 hcp 8175692 hcp Escherichia coli B str. REL606 hydroxylamine reductase YP_003044096.1 928869 R 413997 CDS YP_003044097.1 254160989 8175693 complement(930665..931564) 1 NC_012967.1 similar to b0874; putative transporter 931564 ybjE 8175693 ybjE Escherichia coli B str. REL606 putative transporter YP_003044097.1 930665 R 413997 CDS YP_003044098.1 254160990 8178409 complement(932059..932754) 1 NC_012967.1 porin involved in osmoregulation allowing water to move into and out of the cell in response to osmotic pressure; aquaporin Z 932754 aqpZ 8178409 aqpZ Escherichia coli B str. REL606 aquaporin Z YP_003044098.1 932059 R 413997 CDS YP_003044099.1 254160991 8178410 933179..934837 1 NC_012967.1 similar to b0876; hypothetical protein 934837 ybjD 8178410 ybjD Escherichia coli B str. REL606 hypothetical protein YP_003044099.1 933179 D 413997 CDS YP_003044100.1 254160992 8175694 complement(934834..935826) 1 NC_012967.1 similar to b0877; hypothetical protein 935826 ybjX 8175694 ybjX Escherichia coli B str. REL606 hypothetical protein YP_003044100.1 934834 R 413997 CDS YP_003044101.1 254160993 8175695 935941..937056 1 NC_012967.1 confers macrolide resistance via active drug efflux; macrolide transporter subunit MacA 937056 macA 8175695 macA Escherichia coli B str. REL606 macrolide transporter subunit MacA YP_003044101.1 935941 D 413997 CDS YP_003044102.1 254160994 8175696 937053..938999 1 NC_012967.1 with MacA is involved in the export of macrolide; macrolide transporter ATP-binding /permease 938999 macB 8175696 macB Escherichia coli B str. REL606 macrolide transporter ATP-binding /permease YP_003044102.1 937053 D 413997 CDS YP_003044103.1 254160995 8175697 complement(939072..939296) 1 NC_012967.1 inhibits DNA replication at both initiation and elongation steps; stationary phase and starvation inducible; stationary phase/starvation inducible regulatory protein CspD 939296 cspD 8175697 cspD Escherichia coli B str. REL606 stationary phase/starvation inducible regulatory protein CspD YP_003044103.1 939072 R 413997 CDS YP_003044104.1 254160996 8178967 939619..939939 1 NC_012967.1 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA; ATP-dependent Clp protease adaptor protein ClpS 939939 clpS 8178967 clpS Escherichia coli B str. REL606 ATP-dependent Clp protease adaptor protein ClpS YP_003044104.1 939619 D 413997 CDS YP_003044105.1 254160997 8175698 940113..942245 1 NC_012967.1 similar to b0882; ATPase and specificity subunit of ClpA-ClpP ATP-dependent serine protease, chaperone activity 942245 clpA 8175698 clpA Escherichia coli B str. REL606 ATPase and specificity subunit of ClpA-ClpP ATP-dependent serine protease, chaperone activity YP_003044105.1 940113 D 413997 CDS YP_003044106.1 254160998 8175700 complement(943283..943501) 1 NC_012967.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 943501 infA 8175700 infA Escherichia coli B str. REL606 translation initiation factor IF-1 YP_003044106.1 943283 R 413997 CDS YP_003044107.1 254160999 8178411 complement(943786..944490) 1 NC_012967.1 leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys; leucyl/phenylalanyl-tRNA--protein transferase 944490 aat 8178411 aat Escherichia coli B str. REL606 leucyl/phenylalanyl-tRNA--protein transferase YP_003044107.1 943786 R 413997 CDS YP_003044108.1 254161000 8178968 complement(944532..946253) 1 NC_012967.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein 946253 cydC 8178968 cydC Escherichia coli B str. REL606 cysteine/glutathione ABC transporter membrane/ATP-binding protein YP_003044108.1 944532 R 413997 CDS YP_003044109.1 254161001 8175701 complement(946254..948020) 1 NC_012967.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein 948020 cydD 8175701 cydD Escherichia coli B str. REL606 cysteine/glutathione ABC transporter membrane/ATP-binding protein YP_003044109.1 946254 R 413997 CDS YP_003044110.1 254161002 8175702 complement(948143..949108) 1 NC_012967.1 catalyzes the transfer of electrons from NADPH to thioredoxin; FAD/NAD(P) binding; thioredoxin reductase 949108 trxB 8175702 trxB Escherichia coli B str. REL606 thioredoxin reductase YP_003044110.1 948143 R 413997 CDS YP_003044111.1 254161003 8175703 949653..950147 1 NC_012967.1 mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system; leucine-responsive transcriptional regulator 950147 lrp 8175703 lrp Escherichia coli B str. REL606 leucine-responsive transcriptional regulator YP_003044111.1 949653 D 413997 CDS YP_003044112.1 254161004 8175704 950282..954310 1 NC_012967.1 DNA-binding membrane protein required for chromosome resolution and partitioning; DNA translocase FtsK 954310 ftsK 8175704 ftsK Escherichia coli B str. REL606 DNA translocase FtsK YP_003044112.1 950282 D 413997 CDS YP_003044113.1 254161005 8175705 954462..955076 1 NC_012967.1 participates with LolB in the incorporation of lipoprotein into the outer membrane; outer-membrane lipoprotein carrier protein 955076 lolA 8175705 lolA Escherichia coli B str. REL606 outer-membrane lipoprotein carrier protein YP_003044113.1 954462 D 413997 CDS YP_003044114.1 254161006 8175706 955087..956430 1 NC_012967.1 similar to b0892; recombination factor protein RarA 956430 ycaJ 8175706 ycaJ Escherichia coli B str. REL606 recombination factor protein RarA YP_003044114.1 955087 D 413997 CDS YP_003044115.1 254161007 8175707 956521..957813 1 NC_012967.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 957813 serS 8175707 serS Escherichia coli B str. REL606 seryl-tRNA synthetase YP_003044115.1 956521 D 413997 CDS YP_003044116.1 254161008 8175708 958052..960496 1 NC_012967.1 similar to b0894; dimethyl sulfoxide reductase, anaerobic, subunit A 960496 dmsA 8175708 dmsA Escherichia coli B str. REL606 dimethyl sulfoxide reductase, anaerobic, subunit A YP_003044116.1 958052 D 413997 CDS YP_003044117.1 254161009 8178412 960507..961124 1 NC_012967.1 similar to b0895; dimethyl sulfoxide reductase, anaerobic, subunit B 961124 dmsB 8178412 dmsB Escherichia coli B str. REL606 dimethyl sulfoxide reductase, anaerobic, subunit B YP_003044117.1 960507 D 413997 CDS YP_003044118.1 254161010 8178413 961126..961989 1 NC_012967.1 similar to b0896; dimethyl sulfoxide reductase, anaerobic, subunit C 961989 dmsC 8178413 dmsC Escherichia coli B str. REL606 dimethyl sulfoxide reductase, anaerobic, subunit C YP_003044118.1 961126 D 413997 CDS YP_003044119.1 254161011 8175709 complement(962024..962650) 1 NC_012967.1 similar to b0897; putative hydrolase 962650 ycaC 8175709 ycaC Escherichia coli B str. REL606 putative hydrolase YP_003044119.1 962024 R 413997 CDS YP_003044120.1 254161012 8175710 962964..964112 1 NC_012967.1 similar to b0898; putative MFS family transporter protein 964112 ycaD 8175710 ycaD Escherichia coli B str. REL606 putative MFS family transporter protein YP_003044120.1 962964 D 413997 CDS YP_003044121.1 254161013 8175711 964322..965752 1 NC_012967.1 similar to b0899; putative transporter 965752 ycaM 8175711 ycaM Escherichia coli B str. REL606 putative transporter YP_003044121.1 964322 D 413997 CDS YP_003044122.1 254161014 8175712 complement(965753..966661) 1 NC_012967.1 similar to b0900; putative DNA-binding transcriptional regulator 966661 ycaN 8175712 ycaN Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003044122.1 965753 R 413997 CDS YP_003044123.1 254161015 8175713 966761..967351 1 NC_012967.1 similar to b0901; hypothetical protein 967351 ycaK 8175713 ycaK Escherichia coli B str. REL606 hypothetical protein YP_003044123.1 966761 D 413997 CDS YP_003044124.1 254161016 8175714 complement(967433..968173) 1 NC_012967.1 activates pyruvate formate-lyase 1 under anaerobic conditions; pyruvate formate lyase-activating enzyme 1 968173 pflA 8175714 pflA Escherichia coli B str. REL606 pyruvate formate lyase-activating enzyme 1 YP_003044124.1 967433 R 413997 CDS YP_003044125.1 254161017 8178414 complement(968365..970647) 1 NC_012967.1 similar to b0903; pyruvate formate lyase I 970647 pflB 8178414 pflB Escherichia coli B str. REL606 pyruvate formate lyase I YP_003044125.1 968365 R 413997 CDS YP_003044126.1 254161018 8178415 complement(970702..971559) 1 NC_012967.1 similar to b0904; formate transporter 971559 focA 8178415 focA Escherichia coli B str. REL606 formate transporter YP_003044126.1 970702 R 413997 CDS YP_003044127.1 254161019 8175715 complement(971964..973724) 1 NC_012967.1 similar to b0905; hypothetical protein 973724 ycaO 8175715 ycaO Escherichia coli B str. REL606 hypothetical protein YP_003044127.1 971964 R 413997 CDS YP_003044128.1 254161020 8178969 973854..974546 1 NC_012967.1 similar to b0906; inner membrane protein 974546 ycaP 8178969 ycaP Escherichia coli B str. REL606 inner membrane protein YP_003044128.1 973854 D 413997 CDS YP_003044129.1 254161021 8175716 974745..975833 1 NC_012967.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase 975833 serC 8175716 serC Escherichia coli B str. REL606 phosphoserine aminotransferase YP_003044129.1 974745 D 413997 CDS YP_003044130.1 254161022 8175717 975904..977187 1 NC_012967.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 977187 aroA 8175717 aroA Escherichia coli B str. REL606 3-phosphoshikimate 1-carboxyvinyltransferase YP_003044130.1 975904 D 413997 CDS YP_003044131.1 254161023 8175718 977356..978120 1 NC_012967.1 similar to b0909; putative peptidase with chaperone function 978120 ycaL 8175718 ycaL Escherichia coli B str. REL606 putative peptidase with chaperone function YP_003044131.1 977356 D 413997 CDS YP_003044132.1 254161024 8175719 978293..978976 1 NC_012967.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 978976 cmk 8175719 cmk Escherichia coli B str. REL606 cytidylate kinase YP_003044132.1 978293 D 413997 CDS YP_003044133.1 254161025 8178970 979087..980760 1 NC_012967.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 980760 rpsA 8178970 rpsA Escherichia coli B str. REL606 30S ribosomal protein S1 YP_003044133.1 979087 D 413997 CDS YP_003044134.1 254161026 8175720 980920..981204 1 NC_012967.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit beta 981204 ihfB 8175720 ihfB Escherichia coli B str. REL606 integration host factor subunit beta YP_003044134.1 980920 D 413997 CDS YP_003044135.1 254161027 8175721 981412..983676 1 NC_012967.1 similar to b0913; hypothetical protein 983676 ycaI 8175721 ycaI Escherichia coli B str. REL606 hypothetical protein YP_003044135.1 981412 D 413997 CDS YP_003044136.1 254161028 8175722 983713..985461 1 NC_012967.1 involved in the transport of lipid A across the inner membrane; lipid transporter ATP-binding/permease 985461 msbA 8175722 msbA Escherichia coli B str. REL606 lipid transporter ATP-binding/permease YP_003044136.1 983713 D 413997 CDS YP_003044137.1 254161029 8178971 985458..986444 1 NC_012967.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate; tetraacyldisaccharide 4'-kinase 986444 lpxK 8178971 lpxK Escherichia coli B str. REL606 tetraacyldisaccharide 4'-kinase YP_003044137.1 985458 D 413997 CDS YP_003044138.1 254161030 8175723 986481..987713 1 NC_012967.1 similar to b0916; hypothetical protein 987713 ycaQ 8175723 ycaQ Escherichia coli B str. REL606 hypothetical protein YP_003044138.1 986481 D 413997 CDS YP_003044139.1 254161031 8175724 987765..987947 1 NC_012967.1 similar to b0917; hypothetical protein 987947 ycaR 8175724 ycaR Escherichia coli B str. REL606 hypothetical protein YP_003044139.1 987765 D 413997 CDS YP_003044140.1 254161032 8175725 987944..988690 1 NC_012967.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 988690 kdsB 8175725 kdsB Escherichia coli B str. REL606 3-deoxy-manno-octulosonate cytidylyltransferase YP_003044140.1 987944 D 413997 CDS YP_003044141.1 254161033 8175726 988844..989737 1 NC_012967.1 similar to b0919; hypothetical protein 989737 ycbJ 8175726 ycbJ Escherichia coli B str. REL606 hypothetical protein YP_003044141.1 988844 D 413997 CDS YP_003044142.1 254161034 8178416 complement(989714..990493) 1 NC_012967.1 similar to b0920; hypothetical protein 990493 ycbC 8178416 ycbC Escherichia coli B str. REL606 hypothetical protein YP_003044142.1 989714 R 413997 CDS YP_003044143.1 254161035 8175727 990629..991414 1 NC_012967.1 involved in cellular zinc and cadmium homeostasis by binding excess metal ions to its cysteine sulfurs and histidine nitrogens; expression of smtA in cyanobacteria is repressed by SmtB at low concentrations of zinc; NO elicits release of Zn ions from SmtA; putative metallothionein SmtA 991414 smtA 8175727 smtA Escherichia coli B str. REL606 putative metallothionein SmtA YP_003044143.1 990629 D 413997 CDS YP_003044144.1 254161036 8175728 991411..992733 1 NC_012967.1 acts with MukB and MukE to condense the chromosome and allow for segregation during cell division; condesin subunit F 992733 mukF 8175728 mukF Escherichia coli B str. REL606 condesin subunit F YP_003044144.1 991411 D 413997 CDS YP_003044145.1 254161037 8178417 992741..993418 1 NC_012967.1 acts with MukB and MukF to condense the chromosome and allow for segregation during cell division; condesin subunit E 993418 mukE 8178417 mukE Escherichia coli B str. REL606 condesin subunit E YP_003044145.1 992741 D 413997 CDS YP_003044146.1 254161038 8175729 993418..997878 1 NC_012967.1 SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects; cell division protein MukB 997878 mukB 8175729 mukB Escherichia coli B str. REL606 cell division protein MukB YP_003044146.1 993418 D 413997 CDS YP_003044147.1 254161039 8178972 998139..999986 1 NC_012967.1 similar to b0925; hypothetical protein 999986 ycbB 8178972 ycbB Escherichia coli B str. REL606 hypothetical protein YP_003044147.1 998139 D 413997 CDS YP_003044148.1 254161040 8175730 1000167..1000715 1 NC_012967.1 similar to b0926; hypothetical protein 1000715 ycbK 8175730 ycbK Escherichia coli B str. REL606 hypothetical protein YP_003044148.1 1000167 D 413997 CDS YP_003044149.1 254161041 8175731 1000742..1001389 1 NC_012967.1 similar to b0927; putative metal-binding enzyme 1001389 ycbL 8175731 ycbL Escherichia coli B str. REL606 putative metal-binding enzyme YP_003044149.1 1000742 D 413997 CDS YP_003044150.1 254161042 8175732 complement(1001611..1002801) 1 NC_012967.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 1002801 aspC 8175732 aspC Escherichia coli B str. REL606 aromatic amino acid aminotransferase YP_003044150.1 1001611 R 413997 CDS YP_003044151.1 254161043 8175733 complement(1002986..1004074) 1 NC_012967.1 outer membrane porin F; 1a; Ia; b; outer membrane protein F 1004074 ompF 8175733 ompF Escherichia coli B str. REL606 outer membrane protein F YP_003044151.1 1002986 R 413997 CDS YP_003044152.1 254161044 8178418 complement(1004676..1006076) 1 NC_012967.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase 1006076 asnC 8178418 asnC Escherichia coli B str. REL606 asparaginyl-tRNA synthetase YP_003044152.1 1004676 R 413997 CDS YP_003044153.1 254161045 8175734 complement(1006245..1007447) 1 NC_012967.1 catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 1007447 pncB 8175734 pncB Escherichia coli B str. REL606 nicotinate phosphoribosyltransferase YP_003044153.1 1006245 R 413997 CDS YP_003044154.1 254161046 8178419 1007713..1010325 1 NC_012967.1 similar to b0932; aminopeptidase N 1010325 pepN 8178419 pepN Escherichia coli B str. REL606 aminopeptidase N YP_003044154.1 1007713 D 413997 CDS YP_003044155.1 254161047 8175735 complement(1010368..1011135) 1 NC_012967.1 part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic substrate-binding subunit, SsuB the ATP-binding subunit and SsuC the permease; aliphatic sulfonates transport ATP-binding subunit 1011135 ssuB 8175735 ssuB Escherichia coli B str. REL606 aliphatic sulfonates transport ATP-binding subunit YP_003044155.1 1010368 R 413997 CDS YP_003044156.1 254161048 8175736 complement(1011132..1011923) 1 NC_012967.1 part of the ABC type transport system for alkanesulfonate SsuABC; SsuB the ATP-binding subunit and SsuC the permease; alkanesulfonate transporter permease 1011923 ssuC 8175736 ssuC Escherichia coli B str. REL606 alkanesulfonate transporter permease YP_003044156.1 1011132 R 413997 CDS YP_003044157.1 254161049 8178420 complement(1011934..1013079) 1 NC_012967.1 catalyzes the release of sulfite from alkanesulfonates; alkanesulfonate monooxygenase 1013079 ssuD 8178420 ssuD Escherichia coli B str. REL606 alkanesulfonate monooxygenase YP_003044157.1 1011934 R 413997 CDS YP_003044158.1 254161050 8175737 complement(1013076..1014035) 1 NC_012967.1 part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic subunit SsuB the ATP-binding subunit and SsuC the permease; alkanesulfonate transporter substrate-binding subunit 1014035 ssuA 8175737 ssuA Escherichia coli B str. REL606 alkanesulfonate transporter substrate-binding subunit YP_003044158.1 1013076 R 413997 CDS YP_003044159.1 254161051 8175738 complement(1014028..1014603) 1 NC_012967.1 similar to b0937; NAD(P)H-dependent FMN reductase 1014603 ssuE 8175738 ssuE Escherichia coli B str. REL606 NAD(P)H-dependent FMN reductase YP_003044159.1 1014028 R 413997 CDS YP_003044160.1 254161052 8175739 1014959..1015498 1 NC_012967.1 similar to b0938; putative fimbrial-like adhesin protein 1015498 ycbQ 8175739 ycbQ Escherichia coli B str. REL606 putative fimbrial-like adhesin protein YP_003044160.1 1014959 D 413997 CDS YP_003044161.1 254161053 8175740 1015581..1016282 1 NC_012967.1 similar to b0939; putative periplasmic pilin chaperone 1016282 ycbR 8175740 ycbR Escherichia coli B str. REL606 putative periplasmic pilin chaperone YP_003044161.1 1015581 D 413997 CDS YP_003044162.1 254161054 8175741 1016307..1018907 1 NC_012967.1 similar to b0940; putative outer membrane usher protein 1018907 ycbS 8175741 ycbS Escherichia coli B str. REL606 putative outer membrane usher protein YP_003044162.1 1016307 D 413997 CDS YP_003044163.1 254161055 8178421 1018898..1019968 1 NC_012967.1 similar to b0941; putative fimbrial-like adhesin protein 1019968 ycbT 8178421 ycbT Escherichia coli B str. REL606 putative fimbrial-like adhesin protein YP_003044163.1 1018898 D 413997 CDS YP_003044164.1 254161056 8175742 1019980..1020522 1 NC_012967.1 similar to b0942; putative fimbrial-like adhesin protein 1020522 ycbU 8175742 ycbU Escherichia coli B str. REL606 putative fimbrial-like adhesin protein YP_003044164.1 1019980 D 413997 CDS YP_003044165.1 254161057 8175743 1020530..1021045 1 NC_012967.1 similar to b0943; putative fimbrial-like adhesin protein 1021045 ycbV 8175743 ycbV Escherichia coli B str. REL606 putative fimbrial-like adhesin protein YP_003044165.1 1020530 D 413997 CDS YP_003044166.1 254161058 8175744 1021038..1021748 1 NC_012967.1 similar to b0944; putativi pili assembly chaperone 1021748 ycbF 8175744 ycbF Escherichia coli B str. REL606 putativi pili assembly chaperone YP_003044166.1 1021038 D 413997 CDS YP_003044167.1 254161059 8175745 1021859..1022869 1 NC_012967.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 1022869 pyrD 8175745 pyrD Escherichia coli B str. REL606 dihydroorotate dehydrogenase 2 YP_003044167.1 1021859 D 413997 CDS YP_003044168.1 254161060 8178422 1023043..1023585 1 NC_012967.1 similar to b0946; hypothetical protein 1023585 ycbW 8178422 ycbW Escherichia coli B str. REL606 hypothetical protein YP_003044168.1 1023043 D 413997 CDS YP_003044169.1 254161061 8175746 complement(1023582..1024691) 1 NC_012967.1 similar to b0947; putative 2Fe-2S cluster-containing protein 1024691 ycbX 8175746 ycbX Escherichia coli B str. REL606 putative 2Fe-2S cluster-containing protein YP_003044169.1 1023582 R 413997 CDS YP_003044170.1 254161062 8175747 1024935..1027043 1 NC_012967.1 catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA; 23S rRNA m(2)G2445 methyltransferase 1027043 rlmL 8175747 rlmL Escherichia coli B str. REL606 23S rRNA m(2)G2445 methyltransferase YP_003044170.1 1024935 D 413997 CDS YP_003044171.1 254161063 8175748 1027055..1028962 1 NC_012967.1 Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth; ABC transporter ATPase component 1028962 uup 8175748 uup Escherichia coli B str. REL606 ABC transporter ATPase component YP_003044171.1 1027055 D 413997 CDS YP_003044172.1 254161064 8175749 1029092..1030345 1 NC_012967.1 similar to b0950; paraquat-inducible membrane protein A 1030345 pqiA 8175749 pqiA Escherichia coli B str. REL606 paraquat-inducible membrane protein A YP_003044172.1 1029092 D 413997 CDS YP_003044173.1 254161065 8178423 1030350..1031990 1 NC_012967.1 similar to b0951; paraquat-inducible protein B 1031990 pqiB 8178423 pqiB Escherichia coli B str. REL606 paraquat-inducible protein B YP_003044173.1 1030350 D 413997 CDS YP_003044174.1 254161066 8175750 1032002..1032550 1 NC_012967.1 similar to b0952; hypothetical protein 1032550 ymbA 8175750 ymbA Escherichia coli B str. REL606 hypothetical protein YP_003044174.1 1032002 D 413997 CDS YP_003044175.1 254161067 8175751 1032806..1032973 1 NC_012967.1 similar to b0953; ribosome modulation factor 1032973 rmf 8175751 rmf Escherichia coli B str. REL606 ribosome modulation factor YP_003044175.1 1032806 D 413997 CDS YP_003044176.1 254161068 8175752 complement(1033043..1033561) 1 NC_012967.1 catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP; 3-hydroxydecanoyl-(acyl carrier protein) dehydratase 1033561 fabA 8175752 fabA Escherichia coli B str. REL606 3-hydroxydecanoyl-(acyl carrier protein) dehydratase YP_003044176.1 1033043 R 413997 CDS YP_003044177.1 254161069 8175753 complement(1033630..1035390) 1 NC_012967.1 similar to b0955; putative peptidase 1035390 ycbZ 8175753 ycbZ Escherichia coli B str. REL606 putative peptidase YP_003044177.1 1033630 R 413997 CDS YP_003044178.1 254161070 8175754 1035576..1036028 1 NC_012967.1 similar to b0956; hypothetical protein 1036028 ycbG 8175754 ycbG Escherichia coli B str. REL606 hypothetical protein YP_003044178.1 1035576 D 413997 CDS YP_003044179.1 254161071 8175755 complement(1036104..1037144) 1 NC_012967.1 OmpA is believed to be a porin, involved in diffusion of nonspecific small solutes across the outer membrane. It is the most abundant integral protein of the outer membrane of E. coli, and it is known to play a role as a phage receptor, a mediator of F-factor dependent conjugation, and in maintaining the structural shape of the outer membrane; 3a; II*; G; d; outer membrane protein A 1037144 ompA 8175755 ompA Escherichia coli B str. REL606 outer membrane protein A YP_003044179.1 1036104 R 413997 CDS YP_003044180.1 254161072 8178424 complement(1037501..1038010) 1 NC_012967.1 similar to b0958; SOS cell division inhibitor 1038010 sulA 8178424 sulA Escherichia coli B str. REL606 SOS cell division inhibitor YP_003044180.1 1037501 R 413997 CDS YP_003044181.1 254161073 8175756 1038229..1038858 1 NC_012967.1 similar to b0959; hypothetical protein 1038858 yccR 8175756 yccR Escherichia coli B str. REL606 hypothetical protein YP_003044181.1 1038229 D 413997 CDS YP_003044182.1 254161074 8175757 complement(1038821..1040974) 1 NC_012967.1 similar to b0960; putative inner membrane protein 1040974 yccS 8175757 yccS Escherichia coli B str. REL606 putative inner membrane protein YP_003044182.1 1038821 R 413997 CDS YP_003044183.1 254161075 8175758 complement(1040993..1041439) 1 NC_012967.1 similar to b0961; hypothetical protein 1041439 yccF 8175758 yccF Escherichia coli B str. REL606 hypothetical protein YP_003044183.1 1040993 R 413997 CDS YP_003044184.1 254161076 8175759 1041562..1043616 1 NC_012967.1 catalyzes the ATP-dependent unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand; DNA helicase IV 1043616 helD 8175759 helD Escherichia coli B str. REL606 DNA helicase IV YP_003044184.1 1041562 D 413997 CDS YP_003044185.1 254161077 8178425 complement(1043648..1044106) 1 NC_012967.1 catalyzes the formation of methylglyoxal from glycerone phosphate; methylglyoxal synthase 1044106 mgsA 8178425 mgsA Escherichia coli B str. REL606 methylglyoxal synthase YP_003044185.1 1043648 R 413997 CDS YP_003044186.1 254161078 8175760 complement(1044202..1044864) 1 NC_012967.1 similar to b0964; hypothetical protein 1044864 yccT 8175760 yccT Escherichia coli B str. REL606 hypothetical protein YP_003044186.1 1044202 R 413997 CDS YP_003044187.1 254161079 8175761 1045037..1045450 1 NC_012967.1 similar to b0965; putative CoA-binding protein with NAD(P)-binding Rossmann-fold domain 1045450 yccU 8175761 yccU Escherichia coli B str. REL606 putative CoA-binding protein with NAD(P)-binding Rossmann-fold domain YP_003044187.1 1045037 D 413997 CDS YP_003044188.1 254161080 8175762 complement(1045495..1045812) 1 NC_012967.1 similar to b0966; heat shock protein HspQ 1045812 yccV 8175762 yccV Escherichia coli B str. REL606 heat shock protein HspQ YP_003044188.1 1045495 R 413997 CDS YP_003044189.1 254161081 8175763 complement(1045870..1046973) 1 NC_012967.1 similar to b0967; putative methyltransferase 1046973 yccW 8175763 yccW Escherichia coli B str. REL606 putative methyltransferase YP_003044189.1 1045870 R 413997 CDS YP_003044190.1 254161082 8178973 1047155..1047433 1 NC_012967.1 catalyzes the hydrolysis of acylphosphate; acylphosphatase 1047433 yccX 8178973 yccX Escherichia coli B str. REL606 acylphosphatase YP_003044190.1 1047155 D 413997 CDS YP_003044191.1 254161083 8175764 complement(1047430..1047759) 1 NC_012967.1 transfers sulfur from TusBCD complex to MnmA; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein TusE 1047759 yccK 8175764 yccK Escherichia coli B str. REL606 sulfur transfer protein TusE YP_003044191.1 1047430 R 413997 CDS YP_003044192.1 254161084 8175765 complement(1047850..1048509) 1 NC_012967.1 similar to b0970; hypothetical protein 1048509 yccA 8175765 yccA Escherichia coli B str. REL606 hypothetical protein YP_003044192.1 1047850 R 413997 CDS YP_003044193.1 254161085 8175766 1049230..1050348 1 NC_012967.1 similar to b0972; hydrogenase 1, small subunit 1050348 hyaA 8175766 hyaA Escherichia coli B str. REL606 hydrogenase 1, small subunit YP_003044193.1 1049230 D 413997 CDS YP_003044194.1 254161086 8175767 1050345..1052138 1 NC_012967.1 involved in hydrogen cycling during fermentative growth; hydrogenase 1 large subunit 1052138 hyaB 8175767 hyaB Escherichia coli B str. REL606 hydrogenase 1 large subunit YP_003044194.1 1050345 D 413997 CDS YP_003044195.1 254161087 8175768 1052157..1052864 1 NC_012967.1 similar to b0974; hydrogenase 1 b-type cytochrome subunit 1052864 hyaC 8175768 hyaC Escherichia coli B str. REL606 hydrogenase 1 b-type cytochrome subunit YP_003044195.1 1052157 D 413997 CDS YP_003044196.1 254161088 8175769 1052861..1053448 1 NC_012967.1 HyaD; endopeptidase involved in the cleavage of the C-terminus end of HyaB (the large subunit of hydrogenase 1); hydrogenase 1 maturation protease 1053448 hyaD 8175769 hyaD Escherichia coli B str. REL606 hydrogenase 1 maturation protease YP_003044196.1 1052861 D 413997 CDS YP_003044197.1 254161089 8178975 1053445..1053843 1 NC_012967.1 involved in processing hydrogenase proteins HyaA and HyaB; hydrogenase-1 operon protein HyaE 1053843 hyaE 8178975 hyaE Escherichia coli B str. REL606 hydrogenase-1 operon protein HyaE YP_003044197.1 1053445 D 413997 CDS YP_003044198.1 254161090 8175770 1053840..1054697 1 NC_012967.1 similar to b0977; protein involved in nickel incorporation into hydrogenase-1 proteins; HyaF 1054697 hyaF 8175770 hyaF Escherichia coli B str. REL606 HyaF YP_003044198.1 1053840 D 413997 CDS YP_003044199.1 254161091 8175771 1054831..1056375 1 NC_012967.1 similar to b0978; cytochrome bd-II oxidase, subunit I 1056375 appC 8175771 appC Escherichia coli B str. REL606 cytochrome bd-II oxidase, subunit I YP_003044199.1 1054831 D 413997 CDS YP_003044200.1 254161092 8178976 1056387..1057523 1 NC_012967.1 similar to b0979; cytochrome bd-II oxidase, subunit II 1057523 appB 8178976 appB Escherichia coli B str. REL606 cytochrome bd-II oxidase, subunit II YP_003044200.1 1056387 D 413997 CDS YP_003044201.1 254161093 8175772 1057708..1059006 1 NC_012967.1 similar to b0980; phosphoanhydride phosphorylase 1059006 appA 8175772 appA Escherichia coli B str. REL606 phosphoanhydride phosphorylase YP_003044201.1 1057708 D 413997 CDS YP_003044202.1 254161094 8178977 complement(1059121..1061301) 1 NC_012967.1 similar to b0981; cryptic autophosphorylating protein tyrosine kinase Etk 1061301 yccC 8178977 yccC Escherichia coli B str. REL606 cryptic autophosphorylating protein tyrosine kinase Etk YP_003044202.1 1059121 R 413997 CDS YP_003044203.1 254161095 8175773 complement(1061321..1061767) 1 NC_012967.1 Etk and Etp are a tyrosine kinase-tyrosine phosphatase pair, etp dephosphorylates etk; phosphotyrosine-protein phosphatase 1061767 etp 8175773 etp Escherichia coli B str. REL606 phosphotyrosine-protein phosphatase YP_003044203.1 1061321 R 413997 CDS YP_003044204.1 254161096 8175774 complement(1061755..1062894) 1 NC_012967.1 similar to b0983; putative exopolysaccharide export protein 1062894 yccZ 8175774 yccZ Escherichia coli B str. REL606 putative exopolysaccharide export protein YP_003044204.1 1061755 R 413997 CDS YP_003044205.1 254161097 8175775 complement(1062940..1065036) 1 NC_012967.1 similar to b0984; hypothetical protein 1065036 ymcA 8175775 ymcA Escherichia coli B str. REL606 hypothetical protein YP_003044205.1 1062940 R 413997 CDS YP_003044206.1 254161098 8175776 complement(1065036..1065782) 1 NC_012967.1 similar to b0985; hypothetical protein 1065782 ymcB 8175776 ymcB Escherichia coli B str. REL606 hypothetical protein YP_003044206.1 1065036 R 413997 CDS YP_003044207.1 254161099 8178426 complement(1065779..1066423) 1 NC_012967.1 similar to b0986; putative outer membrane lipoprotein 1066423 ymcC 8178426 ymcC Escherichia coli B str. REL606 putative outer membrane lipoprotein YP_003044207.1 1065779 R 413997 CDS YP_003044208.1 254161100 8175777 complement(1066530..1066835) 1 NC_012967.1 similar to b0987; hypothetical protein 1066835 ymcD 8175777 ymcD Escherichia coli B str. REL606 hypothetical protein YP_003044208.1 1066530 R 413997 CDS YP_003044209.1 254161101 8178978 complement(1067254..1067466) 1 NC_012967.1 similar to b0989; stress protein, member of the CspA-family 1067466 cspH 8178978 cspH Escherichia coli B str. REL606 stress protein, member of the CspA-family YP_003044209.1 1067254 R 413997 CDS YP_003044210.1 254161102 8175778 1067752..1067964 1 NC_012967.1 similar to b0990; cold shock protein CspG 1067964 cspG 8175778 cspG Escherichia coli B str. REL606 cold shock protein CspG YP_003044210.1 1067752 D 413997 CDS YP_003044211.1 254161103 8175779 1068138..1068368 1 NC_012967.1 similar to b0991; cold shock gene 1068368 sfa 8175779 sfa Escherichia coli B str. REL606 cold shock gene YP_003044211.1 1068138 D 413997 CDS YP_003044212.1 254161104 8178979 1068358..1068531 1 NC_012967.1 similar to b4517; putative regulator of phosphatidylethanolamine synthesis 1068531 gnsA 8178979 gnsA Escherichia coli B str. REL606 putative regulator of phosphatidylethanolamine synthesis YP_003044212.1 1068358 D 413997 CDS YP_003044213.1 254161105 8175780 complement(1068579..1069652) 1 NC_012967.1 similar to b0992; putative 4Fe-4S membrane protein 1069652 yccM 8175780 yccM Escherichia coli B str. REL606 putative 4Fe-4S membrane protein YP_003044213.1 1068579 R 413997 CDS YP_003044214.1 254161106 8178980 complement(1069724..1072468) 1 NC_012967.1 Member of the two-component regulatory system torS/torR involved in the anaerobic utilization of trimethylamine-N-oxide; hybrid sensory histidine kinase TorS 1072468 torS 8178980 torS Escherichia coli B str. REL606 hybrid sensory histidine kinase TorS YP_003044214.1 1069724 R 413997 CDS YP_003044215.1 254161107 8175781 1072551..1073579 1 NC_012967.1 periplasmic sensory protein associated with the TorRS two-component regulatory system; TMAO reductase system periplasmic protein TorT 1073579 torT 8175781 torT Escherichia coli B str. REL606 TMAO reductase system periplasmic protein TorT YP_003044215.1 1072551 D 413997 CDS YP_003044216.1 254161108 8175782 complement(1073552..1074244) 1 NC_012967.1 response regulator in two-component regulatory system with TorS; involved in regulation of trimethylamine N-oxide reductase genes; DNA-binding transcriptional regulator TorR 1074244 torR 8175782 torR Escherichia coli B str. REL606 DNA-binding transcriptional regulator TorR YP_003044216.1 1073552 R 413997 CDS YP_003044217.1 254161109 8175783 1074374..1075546 1 NC_012967.1 similar to b0996; trimethylamine N-oxide (TMAO) reductase I, cytochrome c-type subunit 1075546 torC 8175783 torC Escherichia coli B str. REL606 trimethylamine N-oxide (TMAO) reductase I, cytochrome c-type subunit YP_003044217.1 1074374 D 413997 CDS YP_003044218.1 254161110 8175784 1075546..1078092 1 NC_012967.1 similar to b0997; trimethylamine N-oxide (TMAO) reductase I, catalytic subunit 1078092 torA 8175784 torA Escherichia coli B str. REL606 trimethylamine N-oxide (TMAO) reductase I, catalytic subunit YP_003044218.1 1075546 D 413997 CDS YP_003044219.1 254161111 8178427 1078089..1078688 1 NC_012967.1 TorD; involved in the biogenesis of torA; acts on torA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor; chaperone protein TorD 1078688 torD 8178427 torD Escherichia coli B str. REL606 chaperone protein TorD YP_003044219.1 1078089 D 413997 CDS YP_003044220.1 254161112 8175785 complement(1078840..1079145) 1 NC_012967.1 with CpbA modulates the activity of the dnaK chaperone system; interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA; chaperone-modulator protein CbpM 1079145 yccD 8175785 yccD Escherichia coli B str. REL606 chaperone-modulator protein CbpM YP_003044220.1 1078840 R 413997 CDS YP_003044221.1 254161113 8175786 complement(1079145..1080065) 1 NC_012967.1 functional analog of DnaJ; co-chaperone with DnaK, molecular chaperone in an adaptive response to environmental stresses other than heat shock; curved DNA-binding protein CbpA 1080065 cbpA 8175786 cbpA Escherichia coli B str. REL606 curved DNA-binding protein CbpA YP_003044221.1 1079145 R 413997 CDS YP_003044222.1 254161114 8175787 1080326..1081585 1 NC_012967.1 similar to b1001; hypothetical protein 1081585 yccE 8175787 yccE Escherichia coli B str. REL606 hypothetical protein YP_003044222.1 1080326 D 413997 CDS YP_003044223.1 254161115 8175788 1081868..1083109 1 NC_012967.1 similar to b1002; glucose-1-phosphatase/inositol phosphatase 1083109 agp 8175788 agp Escherichia coli B str. REL606 glucose-1-phosphatase/inositol phosphatase YP_003044223.1 1081868 D 413997 CDS YP_003044224.1 254161116 8178981 complement(1083147..1083374) 1 NC_012967.1 similar to b1003; hypothetical protein 1083374 yccJ 8178981 yccJ Escherichia coli B str. REL606 hypothetical protein YP_003044224.1 1083147 R 413997 CDS YP_003044225.1 254161117 8178982 complement(1083395..1083991) 1 NC_012967.1 stationary phase protein that binds TrpR repressor; TrpR binding protein WrbA 1083991 wrbA 8178982 wrbA Escherichia coli B str. REL606 TrpR binding protein WrbA YP_003044225.1 1083395 R 413997 CDS YP_003044226.1 254161118 8175789 1084364..1084537 1 NC_012967.1 similar to b4518; hypothetical protein 1084537 ymdF 8175789 ymdF Escherichia coli B str. REL606 hypothetical protein YP_003044226.1 1084364 D 413997 CDS YP_003044227.1 254161119 8175790 complement(1084795..1086123) 1 NC_012967.1 similar to b1006; putative transporter 1086123 ycdG 8175790 ycdG Escherichia coli B str. REL606 putative transporter YP_003044227.1 1084795 R 413997 CDS YP_003044228.1 254161120 8175791 complement(1086144..1086638) 1 NC_012967.1 similar to b1007; putative oxidoreductase, flavin:NADH component 1086638 ycdH 8175791 ycdH Escherichia coli B str. REL606 putative oxidoreductase, flavin:NADH component YP_003044228.1 1086144 R 413997 CDS YP_003044229.1 254161121 8175792 complement(1086649..1087239) 1 NC_012967.1 similar to b1008; hypothetical protein 1087239 ycdI 8175792 ycdI Escherichia coli B str. REL606 hypothetical protein YP_003044229.1 1086649 R 413997 CDS YP_003044230.1 254161122 8175793 complement(1087249..1088049) 1 NC_012967.1 similar to b1009; putative hydrolase 1088049 ycdJ 8175793 ycdJ Escherichia coli B str. REL606 putative hydrolase YP_003044230.1 1087249 R 413997 CDS YP_003044231.1 254161123 8175794 complement(1088057..1088443) 1 NC_012967.1 similar to b1010; hypothetical protein 1088443 ycdK 8175794 ycdK Escherichia coli B str. REL606 hypothetical protein YP_003044231.1 1088057 R 413997 CDS YP_003044232.1 254161124 8175795 complement(1088455..1089147) 1 NC_012967.1 similar to b1011; hypothetical protein 1089147 ycdL 8175795 ycdL Escherichia coli B str. REL606 hypothetical protein YP_003044232.1 1088455 R 413997 CDS YP_003044233.1 254161125 8178428 complement(1089147..1090295) 1 NC_012967.1 similar to b1012; putative monooxygenase 1090295 ycdM 8178428 ycdM Escherichia coli B str. REL606 putative monooxygenase YP_003044233.1 1089147 R 413997 CDS YP_003044234.1 254161126 8175796 1090526..1091164 1 NC_012967.1 similar to b1013; putative DNA-binding transcriptional regulator 1091164 ycdC 8175796 ycdC Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003044234.1 1090526 D 413997 CDS YP_003044235.1 254161127 8175797 complement(1091204..1095166) 1 NC_012967.1 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichai coli this protein also self-regulates transcription via a DNA-binding domain at the N-terminus; forms dimers and is a peripherally membrane-associated protein; trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 1095166 putA 8175797 putA Escherichia coli B str. REL606 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase YP_003044235.1 1091204 R 413997 CDS YP_003044236.1 254161128 8178983 1095589..1097097 1 NC_012967.1 similar to b1015; proline:sodium symporter 1097097 putP 8178983 putP Escherichia coli B str. REL606 proline:sodium symporter YP_003044236.1 1095589 D 413997 CDS YP_003044237.1 254161129 8178984 1097631..1098470 1 NC_012967.1 similar to b1016-b1017(b4490); hypothetical protein 1098470 ycdN 8178984 ycdN Escherichia coli B str. REL606 hypothetical protein YP_003044237.1 1097631 D 413997 CDS YP_003044238.1 254161130 8175798 1098528..1099655 1 NC_012967.1 similar to b1018; hypothetical protein 1099655 ycdO 8175798 ycdO Escherichia coli B str. REL606 hypothetical protein YP_003044238.1 1098528 D 413997 CDS YP_003044239.1 254161131 8175799 1099661..1100932 1 NC_012967.1 similar to b1019; hypothetical protein 1100932 ycdB 8175799 ycdB Escherichia coli B str. REL606 hypothetical protein YP_003044239.1 1099661 D 413997 CDS YP_003044240.1 254161132 8175800 1101277..1102341 1 NC_012967.1 similar to b1020; hypothetical protein 1102341 phoH 8175800 phoH Escherichia coli B str. REL606 hypothetical protein YP_003044240.1 1101277 D 413997 CDS YP_003044241.1 254161133 8175801 complement(1102391..1102804) 1 NC_012967.1 in Yersinia this gene is involved in biofilm formation and hemin adsorption; in Escherichia coli it is involved in PGA biosynthesis and export; putative PGA biosynthesis protein 1102804 pgaD 8175801 pgaD Escherichia coli B str. REL606 putative PGA biosynthesis protein YP_003044241.1 1102391 R 413997 CDS YP_003044242.1 254161134 8175802 complement(1102806..1104131) 1 NC_012967.1 predicted polysaccharide polymerase involved in biofilm formation; required for the synthesis of the beta-1,6-N-acetylglucosamine polysaccharide; PgaC; in Yersinia the HmsR protein is an inner membrane protein; N-glycosyltransferase 1104131 ycdQ 8175802 ycdQ Escherichia coli B str. REL606 N-glycosyltransferase YP_003044242.1 1102806 R 413997 CDS YP_003044243.1 254161135 8175803 complement(1104124..1106142) 1 NC_012967.1 in Yersinia this protein is involved in biofilm formation and hemin adsorption; related protein PgaB in Escherichia coli is an outer membrane N-deacetylase involved in poly-beta-1,6-N-acetyl-D-glucosamine (PGA) export; outer membrane N-deacetylase 1106142 pgaB 8175803 pgaB Escherichia coli B str. REL606 outer membrane N-deacetylase YP_003044243.1 1104124 R 413997 CDS YP_003044244.1 254161136 8175804 complement(1106151..1108574) 1 NC_012967.1 outer membrane protein essential for the synthesis of poly-beta-1,6-N-acetyl-D-glucosamine (PGA); adhesin required for biofilm formation; PgaA (HmsH) seems to translocate and/or dock PGA to the cell surface; member of the hmsHFRS (ycdSRQP or pgaABCD in Escherichia coli) operon in Yersinia; outer membrane protein PgaA 1108574 pgaA 8175804 pgaA Escherichia coli B str. REL606 outer membrane protein PgaA YP_003044244.1 1106151 R 413997 CDS YP_003044245.1 254161137 8178429 1109161..1110519 1 NC_012967.1 similar to b1025; putative diguanylate cyclase 1110519 ycdT 8178429 ycdT Escherichia coli B str. REL606 putative diguanylate cyclase YP_003044245.1 1109161 D 413997 CDS YP_003044246.1 254161138 8175805 complement(1110560..1111375) 1 NC_012967.1 putative transposase for IS3 1111375 insF-1 8175805 insF-1 Escherichia coli B str. REL606 putative transposase for IS3 YP_003044246.1 1110560 R 413997 CDS YP_003044247.1 254161139 8175806 complement(1111423..1111731) 1 NC_012967.1 putative transposase-related protein 1111731 insE-1 8175806 insE-1 Escherichia coli B str. REL606 putative transposase-related protein YP_003044247.1 1111423 R 413997 CDS YP_003044248.1 254161140 8175808 1112455..1113393 1 NC_012967.1 similar to b1033; 2-ketoacid reductase 1113393 ycdW 8175808 ycdW Escherichia coli B str. REL606 2-ketoacid reductase YP_003044248.1 1112455 D 413997 CDS YP_003044249.1 254161141 8178430 1113448..1114185 1 NC_012967.1 similar to b1034; putative hydrolase 1114185 ycdX 8178430 ycdX Escherichia coli B str. REL606 putative hydrolase YP_003044249.1 1113448 D 413997 CDS YP_003044250.1 254161142 8175809 1114209..1114763 1 NC_012967.1 similar to b1035; hypothetical protein 1114763 ycdY 8175809 ycdY Escherichia coli B str. REL606 hypothetical protein YP_003044250.1 1114209 D 413997 CDS YP_003044251.1 254161143 8175810 1114865..1115356 1 NC_012967.1 similar to b1036; putative inner membrane protein 1115356 ycdZ 8175810 ycdZ Escherichia coli B str. REL606 putative inner membrane protein YP_003044251.1 1114865 D 413997 CDS YP_003044252.1 254161144 8175811 complement(1115420..1116253) 1 NC_012967.1 similar to b1037; outer membrane lipoprotein 1116253 csgG 8175811 csgG Escherichia coli B str. REL606 outer membrane lipoprotein YP_003044252.1 1115420 R 413997 CDS YP_003044253.1 254161145 8175812 complement(1116280..1116696) 1 NC_012967.1 nucleator protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgF 1116696 csgF 8175812 csgF Escherichia coli B str. REL606 curli assembly protein CsgF YP_003044253.1 1116280 R 413997 CDS YP_003044254.1 254161146 8175813 complement(1116721..1117110) 1 NC_012967.1 chaperone-like protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgE 1117110 csgE 8175813 csgE Escherichia coli B str. REL606 curli assembly protein CsgE YP_003044254.1 1116721 R 413997 CDS YP_003044255.1 254161147 8175814 complement(1117115..1117765) 1 NC_012967.1 activates the csgBA and csgDEFG operons involved in biofilm formation; DNA-binding transcriptional regulator CsgD 1117765 csgD 8175814 csgD Escherichia coli B str. REL606 DNA-binding transcriptional regulator CsgD YP_003044255.1 1117115 R 413997 CDS YP_003044256.1 254161148 8178431 1118520..1118975 1 NC_012967.1 CsgB; functions as a nucleator in the assembly of curli (coiled surface structures) on the cell surface; curlin minor subunit 1118975 csgB 8178431 csgB Escherichia coli B str. REL606 curlin minor subunit YP_003044256.1 1118520 D 413997 CDS YP_003044257.1 254161149 8175815 1119016..1119471 1 NC_012967.1 similar to b1042; cryptic curlin major subunit 1119471 csgA 8175815 csgA Escherichia coli B str. REL606 cryptic curlin major subunit YP_003044257.1 1119016 D 413997 CDS YP_003044258.1 254161150 8175816 1119530..1119862 1 NC_012967.1 involved in autoagglutination of curliated cells; not involved in production of curli fibers; putative autoagglutination protein 1119862 csgC 8175816 csgC Escherichia coli B str. REL606 putative autoagglutination protein YP_003044258.1 1119530 D 413997 CDS YP_003044259.1 254161151 8175817 1119983..1120294 1 NC_012967.1 similar to b1044; hypothetical protein 1120294 ymdA 8175817 ymdA Escherichia coli B str. REL606 hypothetical protein YP_003044259.1 1119983 D 413997 CDS YP_003044260.1 254161152 8175818 1120389..1120922 1 NC_012967.1 similar to b1045; hypothetical protein 1120922 ymdB 8175818 ymdB Escherichia coli B str. REL606 hypothetical protein YP_003044260.1 1120389 D 413997 CDS YP_003044261.1 254161153 8178432 1120924..1122345 1 NC_012967.1 similar to b1046; putative hydrolase 1122345 ymdC 8178432 ymdC Escherichia coli B str. REL606 putative hydrolase YP_003044261.1 1120924 D 413997 CDS YP_003044262.1 254161154 8178985 complement(1122353..1123510) 1 NC_012967.1 required for the transfer of succinyl residues to the glucan backbone; glucans biosynthesis protein 1123510 mdoC 8178985 mdoC Escherichia coli B str. REL606 glucans biosynthesis protein YP_003044262.1 1122353 R 413997 CDS YP_003044263.1 254161155 8175819 1123904..1125439 1 NC_012967.1 involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan; glucan biosynthesis protein G 1125439 mdoG 8175819 mdoG Escherichia coli B str. REL606 glucan biosynthesis protein G YP_003044263.1 1123904 D 413997 CDS YP_003044264.1 254161156 8175820 1125432..1127975 1 NC_012967.1 necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space; glucosyltransferase MdoH 1127975 mdoH 8175820 mdoH Escherichia coli B str. REL606 glucosyltransferase MdoH YP_003044264.1 1125432 D 413997 CDS YP_003044265.1 254161157 8175821 1128148..1128375 1 NC_012967.1 similar to b1050; hypothetical protein 1128375 yceK 8175821 yceK Escherichia coli B str. REL606 hypothetical protein YP_003044265.1 1128148 D 413997 CDS YP_003044266.1 254161158 8175822 complement(1128376..1128750) 1 NC_012967.1 similar to b1051; hypothetical protein 1128750 msyB 8175822 msyB Escherichia coli B str. REL606 hypothetical protein YP_003044266.1 1128376 R 413997 CDS YP_003044267.1 254161159 8178433 complement(1128833..1130059) 1 NC_012967.1 Confers resistance to fosfomycin and deoxycholate; drug efflux system protein MdtG 1130059 yceE 8178433 yceE Escherichia coli B str. REL606 drug efflux system protein MdtG YP_003044267.1 1128833 R 413997 CDS YP_003044268.1 254161160 8178434 complement(1130231..1131151) 1 NC_012967.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase 1131151 htrB 8178434 htrB Escherichia coli B str. REL606 lipid A biosynthesis lauroyl acyltransferase YP_003044268.1 1130231 R 413997 CDS YP_003044269.1 254161161 8175823 1131376..1132428 1 NC_012967.1 similar to b1055; hypothetical protein 1132428 yceA 8175823 yceA Escherichia coli B str. REL606 hypothetical protein YP_003044269.1 1131376 D 413997 CDS YP_003044270.1 254161162 8175824 complement(1132470..1133045) 1 NC_012967.1 similar to b1056; hypothetical protein 1133045 yceI 8175824 yceI Escherichia coli B str. REL606 hypothetical protein YP_003044270.1 1132470 R 413997 CDS YP_003044271.1 254161163 8175825 complement(1133049..1133615) 1 NC_012967.1 similar to b1057; putative cytochrome b561 1133615 yceJ 8175825 yceJ Escherichia coli B str. REL606 putative cytochrome b561 YP_003044271.1 1133049 R 413997 CDS YP_003044272.1 254161164 8175826 complement(1133876..1134016) 1 NC_012967.1 similar to b1058; hypothetical protein 1134016 yceO 8175826 yceO Escherichia coli B str. REL606 hypothetical protein YP_003044272.1 1133876 R 413997 CDS YP_003044273.1 254161165 8178435 complement(1134037..1135155) 1 NC_012967.1 catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids; N-methyltryptophan oxidase 1135155 solA 8178435 solA Escherichia coli B str. REL606 N-methyltryptophan oxidase YP_003044273.1 1134037 R 413997 CDS YP_003044274.1 254161166 8178986 complement(1135270..1135524) 1 NC_012967.1 BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing; biofilm formation regulatory protein BssS 1135524 bssS 8178986 bssS Escherichia coli B str. REL606 biofilm formation regulatory protein BssS YP_003044274.1 1135270 R 413997 CDS YP_003044275.1 254161167 8175827 complement(1135814..1136059) 1 NC_012967.1 similar to b1061; DNA damage-inducible protein I 1136059 dinI 8175827 dinI Escherichia coli B str. REL606 DNA damage-inducible protein I YP_003044275.1 1135814 R 413997 CDS YP_003044276.1 254161168 8175828 complement(1136133..1137179) 1 NC_012967.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 1137179 pyrC 8175828 pyrC Escherichia coli B str. REL606 dihydroorotase YP_003044276.1 1136133 R 413997 CDS YP_003044277.1 254161169 8175829 complement(1137285..1137845) 1 NC_012967.1 similar to b1063; hypothetical protein 1137845 yceB 8175829 yceB Escherichia coli B str. REL606 hypothetical protein YP_003044277.1 1137285 R 413997 CDS YP_003044278.1 254161170 8175830 complement(1137979..1138626) 1 NC_012967.1 cofactor involved in the reduction of disulfides; glutaredoxin 2 1138626 grxB 8175830 grxB Escherichia coli B str. REL606 glutaredoxin 2 YP_003044278.1 1137979 R 413997 CDS YP_003044279.1 254161171 8178987 complement(1138690..1139898) 1 NC_012967.1 Confers resistance to norfloxacin and enoxacin; multidrug resistance protein MdtH 1139898 yceL 8178987 yceL Escherichia coli B str. REL606 multidrug resistance protein MdtH YP_003044279.1 1138690 R 413997 CDS YP_003044280.1 254161172 8178988 1140134..1140718 1 NC_012967.1 similar to b1066; ribosomal-protein-S5-alanine N-acetyltransferase 1140718 rimJ 8178988 rimJ Escherichia coli B str. REL606 ribosomal-protein-S5-alanine N-acetyltransferase YP_003044280.1 1140134 D 413997 CDS YP_003044281.1 254161173 8175831 1140729..1141376 1 NC_012967.1 similar to b1067; hypothetical protein 1141376 yceH 8175831 yceH Escherichia coli B str. REL606 hypothetical protein YP_003044281.1 1140729 D 413997 CDS YP_003044282.1 254161174 8175832 1141378..1142301 1 NC_012967.1 similar to b1068; putative oxidoreductase with NAD(P)-binding Rossmann-fold domain 1142301 mviM 8175832 mviM Escherichia coli B str. REL606 putative oxidoreductase with NAD(P)-binding Rossmann-fold domain YP_003044282.1 1141378 D 413997 CDS YP_003044283.1 254161175 8175833 1142411..1143946 1 NC_012967.1 similar to b1069; putative inner membrane protein 1143946 mviN 8175833 mviN Escherichia coli B str. REL606 putative inner membrane protein YP_003044283.1 1142411 D 413997 CDS YP_003044284.1 254161176 8175834 complement(1143986..1144402) 1 NC_012967.1 similar to b1070; export chaperone for FlgK and FlgL 1144402 flgN 8175834 flgN Escherichia coli B str. REL606 export chaperone for FlgK and FlgL YP_003044284.1 1143986 R 413997 CDS YP_003044285.1 254161177 8178436 complement(1144407..1144700) 1 NC_012967.1 regulates the flagellar specific sigma28 transcription factor; anti-sigma28 factor FlgM 1144700 flgM 8178436 flgM Escherichia coli B str. REL606 anti-sigma28 factor FlgM YP_003044285.1 1144407 R 413997 CDS YP_003044286.1 254161178 8178989 complement(1144776..1145435) 1 NC_012967.1 required for the assembly of the flagellar basal body P-ring; flagellar basal body P-ring biosynthesis protein FlgA 1145435 flgA 8178989 flgA Escherichia coli B str. REL606 flagellar basal body P-ring biosynthesis protein FlgA YP_003044286.1 1144776 R 413997 CDS YP_003044287.1 254161179 8175835 1145590..1146006 1 NC_012967.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella; flagellar basal body rod protein FlgB 1146006 flgB 8175835 flgB Escherichia coli B str. REL606 flagellar basal body rod protein FlgB YP_003044287.1 1145590 D 413997 CDS YP_003044288.1 254161180 8175836 1146010..1146414 1 NC_012967.1 with FlgF and B makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgC 1146414 flgC 8175836 flgC Escherichia coli B str. REL606 flagellar basal body rod protein FlgC YP_003044288.1 1146010 D 413997 CDS YP_003044289.1 254161181 8175837 1146426..1147121 1 NC_012967.1 acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production; flagellar basal body rod modification protein 1147121 flgD 8175837 flgD Escherichia coli B str. REL606 flagellar basal body rod modification protein YP_003044289.1 1146426 D 413997 CDS YP_003044290.1 254161182 8175838 1147146..1148351 1 NC_012967.1 the hook connects flagellar basal body to the flagellar filament; flagellar hook protein FlgE 1148351 flgE 8175838 flgE Escherichia coli B str. REL606 flagellar hook protein FlgE YP_003044290.1 1147146 D 413997 CDS YP_003044291.1 254161183 8178990 1148371..1149126 1 NC_012967.1 FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgF 1149126 flgF 8178990 flgF Escherichia coli B str. REL606 flagellar basal body rod protein FlgF YP_003044291.1 1148371 D 413997 CDS YP_003044292.1 254161184 8175839 1149298..1150080 1 NC_012967.1 makes up the distal portion of the flagellar basal body rod; flagellar basal body rod protein FlgG 1150080 flgG 8175839 flgG Escherichia coli B str. REL606 flagellar basal body rod protein FlgG YP_003044292.1 1149298 D 413997 CDS YP_003044293.1 254161185 8175840 1150133..1150831 1 NC_012967.1 part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod; flagellar basal body L-ring protein 1150831 flgH 8175840 flgH Escherichia coli B str. REL606 flagellar basal body L-ring protein YP_003044293.1 1150133 D 413997 CDS YP_003044294.1 254161186 8175841 1150843..1151940 1 NC_012967.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum; flagellar basal body P-ring protein 1151940 flgI 8175841 flgI Escherichia coli B str. REL606 flagellar basal body P-ring protein YP_003044294.1 1150843 D 413997 CDS YP_003044295.1 254161187 8175842 1151940..1152881 1 NC_012967.1 Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space; flagellar rod assembly protein/muramidase FlgJ 1152881 flgJ 8175842 flgJ Escherichia coli B str. REL606 flagellar rod assembly protein/muramidase FlgJ YP_003044295.1 1151940 D 413997 CDS YP_003044296.1 254161188 8178437 1152947..1154590 1 NC_012967.1 with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook; flagellar hook-associated protein FlgK 1154590 flgK 8178437 flgK Escherichia coli B str. REL606 flagellar hook-associated protein FlgK YP_003044296.1 1152947 D 413997 CDS YP_003044297.1 254161189 8175843 1154602..1155555 1 NC_012967.1 with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of this and other flagellar genes; flagellar hook-associated protein FlgL 1155555 flgL 8175843 flgL Escherichia coli B str. REL606 flagellar hook-associated protein FlgL YP_003044297.1 1154602 D 413997 CDS YP_003044298.1 254161190 8175844 complement(1155751..1158936) 1 NC_012967.1 bifunctional ribonuclease E/endoribonuclease/RNA-binding protein/RNA degradosome binding protein; forms part of the membrane-associated degradosome complex along with PNPase, RhlB, and enolase; ribonuclease E 1158936 rne 8175844 rne Escherichia coli B str. REL606 ribonuclease E YP_003044298.1 1155751 R 413997 CDS YP_003044299.1 254161191 8178438 1159071..1159391 1 NC_012967.1 similar to b1085; hypothetical protein 1159391 8178438 ECB_01081 Escherichia coli B str. REL606 hypothetical protein YP_003044299.1 1159071 D 413997 CDS YP_003044300.1 254161192 8175845 1159509..1160468 1 NC_012967.1 catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA; 23S rRNA pseudouridylate synthase C 1160468 rluC 8175845 rluC Escherichia coli B str. REL606 23S rRNA pseudouridylate synthase C YP_003044300.1 1159509 D 413997 CDS YP_003044301.1 254161193 8175846 complement(1160580..1161164) 1 NC_012967.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 1161164 yceF 8175846 yceF Escherichia coli B str. REL606 Maf-like protein YP_003044301.1 1160580 R 413997 CDS YP_003044302.1 254161194 8175847 1161363..1161884 1 NC_012967.1 similar to b1088; hypothetical protein 1161884 yceD 8175847 yceD Escherichia coli B str. REL606 hypothetical protein YP_003044302.1 1161363 D 413997 CDS YP_003044303.1 254161195 8175848 1161936..1162109 1 NC_012967.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 1162109 rpmF 8175848 rpmF Escherichia coli B str. REL606 50S ribosomal protein L32 YP_003044303.1 1161936 D 413997 CDS YP_003044304.1 254161196 8175849 1162190..1163260 1 NC_012967.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; putative glycerol-3-phosphate acyltransferase PlsX 1163260 plsX 8175849 plsX Escherichia coli B str. REL606 putative glycerol-3-phosphate acyltransferase PlsX YP_003044304.1 1162190 D 413997 CDS YP_003044305.1 254161197 8175850 1163328..1164281 1 NC_012967.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-(acyl carrier protein) synthase III 1164281 fabH 8175850 fabH Escherichia coli B str. REL606 3-oxoacyl-(acyl carrier protein) synthase III YP_003044305.1 1163328 D 413997 CDS YP_003044306.1 254161198 8178991 1164297..1165226 1 NC_012967.1 similar to b1092; acyl carrier protein S-malonyltransferase 1165226 fabD 8178991 fabD Escherichia coli B str. REL606 acyl carrier protein S-malonyltransferase YP_003044306.1 1164297 D 413997 CDS YP_003044307.1 254161199 8175851 1165239..1165973 1 NC_012967.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-(acyl-carrier-protein) reductase 1165973 fabG 8175851 fabG Escherichia coli B str. REL606 3-ketoacyl-(acyl-carrier-protein) reductase YP_003044307.1 1165239 D 413997 CDS YP_003044308.1 254161200 8175852 1166184..1166420 1 NC_012967.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 1166420 acpP 8175852 acpP Escherichia coli B str. REL606 acyl carrier protein YP_003044308.1 1166184 D 413997 CDS YP_003044309.1 254161201 8178992 1166508..1167749 1 NC_012967.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase II 1167749 fabF 8178992 fabF Escherichia coli B str. REL606 3-oxoacyl-(acyl carrier protein) synthase II YP_003044309.1 1166508 D 413997 CDS YP_003044310.1 254161202 8175853 1167869..1168678 1 NC_012967.1 catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate; 4-amino-4-deoxychorismate lyase 1168678 pabC 8175853 pabC Escherichia coli B str. REL606 4-amino-4-deoxychorismate lyase YP_003044310.1 1167869 D 413997 CDS YP_003044311.1 254161203 8178439 1168681..1169703 1 NC_012967.1 similar to b1097; hypothetical protein 1169703 yceG 8178439 yceG Escherichia coli B str. REL606 hypothetical protein YP_003044311.1 1168681 D 413997 CDS YP_003044312.1 254161204 8175854 1169693..1170334 1 NC_012967.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 1170334 tmk 8175854 tmk Escherichia coli B str. REL606 thymidylate kinase YP_003044312.1 1169693 D 413997 CDS YP_003044313.1 254161205 8175855 1170331..1171335 1 NC_012967.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 1171335 holB 8175855 holB Escherichia coli B str. REL606 DNA polymerase III subunit delta' YP_003044313.1 1170331 D 413997 CDS YP_003044314.1 254161206 8178440 1171346..1172143 1 NC_012967.1 similar to b1100; putative metallodependent hydrolase 1172143 ycfH 8178440 ycfH Escherichia coli B str. REL606 putative metallodependent hydrolase YP_003044314.1 1171346 D 413997 CDS YP_003044315.1 254161207 8175856 1172438..1173871 1 NC_012967.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system glucose-specific transporter subunits IIBC 1173871 ptsG 8175856 ptsG Escherichia coli B str. REL606 PTS system glucose-specific transporter subunits IIBC YP_003044315.1 1172438 D 413997 CDS YP_003044316.1 254161208 8175857 complement(1173931..1176120) 1 NC_012967.1 similar to b1102; ferric-rhodotorulic acid outer membrane transporter 1176120 fhuE 8175857 fhuE Escherichia coli B str. REL606 ferric-rhodotorulic acid outer membrane transporter YP_003044316.1 1173931 R 413997 CDS YP_003044317.1 254161209 8175858 1176454..1176813 1 NC_012967.1 similar to b1103; purine nucleoside phosphoramidase 1176813 ycfF 8175858 ycfF Escherichia coli B str. REL606 purine nucleoside phosphoramidase YP_003044317.1 1176454 D 413997 CDS YP_003044318.1 254161210 8175859 1176816..1177193 1 NC_012967.1 similar to b1104; hypothetical protein 1177193 ycfL 8175859 ycfL Escherichia coli B str. REL606 hypothetical protein YP_003044318.1 1176816 D 413997 CDS YP_003044319.1 254161211 8175860 1177207..1177848 1 NC_012967.1 similar to b1105; putative outer membrane lipoprotein 1177848 ycfM 8175860 ycfM Escherichia coli B str. REL606 putative outer membrane lipoprotein YP_003044319.1 1177207 D 413997 CDS YP_003044320.1 254161212 8178993 1177829..1178653 1 NC_012967.1 catalyzes the phosphorylation of thiamine to thiamine phosphate; thiamine kinase 1178653 thiK 8178993 thiK Escherichia coli B str. REL606 thiamine kinase YP_003044320.1 1177829 D 413997 CDS YP_003044321.1 254161213 8175861 1178664..1179689 1 NC_012967.1 hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides; beta-hexosaminidase 1179689 nagZ 8175861 nagZ Escherichia coli B str. REL606 beta-hexosaminidase YP_003044321.1 1178664 D 413997 CDS YP_003044322.1 254161214 8175862 1179712..1180254 1 NC_012967.1 similar to b1108; hypothetical protein 1180254 ycfP 8175862 ycfP Escherichia coli B str. REL606 hypothetical protein YP_003044322.1 1179712 D 413997 CDS YP_003044323.1 254161215 8178441 1180662..1181966 1 NC_012967.1 similar to b1109; respiratory NADH dehydrogenase 2/cupric reductase 1181966 ndh 8178441 ndh Escherichia coli B str. REL606 respiratory NADH dehydrogenase 2/cupric reductase YP_003044323.1 1180662 D 413997 CDS YP_003044324.1 254161216 8175863 1182193..1182732 1 NC_012967.1 similar to b1110; hypothetical protein 1182732 ycfJ 8175863 ycfJ Escherichia coli B str. REL606 hypothetical protein YP_003044324.1 1182193 D 413997 CDS YP_003044325.1 254161217 8175864 complement(1182794..1183426) 1 NC_012967.1 similar to b1111; putative DNA-binding transcriptional regulator 1183426 ycfQ 8175864 ycfQ Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003044325.1 1182794 R 413997 CDS YP_003044326.1 254161218 8175865 1183667..1183924 1 NC_012967.1 similar to b1112; hypothetical protein 1183924 ycfR 8175865 ycfR Escherichia coli B str. REL606 hypothetical protein YP_003044326.1 1183667 D 413997 CDS YP_003044327.1 254161219 8175866 complement(1184007..1184969) 1 NC_012967.1 similar to b1113; hypothetical protein 1184969 ycfS 8175866 ycfS Escherichia coli B str. REL606 hypothetical protein YP_003044327.1 1184007 R 413997 CDS YP_003044328.1 254161220 8175867 complement(1185113..1188559) 1 NC_012967.1 similar to b1114; transcription-repair coupling factor 1188559 mfd 8175867 mfd Escherichia coli B str. REL606 transcription-repair coupling factor YP_003044328.1 1185113 R 413997 CDS YP_003044329.1 254161221 8175868 complement(1188687..1189760) 1 NC_012967.1 similar to b1115; putative inner membrane protein 1189760 ycfT 8175868 ycfT Escherichia coli B str. REL606 putative inner membrane protein YP_003044329.1 1188687 R 413997 CDS YP_003044330.1 254161222 8178994 1190022..1191221 1 NC_012967.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolC 1191221 ycfU 8178994 ycfU Escherichia coli B str. REL606 outer membrane-specific lipoprotein transporter subunit LolC YP_003044330.1 1190022 D 413997 CDS YP_003044331.1 254161223 8175869 1191214..1191915 1 NC_012967.1 outer membrane specific; part of transporter complex lolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone; lipoprotein transporter ATP-binding subunit 1191915 lolD 8175869 lolD Escherichia coli B str. REL606 lipoprotein transporter ATP-binding subunit YP_003044331.1 1191214 D 413997 CDS YP_003044332.1 254161224 8175870 1191915..1193159 1 NC_012967.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolE 1193159 ycfW 8175870 ycfW Escherichia coli B str. REL606 outer membrane-specific lipoprotein transporter subunit LolE YP_003044332.1 1191915 D 413997 CDS YP_003044333.1 254161225 8175871 1193670..1193945 1 NC_012967.1 IS1 protein InsA 1193945 insA-10 8175871 insA-10 Escherichia coli B str. REL606 IS1 protein InsA YP_003044333.1 1193670 D 413997 CDS YP_003044334.1 254161226 8178442 1193864..1194367 1 NC_012967.1 IS1 protein InsB 1194367 insB-10 8178442 insB-10 Escherichia coli B str. REL606 IS1 protein InsB YP_003044334.1 1193864 D 413997 CDS YP_003044335.1 254161227 8175872 1194892..1195731 1 NC_012967.1 Modulates the activities of several enzymes which are inactive in their acetylated form; NAD-dependent deacetylase 1195731 cobB 8175872 cobB Escherichia coli B str. REL606 NAD-dependent deacetylase YP_003044335.1 1194892 D 413997 CDS YP_003044336.1 254161228 8175873 complement(1195850..1196638) 1 NC_012967.1 similar to b1121; putative inner membrane protein 1196638 ycfZ 8175873 ycfZ Escherichia coli B str. REL606 putative inner membrane protein YP_003044336.1 1195850 R 413997 CDS YP_003044337.1 254161229 8178443 complement(1196688..1197095) 1 NC_012967.1 similar to b1122; putative inner membrane protein 1197095 ymfA 8178443 ymfA Escherichia coli B str. REL606 putative inner membrane protein YP_003044337.1 1196688 R 413997 CDS YP_003044338.1 254161230 8175874 complement(1197153..1198199) 1 NC_012967.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotD is a periplasmic component that binds the substrate; spermidine/putrescine ABC transporter periplasmic substrate-binding protein 1198199 potD 8175874 potD Escherichia coli B str. REL606 spermidine/putrescine ABC transporter periplasmic substrate-binding protein YP_003044338.1 1197153 R 413997 CDS YP_003044339.1 254161231 8175875 complement(1198196..1198990) 1 NC_012967.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component; spermidine/putrescine ABC transporter membrane protein 1198990 potC 8175875 potC Escherichia coli B str. REL606 spermidine/putrescine ABC transporter membrane protein YP_003044339.1 1198196 R 413997 CDS YP_003044340.1 254161232 8175876 complement(1198987..1199814) 1 NC_012967.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component; spermidine/putrescine ABC transporter membrane protein 1199814 potB 8175876 potB Escherichia coli B str. REL606 spermidine/putrescine ABC transporter membrane protein YP_003044340.1 1198987 R 413997 CDS YP_003044341.1 254161233 8178996 complement(1199828..1200964) 1 NC_012967.1 functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase; putrescine/spermidine ABC transporter ATPase protein 1200964 potA 8178996 potA Escherichia coli B str. REL606 putrescine/spermidine ABC transporter ATPase protein YP_003044341.1 1199828 R 413997 CDS YP_003044342.1 254161234 8175877 1201214..1202440 1 NC_012967.1 catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T 1202440 pepT 8175877 pepT Escherichia coli B str. REL606 peptidase T YP_003044342.1 1201214 D 413997 CDS YP_003044343.1 254161235 8175878 complement(1202489..1203610) 1 NC_012967.1 similar to b1128; hypothetical protein 1203610 ycfD 8175878 ycfD Escherichia coli B str. REL606 hypothetical protein YP_003044343.1 1202489 R 413997 CDS YP_003044344.1 254161236 8178997 complement(1203686..1205146) 1 NC_012967.1 similar to b1129; sensor protein PhoQ 1205146 phoQ 8178997 phoQ Escherichia coli B str. REL606 sensor protein PhoQ YP_003044344.1 1203686 R 413997 CDS YP_003044345.1 254161237 8175879 complement(1205146..1205817) 1 NC_012967.1 response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress; DNA-binding transcriptional regulator PhoP 1205817 phoP 8175879 phoP Escherichia coli B str. REL606 DNA-binding transcriptional regulator PhoP YP_003044345.1 1205146 R 413997 CDS YP_003044346.1 254161238 8175880 complement(1205985..1207355) 1 NC_012967.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 1207355 purB 8175880 purB Escherichia coli B str. REL606 adenylosuccinate lyase YP_003044346.1 1205985 R 413997 CDS YP_003044347.1 254161239 8178998 complement(1207359..1208000) 1 NC_012967.1 HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis; hypothetical protein 1208000 ycfC 8178998 ycfC Escherichia coli B str. REL606 hypothetical protein YP_003044347.1 1207359 R 413997 CDS YP_003044348.1 254161240 8175881 complement(1208036..1209142) 1 NC_012967.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 1209142 mnmA 8175881 mnmA Escherichia coli B str. REL606 tRNA-specific 2-thiouridylase MnmA YP_003044348.1 1208036 R 413997 CDS YP_003044349.1 254161241 8175882 complement(1209196..1209657) 1 NC_012967.1 similar to b1134; bifunctional thiamin pyrimidine pyrophosphate hydrolase/ thiamin pyrophosphate hydrolase 1209657 ymfB 8175882 ymfB Escherichia coli B str. REL606 bifunctional thiamin pyrimidine pyrophosphate hydrolase/ thiamin pyrophosphate hydrolase YP_003044349.1 1209196 R 413997 CDS YP_003044350.1 254161242 8175883 complement(1209667..1210320) 1 NC_012967.1 catalyzes the formation of pseudouridine from uracil-2457 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase E 1210320 ymfC 8175883 ymfC Escherichia coli B str. REL606 23S rRNA pseudouridine synthase E YP_003044350.1 1209667 R 413997 CDS YP_003044351.1 254161243 8178999 1210492..1211742 1 NC_012967.1 Converts isocitrate to alpha ketoglutarate; isocitrate dehydrogenase 1211742 icdA 8178999 icdA Escherichia coli B str. REL606 isocitrate dehydrogenase YP_003044351.1 1210492 D 413997 CDS YP_003044352.1 254161244 8175884 complement(1211845..1212168) 1 NC_012967.1 similar to b1160; hypothetical protein 1212168 ycgW 8175884 ycgW Escherichia coli B str. REL606 hypothetical protein YP_003044352.1 1211845 R 413997 CDS YP_003044353.1 254161245 8175885 complement(1212864..1213268) 1 NC_012967.1 similar to b1161; hypothetical protein 1213268 ycgX 8175885 ycgX Escherichia coli B str. REL606 hypothetical protein YP_003044353.1 1212864 R 413997 CDS YP_003044354.1 254161246 8179000 complement(1213489..1214220) 1 NC_012967.1 similar to b1162; putative DNA-binding transcriptional regulator 1214220 ycgE 8179000 ycgE Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003044354.1 1213489 R 413997 CDS YP_003044355.1 254161247 8175886 complement(1214425..1215636) 1 NC_012967.1 similar to b1163; putative FAD-binding phosphodiesterase 1215636 ycgF 8175886 ycgF Escherichia coli B str. REL606 putative FAD-binding phosphodiesterase YP_003044355.1 1214425 R 413997 CDS YP_003044356.1 254161248 8175887 1215950..1216186 1 NC_012967.1 similar to b1164; hypothetical protein 1216186 ycgZ 8175887 ycgZ Escherichia coli B str. REL606 hypothetical protein YP_003044356.1 1215950 D 413997 CDS YP_003044357.1 254161249 8175888 1216229..1216501 1 NC_012967.1 similar to b1165; hypothetical protein 1216501 ymgA 8175888 ymgA Escherichia coli B str. REL606 hypothetical protein YP_003044357.1 1216229 D 413997 CDS YP_003044358.1 254161250 8175889 1216530..1216796 1 NC_012967.1 similar to b1166; hypothetical protein 1216796 ymgB 8175889 ymgB Escherichia coli B str. REL606 hypothetical protein YP_003044358.1 1216530 D 413997 CDS YP_003044359.1 254161251 8178444 1216909..1217157 1 NC_012967.1 similar to b1167; hypothetical protein 1217157 ymgC 8178444 ymgC Escherichia coli B str. REL606 hypothetical protein YP_003044359.1 1216909 D 413997 CDS YP_003044360.1 254161252 8175890 1217489..1219012 1 NC_012967.1 similar to b1168; inner membrane protein 1219012 ycgG 8175890 ycgG Escherichia coli B str. REL606 inner membrane protein YP_003044360.1 1217489 D 413997 CDS YP_003044361.1 254161253 8175891 1219144..1219362 1 NC_012967.1 similar to b4520; hypothetical protein 1219362 ymgF 8175891 ymgF Escherichia coli B str. REL606 hypothetical protein YP_003044361.1 1219144 D 413997 CDS YP_003044362.1 254161254 8175893 complement(1222466..1222795) 1 NC_012967.1 similar to b1171; hypothetical protein 1222795 ymgD 8175893 ymgD Escherichia coli B str. REL606 hypothetical protein YP_003044362.1 1222466 R 413997 CDS YP_003044363.1 254161255 8175894 complement(1222805..1223080) 1 NC_012967.1 similar to b1172; hypothetical protein 1223080 8175894 ECB_01147 Escherichia coli B str. REL606 hypothetical protein YP_003044363.1 1222805 R 413997 CDS YP_003044364.1 254161256 8175895 1223856..1224068 1 NC_012967.1 similar to b1173; hypothetical protein 1224068 ycgI 8175895 ycgI Escherichia coli B str. REL606 hypothetical protein YP_003044364.1 1223856 D 413997 CDS YP_003044365.1 254161257 8179001 complement(1224440..1224706) 1 NC_012967.1 works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell; cell division topological specificity factor MinE 1224706 minE 8179001 minE Escherichia coli B str. REL606 cell division topological specificity factor MinE YP_003044365.1 1224440 R 413997 CDS YP_003044366.1 254161258 8175896 complement(1224710..1225522) 1 NC_012967.1 ATPase; with MinC inhibits cell division by blocking formation of the polar Z ring septums; cell division inhibitor MinD 1225522 minD 8175896 minD Escherichia coli B str. REL606 cell division inhibitor MinD YP_003044366.1 1224710 R 413997 CDS YP_003044367.1 254161259 8175897 complement(1225546..1226241) 1 NC_012967.1 blocks the formation of polar Z-ring septums; septum formation inhibitor 1226241 minC 8175897 minC Escherichia coli B str. REL606 septum formation inhibitor YP_003044367.1 1225546 R 413997 CDS YP_003044368.1 254161260 8179002 1226761..1227129 1 NC_012967.1 similar to b1177; hypothetical protein 1227129 ycgJ 8179002 ycgJ Escherichia coli B str. REL606 hypothetical protein YP_003044368.1 1226761 D 413997 CDS YP_003044369.1 254161261 8175898 complement(1227232..1227633) 1 NC_012967.1 similar to b1178; hypothetical protein 1227633 ycgK 8175898 ycgK Escherichia coli B str. REL606 hypothetical protein YP_003044369.1 1227232 R 413997 CDS YP_003044370.1 254161262 8175899 1227842..1228168 1 NC_012967.1 similar to b1179; hypothetical protein 1228168 ycgL 8175899 ycgL Escherichia coli B str. REL606 hypothetical protein YP_003044370.1 1227842 D 413997 CDS YP_003044371.1 254161263 8178445 1228240..1228899 1 NC_012967.1 similar to b1180; hypothetical protein 1228899 ycgM 8178445 ycgM Escherichia coli B str. REL606 hypothetical protein YP_003044371.1 1228240 D 413997 CDS YP_003044372.1 254161264 8175900 1228991..1229437 1 NC_012967.1 similar to b1181; hypothetical protein 1229437 ycgN 8175900 ycgN Escherichia coli B str. REL606 hypothetical protein YP_003044372.1 1228991 D 413997 CDS YP_003044373.1 254161265 8175902 1230917..1231336 1 NC_012967.1 binds with UmuC protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuD 1231336 umuD 8175902 umuD Escherichia coli B str. REL606 DNA polymerase V subunit UmuD YP_003044373.1 1230917 D 413997 CDS YP_003044374.1 254161266 8175903 1231336..1232604 1 NC_012967.1 binds processed UmuD protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuC 1232604 umuC 8175903 umuC Escherichia coli B str. REL606 DNA polymerase V subunit UmuC YP_003044374.1 1231336 D 413997 CDS YP_003044375.1 254161267 8175904 complement(1232650..1233180) 1 NC_012967.1 disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein; disulfide bond formation protein B 1233180 dsbB 8175904 dsbB Escherichia coli B str. REL606 disulfide bond formation protein B YP_003044375.1 1232650 R 413997 CDS YP_003044376.1 254161268 8175905 complement(1233326..1234867) 1 NC_012967.1 involved in regulation of intracellular pH under alkaline conditions; sodium/proton antiporter 1234867 nhaB 8175905 nhaB Escherichia coli B str. REL606 sodium/proton antiporter YP_003044376.1 1233326 R 413997 CDS YP_003044377.1 254161269 8178446 1235088..1235807 1 NC_012967.1 Multifunctional regulator of fatty acid metabolism; fatty acid metabolism regulator 1235807 fadR 8178446 fadR Escherichia coli B str. REL606 fatty acid metabolism regulator YP_003044377.1 1235088 D 413997 CDS YP_003044378.1 254161270 8175906 complement(1235859..1237391) 1 NC_012967.1 similar to b1188; SpoVR family protein 1237391 ycgB 8175906 ycgB Escherichia coli B str. REL606 SpoVR family protein YP_003044378.1 1235859 R 413997 CDS YP_003044379.1 254161271 8178447 1237721..1239019 1 NC_012967.1 catalyzes the oxidative deamination of D-amino acids; D-amino acid dehydrogenase small subunit 1239019 dadA 8178447 dadA Escherichia coli B str. REL606 D-amino acid dehydrogenase small subunit YP_003044379.1 1237721 D 413997 CDS YP_003044380.1 254161272 8175907 1239029..1240099 1 NC_012967.1 catabolic enzyme, converts L-alanine to D-alanine which is then oxidized to pyruvate by dadA; alanine racemase 1240099 dadX 8175907 dadX Escherichia coli B str. REL606 alanine racemase YP_003044380.1 1239029 D 413997 CDS YP_003044381.1 254161273 8175908 complement(1240485..1242221) 1 NC_012967.1 the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli; potassium/proton antiporter 1242221 ycgO 8175908 ycgO Escherichia coli B str. REL606 potassium/proton antiporter YP_003044381.1 1240485 R 413997 CDS YP_003044382.1 254161274 8175909 complement(1242316..1243230) 1 NC_012967.1 catalyzes the release of D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine; L,D-carboxypeptidase A 1243230 ldcA 8175909 ldcA Escherichia coli B str. REL606 L,D-carboxypeptidase A YP_003044382.1 1242316 R 413997 CDS YP_003044383.1 254161275 8175910 1243330..1243941 1 NC_012967.1 similar to b1193; lytic murein endotransglycosylase E 1243941 mltE 8175910 mltE Escherichia coli B str. REL606 lytic murein endotransglycosylase E YP_003044383.1 1243330 D 413997 CDS YP_003044384.1 254161276 8179003 complement(1243943..1244677) 1 NC_012967.1 similar to b1194; protein involved in flagellar function; YcgR 1244677 ycgR 8179003 ycgR Escherichia coli B str. REL606 YcgR YP_003044384.1 1243943 R 413997 CDS YP_003044385.1 254161277 8175911 1244878..1245132 1 NC_012967.1 similar to b1195; putative inner membrane protein 1245132 ymgE 8175911 ymgE Escherichia coli B str. REL606 putative inner membrane protein YP_003044385.1 1244878 D 413997 CDS YP_003044386.1 254161278 8175912 1245310..1245750 1 NC_012967.1 similar to b1196; hypothetical protein 1245750 ycgY 8175912 ycgY Escherichia coli B str. REL606 hypothetical protein YP_003044386.1 1245310 D 413997 CDS YP_003044387.1 254161279 8175913 complement(1245829..1247526) 1 NC_012967.1 periplasmic; catalyzes the hydrolysis of trehalose to glucose which can then be imported into the cell; trehalase 1247526 treA 8175913 treA Escherichia coli B str. REL606 trehalase YP_003044387.1 1245829 R 413997 CDS YP_003044388.1 254161280 8178448 complement(1247846..1249264) 1 NC_012967.1 phosphotransferaese subunit; phosphorylates dihydroxyacetone along with DhaK/DhaL; dihydroxyacetone kinase subunit M 1249264 dhaM 8178448 dhaM Escherichia coli B str. REL606 dihydroxyacetone kinase subunit M YP_003044388.1 1247846 R 413997 CDS YP_003044389.1 254161281 8175914 complement(1249275..1249907) 1 NC_012967.1 with DhaK and DhaM catalyzes the phosphorylation of dihydroxyacetone; dihydroxyacetone kinase subunit DhaL 1249907 dhaL 8175914 dhaL Escherichia coli B str. REL606 dihydroxyacetone kinase subunit DhaL YP_003044389.1 1249275 R 413997 CDS YP_003044390.1 254161282 8178449 complement(1249918..1250988) 1 NC_012967.1 with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase; dihydroxyacetone kinase subunit DhaK 1250988 dhaK 8178449 dhaK Escherichia coli B str. REL606 dihydroxyacetone kinase subunit DhaK YP_003044390.1 1249918 R 413997 CDS YP_003044391.1 254161283 8175915 1251216..1253135 1 NC_012967.1 Positively regulates the dhaKLM operon from a sigma-70 promoter; DNA-binding transcriptional regulator DhaR 1253135 dhaR 8175915 dhaR Escherichia coli B str. REL606 DNA-binding transcriptional regulator DhaR YP_003044391.1 1251216 D 413997 CDS YP_003044392.1 254161284 8175916 complement(1253235..1256102) 1 NC_012967.1 similar to b1202; putative adhesin 1256102 ycgV 8175916 ycgV Escherichia coli B str. REL606 putative adhesin YP_003044392.1 1253235 R 413997 CDS YP_003044393.1 254161285 8178450 complement(1256871..1257962) 1 NC_012967.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 1257962 ychF 8178450 ychF Escherichia coli B str. REL606 GTP-dependent nucleic acid-binding protein EngD YP_003044393.1 1256871 R 413997 CDS YP_003044394.1 254161286 8175917 complement(1258079..1258663) 1 NC_012967.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 1258663 pth 8175917 pth Escherichia coli B str. REL606 peptidyl-tRNA hydrolase YP_003044394.1 1258079 R 413997 CDS YP_003044395.1 254161287 8179004 1258941..1259219 1 NC_012967.1 YchH; transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria; ychH presents a class II promoter to bind CRP; unknown function; hypothetical protein 1259219 ychH 8179004 ychH Escherichia coli B str. REL606 hypothetical protein YP_003044395.1 1258941 D 413997 CDS YP_003044396.1 254161288 8175918 complement(1259274..1260953) 1 NC_012967.1 putative role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport; putative sulfate transporter YchM 1260953 ychM 8175918 ychM Escherichia coli B str. REL606 putative sulfate transporter YchM YP_003044396.1 1259274 R 413997 CDS YP_003044397.1 254161289 8175919 complement(1261078..1262025) 1 NC_012967.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 1262025 prsA 8175919 prsA Escherichia coli B str. REL606 ribose-phosphate pyrophosphokinase YP_003044397.1 1261078 R 413997 CDS YP_003044398.1 254161290 8175920 complement(1262176..1263027) 1 NC_012967.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 1263027 ipk 8175920 ipk Escherichia coli B str. REL606 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase YP_003044398.1 1262176 R 413997 CDS YP_003044399.1 254161291 8175921 complement(1263027..1263650) 1 NC_012967.1 Incorporates lipoproteins in the outer membrane after they are released by the LolA protein; outer membrane lipoprotein LolB 1263650 lolB 8175921 lolB Escherichia coli B str. REL606 outer membrane lipoprotein LolB YP_003044399.1 1263027 R 413997 CDS YP_003044400.1 254161292 8179005 1263864..1265120 1 NC_012967.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 1265120 hemA 8179005 hemA Escherichia coli B str. REL606 glutamyl-tRNA reductase YP_003044400.1 1263864 D 413997 CDS YP_003044401.1 254161293 8175922 1265162..1266244 1 NC_012967.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 1266244 prfA 8175922 prfA Escherichia coli B str. REL606 peptide chain release factor 1 YP_003044401.1 1265162 D 413997 CDS YP_003044402.1 254161294 8179006 1266244..1267077 1 NC_012967.1 HemK; PrmC; transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 1267077 hemK 8179006 hemK Escherichia coli B str. REL606 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase YP_003044402.1 1266244 D 413997 CDS YP_003044403.1 254161295 8175923 1267074..1267466 1 NC_012967.1 similar to b1213; putative transcriptional regulator 1267466 ychQ 8175923 ychQ Escherichia coli B str. REL606 putative transcriptional regulator YP_003044403.1 1267074 D 413997 CDS YP_003044404.1 254161296 8175924 1267470..1268279 1 NC_012967.1 similar to b1214; putative transcriptional regulator 1268279 ychA 8175924 ychA Escherichia coli B str. REL606 putative transcriptional regulator YP_003044404.1 1267470 D 413997 CDS YP_003044405.1 254161297 8178451 1268315..1269169 1 NC_012967.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 1269169 kdsA 8178451 kdsA Escherichia coli B str. REL606 2-dehydro-3-deoxyphosphooctonate aldolase YP_003044405.1 1268315 D 413997 CDS YP_003044406.1 254161298 8175925 complement(1269316..1269423) 1 NC_012967.1 similar to b4419; toxic polypeptide, small 1269423 ldrA 8175925 ldrA Escherichia coli B str. REL606 toxic polypeptide, small YP_003044406.1 1269316 R 413997 CDS YP_003044407.1 254161299 8179007 complement(1269851..1269958) 1 NC_012967.1 similar to b4421; toxic polypeptide, small 1269958 ldrB 8179007 ldrB Escherichia coli B str. REL606 toxic polypeptide, small YP_003044407.1 1269851 R 413997 CDS YP_003044408.1 254161300 8175926 complement(1270386..1270493) 1 NC_012967.1 similar to b4423; toxic polypeptide, small 1270493 ldrC 8175926 ldrC Escherichia coli B str. REL606 toxic polypeptide, small YP_003044408.1 1270386 R 413997 CDS YP_003044409.1 254161301 8175927 complement(1270898..1271998) 1 NC_012967.1 similar to b1216; calcium/sodium:proton antiporter 1271998 chaA 8175927 chaA Escherichia coli B str. REL606 calcium/sodium:proton antiporter YP_003044409.1 1270898 R 413997 CDS YP_003044410.1 254161302 8175928 1272268..1272498 1 NC_012967.1 in Escherichia coli this protein putatively regulates the sodium/proton (also pH-independent calcium/proton) antiporter chaA; has weak affinity for calcium and magnesium ions; cation transport regulator 1272498 chaB 8175928 chaB Escherichia coli B str. REL606 cation transport regulator YP_003044410.1 1272268 D 413997 CDS YP_003044411.1 254161303 8175929 1272635..1273351 1 NC_012967.1 similar to b1218; regulatory protein for cation transport 1273351 chaC 8175929 chaC Escherichia coli B str. REL606 regulatory protein for cation transport YP_003044411.1 1272635 D 413997 CDS YP_003044412.1 254161304 8179008 complement(1273395..1273748) 1 NC_012967.1 similar to b1219; hypothetical protein 1273748 ychN 8179008 ychN Escherichia coli B str. REL606 hypothetical protein YP_003044412.1 1273395 R 413997 CDS YP_003044413.1 254161305 8175930 1274075..1275328 1 NC_012967.1 similar to b1220; hypothetical protein 1275328 ychP 8175930 ychP Escherichia coli B str. REL606 hypothetical protein YP_003044413.1 1274075 D 413997 CDS YP_003044414.1 254161306 8175931 complement(1275329..1275979) 1 NC_012967.1 two-component response regulator NarL; phosphorylated by NarQ; activates transcription of nitrate and nitrite reductase genes and represses transcription of fumarate reductase; transcriptional regulator NarL 1275979 narL 8175931 narL Escherichia coli B str. REL606 transcriptional regulator NarL YP_003044414.1 1275329 R 413997 CDS YP_003044415.1 254161307 8175932 complement(1275972..1277768) 1 NC_012967.1 similar to b1222; nitrate/nitrite sensor protein NarX 1277768 narX 8175932 narX Escherichia coli B str. REL606 nitrate/nitrite sensor protein NarX YP_003044415.1 1275972 R 413997 CDS YP_003044416.1 254161308 8175933 1278107..1279498 1 NC_012967.1 similar to b1223; nitrate/nitrite transporter 1279498 narK 8175933 narK Escherichia coli B str. REL606 nitrate/nitrite transporter YP_003044416.1 1278107 D 413997 CDS YP_003044417.1 254161309 8175934 1280014..1283757 1 NC_012967.1 similar to b1224; nitrate reductase 1, subunit alpha 1283757 narG 8175934 narG Escherichia coli B str. REL606 nitrate reductase 1, subunit alpha YP_003044417.1 1280014 D 413997 CDS YP_003044418.1 254161310 8175935 1283754..1285292 1 NC_012967.1 similar to b1225; nitrate reductase 1, beta (Fe-S) subunit 1285292 narH 8175935 narH Escherichia coli B str. REL606 nitrate reductase 1, beta (Fe-S) subunit YP_003044418.1 1283754 D 413997 CDS YP_003044419.1 254161311 8175936 1285289..1285999 1 NC_012967.1 similar to b1226; molybdenum-cofactor-assembly chaperone subunit (subunit delta) of nitrate reductase 1 1285999 narJ 8175936 narJ Escherichia coli B str. REL606 molybdenum-cofactor-assembly chaperone subunit (subunit delta) of nitrate reductase 1 YP_003044419.1 1285289 D 413997 CDS YP_003044420.1 254161312 8179009 1285999..1286676 1 NC_012967.1 similar to b1227; nitrate reductase 1, gamma (cytochrome b(NR)) subunit 1286676 narI 8179009 narI Escherichia coli B str. REL606 nitrate reductase 1, gamma (cytochrome b(NR)) subunit YP_003044420.1 1285999 D 413997 CDS YP_003044421.1 254161313 8175940 complement(1287576..1288418) 1 NC_012967.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; formyltetrahydrofolate deformylase 1288418 purU 8175940 purU Escherichia coli B str. REL606 formyltetrahydrofolate deformylase YP_003044421.1 1287576 R 413997 CDS YP_003044422.1 254161314 8175941 complement(1288468..1288926) 1 NC_012967.1 similar to b1233; hypothetical protein 1288926 ychJ 8175941 ychJ Escherichia coli B str. REL606 hypothetical protein YP_003044422.1 1288468 R 413997 CDS YP_003044423.1 254161315 8175942 1289000..1289944 1 NC_012967.1 similar to b1234; hypothetical protein 1289944 ychK 8175942 ychK Escherichia coli B str. REL606 hypothetical protein YP_003044423.1 1289000 D 413997 CDS YP_003044424.1 254161316 8175943 1290036..1291049 1 NC_012967.1 similar to b1235; response regulator of RpoS 1291049 hnr 8175943 hnr Escherichia coli B str. REL606 response regulator of RpoS YP_003044424.1 1290036 D 413997 CDS YP_003044425.1 254161317 8178452 1291251..1292159 1 NC_012967.1 together with GalF subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; UTP--glucose-1-phosphate uridylyltransferase subunit GalU 1292159 galU 8178452 galU Escherichia coli B str. REL606 UTP--glucose-1-phosphate uridylyltransferase subunit GalU YP_003044425.1 1291251 D 413997 CDS YP_003044426.1 254161318 8175944 complement(1292303..1292716) 1 NC_012967.1 similar to b1237; global DNA-binding transcriptional dual regulator H-NS 1292716 hns 8175944 hns Escherichia coli B str. REL606 global DNA-binding transcriptional dual regulator H-NS YP_003044426.1 1292303 R 413997 CDS YP_003044427.1 254161319 8178453 1293320..1293937 1 NC_012967.1 catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 1293937 tdk 8178453 tdk Escherichia coli B str. REL606 thymidine kinase YP_003044427.1 1293320 D 413997 CDS YP_003044428.1 254161320 8175945 complement(1294239..1296914) 1 NC_012967.1 similar to b1241; bifunctional acetaldehyde-CoA/alcohol dehydrogenase 1296914 adhE 8175945 adhE Escherichia coli B str. REL606 bifunctional acetaldehyde-CoA/alcohol dehydrogenase YP_003044428.1 1294239 R 413997 CDS YP_003044429.1 254161321 8175946 1297391..1298038 1 NC_012967.1 similar to b1242; hypothetical protein 1298038 ychE 8175946 ychE Escherichia coli B str. REL606 hypothetical protein YP_003044429.1 1297391 D 413997 CDS YP_003044430.1 254161322 8178454 1298776..1300407 1 NC_012967.1 similar to b1243; oligopeptide transporter subunit 1300407 oppA 8178454 oppA Escherichia coli B str. REL606 oligopeptide transporter subunit YP_003044430.1 1298776 D 413997 CDS YP_003044431.1 254161323 8175947 1300493..1301413 1 NC_012967.1 similar to b1244; oligopeptide transporter permease 1301413 oppB 8175947 oppB Escherichia coli B str. REL606 oligopeptide transporter permease YP_003044431.1 1300493 D 413997 CDS YP_003044432.1 254161324 8175948 1301428..1302336 1 NC_012967.1 similar to b1245; oligopeptide transporter subunit 1302336 oppC 8175948 oppC Escherichia coli B str. REL606 oligopeptide transporter subunit YP_003044432.1 1301428 D 413997 CDS YP_003044433.1 254161325 8175949 1302348..1303361 1 NC_012967.1 similar to b1246; oligopeptide transporter ATP-binding protein 1303361 oppD 8175949 oppD Escherichia coli B str. REL606 oligopeptide transporter ATP-binding protein YP_003044433.1 1302348 D 413997 CDS YP_003044434.1 254161326 8175950 1303358..1304362 1 NC_012967.1 similar to b1247; oligopeptide transporter subunit 1304362 oppF 8175950 oppF Escherichia coli B str. REL606 oligopeptide transporter subunit YP_003044434.1 1303358 D 413997 CDS YP_003044435.1 254161327 8175951 complement(1304415..1304744) 1 NC_012967.1 highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein; dsDNA-mimic protein 1304744 yciU 8175951 yciU Escherichia coli B str. REL606 dsDNA-mimic protein YP_003044435.1 1304415 R 413997 CDS YP_003044436.1 254161328 8175952 complement(1304779..1306239) 1 NC_012967.1 catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol); cardiolipin synthetase 1306239 cls 8175952 cls Escherichia coli B str. REL606 cardiolipin synthetase YP_003044436.1 1304779 R 413997 CDS YP_003044437.1 254161329 8178455 complement(1306610..1307863) 1 NC_012967.1 similar to b1250; voltage-gated potassium channel 1307863 kch 8178455 kch Escherichia coli B str. REL606 voltage-gated potassium channel YP_003044437.1 1306610 R 413997 CDS YP_003044438.1 254161330 8175953 complement(1308163..1308459) 1 NC_012967.1 unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity; YciI-like protein 1308459 yciI 8175953 yciI Escherichia coli B str. REL606 YciI-like protein YP_003044438.1 1308163 R 413997 CDS YP_003044439.1 254161331 8178456 1308683..1309402 1 NC_012967.1 membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins; transport protein TonB 1309402 tonB 8178456 tonB Escherichia coli B str. REL606 transport protein TonB YP_003044439.1 1308683 D 413997 CDS YP_003044440.1 254161332 8175954 complement(1309442..1309840) 1 NC_012967.1 YciA; hydrolase that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA; member of the the acyl coenzyme A hydrolase family of proteins; acyl-CoA thioester hydrolase 1309840 yciA 8175954 yciA Escherichia coli B str. REL606 acyl-CoA thioester hydrolase YP_003044440.1 1309442 R 413997 CDS YP_003044441.1 254161333 8175955 complement(1309945..1310484) 1 NC_012967.1 Involved in cell division; probably involved in intracellular septation; intracellular septation protein A 1310484 ispZ 8175955 ispZ Escherichia coli B str. REL606 intracellular septation protein A YP_003044441.1 1309945 R 413997 CDS YP_003044442.1 254161334 8178457 complement(1310514..1311257) 1 NC_012967.1 similar to b1255; hypothetical protein 1311257 yciC 8178457 yciC Escherichia coli B str. REL606 hypothetical protein YP_003044442.1 1310514 R 413997 CDS YP_003044443.1 254161335 8175956 1311614..1312252 1 NC_012967.1 receptor for colicin S4; outer membrane protein W 1312252 yciD 8175956 yciD Escherichia coli B str. REL606 outer membrane protein W YP_003044443.1 1311614 D 413997 CDS YP_003044444.1 254161336 8179010 complement(1312312..1312818) 1 NC_012967.1 similar to b1257; hypothetical protein 1312818 yciE 8179010 yciE Escherichia coli B str. REL606 hypothetical protein YP_003044444.1 1312312 R 413997 CDS YP_003044445.1 254161337 8175957 complement(1312864..1313364) 1 NC_012967.1 similar to b1258; hypothetical protein 1313364 yciF 8175957 yciF Escherichia coli B str. REL606 hypothetical protein YP_003044445.1 1312864 R 413997 CDS YP_003044446.1 254161338 8175958 complement(1313450..1313629) 1 NC_012967.1 similar to b1259; hypothetical protein 1313629 yciG 8175958 yciG Escherichia coli B str. REL606 hypothetical protein YP_003044446.1 1313450 R 413997 CDS YP_003044447.1 254161339 8175959 complement(1314010..1314816) 1 NC_012967.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 1314816 trpA 8175959 trpA Escherichia coli B str. REL606 tryptophan synthase subunit alpha YP_003044447.1 1314010 R 413997 CDS YP_003044448.1 254161340 8175960 complement(1314816..1316009) 1 NC_012967.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 1316009 trpB 8175960 trpB Escherichia coli B str. REL606 tryptophan synthase subunit beta YP_003044448.1 1314816 R 413997 CDS YP_003044449.1 254161341 8178458 complement(1316021..1317379) 1 NC_012967.1 monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate; bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase 1317379 trpC 8178458 trpC Escherichia coli B str. REL606 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase YP_003044449.1 1316021 R 413997 CDS YP_003044450.1 254161342 8175961 complement(1317383..1318978) 1 NC_012967.1 bifunctional anthranilate synthase II/anthranilate phosphoribosyltransferase; TrpD; forms a heterotetramer with Trp E and the complex catalyzes the formation of anthranilate from chorismate and glutamine; also catalyzes the formation of N-(5-phospho-D-ribosyl)-anthranilate from athranilate and 5-phospho-alpha-D-ribose 1-diphosphate; functions in tryptophan biosynthesis; bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase 1318978 trpD 8175961 trpD Escherichia coli B str. REL606 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase YP_003044450.1 1317383 R 413997 CDS YP_003044451.1 254161343 8179011 complement(1318978..1320540) 1 NC_012967.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 1320540 trpE 8179011 trpE Escherichia coli B str. REL606 anthranilate synthase component I YP_003044451.1 1318978 R 413997 CDS YP_003044453.1 254161345 8175963 1320814..1321695 1 NC_012967.1 similar to b1266; hypothetical protein 1321695 yciV 8175963 yciV Escherichia coli B str. REL606 hypothetical protein YP_003044453.1 1320814 D 413997 CDS YP_003044454.1 254161346 8175964 1321692..1322312 1 NC_012967.1 similar to b1267; hypothetical protein 1322312 yciO 8175964 yciO Escherichia coli B str. REL606 hypothetical protein YP_003044454.1 1321692 D 413997 CDS YP_003044455.1 254161347 8175966 1322776..1323051 1 NC_012967.1 IS1 protein InsA 1323051 insA-11 8175966 insA-11 Escherichia coli B str. REL606 IS1 protein InsA YP_003044455.1 1322776 D 413997 CDS YP_003044456.1 254161348 8175967 1322970..1323473 1 NC_012967.1 IS1 protein InsA 1323473 insB-11 8175967 insB-11 Escherichia coli B str. REL606 IS1 protein InsA YP_003044456.1 1322970 D 413997 CDS YP_003044457.1 254161349 8175968 1325224..1326099 1 NC_012967.1 catalyzes the synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA; 23S rRNA pseudouridylate synthase B 1326099 yciL 8175968 yciL Escherichia coli B str. REL606 23S rRNA pseudouridylate synthase B YP_003044457.1 1325224 D 413997 CDS YP_003044458.1 254161350 8178459 complement(1326139..1326729) 1 NC_012967.1 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide; cob(I)yrinic acid a,c-diamide adenosyltransferase 1326729 btuR 8178459 btuR Escherichia coli B str. REL606 cob(I)yrinic acid a,c-diamide adenosyltransferase YP_003044458.1 1326139 R 413997 CDS YP_003044459.1 254161351 8175969 complement(1326726..1327484) 1 NC_012967.1 similar to b1271; short chain dehydrogenase 1327484 yciK 8175969 yciK Escherichia coli B str. REL606 short chain dehydrogenase YP_003044459.1 1326726 R 413997 CDS YP_003044460.1 254161352 8175970 1327704..1328753 1 NC_012967.1 SohB; periplasmic protein; member of the peptidase S49 family; putative periplasmic protease 1328753 sohB 8175970 sohB Escherichia coli B str. REL606 putative periplasmic protease YP_003044460.1 1327704 D 413997 CDS YP_003044461.1 254161353 8175971 complement(1328789..1329040) 1 NC_012967.1 similar to b1273; hypothetical protein 1329040 yciN 8175971 yciN Escherichia coli B str. REL606 hypothetical protein YP_003044461.1 1328789 R 413997 CDS YP_003044462.1 254161354 8175972 1329420..1332017 1 NC_012967.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 1332017 topA 8175972 topA Escherichia coli B str. REL606 DNA topoisomerase I YP_003044462.1 1329420 D 413997 CDS YP_003044463.1 254161355 8175973 1332227..1333201 1 NC_012967.1 LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation; transcriptional regulator CysB 1333201 cysB 8175973 cysB Escherichia coli B str. REL606 transcriptional regulator CysB YP_003044463.1 1332227 D 413997 CDS YP_003044464.1 254161356 8179012 1334203..1336878 1 NC_012967.1 Catalyzes the conversion of citrate to isocitrate; aconitate hydratase 1336878 acnA 8179012 acnA Escherichia coli B str. REL606 aconitate hydratase YP_003044464.1 1334203 D 413997 CDS YP_003044465.1 254161357 8175975 complement(1336942..1337532) 1 NC_012967.1 catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate; GTP cyclohydrolase II 1337532 ribA 8175975 ribA Escherichia coli B str. REL606 GTP cyclohydrolase II YP_003044465.1 1336942 R 413997 CDS YP_003044466.1 254161358 8175976 1337702..1338466 1 NC_012967.1 similar to b1278; phosphatidylglycerophosphatase B 1338466 pgpB 8175976 pgpB Escherichia coli B str. REL606 phosphatidylglycerophosphatase B YP_003044466.1 1337702 D 413997 CDS YP_003044467.1 254161359 8178460 1338615..1338923 1 NC_012967.1 similar to b1279; inner membrane protein 1338923 yciS 8178460 yciS Escherichia coli B str. REL606 inner membrane protein YP_003044467.1 1338615 D 413997 CDS YP_003044468.1 254161360 8175977 1338930..1340099 1 NC_012967.1 similar to b1280; tetratricopeptide repeat protein 1340099 yciM 8175977 yciM Escherichia coli B str. REL606 tetratricopeptide repeat protein YP_003044468.1 1338930 D 413997 CDS YP_003044469.1 254161361 8175978 1340292..1341029 1 NC_012967.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 1341029 pyrF 8175978 pyrF Escherichia coli B str. REL606 orotidine 5'-phosphate decarboxylase YP_003044469.1 1340292 D 413997 CDS YP_003044470.1 254161362 8178461 1341029..1341355 1 NC_012967.1 involved in start site selection during the initiation of translation; translation initiation factor Sui1 1341355 yciH 8178461 yciH Escherichia coli B str. REL606 translation initiation factor Sui1 YP_003044470.1 1341029 D 413997 CDS YP_003044471.1 254161363 8175979 complement(1341481..1341699) 1 NC_012967.1 similar to b1283; lipoprotein 1341699 osmB 8175979 osmB Escherichia coli B str. REL606 lipoprotein YP_003044471.1 1341481 R 413997 CDS YP_003044472.1 254161364 8175980 complement(1341968..1342717) 1 NC_012967.1 similar to b1284; putative DNA-binding transcriptional regulator 1342717 yciT 8175980 yciT Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003044472.1 1341968 R 413997 CDS YP_003044473.1 254161365 8175981 complement(1343127..1345112) 1 NC_012967.1 c-di-GMP phosphodiesterase; probably degrades signalling molecule c-di-GMP; RNase II stability modulator 1345112 yciR 8175981 yciR Escherichia coli B str. REL606 RNase II stability modulator YP_003044473.1 1343127 R 413997 CDS YP_003044474.1 254161366 8178462 complement(1345347..1347281) 1 NC_012967.1 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction; exoribonuclease II 1347281 rnb 8178462 rnb Escherichia coli B str. REL606 exoribonuclease II YP_003044474.1 1345347 R 413997 CDS YP_003044475.1 254161367 8175982 complement(1347349..1348476) 1 NC_012967.1 similar to b1287; putative oxidoreductase 1348476 yciW 8175982 yciW Escherichia coli B str. REL606 putative oxidoreductase YP_003044475.1 1347349 R 413997 CDS YP_003044476.1 254161368 8175983 complement(1348620..1349408) 1 NC_012967.1 Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-(acyl carrier protein) reductase 1349408 fabI 8175983 fabI Escherichia coli B str. REL606 enoyl-(acyl carrier protein) reductase YP_003044476.1 1348620 R 413997 CDS YP_003044477.1 254161369 8178463 complement(1349776..1350129) 1 NC_012967.1 similar to b1289; hypothetical protein 1350129 ycjD 8178463 ycjD Escherichia coli B str. REL606 hypothetical protein YP_003044477.1 1349776 R 413997 CDS YP_003044478.1 254161370 8175984 complement(1350197..1351003) 1 NC_012967.1 similar to b1290; putative antimicrobial peptide transporter subunit 1351003 sapF 8175984 sapF Escherichia coli B str. REL606 putative antimicrobial peptide transporter subunit YP_003044478.1 1350197 R 413997 CDS YP_003044479.1 254161371 8175985 complement(1351005..1351997) 1 NC_012967.1 similar to b1291; putative antimicrobial peptide transporter subunit 1351997 sapD 8175985 sapD Escherichia coli B str. REL606 putative antimicrobial peptide transporter subunit YP_003044479.1 1351005 R 413997 CDS YP_003044480.1 254161372 8175986 complement(1351997..1352887) 1 NC_012967.1 similar to b1292; putative antimicrobial peptide transporter subunit 1352887 sapC 8175986 sapC Escherichia coli B str. REL606 putative antimicrobial peptide transporter subunit YP_003044480.1 1351997 R 413997 CDS YP_003044481.1 254161373 8179013 complement(1352874..1353839) 1 NC_012967.1 similar to b1293; putative antimicrobial peptide transporter subunit 1353839 sapB 8179013 sapB Escherichia coli B str. REL606 putative antimicrobial peptide transporter subunit YP_003044481.1 1352874 R 413997 CDS YP_003044482.1 254161374 8175987 complement(1353836..1355479) 1 NC_012967.1 similar to b1294; putative antimicrobial peptide transporter subunit 1355479 sapA 8175987 sapA Escherichia coli B str. REL606 putative antimicrobial peptide transporter subunit YP_003044482.1 1353836 R 413997 CDS YP_003044483.1 254161375 8175988 complement(1355791..1356036) 1 NC_012967.1 similar to b1295; hypothetical protein 1356036 ymjA 8175988 ymjA Escherichia coli B str. REL606 hypothetical protein YP_003044483.1 1355791 R 413997 CDS YP_003044484.1 254161376 8179014 complement(1356170..1357555) 1 NC_012967.1 similar to b1296; putrescine importer 1357555 ycjJ 8179014 ycjJ Escherichia coli B str. REL606 putrescine importer YP_003044484.1 1356170 R 413997 CDS YP_003044485.1 254161377 8175989 complement(1357858..1359276) 1 NC_012967.1 similar to b1297; gamma-Glu-putrescine synthase 1359276 ycjK 8175989 ycjK Escherichia coli B str. REL606 gamma-Glu-putrescine synthase YP_003044485.1 1357858 R 413997 CDS YP_003044486.1 254161378 8175990 1359488..1360252 1 NC_012967.1 catalyzes the degradation of gamma-glutamyl-gamma-aminobutyrate into glutamate and gamma-aminobutyrate; gamma-glutamyl-gamma-aminobutyrate hydrolase 1360252 puuD 8175990 puuD Escherichia coli B str. REL606 gamma-glutamyl-gamma-aminobutyrate hydrolase YP_003044486.1 1359488 D 413997 CDS YP_003044487.1 254161379 8178464 1360279..1360836 1 NC_012967.1 regulates genes involved in putrescine degradation; DNA-binding transcriptional repressor PuuR 1360836 ycjC 8178464 ycjC Escherichia coli B str. REL606 DNA-binding transcriptional repressor PuuR YP_003044487.1 1360279 D 413997 CDS YP_003044488.1 254161380 8175991 1361111..1362598 1 NC_012967.1 catalyzes the formation of gamma-glutamyl-gamma-aminobutyrate from Gamma-glutamyl-gamma-aminobutyraldehyde; involved in putrescine degradation; gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase 1362598 aldH 8175991 aldH Escherichia coli B str. REL606 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase YP_003044488.1 1361111 D 413997 CDS YP_003044489.1 254161381 8179015 1362600..1363880 1 NC_012967.1 similar to b1301; gamma-Glu-putrescine oxidase, FAD/NAD(P)-binding 1363880 ordL 8179015 ordL Escherichia coli B str. REL606 gamma-Glu-putrescine oxidase, FAD/NAD(P)-binding YP_003044489.1 1362600 D 413997 CDS YP_003044490.1 254161382 8175992 1363918..1365183 1 NC_012967.1 putrescine-inducible GABA aminotransferase; catalyzes the formation of glutamate and succinate semialdehyde from 4-aminobutyrate and 2-oxoglutarate; 4-aminobutyrate transaminase 1365183 goaG 8175992 goaG Escherichia coli B str. REL606 4-aminobutyrate transaminase YP_003044490.1 1363918 D 413997 CDS YP_003044491.1 254161383 8175993 complement(1365303..1366280) 1 NC_012967.1 transcriptional activator for pspABCE which are induced in response to phage proteins, membrane altering stresses, and impaired proton expor; phage shock protein operon transcriptional activator 1366280 pspF 8175993 pspF Escherichia coli B str. REL606 phage shock protein operon transcriptional activator YP_003044491.1 1365303 R 413997 CDS YP_003044492.1 254161384 8179016 1366447..1367115 1 NC_012967.1 involved in maintaining membrane potential under membrane stress conditions; also acts as a negative transcriptional regulator of the phage shock protein (psp) operon(pspABCDE) by regulating the transcriptional activator PspF; phage shock protein PspA 1367115 pspA 8179016 pspA Escherichia coli B str. REL606 phage shock protein PspA YP_003044492.1 1366447 D 413997 CDS YP_003044493.1 254161385 8175994 1367169..1367393 1 NC_012967.1 acts together with PspC to induce psp operon during infection with phage, exposure to ethanol or osmotic shock; forms a complex with PspA and C; PspC is required for PspAB binding; phage shock protein B 1367393 pspB 8175994 pspB Escherichia coli B str. REL606 phage shock protein B YP_003044493.1 1367169 D 413997 CDS YP_003044494.1 254161386 8175995 1367393..1367752 1 NC_012967.1 with PsbB forms toxin/antitoxin pair; activates the psp operon in response to phage infection, exposure to ethanol or osmotic shock; DNA-binding transcriptional activator PspC 1367752 pspC 8175995 pspC Escherichia coli B str. REL606 DNA-binding transcriptional activator PspC YP_003044494.1 1367393 D 413997 CDS YP_003044495.1 254161387 8178465 1367761..1367982 1 NC_012967.1 similar to b1307; peripheral inner membrane phage-shock protein 1367982 pspD 8178465 pspD Escherichia coli B str. REL606 peripheral inner membrane phage-shock protein YP_003044495.1 1367761 D 413997 CDS YP_003044496.1 254161388 8175996 1368057..1368371 1 NC_012967.1 rhodanese; catalyzes the formation of thiocyanate from thiosulfate and hydrogen cyanide; thiosulfate:cyanide sulfurtransferase 1368371 pspE 8175996 pspE Escherichia coli B str. REL606 thiosulfate:cyanide sulfurtransferase YP_003044496.1 1368057 D 413997 CDS YP_003044497.1 254161389 8175997 1368584..1370263 1 NC_012967.1 similar to b1309; putative glucosyltransferase 1370263 ycjM 8175997 ycjM Escherichia coli B str. REL606 putative glucosyltransferase YP_003044497.1 1368584 D 413997 CDS YP_003044498.1 254161390 8175998 1370277..1371569 1 NC_012967.1 similar to b1310; putative sugar transporter subunit periplasmic-binding component of ABC superfamily 1371569 ycjN 8175998 ycjN Escherichia coli B str. REL606 putative sugar transporter subunit periplasmic-binding component of ABC superfamily YP_003044498.1 1370277 D 413997 CDS YP_003044499.1 254161391 8175999 1371590..1372471 1 NC_012967.1 similar to b1311; putative sugar transporter subunit membrane component of ABC superfamily 1372471 ycjO 8175999 ycjO Escherichia coli B str. REL606 putative sugar transporter subunit membrane component of ABC superfamily YP_003044499.1 1371590 D 413997 CDS YP_003044500.1 254161392 8176000 1372458..1373300 1 NC_012967.1 similar to b1312; putative sugar transporter subunit membrane component of ABC superfamily 1373300 ycjP 8176000 ycjP Escherichia coli B str. REL606 putative sugar transporter subunit membrane component of ABC superfamily YP_003044500.1 1372458 D 413997 CDS YP_003044501.1 254161393 8176001 1373331..1374383 1 NC_012967.1 similar to b1313; putative oxidoreductase, Zn-dependent and NAD(P)-binding 1374383 ycjQ 8176001 ycjQ Escherichia coli B str. REL606 putative oxidoreductase, Zn-dependent and NAD(P)-binding YP_003044501.1 1373331 D 413997 CDS YP_003044502.1 254161394 8179017 1374402..1375190 1 NC_012967.1 similar to b1314; hypothetical protein 1375190 ycjR 8179017 ycjR Escherichia coli B str. REL606 hypothetical protein YP_003044502.1 1374402 D 413997 CDS YP_003044503.1 254161395 8176002 1375200..1376255 1 NC_012967.1 similar to b1315; putative oxidoreductase, NADH-binding 1376255 ycjS 8176002 ycjS Escherichia coli B str. REL606 putative oxidoreductase, NADH-binding YP_003044503.1 1375200 D 413997 CDS YP_003044504.1 254161396 8176003 1376252..1378519 1 NC_012967.1 similar to b1316; putative hydrolase 1378519 ycjT 8176003 ycjT Escherichia coli B str. REL606 putative hydrolase YP_003044504.1 1376252 D 413997 CDS YP_003044505.1 254161397 8176004 1378516..1379175 1 NC_012967.1 similar to b1317; putative beta-phosphoglucomutase 1379175 ycjU 8176004 ycjU Escherichia coli B str. REL606 putative beta-phosphoglucomutase YP_003044505.1 1378516 D 413997 CDS YP_003044506.1 254161398 8176005 1379189..1380271 1 NC_012967.1 similar to b1318; extended C-terminal; pseudo in K-12MG1655; putative sugar transport protein 1380271 ycjV 8176005 ycjV Escherichia coli B str. REL606 putative sugar transport protein YP_003044506.1 1379189 D 413997 CDS YP_003044507.1 254161399 8176006 1380316..1381221 1 NC_012967.1 similar to b1319; outer membrane porin 1381221 ompG 8176006 ompG Escherichia coli B str. REL606 outer membrane porin YP_003044507.1 1380316 D 413997 CDS YP_003044508.1 254161400 8176007 complement(1381332..1382330) 1 NC_012967.1 similar to b1320; putative DNA-binding transcriptional regulator 1382330 ycjW 8176007 ycjW Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003044508.1 1381332 R 413997 CDS YP_003044509.1 254161401 8179018 1382486..1383883 1 NC_012967.1 similar to b1321; hypothetical protein 1383883 ycjX 8179018 ycjX Escherichia coli B str. REL606 hypothetical protein YP_003044509.1 1382486 D 413997 CDS YP_003044510.1 254161402 8176008 1383880..1384941 1 NC_012967.1 similar to b1322; hypothetical protein 1384941 ycjF 8176008 ycjF Escherichia coli B str. REL606 hypothetical protein YP_003044510.1 1383880 D 413997 CDS YP_003044511.1 254161403 8176009 1385089..1386630 1 NC_012967.1 regulates genes involved in the biosynthesis and transport of aromatic amino acids; DNA-binding transcriptional regulator TyrR 1386630 tyrR 8176009 tyrR Escherichia coli B str. REL606 DNA-binding transcriptional regulator TyrR YP_003044511.1 1385089 D 413997 CDS YP_003044512.1 254161404 8176010 complement(1386674..1387180) 1 NC_012967.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 1387180 tpx 8176010 tpx Escherichia coli B str. REL606 thiol peroxidase YP_003044512.1 1386674 R 413997 CDS YP_003044513.1 254161405 8176011 1387299..1388264 1 NC_012967.1 similar to b1325; L-Ala-D/L-Glu epimerase 1388264 ycjG 8176011 ycjG Escherichia coli B str. REL606 L-Ala-D/L-Glu epimerase YP_003044513.1 1387299 D 413997 CDS YP_003044514.1 254161406 8178466 complement(1388239..1389027) 1 NC_012967.1 similar to b1326; murein peptide amidase A 1389027 ycjI 8178466 ycjI Escherichia coli B str. REL606 murein peptide amidase A YP_003044514.1 1388239 R 413997 CDS YP_003044515.1 254161407 8176013 complement(1389302..1390234) 1 NC_012967.1 similar to b1327; putative hydrolase 1390234 ycjY 8176013 ycjY Escherichia coli B str. REL606 putative hydrolase YP_003044515.1 1389302 R 413997 CDS YP_003044516.1 254161408 8178467 1390360..1391259 1 NC_012967.1 similar to b1328; putative DNA-binding transcriptional regulator 1391259 ycjZ 8178467 ycjZ Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003044516.1 1390360 D 413997 CDS YP_003044517.1 254161409 8176014 1391596..1393209 1 NC_012967.1 similar to b1329; murein tripeptide (L-ala-gamma-D-glutamyl-meso-DAP) transporter subunit 1393209 mppA 8176014 mppA Escherichia coli B str. REL606 murein tripeptide (L-ala-gamma-D-glutamyl-meso-DAP) transporter subunit YP_003044517.1 1391596 D 413997 CDS YP_003044518.1 254161410 8176015 complement(1393260..1394291) 1 NC_012967.1 similar to b1330; inner membrane protein 1394291 ynaI 8176015 ynaI Escherichia coli B str. REL606 inner membrane protein YP_003044518.1 1393260 R 413997 CDS YP_003044519.1 254161411 8176016 1394535..1394792 1 NC_012967.1 similar to b1332; putative inner membrane protein 1394792 ynaJ 8176016 ynaJ Escherichia coli B str. REL606 putative inner membrane protein YP_003044519.1 1394535 D 413997 CDS YP_003044520.1 254161412 8176017 complement(1394842..1395792) 1 NC_012967.1 with UspC and UspD is involved in resistance to UV irradiation; universal stress protein UspE 1395792 ydaA 8176017 ydaA Escherichia coli B str. REL606 universal stress protein UspE YP_003044520.1 1394842 R 413997 CDS YP_003044521.1 254161413 8179019 complement(1395944..1396696) 1 NC_012967.1 Global transcription factor that controls the expression of over 100 target genes in response to anoxia; fumarate/nitrate reduction transcriptional regulator 1396696 fnr 8179019 fnr Escherichia coli B str. REL606 fumarate/nitrate reduction transcriptional regulator YP_003044521.1 1395944 R 413997 CDS YP_003044522.1 254161414 8176018 complement(1396891..1397406) 1 NC_012967.1 similar to b1335; O-6-alkylguanine-DNA:cysteine-protein methyltransferase 1397406 ogt 8176018 ogt Escherichia coli B str. REL606 O-6-alkylguanine-DNA:cysteine-protein methyltransferase YP_003044522.1 1396891 R 413997 CDS YP_003044523.1 254161415 8176019 complement(1397417..1398943) 1 NC_012967.1 similar to b1336; putative aminobenzoyl-glutamate transporter 1398943 abgT 8176019 abgT Escherichia coli B str. REL606 putative aminobenzoyl-glutamate transporter YP_003044523.1 1397417 R 413997 CDS YP_003044524.1 254161416 8178468 complement(1398980..1400425) 1 NC_012967.1 similar to b1337; putative peptidase, aminobenzoyl-glutamate utilization protein 1400425 abgB 8178468 abgB Escherichia coli B str. REL606 putative peptidase, aminobenzoyl-glutamate utilization protein YP_003044524.1 1398980 R 413997 CDS YP_003044525.1 254161417 8176020 complement(1400425..1401735) 1 NC_012967.1 similar to b1338; putative peptidase, aminobenzoyl-glutamate utilization protein 1401735 abgA 8176020 abgA Escherichia coli B str. REL606 putative peptidase, aminobenzoyl-glutamate utilization protein YP_003044525.1 1400425 R 413997 CDS YP_003044526.1 254161418 8176021 1401911..1402819 1 NC_012967.1 similar to b1339; putative DNA-binding transcriptional regulator 1402819 abgR 8176021 abgR Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003044526.1 1401911 D 413997 CDS YP_003044527.1 254161419 8176022 1403149..1403712 1 NC_012967.1 similar to b1340; hypothetical protein 1403712 ydaL 8176022 ydaL Escherichia coli B str. REL606 hypothetical protein YP_003044527.1 1403149 D 413997 CDS YP_003044528.1 254161420 8176023 complement(1403733..1404965) 1 NC_012967.1 similar to b1341; putative diguanylate cyclase, GGDEF domain signalling protein 1404965 ydaM 8176023 ydaM Escherichia coli B str. REL606 putative diguanylate cyclase, GGDEF domain signalling protein YP_003044528.1 1403733 R 413997 CDS YP_003044529.1 254161421 8176024 1405220..1406203 1 NC_012967.1 similar to b1342; zinc transporter 1406203 zntB 8176024 zntB Escherichia coli B str. REL606 zinc transporter YP_003044529.1 1405220 D 413997 CDS YP_003044530.1 254161422 8176025 1406681..1408054 1 NC_012967.1 exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA; ATP-dependent RNA helicase DbpA 1408054 dbpA 8176025 dbpA Escherichia coli B str. REL606 ATP-dependent RNA helicase DbpA YP_003044530.1 1406681 D 413997 CDS YP_003044531.1 254161423 8176026 complement(1408183..1409118) 1 NC_012967.1 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs; C32 tRNA thiolase 1409118 ydaO 8176026 ydaO Escherichia coli B str. REL606 C32 tRNA thiolase YP_003044531.1 1408183 R 413997 CDS YP_003044532.1 254161424 8179020 complement(1409170..1410405) 1 NC_012967.1 similar to b1345; integrase 1410405 intR 8179020 intR Escherichia coli B str. REL606 integrase YP_003044532.1 1409170 R 413997 CDS YP_003044533.1 254161425 8176027 complement(1410407..1410622) 1 NC_012967.1 similar to b1346; hypothetical protein 1410622 xisR 8176027 xisR Escherichia coli B str. REL606 hypothetical protein YP_003044533.1 1410407 R 413997 CDS YP_003044534.1 254161426 8179021 complement(1410701..1410910) 1 NC_012967.1 Rac prophage; hypothetical protein 1410910 ydaC 8179021 ydaC Escherichia coli B str. REL606 hypothetical protein YP_003044534.1 1410701 R 413997 CDS YP_003044535.1 254161427 8176028 complement(1410903..1411097) 1 NC_012967.1 seems to be involved in restriction alleviation and enhancement of modification by EcoKI, but not in restriction alleviation of type III restriction systems; Rac prophage; restriction alleviation and modification protein 1411097 lar 8176028 lar Escherichia coli B str. REL606 restriction alleviation and modification protein YP_003044535.1 1410903 R 413997 CDS YP_003044536.1 254161428 8176029 complement(1411154..1411963) 1 NC_012967.1 similar to b1349; recombination and repair protein RecT 1411963 recT 8176029 recT Escherichia coli B str. REL606 recombination and repair protein RecT YP_003044536.1 1411154 R 413997 CDS YP_003044537.1 254161429 8176030 complement(1411956..1414556) 1 NC_012967.1 The RecE (also known as exonuclease VIII) pathway is an alternative pathway for the initiation of homologous recombination in Escherichia coli. The RecE pathway is activated in recB, recC sbcA (suppressors of recB and recC) mutants. Activation of the RecE pathway results in the production of at least two phage proteins relevant for recombinational repair. RecE is a duplex DNA-specific exonuclease which produces 3' overhangs in duplex DNA by preferentially degrading the 5'-ending strands. Recombinational repair of E.coli chromosomal DNA involves as well other proteins: RecA, RecF, RecJ, RecO, RecR, and RuvC.; exonuclease VIII 1414556 recE 8176030 recE Escherichia coli B str. REL606 exonuclease VIII YP_003044537.1 1411956 R 413997 CDS YP_003044538.1 254161430 8176031 complement(1414658..1414933) 1 NC_012967.1 Rac prophage hypothetical protein; hypothetical protein 1414933 racC 8176031 racC Escherichia coli B str. REL606 hypothetical protein YP_003044538.1 1414658 R 413997 CDS YP_003044539.1 254161431 8178469 complement(1415008..1415178) 1 NC_012967.1 similar to b4526; hypothetical protein 1415178 ydaE 8178469 ydaE Escherichia coli B str. REL606 hypothetical protein YP_003044539.1 1415008 R 413997 CDS YP_003044540.1 254161432 8176032 complement(1415178..1415399) 1 NC_012967.1 Rac prophage Kil protein; Kil overexpression leads to morphological defects and inhibits cell division; FtsZ inhibitor protein 1415399 kil 8176032 kil Escherichia coli B str. REL606 FtsZ inhibitor protein YP_003044540.1 1415178 R 413997 CDS YP_003044541.1 254161433 8179022 1415841..1416329 1 NC_012967.1 similar to b1353; phage superinfection exclusion protein 1416329 sieB 8179022 sieB Escherichia coli B str. REL606 phage superinfection exclusion protein YP_003044541.1 1415841 D 413997 CDS YP_003044542.1 254161434 8176033 complement(1416326..1416481) 1 NC_012967.1 similar to b4527; hypothetical protein 1416481 ydaF 8176033 ydaF Escherichia coli B str. REL606 hypothetical protein YP_003044542.1 1416326 R 413997 CDS YP_003044543.1 254161435 8176034 complement(1416492..1416626) 1 NC_012967.1 similar to b1355; hypothetical protein 1416626 ydaG 8176034 ydaG Escherichia coli B str. REL606 hypothetical protein YP_003044543.1 1416492 R 413997 CDS YP_003044544.1 254161436 8178470 1416700..1416837 1 NC_012967.1 putative Lysozyme 1416837 8178470 ECB_01334 Escherichia coli B str. REL606 putative Lysozyme YP_003044544.1 1416700 D 413997 CDS YP_003044545.1 254161437 8176035 1416842..1417186 1 NC_012967.1 hypothetical protein 1417186 8176035 ECB_01335 Escherichia coli B str. REL606 hypothetical protein YP_003044545.1 1416842 D 413997 CDS YP_003044546.1 254161438 8176036 complement(1417152..1417424) 1 NC_012967.1 hypothetical protein 1417424 8176036 ECB_01336 Escherichia coli B str. REL606 hypothetical protein YP_003044546.1 1417152 R 413997 CDS YP_003044547.1 254161439 8176037 1417530..1418063 1 NC_012967.1 similar to b1554; putative lysozyme 1418063 ydfQ-1 8176037 ydfQ-1 Escherichia coli B str. REL606 putative lysozyme YP_003044547.1 1417530 D 413997 CDS YP_003044548.1 254161440 8176038 1418225..1418524 1 NC_012967.1 similar to b1362; putative defective peptidase 1418524 rzpR 8176038 rzpR Escherichia coli B str. REL606 putative defective peptidase YP_003044548.1 1418225 D 413997 CDS YP_003044549.1 254161441 8176039 1418662..1420119 1 NC_012967.1 similar to b1363; potassium transporter subunit 1420119 trkG 8176039 trkG Escherichia coli B str. REL606 potassium transporter subunit YP_003044549.1 1418662 D 413997 CDS YP_003044550.1 254161442 8178471 1420257..1420688 1 NC_012967.1 similar to b1365; hypothetical protein 1420688 ynaK 8178471 ynaK Escherichia coli B str. REL606 hypothetical protein YP_003044550.1 1420257 D 413997 CDS YP_003044551.1 254161443 8176040 1420721..1421557 1 NC_012967.1 hypothetical protein 1421557 8176040 ECB_01341 Escherichia coli B str. REL606 hypothetical protein YP_003044551.1 1420721 D 413997 CDS YP_003044552.1 254161444 8176041 1421656..1423881 1 NC_012967.1 hypothetical protein 1423881 8176041 ECB_01342 Escherichia coli B str. REL606 hypothetical protein YP_003044552.1 1421656 D 413997 CDS YP_003044553.1 254161445 8179023 1423878..1424156 1 NC_012967.1 hypothetical protein 1424156 8179023 ECB_01343 Escherichia coli B str. REL606 hypothetical protein YP_003044553.1 1423878 D 413997 CDS YP_003044554.1 254161446 8176042 1424169..1424462 1 NC_012967.1 hypothetical protein 1424462 8176042 ECB_01344 Escherichia coli B str. REL606 hypothetical protein YP_003044554.1 1424169 D 413997 CDS YP_003044555.1 254161447 8176043 complement(1424690..1425280) 1 NC_012967.1 similar to b1374; putative site-specific recombinase 1425280 pinR 8176043 pinR Escherichia coli B str. REL606 putative site-specific recombinase YP_003044555.1 1424690 R 413997 CDS YP_003044556.1 254161448 8179024 complement(1425597..1425863) 1 NC_012967.1 similar to b1375; putative DNA-binding transcriptional regulator 1425863 ynaE 8179024 ynaE Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003044556.1 1425597 R 413997 CDS YP_003044557.1 254161449 8176044 complement(1426791..1427225) 1 NC_012967.1 similar to b1376; stress-induced protein, ATP-binding protein 1427225 ynaF 8176044 ynaF Escherichia coli B str. REL606 stress-induced protein, ATP-binding protein YP_003044557.1 1426791 R 413997 CDS YP_003044558.1 254161450 8179025 complement(1427366..1428499) 1 NC_012967.1 similar to b1377; outer membrane pore protein N, non-specific 1428499 ompN 8179025 ompN Escherichia coli B str. REL606 outer membrane pore protein N, non-specific YP_003044558.1 1427366 R 413997 CDS YP_003044559.1 254161451 8176045 complement(1428866..1432390) 1 NC_012967.1 similar to b1378; fused pyruvate-flavodoxin oxidoreductase/hypothetical protein 1432390 ydbK 8176045 ydbK Escherichia coli B str. REL606 fused pyruvate-flavodoxin oxidoreductase/hypothetical protein YP_003044559.1 1428866 R 413997 CDS YP_003044560.1 254161452 8176046 1432664..1432930 1 NC_012967.1 similar to b4529; hypothetical protein 1432930 ydbJ 8176046 ydbJ Escherichia coli B str. REL606 hypothetical protein YP_003044560.1 1432664 D 413997 CDS YP_003044561.1 254161453 8176047 complement(1432927..1433349) 1 NC_012967.1 similar to b1379; heat-inducible protein 1433349 hslJ 8176047 hslJ Escherichia coli B str. REL606 heat-inducible protein YP_003044561.1 1432927 R 413997 CDS YP_003044562.1 254161454 8178472 complement(1433460..1434449) 1 NC_012967.1 similar to b1380; D-lactate dehydrogenase 1434449 ldhA 8178472 ldhA Escherichia coli B str. REL606 D-lactate dehydrogenase YP_003044562.1 1433460 R 413997 CDS YP_003044563.1 254161455 8176048 1434657..1437296 1 NC_012967.1 similar to b1381; hypothetical protein 1437296 ydbH 8176048 ydbH Escherichia coli B str. REL606 hypothetical protein YP_003044563.1 1434657 D 413997 CDS YP_003044564.1 254161456 8176049 1437293..1437478 1 NC_012967.1 similar to b1382; putative lipoprotein 1437478 ynbE 8176049 ynbE Escherichia coli B str. REL606 putative lipoprotein YP_003044564.1 1437293 D 413997 CDS YP_003044565.1 254161457 8176050 1437486..1437812 1 NC_012967.1 similar to b1383; hypothetical protein 1437812 ydbL 8176050 ydbL Escherichia coli B str. REL606 hypothetical protein YP_003044565.1 1437486 D 413997 CDS YP_003044566.1 254161458 8176051 complement(1437984..1438889) 1 NC_012967.1 activator of genes involved in phenylacetic acid catabolism; DNA-binding transcriptional activator FeaR 1438889 feaR 8176051 feaR Escherichia coli B str. REL606 DNA-binding transcriptional activator FeaR YP_003044566.1 1437984 R 413997 CDS YP_003044567.1 254161459 8178473 1439125..1440624 1 NC_012967.1 similar to b1385; phenylacetaldehyde dehydrogenase 1440624 feaB 8178473 feaB Escherichia coli B str. REL606 phenylacetaldehyde dehydrogenase YP_003044567.1 1439125 D 413997 CDS YP_003044568.1 254161460 8176052 complement(1440683..1442401) 1 NC_012967.1 similar to b1386; tyramine oxidase, copper-requiring 1442401 tynA 8176052 tynA Escherichia coli B str. REL606 tyramine oxidase, copper-requiring YP_003044568.1 1440683 R 413997 CDS YP_003044569.1 254161461 8176053 1442692..1443000 1 NC_012967.1 putative transposase-related protein 1443000 insE-2 8176053 insE-2 Escherichia coli B str. REL606 putative transposase-related protein YP_003044569.1 1442692 D 413997 CDS YP_003044570.1 254161462 8176054 1442997..1443863 1 NC_012967.1 IS3 element protein InsF 1443863 insF-2 8176054 insF-2 Escherichia coli B str. REL606 IS3 element protein InsF YP_003044570.1 1442997 D 413997 CDS YP_003044571.1 254161463 8179026 1443881..1444414 1 NC_012967.1 similar to b1406; putative oxidoreductase 1444414 ydbC 8179026 ydbC Escherichia coli B str. REL606 putative oxidoreductase YP_003044571.1 1443881 D 413997 CDS YP_003044572.1 254161464 8176055 1444478..1446784 1 NC_012967.1 similar to b1407; hypothetical protein 1446784 ydbD 8176055 ydbD Escherichia coli B str. REL606 hypothetical protein YP_003044572.1 1444478 D 413997 CDS YP_003044573.1 254161465 8176056 1446955..1447560 1 NC_012967.1 similar to b1408; putative inner membrane protein 1447560 ynbA 8176056 ynbA Escherichia coli B str. REL606 putative inner membrane protein YP_003044573.1 1446955 D 413997 CDS YP_003044574.1 254161466 8176057 1447560..1448456 1 NC_012967.1 similar to b1409; putative CDP-diglyceride synthase 1448456 ynbB 8176057 ynbB Escherichia coli B str. REL606 putative CDP-diglyceride synthase YP_003044574.1 1447560 D 413997 CDS YP_003044575.1 254161467 8176058 1448472..1450229 1 NC_012967.1 similar to b1410; putative hydrolase 1450229 ynbC 8176058 ynbC Escherichia coli B str. REL606 putative hydrolase YP_003044575.1 1448472 D 413997 CDS YP_003044576.1 254161468 8176059 1450243..1451535 1 NC_012967.1 similar to b1411; putative phosphatase, inner membrane protein 1451535 ynbD 8176059 ynbD Escherichia coli B str. REL606 putative phosphatase, inner membrane protein YP_003044576.1 1450243 D 413997 CDS YP_003044577.1 254161469 8179027 complement(1451586..1452191) 1 NC_012967.1 FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds; azoreductase 1452191 acpD 8179027 acpD Escherichia coli B str. REL606 azoreductase YP_003044577.1 1451586 R 413997 CDS YP_003044578.1 254161470 8176060 1452449..1456294 1 NC_012967.1 involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain; ATP-dependent RNA helicase HrpA 1456294 hrpA 8176060 hrpA Escherichia coli B str. REL606 ATP-dependent RNA helicase HrpA YP_003044578.1 1452449 D 413997 CDS YP_003044579.1 254161471 8176061 1456566..1457366 1 NC_012967.1 similar to b1414; hypothetical protein 1457366 ydcF 8176061 ydcF Escherichia coli B str. REL606 hypothetical protein YP_003044579.1 1456566 D 413997 CDS YP_003044580.1 254161472 8178474 1457563..1459002 1 NC_012967.1 NAD-linked; aldehyde dehydrogenase A 1459002 aldA 8178474 aldA Escherichia coli B str. REL606 aldehyde dehydrogenase A YP_003044580.1 1457563 D 413997 CDS YP_003044581.1 254161473 8176062 complement(1459044..1460045) 1 NC_012967.1 similar to b1416-b1417(b4493); pseudo in K-12 MG1655; glyceraldehyde-3-phosphate dehydrogenase 1460045 gapC 8176062 gapC Escherichia coli B str. REL606 glyceraldehyde-3-phosphate dehydrogenase YP_003044581.1 1459044 R 413997 CDS YP_003044582.1 254161474 8179028 1460215..1460490 1 NC_012967.1 IS1 protein InsA 1460490 insA-12 8179028 insA-12 Escherichia coli B str. REL606 IS1 protein InsA YP_003044582.1 1460215 D 413997 CDS YP_003044583.1 254161475 8176063 1460409..1460912 1 NC_012967.1 IS1 protein InsB 1460912 insB-12 8176063 insB-12 Escherichia coli B str. REL606 IS1 protein InsB YP_003044583.1 1460409 D 413997 CDS YP_003044584.1 254161476 8176064 1461011..1461541 1 NC_012967.1 B-type di-heme cytochrome with a major alpha-absorption peak at 561 nm and a minor peak at 555 nm; cytochrome b561 1461541 cybB 8176064 cybB Escherichia coli B str. REL606 cytochrome b561 YP_003044584.1 1461011 D 413997 CDS YP_003044585.1 254161477 8176065 1461786..1461959 1 NC_012967.1 similar to b1419; hypothetical protein 1461959 ydcA 8176065 ydcA Escherichia coli B str. REL606 hypothetical protein YP_003044585.1 1461786 D 413997 CDS YP_003044586.1 254161478 8178475 complement(1462031..1462180) 1 NC_012967.1 similar to b4428; small toxic polypeptide 1462180 hokB 8178475 hokB Escherichia coli B str. REL606 small toxic polypeptide YP_003044586.1 1462031 R 413997 CDS YP_003044587.1 254161479 8176066 complement(1462071..1462238) 1 NC_012967.1 similar to b1420; regulatory peptide 1462238 mokB 8176066 mokB Escherichia coli B str. REL606 regulatory peptide YP_003044587.1 1462071 R 413997 CDS YP_003044588.1 254161480 8176067 1462579..1464219 1 NC_012967.1 similar to b1421; methyl-accepting chemotaxis protein III, ribose and galactose sensor receptor 1464219 trg 8176067 trg Escherichia coli B str. REL606 methyl-accepting chemotaxis protein III, ribose and galactose sensor receptor YP_003044588.1 1462579 D 413997 CDS YP_003044589.1 254161481 8176068 complement(1464257..1465180) 1 NC_012967.1 similar to b1422; putative DNA-binding transcriptional regulator 1465180 ydcI 8176068 ydcI Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003044589.1 1464257 R 413997 CDS YP_003044590.1 254161482 8176069 1465397..1466740 1 NC_012967.1 similar to b1423; hypothetical protein 1466740 ydcJ 8176069 ydcJ Escherichia coli B str. REL606 hypothetical protein YP_003044590.1 1465397 D 413997 CDS YP_003044591.1 254161483 8178476 1466995..1468620 1 NC_012967.1 involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans; glucan biosynthesis protein D 1468620 mdoD 8178476 mdoD Escherichia coli B str. REL606 glucan biosynthesis protein D YP_003044591.1 1466995 D 413997 CDS YP_003044592.1 254161484 8176070 complement(1468541..1468744) 1 NC_012967.1 similar to b1425; deleted from K-12 MG1655; hypothetical protein 1468744 8176070 ECB_01382 Escherichia coli B str. REL606 hypothetical protein YP_003044592.1 1468541 R 413997 CDS YP_003044593.1 254161485 8176071 1468760..1468984 1 NC_012967.1 similar to b1426; hypothetical protein 1468984 ydcH 8176071 ydcH Escherichia coli B str. REL606 hypothetical protein YP_003044593.1 1468760 D 413997 CDS YP_003044594.1 254161486 8179029 1469047..1469586 1 NC_012967.1 similar to b1427; ribosomal-protein-L7/L12-serine acetyltransferase 1469586 rimL 8179029 rimL Escherichia coli B str. REL606 ribosomal-protein-L7/L12-serine acetyltransferase YP_003044594.1 1469047 D 413997 CDS YP_003044595.1 254161487 8176072 complement(1469578..1470558) 1 NC_012967.1 similar to b1428; hypothetical protein 1470558 ydcK 8176072 ydcK Escherichia coli B str. REL606 hypothetical protein YP_003044595.1 1469578 R 413997 CDS YP_003044596.1 254161488 8176073 1470682..1471674 1 NC_012967.1 similar to b1429; potassium-tellurite ethidium and proflavin transporter 1471674 tehA 8176073 tehA Escherichia coli B str. REL606 potassium-tellurite ethidium and proflavin transporter YP_003044596.1 1470682 D 413997 CDS YP_003044597.1 254161489 8176074 1471671..1472264 1 NC_012967.1 with TehA confers resistance to tellurite; tellurite resistance protein TehB 1472264 tehB 8176074 tehB Escherichia coli B str. REL606 tellurite resistance protein TehB YP_003044597.1 1471671 D 413997 CDS YP_003044598.1 254161490 8176075 1472567..1473235 1 NC_012967.1 similar to b1431; putative lipoprotein 1473235 ydcL 8176075 ydcL Escherichia coli B str. REL606 putative lipoprotein YP_003044598.1 1472567 D 413997 CDS YP_003044599.1 254161491 8176077 1473767..1474975 1 NC_012967.1 similar to b1432; putative transposase 1474975 ydcM 8176077 ydcM Escherichia coli B str. REL606 putative transposase YP_003044599.1 1473767 D 413997 CDS YP_003044600.1 254161492 8176078 complement(1475015..1476190) 1 NC_012967.1 similar to b1433; putative benzoate transporter 1476190 ydcO 8176078 ydcO Escherichia coli B str. REL606 putative benzoate transporter YP_003044600.1 1475015 R 413997 CDS YP_003044601.1 254161493 8176079 1476282..1476818 1 NC_012967.1 similar to b1434; putative DNA-binding transcriptional regulator 1476818 ydcN 8176079 ydcN Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003044601.1 1476282 D 413997 CDS YP_003044602.1 254161494 8176080 1476891..1478852 1 NC_012967.1 similar to b1435; putative peptidase 1478852 ydcP 8176080 ydcP Escherichia coli B str. REL606 putative peptidase YP_003044602.1 1476891 D 413997 CDS YP_003044603.1 254161495 8179030 complement(1478944..1479174) 1 NC_012967.1 similar to b1436; hypothetical protein 1479174 yncJ 8179030 yncJ Escherichia coli B str. REL606 hypothetical protein YP_003044603.1 1478944 R 413997 CDS YP_003044604.1 254161496 8176081 1479597..1480034 1 NC_012967.1 similar to b1438; putative DNA-binding transcriptional regulator 1480034 ydcQ 8176081 ydcQ Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003044604.1 1479597 D 413997 CDS YP_003044605.1 254161497 8176082 1480113..1481519 1 NC_012967.1 similar to b1439; bifunctional DNA-binding transcriptional regulator/amino transferase 1481519 ydcR 8176082 ydcR Escherichia coli B str. REL606 bifunctional DNA-binding transcriptional regulator/amino transferase YP_003044605.1 1480113 D 413997 CDS YP_003044606.1 254161498 8176083 1481764..1482909 1 NC_012967.1 similar to b1440; putative spermidine/putrescine transporter subunit 1482909 ydcS 8176083 ydcS Escherichia coli B str. REL606 putative spermidine/putrescine transporter subunit YP_003044606.1 1481764 D 413997 CDS YP_003044607.1 254161499 8176084 1482927..1483940 1 NC_012967.1 similar to b1441; putative spermidine/putrescine transporter subunit 1483940 ydcT 8176084 ydcT Escherichia coli B str. REL606 putative spermidine/putrescine transporter subunit YP_003044607.1 1482927 D 413997 CDS YP_003044608.1 254161500 8176085 1483941..1484882 1 NC_012967.1 similar to b1442; putative spermidine/putrescine transporter subunit 1484882 ydcU 8176085 ydcU Escherichia coli B str. REL606 putative spermidine/putrescine transporter subunit YP_003044608.1 1483941 D 413997 CDS YP_003044609.1 254161501 8178477 1484872..1485666 1 NC_012967.1 similar to b1443; putative spermidine/putrescine transporter subunit 1485666 ydcV 8178477 ydcV Escherichia coli B str. REL606 putative spermidine/putrescine transporter subunit YP_003044609.1 1484872 D 413997 CDS YP_003044610.1 254161502 8176086 1485688..1487112 1 NC_012967.1 catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation; gamma-aminobutyraldehyde dehydrogenase 1487112 ydcW 8176086 ydcW Escherichia coli B str. REL606 gamma-aminobutyraldehyde dehydrogenase YP_003044610.1 1485688 D 413997 CDS YP_003044611.1 254161503 8176087 1487499..1487672 1 NC_012967.1 similar to b1445; putative inner membrane protein 1487672 ydcX 8176087 ydcX Escherichia coli B str. REL606 putative inner membrane protein YP_003044611.1 1487499 D 413997 CDS YP_003044612.1 254161504 8176088 1487758..1487991 1 NC_012967.1 similar to b1446; hypothetical protein 1487991 ydcY 8176088 ydcY Escherichia coli B str. REL606 hypothetical protein YP_003044612.1 1487758 D 413997 CDS YP_003044613.1 254161505 8176089 complement(1487992..1488441) 1 NC_012967.1 similar to b1447; putative inner membrane protein 1488441 ydcZ 8176089 ydcZ Escherichia coli B str. REL606 putative inner membrane protein YP_003044613.1 1487992 R 413997 CDS YP_003044614.1 254161506 8176090 complement(1488438..1488956) 1 NC_012967.1 similar to b1448; putative acyltransferase with acyl-CoA N-acyltransferase domain 1488956 yncA 8176090 yncA Escherichia coli B str. REL606 putative acyltransferase with acyl-CoA N-acyltransferase domain YP_003044614.1 1488438 R 413997 CDS YP_003044615.1 254161507 8176091 1489137..1490174 1 NC_012967.1 similar to b1449; putative oxidoreductase, Zn-dependent and NAD(P)-binding 1490174 yncB 8176091 yncB Escherichia coli B str. REL606 putative oxidoreductase, Zn-dependent and NAD(P)-binding YP_003044615.1 1489137 D 413997 CDS YP_003044616.1 254161508 8176092 1490372..1491037 1 NC_012967.1 similar to b1450; putative DNA-binding transcriptional regulator 1491037 yncC 8176092 yncC Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003044616.1 1490372 D 413997 CDS YP_003044617.1 254161509 8176093 complement(1491073..1493175) 1 NC_012967.1 similar to b1451; putative iron outer membrane transporter 1493175 yncD 8176093 yncD Escherichia coli B str. REL606 putative iron outer membrane transporter YP_003044617.1 1491073 R 413997 CDS YP_003044618.1 254161510 8176094 1493417..1494478 1 NC_012967.1 similar to b1452; hypothetical protein 1494478 yncE 8176094 yncE Escherichia coli B str. REL606 hypothetical protein YP_003044618.1 1493417 D 413997 CDS YP_003044619.1 254161511 8176095 complement(1494593..1496092) 1 NC_012967.1 similar to b1453; L-asparagine transporter 1496092 ansP 8176095 ansP Escherichia coli B str. REL606 L-asparagine transporter YP_003044619.1 1494593 R 413997 CDS YP_003044620.1 254161512 8178478 1496359..1496976 1 NC_012967.1 similar to b1454; hypothetical protein 1496976 yncG 8178478 yncG Escherichia coli B str. REL606 hypothetical protein YP_003044620.1 1496359 D 413997 CDS YP_003044621.1 254161513 8176096 1497052..1497264 1 NC_012967.1 similar to b1455; hypothetical protein 1497264 yncH 8176096 yncH Escherichia coli B str. REL606 hypothetical protein YP_003044621.1 1497052 D 413997 CDS YP_003044622.1 254161514 8176097 1498084..1500210 1 NC_012967.1 hypothetical protein 1500210 8176097 ECB_01413 Escherichia coli B str. REL606 hypothetical protein YP_003044622.1 1498084 D 413997 CDS YP_003044623.1 254161515 8178479 1500277..1504500 1 NC_012967.1 similar to b1456; rhsE element core protein RshE 1504500 rhsE 8178479 rhsE Escherichia coli B str. REL606 rhsE element core protein RshE YP_003044623.1 1500277 D 413997 CDS YP_003044624.1 254161516 8176098 1504484..1504966 1 NC_012967.1 similar to b1457; hypothetical protein 1504966 ydcD 8176098 ydcD Escherichia coli B str. REL606 hypothetical protein YP_003044624.1 1504484 D 413997 CDS YP_003044625.1 254161517 8176099 1505148..1505894 1 NC_012967.1 similar to b1458; hypothetical protein 1505894 8176099 ECB_01416 Escherichia coli B str. REL606 hypothetical protein YP_003044625.1 1505148 D 413997 CDS YP_003044626.1 254161518 8179031 1505938..1506138 1 NC_012967.1 similar to b1459; hypothetical protein 1506138 8179031 ECB_01417 Escherichia coli B str. REL606 hypothetical protein YP_003044626.1 1505938 D 413997 CDS YP_003044627.1 254161519 8176100 1506378..1507169 1 NC_012967.1 similar to b1460; hypothetical protein 1507169 ydcC 8176100 ydcC Escherichia coli B str. REL606 hypothetical protein YP_003044627.1 1506378 D 413997 CDS YP_003044628.1 254161520 8176101 1507202..1507429 1 NC_012967.1 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown; 4-oxalocrotonate tautomerase 1507429 ydcE 8176101 ydcE Escherichia coli B str. REL606 4-oxalocrotonate tautomerase YP_003044628.1 1507202 D 413997 CDS YP_003044629.1 254161521 8179032 complement(1507433..1508002) 1 NC_012967.1 similar to b1462; hypothetical protein 1508002 yddH 8179032 yddH Escherichia coli B str. REL606 hypothetical protein YP_003044629.1 1507433 R 413997 CDS YP_003044630.1 254161522 8176102 1508175..1509020 1 NC_012967.1 similar to b1463; N-hydroxyarylamine O-acetyltransferase 1509020 nhoA 8176102 nhoA Escherichia coli B str. REL606 N-hydroxyarylamine O-acetyltransferase YP_003044630.1 1508175 D 413997 CDS YP_003044631.1 254161523 8179033 complement(1510088..1510768) 1 NC_012967.1 similar to b1465; nitrate reductase 2 subunit gamma 1510768 narV 8179033 narV Escherichia coli B str. REL606 nitrate reductase 2 subunit gamma YP_003044631.1 1510088 R 413997 CDS YP_003044632.1 254161524 8176104 complement(1510765..1511460) 1 NC_012967.1 similar to b1466; nitrate reductase 2 subunit delta (assembly subunit) 1511460 narW 8176104 narW Escherichia coli B str. REL606 nitrate reductase 2 subunit delta (assembly subunit) YP_003044632.1 1510765 R 413997 CDS YP_003044633.1 254161525 8176105 complement(1511460..1513004) 1 NC_012967.1 similar to b1467; nitrate reductase 2 subunit beta 1513004 narY 8176105 narY Escherichia coli B str. REL606 nitrate reductase 2 subunit beta YP_003044633.1 1511460 R 413997 CDS YP_003044634.1 254161526 8176106 complement(1513001..1516741) 1 NC_012967.1 similar to b1468; nitrate reductase 2 subunit alpha 1516741 narZ 8176106 narZ Escherichia coli B str. REL606 nitrate reductase 2 subunit alpha YP_003044634.1 1513001 R 413997 CDS YP_003044635.1 254161527 8176107 complement(1516823..1518211) 1 NC_012967.1 similar to b1469; nitrate/nitrite transporter 1518211 narU 8176107 narU Escherichia coli B str. REL606 nitrate/nitrite transporter YP_003044635.1 1516823 R 413997 CDS YP_003044636.1 254161528 8176108 complement(1518535..1518870) 1 NC_012967.1 similar to b1470; hypothetical protein 1518870 yddJ 8176108 yddJ Escherichia coli B str. REL606 hypothetical protein YP_003044636.1 1518535 R 413997 CDS YP_003044637.1 254161529 8176109 complement(1518909..1519865) 1 NC_012967.1 similar to b1471; hypothetical protein 1519865 yddK 8176109 yddK Escherichia coli B str. REL606 hypothetical protein YP_003044637.1 1518909 R 413997 CDS YP_003044638.1 254161530 8176110 complement(1519889..1520179) 1 NC_012967.1 similar to b1472; putative lipoprotein 1520179 yddL 8176110 yddL Escherichia coli B str. REL606 putative lipoprotein YP_003044638.1 1519889 R 413997 CDS YP_003044639.1 254161531 8178480 complement(1520438..1521262) 1 NC_012967.1 similar to b1473; hypothetical protein 1521262 yddG 8178480 yddG Escherichia coli B str. REL606 hypothetical protein YP_003044639.1 1520438 R 413997 CDS YP_003044640.1 254161532 8176111 1521551..1524598 1 NC_012967.1 similar to b1474; selenocysteine; formate dehydrogenase-N, subunit alpha, nitrate-inducible 1524598 fdnG 8176111 fdnG Escherichia coli B str. REL606 formate dehydrogenase-N, subunit alpha, nitrate-inducible YP_003044640.1 1521551 D 413997 CDS YP_003044641.1 254161533 8176112 1524611..1525495 1 NC_012967.1 similar to b1475; formate dehydrogenase-N, Fe-S subunit beta, nitrate-inducible 1525495 fdnH 8176112 fdnH Escherichia coli B str. REL606 formate dehydrogenase-N, Fe-S subunit beta, nitrate-inducible YP_003044641.1 1524611 D 413997 CDS YP_003044642.1 254161534 8178481 1525488..1526141 1 NC_012967.1 nitrate-inducible, cytochrome b556(fdn) component of formate dehydrogenase; formate dehydrogenase-N subunit gamma 1526141 fdnI 8178481 fdnI Escherichia coli B str. REL606 formate dehydrogenase-N subunit gamma YP_003044642.1 1525488 D 413997 CDS YP_003044643.1 254161535 8176113 complement(1526336..1526698) 1 NC_012967.1 similar to b1477; putative DNA-binding transcriptional regulator 1526698 yddM 8176113 yddM Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003044643.1 1526336 R 413997 CDS YP_003044644.1 254161536 8176114 complement(1526766..1527776) 1 NC_012967.1 similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase 1527776 adhP 8176114 adhP Escherichia coli B str. REL606 alcohol dehydrogenase YP_003044644.1 1526766 R 413997 CDS YP_003044645.1 254161537 8178482 complement(1527910..1529607) 1 NC_012967.1 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase 1529607 sfcA 8178482 sfcA Escherichia coli B str. REL606 malate dehydrogenase YP_003044645.1 1527910 R 413997 CDS YP_003044646.1 254161538 8176115 complement(1529764..1529901) 1 NC_012967.1 protein D; stationary-phase-induced ribosome-associated; in Escherichia coli this protein becomes associated with the ribosome; expression increases during stationary phase; 30S ribosomal subunit S22 1529901 rpsV 8176115 rpsV Escherichia coli B str. REL606 30S ribosomal subunit S22 YP_003044646.1 1529764 R 413997 CDS YP_003044647.1 254161539 8176116 complement(1530003..1530218) 1 NC_012967.1 similar to b1481; biofilm-dependent modulation protein 1530218 bdm 8176116 bdm Escherichia coli B str. REL606 biofilm-dependent modulation protein YP_003044647.1 1530003 R 413997 CDS YP_003044648.1 254161540 8179034 1530563..1530994 1 NC_012967.1 similar to b1482; osmotically inducible, stress-inducible membrane protein 1530994 osmC 8179034 osmC Escherichia coli B str. REL606 osmotically inducible, stress-inducible membrane protein YP_003044648.1 1530563 D 413997 CDS YP_003044649.1 254161541 8176117 complement(1531050..1531976) 1 NC_012967.1 similar to b1483; D-ala-D-ala transporter subunit 1531976 yddO 8176117 yddO Escherichia coli B str. REL606 D-ala-D-ala transporter subunit YP_003044649.1 1531050 R 413997 CDS YP_003044650.1 254161542 8176118 complement(1531969..1532955) 1 NC_012967.1 similar to b1484; D-ala-D-ala transporter subunit 1532955 yddP 8176118 yddP Escherichia coli B str. REL606 D-ala-D-ala transporter subunit YP_003044650.1 1531969 R 413997 CDS YP_003044651.1 254161543 8179035 complement(1532952..1533848) 1 NC_012967.1 similar to b1485; ATP-dependent peptide transporter membrane subunit 1533848 yddQ 8179035 yddQ Escherichia coli B str. REL606 ATP-dependent peptide transporter membrane subunit YP_003044651.1 1532952 R 413997 CDS YP_003044652.1 254161544 8176119 complement(1533845..1534867) 1 NC_012967.1 similar to b1486; D-ala-D-ala transporter subunit 1534867 yddR 8176119 yddR Escherichia coli B str. REL606 D-ala-D-ala transporter subunit YP_003044652.1 1533845 R 413997 CDS YP_003044653.1 254161545 8176120 complement(1534869..1536419) 1 NC_012967.1 similar to b1487; D-ala-D-a la transporter subunit 1536419 yddS 8176120 yddS Escherichia coli B str. REL606 D-ala-D-a la transporter subunit YP_003044653.1 1534869 R 413997 CDS YP_003044654.1 254161546 8176121 complement(1536433..1537014) 1 NC_012967.1 catalyzes the hydrolysis of D-alanyl-D-alanine dipeptide: Zn dependent; involved in peptidoglycan synthesis; D-alanyl-D-alanine dipeptidase 1537014 ddpX 8176121 ddpX Escherichia coli B str. REL606 D-alanyl-D-alanine dipeptidase YP_003044654.1 1536433 R 413997 CDS YP_003044655.1 254161547 8176122 complement(1537272..1539671) 1 NC_012967.1 heme-regulated phosphodiesterase with phosphodiesterase activity with cAMP but not with cGMP, bis(p-nitrophenyl) phosphate or p-nitrophenyl phosphate; cAMP phosphodiesterase 1539671 dos 8176122 dos Escherichia coli B str. REL606 cAMP phosphodiesterase YP_003044655.1 1537272 R 413997 CDS YP_003044656.1 254161548 8176123 complement(1539696..1540739) 1 NC_012967.1 similar to b1490; putative diguanylate cyclase 1540739 yddV 8176123 yddV Escherichia coli B str. REL606 putative diguanylate cyclase YP_003044656.1 1539696 R 413997 CDS YP_003044657.1 254161549 8176124 complement(1541455..1542774) 1 NC_012967.1 similar to b1491; putative liprotein 1542774 yddW 8176124 yddW Escherichia coli B str. REL606 putative liprotein YP_003044657.1 1541455 R 413997 CDS YP_003044658.1 254161550 8176125 complement(1542905..1544440) 1 NC_012967.1 similar to b1492; putative glutamate:gamma-aminobutyric acid antiporter 1544440 xasA 8176125 xasA Escherichia coli B str. REL606 putative glutamate:gamma-aminobutyric acid antiporter YP_003044658.1 1542905 R 413997 CDS YP_003044659.1 254161551 8178483 complement(1544596..1545996) 1 NC_012967.1 similar to b1493; glutamate decarboxylase B, PLP-dependent 1545996 gadB 8178483 gadB Escherichia coli B str. REL606 glutamate decarboxylase B, PLP-dependent YP_003044659.1 1544596 R 413997 CDS YP_003044660.1 254161552 8176126 complement(1546358..1549153) 1 NC_012967.1 similar to b1494; putative peptidase 1549153 pqqL 8176126 pqqL Escherichia coli B str. REL606 putative peptidase YP_003044660.1 1546358 R 413997 CDS YP_003044661.1 254161553 8176127 complement(1549198..1551570) 1 NC_012967.1 similar to b1495; putative porin protein 1551570 yddB 8176127 yddB Escherichia coli B str. REL606 putative porin protein YP_003044661.1 1549198 R 413997 CDS YP_003044662.1 254161554 8178484 complement(1551608..1553293) 1 NC_012967.1 similar to b1496; multidrug ABC transporter membrane/ATP-binding protein 1553293 yddA 8178484 yddA Escherichia coli B str. REL606 multidrug ABC transporter membrane/ATP-binding protein YP_003044662.1 1551608 R 413997 CDS YP_003044663.1 254161555 8176128 complement(1553584..1554741) 1 NC_012967.1 similar to b1497; hypothetical protein 1554741 ydeM 8176128 ydeM Escherichia coli B str. REL606 hypothetical protein YP_003044663.1 1553584 R 413997 CDS YP_003044664.1 254161556 8176129 complement(1554793..1556475) 1 NC_012967.1 similar to b1498; hypothetical protein 1556475 ydeN 8176129 ydeN Escherichia coli B str. REL606 hypothetical protein YP_003044664.1 1554793 R 413997 CDS YP_003044665.1 254161557 8178485 complement(1556877..1557638) 1 NC_012967.1 regulates the cellular response to acid resistance; transcriptional regulator YdeO 1557638 ydeO 8178485 ydeO Escherichia coli B str. REL606 transcriptional regulator YdeO YP_003044665.1 1556877 R 413997 CDS YP_003044666.1 254161558 8176130 complement(1557713..1557910) 1 NC_012967.1 similar to b1500; deleted from K-12 MG1655; hypothetical protein 1557910 8176130 ECB_01458 Escherichia coli B str. REL606 hypothetical protein YP_003044666.1 1557713 R 413997 CDS YP_003044667.1 254161559 8176131 complement(1558158..1560437) 1 NC_012967.1 in Escherichia coli it may be involved in repression of type III secretion system (TTSS) genes of the host cell; involved with increased resistance to low pH; member of the prokaryotic molybdopterin-containing oxidoreductase family; putative oxidoreductase 1560437 ydeP 8176131 ydeP Escherichia coli B str. REL606 putative oxidoreductase YP_003044667.1 1558158 R 413997 CDS YP_003044668.1 254161560 8179036 complement(1560771..1561685) 1 NC_012967.1 similar to b1502; putative fimbrial-like adhesin protein 1561685 ydeQ 8179036 ydeQ Escherichia coli B str. REL606 putative fimbrial-like adhesin protein YP_003044668.1 1560771 R 413997 CDS YP_003044669.1 254161561 8176132 complement(1561744..1562247) 1 NC_012967.1 similar to b1503; putative fimbrial-like adhesin protein 1562247 ydeR 8176132 ydeR Escherichia coli B str. REL606 putative fimbrial-like adhesin protein YP_003044669.1 1561744 R 413997 CDS YP_003044670.1 254161562 8176133 complement(1562260..1562790) 1 NC_012967.1 similar to b1504; putative fimbrial-like adhesin protein 1562790 ydeS 8176133 ydeS Escherichia coli B str. REL606 putative fimbrial-like adhesin protein YP_003044670.1 1562260 R 413997 CDS YP_003044671.1 254161563 8179037 complement(1562804..1563952) 1 NC_012967.1 similar to b1505; hypothetical protein 1563952 ydeT 8179037 ydeT Escherichia coli B str. REL606 hypothetical protein YP_003044671.1 1562804 R 413997 CDS YP_003044672.1 254161564 8179038 complement(1566567..1567103) 1 NC_012967.1 similar to b1506; putative transcriptional regulator 1567103 yneL 8179038 yneL Escherichia coli B str. REL606 putative transcriptional regulator YP_003044672.1 1566567 R 413997 CDS YP_003044673.1 254161565 8176136 complement(1567421..1568743) 1 NC_012967.1 similar to b1507; regulator with hipB 1568743 hipA 8176136 hipA Escherichia coli B str. REL606 regulator with hipB YP_003044673.1 1567421 R 413997 CDS YP_003044674.1 254161566 8176137 complement(1568743..1569009) 1 NC_012967.1 similar to b1508; DNA-binding transcriptional regulator HipB 1569009 hipB 8176137 hipB Escherichia coli B str. REL606 DNA-binding transcriptional regulator HipB YP_003044674.1 1568743 R 413997 CDS YP_003044675.1 254161567 8176139 1570787..1571584 1 NC_012967.1 similar to b1515; AI2 transporter 1571584 ydeZ 8176139 ydeZ Escherichia coli B str. REL606 AI2 transporter YP_003044675.1 1570787 D 413997 CDS YP_003044676.1 254161568 8176140 1571596..1572618 1 NC_012967.1 similar to b1516; AI2 transporter 1572618 yneA 8176140 yneA Escherichia coli B str. REL606 AI2 transporter YP_003044676.1 1571596 D 413997 CDS YP_003044677.1 254161569 8176141 1572645..1573520 1 NC_012967.1 similar to b1517; aldolase 1573520 yneB 8176141 yneB Escherichia coli B str. REL606 aldolase YP_003044677.1 1572645 D 413997 CDS YP_003044678.1 254161570 8176142 1573544..1573834 1 NC_012967.1 similar to b1518; autoinducer-2 (AI-2) modifying protein LsrG 1573834 yneC 8176142 yneC Escherichia coli B str. REL606 autoinducer-2 (AI-2) modifying protein LsrG YP_003044678.1 1573544 D 413997 CDS YP_003044679.1 254161571 8178486 1573891..1574649 1 NC_012967.1 catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate; trans-aconitate 2-methyltransferase 1574649 tam 8178486 tam Escherichia coli B str. REL606 trans-aconitate 2-methyltransferase YP_003044679.1 1573891 D 413997 CDS YP_003044680.1 254161572 8176143 complement(1574653..1575567) 1 NC_012967.1 similar to b1520; inner membrane protein 1575567 yneE 8176143 yneE Escherichia coli B str. REL606 inner membrane protein YP_003044680.1 1574653 R 413997 CDS YP_003044681.1 254161573 8176144 complement(1575774..1577225) 1 NC_012967.1 catalyzes the formation of D-tagaturonate from D-altronate; altronate oxidoreductase 1577225 uxaB 8176144 uxaB Escherichia coli B str. REL606 altronate oxidoreductase YP_003044681.1 1575774 R 413997 CDS YP_003044682.1 254161574 8178487 complement(1577452..1578399) 1 NC_012967.1 similar to b1522; putative diguanylate cyclase 1578399 yneF 8178487 yneF Escherichia coli B str. REL606 putative diguanylate cyclase YP_003044682.1 1577452 R 413997 CDS YP_003044683.1 254161575 8176145 complement(1579009..1579368) 1 NC_012967.1 similar to b1523; hypothetical protein 1579368 yneG 8176145 yneG Escherichia coli B str. REL606 hypothetical protein YP_003044683.1 1579009 R 413997 CDS YP_003044684.1 254161576 8176146 complement(1579368..1580294) 1 NC_012967.1 catalyzes the formation of glutamate from glutamine; glutaminase 1580294 yneH 8176146 yneH Escherichia coli B str. REL606 glutaminase YP_003044684.1 1579368 R 413997 CDS YP_003044685.1 254161577 8179039 complement(1580358..1581746) 1 NC_012967.1 in Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase; putative succinate semialdehyde dehydrogenase 1581746 yneI 8179039 yneI Escherichia coli B str. REL606 putative succinate semialdehyde dehydrogenase YP_003044685.1 1580358 R 413997 CDS YP_003044686.1 254161578 8176147 1581847..1582728 1 NC_012967.1 similar to b1526; putative DNA-binding transcriptional regulator 1582728 yneJ 8176147 yneJ Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003044686.1 1581847 D 413997 CDS YP_003044687.1 254161579 8176148 1582806..1583921 1 NC_012967.1 similar to b1527; hypothetical protein 1583921 yneK 8176148 yneK Escherichia coli B str. REL606 hypothetical protein YP_003044687.1 1582806 D 413997 CDS YP_003044688.1 254161580 8179040 1584071..1585261 1 NC_012967.1 similar to b1528; sugar efflux transporter 1585261 sotB 8179040 sotB Escherichia coli B str. REL606 sugar efflux transporter YP_003044688.1 1584071 D 413997 CDS YP_003044689.1 254161581 8176149 complement(1585286..1585951) 1 NC_012967.1 protein involved in resistance to different drugs (tetracycline, chloramphenicol, beta-lactams, and quinolones); part of the multiple antibiotic resistance (mar) locus, which is composed by the genes marC and marRAB; unknown function; multiple drug resistance protein MarC 1585951 marC 8176149 marC Escherichia coli B str. REL606 multiple drug resistance protein MarC YP_003044689.1 1585286 R 413997 CDS YP_003044690.1 254161582 8178488 complement(1586072..1586356) 1 NC_012967.1 phage N15 gp48-like protein 1586356 8178488 ECB_01487 Escherichia coli B str. REL606 phage N15 gp48-like protein YP_003044690.1 1586072 R 413997 CDS YP_003044691.1 254161583 8176150 complement(1586346..1586666) 1 NC_012967.1 hypothetical protein 1586666 8176150 ECB_01488 Escherichia coli B str. REL606 hypothetical protein YP_003044691.1 1586346 R 413997 CDS YP_003044692.1 254161584 8176151 1586886..1587320 1 NC_012967.1 Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes; DNA-binding transcriptional repressor MarR 1587320 marR 8176151 marR Escherichia coli B str. REL606 DNA-binding transcriptional repressor MarR YP_003044692.1 1586886 D 413997 CDS YP_003044693.1 254161585 8178489 1587340..1587723 1 NC_012967.1 transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype; also activates sodA, zwf and micF; DNA-binding transcriptional activator MarA 1587723 marA 8178489 marA Escherichia coli B str. REL606 DNA-binding transcriptional activator MarA YP_003044693.1 1587340 D 413997 CDS YP_003044694.1 254161586 8176152 1587755..1587973 1 NC_012967.1 similar to b1532; hypothetical protein 1587973 marB 8176152 marB Escherichia coli B str. REL606 hypothetical protein YP_003044694.1 1587755 D 413997 CDS YP_003044695.1 254161587 8176153 complement(1588004..1588903) 1 NC_012967.1 similar to b1533; O-acetylserine/cysteine export protein 1588903 eamA 8176153 eamA Escherichia coli B str. REL606 O-acetylserine/cysteine export protein YP_003044695.1 1588004 R 413997 CDS YP_003044696.1 254161588 8176154 1589098..1590285 1 NC_012967.1 YdeF; uncharacterized member of the major facilitator superfamily (MFS) of transporters; putative MFS-type transporter YdeE 1590285 ydeE 8176154 ydeE Escherichia coli B str. REL606 putative MFS-type transporter YdeE YP_003044696.1 1589098 D 413997 CDS YP_003044697.1 254161589 8176155 complement(1590726..1591616) 1 NC_012967.1 similar to b1535; hypothetical protein 1591616 ydeH 8176155 ydeH Escherichia coli B str. REL606 hypothetical protein YP_003044697.1 1590726 R 413997 CDS YP_003044698.1 254161590 8176156 complement(1591871..1592263) 1 NC_012967.1 similar to b1536; hypothetical protein 1592263 ydeI 8176156 ydeI Escherichia coli B str. REL606 hypothetical protein YP_003044698.1 1591871 R 413997 CDS YP_003044699.1 254161591 8176157 1592539..1593057 1 NC_012967.1 similar to b1537; competence damage-inducible protein A 1593057 ydeJ 8176157 ydeJ Escherichia coli B str. REL606 competence damage-inducible protein A YP_003044699.1 1592539 D 413997 CDS YP_003044700.1 254161592 8179041 complement(1593101..1595146) 1 NC_012967.1 similar to b1538; dipeptidyl carboxypeptidase II 1595146 dcp 8179041 dcp Escherichia coli B str. REL606 dipeptidyl carboxypeptidase II YP_003044700.1 1593101 R 413997 CDS YP_003044701.1 254161593 8179042 1595283..1596029 1 NC_012967.1 NADP(+)-dependent; catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine; 3-hydroxy acid dehydrogenase 1596029 ydfG 8179042 ydfG Escherichia coli B str. REL606 3-hydroxy acid dehydrogenase YP_003044701.1 1595283 D 413997 CDS YP_003044702.1 254161594 8176158 1596118..1596804 1 NC_012967.1 similar to b1540; putative DNA-binding transcriptional regulator 1596804 ydfH 8176158 ydfH Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003044702.1 1596118 D 413997 CDS YP_003044703.1 254161595 8176159 1596981..1597184 1 NC_012967.1 similar to b1541; hypothetical protein 1597184 ydfZ 8176159 ydfZ Escherichia coli B str. REL606 hypothetical protein YP_003044703.1 1596981 D 413997 CDS YP_003044704.1 254161596 8176160 complement(1597220..1598680) 1 NC_012967.1 similar to b1542; putative mannonate dehydrogenase 1598680 ydfI 8176160 ydfI Escherichia coli B str. REL606 putative mannonate dehydrogenase YP_003044704.1 1597220 R 413997 CDS YP_003044705.1 254161597 8176161 complement(1598769..1600052) 1 NC_012967.1 similar to b1543; putative transporter 1600052 ydfJ 8176161 ydfJ Escherichia coli B str. REL606 putative transporter YP_003044705.1 1598769 R 413997 CDS YP_003044706.1 254161598 8176162 1600805..1601071 1 NC_012967.1 similar to b1544; putative DNA-binding transcriptional regulator 1601071 ydfK 8176162 ydfK Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003044706.1 1600805 D 413997 CDS YP_003044707.1 254161599 8176163 1601387..1601977 1 NC_012967.1 similar to b1545; putative site-specific recombinase 1601977 pinQ 8176163 pinQ Escherichia coli B str. REL606 putative site-specific recombinase YP_003044707.1 1601387 D 413997 CDS YP_003044708.1 254161600 8176164 complement(1602205..1602498) 1 NC_012967.1 hypothetical protein 1602498 8176164 ECB_01505 Escherichia coli B str. REL606 hypothetical protein YP_003044708.1 1602205 R 413997 CDS YP_003044709.1 254161601 8176165 complement(1602509..1603213) 1 NC_012967.1 hypothetical protein 1603213 8176165 ECB_01506 Escherichia coli B str. REL606 hypothetical protein YP_003044709.1 1602509 R 413997 CDS YP_003044710.1 254161602 8176166 complement(1603223..1603504) 1 NC_012967.1 hypothetical protein 1603504 8176166 ECB_01507 Escherichia coli B str. REL606 hypothetical protein YP_003044710.1 1603223 R 413997 CDS YP_003044711.1 254161603 8176167 complement(1603504..1605882) 1 NC_012967.1 similar to b1372; putative tail fiber protein 1605882 stfR 8176167 stfR Escherichia coli B str. REL606 putative tail fiber protein YP_003044711.1 1603504 R 413997 CDS YP_003044712.1 254161604 8179043 complement(1605947..1606546) 1 NC_012967.1 similar to b1369-b1370; hypothetical protein 1606546 lomR 8179043 lomR Escherichia coli B str. REL606 hypothetical protein YP_003044712.1 1605947 R 413997 CDS YP_003044713.1 254161605 8179044 complement(1606613..1607932) 1 NC_012967.1 putative tail component of prophage 1607932 8179044 ECB_01510 Escherichia coli B str. REL606 putative tail component of prophage YP_003044713.1 1606613 R 413997 CDS YP_003044714.1 254161606 8176168 1607973..1608281 1 NC_012967.1 putative transposase-related protein 1608281 insE-3 8176168 insE-3 Escherichia coli B str. REL606 putative transposase-related protein YP_003044714.1 1607973 D 413997 CDS YP_003044715.1 254161607 8178490 1608278..1609144 1 NC_012967.1 putative transposase for IS3 1609144 insF-3 8178490 insF-3 Escherichia coli B str. REL606 putative transposase for IS3 YP_003044715.1 1608278 D 413997 CDS YP_003044716.1 254161608 8176169 complement(1609298..1609504) 1 NC_012967.1 similar to b0559; hypothetical protein 1609504 ybcW 8176169 ybcW Escherichia coli B str. REL606 hypothetical protein YP_003044716.1 1609298 R 413997 CDS YP_003044717.1 254161609 8176170 complement(1609800..1609973) 1 NC_012967.1 similar to b1550; hypothetical protein 1609973 gnsB 8176170 gnsB Escherichia coli B str. REL606 hypothetical protein YP_003044717.1 1609800 R 413997 CDS YP_003044718.1 254161610 8176171 complement(1610146..1610301) 1 NC_012967.1 similar to b1551; hypothetical protein 1610301 ynfN 8176171 ynfN Escherichia coli B str. REL606 hypothetical protein YP_003044718.1 1610146 R 413997 CDS YP_003044719.1 254161611 8176172 complement(1610449..1610703) 1 NC_012967.1 putative cold-shock protein 1610703 8176172 ECB_01516 Escherichia coli B str. REL606 putative cold-shock protein YP_003044719.1 1610449 R 413997 CDS YP_003044720.1 254161612 8176173 complement(1610648..1610860) 1 NC_012967.1 similar to b1552; cold shock protein 1610860 cspI 8176173 cspI Escherichia coli B str. REL606 cold shock protein YP_003044720.1 1610648 R 413997 CDS YP_003044721.1 254161613 8176174 complement(1611224..1611721) 1 NC_012967.1 similar to b1553; hypothetical protein 1611721 ydfP 8176174 ydfP Escherichia coli B str. REL606 hypothetical protein YP_003044721.1 1611224 R 413997 CDS YP_003044722.1 254161614 8179045 complement(1611718..1612251) 1 NC_012967.1 similar to b1554; putative lysozyme 1612251 ydfQ-2 8179045 ydfQ-2 Escherichia coli B str. REL606 putative lysozyme YP_003044722.1 1611718 R 413997 CDS YP_003044723.1 254161615 8176175 complement(1612573..1613124) 1 NC_012967.1 similar to b1555; hypothetical protein 1613124 ydfR 8176175 ydfR Escherichia coli B str. REL606 hypothetical protein YP_003044723.1 1612573 R 413997 CDS YP_003044724.1 254161616 8179046 complement(1613129..1613344) 1 NC_012967.1 similar to b1556; putative S lysis protein 1613344 essQ 8179046 essQ Escherichia coli B str. REL606 putative S lysis protein YP_003044724.1 1613129 R 413997 CDS YP_003044725.1 254161617 8179047 complement(1613535..1614248) 1 NC_012967.1 putative AraC-type regulatory protein encoded in prophage 1614248 8179047 ECB_01522 Escherichia coli B str. REL606 putative AraC-type regulatory protein encoded in prophage YP_003044725.1 1613535 R 413997 CDS YP_003044726.1 254161618 8176176 complement(1614655..1615377) 1 NC_012967.1 putative pathogenicity island protein 1615377 8176176 ECB_01523 Escherichia coli B str. REL606 putative pathogenicity island protein YP_003044726.1 1614655 R 413997 CDS YP_003044727.1 254161619 8178491 1615527..1615835 1 NC_012967.1 putative transposase-related protein 1615835 insE-4 8178491 insE-4 Escherichia coli B str. REL606 putative transposase-related protein YP_003044727.1 1615527 D 413997 CDS YP_003044728.1 254161620 8176177 1615832..1616698 1 NC_012967.1 putative transposase for IS3 1616698 insF-4 8176177 insF-4 Escherichia coli B str. REL606 putative transposase for IS3 YP_003044728.1 1615832 D 413997 CDS YP_003044729.1 254161621 8176179 1617068..1617592 1 NC_012967.1 lipocalin; globomycin-sensitive outer membrane lipoprotein; outer membrane lipoprotein Blc 1617592 8176179 ECB_01527 Escherichia coli B str. REL606 outer membrane lipoprotein Blc YP_003044729.1 1617068 D 413997 CDS YP_003044730.1 254161622 8176180 complement(1617748..1618128) 1 NC_012967.1 from lambdoid prophage DLP12; antitermination protein Q-like protein 1618128 8176180 ECB_01528 Escherichia coli B str. REL606 antitermination protein Q-like protein YP_003044730.1 1617748 R 413997 CDS YP_003044731.1 254161623 8176181 complement(1618143..1618721) 1 NC_012967.1 similar to b1560; hypothetical protein 1618721 ydfU 8176181 ydfU Escherichia coli B str. REL606 hypothetical protein YP_003044731.1 1618143 R 413997 CDS YP_003044732.1 254161624 8176182 complement(1618795..1619073) 1 NC_012967.1 hypothetical protein 1619073 8176182 ECB_01530 Escherichia coli B str. REL606 hypothetical protein YP_003044732.1 1618795 R 413997 CDS YP_003044733.1 254161625 8178492 complement(1619140..1619391) 1 NC_012967.1 similar to b1561; hypothetical protein 1619391 rem 8178492 rem Escherichia coli B str. REL606 hypothetical protein YP_003044733.1 1619140 R 413997 CDS YP_003044734.1 254161626 8176183 complement(1619608..1619763) 1 NC_012967.1 similar to b1562; small toxic polypeptide 1619763 hokD 8176183 hokD Escherichia coli B str. REL606 small toxic polypeptide YP_003044734.1 1619608 R 413997 CDS YP_003044735.1 254161627 8179048 complement(1619975..1620064) 1 NC_012967.1 hypothetical protein 1620064 8179048 ECB_01533 Escherichia coli B str. REL606 hypothetical protein YP_003044735.1 1619975 R 413997 CDS YP_003044736.1 254161628 8179049 complement(1620376..1621155) 1 NC_012967.1 hypothetical protein 1621155 8179049 ECB_01534 Escherichia coli B str. REL606 hypothetical protein YP_003044736.1 1620376 R 413997 CDS YP_003044737.1 254161629 8176184 complement(1621325..1621747) 1 NC_012967.1 hypothetical protein 1621747 8176184 ECB_01535 Escherichia coli B str. REL606 hypothetical protein YP_003044737.1 1621325 R 413997 CDS YP_003044738.1 254161630 8178493 complement(1621788..1622807) 1 NC_012967.1 hypothetical protein 1622807 8178493 ECB_01536 Escherichia coli B str. REL606 hypothetical protein YP_003044738.1 1621788 R 413997 CDS YP_003044739.1 254161631 8176185 complement(1622734..1623195) 1 NC_012967.1 similar to b1568; hypothetical protein 1623195 ydfX 8176185 ydfX Escherichia coli B str. REL606 hypothetical protein YP_003044739.1 1622734 R 413997 CDS YP_003044740.1 254161632 8176186 complement(1623239..1623469) 1 NC_012967.1 DNA-binding transcriptional regulator DicC 1623469 dicC 8176186 dicC Escherichia coli B str. REL606 DNA-binding transcriptional regulator DicC YP_003044740.1 1623239 R 413997 CDS YP_003044741.1 254161633 8176187 1623547..1623954 1 NC_012967.1 The transcriptional repressor of DicA (divison cell) has a hypothetical DNA binding domain. It represses the transcription of dicB and dicC, but its specific role in cellular replication and mode of action are still unknown.; transcriptional repressor DicA 1623954 8176187 ECB_01539 Escherichia coli B str. REL606 transcriptional repressor DicA YP_003044741.1 1623547 D 413997 CDS YP_003044742.1 254161634 8176188 1624069..1624275 1 NC_012967.1 hypothetical protein 1624275 8176188 ECB_01540 Escherichia coli B str. REL606 hypothetical protein YP_003044742.1 1624069 D 413997 CDS YP_003044743.1 254161635 8176189 1624287..1624652 1 NC_012967.1 hypothetical protein 1624652 8176189 ECB_01541 Escherichia coli B str. REL606 hypothetical protein YP_003044743.1 1624287 D 413997 CDS YP_003044744.1 254161636 8176190 complement(1624621..1624908) 1 NC_012967.1 hypothetical protein 1624908 8176190 ECB_01542 Escherichia coli B str. REL606 hypothetical protein YP_003044744.1 1624621 R 413997 CDS YP_003044745.1 254161637 8178494 1625324..1625512 1 NC_012967.1 similar to b1575; cell division inhibition protein 1625512 dicB 8178494 dicB Escherichia coli B str. REL606 cell division inhibition protein YP_003044745.1 1625324 D 413997 CDS YP_003044746.1 254161638 8176191 1625509..1625700 1 NC_012967.1 similar to b1576; hypothetical protein 1625700 ydfD 8176191 ydfD Escherichia coli B str. REL606 hypothetical protein YP_003044746.1 1625509 D 413997 CDS YP_003044747.1 254161639 8176192 1625794..1628265 1 NC_012967.1 similar to b1577; hypothetical protein 1628265 ydfE 8176192 ydfE Escherichia coli B str. REL606 hypothetical protein YP_003044747.1 1625794 D 413997 CDS YP_003044748.1 254161640 8176193 1628338..1628589 1 NC_012967.1 Excisionase 1628589 8176193 ECB_01546 Escherichia coli B str. REL606 Excisionase YP_003044748.1 1628338 D 413997 CDS YP_003044749.1 254161641 8176195 complement(1630091..1631110) 1 NC_012967.1 similar to b1580; putative dehydrogenase 1631110 rspB 8176195 rspB Escherichia coli B str. REL606 putative dehydrogenase YP_003044749.1 1630091 R 413997 CDS YP_003044750.1 254161642 8176196 complement(1631122..1632336) 1 NC_012967.1 similar to b1581; putative dehydratase 1632336 rspA 8176196 rspA Escherichia coli B str. REL606 putative dehydratase YP_003044750.1 1631122 R 413997 CDS YP_003044751.1 254161643 8176197 complement(1632542..1632868) 1 NC_012967.1 similar to b1582; hypothetical protein 1632868 ynfA 8176197 ynfA Escherichia coli B str. REL606 hypothetical protein YP_003044751.1 1632542 R 413997 CDS YP_003044752.1 254161644 8176198 1633003..1633344 1 NC_012967.1 similar to b1583; hypothetical protein 1633344 ynfB 8176198 ynfB Escherichia coli B str. REL606 hypothetical protein YP_003044752.1 1633003 D 413997 CDS YP_003044753.1 254161645 8176199 1633379..1633939 1 NC_012967.1 similar to b1584; spermidine N1-acetyltransferase 1633939 speG 8176199 speG Escherichia coli B str. REL606 spermidine N1-acetyltransferase YP_003044753.1 1633379 D 413997 CDS YP_003044754.1 254161646 8176200 complement(1633942..1634652) 1 NC_012967.1 similar to b1585; hypothetical protein 1634652 ynfC 8176200 ynfC Escherichia coli B str. REL606 hypothetical protein YP_003044754.1 1633942 R 413997 CDS YP_003044755.1 254161647 8178496 1634760..1635065 1 NC_012967.1 similar to b1586; hypothetical protein 1635065 ynfD 8178496 ynfD Escherichia coli B str. REL606 hypothetical protein YP_003044755.1 1634760 D 413997 CDS YP_003044756.1 254161648 8176201 1635264..1637690 1 NC_012967.1 similar to b1587; oxidoreductase subunit 1637690 ynfE 8176201 ynfE Escherichia coli B str. REL606 oxidoreductase subunit YP_003044756.1 1635264 D 413997 CDS YP_003044757.1 254161649 8176202 1637751..1640174 1 NC_012967.1 similar to b1588; oxidoreductase subunit 1640174 ynfF 8176202 ynfF Escherichia coli B str. REL606 oxidoreductase subunit YP_003044757.1 1637751 D 413997 CDS YP_003044758.1 254161650 8176203 1640185..1640802 1 NC_012967.1 similar to b1589; oxidoreductase, Fe-S subunit 1640802 ynfG 8176203 ynfG Escherichia coli B str. REL606 oxidoreductase, Fe-S subunit YP_003044758.1 1640185 D 413997 CDS YP_003044759.1 254161651 8176204 1640804..1641658 1 NC_012967.1 similar to b1590; oxidoreductase, membrane subunit 1641658 ynfH 8176204 ynfH Escherichia coli B str. REL606 oxidoreductase, membrane subunit YP_003044759.1 1640804 D 413997 CDS YP_003044760.1 254161652 8176205 1641701..1642315 1 NC_012967.1 binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane; twin-argninine leader-binding protein DmsD 1642315 ynfI 8176205 ynfI Escherichia coli B str. REL606 twin-argninine leader-binding protein DmsD YP_003044760.1 1641701 D 413997 CDS YP_003044761.1 254161653 8178497 1642510..1643766 1 NC_012967.1 similar to b1592; putative voltage-gated ClC-type chloride channel ClcB 1643766 ynfJ 8178497 ynfJ Escherichia coli B str. REL606 putative voltage-gated ClC-type chloride channel ClcB YP_003044761.1 1642510 D 413997 CDS YP_003044762.1 254161654 8176206 complement(1643719..1644414) 1 NC_012967.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; putative dithiobiotin synthetase 1644414 ynfK 8176206 ynfK Escherichia coli B str. REL606 putative dithiobiotin synthetase YP_003044762.1 1643719 R 413997 CDS YP_003044763.1 254161655 8176207 complement(1644539..1645759) 1 NC_012967.1 similar to b1594; DNA-binding transcriptional repressor 1645759 mlc 8176207 mlc Escherichia coli B str. REL606 DNA-binding transcriptional repressor YP_003044763.1 1644539 R 413997 CDS YP_003044764.1 254161656 8178498 complement(1645894..1646787) 1 NC_012967.1 similar to b1595; putative DNA-binding transcriptional regulator 1646787 ynfL 8178498 ynfL Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003044764.1 1645894 R 413997 CDS YP_003044765.1 254161657 8176208 1646894..1648147 1 NC_012967.1 similar to b1596; putative transporter 1648147 ynfM 8176208 ynfM Escherichia coli B str. REL606 putative transporter YP_003044765.1 1646894 D 413997 CDS YP_003044766.1 254161658 8176209 1648571..1648879 1 NC_012967.1 required for growth and survival under moderately acid conditions; acid shock protein precursor 1648879 asr 8176209 asr Escherichia coli B str. REL606 acid shock protein precursor YP_003044766.1 1648571 D 413997 CDS YP_003044767.1 254161659 8176210 1649155..1649976 1 NC_012967.1 similar to b1598; putative peptidase 1649976 ydgD 8176210 ydgD Escherichia coli B str. REL606 putative peptidase YP_003044767.1 1649155 D 413997 CDS YP_003044768.1 254161660 8176211 complement(1650015..1650344) 1 NC_012967.1 with MdtJ is involved in resistance to deoxycholate, nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtI 1650344 ydgE 8176211 ydgE Escherichia coli B str. REL606 multidrug efflux system protein MdtI YP_003044768.1 1650015 R 413997 CDS YP_003044769.1 254161661 8178499 complement(1650331..1650696) 1 NC_012967.1 with MdtI is involved in resistance to deoxycholate , nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtJ 1650696 ydgF 8178499 ydgF Escherichia coli B str. REL606 multidrug efflux system protein MdtJ YP_003044769.1 1650331 R 413997 CDS YP_003044770.1 254161662 8176212 1651108..1652142 1 NC_012967.1 transport of quorum-sensing signal; mutations in this gene alters the transport of the quorum-sensing signal autoinducer 2 (AI-2) which affects expression of a large number of genes; putative transport protein 1652142 tqsA 8176212 tqsA Escherichia coli B str. REL606 putative transport protein YP_003044770.1 1651108 D 413997 CDS YP_003044771.1 254161663 8176213 complement(1652167..1653555) 1 NC_012967.1 catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme; pyridine nucleotide transhydrogenase 1653555 pntB 8176213 pntB Escherichia coli B str. REL606 pyridine nucleotide transhydrogenase YP_003044771.1 1652167 R 413997 CDS YP_003044772.1 254161664 8176214 complement(1653566..1655098) 1 NC_012967.1 forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm; NAD(P) transhydrogenase subunit alpha 1655098 pntA 8176214 pntA Escherichia coli B str. REL606 NAD(P) transhydrogenase subunit alpha YP_003044772.1 1653566 R 413997 CDS YP_003044773.1 254161665 8176215 1655622..1656566 1 NC_012967.1 similar to b1604; hypothetical protein 1656566 ydgH 8176215 ydgH Escherichia coli B str. REL606 hypothetical protein YP_003044773.1 1655622 D 413997 CDS YP_003044774.1 254161666 8176216 1656752..1658134 1 NC_012967.1 similar to b1605; putative arginine/ornithine antiporter transporter 1658134 ydgI 8176216 ydgI Escherichia coli B str. REL606 putative arginine/ornithine antiporter transporter YP_003044774.1 1656752 D 413997 CDS YP_003044775.1 254161667 8178500 1658171..1658893 1 NC_012967.1 similar to b1606; short chain dehydrogenase 1658893 ydgB 8178500 ydgB Escherichia coli B str. REL606 short chain dehydrogenase YP_003044775.1 1658171 D 413997 CDS YP_003044776.1 254161668 8176217 complement(1658890..1659225) 1 NC_012967.1 similar to b1607; inner membrane protein associated with alginate biosynthesis 1659225 ydgC 8176217 ydgC Escherichia coli B str. REL606 inner membrane protein associated with alginate biosynthesis YP_003044776.1 1658890 R 413997 CDS YP_003044777.1 254161669 8176218 1659345..1660073 1 NC_012967.1 response regulator in two-component regulatory system with RstB; DNA-binding transcriptional regulator RstA 1660073 rstA 8176218 rstA Escherichia coli B str. REL606 DNA-binding transcriptional regulator RstA YP_003044777.1 1659345 D 413997 CDS YP_003044778.1 254161670 8178501 1660077..1661378 1 NC_012967.1 similar to b1609; sensor protein RstB 1661378 rstB 8178501 rstB Escherichia coli B str. REL606 sensor protein RstB YP_003044778.1 1660077 D 413997 CDS YP_003044779.1 254161671 8176219 1661454..1662383 1 NC_012967.1 binds to DNA replication terminator sequences to prevent passage of replication forks; DNA replication terminus site-binding protein 1662383 tus 8176219 tus Escherichia coli B str. REL606 DNA replication terminus site-binding protein YP_003044779.1 1661454 D 413997 CDS YP_003044780.1 254161672 8178502 complement(1662380..1663783) 1 NC_012967.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 1663783 fumC 8178502 fumC Escherichia coli B str. REL606 fumarate hydratase YP_003044780.1 1662380 R 413997 CDS YP_003044781.1 254161673 8176220 complement(1663926..1665572) 1 NC_012967.1 similar to b1612; fumarate hydratase (fumarase A), aerobic Class I 1665572 fumA 8176220 fumA Escherichia coli B str. REL606 fumarate hydratase (fumarase A), aerobic Class I YP_003044781.1 1663926 R 413997 CDS YP_003044782.1 254161674 8176221 1665771..1666946 1 NC_012967.1 similar to b1613; mannose-6-phosphate isomerase 1666946 manA 8176221 manA Escherichia coli B str. REL606 mannose-6-phosphate isomerase YP_003044782.1 1665771 D 413997 CDS YP_003044783.1 254161675 8176222 1667047..1668555 1 NC_012967.1 similar to b1614; hypothetical protein 1668555 ydgA 8176222 ydgA Escherichia coli B str. REL606 hypothetical protein YP_003044783.1 1667047 D 413997 CDS YP_003044784.1 254161676 8176223 complement(1668781..1670046) 1 NC_012967.1 similar to b1615; putative outer membrane porin protein 1670046 uidC 8176223 uidC Escherichia coli B str. REL606 putative outer membrane porin protein YP_003044784.1 1668781 R 413997 CDS YP_003044785.1 254161677 8176224 complement(1670085..1671458) 1 NC_012967.1 similar to b1616; glucuronide transporter 1671458 uidB 8176224 uidB Escherichia coli B str. REL606 glucuronide transporter YP_003044785.1 1670085 R 413997 CDS YP_003044786.1 254161678 8176225 complement(1671455..1673266) 1 NC_012967.1 similar to b1617; beta-D-glucuronidase 1673266 uidA 8176225 uidA Escherichia coli B str. REL606 beta-D-glucuronidase YP_003044786.1 1671455 R 413997 CDS YP_003044787.1 254161679 8176226 complement(1673657..1674247) 1 NC_012967.1 similar to b1618; DNA-binding transcriptional repressor 1674247 uidR 8176226 uidR Escherichia coli B str. REL606 DNA-binding transcriptional repressor YP_003044787.1 1673657 R 413997 CDS YP_003044788.1 254161680 8179050 complement(1674468..1675235) 1 NC_012967.1 Acts on the hydroxyl group at position 7 of the steroid frame; 7-alpha-hydroxysteroid dehydrogenase 1675235 hdhA 8179050 hdhA Escherichia coli B str. REL606 7-alpha-hydroxysteroid dehydrogenase YP_003044788.1 1674468 R 413997 CDS YP_003044789.1 254161681 8176227 complement(1675346..1676374) 1 NC_012967.1 regulates malXY which are involved in maltose-glucose transport; DNA-binding transcriptional repressor MalI 1676374 malI 8176227 malI Escherichia coli B str. REL606 DNA-binding transcriptional repressor MalI YP_003044789.1 1675346 R 413997 CDS YP_003044790.1 254161682 8176228 1676549..1678141 1 NC_012967.1 phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS); catalyzes the phosphorylation of maltose and glucose concomitant with their translocation across the cell membrane; component IIB catalyzes the phosphorylation of the sugar molecule; IIC forms the translocation channel and contains the substrate specific binding site; bifunctional PTS system maltose and glucose-specific transporter subunits IICB 1678141 malX 8176228 malX Escherichia coli B str. REL606 bifunctional PTS system maltose and glucose-specific transporter subunits IICB YP_003044790.1 1676549 D 413997 CDS YP_003044791.1 254161683 8176229 1678151..1679323 1 NC_012967.1 similar to b1622; bifunctional beta-cystathionase, PLP-dependent/ regulator of maltose regulon 1679323 malY 8176229 malY Escherichia coli B str. REL606 bifunctional beta-cystathionase, PLP-dependent/ regulator of maltose regulon YP_003044791.1 1678151 D 413997 CDS YP_003044792.1 254161684 8176230 1679427..1680428 1 NC_012967.1 catalyzes the formation of inosine from adenosine; adenosine deaminase 1680428 add 8176230 add Escherichia coli B str. REL606 adenosine deaminase YP_003044792.1 1679427 D 413997 CDS YP_003044793.1 254161685 8176231 complement(1680462..1681502) 1 NC_012967.1 similar to b1624; putative oxidoreductase 1681502 ydgJ 8176231 ydgJ Escherichia coli B str. REL606 putative oxidoreductase YP_003044793.1 1680462 R 413997 CDS YP_003044794.1 254161686 8176232 1681745..1681870 1 NC_012967.1 similar to b4409; beta-lactam resistance membrane protein 1681870 blr 8176232 blr Escherichia coli B str. REL606 beta-lactam resistance membrane protein YP_003044794.1 1681745 D 413997 CDS YP_003044795.1 254161687 8179051 1682143..1682358 1 NC_012967.1 YdgT; in E. coli, when complexed with H-NS or StpA binds a 26 base-pair DNA sequence of oriC; seems to play a role in optimizing the activity of oriC; non-essential; Hha protein paralog; in an hha mutant background, cnu is overexpressed and can compensate hha-induced phenotypes; oriC-binding nucleoid-associated protein 1682358 ydgT 8179051 ydgT Escherichia coli B str. REL606 oriC-binding nucleoid-associated protein YP_003044795.1 1682143 D 413997 CDS YP_003044796.1 254161688 8176233 1682444..1682884 1 NC_012967.1 similar to b1626; inner membrane protein 1682884 ydgK 8176233 ydgK Escherichia coli B str. REL606 inner membrane protein YP_003044796.1 1682444 D 413997 CDS YP_003044797.1 254161689 8176234 1682961..1683542 1 NC_012967.1 similar to b1627; Na(+)-translocating NADH-quinone reductase subunit E 1683542 rnfA 8176234 rnfA Escherichia coli B str. REL606 Na(+)-translocating NADH-quinone reductase subunit E YP_003044797.1 1682961 D 413997 CDS YP_003044798.1 254161690 8176235 1683542..1684120 1 NC_012967.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfB 1684120 rnfB 8176235 rnfB Escherichia coli B str. REL606 electron transport complex protein RnfB YP_003044798.1 1683542 D 413997 CDS YP_003044799.1 254161691 8176236 1684113..1686335 1 NC_012967.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfC 1686335 rnfC 8176236 rnfC Escherichia coli B str. REL606 electron transport complex protein RnfC YP_003044799.1 1684113 D 413997 CDS YP_003044800.1 254161692 8179052 1686336..1687394 1 NC_012967.1 RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents; electron transport complex protein RnfD 1687394 rnfD 8179052 rnfD Escherichia coli B str. REL606 electron transport complex protein RnfD YP_003044800.1 1686336 D 413997 CDS YP_003044801.1 254161693 8176237 1687398..1688018 1 NC_012967.1 part of membrane-bound complex hought to be involved in electron transport to nitrogen; electron transport complex protein RnfG 1688018 rnfG 8176237 rnfG Escherichia coli B str. REL606 electron transport complex protein RnfG YP_003044801.1 1687398 D 413997 CDS YP_003044802.1 254161694 8176238 1688022..1688717 1 NC_012967.1 in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase; electron transport complex RsxE subunit 1688717 rnfE 8176238 rnfE Escherichia coli B str. REL606 electron transport complex RsxE subunit YP_003044802.1 1688022 D 413997 CDS YP_003044803.1 254161695 8176239 1688717..1689352 1 NC_012967.1 DNA-(apurinic or apyrimidinic site) lyase; has apurinic or apyrimidinic endonuclease activity and DNA N-glycosylase activity; removed damaged DNA at cytosines, thymines and guanines; endonuclease III 1689352 nth 8176239 nth Escherichia coli B str. REL606 endonuclease III YP_003044803.1 1688717 D 413997 CDS YP_003044804.1 254161696 8176240 1689963..1691465 1 NC_012967.1 mutations in this gene confer resistance to the toxic peptide alafosfalin in Salmonella typhimurium; member of proton-dependent oligopeptide transport (POT) system family; in Escherichia coli this gene is regulated by OmpR although not via osmoregulation; putative tripeptide transporter permease 1691465 tppB 8176240 tppB Escherichia coli B str. REL606 putative tripeptide transporter permease YP_003044804.1 1689963 D 413997 CDS YP_003044805.1 254161697 8179053 1691571..1692176 1 NC_012967.1 similar to b1635; glutathionine S-transferase 1692176 gst 8179053 gst Escherichia coli B str. REL606 glutathionine S-transferase YP_003044805.1 1691571 D 413997 CDS YP_003044806.1 254161698 8176241 complement(1692220..1693083) 1 NC_012967.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxamine kinase 1693083 pdxY 8176241 pdxY Escherichia coli B str. REL606 pyridoxamine kinase YP_003044806.1 1692220 R 413997 CDS YP_003044807.1 254161699 8176242 complement(1693142..1694416) 1 NC_012967.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 1694416 tyrS 8176242 tyrS Escherichia coli B str. REL606 tyrosyl-tRNA synthetase YP_003044807.1 1693142 R 413997 CDS YP_003044808.1 254161700 8179054 complement(1694545..1695201) 1 NC_012967.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase 1695201 pdxH 8179054 pdxH Escherichia coli B str. REL606 pyridoxamine 5'-phosphate oxidase YP_003044808.1 1694545 R 413997 CDS YP_003044809.1 254161701 8176243 complement(1695260..1695589) 1 NC_012967.1 MliC; membrane-bound lysozyme inhibitor of c-type lysozyme; lysozyme inhibitor 1695589 ydhA 8176243 ydhA Escherichia coli B str. REL606 lysozyme inhibitor YP_003044809.1 1695260 R 413997 CDS YP_003044810.1 254161702 8176244 complement(1695687..1696796) 1 NC_012967.1 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling; anhydro-N-acetylmuramic acid kinase 1696796 anmK 8176244 anmK Escherichia coli B str. REL606 anhydro-N-acetylmuramic acid kinase YP_003044810.1 1695687 R 413997 CDS YP_003044811.1 254161703 8176245 1697070..1697537 1 NC_012967.1 similar to b1641; outer membrane lipoprotein 1697537 slyB 8176245 slyB Escherichia coli B str. REL606 outer membrane lipoprotein YP_003044811.1 1697070 D 413997 CDS YP_003044812.1 254161704 8176246 complement(1697584..1698018) 1 NC_012967.1 Transcription regulator that can both activate or repress expression; transcriptional regulator SlyA 1698018 slyA 8176246 slyA Escherichia coli B str. REL606 transcriptional regulator SlyA YP_003044812.1 1697584 R 413997 CDS YP_003044813.1 254161705 8179055 1698219..1698455 1 NC_012967.1 similar to b1643; putative inner membrane protein 1698455 ydhI 8179055 ydhI Escherichia coli B str. REL606 putative inner membrane protein YP_003044813.1 1698219 D 413997 CDS YP_003044814.1 254161706 8176247 1698458..1699315 1 NC_012967.1 similar to b1644; undecaprenyl pyrophosphate phosphatase 1699315 ydhJ 8176247 ydhJ Escherichia coli B str. REL606 undecaprenyl pyrophosphate phosphatase YP_003044814.1 1698458 D 413997 CDS YP_003044815.1 254161707 8178503 1699315..1701327 1 NC_012967.1 similar to b1645; inner membrane protein 1701327 ydhK 8178503 ydhK Escherichia coli B str. REL606 inner membrane protein YP_003044815.1 1699315 D 413997 CDS YP_003044816.1 254161708 8176248 complement(1701328..1701849) 1 NC_012967.1 SodC; copper and zinc binding; converts superoxide radicals to hydrogen peroxide and water; superoxide dismutase 1701849 sodC 8176248 sodC Escherichia coli B str. REL606 superoxide dismutase YP_003044816.1 1701328 R 413997 CDS YP_003044817.1 254161709 8176249 complement(1701930..1702826) 1 NC_012967.1 similar to b1647; putative oxidoreductase 1702826 ydhF 8176249 ydhF Escherichia coli B str. REL606 putative oxidoreductase YP_003044817.1 1701930 R 413997 CDS YP_003044818.1 254161710 8179056 complement(1702875..1703114) 1 NC_012967.1 similar to b1648; hypothetical protein 1703114 ydhL 8179056 ydhL Escherichia coli B str. REL606 hypothetical protein YP_003044818.1 1702875 R 413997 CDS YP_003044819.1 254161711 8176250 1703301..1703816 1 NC_012967.1 similar to b1649; putative DNA-binding transcriptional regulator 1703816 ydhM 8176250 ydhM Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003044819.1 1703301 D 413997 CDS YP_003044820.1 254161712 8178504 1703853..1704950 1 NC_012967.1 FMN-linked; catalyzes the formation of N-ethylsuccinimide from N-ethylmaleimide; N-ethylmaleimide reductase 1704950 nemA 8178504 nemA Escherichia coli B str. REL606 N-ethylmaleimide reductase YP_003044820.1 1703853 D 413997 CDS YP_003044821.1 254161713 8176251 1705031..1705438 1 NC_012967.1 Ni-dependent; catalyzes the formation of S-lactoylglutathione from methylglyoxal and glutathione; glyoxalase I 1705438 gloA 8176251 gloA Escherichia coli B str. REL606 glyoxalase I YP_003044821.1 1705031 D 413997 CDS YP_003044822.1 254161714 8176252 1705541..1706188 1 NC_012967.1 Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A); ribonuclease T 1706188 rnt 8176252 rnt Escherichia coli B str. REL606 ribonuclease T YP_003044822.1 1705541 D 413997 CDS YP_003044823.1 254161715 8176253 1706281..1710897 1 NC_012967.1 similar to the DNA and RNA helicase superfamily II and eukaryotic DEAD family of helicases; longest known protein in E. coli; putative ATP-dependent helicase Lhr 1710897 lhr 8176253 lhr Escherichia coli B str. REL606 putative ATP-dependent helicase Lhr YP_003044823.1 1706281 D 413997 CDS YP_003044824.1 254161716 8176254 complement(1710948..1711295) 1 NC_012967.1 similar to b1654; hypothetical protein 1711295 ydhD 8176254 ydhD Escherichia coli B str. REL606 hypothetical protein YP_003044824.1 1710948 R 413997 CDS YP_003044825.1 254161717 8179057 1711629..1712444 1 NC_012967.1 similar to b1655; putative lipoprotein 1712444 ydhO 8179057 ydhO Escherichia coli B str. REL606 putative lipoprotein YP_003044825.1 1711629 D 413997 CDS YP_003044826.1 254161718 8176255 1712572..1713153 1 NC_012967.1 SodB; iron binding; present under aerobic and anaerobic conditions; destroys free radicals; superoxide dismutase 1713153 sodB 8176255 sodB Escherichia coli B str. REL606 superoxide dismutase YP_003044826.1 1712572 D 413997 CDS YP_003044827.1 254161719 8178505 complement(1713388..1714557) 1 NC_012967.1 similar to b1657; putative transport protein (MFS family) 1714557 ydhP 8178505 ydhP Escherichia coli B str. REL606 putative transport protein (MFS family) YP_003044827.1 1713388 R 413997 CDS YP_003044828.1 254161720 8176256 complement(1714723..1714842) 1 NC_012967.1 membrane protein 1714842 8176256 ECB_01628 Escherichia coli B str. REL606 membrane protein YP_003044828.1 1714723 R 413997 CDS YP_003044829.1 254161721 8176257 1715111..1716136 1 NC_012967.1 binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers; DNA-binding transcriptional repressor PurR 1716136 purR 8176257 purR Escherichia coli B str. REL606 DNA-binding transcriptional repressor PurR YP_003044829.1 1715111 D 413997 CDS YP_003044830.1 254161722 8178506 complement(1716133..1717065) 1 NC_012967.1 similar to b1659; putative DNA-binding transcriptional regulator 1717065 ydhB 8178506 ydhB Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003044830.1 1716133 R 413997 CDS YP_003044831.1 254161723 8176258 1717178..1718389 1 NC_012967.1 uncharacterized member of the major facilitator superfamily (MFS); inner membrane transport protein YdhC 1718389 ydhC 8176258 ydhC Escherichia coli B str. REL606 inner membrane transport protein YdhC YP_003044831.1 1717178 D 413997 CDS YP_003044832.1 254161724 8178507 1718680..1719828 1 NC_012967.1 catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge; cyclopropane fatty acyl phospholipid synthase 1719828 cfa 8178507 cfa Escherichia coli B str. REL606 cyclopropane fatty acyl phospholipid synthase YP_003044832.1 1718680 D 413997 CDS YP_003044833.1 254161725 8176259 complement(1719868..1720509) 1 NC_012967.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 1720509 ribC 8176259 ribC Escherichia coli B str. REL606 riboflavin synthase subunit alpha YP_003044833.1 1719868 R 413997 CDS YP_003044834.1 254161726 8176260 1720724..1722097 1 NC_012967.1 NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones; multidrug efflux protein 1722097 norM 8176260 norM Escherichia coli B str. REL606 multidrug efflux protein YP_003044834.1 1720724 D 413997 CDS YP_003044835.1 254161727 8176261 complement(1722138..1723394) 1 NC_012967.1 similar to b1664; hypothetical protein 1723394 ydhQ 8176261 ydhQ Escherichia coli B str. REL606 hypothetical protein YP_003044835.1 1722138 R 413997 CDS YP_003044836.1 254161728 8176264 1723967..1724272 1 NC_012967.1 similar to b1667; hypothetical protein 1724272 ydhR 8176264 ydhR Escherichia coli B str. REL606 hypothetical protein YP_003044836.1 1723967 D 413997 CDS YP_003044837.1 254161729 8176265 1724398..1726002 1 NC_012967.1 similar to b1668; hypothetical protein 1726002 ydhS 8176265 ydhS Escherichia coli B str. REL606 hypothetical protein YP_003044837.1 1724398 D 413997 CDS YP_003044838.1 254161730 8176266 complement(1726014..1726826) 1 NC_012967.1 similar to b1669; hypothetical protein 1726826 ydhT 8176266 ydhT Escherichia coli B str. REL606 hypothetical protein YP_003044838.1 1726014 R 413997 CDS YP_003044839.1 254161731 8176267 complement(1726830..1727615) 1 NC_012967.1 similar to b1670; putative cytochrome 1727615 ydhU 8176267 ydhU Escherichia coli B str. REL606 putative cytochrome YP_003044839.1 1726830 R 413997 CDS YP_003044840.1 254161732 8178508 complement(1727612..1728280) 1 NC_012967.1 similar to b1671; putative 4Fe-4S ferridoxin-type protein 1728280 ydhX 8178508 ydhX Escherichia coli B str. REL606 putative 4Fe-4S ferridoxin-type protein YP_003044840.1 1727612 R 413997 CDS YP_003044841.1 254161733 8176268 complement(1728344..1728991) 1 NC_012967.1 similar to b1672; hypothetical protein 1728991 ydhW 8176268 ydhW Escherichia coli B str. REL606 hypothetical protein YP_003044841.1 1728344 R 413997 CDS YP_003044842.1 254161734 8176269 complement(1728995..1731097) 1 NC_012967.1 similar to b1673; putative oxidoreductase 1731097 ydhV 8176269 ydhV Escherichia coli B str. REL606 putative oxidoreductase YP_003044842.1 1728995 R 413997 CDS YP_003044843.1 254161735 8176270 complement(1731118..1731744) 1 NC_012967.1 similar to b1674; hypothetical protein 1731744 ydhY 8176270 ydhY Escherichia coli B str. REL606 hypothetical protein YP_003044843.1 1731118 R 413997 CDS YP_003044844.1 254161736 8176271 complement(1732199..1732408) 1 NC_012967.1 similar to b1675; hypothetical protein 1732408 ydhZ 8176271 ydhZ Escherichia coli B str. REL606 hypothetical protein YP_003044844.1 1732199 R 413997 CDS YP_003044845.1 254161737 8176272 1732965..1734377 1 NC_012967.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1734377 pykF 8176272 pykF Escherichia coli B str. REL606 pyruvate kinase YP_003044845.1 1732965 D 413997 CDS YP_003044846.1 254161738 8176273 1734688..1734924 1 NC_012967.1 similar to b1677; murein lipoprotein 1734924 lpp 8176273 lpp Escherichia coli B str. REL606 murein lipoprotein YP_003044846.1 1734688 D 413997 CDS YP_003044847.1 254161739 8178509 complement(1734988..1735992) 1 NC_012967.1 similar to b1678; hypothetical protein 1735992 ynhG 8178509 ynhG Escherichia coli B str. REL606 hypothetical protein YP_003044847.1 1734988 R 413997 CDS YP_003044848.1 254161740 8176274 complement(1736141..1736557) 1 NC_012967.1 Acts with SufS to catalyze the formation of L-alanine from L-cysteine; cysteine desufuration protein SufE 1736557 sufE 8176274 sufE Escherichia coli B str. REL606 cysteine desufuration protein SufE YP_003044848.1 1736141 R 413997 CDS YP_003044849.1 254161741 8176275 complement(1736570..1737790) 1 NC_012967.1 catalyzes the formation of L-alanine and selenide or sulfanylcysteine from selenocysteine or cysteine; bifunctional cysteine desulfurase/selenocysteine lyase 1737790 sufS 8176275 sufS Escherichia coli B str. REL606 bifunctional cysteine desulfurase/selenocysteine lyase YP_003044849.1 1736570 R 413997 CDS YP_003044850.1 254161742 8178510 complement(1737787..1739058) 1 NC_012967.1 with SufBC activates cysteine desulfurase SufS; cysteine desulfurase activator complex subunit SufD 1739058 sufD 8178510 sufD Escherichia coli B str. REL606 cysteine desulfurase activator complex subunit SufD YP_003044850.1 1737787 R 413997 CDS YP_003044851.1 254161743 8176276 complement(1739033..1739779) 1 NC_012967.1 part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE; cysteine desulfurase ATPase component 1739779 sufC 8176276 sufC Escherichia coli B str. REL606 cysteine desulfurase ATPase component YP_003044851.1 1739033 R 413997 CDS YP_003044852.1 254161744 8176277 complement(1739789..1741276) 1 NC_012967.1 with SufCD activates cysteine desulfurase SufS; cysteine desulfurase activator complex subunit SufB 1741276 sufB 8176277 sufB Escherichia coli B str. REL606 cysteine desulfurase activator complex subunit SufB YP_003044852.1 1739789 R 413997 CDS YP_003044853.1 254161745 8176278 complement(1741285..1741653) 1 NC_012967.1 functions as a scaffold on which iron-sulfur clusters ([2Fe-2S]; [4Fe-4S]) are assembled; forms a homodimer; similar to IscA protein; iron-sulfur cluster assembly scaffold protein 1741653 sufA 8176278 sufA Escherichia coli B str. REL606 iron-sulfur cluster assembly scaffold protein YP_003044853.1 1741285 R 413997 CDS YP_003044854.1 254161746 8176279 complement(1742201..1742470) 1 NC_012967.1 similar to b1685; hypothetical protein 1742470 ydiH 8176279 ydiH Escherichia coli B str. REL606 hypothetical protein YP_003044854.1 1742201 R 413997 CDS YP_003044855.1 254161747 8176280 complement(1742489..1742899) 1 NC_012967.1 similar to b1686; hypothetical protein 1742899 ydiI 8176280 ydiI Escherichia coli B str. REL606 hypothetical protein YP_003044855.1 1742489 R 413997 CDS YP_003044856.1 254161748 8176281 complement(1742896..1745952) 1 NC_012967.1 similar to b1687; putative FAD-linked oxidoreductase 1745952 ydiJ 8176281 ydiJ Escherichia coli B str. REL606 putative FAD-linked oxidoreductase YP_003044856.1 1742896 R 413997 CDS YP_003044857.1 254161749 8176282 1746341..1747453 1 NC_012967.1 YdiK; inner membrane protein; ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated; unknown function; putative inner membrane protein 1747453 ydiK 8176282 ydiK Escherichia coli B str. REL606 putative inner membrane protein YP_003044857.1 1746341 D 413997 CDS YP_003044858.1 254161750 8179058 1747882..1748238 1 NC_012967.1 similar to b1689; hypothetical protein 1748238 ydiL 8179058 ydiL Escherichia coli B str. REL606 hypothetical protein YP_003044858.1 1747882 D 413997 CDS YP_003044859.1 254161751 8176284 1749778..1751043 1 NC_012967.1 similar to b1691; putative transporter 1751043 ydiN 8176284 ydiN Escherichia coli B str. REL606 putative transporter YP_003044859.1 1749778 D 413997 CDS YP_003044860.1 254161752 8179059 1751055..1751921 1 NC_012967.1 YdiB; quinate/shikimate dehydrogenase from Escherichia coli uses both NAD and NAD(P) to convert quinate and shikimate to 3-dehydroquinate and 3-dehydroshikimate; quinate/shikimate dehydrogenase 1751921 ydiB 8179059 ydiB Escherichia coli B str. REL606 quinate/shikimate dehydrogenase YP_003044860.1 1751055 D 413997 CDS YP_003044861.1 254161753 8178511 1751952..1752710 1 NC_012967.1 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase 1752710 aroD 8178511 aroD Escherichia coli B str. REL606 3-dehydroquinate dehydratase YP_003044861.1 1751952 D 413997 CDS YP_003044862.1 254161754 8176285 1752855..1754450 1 NC_012967.1 similar to b1694; acetyl-CoA:acetoacetyl-CoA transferase subunit alpha/beta 1754450 ydiF 8176285 ydiF Escherichia coli B str. REL606 acetyl-CoA:acetoacetyl-CoA transferase subunit alpha/beta YP_003044862.1 1752855 D 413997 CDS YP_003044863.1 254161755 8176286 1754464..1755615 1 NC_012967.1 may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain; putative acyl-CoA dehydrogenase 1755615 ydiO 8176286 ydiO Escherichia coli B str. REL606 putative acyl-CoA dehydrogenase YP_003044863.1 1754464 D 413997 CDS YP_003044864.1 254161756 8176287 complement(1755658..1756569) 1 NC_012967.1 similar to b1696; putative DNA-binding transcriptional regulator 1756569 ydiP 8176287 ydiP Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003044864.1 1755658 R 413997 CDS YP_003044865.1 254161757 8176288 1756885..1757649 1 NC_012967.1 YdiO, YdiQ, YdiR, YdiS, and YdiT may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain; putative electron transfer flavoprotein YdiQ 1757649 ydiQ 8176288 ydiQ Escherichia coli B str. REL606 putative electron transfer flavoprotein YdiQ YP_003044865.1 1756885 D 413997 CDS YP_003044866.1 254161758 8176289 1757669..1758607 1 NC_012967.1 May play a role in a redox process; electron transfer flavoprotein subunit YdiR 1758607 ydiR 8176289 ydiR Escherichia coli B str. REL606 electron transfer flavoprotein subunit YdiR YP_003044866.1 1757669 D 413997 CDS YP_003044867.1 254161759 8176290 1758663..1759952 1 NC_012967.1 similar to b1699; hypothetical protein 1759952 ydiS 8176290 ydiS Escherichia coli B str. REL606 hypothetical protein YP_003044867.1 1758663 D 413997 CDS YP_003044868.1 254161760 8176291 1759949..1760242 1 NC_012967.1 similar to b1700; putative 4Fe-4S ferredoxin-type protein 1760242 ydiT 8176291 ydiT Escherichia coli B str. REL606 putative 4Fe-4S ferredoxin-type protein YP_003044868.1 1759949 D 413997 CDS YP_003044869.1 254161761 8179060 1760245..1761945 1 NC_012967.1 acts in anaerobic beta-oxidation of fatty acids; possible ligase/synthase involved in anaerobic growth on fatty acids; short chain acyl-CoA synthetase 1761945 ydiD 8179060 ydiD Escherichia coli B str. REL606 short chain acyl-CoA synthetase YP_003044869.1 1760245 D 413997 CDS YP_003044870.1 254161762 8176292 complement(1762002..1764380) 1 NC_012967.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; phosphoenolpyruvate synthase 1764380 ppsA 8176292 ppsA Escherichia coli B str. REL606 phosphoenolpyruvate synthase YP_003044870.1 1762002 R 413997 CDS YP_003044871.1 254161763 8176293 1764713..1765546 1 NC_012967.1 similar to b1703; hypothetical protein 1765546 ydiA 8176293 ydiA Escherichia coli B str. REL606 hypothetical protein YP_003044871.1 1764713 D 413997 CDS YP_003044872.1 254161764 8179061 1765703..1766749 1 NC_012967.1 tryptophan sensitive; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate; phospho-2-dehydro-3-deoxyheptonate aldolase 1766749 aroH 8179061 aroH Escherichia coli B str. REL606 phospho-2-dehydro-3-deoxyheptonate aldolase YP_003044872.1 1765703 D 413997 CDS YP_003044873.1 254161765 8176294 1766881..1767072 1 NC_012967.1 similar to b1705; hypothetical protein 1767072 ydiE 8176294 ydiE Escherichia coli B str. REL606 hypothetical protein YP_003044873.1 1766881 D 413997 CDS YP_003044874.1 254161766 8176295 complement(1767076..1768512) 1 NC_012967.1 similar to b1706; hypothetical protein 1768512 ydiU 8176295 ydiU Escherichia coli B str. REL606 hypothetical protein YP_003044874.1 1767076 R 413997 CDS YP_003044875.1 254161767 8179062 complement(1768575..1769117) 1 NC_012967.1 similar to b1707; hypothetical protein 1769117 ydiV 8179062 ydiV Escherichia coli B str. REL606 hypothetical protein YP_003044875.1 1768575 R 413997 CDS YP_003044876.1 254161768 8176296 complement(1769534..1769998) 1 NC_012967.1 similar to b1708; putative lipoprotein 1769998 nlpC 8176296 nlpC Escherichia coli B str. REL606 putative lipoprotein YP_003044876.1 1769534 R 413997 CDS YP_003044877.1 254161769 8178512 complement(1770076..1770825) 1 NC_012967.1 ATP-binding protein that acts with the transmembrane protein BtuC and the solute binding protein BtuF to transport vitamin B12 into the cell; vitamin B12-transporter ATPase 1770825 btuD 8178512 btuD Escherichia coli B str. REL606 vitamin B12-transporter ATPase YP_003044877.1 1770076 R 413997 CDS YP_003044878.1 254161770 8176297 complement(1770825..1771376) 1 NC_012967.1 similar to glutathione peroxidase; member of the btuCED operon which is required for vitamin B12 transport across the inner membrane; putative glutathione peroxidase 1771376 btuE 8176297 btuE Escherichia coli B str. REL606 putative glutathione peroxidase YP_003044878.1 1770825 R 413997 CDS YP_003044879.1 254161771 8176298 complement(1771439..1772419) 1 NC_012967.1 with BtuD and BtuF transports vitamin B12 into the cell; vtamin B12-transporter permease 1772419 btuC 8176298 btuC Escherichia coli B str. REL606 vtamin B12-transporter permease YP_003044879.1 1771439 R 413997 CDS YP_003044880.1 254161772 8178513 complement(1772520..1772819) 1 NC_012967.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit alpha 1772819 ihfA 8178513 ihfA Escherichia coli B str. REL606 integration host factor subunit alpha YP_003044880.1 1772520 R 413997 CDS YP_003044881.1 254161773 8176299 complement(1772824..1775211) 1 NC_012967.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 1775211 pheT 8176299 pheT Escherichia coli B str. REL606 phenylalanyl-tRNA synthetase subunit beta YP_003044881.1 1772824 R 413997 CDS YP_003044882.1 254161774 8176300 complement(1775226..1776209) 1 NC_012967.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 1776209 pheS 8176300 pheS Escherichia coli B str. REL606 phenylalanyl-tRNA synthetase subunit alpha YP_003044882.1 1775226 R 413997 CDS YP_003044884.1 254161776 8176302 complement(1776660..1777016) 1 NC_012967.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 1777016 rplT 8176302 rplT Escherichia coli B str. REL606 50S ribosomal protein L20 YP_003044884.1 1776660 R 413997 CDS YP_003044885.1 254161777 8176303 complement(1777069..1777266) 1 NC_012967.1 similar to b1717; 50S ribosomal protein L35 1777266 rpmI 8176303 rpmI Escherichia coli B str. REL606 50S ribosomal protein L35 YP_003044885.1 1777069 R 413997 CDS YP_003044886.1 254161778 8176304 complement(1777363..1777797) 1 NC_012967.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 1777797 infC 8176304 infC Escherichia coli B str. REL606 translation initiation factor IF-3 YP_003044886.1 1777363 R 413997 CDS YP_003044887.1 254161779 8176305 complement(1777909..1779837) 1 NC_012967.1 catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; threonyl-tRNA synthetase 1779837 thrS 8176305 thrS Escherichia coli B str. REL606 threonyl-tRNA synthetase YP_003044887.1 1777909 R 413997 CDS YP_003044888.1 254161780 8176306 1782415..1782537 1 NC_012967.1 similar to b4535; hypothetical protein 1782537 8176306 ECB_01690 Escherichia coli B str. REL606 hypothetical protein YP_003044888.1 1782415 D 413997 CDS YP_003044889.1 254161781 8176307 complement(1782590..1783348) 1 NC_012967.1 similar to b1722; hypothetical protein 1783348 ydiY 8176307 ydiY Escherichia coli B str. REL606 hypothetical protein YP_003044889.1 1782590 R 413997 CDS YP_003044890.1 254161782 8179064 1783635..1784564 1 NC_012967.1 similar to b1723; 6-phosphofructokinase 2 1784564 pfkB 8179064 pfkB Escherichia coli B str. REL606 6-phosphofructokinase 2 YP_003044890.1 1783635 D 413997 CDS YP_003044891.1 254161783 8176308 1784665..1784955 1 NC_012967.1 similar to b1724; hypothetical protein 1784955 ydiZ 8176308 ydiZ Escherichia coli B str. REL606 hypothetical protein YP_003044891.1 1784665 D 413997 CDS YP_003044892.1 254161784 8176309 1785061..1785921 1 NC_012967.1 similar to b1725; putative phosphotransferase/kinase 1785921 yniA 8176309 yniA Escherichia coli B str. REL606 putative phosphotransferase/kinase YP_003044892.1 1785061 D 413997 CDS YP_003044893.1 254161785 8176310 complement(1785962..1786498) 1 NC_012967.1 similar to b1726; putative inner membrane protein 1786498 yniB 8176310 yniB Escherichia coli B str. REL606 putative inner membrane protein YP_003044893.1 1785962 R 413997 CDS YP_003044894.1 254161786 8176311 1786645..1787313 1 NC_012967.1 YniC; catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate, mannose 6-phosphate and p-nitrophenyl phosphate; 2-deoxyglucose-6-phosphatase 1787313 yniC 8176311 yniC Escherichia coli B str. REL606 2-deoxyglucose-6-phosphatase YP_003044894.1 1786645 D 413997 CDS YP_003044895.1 254161787 8176312 1787476..1788066 1 NC_012967.1 similar to b1728; hypothetical protein 1788066 ydjM 8176312 ydjM Escherichia coli B str. REL606 hypothetical protein YP_003044895.1 1787476 D 413997 CDS YP_003044896.1 254161788 8179065 1788199..1789590 1 NC_012967.1 similar to b1729; putative transporter 1789590 ydjN 8179065 ydjN Escherichia coli B str. REL606 putative transporter YP_003044896.1 1788199 D 413997 CDS YP_003044897.1 254161789 8176313 complement(1789615..1790409) 1 NC_012967.1 similar to b1730; hypothetical protein 1790409 ydjO 8176313 ydjO Escherichia coli B str. REL606 hypothetical protein YP_003044897.1 1789615 R 413997 CDS YP_003044898.1 254161790 8176314 complement(1790686..1790949) 1 NC_012967.1 similar to b1731; cell division modulator 1790949 cedA 8176314 cedA Escherichia coli B str. REL606 cell division modulator YP_003044898.1 1790686 R 413997 CDS YP_003044899.1 254161791 8179066 1791132..1793393 1 NC_012967.1 Catalase HPII; monofunctional catalase that decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide; hydroperoxidase II 1793393 katE 8179066 katE Escherichia coli B str. REL606 hydroperoxidase II YP_003044899.1 1791132 D 413997 CDS YP_003044900.1 254161792 8176315 complement(1793651..1794400) 1 NC_012967.1 similar to b1733; hypothetical protein 1794400 ydjC 8176315 ydjC Escherichia coli B str. REL606 hypothetical protein YP_003044900.1 1793651 R 413997 CDS YP_003044901.1 254161793 8176316 complement(1794413..1795765) 1 NC_012967.1 similar to b1734; cryptic phospho-beta-glucosidase 1795765 celF 8176316 celF Escherichia coli B str. REL606 cryptic phospho-beta-glucosidase YP_003044901.1 1794413 R 413997 CDS YP_003044902.1 254161794 8179067 complement(1795870..1796712) 1 NC_012967.1 represses the celABCDF-ydjC operon involved in carbon uptake; DNA-binding transcriptional regulator ChbR 1796712 celD 8179067 celD Escherichia coli B str. REL606 DNA-binding transcriptional regulator ChbR YP_003044902.1 1795870 R 413997 CDS YP_003044903.1 254161795 8176317 complement(1796720..1797070) 1 NC_012967.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIA 1797070 celC 8176317 celC Escherichia coli B str. REL606 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIA YP_003044903.1 1796720 R 413997 CDS YP_003044904.1 254161796 8176318 complement(1797121..1798479) 1 NC_012967.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC 1798479 celB 8176318 celB Escherichia coli B str. REL606 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC YP_003044904.1 1797121 R 413997 CDS YP_003044905.1 254161797 8178514 complement(1798564..1798884) 1 NC_012967.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIB 1798884 celA 8178514 celA Escherichia coli B str. REL606 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIB YP_003044905.1 1798564 R 413997 CDS YP_003044906.1 254161798 8176319 complement(1799183..1799521) 1 NC_012967.1 osmotically-inducible lipoprotein E; activator of ntr-like gene protein; DNA-binding transcriptional activator OsmE 1799521 osmE 8176319 osmE Escherichia coli B str. REL606 DNA-binding transcriptional activator OsmE YP_003044906.1 1799183 R 413997 CDS YP_003044907.1 254161799 8176320 1799723..1800550 1 NC_012967.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase 1800550 nadE 8176320 nadE Escherichia coli B str. REL606 NAD synthetase YP_003044907.1 1799723 D 413997 CDS YP_003044908.1 254161800 8179068 1800780..1801667 1 NC_012967.1 3' incision activity; acts with UvrC; nucleotide excision repair endonuclease 1801667 ydjQ 8179068 ydjQ Escherichia coli B str. REL606 nucleotide excision repair endonuclease YP_003044908.1 1800780 D 413997 CDS YP_003044909.1 254161801 8176321 complement(1801627..1802202) 1 NC_012967.1 similar to b1742; hypothetical protein 1802202 ydjR 8176321 ydjR Escherichia coli B str. REL606 hypothetical protein YP_003044909.1 1801627 R 413997 CDS YP_003044910.1 254161802 8176322 complement(1802405..1802890) 1 NC_012967.1 periplasmic protein induced by stress response via Cpx and BaeSR system; similar to CpxP; periplasmic protein 1802890 spy 8176322 spy Escherichia coli B str. REL606 periplasmic protein YP_003044910.1 1802405 R 413997 CDS YP_003044911.1 254161803 8179069 complement(1803220..1804188) 1 NC_012967.1 catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism; succinylglutamate desuccinylase 1804188 astE 8179069 astE Escherichia coli B str. REL606 succinylglutamate desuccinylase YP_003044911.1 1803220 R 413997 CDS YP_003044912.1 254161804 8176323 complement(1804181..1805524) 1 NC_012967.1 catalyzes the hydrolysis of 2-N-succinylarginine into 2-N-succinylornithine, ammonia and carbon dioxide in arginine degradation; succinylarginine dihydrolase 1805524 astB 8176323 astB Escherichia coli B str. REL606 succinylarginine dihydrolase YP_003044912.1 1804181 R 413997 CDS YP_003044913.1 254161805 8176324 complement(1805521..1806999) 1 NC_012967.1 a high throughput screen identified this enzyme as an aldehyde dehydrogenase with broad substrate specificity; converts succinylglutamate semialdehyde and NAD to succinylglutamate and NADH; succinylglutamic semialdehyde dehydrogenase 1806999 astD 8176324 astD Escherichia coli B str. REL606 succinylglutamic semialdehyde dehydrogenase YP_003044913.1 1805521 R 413997 CDS YP_003044914.1 254161806 8179070 complement(1806996..1808030) 1 NC_012967.1 similar to b1747; arginine succinyltransferase 1808030 astA 8179070 astA Escherichia coli B str. REL606 arginine succinyltransferase YP_003044914.1 1806996 R 413997 CDS YP_003044915.1 254161807 8176325 complement(1808027..1809247) 1 NC_012967.1 catalyzes the transamination of 2-N-succinylornithine and alpha-ketoglutarate into 2-N-succinylglutamate semialdehyde and glutamate; also functions as the catabolic acetylornithine aminotransferase catalyzing the formation of 2-N-acetylglutamate semialdehyde and glutamate from 2-N-acetylornithine and alpha-ketoglutarate; bifunctional succinylornithine transaminase/acetylornithine transaminase 1809247 astC 8176325 astC Escherichia coli B str. REL606 bifunctional succinylornithine transaminase/acetylornithine transaminase YP_003044915.1 1808027 R 413997 CDS YP_003044916.1 254161808 8176326 1809693..1810499 1 NC_012967.1 removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction; exonuclease III 1810499 xthA 8176326 xthA Escherichia coli B str. REL606 exonuclease III YP_003044916.1 1809693 D 413997 CDS YP_003044917.1 254161809 8178515 1810666..1811376 1 NC_012967.1 similar to b1750; putative inner membrane protein 1811376 ydjX 8178515 ydjX Escherichia coli B str. REL606 putative inner membrane protein YP_003044917.1 1810666 D 413997 CDS YP_003044918.1 254161810 8176328 1812036..1812743 1 NC_012967.1 similar to b1752; inner membrane protein 1812743 ydjZ 8176328 ydjZ Escherichia coli B str. REL606 inner membrane protein YP_003044918.1 1812036 D 413997 CDS YP_003044919.1 254161811 8178516 1812743..1813291 1 NC_012967.1 similar to b1753; hypothetical protein 1813291 ynjA 8178516 ynjA Escherichia coli B str. REL606 hypothetical protein YP_003044919.1 1812743 D 413997 CDS YP_003044920.1 254161812 8176329 1813301..1814467 1 NC_012967.1 similar to b1754; putative ABC transporter solute-binding protein 1814467 ynjB 8176329 ynjB Escherichia coli B str. REL606 putative ABC transporter solute-binding protein YP_003044920.1 1813301 D 413997 CDS YP_003044921.1 254161813 8179071 1814485..1815975 1 NC_012967.1 similar to b1755; ABC transporter membrane protein 1815975 ynjC 8179071 ynjC Escherichia coli B str. REL606 ABC transporter membrane protein YP_003044921.1 1814485 D 413997 CDS YP_003044922.1 254161814 8176330 1815975..1816628 1 NC_012967.1 similar to b1756; putative transporter subunit ATP-binding protein of ABC superfamily 1816628 ynjD 8176330 ynjD Escherichia coli B str. REL606 putative transporter subunit ATP-binding protein of ABC superfamily YP_003044922.1 1815975 D 413997 CDS YP_003044923.1 254161815 8178517 1816695..1818002 1 NC_012967.1 similar to b1757; putative thiosulfate sulfur transferase 1818002 ynjE 8178517 ynjE Escherichia coli B str. REL606 putative thiosulfate sulfur transferase YP_003044923.1 1816695 D 413997 CDS YP_003044924.1 254161816 8176331 complement(1818011..1818631) 1 NC_012967.1 similar to b1758; putative phosphatidyl transferase, inner membrane protein 1818631 ynjF 8176331 ynjF Escherichia coli B str. REL606 putative phosphatidyl transferase, inner membrane protein YP_003044924.1 1818011 R 413997 CDS YP_003044925.1 254161817 8176332 1818718..1819125 1 NC_012967.1 similar to b1759; pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase 1819125 nudG 8176332 nudG Escherichia coli B str. REL606 pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase YP_003044925.1 1818718 D 413997 CDS YP_003044926.1 254161818 8178518 complement(1819091..1819363) 1 NC_012967.1 similar to b1760; hypothetical protein 1819363 ynjH 8178518 ynjH Escherichia coli B str. REL606 hypothetical protein YP_003044926.1 1819091 R 413997 CDS YP_003044927.1 254161819 8178519 1819599..1820942 1 NC_012967.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 1820942 gdhA 8178519 gdhA Escherichia coli B str. REL606 glutamate dehydrogenase YP_003044927.1 1819599 D 413997 CDS YP_003044928.1 254161820 8176333 complement(1821059..1822099) 1 NC_012967.1 similar to b1762; hypothetical protein 1822099 ynjI 8176333 ynjI Escherichia coli B str. REL606 hypothetical protein YP_003044928.1 1821059 R 413997 CDS YP_003044929.1 254161821 8176334 complement(1822227..1824188) 1 NC_012967.1 decatenates replicating daughter chromosomes; DNA topoisomerase III 1824188 topB 8176334 topB Escherichia coli B str. REL606 DNA topoisomerase III YP_003044929.1 1822227 R 413997 CDS YP_003044930.1 254161822 8178520 complement(1824193..1825236) 1 NC_012967.1 catalyzes the formation of selenophosphate from selenide and ATP; selenophosphate synthetase 1825236 selD 8178520 selD Escherichia coli B str. REL606 selenophosphate synthetase YP_003044930.1 1824193 R 413997 CDS YP_003044931.1 254161823 8176335 complement(1825353..1825904) 1 NC_012967.1 similar to b1765; hypothetical protein 1825904 ydjA 8176335 ydjA Escherichia coli B str. REL606 hypothetical protein YP_003044931.1 1825353 R 413997 CDS YP_003044932.1 254161824 8179072 1826065..1827921 1 NC_012967.1 SppA; catalyzes the degradation of cleaved signal peptides; essential to maintain secretion of mature proteins across the membrane; protease 4 1827921 sppA 8179072 sppA Escherichia coli B str. REL606 protease 4 YP_003044932.1 1826065 D 413997 CDS YP_003044933.1 254161825 8176336 1828088..1829104 1 NC_012967.1 converts asparagine to aspartate and ammonia; cytoplasmic asparaginase I 1829104 ansA 8176336 ansA Escherichia coli B str. REL606 cytoplasmic asparaginase I YP_003044933.1 1828088 D 413997 CDS YP_003044934.1 254161826 8176337 1829115..1829756 1 NC_012967.1 catalyzes the formation of nicotinate from nicotinamide in NAD biosynthesis and the formation of pyrazinoate from pyrazinamide; nicotinamidase/pyrazinamidase 1829756 pncA 8176337 pncA Escherichia coli B str. REL606 nicotinamidase/pyrazinamidase YP_003044934.1 1829115 D 413997 CDS YP_003044935.1 254161827 8176338 complement(1829849..1831207) 1 NC_012967.1 similar to b1769; putative transporter 1831207 ydjE 8176338 ydjE Escherichia coli B str. REL606 putative transporter YP_003044935.1 1829849 R 413997 CDS YP_003044936.1 254161828 8176339 complement(1831325..1832083) 1 NC_012967.1 similar to b1770; putative DNA-binding transcriptional regulator 1832083 ydjF 8176339 ydjF Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003044936.1 1831325 R 413997 CDS YP_003044937.1 254161829 8176340 complement(1832220..1833200) 1 NC_012967.1 similar to b1771; putative oxidoreductase 1833200 ydjG 8176340 ydjG Escherichia coli B str. REL606 putative oxidoreductase YP_003044937.1 1832220 R 413997 CDS YP_003044938.1 254161830 8176341 complement(1833210..1834157) 1 NC_012967.1 similar to b1772; putative kinase 1834157 ydjH 8176341 ydjH Escherichia coli B str. REL606 putative kinase YP_003044938.1 1833210 R 413997 CDS YP_003044939.1 254161831 8176342 complement(1834162..1834998) 1 NC_012967.1 similar to b1773; putative aldolase 1834998 ydjI 8176342 ydjI Escherichia coli B str. REL606 putative aldolase YP_003044939.1 1834162 R 413997 CDS YP_003044940.1 254161832 8176343 complement(1835019..1836062) 1 NC_012967.1 similar to b1774; putative oxidoreductase, Zn-dependent and NAD(P)-binding 1836062 ydjJ 8176343 ydjJ Escherichia coli B str. REL606 putative oxidoreductase, Zn-dependent and NAD(P)-binding YP_003044940.1 1835019 R 413997 CDS YP_003044941.1 254161833 8178521 complement(1836079..1837458) 1 NC_012967.1 similar to b1775; putative transporter 1837458 ydjK 8178521 ydjK Escherichia coli B str. REL606 putative transporter YP_003044941.1 1836079 R 413997 CDS YP_003044942.1 254161834 8176344 complement(1837485..1838561) 1 NC_012967.1 similar to b1776; putative oxidoreductase, Zn-dependent and NAD(P)-binding 1838561 ydjL 8176344 ydjL Escherichia coli B str. REL606 putative oxidoreductase, Zn-dependent and NAD(P)-binding YP_003044942.1 1837485 R 413997 CDS YP_003044943.1 254161835 8178522 complement(1838931..1839203) 1 NC_012967.1 similar to b1777; hypothetical protein 1839203 yeaC 8178522 yeaC Escherichia coli B str. REL606 hypothetical protein YP_003044943.1 1838931 R 413997 CDS YP_003044944.1 254161836 8176345 complement(1839245..1839658) 1 NC_012967.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress; methionine sulfoxide reductase B 1839658 yeaA 8176345 yeaA Escherichia coli B str. REL606 methionine sulfoxide reductase B YP_003044944.1 1839245 R 413997 CDS YP_003044945.1 254161837 8176346 1840000..1840995 1 NC_012967.1 similar to b1779; glyceraldehyde-3-phosphate dehydrogenase 1840995 gapA 8176346 gapA Escherichia coli B str. REL606 glyceraldehyde-3-phosphate dehydrogenase YP_003044945.1 1840000 D 413997 CDS YP_003044946.1 254161838 8178523 1841079..1841963 1 NC_012967.1 similar to b1780; hypothetical protein 1841963 yeaD 8178523 yeaD Escherichia coli B str. REL606 hypothetical protein YP_003044946.1 1841079 D 413997 CDS YP_003044947.1 254161839 8176347 complement(1842011..1842865) 1 NC_012967.1 similar to b1781; putative oxidoreductase 1842865 yeaE 8176347 yeaE Escherichia coli B str. REL606 putative oxidoreductase YP_003044947.1 1842011 R 413997 CDS YP_003044948.1 254161840 8178524 complement(1842955..1843701) 1 NC_012967.1 similar to b1782; scaffolding protein for murein synthesizing machinery 1843701 mipA 8178524 mipA Escherichia coli B str. REL606 scaffolding protein for murein synthesizing machinery YP_003044948.1 1842955 R 413997 CDS YP_003044949.1 254161841 8176348 1844263..1846071 1 NC_012967.1 similar to b1783; hypothetical protein 1846071 yeaG 8176348 yeaG Escherichia coli B str. REL606 hypothetical protein YP_003044949.1 1844263 D 413997 CDS YP_003044950.1 254161842 8176349 1846184..1847467 1 NC_012967.1 similar to b1784; hypothetical protein 1847467 yeaH 8176349 yeaH Escherichia coli B str. REL606 hypothetical protein YP_003044950.1 1846184 D 413997 CDS YP_003044951.1 254161843 8176350 1847614..1849089 1 NC_012967.1 similar to b1785; putative diguanylate cyclase 1849089 yeaI 8176350 yeaI Escherichia coli B str. REL606 putative diguanylate cyclase YP_003044951.1 1847614 D 413997 CDS YP_003044952.1 254161844 8176351 1849270..1850760 1 NC_012967.1 similar to b1786; putative diguanylate cyclase 1850760 yeaJ 8176351 yeaJ Escherichia coli B str. REL606 putative diguanylate cyclase YP_003044952.1 1849270 D 413997 CDS YP_003044953.1 254161845 8176352 1850803..1851306 1 NC_012967.1 similar to b1787; hypothetical protein 1851306 yeaK 8176352 yeaK Escherichia coli B str. REL606 hypothetical protein YP_003044953.1 1850803 D 413997 CDS YP_003044954.1 254161846 8179073 complement(1851307..1851411) 1 NC_012967.1 similar to b1788; hypothetical protein 1851411 8179073 ECB_01757 Escherichia coli B str. REL606 hypothetical protein YP_003044954.1 1851307 R 413997 CDS YP_003044955.1 254161847 8176353 1851581..1852027 1 NC_012967.1 similar to b1789; inner membrane protein 1852027 yeaL 8176353 yeaL Escherichia coli B str. REL606 inner membrane protein YP_003044955.1 1851581 D 413997 CDS YP_003044956.1 254161848 8176354 complement(1851984..1852805) 1 NC_012967.1 similar to b1790; putative DNA-binding transcriptional regulator 1852805 yeaM 8176354 yeaM Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003044956.1 1851984 R 413997 CDS YP_003044957.1 254161849 8176355 1852902..1854083 1 NC_012967.1 similar to b1791; putative transporter 1854083 yeaN 8176355 yeaN Escherichia coli B str. REL606 putative transporter YP_003044957.1 1852902 D 413997 CDS YP_003044958.1 254161850 8176356 1854138..1854485 1 NC_012967.1 similar to b1792; hypothetical protein 1854485 yeaO 8176356 yeaO Escherichia coli B str. REL606 hypothetical protein YP_003044958.1 1854138 D 413997 CDS YP_003044959.1 254161851 8176357 complement(1854507..1854761) 1 NC_012967.1 similar to b1793; outer membrane protein 1854761 yoaF 8176357 yoaF Escherichia coli B str. REL606 outer membrane protein YP_003044959.1 1854507 R 413997 CDS YP_003044960.1 254161852 8176358 1854944..1855969 1 NC_012967.1 similar to b1794; putative diguanylate cyclase 1855969 yeaP 8176358 yeaP Escherichia coli B str. REL606 putative diguanylate cyclase YP_003044960.1 1854944 D 413997 CDS YP_003044961.1 254161853 8176359 complement(1856236..1856484) 1 NC_012967.1 similar to b1795; hypothetical protein 1856484 yeaQ 8176359 yeaQ Escherichia coli B str. REL606 hypothetical protein YP_003044961.1 1856236 R 413997 CDS YP_003044962.1 254161854 8176360 complement(1856632..1856814) 1 NC_012967.1 similar to b1796; hypothetical protein 1856814 yoaG 8176360 yoaG Escherichia coli B str. REL606 hypothetical protein YP_003044962.1 1856632 R 413997 CDS YP_003044963.1 254161855 8178525 complement(1856818..1857042) 1 NC_012967.1 similar to b1797; hypothetical protein 1857042 yeaR 8178525 yeaR Escherichia coli B str. REL606 hypothetical protein YP_003044963.1 1856818 R 413997 CDS YP_003044964.1 254161856 8176361 1857121..1858233 1 NC_012967.1 putative transposase insL for insertion sequence IS186 1858233 insL-4 8176361 insL-4 Escherichia coli B str. REL606 putative transposase insL for insertion sequence IS186 YP_003044964.1 1857121 D 413997 CDS YP_003044965.1 254161857 8176362 complement(1858699..1859337) 1 NC_012967.1 similar to b1798; leucine export protein LeuE 1859337 yeaS 8176362 yeaS Escherichia coli B str. REL606 leucine export protein LeuE YP_003044965.1 1858699 R 413997 CDS YP_003044966.1 254161858 8176363 complement(1859464..1860387) 1 NC_012967.1 similar to b1799; putative DNA-binding transcriptional regulator 1860387 yeaT 8176363 yeaT Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003044966.1 1859464 R 413997 CDS YP_003044967.1 254161859 8176364 1860490..1861575 1 NC_012967.1 similar to b1800; putative dehydrogenase 1861575 yeaU 8176364 yeaU Escherichia coli B str. REL606 putative dehydrogenase YP_003044967.1 1860490 D 413997 CDS YP_003044968.1 254161860 8176365 1861766..1863211 1 NC_012967.1 member of the betaine, carnitine, choline transporter (BCCT) family; unknown function; putative transporter 1863211 yeaV 8176365 yeaV Escherichia coli B str. REL606 putative transporter YP_003044968.1 1861766 D 413997 CDS YP_003044969.1 254161861 8179074 1863243..1864367 1 NC_012967.1 similar to b1802; putative 2Fe-2S cluster-containing protein 1864367 yeaW 8179074 yeaW Escherichia coli B str. REL606 putative 2Fe-2S cluster-containing protein YP_003044969.1 1863243 D 413997 CDS YP_003044970.1 254161862 8176366 1864423..1865388 1 NC_012967.1 similar to b1803; putative oxidoreductase 1865388 yeaX 8176366 yeaX Escherichia coli B str. REL606 putative oxidoreductase YP_003044970.1 1864423 D 413997 CDS YP_003044971.1 254161863 8179075 complement(1865442..1866569) 1 NC_012967.1 similar to b1804; ribonuclease D 1866569 rnd 8179075 rnd Escherichia coli B str. REL606 ribonuclease D YP_003044971.1 1865442 R 413997 CDS YP_003044972.1 254161864 8176367 complement(1866639..1868324) 1 NC_012967.1 Activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 1868324 fadD 8176367 fadD Escherichia coli B str. REL606 long-chain-fatty-acid--CoA ligase YP_003044972.1 1866639 R 413997 CDS YP_003044973.1 254161865 8176368 complement(1868529..1869110) 1 NC_012967.1 similar to b1806; putative lipoprotein 1869110 yeaY 8176368 yeaY Escherichia coli B str. REL606 putative lipoprotein YP_003044973.1 1868529 R 413997 CDS YP_003044974.1 254161866 8179076 complement(1869150..1869845) 1 NC_012967.1 similar to b1807; putative peptidase 1869845 yeaZ 8179076 yeaZ Escherichia coli B str. REL606 putative peptidase YP_003044974.1 1869150 R 413997 CDS YP_003044975.1 254161867 8176369 complement(1869903..1871813) 1 NC_012967.1 similar to b1808; hypothetical protein 1871813 yoaA 8176369 yoaA Escherichia coli B str. REL606 hypothetical protein YP_003044975.1 1869903 R 413997 CDS YP_003044976.1 254161868 8176370 1871945..1872289 1 NC_012967.1 similar to b1809; hypothetical protein 1872289 yoaB 8176370 yoaB Escherichia coli B str. REL606 hypothetical protein YP_003044976.1 1871945 D 413997 CDS YP_003044977.1 254161869 8179077 1872652..1873011 1 NC_012967.1 similar to b1810; hypothetical protein 1873011 yoaC 8179077 yoaC Escherichia coli B str. REL606 hypothetical protein YP_003044977.1 1872652 D 413997 CDS YP_003044978.1 254161870 8176371 complement(1873131..1873310) 1 NC_012967.1 similar to b1811; hypothetical protein 1873310 yoaH 8176371 yoaH Escherichia coli B str. REL606 hypothetical protein YP_003044978.1 1873131 R 413997 CDS YP_003044979.1 254161871 8176372 1873384..1874745 1 NC_012967.1 similar to b1812; para-aminobenzoate synthase component I 1874745 pabB 8176372 pabB Escherichia coli B str. REL606 para-aminobenzoate synthase component I YP_003044979.1 1873384 D 413997 CDS YP_003044980.1 254161872 8176373 1874749..1875327 1 NC_012967.1 similar to b1813; hypothetical protein 1875327 yeaB 8176373 yeaB Escherichia coli B str. REL606 hypothetical protein YP_003044980.1 1874749 D 413997 CDS YP_003044981.1 254161873 8176374 1875511..1876875 1 NC_012967.1 similar to b1814; L-serine deaminase I 1876875 sdaA 8176374 sdaA Escherichia coli B str. REL606 L-serine deaminase I YP_003044981.1 1875511 D 413997 CDS YP_003044982.1 254161874 8179078 1877006..1878604 1 NC_012967.1 similar to b1815; putative phosphodiesterase 1878604 yoaD 8179078 yoaD Escherichia coli B str. REL606 putative phosphodiesterase YP_003044982.1 1877006 D 413997 CDS YP_003044983.1 254161875 8178526 complement(1878608..1880164) 1 NC_012967.1 similar to b1816; hypothetical protein 1880164 yoaE 8178526 yoaE Escherichia coli B str. REL606 hypothetical protein YP_003044983.1 1878608 R 413997 CDS YP_003044984.1 254161876 8176375 1880627..1881598 1 NC_012967.1 similar to b1817; PTS system mannose-specific transporter subunit IIAB 1881598 manX 8176375 manX Escherichia coli B str. REL606 PTS system mannose-specific transporter subunit IIAB YP_003044984.1 1880627 D 413997 CDS YP_003044985.1 254161877 8176376 1881661..1882461 1 NC_012967.1 similar to b1818; mannose-specific PTS system transporter subunit IIC 1882461 manY 8176376 manY Escherichia coli B str. REL606 mannose-specific PTS system transporter subunit IIC YP_003044985.1 1881661 D 413997 CDS YP_003044986.1 254161878 8178527 1882465..1883325 1 NC_012967.1 hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel; PTS system mannose-specific transporter subunit IID 1883325 manZ 8178527 manZ Escherichia coli B str. REL606 PTS system mannose-specific transporter subunit IID YP_003044986.1 1882465 D 413997 CDS YP_003044987.1 254161879 8176377 1883380..1883838 1 NC_012967.1 similar to b1820; hypothetical protein 1883838 yobD 8176377 yobD Escherichia coli B str. REL606 hypothetical protein YP_003044987.1 1883380 D 413997 CDS YP_003044988.1 254161880 8178528 1884267..1884833 1 NC_012967.1 membrane protein YebN; hypothetical protein 1884833 yebN 8178528 yebN Escherichia coli B str. REL606 hypothetical protein YP_003044988.1 1884267 D 413997 CDS YP_003044989.1 254161881 8176378 complement(1884830..1885639) 1 NC_012967.1 methylates the guanosine in position 745 of 23S rRNA; required for translation and cell growth; 23S rRNA methyltransferase A 1885639 rrmA 8176378 rrmA Escherichia coli B str. REL606 23S rRNA methyltransferase A YP_003044989.1 1884830 R 413997 CDS YP_003044990.1 254161882 8176379 complement(1885805..1886014) 1 NC_012967.1 similar to b1823; cold shock-like protein CspC 1886014 cspC 8176379 cspC Escherichia coli B str. REL606 cold shock-like protein CspC YP_003044990.1 1885805 R 413997 CDS YP_003044991.1 254161883 8176380 complement(1886027..1886170) 1 NC_012967.1 similar to b1824; hypothetical protein 1886170 yobF 8176380 yobF Escherichia coli B str. REL606 hypothetical protein YP_003044991.1 1886027 R 413997 CDS YP_003044992.1 254161884 8178529 complement(1886839..1887126) 1 NC_012967.1 similar to b1825; hypothetical protein 1887126 yebO 8178529 yebO Escherichia coli B str. REL606 hypothetical protein YP_003044992.1 1886839 R 413997 CDS YP_003044993.1 254161885 8176381 complement(1887201..1887344) 1 NC_012967.1 similar to b1826; hypothetical protein 1887344 yobG 8176381 yobG Escherichia coli B str. REL606 hypothetical protein YP_003044993.1 1887201 R 413997 CDS YP_003044994.1 254161886 8176382 1887503..1887742 1 NC_012967.1 similar to b4536; hypothetical protein 1887742 8176382 ECB_01797 Escherichia coli B str. REL606 hypothetical protein YP_003044994.1 1887503 D 413997 CDS YP_003044995.1 254161887 8176383 complement(1887885..1888676) 1 NC_012967.1 similar to b1827; putative DNA-binding transcriptional regulator 1888676 kdgR 8176383 kdgR Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003044995.1 1887885 R 413997 CDS YP_003044996.1 254161888 8176384 1888853..1890226 1 NC_012967.1 similar to b1828; putative transporter 1890226 yebQ 8176384 yebQ Escherichia coli B str. REL606 putative transporter YP_003044996.1 1888853 D 413997 CDS YP_003044997.1 254161889 8179079 complement(1890272..1891153) 1 NC_012967.1 putative metalloprotease; heat shock protein HtpX 1891153 htpX 8179079 htpX Escherichia coli B str. REL606 heat shock protein HtpX YP_003044997.1 1890272 R 413997 CDS YP_003044998.1 254161890 8176385 complement(1891345..1893393) 1 NC_012967.1 Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3; carboxy-terminal protease 1893393 prc 8176385 prc Escherichia coli B str. REL606 carboxy-terminal protease YP_003044998.1 1891345 R 413997 CDS YP_003044999.1 254161891 8176386 complement(1893413..1894111) 1 NC_012967.1 affects solute and DNA transport through an unknown mechanism; putative solute/DNA competence effector 1894111 proQ 8176386 proQ Escherichia coli B str. REL606 putative solute/DNA competence effector YP_003044999.1 1893413 R 413997 CDS YP_003045000.1 254161892 8176387 complement(1894208..1894759) 1 NC_012967.1 similar to b1832; hypothetical protein 1894759 yebR 8176387 yebR Escherichia coli B str. REL606 hypothetical protein YP_003045000.1 1894208 R 413997 CDS YP_003045001.1 254161893 8176388 1894835..1896118 1 NC_012967.1 similar to b1833; inner membrane protein 1896118 yebS 8176388 yebS Escherichia coli B str. REL606 inner membrane protein YP_003045001.1 1894835 D 413997 CDS YP_003045002.1 254161894 8176389 1896087..1898720 1 NC_012967.1 similar to b1834; hypothetical protein 1898720 yebT 8176389 yebT Escherichia coli B str. REL606 hypothetical protein YP_003045002.1 1896087 D 413997 CDS YP_003045003.1 254161895 8176390 1898800..1900239 1 NC_012967.1 in Escherichia coli this enzyme specifically methylates C1407 of the 16S rRNA; rRNA (cytosine-C(5)-)-methyltransferase RsmF 1900239 yebU 8176390 yebU Escherichia coli B str. REL606 rRNA (cytosine-C(5)-)-methyltransferase RsmF YP_003045003.1 1898800 D 413997 CDS YP_003045004.1 254161896 8179080 1900357..1900593 1 NC_012967.1 similar to b1836; hypothetical protein 1900593 yebV 8179080 yebV Escherichia coli B str. REL606 hypothetical protein YP_003045004.1 1900357 D 413997 CDS YP_003045005.1 254161897 8179081 1900698..1900889 1 NC_012967.1 similar to b1837; hypothetical protein 1900889 yebW 8179081 yebW Escherichia coli B str. REL606 hypothetical protein YP_003045005.1 1900698 D 413997 CDS YP_003045006.1 254161898 8176391 complement(1900890..1901546) 1 NC_012967.1 Plays a key role in signaling protein misfolding via the cpxR/cpxA transducing system; modulates the phosphorylated status of many phosphoproteins; serine/threonine protein phosphatase 1 1901546 pphA 8176391 pphA Escherichia coli B str. REL606 serine/threonine protein phosphatase 1 YP_003045006.1 1900890 R 413997 CDS YP_003045007.1 254161899 8178530 complement(1901941..1902282) 1 NC_012967.1 similar to b1839; hypothetical protein 1902282 yebY 8178530 yebY Escherichia coli B str. REL606 hypothetical protein YP_003045007.1 1901941 R 413997 CDS YP_003045008.1 254161900 8176392 complement(1902295..1903167) 1 NC_012967.1 similar to b1840; putative inner membrane protein 1903167 yebZ 8176392 yebZ Escherichia coli B str. REL606 putative inner membrane protein YP_003045008.1 1902295 R 413997 CDS YP_003045009.1 254161901 8176393 complement(1903171..1903545) 1 NC_012967.1 similar to b1841; hypothetical protein 1903545 yobA 8176393 yobA Escherichia coli B str. REL606 hypothetical protein YP_003045009.1 1903171 R 413997 CDS YP_003045010.1 254161902 8176394 1903684..1903914 1 NC_012967.1 similar to b1842; DNA polymerase III subunit theta 1903914 holE 8176394 holE Escherichia coli B str. REL606 DNA polymerase III subunit theta YP_003045010.1 1903684 D 413997 CDS YP_003045011.1 254161903 8176395 1904016..1904672 1 NC_012967.1 similar to b1843; hypothetical protein 1904672 yobB 8176395 yobB Escherichia coli B str. REL606 hypothetical protein YP_003045011.1 1904016 D 413997 CDS YP_003045012.1 254161904 8176396 1904696..1905358 1 NC_012967.1 3'-5' exonuclease activity on single or double-strand DNA; exodeoxyribonuclease X 1905358 exoX 8176396 exoX Escherichia coli B str. REL606 exodeoxyribonuclease X YP_003045012.1 1904696 D 413997 CDS YP_003045013.1 254161905 8176397 complement(1905355..1907415) 1 NC_012967.1 PtrB; oligopeptidase that cleaves peptide bonds following arginine and lysine residues; protease 2 1907415 ptrB 8176397 ptrB Escherichia coli B str. REL606 protease 2 YP_003045013.1 1905355 R 413997 CDS YP_003045014.1 254161906 8178531 complement(1907624..1908283) 1 NC_012967.1 similar to b1846; hypothetical protein 1908283 yebE 8178531 yebE Escherichia coli B str. REL606 hypothetical protein YP_003045014.1 1907624 R 413997 CDS YP_003045015.1 254161907 8176398 complement(1908610..1908978) 1 NC_012967.1 secreted protein; unknown function; hypothetical protein 1908978 yebF 8176398 yebF Escherichia coli B str. REL606 hypothetical protein YP_003045015.1 1908610 R 413997 CDS YP_003045016.1 254161908 8176399 complement(1909033..1909323) 1 NC_012967.1 similar to b1848; DNA damage-inducible protein YebG 1909323 yebG 8176399 yebG Escherichia coli B str. REL606 DNA damage-inducible protein YebG YP_003045016.1 1909033 R 413997 CDS YP_003045017.1 254161909 8176400 1909457..1910635 1 NC_012967.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis; phosphoribosylglycinamide formyltransferase 2 1910635 purT 8176400 purT Escherichia coli B str. REL606 phosphoribosylglycinamide formyltransferase 2 YP_003045017.1 1909457 D 413997 CDS YP_003045018.1 254161910 8179082 complement(1910691..1911332) 1 NC_012967.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase 1911332 eda 8179082 eda Escherichia coli B str. REL606 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase YP_003045018.1 1910691 R 413997 CDS YP_003045019.1 254161911 8176401 complement(1911369..1913180) 1 NC_012967.1 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate; phosphogluconate dehydratase 1913180 edd 8176401 edd Escherichia coli B str. REL606 phosphogluconate dehydratase YP_003045019.1 1911369 R 413997 CDS YP_003045020.1 254161912 8178532 complement(1913415..1914890) 1 NC_012967.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 1914890 zwf 8178532 zwf Escherichia coli B str. REL606 glucose-6-phosphate 1-dehydrogenase YP_003045020.1 1913415 R 413997 CDS YP_003045021.1 254161913 8179083 1915228..1916097 1 NC_012967.1 Represses the expression of the zwf, eda, glp and gap; DNA-binding transcriptional regulator HexR 1916097 yebK 8179083 yebK Escherichia coli B str. REL606 DNA-binding transcriptional regulator HexR YP_003045021.1 1915228 D 413997 CDS YP_003045022.1 254161914 8176402 1916225..1917667 1 NC_012967.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1917667 pykA 8176402 pykA Escherichia coli B str. REL606 pyruvate kinase YP_003045022.1 1916225 D 413997 CDS YP_003045023.1 254161915 8178533 complement(1917798..1918769) 1 NC_012967.1 Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase 1918769 msbB 8178533 msbB Escherichia coli B str. REL606 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase YP_003045023.1 1917798 R 413997 CDS YP_003045024.1 254161916 8176403 complement(1918889..1920148) 1 NC_012967.1 similar to b1856; hypothetical protein 1920148 yebA 8176403 yebA Escherichia coli B str. REL606 hypothetical protein YP_003045024.1 1918889 R 413997 CDS YP_003045025.1 254161917 8176404 complement(1920227..1921159) 1 NC_012967.1 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter periplasmic component 1921159 znuA 8176404 znuA Escherichia coli B str. REL606 high-affinity zinc transporter periplasmic component YP_003045025.1 1920227 R 413997 CDS YP_003045026.1 254161918 8176405 1921238..1921993 1 NC_012967.1 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter ATPase 1921993 znuC 8176405 znuC Escherichia coli B str. REL606 high-affinity zinc transporter ATPase YP_003045026.1 1921238 D 413997 CDS YP_003045027.1 254161919 8176406 1921990..1922775 1 NC_012967.1 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter membrane component 1922775 znuB 8176406 znuB Escherichia coli B str. REL606 high-affinity zinc transporter membrane component YP_003045027.1 1921990 D 413997 CDS YP_003045028.1 254161920 8176407 complement(1923116..1924126) 1 NC_012967.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 1924126 ruvB 8176407 ruvB Escherichia coli B str. REL606 Holliday junction DNA helicase RuvB YP_003045028.1 1923116 R 413997 CDS YP_003045029.1 254161921 8176408 complement(1924135..1924746) 1 NC_012967.1 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 1924746 ruvA 8176408 ruvA Escherichia coli B str. REL606 Holliday junction DNA helicase RuvA YP_003045029.1 1924135 R 413997 CDS YP_003045030.1 254161922 8178534 1925021..1925623 1 NC_012967.1 similar to b1862; hypothetical protein 1925623 yebB 8178534 yebB Escherichia coli B str. REL606 hypothetical protein YP_003045030.1 1925021 D 413997 CDS YP_003045031.1 254161923 8176409 complement(1925625..1926146) 1 NC_012967.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 1926146 ruvC 8176409 ruvC Escherichia coli B str. REL606 Holliday junction resolvase YP_003045031.1 1925625 R 413997 CDS YP_003045032.1 254161924 8178535 complement(1926181..1926921) 1 NC_012967.1 similar to b1864; hypothetical protein 1926921 yebC 8178535 yebC Escherichia coli B str. REL606 hypothetical protein YP_003045032.1 1926181 R 413997 CDS YP_003045033.1 254161925 8179084 complement(1926950..1927402) 1 NC_012967.1 converts dATP to dAMP and pyrophosphate; dATP pyrophosphohydrolase 1927402 ntpA 8179084 ntpA Escherichia coli B str. REL606 dATP pyrophosphohydrolase YP_003045033.1 1926950 R 413997 CDS YP_003045034.1 254161926 8176410 complement(1927520..1929292) 1 NC_012967.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 1929292 aspS 8176410 aspS Escherichia coli B str. REL606 aspartyl-tRNA synthetase YP_003045034.1 1927520 R 413997 CDS YP_003045035.1 254161927 8178536 1929602..1930168 1 NC_012967.1 similar to b1867; hypothetical protein 1930168 yecD 8178536 yecD Escherichia coli B str. REL606 hypothetical protein YP_003045035.1 1929602 D 413997 CDS YP_003045036.1 254161928 8176411 1930165..1930983 1 NC_012967.1 similar to b1868; hypothetical protein 1930983 yecE 8176411 yecE Escherichia coli B str. REL606 hypothetical protein YP_003045036.1 1930165 D 413997 CDS YP_003045037.1 254161929 8176412 1931036..1931431 1 NC_012967.1 similar to b1869; putative inner membrane protein 1931431 yecN 8176412 yecN Escherichia coli B str. REL606 putative inner membrane protein YP_003045037.1 1931036 D 413997 CDS YP_003045038.1 254161930 8176413 1931472..1932215 1 NC_012967.1 similar to b1870; putative methyltransferase 1932215 yecO 8176413 yecO Escherichia coli B str. REL606 putative methyltransferase YP_003045038.1 1931472 D 413997 CDS YP_003045039.1 254161931 8176414 1932212..1933183 1 NC_012967.1 similar to b1871; putative S-adenosyl-L-methionine-dependent methyltransferase 1933183 yecP 8176414 yecP Escherichia coli B str. REL606 putative S-adenosyl-L-methionine-dependent methyltransferase YP_003045039.1 1932212 D 413997 CDS YP_003045040.1 254161932 8176415 complement(1933348..1935777) 1 NC_012967.1 similar to b1872; trimethylamine N-oxide reductase system III, catalytic subunit 1935777 torZ 8176415 torZ Escherichia coli B str. REL606 trimethylamine N-oxide reductase system III, catalytic subunit YP_003045040.1 1933348 R 413997 CDS YP_003045041.1 254161933 8176416 complement(1935802..1936902) 1 NC_012967.1 similar to b1873; TMAO reductase III (TorYZ), cytochrome c-type subunit 1936902 torY 8176416 torY Escherichia coli B str. REL606 TMAO reductase III (TorYZ), cytochrome c-type subunit YP_003045041.1 1935802 R 413997 CDS YP_003045042.1 254161934 8176417 complement(1937290..1937730) 1 NC_012967.1 similar to b1874; copper homeostasis protein 1937730 cutC 8176417 cutC Escherichia coli B str. REL606 copper homeostasis protein YP_003045042.1 1937290 R 413997 CDS YP_003045043.1 254161935 8176418 complement(1938050..1938616) 1 NC_012967.1 similar to b1875; hypothetical protein 1938616 yecM 8176418 yecM Escherichia coli B str. REL606 hypothetical protein YP_003045043.1 1938050 R 413997 CDS YP_003045044.1 254161936 8176419 1938832..1940565 1 NC_012967.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1940565 argS 8176419 argS Escherichia coli B str. REL606 arginyl-tRNA synthetase YP_003045044.1 1938832 D 413997 CDS YP_003045045.1 254161937 8176420 1940742..1941230 1 NC_012967.1 similar to b1877; hypothetical protein 1941230 yecT 8176420 yecT Escherichia coli B str. REL606 hypothetical protein YP_003045045.1 1940742 D 413997 CDS YP_003045046.1 254161938 8176421 complement(1941350..1941718) 1 NC_012967.1 similar to b1878; hypothetical protein 1941718 flhE 8176421 flhE Escherichia coli B str. REL606 hypothetical protein YP_003045046.1 1941350 R 413997 CDS YP_003045047.1 254161939 8176422 complement(1941742..1943820) 1 NC_012967.1 membrane protein involved in the flagellar export apparatus; flagellar biosynthesis protein FlhA 1943820 flhA 8176422 flhA Escherichia coli B str. REL606 flagellar biosynthesis protein FlhA YP_003045047.1 1941742 R 413997 CDS YP_003045048.1 254161940 8176423 complement(1943813..1944961) 1 NC_012967.1 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export; flagellar biosynthesis protein FlhB 1944961 flhB 8176423 flhB Escherichia coli B str. REL606 flagellar biosynthesis protein FlhB YP_003045048.1 1943813 R 413997 CDS YP_003045049.1 254161941 8176424 complement(1945163..1945807) 1 NC_012967.1 cytosolic phosphatase which functions in the chemotaxis signal transduction complex by controlling the level of phosphorylated CheY through dephosphorylation; chemotaxis regulator CheZ 1945807 cheZ 8176424 cheZ Escherichia coli B str. REL606 chemotaxis regulator CheZ YP_003045049.1 1945163 R 413997 CDS YP_003045050.1 254161942 8178537 complement(1945818..1946207) 1 NC_012967.1 chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble; chemotaxis regulatory protein CheY 1946207 cheY 8178537 cheY Escherichia coli B str. REL606 chemotaxis regulatory protein CheY YP_003045050.1 1945818 R 413997 CDS YP_003045051.1 254161943 8176425 complement(1946222..1947271) 1 NC_012967.1 regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins; chemotaxis-specific methylesterase 1947271 cheB 8176425 cheB Escherichia coli B str. REL606 chemotaxis-specific methylesterase YP_003045051.1 1946222 R 413997 CDS YP_003045052.1 254161944 8176426 complement(1947274..1948134) 1 NC_012967.1 methylates the MCP; chemotaxis methyltransferase CheR 1948134 cheR 8176426 cheR Escherichia coli B str. REL606 chemotaxis methyltransferase CheR YP_003045052.1 1947274 R 413997 CDS YP_003045053.1 254161945 8176427 complement(1948153..1949754) 1 NC_012967.1 mediates taxis toward dipeptides; methyl-accepting protein IV 1949754 tap 8176427 tap Escherichia coli B str. REL606 methyl-accepting protein IV YP_003045053.1 1948153 R 413997 CDS YP_003045054.1 254161946 8176428 complement(1949800..1951461) 1 NC_012967.1 similar to b1886; methyl-accepting chemotaxis protein II 1951461 tar 8176428 tar Escherichia coli B str. REL606 methyl-accepting chemotaxis protein II YP_003045054.1 1949800 R 413997 CDS YP_003045055.1 254161947 8176429 complement(1951606..1952109) 1 NC_012967.1 similar to b1887; purine-binding chemotaxis protein 1952109 cheW 8176429 cheW Escherichia coli B str. REL606 purine-binding chemotaxis protein YP_003045055.1 1951606 R 413997 CDS YP_003045056.1 254161948 8176430 complement(1952130..1954094) 1 NC_012967.1 chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY; sensory histidine kinase/signal sensing protein; CheA is the histidine kinase component; chemotaxis protein CheA 1954094 cheA 8176430 cheA Escherichia coli B str. REL606 chemotaxis protein CheA YP_003045056.1 1952130 R 413997 CDS YP_003045057.1 254161949 8176431 complement(1954099..1955025) 1 NC_012967.1 with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotB 1955025 motB 8176431 motB Escherichia coli B str. REL606 flagellar motor protein MotB YP_003045057.1 1954099 R 413997 CDS YP_003045058.1 254161950 8179085 complement(1955022..1955909) 1 NC_012967.1 With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotA 1955909 motA 8179085 motA Escherichia coli B str. REL606 flagellar motor protein MotA YP_003045058.1 1955022 R 413997 CDS YP_003045059.1 254161951 8176432 complement(1956036..1956614) 1 NC_012967.1 With FlhD is involved in the activation of class 2 flagellar genes and as well as a number of other genetic systems; transcriptional activator FlhC 1956614 flhC 8176432 flhC Escherichia coli B str. REL606 transcriptional activator FlhC YP_003045059.1 1956036 R 413997 CDS YP_003045060.1 254161952 8179086 complement(1956617..1956976) 1 NC_012967.1 with FlhC is involved in the activation of class 2 flagellar genes and is involved in the regulation of a number of other genetic systems; transcriptional activator FlhD 1956976 flhD 8179086 flhD Escherichia coli B str. REL606 transcriptional activator FlhD YP_003045060.1 1956617 R 413997 CDS YP_003045061.1 254161953 8179087 1957747..1958175 1 NC_012967.1 ppGpp-dependent; membrane-associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress; universal stress protein UspC 1958175 yecG 8179087 yecG Escherichia coli B str. REL606 universal stress protein UspC YP_003045061.1 1957747 D 413997 CDS YP_003045062.1 254161954 8176433 complement(1958182..1959606) 1 NC_012967.1 similar to b1896; trehalose-6-phosphate synthase 1959606 otsA 8176433 otsA Escherichia coli B str. REL606 trehalose-6-phosphate synthase YP_003045062.1 1958182 R 413997 CDS YP_003045063.1 254161955 8176434 complement(1959581..1960381) 1 NC_012967.1 biosynthetic; catalyzes the formation of trehalose and phosphate from trehalose-6-phosphate; expression is increased under osmotic stress and induced during the transition to stationary phase and by decreased temperature; trehalose-6-phosphate phosphatase 1960381 otsB 8176434 otsB Escherichia coli B str. REL606 trehalose-6-phosphate phosphatase YP_003045063.1 1959581 R 413997 CDS YP_003045064.1 254161956 8176435 complement(1960548..1961537) 1 NC_012967.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose transporter permease 1961537 araH 8176435 araH Escherichia coli B str. REL606 L-arabinose transporter permease YP_003045064.1 1960548 R 413997 CDS YP_003045065.1 254161957 8176436 complement(1961549..1963063) 1 NC_012967.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose transporter ATP-binding protein 1963063 araG 8176436 araG Escherichia coli B str. REL606 L-arabinose transporter ATP-binding protein YP_003045065.1 1961549 R 413997 CDS YP_003045066.1 254161958 8176437 complement(1963133..1964122) 1 NC_012967.1 similar to b1901; L-arabinose transporter subunit 1964122 araF 8176437 araF Escherichia coli B str. REL606 L-arabinose transporter subunit YP_003045066.1 1963133 R 413997 CDS YP_003045067.1 254161959 8176438 1964919..1965422 1 NC_012967.1 similar to b1902; putative ferritin-like protein 1965422 yecI 8176438 yecI Escherichia coli B str. REL606 putative ferritin-like protein YP_003045067.1 1964919 D 413997 CDS YP_003045068.1 254161960 8176439 complement(1965501..1965752) 1 NC_012967.1 similar to b4537; hypothetical protein 1965752 yecJ 8176439 yecJ Escherichia coli B str. REL606 hypothetical protein YP_003045068.1 1965501 R 413997 CDS YP_003045069.1 254161961 8176440 1966216..1966539 1 NC_012967.1 similar to b1904; hypothetical protein 1966539 yecR 8176440 yecR Escherichia coli B str. REL606 hypothetical protein YP_003045069.1 1966216 D 413997 CDS YP_003045070.1 254161962 8179088 1966711..1967208 1 NC_012967.1 cytoplasmic iron storage protein; ferritin 1967208 ftn 8179088 ftn Escherichia coli B str. REL606 ferritin YP_003045070.1 1966711 D 413997 CDS YP_003045071.1 254161963 8176441 complement(1967246..1967485) 1 NC_012967.1 similar to b1906; hypothetical protein 1967485 yecH 8176441 yecH Escherichia coli B str. REL606 hypothetical protein YP_003045071.1 1967246 R 413997 CDS YP_003045072.1 254161964 8178538 1967675..1968886 1 NC_012967.1 similar to b1907; tyrosine transporter 1968886 tyrP 8178538 tyrP Escherichia coli B str. REL606 tyrosine transporter YP_003045072.1 1967675 D 413997 CDS YP_003045073.1 254161965 8179089 complement(1968948..1969613) 1 NC_012967.1 similar to b1908; hypothetical protein 1969613 yecA 8179089 yecA Escherichia coli B str. REL606 hypothetical protein YP_003045073.1 1968948 R 413997 CDS YP_003045074.1 254161966 8176444 complement(1970262..1970810) 1 NC_012967.1 similar to b1912; phosphatidylglycerophosphate synthetase 1970810 pgsA 8176444 pgsA Escherichia coli B str. REL606 phosphatidylglycerophosphate synthetase YP_003045074.1 1970262 R 413997 CDS YP_003045075.1 254161967 8176445 complement(1970867..1972633) 1 NC_012967.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 1972633 uvrC 8176445 uvrC Escherichia coli B str. REL606 excinuclease ABC subunit C YP_003045075.1 1970867 R 413997 CDS YP_003045076.1 254161968 8179090 complement(1972696..1973205) 1 NC_012967.1 similar to b1914; response regulator 1973205 uvrY 8179090 uvrY Escherichia coli B str. REL606 response regulator YP_003045076.1 1972696 R 413997 CDS YP_003045077.1 254161969 8176446 1973327..1973602 1 NC_012967.1 IS1 protein InsA 1973602 insA-13 8176446 insA-13 Escherichia coli B str. REL606 IS1 protein InsA YP_003045077.1 1973327 D 413997 CDS YP_003045078.1 254161970 8176447 1973521..1974024 1 NC_012967.1 IS1 protein InsB 1974024 insB-13 8176447 insB-13 Escherichia coli B str. REL606 IS1 protein InsB YP_003045078.1 1973521 D 413997 CDS YP_003045079.1 254161971 8176448 1974026..1974685 1 NC_012967.1 Hsp31 stabilizes early unfolding protein intermediates under severe heat stress; chaperone protein HchA 1974685 yedU 8176448 yedU Escherichia coli B str. REL606 chaperone protein HchA YP_003045079.1 1974026 D 413997 CDS YP_003045080.1 254161972 8176449 complement(1974793..1976151) 1 NC_012967.1 similar to b1968; putative sensory kinase in two-component regulatory system with YedW 1976151 yedV 8176449 yedV Escherichia coli B str. REL606 putative sensory kinase in two-component regulatory system with YedW YP_003045080.1 1974793 R 413997 CDS YP_003045081.1 254161973 8176450 complement(1976151..1976822) 1 NC_012967.1 induced by CusR in the presence of copper; YedW induces the expression of the upstream gene yedV (encoding a sensor kinase) as well as yedW; yedVW is one of four copper regulons found in E. coli; part of the copper homeostasis mechanism; confers resistance to copper and several drugs when induced; transcriptional regulatory protein YedW 1976822 yedW 8176450 yedW Escherichia coli B str. REL606 transcriptional regulatory protein YedW YP_003045081.1 1976151 R 413997 CDS YP_003045082.1 254161974 8176451 1976955..1977368 1 NC_012967.1 similar to b1970; hypothetical protein 1977368 yedX 8176451 yedX Escherichia coli B str. REL606 hypothetical protein YP_003045082.1 1976955 D 413997 CDS YP_003045083.1 254161975 8176452 1977477..1978481 1 NC_012967.1 in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ; putative sulfite oxidase subunit YedY 1978481 yedY 8176452 yedY Escherichia coli B str. REL606 putative sulfite oxidase subunit YedY YP_003045083.1 1977477 D 413997 CDS YP_003045084.1 254161976 8178540 1978482..1979117 1 NC_012967.1 in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme; putative sulfite oxidase subunit YedZ 1979117 yedZ 8178540 yedZ Escherichia coli B str. REL606 putative sulfite oxidase subunit YedZ YP_003045084.1 1978482 D 413997 CDS YP_003045085.1 254161977 8176453 1979374..1980024 1 NC_012967.1 similar to b1973; hypothetical protein 1980024 yodA 8176453 yodA Escherichia coli B str. REL606 hypothetical protein YP_003045085.1 1979374 D 413997 CDS YP_003045086.1 254161978 8176454 1980367..1980897 1 NC_012967.1 similar to b1974; putative cytochrome 1980897 yodB 8176454 yodB Escherichia coli B str. REL606 putative cytochrome YP_003045086.1 1980367 D 413997 CDS YP_003045087.1 254161979 8176456 1981650..1982447 1 NC_012967.1 similar to b1976; hypothetical protein 1982447 yeeI 8176456 yeeI Escherichia coli B str. REL606 hypothetical protein YP_003045087.1 1981650 D 413997 CDS YP_003045088.1 254161980 8176458 1982862..1990013 1 NC_012967.1 similar to b1978; adhesin 1990013 yeeJ 8176458 yeeJ Escherichia coli B str. REL606 adhesin YP_003045088.1 1982862 D 413997 CDS YP_003045089.1 254161981 8176460 1991642..1992958 1 NC_012967.1 similar to b1981; shikimate transporter 1992958 shiA 8176460 shiA Escherichia coli B str. REL606 shikimate transporter YP_003045089.1 1991642 D 413997 CDS YP_003045090.1 254161982 8176461 1993060..1994514 1 NC_012967.1 Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile; AMP nucleosidase 1994514 amn 8176461 amn Escherichia coli B str. REL606 AMP nucleosidase YP_003045090.1 1993060 D 413997 CDS YP_003045091.1 254161983 8176462 1994857..1995573 1 NC_012967.1 similar to b1983; hypothetical protein 1995573 yeeN 8176462 yeeN Escherichia coli B str. REL606 hypothetical protein YP_003045091.1 1994857 D 413997 CDS YP_003045092.1 254161984 8176464 complement(1996203..1997846) 1 NC_012967.1 similar to b1985; hypothetical protein 1997846 yeeO 8176464 yeeO Escherichia coli B str. REL606 hypothetical protein YP_003045092.1 1996203 R 413997 CDS YP_003045093.1 254161985 8176466 complement(1997964..1998914) 1 NC_012967.1 LysR-type transcriptional regulator similar to CysB; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates two operons consisting of ABC transporters that are part of the cys regulon; regulated by CysB; transcriptional regulator Cbl 1998914 cbl 8176466 cbl Escherichia coli B str. REL606 transcriptional regulator Cbl YP_003045093.1 1997964 R 413997 CDS YP_003045094.1 254161986 8176467 complement(1999016..1999933) 1 NC_012967.1 Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation; nitrogen assimilation transcriptional regulator 1999933 nac 8176467 nac Escherichia coli B str. REL606 nitrogen assimilation transcriptional regulator YP_003045094.1 1999016 R 413997 CDS YP_003045095.1 254161987 8179091 complement(2000391..2001323) 1 NC_012967.1 similar to b1990; hypothetical protein 2001323 erfK 8179091 erfK Escherichia coli B str. REL606 hypothetical protein YP_003045095.1 2000391 R 413997 CDS YP_003045096.1 254161988 8179092 complement(2001388..2002467) 1 NC_012967.1 catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 2002467 cobT 8179092 cobT Escherichia coli B str. REL606 nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase YP_003045096.1 2001388 R 413997 CDS YP_003045097.1 254161989 8176469 complement(2002479..2003222) 1 NC_012967.1 catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole; cobalamin synthase 2003222 cobS 8176469 cobS Escherichia coli B str. REL606 cobalamin synthase YP_003045097.1 2002479 R 413997 CDS YP_003045098.1 254161990 8176470 complement(2003219..2003764) 1 NC_012967.1 catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP; adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase 2003764 cobU 8176470 cobU Escherichia coli B str. REL606 adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase YP_003045098.1 2003219 R 413997 CDS YP_003045099.1 254161991 8176472 complement(2005753..2006658) 1 NC_012967.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 2006658 insD 8176472 insD Escherichia coli B str. REL606 insertion element IS2 transposase InsD YP_003045099.1 2005753 R 413997 CDS YP_003045100.1 254161992 8176473 complement(2007531..2007938) 1 NC_012967.1 hypothetical protein 2007938 8176473 ECB_01906 Escherichia coli B str. REL606 hypothetical protein YP_003045100.1 2007531 R 413997 CDS YP_003045101.1 254161993 8176474 complement(2007926..2008360) 1 NC_012967.1 hypothetical protein 2008360 8176474 ECB_01907 Escherichia coli B str. REL606 hypothetical protein YP_003045101.1 2007926 R 413997 CDS YP_003045102.1 254161994 8178542 2008293..2008703 1 NC_012967.1 hypothetical protein 2008703 8178542 ECB_01908 Escherichia coli B str. REL606 hypothetical protein YP_003045102.1 2008293 D 413997 CDS YP_003045103.1 254161995 8176475 complement(2008992..2009150) 1 NC_012967.1 hypothetical protein 2009150 yoeD 8176475 yoeD Escherichia coli B str. REL606 hypothetical protein YP_003045103.1 2008992 R 413997 CDS YP_003045104.1 254161996 8176476 complement(2009475..2009870) 1 NC_012967.1 similar to b2007; hypothetical protein 2009870 yeeX 8176476 yeeX Escherichia coli B str. REL606 hypothetical protein YP_003045104.1 2009475 R 413997 CDS YP_003045105.1 254161997 8176477 complement(2009976..2011034) 1 NC_012967.1 similar to b2008; inner membrane protein 2011034 yeeA 8176477 yeeA Escherichia coli B str. REL606 inner membrane protein YP_003045105.1 2009976 R 413997 CDS YP_003045106.1 254161998 8176478 complement(2011232..2011705) 1 NC_012967.1 similar to b2009; DNA gyrase inhibitor 2011705 sbmC 8176478 sbmC Escherichia coli B str. REL606 DNA gyrase inhibitor YP_003045106.1 2011232 R 413997 CDS YP_003045107.1 254161999 8178543 complement(2011824..2012990) 1 NC_012967.1 removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; penicillin-binding protein 6B; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase 2012990 dacD 8178543 dacD Escherichia coli B str. REL606 D-alanyl-D-alanine carboxypeptidase YP_003045107.1 2011824 R 413997 CDS YP_003045108.1 254162000 8176479 2013199..2014626 1 NC_012967.1 Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates; exonuclease I 2014626 sbcB 8176479 sbcB Escherichia coli B str. REL606 exonuclease I YP_003045108.1 2013199 D 413997 CDS YP_003045109.1 254162001 8178544 complement(2014669..2014896) 1 NC_012967.1 similar to b2012; hypothetical protein 2014896 yeeD 8178544 yeeD Escherichia coli B str. REL606 hypothetical protein YP_003045109.1 2014669 R 413997 CDS YP_003045110.1 254162002 8178545 complement(2014910..2015968) 1 NC_012967.1 similar to b2013; putative inner membrane protein 2015968 yeeE 8178545 yeeE Escherichia coli B str. REL606 putative inner membrane protein YP_003045110.1 2014910 R 413997 CDS YP_003045111.1 254162003 8176480 complement(2016147..2017505) 1 NC_012967.1 similar to b2014; putative amino-acid transporter 2017505 yeeF 8176480 yeeF Escherichia coli B str. REL606 putative amino-acid transporter YP_003045111.1 2016147 R 413997 CDS YP_003045112.1 254162004 8176481 complement(2017772..2018701) 1 NC_012967.1 similar to b2015; putative DNA-binding transcriptional regulator 2018701 yeeY 8176481 yeeY Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003045112.1 2017772 R 413997 CDS YP_003045113.1 254162005 8179093 complement(2018747..2019571) 1 NC_012967.1 similar to b2016; putative epimerase, with NAD(P)-binding Rossmann-fold domain 2019571 yeeZ 8179093 yeeZ Escherichia coli B str. REL606 putative epimerase, with NAD(P)-binding Rossmann-fold domain YP_003045113.1 2018747 R 413997 CDS YP_003045115.1 254162007 8176483 2020194..2021093 1 NC_012967.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase 2021093 hisG 8176483 hisG Escherichia coli B str. REL606 ATP phosphoribosyltransferase YP_003045115.1 2020194 D 413997 CDS YP_003045116.1 254162008 8179094 2021162..2022403 1 NC_012967.1 similar to b2020; histidinol dehydrogenase 2022403 hisD 8179094 hisD Escherichia coli B str. REL606 histidinol dehydrogenase YP_003045116.1 2021162 D 413997 CDS YP_003045117.1 254162009 8176484 2022400..2023470 1 NC_012967.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 2023470 hisC 8176484 hisC Escherichia coli B str. REL606 histidinol-phosphate aminotransferase YP_003045117.1 2022400 D 413997 CDS YP_003045118.1 254162010 8176485 2023470..2024537 1 NC_012967.1 catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate; imidazole glycerol-phosphate dehydratase/histidinol phosphatase 2024537 hisB 8176485 hisB Escherichia coli B str. REL606 imidazole glycerol-phosphate dehydratase/histidinol phosphatase YP_003045118.1 2023470 D 413997 CDS YP_003045119.1 254162011 8176486 2024537..2025127 1 NC_012967.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 2025127 hisH 8176486 hisH Escherichia coli B str. REL606 imidazole glycerol phosphate synthase subunit HisH YP_003045119.1 2024537 D 413997 CDS YP_003045120.1 254162012 8179095 2025127..2025864 1 NC_012967.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 2025864 hisA 8179095 hisA Escherichia coli B str. REL606 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase YP_003045120.1 2025127 D 413997 CDS YP_003045121.1 254162013 8176487 2025846..2026622 1 NC_012967.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 2026622 hisF 8176487 hisF Escherichia coli B str. REL606 imidazole glycerol phosphate synthase subunit HisF YP_003045121.1 2025846 D 413997 CDS YP_003045122.1 254162014 8176488 2026616..2027227 1 NC_012967.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis; bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein 2027227 hisI 8176488 hisI Escherichia coli B str. REL606 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein YP_003045122.1 2026616 D 413997 CDS YP_003045123.1 254162015 8176489 complement(2027323..2028306) 1 NC_012967.1 similar to b2027; regulator of length of O-antigen component of lipopolysaccharide chains 2028306 wzzB 8176489 wzzB Escherichia coli B str. REL606 regulator of length of O-antigen component of lipopolysaccharide chains YP_003045123.1 2027323 R 413997 CDS YP_003045124.1 254162016 8176490 complement(2028449..2029615) 1 NC_012967.1 similar to b2028; UDP-glucose 6-dehydrogenase 2029615 ugd 8176490 ugd Escherichia coli B str. REL606 UDP-glucose 6-dehydrogenase YP_003045124.1 2028449 R 413997 CDS YP_003045125.1 254162017 8176491 complement(2029863..2031269) 1 NC_012967.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 2031269 gnd 8176491 gnd Escherichia coli B str. REL606 6-phosphogluconate dehydrogenase YP_003045125.1 2029863 R 413997 CDS YP_003045126.1 254162018 8176492 complement(2031433..2032797) 1 NC_012967.1 Phosphomannomutase 2032797 manB 8176492 manB Escherichia coli B str. REL606 Phosphomannomutase YP_003045126.1 2031433 R 413997 CDS YP_003045127.1 254162019 8178546 complement(2032831..2034255) 1 NC_012967.1 Mannose-1-phosphate guanylyltransferase 2034255 manC 8178546 manC Escherichia coli B str. REL606 Mannose-1-phosphate guanylyltransferase YP_003045127.1 2032831 R 413997 CDS YP_003045128.1 254162020 8176493 complement(2034341..2034844) 1 NC_012967.1 IS1 protein InsB 2034844 insB-14 8176493 insB-14 Escherichia coli B str. REL606 IS1 protein InsB YP_003045128.1 2034341 R 413997 CDS YP_003045129.1 254162021 8176494 complement(2034763..2035038) 1 NC_012967.1 IS1 protein InsA 2035038 insA-14 8176494 insA-14 Escherichia coli B str. REL606 IS1 protein InsA YP_003045129.1 2034763 R 413997 CDS YP_003045130.1 254162022 8176495 complement(2035089..2035856) 1 NC_012967.1 putative glycosyltransferase WbbD 2035856 wbbD 8176495 wbbD Escherichia coli B str. REL606 putative glycosyltransferase WbbD YP_003045130.1 2035089 R 413997 CDS YP_003045131.1 254162023 8176496 complement(2035846..2036958) 1 NC_012967.1 putative glycosyltransferase WbbC 2036958 wbbC 8176496 wbbC Escherichia coli B str. REL606 putative glycosyltransferase WbbC YP_003045131.1 2035846 R 413997 CDS YP_003045132.1 254162024 8176497 complement(2036955..2038130) 1 NC_012967.1 O antigen polymerase (Wzy) 2038130 wzy 8176497 wzy Escherichia coli B str. REL606 O antigen polymerase (Wzy) YP_003045132.1 2036955 R 413997 CDS YP_003045133.1 254162025 8179096 complement(2038127..2038948) 1 NC_012967.1 putative glycosyltransferase WbbB 2038948 wbbB 8179096 wbbB Escherichia coli B str. REL606 putative glycosyltransferase WbbB YP_003045133.1 2038127 R 413997 CDS YP_003045134.1 254162026 8176498 complement(2038948..2039694) 1 NC_012967.1 putative glycosyltransferase WbbA 2039694 wbbA 8176498 wbbA Escherichia coli B str. REL606 putative glycosyltransferase WbbA YP_003045134.1 2038948 R 413997 CDS YP_003045135.1 254162027 8176499 complement(2039691..2040128) 1 NC_012967.1 involved in dTDP-N-acetylviosamine synthesis; VioB 2040128 vioB 8176499 vioB Escherichia coli B str. REL606 VioB YP_003045135.1 2039691 R 413997 CDS YP_003045136.1 254162028 8176500 complement(2040271..2041383) 1 NC_012967.1 involved in dTDP-N-acetylviosamine synthesis; VioA 2041383 vioA 8176500 vioA Escherichia coli B str. REL606 VioA YP_003045136.1 2040271 R 413997 CDS YP_003045137.1 254162029 8179097 complement(2041393..2042820) 1 NC_012967.1 O antigen translocase (Wzx) 2042820 wzx 8179097 wzx Escherichia coli B str. REL606 O antigen translocase (Wzx) YP_003045137.1 2041393 R 413997 CDS YP_003045138.1 254162030 8176501 complement(2042821..2043366) 1 NC_012967.1 dTDP-4-dehydrorhamnose 3,5-epimerase RmlC 2043366 rmlC 8176501 rmlC Escherichia coli B str. REL606 dTDP-4-dehydrorhamnose 3,5-epimerase RmlC YP_003045138.1 2042821 R 413997 CDS YP_003045139.1 254162031 8176502 complement(2043371..2044249) 1 NC_012967.1 similar to b2039; glucose-1-phosphate thymidylyltransferase 2044249 rfbA 8176502 rfbA Escherichia coli B str. REL606 glucose-1-phosphate thymidylyltransferase YP_003045139.1 2043371 R 413997 CDS YP_003045140.1 254162032 8179098 complement(2044308..2045207) 1 NC_012967.1 with dTDP-4-dehydrorhamnose 3,5-epimerase forms a complex known as dTDP-L-rhamnose synthetase; catalyzes the reduction of dTDP-4-dehydro-6-deoxy-L-mannose to dTDP-L-rhamnose; dTDP-4-dehydrorhamnose reductase 2045207 rfbD 8179098 rfbD Escherichia coli B str. REL606 dTDP-4-dehydrorhamnose reductase YP_003045140.1 2044308 R 413997 CDS YP_003045141.1 254162033 8176503 complement(2045207..2046292) 1 NC_012967.1 NAD(P) binding; catalyzes the formation of dTDP-4-dehydro-6-deoxy-D-glucose from dTDP-glucose; dTDP-glucose 4,6 dehydratase 2046292 rfbB 8176503 rfbB Escherichia coli B str. REL606 dTDP-glucose 4,6 dehydratase YP_003045141.1 2045207 R 413997 CDS YP_003045142.1 254162034 8176504 complement(2046665..2047558) 1 NC_012967.1 together with GalU subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; UTP--glucose-1-phosphate uridylyltransferase subunit GalF 2047558 galF 8176504 galF Escherichia coli B str. REL606 UTP--glucose-1-phosphate uridylyltransferase subunit GalF YP_003045142.1 2046665 R 413997 CDS YP_003045143.1 254162035 8176505 complement(2047733..2049127) 1 NC_012967.1 WcaM from Salmonella enterica is essential for biofilm formation on HEp-2 cells and chicken intestinal tissue but not on a plastic surface; may be involved in the biosynthesis of colanic acid; putative colanic acid biosynthesis protein 2049127 wcaM 8176505 wcaM Escherichia coli B str. REL606 putative colanic acid biosynthesis protein YP_003045143.1 2047733 R 413997 CDS YP_003045144.1 254162036 8176506 complement(2049138..2050358) 1 NC_012967.1 similar to b2044; putative glycosyl transferase 2050358 wcaL 8176506 wcaL Escherichia coli B str. REL606 putative glycosyl transferase YP_003045144.1 2049138 R 413997 CDS YP_003045145.1 254162037 8178547 complement(2050355..2051635) 1 NC_012967.1 similar to b2045; putative pyruvyl transferase 2051635 wcaK 8178547 wcaK Escherichia coli B str. REL606 putative pyruvyl transferase YP_003045145.1 2050355 R 413997 CDS YP_003045146.1 254162038 8178548 complement(2051797..2053275) 1 NC_012967.1 similar to b2046; colanic acid exporter 2053275 wzxC 8178548 wzxC Escherichia coli B str. REL606 colanic acid exporter YP_003045146.1 2051797 R 413997 CDS YP_003045147.1 254162039 8176507 complement(2053277..2054671) 1 NC_012967.1 WcaJ; glucose-1-phosphate transferase responsible for the addition of the first glucose-1-phosphate from UDP-glucose to the lipid carrier undecaprenyl phosphate in the biosynthesis of colanic acid; putative UDP-glucose lipid carrier transferase 2054671 wcaJ 8176507 wcaJ Escherichia coli B str. REL606 putative UDP-glucose lipid carrier transferase YP_003045147.1 2053277 R 413997 CDS YP_003045148.1 254162040 8176508 complement(2054726..2056096) 1 NC_012967.1 similar to b2048; phosphomannomutase 2056096 cpsG 8176508 cpsG Escherichia coli B str. REL606 phosphomannomutase YP_003045148.1 2054726 R 413997 CDS YP_003045149.1 254162041 8176509 complement(2056289..2057725) 1 NC_012967.1 similar to b2049; mannose-1-phosphate guanyltransferase 2057725 cpsB 8176509 cpsB Escherichia coli B str. REL606 mannose-1-phosphate guanyltransferase YP_003045149.1 2056289 R 413997 CDS YP_003045150.1 254162042 8176510 complement(2057728..2058951) 1 NC_012967.1 similar to b2050; putative glycosyl transferase 2058951 wcaI 8176510 wcaI Escherichia coli B str. REL606 putative glycosyl transferase YP_003045150.1 2057728 R 413997 CDS YP_003045151.1 254162043 8176511 complement(2058948..2059427) 1 NC_012967.1 similar to b2051; GDP-mannose mannosyl hydrolase 2059427 wcaH 8176511 wcaH Escherichia coli B str. REL606 GDP-mannose mannosyl hydrolase YP_003045151.1 2058948 R 413997 CDS YP_003045152.1 254162044 8176512 complement(2059430..2060395) 1 NC_012967.1 similar to b2052; bifunctional GDP-fucose synthetase: GDP-4-dehydro-6-deoxy-D-mannose epimerase/ GDP-4-dehydro-6-L-deoxygalactose reductase 2060395 wcaG 8176512 wcaG Escherichia coli B str. REL606 bifunctional GDP-fucose synthetase: GDP-4-dehydro-6-deoxy-D-mannose epimerase/ GDP-4-dehydro-6-L-deoxygalactose reductase YP_003045152.1 2059430 R 413997 CDS YP_003045153.1 254162045 8176513 complement(2060398..2061519) 1 NC_012967.1 similar to b2053; GDP-D-mannose dehydratase 2061519 gmd 8176513 gmd Escherichia coli B str. REL606 GDP-D-mannose dehydratase YP_003045153.1 2060398 R 413997 CDS YP_003045154.1 254162046 8176514 complement(2061546..2062094) 1 NC_012967.1 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); putative colanic acid biosynthesis acetyltransferase WcaF 2062094 wcaF 8176514 wcaF Escherichia coli B str. REL606 putative colanic acid biosynthesis acetyltransferase WcaF YP_003045154.1 2061546 R 413997 CDS YP_003045155.1 254162047 8176515 complement(2062110..2062856) 1 NC_012967.1 similar to b2055; putative glycosyl transferase 2062856 wcaE 8176515 wcaE Escherichia coli B str. REL606 putative glycosyl transferase YP_003045155.1 2062110 R 413997 CDS YP_003045156.1 254162048 8179099 complement(2062867..2064084) 1 NC_012967.1 essential for colanic acid biosynthesis; colanic acid is an exopolysaccharide produced under stress conditions that confers acid and heat tolerance; putative colanic acid biosynthesis protein 2064084 wcaD 8179099 wcaD Escherichia coli B str. REL606 putative colanic acid biosynthesis protein YP_003045156.1 2062867 R 413997 CDS YP_003045157.1 254162049 8176516 complement(2064059..2065276) 1 NC_012967.1 similar to b2057; putative glycosyl transferase 2065276 wcaC 8176516 wcaC Escherichia coli B str. REL606 putative glycosyl transferase YP_003045157.1 2064059 R 413997 CDS YP_003045158.1 254162050 8176517 complement(2065273..2065761) 1 NC_012967.1 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); wcaB is induced in sessile bacteria and by osmotic shock, and repressed when grown in rich medium; putative colanic acid biosynthesis acetyltransferase WcaB 2065761 wcaB 8176517 wcaB Escherichia coli B str. REL606 putative colanic acid biosynthesis acetyltransferase WcaB YP_003045158.1 2065273 R 413997 CDS YP_003045159.1 254162051 8176518 complement(2065764..2066603) 1 NC_012967.1 similar to b2059; putative glycosyl transferase 2066603 wcaA 8176518 wcaA Escherichia coli B str. REL606 putative glycosyl transferase YP_003045159.1 2065764 R 413997 CDS YP_003045160.1 254162052 8176519 complement(2066696..2068858) 1 NC_012967.1 Wzc; catalyzes the autophosphorylation on tyrosine residues which downregulates the biosynthesis of colonic acid (an extracellular polysaccharide); tyrosine kinase 2068858 wzc 8176519 wzc Escherichia coli B str. REL606 tyrosine kinase YP_003045160.1 2066696 R 413997 CDS YP_003045161.1 254162053 8176520 complement(2068861..2069304) 1 NC_012967.1 Wzb shows phosphatase activity towards the autophosphorylated Wzc protein, which induces colanic acid biosynthesis; catalyzes the phosphorylation of UDP-glucose dehydrogenase, an enzyme involved in colanic acid biosynthesis; tyrosine phosphatase 2069304 wzb 8176520 wzb Escherichia coli B str. REL606 tyrosine phosphatase YP_003045161.1 2068861 R 413997 CDS YP_003045162.1 254162054 8176521 complement(2069310..2070449) 1 NC_012967.1 similar to b2062; lipoprotein required for capsular polysaccharide translocation through the outer membrane 2070449 wza 8176521 wza Escherichia coli B str. REL606 lipoprotein required for capsular polysaccharide translocation through the outer membrane YP_003045162.1 2069310 R 413997 CDS YP_003045163.1 254162055 8178549 2071108..2072691 1 NC_012967.1 similar to b2063; hypothetical protein 2072691 yegH 8178549 yegH Escherichia coli B str. REL606 hypothetical protein YP_003045163.1 2071108 D 413997 CDS YP_003045164.1 254162056 8176522 complement(2072965..2074818) 1 NC_012967.1 YegA; inner membrane protein involved in the assembly of outer membrane proteins (OMPs); asmA-null mutants show low lipopolysaccharide (LPS) levels, suggesting a role in LPS biogenesis and/or in restricting outer membrane fluidity, resulting on altered assembly of OMPs; putative assembly protein 2074818 asmA 8176522 asmA Escherichia coli B str. REL606 putative assembly protein YP_003045164.1 2072965 R 413997 CDS YP_003045165.1 254162057 8176523 complement(2074840..2075421) 1 NC_012967.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 2075421 dcd 8176523 dcd Escherichia coli B str. REL606 deoxycytidine triphosphate deaminase YP_003045165.1 2074840 R 413997 CDS YP_003045166.1 254162058 8176524 complement(2075513..2076154) 1 NC_012967.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase 2076154 udk 8176524 udk Escherichia coli B str. REL606 uridine kinase YP_003045166.1 2075513 R 413997 CDS YP_003045167.1 254162059 8176525 2076472..2079777 1 NC_012967.1 contains a MASE1 (Membrane-Associated Sensor) domain; potentially involved in signal transduction; putative sensor protein 2079777 yegE 8176525 yegE Escherichia coli B str. REL606 putative sensor protein YP_003045167.1 2076472 D 413997 CDS YP_003045168.1 254162060 8178550 complement(2079878..2080726) 1 NC_012967.1 inducible, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine; 3-methyl-adenine DNA glycosylase II 2080726 alkA 8178550 alkA Escherichia coli B str. REL606 3-methyl-adenine DNA glycosylase II YP_003045168.1 2079878 R 413997 CDS YP_003045169.1 254162061 8176526 2080860..2082212 1 NC_012967.1 similar to b2069; putative chaperone 2082212 yegD 8176526 yegD Escherichia coli B str. REL606 putative chaperone YP_003045169.1 2080860 D 413997 CDS YP_003045170.1 254162062 8176527 complement(2082225..2084165) 1 NC_012967.1 similar to b2070; hypothetical protein 2084165 yegI 8176527 yegI Escherichia coli B str. REL606 hypothetical protein YP_003045170.1 2082225 R 413997 CDS YP_003045171.1 254162063 8176528 complement(2084162..2084923) 1 NC_012967.1 similar to b2072; hypothetical protein 2084923 yegK 8176528 yegK Escherichia coli B str. REL606 hypothetical protein YP_003045171.1 2084162 R 413997 CDS YP_003045172.1 254162064 8176529 complement(2084920..2085579) 1 NC_012967.1 similar to b2073; hypothetical protein 2085579 yegL 8176529 yegL Escherichia coli B str. REL606 hypothetical protein YP_003045172.1 2084920 R 413997 CDS YP_003045173.1 254162065 8178551 2087124..2088371 1 NC_012967.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtA 2088371 yegM 8178551 yegM Escherichia coli B str. REL606 multidrug efflux system subunit MdtA YP_003045173.1 2087124 D 413997 CDS YP_003045174.1 254162066 8176530 2088371..2091493 1 NC_012967.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtB 2091493 yegN 8176530 yegN Escherichia coli B str. REL606 multidrug efflux system subunit MdtB YP_003045174.1 2088371 D 413997 CDS YP_003045175.1 254162067 8179100 2091494..2094571 1 NC_012967.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC; confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtC 2094571 yegO 8179100 yegO Escherichia coli B str. REL606 multidrug efflux system subunit MdtC YP_003045175.1 2091494 D 413997 CDS YP_003045176.1 254162068 8176531 2094572..2095987 1 NC_012967.1 similar to b2077; multidrug efflux system protein MdtE 2095987 yegB 8176531 yegB Escherichia coli B str. REL606 multidrug efflux system protein MdtE YP_003045176.1 2094572 D 413997 CDS YP_003045177.1 254162069 8176532 2095984..2097387 1 NC_012967.1 similar to b2078; signal transduction histidine-protein kinase BaeS 2097387 baeS 8176532 baeS Escherichia coli B str. REL606 signal transduction histidine-protein kinase BaeS YP_003045177.1 2095984 D 413997 CDS YP_003045178.1 254162070 8179101 2097384..2098106 1 NC_012967.1 response regulator in two-component regulatory system with BaeS; regulator of RNA synthesis, flagellar biosynthesis, chemotaxis and transport; DNA-binding transcriptional regulator BaeR 2098106 baeR 8179101 baeR Escherichia coli B str. REL606 DNA-binding transcriptional regulator BaeR YP_003045178.1 2097384 D 413997 CDS YP_003045179.1 254162071 8176533 2098297..2098629 1 NC_012967.1 similar to b2080; hypothetical protein 2098629 yegP 8176533 yegP Escherichia coli B str. REL606 hypothetical protein YP_003045179.1 2098297 D 413997 CDS YP_003045180.1 254162072 8176534 2098775..2100136 1 NC_012967.1 similar to b2081; putative peptidase 2100136 yegQ 8176534 yegQ Escherichia coli B str. REL606 putative peptidase YP_003045180.1 2098775 D 413997 CDS YP_003045181.1 254162073 8176535 complement(2100409..2100627) 1 NC_012967.1 in E. coli K-12 this is in prophage P2 remnant; DNA-binding transcriptional regulator 2100627 ogrK 8176535 ogrK Escherichia coli B str. REL606 DNA-binding transcriptional regulator YP_003045181.1 2100409 R 413997 CDS YP_003045182.1 254162074 8176536 complement(2100709..2101488) 1 NC_012967.1 similar to b2083; pseudo in K-12 MG1655; putative phage protein (D protein) 2101488 yegZ 8176536 yegZ Escherichia coli B str. REL606 putative phage protein (D protein) YP_003045182.1 2100709 R 413997 CDS YP_003045183.1 254162075 8178552 complement(2101501..2102691) 1 NC_012967.1 hypothetical protein 2102691 8178552 ECB_01989 Escherichia coli B str. REL606 hypothetical protein YP_003045183.1 2101501 R 413997 CDS YP_003045184.1 254162076 8176537 2102770..2103081 1 NC_012967.1 hypothetical protein 2103081 8176537 ECB_01990 Escherichia coli B str. REL606 hypothetical protein YP_003045184.1 2102770 D 413997 CDS YP_003045185.1 254162077 8176538 complement(2103106..2103252) 1 NC_012967.1 hypothetical protein 2103252 8176538 ECB_01991 Escherichia coli B str. REL606 hypothetical protein YP_003045185.1 2103106 R 413997 CDS YP_003045186.1 254162078 8176539 2103734..2103949 1 NC_012967.1 hypothetical protein 2103949 8176539 ECB_01992 Escherichia coli B str. REL606 hypothetical protein YP_003045186.1 2103734 D 413997 CDS YP_003045187.1 254162079 8176540 2103921..2105039 1 NC_012967.1 hypothetical protein 2105039 8176540 ECB_01993 Escherichia coli B str. REL606 hypothetical protein YP_003045187.1 2103921 D 413997 CDS YP_003045188.1 254162080 8178553 complement(2105251..2108013) 1 NC_012967.1 hypothetical protein 2108013 8178553 ECB_01994 Escherichia coli B str. REL606 hypothetical protein YP_003045188.1 2105251 R 413997 CDS YP_003045189.1 254162081 8176541 complement(2108120..2108650) 1 NC_012967.1 hypothetical protein 2108650 8176541 ECB_01995 Escherichia coli B str. REL606 hypothetical protein YP_003045189.1 2108120 R 413997 CDS YP_003045190.1 254162082 8176542 complement(2108643..2109512) 1 NC_012967.1 baseplate assembly protein J 2109512 8176542 ECB_01996 Escherichia coli B str. REL606 baseplate assembly protein J YP_003045190.1 2108643 R 413997 CDS YP_003045191.1 254162083 8176543 complement(2109556..2109903) 1 NC_012967.1 baseplate assembly protein W 2109903 8176543 ECB_01997 Escherichia coli B str. REL606 baseplate assembly protein W YP_003045191.1 2109556 R 413997 CDS YP_003045192.1 254162084 8176544 complement(2109900..2110553) 1 NC_012967.1 hypothetical protein 2110553 8176544 ECB_01998 Escherichia coli B str. REL606 hypothetical protein YP_003045192.1 2109900 R 413997 CDS YP_003045193.1 254162085 8178554 2110619..2111404 1 NC_012967.1 hypothetical protein 2111404 8178554 ECB_01999 Escherichia coli B str. REL606 hypothetical protein YP_003045193.1 2110619 D 413997 CDS YP_003045194.1 254162086 8176545 2111440..2112390 1 NC_012967.1 bacteriophage capsid portal protein 2112390 8176545 ECB_02000 Escherichia coli B str. REL606 bacteriophage capsid portal protein YP_003045194.1 2111440 D 413997 CDS YP_003045195.1 254162087 8176546 complement(2112706..2114673) 1 NC_012967.1 hypothetical protein 2114673 8176546 ECB_02001 Escherichia coli B str. REL606 hypothetical protein YP_003045195.1 2112706 R 413997 CDS YP_003045196.1 254162088 8176547 complement(2114673..2115038) 1 NC_012967.1 hypothetical protein 2115038 8176547 ECB_02002 Escherichia coli B str. REL606 hypothetical protein YP_003045196.1 2114673 R 413997 CDS YP_003045197.1 254162089 8179102 complement(2115174..2116391) 1 NC_012967.1 hypothetical protein 2116391 8179102 ECB_02003 Escherichia coli B str. REL606 hypothetical protein YP_003045197.1 2115174 R 413997 CDS YP_003045198.1 254162090 8176548 complement(2116486..2118777) 1 NC_012967.1 Replication gene A protein 2118777 8176548 ECB_02004 Escherichia coli B str. REL606 Replication gene A protein YP_003045198.1 2116486 R 413997 CDS YP_003045199.1 254162091 8179103 complement(2118758..2119033) 1 NC_012967.1 hypothetical protein 2119033 8179103 ECB_02005 Escherichia coli B str. REL606 hypothetical protein YP_003045199.1 2118758 R 413997 CDS YP_003045200.1 254162092 8176549 complement(2119030..2119254) 1 NC_012967.1 hypothetical protein 2119254 8176549 ECB_02006 Escherichia coli B str. REL606 hypothetical protein YP_003045200.1 2119030 R 413997 CDS YP_003045201.1 254162093 8176550 complement(2119257..2119559) 1 NC_012967.1 hypothetical protein 2119559 8176550 ECB_02007 Escherichia coli B str. REL606 hypothetical protein YP_003045201.1 2119257 R 413997 CDS YP_003045202.1 254162094 8179104 complement(2119556..2119780) 1 NC_012967.1 hypothetical protein 2119780 8179104 ECB_02008 Escherichia coli B str. REL606 hypothetical protein YP_003045202.1 2119556 R 413997 CDS YP_003045203.1 254162095 8176551 complement(2119844..2120335) 1 NC_012967.1 hypothetical protein 2120335 8176551 ECB_02009 Escherichia coli B str. REL606 hypothetical protein YP_003045203.1 2119844 R 413997 CDS YP_003045204.1 254162096 8176552 complement(2120522..2120797) 1 NC_012967.1 bacteriophage P2 Cox-like protein 2120797 8176552 ECB_02010 Escherichia coli B str. REL606 bacteriophage P2 Cox-like protein YP_003045204.1 2120522 R 413997 CDS YP_003045205.1 254162097 8176553 2120847..2121218 1 NC_012967.1 bacteriophage P2 C-like protein 2121218 8176553 ECB_02011 Escherichia coli B str. REL606 bacteriophage P2 C-like protein YP_003045205.1 2120847 D 413997 CDS YP_003045206.1 254162098 8176554 2121334..2122347 1 NC_012967.1 integrase 2122347 8176554 ECB_02012 Escherichia coli B str. REL606 integrase YP_003045206.1 2121334 D 413997 CDS YP_003045207.1 254162099 8178555 complement(2122410..2122625) 1 NC_012967.1 hypothetical protein 2122625 8178555 ECB_02013 Escherichia coli B str. REL606 hypothetical protein YP_003045207.1 2122410 R 413997 CDS YP_003045208.1 254162100 8176555 complement(2122613..2122930) 1 NC_012967.1 similar to b2085; hypothetical protein 2122930 yegR 8176555 yegR Escherichia coli B str. REL606 hypothetical protein YP_003045208.1 2122613 R 413997 CDS YP_003045209.1 254162101 8176556 2123335..2124234 1 NC_012967.1 cytosolic protein with phosphatidylglycerol kinase activity; undetermined physiological role; lipid kinase 2124234 yegS 8176556 yegS Escherichia coli B str. REL606 lipid kinase YP_003045209.1 2123335 D 413997 CDS YP_003045210.1 254162102 8176557 complement(2124316..2125089) 1 NC_012967.1 similar to b2089-b2090(b4498); interrupted by IS3 in K-12 MG1655; galactitol utilization operon repressor 2125089 gatR 8176557 gatR Escherichia coli B str. REL606 galactitol utilization operon repressor YP_003045210.1 2124316 R 413997 CDS YP_003045211.1 254162103 8176558 complement(2125195..2126235) 1 NC_012967.1 Zn-dependent; NAD(P)-binding; catalyzes the formation of tagatose-6-phosphate from galactitol-1-phosphate; galactitol-1-phosphate dehydrogenase 2126235 gatD 8176558 gatD Escherichia coli B str. REL606 galactitol-1-phosphate dehydrogenase YP_003045211.1 2125195 R 413997 CDS YP_003045212.1 254162104 8178556 complement(2126283..2127638) 1 NC_012967.1 similar to b2092; PTS system galactitol-specific transporter subunit IIC 2127638 gatC 8178556 gatC Escherichia coli B str. REL606 PTS system galactitol-specific transporter subunit IIC YP_003045212.1 2126283 R 413997 CDS YP_003045213.1 254162105 8176559 complement(2127642..2127926) 1 NC_012967.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system galactitol-specific transporter subunit IIB 2127926 gatB 8176559 gatB Escherichia coli B str. REL606 PTS system galactitol-specific transporter subunit IIB YP_003045213.1 2127642 R 413997 CDS YP_003045214.1 254162106 8176560 complement(2127957..2128409) 1 NC_012967.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system galactitol-specific transporter subunit IIA 2128409 gatA 8176560 gatA Escherichia coli B str. REL606 PTS system galactitol-specific transporter subunit IIA YP_003045214.1 2127957 R 413997 CDS YP_003045215.1 254162107 8176562 2128655..2128930 1 NC_012967.1 IS1 protein InsA 2128930 insA-15 8176562 insA-15 Escherichia coli B str. REL606 IS1 protein InsA YP_003045215.1 2128655 D 413997 CDS YP_003045216.1 254162108 8179105 2128849..2129352 1 NC_012967.1 IS1 protein InsB 2129352 insB-15 8179105 insB-15 Escherichia coli B str. REL606 IS1 protein InsB YP_003045216.1 2128849 D 413997 CDS YP_003045217.1 254162109 8176563 complement(2130487..2131341) 1 NC_012967.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway; tagatose-bisphosphate aldolase 2131341 gatY 8176563 gatY Escherichia coli B str. REL606 tagatose-bisphosphate aldolase YP_003045217.1 2130487 R 413997 CDS YP_003045218.1 254162110 8179106 complement(2131641..2132693) 1 NC_012967.1 catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate; fructose-bisphosphate aldolase 2132693 fbaB 8179106 fbaB Escherichia coli B str. REL606 fructose-bisphosphate aldolase YP_003045218.1 2131641 R 413997 CDS YP_003045219.1 254162111 8176564 2132950..2134227 1 NC_012967.1 similar to b2098; putative nucleoside transporter 2134227 yegT 8176564 yegT Escherichia coli B str. REL606 putative nucleoside transporter YP_003045219.1 2132950 D 413997 CDS YP_003045220.1 254162112 8176565 2134224..2135228 1 NC_012967.1 similar to b2099; putative hydrolase 2135228 yegU 8176565 yegU Escherichia coli B str. REL606 putative hydrolase YP_003045220.1 2134224 D 413997 CDS YP_003045221.1 254162113 8179107 2135225..2136190 1 NC_012967.1 similar to b2100; putative kinase 2136190 yegV 8179107 yegV Escherichia coli B str. REL606 putative kinase YP_003045221.1 2135225 D 413997 CDS YP_003045222.1 254162114 8176566 complement(2136164..2136910) 1 NC_012967.1 similar to b2101; putative DNA-binding transcriptional regulator 2136910 yegW 8176566 yegW Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003045222.1 2136164 R 413997 CDS YP_003045223.1 254162115 8176567 complement(2136962..2137780) 1 NC_012967.1 similar to b2102; putative hydrolase 2137780 yegX 8176567 yegX Escherichia coli B str. REL606 putative hydrolase YP_003045223.1 2136962 R 413997 CDS YP_003045224.1 254162116 8176568 complement(2137845..2138645) 1 NC_012967.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 2138645 thiD 8176568 thiD Escherichia coli B str. REL606 phosphomethylpyrimidine kinase YP_003045224.1 2137845 R 413997 CDS YP_003045225.1 254162117 8176569 complement(2138642..2139430) 1 NC_012967.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase 2139430 thiM 8176569 thiM Escherichia coli B str. REL606 hydroxyethylthiazole kinase YP_003045225.1 2138642 R 413997 CDS YP_003045226.1 254162118 8176570 2139753..2139998 1 NC_012967.1 hypothetical protein 2139998 8176570 ECB_02033 Escherichia coli B str. REL606 hypothetical protein YP_003045226.1 2139753 D 413997 CDS YP_003045227.1 254162119 8176571 2140045..2140476 1 NC_012967.1 hypothetical protein 2140476 8176571 ECB_02034 Escherichia coli B str. REL606 hypothetical protein YP_003045227.1 2140045 D 413997 CDS YP_003045228.1 254162120 8176572 complement(2140580..2141245) 1 NC_012967.1 hypothetical protein 2141245 8176572 ECB_02035 Escherichia coli B str. REL606 hypothetical protein YP_003045228.1 2140580 R 413997 CDS YP_003045229.1 254162121 8176573 complement(2141439..2141702) 1 NC_012967.1 hypothetical protein 2141702 8176573 ECB_02036 Escherichia coli B str. REL606 hypothetical protein YP_003045229.1 2141439 R 413997 CDS YP_003045230.1 254162122 8178557 complement(2141797..2142048) 1 NC_012967.1 hypothetical protein 2142048 8178557 ECB_02037 Escherichia coli B str. REL606 hypothetical protein YP_003045230.1 2141797 R 413997 CDS YP_003045231.1 254162123 8176574 2142385..2142783 1 NC_012967.1 hypothetical protein 2142783 8176574 ECB_02038 Escherichia coli B str. REL606 hypothetical protein YP_003045231.1 2142385 D 413997 CDS YP_003045232.1 254162124 8176575 complement(2142731..2142922) 1 NC_012967.1 hypothetical protein 2142922 8176575 ECB_02039 Escherichia coli B str. REL606 hypothetical protein YP_003045232.1 2142731 R 413997 CDS YP_003045233.1 254162125 8178558 complement(2143079..2143582) 1 NC_012967.1 IS1 protein InsB 2143582 insB-16 8178558 insB-16 Escherichia coli B str. REL606 IS1 protein InsB YP_003045233.1 2143079 R 413997 CDS YP_003045234.1 254162126 8176576 complement(2143501..2143776) 1 NC_012967.1 IS1 protein InsA 2143776 insA-16 8176576 insA-16 Escherichia coli B str. REL606 IS1 protein InsA YP_003045234.1 2143501 R 413997 CDS YP_003045235.1 254162127 8176577 complement(2143805..2143993) 1 NC_012967.1 similar to b2112; hypothetical protein 2143993 yehE 8176577 yehE Escherichia coli B str. REL606 hypothetical protein YP_003045235.1 2143805 R 413997 CDS YP_003045236.1 254162128 8176578 complement(2144256..2145365) 1 NC_012967.1 similar to b2113; putative ATPase 2145365 mrp 8176578 mrp Escherichia coli B str. REL606 putative ATPase YP_003045236.1 2144256 R 413997 CDS YP_003045237.1 254162129 8176579 2145497..2147530 1 NC_012967.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 2147530 metG 8176579 metG Escherichia coli B str. REL606 methionyl-tRNA synthetase YP_003045237.1 2145497 D 413997 CDS YP_003045238.1 254162130 8176580 2147671..2151465 1 NC_012967.1 similar to b2115-b2116-21174(b4499); molybdate metabolism regulator 2151465 molR 8176580 molR Escherichia coli B str. REL606 molybdate metabolism regulator YP_003045238.1 2147671 D 413997 CDS YP_003045239.1 254162131 8176581 2151475..2155107 1 NC_012967.1 similar to b2118; hypothetical protein 2155107 yehI 8176581 yehI Escherichia coli B str. REL606 hypothetical protein YP_003045239.1 2151475 D 413997 CDS YP_003045240.1 254162132 8179108 2155168..2155485 1 NC_012967.1 similar to b4541; hypothetical protein 2155485 yehK 8179108 yehK Escherichia coli B str. REL606 hypothetical protein YP_003045240.1 2155168 D 413997 CDS YP_003045241.1 254162133 8176582 2155792..2156880 1 NC_012967.1 similar to b2119; putative transporter subunit ATP-binding protein of ABC superfamily 2156880 yehL 8176582 yehL Escherichia coli B str. REL606 putative transporter subunit ATP-binding protein of ABC superfamily YP_003045241.1 2155792 D 413997 CDS YP_003045242.1 254162134 8176583 2156891..2159170 1 NC_012967.1 similar to b2120; hypothetical protein 2159170 yehM 8176583 yehM Escherichia coli B str. REL606 hypothetical protein YP_003045242.1 2156891 D 413997 CDS YP_003045243.1 254162135 8176584 2159163..2160299 1 NC_012967.1 similar to b2121; hypothetical protein 2160299 yehP 8176584 yehP Escherichia coli B str. REL606 hypothetical protein YP_003045243.1 2159163 D 413997 CDS YP_003045244.1 254162136 8176585 2160296..2162296 1 NC_012967.1 similar to b2122; hypothetical protein 2162296 yehQ 8176585 yehQ Escherichia coli B str. REL606 hypothetical protein YP_003045244.1 2160296 D 413997 CDS YP_003045245.1 254162137 8176586 2162421..2162882 1 NC_012967.1 similar to b2123; hypothetical protein 2162882 yehR 8176586 yehR Escherichia coli B str. REL606 hypothetical protein YP_003045245.1 2162421 D 413997 CDS YP_003045246.1 254162138 8178559 complement(2162923..2163393) 1 NC_012967.1 similar to b2124; hypothetical protein 2163393 yehS 8178559 yehS Escherichia coli B str. REL606 hypothetical protein YP_003045246.1 2162923 R 413997 CDS YP_003045247.1 254162139 8178560 complement(2163440..2164159) 1 NC_012967.1 unknown function; when overproduced it confers drug-resistance; putative two-component response-regulatory protein YehT 2164159 yehT 8178560 yehT Escherichia coli B str. REL606 putative two-component response-regulatory protein YehT YP_003045247.1 2163440 R 413997 CDS YP_003045248.1 254162140 8176587 complement(2164156..2165841) 1 NC_012967.1 similar to b2126; putative sensory kinase in two-component system with YehT 2165841 yehU 8176587 yehU Escherichia coli B str. REL606 putative sensory kinase in two-component system with YehT YP_003045248.1 2164156 R 413997 CDS YP_003045249.1 254162141 8179109 2166063..2166794 1 NC_012967.1 similar to b2127; DNA-binding transcriptional regulator 2166794 yehV 8179109 yehV Escherichia coli B str. REL606 DNA-binding transcriptional regulator YP_003045249.1 2166063 D 413997 CDS YP_003045250.1 254162142 8176588 2166854..2166961 1 NC_012967.1 similar to b4542; hypothetical protein 2166961 8176588 ECB_02057 Escherichia coli B str. REL606 hypothetical protein YP_003045250.1 2166854 D 413997 CDS YP_003045251.1 254162143 8176589 complement(2166942..2167673) 1 NC_012967.1 similar to b2128; putative transporter subunit membrane component of ABC superfamily 2167673 yehW 8176589 yehW Escherichia coli B str. REL606 putative transporter subunit membrane component of ABC superfamily YP_003045251.1 2166942 R 413997 CDS YP_003045252.1 254162144 8176590 complement(2167678..2168604) 1 NC_012967.1 similar to b2129; putative transporter subunit ATP-binding protein of ABC superfamily 2168604 yehX 8176590 yehX Escherichia coli B str. REL606 putative transporter subunit ATP-binding protein of ABC superfamily YP_003045252.1 2167678 R 413997 CDS YP_003045253.1 254162145 8176591 complement(2168597..2169754) 1 NC_012967.1 similar to b2130; putative transporter subunit membrane component of ABC superfamily 2169754 yehY 8176591 yehY Escherichia coli B str. REL606 putative transporter subunit membrane component of ABC superfamily YP_003045253.1 2168597 R 413997 CDS YP_003045254.1 254162146 8176592 complement(2169761..2170678) 1 NC_012967.1 similar to b2131; putative transporter subunit periplasmic-binding component of ABC superfamily 2170678 yehZ 8176592 yehZ Escherichia coli B str. REL606 putative transporter subunit periplasmic-binding component of ABC superfamily YP_003045254.1 2169761 R 413997 CDS YP_003045255.1 254162147 8176593 complement(2170930..2173227) 1 NC_012967.1 similar to b2132; beta-D-glucoside glucohydrolase 2173227 bglX 8176593 bglX Escherichia coli B str. REL606 beta-D-glucoside glucohydrolase YP_003045255.1 2170930 R 413997 CDS YP_003045256.1 254162148 8176594 2173423..2175138 1 NC_012967.1 component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent; D-lactate dehydrogenase 2175138 dld 8176594 dld Escherichia coli B str. REL606 D-lactate dehydrogenase YP_003045256.1 2173423 D 413997 CDS YP_003045257.1 254162149 8176595 complement(2175176..2176108) 1 NC_012967.1 specifically hydrolyze the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi; Penicillin-binding protein 7; D-alanyl-D-alanine endopeptidase 2176108 pbpG 8176595 pbpG Escherichia coli B str. REL606 D-alanyl-D-alanine endopeptidase YP_003045257.1 2175176 R 413997 CDS YP_003045258.1 254162150 8179110 complement(2176282..2176869) 1 NC_012967.1 similar to b2135; putative inner membrane protein 2176869 yohC 8179110 yohC Escherichia coli B str. REL606 putative inner membrane protein YP_003045258.1 2176282 R 413997 CDS YP_003045259.1 254162151 8176596 2177039..2177617 1 NC_012967.1 similar to b2136; inner membrane protein 2177617 yohD 8176596 yohD Escherichia coli B str. REL606 inner membrane protein YP_003045259.1 2177039 D 413997 CDS YP_003045260.1 254162152 8176597 complement(2177747..2178508) 1 NC_012967.1 similar to b2137; acetoin dehydrogenase 2178508 yohF 8176597 yohF Escherichia coli B str. REL606 acetoin dehydrogenase YP_003045260.1 2177747 R 413997 CDS YP_003045261.1 254162153 8176598 complement(2178561..2179925) 1 NC_012967.1 may be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug resistance outer membrane protein MdtQ 2179925 yohGH 8176598 yohGH Escherichia coli B str. REL606 multidrug resistance outer membrane protein MdtQ YP_003045261.1 2178561 R 413997 CDS YP_003045262.1 254162154 8176599 complement(2180677..2181624) 1 NC_012967.1 similar to b2140; tRNA-dihydrouridine synthase C 2181624 yohI 8176599 yohI Escherichia coli B str. REL606 tRNA-dihydrouridine synthase C YP_003045262.1 2180677 R 413997 CDS YP_003045263.1 254162155 8176600 2181862..2182260 1 NC_012967.1 similar to b2141; hypothetical protein 2182260 yohJ 8176600 yohJ Escherichia coli B str. REL606 hypothetical protein YP_003045263.1 2181862 D 413997 CDS YP_003045264.1 254162156 8176601 2182257..2182952 1 NC_012967.1 similar to b2142; hypothetical protein 2182952 yohK 8176601 yohK Escherichia coli B str. REL606 hypothetical protein YP_003045264.1 2182257 D 413997 CDS YP_003045265.1 254162157 8176602 2183082..2183966 1 NC_012967.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 2183966 cdd 8176602 cdd Escherichia coli B str. REL606 cytidine deaminase YP_003045265.1 2183082 D 413997 CDS YP_003045266.1 254162158 8176603 2184116..2184835 1 NC_012967.1 similar to b2144; hypothetical protein 2184835 sanA 8176603 sanA Escherichia coli B str. REL606 hypothetical protein YP_003045266.1 2184116 D 413997 CDS YP_003045267.1 254162159 8176604 2184838..2185077 1 NC_012967.1 similar to b2145; putative inner membrane protein 2185077 yeiS 8176604 yeiS Escherichia coli B str. REL606 putative inner membrane protein YP_003045267.1 2184838 D 413997 CDS YP_003045268.1 254162160 8179111 2185271..2186509 1 NC_012967.1 function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain; putative oxidoreductase 2186509 yeiT 8179111 yeiT Escherichia coli B str. REL606 putative oxidoreductase YP_003045268.1 2185271 D 413997 CDS YP_003045269.1 254162161 8179112 2186503..2187738 1 NC_012967.1 catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines; dihydropyrimidine dehydrogenase 2187738 yeiA 8179112 yeiA Escherichia coli B str. REL606 dihydropyrimidine dehydrogenase YP_003045269.1 2186503 D 413997 CDS YP_003045270.1 254162162 8176605 complement(2187981..2188991) 1 NC_012967.1 ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex; beta-methylgalactoside transporter inner membrane component 2188991 mglC 8176605 mglC Escherichia coli B str. REL606 beta-methylgalactoside transporter inner membrane component YP_003045270.1 2187981 R 413997 CDS YP_003045271.1 254162163 8176606 complement(2189007..2190527) 1 NC_012967.1 with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains; galactose/methyl galaxtoside transporter ATP-binding protein 2190527 mglA 8176606 mglA Escherichia coli B str. REL606 galactose/methyl galaxtoside transporter ATP-binding protein YP_003045271.1 2189007 R 413997 CDS YP_003045272.1 254162164 8176607 complement(2190588..2191586) 1 NC_012967.1 similar to b2150; methyl-galactoside transporter subunit 2191586 mglB 8176607 mglB Escherichia coli B str. REL606 methyl-galactoside transporter subunit YP_003045272.1 2190588 R 413997 CDS YP_003045273.1 254162165 8176608 complement(2191866..2192906) 1 NC_012967.1 negative regulator of the mglBAC operon for galactose utilization; DNA-binding transcriptional regulator GalS 2192906 galS 8176608 galS Escherichia coli B str. REL606 DNA-binding transcriptional regulator GalS YP_003045273.1 2191866 R 413997 CDS YP_003045274.1 254162166 8176609 complement(2193048..2194205) 1 NC_012967.1 similar to b2152; hypothetical protein 2194205 yeiB 8176609 yeiB Escherichia coli B str. REL606 hypothetical protein YP_003045274.1 2193048 R 413997 CDS YP_003045275.1 254162167 8176610 complement(2194222..2194890) 1 NC_012967.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 2194890 folE 8176610 folE Escherichia coli B str. REL606 GTP cyclohydrolase I YP_003045275.1 2194222 R 413997 CDS YP_003045276.1 254162168 8179113 2195148..2195984 1 NC_012967.1 similar to b2154; putative esterase 2195984 yeiG 8179113 yeiG Escherichia coli B str. REL606 putative esterase YP_003045276.1 2195148 D 413997 CDS YP_003045277.1 254162169 8179114 complement(2196016..2198007) 1 NC_012967.1 Cir; FeuA; CirA; receptor protein for siderophores (colicin IA, IB and V) and microcins (E492, H47, and M); TonB-dependent; able to transport monomers, dimer, and linear trimers of 2,3-dihydorxybenzoylserine; outer membrane protein; colicin I receptor 2198007 cirA 8179114 cirA Escherichia coli B str. REL606 colicin I receptor YP_003045277.1 2196016 R 413997 CDS YP_003045278.1 254162170 8176611 complement(2198301..2199770) 1 NC_012967.1 similar to b2156; lysine transporter 2199770 lysP 8176611 lysP Escherichia coli B str. REL606 lysine transporter YP_003045278.1 2198301 R 413997 CDS YP_003045279.1 254162171 8176612 complement(2199975..2200856) 1 NC_012967.1 similar to b2157; putative DNA-binding transcriptional regulator 2200856 yeiE 8176612 yeiE Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003045279.1 2199975 R 413997 CDS YP_003045280.1 254162172 8176613 2200955..2202004 1 NC_012967.1 similar to b2158; inner membrane protein 2202004 yeiH 8176613 yeiH Escherichia coli B str. REL606 inner membrane protein YP_003045280.1 2200955 D 413997 CDS YP_003045281.1 254162173 8178561 2202078..2202935 1 NC_012967.1 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues; endonuclease IV 2202935 nfo 8178561 nfo Escherichia coli B str. REL606 endonuclease IV YP_003045281.1 2202078 D 413997 CDS YP_003045282.1 254162174 8176614 2202938..2204026 1 NC_012967.1 similar to b2160; hypothetical protein 2204026 yeiI 8176614 yeiI Escherichia coli B str. REL606 hypothetical protein YP_003045282.1 2202938 D 413997 CDS YP_003045283.1 254162175 8176615 complement(2204082..2205332) 1 NC_012967.1 similar to b2161; putative nucleoside transporter 2205332 yeiJ 8176615 yeiJ Escherichia coli B str. REL606 putative nucleoside transporter YP_003045283.1 2204082 R 413997 CDS YP_003045284.1 254162176 8176616 complement(2205432..2206373) 1 NC_012967.1 Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively; ribonucleoside hydrolase 2 2206373 rihB 8176616 rihB Escherichia coli B str. REL606 ribonucleoside hydrolase 2 YP_003045284.1 2205432 R 413997 CDS YP_003045285.1 254162177 8176617 2206542..2207201 1 NC_012967.1 activator of nucleoside metabolism; DNA-binding transcriptional activator YeiL 2207201 yeiL 8176617 yeiL Escherichia coli B str. REL606 DNA-binding transcriptional activator YeiL YP_003045285.1 2206542 D 413997 CDS YP_003045286.1 254162178 8178562 complement(2207272..2208522) 1 NC_012967.1 similar to b2164; putative nucleoside transporter 2208522 yeiM 8178562 yeiM Escherichia coli B str. REL606 putative nucleoside transporter YP_003045286.1 2207272 R 413997 CDS YP_003045287.1 254162179 8178563 complement(2208616..2209554) 1 NC_012967.1 similar to b2165; hypothetical protein 2209554 yeiN 8178563 yeiN Escherichia coli B str. REL606 hypothetical protein YP_003045287.1 2208616 R 413997 CDS YP_003045288.1 254162180 8176618 complement(2209542..2210483) 1 NC_012967.1 similar to b2166; hypothetical protein 2210483 yeiC 8176618 yeiC Escherichia coli B str. REL606 hypothetical protein YP_003045288.1 2209542 R 413997 CDS YP_003045289.1 254162181 8176619 complement(2210907..2212598) 1 NC_012967.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system fructose-specific transporter subunits IIBC 2212598 fruA 8176619 fruA Escherichia coli B str. REL606 PTS system fructose-specific transporter subunits IIBC YP_003045289.1 2210907 R 413997 CDS YP_003045290.1 254162182 8178564 complement(2212615..2213553) 1 NC_012967.1 converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers; 1-phosphofructokinase 2213553 fruK 8178564 fruK Escherichia coli B str. REL606 1-phosphofructokinase YP_003045290.1 2212615 R 413997 CDS YP_003045291.1 254162183 8178565 complement(2213553..2214683) 1 NC_012967.1 phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr; bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein 2214683 fruB 8178565 fruB Escherichia coli B str. REL606 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein YP_003045291.1 2213553 R 413997 CDS YP_003045292.1 254162184 8176620 2215051..2216232 1 NC_012967.1 similar to b2170; lactose/glucose efflux system 2216232 setB 8176620 setB Escherichia coli B str. REL606 lactose/glucose efflux system YP_003045292.1 2215051 D 413997 CDS YP_003045293.1 254162185 8176621 complement(2216229..2216483) 1 NC_012967.1 similar to b4502; hypothetical protein 2216483 yeiW 8176621 yeiW Escherichia coli B str. REL606 hypothetical protein YP_003045293.1 2216229 R 413997 CDS YP_003045294.1 254162186 8176622 2216638..2217210 1 NC_012967.1 Stimulates the peptidyltransferase activity of the 70S ribosome and enhances dipeptide synthesis with N-formylmethionyl-tRNA and puromycin in vitro, suggesting its involvement in the formation of the first peptide bond of a protein; elongation factor P 2217210 yeiP 8176622 yeiP Escherichia coli B str. REL606 elongation factor P YP_003045294.1 2216638 D 413997 CDS YP_003045295.1 254162187 8176623 2217433..2218899 1 NC_012967.1 similar to b2172; putative dehydrogenase, NAD-dependent 2218899 yeiQ 8176623 yeiQ Escherichia coli B str. REL606 putative dehydrogenase, NAD-dependent YP_003045295.1 2217433 D 413997 CDS YP_003045296.1 254162188 8179115 2219017..2220003 1 NC_012967.1 similar to b2173; hypothetical protein 2220003 yeiR 8179115 yeiR Escherichia coli B str. REL606 hypothetical protein YP_003045296.1 2219017 D 413997 CDS YP_003045297.1 254162189 8176624 2220042..2220755 1 NC_012967.1 similar to b2174; undecaprenyl pyrophosphate phosphatase 2220755 yeiU 8176624 yeiU Escherichia coli B str. REL606 undecaprenyl pyrophosphate phosphatase YP_003045297.1 2220042 D 413997 CDS YP_003045298.1 254162190 8176625 2221167..2221733 1 NC_012967.1 by similarity, Spr seems to have peptidase activity; involved in thermoresistance; putative outer membrane lipoprotein 2221733 spr 8176625 spr Escherichia coli B str. REL606 putative outer membrane lipoprotein YP_003045298.1 2221167 D 413997 CDS YP_003045299.1 254162191 8176626 2221914..2223470 1 NC_012967.1 similar to b2176; hypothetical protein 2223470 rtn 8176626 rtn Escherichia coli B str. REL606 hypothetical protein YP_003045299.1 2221914 D 413997 CDS YP_003045300.1 254162192 8176627 2223552..2225366 1 NC_012967.1 similar to b2177; putative oligopeptide transporter subunit 2225366 yejA 8176627 yejA Escherichia coli B str. REL606 putative oligopeptide transporter subunit YP_003045300.1 2223552 D 413997 CDS YP_003045301.1 254162193 8178566 2225367..2226461 1 NC_012967.1 similar to b2178; putative oligopeptide transporter subunit 2226461 yejB 8178566 yejB Escherichia coli B str. REL606 putative oligopeptide transporter subunit YP_003045301.1 2225367 D 413997 CDS YP_003045302.1 254162194 8176628 2226461..2227486 1 NC_012967.1 similar to b2179; putative oligopeptide transporter subunit 2227486 yejE 8176628 yejE Escherichia coli B str. REL606 putative oligopeptide transporter subunit YP_003045302.1 2226461 D 413997 CDS YP_003045303.1 254162195 8176629 2227488..2229077 1 NC_012967.1 similar to b2180; oligopeptide ABC transporter ATP-binding protein 2229077 yejF 8176629 yejF Escherichia coli B str. REL606 oligopeptide ABC transporter ATP-binding protein YP_003045303.1 2227488 D 413997 CDS YP_003045304.1 254162196 8176630 complement(2229081..2229425) 1 NC_012967.1 similar to b2181; hypothetical protein 2229425 yejG 8176630 yejG Escherichia coli B str. REL606 hypothetical protein YP_003045304.1 2229081 R 413997 CDS YP_003045305.1 254162197 8176631 complement(2229758..2230948) 1 NC_012967.1 Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance; bicyclomycin/multidrug efflux system 2230948 bcr 8176631 bcr Escherichia coli B str. REL606 bicyclomycin/multidrug efflux system YP_003045305.1 2229758 R 413997 CDS YP_003045306.1 254162198 8176632 complement(2230976..2231671) 1 NC_012967.1 catalyzes the synthesis pseudouridine from uracil-516 in 16S ribosomal RNA; 16S rRNA pseudouridylate synthase A 2231671 rsuA 8176632 rsuA Escherichia coli B str. REL606 16S rRNA pseudouridylate synthase A YP_003045306.1 2230976 R 413997 CDS YP_003045307.1 254162199 8176633 2231820..2233580 1 NC_012967.1 similar to b2184; putative ATP-dependet helicase 2233580 yejH 8176633 yejH Escherichia coli B str. REL606 putative ATP-dependet helicase YP_003045307.1 2231820 D 413997 CDS YP_003045308.1 254162200 8176634 2233705..2233989 1 NC_012967.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 2233989 rplY 8176634 rplY Escherichia coli B str. REL606 50S ribosomal protein L25 YP_003045308.1 2233705 D 413997 CDS YP_003045309.1 254162201 8178567 complement(2234128..2235135) 1 NC_012967.1 similar to b2186; nucleoid-associated protein NdpA 2235135 yejK 8178567 yejK Escherichia coli B str. REL606 nucleoid-associated protein NdpA YP_003045309.1 2234128 R 413997 CDS YP_003045310.1 254162202 8176635 2235317..2235544 1 NC_012967.1 similar to b2187; hypothetical protein 2235544 yejL 8176635 yejL Escherichia coli B str. REL606 hypothetical protein YP_003045310.1 2235317 D 413997 CDS YP_003045311.1 254162203 8176636 2235564..2237324 1 NC_012967.1 similar to b2188; putative hydrolase, inner membrane 2237324 yejM 8176636 yejM Escherichia coli B str. REL606 putative hydrolase, inner membrane YP_003045311.1 2235564 D 413997 CDS YP_003045312.1 254162204 8176638 complement(2237578..2240088) 1 NC_012967.1 similar to b2190; putative autotransporter outer membrane protein 2240088 yejO 8176638 yejO Escherichia coli B str. REL606 putative autotransporter outer membrane protein YP_003045312.1 2237578 R 413997 CDS YP_003045313.1 254162205 8176639 2240489..2241136 1 NC_012967.1 nitrate/nitrite response regulator NarP; NarP is phosphorylated by NarX and NarQ and can activate fdnG and nitrite or nitrate reductase systems; represses expression of other anaerobic genes; transcriptional regulator NarP 2241136 narP 8176639 narP Escherichia coli B str. REL606 transcriptional regulator NarP YP_003045313.1 2240489 D 413997 CDS YP_003045314.1 254162206 8176640 complement(2241347..2242399) 1 NC_012967.1 similar to b2194; heme lyase, CcmH subunit 2242399 ccmH 8176640 ccmH Escherichia coli B str. REL606 heme lyase, CcmH subunit YP_003045314.1 2241347 R 413997 CDS YP_003045315.1 254162207 8176641 complement(2242396..2242953) 1 NC_012967.1 similar to b2195; periplasmic thioredoxin of cytochrome c-type biogenesis 2242953 ccmG 8176641 ccmG Escherichia coli B str. REL606 periplasmic thioredoxin of cytochrome c-type biogenesis YP_003045315.1 2242396 R 413997 CDS YP_003045316.1 254162208 8179116 complement(2242950..2244893) 1 NC_012967.1 similar to b2196; heme lyase, CcmF subunit 2244893 ccmF 8179116 ccmF Escherichia coli B str. REL606 heme lyase, CcmF subunit YP_003045316.1 2242950 R 413997 CDS YP_003045317.1 254162209 8178568 complement(2244890..2245369) 1 NC_012967.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane; cytochrome c-type biogenesis protein CcmE 2245369 ccmE 8178568 ccmE Escherichia coli B str. REL606 cytochrome c-type biogenesis protein CcmE YP_003045317.1 2244890 R 413997 CDS YP_003045318.1 254162210 8176642 complement(2245366..2245575) 1 NC_012967.1 similar to b2198; cytochrome c biogenesis protein 2245575 ccmD 8176642 ccmD Escherichia coli B str. REL606 cytochrome c biogenesis protein YP_003045318.1 2245366 R 413997 CDS YP_003045319.1 254162211 8176643 complement(2245572..2246309) 1 NC_012967.1 similar to b2199; heme exporter subunit 2246309 ccmC 8176643 ccmC Escherichia coli B str. REL606 heme exporter subunit YP_003045319.1 2245572 R 413997 CDS YP_003045320.1 254162212 8176644 complement(2246351..2247013) 1 NC_012967.1 similar to b2200; heme exporter subunit 2247013 ccmB 8176644 ccmB Escherichia coli B str. REL606 heme exporter subunit YP_003045320.1 2246351 R 413997 CDS YP_003045321.1 254162213 8176645 complement(2247010..2247633) 1 NC_012967.1 ATP-binding protein; required for proper cytochrome c maturation; cytochrome c biogenesis protein CcmA 2247633 ccmA 8176645 ccmA Escherichia coli B str. REL606 cytochrome c biogenesis protein CcmA YP_003045321.1 2247010 R 413997 CDS YP_003045322.1 254162214 8178569 complement(2247646..2248248) 1 NC_012967.1 with NapABDFGH functions as a nitrate reductase; NapC functions as an electron shuttle between NapAB and NapGH or quinone; cytochrome c-type protein NapC 2248248 napC 8178569 napC Escherichia coli B str. REL606 cytochrome c-type protein NapC YP_003045322.1 2247646 R 413997 CDS YP_003045323.1 254162215 8176646 complement(2248258..2248707) 1 NC_012967.1 small subunit of periplasmic nitrate reductase; receives electrons from the membrane-bound NapC and passes them to NapA; citrate reductase cytochrome c-type subunit 2248707 napB 8176646 napB Escherichia coli B str. REL606 citrate reductase cytochrome c-type subunit YP_003045323.1 2248258 R 413997 CDS YP_003045324.1 254162216 8176647 complement(2248704..2249567) 1 NC_012967.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; quinol dehydrogenase membrane component 2249567 napH 8176647 napH Escherichia coli B str. REL606 quinol dehydrogenase membrane component YP_003045324.1 2248704 R 413997 CDS YP_003045325.1 254162217 8176648 complement(2249554..2250249) 1 NC_012967.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway; quinol dehydrogenase periplasmic component 2250249 napG 8176648 napG Escherichia coli B str. REL606 quinol dehydrogenase periplasmic component YP_003045325.1 2249554 R 413997 CDS YP_003045326.1 254162218 8179117 complement(2250256..2252742) 1 NC_012967.1 periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC; nitrate reductase catalytic subunit 2252742 napA 8179117 napA Escherichia coli B str. REL606 nitrate reductase catalytic subunit YP_003045326.1 2250256 R 413997 CDS YP_003045327.1 254162219 8179118 complement(2252739..2253002) 1 NC_012967.1 similar to b2207; assembly protein for periplasmic nitrate reductase 2253002 napD 8179118 napD Escherichia coli B str. REL606 assembly protein for periplasmic nitrate reductase YP_003045327.1 2252739 R 413997 CDS YP_003045328.1 254162220 8176649 complement(2252992..2253486) 1 NC_012967.1 Predicted role in electron transfer to the periplasmic nitrate reductase protein NapA.; ferredoxin-type protein 2253486 napF 8176649 napF Escherichia coli B str. REL606 ferredoxin-type protein YP_003045328.1 2252992 R 413997 CDS YP_003045329.1 254162221 8176650 2253894..2254382 1 NC_012967.1 serine protease inhibitor, inhibits trypsin and other proteases; ecotin 2254382 eco 8176650 eco Escherichia coli B str. REL606 ecotin YP_003045329.1 2253894 D 413997 CDS YP_003045330.1 254162222 8176651 complement(2255212..2256858) 1 NC_012967.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; malate:quinone oxidoreductase 2256858 mqo 8176651 mqo Escherichia coli B str. REL606 malate:quinone oxidoreductase YP_003045330.1 2255212 R 413997 CDS YP_003045331.1 254162223 8176652 complement(2257076..2258719) 1 NC_012967.1 efflux pump for the antibacterial peptide microcin J25; multidrug transporter membrane component/ATP-binding protein 2258719 yojI 8176652 yojI Escherichia coli B str. REL606 multidrug transporter membrane component/ATP-binding protein YP_003045331.1 2257076 R 413997 CDS YP_003045332.1 254162224 8176653 complement(2258795..2259445) 1 NC_012967.1 similar to b2212; oxidative demethylase of N1-methyladenine or N3-methylcytosine DNA lesions 2259445 alkB 8176653 alkB Escherichia coli B str. REL606 oxidative demethylase of N1-methyladenine or N3-methylcytosine DNA lesions YP_003045332.1 2258795 R 413997 CDS YP_003045333.1 254162225 8176654 complement(2259445..2260509) 1 NC_012967.1 similar to b2213; bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase 2260509 ada 8176654 ada Escherichia coli B str. REL606 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase YP_003045333.1 2259445 R 413997 CDS YP_003045334.1 254162226 8178570 complement(2260583..2261638) 1 NC_012967.1 catalyzes the conversion of aminoimidazole ribotide to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine moiety of thiamine; involved in the maintenance and/or assembly of sulfur clusters; periplasmic lipoporotein anchored to the inner membrane; part of the thiamine pyrophosphate biosynthesis pathway; thiamine biosynthesis lipoprotein ApbE 2261638 yojL 8178570 yojL Escherichia coli B str. REL606 thiamine biosynthesis lipoprotein ApbE YP_003045334.1 2260583 R 413997 CDS YP_003045335.1 254162227 8176655 complement(2261750..2262685) 1 NC_012967.1 similar to b2215; outer membrane porin protein C 2262685 ompC 8176655 ompC Escherichia coli B str. REL606 outer membrane porin protein C YP_003045335.1 2261750 R 413997 CDS YP_003045336.1 254162228 8176656 complement(2262755..2263258) 1 NC_012967.1 IS1 protein InsB 2263258 insB-17 8176656 insB-17 Escherichia coli B str. REL606 IS1 protein InsB YP_003045336.1 2262755 R 413997 CDS YP_003045337.1 254162229 8176657 complement(2263177..2263452) 1 NC_012967.1 IS1 protein InsA 2263452 insA-17 8176657 insA-17 Escherichia coli B str. REL606 IS1 protein InsA YP_003045337.1 2263177 R 413997 CDS YP_003045338.1 254162230 8176658 complement(2263727..2266528) 1 NC_012967.1 similar to b2218; hybrid sensory kinase in two-component regulatory system with RcsB and YojN 2266528 rcsC 8176658 rcsC Escherichia coli B str. REL606 hybrid sensory kinase in two-component regulatory system with RcsB and YojN YP_003045338.1 2263727 R 413997 CDS YP_003045339.1 254162231 8179119 2266743..2268569 1 NC_012967.1 with AtoC is a member of a two-component regulatory system involved in the transcriptional regulation of the ato genes for acetoacetate metabolism; sensory histidine kinase AtoS 2268569 atoS 8179119 atoS Escherichia coli B str. REL606 sensory histidine kinase AtoS YP_003045339.1 2266743 D 413997 CDS YP_003045340.1 254162232 8176659 2268566..2269951 1 NC_012967.1 with AtoS is a two-component regulatory system involved in the transcriptional regulation of the ato genes for acetoacetate metabolism; acetoacetate metabolism regulatory protein AtoC 2269951 atoC 8176659 atoC Escherichia coli B str. REL606 acetoacetate metabolism regulatory protein AtoC YP_003045340.1 2268566 D 413997 CDS YP_003045341.1 254162233 8176660 2270147..2270809 1 NC_012967.1 similar to b2221; acetyl-CoA:acetoacetyl-CoA transferase subunit alpha 2270809 atoD 8176660 atoD Escherichia coli B str. REL606 acetyl-CoA:acetoacetyl-CoA transferase subunit alpha YP_003045341.1 2270147 D 413997 CDS YP_003045342.1 254162234 8176661 2270809..2271459 1 NC_012967.1 similar to b2222; acetyl-CoA:acetoacetyl-CoA transferase, subunit beta 2271459 atoA 8176661 atoA Escherichia coli B str. REL606 acetyl-CoA:acetoacetyl-CoA transferase, subunit beta YP_003045342.1 2270809 D 413997 CDS YP_003045343.1 254162235 8176662 2271456..2272778 1 NC_012967.1 similar to b2223; short chain fatty acid transporter 2272778 atoE 8176662 atoE Escherichia coli B str. REL606 short chain fatty acid transporter YP_003045343.1 2271456 D 413997 CDS YP_003045344.1 254162236 8178571 2272809..2273993 1 NC_012967.1 similar to b2224; acetyl-CoA acetyltransferase 2273993 atoB 8178571 atoB Escherichia coli B str. REL606 acetyl-CoA acetyltransferase YP_003045344.1 2272809 D 413997 CDS YP_003045345.1 254162237 8178572 complement(2274067..2274843) 1 NC_012967.1 similar to b2225; hypothetical protein 2274843 yfaP 8178572 yfaP Escherichia coli B str. REL606 hypothetical protein YP_003045345.1 2274067 R 413997 CDS YP_003045346.1 254162238 8176663 complement(2274848..2276497) 1 NC_012967.1 similar to b2226; hypothetical protein 2276497 yfaQ 8176663 yfaQ Escherichia coli B str. REL606 hypothetical protein YP_003045346.1 2274848 R 413997 CDS YP_003045347.1 254162239 8176664 complement(2276498..2281102) 1 NC_012967.1 similar to b2227-b2228(b4500); pseudo in K-12 MG1655; hypothetical protein 2281102 yfaS 8176664 yfaS Escherichia coli B str. REL606 hypothetical protein YP_003045347.1 2276498 R 413997 CDS YP_003045348.1 254162240 8176665 complement(2281036..2281659) 1 NC_012967.1 similar to b2229; hypothetical protein 2281659 yfaT 8176665 yfaT Escherichia coli B str. REL606 hypothetical protein YP_003045348.1 2281036 R 413997 CDS YP_003045349.1 254162241 8179120 complement(2281656..2283344) 1 NC_012967.1 similar to b2230; hypothetical protein 2283344 yfaA 8179120 yfaA Escherichia coli B str. REL606 hypothetical protein YP_003045349.1 2281656 R 413997 CDS YP_003045350.1 254162242 8176666 complement(2283493..2286120) 1 NC_012967.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 2286120 gyrA 8176666 gyrA Escherichia coli B str. REL606 DNA gyrase subunit A YP_003045350.1 2283493 R 413997 CDS YP_003045351.1 254162243 8176667 2286267..2286989 1 NC_012967.1 Involved in ubiquinone biosynthesis; 3-demethylubiquinone-9 3-methyltransferase 2286989 ubiG 8176667 ubiG Escherichia coli B str. REL606 3-demethylubiquinone-9 3-methyltransferase YP_003045351.1 2286267 D 413997 CDS YP_003045352.1 254162244 8176668 complement(2287117..2290869) 1 NC_012967.1 similar to b2233; adhesin 2290869 yfaL 8176668 yfaL Escherichia coli B str. REL606 adhesin YP_003045352.1 2287117 R 413997 CDS YP_003045353.1 254162245 8176669 2291565..2293850 1 NC_012967.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 2293850 nrdA 8176669 nrdA Escherichia coli B str. REL606 ribonucleotide-diphosphate reductase subunit alpha YP_003045353.1 2291565 D 413997 CDS YP_003045354.1 254162246 8179121 2294092..2295222 1 NC_012967.1 B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA; ribonucleotide-diphosphate reductase subunit beta 2295222 nrdB 8179121 nrdB Escherichia coli B str. REL606 ribonucleotide-diphosphate reductase subunit beta YP_003045354.1 2294092 D 413997 CDS YP_003045355.1 254162247 8176670 2295222..2295476 1 NC_012967.1 plays a role in maintenance and possibly the biosynthesis of diferric-tyrosyl radical cofactor, essential for nucleotide reduction catalyzed by ribonucleotide reductases; 2Fe-2S ferredoxin YfaE 2295476 yfaE 8176670 yfaE Escherichia coli B str. REL606 2Fe-2S ferredoxin YfaE YP_003045355.1 2295222 D 413997 CDS YP_003045356.1 254162248 8178573 complement(2295530..2296180) 1 NC_012967.1 similar to b2237; hypothetical protein 2296180 inaA 8178573 inaA Escherichia coli B str. REL606 hypothetical protein YP_003045356.1 2295530 R 413997 CDS YP_003045357.1 254162249 8178574 2296395..2296601 1 NC_012967.1 similar to b2238; hypothetical protein 2296601 yfaH 8178574 yfaH Escherichia coli B str. REL606 hypothetical protein YP_003045357.1 2296395 D 413997 CDS YP_003045358.1 254162250 8176671 complement(2296643..2297719) 1 NC_012967.1 hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic; glycerophosphodiester phosphodiesterase 2297719 glpQ 8176671 glpQ Escherichia coli B str. REL606 glycerophosphodiester phosphodiesterase YP_003045358.1 2296643 R 413997 CDS YP_003045359.1 254162251 8176672 complement(2297724..2299082) 1 NC_012967.1 catalyzes the uptake of glycerol-3-phosphate into the cell with the simultaneous export of inorganic phosphate from the cell; sn-glycerol-3-phosphate transporter 2299082 glpT 8176672 glpT Escherichia coli B str. REL606 sn-glycerol-3-phosphate transporter YP_003045359.1 2297724 R 413997 CDS YP_003045360.1 254162252 8176673 2299355..2300983 1 NC_012967.1 anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor; sn-glycerol-3-phosphate dehydrogenase subunit A 2300983 glpA 8176673 glpA Escherichia coli B str. REL606 sn-glycerol-3-phosphate dehydrogenase subunit A YP_003045360.1 2299355 D 413997 CDS YP_003045361.1 254162253 8176674 2300973..2302232 1 NC_012967.1 sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters; anaerobic glycerol-3-phosphate dehydrogenase subunit B 2302232 glpB 8176674 glpB Escherichia coli B str. REL606 anaerobic glycerol-3-phosphate dehydrogenase subunit B YP_003045361.1 2300973 D 413997 CDS YP_003045362.1 254162254 8176675 2302229..2303419 1 NC_012967.1 anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate; sn-glycerol-3-phosphate dehydrogenase subunit C 2303419 glpC 8176675 glpC Escherichia coli B str. REL606 sn-glycerol-3-phosphate dehydrogenase subunit C YP_003045362.1 2302229 D 413997 CDS YP_003045363.1 254162255 8176676 2303612..2304514 1 NC_012967.1 similar to b2244; hypothetical protein 2304514 yfaD 8176676 yfaD Escherichia coli B str. REL606 hypothetical protein YP_003045363.1 2303612 D 413997 CDS YP_003045364.1 254162256 8176677 complement(2304555..2305358) 1 NC_012967.1 similar to b2245; putative aldolase 2305358 yfaU 8176677 yfaU Escherichia coli B str. REL606 putative aldolase YP_003045364.1 2304555 R 413997 CDS YP_003045365.1 254162257 8176678 complement(2305376..2306665) 1 NC_012967.1 similar to b2246; putative transporter 2306665 yfaV 8176678 yfaV Escherichia coli B str. REL606 putative transporter YP_003045365.1 2305376 R 413997 CDS YP_003045366.1 254162258 8179122 complement(2306722..2307939) 1 NC_012967.1 similar to b2247; putative enolase 2307939 yfaW 8179122 yfaW Escherichia coli B str. REL606 putative enolase YP_003045366.1 2306722 R 413997 CDS YP_003045367.1 254162259 8179123 complement(2307942..2308724) 1 NC_012967.1 similar to b2248; putative DNA-binding transcriptional regulator 2308724 yfaX 8179123 yfaX Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003045367.1 2307942 R 413997 CDS YP_003045368.1 254162260 8176679 complement(2308944..2310146) 1 NC_012967.1 similar to b2249; competence damage-inducible protein A 2310146 yfaY 8176679 yfaY Escherichia coli B str. REL606 competence damage-inducible protein A YP_003045368.1 2308944 R 413997 CDS YP_003045369.1 254162261 8176680 complement(2310246..2310788) 1 NC_012967.1 similar to b2250; putative outer membrane porin protein 2310788 yfaZ 8176680 yfaZ Escherichia coli B str. REL606 putative outer membrane porin protein YP_003045369.1 2310246 R 413997 CDS YP_003045370.1 254162262 8176681 2311067..2311492 1 NC_012967.1 similar to b2251; putative NUDIX hydrolase 2311492 yfaO 8176681 yfaO Escherichia coli B str. REL606 putative NUDIX hydrolase YP_003045370.1 2311067 D 413997 CDS YP_003045371.1 254162263 8176682 complement(2311531..2312133) 1 NC_012967.1 similar to b2252; hypothetical protein 2312133 ais 8176682 ais Escherichia coli B str. REL606 hypothetical protein YP_003045371.1 2311531 R 413997 CDS YP_003045372.1 254162264 8176683 2312423..2313580 1 NC_012967.1 catalyzes the conversion of UDP-4-keto-arabinose to UDP-4-amino-4-deoxy-L-arabinose; UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase 2313580 yfbE 8176683 yfbE Escherichia coli B str. REL606 UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase YP_003045372.1 2312423 D 413997 CDS YP_003045373.1 254162265 8176684 2313584..2314552 1 NC_012967.1 catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate; undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase 2314552 yfbF 8176684 yfbF Escherichia coli B str. REL606 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase YP_003045373.1 2313584 D 413997 CDS YP_003045374.1 254162266 8176685 2314552..2316534 1 NC_012967.1 Bifunctional polymyxin resistance arnA protein; catalyzes the decarboxylation of UDP-glucuronic acid to UDP-4-keto-arabinose and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose to form UDP-L-4-formamido-arabinose; active in certain mutant strains; bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase 2316534 yfbG 8176685 yfbG Escherichia coli B str. REL606 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase YP_003045374.1 2314552 D 413997 CDS YP_003045375.1 254162267 8176686 2316531..2317421 1 NC_012967.1 similar to b2256; hypothetical protein 2317421 yfbH 8176686 yfbH Escherichia coli B str. REL606 hypothetical protein YP_003045375.1 2316531 D 413997 CDS YP_003045376.1 254162268 8176687 2317421..2319073 1 NC_012967.1 catalyzes the addition of 4-amino-4-deoxy-L-arabinose to lipid A; 4-amino-4-deoxy-L-arabinose transferase 2319073 arnT 8176687 arnT Escherichia coli B str. REL606 4-amino-4-deoxy-L-arabinose transferase YP_003045376.1 2317421 D 413997 CDS YP_003045377.1 254162269 8179124 2319070..2319405 1 NC_012967.1 similar to b4544; hypothetical protein 2319405 yfbW 8179124 yfbW Escherichia coli B str. REL606 hypothetical protein YP_003045377.1 2319070 D 413997 CDS YP_003045378.1 254162270 8176688 2319405..2319791 1 NC_012967.1 similar to b2258; hypothetical protein 2319791 yfbJ 8176688 yfbJ Escherichia coli B str. REL606 hypothetical protein YP_003045378.1 2319405 D 413997 CDS YP_003045379.1 254162271 8176689 complement(2319785..2320051) 1 NC_012967.1 similar to b2259; polymyxin resistance protein B 2320051 pmrD 8176689 pmrD Escherichia coli B str. REL606 polymyxin resistance protein B YP_003045379.1 2319785 R 413997 CDS YP_003045380.1 254162272 8178575 complement(2320161..2321516) 1 NC_012967.1 similar to b2260; O-succinylbenzoic acid--CoA ligase 2321516 menE 8178575 menE Escherichia coli B str. REL606 O-succinylbenzoic acid--CoA ligase YP_003045380.1 2320161 R 413997 CDS YP_003045381.1 254162273 8176690 complement(2321513..2322475) 1 NC_012967.1 catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase 2322475 menC 8176690 menC Escherichia coli B str. REL606 O-succinylbenzoate synthase YP_003045381.1 2321513 R 413997 CDS YP_003045382.1 254162274 8176691 complement(2322475..2323332) 1 NC_012967.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase 2323332 menB 8176691 menB Escherichia coli B str. REL606 naphthoate synthase YP_003045382.1 2322475 R 413997 CDS YP_003045383.1 254162275 8176692 complement(2323347..2324105) 1 NC_012967.1 catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; acyl-CoA thioester hydrolase YfbB 2324105 yfbB 8176692 yfbB Escherichia coli B str. REL606 acyl-CoA thioester hydrolase YfbB YP_003045383.1 2323347 R 413997 CDS YP_003045384.1 254162276 8176693 complement(2324102..2325772) 1 NC_012967.1 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase 2325772 menD 8176693 menD Escherichia coli B str. REL606 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase YP_003045384.1 2324102 R 413997 CDS YP_003045385.1 254162277 8176694 complement(2325861..2327156) 1 NC_012967.1 similar to b2265; menaquinone-specific isochorismate synthase 2327156 menF 8176694 menF Escherichia coli B str. REL606 menaquinone-specific isochorismate synthase YP_003045385.1 2325861 R 413997 CDS YP_003045386.1 254162278 8176695 complement(2327235..2327540) 1 NC_012967.1 similar to b2266; hypothetical protein 2327540 elaB 8176695 elaB Escherichia coli B str. REL606 hypothetical protein YP_003045386.1 2327235 R 413997 CDS YP_003045387.1 254162279 8176696 complement(2327595..2328056) 1 NC_012967.1 similar to b2267; hypothetical protein 2328056 elaA 8176696 elaA Escherichia coli B str. REL606 hypothetical protein YP_003045387.1 2327595 R 413997 CDS YP_003045388.1 254162280 8176697 2328121..2329038 1 NC_012967.1 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 2329038 elaC 8176697 elaC Escherichia coli B str. REL606 ribonuclease Z YP_003045388.1 2328121 D 413997 CDS YP_003045389.1 254162281 8176698 2329226..2330437 1 NC_012967.1 ElaD; specific cysteine protease which targets ubiquitin and ubiquitin-like proteins covalently bound to target proteins; SseL in Salmonella is required for macrophage killing and virulence, and it is secreted by the salmonella pathogenicity island 2 type III secretion system; deubiquitinase 2330437 elaD 8176698 elaD Escherichia coli B str. REL606 deubiquitinase YP_003045389.1 2329226 D 413997 CDS YP_003045390.1 254162282 8178577 2331557..2332060 1 NC_012967.1 similar to b2272; hypothetical protein 2332060 yfbM 8178577 yfbM Escherichia coli B str. REL606 hypothetical protein YP_003045390.1 2331557 D 413997 CDS YP_003045391.1 254162283 8176699 2332147..2332668 1 NC_012967.1 putative ISRSO11-transposase orfA protein 2332668 8176699 ECB_02199 Escherichia coli B str. REL606 putative ISRSO11-transposase orfA protein YP_003045391.1 2332147 D 413997 CDS YP_003045392.1 254162284 8176700 2332665..2333504 1 NC_012967.1 YadA protein 2333504 8176700 ECB_02200 Escherichia coli B str. REL606 YadA protein YP_003045392.1 2332665 D 413997 CDS YP_003045393.1 254162285 8176701 complement(2333572..2334849) 1 NC_012967.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit N 2334849 nuoN 8176701 nuoN Escherichia coli B str. REL606 NADH dehydrogenase subunit N YP_003045393.1 2333572 R 413997 CDS YP_003045394.1 254162286 8179125 complement(2335036..2336565) 1 NC_012967.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit M 2336565 nuoM 8179125 nuoM Escherichia coli B str. REL606 NADH dehydrogenase subunit M YP_003045394.1 2335036 R 413997 CDS YP_003045395.1 254162287 8176702 complement(2336796..2338637) 1 NC_012967.1 Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit L 2338637 nuoL 8176702 nuoL Escherichia coli B str. REL606 NADH dehydrogenase subunit L YP_003045395.1 2336796 R 413997 CDS YP_003045396.1 254162288 8176703 complement(2338634..2338936) 1 NC_012967.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit K 2338936 nuoK 8176703 nuoK Escherichia coli B str. REL606 NADH dehydrogenase subunit K YP_003045396.1 2338634 R 413997 CDS YP_003045397.1 254162289 8176704 complement(2338933..2339487) 1 NC_012967.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit J 2339487 nuoJ 8176704 nuoJ Escherichia coli B str. REL606 NADH dehydrogenase subunit J YP_003045397.1 2338933 R 413997 CDS YP_003045398.1 254162290 8176705 complement(2339499..2340041) 1 NC_012967.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I 2340041 nuoI 8176705 nuoI Escherichia coli B str. REL606 NADH dehydrogenase subunit I YP_003045398.1 2339499 R 413997 CDS YP_003045399.1 254162291 8176706 complement(2340056..2341033) 1 NC_012967.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit H 2341033 nuoH 8176706 nuoH Escherichia coli B str. REL606 NADH dehydrogenase subunit H YP_003045399.1 2340056 R 413997 CDS YP_003045400.1 254162292 8176707 complement(2341030..2343762) 1 NC_012967.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit G 2343762 nuoG 8176707 nuoG Escherichia coli B str. REL606 NADH dehydrogenase subunit G YP_003045400.1 2341030 R 413997 CDS YP_003045401.1 254162293 8176708 complement(2343809..2345146) 1 NC_012967.1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase; NADH dehydrogenase I subunit F 2345146 nuoF 8176708 nuoF Escherichia coli B str. REL606 NADH dehydrogenase I subunit F YP_003045401.1 2343809 R 413997 CDS YP_003045402.1 254162294 8176709 complement(2345143..2345643) 1 NC_012967.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit E 2345643 nuoE 8176709 nuoE Escherichia coli B str. REL606 NADH dehydrogenase subunit E YP_003045402.1 2345143 R 413997 CDS YP_003045403.1 254162295 8178578 complement(2345646..2347448) 1 NC_012967.1 NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms; bifunctional NADH:ubiquinone oxidoreductase subunit C/D 2347448 nuoC 8178578 nuoC Escherichia coli B str. REL606 bifunctional NADH:ubiquinone oxidoreductase subunit C/D YP_003045403.1 2345646 R 413997 CDS YP_003045404.1 254162296 8176710 complement(2347542..2348204) 1 NC_012967.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B 2348204 nuoB 8176710 nuoB Escherichia coli B str. REL606 NADH dehydrogenase subunit B YP_003045404.1 2347542 R 413997 CDS YP_003045405.1 254162297 8176711 complement(2348220..2348663) 1 NC_012967.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit A 2348663 nuoA 8176711 nuoA Escherichia coli B str. REL606 NADH dehydrogenase subunit A YP_003045405.1 2348220 R 413997 CDS YP_003045406.1 254162298 8176712 complement(2349294..2350232) 1 NC_012967.1 DNA-binding transcriptional repressor of flagellar, motility and chemotaxis genes; similar to b2289; DNA-binding transcriptional repressor protein 2350232 lrhA 8176712 lrhA Escherichia coli B str. REL606 DNA-binding transcriptional repressor protein YP_003045406.1 2349294 R 413997 CDS YP_003045407.1 254162299 8176713 2351152..2352369 1 NC_012967.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase AlaT 2352369 yfbQ 8176713 yfbQ Escherichia coli B str. REL606 aminotransferase AlaT YP_003045407.1 2351152 D 413997 CDS YP_003045408.1 254162300 8178579 2352453..2353052 1 NC_012967.1 similar to b2291; hypothetical protein 2353052 yfbR 8178579 yfbR Escherichia coli B str. REL606 hypothetical protein YP_003045408.1 2352453 D 413997 CDS YP_003045409.1 254162301 8178580 complement(2353111..2354943) 1 NC_012967.1 similar to b2292; putative transporter 2354943 yfbS 8178580 yfbS Escherichia coli B str. REL606 putative transporter YP_003045409.1 2353111 R 413997 CDS YP_003045410.1 254162302 8176714 complement(2355030..2355680) 1 NC_012967.1 similar to b2293; putative phosphatase 2355680 yfbT 8176714 yfbT Escherichia coli B str. REL606 putative phosphatase YP_003045410.1 2355030 R 413997 CDS YP_003045411.1 254162303 8176715 complement(2355691..2356185) 1 NC_012967.1 similar to b2294; hypothetical protein 2356185 yfbU 8176715 yfbU Escherichia coli B str. REL606 hypothetical protein YP_003045411.1 2355691 R 413997 CDS YP_003045412.1 254162304 8176716 complement(2356268..2356723) 1 NC_012967.1 similar to b2295; hypothetical protein 2356723 yfbV 8176716 yfbV Escherichia coli B str. REL606 hypothetical protein YP_003045412.1 2356268 R 413997 CDS YP_003045413.1 254162305 8176717 2357062..2358264 1 NC_012967.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 2358264 ackA 8176717 ackA Escherichia coli B str. REL606 acetate kinase YP_003045413.1 2357062 D 413997 CDS YP_003045414.1 254162306 8178581 2358339..2360483 1 NC_012967.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 2360483 pta 8178581 pta Escherichia coli B str. REL606 phosphate acetyltransferase YP_003045414.1 2358339 D 413997 CDS YP_003045415.1 254162307 8178582 2360673..2362193 1 NC_012967.1 similar to b2298; hypothetical protein 2362193 yfcC 8178582 yfcC Escherichia coli B str. REL606 hypothetical protein YP_003045415.1 2360673 D 413997 CDS YP_003045416.1 254162308 8176718 complement(2362226..2362768) 1 NC_012967.1 similar to b2299; putative NUDIX hydrolase 2362768 yfcD 8176718 yfcD Escherichia coli B str. REL606 putative NUDIX hydrolase YP_003045416.1 2362226 R 413997 CDS YP_003045417.1 254162309 8176719 complement(2362826..2363380) 1 NC_012967.1 similar to b2300; phosphodiesterase 2363380 yfcE 8176719 yfcE Escherichia coli B str. REL606 phosphodiesterase YP_003045417.1 2362826 R 413997 CDS YP_003045418.1 254162310 8176720 complement(2363433..2364077) 1 NC_012967.1 similar to b2301; hypothetical protein 2364077 yfcF 8176720 yfcF Escherichia coli B str. REL606 hypothetical protein YP_003045418.1 2363433 R 413997 CDS YP_003045419.1 254162311 8176721 2364213..2364860 1 NC_012967.1 similar to b2302; glutathione S-transferase 2364860 yfcG 8176721 yfcG Escherichia coli B str. REL606 glutathione S-transferase YP_003045419.1 2364213 D 413997 CDS YP_003045420.1 254162312 8179126 2364917..2365279 1 NC_012967.1 catalyzes the formation of dihydromonapterin triphosphate from dihydroneopterin triphosphate; D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase 2365279 folX 8179126 folX Escherichia coli B str. REL606 D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase YP_003045420.1 2364917 D 413997 CDS YP_003045421.1 254162313 8179127 2365300..2366193 1 NC_012967.1 similar to b2304; hypothetical protein 2366193 yfcH 8179127 yfcH Escherichia coli B str. REL606 hypothetical protein YP_003045421.1 2365300 D 413997 CDS YP_003045422.1 254162314 8176722 complement(2366241..2367131) 1 NC_012967.1 similar to b2305; hypothetical protein 2367131 yfcI 8176722 yfcI Escherichia coli B str. REL606 hypothetical protein YP_003045422.1 2366241 R 413997 CDS YP_003045423.1 254162315 8176723 complement(2367328..2368101) 1 NC_012967.1 similar to b2306; histidine/lysine/arginine/ornithine transporter subunit 2368101 hisP 8176723 hisP Escherichia coli B str. REL606 histidine/lysine/arginine/ornithine transporter subunit YP_003045423.1 2367328 R 413997 CDS YP_003045424.1 254162316 8176724 complement(2368109..2368825) 1 NC_012967.1 similar to b2307; histidine/lysine/arginine/ornithine transporter subunit 2368825 hisM 8176724 hisM Escherichia coli B str. REL606 histidine/lysine/arginine/ornithine transporter subunit YP_003045424.1 2368109 R 413997 CDS YP_003045425.1 254162317 8176725 complement(2368822..2369508) 1 NC_012967.1 similar to b2308; histidine/lysine/arginine/ornithine transporter subunit 2369508 hisQ 8176725 hisQ Escherichia coli B str. REL606 histidine/lysine/arginine/ornithine transporter subunit YP_003045425.1 2368822 R 413997 CDS YP_003045426.1 254162318 8178583 complement(2369598..2370380) 1 NC_012967.1 similar to b2309; histidine/lysine/arginine/ornithine transporter subunit 2370380 hisJ 8178583 hisJ Escherichia coli B str. REL606 histidine/lysine/arginine/ornithine transporter subunit YP_003045426.1 2369598 R 413997 CDS YP_003045427.1 254162319 8179128 complement(2370601..2371383) 1 NC_012967.1 similar to b2310; lysine/arginine/ornithine transporter subunit 2371383 argT 8179128 argT Escherichia coli B str. REL606 lysine/arginine/ornithine transporter subunit YP_003045427.1 2370601 R 413997 CDS YP_003045428.1 254162320 8176726 complement(2371649..2372218) 1 NC_012967.1 catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 2372218 ubiX 8176726 ubiX Escherichia coli B str. REL606 3-octaprenyl-4-hydroxybenzoate carboxy-lyase YP_003045428.1 2371649 R 413997 CDS YP_003045429.1 254162321 8176727 complement(2372313..2373830) 1 NC_012967.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 2373830 purF 8176727 purF Escherichia coli B str. REL606 amidophosphoribosyltransferase YP_003045429.1 2372313 R 413997 CDS YP_003045430.1 254162322 8176728 complement(2373867..2374355) 1 NC_012967.1 membrane protein required for colicin V production; colicin V production protein 2374355 cvpA 8176728 cvpA Escherichia coli B str. REL606 colicin V production protein YP_003045430.1 2373867 R 413997 CDS YP_003045431.1 254162323 8176729 complement(2374614..2375276) 1 NC_012967.1 similar to b2314; hypothetical protein 2375276 dedD 8176729 dedD Escherichia coli B str. REL606 hypothetical protein YP_003045431.1 2374614 R 413997 CDS YP_003045432.1 254162324 8179129 complement(2375266..2376534) 1 NC_012967.1 similar to b2315; bifunctional folylpolyglutamate synthase/ dihydrofolate synthase 2376534 folC 8179129 folC Escherichia coli B str. REL606 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase YP_003045432.1 2375266 R 413997 CDS YP_003045433.1 254162325 8179130 complement(2376604..2377518) 1 NC_012967.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta 2377518 accD 8179130 accD Escherichia coli B str. REL606 acetyl-CoA carboxylase subunit beta YP_003045433.1 2376604 R 413997 CDS YP_003045434.1 254162326 8176730 complement(2377674..2378333) 1 NC_012967.1 similar to b2317; hypothetical protein 2378333 dedA 8176730 dedA Escherichia coli B str. REL606 hypothetical protein YP_003045434.1 2377674 R 413997 CDS YP_003045435.1 254162327 8176731 complement(2378416..2379228) 1 NC_012967.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 2379228 truA 8176731 truA Escherichia coli B str. REL606 tRNA pseudouridine synthase A YP_003045435.1 2378416 R 413997 CDS YP_003045436.1 254162328 8176732 complement(2379228..2380241) 1 NC_012967.1 similar to b2319; putative semialdehyde dehydrogenase 2380241 usg 8176732 usg Escherichia coli B str. REL606 putative semialdehyde dehydrogenase YP_003045436.1 2379228 R 413997 CDS YP_003045437.1 254162329 8176733 complement(2380307..2381443) 1 NC_012967.1 similar to b2320; erythronate-4-phosphate dehydrogenase 2381443 pdxB 8176733 pdxB Escherichia coli B str. REL606 erythronate-4-phosphate dehydrogenase YP_003045437.1 2380307 R 413997 CDS YP_003045438.1 254162330 8176734 2381542..2382537 1 NC_012967.1 in Salmonella typhimurium Flk regulates flagellar biosynthesis by inhibition of the flagellar-associated type III secretion system; lowers secretion levels of the anti-sigma28 factor FlgM to the periplasm; inner membrane-anchored protein; flagella biosynthesis regulator 2382537 flk 8176734 flk Escherichia coli B str. REL606 flagella biosynthesis regulator YP_003045438.1 2381542 D 413997 CDS YP_003045439.1 254162331 8176735 complement(2382534..2383712) 1 NC_012967.1 similar to b2322; hypothetical protein 2383712 yfcJ 8176735 yfcJ Escherichia coli B str. REL606 hypothetical protein YP_003045439.1 2382534 R 413997 CDS YP_003045440.1 254162332 8176736 complement(2383977..2385197) 1 NC_012967.1 FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase I 2385197 fabB 8176736 fabB Escherichia coli B str. REL606 3-oxoacyl-(acyl carrier protein) synthase I YP_003045440.1 2383977 R 413997 CDS YP_003045441.1 254162333 8179131 2385356..2387362 1 NC_012967.1 catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules; 5-methylaminomethyl-2-thiouridine methyltransferase 2387362 mnmC 8179131 mnmC Escherichia coli B str. REL606 5-methylaminomethyl-2-thiouridine methyltransferase YP_003045441.1 2385356 D 413997 CDS YP_003045442.1 254162334 8176737 complement(2387483..2387761) 1 NC_012967.1 similar to b2325; hypothetical protein 2387761 yfcL 8176737 yfcL Escherichia coli B str. REL606 hypothetical protein YP_003045442.1 2387483 R 413997 CDS YP_003045443.1 254162335 8176738 complement(2387795..2388343) 1 NC_012967.1 similar to b2326; hypothetical protein 2388343 yfcM 8176738 yfcM Escherichia coli B str. REL606 hypothetical protein YP_003045443.1 2387795 R 413997 CDS YP_003045444.1 254162336 8176739 complement(2388343..2389152) 1 NC_012967.1 similar to b2327; hypothetical protein 2389152 yfcA 8176739 yfcA Escherichia coli B str. REL606 hypothetical protein YP_003045444.1 2388343 R 413997 CDS YP_003045445.1 254162337 8176740 complement(2389152..2389976) 1 NC_012967.1 D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm; penicillin-insensitive murein endopeptidase 2389976 mepA 8176740 mepA Escherichia coli B str. REL606 penicillin-insensitive murein endopeptidase YP_003045445.1 2389152 R 413997 CDS YP_003045446.1 254162338 8176741 complement(2389980..2391065) 1 NC_012967.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 2391065 aroC 8176741 aroC Escherichia coli B str. REL606 chorismate synthase YP_003045446.1 2389980 R 413997 CDS YP_003045447.1 254162339 8176742 complement(2391100..2392032) 1 NC_012967.1 involved in methylation of ribosomal protein L3; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 2392032 yfcB 8176742 yfcB Escherichia coli B str. REL606 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase YP_003045447.1 2391100 R 413997 CDS YP_003045448.1 254162340 8176743 2392198..2392749 1 NC_012967.1 similar to b2331; hypothetical protein 2392749 yfcN 8176743 yfcN Escherichia coli B str. REL606 hypothetical protein YP_003045448.1 2392198 D 413997 CDS YP_003045449.1 254162341 8178584 complement(2392875..2393672) 1 NC_012967.1 similar to b2332; hypothetical protein 2393672 yfcO 8178584 yfcO Escherichia coli B str. REL606 hypothetical protein YP_003045449.1 2392875 R 413997 CDS YP_003045450.1 254162342 8176744 complement(2393701..2394252) 1 NC_012967.1 similar to b2333; putative fimbrial-like adhesin protein 2394252 yfcP 8176744 yfcP Escherichia coli B str. REL606 putative fimbrial-like adhesin protein YP_003045450.1 2393701 R 413997 CDS YP_003045451.1 254162343 8176745 complement(2394249..2394728) 1 NC_012967.1 similar to b2334; putative fimbrial-like adhesin protein 2394728 yfcQ 8176745 yfcQ Escherichia coli B str. REL606 putative fimbrial-like adhesin protein YP_003045451.1 2394249 R 413997 CDS YP_003045452.1 254162344 8176746 complement(2394725..2395231) 1 NC_012967.1 similar to b2335; putative fimbrial-like adhesin protein 2395231 yfcR 8176746 yfcR Escherichia coli B str. REL606 putative fimbrial-like adhesin protein YP_003045452.1 2394725 R 413997 CDS YP_003045453.1 254162345 8176747 complement(2395248..2396000) 1 NC_012967.1 similar to b2336; putative periplasmic pilus chaperone 2396000 yfcS 8176747 yfcS Escherichia coli B str. REL606 putative periplasmic pilus chaperone YP_003045453.1 2395248 R 413997 CDS YP_003045454.1 254162346 8178585 complement(2396020..2398665) 1 NC_012967.1 similar to b2337-b2338; putative outer membrane export usher protein 2398665 yfcTU 8178585 yfcTU Escherichia coli B str. REL606 putative outer membrane export usher protein YP_003045454.1 2396020 R 413997 CDS YP_003045455.1 254162347 8178586 complement(2398748..2399311) 1 NC_012967.1 similar to b2339; putative fimbrial-like adhesin protein 2399311 yfcV 8178586 yfcV Escherichia coli B str. REL606 putative fimbrial-like adhesin protein YP_003045455.1 2398748 R 413997 CDS YP_003045456.1 254162348 8176748 complement(2399991..2400476) 1 NC_012967.1 similar to b2340; phosphohistidine phosphatase 2400476 sixA 8176748 sixA Escherichia coli B str. REL606 phosphohistidine phosphatase YP_003045456.1 2399991 R 413997 CDS YP_003045457.1 254162349 8176749 complement(2400679..2402823) 1 NC_012967.1 multifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities: forms a heterotetramer with FadI; similar to FadA2B2 complex; involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate; multifunctional fatty acid oxidation complex subunit alpha 2402823 fadJ 8176749 fadJ Escherichia coli B str. REL606 multifunctional fatty acid oxidation complex subunit alpha YP_003045457.1 2400679 R 413997 CDS YP_003045458.1 254162350 8176750 complement(2402823..2404133) 1 NC_012967.1 FadI; fatty acid oxidation complex component beta; functions in a heterotetramer with FadJ; similar to FadA2B2 complex; functions in beta-oxidation of fatty acids during anaerobic growth; 3-ketoacyl-CoA thiolase 2404133 fadI 8176750 fadI Escherichia coli B str. REL606 3-ketoacyl-CoA thiolase YP_003045458.1 2402823 R 413997 CDS YP_003045459.1 254162351 8176751 complement(2404314..2404598) 1 NC_012967.1 similar to b2343; hypothetical protein 2404598 yfcZ 8176751 yfcZ Escherichia coli B str. REL606 hypothetical protein YP_003045459.1 2404314 R 413997 CDS YP_003045460.1 254162352 8176752 2404964..2406310 1 NC_012967.1 similar to b2344; long-chain fatty acid outer membrane transporter 2406310 fadL 8176752 fadL Escherichia coli B str. REL606 long-chain fatty acid outer membrane transporter YP_003045460.1 2404964 D 413997 CDS YP_003045461.1 254162353 8176753 complement(2407457..2407960) 1 NC_012967.1 IS1 protein InsB 2407960 insB-18 8176753 insB-18 Escherichia coli B str. REL606 IS1 protein InsB YP_003045461.1 2407457 R 413997 CDS YP_003045462.1 254162354 8176754 complement(2407879..2408154) 1 NC_012967.1 IS1 protein InsA 2408154 insA-18 8176754 insA-18 Escherichia coli B str. REL606 IS1 protein InsA YP_003045462.1 2407879 R 413997 CDS YP_003045463.1 254162355 8176755 complement(2408694..2409449) 1 NC_012967.1 similar to b2346; putative lipoprotein 2409449 vacJ 8176755 vacJ Escherichia coli B str. REL606 putative lipoprotein YP_003045463.1 2408694 R 413997 CDS YP_003045464.1 254162356 8176756 2409743..2410675 1 NC_012967.1 similar to b2347; putative inner membrane protein 2410675 yfdC 8176756 yfdC Escherichia coli B str. REL606 putative inner membrane protein YP_003045464.1 2409743 D 413997 CDS YP_003045465.1 254162357 8178589 complement(2410921..2411856) 1 NC_012967.1 regulates the synthesis and expression of the dsdXA operon and dadA gene; DNA-binding transcriptional regulator DsdC 2411856 dsdC 8178589 dsdC Escherichia coli B str. REL606 DNA-binding transcriptional regulator DsdC YP_003045465.1 2410921 R 413997 CDS YP_003045466.1 254162358 8176757 2412074..2413411 1 NC_012967.1 member of the Gnt family of gluconate transporters; not involved in gluconate transport; unknown function; permease DsdX 2413411 dsdX 8176757 dsdX Escherichia coli B str. REL606 permease DsdX YP_003045466.1 2412074 D 413997 CDS YP_003045467.1 254162359 8176758 2413429..2414757 1 NC_012967.1 catalyzes the formation of pyruvate from serine; D-serine dehydratase 2414757 dsdA 8176758 dsdA Escherichia coli B str. REL606 D-serine dehydratase YP_003045467.1 2413429 D 413997 CDS YP_003045468.1 254162360 8176759 complement(2414865..2416403) 1 NC_012967.1 similar to b2367; putative multidrug efflux system 2416403 emrY 8176759 emrY Escherichia coli B str. REL606 putative multidrug efflux system YP_003045468.1 2414865 R 413997 CDS YP_003045469.1 254162361 8176760 complement(2416403..2417566) 1 NC_012967.1 similar to b2368; EmrKY-TolC multidrug resistance efflux pump, membrane fusion protein component 2417566 emrK 8176760 emrK Escherichia coli B str. REL606 EmrKY-TolC multidrug resistance efflux pump, membrane fusion protein component YP_003045469.1 2416403 R 413997 CDS YP_003045470.1 254162362 8179132 2417982..2418596 1 NC_012967.1 response regulator in two-component regulatory system with EvgS; phosphorylated EvgA activates ompC, emrKY, gadABC, hdeAB and others genes; involved in acid resistance, osmotic adaption, and drug resistance; DNA-binding transcriptional activator EvgA 2418596 evgA 8179132 evgA Escherichia coli B str. REL606 DNA-binding transcriptional activator EvgA YP_003045470.1 2417982 D 413997 CDS YP_003045471.1 254162363 8176761 2418601..2422194 1 NC_012967.1 similar to b2370; hybrid sensory histidine kinase in two-component regulatory system with EvgA 2422194 evgS 8176761 evgS Escherichia coli B str. REL606 hybrid sensory histidine kinase in two-component regulatory system with EvgA YP_003045471.1 2418601 D 413997 CDS YP_003045472.1 254162364 8176762 complement(2422250..2423395) 1 NC_012967.1 similar to b2371; hypothetical protein 2423395 yfdE 8176762 yfdE Escherichia coli B str. REL606 hypothetical protein YP_003045472.1 2422250 R 413997 CDS YP_003045473.1 254162365 8176763 complement(2423469..2424413) 1 NC_012967.1 member of the AEC family of auxin efflux transporters; unknown function; putative transporter YfdV 2424413 yfdV 8176763 yfdV Escherichia coli B str. REL606 putative transporter YfdV YP_003045473.1 2423469 R 413997 CDS YP_003045474.1 254162366 8178590 complement(2424483..2426177) 1 NC_012967.1 catalyzes the formation of formyl-CoA from oxalyl-CoA; putative oxalyl-CoA decarboxylase 2426177 yfdU 8178590 yfdU Escherichia coli B str. REL606 putative oxalyl-CoA decarboxylase YP_003045474.1 2424483 R 413997 CDS YP_003045475.1 254162367 8178591 complement(2426231..2427481) 1 NC_012967.1 catalyzes the formation of oxalyl-CoA from oxalate and Formyl-CoA; formyl-coenzyme A transferase 2427481 yfdW 8178591 yfdW Escherichia coli B str. REL606 formyl-coenzyme A transferase YP_003045475.1 2426231 R 413997 CDS YP_003045476.1 254162368 8176764 complement(2427994..2428626) 1 NC_012967.1 similar to b2375; hypothetical protein 2428626 yfdX 8176764 yfdX Escherichia coli B str. REL606 hypothetical protein YP_003045476.1 2427994 R 413997 CDS YP_003045477.1 254162369 8179133 2428922..2429197 1 NC_012967.1 similar to b2376; putative lipoprotein involved in colanic acid biosynthesis 2429197 ypdI 8179133 ypdI Escherichia coli B str. REL606 putative lipoprotein involved in colanic acid biosynthesis YP_003045477.1 2428922 D 413997 CDS YP_003045478.1 254162370 8178592 complement(2429274..2429516) 1 NC_012967.1 similar to b2377; putative inner membrane protein 2429516 yfdY 8178592 yfdY Escherichia coli B str. REL606 putative inner membrane protein YP_003045478.1 2429274 R 413997 CDS YP_003045479.1 254162371 8176765 2429869..2430789 1 NC_012967.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(palmitoleoyl)-lipid IVA in cells subjected to cold shock; lipid A biosynthesis palmitoleoyl acyltransferase 2430789 ddg 8176765 ddg Escherichia coli B str. REL606 lipid A biosynthesis palmitoleoyl acyltransferase YP_003045479.1 2429869 D 413997 CDS YP_003045480.1 254162372 8176766 complement(2431281..2432519) 1 NC_012967.1 similar to b2379; aminotransferase 2432519 yfdZ 8176766 yfdZ Escherichia coli B str. REL606 aminotransferase YP_003045480.1 2431281 R 413997 CDS YP_003045481.1 254162373 8176767 2432896..2434593 1 NC_012967.1 similar to b2380; putative sensory kinase in two-component system with YpdB 2434593 ypdA 8176767 ypdA Escherichia coli B str. REL606 putative sensory kinase in two-component system with YpdB YP_003045481.1 2432896 D 413997 CDS YP_003045482.1 254162374 8178593 2434608..2435342 1 NC_012967.1 similar to b2381; putative response regulator in two-component system withYpdA 2435342 ypdB 8178593 ypdB Escherichia coli B str. REL606 putative response regulator in two-component system withYpdA YP_003045482.1 2434608 D 413997 CDS YP_003045483.1 254162375 8176768 2435355..2436212 1 NC_012967.1 similar to b2382; putative DNA-binding protein 2436212 ypdC 8176768 ypdC Escherichia coli B str. REL606 putative DNA-binding protein YP_003045483.1 2435355 D 413997 CDS YP_003045484.1 254162376 8176769 complement(2436215..2438710) 1 NC_012967.1 similar to b2383; PTS system Hpr component subunit IIA 2438710 ypdD 8176769 ypdD Escherichia coli B str. REL606 PTS system Hpr component subunit IIA YP_003045484.1 2436215 R 413997 CDS YP_003045485.1 254162377 8176770 complement(2438735..2439772) 1 NC_012967.1 metalloprotein; exoaminopeptidase 2439772 ypdE 8176770 ypdE Escherichia coli B str. REL606 exoaminopeptidase YP_003045485.1 2438735 R 413997 CDS YP_003045486.1 254162378 8176771 complement(2439772..2440857) 1 NC_012967.1 Xaa-Pro aminopeptidase; limited methionine aminopeptidase; aminopeptidase 2440857 ypdF 8176771 ypdF Escherichia coli B str. REL606 aminopeptidase YP_003045486.1 2439772 R 413997 CDS YP_003045487.1 254162379 8178594 complement(2440872..2442119) 1 NC_012967.1 similar to b2386; putative PTS system transporter subunit IIC 2442119 ypdG 8178594 ypdG Escherichia coli B str. REL606 putative PTS system transporter subunit IIC YP_003045487.1 2440872 R 413997 CDS YP_003045488.1 254162380 8176772 complement(2442141..2442467) 1 NC_012967.1 similar to b2387; putative PTS system transporter subunit IIB 2442467 ypdH 8176772 ypdH Escherichia coli B str. REL606 putative PTS system transporter subunit IIB YP_003045488.1 2442141 R 413997 CDS YP_003045489.1 254162381 8179134 complement(2442686..2443651) 1 NC_012967.1 catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate; glucokinase 2443651 glk 8179134 glk Escherichia coli B str. REL606 glucokinase YP_003045489.1 2442686 R 413997 CDS YP_003045490.1 254162382 8179135 2443855..2445111 1 NC_012967.1 similar to b2389; hypothetical protein 2445111 yfeO 8179135 yfeO Escherichia coli B str. REL606 hypothetical protein YP_003045490.1 2443855 D 413997 CDS YP_003045491.1 254162383 8176773 2445226..2445552 1 NC_012967.1 similar to b2390; hypothetical protein 2445552 ypeC 8176773 ypeC Escherichia coli B str. REL606 hypothetical protein YP_003045491.1 2445226 D 413997 CDS YP_003045492.1 254162384 8176774 complement(2445693..2446931) 1 NC_012967.1 similar to b2392; manganese transport protein MntH 2446931 mntH 8176774 mntH Escherichia coli B str. REL606 manganese transport protein MntH YP_003045492.1 2445693 R 413997 CDS YP_003045493.1 254162385 8176775 2447267..2448469 1 NC_012967.1 similar to b2393; nucleoside (except guanosine) transporter 2448469 nupC 8176775 nupC Escherichia coli B str. REL606 nucleoside (except guanosine) transporter YP_003045493.1 2447267 D 413997 CDS YP_003045494.1 254162386 8176776 complement(2448519..2450708) 1 NC_012967.1 similar to b2395; putative diguanylate cyclase 2450708 yfeA 8176776 yfeA Escherichia coli B str. REL606 putative diguanylate cyclase YP_003045494.1 2448519 R 413997 CDS YP_003045495.1 254162387 8176779 2451343..2451687 1 NC_012967.1 similar to b2398; putative DNA-binding transcriptional regulator 2451687 yfeC 8176779 yfeC Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003045495.1 2451343 D 413997 CDS YP_003045496.1 254162388 8176780 2451689..2452081 1 NC_012967.1 similar to b2399; putative DNA-binding transcriptional regulator 2452081 yfeD 8176780 yfeD Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003045496.1 2451689 D 413997 CDS YP_003045497.1 254162389 8179136 complement(2452133..2453548) 1 NC_012967.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 2453548 gltX 8179136 gltX Escherichia coli B str. REL606 glutamyl-tRNA synthetase YP_003045497.1 2452133 R 413997 CDS YP_003045498.1 254162390 8178595 2454324..2454665 1 NC_012967.1 hypothetical protein 2454665 8178595 ECB_02307 Escherichia coli B str. REL606 hypothetical protein YP_003045498.1 2454324 D 413997 CDS YP_003045499.1 254162391 8176785 complement(2454656..2455582) 1 NC_012967.1 similar to b2409; putative DNA-binding transcriptional regulator 2455582 yfeR 8176785 yfeR Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003045499.1 2454656 R 413997 CDS YP_003045500.1 254162392 8176786 2455672..2456670 1 NC_012967.1 similar to b2410; putative inner membrane protein 2456670 yfeH 8176786 yfeH Escherichia coli B str. REL606 putative inner membrane protein YP_003045500.1 2455672 D 413997 CDS YP_003045501.1 254162393 8176787 complement(2456667..2456885) 1 NC_012967.1 similar to b4546; hypothetical protein 2456885 ypeB 8176787 ypeB Escherichia coli B str. REL606 hypothetical protein YP_003045501.1 2456667 R 413997 CDS YP_003045502.1 254162394 8176788 complement(2456887..2458902) 1 NC_012967.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 2458902 ligA 8176788 ligA Escherichia coli B str. REL606 NAD-dependent DNA ligase LigA YP_003045502.1 2456887 R 413997 CDS YP_003045503.1 254162395 8179137 complement(2458973..2459959) 1 NC_012967.1 interacts with cell division protein FitsZ and may be required to anchor septal ring structure; cell division protein ZipA 2459959 zipA 8179137 zipA Escherichia coli B str. REL606 cell division protein ZipA YP_003045503.1 2458973 R 413997 CDS YP_003045504.1 254162396 8179138 2460189..2460950 1 NC_012967.1 putative role in sulfur assimilation; putative sulfate transport protein CysZ 2460950 cysZ 8179138 cysZ Escherichia coli B str. REL606 putative sulfate transport protein CysZ YP_003045504.1 2460189 D 413997 CDS YP_003045505.1 254162397 8176789 2461135..2462106 1 NC_012967.1 CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis; cysteine synthase A 2462106 cysK 8176789 cysK Escherichia coli B str. REL606 cysteine synthase A YP_003045505.1 2461135 D 413997 CDS YP_003045506.1 254162398 8176790 2462490..2462747 1 NC_012967.1 similar to b2415; PTS system phosphohistidinoprotein-hexose phosphotransferase subunit Hpr 2462747 ptsH 8176790 ptsH Escherichia coli B str. REL606 PTS system phosphohistidinoprotein-hexose phosphotransferase subunit Hpr YP_003045506.1 2462490 D 413997 CDS YP_003045507.1 254162399 8179139 2462792..2464519 1 NC_012967.1 Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system; phosphoenolpyruvate-protein phosphotransferase 2464519 ptsI 8179139 ptsI Escherichia coli B str. REL606 phosphoenolpyruvate-protein phosphotransferase YP_003045507.1 2462792 D 413997 CDS YP_003045508.1 254162400 8179140 2464560..2465069 1 NC_012967.1 functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose; PTS system glucose-specific transporter subunit 2465069 crr 8179140 crr Escherichia coli B str. REL606 PTS system glucose-specific transporter subunit YP_003045508.1 2464560 D 413997 CDS YP_003045509.1 254162401 8176791 complement(2465112..2465963) 1 NC_012967.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxal kinase 2465963 pdxK 8176791 pdxK Escherichia coli B str. REL606 pyridoxal kinase YP_003045509.1 2465112 R 413997 CDS YP_003045510.1 254162402 8176792 2466068..2466442 1 NC_012967.1 similar to b2419; hypothetical protein 2466442 yfeK 8176792 yfeK Escherichia coli B str. REL606 hypothetical protein YP_003045510.1 2466068 D 413997 CDS YP_003045511.1 254162403 8176793 2466475..2467209 1 NC_012967.1 similar to b2420; hypothetical protein 2467209 yfeS 8176793 yfeS Escherichia coli B str. REL606 hypothetical protein YP_003045511.1 2466475 D 413997 CDS YP_003045512.1 254162404 8176794 complement(2467414..2468325) 1 NC_012967.1 catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide; cysteine synthase B 2468325 cysM 8176794 cysM Escherichia coli B str. REL606 cysteine synthase B YP_003045512.1 2467414 R 413997 CDS YP_003045513.1 254162405 8179141 complement(2468459..2469556) 1 NC_012967.1 similar to b2422; sulfate/thiosulfate transporter subunit 2469556 cysA 8179141 cysA Escherichia coli B str. REL606 sulfate/thiosulfate transporter subunit YP_003045513.1 2468459 R 413997 CDS YP_003045514.1 254162406 8176795 complement(2469546..2469995) 1 NC_012967.1 similar to b2423; sulfate/thiosulfate transporter subunit 2469995 cysW 8176795 cysW Escherichia coli B str. REL606 sulfate/thiosulfate transporter subunit YP_003045514.1 2469546 R 413997 CDS YP_003045515.1 254162407 8176796 complement(2470421..2471254) 1 NC_012967.1 similar to b2424; sulfate/thiosulfate transporter subunit 2471254 cysU 8176796 cysU Escherichia coli B str. REL606 sulfate/thiosulfate transporter subunit YP_003045515.1 2470421 R 413997 CDS YP_003045516.1 254162408 8176797 complement(2471254..2472270) 1 NC_012967.1 similar to b2425; thiosulfate transporter subunit 2472270 cysP 8176797 cysP Escherichia coli B str. REL606 thiosulfate transporter subunit YP_003045516.1 2471254 R 413997 CDS YP_003045517.1 254162409 8178596 complement(2472574..2473365) 1 NC_012967.1 similar to b2426; short chain dehydrogenase 2473365 ucpA 8178596 ucpA Escherichia coli B str. REL606 short chain dehydrogenase YP_003045517.1 2472574 R 413997 CDS YP_003045518.1 254162410 8178597 complement(2473494..2474351) 1 NC_012967.1 similar to b2427; putative DNA-binding transcriptional regulator 2474351 yfeT 8178597 yfeT Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003045518.1 2473494 R 413997 CDS YP_003045519.1 254162411 8176798 2474515..2475411 1 NC_012967.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway; N-acetylmuramic acid-6-phosphate etherase 2475411 murQ 8176798 murQ Escherichia coli B str. REL606 N-acetylmuramic acid-6-phosphate etherase YP_003045519.1 2474515 D 413997 CDS YP_003045520.1 254162412 8176799 2475415..2476839 1 NC_012967.1 belongs to PEP-dependent PTS system; contains the PTS EIIBC domains; involved in uptake of exogenous N-acetylmuramic acid (MurNAc); requires crr-encoded enzyme IIA-glucose component; PTS system N-acetylmuramic acid transporter subunits EIIBC 2476839 murP 8176799 murP Escherichia coli B str. REL606 PTS system N-acetylmuramic acid transporter subunits EIIBC YP_003045520.1 2475415 D 413997 CDS YP_003045521.1 254162413 8176800 2476757..2476933 1 NC_012967.1 similar to b2430; hypothetical protein 2476933 yfeW 8176800 yfeW Escherichia coli B str. REL606 hypothetical protein YP_003045521.1 2476757 D 413997 CDS YP_003045522.1 254162414 8178598 complement(2477019..2477918) 1 NC_012967.1 similar to b2431; hypothetical protein 2477918 yfeX 8178598 yfeX Escherichia coli B str. REL606 hypothetical protein YP_003045522.1 2477019 R 413997 CDS YP_003045523.1 254162415 8176801 complement(2478014..2478589) 1 NC_012967.1 similar to b2432; hypothetical protein 2478589 yfeY 8176801 yfeY Escherichia coli B str. REL606 hypothetical protein YP_003045523.1 2478014 R 413997 CDS YP_003045524.1 254162416 8176802 complement(2478796..2479245) 1 NC_012967.1 similar to b2433; putative inner membrane protein 2479245 yfeZ 8176802 yfeZ Escherichia coli B str. REL606 putative inner membrane protein YP_003045524.1 2478796 R 413997 CDS YP_003045525.1 254162417 8176803 complement(2479232..2479657) 1 NC_012967.1 similar to b2434; putative acetyltransferase 2479657 ypeA 8176803 ypeA Escherichia coli B str. REL606 putative acetyltransferase YP_003045525.1 2479232 R 413997 CDS YP_003045526.1 254162418 8176804 2479871..2480740 1 NC_012967.1 similar to b2435; N-acetylmuramoyl-l-alanine amidase I 2480740 amiA 8176804 amiA Escherichia coli B str. REL606 N-acetylmuramoyl-l-alanine amidase I YP_003045526.1 2479871 D 413997 CDS YP_003045527.1 254162419 8178599 2480744..2481643 1 NC_012967.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis; coproporphyrinogen III oxidase 2481643 hemF 8178599 hemF Escherichia coli B str. REL606 coproporphyrinogen III oxidase YP_003045527.1 2480744 D 413997 CDS YP_003045528.1 254162420 8179142 complement(2481649..2482701) 1 NC_012967.1 activates the transcription of the ethanolamine utilization operon; transcriptional regulator EutR 2482701 yfeG 8179142 yfeG Escherichia coli B str. REL606 transcriptional regulator EutR YP_003045528.1 2481649 R 413997 CDS YP_003045529.1 254162421 8176805 complement(2482747..2483247) 1 NC_012967.1 similar to b2438; putative carboxysome structural protein with putative role in ethanolamine utilization 2483247 yffI 8176805 yffI Escherichia coli B str. REL606 putative carboxysome structural protein with putative role in ethanolamine utilization YP_003045529.1 2482747 R 413997 CDS YP_003045530.1 254162422 8176806 complement(2483260..2483919) 1 NC_012967.1 similar to b2439; putative carboxysome structural protein with putative role in ethanolamine utilization 2483919 eutL 8176806 eutL Escherichia coli B str. REL606 putative carboxysome structural protein with putative role in ethanolamine utilization YP_003045530.1 2483260 R 413997 CDS YP_003045531.1 254162423 8176807 complement(2483929..2484816) 1 NC_012967.1 catalyzes the formation of acetaldehyde from ethanolamine; ethanolamine ammonia-lyase small subunit 2484816 eutC 8176807 eutC Escherichia coli B str. REL606 ethanolamine ammonia-lyase small subunit YP_003045531.1 2483929 R 413997 CDS YP_003045532.1 254162424 8176808 complement(2484837..2486198) 1 NC_012967.1 similar to b2441; ethanolamine ammonia-lyase, large subunit, heavy chain 2486198 eutB 8176808 eutB Escherichia coli B str. REL606 ethanolamine ammonia-lyase, large subunit, heavy chain YP_003045532.1 2484837 R 413997 CDS YP_003045533.1 254162425 8176809 complement(2486210..2487613) 1 NC_012967.1 ethanolamine utilization protein EutA; reactivating factor for ethanolamine ammonia lyase 2487613 eutA 8176809 eutA Escherichia coli B str. REL606 reactivating factor for ethanolamine ammonia lyase YP_003045533.1 2486210 R 413997 CDS YP_003045534.1 254162426 8176810 complement(2487610..2488836) 1 NC_012967.1 similar to b2452; putative inner membrane protein 2488836 eutH 8176810 eutH Escherichia coli B str. REL606 putative inner membrane protein YP_003045534.1 2487610 R 413997 CDS YP_003045535.1 254162427 8176811 complement(2489153..2490340) 1 NC_012967.1 similar to b2453; putative alcohol dehydrogenase in ethanolamine utilization 2490340 eutG 8176811 eutG Escherichia coli B str. REL606 putative alcohol dehydrogenase in ethanolamine utilization YP_003045535.1 2489153 R 413997 CDS YP_003045536.1 254162428 8176812 complement(2490330..2491166) 1 NC_012967.1 similar to b2454; putative chaperonin, ethanolamine utilization protein 2491166 eutJ 8176812 eutJ Escherichia coli B str. REL606 putative chaperonin, ethanolamine utilization protein YP_003045536.1 2490330 R 413997 CDS YP_003045537.1 254162429 8178600 complement(2491177..2492580) 1 NC_012967.1 similar to b2455; putative aldehyde dehydrogenase, ethanolamine utilization protein 2492580 eutE 8178600 eutE Escherichia coli B str. REL606 putative aldehyde dehydrogenase, ethanolamine utilization protein YP_003045537.1 2491177 R 413997 CDS YP_003045538.1 254162430 8176813 complement(2492592..2492879) 1 NC_012967.1 similar to b2456; putative carboxysome structural protein, ethanolamine utilization protein 2492879 cchB 8176813 cchB Escherichia coli B str. REL606 putative carboxysome structural protein, ethanolamine utilization protein YP_003045538.1 2492592 R 413997 CDS YP_003045539.1 254162431 8176814 complement(2492986..2493279) 1 NC_012967.1 similar to b2457; putative carboxysome structural protein, ethanolamine utilization protein 2493279 cchA 8176814 cchA Escherichia coli B str. REL606 putative carboxysome structural protein, ethanolamine utilization protein YP_003045539.1 2492986 R 413997 CDS YP_003045540.1 254162432 8176815 complement(2493318..2494334) 1 NC_012967.1 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; phosphotransacetylase 2494334 eutD 8176815 eutD Escherichia coli B str. REL606 phosphotransacetylase YP_003045540.1 2493318 R 413997 CDS YP_003045541.1 254162433 8178601 complement(2494324..2495133) 1 NC_012967.1 similar to b2459; putative cobalamin adenosyltransferase in ethanolamine utilization 2495133 eutT 8178601 eutT Escherichia coli B str. REL606 putative cobalamin adenosyltransferase in ethanolamine utilization YP_003045541.1 2494324 R 413997 CDS YP_003045542.1 254162434 8178602 complement(2495130..2495831) 1 NC_012967.1 similar to b2460; hypothetical protein 2495831 eutQ 8178602 eutQ Escherichia coli B str. REL606 hypothetical protein YP_003045542.1 2495130 R 413997 CDS YP_003045543.1 254162435 8176816 complement(2495806..2496285) 1 NC_012967.1 similar to b2461; hypothetical protein 2496285 eutP 8176816 eutP Escherichia coli B str. REL606 hypothetical protein YP_003045543.1 2495806 R 413997 CDS YP_003045544.1 254162436 8176817 complement(2496298..2496633) 1 NC_012967.1 similar to b2462; putative carboxysome structural protein with putative role in ethanol utilization 2496633 ypfE 8176817 ypfE Escherichia coli B str. REL606 putative carboxysome structural protein with putative role in ethanol utilization YP_003045544.1 2496298 R 413997 CDS YP_003045545.1 254162437 8176818 complement(2496926..2499205) 1 NC_012967.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; malic enzyme 2499205 maeB 8176818 maeB Escherichia coli B str. REL606 malic enzyme YP_003045545.1 2496926 R 413997 CDS YP_003045546.1 254162438 8176819 2499494..2500444 1 NC_012967.1 similar to b2464; transaldolase A 2500444 talA 8176819 talA Escherichia coli B str. REL606 transaldolase A YP_003045546.1 2499494 D 413997 CDS YP_003045547.1 254162439 8176820 2500464..2502467 1 NC_012967.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 2502467 tktB 8176820 tktB Escherichia coli B str. REL606 transketolase YP_003045547.1 2500464 D 413997 CDS YP_003045548.1 254162440 8176821 complement(2502562..2503605) 1 NC_012967.1 similar to b2466; hypothetical protein 2503605 ypfG 8176821 ypfG Escherichia coli B str. REL606 hypothetical protein YP_003045548.1 2502562 R 413997 CDS YP_003045549.1 254162441 8179143 complement(2503731..2504306) 1 NC_012967.1 similar to b2467; putative NUDIX hydrolase 2504306 yffH 8179143 yffH Escherichia coli B str. REL606 putative NUDIX hydrolase YP_003045549.1 2503731 R 413997 CDS YP_003045550.1 254162442 8176822 complement(2504374..2506353) 1 NC_012967.1 unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic); putative oxidoreductase Fe-S binding subunit 2506353 aegA 8176822 aegA Escherichia coli B str. REL606 putative oxidoreductase Fe-S binding subunit YP_003045550.1 2504374 R 413997 CDS YP_003045551.1 254162443 8176823 2506559..2508259 1 NC_012967.1 similar to b2469; nitrate/nitrite sensor protein NarQ 2508259 narQ 8176823 narQ Escherichia coli B str. REL606 nitrate/nitrite sensor protein NarQ YP_003045551.1 2506559 D 413997 CDS YP_003045552.1 254162444 8179144 2508423..2511536 1 NC_012967.1 similar to b2470; aminoglycoside/multidrug efflux system 2511536 acrD 8179144 acrD Escherichia coli B str. REL606 aminoglycoside/multidrug efflux system YP_003045552.1 2508423 D 413997 CDS YP_003045553.1 254162445 8176824 2512075..2512431 1 NC_012967.1 similar to b2471; hypothetical protein 2512431 yffB 8176824 yffB Escherichia coli B str. REL606 hypothetical protein YP_003045553.1 2512075 D 413997 CDS YP_003045554.1 254162446 8176825 2512435..2513562 1 NC_012967.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.; succinyl-diaminopimelate desuccinylase 2513562 dapE 8176825 dapE Escherichia coli B str. REL606 succinyl-diaminopimelate desuccinylase YP_003045554.1 2512435 D 413997 CDS YP_003045555.1 254162447 8176826 2513590..2513790 1 NC_012967.1 similar to b4547; hypothetical protein 2513790 8176826 ECB_02364 Escherichia coli B str. REL606 hypothetical protein YP_003045555.1 2513590 D 413997 CDS YP_003045556.1 254162448 8176827 complement(2513900..2514598) 1 NC_012967.1 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase YpfH 2514598 ypfH 8176827 ypfH Escherichia coli B str. REL606 esterase YpfH YP_003045556.1 2513900 R 413997 CDS YP_003045557.1 254162449 8176828 complement(2514672..2516687) 1 NC_012967.1 similar to b2474; putative hydrolase 2516687 ypfI 8176828 ypfI Escherichia coli B str. REL606 putative hydrolase YP_003045557.1 2514672 R 413997 CDS YP_003045558.1 254162450 8178603 complement(2516702..2517565) 1 NC_012967.1 similar to b2475; hypothetical protein 2517565 ypfJ 8178603 ypfJ Escherichia coli B str. REL606 hypothetical protein YP_003045558.1 2516702 R 413997 CDS YP_003045559.1 254162451 8176829 complement(2517733..2518446) 1 NC_012967.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 2518446 purC 8176829 purC Escherichia coli B str. REL606 phosphoribosylaminoimidazole-succinocarboxamide synthase YP_003045559.1 2517733 R 413997 CDS YP_003045560.1 254162452 8176830 complement(2518659..2519693) 1 NC_012967.1 similar to b2477; lipoprotein 2519693 nlpB 8176830 nlpB Escherichia coli B str. REL606 lipoprotein YP_003045560.1 2518659 R 413997 CDS YP_003045561.1 254162453 8176831 complement(2519710..2520588) 1 NC_012967.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 2520588 dapA 8176831 dapA Escherichia coli B str. REL606 dihydrodipicolinate synthase YP_003045561.1 2519710 R 413997 CDS YP_003045562.1 254162454 8178604 2520734..2521306 1 NC_012967.1 negative transcriptional regulator of the gcvTHP operon; glycine cleavage system transcriptional repressor 2521306 gcvR 8178604 gcvR Escherichia coli B str. REL606 glycine cleavage system transcriptional repressor YP_003045562.1 2520734 D 413997 CDS YP_003045563.1 254162455 8176832 2521306..2521776 1 NC_012967.1 bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine; thioredoxin-dependent thiol peroxidase 2521776 bcp 8176832 bcp Escherichia coli B str. REL606 thioredoxin-dependent thiol peroxidase YP_003045563.1 2521306 D 413997 CDS YP_003045564.1 254162456 8176833 2522029..2522646 1 NC_012967.1 similar to b2481; hydrogenase 4, 4Fe-4S subunit 2522646 hyfA 8176833 hyfA Escherichia coli B str. REL606 hydrogenase 4, 4Fe-4S subunit YP_003045564.1 2522029 D 413997 CDS YP_003045565.1 254162457 8176834 2522646..2524664 1 NC_012967.1 similar to b2482; hydrogenase 4 subunit B 2524664 hyfB 8176834 hyfB Escherichia coli B str. REL606 hydrogenase 4 subunit B YP_003045565.1 2522646 D 413997 CDS YP_003045566.1 254162458 8178605 2525724..2527073 1 NC_012967.1 similar to b2484; hydrogenase 4 subunit D 2527073 hyfD 8178605 hyfD Escherichia coli B str. REL606 hydrogenase 4 subunit D YP_003045566.1 2525724 D 413997 CDS YP_003045567.1 254162459 8176836 2527088..2527738 1 NC_012967.1 interacts with formate dehydrogenase to produce an active formate hydrogenlyase complex which cleaves formate to dihydrogen and carbon dioxide; hydrogenase 4 membrane subunit 2527738 hyfE 8176836 hyfE Escherichia coli B str. REL606 hydrogenase 4 membrane subunit YP_003045567.1 2527088 D 413997 CDS YP_003045568.1 254162460 8176837 2527743..2529323 1 NC_012967.1 similar to b2486; hydrogenase 4 subunit F 2529323 hyfF 8176837 hyfF Escherichia coli B str. REL606 hydrogenase 4 subunit F YP_003045568.1 2527743 D 413997 CDS YP_003045569.1 254162461 8179145 2529313..2530980 1 NC_012967.1 similar to b2487; hydrogenase 4, subunit 2530980 hyfG 8179145 hyfG Escherichia coli B str. REL606 hydrogenase 4, subunit YP_003045569.1 2529313 D 413997 CDS YP_003045570.1 254162462 8176838 2530990..2531529 1 NC_012967.1 probable electron transfer protein for hydrogenase 4; hydrogenase 4 is believed to be silent in E. coli under conditions tested so far; hydrogenase 4 subunit H 2531529 hyfH 8176838 hyfH Escherichia coli B str. REL606 hydrogenase 4 subunit H YP_003045570.1 2530990 D 413997 CDS YP_003045571.1 254162463 8176839 2531526..2532284 1 NC_012967.1 similar to b2489; hydrogenase 4, Fe-S subunit 2532284 hyfI 8176839 hyfI Escherichia coli B str. REL606 hydrogenase 4, Fe-S subunit YP_003045571.1 2531526 D 413997 CDS YP_003045572.1 254162464 8179146 2532277..2532690 1 NC_012967.1 similar to b2490; putative processing element hydrogenase 4 2532690 hyfJ 8179146 hyfJ Escherichia coli B str. REL606 putative processing element hydrogenase 4 YP_003045572.1 2532277 D 413997 CDS YP_003045573.1 254162465 8176840 2532726..2534732 1 NC_012967.1 similar to b2491; DNA-binding transcriptional activator, formate sensing 2534732 hyfR 8176840 hyfR Escherichia coli B str. REL606 DNA-binding transcriptional activator, formate sensing YP_003045573.1 2532726 D 413997 CDS YP_003045574.1 254162466 8176841 2534754..2535602 1 NC_012967.1 inner membrane protein presumed to act as a formate transporter; member of the hyf operon; putative formate transporter 2535602 focB 8176841 focB Escherichia coli B str. REL606 putative formate transporter YP_003045574.1 2534754 D 413997 CDS YP_003045575.1 254162467 8176842 complement(2535640..2536701) 1 NC_012967.1 similar to b2493; putative inner membrane protein 2536701 perM 8176842 perM Escherichia coli B str. REL606 putative inner membrane protein YP_003045575.1 2535640 R 413997 CDS YP_003045576.1 254162468 8176843 2536914..2538377 1 NC_012967.1 similar to b2494; putative peptidase 2538377 yfgC 8176843 yfgC Escherichia coli B str. REL606 putative peptidase YP_003045576.1 2536914 D 413997 CDS YP_003045577.1 254162469 8176844 2538398..2538757 1 NC_012967.1 similar to b2495; putative oxidoreductase 2538757 yfgD 8176844 yfgD Escherichia coli B str. REL606 putative oxidoreductase YP_003045577.1 2538398 D 413997 CDS YP_003045578.1 254162470 8176845 complement(2538895..2539641) 1 NC_012967.1 controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP; DNA replication initiation factor 2539641 hda 8176845 hda Escherichia coli B str. REL606 DNA replication initiation factor YP_003045578.1 2538895 R 413997 CDS YP_003045579.1 254162471 8176846 complement(2539691..2540980) 1 NC_012967.1 similar to b2497; uracil transporter 2540980 uraA 8176846 uraA Escherichia coli B str. REL606 uracil transporter YP_003045579.1 2539691 R 413997 CDS YP_003045580.1 254162472 8179147 complement(2541066..2541692) 1 NC_012967.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 2541692 upp 8179147 upp Escherichia coli B str. REL606 uracil phosphoribosyltransferase YP_003045580.1 2541066 R 413997 CDS YP_003045581.1 254162473 8176847 2542017..2543054 1 NC_012967.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 2543054 purM 8176847 purM Escherichia coli B str. REL606 phosphoribosylaminoimidazole synthetase YP_003045581.1 2542017 D 413997 CDS YP_003045582.1 254162474 8176848 2543054..2543692 1 NC_012967.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 2543692 purN 8176848 purN Escherichia coli B str. REL606 phosphoribosylglycinamide formyltransferase YP_003045582.1 2543054 D 413997 CDS YP_003045583.1 254162475 8176849 2543863..2545929 1 NC_012967.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase 2545929 ppk 8176849 ppk Escherichia coli B str. REL606 polyphosphate kinase YP_003045583.1 2543863 D 413997 CDS YP_003045584.1 254162476 8176850 2545934..2547475 1 NC_012967.1 similar to b2502; exopolyphosphatase 2547475 ppx 8176850 ppx Escherichia coli B str. REL606 exopolyphosphatase YP_003045584.1 2545934 D 413997 CDS YP_003045585.1 254162477 8176851 complement(2547514..2549757) 1 NC_012967.1 similar to b2503; putative inner membrane protein 2549757 yfgF 8176851 yfgF Escherichia coli B str. REL606 putative inner membrane protein YP_003045585.1 2547514 R 413997 CDS YP_003045586.1 254162478 8178606 2550109..2550300 1 NC_012967.1 similar to b2504; hypothetical protein 2550300 yfgG 8178606 yfgG Escherichia coli B str. REL606 hypothetical protein YP_003045586.1 2550109 D 413997 CDS YP_003045587.1 254162479 8176852 2550611..2551129 1 NC_012967.1 similar to b2505; putative outer membrane lipoprotein 2551129 yfgH 8176852 yfgH Escherichia coli B str. REL606 putative outer membrane lipoprotein YP_003045587.1 2550611 D 413997 CDS YP_003045588.1 254162480 8176853 2551145..2551684 1 NC_012967.1 similar to b2506; hypothetical protein 2551684 yfgI 8176853 yfgI Escherichia coli B str. REL606 hypothetical protein YP_003045588.1 2551145 D 413997 CDS YP_003045589.1 254162481 8176854 complement(2551777..2553354) 1 NC_012967.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 2553354 guaA 8176854 guaA Escherichia coli B str. REL606 GMP synthase YP_003045589.1 2551777 R 413997 CDS YP_003045590.1 254162482 8176855 complement(2553423..2554889) 1 NC_012967.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 2554889 guaB 8176855 guaB Escherichia coli B str. REL606 inosine 5'-monophosphate dehydrogenase YP_003045590.1 2553423 R 413997 CDS YP_003045591.1 254162483 8179148 2555051..2556421 1 NC_012967.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 2556421 xseA 8179148 xseA Escherichia coli B str. REL606 exodeoxyribonuclease VII large subunit YP_003045591.1 2555051 D 413997 CDS YP_003045592.1 254162484 8176856 complement(2556418..2556633) 1 NC_012967.1 similar to b2510; hypothetical protein 2556633 yfgJ 8176856 yfgJ Escherichia coli B str. REL606 hypothetical protein YP_003045592.1 2556418 R 413997 CDS YP_003045593.1 254162485 8176857 complement(2556703..2558175) 1 NC_012967.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 2558175 engA 8176857 engA Escherichia coli B str. REL606 GTP-binding protein EngA YP_003045593.1 2556703 R 413997 CDS YP_003045594.1 254162486 8176858 complement(2558293..2559471) 1 NC_012967.1 with YaeT, YfiO, and NlpB forms a complex involved in outer membrane protein biogenesis; outer membrane protein assembly complex subunit YfgL 2559471 yfgL 8176858 yfgL Escherichia coli B str. REL606 outer membrane protein assembly complex subunit YfgL YP_003045594.1 2558293 R 413997 CDS YP_003045595.1 254162487 8179149 complement(2559482..2560102) 1 NC_012967.1 similar to b2513; hypothetical protein 2560102 yfgM 8179149 yfgM Escherichia coli B str. REL606 hypothetical protein YP_003045595.1 2559482 R 413997 CDS YP_003045596.1 254162488 8176859 complement(2560120..2561394) 1 NC_012967.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 2561394 hisS 8176859 hisS Escherichia coli B str. REL606 histidyl-tRNA synthetase YP_003045596.1 2560120 R 413997 CDS YP_003045597.1 254162489 8179150 complement(2561505..2562623) 1 NC_012967.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 2562623 ispG 8179150 ispG Escherichia coli B str. REL606 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase YP_003045597.1 2561505 R 413997 CDS YP_003045598.1 254162490 8176860 complement(2562650..2563663) 1 NC_012967.1 similar to b2516; cytoskeletal protein RodZ 2563663 yfgA 8176860 yfgA Escherichia coli B str. REL606 cytoskeletal protein RodZ YP_003045598.1 2562650 R 413997 CDS YP_003045599.1 254162491 8176861 complement(2563948..2565102) 1 NC_012967.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N 2565102 yfgB 8176861 yfgB Escherichia coli B str. REL606 ribosomal RNA large subunit methyltransferase N YP_003045599.1 2563948 R 413997 CDS YP_003045600.1 254162492 8179151 complement(2565252..2565683) 1 NC_012967.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 2565683 ndk 8179151 ndk Escherichia coli B str. REL606 nucleoside diphosphate kinase YP_003045600.1 2565252 R 413997 CDS YP_003045601.1 254162493 8178607 complement(2565832..2568144) 1 NC_012967.1 penicillin-insensitive transglycosylase/transpeptidase; penicillin-binding protein 1C 2568144 pbpC 8178607 pbpC Escherichia coli B str. REL606 penicillin-binding protein 1C YP_003045601.1 2565832 R 413997 CDS YP_003045602.1 254162494 8176862 complement(2568145..2573106) 1 NC_012967.1 similar to b2520; hypothetical protein 2573106 yfhM 8176862 yfhM Escherichia coli B str. REL606 hypothetical protein YP_003045602.1 2568145 R 413997 CDS YP_003045603.1 254162495 8176863 2573313..2574158 1 NC_012967.1 catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds; 3-mercaptopyruvate sulfurtransferase 2574158 sseA 8176863 sseA Escherichia coli B str. REL606 3-mercaptopyruvate sulfurtransferase YP_003045603.1 2573313 D 413997 CDS YP_003045604.1 254162496 8176864 complement(2574976..2575752) 1 NC_012967.1 enhances serine sensitivity caused by inhibition of homoserine dehydrogenase I; enhanced serine sensitivity protein SseB 2575752 sseB 8176864 sseB Escherichia coli B str. REL606 enhanced serine sensitivity protein SseB YP_003045604.1 2574976 R 413997 CDS YP_003045605.1 254162497 8176865 complement(2575894..2577177) 1 NC_012967.1 catalyzes the removal of an N-terminal amino acid from a peptide or arylamide; aminopeptidase B 2577177 pepB 8176865 pepB Escherichia coli B str. REL606 aminopeptidase B YP_003045605.1 2575894 R 413997 CDS YP_003045606.1 254162498 8178608 complement(2577235..2577435) 1 NC_012967.1 similar to b2524; hypothetical protein 2577435 yfhJ 8178608 yfhJ Escherichia coli B str. REL606 hypothetical protein YP_003045606.1 2577235 R 413997 CDS YP_003045607.1 254162499 8176866 complement(2577447..2577782) 1 NC_012967.1 similar to b2525; [2Fe-2S] ferredoxin 2577782 fdx 8176866 fdx Escherichia coli B str. REL606 [2Fe-2S] ferredoxin YP_003045607.1 2577447 R 413997 CDS YP_003045608.1 254162500 8176867 complement(2577784..2579634) 1 NC_012967.1 involved in the maturation of iron-sulfur cluster-containing proteins; chaperone protein HscA 2579634 hscA 8176867 hscA Escherichia coli B str. REL606 chaperone protein HscA YP_003045608.1 2577784 R 413997 CDS YP_003045609.1 254162501 8178609 complement(2579651..2580166) 1 NC_012967.1 J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins; co-chaperone HscB 2580166 hscB 8178609 hscB Escherichia coli B str. REL606 co-chaperone HscB YP_003045609.1 2579651 R 413997 CDS YP_003045610.1 254162502 8176868 complement(2580262..2580585) 1 NC_012967.1 forms iron-sulfur clusters of ferredoxin [2FE-2S]; binds iron in the presence of the thioredoxin reductase system; forms homodimers and tetramers; similar to SufA protein; iron-sulfur cluster assembly protein 2580585 iscA 8176868 iscA Escherichia coli B str. REL606 iron-sulfur cluster assembly protein YP_003045610.1 2580262 R 413997 CDS YP_003045611.1 254162503 8176869 complement(2580602..2580988) 1 NC_012967.1 similar to b2529; scaffold protein 2580988 iscU 8176869 iscU Escherichia coli B str. REL606 scaffold protein YP_003045611.1 2580602 R 413997 CDS YP_003045612.1 254162504 8178610 complement(2581016..2582230) 1 NC_012967.1 catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis; cysteine desulfurase 2582230 iscS 8178610 iscS Escherichia coli B str. REL606 cysteine desulfurase YP_003045612.1 2581016 R 413997 CDS YP_003045613.1 254162505 8176870 complement(2582342..2582830) 1 NC_012967.1 regulates the expression of the iscRSUA operon; DNA-binding transcriptional regulator IscR 2582830 iscR 8176870 iscR Escherichia coli B str. REL606 DNA-binding transcriptional regulator IscR YP_003045613.1 2582342 R 413997 CDS YP_003045614.1 254162506 8178611 complement(2583282..2584022) 1 NC_012967.1 similar to b2532; putative methyltransferase 2584022 yfhQ 8178611 yfhQ Escherichia coli B str. REL606 putative methyltransferase YP_003045614.1 2583282 R 413997 CDS YP_003045615.1 254162507 8176871 2584141..2584944 1 NC_012967.1 similar to b2533; inositol monophosphatase 2584944 suhB 8176871 suhB Escherichia coli B str. REL606 inositol monophosphatase YP_003045615.1 2584141 D 413997 CDS YP_003045616.1 254162508 8176872 2585062..2585943 1 NC_012967.1 similar to b2534; putative peptidase 2585943 yfhR 8176872 yfhR Escherichia coli B str. REL606 putative peptidase YP_003045616.1 2585062 D 413997 CDS YP_003045617.1 254162509 8176873 2586134..2587414 1 NC_012967.1 similar to b2535; stationary phase inducible protein CsiE 2587414 csiE 8176873 csiE Escherichia coli B str. REL606 stationary phase inducible protein CsiE YP_003045617.1 2586134 D 413997 CDS YP_003045618.1 254162510 8176874 complement(2587406..2588545) 1 NC_012967.1 putative transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters; putative 3-phenylpropionic acid transporter 2588545 hcaT 8176874 hcaT Escherichia coli B str. REL606 putative 3-phenylpropionic acid transporter YP_003045618.1 2587406 R 413997 CDS YP_003045619.1 254162511 8176875 complement(2588705..2589595) 1 NC_012967.1 activator of 3-phenylpropionic acid catabolism; DNA-binding transcriptional regulator HcaR 2589595 hcaR 8176875 hcaR Escherichia coli B str. REL606 DNA-binding transcriptional regulator HcaR YP_003045619.1 2588705 R 413997 CDS YP_003045620.1 254162512 8179152 2589731..2591092 1 NC_012967.1 similar to b2538; 3-phenylpropionate dioxygenase, large subunit alpha 2591092 hcaE 8179152 hcaE Escherichia coli B str. REL606 3-phenylpropionate dioxygenase, large subunit alpha YP_003045620.1 2589731 D 413997 CDS YP_003045621.1 254162513 8176876 2591089..2591607 1 NC_012967.1 similar to b2539; 3-phenylpropionate dioxygenase subunit beta 2591607 hcaF 8176876 hcaF Escherichia coli B str. REL606 3-phenylpropionate dioxygenase subunit beta YP_003045621.1 2591089 D 413997 CDS YP_003045622.1 254162514 8176877 2591607..2591927 1 NC_012967.1 similar to b2540; 3-phenylpropionate dioxygenase ferredoxin subunit 2591927 hcaC 8176877 hcaC Escherichia coli B str. REL606 3-phenylpropionate dioxygenase ferredoxin subunit YP_003045622.1 2591607 D 413997 CDS YP_003045623.1 254162515 8176878 2591924..2592736 1 NC_012967.1 Converts cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol) into 3-(2,3-dihydroxylphenyl)propionate; 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase 2592736 hcaB 8176878 hcaB Escherichia coli B str. REL606 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase YP_003045623.1 2591924 D 413997 CDS YP_003045624.1 254162516 8176879 2592746..2593948 1 NC_012967.1 similar to b2542; phenylpropionate dioxygenase ferredoxin reductase subunit 2593948 hcaD 8176879 hcaD Escherichia coli B str. REL606 phenylpropionate dioxygenase ferredoxin reductase subunit YP_003045624.1 2592746 D 413997 CDS YP_003045625.1 254162517 8176880 2593973..2594467 1 NC_012967.1 similar to b2543; putative inner membrane protein 2594467 yphA 8176880 yphA Escherichia coli B str. REL606 putative inner membrane protein YP_003045625.1 2593973 D 413997 CDS YP_003045626.1 254162518 8176881 complement(2594515..2595387) 1 NC_012967.1 similar to b2544; hypothetical protein 2595387 yphB 8176881 yphB Escherichia coli B str. REL606 hypothetical protein YP_003045626.1 2594515 R 413997 CDS YP_003045627.1 254162519 8176882 complement(2595399..2596460) 1 NC_012967.1 similar to b2545; putative oxidoreductase, Zn-dependent and NAD(P)-binding 2596460 yphC 8176882 yphC Escherichia coli B str. REL606 putative oxidoreductase, Zn-dependent and NAD(P)-binding YP_003045627.1 2595399 R 413997 CDS YP_003045628.1 254162520 8176883 complement(2596526..2597524) 1 NC_012967.1 similar to b2546; putative sugar transporter subunit membrane component of ABC superfamily 2597524 yphD 8176883 yphD Escherichia coli B str. REL606 putative sugar transporter subunit membrane component of ABC superfamily YP_003045628.1 2596526 R 413997 CDS YP_003045629.1 254162521 8176884 complement(2597549..2599060) 1 NC_012967.1 similar to b2547; sugar ABC transporter ATP-binding protein 2599060 yphE 8176884 yphE Escherichia coli B str. REL606 sugar ABC transporter ATP-binding protein YP_003045629.1 2597549 R 413997 CDS YP_003045630.1 254162522 8178612 complement(2599083..2600066) 1 NC_012967.1 similar to b2548; putative sugar transporter subunit periplasmic-binding component of ABC superfamily 2600066 yphF 8178612 yphF Escherichia coli B str. REL606 putative sugar transporter subunit periplasmic-binding component of ABC superfamily YP_003045630.1 2599083 R 413997 CDS YP_003045631.1 254162523 8176885 complement(2600163..2603444) 1 NC_012967.1 similar to b2549; hypothetical protein 2603444 yphG 8176885 yphG Escherichia coli B str. REL606 hypothetical protein YP_003045631.1 2600163 R 413997 CDS YP_003045632.1 254162524 8176886 2603562..2604755 1 NC_012967.1 similar to b2550; putative DNA-binding transcriptional regulator 2604755 yphH 8176886 yphH Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003045632.1 2603562 D 413997 CDS YP_003045633.1 254162525 8176887 complement(2604953..2606206) 1 NC_012967.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 2606206 glyA 8176887 glyA Escherichia coli B str. REL606 serine hydroxymethyltransferase YP_003045633.1 2604953 R 413997 CDS YP_003045634.1 254162526 8176888 2606534..2607724 1 NC_012967.1 flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine; nitric oxide dioxygenase 2607724 hmpA 8176888 hmpA Escherichia coli B str. REL606 nitric oxide dioxygenase YP_003045634.1 2606534 D 413997 CDS YP_003045635.1 254162527 8179153 complement(2607769..2608107) 1 NC_012967.1 indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; nitrogen regulatory protein P-II 1 2608107 glnB 8179153 glnB Escherichia coli B str. REL606 nitrogen regulatory protein P-II 1 YP_003045635.1 2607769 R 413997 CDS YP_003045636.1 254162528 8176889 complement(2608168..2609502) 1 NC_012967.1 similar to b2554; putative DNA-binding response regulator in two-component system 2609502 yfhA 8176889 yfhA Escherichia coli B str. REL606 putative DNA-binding response regulator in two-component system YP_003045636.1 2608168 R 413997 CDS YP_003045637.1 254162529 8176890 complement(2609492..2610205) 1 NC_012967.1 similar to b2555; hypothetical protein 2610205 yfhG 8176890 yfhG Escherichia coli B str. REL606 hypothetical protein YP_003045637.1 2609492 R 413997 CDS YP_003045638.1 254162530 8179154 complement(2610370..2611797) 1 NC_012967.1 similar to b2556; putative sensory kinase in two-component system 2611797 yfhK 8179154 yfhK Escherichia coli B str. REL606 putative sensory kinase in two-component system YP_003045638.1 2610370 R 413997 CDS YP_003045639.1 254162531 8176891 complement(2612373..2616260) 1 NC_012967.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase 2616260 purL 8176891 purL Escherichia coli B str. REL606 phosphoribosylformylglycinamidine synthase YP_003045639.1 2612373 R 413997 CDS YP_003045640.1 254162532 8178613 2618084..2618359 1 NC_012967.1 IS1 protein InsA 2618359 insA-19 8178613 insA-19 Escherichia coli B str. REL606 IS1 protein InsA YP_003045640.1 2618084 D 413997 CDS YP_003045641.1 254162533 8176893 2618278..2618781 1 NC_012967.1 IS1 protein InsB 2618781 insB-19 8176893 insB-19 Escherichia coli B str. REL606 IS1 protein InsB YP_003045641.1 2618278 D 413997 CDS YP_003045642.1 254162534 8176894 complement(2618846..2619382) 1 NC_012967.1 similar to b2559; tRNA-specific adenosine deaminase 2619382 tadA 8176894 tadA Escherichia coli B str. REL606 tRNA-specific adenosine deaminase YP_003045642.1 2618846 R 413997 CDS YP_003045643.1 254162535 8178614 complement(2619407..2619979) 1 NC_012967.1 similar to b2560; hypothetical protein 2619979 yfhB 8178614 yfhB Escherichia coli B str. REL606 hypothetical protein YP_003045643.1 2619407 R 413997 CDS YP_003045644.1 254162536 8176895 2620251..2621099 1 NC_012967.1 similar to b2561; putative DNA-binding transcriptional regulator 2621099 yfhH 8176895 yfhH Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003045644.1 2620251 D 413997 CDS YP_003045645.1 254162537 8176896 2621155..2621415 1 NC_012967.1 similar to b2562; putative 4Fe-4S cluster-containing protein 2621415 yfhL 8176896 yfhL Escherichia coli B str. REL606 putative 4Fe-4S cluster-containing protein YP_003045645.1 2621155 D 413997 CDS YP_003045646.1 254162538 8176897 complement(2622110..2622490) 1 NC_012967.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase 2622490 acpS 8176897 acpS Escherichia coli B str. REL606 4'-phosphopantetheinyl transferase YP_003045646.1 2622110 R 413997 CDS YP_003045647.1 254162539 8176898 complement(2622490..2623221) 1 NC_012967.1 involved in the de novo synthesis of pyridoxine (Vitamin B6); pyridoxine 5'-phosphate synthase 2623221 pdxJ 8176898 pdxJ Escherichia coli B str. REL606 pyridoxine 5'-phosphate synthase YP_003045647.1 2622490 R 413997 CDS YP_003045648.1 254162540 8176899 complement(2623233..2623961) 1 NC_012967.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 2623961 recO 8176899 recO Escherichia coli B str. REL606 DNA repair protein RecO YP_003045648.1 2623233 R 413997 CDS YP_003045649.1 254162541 8176900 complement(2623973..2624878) 1 NC_012967.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 2624878 era 8176900 era Escherichia coli B str. REL606 GTP-binding protein Era YP_003045649.1 2623973 R 413997 CDS YP_003045650.1 254162542 8176901 complement(2624875..2625555) 1 NC_012967.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 2625555 rnc 8176901 rnc Escherichia coli B str. REL606 ribonuclease III YP_003045650.1 2624875 R 413997 CDS YP_003045651.1 254162543 8176902 complement(2625828..2626802) 1 NC_012967.1 catalyzes the cleavage of the amino-terminal leader peptide from secretory proteins; signal peptidase I 2626802 lepB 8176902 lepB Escherichia coli B str. REL606 signal peptidase I YP_003045651.1 2625828 R 413997 CDS YP_003045652.1 254162544 8176903 complement(2626818..2628617) 1 NC_012967.1 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 2628617 lepA 8176903 lepA Escherichia coli B str. REL606 GTP-binding protein LepA YP_003045652.1 2626818 R 413997 CDS YP_003045653.1 254162545 8176904 complement(2628815..2629294) 1 NC_012967.1 involved in the reduction of the SoxR iron-sulfur cluster; SoxR reducing system protein RseC 2629294 rseC 8176904 rseC Escherichia coli B str. REL606 SoxR reducing system protein RseC YP_003045653.1 2628815 R 413997 CDS YP_003045654.1 254162546 8179155 complement(2629291..2630247) 1 NC_012967.1 periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP; periplasmic negative regulator of sigmaE 2630247 rseB 8179155 rseB Escherichia coli B str. REL606 periplasmic negative regulator of sigmaE YP_003045654.1 2629291 R 413997 CDS YP_003045655.1 254162547 8176905 complement(2630247..2630897) 1 NC_012967.1 similar to b2572; anti-RNA polymerase sigma factor SigE 2630897 rseA 8176905 rseA Escherichia coli B str. REL606 anti-RNA polymerase sigma factor SigE YP_003045655.1 2630247 R 413997 CDS YP_003045656.1 254162548 8176906 complement(2630930..2631505) 1 NC_012967.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE 2631505 rpoE 8176906 rpoE Escherichia coli B str. REL606 RNA polymerase sigma factor RpoE YP_003045656.1 2630930 R 413997 CDS YP_003045657.1 254162549 8179156 2631913..2633535 1 NC_012967.1 catalyzes the formation of oxaloacetate from L-aspartate; L-aspartate oxidase 2633535 nadB 8179156 nadB Escherichia coli B str. REL606 L-aspartate oxidase YP_003045657.1 2631913 D 413997 CDS YP_003045658.1 254162550 8176907 complement(2633520..2634257) 1 NC_012967.1 similar to b2575; putative S-adenosyl-L-methionine-dependent methyltransferase 2634257 yfiC 8176907 yfiC Escherichia coli B str. REL606 putative S-adenosyl-L-methionine-dependent methyltransferase YP_003045658.1 2633520 R 413997 CDS YP_003045659.1 254162551 8176908 2634389..2635723 1 NC_012967.1 facilitates an early step in the assembly of the 50S subunit of the ribosome; ATP-dependent RNA helicase SrmB 2635723 srmB 8176908 srmB Escherichia coli B str. REL606 ATP-dependent RNA helicase SrmB YP_003045659.1 2634389 D 413997 CDS YP_003045660.1 254162552 8178615 complement(2635932..2636813) 1 NC_012967.1 similar to b2577; putative DNA-binding transcriptional regulator 2636813 yfiE 8178615 yfiE Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003045660.1 2635932 R 413997 CDS YP_003045661.1 254162553 8176909 2636916..2637503 1 NC_012967.1 similar to b2578; neutral amino-acid efflux protein 2637503 yfiK 8176909 yfiK Escherichia coli B str. REL606 neutral amino-acid efflux protein YP_003045661.1 2636916 D 413997 CDS YP_003045662.1 254162554 8176910 complement(2637559..2637942) 1 NC_012967.1 stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit; autonomous glycyl radical cofactor GrcA 2637942 yfiD 8176910 yfiD Escherichia coli B str. REL606 autonomous glycyl radical cofactor GrcA YP_003045662.1 2637559 R 413997 CDS YP_003045663.1 254162555 8178616 2638247..2638936 1 NC_012967.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 2638936 ung 8178616 ung Escherichia coli B str. REL606 uracil-DNA glycosylase YP_003045663.1 2638247 D 413997 CDS YP_003045664.1 254162556 8176911 complement(2638984..2640021) 1 NC_012967.1 similar to b2581; putative methyltransferase 2640021 yfiF 8176911 yfiF Escherichia coli B str. REL606 putative methyltransferase YP_003045664.1 2638984 R 413997 CDS YP_003045665.1 254162557 8176912 2640228..2640647 1 NC_012967.1 similar to b2582; thioredoxin 2 2640647 trxC 8176912 trxC Escherichia coli B str. REL606 thioredoxin 2 YP_003045665.1 2640228 D 413997 CDS YP_003045666.1 254162558 8178617 2640716..2641414 1 NC_012967.1 similar to b2583; hypothetical protein 2641414 yfiP 8178617 yfiP Escherichia coli B str. REL606 hypothetical protein YP_003045666.1 2640716 D 413997 CDS YP_003045667.1 254162559 8176913 2641446..2644106 1 NC_012967.1 similar to b2584; acyl-CoA synthetase NAD(P)-binding subunit/ATP-binding subunit 2644106 yfiQ 8176913 yfiQ Escherichia coli B str. REL606 acyl-CoA synthetase NAD(P)-binding subunit/ATP-binding subunit YP_003045667.1 2641446 D 413997 CDS YP_003045668.1 254162560 8176914 2644220..2645575 1 NC_012967.1 catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome; phosphatidylserine synthase 2645575 pssA 8176914 pssA Escherichia coli B str. REL606 phosphatidylserine synthase YP_003045668.1 2644220 D 413997 CDS YP_003045669.1 254162561 8176915 2645672..2645944 1 NC_012967.1 similar to b2586; hypothetical protein 2645944 yfiM 8176915 yfiM Escherichia coli B str. REL606 hypothetical protein YP_003045669.1 2645672 D 413997 CDS YP_003045670.1 254162562 8176916 complement(2645941..2647239) 1 NC_012967.1 similar to b2587; alpha-ketoglutarate transporter 2647239 kgtP 8176916 kgtP Escherichia coli B str. REL606 alpha-ketoglutarate transporter YP_003045670.1 2645941 R 413997 CDS YP_003045671.1 254162563 8176920 complement(2653008..2655581) 1 NC_012967.1 similar to b2592; protein disaggregation chaperone 2655581 clpB 8176920 clpB Escherichia coli B str. REL606 protein disaggregation chaperone YP_003045671.1 2653008 R 413997 CDS YP_003045672.1 254162564 8176921 complement(2655711..2656442) 1 NC_012967.1 similar to b2593; hypothetical protein 2656442 yfiH 8176921 yfiH Escherichia coli B str. REL606 hypothetical protein YP_003045672.1 2655711 R 413997 CDS YP_003045673.1 254162565 8179158 complement(2656439..2657419) 1 NC_012967.1 responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase D 2657419 rluD 8179158 rluD Escherichia coli B str. REL606 23S rRNA pseudouridine synthase D YP_003045673.1 2656439 R 413997 CDS YP_003045674.1 254162566 8176922 2657554..2658291 1 NC_012967.1 with YaeT, NlpB and YfgL forms a complex involved in the proper assembly and/or targeting of OMPs to the outer membrane; involved in resistance to ampicillin and tetracycline; outer membrane protein assembly complex subunit YfiO 2658291 yfiO 8176922 yfiO Escherichia coli B str. REL606 outer membrane protein assembly complex subunit YfiO YP_003045674.1 2657554 D 413997 CDS YP_003045675.1 254162567 8176923 2658562..2658903 1 NC_012967.1 associated with 30S ribosomal subunit; interferes with translation elongation; translation inhibitor protein RaiA 2658903 yfiA 8176923 yfiA Escherichia coli B str. REL606 translation inhibitor protein RaiA YP_003045675.1 2658562 D 413997 CDS YP_003045677.1 254162569 8176925 2659152..2660312 1 NC_012967.1 catalyzing the formation of prephenate from chorismate and the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; bifunctional chorismate mutase/prephenate dehydratase 2660312 pheA 8176925 pheA Escherichia coli B str. REL606 bifunctional chorismate mutase/prephenate dehydratase YP_003045677.1 2659152 D 413997 CDS YP_003045678.1 254162570 8179159 complement(2660355..2661476) 1 NC_012967.1 catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis; bifunctional chorismate mutase/prephenate dehydrogenase 2661476 tyrA 8179159 tyrA Escherichia coli B str. REL606 bifunctional chorismate mutase/prephenate dehydrogenase YP_003045678.1 2660355 R 413997 CDS YP_003045679.1 254162571 8176926 complement(2661487..2662557) 1 NC_012967.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 2662557 aroF 8176926 aroF Escherichia coli B str. REL606 phospho-2-dehydro-3-deoxyheptonate aldolase YP_003045679.1 2661487 R 413997 CDS YP_003045680.1 254162572 8176927 2662767..2663132 1 NC_012967.1 similar to b2602; hypothetical protein 2663132 yfiL 8176927 yfiL Escherichia coli B str. REL606 hypothetical protein YP_003045680.1 2662767 D 413997 CDS YP_003045681.1 254162573 8178618 2663282..2663800 1 NC_012967.1 similar to b2603; hypothetical protein 2663800 yfiR 8178618 yfiR Escherichia coli B str. REL606 hypothetical protein YP_003045681.1 2663282 D 413997 CDS YP_003045682.1 254162574 8176928 2663790..2665016 1 NC_012967.1 similar to b2604; hypothetical protein 2665016 yfiN 8176928 yfiN Escherichia coli B str. REL606 hypothetical protein YP_003045682.1 2663790 D 413997 CDS YP_003045683.1 254162575 8176929 2665032..2665514 1 NC_012967.1 similar to b2605; putative outer membrane lipoprotein 2665514 yfiB 8176929 yfiB Escherichia coli B str. REL606 putative outer membrane lipoprotein YP_003045683.1 2665032 D 413997 CDS YP_003045684.1 254162576 8178619 complement(2665590..2665937) 1 NC_012967.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 2665937 rplS 8178619 rplS Escherichia coli B str. REL606 50S ribosomal protein L19 YP_003045684.1 2665590 R 413997 CDS YP_003045685.1 254162577 8176930 complement(2665979..2666746) 1 NC_012967.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 2666746 trmD 8176930 trmD Escherichia coli B str. REL606 tRNA (guanine-N(1)-)-methyltransferase YP_003045685.1 2665979 R 413997 CDS YP_003045686.1 254162578 8176931 complement(2666777..2667325) 1 NC_012967.1 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 2667325 rimM 8176931 rimM Escherichia coli B str. REL606 16S rRNA-processing protein RimM YP_003045686.1 2666777 R 413997 CDS YP_003045687.1 254162579 8176932 complement(2667344..2667592) 1 NC_012967.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 2667592 rpsP 8176932 rpsP Escherichia coli B str. REL606 30S ribosomal protein S16 YP_003045687.1 2667344 R 413997 CDS YP_003045688.1 254162580 8176933 complement(2667729..2669090) 1 NC_012967.1 with 4.5S RNA forms a signal recognition particle involved in targeting and integration of inner membrane proteins; signal recognition particle protein 2669090 ffh 8176933 ffh Escherichia coli B str. REL606 signal recognition particle protein YP_003045688.1 2667729 R 413997 CDS YP_003045689.1 254162581 8176934 2669182..2670048 1 NC_012967.1 similar to b2611; putative inner membrane protein 2670048 ypjD 8176934 ypjD Escherichia coli B str. REL606 putative inner membrane protein YP_003045689.1 2669182 D 413997 CDS YP_003045690.1 254162582 8176935 2670159..2671355 1 NC_012967.1 similar to b4461; hypothetical protein 2671355 yfjD 8176935 yfjD Escherichia coli B str. REL606 hypothetical protein YP_003045690.1 2670159 D 413997 CDS YP_003045691.1 254162583 8176936 complement(2671410..2672003) 1 NC_012967.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 2672003 grpE 8176936 grpE Escherichia coli B str. REL606 heat shock protein GrpE YP_003045691.1 2671410 R 413997 CDS YP_003045692.1 254162584 8179160 2672126..2673004 1 NC_012967.1 catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 2673004 ppnK 8179160 ppnK Escherichia coli B str. REL606 inorganic polyphosphate/ATP-NAD kinase YP_003045692.1 2672126 D 413997 CDS YP_003045693.1 254162585 8176937 2673090..2674751 1 NC_012967.1 similar to b2616; recombination and repair protein 2674751 recN 8176937 recN Escherichia coli B str. REL606 recombination and repair protein YP_003045693.1 2673090 D 413997 CDS YP_003045694.1 254162586 8176938 2675089..2675241 1 NC_012967.1 similar to b2617; small membrane lipoprotein 2675241 smpA 8176938 smpA Escherichia coli B str. REL606 small membrane lipoprotein YP_003045694.1 2675089 D 413997 CDS YP_003045695.1 254162587 8179161 complement(2675303..2675593) 1 NC_012967.1 similar to b2618; hypothetical protein 2675593 yfjF 8179161 yfjF Escherichia coli B str. REL606 hypothetical protein YP_003045695.1 2675303 R 413997 CDS YP_003045696.1 254162588 8176939 complement(2675583..2676059) 1 NC_012967.1 similar to b2619; hypothetical protein 2676059 yfjG 8176939 yfjG Escherichia coli B str. REL606 hypothetical protein YP_003045696.1 2675583 R 413997 CDS YP_003045697.1 254162589 8176940 2676191..2676673 1 NC_012967.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 2676673 smpB 8176940 smpB Escherichia coli B str. REL606 SsrA-binding protein YP_003045697.1 2676191 D 413997 CDS YP_003045698.1 254162590 8179162 2677417..2678646 1 NC_012967.1 Fels-2 prophage protein 2678646 8179162 ECB_02509 Escherichia coli B str. REL606 Fels-2 prophage protein YP_003045698.1 2677417 D 413997 CDS YP_003045699.1 254162591 8176941 2678929..2680485 1 NC_012967.1 Recombinase 2680485 8176941 ECB_02510 Escherichia coli B str. REL606 Recombinase YP_003045699.1 2678929 D 413997 CDS YP_003045700.1 254162592 8176942 2680475..2681371 1 NC_012967.1 ParB family protein 2681371 8176942 ECB_02511 Escherichia coli B str. REL606 ParB family protein YP_003045700.1 2680475 D 413997 CDS YP_003045701.1 254162593 8178620 2681368..2682264 1 NC_012967.1 hypothetical protein 2682264 8178620 ECB_02512 Escherichia coli B str. REL606 hypothetical protein YP_003045701.1 2681368 D 413997 CDS YP_003045702.1 254162594 8176943 2682663..2682938 1 NC_012967.1 IS1 protein InsA 2682938 insA-20 8176943 insA-20 Escherichia coli B str. REL606 IS1 protein InsA YP_003045702.1 2682663 D 413997 CDS YP_003045703.1 254162595 8176944 2682857..2683360 1 NC_012967.1 IS1 protein InsB 2683360 insB-20 8176944 insB-20 Escherichia coli B str. REL606 IS1 protein InsB YP_003045703.1 2682857 D 413997 CDS YP_003045704.1 254162596 8178621 2683666..2684643 1 NC_012967.1 in Escherichia coli this gene is induced by carbon starvation and depends on sigma S and cAMP-CRP; the structure of the Gab protein shows it is a member of non-heme iron (II)-dependent oxygenase superfamily which includes clavamini acid synthases; forms homotetramers in solution; hypothetical protein 2684643 csiD 8178621 csiD Escherichia coli B str. REL606 hypothetical protein YP_003045704.1 2683666 D 413997 CDS YP_003045705.1 254162597 8176945 2684662..2685930 1 NC_012967.1 catalyzed the formation of 2-ketoglutarate from 2-hydroxyglutarate; hydroxyglutarate oxidase 2685930 ygaF 8176945 ygaF Escherichia coli B str. REL606 hydroxyglutarate oxidase YP_003045705.1 2684662 D 413997 CDS YP_003045706.1 254162598 8176946 2685953..2687401 1 NC_012967.1 catalyzes the formation of succinate from succinate semialdehyde; NADP dependent; succinate-semialdehyde dehydrogenase I 2687401 gabD 8176946 gabD Escherichia coli B str. REL606 succinate-semialdehyde dehydrogenase I YP_003045706.1 2685953 D 413997 CDS YP_003045707.1 254162599 8176947 2687415..2688695 1 NC_012967.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; 4-aminobutyrate aminotransferase 2688695 gabT 8176947 gabT Escherichia coli B str. REL606 4-aminobutyrate aminotransferase YP_003045707.1 2687415 D 413997 CDS YP_003045708.1 254162600 8176948 2689006..2690406 1 NC_012967.1 similar to b2663; gamma-aminobutyrate transporter 2690406 gabP 8176948 gabP Escherichia coli B str. REL606 gamma-aminobutyrate transporter YP_003045708.1 2689006 D 413997 CDS YP_003045709.1 254162601 8179163 2690427..2691089 1 NC_012967.1 regulator of gab gene expression; DNA-binding transcriptional regulator CsiR 2691089 ygaE 8179163 ygaE Escherichia coli B str. REL606 DNA-binding transcriptional regulator CsiR YP_003045709.1 2690427 D 413997 CDS YP_003045710.1 254162602 8176949 complement(2691090..2691539) 1 NC_012967.1 similar to b2665; LysM domain/BON superfamily protein 2691539 ygaU 8176949 ygaU Escherichia coli B str. REL606 LysM domain/BON superfamily protein YP_003045710.1 2691090 R 413997 CDS YP_003045711.1 254162603 8176950 complement(2691623..2691781) 1 NC_012967.1 similar to b2666; hypothetical protein 2691781 yqaE 8176950 yqaE Escherichia coli B str. REL606 hypothetical protein YP_003045711.1 2691623 R 413997 CDS YP_003045712.1 254162604 8176951 2691964..2692263 1 NC_012967.1 similar to b2667; putative DNA-binding transcriptional regulator 2692263 ygaV 8176951 ygaV Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003045712.1 2691964 D 413997 CDS YP_003045713.1 254162605 8176952 2692273..2692797 1 NC_012967.1 similar to b2668; putative inner membrane protein with hydrolase activity 2692797 ygaP 8176952 ygaP Escherichia coli B str. REL606 putative inner membrane protein with hydrolase activity YP_003045713.1 2692273 D 413997 CDS YP_003045714.1 254162606 8176953 complement(2692844..2693248) 1 NC_012967.1 similar to b2669; DNA binding protein 2693248 stpA 8176953 stpA Escherichia coli B str. REL606 DNA binding protein YP_003045714.1 2692844 R 413997 CDS YP_003045715.1 254162607 8178622 2693916..2694365 1 NC_012967.1 similar to b2670; putative inner membrane protein 2694365 ygaW 8178622 ygaW Escherichia coli B str. REL606 putative inner membrane protein YP_003045715.1 2693916 D 413997 CDS YP_003045716.1 254162608 8176954 complement(2694402..2694746) 1 NC_012967.1 similar to b2671; hypothetical protein 2694746 ygaC 8176954 ygaC Escherichia coli B str. REL606 hypothetical protein YP_003045716.1 2694402 R 413997 CDS YP_003045717.1 254162609 8178623 2694886..2695227 1 NC_012967.1 similar to b2672; hypothetical protein 2695227 ygaM 8178623 ygaM Escherichia coli B str. REL606 hypothetical protein YP_003045717.1 2694886 D 413997 CDS YP_003045718.1 254162610 8178624 2695475..2695720 1 NC_012967.1 similar to b2673; glutaredoxin-like protein 2695720 nrdH 8178624 nrdH Escherichia coli B str. REL606 glutaredoxin-like protein YP_003045718.1 2695475 D 413997 CDS YP_003045719.1 254162611 8176955 2695717..2696127 1 NC_012967.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein 2696127 nrdI 8176955 nrdI Escherichia coli B str. REL606 ribonucleotide reductase stimulatory protein YP_003045719.1 2695717 D 413997 CDS YP_003045720.1 254162612 8176956 2696100..2698244 1 NC_012967.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 2698244 nrdE 8176956 nrdE Escherichia coli B str. REL606 ribonucleotide-diphosphate reductase subunit alpha YP_003045720.1 2696100 D 413997 CDS YP_003045721.1 254162613 8176957 2698254..2699213 1 NC_012967.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 2699213 nrdF 8176957 nrdF Escherichia coli B str. REL606 ribonucleotide-diphosphate reductase subunit beta YP_003045721.1 2698254 D 413997 CDS YP_003045722.1 254162614 8176958 2699567..2700769 1 NC_012967.1 with ProWX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter ATP-binding subunit 2700769 proV 8176958 proV Escherichia coli B str. REL606 glycine betaine transporter ATP-binding subunit YP_003045722.1 2699567 D 413997 CDS YP_003045723.1 254162615 8178625 2700762..2701826 1 NC_012967.1 with ProVX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter membrane protein 2701826 proW 8178625 proW Escherichia coli B str. REL606 glycine betaine transporter membrane protein YP_003045723.1 2700762 D 413997 CDS YP_003045724.1 254162616 8176959 2701884..2702876 1 NC_012967.1 with ProVW, part of the high-affinity transport system for the osmoprotectant glycine betaine; glycine betaine transporter periplasmic subunit 2702876 proX 8176959 proX Escherichia coli B str. REL606 glycine betaine transporter periplasmic subunit YP_003045724.1 2701884 D 413997 CDS YP_003045725.1 254162617 8176960 2703168..2704352 1 NC_012967.1 similar to b2680-b2681; putative transporter 2704352 ygaXY 8176960 ygaXY Escherichia coli B str. REL606 putative transporter YP_003045725.1 2703168 D 413997 CDS YP_003045726.1 254162618 8176961 2704476..2705213 1 NC_012967.1 similar to b2682; putative transporter 2705213 ygaZ 8176961 ygaZ Escherichia coli B str. REL606 putative transporter YP_003045726.1 2704476 D 413997 CDS YP_003045727.1 254162619 8176962 2705203..2705538 1 NC_012967.1 similar to b2683; hypothetical protein 2705538 ygaH 8176962 ygaH Escherichia coli B str. REL606 hypothetical protein YP_003045727.1 2705203 D 413997 CDS YP_003045728.1 254162620 8176963 2705629..2706159 1 NC_012967.1 DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; negative regulator of the multidrug operon emrAB; transcriptional repressor MprA 2706159 emrR 8176963 emrR Escherichia coli B str. REL606 transcriptional repressor MprA YP_003045728.1 2705629 D 413997 CDS YP_003045729.1 254162621 8178626 2706286..2707458 1 NC_012967.1 similar to b2685; multidrug efflux system 2707458 emrA 8178626 emrA Escherichia coli B str. REL606 multidrug efflux system YP_003045729.1 2706286 D 413997 CDS YP_003045730.1 254162622 8179164 2707475..2709013 1 NC_012967.1 similar to b2686; multidrug efflux system protein 2709013 emrB 8179164 emrB Escherichia coli B str. REL606 multidrug efflux system protein YP_003045730.1 2707475 D 413997 CDS YP_003045731.1 254162623 8176964 complement(2709077..2709592) 1 NC_012967.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase 2709592 ygaG 8176964 ygaG Escherichia coli B str. REL606 S-ribosylhomocysteinase YP_003045731.1 2709077 R 413997 CDS YP_003045732.1 254162624 8178627 complement(2709742..2711298) 1 NC_012967.1 involved in the first step of glutathione biosynthesis; glutamate--cysteine ligase 2711298 gshA 8178627 gshA Escherichia coli B str. REL606 glutamate--cysteine ligase YP_003045732.1 2709742 R 413997 CDS YP_003045733.1 254162625 8176965 complement(2711371..2711799) 1 NC_012967.1 similar to b2689; inner membrane protein 2711799 yqaA 8176965 yqaA Escherichia coli B str. REL606 inner membrane protein YP_003045733.1 2711371 R 413997 CDS YP_003045734.1 254162626 8176966 complement(2711796..2712362) 1 NC_012967.1 YqaB; catalyzes the dephosphorylation of fructose 1-phosphate, 6-phosphogluconate and p-nitrophenyl phosphate (pNPP); presents beta-phosphoglucomutase activity at a lower extent; fructose-1-phosphatase 2712362 yqaB 8176966 yqaB Escherichia coli B str. REL606 fructose-1-phosphatase YP_003045734.1 2711796 R 413997 CDS YP_003045735.1 254162627 8176972 complement(2713820..2714005) 1 NC_012967.1 affects carbohydrate metabolism; has regulatory role in many processes; carbon storage regulator 2714005 csrA 8176972 csrA Escherichia coli B str. REL606 carbon storage regulator YP_003045735.1 2713820 R 413997 CDS YP_003045736.1 254162628 8176973 complement(2714240..2716870) 1 NC_012967.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 2716870 alaS 8176973 alaS Escherichia coli B str. REL606 alanyl-tRNA synthetase YP_003045736.1 2714240 R 413997 CDS YP_003045737.1 254162629 8176974 complement(2716998..2717498) 1 NC_012967.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 2717498 recX 8176974 recX Escherichia coli B str. REL606 recombination regulator RecX YP_003045737.1 2716998 R 413997 CDS YP_003045738.1 254162630 8179165 complement(2717567..2718628) 1 NC_012967.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 2718628 recA 8179165 recA Escherichia coli B str. REL606 recombinase A YP_003045738.1 2717567 R 413997 CDS YP_003045739.1 254162631 8178628 complement(2718708..2719205) 1 NC_012967.1 similar to b2700; competence damage-inducible protein A 2719205 ygaD 8178628 ygaD Escherichia coli B str. REL606 competence damage-inducible protein A YP_003045739.1 2718708 R 413997 CDS YP_003045740.1 254162632 8176975 complement(2719350..2720435) 1 NC_012967.1 membrane-bound lytic murein transglycosylase B; catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan; murein hydrolase B 2720435 mltB 8176975 mltB Escherichia coli B str. REL606 murein hydrolase B YP_003045740.1 2719350 R 413997 CDS YP_003045741.1 254162633 8176976 2720691..2721254 1 NC_012967.1 similar to b2702; PTS system glucitol/sorbitol-specific transporter subunit IIC 2721254 srlA 8176976 srlA Escherichia coli B str. REL606 PTS system glucitol/sorbitol-specific transporter subunit IIC YP_003045741.1 2720691 D 413997 CDS YP_003045742.1 254162634 8176977 2721251..2722210 1 NC_012967.1 similar to b2703; PTS system glucitol/sorbitol-specific transporter subunit IIB 2722210 srlE 8176977 srlE Escherichia coli B str. REL606 PTS system glucitol/sorbitol-specific transporter subunit IIB YP_003045742.1 2721251 D 413997 CDS YP_003045743.1 254162635 8176978 2722221..2722592 1 NC_012967.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system glucitol/sorbitol-specific transporter subunit IIA 2722592 srlB 8176978 srlB Escherichia coli B str. REL606 PTS system glucitol/sorbitol-specific transporter subunit IIA YP_003045743.1 2722221 D 413997 CDS YP_003045744.1 254162636 8176979 2722596..2723375 1 NC_012967.1 catalyzes the conversion of sorbitol 6-phosphate into fructose 6-phosphate; sorbitol-6-phosphate dehydrogenase 2723375 srlD 8176979 srlD Escherichia coli B str. REL606 sorbitol-6-phosphate dehydrogenase YP_003045744.1 2722596 D 413997 CDS YP_003045745.1 254162637 8176980 2723481..2723840 1 NC_012967.1 regulator for glucitol utilization; DNA-binding transcriptional activator GutM 2723840 gutM 8176980 gutM Escherichia coli B str. REL606 DNA-binding transcriptional activator GutM YP_003045745.1 2723481 D 413997 CDS YP_003045746.1 254162638 8178629 2723907..2724680 1 NC_012967.1 regulates genes involved in glucitol utilization; DNA-binding transcriptional repressor SrlR 2724680 srlR 8178629 srlR Escherichia coli B str. REL606 DNA-binding transcriptional repressor SrlR YP_003045746.1 2723907 D 413997 CDS YP_003045747.1 254162639 8176981 2724673..2725638 1 NC_012967.1 catalyzes the conversion of D-arabinose 5-phosphate to D-ribulose-5-phosphate; D-arabinose 5-phosphate isomerase 2725638 gutQ 8176981 gutQ Escherichia coli B str. REL606 D-arabinose 5-phosphate isomerase YP_003045747.1 2724673 D 413997 CDS YP_003045748.1 254162640 8176982 complement(2725635..2727149) 1 NC_012967.1 Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon; anaerobic nitric oxide reductase transcription regulator 2727149 ygaA 8176982 ygaA Escherichia coli B str. REL606 anaerobic nitric oxide reductase transcription regulator YP_003045748.1 2725635 R 413997 CDS YP_003045749.1 254162641 8176983 2727336..2728775 1 NC_012967.1 detoxifies nitric oxide using NADH; anaerobic nitric oxide reductase flavorubredoxin 2728775 norV 8176983 norV Escherichia coli B str. REL606 anaerobic nitric oxide reductase flavorubredoxin YP_003045749.1 2727336 D 413997 CDS YP_003045750.1 254162642 8179166 2728772..2729905 1 NC_012967.1 catalyzes the reduction of the rubredoxin moiety of nitric oxide reductase; nitric oxide reductase 2729905 ygbD 8179166 ygbD Escherichia coli B str. REL606 nitric oxide reductase YP_003045750.1 2728772 D 413997 CDS YP_003045751.1 254162643 8176984 complement(2730033..2732285) 1 NC_012967.1 carbamoyl phosphate phosphatase and maturation protein for [NiFe] hydrogenases; similar to b2712; carbamoyl phosphate phosphatase and maturation protein 2732285 hypF 8176984 hypF Escherichia coli B str. REL606 carbamoyl phosphate phosphatase and maturation protein YP_003045751.1 2730033 R 413997 CDS YP_003045752.1 254162644 8178630 complement(2732438..2732965) 1 NC_012967.1 involved in electron transport from formate to hydrogen; electron transport protein HydN 2732965 hydN 8178630 hydN Escherichia coli B str. REL606 electron transport protein HydN YP_003045752.1 2732438 R 413997 CDS YP_003045753.1 254162645 8179167 complement(2733114..2734127) 1 NC_012967.1 similar to b2714; DNA-binding transcriptional repressor 2734127 ascG 8179167 ascG Escherichia coli B str. REL606 DNA-binding transcriptional repressor YP_003045753.1 2733114 R 413997 CDS YP_003045754.1 254162646 8176985 2734384..2735841 1 NC_012967.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC 2735841 ascF 8176985 ascF Escherichia coli B str. REL606 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC YP_003045754.1 2734384 D 413997 CDS YP_003045755.1 254162647 8176986 2735850..2737274 1 NC_012967.1 similar to b2716; cryptic 6-phospho-beta-glucosidase 2737274 ascB 8176986 ascB Escherichia coli B str. REL606 cryptic 6-phospho-beta-glucosidase YP_003045755.1 2735850 D 413997 CDS YP_003045756.1 254162648 8176987 complement(2737433..2737903) 1 NC_012967.1 involved in processing C-terminal end of HycE; involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE; hydrogenase 3 maturation protease 2737903 hycI 8176987 hycI Escherichia coli B str. REL606 hydrogenase 3 maturation protease YP_003045756.1 2737433 R 413997 CDS YP_003045757.1 254162649 8176988 complement(2737896..2738306) 1 NC_012967.1 similar to b2718; protein required for maturation of hydrogenase 3; HycH 2738306 hycH 8176988 hycH Escherichia coli B str. REL606 HycH YP_003045757.1 2737896 R 413997 CDS YP_003045758.1 254162650 8178631 complement(2738303..2739070) 1 NC_012967.1 similar to b2719; hydrogenase 3 and formate hydrogenase complex, HycG subunit 2739070 hycG 8178631 hycG Escherichia coli B str. REL606 hydrogenase 3 and formate hydrogenase complex, HycG subunit YP_003045758.1 2738303 R 413997 CDS YP_003045759.1 254162651 8176989 complement(2739070..2739612) 1 NC_012967.1 electron transfer protein for hydrogenase-3; the formate hydrogenlyase complex comprises of a formate dehydrogenase, unidentified electron carriers and hydrogenase-3; in this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate; formate hydrogenlyase complex iron-sulfur subunit 2739612 hycF 8176989 hycF Escherichia coli B str. REL606 formate hydrogenlyase complex iron-sulfur subunit YP_003045759.1 2739070 R 413997 CDS YP_003045760.1 254162652 8176990 complement(2739622..2741331) 1 NC_012967.1 similar to b2721; hydrogenase 3, large subunit 2741331 hycE 8176990 hycE Escherichia coli B str. REL606 hydrogenase 3, large subunit YP_003045760.1 2739622 R 413997 CDS YP_003045761.1 254162653 8176991 complement(2741349..2742272) 1 NC_012967.1 similar to b2722; hydrogenase 3, membrane subunit 2742272 hycD 8176991 hycD Escherichia coli B str. REL606 hydrogenase 3, membrane subunit YP_003045761.1 2741349 R 413997 CDS YP_003045762.1 254162654 8176992 complement(2742275..2744101) 1 NC_012967.1 catalyzes the oxidation of formate to carbon dioxide and molecular hydrogen; formate hydrogenlyase comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (subunit 3); formate hydrogenlyase subunit 3 2744101 hycC 8176992 hycC Escherichia coli B str. REL606 formate hydrogenlyase subunit 3 YP_003045762.1 2742275 R 413997 CDS YP_003045763.1 254162655 8176993 complement(2744098..2744709) 1 NC_012967.1 similar to b2724; hydrogenase 3, Fe-S subunit 2744709 hycB 8176993 hycB Escherichia coli B str. REL606 hydrogenase 3, Fe-S subunit YP_003045763.1 2744098 R 413997 CDS YP_003045764.1 254162656 8178632 complement(2744834..2745295) 1 NC_012967.1 regulates several genes involved in the formate hydrogenlyase system; seems to prevent binding of FhlA transcriptional activator to the activator sequence of hyc operon; formate hydrogenlyase regulatory protein HycA 2745295 hycA 8178632 hycA Escherichia coli B str. REL606 formate hydrogenlyase regulatory protein HycA YP_003045764.1 2744834 R 413997 CDS YP_003045765.1 254162657 8179168 2745507..2745857 1 NC_012967.1 plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein 2745857 hypA 8179168 hypA Escherichia coli B str. REL606 hydrogenase nickel incorporation protein YP_003045765.1 2745507 D 413997 CDS YP_003045766.1 254162658 8176994 2745861..2746733 1 NC_012967.1 GTP hydrolase involved in nickel liganding into hydrogenases; hydrogenase nickel incorporation protein HypB 2746733 hypB 8176994 hypB Escherichia coli B str. REL606 hydrogenase nickel incorporation protein HypB YP_003045766.1 2745861 D 413997 CDS YP_003045767.1 254162659 8178633 2746724..2746996 1 NC_012967.1 HypC; accessory protein necessary for maturation of the hydrogenase isoforms 1, 2 and 3; forms a complex with HypD, HypE, and HypF proteins, which is the site of ligand biosynthesis and attachment to the iron atom of the NiFe site in the hydrogenase; hydrogenase assembly chaperone 2746996 hypC 8178633 hypC Escherichia coli B str. REL606 hydrogenase assembly chaperone YP_003045767.1 2746724 D 413997 CDS YP_003045768.1 254162660 8176995 2746996..2748117 1 NC_012967.1 similar to b2729; protein required for maturation of hydrogenase isozymes; HypD 2748117 hypD 8176995 hypD Escherichia coli B str. REL606 HypD YP_003045768.1 2746996 D 413997 CDS YP_003045769.1 254162661 8176996 2748156..2749124 1 NC_012967.1 similar to b2730; carbamoyl phosphate phosphatase, hydrogenase 3 maturation protein 2749124 hypE 8176996 hypE Escherichia coli B str. REL606 carbamoyl phosphate phosphatase, hydrogenase 3 maturation protein YP_003045769.1 2748156 D 413997 CDS YP_003045770.1 254162662 8176997 2749198..2751276 1 NC_012967.1 similar to b2731; DNA-binding transcriptional activator 2751276 fhlA 8176997 fhlA Escherichia coli B str. REL606 DNA-binding transcriptional activator YP_003045770.1 2749198 D 413997 CDS YP_003045771.1 254162663 8179169 complement(2751313..2751666) 1 NC_012967.1 similar to b2732; hypothetical protein 2751666 ygbA 8179169 ygbA Escherichia coli B str. REL606 hypothetical protein YP_003045771.1 2751313 R 413997 CDS YP_003045772.1 254162664 8176998 2751953..2754514 1 NC_012967.1 This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 2754514 mutS 8176998 mutS Escherichia coli B str. REL606 DNA mismatch repair protein MutS YP_003045772.1 2751953 D 413997 CDS YP_003045773.1 254162665 8176999 2754620..2755276 1 NC_012967.1 similar to b2734; serine/threonine-specific protein phosphatase 2 2755276 pphB 8176999 pphB Escherichia coli B str. REL606 serine/threonine-specific protein phosphatase 2 YP_003045773.1 2754620 D 413997 CDS YP_003045774.1 254162666 8177000 complement(2755327..2756124) 1 NC_012967.1 similar to b2735; putative DNA-binding transcriptional regulator 2756124 ygbI 8177000 ygbI Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003045774.1 2755327 R 413997 CDS YP_003045775.1 254162667 8177001 2756290..2757198 1 NC_012967.1 similar to b2736; putative dehydrogenase, with NAD(P)-binding Rossmann-fold domain 2757198 ygbJ 8177001 ygbJ Escherichia coli B str. REL606 putative dehydrogenase, with NAD(P)-binding Rossmann-fold domain YP_003045775.1 2756290 D 413997 CDS YP_003045776.1 254162668 8177002 2757195..2758457 1 NC_012967.1 similar to b2737; hypothetical protein 2758457 ygbK 8177002 ygbK Escherichia coli B str. REL606 hypothetical protein YP_003045776.1 2757195 D 413997 CDS YP_003045777.1 254162669 8177003 2758454..2759092 1 NC_012967.1 similar to b2738; putative aldolase 2759092 ygbL 8177003 ygbL Escherichia coli B str. REL606 putative aldolase YP_003045777.1 2758454 D 413997 CDS YP_003045778.1 254162670 8179170 2759097..2759873 1 NC_012967.1 similar to b2739; hypothetical protein 2759873 ygbM 8179170 ygbM Escherichia coli B str. REL606 hypothetical protein YP_003045778.1 2759097 D 413997 CDS YP_003045779.1 254162671 8177004 2759962..2761326 1 NC_012967.1 member of the Gnt family of gluconate transporters; not involved in gluconate transport; unknown function; inner membrane permease YgbN 2761326 ygbN 8177004 ygbN Escherichia coli B str. REL606 inner membrane permease YgbN YP_003045779.1 2759962 D 413997 CDS YP_003045780.1 254162672 8177005 complement(2761420..2762412) 1 NC_012967.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor controls a regulon of genes required for protection against external stresses; RNA polymerase sigma factor RpoS 2762412 rpoS 8177005 rpoS Escherichia coli B str. REL606 RNA polymerase sigma factor RpoS YP_003045780.1 2761420 R 413997 CDS YP_003045781.1 254162673 8177006 complement(2762475..2763614) 1 NC_012967.1 outer membrane lipoprotein involved in stationary-phase cell survival; similar to LppB virulence determinant from Haemophilus somnus; lipoprotein NlpD 2763614 nlpD 8177006 nlpD Escherichia coli B str. REL606 lipoprotein NlpD YP_003045781.1 2762475 R 413997 CDS YP_003045782.1 254162674 8177007 complement(2763754..2764380) 1 NC_012967.1 catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins; protein-L-isoaspartate O-methyltransferase 2764380 pcm 8177007 pcm Escherichia coli B str. REL606 protein-L-isoaspartate O-methyltransferase YP_003045782.1 2763754 R 413997 CDS YP_003045783.1 254162675 8177008 complement(2764374..2765135) 1 NC_012967.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate; stationary phase survival protein SurE 2765135 surE 8177008 surE Escherichia coli B str. REL606 stationary phase survival protein SurE YP_003045783.1 2764374 R 413997 CDS YP_003045784.1 254162676 8178634 complement(2765116..2766165) 1 NC_012967.1 catalyzes the modification of U13 in tRNA(Glu); tRNA pseudouridine synthase D 2766165 truD 8178634 truD Escherichia coli B str. REL606 tRNA pseudouridine synthase D YP_003045784.1 2765116 R 413997 CDS YP_003045785.1 254162677 8177009 complement(2766162..2766641) 1 NC_012967.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 2766641 ispF 8177009 ispF Escherichia coli B str. REL606 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase YP_003045785.1 2766162 R 413997 CDS YP_003045786.1 254162678 8177010 complement(2766641..2767351) 1 NC_012967.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 2767351 ispD 8177010 ispD Escherichia coli B str. REL606 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase YP_003045786.1 2766641 R 413997 CDS YP_003045787.1 254162679 8177011 complement(2767370..2767681) 1 NC_012967.1 forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein; cell division protein FtsB 2767681 ftsB 8177011 ftsB Escherichia coli B str. REL606 cell division protein FtsB YP_003045787.1 2767370 R 413997 CDS YP_003045788.1 254162680 8177012 complement(2767875..2768198) 1 NC_012967.1 similar to b2749; hypothetical protein 2768198 ygbE 8177012 ygbE Escherichia coli B str. REL606 hypothetical protein YP_003045788.1 2767875 R 413997 CDS YP_003045789.1 254162681 8177013 complement(2768248..2768853) 1 NC_012967.1 converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis; adenylylsulfate kinase 2768853 cysC 8177013 cysC Escherichia coli B str. REL606 adenylylsulfate kinase YP_003045789.1 2768248 R 413997 CDS YP_003045790.1 254162682 8177014 complement(2768853..2770280) 1 NC_012967.1 may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ; sulfate adenylyltransferase subunit 1 2770280 cysN 8177014 cysN Escherichia coli B str. REL606 sulfate adenylyltransferase subunit 1 YP_003045790.1 2768853 R 413997 CDS YP_003045791.1 254162683 8178635 complement(2770282..2771190) 1 NC_012967.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; sulfate adenylyltransferase subunit 2 2771190 cysD 8178635 cysD Escherichia coli B str. REL606 sulfate adenylyltransferase subunit 2 YP_003045791.1 2770282 R 413997 CDS YP_003045792.1 254162684 8177015 2771442..2772479 1 NC_012967.1 catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3; alkaline phosphatase isozyme conversion aminopeptidase 2772479 iap 8177015 iap Escherichia coli B str. REL606 alkaline phosphatase isozyme conversion aminopeptidase YP_003045792.1 2771442 D 413997 CDS YP_003045793.1 254162685 8179171 2772911..2774023 1 NC_012967.1 putative transposase insL for insertion sequence IS186 2774023 insL-5 8179171 insL-5 Escherichia coli B str. REL606 putative transposase insL for insertion sequence IS186 YP_003045793.1 2772911 D 413997 CDS YP_003045794.1 254162686 8179172 complement(2774461..2775312) 1 NC_012967.1 IS150 putative transposase 2775312 insK-3 8179172 insK-3 Escherichia coli B str. REL606 IS150 putative transposase YP_003045794.1 2774461 R 413997 CDS YP_003045795.1 254162687 8177016 complement(2775309..2775830) 1 NC_012967.1 IS150 transposase A 2775830 insJ-3 8177016 insJ-3 Escherichia coli B str. REL606 IS150 transposase A YP_003045795.1 2775309 R 413997 CDS YP_003045796.1 254162688 8179173 complement(2776079..2776813) 1 NC_012967.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite; phosphoadenosine phosphosulfate reductase 2776813 cysH 8179173 cysH Escherichia coli B str. REL606 phosphoadenosine phosphosulfate reductase YP_003045796.1 2776079 R 413997 CDS YP_003045797.1 254162689 8177017 complement(2776887..2778599) 1 NC_012967.1 hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide; sulfite reductase subunit beta 2778599 cysI 8177017 cysI Escherichia coli B str. REL606 sulfite reductase subunit beta YP_003045797.1 2776887 R 413997 CDS YP_003045798.1 254162690 8177018 complement(2778599..2780398) 1 NC_012967.1 catalyzes the reduction of sulfite to sulfide in the biosynthesis of L-cysteine from sulfate; a flavoprotein with flavin reductase activity; sulfite reductase subunit alpha 2780398 cysJ 8177018 cysJ Escherichia coli B str. REL606 sulfite reductase subunit alpha YP_003045798.1 2778599 R 413997 CDS YP_003045799.1 254162691 8177019 2780714..2781079 1 NC_012967.1 similar to b2765; 6-pyruvoyl tetrahydrobiopterin synthase 2781079 ygcM 8177019 ygcM Escherichia coli B str. REL606 6-pyruvoyl tetrahydrobiopterin synthase YP_003045799.1 2780714 D 413997 CDS YP_003045800.1 254162692 8178636 2781157..2782428 1 NC_012967.1 similar to b2766; putative oxidoreductase with FAD/NAD(P)-binding domain 2782428 ygcN 8178636 ygcN Escherichia coli B str. REL606 putative oxidoreductase with FAD/NAD(P)-binding domain YP_003045800.1 2781157 D 413997 CDS YP_003045801.1 254162693 8177020 2782419..2782679 1 NC_012967.1 similar to b2767; putative 4Fe-4S cluster-containing protein 2782679 ygcO 8177020 ygcO Escherichia coli B str. REL606 putative 4Fe-4S cluster-containing protein YP_003045801.1 2782419 D 413997 CDS YP_003045802.1 254162694 8177021 2782696..2783271 1 NC_012967.1 similar to b2768; putative anti-terminator regulatory protein 2783271 ygcP 8177021 ygcP Escherichia coli B str. REL606 putative anti-terminator regulatory protein YP_003045802.1 2782696 D 413997 CDS YP_003045803.1 254162695 8177022 complement(2783419..2784279) 1 NC_012967.1 similar to b2769; putative flavoprotein 2784279 ygcQ 8177022 ygcQ Escherichia coli B str. REL606 putative flavoprotein YP_003045803.1 2783419 R 413997 CDS YP_003045804.1 254162696 8177023 complement(2784276..2785055) 1 NC_012967.1 similar to b2770; putative flavoprotein 2785055 ygcR 8177023 ygcR Escherichia coli B str. REL606 putative flavoprotein YP_003045804.1 2784276 R 413997 CDS YP_003045805.1 254162697 8177024 complement(2785033..2786370) 1 NC_012967.1 similar to b2771; putative transporter 2786370 ygcS 8177024 ygcS Escherichia coli B str. REL606 putative transporter YP_003045805.1 2785033 R 413997 CDS YP_003045806.1 254162698 8177025 complement(2786464..2787918) 1 NC_012967.1 similar to b4463; putative FAD containing dehydrogenase 2787918 ygcU 8177025 ygcU Escherichia coli B str. REL606 putative FAD containing dehydrogenase YP_003045806.1 2786464 R 413997 CDS YP_003045807.1 254162699 8178637 complement(2787988..2788773) 1 NC_012967.1 similar to b2774; putative deoxygluconate dehydrogenase 2788773 ygcW 8178637 ygcW Escherichia coli B str. REL606 putative deoxygluconate dehydrogenase YP_003045807.1 2787988 R 413997 CDS YP_003045808.1 254162700 8177026 2789092..2790369 1 NC_012967.1 similar to b2775; putative transporter 2790369 yqcE 8177026 yqcE Escherichia coli B str. REL606 putative transporter YP_003045808.1 2789092 D 413997 CDS YP_003045809.1 254162701 8177027 2790396..2791874 1 NC_012967.1 similar to b2776; putative kinase 2791874 ygcE 8177027 ygcE Escherichia coli B str. REL606 putative kinase YP_003045809.1 2790396 D 413997 CDS YP_003045811.1 254162703 8177029 complement(2793675..2794346) 1 NC_012967.1 similar to b2777; hypothetical protein 2794346 ygcF 8177029 ygcF Escherichia coli B str. REL606 hypothetical protein YP_003045811.1 2793675 R 413997 CDS YP_003045812.1 254162704 8177030 2794639..2795511 1 NC_012967.1 similar to b2778; hypothetical protein 2795511 ygcG 8177030 ygcG Escherichia coli B str. REL606 hypothetical protein YP_003045812.1 2794639 D 413997 CDS YP_003045813.1 254162705 8178638 complement(2795571..2796869) 1 NC_012967.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 2796869 eno 8178638 eno Escherichia coli B str. REL606 phosphopyruvate hydratase YP_003045813.1 2795571 R 413997 CDS YP_003045814.1 254162706 8177031 complement(2796957..2798594) 1 NC_012967.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 2798594 pyrG 8177031 pyrG Escherichia coli B str. REL606 CTP synthetase YP_003045814.1 2796957 R 413997 CDS YP_003045815.1 254162707 8177032 complement(2798822..2799613) 1 NC_012967.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era; nucleoside triphosphate pyrophosphohydrolase 2799613 mazG 8177032 mazG Escherichia coli B str. REL606 nucleoside triphosphate pyrophosphohydrolase YP_003045815.1 2798822 R 413997 CDS YP_003045816.1 254162708 8177033 complement(2799684..2800019) 1 NC_012967.1 MazF; endoribonuclease; toxin of the ChpA-ChpR toxin-antitoxin system; toxin ChpA 2800019 chpA 8177033 chpA Escherichia coli B str. REL606 toxin ChpA YP_003045816.1 2799684 R 413997 CDS YP_003045817.1 254162709 8177034 complement(2800019..2800267) 1 NC_012967.1 part of the MazF-MazE toxin-antitoxin system; conteracts MazF; antitoxin MazE 2800267 chpR 8177034 chpR Escherichia coli B str. REL606 antitoxin MazE YP_003045817.1 2800019 R 413997 CDS YP_003045818.1 254162710 8177035 complement(2800345..2802579) 1 NC_012967.1 (p)ppGpp synthetase; catalyzes the formation of pppGpp and ppGpp from ATP and GTP or GDP; GDP/GTP pyrophosphokinase 2802579 relA 8177035 relA Escherichia coli B str. REL606 GDP/GTP pyrophosphokinase YP_003045818.1 2800345 R 413997 CDS YP_003045819.1 254162711 8178639 complement(2802627..2803928) 1 NC_012967.1 in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]; 23S rRNA 5-methyluridine methyltransferase 2803928 rumA 8178639 rumA Escherichia coli B str. REL606 23S rRNA 5-methyluridine methyltransferase YP_003045819.1 2802627 R 413997 CDS YP_003045820.1 254162712 8177036 2803985..2806741 1 NC_012967.1 part of the two-component regulatory system with UvrY; involved in the regulation of carbon metabolism via the csrA/csrB regulatory system; hybrid sensory histidine kinase BarA 2806741 barA 8177036 barA Escherichia coli B str. REL606 hybrid sensory histidine kinase BarA YP_003045820.1 2803985 D 413997 CDS YP_003045821.1 254162713 8179174 complement(2806974..2808314) 1 NC_012967.1 similar to b2787; (D)-glucarate dehydratase 1 2808314 gudD 8179174 gudD Escherichia coli B str. REL606 (D)-glucarate dehydratase 1 YP_003045821.1 2806974 R 413997 CDS YP_003045822.1 254162714 8179175 complement(2808335..2809675) 1 NC_012967.1 similar to b2788; putative glucarate dehydratase 2809675 gudX 8179175 gudX Escherichia coli B str. REL606 putative glucarate dehydratase YP_003045822.1 2808335 R 413997 CDS YP_003045823.1 254162715 8177037 complement(2809677..2811029) 1 NC_012967.1 similar to b2789; putative D-glucarate transporter 2811029 gudP 8177037 gudP Escherichia coli B str. REL606 putative D-glucarate transporter YP_003045823.1 2809677 R 413997 CDS YP_003045824.1 254162716 8178640 complement(2811464..2811913) 1 NC_012967.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin 2811913 yqcA 8178640 yqcA Escherichia coli B str. REL606 flavodoxin YP_003045824.1 2811464 R 413997 CDS YP_003045825.1 254162717 8177038 complement(2811931..2812713) 1 NC_012967.1 catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp; tRNA pseudouridine synthase C 2812713 yqcB 8177038 yqcB Escherichia coli B str. REL606 tRNA pseudouridine synthase C YP_003045825.1 2811931 R 413997 CDS YP_003045826.1 254162718 8177039 complement(2812713..2813042) 1 NC_012967.1 similar to b2792; hypothetical protein 2813042 yqcC 8177039 yqcC Escherichia coli B str. REL606 hypothetical protein YP_003045826.1 2812713 R 413997 CDS YP_003045827.1 254162719 8177040 complement(2813664..2814209) 1 NC_012967.1 putative SecY regulator that either chelates excess SecY or negatively regulates the SecYE translocase function; SecY interacting protein Syd 2814209 syd 8177040 syd Escherichia coli B str. REL606 SecY interacting protein Syd YP_003045827.1 2813664 R 413997 CDS YP_003045828.1 254162720 8177041 2814277..2815125 1 NC_012967.1 catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 2815125 queF 8177041 queF Escherichia coli B str. REL606 7-cyano-7-deazaguanine reductase YP_003045828.1 2814277 D 413997 CDS YP_003045829.1 254162721 8177042 2815237..2816601 1 NC_012967.1 similar to b2795; hypothetical protein 2816601 ygdH 8177042 ygdH Escherichia coli B str. REL606 hypothetical protein YP_003045829.1 2815237 D 413997 CDS YP_003045830.1 254162722 8177043 2817158..2818447 1 NC_012967.1 similar to b2796; putative serine transporter 2818447 sdaC 8177043 sdaC Escherichia coli B str. REL606 putative serine transporter YP_003045830.1 2817158 D 413997 CDS YP_003045831.1 254162723 8178641 2818505..2819872 1 NC_012967.1 similar to b2797; L-serine deaminase II 2819872 sdaB 8178641 sdaB Escherichia coli B str. REL606 L-serine deaminase II YP_003045831.1 2818505 D 413997 CDS YP_003045832.1 254162724 8179176 2819894..2820739 1 NC_012967.1 has 3'-5' exonuclease activity that preferentially acts on ssDNA; also 3'-phosphodiesterase activity at sites with 3' incised apurinic/apyrimidinic sites; can remove 3' phosphoglycolate groups; exonuclease IX 2820739 xni 8179176 xni Escherichia coli B str. REL606 exonuclease IX YP_003045832.1 2819894 D 413997 CDS YP_003045833.1 254162725 8177044 complement(2820794..2821945) 1 NC_012967.1 similar to b2799; L-1,2-propanediol oxidoreductase 2821945 fucO 8177044 fucO Escherichia coli B str. REL606 L-1,2-propanediol oxidoreductase YP_003045833.1 2820794 R 413997 CDS YP_003045834.1 254162726 8177046 complement(2822202..2822705) 1 NC_012967.1 IS1 protein InsB 2822705 insB-21 8177046 insB-21 Escherichia coli B str. REL606 IS1 protein InsB YP_003045834.1 2822202 R 413997 CDS YP_003045835.1 254162727 8177047 complement(2822624..2822899) 1 NC_012967.1 IS1 protein InsA 2822899 insA-21 8177047 insA-21 Escherichia coli B str. REL606 IS1 protein InsA YP_003045835.1 2822624 R 413997 CDS YP_003045836.1 254162728 8177048 complement(2823527..2824471) 1 NC_012967.1 L-fuculose phosphate aldolase 2824471 8177048 ECB_02648 Escherichia coli B str. REL606 L-fuculose phosphate aldolase YP_003045836.1 2823527 R 413997 CDS YP_003045837.1 254162729 8177049 complement(2824590..2826218) 1 NC_012967.1 L-ribulokinase AraB-like protein 2826218 8177049 ECB_02649 Escherichia coli B str. REL606 L-ribulokinase AraB-like protein YP_003045837.1 2824590 R 413997 CDS YP_003045838.1 254162730 8177050 complement(2826223..2827296) 1 NC_012967.1 D-ribose-binding periplasmic protein 2827296 8177050 ECB_02650 Escherichia coli B str. REL606 D-ribose-binding periplasmic protein YP_003045838.1 2826223 R 413997 CDS YP_003045839.1 254162731 8177051 complement(2827247..2828230) 1 NC_012967.1 Ribose transport system permease rbsC 2828230 8177051 ECB_02651 Escherichia coli B str. REL606 Ribose transport system permease rbsC YP_003045839.1 2827247 R 413997 CDS YP_003045840.1 254162732 8177052 complement(2828234..2829733) 1 NC_012967.1 hypothetical protein 2829733 8177052 ECB_02652 Escherichia coli B str. REL606 hypothetical protein YP_003045840.1 2828234 R 413997 CDS YP_003045841.1 254162733 8177053 2830203..2831978 1 NC_012967.1 catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose; L-fucose isomerase 2831978 fucI 8177053 fucI Escherichia coli B str. REL606 L-fucose isomerase YP_003045841.1 2830203 D 413997 CDS YP_003045842.1 254162734 8178642 2832057..2833505 1 NC_012967.1 similar to b2803; L-fuculokinase 2833505 fucK 8178642 fucK Escherichia coli B str. REL606 L-fuculokinase YP_003045842.1 2832057 D 413997 CDS YP_003045843.1 254162735 8177054 2833507..2833929 1 NC_012967.1 similar to b2804; L-fucose mutarotase 2833929 fucU 8177054 fucU Escherichia coli B str. REL606 L-fucose mutarotase YP_003045843.1 2833507 D 413997 CDS YP_003045844.1 254162736 8179177 2833987..2834718 1 NC_012967.1 regulates expression of genes involved in L-fucose utilization; DNA-binding transcriptional activator FucR 2834718 fucR 8179177 fucR Escherichia coli B str. REL606 DNA-binding transcriptional activator FucR YP_003045844.1 2833987 D 413997 CDS YP_003045845.1 254162737 8179178 complement(2834762..2835862) 1 NC_012967.1 similar to b2806; putative RNA 2'-O-ribose methyltransferase 2835862 ygdE 8179178 ygdE Escherichia coli B str. REL606 putative RNA 2'-O-ribose methyltransferase YP_003045845.1 2834762 R 413997 CDS YP_003045846.1 254162738 8177055 complement(2835855..2836250) 1 NC_012967.1 similar to b2807; hypothetical protein 2836250 ygdD 8177055 ygdD Escherichia coli B str. REL606 hypothetical protein YP_003045846.1 2835855 R 413997 CDS YP_003045847.1 254162739 8177056 complement(2836269..2837186) 1 NC_012967.1 Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence; DNA-binding transcriptional activator GcvA 2837186 gcvA 8177056 gcvA Escherichia coli B str. REL606 DNA-binding transcriptional activator GcvA YP_003045847.1 2836269 R 413997 CDS YP_003045848.1 254162740 8177057 complement(2837537..2837764) 1 NC_012967.1 similar to b2809; hypothetical protein 2837764 ygdI 8177057 ygdI Escherichia coli B str. REL606 hypothetical protein YP_003045848.1 2837537 R 413997 CDS YP_003045849.1 254162741 8177058 2837956..2839161 1 NC_012967.1 similar to b2810; cysteine sulfinate desulfinase 2839161 csdA 8177058 csdA Escherichia coli B str. REL606 cysteine sulfinate desulfinase YP_003045849.1 2837956 D 413997 CDS YP_003045850.1 254162742 8177059 2839161..2839604 1 NC_012967.1 similar to b2811; putative Fe-S metabolism protein 2839604 ygdK 8177059 ygdK Escherichia coli B str. REL606 putative Fe-S metabolism protein YP_003045850.1 2839161 D 413997 CDS YP_003045851.1 254162743 8178643 complement(2839655..2840461) 1 NC_012967.1 similar to b2812; hypothetical protein 2840461 ygdL 8178643 ygdL Escherichia coli B str. REL606 hypothetical protein YP_003045851.1 2839655 R 413997 CDS YP_003045852.1 254162744 8177060 complement(2840700..2841797) 1 NC_012967.1 membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase A 2841797 mltA 8177060 mltA Escherichia coli B str. REL606 murein transglycosylase A YP_003045852.1 2840700 R 413997 CDS YP_003045853.1 254162745 8177064 complement(2842376..2843629) 1 NC_012967.1 similar to b2817; N-acetylmuramoyl-L-alanine amidase 2843629 amiC 8177064 amiC Escherichia coli B str. REL606 N-acetylmuramoyl-L-alanine amidase YP_003045853.1 2842376 R 413997 CDS YP_003045854.1 254162746 8177065 2843861..2845192 1 NC_012967.1 catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; N-acetylglutamate synthase 2845192 argA 8177065 argA Escherichia coli B str. REL606 N-acetylglutamate synthase YP_003045854.1 2843861 D 413997 CDS YP_003045855.1 254162747 8179179 complement(2845254..2847080) 1 NC_012967.1 helicase/nuclease; with RecBC catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit alpha 2847080 recD 8179179 recD Escherichia coli B str. REL606 exonuclease V subunit alpha YP_003045855.1 2845254 R 413997 CDS YP_003045856.1 254162748 8177066 complement(2847080..2850622) 1 NC_012967.1 helicase/nuclease; with RecCD catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit beta 2850622 recB 8177066 recB Escherichia coli B str. REL606 exonuclease V subunit beta YP_003045856.1 2847080 R 413997 CDS YP_003045857.1 254162749 8179180 complement(2850615..2853503) 1 NC_012967.1 similar to b2821; protease III 2853503 ptr 8179180 ptr Escherichia coli B str. REL606 protease III YP_003045857.1 2850615 R 413997 CDS YP_003045858.1 254162750 8179181 complement(2853679..2857047) 1 NC_012967.1 catalyzes ATP-dependent exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides; component of the RecBCD (Exo V) helicase/nuclease complex that is essential for recombination; exonuclease V subunit gamma 2857047 recC 8179181 recC Escherichia coli B str. REL606 exonuclease V subunit gamma YP_003045858.1 2853679 R 413997 CDS YP_003045859.1 254162751 8177067 complement(2857060..2857383) 1 NC_012967.1 similar to b2823; hypothetical protein 2857383 ppdC 8177067 ppdC Escherichia coli B str. REL606 hypothetical protein YP_003045859.1 2857060 R 413997 CDS YP_003045860.1 254162752 8177068 complement(2857368..2857775) 1 NC_012967.1 similar to b2824; hypothetical protein 2857775 ygdB 8177068 ygdB Escherichia coli B str. REL606 hypothetical protein YP_003045860.1 2857368 R 413997 CDS YP_003045861.1 254162753 8177069 complement(2857772..2858335) 1 NC_012967.1 similar to b2825; hypothetical protein 2858335 ppdB 8177069 ppdB Escherichia coli B str. REL606 hypothetical protein YP_003045861.1 2857772 R 413997 CDS YP_003045862.1 254162754 8177070 complement(2858326..2858796) 1 NC_012967.1 similar to b2826; hypothetical protein 2858796 ppdA 8177070 ppdA Escherichia coli B str. REL606 hypothetical protein YP_003045862.1 2858326 R 413997 CDS YP_003045863.1 254162755 8177071 complement(2858981..2859775) 1 NC_012967.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 2859775 thyA 8177071 thyA Escherichia coli B str. REL606 thymidylate synthase YP_003045863.1 2858981 R 413997 CDS YP_003045864.1 254162756 8177072 complement(2859782..2860657) 1 NC_012967.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 2860657 lgt 8177072 lgt Escherichia coli B str. REL606 prolipoprotein diacylglyceryl transferase YP_003045864.1 2859782 R 413997 CDS YP_003045865.1 254162757 8179182 complement(2860808..2863054) 1 NC_012967.1 member of a second PTS chain involved in nitrogen metabolism; PtsP phosphorylates NPr; fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain 2863054 ptsP 8179182 ptsP Escherichia coli B str. REL606 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain YP_003045865.1 2860808 R 413997 CDS YP_003045866.1 254162758 8177073 complement(2863067..2863597) 1 NC_012967.1 hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase 2863597 ygdP 8177073 ygdP Escherichia coli B str. REL606 dinucleoside polyphosphate hydrolase YP_003045866.1 2863067 R 413997 CDS YP_003045867.1 254162759 8177074 2864282..2864971 1 NC_012967.1 MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair; DNA mismatch repair protein 2864971 mutH 8177074 mutH Escherichia coli B str. REL606 DNA mismatch repair protein YP_003045867.1 2864282 D 413997 CDS YP_003045868.1 254162760 8177075 2865040..2865753 1 NC_012967.1 similar to b2832; putative inner membrane protein 2865753 ygdQ 8177075 ygdQ Escherichia coli B str. REL606 putative inner membrane protein YP_003045868.1 2865040 D 413997 CDS YP_003045869.1 254162761 8177076 2865891..2866109 1 NC_012967.1 similar to b2833; hypothetical protein 2866109 ygdR 8177076 ygdR Escherichia coli B str. REL606 hypothetical protein YP_003045869.1 2865891 D 413997 CDS YP_003045870.1 254162762 8177077 2866217..2867257 1 NC_012967.1 complements the prephenate dehydrogenase dysfunction of an Escherichia coli tyrosine auxotroph strain; member of the aldo/keto reductase 2 family; crystal structure of purified Escherichia coli protein shows bound NADPH; putative aldo-keto reductase 2867257 tas 8177077 tas Escherichia coli B str. REL606 putative aldo-keto reductase YP_003045870.1 2866217 D 413997 CDS YP_003045871.1 254162763 8177078 complement(2867289..2868482) 1 NC_012967.1 similar to b2835; lysophospholipid transporter LplT 2868482 ygeD 8177078 ygeD Escherichia coli B str. REL606 lysophospholipid transporter LplT YP_003045871.1 2867289 R 413997 CDS YP_003045872.1 254162764 8177079 complement(2868475..2870634) 1 NC_012967.1 Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase 2870634 aas 8177079 aas Escherichia coli B str. REL606 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase YP_003045872.1 2868475 R 413997 CDS YP_003045873.1 254162765 8178644 2871220..2872251 1 NC_012967.1 controls transcription of galETKM; DNA-binding transcriptional regulator GalR 2872251 galR 8178644 galR Escherichia coli B str. REL606 DNA-binding transcriptional regulator GalR YP_003045873.1 2871220 D 413997 CDS YP_003045874.1 254162766 8177080 complement(2872258..2873520) 1 NC_012967.1 catalyzes the decarboxylation of diaminopimelate into lysine; pyridoxal phosphate(PLP)-binding; diaminopimelate decarboxylase 2873520 lysA 8177080 lysA Escherichia coli B str. REL606 diaminopimelate decarboxylase YP_003045874.1 2872258 R 413997 CDS YP_003045875.1 254162767 8178645 2873642..2874577 1 NC_012967.1 activates the transcription of the lysA gene encoding diaminopimelate decarboxylase; DNA-binding transcriptional regulator LysR 2874577 lysR 8178645 lysR Escherichia coli B str. REL606 DNA-binding transcriptional regulator LysR YP_003045875.1 2873642 D 413997 CDS YP_003045876.1 254162768 8177081 complement(2874564..2875256) 1 NC_012967.1 similar to b2840; putative racemase 2875256 ygeA 8177081 ygeA Escherichia coli B str. REL606 putative racemase YP_003045876.1 2874564 R 413997 CDS YP_003045877.1 254162769 8177082 complement(2875385..2876803) 1 NC_012967.1 similar to b2841; arabinose transporter 2876803 araE 8177082 araE Escherichia coli B str. REL606 arabinose transporter YP_003045877.1 2875385 R 413997 CDS YP_003045878.1 254162770 8178646 complement(2877118..2877879) 1 NC_012967.1 catalyzes the formation of 3-dehydro-2-deoxy-D-gluconate from 2-deoxy-D-gluconate; 2-deoxy-D-gluconate 3-dehydrogenase 2877879 kduD 8178646 kduD Escherichia coli B str. REL606 2-deoxy-D-gluconate 3-dehydrogenase YP_003045878.1 2877118 R 413997 CDS YP_003045879.1 254162771 8177083 complement(2877909..2878745) 1 NC_012967.1 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate; 5-keto-4-deoxyuronate isomerase 2878745 kduI 8177083 kduI Escherichia coli B str. REL606 5-keto-4-deoxyuronate isomerase YP_003045879.1 2877909 R 413997 CDS YP_003045880.1 254162772 8177084 complement(2879032..2880213) 1 NC_012967.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis; acetyl-CoA acetyltransferase 2880213 yqeF 8177084 yqeF Escherichia coli B str. REL606 acetyl-CoA acetyltransferase YP_003045880.1 2879032 R 413997 CDS YP_003045881.1 254162773 8177085 2880469..2881698 1 NC_012967.1 similar to b2845; putative transporter 2881698 yqeG 8177085 yqeG Escherichia coli B str. REL606 putative transporter YP_003045881.1 2880469 D 413997 CDS YP_003045882.1 254162774 8177086 2882158..2882727 1 NC_012967.1 similar to b2846; hypothetical protein 2882727 yqeH 8177086 yqeH Escherichia coli B str. REL606 hypothetical protein YP_003045882.1 2882158 D 413997 CDS YP_003045883.1 254162775 8177087 2882765..2883073 1 NC_012967.1 putative transposase-related protein 2883073 insE-5 8177087 insE-5 Escherichia coli B str. REL606 putative transposase-related protein YP_003045883.1 2882765 D 413997 CDS YP_003045884.1 254162776 8177088 2883130..2883936 1 NC_012967.1 putative transposase for IS3 2883936 insF-5 8177088 insF-5 Escherichia coli B str. REL606 putative transposase for IS3 YP_003045884.1 2883130 D 413997 CDS YP_003045885.1 254162777 8178647 complement(2883950..2884501) 1 NC_012967.1 similar to b2863; hypothetical protein 2884501 ygeQ 8178647 ygeQ Escherichia coli B str. REL606 hypothetical protein YP_003045885.1 2883950 R 413997 CDS YP_003045886.1 254162778 8178648 complement(2884891..2885646) 1 NC_012967.1 similar to b2865; Tetratricopeptide repeat transcriptional regulator 2885646 ygeR 8178648 ygeR Escherichia coli B str. REL606 Tetratricopeptide repeat transcriptional regulator YP_003045886.1 2884891 R 413997 CDS YP_003045887.1 254162779 8177090 2886100..2888358 1 NC_012967.1 putative molybdenum cofactor-binding protein; participates in purine salvage; xanthine dehydrogenase subunit XdhA 2888358 xdhA 8177090 xdhA Escherichia coli B str. REL606 xanthine dehydrogenase subunit XdhA YP_003045887.1 2886100 D 413997 CDS YP_003045888.1 254162780 8177091 2888369..2889247 1 NC_012967.1 FAD-binding subunit; with XdhA and XdhC participates in purine salvage; xanthine dehydrogenase subunit XdhB 2889247 xdhB 8177091 xdhB Escherichia coli B str. REL606 xanthine dehydrogenase subunit XdhB YP_003045888.1 2888369 D 413997 CDS YP_003045889.1 254162781 8178649 2889244..2889723 1 NC_012967.1 iron-sulfur-binding subunit; with XdhA and XdhB participates in purine salvage; xanthine dehydrogenase subunit XdhC 2889723 xdhC 8178649 xdhC Escherichia coli B str. REL606 xanthine dehydrogenase subunit XdhC YP_003045889.1 2889244 D 413997 CDS YP_003045890.1 254162782 8177092 complement(2889763..2891541) 1 NC_012967.1 similar to b2869; putative DNA-binding transcriptional regulator 2891541 ygeV 8177092 ygeV Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003045890.1 2889763 R 413997 CDS YP_003045891.1 254162783 8179183 2892017..2893207 1 NC_012967.1 similar to b2870; aspartate/ornithine carbamoyltransferase family protein 2893207 ygeW 8179183 ygeW Escherichia coli B str. REL606 aspartate/ornithine carbamoyltransferase family protein YP_003045891.1 2892017 D 413997 CDS YP_003045892.1 254162784 8177093 2893265..2894461 1 NC_012967.1 catalyzes the formation of pyruvate from 2,3-diaminopropionate; diaminopropionate ammonia-lyase 2894461 ygeX 8177093 ygeX Escherichia coli B str. REL606 diaminopropionate ammonia-lyase YP_003045892.1 2893265 D 413997 CDS YP_003045893.1 254162785 8177094 2894519..2895730 1 NC_012967.1 Zn-dependent extracellular dipeptidase; similar to succinyl-diaminopimelate desuccinylases; peptidase 2895730 ygeY 8177094 ygeY Escherichia coli B str. REL606 peptidase YP_003045893.1 2894519 D 413997 CDS YP_003045894.1 254162786 8177095 2895783..2897168 1 NC_012967.1 catalyzes the hydrolytic cleavage of hydantoin with aromatic side chains at the 5'position; phenylhydantoinase 2897168 ygeZ 8177095 ygeZ Escherichia coli B str. REL606 phenylhydantoinase YP_003045894.1 2895783 D 413997 CDS YP_003045895.1 254162787 8177096 2897216..2898148 1 NC_012967.1 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 2898148 yqeA 8177096 yqeA Escherichia coli B str. REL606 carbamate kinase YP_003045895.1 2897216 D 413997 CDS YP_003045896.1 254162788 8178650 complement(2898369..2899994) 1 NC_012967.1 similar to b2875; hypothetical protein 2899994 yqeB 8178650 yqeB Escherichia coli B str. REL606 hypothetical protein YP_003045896.1 2898369 R 413997 CDS YP_003045897.1 254162789 8177097 complement(2900042..2900812) 1 NC_012967.1 similar to b2876; hypothetical protein 2900812 yqeC 8177097 yqeC Escherichia coli B str. REL606 hypothetical protein YP_003045897.1 2900042 R 413997 CDS YP_003045898.1 254162790 8179184 2900915..2901493 1 NC_012967.1 similar to b2877; hypothetical protein 2901493 ygfJ 8179184 ygfJ Escherichia coli B str. REL606 hypothetical protein YP_003045898.1 2900915 D 413997 CDS YP_003045899.1 254162791 8177098 2901814..2904912 1 NC_012967.1 with YgfM and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfK mutants are unable to reduce selenate; involved in purine salvage process; seems to act as an oxidoreductase, but sequence similarity suggests it is a dihydrothymine dehydrogenase; putative selenate reductase subunit YgfK 2904912 ygfK 8177098 ygfK Escherichia coli B str. REL606 putative selenate reductase subunit YgfK YP_003045899.1 2901814 D 413997 CDS YP_003045900.1 254162792 8177099 2904915..2906243 1 NC_012967.1 in Escherichia coli expression is induced in response to phase-specific signals and controlled by RpoS; putative chlorohydrolase/aminohydrolase 2906243 ssnA 8177099 ssnA Escherichia coli B str. REL606 putative chlorohydrolase/aminohydrolase YP_003045900.1 2904915 D 413997 CDS YP_003045901.1 254162793 8178651 2906294..2907073 1 NC_012967.1 with YgfK and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfM contains a FAD domain; putative selenate reductase subunit YgfM 2907073 ygfM 8178651 ygfM Escherichia coli B str. REL606 putative selenate reductase subunit YgfM YP_003045901.1 2906294 D 413997 CDS YP_003045902.1 254162794 8177100 2907070..2909940 1 NC_012967.1 with YgfK and YgfM forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; molybdopterin-containing enzyme; oxidase activity toward hypoxanthine and xanthine can be detected if these substrates are present at high concentration; putative selenate reductase subunit YgfN 2909940 xdhD 8177100 xdhD Escherichia coli B str. REL606 putative selenate reductase subunit YgfN YP_003045902.1 2907070 D 413997 CDS YP_003045903.1 254162795 8179185 2910105..2911505 1 NC_012967.1 similar to b2882; putative transporter 2911505 ygfO 8179185 ygfO Escherichia coli B str. REL606 putative transporter YP_003045903.1 2910105 D 413997 CDS YP_003045904.1 254162796 8177101 2911520..2912839 1 NC_012967.1 Catalyzes the deamination of guanine; guanine deaminase 2912839 guaD 8177101 guaD Escherichia coli B str. REL606 guanine deaminase YP_003045904.1 2911520 D 413997 CDS YP_003045905.1 254162797 8177102 2912875..2914242 1 NC_012967.1 similar to b4464; putative transporter 2914242 ygfQ 8177102 ygfQ Escherichia coli B str. REL606 putative transporter YP_003045905.1 2912875 D 413997 CDS YP_003045906.1 254162798 8177103 complement(2914278..2914610) 1 NC_012967.1 similar to b2886; putative oxidoreductase, 4Fe-4S ferredoxin-type subunit 2914610 ygfS 8177103 ygfS Escherichia coli B str. REL606 putative oxidoreductase, 4Fe-4S ferredoxin-type subunit YP_003045906.1 2914278 R 413997 CDS YP_003045907.1 254162799 8177104 complement(2914766..2916685) 1 NC_012967.1 unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic); putative oxidoreductase Fe-S binding subunit 2916685 ygfT 8177104 ygfT Escherichia coli B str. REL606 putative oxidoreductase Fe-S binding subunit YP_003045907.1 2914766 R 413997 CDS YP_003045908.1 254162800 8179186 2917121..2918569 1 NC_012967.1 similar to b2888; putative transporter 2918569 ygfU 8179186 ygfU Escherichia coli B str. REL606 putative transporter YP_003045908.1 2917121 D 413997 CDS YP_003045909.1 254162801 8177105 2918819..2919367 1 NC_012967.1 catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate; isopentenyl-diphosphate delta-isomerase 2919367 idi 8177105 idi Escherichia coli B str. REL606 isopentenyl-diphosphate delta-isomerase YP_003045909.1 2918819 D 413997 CDS YP_003045910.1 254162802 8177106 complement(2919410..2920927) 1 NC_012967.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 2920927 lysS 8177106 lysS Escherichia coli B str. REL606 lysyl-tRNA synthetase YP_003045910.1 2919410 R 413997 CDS YP_003045911.1 254162803 8178652 complement(join(2920937..2921959,2921961..2922035)) 1 NC_012967.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 2922035 prfB 8178652 prfB Escherichia coli B str. REL606 peptide chain release factor 2 YP_003045911.1 2920937 R 413997 CDS YP_003045912.1 254162804 8177107 complement(2922126..2923859) 1 NC_012967.1 5'-3' single-stranded-DNA-specific exonuclease; ssDNA exonuclease RecJ 2923859 recJ 8177107 recJ Escherichia coli B str. REL606 ssDNA exonuclease RecJ YP_003045912.1 2922126 R 413997 CDS YP_003045913.1 254162805 8177108 complement(2923865..2924575) 1 NC_012967.1 DsbC; periplasmic protein with protein disulfide isomerase activity; this protein also shows disulfide oxidoreductase activity; thiol:disulfide interchange protein DsbC 2924575 dsbC 8177108 dsbC Escherichia coli B str. REL606 thiol:disulfide interchange protein DsbC YP_003045913.1 2923865 R 413997 CDS YP_003045914.1 254162806 8177109 complement(2924600..2925496) 1 NC_012967.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD 2925496 xerD 8177109 xerD Escherichia coli B str. REL606 site-specific tyrosine recombinase XerD YP_003045914.1 2924600 R 413997 CDS YP_003045915.1 254162807 8177110 2925608..2926129 1 NC_012967.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic; flavodoxin FldB 2926129 fldB 8177110 fldB Escherichia coli B str. REL606 flavodoxin FldB YP_003045915.1 2925608 D 413997 CDS YP_003045916.1 254162808 8178653 complement(2926169..2926576) 1 NC_012967.1 similar to b2896; hypothetical protein 2926576 ygfX 8178653 ygfX Escherichia coli B str. REL606 hypothetical protein YP_003045916.1 2926169 R 413997 CDS YP_003045917.1 254162809 8177111 complement(2926557..2926823) 1 NC_012967.1 similar to b2897; hypothetical protein 2926823 ygfY 8177111 ygfY Escherichia coli B str. REL606 hypothetical protein YP_003045917.1 2926557 R 413997 CDS YP_003045918.1 254162810 8179187 2927066..2928046 1 NC_012967.1 physiological role is not clear; not essential for growth but mutants grow poorly; mutations suppress hda null mutations; may be involved in regulation of ATP-DnaA levels; may also be involved in regulation of tRNA modifications; can bind folic acid and tetrahydrofolate; forms a three domain ring-like structure with a central channel; structurally similar to DMGO protein from A. globiformis; shows sequence similarity to yeast CAF17 transcriptional regulator; putative global regulator 2928046 ygfZ 8179187 ygfZ Escherichia coli B str. REL606 putative global regulator YP_003045918.1 2927066 D 413997 CDS YP_003045919.1 254162811 8177112 complement(2928242..2928901) 1 NC_012967.1 similar to b2899; putative oxidoreductase, inner membrane subunit 2928901 yqfA 8177112 yqfA Escherichia coli B str. REL606 putative oxidoreductase, inner membrane subunit YP_003045919.1 2928242 R 413997 CDS YP_003045920.1 254162812 8177113 complement(2929065..2929376) 1 NC_012967.1 similar to b2900; hypothetical protein 2929376 yqfB 8177113 yqfB Escherichia coli B str. REL606 hypothetical protein YP_003045920.1 2929065 R 413997 CDS YP_003045921.1 254162813 8179188 2929415..2930854 1 NC_012967.1 similar to b2901; 6-phospho-beta-glucosidase A 2930854 bglA 8179188 bglA Escherichia coli B str. REL606 6-phospho-beta-glucosidase A YP_003045921.1 2929415 D 413997 CDS YP_003045922.1 254162814 8177114 complement(2930911..2931654) 1 NC_012967.1 similar to b2902; hypothetical protein 2931654 ygfF 8177114 ygfF Escherichia coli B str. REL606 hypothetical protein YP_003045922.1 2930911 R 413997 CDS YP_003045923.1 254162815 8177115 complement(2931920..2934793) 1 NC_012967.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase 2934793 gcvP 8177115 gcvP Escherichia coli B str. REL606 glycine dehydrogenase YP_003045923.1 2931920 R 413997 CDS YP_003045924.1 254162816 8177116 complement(2934912..2935301) 1 NC_012967.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor; glycine cleavage system protein H 2935301 gcvH 8177116 gcvH Escherichia coli B str. REL606 glycine cleavage system protein H YP_003045924.1 2934912 R 413997 CDS YP_003045925.1 254162817 8177117 complement(2935325..2936419) 1 NC_012967.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T 2936419 gcvT 8177117 gcvT Escherichia coli B str. REL606 glycine cleavage system aminomethyltransferase T YP_003045925.1 2935325 R 413997 CDS YP_003045926.1 254162818 8177118 complement(2936866..2938068) 1 NC_012967.1 similar to b2906; hypothetical protein 2938068 visC 8177118 visC Escherichia coli B str. REL606 hypothetical protein YP_003045926.1 2936866 R 413997 CDS YP_003045927.1 254162819 8177119 complement(2938091..2939269) 1 NC_012967.1 Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone; 2-octaprenyl-6-methoxyphenyl hydroxylase 2939269 ubiH 8177119 ubiH Escherichia coli B str. REL606 2-octaprenyl-6-methoxyphenyl hydroxylase YP_003045927.1 2938091 R 413997 CDS YP_003045928.1 254162820 8179189 complement(2939266..2940591) 1 NC_012967.1 exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue; substrate can be as short as a dipeptide; proline aminopeptidase P II 2940591 pepP 8179189 pepP Escherichia coli B str. REL606 proline aminopeptidase P II YP_003045928.1 2939266 R 413997 CDS YP_003045929.1 254162821 8177120 complement(2940617..2941195) 1 NC_012967.1 the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown; hypothetical protein 2941195 ygfB 8177120 ygfB Escherichia coli B str. REL606 hypothetical protein YP_003045929.1 2940617 R 413997 CDS YP_003045930.1 254162822 8179190 2941363..2941692 1 NC_012967.1 similar to b2910; Z-ring-associated protein 2941692 ygfE 8179190 ygfE Escherichia coli B str. REL606 Z-ring-associated protein YP_003045930.1 2941363 D 413997 CDS YP_003045931.1 254162823 8177121 2941992..2942540 1 NC_012967.1 ygfA expression increases five to eight fold in Escherichia coli cells growing as biofilms; unknown function; putative ligase 2942540 ygfA 8177121 ygfA Escherichia coli B str. REL606 putative ligase YP_003045931.1 2941992 D 413997 CDS YP_003045932.1 254162824 8177122 complement(2942929..2944161) 1 NC_012967.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase 2944161 serA 8177122 serA Escherichia coli B str. REL606 D-3-phosphoglycerate dehydrogenase YP_003045932.1 2942929 R 413997 CDS YP_003045933.1 254162825 8179191 complement(2944417..2945076) 1 NC_012967.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 2945076 rpiA 8179191 rpiA Escherichia coli B str. REL606 ribose-5-phosphate isomerase A YP_003045933.1 2944417 R 413997 CDS YP_003045934.1 254162826 8177123 complement(2945132..2945362) 1 NC_012967.1 similar to b2915; hypothetical protein 2945362 yqfE 8177123 yqfE Escherichia coli B str. REL606 hypothetical protein YP_003045934.1 2945132 R 413997 CDS YP_003045935.1 254162827 8177124 2945504..2946397 1 NC_012967.1 specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport; chromosome replication initiation inhibitor protein 2946397 iciA 8177124 iciA Escherichia coli B str. REL606 chromosome replication initiation inhibitor protein YP_003045935.1 2945504 D 413997 CDS YP_003045936.1 254162828 8177125 2946601..2948745 1 NC_012967.1 MDM; functions in conversion of succinate to propionate; methylmalonyl-CoA mutase 2948745 sbm 8177125 sbm Escherichia coli B str. REL606 methylmalonyl-CoA mutase YP_003045936.1 2946601 D 413997 CDS YP_003045937.1 254162829 8177126 2948738..2949733 1 NC_012967.1 functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins; arginine/ornithine transport system ATPase 2949733 argK 8177126 argK Escherichia coli B str. REL606 arginine/ornithine transport system ATPase YP_003045937.1 2948738 D 413997 CDS YP_003045938.1 254162830 8178654 2949744..2950529 1 NC_012967.1 catalyzes the formation of propanoyl-CoA from methylmalonyl-CoA; methylmalonyl-CoA decarboxylase 2950529 ygfG 8178654 ygfG Escherichia coli B str. REL606 methylmalonyl-CoA decarboxylase YP_003045938.1 2949744 D 413997 CDS YP_003045939.1 254162831 8178655 2950553..2952031 1 NC_012967.1 similar to b2920; propionyl-CoA:succinate-CoA transferase 2952031 ygfH 8178655 ygfH Escherichia coli B str. REL606 propionyl-CoA:succinate-CoA transferase YP_003045939.1 2950553 D 413997 CDS YP_003045940.1 254162832 8177127 complement(2952028..2952924) 1 NC_012967.1 similar to b2921; putative DNA-binding transcriptional regulator 2952924 ygfI 8177127 ygfI Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003045940.1 2952028 R 413997 CDS YP_003045941.1 254162833 8177128 complement(2953091..2953831) 1 NC_012967.1 similar to b2922; hypothetical protein 2953831 yggE 8177128 yggE Escherichia coli B str. REL606 hypothetical protein YP_003045941.1 2953091 R 413997 CDS YP_003045942.1 254162834 8177129 complement(2953924..2954559) 1 NC_012967.1 Involved in the export of arginine; arginine exporter protein 2954559 yggA 8177129 yggA Escherichia coli B str. REL606 arginine exporter protein YP_003045942.1 2953924 R 413997 CDS YP_003045943.1 254162835 8178656 complement(2954698..2955558) 1 NC_012967.1 participates in the regulation of osmotic pressure changes within the cel; mechanosensitive channel MscS 2955558 yggB 8178656 yggB Escherichia coli B str. REL606 mechanosensitive channel MscS YP_003045943.1 2954698 R 413997 CDS YP_003045944.1 254162836 8177130 complement(2955916..2956995) 1 NC_012967.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 2956995 fbaA 8177130 fbaA Escherichia coli B str. REL606 fructose-bisphosphate aldolase YP_003045944.1 2955916 R 413997 CDS YP_003045945.1 254162837 8177131 complement(2957210..2958373) 1 NC_012967.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 2958373 pgk 8177131 pgk Escherichia coli B str. REL606 phosphoglycerate kinase YP_003045945.1 2957210 R 413997 CDS YP_003045946.1 254162838 8179192 complement(2958423..2959442) 1 NC_012967.1 NAD-dependent; catalyzes the formation of 4-phosphoerythronate from erythrose 4-phosphate in the biosynthesis of pyridoxine 5'-phosphate; erythrose 4-phosphate dehydrogenase 2959442 epd 8179192 epd Escherichia coli B str. REL606 erythrose 4-phosphate dehydrogenase YP_003045946.1 2958423 R 413997 CDS YP_003045947.1 254162839 8177132 complement(2959727..2960440) 1 NC_012967.1 similar to b2928; putative fructose transport system kinase 2960440 frcK 8177132 frcK Escherichia coli B str. REL606 putative fructose transport system kinase YP_003045947.1 2959727 R 413997 CDS YP_003045948.1 254162840 8177133 complement(2960437..2960946) 1 NC_012967.1 similar to b2929; putative DNA-binding transcriptional regulator 2960946 yggD 8177133 yggD Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003045948.1 2960437 R 413997 CDS YP_003045949.1 254162841 8177134 complement(2960968..2961933) 1 NC_012967.1 similar to b2930; fructose-1,6-bisphosphatase II-like protein 2961933 yggF 8177134 yggF Escherichia coli B str. REL606 fructose-1,6-bisphosphatase II-like protein YP_003045949.1 2960968 R 413997 CDS YP_003045950.1 254162842 8177135 complement(2961930..2963207) 1 NC_012967.1 similar to b4465; putative dehydrogenase 2963207 yggP 8177135 yggP Escherichia coli B str. REL606 putative dehydrogenase YP_003045950.1 2961930 R 413997 CDS YP_003045951.1 254162843 8177136 complement(2963222..2964610) 1 NC_012967.1 similar to b2933; putative fused mannitol-specific PTS enzymes: IIB component/IIC component 2964610 cmtA 8177136 cmtA Escherichia coli B str. REL606 putative fused mannitol-specific PTS enzymes: IIB component/IIC component YP_003045951.1 2963222 R 413997 CDS YP_003045952.1 254162844 8177137 complement(2964665..2965081) 1 NC_012967.1 TolM; with CmtA (IIBC), CmtB possibly forms the mannitol-like permease component of the cryptic mannitol phosphotransferase system, which phosphorylates and transports various carbohydrates and polyhydric alcohols in Escherichia coli; cytoplasmic protein; putative mannitol phosphotransferase subunit EIIA 2965081 cmtB 8177137 cmtB Escherichia coli B str. REL606 putative mannitol phosphotransferase subunit EIIA YP_003045952.1 2964665 R 413997 CDS YP_003045953.1 254162845 8178657 complement(2965395..2967386) 1 NC_012967.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 2967386 tktA 8178657 tktA Escherichia coli B str. REL606 transketolase YP_003045953.1 2965395 R 413997 CDS YP_003045954.1 254162846 8177138 2967664..2968422 1 NC_012967.1 similar to b2936; putative peptidase 2968422 yggG 8177138 yggG Escherichia coli B str. REL606 putative peptidase YP_003045954.1 2967664 D 413997 CDS YP_003045955.1 254162847 8177139 complement(2968628..2969548) 1 NC_012967.1 catalyzes the formation of putrescine from agmatine; agmatinase 2969548 speB 8177139 speB Escherichia coli B str. REL606 agmatinase YP_003045955.1 2968628 R 413997 CDS YP_003045956.1 254162848 8178658 complement(2969686..2971662) 1 NC_012967.1 catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis; arginine decarboxylase 2971662 speA 8178658 speA Escherichia coli B str. REL606 arginine decarboxylase YP_003045956.1 2969686 R 413997 CDS YP_003045957.1 254162849 8177140 complement(2971671..2971817) 1 NC_012967.1 similar to b2939; hypothetical protein 2971817 yqgB 8177140 yqgB Escherichia coli B str. REL606 hypothetical protein YP_003045957.1 2971671 R 413997 CDS YP_003045958.1 254162850 8179193 2971938..2972153 1 NC_012967.1 similar to b2940; hypothetical protein 2972153 yqgC 8179193 yqgC Escherichia coli B str. REL606 hypothetical protein YP_003045958.1 2971938 D 413997 CDS YP_003045959.1 254162851 8177141 complement(2972150..2972401) 1 NC_012967.1 similar to b2941; putative inner membrane protein 2972401 yqgD 8177141 yqgD Escherichia coli B str. REL606 putative inner membrane protein YP_003045959.1 2972150 R 413997 CDS YP_003045960.1 254162852 8177142 2972457..2973611 1 NC_012967.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 2973611 metK 8177142 metK Escherichia coli B str. REL606 S-adenosylmethionine synthetase YP_003045960.1 2972457 D 413997 CDS YP_003045961.1 254162853 8179194 2974035..2975429 1 NC_012967.1 similar to b2943; D-galactose transporter 2975429 galP 8179194 galP Escherichia coli B str. REL606 D-galactose transporter YP_003045961.1 2974035 D 413997 CDS YP_003045962.1 254162854 8177143 2975506..2976003 1 NC_012967.1 similar to b2944; hypothetical protein 2976003 sprT 8177143 sprT Escherichia coli B str. REL606 hypothetical protein YP_003045962.1 2975506 D 413997 CDS YP_003045963.1 254162855 8177144 2976098..2976805 1 NC_012967.1 similar to b2945; DNA-specific endonuclease I 2976805 endA 8177144 endA Escherichia coli B str. REL606 DNA-specific endonuclease I YP_003045963.1 2976098 D 413997 CDS YP_003045964.1 254162856 8177145 2976885..2977616 1 NC_012967.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 2977616 yggJ 8177145 yggJ Escherichia coli B str. REL606 16S ribosomal RNA methyltransferase RsmE YP_003045964.1 2976885 D 413997 CDS YP_003045965.1 254162857 8178659 2977629..2978579 1 NC_012967.1 catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione; glutathione synthetase 2978579 gshB 8178659 gshB Escherichia coli B str. REL606 glutathione synthetase YP_003045965.1 2977629 D 413997 CDS YP_003045966.1 254162858 8177146 2978688..2979251 1 NC_012967.1 similar to b2948; hypothetical protein 2979251 yqgE 8177146 yqgE Escherichia coli B str. REL606 hypothetical protein YP_003045966.1 2978688 D 413997 CDS YP_003045967.1 254162859 8177147 2979251..2979667 1 NC_012967.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 2979667 yqgF 8177147 yqgF Escherichia coli B str. REL606 Holliday junction resolvase-like protein YP_003045967.1 2979251 D 413997 CDS YP_003045968.1 254162860 8178660 complement(2979851..2980831) 1 NC_012967.1 similar to b2950; putative transporter 2980831 yggR 8178660 yggR Escherichia coli B str. REL606 putative transporter YP_003045968.1 2979851 R 413997 CDS YP_003045969.1 254162861 8177148 2980849..2981553 1 NC_012967.1 similar to b2951; hypothetical protein 2981553 yggS 8177148 yggS Escherichia coli B str. REL606 hypothetical protein YP_003045969.1 2980849 D 413997 CDS YP_003045970.1 254162862 8177149 2981571..2982137 1 NC_012967.1 similar to b2952; putative inner membrane protein 2982137 yggT 8177149 yggT Escherichia coli B str. REL606 putative inner membrane protein YP_003045970.1 2981571 D 413997 CDS YP_003045971.1 254162863 8178661 2982134..2982424 1 NC_012967.1 similar to b2953; hypothetical protein 2982424 yggU 8178661 yggU Escherichia coli B str. REL606 hypothetical protein YP_003045971.1 2982134 D 413997 CDS YP_003045972.1 254162864 8177150 2982432..2983025 1 NC_012967.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; putative deoxyribonucleotide triphosphate pyrophosphatase 2983025 yggV 8177150 yggV Escherichia coli B str. REL606 putative deoxyribonucleotide triphosphate pyrophosphatase YP_003045972.1 2982432 D 413997 CDS YP_003045973.1 254162865 8179195 2983018..2984154 1 NC_012967.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 2984154 yggW 8179195 yggW Escherichia coli B str. REL606 coproporphyrinogen III oxidase YP_003045973.1 2983018 D 413997 CDS YP_003045974.1 254162866 8177151 complement(2984219..2985226) 1 NC_012967.1 similar to b2956; hypothetical protein 2985226 yggM 8177151 yggM Escherichia coli B str. REL606 hypothetical protein YP_003045974.1 2984219 R 413997 CDS YP_003045975.1 254162867 8177152 complement(2985343..2986389) 1 NC_012967.1 catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis; L-asparaginase II 2986389 ansB 8177152 ansB Escherichia coli B str. REL606 L-asparaginase II YP_003045975.1 2985343 R 413997 CDS YP_003045976.1 254162868 8177153 complement(2986565..2987284) 1 NC_012967.1 similar to b2958; hypothetical protein 2987284 yggN 8177153 yggN Escherichia coli B str. REL606 hypothetical protein YP_003045976.1 2986565 R 413997 CDS YP_003045977.1 254162869 8177154 complement(2987468..2987794) 1 NC_012967.1 similar to b2959; hypothetical protein 2987794 yggL 8177154 yggL Escherichia coli B str. REL606 hypothetical protein YP_003045977.1 2987468 R 413997 CDS YP_003045978.1 254162870 8177155 complement(2987794..2988513) 1 NC_012967.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 2988513 trmB 8177155 trmB Escherichia coli B str. REL606 tRNA (guanine-N(7)-)-methyltransferase YP_003045978.1 2987794 R 413997 CDS YP_003045979.1 254162871 8177156 2988674..2989726 1 NC_012967.1 similar to b2961; adenine DNA glycosylase 2989726 mutY 8177156 mutY Escherichia coli B str. REL606 adenine DNA glycosylase YP_003045979.1 2988674 D 413997 CDS YP_003045980.1 254162872 8177157 2989754..2990029 1 NC_012967.1 similar to b2962; hypothetical protein 2990029 yggX 8177157 yggX Escherichia coli B str. REL606 hypothetical protein YP_003045980.1 2989754 D 413997 CDS YP_003045981.1 254162873 8177158 2990094..2991173 1 NC_012967.1 Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase C 2991173 mltC 8177158 mltC Escherichia coli B str. REL606 murein transglycosylase C YP_003045981.1 2990094 D 413997 CDS YP_003045982.1 254162874 8177159 2991375..2992631 1 NC_012967.1 similar to b2964; nucleoside transporter 2992631 nupG 8177159 nupG Escherichia coli B str. REL606 nucleoside transporter YP_003045982.1 2991375 D 413997 CDS YP_003045983.1 254162875 8179196 complement(2992680..2994815) 1 NC_012967.1 similar to b2965; ornithine decarboxylase 2994815 speC 8179196 speC Escherichia coli B str. REL606 ornithine decarboxylase YP_003045983.1 2992680 R 413997 CDS YP_003045984.1 254162876 8177160 2995208..2995915 1 NC_012967.1 similar to b2966; putative inner membrane protein 2995915 yqgA 8177160 yqgA Escherichia coli B str. REL606 putative inner membrane protein YP_003045984.1 2995208 D 413997 CDS YP_003045985.1 254162877 8179197 2996369..2997253 1 NC_012967.1 integrase 2997253 8179197 ECB_02797 Escherichia coli B str. REL606 integrase YP_003045985.1 2996369 D 413997 CDS YP_003045986.1 254162878 8177162 2997333..2998235 1 NC_012967.1 hypothetical protein 2998235 8177162 ECB_02798 Escherichia coli B str. REL606 hypothetical protein YP_003045986.1 2997333 D 413997 CDS YP_003045987.1 254162879 8177164 2999564..3002410 1 NC_012967.1 similar to b2000; antigen 43 (Ag43) phase-variable biofilm formation autotransporter 3002410 flu 8177164 flu Escherichia coli B str. REL606 antigen 43 (Ag43) phase-variable biofilm formation autotransporter YP_003045987.1 2999564 D 413997 CDS YP_003045988.1 254162880 8177165 3002531..3005047 1 NC_012967.1 similar to b2001; hypothetical protein 3005047 yeeR 8177165 yeeR Escherichia coli B str. REL606 hypothetical protein YP_003045988.1 3002531 D 413997 CDS YP_003045989.1 254162881 8177166 3005124..3005579 1 NC_012967.1 hypothetical protein 3005579 8177166 ECB_02802 Escherichia coli B str. REL606 hypothetical protein YP_003045989.1 3005124 D 413997 CDS YP_003045990.1 254162882 8177167 3005991..3006809 1 NC_012967.1 similar to b0252; hypothetical protein 3006809 yafZ 8177167 yafZ Escherichia coli B str. REL606 hypothetical protein YP_003045990.1 3005991 D 413997 CDS YP_003045991.1 254162883 8178662 complement(3006918..3007829) 1 NC_012967.1 hypothetical protein 3007829 8178662 ECB_02804 Escherichia coli B str. REL606 hypothetical protein YP_003045991.1 3006918 R 413997 CDS YP_003045992.1 254162884 8177168 3007395..3007841 1 NC_012967.1 similar to b2002; putative DNA repair protein 3007841 yeeS 8177168 yeeS Escherichia coli B str. REL606 putative DNA repair protein YP_003045992.1 3007395 D 413997 CDS YP_003045993.1 254162885 8177169 3007904..3008125 1 NC_012967.1 similar to b2003; hypothetical protein 3008125 yeeT 8177169 yeeT Escherichia coli B str. REL606 hypothetical protein YP_003045993.1 3007904 D 413997 CDS YP_003045994.1 254162886 8178663 3008144..3009205 1 NC_012967.1 similar to b2004; antitoxin of the YeeV-YeeU toxin-antitoxin system 3009205 yeeU 8178663 yeeU Escherichia coli B str. REL606 antitoxin of the YeeV-YeeU toxin-antitoxin system YP_003045994.1 3008144 D 413997 CDS YP_003045995.1 254162887 8177170 3009295..3009669 1 NC_012967.1 similar to b2005; toxin of the YeeV-YeeU toxin-antitoxin system 3009669 yeeV 8177170 yeeV Escherichia coli B str. REL606 toxin of the YeeV-YeeU toxin-antitoxin system YP_003045995.1 3009295 D 413997 CDS YP_003045996.1 254162888 8179198 3009666..3010154 1 NC_012967.1 similar to b2006; hypothetical protein 3010154 yeeW 8179198 yeeW Escherichia coli B str. REL606 hypothetical protein YP_003045996.1 3009666 D 413997 CDS YP_003045997.1 254162889 8177171 3010166..3010363 1 NC_012967.1 hypothetical protein 3010363 8177171 ECB_02810 Escherichia coli B str. REL606 hypothetical protein YP_003045997.1 3010166 D 413997 CDS YP_003045998.1 254162890 8177172 3010460..3011029 1 NC_012967.1 hypothetical protein 3011029 8177172 ECB_02811 Escherichia coli B str. REL606 hypothetical protein YP_003045998.1 3010460 D 413997 CDS YP_003045999.1 254162891 8179199 complement(3011267..3011560) 1 NC_012967.1 hypothetical protein 3011560 8179199 ECB_02812 Escherichia coli B str. REL606 hypothetical protein YP_003045999.1 3011267 R 413997 CDS YP_003046000.1 254162892 8177173 3012134..3012289 1 NC_012967.1 hypothetical protein 3012289 8177173 ECB_02813 Escherichia coli B str. REL606 hypothetical protein YP_003046000.1 3012134 D 413997 CDS YP_003046001.1 254162893 8177174 3012317..3013336 1 NC_012967.1 hypothetical protein 3013336 8177174 ECB_02814 Escherichia coli B str. REL606 hypothetical protein YP_003046001.1 3012317 D 413997 CDS YP_003046002.1 254162894 8177175 3013420..3014556 1 NC_012967.1 Capsule polysaccharide export inner-membrane protein kpsE 3014556 8177175 ECB_02815 Escherichia coli B str. REL606 Capsule polysaccharide export inner-membrane protein kpsE YP_003046002.1 3013420 D 413997 CDS YP_003046003.1 254162895 8178664 3014580..3016256 1 NC_012967.1 KpsD protein 3016256 8178664 ECB_02816 Escherichia coli B str. REL606 KpsD protein YP_003046003.1 3014580 D 413997 CDS YP_003046004.1 254162896 8177176 3016266..3017006 1 NC_012967.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 3017006 8177176 ECB_02817 Escherichia coli B str. REL606 3-deoxy-manno-octulosonate cytidylyltransferase YP_003046004.1 3016266 D 413997 CDS YP_003046005.1 254162897 8177177 3017003..3019030 1 NC_012967.1 Capsule polysaccharide export protein KpsC 3019030 8177177 ECB_02818 Escherichia coli B str. REL606 Capsule polysaccharide export protein KpsC YP_003046005.1 3017003 D 413997 CDS YP_003046006.1 254162898 8178665 3019065..3020297 1 NC_012967.1 KpsS protein 3020297 8178665 ECB_02819 Escherichia coli B str. REL606 KpsS protein YP_003046006.1 3019065 D 413997 CDS YP_003046007.1 254162899 8177178 complement(3020551..3021483) 1 NC_012967.1 hypothetical protein 3021483 8177178 ECB_02820 Escherichia coli B str. REL606 hypothetical protein YP_003046007.1 3020551 R 413997 CDS YP_003046008.1 254162900 8177179 complement(3021545..3022684) 1 NC_012967.1 hypothetical protein 3022684 8177179 ECB_02821 Escherichia coli B str. REL606 hypothetical protein YP_003046008.1 3021545 R 413997 CDS YP_003046009.1 254162901 8179200 complement(3023258..3023722) 1 NC_012967.1 bifunctional Ribulose 5-phosphate reductase/CDP-ribitol pyrophosphorylase 3023722 8179200 ECB_02822 Escherichia coli B str. REL606 bifunctional Ribulose 5-phosphate reductase/CDP-ribitol pyrophosphorylase YP_003046009.1 3023258 R 413997 CDS YP_003046010.1 254162902 8177180 complement(3023960..3024463) 1 NC_012967.1 IS1 protein InsB 3024463 insB-22 8177180 insB-22 Escherichia coli B str. REL606 IS1 protein InsB YP_003046010.1 3023960 R 413997 CDS YP_003046011.1 254162903 8177181 complement(3024382..3024657) 1 NC_012967.1 IS1 protein InsA 3024657 insA-22 8177181 insA-22 Escherichia coli B str. REL606 IS1 protein InsA YP_003046011.1 3024382 R 413997 CDS YP_003046012.1 254162904 8177182 complement(3024686..3025408) 1 NC_012967.1 Pyrophosphorylase 3025408 8177182 ECB_02825 Escherichia coli B str. REL606 Pyrophosphorylase YP_003046012.1 3024686 R 413997 CDS YP_003046013.1 254162905 8177183 complement(3025426..3026802) 1 NC_012967.1 hypothetical protein 3026802 8177183 ECB_02826 Escherichia coli B str. REL606 hypothetical protein YP_003046013.1 3025426 R 413997 CDS YP_003046014.1 254162906 8177184 complement(3027011..3027670) 1 NC_012967.1 Polysialic acid transport ATP-binding KpsT 3027670 8177184 ECB_02827 Escherichia coli B str. REL606 Polysialic acid transport ATP-binding KpsT YP_003046014.1 3027011 R 413997 CDS YP_003046015.1 254162907 8177185 complement(3027685..3028461) 1 NC_012967.1 Polysialic acid transport protein kpsM 3028461 8177185 ECB_02828 Escherichia coli B str. REL606 Polysialic acid transport protein kpsM YP_003046015.1 3027685 R 413997 CDS YP_003046016.1 254162908 8177186 complement(3029522..3030058) 1 NC_012967.1 similar to b2968; putative general secretion pathway protein YghD 3030058 yghD 8177186 yghD Escherichia coli B str. REL606 putative general secretion pathway protein YghD YP_003046016.1 3029522 R 413997 CDS YP_003046017.1 254162909 8177188 complement(3031235..3032170) 1 NC_012967.1 type II secretion protein GspK 3032170 8177188 ECB_02831 Escherichia coli B str. REL606 type II secretion protein GspK YP_003046017.1 3031235 R 413997 CDS YP_003046018.1 254162910 8177189 complement(3032209..3032772) 1 NC_012967.1 type II secretion protein GspJ 3032772 8177189 ECB_02832 Escherichia coli B str. REL606 type II secretion protein GspJ YP_003046018.1 3032209 R 413997 CDS YP_003046019.1 254162911 8177190 complement(3032811..3033182) 1 NC_012967.1 type II secretion protein 3033182 8177190 ECB_02833 Escherichia coli B str. REL606 type II secretion protein YP_003046019.1 3032811 R 413997 CDS YP_003046020.1 254162912 8177191 complement(3033179..3033742) 1 NC_012967.1 type II secretion protein GspH 3033742 8177191 ECB_02834 Escherichia coli B str. REL606 type II secretion protein GspH YP_003046020.1 3033179 R 413997 CDS YP_003046021.1 254162913 8177192 complement(3033746..3034201) 1 NC_012967.1 type II secretion protein GspG 3034201 8177192 ECB_02835 Escherichia coli B str. REL606 type II secretion protein GspG YP_003046021.1 3033746 R 413997 CDS YP_003046022.1 254162914 8179201 complement(3034218..3035441) 1 NC_012967.1 type II secretion protein GspF 3035441 8179201 ECB_02836 Escherichia coli B str. REL606 type II secretion protein GspF YP_003046022.1 3034218 R 413997 CDS YP_003046023.1 254162915 8177193 complement(3035441..3036934) 1 NC_012967.1 type II secretion protein GspE 3036934 8177193 ECB_02837 Escherichia coli B str. REL606 type II secretion protein GspE YP_003046023.1 3035441 R 413997 CDS YP_003046024.1 254162916 8177194 complement(3036934..3038994) 1 NC_012967.1 type II secretion protein GspD 3038994 8177194 ECB_02838 Escherichia coli B str. REL606 type II secretion protein GspD YP_003046024.1 3036934 R 413997 CDS YP_003046025.1 254162917 8177195 complement(3039024..3039854) 1 NC_012967.1 part of the general (type II) secretion pathway (GSP), a signal sequence-dependent process responsible for protein export; involved in trans-location of exoproteins from the cytoplasm to the periplasm; putative type II secretion protein GspC 3039854 yghF 8177195 yghF Escherichia coli B str. REL606 putative type II secretion protein GspC YP_003046025.1 3039024 R 413997 CDS YP_003046026.1 254162918 8177196 complement(3040001..3040411) 1 NC_012967.1 similar to b2971; hypothetical protein 3040411 yghG 8177196 yghG Escherichia coli B str. REL606 hypothetical protein YP_003046026.1 3040001 R 413997 CDS YP_003046027.1 254162919 8177197 complement(3040477..3041286) 1 NC_012967.1 similar to b2972; bifunctional prepilin leader peptidase/ methylase 3041286 pppA 8177197 pppA Escherichia coli B str. REL606 bifunctional prepilin leader peptidase/ methylase YP_003046027.1 3040477 R 413997 CDS YP_003046028.1 254162920 8177198 complement(3041450..3046003) 1 NC_012967.1 similar to b4466; putative inner membrane lipoprotein 3046003 yghJ 8177198 yghJ Escherichia coli B str. REL606 putative inner membrane lipoprotein YP_003046028.1 3041450 R 413997 CDS YP_003046029.1 254162921 8177199 complement(3046489..3048171) 1 NC_012967.1 similar to b2975; glycolate transporter 3048171 yghK 8177199 yghK Escherichia coli B str. REL606 glycolate transporter YP_003046029.1 3046489 R 413997 CDS YP_003046030.1 254162922 8178666 complement(3048526..3050697) 1 NC_012967.1 catalyzes the formation of malate from glyoxylate and acetyl-CoA; malate synthase G 3050697 glcB 8178666 glcB Escherichia coli B str. REL606 malate synthase G YP_003046030.1 3048526 R 413997 CDS YP_003046031.1 254162923 8177200 complement(3050719..3051123) 1 NC_012967.1 similar to b2977; hypothetical protein 3051123 glcG 8177200 glcG Escherichia coli B str. REL606 hypothetical protein YP_003046031.1 3050719 R 413997 CDS YP_003046032.1 254162924 8177201 complement(3051128..3052351) 1 NC_012967.1 similar to b4467; glycolate oxidase iron-sulfur subunit 3052351 glcF 8177201 glcF Escherichia coli B str. REL606 glycolate oxidase iron-sulfur subunit YP_003046032.1 3051128 R 413997 CDS YP_003046033.1 254162925 8177202 complement(3052362..3053414) 1 NC_012967.1 similar to b4468; glycolate oxidase FAD binding subunit 3053414 glcE 8177202 glcE Escherichia coli B str. REL606 glycolate oxidase FAD binding subunit YP_003046033.1 3052362 R 413997 CDS YP_003046034.1 254162926 8179202 complement(3053414..3054913) 1 NC_012967.1 similar to b2979; glycolate oxidase subunit GlcD 3054913 glcD 8179202 glcD Escherichia coli B str. REL606 glycolate oxidase subunit GlcD YP_003046034.1 3053414 R 413997 CDS YP_003046035.1 254162927 8177203 3055164..3055928 1 NC_012967.1 similar to b2980; DNA-binding transcriptional regulator GlcC 3055928 glcC 8177203 glcC Escherichia coli B str. REL606 DNA-binding transcriptional regulator GlcC YP_003046035.1 3055164 D 413997 CDS YP_003046036.1 254162928 8177204 complement(3055935..3057077) 1 NC_012967.1 similar to b2981; putative DNA-binding transcriptional regulator 3057077 yghO 8177204 yghO Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003046036.1 3055935 R 413997 CDS YP_003046037.1 254162929 8177205 3057445..3059175 1 NC_012967.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 3059175 8177205 ECB_02851 Escherichia coli B str. REL606 acyl-CoA synthetase YP_003046037.1 3057445 D 413997 CDS YP_003046038.1 254162930 8177206 3059172..3060086 1 NC_012967.1 hypothetical protein 3060086 8177206 ECB_02852 Escherichia coli B str. REL606 hypothetical protein YP_003046038.1 3059172 D 413997 CDS YP_003046039.1 254162931 8177207 3060118..3060366 1 NC_012967.1 hypothetical protein 3060366 8177207 ECB_02853 Escherichia coli B str. REL606 hypothetical protein YP_003046039.1 3060118 D 413997 CDS YP_003046040.1 254162932 8177208 3060366..3061538 1 NC_012967.1 hypothetical protein 3061538 8177208 ECB_02854 Escherichia coli B str. REL606 hypothetical protein YP_003046040.1 3060366 D 413997 CDS YP_003046041.1 254162933 8177209 complement(3061573..3062733) 1 NC_012967.1 hypothetical protein 3062733 8177209 ECB_02855 Escherichia coli B str. REL606 hypothetical protein YP_003046041.1 3061573 R 413997 CDS YP_003046042.1 254162934 8178667 complement(3062649..3063719) 1 NC_012967.1 hypothetical protein 3063719 8178667 ECB_02856 Escherichia coli B str. REL606 hypothetical protein YP_003046042.1 3062649 R 413997 CDS YP_003046043.1 254162935 8178668 complement(3063750..3064310) 1 NC_012967.1 hypothetical protein 3064310 8178668 ECB_02857 Escherichia coli B str. REL606 hypothetical protein YP_003046043.1 3063750 R 413997 CDS YP_003046044.1 254162936 8177210 complement(3064322..3065146) 1 NC_012967.1 hypothetical protein 3065146 8177210 ECB_02858 Escherichia coli B str. REL606 hypothetical protein YP_003046044.1 3064322 R 413997 CDS YP_003046045.1 254162937 8177211 complement(3065146..3066495) 1 NC_012967.1 similar to b2983; putative inner membrane protein 3066495 yghQ 8177211 yghQ Escherichia coli B str. REL606 putative inner membrane protein YP_003046045.1 3065146 R 413997 CDS YP_003046046.1 254162938 8177212 complement(3066541..3067299) 1 NC_012967.1 similar to b2984; hypothetical protein 3067299 yghR 8177212 yghR Escherichia coli B str. REL606 hypothetical protein YP_003046046.1 3066541 R 413997 CDS YP_003046047.1 254162939 8177213 complement(3067331..3068044) 1 NC_012967.1 similar to b2985; hypothetical protein 3068044 yghS 8177213 yghS Escherichia coli B str. REL606 hypothetical protein YP_003046047.1 3067331 R 413997 CDS YP_003046048.1 254162940 8177214 3068218..3068910 1 NC_012967.1 similar to b2986; hypothetical protein 3068910 yghT 8177214 yghT Escherichia coli B str. REL606 hypothetical protein YP_003046048.1 3068218 D 413997 CDS YP_003046049.1 254162941 8178669 complement(3068959..3070458) 1 NC_012967.1 similar to b2987; phosphate transporter 3070458 pitB 8178669 pitB Escherichia coli B str. REL606 phosphate transporter YP_003046049.1 3068959 R 413997 CDS YP_003046050.1 254162942 8177215 complement(3070750..3072609) 1 NC_012967.1 catalyzes the formation of glutathionylspermidine from glutathione and spermidine; also catalyzes the reverse reaction; bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase 3072609 gss 8177215 gss Escherichia coli B str. REL606 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase YP_003046050.1 3070750 R 413997 CDS YP_003046051.1 254162943 8177216 3072814..3073680 1 NC_012967.1 YghU; B2989; one of eight putative glutathione transferase proteins from E. coli; putative glutathione S-transferase YghU 3073680 yghU 8177216 yghU Escherichia coli B str. REL606 putative glutathione S-transferase YghU YP_003046051.1 3072814 D 413997 CDS YP_003046052.1 254162944 8177217 complement(3073803..3074051) 1 NC_012967.1 similar to b2990; hydrogenase 2 accessory protein HypG 3074051 hybG 8177217 hybG Escherichia coli B str. REL606 hydrogenase 2 accessory protein HypG YP_003046052.1 3073803 R 413997 CDS YP_003046053.1 254162945 8177218 complement(3074064..3074405) 1 NC_012967.1 plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein HybF 3074405 hybF 8177218 hybF Escherichia coli B str. REL606 hydrogenase nickel incorporation protein HybF YP_003046053.1 3074064 R 413997 CDS YP_003046054.1 254162946 8178670 complement(3074398..3074886) 1 NC_012967.1 similar to b2992; hydrogenase 2-specific chaperone 3074886 hybE 8178670 hybE Escherichia coli B str. REL606 hydrogenase 2-specific chaperone YP_003046054.1 3074398 R 413997 CDS YP_003046055.1 254162947 8178671 complement(3074879..3075373) 1 NC_012967.1 protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC); hydrogenase 2 maturation endopeptidase 3075373 hybD 8178671 hybD Escherichia coli B str. REL606 hydrogenase 2 maturation endopeptidase YP_003046055.1 3074879 R 413997 CDS YP_003046056.1 254162948 8177219 complement(3075373..3077076) 1 NC_012967.1 involved in hydrogen uptake; hydrogenase 2 large subunit 3077076 hybC 8177219 hybC Escherichia coli B str. REL606 hydrogenase 2 large subunit YP_003046056.1 3075373 R 413997 CDS YP_003046057.1 254162949 8177220 complement(3077073..3078251) 1 NC_012967.1 HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits; putative hydrogenase 2 b cytochrome subunit 3078251 hybB 8177220 hybB Escherichia coli B str. REL606 putative hydrogenase 2 b cytochrome subunit YP_003046057.1 3077073 R 413997 CDS YP_003046058.1 254162950 8177221 complement(3078241..3079227) 1 NC_012967.1 Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2; hydrogenase 2 protein HybA 3079227 hybA 8177221 hybA Escherichia coli B str. REL606 hydrogenase 2 protein HybA YP_003046058.1 3078241 R 413997 CDS YP_003046059.1 254162951 8179203 complement(3080619..3080906) 1 NC_012967.1 similar to b2998; hypothetical protein 3080906 yghW 8179203 yghW Escherichia coli B str. REL606 hypothetical protein YP_003046059.1 3080619 R 413997 CDS YP_003046060.1 254162952 8179204 complement(3081025..3081789) 1 NC_012967.1 similar to b2999-b3000; putative hydrolase 3081789 yghXY 8179204 yghXY Escherichia coli B str. REL606 putative hydrolase YP_003046060.1 3081025 R 413997 CDS YP_003046061.1 254162953 8177223 3082069..3083109 1 NC_012967.1 similar to b3001; aldo-keto reductase 3083109 yghZ 8177223 yghZ Escherichia coli B str. REL606 aldo-keto reductase YP_003046061.1 3082069 D 413997 CDS YP_003046062.1 254162954 8177224 complement(3083149..3083643) 1 NC_012967.1 similar to b3002; hypothetical protein 3083643 yqhA 8177224 yqhA Escherichia coli B str. REL606 hypothetical protein YP_003046062.1 3083149 R 413997 CDS YP_003046063.1 254162955 8177225 3083834..3084718 1 NC_012967.1 similar to b3003; oxidoreductase 3084718 yghA 8177225 yghA Escherichia coli B str. REL606 oxidoreductase YP_003046063.1 3083834 D 413997 CDS YP_003046064.1 254162956 8177226 complement(3084990..3085415) 1 NC_012967.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbD 3085415 exbD 8177226 exbD Escherichia coli B str. REL606 biopolymer transport protein ExbD YP_003046064.1 3084990 R 413997 CDS YP_003046065.1 254162957 8178672 complement(3085422..3086156) 1 NC_012967.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbB 3086156 exbB 8178672 exbB Escherichia coli B str. REL606 biopolymer transport protein ExbB YP_003046065.1 3085422 R 413997 CDS YP_003046066.1 254162958 8178673 3086408..3087595 1 NC_012967.1 catalyzes the formation of L-homocysteine from cystathionine; cystathionine beta-lyase 3087595 metC 8178673 metC Escherichia coli B str. REL606 cystathionine beta-lyase YP_003046066.1 3086408 D 413997 CDS YP_003046067.1 254162959 8177227 3087735..3088394 1 NC_012967.1 similar to b3009; inner membrane protein 3088394 yghB 8177227 yghB Escherichia coli B str. REL606 inner membrane protein YP_003046067.1 3087735 D 413997 CDS YP_003046068.1 254162960 8177228 complement(3088434..3089390) 1 NC_012967.1 similar to b3010; putative DNA-binding transcriptional regulator 3089390 yqhC 8177228 yqhC Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003046068.1 3088434 R 413997 CDS YP_003046069.1 254162961 8177229 3089527..3090690 1 NC_012967.1 similar to b3011; alcohol dehydrogenase, NAD(P)-dependent 3090690 yqhD 8177229 yqhD Escherichia coli B str. REL606 alcohol dehydrogenase, NAD(P)-dependent YP_003046069.1 3089527 D 413997 CDS YP_003046070.1 254162962 8177230 3090795..3091622 1 NC_012967.1 methylglyoxal reductase/#-keto ester reductase; catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; also catalyzes the reduction of methylglyoxal, ethyl-2-methylacetoacetate and ethyl-acetoacetate; 2,5-diketo-D-gluconate reductase A 3091622 dkgA 8177230 dkgA Escherichia coli B str. REL606 2,5-diketo-D-gluconate reductase A YP_003046070.1 3090795 D 413997 CDS YP_003046071.1 254162963 8179205 3091822..3092748 1 NC_012967.1 similar to b3013; hypothetical protein 3092748 yqhG 8179205 yqhG Escherichia coli B str. REL606 hypothetical protein YP_003046071.1 3091822 D 413997 CDS YP_003046072.1 254162964 8179206 3092799..3093056 1 NC_012967.1 similar to b3014; putative outer membrane lipoprotein 3093056 yqhH 8179206 yqhH Escherichia coli B str. REL606 putative outer membrane lipoprotein YP_003046072.1 3092799 D 413997 CDS YP_003046073.1 254162965 8177231 complement(3093099..3095318) 1 NC_012967.1 similar to b4469; hypothetical protein 3095318 ygiQ 8177231 ygiQ Escherichia coli B str. REL606 hypothetical protein YP_003046073.1 3093099 R 413997 CDS YP_003046074.1 254162966 8177232 complement(3095429..3096841) 1 NC_012967.1 similar to b3017; repressor protein for FtsI 3096841 sufI 8177232 sufI Escherichia coli B str. REL606 repressor protein for FtsI YP_003046074.1 3095429 R 413997 CDS YP_003046075.1 254162967 8177233 complement(3096916..3097653) 1 NC_012967.1 similar to b3018; 1-acyl-sn-glycerol-3-phosphate acyltransferase 3097653 plsC 8177233 plsC Escherichia coli B str. REL606 1-acyl-sn-glycerol-3-phosphate acyltransferase YP_003046075.1 3096916 R 413997 CDS YP_003046076.1 254162968 8177234 complement(3097887..3100145) 1 NC_012967.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 3100145 parC 8177234 parC Escherichia coli B str. REL606 DNA topoisomerase IV subunit A YP_003046076.1 3097887 R 413997 CDS YP_003046077.1 254162969 8177235 complement(3100283..3101890) 1 NC_012967.1 YgiS; uncharacterized periplasmic protein that seems to be part of a binding-protein-dependent transport system; putative binding protein 3101890 ygiS 8177235 ygiS Escherichia coli B str. REL606 putative binding protein YP_003046077.1 3100283 R 413997 CDS YP_003046078.1 254162970 8179207 complement(3102023..3102418) 1 NC_012967.1 similar to b3021; putative DNA-binding transcriptional regulator 3102418 ygiT 8179207 ygiT Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003046078.1 3102023 R 413997 CDS YP_003046079.1 254162971 8177236 complement(3102420..3102716) 1 NC_012967.1 similar to b3022; putative cyanide hydratase 3102716 ygiU 8177236 ygiU Escherichia coli B str. REL606 putative cyanide hydratase YP_003046079.1 3102420 R 413997 CDS YP_003046080.1 254162972 8177237 complement(3102921..3103403) 1 NC_012967.1 similar to b3023; putative transcriptional regulator 3103403 ygiV 8177237 ygiV Escherichia coli B str. REL606 putative transcriptional regulator YP_003046080.1 3102921 R 413997 CDS YP_003046081.1 254162973 8177238 complement(3103456..3103848) 1 NC_012967.1 similar to b3024; hypothetical protein 3103848 ygiW 8177238 ygiW Escherichia coli B str. REL606 hypothetical protein YP_003046081.1 3103456 R 413997 CDS YP_003046082.1 254162974 8177239 3104000..3104659 1 NC_012967.1 response regulator in two-component regulatory system with QseC; regulates FlhCD which is the master regulator for flagella and motility genes; DNA-binding transcriptional regulator QseB 3104659 ygiX 8177239 ygiX Escherichia coli B str. REL606 DNA-binding transcriptional regulator QseB YP_003046082.1 3104000 D 413997 CDS YP_003046083.1 254162975 8179208 3104656..3106005 1 NC_012967.1 similar to b3026; sensor protein QseC 3106005 ygiY 8179208 ygiY Escherichia coli B str. REL606 sensor protein QseC YP_003046083.1 3104656 D 413997 CDS YP_003046084.1 254162976 8179209 complement(3106051..3106383) 1 NC_012967.1 similar to b3027; inner membrane protein 3106383 ygiZ 8179209 ygiZ Escherichia coli B str. REL606 inner membrane protein YP_003046084.1 3106051 R 413997 CDS YP_003046085.1 254162977 8177240 3106702..3107283 1 NC_012967.1 similar to b3028; NADPH quinone reductase 3107283 mdaB 8177240 mdaB Escherichia coli B str. REL606 NADPH quinone reductase YP_003046085.1 3106702 D 413997 CDS YP_003046086.1 254162978 8177241 3107314..3107628 1 NC_012967.1 similar to b3029; quinol monooxygenase 3107628 ygiN 8177241 ygiN Escherichia coli B str. REL606 quinol monooxygenase YP_003046086.1 3107314 D 413997 CDS YP_003046087.1 254162979 8177242 complement(3107676..3109568) 1 NC_012967.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 3109568 parE 8177242 parE Escherichia coli B str. REL606 DNA topoisomerase IV subunit B YP_003046087.1 3107676 R 413997 CDS YP_003046088.1 254162980 8177243 complement(3109597..3110178) 1 NC_012967.1 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase YqiA 3110178 yqiA 8177243 yqiA Escherichia coli B str. REL606 esterase YqiA YP_003046088.1 3109597 R 413997 CDS YP_003046089.1 254162981 8177244 complement(3110178..3111005) 1 NC_012967.1 similar to b3032; cyclic 3',5'-adenosine monophosphate phosphodiesterase 3111005 cpdA 8177244 cpdA Escherichia coli B str. REL606 cyclic 3',5'-adenosine monophosphate phosphodiesterase YP_003046089.1 3110178 R 413997 CDS YP_003046090.1 254162982 8177245 complement(3111030..3111452) 1 NC_012967.1 similar to b3033; hypothetical protein 3111452 yqiB 8177245 yqiB Escherichia coli B str. REL606 hypothetical protein YP_003046090.1 3111030 R 413997 CDS YP_003046091.1 254162983 8177246 complement(3111453..3112082) 1 NC_012967.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose pyrophosphatase NudF 3112082 nudF 8177246 nudF Escherichia coli B str. REL606 ADP-ribose pyrophosphatase NudF YP_003046091.1 3111453 R 413997 CDS YP_003046092.1 254162984 8178674 3112287..3113768 1 NC_012967.1 trimeric outer membrane protein involved in efflux of hydrophobic/amphipathic molecules; functions with a number of efflux systems in the inner membrane to transport molecules out of the cell; outer membrane channel protein 3113768 tolC 8178674 tolC Escherichia coli B str. REL606 outer membrane channel protein YP_003046092.1 3112287 D 413997 CDS YP_003046093.1 254162985 8177247 3113768..3114028 1 NC_012967.1 similar to b3036; hypothetical protein 3114028 ygiA 8177247 ygiA Escherichia coli B str. REL606 hypothetical protein YP_003046093.1 3113768 D 413997 CDS YP_003046094.1 254162986 8177248 3114012..3114587 1 NC_012967.1 similar to b3037; hypothetical protein 3114587 ygiB 8177248 ygiB Escherichia coli B str. REL606 hypothetical protein YP_003046094.1 3114012 D 413997 CDS YP_003046095.1 254162987 8179210 3114593..3115753 1 NC_012967.1 similar to b3038; hypothetical protein 3115753 ygiC 8179210 ygiC Escherichia coli B str. REL606 hypothetical protein YP_003046095.1 3114593 D 413997 CDS YP_003046096.1 254162988 8179211 complement(3115791..3116606) 1 NC_012967.1 seems to be involved in biofilm formation; in asymptomatic bacteriuria E. coli strains 83972 and VR50, the ygiD gene is upregulated during biofilm formation in urine; hypothetical protein 3116606 ygiD 8179211 ygiD Escherichia coli B str. REL606 hypothetical protein YP_003046096.1 3115791 R 413997 CDS YP_003046097.1 254162989 8177249 3116722..3117495 1 NC_012967.1 similar to b3040; zinc transporter ZupT 3117495 ygiE 8177249 ygiE Escherichia coli B str. REL606 zinc transporter ZupT YP_003046097.1 3116722 D 413997 CDS YP_003046098.1 254162990 8178675 complement(3117985..3118638) 1 NC_012967.1 DHBP synthase; functions during riboflavin biosynthesis; 3,4-dihydroxy-2-butanone 4-phosphate synthase 3118638 ribB 8178675 ribB Escherichia coli B str. REL606 3,4-dihydroxy-2-butanone 4-phosphate synthase YP_003046098.1 3117985 R 413997 CDS YP_003046099.1 254162991 8178676 3119012..3119302 1 NC_012967.1 similar to b3042; hypothetical protein 3119302 yqiC 8178676 yqiC Escherichia coli B str. REL606 hypothetical protein YP_003046099.1 3119012 D 413997 CDS YP_003046100.1 254162992 8177250 3119586..3120137 1 NC_012967.1 similar to b3043; putative fimbrial protein 3120137 ygiL 8177250 ygiL Escherichia coli B str. REL606 putative fimbrial protein YP_003046100.1 3119586 D 413997 CDS YP_003046101.1 254162993 8177251 3120233..3122701 1 NC_012967.1 similar to b3046; putative outer membrane usher protein 3122701 yqiG 8177251 yqiG Escherichia coli B str. REL606 putative outer membrane usher protein YP_003046101.1 3120233 D 413997 CDS YP_003046102.1 254162994 8179212 3122717..3123466 1 NC_012967.1 similar to b3047; putative periplasmic pilin chaperone 3123466 yqiH 8179212 yqiH Escherichia coli B str. REL606 putative periplasmic pilin chaperone YP_003046102.1 3122717 D 413997 CDS YP_003046103.1 254162995 8177252 3123468..3124532 1 NC_012967.1 similar to b3048; hypothetical protein 3124532 yqiI 8177252 yqiI Escherichia coli B str. REL606 hypothetical protein YP_003046103.1 3123468 D 413997 CDS YP_003046104.1 254162996 8177253 complement(3124575..3124775) 1 NC_012967.1 Involved in glycogen synthesis. May be involved in glycogen priming; glycogen synthesis protein GlgS 3124775 glgS 8177253 glgS Escherichia coli B str. REL606 glycogen synthesis protein GlgS YP_003046104.1 3124575 R 413997 CDS YP_003046105.1 254162997 8177254 3125044..3125673 1 NC_012967.1 similar to b3050; putative inner membrane protein 3125673 yqiJ 8177254 yqiJ Escherichia coli B str. REL606 putative inner membrane protein YP_003046105.1 3125044 D 413997 CDS YP_003046106.1 254162998 8177255 3125700..3127361 1 NC_012967.1 similar to b3051; hypothetical protein 3127361 yqiK 8177255 yqiK Escherichia coli B str. REL606 hypothetical protein YP_003046106.1 3125700 D 413997 CDS YP_003046107.1 254162999 8177256 complement(3128154..3129587) 1 NC_012967.1 catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose; bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase 3129587 rfaE 8177256 rfaE Escherichia coli B str. REL606 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase YP_003046107.1 3128154 R 413997 CDS YP_003046108.1 254163000 8177257 complement(3129635..3132475) 1 NC_012967.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase 3132475 glnE 8177257 glnE Escherichia coli B str. REL606 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase YP_003046108.1 3129635 R 413997 CDS YP_003046109.1 254163001 8179213 complement(3132498..3133799) 1 NC_012967.1 similar to b3054; putative adenylate cyclase 3133799 ygiF 8179213 ygiF Escherichia coli B str. REL606 putative adenylate cyclase YP_003046109.1 3132498 R 413997 CDS YP_003046110.1 254163002 8177258 3134041..3134661 1 NC_012967.1 similar to b3055; putative signal transduction protein 3134661 ygiM 8177258 ygiM Escherichia coli B str. REL606 putative signal transduction protein YP_003046110.1 3134041 D 413997 CDS YP_003046111.1 254163003 8178677 3134725..3135963 1 NC_012967.1 catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases; multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase 3135963 cca 8178677 cca Escherichia coli B str. REL606 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase YP_003046111.1 3134725 D 413997 CDS YP_003046112.1 254163004 8179214 complement(3136126..3136947) 1 NC_012967.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; undecaprenyl pyrophosphate phosphatase 3136947 uppP 8179214 uppP Escherichia coli B str. REL606 undecaprenyl pyrophosphate phosphatase YP_003046112.1 3136126 R 413997 CDS YP_003046113.1 254163005 8177259 complement(3137038..3137406) 1 NC_012967.1 catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin; bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase 3137406 folB 8177259 folB Escherichia coli B str. REL606 bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase YP_003046113.1 3137038 R 413997 CDS YP_003046114.1 254163006 8178678 3137511..3138128 1 NC_012967.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; putative glycerol-3-phosphate acyltransferase PlsY 3138128 ygiH 8178678 ygiH Escherichia coli B str. REL606 putative glycerol-3-phosphate acyltransferase PlsY YP_003046114.1 3137511 D 413997 CDS YP_003046115.1 254163007 8177260 complement(3138141..3139073) 1 NC_012967.1 activates expression of genes required for L-tartrate-dependent anaerobic growth on glycerol; transcriptional activator TtdR 3139073 ygiP 8177260 ygiP Escherichia coli B str. REL606 transcriptional activator TtdR YP_003046115.1 3138141 R 413997 CDS YP_003046116.1 254163008 8177261 3139280..3140191 1 NC_012967.1 Involved in the tartrate degradation pathway; tartrate dehydratase subunit alpha 3140191 ttdA 8177261 ttdA Escherichia coli B str. REL606 tartrate dehydratase subunit alpha YP_003046116.1 3139280 D 413997 CDS YP_003046117.1 254163009 8177262 3140188..3140793 1 NC_012967.1 Involved in the tartrate degradation pathway; L(+)-tartrate dehydratase subunit beta 3140793 ttdB 8177262 ttdB Escherichia coli B str. REL606 L(+)-tartrate dehydratase subunit beta YP_003046117.1 3140188 D 413997 CDS YP_003046118.1 254163010 8177263 3140841..3142304 1 NC_012967.1 similar to b3063; putative tartrate:succinate antiporter 3142304 ygjE 8177263 ygjE Escherichia coli B str. REL606 putative tartrate:succinate antiporter YP_003046118.1 3140841 D 413997 CDS YP_003046119.1 254163011 8177264 complement(3142347..3143360) 1 NC_012967.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; putative DNA-binding/iron metalloprotein/AP endonuclease 3143360 ygjD 8177264 ygjD Escherichia coli B str. REL606 putative DNA-binding/iron metalloprotein/AP endonuclease YP_003046119.1 3142347 R 413997 CDS YP_003046120.1 254163012 8177265 3143598..3143813 1 NC_012967.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 3143813 rpsU 8177265 rpsU Escherichia coli B str. REL606 30S ribosomal protein S21 YP_003046120.1 3143598 D 413997 CDS YP_003046121.1 254163013 8178679 3143924..3145669 1 NC_012967.1 synthesizes RNA primers at the replication forks; DNA primase 3145669 dnaG 8178679 dnaG Escherichia coli B str. REL606 DNA primase YP_003046121.1 3143924 D 413997 CDS YP_003046122.1 254163014 8177266 3145864..3147705 1 NC_012967.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria; RNA polymerase sigma factor RpoD 3147705 rpoD 8177266 rpoD Escherichia coli B str. REL606 RNA polymerase sigma factor RpoD YP_003046122.1 3145864 D 413997 CDS YP_003046123.1 254163015 8177267 complement(3147784..3148290) 1 NC_012967.1 similar to b3068; G/U mismatch-specific DNA glycosylase 3148290 ygjF 8177267 ygjF Escherichia coli B str. REL606 G/U mismatch-specific DNA glycosylase YP_003046123.1 3147784 R 413997 CDS YP_003046124.1 254163016 8177269 complement(3148544..3149308) 1 NC_012967.1 similar to b3070; putative siderophore interacting protein 3149308 yqjH 8177269 yqjH Escherichia coli B str. REL606 putative siderophore interacting protein YP_003046124.1 3148544 R 413997 CDS YP_003046125.1 254163017 8177270 3149596..3150219 1 NC_012967.1 similar to b3071; putative transcriptional regulator 3150219 yqjI 8177270 yqjI Escherichia coli B str. REL606 putative transcriptional regulator YP_003046125.1 3149596 D 413997 CDS YP_003046126.1 254163018 8177271 complement(3150373..3151893) 1 NC_012967.1 similar to b3072; bifunctional aerotaxis signal transducer/methyl-accepting chemotaxis protein 3151893 aer 8177271 aer Escherichia coli B str. REL606 bifunctional aerotaxis signal transducer/methyl-accepting chemotaxis protein YP_003046126.1 3150373 R 413997 CDS YP_003046127.1 254163019 8177272 3152284..3153690 1 NC_012967.1 catalyzes the formation of 4-aminobutyraldehyde from putrescine and 2-oxoglutarate; putrescine--2-oxoglutarate aminotransferase 3153690 ygjG 8177272 ygjG Escherichia coli B str. REL606 putrescine--2-oxoglutarate aminotransferase YP_003046127.1 3152284 D 413997 CDS YP_003046128.1 254163020 8179215 complement(3153732..3154064) 1 NC_012967.1 similar to b3074; hypothetical protein 3154064 ygjH 8179215 ygjH Escherichia coli B str. REL606 hypothetical protein YP_003046128.1 3153732 R 413997 CDS YP_003046129.1 254163021 8177273 3154283..3155266 1 NC_012967.1 similar to b3075; DNA-binding transcriptional repressor EbgR 3155266 ebgR 8177273 ebgR Escherichia coli B str. REL606 DNA-binding transcriptional repressor EbgR YP_003046129.1 3154283 D 413997 CDS YP_003046130.1 254163022 8178680 3155450..3158542 1 NC_012967.1 in Escherichia coli this is the second beta-galactosidase system; cryptic beta-D-galactosidase subunit alpha 3158542 ebgA 8178680 ebgA Escherichia coli B str. REL606 cryptic beta-D-galactosidase subunit alpha YP_003046130.1 3155450 D 413997 CDS YP_003046131.1 254163023 8179216 3158539..3158988 1 NC_012967.1 in Escherichia coli this is the second beta-galactosidase system; cryptic beta-D-galactosidase subunit beta 3158988 ebgC 8179216 ebgC Escherichia coli B str. REL606 cryptic beta-D-galactosidase subunit beta YP_003046131.1 3158539 D 413997 CDS YP_003046132.1 254163024 8177274 3159051..3160484 1 NC_012967.1 similar to b3078; putative transporter 3160484 ygjI 8177274 ygjI Escherichia coli B str. REL606 putative transporter YP_003046132.1 3159051 D 413997 CDS YP_003046133.1 254163025 8178681 3160618..3161688 1 NC_012967.1 similar to b3079; hypothetical protein 3161688 ygjJ 8178681 ygjJ Escherichia coli B str. REL606 hypothetical protein YP_003046133.1 3160618 D 413997 CDS YP_003046134.1 254163026 8177275 3161705..3164056 1 NC_012967.1 similar to b3080; putative glycosyl hydrolase 3164056 ygjK 8177275 ygjK Escherichia coli B str. REL606 putative glycosyl hydrolase YP_003046134.1 3161705 D 413997 CDS YP_003046135.1 254163027 8177276 3164482..3166500 1 NC_012967.1 similar to b3081; 2,4-dienoyl-CoA reductase 3166500 fadH 8177276 fadH Escherichia coli B str. REL606 2,4-dienoyl-CoA reductase YP_003046135.1 3164482 D 413997 CDS YP_003046136.1 254163028 8177277 complement(3166545..3166961) 1 NC_012967.1 similar to b3082; putative DNA-binding transcriptional regulator 3166961 ygjM 8177277 ygjM Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003046136.1 3166545 R 413997 CDS YP_003046137.1 254163029 8177278 complement(3166958..3167272) 1 NC_012967.1 similar to b3083; hypothetical protein 3167272 ygjN 8177278 ygjN Escherichia coli B str. REL606 hypothetical protein YP_003046137.1 3166958 R 413997 CDS YP_003046138.1 254163030 8177279 complement(3167556..3168692) 1 NC_012967.1 similar to b3084; putative methyltransferase small domain protein 3168692 ygjO 8177279 ygjO Escherichia coli B str. REL606 putative methyltransferase small domain protein YP_003046138.1 3167556 R 413997 CDS YP_003046139.1 254163031 8177280 3168777..3169280 1 NC_012967.1 similar to b3085; putative metal dependent hydrolase 3169280 ygjP 8177280 ygjP Escherichia coli B str. REL606 putative metal dependent hydrolase YP_003046139.1 3168777 D 413997 CDS YP_003046140.1 254163032 8178682 3169357..3170049 1 NC_012967.1 similar to b3086; putative thioredoxin-like protein 3170049 ygjQ 8178682 ygjQ Escherichia coli B str. REL606 putative thioredoxin-like protein YP_003046140.1 3169357 D 413997 CDS YP_003046141.1 254163033 8177281 3170110..3171114 1 NC_012967.1 similar to b3087; putative NAD(P)-binding dehydrogenase 3171114 ygjR 8177281 ygjR Escherichia coli B str. REL606 putative NAD(P)-binding dehydrogenase YP_003046141.1 3170110 D 413997 CDS YP_003046142.1 254163034 8177282 3171397..3172362 1 NC_012967.1 similar to b3088; putative inner membrane protein, part of terminus 3172362 ygjT 8177282 ygjT Escherichia coli B str. REL606 putative inner membrane protein, part of terminus YP_003046142.1 3171397 D 413997 CDS YP_003046143.1 254163035 8177283 3172978..3174222 1 NC_012967.1 involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 3174222 ygjU 8177283 ygjU Escherichia coli B str. REL606 serine/threonine transporter SstT YP_003046143.1 3172978 D 413997 CDS YP_003046144.1 254163036 8177284 complement(3174227..3174778) 1 NC_012967.1 similar to b3090; inner membrane protein 3174778 ygjV 8177284 ygjV Escherichia coli B str. REL606 inner membrane protein YP_003046144.1 3174227 R 413997 CDS YP_003046145.1 254163037 8177285 complement(3174861..3176348) 1 NC_012967.1 similar to b3091; altronate hydrolase 3176348 uxaA 8177285 uxaA Escherichia coli B str. REL606 altronate hydrolase YP_003046145.1 3174861 R 413997 CDS YP_003046146.1 254163038 8177286 complement(3176363..3177775) 1 NC_012967.1 catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism; glucuronate isomerase 3177775 uxaC 8177286 uxaC Escherichia coli B str. REL606 glucuronate isomerase YP_003046146.1 3176363 R 413997 CDS YP_003046147.1 254163039 8177287 3178138..3179556 1 NC_012967.1 similar to b3093; hexuronate transporter 3179556 exuT 8177287 exuT Escherichia coli B str. REL606 hexuronate transporter YP_003046147.1 3178138 D 413997 CDS YP_003046148.1 254163040 8179217 3179686..3180462 1 NC_012967.1 regulates the exuT, uxaCA and uxuRAB operons which encode genes involved in hexuronate utilization.; DNA-binding transcriptional repressor ExuR 3180462 exuR 8179217 exuR Escherichia coli B str. REL606 DNA-binding transcriptional repressor ExuR YP_003046148.1 3179686 D 413997 CDS YP_003046149.1 254163041 8177288 3180807..3181469 1 NC_012967.1 similar to b3095; inner membrane protein 3181469 yqjA 8177288 yqjA Escherichia coli B str. REL606 inner membrane protein YP_003046149.1 3180807 D 413997 CDS YP_003046150.1 254163042 8178683 3181473..3181856 1 NC_012967.1 similar to b3096; hypothetical protein 3181856 yqjB 8178683 yqjB Escherichia coli B str. REL606 hypothetical protein YP_003046150.1 3181473 D 413997 CDS YP_003046151.1 254163043 8179218 3182003..3182371 1 NC_012967.1 similar to b3097; hypothetical protein 3182371 yqjC 8179218 yqjC Escherichia coli B str. REL606 hypothetical protein YP_003046151.1 3182003 D 413997 CDS YP_003046152.1 254163044 8177289 3182409..3182714 1 NC_012967.1 similar to b3098; hypothetical protein 3182714 yqjD 8177289 yqjD Escherichia coli B str. REL606 hypothetical protein YP_003046152.1 3182409 D 413997 CDS YP_003046153.1 254163045 8178684 3182717..3183121 1 NC_012967.1 similar to b3099; inner membrane protein 3183121 yqjE 8178684 yqjE Escherichia coli B str. REL606 inner membrane protein YP_003046153.1 3182717 D 413997 CDS YP_003046154.1 254163046 8177290 3183111..3183410 1 NC_012967.1 similar to b3100; hypothetical protein 3183410 yqjK 8177290 yqjK Escherichia coli B str. REL606 hypothetical protein YP_003046154.1 3183111 D 413997 CDS YP_003046155.1 254163047 8177291 3183596..3183988 1 NC_012967.1 similar to b3101; putative quinol oxidase subunit 3183988 yqjF 8177291 yqjF Escherichia coli B str. REL606 putative quinol oxidase subunit YP_003046155.1 3183596 D 413997 CDS YP_003046156.1 254163048 8177292 3184058..3185044 1 NC_012967.1 similar to b3102; putative S-transferase 3185044 yqjG 8177292 yqjG Escherichia coli B str. REL606 putative S-transferase YP_003046156.1 3184058 D 413997 CDS YP_003046157.1 254163049 8177293 3185337..3185702 1 NC_012967.1 similar to b3103; putative inner membrane protein 3185702 yhaH 8177293 yhaH Escherichia coli B str. REL606 putative inner membrane protein YP_003046157.1 3185337 D 413997 CDS YP_003046158.1 254163050 8177294 3185944..3186300 1 NC_012967.1 similar to b3104; putative inner membrane protein 3186300 yhaI 8177294 yhaI Escherichia coli B str. REL606 putative inner membrane protein YP_003046158.1 3185944 D 413997 CDS YP_003046159.1 254163051 8177295 complement(3186351..3187247) 1 NC_012967.1 similar to b3105; putative DNA-binding transcriptional regulator 3187247 yhaJ 8177295 yhaJ Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003046159.1 3186351 R 413997 CDS YP_003046160.1 254163052 8178685 3187352..3188053 1 NC_012967.1 similar to b3106; putative pirin-related protein 3188053 yhaK 8178685 yhaK Escherichia coli B str. REL606 putative pirin-related protein YP_003046160.1 3187352 D 413997 CDS YP_003046161.1 254163053 8177296 3188076..3188240 1 NC_012967.1 similar to b3107; hypothetical protein 3188240 yhaL 8177296 yhaL Escherichia coli B str. REL606 hypothetical protein YP_003046161.1 3188076 D 413997 CDS YP_003046162.1 254163054 8177297 complement(3188374..3189684) 1 NC_012967.1 similar to b4470; hypothetical protein 3189684 yhaM 8177297 yhaM Escherichia coli B str. REL606 hypothetical protein YP_003046162.1 3188374 R 413997 CDS YP_003046163.1 254163055 8177298 complement(3189712..3190980) 1 NC_012967.1 similar to b3110; putative transporter 3190980 yhaO 8177298 yhaO Escherichia coli B str. REL606 putative transporter YP_003046163.1 3189712 R 413997 CDS YP_003046164.1 254163056 8177299 complement(3191319..3192683) 1 NC_012967.1 similar to b4471; L-serine dehydratase 3 3192683 tdcG 8177299 tdcG Escherichia coli B str. REL606 L-serine dehydratase 3 YP_003046164.1 3191319 R 413997 CDS YP_003046165.1 254163057 8177300 complement(3192755..3193144) 1 NC_012967.1 similar to b3113; hypothetical protein 3193144 tdcF 8177300 tdcF Escherichia coli B str. REL606 hypothetical protein YP_003046165.1 3192755 R 413997 CDS YP_003046166.1 254163058 8177301 complement(3193158..3195452) 1 NC_012967.1 similar to b3114; pyruvate formate-lyase 4/2-ketobutyrate formate-lyase 3195452 tdcE 8177301 tdcE Escherichia coli B str. REL606 pyruvate formate-lyase 4/2-ketobutyrate formate-lyase YP_003046166.1 3193158 R 413997 CDS YP_003046167.1 254163059 8178686 complement(3195486..3196706) 1 NC_012967.1 catalyzes the formation of propanoyl phosphate from propanoate and ATP; TdcD also has acetate kinase activities and functions in anaerobic threonine catabolism; propionate/acetate kinase 3196706 tdcD 8178686 tdcD Escherichia coli B str. REL606 propionate/acetate kinase YP_003046167.1 3195486 R 413997 CDS YP_003046168.1 254163060 8177302 complement(3196720..3198051) 1 NC_012967.1 involved in the import of threonine and serine in combination with the import of a proton; threonine/serine transporter TdcC 3198051 tdcC 8177302 tdcC Escherichia coli B str. REL606 threonine/serine transporter TdcC YP_003046168.1 3196720 R 413997 CDS YP_003046169.1 254163061 8177303 complement(3198073..3199062) 1 NC_012967.1 catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic; threonine dehydratase 3199062 tdcB 8177303 tdcB Escherichia coli B str. REL606 threonine dehydratase YP_003046169.1 3198073 R 413997 CDS YP_003046170.1 254163062 8177304 complement(3199161..3200099) 1 NC_012967.1 regulates the tdcABCDEFG operon which is involved in amino acid degradation; DNA-binding transcriptional activator TdcA 3200099 tdcA 8177304 tdcA Escherichia coli B str. REL606 DNA-binding transcriptional activator TdcA YP_003046170.1 3199161 R 413997 CDS YP_003046171.1 254163063 8177305 3200414..3200632 1 NC_012967.1 participates in controlling the expression of several structural genes for the enzyme threonine dehydratase; TdcR activates the tdcABCDEFG operon; DNA-binding transcriptional activator TdcR 3200632 tdcR 8177305 tdcR Escherichia coli B str. REL606 DNA-binding transcriptional activator TdcR YP_003046171.1 3200414 D 413997 CDS YP_003046172.1 254163064 8177306 3200888..3201427 1 NC_012967.1 similar to b3120; hypothetical protein 3201427 yhaB 8177306 yhaB Escherichia coli B str. REL606 hypothetical protein YP_003046172.1 3200888 D 413997 CDS YP_003046173.1 254163065 8177307 3201449..3202552 1 NC_012967.1 similar to b3121; hypothetical protein 3202552 yhaC 8177307 yhaC Escherichia coli B str. REL606 hypothetical protein YP_003046173.1 3201449 D 413997 CDS YP_003046174.1 254163066 8179219 complement(3203554..3204780) 1 NC_012967.1 similar to b3124; glycerate kinase I 3204780 garK 8179219 garK Escherichia coli B str. REL606 glycerate kinase I YP_003046174.1 3203554 R 413997 CDS YP_003046175.1 254163067 8179220 complement(3204796..3205686) 1 NC_012967.1 catalyzes the reduction of tartronate semialdehyde to glycerate; tartronate semialdehyde reductase 3205686 garR 8179220 garR Escherichia coli B str. REL606 tartronate semialdehyde reductase YP_003046175.1 3204796 R 413997 CDS YP_003046176.1 254163068 8177308 complement(3205716..3206486) 1 NC_012967.1 cleaves 5-dehydro-4-deoxy-glucarate and 2-dehydro-3-deoxy-D-glucarate; alpha-dehydro-beta-deoxy-D-glucarate aldolase 3206486 garL 8177308 garL Escherichia coli B str. REL606 alpha-dehydro-beta-deoxy-D-glucarate aldolase YP_003046176.1 3205716 R 413997 CDS YP_003046177.1 254163069 8178687 complement(3206502..3207836) 1 NC_012967.1 similar to b3127; putative (D)-galactarate transporter 3207836 garP 8178687 garP Escherichia coli B str. REL606 putative (D)-galactarate transporter YP_003046177.1 3206502 R 413997 CDS YP_003046178.1 254163070 8177309 3208211..3209782 1 NC_012967.1 similar to b3128; (D)-galactarate dehydrogenase 3209782 garD 8177309 garD Escherichia coli B str. REL606 (D)-galactarate dehydrogenase YP_003046178.1 3208211 D 413997 CDS YP_003046179.1 254163071 8177310 3209930..3210265 1 NC_012967.1 SohA; PrlF; involved in protein secretion; when overproduced or mutated, it induces growth defect and increased export of a reporter protein; a PrlF mutation induces the activity of the Lon protease, and a Lon-deficient strain suppresses the phenotype conferred by the PrlF mutation; putative regulator PrlF 3210265 sohA 8177310 sohA Escherichia coli B str. REL606 putative regulator PrlF YP_003046179.1 3209930 D 413997 CDS YP_003046180.1 254163072 8177311 3210409..3210729 1 NC_012967.1 similar to b3130; hypothetical protein 3210729 yhaV 8177311 yhaV Escherichia coli B str. REL606 hypothetical protein YP_003046180.1 3210409 D 413997 CDS YP_003046181.1 254163073 8179221 complement(3210784..3211593) 1 NC_012967.1 transcriptional repressor for the agaZVWA and agaSYBCDI operons; DNA-binding transcriptional regulator AgaR 3211593 agaR 8179221 agaR Escherichia coli B str. REL606 DNA-binding transcriptional regulator AgaR YP_003046181.1 3210784 R 413997 CDS YP_003046182.1 254163074 8177312 3211842..3213122 1 NC_012967.1 similar to b3132; tagatose 6-phosphate aldolase 1, kbaZ subunit 3213122 agaZ 8177312 agaZ Escherichia coli B str. REL606 tagatose 6-phosphate aldolase 1, kbaZ subunit YP_003046182.1 3211842 D 413997 CDS YP_003046183.1 254163075 8179222 3213145..3213618 1 NC_012967.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake;involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIB 3213618 agaV 8179222 agaV Escherichia coli B str. REL606 PTS system N-acetylgalactosamine-specific transporter subunit IIB YP_003046183.1 3213145 D 413997 CDS YP_003046184.1 254163076 8177313 3213629..3214408 1 NC_012967.1 similar to b3134; N-acetylgalactosamine-specific PTS system transporter subunit IIC 3214408 agaW 8177313 agaW Escherichia coli B str. REL606 N-acetylgalactosamine-specific PTS system transporter subunit IIC YP_003046184.1 3213629 D 413997 CDS YP_003046185.1 254163077 8179223 3214398..3215276 1 NC_012967.1 PTS system, N-acetylgalactosamine-specific IID component 3215276 agaE 8179223 agaE Escherichia coli B str. REL606 PTS system, N-acetylgalactosamine-specific IID component YP_003046185.1 3214398 D 413997 CDS YP_003046186.1 254163078 8179224 3215294..3215728 1 NC_012967.1 putative phosphotransferase system enzyme subunit (N-acetyl-galactosamine/galactosamine PTS system enzyme IIA component) 3215728 agaF 8179224 agaF Escherichia coli B str. REL606 putative phosphotransferase system enzyme subunit (N-acetyl-galactosamine/galactosamine PTS system enzyme IIA component) YP_003046186.1 3215294 D 413997 CDS YP_003046187.1 254163079 8177314 3215725..3216858 1 NC_012967.1 similar to b3135; N-acetylgalactosamine-6-phosphate deacetylase 3216858 agaA 8177314 agaA Escherichia coli B str. REL606 N-acetylgalactosamine-6-phosphate deacetylase YP_003046187.1 3215725 D 413997 CDS YP_003046188.1 254163080 8177315 3217209..3218363 1 NC_012967.1 similar to b3136; tagatose-6-phosphate ketose/aldose isomerase 3218363 agaS 8177315 agaS Escherichia coli B str. REL606 tagatose-6-phosphate ketose/aldose isomerase YP_003046188.1 3217209 D 413997 CDS YP_003046189.1 254163081 8178688 3218376..3219236 1 NC_012967.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway; tagatose-bisphosphate aldolase 3219236 kbaY 8178688 kbaY Escherichia coli B str. REL606 tagatose-bisphosphate aldolase YP_003046189.1 3218376 D 413997 CDS YP_003046190.1 254163082 8178689 3219403..3219879 1 NC_012967.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIB 3219879 agaB 8178689 agaB Escherichia coli B str. REL606 PTS system N-acetylgalactosamine-specific transporter subunit IIB YP_003046190.1 3219403 D 413997 CDS YP_003046191.1 254163083 8177316 3219918..3220721 1 NC_012967.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane;protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIC 3220721 agaC 8177316 agaC Escherichia coli B str. REL606 PTS system N-acetylgalactosamine-specific transporter subunit IIC YP_003046191.1 3219918 D 413997 CDS YP_003046192.1 254163084 8178690 3220711..3221502 1 NC_012967.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IID 3221502 agaD 8178690 agaD Escherichia coli B str. REL606 PTS system N-acetylgalactosamine-specific transporter subunit IID YP_003046192.1 3220711 D 413997 CDS YP_003046193.1 254163085 8177317 3221503..3222258 1 NC_012967.1 similar to b3141; galactosamine-6-phosphate isomerase 3222258 agaI 8177317 agaI Escherichia coli B str. REL606 galactosamine-6-phosphate isomerase YP_003046193.1 3221503 D 413997 CDS YP_003046194.1 254163086 8177318 3222659..3223243 1 NC_012967.1 similar to b3142; putative fimbrial-like adhesin protein 3223243 yraH 8177318 yraH Escherichia coli B str. REL606 putative fimbrial-like adhesin protein YP_003046194.1 3222659 D 413997 CDS YP_003046195.1 254163087 8177319 3223323..3224018 1 NC_012967.1 similar to b3143; putative periplasmic pilin chaperone 3224018 yraI 8177319 yraI Escherichia coli B str. REL606 putative periplasmic pilin chaperone YP_003046195.1 3223323 D 413997 CDS YP_003046196.1 254163088 8177320 3224048..3226564 1 NC_012967.1 similar to b3144; putative outer membrane protein 3226564 yraJ 8177320 yraJ Escherichia coli B str. REL606 putative outer membrane protein YP_003046196.1 3224048 D 413997 CDS YP_003046197.1 254163089 8177321 3226575..3227666 1 NC_012967.1 similar to b3145; putative fimbrial-like adhesin protein 3227666 yraK 8177321 yraK Escherichia coli B str. REL606 putative fimbrial-like adhesin protein YP_003046197.1 3226575 D 413997 CDS YP_003046198.1 254163090 8177322 complement(3227709..3228569) 1 NC_012967.1 similar to b3146; putative methyltransferase 3228569 yraL 8177322 yraL Escherichia coli B str. REL606 putative methyltransferase YP_003046198.1 3227709 R 413997 CDS YP_003046199.1 254163091 8178691 3228634..3230670 1 NC_012967.1 similar to b3147; hypothetical protein 3230670 yraM 8178691 yraM Escherichia coli B str. REL606 hypothetical protein YP_003046199.1 3228634 D 413997 CDS YP_003046200.1 254163092 8177323 3230628..3231023 1 NC_012967.1 similar to b3148; hypothetical protein 3231023 yraN 8177323 yraN Escherichia coli B str. REL606 hypothetical protein YP_003046200.1 3230628 D 413997 CDS YP_003046201.1 254163093 8178692 3231043..3231633 1 NC_012967.1 Required for the timely initiation of chromosomal replication via direct interactions with the dnaA initiator protein; DnaA initiator-associating protein DiaA 3231633 yraO 8178692 yraO Escherichia coli B str. REL606 DnaA initiator-associating protein DiaA YP_003046201.1 3231043 D 413997 CDS YP_003046202.1 254163094 8178693 3231643..3232218 1 NC_012967.1 similar to b3150; hypothetical protein 3232218 yraP 8178693 yraP Escherichia coli B str. REL606 hypothetical protein YP_003046202.1 3231643 D 413997 CDS YP_003046203.1 254163095 8177324 complement(3232332..3233372) 1 NC_012967.1 similar to b3151; putative permease 3233372 yraQ 8177324 yraQ Escherichia coli B str. REL606 putative permease YP_003046203.1 3232332 R 413997 CDS YP_003046204.1 254163096 8177325 complement(3233445..3234080) 1 NC_012967.1 similar to b3152; putative nucleoside-diphosphate-sugar epimerase 3234080 yraR 8177325 yraR Escherichia coli B str. REL606 putative nucleoside-diphosphate-sugar epimerase YP_003046204.1 3233445 R 413997 CDS YP_003046205.1 254163097 8177326 3234208..3234726 1 NC_012967.1 similar to b3153; putative intracellular protease 3234726 yhbO 8177326 yhbO Escherichia coli B str. REL606 putative intracellular protease YP_003046205.1 3234208 D 413997 CDS YP_003046206.1 254163098 8177327 complement(3234706..3235149) 1 NC_012967.1 similar to b3154; hypothetical protein 3235149 yhbP 8177327 yhbP Escherichia coli B str. REL606 hypothetical protein YP_003046206.1 3234706 R 413997 CDS YP_003046207.1 254163099 8179225 3235200..3235502 1 NC_012967.1 similar to b3155; GIY-YIG nuclease superfamily protein 3235502 yhbQ 8179225 yhbQ Escherichia coli B str. REL606 GIY-YIG nuclease superfamily protein YP_003046207.1 3235200 D 413997 CDS YP_003046208.1 254163100 8177328 complement(3235489..3235992) 1 NC_012967.1 similar to b3156; putative acyltransferase with acyl-CoA N-acyltransferase domain 3235992 yhbS 8177328 yhbS Escherichia coli B str. REL606 putative acyltransferase with acyl-CoA N-acyltransferase domain YP_003046208.1 3235489 R 413997 CDS YP_003046209.1 254163101 8177329 complement(3235986..3236510) 1 NC_012967.1 similar to b3157; putative lipid carrier protein 3236510 yhbT 8177329 yhbT Escherichia coli B str. REL606 putative lipid carrier protein YP_003046209.1 3235986 R 413997 CDS YP_003046210.1 254163102 8177330 3236719..3237714 1 NC_012967.1 similar to b3158; putative peptidase (collagenase-like) 3237714 yhbU 8177330 yhbU Escherichia coli B str. REL606 putative peptidase (collagenase-like) YP_003046210.1 3236719 D 413997 CDS YP_003046211.1 254163103 8177331 3237723..3238601 1 NC_012967.1 similar to b3159; putative protease 3238601 yhbV 8177331 yhbV Escherichia coli B str. REL606 putative protease YP_003046211.1 3237723 D 413997 CDS YP_003046212.1 254163104 8177332 3238682..3239689 1 NC_012967.1 similar to b3160; hypothetical protein 3239689 yhbW 8177332 yhbW Escherichia coli B str. REL606 hypothetical protein YP_003046212.1 3238682 D 413997 CDS YP_003046213.1 254163105 8177333 complement(3239807..3241051) 1 NC_012967.1 tryptophan transporter of high affinity; tryptophan permease 3241051 mtr 8177333 mtr Escherichia coli B str. REL606 tryptophan permease YP_003046213.1 3239807 R 413997 CDS YP_003046214.1 254163106 8177334 complement(3241205..3243094) 1 NC_012967.1 participates in the assembly of the large subunit of the ribosome; plays a key role in optimal cell growth at low temperature and is required for normal cell division; ATP-dependent RNA helicase DeaD 3243094 deaD 8177334 deaD Escherichia coli B str. REL606 ATP-dependent RNA helicase DeaD YP_003046214.1 3241205 R 413997 CDS YP_003046215.1 254163107 8177335 complement(3243274..3244158) 1 NC_012967.1 lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing; lipoprotein NlpI 3244158 nlpI 8177335 nlpI Escherichia coli B str. REL606 lipoprotein NlpI YP_003046215.1 3243274 R 413997 CDS YP_003046216.1 254163108 8177336 complement(3244267..3246471) 1 NC_012967.1 similar to b3164; polynucleotide phosphorylase/polyadenylase 3246471 pnp 8177336 pnp Escherichia coli B str. REL606 polynucleotide phosphorylase/polyadenylase YP_003046216.1 3244267 R 413997 CDS YP_003046217.1 254163109 8177337 complement(3246649..3246918) 1 NC_012967.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 3246918 rpsO 8177337 rpsO Escherichia coli B str. REL606 30S ribosomal protein S15 YP_003046217.1 3246649 R 413997 CDS YP_003046218.1 254163110 8177338 complement(3247067..3248011) 1 NC_012967.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 3248011 truB 8177338 truB Escherichia coli B str. REL606 tRNA pseudouridine synthase B YP_003046218.1 3247067 R 413997 CDS YP_003046219.1 254163111 8178694 complement(3248011..3248412) 1 NC_012967.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 3248412 rbfA 8178694 rbfA Escherichia coli B str. REL606 ribosome-binding factor A YP_003046219.1 3248011 R 413997 CDS YP_003046220.1 254163112 8179226 complement(3248576..3251248) 1 NC_012967.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 3251248 infB 8179226 infB Escherichia coli B str. REL606 translation initiation factor IF-2 YP_003046220.1 3248576 R 413997 CDS YP_003046221.1 254163113 8177339 complement(3251273..3252760) 1 NC_012967.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 3252760 nusA 8177339 nusA Escherichia coli B str. REL606 transcription elongation factor NusA YP_003046221.1 3251273 R 413997 CDS YP_003046222.1 254163114 8177340 complement(3252788..3253240) 1 NC_012967.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 3253240 yhbC 8177340 yhbC Escherichia coli B str. REL606 hypothetical protein YP_003046222.1 3252788 R 413997 CDS YP_003046223.1 254163115 8177342 3253871..3255214 1 NC_012967.1 catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis; argininosuccinate synthase 3255214 argG 8177342 argG Escherichia coli B str. REL606 argininosuccinate synthase YP_003046223.1 3253871 D 413997 CDS YP_003046224.1 254163116 8177343 complement(3255222..3256847) 1 NC_012967.1 similar to b3173; putative hydrolase, inner membrane 3256847 yhbX 8177343 yhbX Escherichia coli B str. REL606 putative hydrolase, inner membrane YP_003046224.1 3255222 R 413997 CDS YP_003046225.1 254163117 8179227 complement(3257407..3257739) 1 NC_012967.1 similar to b3175; preprotein translocase subunit SecG 3257739 secG 8179227 secG Escherichia coli B str. REL606 preprotein translocase subunit SecG YP_003046225.1 3257407 R 413997 CDS YP_003046226.1 254163118 8177345 complement(3257967..3259304) 1 NC_012967.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 3259304 glmM 8177345 glmM Escherichia coli B str. REL606 phosphoglucosamine mutase YP_003046226.1 3257967 R 413997 CDS YP_003046227.1 254163119 8177346 complement(3259297..3260145) 1 NC_012967.1 catalyzes the formation of dihydropteroate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate; dihydropteroate synthase 3260145 folP 8177346 folP Escherichia coli B str. REL606 dihydropteroate synthase YP_003046227.1 3259297 R 413997 CDS YP_003046228.1 254163120 8177347 complement(3260235..3262169) 1 NC_012967.1 inner membrane metalloprotease; may be involved in degradation of aberrant cytoplasmic and membrane proteins; ATP-dependent metalloprotease 3262169 hflB 8177347 hflB Escherichia coli B str. REL606 ATP-dependent metalloprotease YP_003046228.1 3260235 R 413997 CDS YP_003046229.1 254163121 8179228 complement(3262269..3262898) 1 NC_012967.1 Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit; 23S rRNA methyltransferase J 3262898 rrmJ 8179228 rrmJ Escherichia coli B str. REL606 23S rRNA methyltransferase J YP_003046229.1 3262269 R 413997 CDS YP_003046230.1 254163122 8177348 3263024..3263317 1 NC_012967.1 RNA binding protein found associated to pre-50S subunit of the ribosome; putative role in ribosome assembly; necessary for optimal growth but not cell viability; RNA-binding protein YhbY 3263317 yhbY 8177348 yhbY Escherichia coli B str. REL606 RNA-binding protein YhbY YP_003046230.1 3263024 D 413997 CDS YP_003046231.1 254163123 8177349 complement(3263473..3263949) 1 NC_012967.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 3263949 greA 8177349 greA Escherichia coli B str. REL606 transcription elongation factor GreA YP_003046231.1 3263473 R 413997 CDS YP_003046232.1 254163124 8179229 3264197..3265630 1 NC_012967.1 penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase/endopeptidase 3265630 dacB 8179229 dacB Escherichia coli B str. REL606 D-alanyl-D-alanine carboxypeptidase/endopeptidase YP_003046232.1 3264197 D 413997 CDS YP_003046233.1 254163125 8177350 complement(3265816..3266988) 1 NC_012967.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 3266988 obgE 8177350 obgE Escherichia coli B str. REL606 GTPase ObgE YP_003046233.1 3265816 R 413997 CDS YP_003046234.1 254163126 8177351 complement(3267004..3267969) 1 NC_012967.1 similar to b3184; inner membrane protein 3267969 yhbE 8177351 yhbE Escherichia coli B str. REL606 inner membrane protein YP_003046234.1 3267004 R 413997 CDS YP_003046235.1 254163127 8178695 complement(3268096..3268353) 1 NC_012967.1 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 3268353 rpmA 8178695 rpmA Escherichia coli B str. REL606 50S ribosomal protein L27 YP_003046235.1 3268096 R 413997 CDS YP_003046236.1 254163128 8178696 complement(3268374..3268685) 1 NC_012967.1 similar to b3186; 50S ribosomal protein L21 3268685 rplU 8178696 rplU Escherichia coli B str. REL606 50S ribosomal protein L21 YP_003046236.1 3268374 R 413997 CDS YP_003046237.1 254163129 8177352 3268944..3269915 1 NC_012967.1 similar to b3187; octaprenyl diphosphate synthase 3269915 ispB 8177352 ispB Escherichia coli B str. REL606 octaprenyl diphosphate synthase YP_003046237.1 3268944 D 413997 CDS YP_003046238.1 254163130 8179230 3270144..3270422 1 NC_012967.1 activator of maltose metabolism genes; DNA-binding transcriptional regulator Nlp 3270422 nlp 8179230 nlp Escherichia coli B str. REL606 DNA-binding transcriptional regulator Nlp YP_003046238.1 3270144 D 413997 CDS YP_003046239.1 254163131 8177353 complement(3270470..3271729) 1 NC_012967.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 3271729 murA 8177353 murA Escherichia coli B str. REL606 UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_003046239.1 3270470 R 413997 CDS YP_003046240.1 254163132 8177354 complement(3271784..3272038) 1 NC_012967.1 similar to b3190; putative DNA-binding transcriptional regulator 3272038 yrbA 8177354 yrbA Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003046240.1 3271784 R 413997 CDS YP_003046241.1 254163133 8177355 complement(3272198..3272491) 1 NC_012967.1 similar to b3191; hypothetical protein 3272491 yrbB 8177355 yrbB Escherichia coli B str. REL606 hypothetical protein YP_003046241.1 3272198 R 413997 CDS YP_003046242.1 254163134 8179231 complement(3272491..3273126) 1 NC_012967.1 similar to b3192; putative ABC-type organic solvent transporter 3273126 yrbC 8179231 yrbC Escherichia coli B str. REL606 putative ABC-type organic solvent transporter YP_003046242.1 3272491 R 413997 CDS YP_003046243.1 254163135 8177356 complement(3273145..3273696) 1 NC_012967.1 similar to b3193; putative ABC-type organic solvent transporter 3273696 yrbD 8177356 yrbD Escherichia coli B str. REL606 putative ABC-type organic solvent transporter YP_003046243.1 3273145 R 413997 CDS YP_003046244.1 254163136 8177357 complement(3273701..3274483) 1 NC_012967.1 similar to b3194; putative toluene transporter subunit membrane component of ABC superfamily 3274483 yrbE 8177357 yrbE Escherichia coli B str. REL606 putative toluene transporter subunit membrane component of ABC superfamily YP_003046244.1 3273701 R 413997 CDS YP_003046245.1 254163137 8177358 complement(3274491..3275300) 1 NC_012967.1 ATP-binding subunit of a putative ABC toluene efflux transporter; putative ABC transporter ATP-binding protein YrbF 3275300 yrbF 8177358 yrbF Escherichia coli B str. REL606 putative ABC transporter ATP-binding protein YrbF YP_003046245.1 3274491 R 413997 CDS YP_003046246.1 254163138 8177359 3275510..3276487 1 NC_012967.1 YrbG; inner membrane protein involved in cell envelope integrity; putative sodium ion/calcium ion exchanger; in E. coli it is non essential for cell viability; member of the YRBG family of cation/Ca2+ exchangers; putative calcium/sodium:proton antiporter 3276487 yrbG 8177359 yrbG Escherichia coli B str. REL606 putative calcium/sodium:proton antiporter YP_003046246.1 3275510 D 413997 CDS YP_003046247.1 254163139 8177360 3276501..3277487 1 NC_012967.1 similar to b3197; D-arabinose 5-phosphate isomerase 3277487 yrbH 8177360 yrbH Escherichia coli B str. REL606 D-arabinose 5-phosphate isomerase YP_003046247.1 3276501 D 413997 CDS YP_003046248.1 254163140 8177361 3277508..3278074 1 NC_012967.1 forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase 3278074 yrbI 8177361 yrbI Escherichia coli B str. REL606 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase YP_003046248.1 3277508 D 413997 CDS YP_003046249.1 254163141 8179232 3278071..3278646 1 NC_012967.1 similar to b3199; hypothetical protein 3278646 yrbK 8179232 yrbK Escherichia coli B str. REL606 hypothetical protein YP_003046249.1 3278071 D 413997 CDS YP_003046250.1 254163142 8177362 3278615..3279172 1 NC_012967.1 LptA; periplasmic binding protein part of a putative ABC superfamily of uptake transporters; interacts with LptB protein, the ATP binding component of the uptake system; lipopolysaccharide transport periplasmic protein LptA 3279172 yhbN 8177362 yhbN Escherichia coli B str. REL606 lipopolysaccharide transport periplasmic protein LptA YP_003046250.1 3278615 D 413997 CDS YP_003046251.1 254163143 8177363 3279179..3279904 1 NC_012967.1 similar to b3201; putative ABC transporter ATP-binding protein YhbG 3279904 yhbG 8177363 yhbG Escherichia coli B str. REL606 putative ABC transporter ATP-binding protein YhbG YP_003046251.1 3279179 D 413997 CDS YP_003046252.1 254163144 8177364 3279952..3281385 1 NC_012967.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen; RNA polymerase factor sigma-54 3281385 rpoN 8177364 rpoN Escherichia coli B str. REL606 RNA polymerase factor sigma-54 YP_003046252.1 3279952 D 413997 CDS YP_003046253.1 254163145 8177365 3281408..3281695 1 NC_012967.1 YhbH; resting ribosome-binding protein involved in ribosome stabilization and preservation in stationary phase; binds specifically 100S ribosomes (an inactive ribosome product of a 70S ribosome dimerization); seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing; putative sigma(54) modulation protein 3281695 yhbH 8177365 yhbH Escherichia coli B str. REL606 putative sigma(54) modulation protein YP_003046253.1 3281408 D 413997 CDS YP_003046254.1 254163146 8177366 3281813..3282304 1 NC_012967.1 similar to b3204; PTS system transporter subunit IIA-like nitrogen-regulatory protein PtsN 3282304 ptsN 8177366 ptsN Escherichia coli B str. REL606 PTS system transporter subunit IIA-like nitrogen-regulatory protein PtsN YP_003046254.1 3281813 D 413997 CDS YP_003046255.1 254163147 8178697 3282350..3283204 1 NC_012967.1 similar to b3205; hypothetical protein 3283204 yhbJ 8178697 yhbJ Escherichia coli B str. REL606 hypothetical protein YP_003046255.1 3282350 D 413997 CDS YP_003046256.1 254163148 8178698 3283201..3283473 1 NC_012967.1 similar to b3206; phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) 3283473 ptsO 8178698 ptsO Escherichia coli B str. REL606 phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) YP_003046256.1 3283201 D 413997 CDS YP_003046257.1 254163149 8177367 3283687..3284319 1 NC_012967.1 similar to b3207; hypothetical protein 3284319 yrbL 8177367 yrbL Escherichia coli B str. REL606 hypothetical protein YP_003046257.1 3283687 D 413997 CDS YP_003046258.1 254163150 8178699 complement(3284316..3285044) 1 NC_012967.1 glycosyltransferase; polymerizes glycan strands in the peptidoglycan; monofunctional biosynthetic peptidoglycan transglycosylase 3285044 mtgA 8178699 mtgA Escherichia coli B str. REL606 monofunctional biosynthetic peptidoglycan transglycosylase YP_003046258.1 3284316 R 413997 CDS YP_003046259.1 254163151 8177368 complement(3285041..3285694) 1 NC_012967.1 similar to b3209; isoprenoid biosynthesis protein with amidotransferase-like domain 3285694 yhbL 8177368 yhbL Escherichia coli B str. REL606 isoprenoid biosynthesis protein with amidotransferase-like domain YP_003046259.1 3285041 R 413997 CDS YP_003046260.1 254163152 8177369 complement(3285924..3288260) 1 NC_012967.1 sensor-regulator protein which regulates the expression of many genes in response to respiratory growth conditions including anaerobic repression of the arc modulon; hybrid sensory histidine kinase in two-component regulatory system with ArcA; aerobic respiration control sensor protein ArcB 3288260 arcB 8177369 arcB Escherichia coli B str. REL606 aerobic respiration control sensor protein ArcB YP_003046260.1 3285924 R 413997 CDS YP_003046261.1 254163153 8177370 complement(3288356..3289285) 1 NC_012967.1 similar to b3211; putative Fe-S oxidoreductase 3289285 yhcC 8177370 yhcC Escherichia coli B str. REL606 putative Fe-S oxidoreductase YP_003046261.1 3288356 R 413997 CDS YP_003046262.1 254163154 8177371 3289867..3294420 1 NC_012967.1 catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate; glutamate synthase subunit alpha 3294420 gltB 8177371 gltB Escherichia coli B str. REL606 glutamate synthase subunit alpha YP_003046262.1 3289867 D 413997 CDS YP_003046263.1 254163155 8179233 3294433..3295851 1 NC_012967.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; glutamate synthase subunit beta 3295851 gltD 8179233 gltD Escherichia coli B str. REL606 glutamate synthase subunit beta YP_003046263.1 3294433 D 413997 CDS YP_003046264.1 254163156 8177372 3296035..3296514 1 NC_012967.1 similar to b3220; hypothetical protein 3296514 yhcG 8177372 yhcG Escherichia coli B str. REL606 hypothetical protein YP_003046264.1 3296035 D 413997 CDS YP_003046265.1 254163157 8177373 3296495..3296836 1 NC_012967.1 IS600 orf-like protein 3296836 8177373 ECB_03080 Escherichia coli B str. REL606 IS600 orf-like protein YP_003046265.1 3296495 D 413997 CDS YP_003046266.1 254163158 8179234 complement(3296912..3297376) 1 NC_012967.1 similar to b3221; hypothetical protein 3297376 yhcH 8179234 yhcH Escherichia coli B str. REL606 hypothetical protein YP_003046266.1 3296912 R 413997 CDS YP_003046267.1 254163159 8177374 complement(3297373..3298248) 1 NC_012967.1 catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein; N-acetylmannosamine kinase 3298248 nanK 8177374 nanK Escherichia coli B str. REL606 N-acetylmannosamine kinase YP_003046267.1 3297373 R 413997 CDS YP_003046268.1 254163160 8177375 complement(3298245..3298934) 1 NC_012967.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase 3298934 nanE 8177375 nanE Escherichia coli B str. REL606 N-acetylmannosamine-6-phosphate 2-epimerase YP_003046268.1 3298245 R 413997 CDS YP_003046269.1 254163161 8177376 complement(3298982..3300472) 1 NC_012967.1 similar to b3224; putative sialic acid transporter 3300472 nanT 8177376 nanT Escherichia coli B str. REL606 putative sialic acid transporter YP_003046269.1 3298982 R 413997 CDS YP_003046270.1 254163162 8177377 complement(3300581..3301474) 1 NC_012967.1 catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid; N-acetylneuraminate lyase 3301474 nanA 8177377 nanA Escherichia coli B str. REL606 N-acetylneuraminate lyase YP_003046270.1 3300581 R 413997 CDS YP_003046271.1 254163163 8177378 complement(3301596..3302387) 1 NC_012967.1 Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization; transcriptional regulator NanR 3302387 nanR 8177378 nanR Escherichia coli B str. REL606 transcriptional regulator NanR YP_003046271.1 3301596 R 413997 CDS YP_003046272.1 254163164 8177379 3302767..3304134 1 NC_012967.1 YhcL; uncharacterized member of the DcuC family of anaerobic dicarboxylate transporters; probable role in transport of carboxylates across the inner membrane from the periplasm; its encoding gene is not essential for growth and is probably cryptic; putative cryptic C4-dicarboxylate transporter DcuD 3304134 dcuD 8177379 dcuD Escherichia coli B str. REL606 putative cryptic C4-dicarboxylate transporter DcuD YP_003046272.1 3302767 D 413997 CDS YP_003046273.1 254163165 8178700 complement(3304177..3304674) 1 NC_012967.1 similar to b3228; ClpXP protease specificity-enhancing factor 3304674 sspB 8178700 sspB Escherichia coli B str. REL606 ClpXP protease specificity-enhancing factor YP_003046273.1 3304177 R 413997 CDS YP_003046274.1 254163166 8177380 complement(3304680..3305318) 1 NC_012967.1 transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation; stringent starvation protein A 3305318 sspA 8177380 sspA Escherichia coli B str. REL606 stringent starvation protein A YP_003046274.1 3304680 R 413997 CDS YP_003046275.1 254163167 8177381 complement(3305713..3306105) 1 NC_012967.1 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 3306105 rpsI 8177381 rpsI Escherichia coli B str. REL606 30S ribosomal protein S9 YP_003046275.1 3305713 R 413997 CDS YP_003046276.1 254163168 8177382 complement(3306121..3306549) 1 NC_012967.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 3306549 rplM 8177382 rplM Escherichia coli B str. REL606 50S ribosomal protein L13 YP_003046276.1 3306121 R 413997 CDS YP_003046277.1 254163169 8178701 complement(3306768..3307895) 1 NC_012967.1 similar to b3232; hypothetical protein 3307895 yhcM 8178701 yhcM Escherichia coli B str. REL606 hypothetical protein YP_003046277.1 3306768 R 413997 CDS YP_003046278.1 254163170 8177383 3308089..3308487 1 NC_012967.1 similar to b3233; cytochrome d ubiquinol oxidase subunit III 3308487 yhcB 8177383 yhcB Escherichia coli B str. REL606 cytochrome d ubiquinol oxidase subunit III YP_003046278.1 3308089 D 413997 CDS YP_003046279.1 254163171 8177384 3308641..3310008 1 NC_012967.1 similar to b3234; serine endoprotease 3310008 degQ 8177384 degQ Escherichia coli B str. REL606 serine endoprotease YP_003046279.1 3308641 D 413997 CDS YP_003046280.1 254163172 8178702 3310098..3311165 1 NC_012967.1 similar to b3235; serine endoprotease 3311165 degS 8178702 degS Escherichia coli B str. REL606 serine endoprotease YP_003046280.1 3310098 D 413997 CDS YP_003046281.1 254163173 8177385 complement(3311227..3312165) 1 NC_012967.1 oxidizes malate to oxaloacetate; malate dehydrogenase 3312165 mdh 8177385 mdh Escherichia coli B str. REL606 malate dehydrogenase YP_003046281.1 3311227 R 413997 CDS YP_003046282.1 254163174 8177386 3312600..3313070 1 NC_012967.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor 3313070 argR 8177386 argR Escherichia coli B str. REL606 arginine repressor YP_003046282.1 3312600 D 413997 CDS YP_003046283.1 254163175 8177387 3313435..3313698 1 NC_012967.1 similar to b3238; hypothetical protein 3313698 yhcN 8177387 yhcN Escherichia coli B str. REL606 hypothetical protein YP_003046283.1 3313435 D 413997 CDS YP_003046284.1 254163176 8177388 complement(3313754..3314026) 1 NC_012967.1 similar to b3239; putative barnase inhibitor 3314026 yhcO 8177388 yhcO Escherichia coli B str. REL606 putative barnase inhibitor YP_003046284.1 3313754 R 413997 CDS YP_003046285.1 254163177 8179235 complement(3314118..3316085) 1 NC_012967.1 with AaeA forms an efflux pump whose substrates are p-hydroxybenzoic acid 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeB 3316085 yhcP 8179235 yhcP Escherichia coli B str. REL606 p-hydroxybenzoic acid efflux subunit AaeB YP_003046285.1 3314118 R 413997 CDS YP_003046286.1 254163178 8177389 complement(3316091..3317023) 1 NC_012967.1 with AaeB forms an efflux pump whose substrates are p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeA 3317023 yhcQ 8177389 yhcQ Escherichia coli B str. REL606 p-hydroxybenzoic acid efflux subunit AaeA YP_003046286.1 3316091 R 413997 CDS YP_003046287.1 254163179 8177390 complement(3317031..3317234) 1 NC_012967.1 membrane protein AaeX; the gene is a member of the aaeXAB operon; hypothetical protein 3317234 yhcR 8177390 yhcR Escherichia coli B str. REL606 hypothetical protein YP_003046287.1 3317031 R 413997 CDS YP_003046288.1 254163180 8177391 3317417..3318346 1 NC_012967.1 similar to b3243; putative DNA-binding transcriptional regulator 3318346 yhcS 8177391 yhcS Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003046288.1 3317417 D 413997 CDS YP_003046289.1 254163181 8177392 complement(3318474..3319919) 1 NC_012967.1 responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase; degrades the E. coli plasmid F-encoded CcdA; protease TldD 3319919 tldD 8177392 tldD Escherichia coli B str. REL606 protease TldD YP_003046289.1 3318474 R 413997 CDS YP_003046290.1 254163182 8177393 complement(3320349..3324149) 1 NC_012967.1 similar to b4472; hypothetical protein 3324149 yhdP 8177393 yhdP Escherichia coli B str. REL606 hypothetical protein YP_003046290.1 3320349 R 413997 CDS YP_003046291.1 254163183 8177394 complement(3324217..3325686) 1 NC_012967.1 involved in the processing of the 5'end of 16S rRNA; ribonuclease G 3325686 rng 8177394 rng Escherichia coli B str. REL606 ribonuclease G YP_003046291.1 3324217 R 413997 CDS YP_003046292.1 254163184 8177395 complement(3325676..3326269) 1 NC_012967.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 3326269 yhdE 8177395 yhdE Escherichia coli B str. REL606 Maf-like protein YP_003046292.1 3325676 R 413997 CDS YP_003046293.1 254163185 8177396 complement(3326278..3326766) 1 NC_012967.1 part of cell wall structural complex MreBCD; transmembrane component; rod shape-determining protein MreD 3326766 mreD 8177396 mreD Escherichia coli B str. REL606 rod shape-determining protein MreD YP_003046293.1 3326278 R 413997 CDS YP_003046294.1 254163186 8177397 complement(3326766..3327869) 1 NC_012967.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC 3327869 mreC 8177397 mreC Escherichia coli B str. REL606 rod shape-determining protein MreC YP_003046294.1 3326766 R 413997 CDS YP_003046295.1 254163187 8177398 complement(3327935..3328978) 1 NC_012967.1 functions in MreBCD complex in some organisms; rod shape-determining protein MreB 3328978 mreB 8177398 mreB Escherichia coli B str. REL606 rod shape-determining protein MreB YP_003046295.1 3327935 R 413997 CDS YP_003046296.1 254163188 8177399 complement(3329283..3331223) 1 NC_012967.1 regulates the degradation of the small RNAs CsrB and CsrC; may function to targate RNase E to specific RNA molecules; regulatory protein CsrD 3331223 yhdA 8177399 yhdA Escherichia coli B str. REL606 regulatory protein CsrD YP_003046296.1 3329283 R 413997 CDS YP_003046297.1 254163189 8178703 3331375..3332349 1 NC_012967.1 similar to b3253; putative oxidoreductase, Zn-dependent and NAD(P)-binding 3332349 yhdH 8178703 yhdH Escherichia coli B str. REL606 putative oxidoreductase, Zn-dependent and NAD(P)-binding YP_003046297.1 3331375 D 413997 CDS YP_003046298.1 254163190 8177400 3333327..3333797 1 NC_012967.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 3333797 accB 8177400 accB Escherichia coli B str. REL606 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit YP_003046298.1 3333327 D 413997 CDS YP_003046299.1 254163191 8178704 3333808..3335157 1 NC_012967.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 3335157 accC 8178704 accC Escherichia coli B str. REL606 acetyl-CoA carboxylase biotin carboxylase subunit YP_003046299.1 3333808 D 413997 CDS YP_003046300.1 254163192 8177401 3335266..3335508 1 NC_012967.1 similar to b3257; hypothetical protein 3335508 yhdT 8177401 yhdT Escherichia coli B str. REL606 hypothetical protein YP_003046300.1 3335266 D 413997 CDS YP_003046301.1 254163193 8177402 3335498..3336949 1 NC_012967.1 mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase; sodium/panthothenate symporter 3336949 panF 8177402 panF Escherichia coli B str. REL606 sodium/panthothenate symporter YP_003046301.1 3335498 D 413997 CDS YP_003046302.1 254163194 8179236 3336961..3337842 1 NC_012967.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; ribosomal protein L11 methyltransferase 3337842 prmA 8179236 prmA Escherichia coli B str. REL606 ribosomal protein L11 methyltransferase YP_003046302.1 3336961 D 413997 CDS YP_003046303.1 254163195 8177403 3338171..3339136 1 NC_012967.1 similar to b3260; tRNA-dihydrouridine synthase B 3339136 yhdG 8177403 yhdG Escherichia coli B str. REL606 tRNA-dihydrouridine synthase B YP_003046303.1 3338171 D 413997 CDS YP_003046304.1 254163196 8177404 3339162..3339458 1 NC_012967.1 Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription; DNA-binding protein Fis 3339458 fis 8177404 fis Escherichia coli B str. REL606 DNA-binding protein Fis YP_003046304.1 3339162 D 413997 CDS YP_003046305.1 254163197 8179237 3339544..3340428 1 NC_012967.1 similar to b3262; putative methyltransferase 3340428 yhdJ 8179237 yhdJ Escherichia coli B str. REL606 putative methyltransferase YP_003046305.1 3339544 D 413997 CDS YP_003046306.1 254163198 8177405 3340512..3340691 1 NC_012967.1 similar to b3263; hypothetical protein 3340691 yhdU 8177405 yhdU Escherichia coli B str. REL606 hypothetical protein YP_003046306.1 3340512 D 413997 CDS YP_003046307.1 254163199 8177406 complement(3340694..3341356) 1 NC_012967.1 similar to b3264; DNA-binding transcriptional regulator EnvR 3341356 envR 8177406 envR Escherichia coli B str. REL606 DNA-binding transcriptional regulator EnvR YP_003046307.1 3340694 R 413997 CDS YP_003046308.1 254163200 8177407 3341755..3342912 1 NC_012967.1 similar to b3265; cytoplasmic membrane lipoprotein 3342912 acrE 8177407 acrE Escherichia coli B str. REL606 cytoplasmic membrane lipoprotein YP_003046308.1 3341755 D 413997 CDS YP_003046309.1 254163201 8178705 3342924..3346028 1 NC_012967.1 similar to b3266; multidrug efflux system protein 3346028 acrF 8178705 acrF Escherichia coli B str. REL606 multidrug efflux system protein YP_003046309.1 3342924 D 413997 CDS YP_003046310.1 254163202 8177408 3346281..3346502 1 NC_012967.1 similar to b3267; putative outer membrane protein 3346502 yhdV 8177408 yhdV Escherichia coli B str. REL606 putative outer membrane protein YP_003046310.1 3346281 D 413997 CDS YP_003046311.1 254163203 8177409 3347041..3347958 1 NC_012967.1 similar to b3268; putative amino-acid transporter subunit 3347958 yhdW 8177409 yhdW Escherichia coli B str. REL606 putative amino-acid transporter subunit YP_003046311.1 3347041 D 413997 CDS YP_003046312.1 254163204 8178706 3348026..3349207 1 NC_012967.1 similar to b3269; putative amino-acid transporter subunit 3349207 yhdX 8178706 yhdX Escherichia coli B str. REL606 putative amino-acid transporter subunit YP_003046312.1 3348026 D 413997 CDS YP_003046313.1 254163205 8177410 3349217..3350320 1 NC_012967.1 similar to b3270; putative amino-acid transporter subunit 3350320 yhdY 8177410 yhdY Escherichia coli B str. REL606 putative amino-acid transporter subunit YP_003046313.1 3349217 D 413997 CDS YP_003046314.1 254163206 8177411 3350328..3351086 1 NC_012967.1 similar to b3271; putative amino-acid transporter subunit 3351086 yhdZ 8177411 yhdZ Escherichia coli B str. REL606 putative amino-acid transporter subunit YP_003046314.1 3350328 D 413997 CDS YP_003046315.1 254163207 8177419 3357141..3357695 1 NC_012967.1 similar to b3279; hypothetical protein 3357695 yrdA 8177419 yrdA Escherichia coli B str. REL606 hypothetical protein YP_003046315.1 3357141 D 413997 CDS YP_003046316.1 254163208 8177420 complement(3357671..3357928) 1 NC_012967.1 similar to b3280; hypothetical protein 3357928 yrdB 8177420 yrdB Escherichia coli B str. REL606 hypothetical protein YP_003046316.1 3357671 R 413997 CDS YP_003046317.1 254163209 8177421 complement(3357925..3358743) 1 NC_012967.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 3358743 aroE 8177421 aroE Escherichia coli B str. REL606 shikimate 5-dehydrogenase YP_003046317.1 3357925 R 413997 CDS YP_003046318.1 254163210 8177422 complement(3358748..3359320) 1 NC_012967.1 RimN; YrdC; required for maturation of 16s RNA; binds preferentially double stranded RNA; putative ribosome maturation factor 3359320 yrdC 8177422 yrdC Escherichia coli B str. REL606 putative ribosome maturation factor YP_003046318.1 3358748 R 413997 CDS YP_003046319.1 254163211 8177423 complement(3359325..3359867) 1 NC_012967.1 similar to b3283; putative DNA topoisomerase 3359867 yrdD 8177423 yrdD Escherichia coli B str. REL606 putative DNA topoisomerase YP_003046319.1 3359325 R 413997 CDS YP_003046320.1 254163212 8177424 complement(3359896..3360369) 1 NC_012967.1 similar to b3284; hypothetical protein 3360369 smg 8177424 smg Escherichia coli B str. REL606 hypothetical protein YP_003046320.1 3359896 R 413997 CDS YP_003046321.1 254163213 8177425 complement(3360341..3361465) 1 NC_012967.1 similar to b4473; DNA protecting protein DprA 3361465 smf 8177425 smf Escherichia coli B str. REL606 DNA protecting protein DprA YP_003046321.1 3360341 R 413997 CDS YP_003046322.1 254163214 8178707 3361595..3362104 1 NC_012967.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 3362104 def 8178707 def Escherichia coli B str. REL606 peptide deformylase YP_003046322.1 3361595 D 413997 CDS YP_003046323.1 254163215 8177426 3362119..3363066 1 NC_012967.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 3363066 fmt 8177426 fmt Escherichia coli B str. REL606 methionyl-tRNA formyltransferase YP_003046323.1 3362119 D 413997 CDS YP_003046324.1 254163216 8179238 3363112..3364401 1 NC_012967.1 catalyzes the methylation of cytosine at position 967 (m5C967) of 16S rRNA; SAM-dependent methyltransferase; 16S rRNA methyltransferase B 3364401 rrmB 8179238 rrmB Escherichia coli B str. REL606 16S rRNA methyltransferase B YP_003046324.1 3363112 D 413997 CDS YP_003046325.1 254163217 8177427 3364423..3365799 1 NC_012967.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane component 3365799 trkA 8177427 trkA Escherichia coli B str. REL606 potassium transporter peripheral membrane component YP_003046325.1 3364423 D 413997 CDS YP_003046326.1 254163218 8177428 3365929..3366339 1 NC_012967.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel 3366339 mscL 8177428 mscL Escherichia coli B str. REL606 large-conductance mechanosensitive channel YP_003046326.1 3365929 D 413997 CDS YP_003046327.1 254163219 8179239 complement(3366336..3366554) 1 NC_012967.1 similar to b4550; hypothetical protein 3366554 yhdL 8179239 yhdL Escherichia coli B str. REL606 hypothetical protein YP_003046327.1 3366336 R 413997 CDS YP_003046328.1 254163220 8177429 complement(3366610..3367035) 1 NC_012967.1 mediates expression of the zinc export protein ZntA in response to high levels of zinc; member of MerR family of transcriptional regulators; zinc-responsive transcriptional regulator 3367035 zntR 8177429 zntR Escherichia coli B str. REL606 zinc-responsive transcriptional regulator YP_003046328.1 3366610 R 413997 CDS YP_003046329.1 254163221 8177430 complement(3367046..3367414) 1 NC_012967.1 similar to b3293; hypothetical protein 3367414 yhdN 8177430 yhdN Escherichia coli B str. REL606 hypothetical protein YP_003046329.1 3367046 R 413997 CDS YP_003046330.1 254163222 8179240 complement(3367521..3367904) 1 NC_012967.1 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 3367904 rplQ 8179240 rplQ Escherichia coli B str. REL606 50S ribosomal protein L17 YP_003046330.1 3367521 R 413997 CDS YP_003046331.1 254163223 8177431 complement(3367945..3368934) 1 NC_012967.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 3368934 rpoA 8177431 rpoA Escherichia coli B str. REL606 DNA-directed RNA polymerase subunit alpha YP_003046331.1 3367945 R 413997 CDS YP_003046332.1 254163224 8177432 complement(3368960..3369580) 1 NC_012967.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 3369580 rpsD 8177432 rpsD Escherichia coli B str. REL606 30S ribosomal protein S4 YP_003046332.1 3368960 R 413997 CDS YP_003046333.1 254163225 8177433 complement(3369614..3370003) 1 NC_012967.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 3370003 rpsK 8177433 rpsK Escherichia coli B str. REL606 30S ribosomal protein S11 YP_003046333.1 3369614 R 413997 CDS YP_003046334.1 254163226 8179241 complement(3370020..3370376) 1 NC_012967.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 3370376 rpsM 8179241 rpsM Escherichia coli B str. REL606 30S ribosomal protein S13 YP_003046334.1 3370020 R 413997 CDS YP_003046335.1 254163227 8177434 complement(3370523..3370639) 1 NC_012967.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 3370639 rpmJ 8177434 rpmJ Escherichia coli B str. REL606 50S ribosomal protein L36 YP_003046335.1 3370523 R 413997 CDS YP_003046336.1 254163228 8178708 complement(3370671..3372002) 1 NC_012967.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 3372002 secY 8178708 secY Escherichia coli B str. REL606 preprotein translocase subunit SecY YP_003046336.1 3370671 R 413997 CDS YP_003046337.1 254163229 8177435 complement(3372010..3372444) 1 NC_012967.1 late assembly protein; 50S ribosomal protein L15 3372444 rplO 8177435 rplO Escherichia coli B str. REL606 50S ribosomal protein L15 YP_003046337.1 3372010 R 413997 CDS YP_003046338.1 254163230 8179242 complement(3372448..3372627) 1 NC_012967.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 3372627 rpmD 8179242 rpmD Escherichia coli B str. REL606 50S ribosomal protein L30 YP_003046338.1 3372448 R 413997 CDS YP_003046339.1 254163231 8177436 complement(3372631..3373134) 1 NC_012967.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 3373134 rpsE 8177436 rpsE Escherichia coli B str. REL606 30S ribosomal protein S5 YP_003046339.1 3372631 R 413997 CDS YP_003046340.1 254163232 8177437 complement(3373149..3373502) 1 NC_012967.1 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 3373502 rplR 8177437 rplR Escherichia coli B str. REL606 50S ribosomal protein L18 YP_003046340.1 3373149 R 413997 CDS YP_003046341.1 254163233 8179243 complement(3373512..3374045) 1 NC_012967.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 3374045 rplF 8179243 rplF Escherichia coli B str. REL606 50S ribosomal protein L6 YP_003046341.1 3373512 R 413997 CDS YP_003046342.1 254163234 8177438 complement(3374058..3374450) 1 NC_012967.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 3374450 rpsH 8177438 rpsH Escherichia coli B str. REL606 30S ribosomal protein S8 YP_003046342.1 3374058 R 413997 CDS YP_003046343.1 254163235 8177439 complement(3374484..3374789) 1 NC_012967.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 3374789 rpsN 8177439 rpsN Escherichia coli B str. REL606 30S ribosomal protein S14 YP_003046343.1 3374484 R 413997 CDS YP_003046344.1 254163236 8177440 complement(3374804..3375343) 1 NC_012967.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 3375343 rplE 8177440 rplE Escherichia coli B str. REL606 50S ribosomal protein L5 YP_003046344.1 3374804 R 413997 CDS YP_003046345.1 254163237 8177441 complement(3375358..3375672) 1 NC_012967.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 3375672 rplX 8177441 rplX Escherichia coli B str. REL606 50S ribosomal protein L24 YP_003046345.1 3375358 R 413997 CDS YP_003046346.1 254163238 8177442 complement(3375683..3376054) 1 NC_012967.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 3376054 rplN 8177442 rplN Escherichia coli B str. REL606 50S ribosomal protein L14 YP_003046346.1 3375683 R 413997 CDS YP_003046347.1 254163239 8177443 complement(3376219..3376473) 1 NC_012967.1 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 3376473 rpsQ 8177443 rpsQ Escherichia coli B str. REL606 30S ribosomal protein S17 YP_003046347.1 3376219 R 413997 CDS YP_003046348.1 254163240 8177444 complement(3376473..3376664) 1 NC_012967.1 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 3376664 rpmC 8177444 rpmC Escherichia coli B str. REL606 50S ribosomal protein L29 YP_003046348.1 3376473 R 413997 CDS YP_003046349.1 254163241 8177445 complement(3376664..3377074) 1 NC_012967.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 3377074 rplP 8177445 rplP Escherichia coli B str. REL606 50S ribosomal protein L16 YP_003046349.1 3376664 R 413997 CDS YP_003046350.1 254163242 8179244 complement(3377087..3377788) 1 NC_012967.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 3377788 rpsC 8179244 rpsC Escherichia coli B str. REL606 30S ribosomal protein S3 YP_003046350.1 3377087 R 413997 CDS YP_003046351.1 254163243 8177446 complement(3377806..3378138) 1 NC_012967.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 3378138 rplV 8177446 rplV Escherichia coli B str. REL606 50S ribosomal protein L22 YP_003046351.1 3377806 R 413997 CDS YP_003046352.1 254163244 8179245 complement(3378153..3378431) 1 NC_012967.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 3378431 rpsS 8179245 rpsS Escherichia coli B str. REL606 30S ribosomal protein S19 YP_003046352.1 3378153 R 413997 CDS YP_003046353.1 254163245 8177447 complement(3378448..3379269) 1 NC_012967.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 3379269 rplB 8177447 rplB Escherichia coli B str. REL606 50S ribosomal protein L2 YP_003046353.1 3378448 R 413997 CDS YP_003046354.1 254163246 8177448 complement(3379287..3379589) 1 NC_012967.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 3379589 rplW 8177448 rplW Escherichia coli B str. REL606 50S ribosomal protein L23 YP_003046354.1 3379287 R 413997 CDS YP_003046355.1 254163247 8178709 complement(3379586..3380191) 1 NC_012967.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 3380191 rplD 8178709 rplD Escherichia coli B str. REL606 50S ribosomal protein L4 YP_003046355.1 3379586 R 413997 CDS YP_003046356.1 254163248 8177449 complement(3380202..3380831) 1 NC_012967.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 3380831 rplC 8177449 rplC Escherichia coli B str. REL606 50S ribosomal protein L3 YP_003046356.1 3380202 R 413997 CDS YP_003046357.1 254163249 8177450 complement(3380864..3381175) 1 NC_012967.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 3381175 rpsJ 8177450 rpsJ Escherichia coli B str. REL606 30S ribosomal protein S10 YP_003046357.1 3380864 R 413997 CDS YP_003046358.1 254163250 8178710 complement(3381413..3381832) 1 NC_012967.1 calcium-binding protein that may be required for the initiation of chromosome replication; chromosome replication protein PioO 3381832 pioO 8178710 pioO Escherichia coli B str. REL606 chromosome replication protein PioO YP_003046358.1 3381413 R 413997 CDS YP_003046359.1 254163251 8177451 complement(3381834..3383303) 1 NC_012967.1 similar to b3323; general secretory pathway component, cryptic 3383303 gspA 8177451 gspA Escherichia coli B str. REL606 general secretory pathway component, cryptic YP_003046359.1 3381834 R 413997 CDS YP_003046360.1 254163252 8177452 3383483..3384298 1 NC_012967.1 similar to b3324; general secretory pathway component, cryptic 3384298 gspC 8177452 gspC Escherichia coli B str. REL606 general secretory pathway component, cryptic YP_003046360.1 3383483 D 413997 CDS YP_003046361.1 254163253 8177453 3384282..3386234 1 NC_012967.1 similar to b3325; general secretory pathway component, cryptic 3386234 gspD 8177453 gspD Escherichia coli B str. REL606 general secretory pathway component, cryptic YP_003046361.1 3384282 D 413997 CDS YP_003046362.1 254163254 8179246 3386244..3387725 1 NC_012967.1 similar to b3326; general secretory pathway component, cryptic 3387725 gspE 8179246 gspE Escherichia coli B str. REL606 general secretory pathway component, cryptic YP_003046362.1 3386244 D 413997 CDS YP_003046363.1 254163255 8177454 3387722..3388918 1 NC_012967.1 similar to b3327; general secretory pathway component, cryptic 3388918 gspF 8177454 gspF Escherichia coli B str. REL606 general secretory pathway component, cryptic YP_003046363.1 3387722 D 413997 CDS YP_003046364.1 254163256 8177455 3388928..3389365 1 NC_012967.1 similar to b3328; pseudopilin, cryptic, general secretion pathway 3389365 gspG 8177455 gspG Escherichia coli B str. REL606 pseudopilin, cryptic, general secretion pathway YP_003046364.1 3388928 D 413997 CDS YP_003046365.1 254163257 8179247 3389373..3389882 1 NC_012967.1 similar to b3329; putative general secretory pathway component, cryptic 3389882 gspH 8179247 gspH Escherichia coli B str. REL606 putative general secretory pathway component, cryptic YP_003046365.1 3389373 D 413997 CDS YP_003046366.1 254163258 8177456 3389879..3390256 1 NC_012967.1 similar to b3330; general secretory pathway component, cryptic 3390256 gspI 8177456 gspI Escherichia coli B str. REL606 general secretory pathway component, cryptic YP_003046366.1 3389879 D 413997 CDS YP_003046367.1 254163259 8178711 3390249..3390836 1 NC_012967.1 similar to b3331; putative general secretory pathway component, cryptic 3390836 gspJ 8178711 gspJ Escherichia coli B str. REL606 putative general secretory pathway component, cryptic YP_003046367.1 3390249 D 413997 CDS YP_003046368.1 254163260 8177457 3390829..3391812 1 NC_012967.1 similar to b3332; general secretory pathway component, cryptic 3391812 gspK 8177457 gspK Escherichia coli B str. REL606 general secretory pathway component, cryptic YP_003046368.1 3390829 D 413997 CDS YP_003046369.1 254163261 8177458 3391827..3392990 1 NC_012967.1 similar to b3333; general secretory pathway component, cryptic 3392990 gspL 8177458 gspL Escherichia coli B str. REL606 general secretory pathway component, cryptic YP_003046369.1 3391827 D 413997 CDS YP_003046370.1 254163262 8178712 3392987..3393448 1 NC_012967.1 similar to b3334; general secretory pathway component, cryptic 3393448 gspM 8178712 gspM Escherichia coli B str. REL606 general secretory pathway component, cryptic YP_003046370.1 3392987 D 413997 CDS YP_003046371.1 254163263 8177459 3393448..3394125 1 NC_012967.1 similar to b3335; bifunctional prepilin leader peptidase/ methylase 3394125 gspO 8177459 gspO Escherichia coli B str. REL606 bifunctional prepilin leader peptidase/ methylase YP_003046371.1 3393448 D 413997 CDS YP_003046372.1 254163264 8177460 complement(3394154..3394630) 1 NC_012967.1 iron storage protein; bacterioferritin 3394630 bfr 8177460 bfr Escherichia coli B str. REL606 bacterioferritin YP_003046372.1 3394154 R 413997 CDS YP_003046373.1 254163265 8177461 complement(3394702..3394896) 1 NC_012967.1 similar to b3337; bacterioferritin-associated ferredoxin 3394896 bfd 8177461 bfd Escherichia coli B str. REL606 bacterioferritin-associated ferredoxin YP_003046373.1 3394702 R 413997 CDS YP_003046374.1 254163266 8177462 complement(3395065..3397758) 1 NC_012967.1 similar to b3338; periplasmic endochitinase 3397758 chiA 8177462 chiA Escherichia coli B str. REL606 periplasmic endochitinase YP_003046374.1 3395065 R 413997 CDS YP_003046375.1 254163267 8177463 complement(3398050..3399234) 1 NC_012967.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 3399234 tufA 8177463 tufA Escherichia coli B str. REL606 elongation factor Tu YP_003046375.1 3398050 R 413997 CDS YP_003046376.1 254163268 8179248 complement(3399305..3401419) 1 NC_012967.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 3401419 fusA 8179248 fusA Escherichia coli B str. REL606 elongation factor G YP_003046376.1 3399305 R 413997 CDS YP_003046377.1 254163269 8177464 complement(3401516..3401986) 1 NC_012967.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 3401986 rpsG 8177464 rpsG Escherichia coli B str. REL606 30S ribosomal protein S7 YP_003046377.1 3401516 R 413997 CDS YP_003046378.1 254163270 8177465 complement(3402083..3402457) 1 NC_012967.1 similar to b3342; 30S ribosomal protein S12 3402457 rpsL 8177465 rpsL Escherichia coli B str. REL606 30S ribosomal protein S12 YP_003046378.1 3402083 R 413997 CDS YP_003046379.1 254163271 8178713 complement(3402583..3402870) 1 NC_012967.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusB 3402870 yheL 8178713 yheL Escherichia coli B str. REL606 sulfur transfer complex subunit TusB YP_003046379.1 3402583 R 413997 CDS YP_003046380.1 254163272 8177466 complement(3402878..3403237) 1 NC_012967.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur relay protein TusC 3403237 yheM 8177466 yheM Escherichia coli B str. REL606 sulfur relay protein TusC YP_003046380.1 3402878 R 413997 CDS YP_003046381.1 254163273 8177467 complement(3403237..3403623) 1 NC_012967.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusD 3403623 yheN 8177467 yheN Escherichia coli B str. REL606 sulfur transfer complex subunit TusD YP_003046381.1 3403237 R 413997 CDS YP_003046382.1 254163274 8178714 complement(3403623..3404345) 1 NC_012967.1 similar to b3346; putative DNA-binding transcriptional regulator 3404345 yheO 8178714 yheO Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003046382.1 3403623 R 413997 CDS YP_003046383.1 254163275 8177468 complement(3404512..3405324) 1 NC_012967.1 rotamase; FKBP-type peptidyl-prolyl cis-trans isomerase 3405324 fkpA 8177468 fkpA Escherichia coli B str. REL606 FKBP-type peptidyl-prolyl cis-trans isomerase YP_003046383.1 3404512 R 413997 CDS YP_003046384.1 254163276 8177469 3405545..3405763 1 NC_012967.1 similar to b3348; hypothetical protein 3405763 slyX 8177469 slyX Escherichia coli B str. REL606 hypothetical protein YP_003046384.1 3405545 D 413997 CDS YP_003046385.1 254163277 8177470 complement(3405812..3406402) 1 NC_012967.1 rotamase; FKBP-type peptidyl-prolyl cis-trans isomerase 3406402 slyD 8177470 slyD Escherichia coli B str. REL606 FKBP-type peptidyl-prolyl cis-trans isomerase YP_003046385.1 3405812 R 413997 CDS YP_003046386.1 254163278 8179249 complement(3406707..3408512) 1 NC_012967.1 involved in potassium efflux; glutathione-regulated potassium-efflux system protein KefB 3408512 kefB 8179249 kefB Escherichia coli B str. REL606 glutathione-regulated potassium-efflux system protein KefB YP_003046386.1 3406707 R 413997 CDS YP_003046387.1 254163279 8177471 complement(3408512..3409066) 1 NC_012967.1 required for KefB activity; glutathione-regulated potassium-efflux system ancillary protein KefG 3409066 yheR 8177471 yheR Escherichia coli B str. REL606 glutathione-regulated potassium-efflux system ancillary protein KefG YP_003046387.1 3408512 R 413997 CDS YP_003046388.1 254163280 8177472 3409194..3411107 1 NC_012967.1 similar to b3352; putative ABC transporter ATP-binding protein 3411107 yheS 8177472 yheS Escherichia coli B str. REL606 putative ABC transporter ATP-binding protein YP_003046388.1 3409194 D 413997 CDS YP_003046389.1 254163281 8179250 3411107..3412129 1 NC_012967.1 similar to b3353; putative hydrolase 3412129 yheT 8179250 yheT Escherichia coli B str. REL606 putative hydrolase YP_003046389.1 3411107 D 413997 CDS YP_003046390.1 254163282 8177473 3412123..3412341 1 NC_012967.1 similar to b3354; hypothetical protein 3412341 yheU 8177473 yheU Escherichia coli B str. REL606 hypothetical protein YP_003046390.1 3412123 D 413997 CDS YP_003046391.1 254163283 8178715 3412395..3413264 1 NC_012967.1 similar to b3355; putative phosphoribulokinase 3413264 prkB 8178715 prkB Escherichia coli B str. REL606 putative phosphoribulokinase YP_003046391.1 3412395 D 413997 CDS YP_003046392.1 254163284 8177474 complement(3413319..3413723) 1 NC_012967.1 similar to b3356; hypothetical protein 3413723 yhfA 8177474 yhfA Escherichia coli B str. REL606 hypothetical protein YP_003046392.1 3413319 R 413997 CDS YP_003046393.1 254163285 8177475 3414025..3414657 1 NC_012967.1 complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons; cAMP-regulatory protein 3414657 crp 8177475 crp Escherichia coli B str. REL606 cAMP-regulatory protein YP_003046393.1 3414025 D 413997 CDS YP_003046394.1 254163286 8178716 3414696..3416798 1 NC_012967.1 similar to b3358; inner membrane protein 3416798 yhfK 8178716 yhfK Escherichia coli B str. REL606 inner membrane protein YP_003046394.1 3414696 D 413997 CDS YP_003046395.1 254163287 8177476 complement(3416865..3418085) 1 NC_012967.1 DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate; bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein 3418085 argD 8177476 argD Escherichia coli B str. REL606 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein YP_003046395.1 3416865 R 413997 CDS YP_003046396.1 254163288 8177477 complement(3418171..3418734) 1 NC_012967.1 aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; para-aminobenzoate synthase component II 3418734 pabA 8177477 pabA Escherichia coli B str. REL606 para-aminobenzoate synthase component II YP_003046396.1 3418171 R 413997 CDS YP_003046397.1 254163289 8177478 complement(3418766..3419368) 1 NC_012967.1 similar to b3361; cell filamentation protein Fic 3419368 fic 8177478 fic Escherichia coli B str. REL606 cell filamentation protein Fic YP_003046397.1 3418766 R 413997 CDS YP_003046398.1 254163290 8177479 complement(3419358..3419525) 1 NC_012967.1 similar to b3362; hypothetical protein 3419525 yhfG 8177479 yhfG Escherichia coli B str. REL606 hypothetical protein YP_003046398.1 3419358 R 413997 CDS YP_003046399.1 254163291 8177480 complement(3419630..3420202) 1 NC_012967.1 similar to b3363; peptidyl-prolyl cis-trans isomerase A (rotamase A) 3420202 ppiA 8177480 ppiA Escherichia coli B str. REL606 peptidyl-prolyl cis-trans isomerase A (rotamase A) YP_003046399.1 3419630 R 413997 CDS YP_003046400.1 254163292 8177481 3420473..3421654 1 NC_012967.1 similar to b3364; hypothetical protein 3421654 yhfC 8177481 yhfC Escherichia coli B str. REL606 hypothetical protein YP_003046400.1 3420473 D 413997 CDS YP_003046401.1 254163293 8179251 3421916..3424459 1 NC_012967.1 similar to b3365; nitrite reductase, large subunit, NAD(P)H-binding 3424459 nirB 8179251 nirB Escherichia coli B str. REL606 nitrite reductase, large subunit, NAD(P)H-binding YP_003046401.1 3421916 D 413997 CDS YP_003046402.1 254163294 8177482 3424456..3424782 1 NC_012967.1 involved in reducing nitrite to ammonium to detoxify nitrite accumulation in anaerobic nitrate-respiring cells and regenerate NAD+; bounds to NirB, the cytoplasmic subunit, whose expression is induced at high nitrate concentrations; nitrite reductase small subunit 3424782 nirD 8177482 nirD Escherichia coli B str. REL606 nitrite reductase small subunit YP_003046402.1 3424456 D 413997 CDS YP_003046403.1 254163295 8177483 3424908..3425714 1 NC_012967.1 member of the FNT family of formate and nitrite transporters; nitrite transporter NirC 3425714 nirC 8177483 nirC Escherichia coli B str. REL606 nitrite transporter NirC YP_003046403.1 3424908 D 413997 CDS YP_003046404.1 254163296 8179252 3425733..3427106 1 NC_012967.1 multifunction enzyme consisting of uroporphyrin-III C-methyltransferase, precorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase; catalyzes the methylation of uroporphyrinogen III to form precorrin-2, then catalyzes formation of sirohydrochlorin from precorrin-2 and finally catalyzed the formation of siroheme from sirohydrochlorin; siroheme synthase 3427106 cysG 8179252 cysG Escherichia coli B str. REL606 siroheme synthase YP_003046404.1 3425733 D 413997 CDS YP_003046405.1 254163297 8177484 3427353..3427520 1 NC_012967.1 similar to b3369; secreted peptide 3427520 yhfL 8177484 yhfL Escherichia coli B str. REL606 secreted peptide YP_003046405.1 3427353 D 413997 CDS YP_003046406.1 254163298 8177485 3427815..3429152 1 NC_012967.1 inner membrane protein possibly involved in fructoselysine transport; member of the flr operon; putative fructoselysine transporter 3429152 frlA 8177485 frlA Escherichia coli B str. REL606 putative fructoselysine transporter YP_003046406.1 3427815 D 413997 CDS YP_003046407.1 254163299 8177486 3429173..3430195 1 NC_012967.1 catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine; fructoselysine-6-P-deglycase 3430195 frlB 8177486 frlB Escherichia coli B str. REL606 fructoselysine-6-P-deglycase YP_003046407.1 3429173 D 413997 CDS YP_003046408.1 254163300 8177487 3430245..3431075 1 NC_012967.1 YhfOP; YhfP; YhfO; FrlC; catalyzes the interconversion of fructoselysine and psicoselysine; fructoselysine 3-epimerase 3431075 frlC 8177487 frlC Escherichia coli B str. REL606 fructoselysine 3-epimerase YP_003046408.1 3430245 D 413997 CDS YP_003046409.1 254163301 8177488 3431072..3431857 1 NC_012967.1 similar to b3374; fructoselysine 6-kinase 3431857 yhfQ 8177488 yhfQ Escherichia coli B str. REL606 fructoselysine 6-kinase YP_003046409.1 3431072 D 413997 CDS YP_003046410.1 254163302 8177489 3431957..3432688 1 NC_012967.1 may act as a transcriptional regulator of a putative fructoselysine-induced operon containing the yhfM, yhfN, yhfO, yhfP, yhfQ, and yhfR genes; DNA-binding transcriptional regulator FrlR 3432688 yhfR 8177489 yhfR Escherichia coli B str. REL606 DNA-binding transcriptional regulator FrlR YP_003046410.1 3431957 D 413997 CDS YP_003046411.1 254163303 8177491 complement(3433477..3433980) 1 NC_012967.1 IS1 protein InsB 3433980 insB-23 8177491 insB-23 Escherichia coli B str. REL606 IS1 protein InsB YP_003046411.1 3433477 R 413997 CDS YP_003046412.1 254163304 8179253 complement(3433899..3434174) 1 NC_012967.1 IS1 protein InsA 3434174 insA-23 8179253 insA-23 Escherichia coli B str. REL606 IS1 protein InsA YP_003046412.1 3433899 R 413997 CDS YP_003046413.1 254163305 8177492 complement(3434714..3436018) 1 NC_012967.1 similar to b3377; putative inner membrane protein 3436018 yhfT 8177492 yhfT Escherichia coli B str. REL606 putative inner membrane protein YP_003046413.1 3434714 R 413997 CDS YP_003046414.1 254163306 8178717 complement(3436030..3436383) 1 NC_012967.1 similar to b3378; hypothetical protein 3436383 yhfU 8178717 yhfU Escherichia coli B str. REL606 hypothetical protein YP_003046414.1 3436030 R 413997 CDS YP_003046415.1 254163307 8177493 complement(3436394..3437272) 1 NC_012967.1 phosphotriesterase homology protein; PhP; YhfV; member of a family of proteins related to phosphotriesterase (PTE); putative hydrolase 3437272 yhfV 8177493 yhfV Escherichia coli B str. REL606 putative hydrolase YP_003046415.1 3436394 R 413997 CDS YP_003046416.1 254163308 8177494 complement(3437269..3438495) 1 NC_012967.1 similar to b3380; putative mutase 3438495 yhfW 8177494 yhfW Escherichia coli B str. REL606 putative mutase YP_003046416.1 3437269 R 413997 CDS YP_003046417.1 254163309 8177495 complement(3438495..3439658) 1 NC_012967.1 similar to b3381; putative amino acid racemase 3439658 yhfX 8177495 yhfX Escherichia coli B str. REL606 putative amino acid racemase YP_003046417.1 3438495 R 413997 CDS YP_003046418.1 254163310 8177496 complement(3439742..3440104) 1 NC_012967.1 similar to b3382; hypothetical protein 3440104 yhfY 8177496 yhfY Escherichia coli B str. REL606 hypothetical protein YP_003046418.1 3439742 R 413997 CDS YP_003046419.1 254163311 8177497 complement(3440121..3441026) 1 NC_012967.1 similar to b3383; hypothetical protein 3441026 yhfZ 8177497 yhfZ Escherichia coli B str. REL606 hypothetical protein YP_003046419.1 3440121 R 413997 CDS YP_003046420.1 254163312 8177498 complement(3441316..3442320) 1 NC_012967.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 3442320 trpS 8177498 trpS Escherichia coli B str. REL606 tryptophanyl-tRNA synthetase YP_003046420.1 3441316 R 413997 CDS YP_003046421.1 254163313 8177499 complement(3442313..3443071) 1 NC_012967.1 catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate; phosphoglycolate phosphatase 3443071 gph 8177499 gph Escherichia coli B str. REL606 phosphoglycolate phosphatase YP_003046421.1 3442313 R 413997 CDS YP_003046422.1 254163314 8177500 complement(3443064..3443741) 1 NC_012967.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase 3443741 rpe 8177500 rpe Escherichia coli B str. REL606 ribulose-phosphate 3-epimerase YP_003046422.1 3443064 R 413997 CDS YP_003046423.1 254163315 8179254 complement(3443759..3444595) 1 NC_012967.1 similar to b3387; DNA adenine methylase 3444595 dam 8179254 dam Escherichia coli B str. REL606 DNA adenine methylase YP_003046423.1 3443759 R 413997 CDS YP_003046424.1 254163316 8177501 complement(3444702..3445988) 1 NC_012967.1 similar to b3388; hypothetical protein 3445988 damX 8177501 damX Escherichia coli B str. REL606 hypothetical protein YP_003046424.1 3444702 R 413997 CDS YP_003046425.1 254163317 8177502 complement(3446080..3447168) 1 NC_012967.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 3447168 aroB 8177502 aroB Escherichia coli B str. REL606 3-dehydroquinate synthase YP_003046425.1 3446080 R 413997 CDS YP_003046426.1 254163318 8177503 complement(3447225..3447746) 1 NC_012967.1 type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase I 3447746 aroK 8177503 aroK Escherichia coli B str. REL606 shikimate kinase I YP_003046426.1 3447225 R 413997 CDS YP_003046427.1 254163319 8179255 complement(3448147..3449385) 1 NC_012967.1 outer membrane porin probably involved in uptake of extracellular double-stranded DNA; similar to outer membrane competence protein ComE from Haemophilus influenzae and outer membrane protein PilQ involved in type IV pilus production from Pseudomonas aeruginosa; outer membrane porin HofQ 3449385 hofQ 8179255 hofQ Escherichia coli B str. REL606 outer membrane porin HofQ YP_003046427.1 3448147 R 413997 CDS YP_003046428.1 254163320 8177504 complement(3449297..3449701) 1 NC_012967.1 similar to b3392; hypothetical protein 3449701 yrfA 8177504 yrfA Escherichia coli B str. REL606 hypothetical protein YP_003046428.1 3449297 R 413997 CDS YP_003046429.1 254163321 8177505 complement(3449691..3450131) 1 NC_012967.1 similar to b3393; hypothetical protein 3450131 yrfB 8177505 yrfB Escherichia coli B str. REL606 hypothetical protein YP_003046429.1 3449691 R 413997 CDS YP_003046430.1 254163322 8177506 complement(3450115..3450654) 1 NC_012967.1 similar to b3394; putative fimbrial assembly protein 3450654 yrfC 8177506 yrfC Escherichia coli B str. REL606 putative fimbrial assembly protein YP_003046430.1 3450115 R 413997 CDS YP_003046431.1 254163323 8177507 complement(3450654..3451433) 1 NC_012967.1 similar to b3395; putative pilus assembly protein 3451433 yrfD 8177507 yrfD Escherichia coli B str. REL606 putative pilus assembly protein YP_003046431.1 3450654 R 413997 CDS YP_003046432.1 254163324 8177508 3451553..3454105 1 NC_012967.1 bifunctional murein transglycosylase/murein transpeptidase; penicillin-binding protein 1A; involved in the synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation; penicillin-insensitive transglycosylase catalyzes the formation of linear glycan strands and the penicillin-sensitive transpeptidase catalyzes the cross-linking of the peptide subunits; peptidoglycan synthetase 3454105 mrcA 8177508 mrcA Escherichia coli B str. REL606 peptidoglycan synthetase YP_003046432.1 3451553 D 413997 CDS YP_003046433.1 254163325 8177509 complement(3454273..3454833) 1 NC_012967.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose diphosphatase NudE 3454833 nudE 8177509 nudE Escherichia coli B str. REL606 ADP-ribose diphosphatase NudE YP_003046433.1 3454273 R 413997 CDS YP_003046434.1 254163326 8177510 3455153..3457288 1 NC_012967.1 similar to b3398; putative inner membrane protein 3457288 yrfF 8177510 yrfF Escherichia coli B str. REL606 putative inner membrane protein YP_003046434.1 3455153 D 413997 CDS YP_003046435.1 254163327 8178718 3457353..3458021 1 NC_012967.1 similar to b3399; putative hydrolase 3458021 yrfG 8178718 yrfG Escherichia coli B str. REL606 putative hydrolase YP_003046435.1 3457353 D 413997 CDS YP_003046436.1 254163328 8177511 3458032..3458433 1 NC_012967.1 similar to b3400; ribosome-associated heat shock protein Hsp15 3458433 hslR 8177511 hslR Escherichia coli B str. REL606 ribosome-associated heat shock protein Hsp15 YP_003046436.1 3458032 D 413997 CDS YP_003046437.1 254163329 8178719 3458458..3459336 1 NC_012967.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 3459336 hslO 8178719 hslO Escherichia coli B str. REL606 Hsp33-like chaperonin YP_003046437.1 3458458 D 413997 CDS YP_003046438.1 254163330 8178720 complement(3459399..3461123) 1 NC_012967.1 similar to b3402; putative inner membrane protein 3461123 yhgE 8178720 yhgE Escherichia coli B str. REL606 putative inner membrane protein YP_003046438.1 3459399 R 413997 CDS YP_003046439.1 254163331 8177512 3461502..3463124 1 NC_012967.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase 3463124 pckA 8177512 pckA Escherichia coli B str. REL606 phosphoenolpyruvate carboxykinase YP_003046439.1 3461502 D 413997 CDS YP_003046440.1 254163332 8179256 complement(3463200..3464552) 1 NC_012967.1 membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR; osmolarity sensor protein 3464552 envZ 8179256 envZ Escherichia coli B str. REL606 osmolarity sensor protein YP_003046440.1 3463200 R 413997 CDS YP_003046441.1 254163333 8177513 complement(3464549..3465268) 1 NC_012967.1 part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation; osmolarity response regulator 3465268 ompR 8177513 ompR Escherichia coli B str. REL606 osmolarity response regulator YP_003046441.1 3464549 R 413997 CDS YP_003046442.1 254163334 8177514 3465496..3465972 1 NC_012967.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreB 3465972 greB 8177514 greB Escherichia coli B str. REL606 transcription elongation factor GreB YP_003046442.1 3465496 D 413997 CDS YP_003046443.1 254163335 8177515 3466072..3468390 1 NC_012967.1 similar to b3407; putative transcriptional accessory protein 3468390 yhgF 8177515 yhgF Escherichia coli B str. REL606 putative transcriptional accessory protein YP_003046443.1 3466072 D 413997 CDS YP_003046444.1 254163336 8177516 3468828..3469055 1 NC_012967.1 similar to b3408; ferrous iron transport protein A 3469055 feoA 8177516 feoA Escherichia coli B str. REL606 ferrous iron transport protein A YP_003046444.1 3468828 D 413997 CDS YP_003046445.1 254163337 8177517 3469072..3471393 1 NC_012967.1 cytoplasmic membrane ferrous uptake system permease; mutations disrupt the ability of Escherichia coli to take up ferrous iron; GTP-binding protein which requires GTP for efficient iron(II) uptake; ferrous iron transport protein B 3471393 feoB 8177517 feoB Escherichia coli B str. REL606 ferrous iron transport protein B YP_003046445.1 3469072 D 413997 CDS YP_003046446.1 254163338 8177518 3471393..3471629 1 NC_012967.1 similar to b3410; putative DNA-binding transcriptional regulator 3471629 yhgG 8177518 yhgG Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003046446.1 3471393 D 413997 CDS YP_003046447.1 254163339 8179257 3471832..3472710 1 NC_012967.1 similar to b3411; hypothetical protein 3472710 yhgA 8179257 yhgA Escherichia coli B str. REL606 hypothetical protein YP_003046447.1 3471832 D 413997 CDS YP_003046448.1 254163340 8177519 complement(3472739..3473509) 1 NC_012967.1 Shows carboxylesterase activity with a preference for short chain fatty acid esters; involved in pimeloyl-CoA synthesis; carboxylesterase BioH 3473509 bioH 8177519 bioH Escherichia coli B str. REL606 carboxylesterase BioH YP_003046448.1 3472739 R 413997 CDS YP_003046449.1 254163341 8177520 3473547..3474230 1 NC_012967.1 involved in high-affinity gluconate transport; gluconate periplasmic binding protein 3474230 yhgH 8177520 yhgH Escherichia coli B str. REL606 gluconate periplasmic binding protein YP_003046449.1 3473547 D 413997 CDS YP_003046450.1 254163342 8179258 3474289..3474864 1 NC_012967.1 cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source; putative DNA uptake protein 3474864 yhgI 8179258 yhgI Escherichia coli B str. REL606 putative DNA uptake protein YP_003046450.1 3474289 D 413997 CDS YP_003046451.1 254163343 8177521 3475225..3476541 1 NC_012967.1 similar to b3415; gluconate transporter, high-affinity GNT I system 3476541 gntT 8177521 gntT Escherichia coli B str. REL606 gluconate transporter, high-affinity GNT I system YP_003046451.1 3475225 D 413997 CDS YP_003046452.1 254163344 8177522 complement(3476586..3478670) 1 NC_012967.1 amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase 3478670 malQ 8177522 malQ Escherichia coli B str. REL606 4-alpha-glucanotransferase YP_003046452.1 3476586 R 413997 CDS YP_003046453.1 254163345 8177523 complement(3478680..3481073) 1 NC_012967.1 similar to b3417; maltodextrin phosphorylase 3481073 malP 8177523 malP Escherichia coli B str. REL606 maltodextrin phosphorylase YP_003046453.1 3478680 R 413997 CDS YP_003046454.1 254163346 8177524 3481685..3484390 1 NC_012967.1 Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides; transcriptional regulator MalT 3484390 malT 8177524 malT Escherichia coli B str. REL606 transcriptional regulator MalT YP_003046454.1 3481685 D 413997 CDS YP_003046455.1 254163347 8177525 complement(3484433..3485449) 1 NC_012967.1 catalyzes the conversion of terminal3'-phosphate of RNA to the 2',3'-cyclicphosphodiester; RNA 3'-terminal-phosphate cyclase 3485449 rtcA 8177525 rtcA Escherichia coli B str. REL606 RNA 3'-terminal-phosphate cyclase YP_003046455.1 3484433 R 413997 CDS YP_003046456.1 254163348 8177526 complement(3485453..3486679) 1 NC_012967.1 similar to b3421; hypothetical protein 3486679 rtcB 8177526 rtcB Escherichia coli B str. REL606 hypothetical protein YP_003046456.1 3485453 R 413997 CDS YP_003046457.1 254163349 8177527 3486868..3488466 1 NC_012967.1 similar to b3422; sigma 54-dependent transcriptional regulator of rtcBA expression 3488466 rtcR 8177527 rtcR Escherichia coli B str. REL606 sigma 54-dependent transcriptional regulator of rtcBA expression YP_003046457.1 3486868 D 413997 CDS YP_003046458.1 254163350 8177528 complement(3488448..3489206) 1 NC_012967.1 represses the glpD, glpFK, glpTQ, and glpACB operons involved in glycerol-3-phosphate metabolism; DNA-binding transcriptional repressor GlpR 3489206 glpR 8177528 glpR Escherichia coli B str. REL606 DNA-binding transcriptional repressor GlpR YP_003046458.1 3488448 R 413997 CDS YP_003046459.1 254163351 8178721 complement(3489223..3490053) 1 NC_012967.1 protease responsible for the cleavage between Ser and Asp residues of proteins in regions of high local hydrophilicity; intramembrane serine protease GlpG 3490053 glpG 8178721 glpG Escherichia coli B str. REL606 intramembrane serine protease GlpG YP_003046459.1 3489223 R 413997 CDS YP_003046460.1 254163352 8177529 complement(3490098..3490424) 1 NC_012967.1 belongs to rhodanese family; thiosulfate thiotransferase; in Escherichia coli this enzyme catalyzes the formation of thiocyanate from thiosulfate and cyanide with low efficiency; contains an active site cysteine; thiosulfate sulfurtransferase 3490424 glpE 8177529 glpE Escherichia coli B str. REL606 thiosulfate sulfurtransferase YP_003046460.1 3490098 R 413997 CDS YP_003046461.1 254163353 8179259 3490614..3492119 1 NC_012967.1 in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane; glycerol-3-phosphate dehydrogenase 3492119 glpD 8179259 glpD Escherichia coli B str. REL606 glycerol-3-phosphate dehydrogenase YP_003046461.1 3490614 D 413997 CDS YP_003046462.1 254163354 8177530 complement(3492937..3493929) 1 NC_012967.1 hypothetical protein 3493929 8177530 ECB_03279 Escherichia coli B str. REL606 hypothetical protein YP_003046462.1 3492937 R 413997 CDS YP_003046463.1 254163355 8179260 complement(3495588..3498035) 1 NC_012967.1 similar to b3428; glycogen phosphorylase 3498035 glgP 8179260 glgP Escherichia coli B str. REL606 glycogen phosphorylase YP_003046463.1 3495588 R 413997 CDS YP_003046464.1 254163356 8177531 complement(3498054..3499487) 1 NC_012967.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 3499487 glgA 8177531 glgA Escherichia coli B str. REL606 glycogen synthase YP_003046464.1 3498054 R 413997 CDS YP_003046465.1 254163357 8177532 complement(3499487..3500803) 1 NC_012967.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 3500803 glgC 8177532 glgC Escherichia coli B str. REL606 glucose-1-phosphate adenylyltransferase YP_003046465.1 3499487 R 413997 CDS YP_003046466.1 254163358 8177533 complement(3500800..3502773) 1 NC_012967.1 catalyzes the hydrolysis of the alpha-1,6-glucosidic linkages in partially depolymerized glycogen; glycogen debranching enzyme 3502773 glgX 8177533 glgX Escherichia coli B str. REL606 glycogen debranching enzyme YP_003046466.1 3500800 R 413997 CDS YP_003046467.1 254163359 8177534 complement(3502770..3504956) 1 NC_012967.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching enzyme 3504956 glgB 8177534 glgB Escherichia coli B str. REL606 glycogen branching enzyme YP_003046467.1 3502770 R 413997 CDS YP_003046468.1 254163360 8177535 complement(3505229..3506332) 1 NC_012967.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 3506332 asd 8177535 asd Escherichia coli B str. REL606 aspartate-semialdehyde dehydrogenase YP_003046468.1 3505229 R 413997 CDS YP_003046469.1 254163361 8177536 3506524..3507117 1 NC_012967.1 YhgN; Ec0197; hydrolyzes nucleoside triphosphates with an O6 atom-containing purine base to nucleoside monophosphate and pyrophosphate; seems to play a role in the elimination of aberrant purine-derived nucleotides containing the 6-keto group; shows preference for deoxyinosine triphosphate and xanthosine triphosphate over standard nucleoside triphosphates (dATP, dCTP, dGTP, and dTTP); putative dITP- and XTP- hydrolase 3507117 yhgN 8177536 yhgN Escherichia coli B str. REL606 putative dITP- and XTP- hydrolase YP_003046469.1 3506524 D 413997 CDS YP_003046470.1 254163362 8179261 complement(3507174..3508514) 1 NC_012967.1 similar to b4476; low affinity gluconate transporter 3508514 gntU 8179261 gntU Escherichia coli B str. REL606 low affinity gluconate transporter YP_003046470.1 3507174 R 413997 CDS YP_003046471.1 254163363 8177537 complement(3508518..3509045) 1 NC_012967.1 thermoresistant; catalyzes the formation of 6-phospho-D-gluconate from gluconate; gluconate kinase 1 3509045 gntK 8177537 gntK Escherichia coli B str. REL606 gluconate kinase 1 YP_003046471.1 3508518 R 413997 CDS YP_003046472.1 254163364 8177538 complement(3509184..3510179) 1 NC_012967.1 similar to b3438; DNA-binding transcriptional repressor 3510179 gntR 8177538 gntR Escherichia coli B str. REL606 DNA-binding transcriptional repressor YP_003046472.1 3509184 R 413997 CDS YP_003046473.1 254163365 8177539 complement(3510403..3511098) 1 NC_012967.1 similar to b3439; hypothetical protein 3511098 yhhW 8177539 yhhW Escherichia coli B str. REL606 hypothetical protein YP_003046473.1 3510403 R 413997 CDS YP_003046474.1 254163366 8177540 complement(3511221..3512258) 1 NC_012967.1 similar to b3440; putative dehydrogenase 3512258 yhhX 8177540 yhhX Escherichia coli B str. REL606 putative dehydrogenase YP_003046474.1 3511221 R 413997 CDS YP_003046475.1 254163367 8177541 3512591..3513079 1 NC_012967.1 YhhY; regulated by the fur regulator; unknown function; putative acetyltransferase YhhY 3513079 yhhY 8177541 yhhY Escherichia coli B str. REL606 putative acetyltransferase YhhY YP_003046475.1 3512591 D 413997 CDS YP_003046476.1 254163368 8177542 3513316..3514494 1 NC_012967.1 similar to b3442; hypothetical protein 3514494 yhhZ 8177542 yhhZ Escherichia coli B str. REL606 hypothetical protein YP_003046476.1 3513316 D 413997 CDS YP_003046477.1 254163369 8177543 3514494..3514985 1 NC_012967.1 similar to b3443; hypothetical protein 3514985 yrhA 8177543 yrhA Escherichia coli B str. REL606 hypothetical protein YP_003046477.1 3514494 D 413997 CDS YP_003046478.1 254163370 8178723 3515435..3515719 1 NC_012967.1 similar to b3446; hypothetical protein 3515719 yrhB 8178723 yrhB Escherichia coli B str. REL606 hypothetical protein YP_003046478.1 3515435 D 413997 CDS YP_003046479.1 254163371 8177544 complement(3515757..3517499) 1 NC_012967.1 periplasmic enzyme; post-translationally processed into two subunits which are required for wild-type enzyme activity; cleaves the gammaglutamyl linkages of compounds such as glutathione and transfer the gammaglutamyl group to other amino acids and peptides; gamma-glutamyltranspeptidase 3517499 ggt 8177544 ggt Escherichia coli B str. REL606 gamma-glutamyltranspeptidase YP_003046479.1 3515757 R 413997 CDS YP_003046480.1 254163372 8178724 3517619..3518059 1 NC_012967.1 similar to b3448; hypothetical protein 3518059 yhhA 8178724 yhhA Escherichia coli B str. REL606 hypothetical protein YP_003046480.1 3517619 D 413997 CDS YP_003046481.1 254163373 8178725 complement(3518046..3518789) 1 NC_012967.1 hydrolyzes diesters during transport at the inner face of the cytoplasmic membrane to glycerol-3-phosphate and alcohol; induced when cells are starved for inorganic phosphate; cytoplasmic glycerophosphodiester phosphodiesterase 3518789 ugpQ 8178725 ugpQ Escherichia coli B str. REL606 cytoplasmic glycerophosphodiester phosphodiesterase YP_003046481.1 3518046 R 413997 CDS YP_003046482.1 254163374 8177545 complement(3518786..3519856) 1 NC_012967.1 part of the UgpABCE glycerol-3-phosphate uptake system; glycerol-3-phosphate transporter ATP-binding subunit 3519856 ugpC 8177545 ugpC Escherichia coli B str. REL606 glycerol-3-phosphate transporter ATP-binding subunit YP_003046482.1 3518786 R 413997 CDS YP_003046483.1 254163375 8179262 complement(3519858..3520703) 1 NC_012967.1 with UgpABC is involved in uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter membrane protein 3520703 ugpE 8179262 ugpE Escherichia coli B str. REL606 glycerol-3-phosphate transporter membrane protein YP_003046483.1 3519858 R 413997 CDS YP_003046484.1 254163376 8177546 complement(3520700..3521587) 1 NC_012967.1 with UgpEC is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter permease 3521587 ugpA 8177546 ugpA Escherichia coli B str. REL606 glycerol-3-phosphate transporter permease YP_003046484.1 3520700 R 413997 CDS YP_003046485.1 254163377 8177547 complement(3521685..3523001) 1 NC_012967.1 with UgpACE is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter periplasmic binding protein 3523001 ugpB 8177547 ugpB Escherichia coli B str. REL606 glycerol-3-phosphate transporter periplasmic binding protein YP_003046485.1 3521685 R 413997 CDS YP_003046486.1 254163378 8177548 complement(3523398..3524111) 1 NC_012967.1 with LivGHMJ and LivGHMK is part of the high-affinity branched-chain amino acid transport system; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding subunit 3524111 livF 8177548 livF Escherichia coli B str. REL606 leucine/isoleucine/valine transporter ATP-binding subunit YP_003046486.1 3523398 R 413997 CDS YP_003046487.1 254163379 8179263 complement(3524113..3524880) 1 NC_012967.1 Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding subunit 3524880 livG 8179263 livG Escherichia coli B str. REL606 leucine/isoleucine/valine transporter ATP-binding subunit YP_003046487.1 3524113 R 413997 CDS YP_003046488.1 254163380 8177549 complement(3524877..3526154) 1 NC_012967.1 Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter permease 3526154 livM 8177549 livM Escherichia coli B str. REL606 leucine/isoleucine/valine transporter permease YP_003046488.1 3524877 R 413997 CDS YP_003046489.1 254163381 8177550 complement(3526151..3527077) 1 NC_012967.1 LivHMGF is the membrane component of the LIV-I/LS branched-chain amino acid transporter; branched-chain amino acid transporter permease LivH 3527077 livH 8177550 livH Escherichia coli B str. REL606 branched-chain amino acid transporter permease LivH YP_003046489.1 3526151 R 413997 CDS YP_003046490.1 254163382 8177551 complement(3527125..3528234) 1 NC_012967.1 similar to b3458; leucine transporter subunit 3528234 livK 8177551 livK Escherichia coli B str. REL606 leucine transporter subunit YP_003046490.1 3527125 R 413997 CDS YP_003046491.1 254163383 8177552 3528658..3529041 1 NC_012967.1 similar to b3459; hypothetical protein 3529041 yhhK 8177552 yhhK Escherichia coli B str. REL606 hypothetical protein YP_003046491.1 3528658 D 413997 CDS YP_003046492.1 254163384 8177553 complement(3529240..3530343) 1 NC_012967.1 similar to b3460; leucine/isoleucine/valine transporter subunit 3530343 livJ 8177553 livJ Escherichia coli B str. REL606 leucine/isoleucine/valine transporter subunit YP_003046492.1 3529240 R 413997 CDS YP_003046493.1 254163385 8177554 complement(3530614..3531468) 1 NC_012967.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 3531468 rpoH 8177554 rpoH Escherichia coli B str. REL606 RNA polymerase factor sigma-32 YP_003046493.1 3530614 R 413997 CDS YP_003046494.1 254163386 8179264 complement(3531713..3532771) 1 NC_012967.1 putative ABC transporter, membrane protein; cell division protein FtsX 3532771 ftsX 8179264 ftsX Escherichia coli B str. REL606 cell division protein FtsX YP_003046494.1 3531713 R 413997 CDS YP_003046495.1 254163387 8177555 complement(3532764..3533432) 1 NC_012967.1 putative ATP-binding protein of an ATP-binding cassette transporter; when bound to FtsX, FtsEX localizes to the cell division site and plays a role in the assembly or stability of the septal ring under low-salt growth conditions; cell division protein FtsE 3533432 ftsE 8177555 ftsE Escherichia coli B str. REL606 cell division protein FtsE YP_003046495.1 3532764 R 413997 CDS YP_003046496.1 254163388 8179265 complement(3533435..3534931) 1 NC_012967.1 signal recognition protein receptor; functions in the targeting and insertion of membrane proteins; cell division protein FtsY 3534931 ftsY 8179265 ftsY Escherichia coli B str. REL606 cell division protein FtsY YP_003046496.1 3533435 R 413997 CDS YP_003046497.1 254163389 8177556 3535081..3535677 1 NC_012967.1 catalyzes the methylation of 16S rRNA at position G966; 16S rRNA m(2)G966-methyltransferase 3535677 rsmD 8177556 rsmD Escherichia coli B str. REL606 16S rRNA m(2)G966-methyltransferase YP_003046497.1 3535081 D 413997 CDS YP_003046498.1 254163390 8177557 3535667..3535936 1 NC_012967.1 similar to b3466; hypothetical protein 3535936 yhhL 8177557 yhhL Escherichia coli B str. REL606 hypothetical protein YP_003046498.1 3535667 D 413997 CDS YP_003046499.1 254163391 8177558 complement(3535939..3536298) 1 NC_012967.1 similar to b3467; hypothetical protein 3536298 yhhM 8177558 yhhM Escherichia coli B str. REL606 hypothetical protein YP_003046499.1 3535939 R 413997 CDS YP_003046500.1 254163392 8178726 3536439..3537065 1 NC_012967.1 similar to b3468; inner membrane protein 3537065 yhhN 8178726 yhhN Escherichia coli B str. REL606 inner membrane protein YP_003046500.1 3536439 D 413997 CDS YP_003046501.1 254163393 8177559 3537139..3539337 1 NC_012967.1 P-type ATPase involved in the export of lead, cadmium, zinc and mercury; zinc/cadmium/mercury/lead-transporting ATPase 3539337 zntA 8177559 zntA Escherichia coli B str. REL606 zinc/cadmium/mercury/lead-transporting ATPase YP_003046501.1 3537139 D 413997 CDS YP_003046502.1 254163394 8177560 complement(3539439..3539684) 1 NC_012967.1 TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein SirA 3539684 sirA 8177560 sirA Escherichia coli B str. REL606 sulfur transfer protein SirA YP_003046502.1 3539439 R 413997 CDS YP_003046503.1 254163395 8177561 3539905..3540570 1 NC_012967.1 similar to b3471; hypothetical protein 3540570 yhhQ 8177561 yhhQ Escherichia coli B str. REL606 hypothetical protein YP_003046503.1 3539905 D 413997 CDS YP_003046504.1 254163396 8177562 3540643..3541200 1 NC_012967.1 similar to b3472; hypothetical protein 3541200 dcrB 8177562 dcrB Escherichia coli B str. REL606 hypothetical protein YP_003046504.1 3540643 D 413997 CDS YP_003046505.1 254163397 8178727 complement(3541204..3542421) 1 NC_012967.1 similar to b3473; major facilitator superfamily transporter 3542421 yhhS 8178727 yhhS Escherichia coli B str. REL606 major facilitator superfamily transporter YP_003046505.1 3541204 R 413997 CDS YP_003046506.1 254163398 8177563 3542553..3543602 1 NC_012967.1 similar to b3474; putative inner membrane protein 3543602 yhhT 8177563 yhhT Escherichia coli B str. REL606 putative inner membrane protein YP_003046506.1 3542553 D 413997 CDS YP_003046507.1 254163399 8178728 3543657..3544244 1 NC_012967.1 similar to b3475; holo-(acyl carrier protein) synthase 2 3544244 acpT 8178728 acpT Escherichia coli B str. REL606 holo-(acyl carrier protein) synthase 2 YP_003046507.1 3543657 D 413997 CDS YP_003046508.1 254163400 8177564 3544355..3545929 1 NC_012967.1 similar to b3476; nickel transporter subunit 3545929 nikA 8177564 nikA Escherichia coli B str. REL606 nickel transporter subunit YP_003046508.1 3544355 D 413997 CDS YP_003046509.1 254163401 8177565 3545929..3546873 1 NC_012967.1 with NikACDE is involved in nickel transport into the cell; nickel transporter permease NikB 3546873 nikB 8177565 nikB Escherichia coli B str. REL606 nickel transporter permease NikB YP_003046509.1 3545929 D 413997 CDS YP_003046510.1 254163402 8178729 3546870..3547703 1 NC_012967.1 with NikABDE is involved in nickel transport into the cell; nickel transporter permease NikC 3547703 nikC 8178729 nikC Escherichia coli B str. REL606 nickel transporter permease NikC YP_003046510.1 3546870 D 413997 CDS YP_003046511.1 254163403 8177566 3547703..3548467 1 NC_012967.1 with NikABCE is involved in nickel transport into the cell; nickel transporter ATP-binding protein NikD 3548467 nikD 8177566 nikD Escherichia coli B str. REL606 nickel transporter ATP-binding protein NikD YP_003046511.1 3547703 D 413997 CDS YP_003046512.1 254163404 8177567 3548464..3549270 1 NC_012967.1 with NikABCD is involved with nickel transport into the cell; nickel transporter ATP-binding protein NikE 3549270 nikE 8177567 nikE Escherichia coli B str. REL606 nickel transporter ATP-binding protein NikE YP_003046512.1 3548464 D 413997 CDS YP_003046513.1 254163405 8177568 3549276..3549677 1 NC_012967.1 Inhibits transcription at high concentrations of nickel; nickel responsive regulator 3549677 nikR 8177568 nikR Escherichia coli B str. REL606 nickel responsive regulator YP_003046513.1 3549276 D 413997 CDS YP_003046514.1 254163406 8177569 3549880..3554115 1 NC_012967.1 similar to b3482; rhsB element core protein RshB 3554115 rhsB 8177569 rhsB Escherichia coli B str. REL606 rhsB element core protein RshB YP_003046514.1 3549880 D 413997 CDS YP_003046515.1 254163407 8177570 3554087..3554470 1 NC_012967.1 similar to b3483; hypothetical protein 3554470 yhhH 8177570 yhhH Escherichia coli B str. REL606 hypothetical protein YP_003046515.1 3554087 D 413997 CDS YP_003046516.1 254163408 8177571 3555066..3556202 1 NC_012967.1 similar to b3484; putative transposase 3556202 yhhI 8177571 yhhI Escherichia coli B str. REL606 putative transposase YP_003046516.1 3555066 D 413997 CDS YP_003046517.1 254163409 8177572 complement(3556367..3557491) 1 NC_012967.1 similar to b3485; putative transporter subunit membrane component of ABC superfamily 3557491 yhhJ 8177572 yhhJ Escherichia coli B str. REL606 putative transporter subunit membrane component of ABC superfamily YP_003046517.1 3556367 R 413997 CDS YP_003046518.1 254163410 8177573 complement(3557491..3560226) 1 NC_012967.1 similar to b3486; ribosome-associated ATPase 3560226 yhiH 8177573 yhiH Escherichia coli B str. REL606 ribosome-associated ATPase YP_003046518.1 3557491 R 413997 CDS YP_003046519.1 254163411 8177574 complement(3560223..3561290) 1 NC_012967.1 similar to b3487; putative HlyD family secretion protein 3561290 yhiI 8177574 yhiI Escherichia coli B str. REL606 putative HlyD family secretion protein YP_003046519.1 3560223 R 413997 CDS YP_003046520.1 254163412 8178730 complement(3561656..3563278) 1 NC_012967.1 similar to b3488; hypothetical protein 3563278 yhiJ 8178730 yhiJ Escherichia coli B str. REL606 hypothetical protein YP_003046520.1 3561656 R 413997 CDS YP_003046521.1 254163413 8177575 complement(3563540..3565147) 1 NC_012967.1 similar to b3489-b3490; hypothetical protein 3565147 yhiKL 8177575 yhiKL Escherichia coli B str. REL606 hypothetical protein YP_003046521.1 3563540 R 413997 CDS YP_003046522.1 254163414 8177576 3565530..3566582 1 NC_012967.1 similar to b3491; inner membrane protein 3566582 yhiM 8177576 yhiM Escherichia coli B str. REL606 inner membrane protein YP_003046522.1 3565530 D 413997 CDS YP_003046523.1 254163415 8177577 complement(3566897..3568099) 1 NC_012967.1 similar to b3492; putative oxidoreductase with FAD/NAD(P)-binding domain 3568099 yhiN 8177577 yhiN Escherichia coli B str. REL606 putative oxidoreductase with FAD/NAD(P)-binding domain YP_003046523.1 3566897 R 413997 CDS YP_003046524.1 254163416 8178731 3568331..3569830 1 NC_012967.1 similar to b3493; phosphate transporter, low-affinity 3569830 pitA 8178731 pitA Escherichia coli B str. REL606 phosphate transporter, low-affinity YP_003046524.1 3568331 D 413997 CDS YP_003046525.1 254163417 8177578 complement(3570074..3570409) 1 NC_012967.1 ppGpp-dependent, membrane associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress; universal stress protein UspB 3570409 yhiO 8177578 yhiO Escherichia coli B str. REL606 universal stress protein UspB YP_003046525.1 3570074 R 413997 CDS YP_003046526.1 254163418 8178732 3570800..3571234 1 NC_012967.1 similar to b3495; universal stress global response regulator 3571234 uspA 8178732 uspA Escherichia coli B str. REL606 universal stress global response regulator YP_003046526.1 3570800 D 413997 CDS YP_003046527.1 254163419 8177579 3571552..3573021 1 NC_012967.1 member of the POT family of peptide transporters; probable proton-dependent peptide transporter function; inner membrane transporter YhiP 3573021 yhiP 8177579 yhiP Escherichia coli B str. REL606 inner membrane transporter YhiP YP_003046527.1 3571552 D 413997 CDS YP_003046528.1 254163420 8177580 complement(3573070..3573822) 1 NC_012967.1 predicted SAM-dependent methyltransferase; putative methyltransferase 3573822 yhiQ 8177580 yhiQ Escherichia coli B str. REL606 putative methyltransferase YP_003046528.1 3573070 R 413997 CDS YP_003046529.1 254163421 8178733 complement(3573830..3575872) 1 NC_012967.1 similar to b3498; oligopeptidase A 3575872 prlC 8178733 prlC Escherichia coli B str. REL606 oligopeptidase A YP_003046529.1 3573830 R 413997 CDS YP_003046530.1 254163422 8179267 3576075..3576917 1 NC_012967.1 similar to b3499; putative DNA (exogenous) processing protein 3576917 yhiR 8179267 yhiR Escherichia coli B str. REL606 putative DNA (exogenous) processing protein YP_003046530.1 3576075 D 413997 CDS YP_003046531.1 254163423 8177581 3576989..3578341 1 NC_012967.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 3578341 gor 8177581 gor Escherichia coli B str. REL606 glutathione reductase YP_003046531.1 3576989 D 413997 CDS YP_003046532.1 254163424 8177582 3579218..3579571 1 NC_012967.1 regulates the expression of of the arsRBC involved in resistance to arsenic; DNA-binding transcriptional repressor ArsR 3579571 arsR 8177582 arsR Escherichia coli B str. REL606 DNA-binding transcriptional repressor ArsR YP_003046532.1 3579218 D 413997 CDS YP_003046533.1 254163425 8177583 3579625..3580914 1 NC_012967.1 similar to b3502; arsenite/antimonite transporter 3580914 arsB 8177583 arsB Escherichia coli B str. REL606 arsenite/antimonite transporter YP_003046533.1 3579625 D 413997 CDS YP_003046534.1 254163426 8177584 3580927..3581352 1 NC_012967.1 similar to b3503; arsenate reductase 3581352 arsC 8177584 arsC Escherichia coli B str. REL606 arsenate reductase YP_003046534.1 3580927 D 413997 CDS YP_003046535.1 254163427 8179268 3581981..3583204 1 NC_012967.1 similar to b3504; hypothetical protein 3583204 yhiS 8179268 yhiS Escherichia coli B str. REL606 hypothetical protein YP_003046535.1 3581981 D 413997 CDS YP_003046536.1 254163428 8177585 3583452..3584018 1 NC_012967.1 similar to b3506; outer membrane lipoprotein 3584018 slp 8177585 slp Escherichia coli B str. REL606 outer membrane lipoprotein YP_003046536.1 3583452 D 413997 CDS YP_003046537.1 254163429 8177586 3584174..3584704 1 NC_012967.1 similar to b3507; putative DNA-binding ranscriptional regulator 3584704 yhiF 8177586 yhiF Escherichia coli B str. REL606 putative DNA-binding ranscriptional regulator YP_003046537.1 3584174 D 413997 CDS YP_003046538.1 254163430 8179269 complement(3584746..3585393) 1 NC_012967.1 inner membrane protein involved in cell density-dependent acid resistance; part of the acid fitness island (AFI) of E. coli; putative Mg(2+) transport ATPase 3585393 yhiD 8179269 yhiD Escherichia coli B str. REL606 putative Mg(2+) transport ATPase YP_003046538.1 3584746 R 413997 CDS YP_003046539.1 254163431 8177587 complement(3585457..3585783) 1 NC_012967.1 similar to b3509; acid-resistance protein 3585783 hdeB 8177587 hdeB Escherichia coli B str. REL606 acid-resistance protein YP_003046539.1 3585457 R 413997 CDS YP_003046540.1 254163432 8177588 complement(3585899..3586231) 1 NC_012967.1 inactive form; acid-resistance protein 3586231 hdeA 8177588 hdeA Escherichia coli B str. REL606 acid-resistance protein YP_003046540.1 3585899 R 413997 CDS YP_003046541.1 254163433 8179270 3586486..3587058 1 NC_012967.1 similar to b3511; acid-resistance membrane protein 3587058 hdeD 8179270 hdeD Escherichia coli B str. REL606 acid-resistance membrane protein YP_003046541.1 3586486 D 413997 CDS YP_003046542.1 254163434 8177589 3587857..3588384 1 NC_012967.1 similar to b3512; DNA-binding transcriptional activator 3588384 yhiE 8177589 yhiE Escherichia coli B str. REL606 DNA-binding transcriptional activator YP_003046542.1 3587857 D 413997 CDS YP_003046543.1 254163435 8179271 3588723..3589880 1 NC_012967.1 with MdtF and tolC is involved in resistance to rhodamine 6G, erythromycin, doxorubicin and other compounds; multidrug efflux system protein MdtE 3589880 yhiU 8179271 yhiU Escherichia coli B str. REL606 multidrug efflux system protein MdtE YP_003046543.1 3588723 D 413997 CDS YP_003046544.1 254163436 8177590 3589905..3593018 1 NC_012967.1 similar to b3514; multidrug transporter, RpoS-dependent 3593018 yhiV 8177590 yhiV Escherichia coli B str. REL606 multidrug transporter, RpoS-dependent YP_003046544.1 3589905 D 413997 CDS YP_003046545.1 254163437 8177591 complement(3593381..3594109) 1 NC_012967.1 similar to b3515; DNA-binding transcriptional activator 3594109 yhiW 8177591 yhiW Escherichia coli B str. REL606 DNA-binding transcriptional activator YP_003046545.1 3593381 R 413997 CDS YP_003046546.1 254163438 8177592 complement(3594477..3595301) 1 NC_012967.1 regulates genes in response to acid and/or during stationary phase; DNA-binding transcriptional regulator GadX 3595301 gadX 8177592 gadX Escherichia coli B str. REL606 DNA-binding transcriptional regulator GadX YP_003046546.1 3594477 R 413997 CDS YP_003046547.1 254163439 8177593 complement(3595671..3597071) 1 NC_012967.1 similar to b3517; glutamate decarboxylase A, PLP-dependent 3597071 gadA 8177593 gadA Escherichia coli B str. REL606 glutamate decarboxylase A, PLP-dependent YP_003046547.1 3595671 R 413997 CDS YP_003046548.1 254163440 8177594 complement(3597282..3598679) 1 NC_012967.1 similar to b3518; putative cytochrome C peroxidase 3598679 yhjA 8177594 yhjA Escherichia coli B str. REL606 putative cytochrome C peroxidase YP_003046548.1 3597282 R 413997 CDS YP_003046549.1 254163441 8178734 3599084..3600733 1 NC_012967.1 cytoplasmic; catalyzes the hydrolysis of trehalose to glucose; trehalase 3600733 treF 8178734 treF Escherichia coli B str. REL606 trehalase YP_003046549.1 3599084 D 413997 CDS YP_003046550.1 254163442 8177595 complement(3600784..3601386) 1 NC_012967.1 similar to b3520; putative DNA-binding response regulator in two-component regulatory system 3601386 yhjB 8177595 yhjB Escherichia coli B str. REL606 putative DNA-binding response regulator in two-component regulatory system YP_003046550.1 3600784 R 413997 CDS YP_003046551.1 254163443 8177596 3601834..3602805 1 NC_012967.1 similar to b3521; putative DNA-binding transcriptional regulator 3602805 yhjC 8177596 yhjC Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003046551.1 3601834 D 413997 CDS YP_003046552.1 254163444 8177597 3602854..3603867 1 NC_012967.1 similar to b3522; inner membrane protein 3603867 yhjD 8177597 yhjD Escherichia coli B str. REL606 inner membrane protein YP_003046552.1 3602854 D 413997 CDS YP_003046553.1 254163445 8177598 3604278..3605600 1 NC_012967.1 similar to b3523; putative transporter 3605600 yhjE 8177598 yhjE Escherichia coli B str. REL606 putative transporter YP_003046553.1 3604278 D 413997 CDS YP_003046554.1 254163446 8177599 complement(3605782..3607857) 1 NC_012967.1 similar to b3524; putative outer membrane biogenesis protein 3607857 yhjG 8177599 yhjG Escherichia coli B str. REL606 putative outer membrane biogenesis protein YP_003046554.1 3605782 R 413997 CDS YP_003046555.1 254163447 8177600 complement(3607912..3608679) 1 NC_012967.1 in Escherichia coli this protein is involved in flagellar function; EAL domain-containing protein 3608679 yhjH 8177600 yhjH Escherichia coli B str. REL606 EAL domain-containing protein YP_003046555.1 3607912 R 413997 CDS YP_003046556.1 254163448 8177601 3608911..3609840 1 NC_012967.1 similar to b3526; ketodeoxygluconokinase 3609840 kdgK 8177601 kdgK Escherichia coli B str. REL606 ketodeoxygluconokinase YP_003046556.1 3608911 D 413997 CDS YP_003046557.1 254163449 8177602 complement(3609936..3611432) 1 NC_012967.1 similar to b3527; putative zinc-dependent peptidase 3611432 yhjJ 8177602 yhjJ Escherichia coli B str. REL606 putative zinc-dependent peptidase YP_003046557.1 3609936 R 413997 CDS YP_003046558.1 254163450 8179272 complement(3611653..3612939) 1 NC_012967.1 involved in the transport of C4-dicarboxylates across the membrane; C4-dicarboxylate transporter DctA 3612939 dctA 8179272 dctA Escherichia coli B str. REL606 C4-dicarboxylate transporter DctA YP_003046558.1 3611653 R 413997 CDS YP_003046559.1 254163451 8177603 complement(3613122..3615071) 1 NC_012967.1 HmsP in Yersinia pestis plays a role in invasion of epithelial cells; the EAL-domain portion of HmsP from Y. pestis shows phosphodiesterase activity which is required for the inhibition of biofilm formation; inner membrane protein; similar to a putative phosphodiesterase protein from E. coli; putative phosphodiesterase 3615071 yhjK 8177603 yhjK Escherichia coli B str. REL606 putative phosphodiesterase YP_003046559.1 3613122 R 413997 CDS YP_003046560.1 254163452 8177604 complement(3615192..3618665) 1 NC_012967.1 cellulose is produced by the multicellular morphotypes of E. coli and Salmonella typhimurium; the cellulose biosynthesis genes bcsA, bcsB, bcsZ and bcsC are constitutively transcribed, however, cellulose synthesis is dependent on the expression of adrA; cellulose synthase subunit BcsC 3618665 bcsC 8177604 bcsC Escherichia coli B str. REL606 cellulose synthase subunit BcsC YP_003046560.1 3615192 R 413997 CDS YP_003046561.1 254163453 8179273 complement(3618647..3619753) 1 NC_012967.1 catalyzes the hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; endo-1,4-D-glucanase 3619753 bcsZ 8179273 bcsZ Escherichia coli B str. REL606 endo-1,4-D-glucanase YP_003046561.1 3618647 R 413997 CDS YP_003046562.1 254163454 8177605 complement(3619760..3622099) 1 NC_012967.1 binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP); cellulose synthase regulator protein 3622099 yhjN 8177605 yhjN Escherichia coli B str. REL606 cellulose synthase regulator protein YP_003046562.1 3619760 R 413997 CDS YP_003046563.1 254163455 8177606 complement(3622110..3624728) 1 NC_012967.1 polymerizes uridine 5'-diphosphate glucose to cellulose; acts with BcsB, BcsZ and BcsC in cellulose biosynthesis; cellulose synthase catalytic subunit 3624728 bcsA 8177606 bcsA Escherichia coli B str. REL606 cellulose synthase catalytic subunit YP_003046563.1 3622110 R 413997 CDS YP_003046564.1 254163456 8177607 complement(3625489..3625677) 1 NC_012967.1 similar to b3535; hypothetical protein 3625677 yhjR 8177607 yhjR Escherichia coli B str. REL606 hypothetical protein YP_003046564.1 3625489 R 413997 CDS YP_003046565.1 254163457 8177608 3625950..3627521 1 NC_012967.1 similar to b3536; hypothetical protein 3627521 yhjS 8177608 yhjS Escherichia coli B str. REL606 hypothetical protein YP_003046565.1 3625950 D 413997 CDS YP_003046566.1 254163458 8177609 3627521..3627709 1 NC_012967.1 similar to b3537; hypothetical protein 3627709 yhjT 8177609 yhjT Escherichia coli B str. REL606 hypothetical protein YP_003046566.1 3627521 D 413997 CDS YP_003046567.1 254163459 8177610 3627706..3629385 1 NC_012967.1 similar to b3538; putative inner membrane protein 3629385 yhjU 8177610 yhjU Escherichia coli B str. REL606 putative inner membrane protein YP_003046567.1 3627706 D 413997 CDS YP_003046568.1 254163460 8178736 complement(3629472..3629579) 1 NC_012967.1 similar to b4453; toxic polypeptide, small 3629579 ldrD 8178736 ldrD Escherichia coli B str. REL606 toxic polypeptide, small YP_003046568.1 3629472 R 413997 CDS YP_003046569.1 254163461 8177611 complement(3629955..3630062) 1 NC_012967.1 similar to b4453; toxic polypeptide, small 3630062 ldrE 8177611 ldrE Escherichia coli B str. REL606 toxic polypeptide, small YP_003046569.1 3629955 R 413997 CDS YP_003046570.1 254163462 8177612 complement(3630438..3630545) 1 NC_012967.1 similar to b4453; toxic polypeptide, small 3630545 ldrF 8177612 ldrF Escherichia coli B str. REL606 toxic polypeptide, small YP_003046570.1 3630438 R 413997 CDS YP_003046571.1 254163463 8177613 3631021..3632292 1 NC_012967.1 similar to b3539; putative transporter 3632292 yhjV 8177613 yhjV Escherichia coli B str. REL606 putative transporter YP_003046571.1 3631021 D 413997 CDS YP_003046572.1 254163464 8177614 complement(3632322..3633326) 1 NC_012967.1 Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides; dipeptide transporter ATP-binding subunit 3633326 dppF 8177614 dppF Escherichia coli B str. REL606 dipeptide transporter ATP-binding subunit YP_003046572.1 3632322 R 413997 CDS YP_003046573.1 254163465 8179274 complement(3633323..3634306) 1 NC_012967.1 DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF; dipeptide transporter ATP-binding subunit 3634306 dppD 8179274 dppD Escherichia coli B str. REL606 dipeptide transporter ATP-binding subunit YP_003046573.1 3633323 R 413997 CDS YP_003046574.1 254163466 8177615 complement(3634317..3635219) 1 NC_012967.1 similar to b3542; dipeptide transporter 3635219 dppC 8177615 dppC Escherichia coli B str. REL606 dipeptide transporter YP_003046574.1 3634317 R 413997 CDS YP_003046575.1 254163467 8178737 complement(3635229..3636248) 1 NC_012967.1 transports peptides consisting of two or three amino acids; dipeptide transporter permease DppB 3636248 dppB 8178737 dppB Escherichia coli B str. REL606 dipeptide transporter permease DppB YP_003046575.1 3635229 R 413997 CDS YP_003046576.1 254163468 8177616 complement(3636556..3638163) 1 NC_012967.1 similar to b3544; dipeptide transporter 3638163 dppA 8177616 dppA Escherichia coli B str. REL606 dipeptide transporter YP_003046576.1 3636556 R 413997 CDS YP_003046577.1 254163469 8177617 complement(3639242..3640933) 1 NC_012967.1 catalyzes the addition of a phosphoethanolamine group to the outer Kdo residue of lipopolysaccharide; phosphoethanolamine transferase 3640933 yhjW 8177617 yhjW Escherichia coli B str. REL606 phosphoethanolamine transferase YP_003046577.1 3639242 R 413997 CDS YP_003046578.1 254163470 8177618 complement(3641257..3642465) 1 NC_012967.1 similar to b3547; putative transporter 3642465 yhjX 8177618 yhjX Escherichia coli B str. REL606 putative transporter YP_003046578.1 3641257 R 413997 CDS YP_003046579.1 254163471 8178739 complement(3642694..3643392) 1 NC_012967.1 similar to b3548; hypothetical protein 3643392 yhjY 8178739 yhjY Escherichia coli B str. REL606 hypothetical protein YP_003046579.1 3642694 R 413997 CDS YP_003046580.1 254163472 8178740 3643550..3644113 1 NC_012967.1 constitutive, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine; 3-methyl-adenine DNA glycosylase I 3644113 tag 8178740 tag Escherichia coli B str. REL606 3-methyl-adenine DNA glycosylase I YP_003046580.1 3643550 D 413997 CDS YP_003046581.1 254163473 8177619 3644110..3644550 1 NC_012967.1 similar to b3550; hypothetical protein 3644550 yiaC 8177619 yiaC Escherichia coli B str. REL606 hypothetical protein YP_003046581.1 3644110 D 413997 CDS YP_003046582.1 254163474 8177620 complement(3644519..3646798) 1 NC_012967.1 similar to b3551; biotin sulfoxide reductase 3646798 bisC 8177620 bisC Escherichia coli B str. REL606 biotin sulfoxide reductase YP_003046582.1 3644519 R 413997 CDS YP_003046583.1 254163475 8178741 3647005..3647664 1 NC_012967.1 similar to b3552; putative outer membrane lipoprotein 3647664 yiaD 8178741 yiaD Escherichia coli B str. REL606 putative outer membrane lipoprotein YP_003046583.1 3647005 D 413997 CDS YP_003046584.1 254163476 8177621 3647768..3648742 1 NC_012967.1 similar to b3553; 2-ketoaldonate reductase/glyoxylate reductase B 3648742 tkrA 8177621 tkrA Escherichia coli B str. REL606 2-ketoaldonate reductase/glyoxylate reductase B YP_003046584.1 3647768 D 413997 CDS YP_003046585.1 254163477 8178742 complement(3648792..3649502) 1 NC_012967.1 similar to b3554; hypothetical protein 3649502 yiaF 8178742 yiaF Escherichia coli B str. REL606 hypothetical protein YP_003046585.1 3648792 R 413997 CDS YP_003046586.1 254163478 8177622 3649936..3650226 1 NC_012967.1 similar to b3555; putative transcriptional regulator 3650226 yiaG 8177622 yiaG Escherichia coli B str. REL606 putative transcriptional regulator YP_003046586.1 3649936 D 413997 CDS YP_003046587.1 254163479 8177623 3650507..3650719 1 NC_012967.1 similar to b3556; major cold shock protein 3650719 cspA 8177623 cspA Escherichia coli B str. REL606 major cold shock protein YP_003046587.1 3650507 D 413997 CDS YP_003046588.1 254163480 8177624 complement(3650906..3651058) 1 NC_012967.1 similar to b4455; small toxic polypeptide 3651058 hokA 8177624 hokA Escherichia coli B str. REL606 small toxic polypeptide YP_003046588.1 3650906 R 413997 CDS YP_003046589.1 254163481 8177625 3651138..3651659 1 NC_012967.1 IS150 transposase A 3651659 insJ-4 8177625 insJ-4 Escherichia coli B str. REL606 IS150 transposase A YP_003046589.1 3651138 D 413997 CDS YP_003046590.1 254163482 8177626 3651656..3652507 1 NC_012967.1 IS150 putative transposase 3652507 insK-4 8177626 insK-4 Escherichia coli B str. REL606 IS150 putative transposase YP_003046590.1 3651656 D 413997 CDS YP_003046591.1 254163483 8179275 complement(3652786..3654855) 1 NC_012967.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta 3654855 glyS 8179275 glyS Escherichia coli B str. REL606 glycyl-tRNA synthetase subunit beta YP_003046591.1 3652786 R 413997 CDS YP_003046592.1 254163484 8177627 complement(3654865..3655776) 1 NC_012967.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 3655776 glyQ 8177627 glyQ Escherichia coli B str. REL606 glycyl-tRNA synthetase subunit alpha YP_003046592.1 3654865 R 413997 CDS YP_003046593.1 254163485 8177628 complement(3655871..3656170) 1 NC_012967.1 similar to b4553; hypothetical protein 3656170 8177628 ECB_03412 Escherichia coli B str. REL606 hypothetical protein YP_003046593.1 3655871 R 413997 CDS YP_003046594.1 254163486 8177629 3656345..3657340 1 NC_012967.1 similar to b3561; inner membrane protein 3657340 yiaH 8177629 yiaH Escherichia coli B str. REL606 inner membrane protein YP_003046594.1 3656345 D 413997 CDS YP_003046595.1 254163487 8177630 complement(3657382..3657819) 1 NC_012967.1 similar to b3562; hypothetical protein 3657819 yiaA 8177630 yiaA Escherichia coli B str. REL606 hypothetical protein YP_003046595.1 3657382 R 413997 CDS YP_003046596.1 254163488 8177631 complement(3657865..3658206) 1 NC_012967.1 similar to b3563; hypothetical protein 3658206 yiaB 8177631 yiaB Escherichia coli B str. REL606 hypothetical protein YP_003046596.1 3657865 R 413997 CDS YP_003046597.1 254163489 8178743 complement(3658375..3659829) 1 NC_012967.1 similar to b3564; xylulokinase 3659829 xylB 8178743 xylB Escherichia coli B str. REL606 xylulokinase YP_003046597.1 3658375 R 413997 CDS YP_003046598.1 254163490 8177632 complement(3659901..3661223) 1 NC_012967.1 catalyzes the interconversion of D-xylose to D-xylulose; xylose isomerase 3661223 xylA 8177632 xylA Escherichia coli B str. REL606 xylose isomerase YP_003046598.1 3659901 R 413997 CDS YP_003046599.1 254163491 8177633 3661589..3662581 1 NC_012967.1 periplasmic substrate-binding component of the ATP-dependent xylose transport system; high affinity; D-xylose transporter subunit XylF 3662581 xylF 8177633 xylF Escherichia coli B str. REL606 D-xylose transporter subunit XylF YP_003046599.1 3661589 D 413997 CDS YP_003046600.1 254163492 8177635 3664176..3665357 1 NC_012967.1 similar to b3568; D-xylose transporter subunit 3665357 xylH 8177635 xylH Escherichia coli B str. REL606 D-xylose transporter subunit YP_003046600.1 3664176 D 413997 CDS YP_003046601.1 254163493 8178744 3665435..3666613 1 NC_012967.1 similar to b3569; DNA-binding transcriptional activator, xylose-binding 3666613 xylR 8178744 xylR Escherichia coli B str. REL606 DNA-binding transcriptional activator, xylose-binding YP_003046601.1 3665435 D 413997 CDS YP_003046602.1 254163494 8177636 complement(3666809..3667633) 1 NC_012967.1 similar to b3570; hypothetical protein 3667633 bax 8177636 bax Escherichia coli B str. REL606 hypothetical protein YP_003046602.1 3666809 R 413997 CDS YP_003046603.1 254163495 8177637 3667953..3669983 1 NC_012967.1 periplasmic enzyme that degrades maltodextrins that enter via the outer membrane porin LamB; hydrolyzes alpha-(1,4) glycosidic linkages; contains internal disulfide bonds; periplasmic alpha-amylase precursor 3669983 malS 8177637 malS Escherichia coli B str. REL606 periplasmic alpha-amylase precursor YP_003046603.1 3667953 D 413997 CDS YP_003046604.1 254163496 8177638 3670161..3671414 1 NC_012967.1 transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis; valine--pyruvate transaminase 3671414 avtA 8177638 avtA Escherichia coli B str. REL606 valine--pyruvate transaminase YP_003046604.1 3670161 D 413997 CDS YP_003046605.1 254163497 8177639 complement(3671565..3672038) 1 NC_012967.1 similar to b3573; putative hydrogenase, 4Fe-4S ferredoxin-type component 3672038 yiaI 8177639 yiaI Escherichia coli B str. REL606 putative hydrogenase, 4Fe-4S ferredoxin-type component YP_003046605.1 3671565 R 413997 CDS YP_003046606.1 254163498 8179276 complement(3672140..3672988) 1 NC_012967.1 similar to b3574; putative DNA-binding transcriptional repressor 3672988 yiaJ 8179276 yiaJ Escherichia coli B str. REL606 putative DNA-binding transcriptional repressor YP_003046606.1 3672140 R 413997 CDS YP_003046607.1 254163499 8177640 3673189..3674187 1 NC_012967.1 NAD(P)H-dependent; catalyzes the reduction of 2,3-diketo-L-gulonate to 3-keto-L-gulonate; 2,3-diketo-L-gulonate reductase 3674187 yiaK 8177640 yiaK Escherichia coli B str. REL606 2,3-diketo-L-gulonate reductase YP_003046607.1 3673189 D 413997 CDS YP_003046608.1 254163500 8177641 3674199..3674666 1 NC_012967.1 similar to b3576; hypothetical protein 3674666 yiaL 8177641 yiaL Escherichia coli B str. REL606 hypothetical protein YP_003046608.1 3674199 D 413997 CDS YP_003046609.1 254163501 8179277 3674784..3675257 1 NC_012967.1 membrane-spanning protein involved in uptake of 2,3-diketo-L-gulonate; part of the tri-partite ATP-independent periplasmic transport system (TRAP) YiaMNO; 2,3-diketo-L-gulonate TRAP transporter small permease YiaM 3675257 yiaM 8179277 yiaM Escherichia coli B str. REL606 2,3-diketo-L-gulonate TRAP transporter small permease YiaM YP_003046609.1 3674784 D 413997 CDS YP_003046610.1 254163502 8177642 3675260..3676537 1 NC_012967.1 similar to b3578; putative transporter 3676537 yiaN 8177642 yiaN Escherichia coli B str. REL606 putative transporter YP_003046610.1 3675260 D 413997 CDS YP_003046611.1 254163503 8179278 3676550..3677536 1 NC_012967.1 similar to b3579; putative transporter 3677536 yiaO 8179278 yiaO Escherichia coli B str. REL606 putative transporter YP_003046611.1 3676550 D 413997 CDS YP_003046612.1 254163504 8177643 3677540..3679036 1 NC_012967.1 similar to b3580; L-xylulose kinase 3679036 lyxK 8177643 lyxK Escherichia coli B str. REL606 L-xylulose kinase YP_003046612.1 3677540 D 413997 CDS YP_003046613.1 254163505 8177644 3679033..3679695 1 NC_012967.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate; 3-keto-L-gulonate-6-phosphate decarboxylase 3679695 sgbH 8177644 sgbH Escherichia coli B str. REL606 3-keto-L-gulonate-6-phosphate decarboxylase YP_003046613.1 3679033 D 413997 CDS YP_003046614.1 254163506 8177645 3679688..3680548 1 NC_012967.1 L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate; putative L-xylulose 5-phosphate 3-epimerase 3680548 sgbU 8177645 sgbU Escherichia coli B str. REL606 putative L-xylulose 5-phosphate 3-epimerase YP_003046614.1 3679688 D 413997 CDS YP_003046615.1 254163507 8177646 3680542..3681237 1 NC_012967.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 3681237 sgbE 8177646 sgbE Escherichia coli B str. REL606 L-ribulose-5-phosphate 4-epimerase YP_003046615.1 3680542 D 413997 CDS YP_003046616.1 254163508 8178745 complement(3681269..3682084) 1 NC_012967.1 putative regulatory protein 3682084 8178745 ECB_03436 Escherichia coli B str. REL606 putative regulatory protein YP_003046616.1 3681269 R 413997 CDS YP_003046617.1 254163509 8177647 3682310..3683710 1 NC_012967.1 putative permease 3683710 8177647 ECB_03437 Escherichia coli B str. REL606 putative permease YP_003046617.1 3682310 D 413997 CDS YP_003046618.1 254163510 8178746 3683721..3685700 1 NC_012967.1 hypothetical protein 3685700 8178746 ECB_03438 Escherichia coli B str. REL606 hypothetical protein YP_003046618.1 3683721 D 413997 CDS YP_003046619.1 254163511 8177648 complement(3685821..3686561) 1 NC_012967.1 similar to b3584; hypothetical protein 3686561 yiaT 8177648 yiaT Escherichia coli B str. REL606 hypothetical protein YP_003046619.1 3685821 R 413997 CDS YP_003046620.1 254163512 8177649 3686685..3687659 1 NC_012967.1 similar to b3585; putative DNA-binding transcriptional regulator 3687659 yiaU 8177649 yiaU Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003046620.1 3686685 D 413997 CDS YP_003046621.1 254163513 8178747 complement(3687656..3688792) 1 NC_012967.1 similar to b3586; membrane fusion protein (MFP) component of efflux pump, signal anchor 3688792 yiaV 8178747 yiaV Escherichia coli B str. REL606 membrane fusion protein (MFP) component of efflux pump, signal anchor YP_003046621.1 3687656 R 413997 CDS YP_003046622.1 254163514 8177650 complement(3688798..3689121) 1 NC_012967.1 similar to b3587; inner membrane protein 3689121 yiaW 8177650 yiaW Escherichia coli B str. REL606 inner membrane protein YP_003046622.1 3688798 R 413997 CDS YP_003046623.1 254163515 8177651 complement(3689666..3691204) 1 NC_012967.1 similar to b3588; aldehyde dehydrogenase B 3691204 aldB 8177651 aldB Escherichia coli B str. REL606 aldehyde dehydrogenase B YP_003046623.1 3689666 R 413997 CDS YP_003046624.1 254163516 8177652 complement(3691369..3692520) 1 NC_012967.1 similar to b3589; putative alcohol dehydrogenase 3692520 yiaY 8177652 yiaY Escherichia coli B str. REL606 putative alcohol dehydrogenase YP_003046624.1 3691369 R 413997 CDS YP_003046625.1 254163517 8177653 complement(3692710..3694554) 1 NC_012967.1 similar to b3590; selenocysteinyl-tRNA-specific translation factor 3694554 selB 8177653 selB Escherichia coli B str. REL606 selenocysteinyl-tRNA-specific translation factor YP_003046625.1 3692710 R 413997 CDS YP_003046626.1 254163518 8179279 complement(3694551..3695942) 1 NC_012967.1 catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis; selenocysteine synthase 3695942 selA 8179279 selA Escherichia coli B str. REL606 selenocysteine synthase YP_003046626.1 3694551 R 413997 CDS YP_003046627.1 254163519 8177654 complement(3696040..3696648) 1 NC_012967.1 similar to b3592; putative glutathione S-transferase 3696648 yibF 8177654 yibF Escherichia coli B str. REL606 putative glutathione S-transferase YP_003046627.1 3696040 R 413997 CDS YP_003046628.1 254163520 8177655 3696877..3701010 1 NC_012967.1 similar to b3593; rhsA element core protein RshA 3701010 rhsA 8177655 rhsA Escherichia coli B str. REL606 rhsA element core protein RshA YP_003046628.1 3696877 D 413997 CDS YP_003046629.1 254163521 8177656 3701031..3701873 1 NC_012967.1 similar to b3594; hypothetical protein 3701873 yibA 8177656 yibA Escherichia coli B str. REL606 hypothetical protein YP_003046629.1 3701031 D 413997 CDS YP_003046630.1 254163522 8177657 3701915..3702859 1 NC_012967.1 similar to b3595; putative Rhs-family protein 3702859 yibJ 8177657 yibJ Escherichia coli B str. REL606 putative Rhs-family protein YP_003046630.1 3701915 D 413997 CDS YP_003046631.1 254163523 8179280 3702871..3703332 1 NC_012967.1 similar to b3596; hypothetical protein 3703332 yibG 8179280 yibG Escherichia coli B str. REL606 hypothetical protein YP_003046631.1 3702871 D 413997 CDS YP_003046632.1 254163524 8177658 complement(3704936..3706072) 1 NC_012967.1 similar to b3597; hypothetical protein 3706072 yibH 8177658 yibH Escherichia coli B str. REL606 hypothetical protein YP_003046632.1 3704936 R 413997 CDS YP_003046633.1 254163525 8177659 complement(3706075..3706437) 1 NC_012967.1 similar to b3598; putative inner membrane protein 3706437 yibI 8177659 yibI Escherichia coli B str. REL606 putative inner membrane protein YP_003046633.1 3706075 R 413997 CDS YP_003046634.1 254163526 8177660 3706974..3708887 1 NC_012967.1 similar to b3599; PTS system mannitol-specific transporter subunit IIABC 3708887 mtlA 8177660 mtlA Escherichia coli B str. REL606 PTS system mannitol-specific transporter subunit IIABC YP_003046634.1 3706974 D 413997 CDS YP_003046635.1 254163527 8177661 3709117..3710265 1 NC_012967.1 similar to b3600; mannitol-1-phosphate 5-dehydrogenase 3710265 mtlD 8177661 mtlD Escherichia coli B str. REL606 mannitol-1-phosphate 5-dehydrogenase YP_003046635.1 3709117 D 413997 CDS YP_003046636.1 254163528 8178748 3710265..3710852 1 NC_012967.1 Acts as a repressor of the mtlAD operon; mannitol repressor protein 3710852 mtlR 8178748 mtlR Escherichia coli B str. REL606 mannitol repressor protein YP_003046636.1 3710265 D 413997 CDS YP_003046637.1 254163529 8177662 complement(3710864..3711073) 1 NC_012967.1 similar to b4554; hypothetical protein 3711073 8177662 ECB_03457 Escherichia coli B str. REL606 hypothetical protein YP_003046637.1 3710864 R 413997 CDS YP_003046638.1 254163530 8178749 3711358..3711720 1 NC_012967.1 similar to b3602; hypothetical protein 3711720 yibL 8178749 yibL Escherichia coli B str. REL606 hypothetical protein YP_003046638.1 3711358 D 413997 CDS YP_003046639.1 254163531 8177663 3712264..3712947 1 NC_012967.1 hypothetical protein 3712947 8177663 ECB_03459 Escherichia coli B str. REL606 hypothetical protein YP_003046639.1 3712264 D 413997 CDS YP_003046640.1 254163532 8177664 3712991..3717841 1 NC_012967.1 putative adhesin 3717841 8177664 ECB_03460 Escherichia coli B str. REL606 putative adhesin YP_003046640.1 3712991 D 413997 CDS YP_003046641.1 254163533 8178750 3718209..3719864 1 NC_012967.1 similar to b3603; L-lactate permease 3719864 lldP 8178750 lldP Escherichia coli B str. REL606 L-lactate permease YP_003046641.1 3718209 D 413997 CDS YP_003046642.1 254163534 8177665 3719864..3720640 1 NC_012967.1 represses the lctPRD operon; DNA-binding transcriptional repressor LldR 3720640 lldR 8177665 lldR Escherichia coli B str. REL606 DNA-binding transcriptional repressor LldR YP_003046642.1 3719864 D 413997 CDS YP_003046643.1 254163535 8177666 3720637..3721827 1 NC_012967.1 flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration; L-lactate dehydrogenase 3721827 lldD 8177666 lldD Escherichia coli B str. REL606 L-lactate dehydrogenase YP_003046643.1 3720637 D 413997 CDS YP_003046644.1 254163536 8177667 3721981..3722454 1 NC_012967.1 member of the SPOUT superfamily of RNA methyltransferases; no methyltransferase activity observed with certain tRNA substrates; putative tRNA/rRNA methyltransferase YibK 3722454 yibK 8177667 yibK Escherichia coli B str. REL606 putative tRNA/rRNA methyltransferase YibK YP_003046644.1 3721981 D 413997 CDS YP_003046645.1 254163537 8177668 complement(3722507..3723328) 1 NC_012967.1 catalyzes the O-acetylation of serine; serine acetyltransferase 3723328 cysE 8177668 cysE Escherichia coli B str. REL606 serine acetyltransferase YP_003046645.1 3722507 R 413997 CDS YP_003046646.1 254163538 8179281 complement(3723408..3724427) 1 NC_012967.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 3724427 gpsA 8179281 gpsA Escherichia coli B str. REL606 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase YP_003046646.1 3723408 R 413997 CDS YP_003046647.1 254163539 8177669 complement(3724427..3724894) 1 NC_012967.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB 3724894 secB 8177669 secB Escherichia coli B str. REL606 preprotein translocase subunit SecB YP_003046647.1 3724427 R 413997 CDS YP_003046648.1 254163540 8177670 complement(3724957..3725208) 1 NC_012967.1 similar to b3610; glutaredoxin 3 3725208 grxC 8177670 grxC Escherichia coli B str. REL606 glutaredoxin 3 YP_003046648.1 3724957 R 413997 CDS YP_003046649.1 254163541 8177671 complement(3725350..3725781) 1 NC_012967.1 similar to b3611; putative rhodanese-related sulfurtransferase 3725781 yibN 8177671 yibN Escherichia coli B str. REL606 putative rhodanese-related sulfurtransferase YP_003046649.1 3725350 R 413997 CDS YP_003046650.1 254163542 8177672 3726026..3727570 1 NC_012967.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate; phosphoglyceromutase 3727570 yibO 8177672 yibO Escherichia coli B str. REL606 phosphoglyceromutase YP_003046650.1 3726026 D 413997 CDS YP_003046651.1 254163543 8179282 3727604..3728863 1 NC_012967.1 similar to b3613; hypothetical protein 3728863 yibP 8179282 yibP Escherichia coli B str. REL606 hypothetical protein YP_003046651.1 3727604 D 413997 CDS YP_003046652.1 254163544 8177673 3728867..3729826 1 NC_012967.1 similar to b3614; putative polysaccharide deacetylase 3729826 yibQ 8177673 yibQ Escherichia coli B str. REL606 putative polysaccharide deacetylase YP_003046652.1 3728867 D 413997 CDS YP_003046653.1 254163545 8177674 complement(3729813..3730847) 1 NC_012967.1 similar to b3615; putative glycosyl transferase 3730847 yibD 8177674 yibD Escherichia coli B str. REL606 putative glycosyl transferase YP_003046653.1 3729813 R 413997 CDS YP_003046654.1 254163546 8177675 complement(3731086..3732111) 1 NC_012967.1 converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism; L-threonine 3-dehydrogenase 3732111 tdh 8177675 tdh Escherichia coli B str. REL606 L-threonine 3-dehydrogenase YP_003046654.1 3731086 R 413997 CDS YP_003046655.1 254163547 8177676 complement(3732121..3733317) 1 NC_012967.1 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine; 2-amino-3-ketobutyrate coenzyme A ligase 3733317 kbl 8177676 kbl Escherichia coli B str. REL606 2-amino-3-ketobutyrate coenzyme A ligase YP_003046655.1 3732121 R 413997 CDS YP_003046656.1 254163548 8178751 3733531..3734463 1 NC_012967.1 catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose; ADP-L-glycero-D-mannoheptose-6-epimerase 3734463 rfaD 8178751 rfaD Escherichia coli B str. REL606 ADP-L-glycero-D-mannoheptose-6-epimerase YP_003046656.1 3733531 D 413997 CDS YP_003046657.1 254163549 8177677 3734473..3735519 1 NC_012967.1 catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core; ADP-heptose:LPS heptosyltransferase II 3735519 waaF 8177677 waaF Escherichia coli B str. REL606 ADP-heptose:LPS heptosyltransferase II YP_003046657.1 3734473 D 413997 CDS YP_003046658.1 254163550 8178752 3735523..3736503 1 NC_012967.1 similar to b3621; ADP-heptose:LPS heptosyl transferase I 3736503 waaC 8178752 waaC Escherichia coli B str. REL606 ADP-heptose:LPS heptosyl transferase I YP_003046658.1 3735523 D 413997 CDS YP_003046659.1 254163551 8177678 complement(3736573..3737826) 1 NC_012967.1 Lipid A-core, surface polymer ligase 3737826 waaL 8177678 waaL Escherichia coli B str. REL606 Lipid A-core, surface polymer ligase YP_003046659.1 3736573 R 413997 CDS YP_003046660.1 254163552 8177679 complement(3737872..3738855) 1 NC_012967.1 putative beta1,3-glucosyltransferase 3738855 waaV 8177679 waaV Escherichia coli B str. REL606 putative beta1,3-glucosyltransferase YP_003046660.1 3737872 R 413997 CDS YP_003046661.1 254163553 8178753 complement(3738940..3739965) 1 NC_012967.1 UDP-galactose:(Galactosyl) LPS alpha1,2-galactosyltransferase 3739965 waaW 8178753 waaW Escherichia coli B str. REL606 UDP-galactose:(Galactosyl) LPS alpha1,2-galactosyltransferase YP_003046661.1 3738940 R 413997 CDS YP_003046662.1 254163554 8177680 complement(3739991..3740539) 1 NC_012967.1 lipopolysaccharide core biosynthesis protein 3740539 waaY 8177680 waaY Escherichia coli B str. REL606 lipopolysaccharide core biosynthesis protein YP_003046662.1 3739991 R 413997 CDS YP_003046663.1 254163555 8177682 complement(3741213..3741716) 1 NC_012967.1 IS1 protein InsB 3741716 insB-24 8177682 insB-24 Escherichia coli B str. REL606 IS1 protein InsB YP_003046663.1 3741213 R 413997 CDS YP_003046664.1 254163556 8177683 complement(3741635..3741910) 1 NC_012967.1 IS1 protein InsA 3741910 insA-24 8177683 insA-24 Escherichia coli B str. REL606 IS1 protein InsA YP_003046664.1 3741635 R 413997 CDS YP_003046665.1 254163557 8179283 complement(3742481..3743497) 1 NC_012967.1 UDP-glucose:(Glucosyl) LPS alpha1,3-glucosyltransferase WaaO 3743497 waaO 8179283 waaO Escherichia coli B str. REL606 UDP-glucose:(Glucosyl) LPS alpha1,3-glucosyltransferase WaaO YP_003046665.1 3742481 R 413997 CDS YP_003046666.1 254163558 8177684 complement(3743513..3744319) 1 NC_012967.1 similar to b3630; kinase that phosphorylates core heptose of lipopolysaccharide 3744319 waaP 8177684 waaP Escherichia coli B str. REL606 kinase that phosphorylates core heptose of lipopolysaccharide YP_003046666.1 3743513 R 413997 CDS YP_003046667.1 254163559 8177685 complement(3744303..3745427) 1 NC_012967.1 similar to b3631; glucosyltransferase I 3745427 waaG 8177685 waaG Escherichia coli B str. REL606 glucosyltransferase I YP_003046667.1 3744303 R 413997 CDS YP_003046668.1 254163560 8177686 complement(3745424..3746482) 1 NC_012967.1 similar to b3632; lipopolysaccharide core biosynthesis protein 3746482 waaQ 8177686 waaQ Escherichia coli B str. REL606 lipopolysaccharide core biosynthesis protein YP_003046668.1 3745424 R 413997 CDS YP_003046669.1 254163561 8177687 3746895..3748172 1 NC_012967.1 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A; 3-deoxy-D-manno-octulosonic-acid transferase 3748172 waaA 8177687 waaA Escherichia coli B str. REL606 3-deoxy-D-manno-octulosonic-acid transferase YP_003046669.1 3746895 D 413997 CDS YP_003046670.1 254163562 8179284 3748180..3748659 1 NC_012967.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 3748659 coaD 8179284 coaD Escherichia coli B str. REL606 phosphopantetheine adenylyltransferase YP_003046670.1 3748180 D 413997 CDS YP_003046671.1 254163563 8177688 complement(3748698..3749507) 1 NC_012967.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 3749507 mutM 8177688 mutM Escherichia coli B str. REL606 formamidopyrimidine-DNA glycosylase YP_003046671.1 3748698 R 413997 CDS YP_003046672.1 254163564 8177689 complement(3749605..3749772) 1 NC_012967.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 3749772 rpmG 8177689 rpmG Escherichia coli B str. REL606 50S ribosomal protein L33 YP_003046672.1 3749605 R 413997 CDS YP_003046673.1 254163565 8178754 complement(3749793..3750029) 1 NC_012967.1 required for 70S ribosome assembly; 50S ribosomal protein L28 3750029 rpmB 8178754 rpmB Escherichia coli B str. REL606 50S ribosomal protein L28 YP_003046673.1 3749793 R 413997 CDS YP_003046674.1 254163566 8177690 complement(3750246..3750914) 1 NC_012967.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC 3750914 radC 8177690 radC Escherichia coli B str. REL606 DNA repair protein RadC YP_003046674.1 3750246 R 413997 CDS YP_003046675.1 254163567 8177691 3751086..3752306 1 NC_012967.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 3752306 dfp 8177691 dfp Escherichia coli B str. REL606 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase YP_003046675.1 3751086 D 413997 CDS YP_003046676.1 254163568 8179285 3752287..3752742 1 NC_012967.1 catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 3752742 dut 8179285 dut Escherichia coli B str. REL606 deoxyuridine 5'-triphosphate nucleotidohydrolase YP_003046676.1 3752287 D 413997 CDS YP_003046677.1 254163569 8177692 3752849..3753445 1 NC_012967.1 FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly; nucleoid occlusion protein 3753445 slmA 8177692 slmA Escherichia coli B str. REL606 nucleoid occlusion protein YP_003046677.1 3752849 D 413997 CDS YP_003046678.1 254163570 8177693 complement(3753482..3754123) 1 NC_012967.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 3754123 pyrE 8177693 pyrE Escherichia coli B str. REL606 orotate phosphoribosyltransferase YP_003046678.1 3753482 R 413997 CDS YP_003046679.1 254163571 8179286 complement(3754189..3754905) 1 NC_012967.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 3754905 rph 8179286 rph Escherichia coli B str. REL606 ribonuclease PH YP_003046679.1 3754189 R 413997 CDS YP_003046680.1 254163572 8177694 3755032..3755895 1 NC_012967.1 similar to b3644; hypothetical protein 3755895 yicC 8177694 yicC Escherichia coli B str. REL606 hypothetical protein YP_003046680.1 3755032 D 413997 CDS YP_003046681.1 254163573 8177695 3756104..3756940 1 NC_012967.1 similar to b3645; DNA-damage-inducible protein D 3756940 dinD 8177695 dinD Escherichia coli B str. REL606 DNA-damage-inducible protein D YP_003046681.1 3756104 D 413997 CDS YP_003046682.1 254163574 8177696 3757231..3757848 1 NC_012967.1 similar to b3646; inner membrane protein 3757848 yicG 8177696 yicG Escherichia coli B str. REL606 inner membrane protein YP_003046682.1 3757231 D 413997 CDS YP_003046683.1 254163575 8177697 complement(3757845..3759527) 1 NC_012967.1 this ligase is similar to LigA but it lacks the C-terminal BRCT domain; catalyzes strand joining of nicked DNA in the presence of a divalent cation and NAD+; NAD-dependent DNA ligase LigB 3759527 ligB 8177697 ligB Escherichia coli B str. REL606 NAD-dependent DNA ligase LigB YP_003046683.1 3757845 R 413997 CDS YP_003046684.1 254163576 8177698 3759785..3760408 1 NC_012967.1 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 3760408 gmk 8177698 gmk Escherichia coli B str. REL606 guanylate kinase YP_003046684.1 3759785 D 413997 CDS YP_003046685.1 254163577 8177699 3760463..3760738 1 NC_012967.1 promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 3760738 rpoZ 8177699 rpoZ Escherichia coli B str. REL606 DNA-directed RNA polymerase subunit omega YP_003046685.1 3760463 D 413997 CDS YP_003046686.1 254163578 8178755 3760757..3762865 1 NC_012967.1 similar to b3650; bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 3762865 spoT 8178755 spoT Escherichia coli B str. REL606 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase YP_003046686.1 3760757 D 413997 CDS YP_003046687.1 254163579 8178756 3762872..3763561 1 NC_012967.1 specifically modifies tRNA at position G18; tRNA guanosine-2'-O-methyltransferase 3763561 trmH 8178756 trmH Escherichia coli B str. REL606 tRNA guanosine-2'-O-methyltransferase YP_003046687.1 3762872 D 413997 CDS YP_003046688.1 254163580 8177700 3763567..3765648 1 NC_012967.1 catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 3765648 recG 8177700 recG Escherichia coli B str. REL606 ATP-dependent DNA helicase RecG YP_003046688.1 3763567 D 413997 CDS YP_003046689.1 254163581 8179287 complement(3765633..3766427) 1 NC_012967.1 hypothetical protein 3766427 8179287 ECB_03510 Escherichia coli B str. REL606 hypothetical protein YP_003046689.1 3765633 R 413997 CDS YP_003046690.1 254163582 8177701 complement(3766502..3767707) 1 NC_012967.1 similar to b3653; glutamate transporter 3767707 gltS 8177701 gltS Escherichia coli B str. REL606 glutamate transporter YP_003046690.1 3766502 R 413997 CDS YP_003046691.1 254163583 8177702 3767987..3769378 1 NC_012967.1 similar to b3654; putative transporter 3769378 yicE 8177702 yicE Escherichia coli B str. REL606 putative transporter YP_003046691.1 3767987 D 413997 CDS YP_003046692.1 254163584 8177703 3769499..3771208 1 NC_012967.1 similar to b3655; hypothetical protein 3771208 yicH 8177703 yicH Escherichia coli B str. REL606 hypothetical protein YP_003046692.1 3769499 D 413997 CDS YP_003046693.1 254163585 8177704 complement(3771261..3773579) 1 NC_012967.1 catalyzes the transfer of alpha-xylosyl residue from alpha-xyloside to xylose, glucose, mannose, fructose, maltose, isomaltose, nigerose, kojibiose, sucrose, and trehalose; shows higher activity against alpha-xylosyl fluoride, isoprimeverose (6-O-alpha-xylopyranosyl-glucopyranose), and alpha-xyloside in xyloglucan oligosaccharides; alpha-xylosidase YicI 3773579 yicI 8177704 yicI Escherichia coli B str. REL606 alpha-xylosidase YicI YP_003046693.1 3771261 R 413997 CDS YP_003046694.1 254163586 8177705 complement(3773589..3774971) 1 NC_012967.1 may be involved in the transport of galactosides-pentoses-hexuronides; putative transporter 3774971 yicJ 8177705 yicJ Escherichia coli B str. REL606 putative transporter YP_003046694.1 3773589 R 413997 CDS YP_003046695.1 254163587 8179288 3775658..3776842 1 NC_012967.1 Int 3776842 8179288 ECB_03516 Escherichia coli B str. REL606 Int YP_003046695.1 3775658 D 413997 CDS YP_003046696.1 254163588 8177707 3777253..3778296 1 NC_012967.1 ShiA-like protein 3778296 8177707 ECB_03517 Escherichia coli B str. REL606 ShiA-like protein YP_003046696.1 3777253 D 413997 CDS YP_003046697.1 254163589 8177708 3778439..3778669 1 NC_012967.1 hypothetical protein 3778669 8177708 ECB_03518 Escherichia coli B str. REL606 hypothetical protein YP_003046697.1 3778439 D 413997 CDS YP_003046698.1 254163590 8179289 complement(3778694..3779788) 1 NC_012967.1 putative transcriptional regulator 3779788 8179289 ECB_03519 Escherichia coli B str. REL606 putative transcriptional regulator YP_003046698.1 3778694 R 413997 CDS YP_003046699.1 254163591 8177709 3779969..3781327 1 NC_012967.1 hypothetical protein 3781327 8177709 ECB_03520 Escherichia coli B str. REL606 hypothetical protein YP_003046699.1 3779969 D 413997 CDS YP_003046700.1 254163592 8177710 3781336..3783723 1 NC_012967.1 hypothetical protein 3783723 8177710 ECB_03521 Escherichia coli B str. REL606 hypothetical protein YP_003046700.1 3781336 D 413997 CDS YP_003046701.1 254163593 8177711 3784371..3784856 1 NC_012967.1 Single-strand binding protein (SSB) (Helix-destabilizing protein) 3784856 8177711 ECB_03522 Escherichia coli B str. REL606 Single-strand binding protein (SSB) (Helix-destabilizing protein) YP_003046701.1 3784371 D 413997 CDS YP_003046702.1 254163594 8177712 3784910..3786073 1 NC_012967.1 TrbC-like protein 3786073 8177712 ECB_03523 Escherichia coli B str. REL606 TrbC-like protein YP_003046702.1 3784910 D 413997 CDS YP_003046703.1 254163595 8177713 complement(3785920..3786267) 1 NC_012967.1 transposase 3786267 8177713 ECB_03524 Escherichia coli B str. REL606 transposase YP_003046703.1 3785920 R 413997 CDS YP_003046704.1 254163596 8177714 complement(3786384..3786722) 1 NC_012967.1 hypothetical protein 3786722 8177714 ECB_03525 Escherichia coli B str. REL606 hypothetical protein YP_003046704.1 3786384 R 413997 CDS YP_003046705.1 254163597 8178757 complement(3786807..3786962) 1 NC_012967.1 hypothetical protein 3786962 8178757 ECB_03526 Escherichia coli B str. REL606 hypothetical protein YP_003046705.1 3786807 R 413997 CDS YP_003046706.1 254163598 8178758 3787090..3787392 1 NC_012967.1 hypothetical protein 3787392 8178758 ECB_03527 Escherichia coli B str. REL606 hypothetical protein YP_003046706.1 3787090 D 413997 CDS YP_003046707.1 254163599 8178759 complement(3787959..3788213) 1 NC_012967.1 hypothetical protein 3788213 8178759 ECB_03530 Escherichia coli B str. REL606 hypothetical protein YP_003046707.1 3787959 R 413997 CDS YP_003046708.1 254163600 8177716 3788241..3791738 1 NC_012967.1 hypothetical protein 3791738 8177716 ECB_03531 Escherichia coli B str. REL606 hypothetical protein YP_003046708.1 3788241 D 413997 CDS YP_003046709.1 254163601 8177717 3791895..3792308 1 NC_012967.1 hypothetical protein 3792308 8177717 ECB_03532 Escherichia coli B str. REL606 hypothetical protein YP_003046709.1 3791895 D 413997 CDS YP_003046710.1 254163602 8177718 complement(3792373..3792555) 1 NC_012967.1 hypothetical protein 3792555 8177718 ECB_03533 Escherichia coli B str. REL606 hypothetical protein YP_003046710.1 3792373 R 413997 CDS YP_003046711.1 254163603 8177719 complement(3792598..3792744) 1 NC_012967.1 hypothetical protein 3792744 8177719 ECB_03534 Escherichia coli B str. REL606 hypothetical protein YP_003046711.1 3792598 R 413997 CDS YP_003046712.1 254163604 8177720 3792771..3793127 1 NC_012967.1 similar to b4505; putative IS protein 3793127 ykgN 8177720 ykgN Escherichia coli B str. REL606 putative IS protein YP_003046712.1 3792771 D 413997 CDS YP_003046713.1 254163605 8177721 3793084..3794208 1 NC_012967.1 IS30 transposase 3794208 insI 8177721 insI Escherichia coli B str. REL606 IS30 transposase YP_003046713.1 3793084 D 413997 CDS YP_003046714.1 254163606 8179290 3794106..3794471 1 NC_012967.1 hypothetical protein 3794471 8179290 ECB_03537 Escherichia coli B str. REL606 hypothetical protein YP_003046714.1 3794106 D 413997 CDS YP_003046715.1 254163607 8177722 3794468..3794956 1 NC_012967.1 hypothetical protein 3794956 8177722 ECB_03538 Escherichia coli B str. REL606 hypothetical protein YP_003046715.1 3794468 D 413997 CDS YP_003046716.1 254163608 8177723 3794923..3795165 1 NC_012967.1 Aec78 3795165 8177723 ECB_03539 Escherichia coli B str. REL606 Aec78 YP_003046716.1 3794923 D 413997 CDS YP_003046717.1 254163609 8179291 3795250..3796095 1 NC_012967.1 hypothetical protein 3796095 8179291 ECB_03540 Escherichia coli B str. REL606 hypothetical protein YP_003046717.1 3795250 D 413997 CDS YP_003046718.1 254163610 8177724 3796354..3796503 1 NC_012967.1 hypothetical protein 3796503 8177724 ECB_03541 Escherichia coli B str. REL606 hypothetical protein YP_003046718.1 3796354 D 413997 CDS YP_003046719.1 254163611 8177725 3796885..3798069 1 NC_012967.1 similar to b3659; putative sugar efflux system 3798069 yicK 8177725 yicK Escherichia coli B str. REL606 putative sugar efflux system YP_003046719.1 3796885 D 413997 CDS YP_003046720.1 254163612 8177726 3798180..3799103 1 NC_012967.1 similar to b3660; putative inner membrane protein 3799103 yicL 8177726 yicL Escherichia coli B str. REL606 putative inner membrane protein YP_003046720.1 3798180 D 413997 CDS YP_003046721.1 254163613 8177727 complement(3799107..3799925) 1 NC_012967.1 similar to b3661; cytoplasmic membrane lipoprotein-28 3799925 nlpA 8177727 nlpA Escherichia coli B str. REL606 cytoplasmic membrane lipoprotein-28 YP_003046721.1 3799107 R 413997 CDS YP_003046722.1 254163614 8177728 3800147..3800440 1 NC_012967.1 similar to b4555; hypothetical protein 3800440 8177728 ECB_03545 Escherichia coli B str. REL606 hypothetical protein YP_003046722.1 3800147 D 413997 CDS YP_003046723.1 254163615 8177729 complement(3800481..3801836) 1 NC_012967.1 experimental results in Escherichia coli suggest that this gene encodes an inosine export protein; member of major facilitator superfamily; MFS; ribonucleoside transporter 3801836 nepI 8177729 nepI Escherichia coli B str. REL606 ribonucleoside transporter YP_003046723.1 3800481 R 413997 CDS YP_003046724.1 254163616 8178760 complement(3801882..3802334) 1 NC_012967.1 similar to b3663; hypothetical protein 3802334 yicN 8178760 yicN Escherichia coli B str. REL606 hypothetical protein YP_003046724.1 3801882 R 413997 CDS YP_003046725.1 254163617 8178761 complement(3802387..3803721) 1 NC_012967.1 similar to b3664; putative xanthine/uracil permase 3803721 yicO 8178761 yicO Escherichia coli B str. REL606 putative xanthine/uracil permase YP_003046725.1 3802387 R 413997 CDS YP_003046726.1 254163618 8177730 3803896..3805662 1 NC_012967.1 catalyzes the formation of hypoxanthine from adenine; in E. coli this activity has been detected in mutant strains but not in wild type; cryptic adenine deaminase 3805662 ade 8177730 ade Escherichia coli B str. REL606 cryptic adenine deaminase YP_003046726.1 3803896 D 413997 CDS YP_003046727.1 254163619 8178762 complement(3805708..3807099) 1 NC_012967.1 cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate; sugar phosphate antiporter 3807099 uhpT 8178762 uhpT Escherichia coli B str. REL606 sugar phosphate antiporter YP_003046727.1 3805708 R 413997 CDS YP_003046728.1 254163620 8177731 complement(3807237..3808556) 1 NC_012967.1 membrane protein regulates uhpT expression; regulatory protein UhpC 3808556 uhpC 8177731 uhpC Escherichia coli B str. REL606 regulatory protein UhpC YP_003046728.1 3807237 R 413997 CDS YP_003046729.1 254163621 8177732 complement(3808566..3810068) 1 NC_012967.1 Member of the two-component regulatory system UhpB/UhpA involved in the regulation of the uptake of hexose ph; sensory histidine kinase UhpB 3810068 uhpB 8177732 uhpB Escherichia coli B str. REL606 sensory histidine kinase UhpB YP_003046729.1 3808566 R 413997 CDS YP_003046730.1 254163622 8177733 complement(3810068..3810658) 1 NC_012967.1 response regulator in two-component regulatory system wtih UhpB; phosphorylated UhpA is a positive activator uhpT, a hexose phosphates transporter; DNA-binding transcriptional activator UhpA 3810658 uhpA 8177733 uhpA Escherichia coli B str. REL606 DNA-binding transcriptional activator UhpA YP_003046730.1 3810068 R 413997 CDS YP_003046731.1 254163623 8177734 complement(3810733..3811023) 1 NC_012967.1 with IlvB catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase small subunit; acetolactate synthase 1 regulatory subunit 3811023 ilvN 8177734 ilvN Escherichia coli B str. REL606 acetolactate synthase 1 regulatory subunit YP_003046731.1 3810733 R 413997 CDS YP_003046732.1 254163624 8177735 complement(3811027..3812715) 1 NC_012967.1 similar to b3671; acetolactate synthase catalytic subunit 3812715 ilvB 8177735 ilvB Escherichia coli B str. REL606 acetolactate synthase catalytic subunit YP_003046732.1 3811027 R 413997 CDS YP_003046733.1 254163625 8177736 complement(3812821..3812919) 1 NC_012967.1 similar to b3672; ilvB operon leader peptide 3812919 ivbL 8177736 ivbL Escherichia coli B str. REL606 ilvB operon leader peptide YP_003046733.1 3812821 R 413997 CDS YP_003046734.1 254163626 8179292 3813853..3815037 1 NC_012967.1 multidrug efflux protein involved in adaptation to low energy shock; multidrug resistance protein D 3815037 emrD 8179292 emrD Escherichia coli B str. REL606 multidrug resistance protein D YP_003046734.1 3813853 D 413997 CDS YP_003046735.1 254163627 8177737 complement(3815045..3815542) 1 NC_012967.1 similar to b3674; putative DNA-binding transcriptional regulator 3815542 yidF 8177737 yidF Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003046735.1 3815045 R 413997 CDS YP_003046736.1 254163628 8177738 complement(3815539..3815901) 1 NC_012967.1 similar to b3675; putative inner membrane protein 3815901 yidG 8177738 yidG Escherichia coli B str. REL606 putative inner membrane protein YP_003046736.1 3815539 R 413997 CDS YP_003046737.1 254163629 8179293 complement(3815891..3816238) 1 NC_012967.1 similar to b3676; inner membrane protein 3816238 yidH 8179293 yidH Escherichia coli B str. REL606 inner membrane protein YP_003046737.1 3815891 R 413997 CDS YP_003046738.1 254163630 8177739 3816347..3816796 1 NC_012967.1 similar to b3677; putative inner membrane protein 3816796 yidI 8177739 yidI Escherichia coli B str. REL606 putative inner membrane protein YP_003046738.1 3816347 D 413997 CDS YP_003046739.1 254163631 8177740 complement(3816843..3818336) 1 NC_012967.1 similar to b3678; putative sulfatase/phosphatase 3818336 yidJ 8177740 yidJ Escherichia coli B str. REL606 putative sulfatase/phosphatase YP_003046739.1 3816843 R 413997 CDS YP_003046740.1 254163632 8177741 complement(3818333..3820048) 1 NC_012967.1 uncharacterized member of the SSS superfamily of sodium-dependent solute transporters; unknown function; putative symporter YidK 3820048 yidK 8177741 yidK Escherichia coli B str. REL606 putative symporter YidK YP_003046740.1 3818333 R 413997 CDS YP_003046741.1 254163633 8177742 3820185..3821108 1 NC_012967.1 similar to b3680; putative DNA-binding transcriptional regulator 3821108 yidL 8177742 yidL Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003046741.1 3820185 D 413997 CDS YP_003046742.1 254163634 8177743 complement(3821105..3822427) 1 NC_012967.1 similar to b3681; truncated in K-12 MG1655; putative 6-phospho-beta-glucosidase 3822427 glvG 8177743 glvG Escherichia coli B str. REL606 putative 6-phospho-beta-glucosidase YP_003046742.1 3821105 R 413997 CDS YP_003046743.1 254163635 8177744 complement(3822427..3824043) 1 NC_012967.1 similar to b3682-b3683; PTS system arbutin-specific transporter subunit IIBC 3824043 glvBC 8177744 glvBC Escherichia coli B str. REL606 PTS system arbutin-specific transporter subunit IIBC YP_003046743.1 3822427 R 413997 CDS YP_003046744.1 254163636 8177745 complement(3824973..3826634) 1 NC_012967.1 similar to b3685; hypothetical protein 3826634 yidE 8177745 yidE Escherichia coli B str. REL606 hypothetical protein YP_003046744.1 3824973 R 413997 CDS YP_003046745.1 254163637 8177746 complement(3826830..3827231) 1 NC_012967.1 16 kDa heat shock protein B; associates with aggregated proteins, together with ibpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; ATP-independent; heat shock chaperone IbpB 3827231 ibpB 8177746 ibpB Escherichia coli B str. REL606 heat shock chaperone IbpB YP_003046745.1 3826830 R 413997 CDS YP_003046746.1 254163638 8178764 complement(3827370..3827783) 1 NC_012967.1 with IbpB associates with aggregated proteins to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; heat shock protein IbpA 3827783 ibpA 8178764 ibpA Escherichia coli B str. REL606 heat shock protein IbpA YP_003046746.1 3827370 R 413997 CDS YP_003046747.1 254163639 8177747 3828089..3828421 1 NC_012967.1 similar to b3688; hypothetical protein 3828421 yidQ 8177747 yidQ Escherichia coli B str. REL606 hypothetical protein YP_003046747.1 3828089 D 413997 CDS YP_003046748.1 254163640 8177748 complement(3828423..3829637) 1 NC_012967.1 similar to b3689; hypothetical protein 3829637 yidR 8177748 yidR Escherichia coli B str. REL606 hypothetical protein YP_003046748.1 3828423 R 413997 CDS YP_003046749.1 254163641 8177749 3829738..3830802 1 NC_012967.1 FAD/NAD(P)-binding domain; putative oxidoreductase 3830802 yidS 8177749 yidS Escherichia coli B str. REL606 putative oxidoreductase YP_003046749.1 3829738 D 413997 CDS YP_003046750.1 254163642 8177750 complement(3830799..3832091) 1 NC_012967.1 similar to b3691; D-galactonate transporter 3832091 dgoT 8177750 dgoT Escherichia coli B str. REL606 D-galactonate transporter YP_003046750.1 3830799 R 413997 CDS YP_003046751.1 254163643 8177751 complement(3832211..3833359) 1 NC_012967.1 similar to b4478; galactonate dehydratase 3833359 dgoD 8177751 dgoD Escherichia coli B str. REL606 galactonate dehydratase YP_003046751.1 3832211 R 413997 CDS YP_003046752.1 254163644 8178765 complement(3833356..3833973) 1 NC_012967.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-galactonate 6-phosphate; functions in galactonate metabolism; 2-dehydro-3-deoxy-6-phosphogalactonate aldolase 3833973 dgoA 8178765 dgoA Escherichia coli B str. REL606 2-dehydro-3-deoxy-6-phosphogalactonate aldolase YP_003046752.1 3833356 R 413997 CDS YP_003046753.1 254163645 8177752 complement(3833957..3834835) 1 NC_012967.1 similar to b3693; 2-oxo-3-deoxygalactonate kinase 3834835 dgoK 8177752 dgoK Escherichia coli B str. REL606 2-oxo-3-deoxygalactonate kinase YP_003046753.1 3833957 R 413997 CDS YP_003046754.1 254163646 8177753 complement(3834832..3835521) 1 NC_012967.1 similar to b4479; putative DNA-binding transcriptional regulator 3835521 dgoR 8177753 dgoR Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003046754.1 3834832 R 413997 CDS YP_003046755.1 254163647 8177754 3835799..3836455 1 NC_012967.1 similar to b3696; hypothetical protein 3836455 yidX 8177754 yidX Escherichia coli B str. REL606 hypothetical protein YP_003046755.1 3835799 D 413997 CDS YP_003046756.1 254163648 8177755 complement(3836501..3837313) 1 NC_012967.1 YidA; catalyzes the dephosphorylation of erythrose 4-phosphate (preferred substrate), mannose 1-phosphate and p-nitrophenyl phosphate; hydrolyzes the alpha-D-glucose-1-phosphate but not the beta form; member of the haloacid dehalogenase-like hydrolases superfamily and Cof family of proteins; sugar phosphatase 3837313 yidA 8177755 yidA Escherichia coli B str. REL606 sugar phosphatase YP_003046756.1 3836501 R 413997 CDS YP_003046757.1 254163649 8178766 complement(3837428..3837826) 1 NC_012967.1 similar to b3698; hypothetical protein 3837826 yidB 8178766 yidB Escherichia coli B str. REL606 hypothetical protein YP_003046757.1 3837428 R 413997 CDS YP_003046758.1 254163650 8177756 complement(3838066..3840480) 1 NC_012967.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 3840480 gyrB 8177756 gyrB Escherichia coli B str. REL606 DNA gyrase subunit B YP_003046758.1 3838066 R 413997 CDS YP_003046759.1 254163651 8177757 complement(3840509..3841582) 1 NC_012967.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 3841582 recF 8177757 recF Escherichia coli B str. REL606 recombination protein F YP_003046759.1 3840509 R 413997 CDS YP_003046760.1 254163652 8177758 complement(3841582..3842682) 1 NC_012967.1 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 3842682 dnaN 8177758 dnaN Escherichia coli B str. REL606 DNA polymerase III subunit beta YP_003046760.1 3841582 R 413997 CDS YP_003046761.1 254163653 8177759 complement(3842687..3844090) 1 NC_012967.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 3844090 dnaA 8177759 dnaA Escherichia coli B str. REL606 chromosomal replication initiation protein YP_003046761.1 3842687 R 413997 CDS YP_003046762.1 254163654 8178767 3844697..3844837 1 NC_012967.1 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 3844837 rpmH 8178767 rpmH Escherichia coli B str. REL606 50S ribosomal protein L34 YP_003046762.1 3844697 D 413997 CDS YP_003046763.1 254163655 8177760 3844854..3845213 1 NC_012967.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 3845213 rnpA 8177760 rnpA Escherichia coli B str. REL606 ribonuclease P YP_003046763.1 3844854 D 413997 CDS YP_003046764.1 254163656 8177761 3845177..3845434 1 NC_012967.1 similar to b4557; hypothetical protein 3845434 yidD 8177761 yidD Escherichia coli B str. REL606 hypothetical protein YP_003046764.1 3845177 D 413997 CDS YP_003046765.1 254163657 8177762 3845437..3847083 1 NC_012967.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; putative inner membrane protein translocase component YidC 3847083 yidC 8177762 yidC Escherichia coli B str. REL606 putative inner membrane protein translocase component YidC YP_003046765.1 3845437 D 413997 CDS YP_003046766.1 254163658 8177763 3847189..3848553 1 NC_012967.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 3848553 trmE 8177763 trmE Escherichia coli B str. REL606 tRNA modification GTPase TrmE YP_003046766.1 3847189 D 413997 CDS YP_003046767.1 254163659 8179294 3848796..3848870 1 NC_012967.1 similar to b3707; tryptophanase leader peptide 3848870 tnaL 8179294 tnaL Escherichia coli B str. REL606 tryptophanase leader peptide YP_003046767.1 3848796 D 413997 CDS YP_003046768.1 254163660 8177764 3849091..3850506 1 NC_012967.1 tryptophan indole-lyase; catalyzes the formation of indole and pyruvate from tryptophan; tryptophanase 3850506 tnaA 8177764 tnaA Escherichia coli B str. REL606 tryptophanase YP_003046768.1 3849091 D 413997 CDS YP_003046769.1 254163661 8177765 3850597..3851844 1 NC_012967.1 tryptophan transporter of low affinity; tryptophan permease TnaB 3851844 tnaB 8177765 tnaB Escherichia coli B str. REL606 tryptophan permease TnaB YP_003046769.1 3850597 D 413997 CDS YP_003046770.1 254163662 8179295 3851976..3853151 1 NC_012967.1 Confers resistance to chloramphenicol; multidrug efflux system protein MdtL 3853151 yidY 8179295 yidY Escherichia coli B str. REL606 multidrug efflux system protein MdtL YP_003046770.1 3851976 D 413997 CDS YP_003046771.1 254163663 8177766 3853126..3854085 1 NC_012967.1 Involved in anaerobic NO protection; DNA-binding transcriptional regulator YidZ 3854085 yidZ 8177766 yidZ Escherichia coli B str. REL606 DNA-binding transcriptional regulator YidZ YP_003046771.1 3853126 D 413997 CDS YP_003046772.1 254163664 8178768 3854230..3854991 1 NC_012967.1 similar to b3712; putative phosphopantetheinyl transferase 3854991 yieE 8178768 yieE Escherichia coli B str. REL606 putative phosphopantetheinyl transferase YP_003046772.1 3854230 D 413997 CDS YP_003046773.1 254163665 8177767 3855013..3855579 1 NC_012967.1 similar to b3713; chromate reductase, Class I, flavoprotein 3855579 yieF 8177767 yieF Escherichia coli B str. REL606 chromate reductase, Class I, flavoprotein YP_003046773.1 3855013 D 413997 CDS YP_003046774.1 254163666 8177768 complement(3855633..3856970) 1 NC_012967.1 similar to b3714; putative inner membrane protein 3856970 yieG 8177768 yieG Escherichia coli B str. REL606 putative inner membrane protein YP_003046774.1 3855633 R 413997 CDS YP_003046775.1 254163667 8177769 3857137..3857802 1 NC_012967.1 YieH; catalyzes the dephosphorylation of phosphoenolpyruvate, AMP and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; member of the haloacid dehalogenase-like hydrolases superfamily; 6-phosphogluconate phosphatase 3857802 yieH 8177769 yieH Escherichia coli B str. REL606 6-phosphogluconate phosphatase YP_003046775.1 3857137 D 413997 CDS YP_003046776.1 254163668 8177770 3857869..3858342 1 NC_012967.1 might be involved in hypersensitivity to nitrofurzone; putative inner membrane protein 3858342 yieI 8177770 yieI Escherichia coli B str. REL606 putative inner membrane protein YP_003046776.1 3857869 D 413997 CDS YP_003046777.1 254163669 8178769 3858391..3858978 1 NC_012967.1 similar to b3717; hypothetical protein 3858978 yieJ 8178769 yieJ Escherichia coli B str. REL606 hypothetical protein YP_003046777.1 3858391 D 413997 CDS YP_003046778.1 254163670 8177771 complement(3859040..3859762) 1 NC_012967.1 similar to b3718; putative 6-phosphogluconolactonase 3859762 yieK 8177771 yieK Escherichia coli B str. REL606 putative 6-phosphogluconolactonase YP_003046778.1 3859040 R 413997 CDS YP_003046779.1 254163671 8177772 complement(3859777..3860973) 1 NC_012967.1 similar to b3719; putative xylanase 3860973 yieL 8177772 yieL Escherichia coli B str. REL606 putative xylanase YP_003046779.1 3859777 R 413997 CDS YP_003046780.1 254163672 8177773 complement(3860973..3862589) 1 NC_012967.1 similar to b3720; carbohydrate-specific outer membrane porin, cryptic 3862589 yieC 8177773 yieC Escherichia coli B str. REL606 carbohydrate-specific outer membrane porin, cryptic YP_003046780.1 3860973 R 413997 CDS YP_003046781.1 254163673 8177774 complement(3862675..3864069) 1 NC_012967.1 similar to b3721; cryptic phospho-beta-glucosidase B 3864069 bglB 8177774 bglB Escherichia coli B str. REL606 cryptic phospho-beta-glucosidase B YP_003046781.1 3862675 R 413997 CDS YP_003046782.1 254163674 8178770 complement(3864088..3865965) 1 NC_012967.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system beta-glucoside-specific transporter subunits IIABC 3865965 bglF 8178770 bglF Escherichia coli B str. REL606 PTS system beta-glucoside-specific transporter subunits IIABC YP_003046782.1 3864088 R 413997 CDS YP_003046783.1 254163675 8177775 complement(3866098..3866934) 1 NC_012967.1 positive regulator of the beta-glucoside operon; transcriptional antiterminator; transcriptional antiterminator BglG 3866934 bglG 8177775 bglG Escherichia coli B str. REL606 transcriptional antiterminator BglG YP_003046783.1 3866098 R 413997 CDS YP_003046784.1 254163676 8177776 complement(3867220..3867945) 1 NC_012967.1 regulates several genes involved in high affinity phosphate uptake; under conditions of high phosphate concentrations downregulates the PHO regulon; transcriptional regulator PhoU 3867945 phoU 8177776 phoU Escherichia coli B str. REL606 transcriptional regulator PhoU YP_003046784.1 3867220 R 413997 CDS YP_003046785.1 254163677 8177777 complement(3867960..3868733) 1 NC_012967.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 3868733 pstB 8177777 pstB Escherichia coli B str. REL606 phosphate transporter ATP-binding protein YP_003046785.1 3867960 R 413997 CDS YP_003046786.1 254163678 8177778 complement(3868916..3869806) 1 NC_012967.1 Part of the ABC transporter complex PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease PtsA 3869806 pstA 8177778 pstA Escherichia coli B str. REL606 phosphate transporter permease PtsA YP_003046786.1 3868916 R 413997 CDS YP_003046787.1 254163679 8179296 complement(3869806..3870765) 1 NC_012967.1 part of the ATP-dependent phosphate uptake system PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease PstC 3870765 pstC 8179296 pstC Escherichia coli B str. REL606 phosphate transporter permease PstC YP_003046787.1 3869806 R 413997 CDS YP_003046788.1 254163680 8177779 complement(3870851..3871891) 1 NC_012967.1 similar to b3728; phosphate ABC transporter periplasmic substrate-binding protein PstS 3871891 pstS 8177779 pstS Escherichia coli B str. REL606 phosphate ABC transporter periplasmic substrate-binding protein PstS YP_003046788.1 3870851 R 413997 CDS YP_003046789.1 254163681 8177780 complement(3872205..3874034) 1 NC_012967.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 3874034 glmS 8177780 glmS Escherichia coli B str. REL606 glucosamine--fructose-6-phosphate aminotransferase YP_003046789.1 3872205 R 413997 CDS YP_003046790.1 254163682 8179297 complement(3874196..3875566) 1 NC_012967.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 3875566 glmU 8179297 glmU Escherichia coli B str. REL606 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase YP_003046790.1 3874196 R 413997 CDS YP_003046791.1 254163683 8177781 complement(3875919..3876338) 1 NC_012967.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon 3876338 atpC 8177781 atpC Escherichia coli B str. REL606 F0F1 ATP synthase subunit epsilon YP_003046791.1 3875919 R 413997 CDS YP_003046792.1 254163684 8179298 complement(3876359..3877741) 1 NC_012967.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta 3877741 atpD 8179298 atpD Escherichia coli B str. REL606 F0F1 ATP synthase subunit beta YP_003046792.1 3876359 R 413997 CDS YP_003046793.1 254163685 8177782 complement(3877768..3878631) 1 NC_012967.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma 3878631 atpG 8177782 atpG Escherichia coli B str. REL606 F0F1 ATP synthase subunit gamma YP_003046793.1 3877768 R 413997 CDS YP_003046794.1 254163686 8177783 complement(3878682..3880223) 1 NC_012967.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha 3880223 atpA 8177783 atpA Escherichia coli B str. REL606 F0F1 ATP synthase subunit alpha YP_003046794.1 3878682 R 413997 CDS YP_003046795.1 254163687 8177784 complement(3880236..3880769) 1 NC_012967.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta 3880769 atpH 8177784 atpH Escherichia coli B str. REL606 F0F1 ATP synthase subunit delta YP_003046795.1 3880236 R 413997 CDS YP_003046796.1 254163688 8177785 complement(3880784..3881254) 1 NC_012967.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B 3881254 atpF 8177785 atpF Escherichia coli B str. REL606 F0F1 ATP synthase subunit B YP_003046796.1 3880784 R 413997 CDS YP_003046797.1 254163689 8178771 complement(3881316..3881555) 1 NC_012967.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C 3881555 atpE 8178771 atpE Escherichia coli B str. REL606 F0F1 ATP synthase subunit C YP_003046797.1 3881316 R 413997 CDS YP_003046798.1 254163690 8177786 complement(3881602..3882417) 1 NC_012967.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A 3882417 atpB 8177786 atpB Escherichia coli B str. REL606 F0F1 ATP synthase subunit A YP_003046798.1 3881602 R 413997 CDS YP_003046799.1 254163691 8177787 complement(3882426..3882806) 1 NC_012967.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation; F0F1 ATP synthase subunit I 3882806 atpI 8177787 atpI Escherichia coli B str. REL606 F0F1 ATP synthase subunit I YP_003046799.1 3882426 R 413997 CDS YP_003046800.1 254163692 8177789 complement(3884105..3885994) 1 NC_012967.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA 3885994 gidA 8177789 gidA Escherichia coli B str. REL606 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA YP_003046800.1 3884105 R 413997 CDS YP_003046801.1 254163693 8178772 complement(3886373..3886816) 1 NC_012967.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin 3886816 mioC 8178772 mioC Escherichia coli B str. REL606 flavodoxin YP_003046801.1 3886373 R 413997 CDS YP_003046802.1 254163694 8177790 complement(3886906..3887364) 1 NC_012967.1 transcriptional repressor of asnA which codes for aspartate-ammonia ligase; DNA-binding transcriptional regulator AsnC 3887364 asnC 8177790 asnC Escherichia coli B str. REL606 DNA-binding transcriptional regulator AsnC YP_003046802.1 3886906 R 413997 CDS YP_003046803.1 254163695 8177791 3887516..3888508 1 NC_012967.1 catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA 3888508 asnA 8177791 asnA Escherichia coli B str. REL606 asparagine synthetase AsnA YP_003046803.1 3887516 D 413997 CDS YP_003046804.1 254163696 8177792 complement(3888513..3889964) 1 NC_012967.1 contains a von Willibrand factor type A domain; stimulates the ATPase activity of RavA; hypothetical protein 3889964 yieM 8177792 yieM Escherichia coli B str. REL606 hypothetical protein YP_003046804.1 3888513 R 413997 CDS YP_003046805.1 254163697 8177793 complement(3889958..3891454) 1 NC_012967.1 interacts with LdcI, lysine decarboxylase; may be active in late log/ early stationary phase; regulatory ATPase RavA 3891454 yieN 8177793 yieN Escherichia coli B str. REL606 regulatory ATPase RavA YP_003046805.1 3889958 R 413997 CDS YP_003046806.1 254163698 8179299 3891677..3893545 1 NC_012967.1 Responsible for the low-affinity transport of potassium into the cell; involved in potassium ion uptake under hyper-osmotic stress at a low pH; potassium transport protein Kup 3893545 trkD 8179299 trkD Escherichia coli B str. REL606 potassium transport protein Kup YP_003046806.1 3891677 D 413997 CDS YP_003046807.1 254163699 8177794 3893601..3894122 1 NC_012967.1 IS150 transposase A 3894122 insJ-5 8177794 insJ-5 Escherichia coli B str. REL606 IS150 transposase A YP_003046807.1 3893601 D 413997 CDS YP_003046808.1 254163700 8177795 3894119..3894970 1 NC_012967.1 IS150 putative transposase 3894970 insK-5 8177795 insK-5 Escherichia coli B str. REL606 IS150 putative transposase YP_003046808.1 3894119 D 413997 CDS YP_003046809.1 254163701 8179300 3895158..3895577 1 NC_012967.1 cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source; D-ribose pyranase 3895577 rbsD 8179300 rbsD Escherichia coli B str. REL606 D-ribose pyranase YP_003046809.1 3895158 D 413997 CDS YP_003046810.1 254163702 8177796 3895585..3897090 1 NC_012967.1 with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain; D-ribose transporter ATP binding protein 3897090 rbsA 8177796 rbsA Escherichia coli B str. REL606 D-ribose transporter ATP binding protein YP_003046810.1 3895585 D 413997 CDS YP_003046811.1 254163703 8179301 3897095..3898060 1 NC_012967.1 functions to transport ribose at high affinity; forms a complex with RbsA2C2B; ribose ABC transporter permease 3898060 rbsC 8179301 rbsC Escherichia coli B str. REL606 ribose ABC transporter permease YP_003046811.1 3897095 D 413997 CDS YP_003046812.1 254163704 8177797 3898085..3898975 1 NC_012967.1 periplasmic substrate-binding component of the ATP-dependent ribose transport system; D-ribose transporter subunit RbsB 3898975 rbsB 8177797 rbsB Escherichia coli B str. REL606 D-ribose transporter subunit RbsB YP_003046812.1 3898085 D 413997 CDS YP_003046813.1 254163705 8177798 3899101..3900030 1 NC_012967.1 catalyzes the formation of D-ribose 5-phosphate from ribose; ribokinase 3900030 rbsK 8177798 rbsK Escherichia coli B str. REL606 ribokinase YP_003046813.1 3899101 D 413997 CDS YP_003046814.1 254163706 8177799 3900034..3901026 1 NC_012967.1 DNA-binding transcriptional repressor of ribose metabolism; transcriptional repressor RbsR 3901026 rbsR 8177799 rbsR Escherichia coli B str. REL606 transcriptional repressor RbsR YP_003046814.1 3900034 D 413997 CDS YP_003046815.1 254163707 8177800 complement(3900992..3902419) 1 NC_012967.1 similar to b3754; putative multidrug or homocysteine efflux system 3902419 yieO 8177800 yieO Escherichia coli B str. REL606 putative multidrug or homocysteine efflux system YP_003046815.1 3900992 R 413997 CDS YP_003046816.1 254163708 8178773 complement(3902442..3903134) 1 NC_012967.1 similar to b3755; putative transcriptional regulator 3903134 yieP 8178773 yieP Escherichia coli B str. REL606 putative transcriptional regulator YP_003046816.1 3902442 R 413997 CDS YP_003046817.1 254163709 8177806 complement(3908928..3909767) 1 NC_012967.1 Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon; transcriptional regulator HdfR 3909767 hdfR 8177806 hdfR Escherichia coli B str. REL606 transcriptional regulator HdfR YP_003046817.1 3908928 R 413997 CDS YP_003046818.1 254163710 8177807 3909886..3910224 1 NC_012967.1 similar to b3764; hypothetical protein 3910224 yifE 8177807 yifE Escherichia coli B str. REL606 hypothetical protein YP_003046818.1 3909886 D 413997 CDS YP_003046819.1 254163711 8177808 complement(3910249..3911799) 1 NC_012967.1 among the AAA+ ATPases, the YifB protease family belongs to the Helix 2 insert clade; unknown function; putative ATP-dependent protease 3911799 yifB 8177808 yifB Escherichia coli B str. REL606 putative ATP-dependent protease YP_003046819.1 3910249 R 413997 CDS YP_003046820.1 254163712 8179302 3912122..3912220 1 NC_012967.1 similar to b3766; ilvG operon leader peptide 3912220 ilvL 8179302 ilvL Escherichia coli B str. REL606 ilvG operon leader peptide YP_003046820.1 3912122 D 413997 CDS YP_003046821.1 254163713 8177809 3912360..3914006 1 NC_012967.1 catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; acetolactate synthase 2 catalytic subunit 3914006 ilvG 8177809 ilvG Escherichia coli B str. REL606 acetolactate synthase 2 catalytic subunit YP_003046821.1 3912360 D 413997 CDS YP_003046822.1 254163714 8177810 3914003..3914266 1 NC_012967.1 similar to b3769; acetolactate synthase 2 regulatory subunit 3914266 ilvM 8177810 ilvM Escherichia coli B str. REL606 acetolactate synthase 2 regulatory subunit YP_003046822.1 3914003 D 413997 CDS YP_003046823.1 254163715 8179303 3914286..3915215 1 NC_012967.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 3915215 ilvE 8179303 ilvE Escherichia coli B str. REL606 branched-chain amino acid aminotransferase YP_003046823.1 3914286 D 413997 CDS YP_003046824.1 254163716 8177811 3915280..3917130 1 NC_012967.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 3917130 ilvD 8177811 ilvD Escherichia coli B str. REL606 dihydroxy-acid dehydratase YP_003046824.1 3915280 D 413997 CDS YP_003046825.1 254163717 8177812 3917133..3918677 1 NC_012967.1 threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway; threonine dehydratase 3918677 ilvA 8177812 ilvA Escherichia coli B str. REL606 threonine dehydratase YP_003046825.1 3917133 D 413997 CDS YP_003046826.1 254163718 8177813 complement(3918729..3919622) 1 NC_012967.1 participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate; DNA-binding transcriptional regulator IlvY 3919622 ilvY 8177813 ilvY Escherichia coli B str. REL606 DNA-binding transcriptional regulator IlvY YP_003046826.1 3918729 R 413997 CDS YP_003046827.1 254163719 8177814 3919772..3921247 1 NC_012967.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 3921247 ilvC 8177814 ilvC Escherichia coli B str. REL606 ketol-acid reductoisomerase YP_003046827.1 3919772 D 413997 CDS YP_003046828.1 254163720 8177815 complement(3921334..3921615) 1 NC_012967.1 similar to b3775; peptidyl-prolyl cis-trans isomerase C (rotamase C) 3921615 ppiC 8177815 ppiC Escherichia coli B str. REL606 peptidyl-prolyl cis-trans isomerase C (rotamase C) YP_003046828.1 3921334 R 413997 CDS YP_003046829.1 254163721 8177816 complement(3921814..3922089) 1 NC_012967.1 similar to b3776; hypothetical protein 3922089 8177816 ECB_03654 Escherichia coli B str. REL606 hypothetical protein YP_003046829.1 3921814 R 413997 CDS YP_003046830.1 254163722 8177818 3922479..3924500 1 NC_012967.1 single-stranded DNA-dependent ATPase; initiates unwinding at a nick in the DNA; involved in DNA replication; ATP-dependent DNA helicase Rep 3924500 rep 8177818 rep Escherichia coli B str. REL606 ATP-dependent DNA helicase Rep YP_003046830.1 3922479 D 413997 CDS YP_003046831.1 254163723 8178775 complement(3924547..3926031) 1 NC_012967.1 catalyzes the conversion of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) to guanosine 5'-diphosphate,3'-diphosphate (ppGpp); pppGpp and ppGpp control the stringent response during amino acid starvation; guanosine pentaphosphate phosphohydrolase 3926031 gppA 8178775 gppA Escherichia coli B str. REL606 guanosine pentaphosphate phosphohydrolase YP_003046831.1 3924547 R 413997 CDS YP_003046832.1 254163724 8179304 complement(3926165..3927430) 1 NC_012967.1 enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation; ATP-dependent RNA helicase RhlB 3927430 rhlB 8179304 rhlB Escherichia coli B str. REL606 ATP-dependent RNA helicase RhlB YP_003046832.1 3926165 R 413997 CDS YP_003046833.1 254163725 8177819 3927561..3927890 1 NC_012967.1 similar to b3781; thioredoxin 3927890 trxA 8177819 trxA Escherichia coli B str. REL606 thioredoxin YP_003046833.1 3927561 D 413997 CDS YP_003046834.1 254163726 8177820 3928031..3928132 1 NC_012967.1 similar to b3782; putative rho operon leader peptide 3928132 rhoL 8177820 rhoL Escherichia coli B str. REL606 putative rho operon leader peptide YP_003046834.1 3928031 D 413997 CDS YP_003046835.1 254163727 8177821 3928217..3929476 1 NC_012967.1 similar to b3783; transcription termination factor Rho 3929476 rho 8177821 rho Escherichia coli B str. REL606 transcription termination factor Rho YP_003046835.1 3928217 D 413997 CDS YP_003046836.1 254163728 8179305 3929716..3930819 1 NC_012967.1 similar to b3784; UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase 3930819 rfe 8179305 rfe Escherichia coli B str. REL606 UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase YP_003046836.1 3929716 D 413997 CDS YP_003046837.1 254163729 8177822 3930831..3931877 1 NC_012967.1 Enterobacterial Common Antigen (ECA) polysaccharide chain length modulation protein; lipopolysaccharide biosynthesis protein WzzE 3931877 wzzE 8177822 wzzE Escherichia coli B str. REL606 lipopolysaccharide biosynthesis protein WzzE YP_003046837.1 3930831 D 413997 CDS YP_003046838.1 254163730 8177823 3931933..3933063 1 NC_012967.1 similar to b3786; UDP-N-acetyl glucosamine-2-epimerase 3933063 wecB 8177823 wecB Escherichia coli B str. REL606 UDP-N-acetyl glucosamine-2-epimerase YP_003046838.1 3931933 D 413997 CDS YP_003046839.1 254163731 8177824 3933060..3934322 1 NC_012967.1 catalyzes the oxidation of UDP-N-acetyl-D-mannosamine to UDP-N-acetylmannosaminuronic acid; UDP-N-acetyl-D-mannosamine dehydrogenase 3934322 wecC 8177824 wecC Escherichia coli B str. REL606 UDP-N-acetyl-D-mannosamine dehydrogenase YP_003046839.1 3933060 D 413997 CDS YP_003046840.1 254163732 8177825 3934322..3935389 1 NC_012967.1 similar to b3788; dTDP-glucose 4,6-dehydratase 3935389 rffG 8177825 rffG Escherichia coli B str. REL606 dTDP-glucose 4,6-dehydratase YP_003046840.1 3934322 D 413997 CDS YP_003046841.1 254163733 8179306 3935408..3936289 1 NC_012967.1 similar to b3789; glucose-1-phosphate thymidylyltransferase 3936289 rffH 8179306 rffH Escherichia coli B str. REL606 glucose-1-phosphate thymidylyltransferase YP_003046841.1 3935408 D 413997 CDS YP_003046842.1 254163734 8179307 3936396..3936941 1 NC_012967.1 similar to b3790; TDP-fucosamine acetyltransferase 3936941 wecD 8179307 wecD Escherichia coli B str. REL606 TDP-fucosamine acetyltransferase YP_003046842.1 3936396 D 413997 CDS YP_003046843.1 254163735 8177826 3936946..3938076 1 NC_012967.1 catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis; TDP-4-oxo-6-deoxy-D-glucose transaminase 3938076 wecE 8177826 wecE Escherichia coli B str. REL606 TDP-4-oxo-6-deoxy-D-glucose transaminase YP_003046843.1 3936946 D 413997 CDS YP_003046844.1 254163736 8177827 3938078..3939328 1 NC_012967.1 similar to b3792; O-antigen translocase 3939328 wzxE 8177827 wzxE Escherichia coli B str. REL606 O-antigen translocase YP_003046844.1 3938078 D 413997 CDS YP_003046845.1 254163737 8178776 3939325..3940404 1 NC_012967.1 catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis; 4-alpha-L-fucosyltransferase 3940404 rffT 8178776 rffT Escherichia coli B str. REL606 4-alpha-L-fucosyltransferase YP_003046845.1 3939325 D 413997 CDS YP_003046846.1 254163738 8178777 3940401..3941753 1 NC_012967.1 enterobacterial common antigen polymerase; putative common antigen polymerase 3941753 wecF 8178777 wecF Escherichia coli B str. REL606 putative common antigen polymerase YP_003046846.1 3940401 D 413997 CDS YP_003046847.1 254163739 8177828 3941756..3942496 1 NC_012967.1 similar to b3794; putative UDP-N-acetyl-D-mannosaminuronic acid transferase 3942496 wecG 8177828 wecG Escherichia coli B str. REL606 putative UDP-N-acetyl-D-mannosaminuronic acid transferase YP_003046847.1 3941756 D 413997 CDS YP_003046848.1 254163740 8177829 3942687..3944072 1 NC_012967.1 uncharacterized member of the amino acid-polyamine-organocation (APC) superfamily of amino acid transporters; unknown function; putative transport protein YifK 3944072 yifK 8177829 yifK Escherichia coli B str. REL606 putative transport protein YifK YP_003046848.1 3942687 D 413997 CDS YP_003046849.1 254163741 8177833 3944758..3945993 1 NC_012967.1 similar to b3800; putative regulator of arylsulfatase activity 3945993 aslB 8177833 aslB Escherichia coli B str. REL606 putative regulator of arylsulfatase activity YP_003046849.1 3944758 D 413997 CDS YP_003046850.1 254163742 8177834 complement(3946151..3947806) 1 NC_012967.1 similar to b3801; acrylsulfatase-like enzyme 3947806 aslA 8177834 aslA Escherichia coli B str. REL606 acrylsulfatase-like enzyme YP_003046850.1 3946151 R 413997 CDS YP_003046851.1 254163743 8178779 complement(3948492..3949688) 1 NC_012967.1 similar to b3802; putative protoheme IX biogenesis protein 3949688 hemY 8178779 hemY Escherichia coli B str. REL606 putative protoheme IX biogenesis protein YP_003046851.1 3948492 R 413997 CDS YP_003046852.1 254163744 8179308 complement(3949691..3950896) 1 NC_012967.1 similar to b3803; putative uroporphyrinogen III C-methyltransferase 3950896 hemX 8179308 hemX Escherichia coli B str. REL606 putative uroporphyrinogen III C-methyltransferase YP_003046852.1 3949691 R 413997 CDS YP_003046853.1 254163745 8177835 complement(3950918..3951658) 1 NC_012967.1 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis; uroporphyrinogen-III synthase 3951658 hemD 8177835 hemD Escherichia coli B str. REL606 uroporphyrinogen-III synthase YP_003046853.1 3950918 R 413997 CDS YP_003046854.1 254163746 8177836 complement(3951655..3952596) 1 NC_012967.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 3952596 hemC 8177836 hemC Escherichia coli B str. REL606 porphobilinogen deaminase YP_003046854.1 3951655 R 413997 CDS YP_003046855.1 254163747 8177837 3952983..3955529 1 NC_012967.1 catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP; adenylate cyclase 3955529 cyaA 8177837 cyaA Escherichia coli B str. REL606 adenylate cyclase YP_003046855.1 3952983 D 413997 CDS YP_003046856.1 254163748 8177838 complement(3955569..3955889) 1 NC_012967.1 defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly; frataxin-like protein 3955889 cyaY 8177838 cyaY Escherichia coli B str. REL606 frataxin-like protein YP_003046856.1 3955569 R 413997 CDS YP_003046857.1 254163749 8177839 3955680..3955907 1 NC_012967.1 similar to b3808; hypothetical protein 3955907 yzcX 8177839 yzcX Escherichia coli B str. REL606 hypothetical protein YP_003046857.1 3955680 D 413997 CDS YP_003046858.1 254163750 8177840 3956359..3956562 1 NC_012967.1 similar to b4558; putative lipoprotein 3956562 yifL 8177840 yifL Escherichia coli B str. REL606 putative lipoprotein YP_003046858.1 3956359 D 413997 CDS YP_003046859.1 254163751 8177841 3956599..3957423 1 NC_012967.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 3957423 dapF 8177841 dapF Escherichia coli B str. REL606 diaminopimelate epimerase YP_003046859.1 3956599 D 413997 CDS YP_003046860.1 254163752 8177842 3957420..3958127 1 NC_012967.1 similar to b3810; hypothetical protein 3958127 yigA 8177842 yigA Escherichia coli B str. REL606 hypothetical protein YP_003046860.1 3957420 D 413997 CDS YP_003046861.1 254163753 8177843 3958124..3959020 1 NC_012967.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC 3959020 xerC 8177843 xerC Escherichia coli B str. REL606 site-specific tyrosine recombinase XerC YP_003046861.1 3958124 D 413997 CDS YP_003046862.1 254163754 8178780 3959020..3959736 1 NC_012967.1 YigB; member of the haloacid dehalogenase (HAD)-like hydrolases superfamily of protein; unknown function; flavin mononucleotide phosphatase 3959736 yigB 8178780 yigB Escherichia coli B str. REL606 flavin mononucleotide phosphatase YP_003046862.1 3959020 D 413997 CDS YP_003046863.1 254163755 8177844 3959820..3961982 1 NC_012967.1 unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair.; DNA-dependent helicase II 3961982 uvrD 8177844 uvrD Escherichia coli B str. REL606 DNA-dependent helicase II YP_003046863.1 3959820 D 413997 CDS YP_003046864.1 254163756 8177845 complement(3962037..3962939) 1 NC_012967.1 hypothetical protein 3962939 8177845 ECB_03690 Escherichia coli B str. REL606 hypothetical protein YP_003046864.1 3962037 R 413997 CDS YP_003046865.1 254163757 8177846 complement(3963022..3963786) 1 NC_012967.1 similar to b4482; hypothetical protein 3963786 yigE 8177846 yigE Escherichia coli B str. REL606 hypothetical protein YP_003046865.1 3963022 R 413997 CDS YP_003046866.1 254163758 8178781 3964156..3965106 1 NC_012967.1 responsible for the influx of magnesium ions; magnesium/nickel/cobalt transporter CorA 3965106 corA 8178781 corA Escherichia coli B str. REL606 magnesium/nickel/cobalt transporter CorA YP_003046866.1 3964156 D 413997 CDS YP_003046867.1 254163759 8177847 complement(3965148..3965570) 1 NC_012967.1 hypothetical protein 3965570 8177847 ECB_03693 Escherichia coli B str. REL606 hypothetical protein YP_003046867.1 3965148 R 413997 CDS YP_003046868.1 254163760 8177848 complement(3965636..3966484) 1 NC_012967.1 hypothetical protein 3966484 8177848 ECB_03694 Escherichia coli B str. REL606 hypothetical protein YP_003046868.1 3965636 R 413997 CDS YP_003046869.1 254163761 8177849 3966637..3966813 1 NC_012967.1 Magnesium and cobalt transport protein corA 3966813 8177849 ECB_03695 Escherichia coli B str. REL606 Magnesium and cobalt transport protein corA YP_003046869.1 3966637 D 413997 CDS YP_003046870.1 254163762 8177850 complement(3966854..3967234) 1 NC_012967.1 similar to b3817; inner membrane protein 3967234 yigF 8177850 yigF Escherichia coli B str. REL606 inner membrane protein YP_003046870.1 3966854 R 413997 CDS YP_003046871.1 254163763 8178782 complement(3967248..3967454) 1 NC_012967.1 similar to b3818; putative inner membrane protein 3967454 yigG 8178782 yigG Escherichia coli B str. REL606 putative inner membrane protein YP_003046871.1 3967248 R 413997 CDS YP_003046872.1 254163764 8177851 complement(3967723..3968613) 1 NC_012967.1 similar to b3819; putative chloramphenical resistance permease 3968613 rarD 8177851 rarD Escherichia coli B str. REL606 putative chloramphenical resistance permease YP_003046872.1 3967723 R 413997 CDS YP_003046873.1 254163765 8179309 complement(3968665..3969132) 1 NC_012967.1 similar to b3820; hypothetical protein 3969132 yigI 8179309 yigI Escherichia coli B str. REL606 hypothetical protein YP_003046873.1 3968665 R 413997 CDS YP_003046874.1 254163766 8179310 3969297..3970166 1 NC_012967.1 catalyzes the hydrolysis of phosphatidylcholine; phospholipase A 3970166 pldA 8179310 pldA Escherichia coli B str. REL606 phospholipase A YP_003046874.1 3969297 D 413997 CDS YP_003046875.1 254163767 8177852 3970285..3972120 1 NC_012967.1 functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway; ATP-dependent DNA helicase RecQ 3972120 recQ 8177852 recQ Escherichia coli B str. REL606 ATP-dependent DNA helicase RecQ YP_003046875.1 3970285 D 413997 CDS YP_003046876.1 254163768 8177853 3972184..3972804 1 NC_012967.1 similar to b3823; threonine efflux system 3972804 rhtC 8177853 rhtC Escherichia coli B str. REL606 threonine efflux system YP_003046876.1 3972184 D 413997 CDS YP_003046877.1 254163769 8177854 complement(3972866..3973486) 1 NC_012967.1 similar to b3824; homoserine/homoserine lactone efflux protein 3973486 rhtB 8177854 rhtB Escherichia coli B str. REL606 homoserine/homoserine lactone efflux protein YP_003046877.1 3972866 R 413997 CDS YP_003046878.1 254163770 8177855 3973597..3974619 1 NC_012967.1 lecithinase B; catalyzes the conversion of 1-lysophosphatidylcholine to glycerophosphocholine; can also hydrolyze 2-acyl glycerophosphoethanolamine and other substrates; lysophospholipase L2 3974619 pldB 8177855 pldB Escherichia coli B str. REL606 lysophospholipase L2 YP_003046878.1 3973597 D 413997 CDS YP_003046879.1 254163771 8177856 3974627..3975427 1 NC_012967.1 purine and pyrimidine nucleotides are secondary substrates; yigL expression is regulated by heat shock, osmotic shock and starvation of glucose, phosphate or ammonium; putative sugar phosphatase 3975427 yigL 8177856 yigL Escherichia coli B str. REL606 putative sugar phosphatase YP_003046879.1 3974627 D 413997 CDS YP_003046880.1 254163772 8177857 3975503..3976402 1 NC_012967.1 similar to b3827; putative inner membrane protein 3976402 yigM 8177857 yigM Escherichia coli B str. REL606 putative inner membrane protein YP_003046880.1 3975503 D 413997 CDS YP_003046881.1 254163773 8177858 complement(3976290..3977243) 1 NC_012967.1 similar to b3828; DNA-binding transcriptional activator, homocysteine-binding 3977243 metR 8177858 metR Escherichia coli B str. REL606 DNA-binding transcriptional activator, homocysteine-binding YP_003046881.1 3976290 R 413997 CDS YP_003046882.1 254163774 8177859 3977480..3979741 1 NC_012967.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 3979741 metE 8177859 metE Escherichia coli B str. REL606 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase YP_003046882.1 3977480 D 413997 CDS YP_003046883.1 254163775 8177860 complement(3979835..3980731) 1 NC_012967.1 hypothetical protein 3980731 8177860 ECB_03709 Escherichia coli B str. REL606 hypothetical protein YP_003046883.1 3979835 R 413997 CDS YP_003046884.1 254163776 8177861 complement(3980809..3982032) 1 NC_012967.1 putative permease 3982032 8177861 ECB_03710 Escherichia coli B str. REL606 putative permease YP_003046884.1 3980809 R 413997 CDS YP_003046885.1 254163777 8177862 complement(3982058..3982411) 1 NC_012967.1 hypothetical protein 3982411 8177862 ECB_03711 Escherichia coli B str. REL606 hypothetical protein YP_003046885.1 3982058 R 413997 CDS YP_003046886.1 254163778 8178783 complement(3982464..3983504) 1 NC_012967.1 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 3983504 8178783 ECB_03712 Escherichia coli B str. REL606 carbamate kinase YP_003046886.1 3982464 R 413997 CDS YP_003046887.1 254163779 8177863 complement(3983413..3984888) 1 NC_012967.1 hypothetical protein 3984888 8177863 ECB_03713 Escherichia coli B str. REL606 hypothetical protein YP_003046887.1 3983413 R 413997 CDS YP_003046888.1 254163780 8178784 complement(3984834..3986393) 1 NC_012967.1 hypothetical protein 3986393 8178784 ECB_03714 Escherichia coli B str. REL606 hypothetical protein YP_003046888.1 3984834 R 413997 CDS YP_003046889.1 254163781 8177864 complement(3986488..3987348) 1 NC_012967.1 hypothetical protein 3987348 8177864 ECB_03715 Escherichia coli B str. REL606 hypothetical protein YP_003046889.1 3986488 R 413997 CDS YP_003046890.1 254163782 8177865 complement(3987354..3988022) 1 NC_012967.1 hypothetical protein 3988022 8177865 ECB_03716 Escherichia coli B str. REL606 hypothetical protein YP_003046890.1 3987354 R 413997 CDS YP_003046891.1 254163783 8177866 complement(3988279..3989088) 1 NC_012967.1 similar to b3830; putative hydrolase 3989088 ysgA 8177866 ysgA Escherichia coli B str. REL606 putative hydrolase YP_003046891.1 3988279 R 413997 CDS YP_003046892.1 254163784 8177867 3989350..3990114 1 NC_012967.1 catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway; uridine phosphorylase 3990114 udp 8177867 udp Escherichia coli B str. REL606 uridine phosphorylase YP_003046892.1 3989350 D 413997 CDS YP_003046893.1 254163785 8179311 complement(3990148..3991638) 1 NC_012967.1 hypothetical protein 3991638 8179311 ECB_03719 Escherichia coli B str. REL606 hypothetical protein YP_003046893.1 3990148 R 413997 CDS YP_003046894.1 254163786 8179312 complement(3991651..3992160) 1 NC_012967.1 hypothetical protein 3992160 8179312 ECB_03720 Escherichia coli B str. REL606 hypothetical protein YP_003046894.1 3991651 R 413997 CDS YP_003046895.1 254163787 8177868 complement(3992174..3993148) 1 NC_012967.1 hypothetical protein 3993148 8177868 ECB_03721 Escherichia coli B str. REL606 hypothetical protein YP_003046895.1 3992174 R 413997 CDS YP_003046896.1 254163788 8177869 complement(3993173..3993802) 1 NC_012967.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-galactonate 6-phosphate; functions in galactonate metabolism; 2-dehydro-3-deoxy-6-phosphogalactonate aldolase 3993802 8177869 ECB_03722 Escherichia coli B str. REL606 2-dehydro-3-deoxy-6-phosphogalactonate aldolase YP_003046896.1 3993173 R 413997 CDS YP_003046897.1 254163789 8179313 complement(3993792..3994796) 1 NC_012967.1 hypothetical protein 3994796 8179313 ECB_03723 Escherichia coli B str. REL606 hypothetical protein YP_003046897.1 3993792 R 413997 CDS YP_003046898.1 254163790 8179314 complement(3994820..3995587) 1 NC_012967.1 putative transcriptional regulator 3995587 8179314 ECB_03724 Escherichia coli B str. REL606 putative transcriptional regulator YP_003046898.1 3994820 R 413997 CDS YP_003046899.1 254163791 8177870 3995804..3997231 1 NC_012967.1 YigN; nuclease that may cleave DNA structures arising during the recombination of short-inverted repeats and thereby prevents the inversion of the internal sequence; transcription is induced by DNA-damaging agents such as nalidixic acid or mitomycin C in a LexA-dependent manner; DNA recombination protein RmuC 3997231 yigN 8177870 yigN Escherichia coli B str. REL606 DNA recombination protein RmuC YP_003046899.1 3995804 D 413997 CDS YP_003046900.1 254163792 8179315 3997326..3998081 1 NC_012967.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase 3998081 ubiE 8179315 ubiE Escherichia coli B str. REL606 ubiquinone/menaquinone biosynthesis methyltransferase YP_003046900.1 3997326 D 413997 CDS YP_003046901.1 254163793 8177871 3998095..3998700 1 NC_012967.1 similar to b3834; hypothetical protein 3998700 yigP 8177871 yigP Escherichia coli B str. REL606 hypothetical protein YP_003046901.1 3998095 D 413997 CDS YP_003046902.1 254163794 8179316 3998697..4000337 1 NC_012967.1 an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions; putative ubiquinone biosynthesis protein UbiB 4000337 ubiB 8179316 ubiB Escherichia coli B str. REL606 putative ubiquinone biosynthesis protein UbiB YP_003046902.1 3998697 D 413997 CDS YP_003046903.1 254163795 8177872 4000416..4000685 1 NC_012967.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase protein A 4000685 tatA 8177872 tatA Escherichia coli B str. REL606 twin arginine translocase protein A YP_003046903.1 4000416 D 413997 CDS YP_003046904.1 254163796 8177873 4000689..4001204 1 NC_012967.1 mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase 4001204 tatB 8177873 tatB Escherichia coli B str. REL606 sec-independent translocase YP_003046904.1 4000689 D 413997 CDS YP_003046905.1 254163797 8177874 4001207..4001983 1 NC_012967.1 with TatABE forms the twin-arginine translocation complex which is involved in the transport of proteins across the cytoplasmic membrane; twin-arginine protein translocation system subunit TatC 4001983 tatC 8177874 tatC Escherichia coli B str. REL606 twin-arginine protein translocation system subunit TatC YP_003046905.1 4001207 D 413997 CDS YP_003046906.1 254163798 8177875 4002025..4002807 1 NC_012967.1 magnesium dependent; not involved in the Sec-independent protein export system; DNase TatD 4002807 tatD 8177875 tatD Escherichia coli B str. REL606 DNase TatD YP_003046906.1 4002025 D 413997 CDS YP_003046907.1 254163799 8177876 complement(4002804..4003292) 1 NC_012967.1 similar to b3842; transcriptional activator RfaH 4003292 rfaH 8177876 rfaH Escherichia coli B str. REL606 transcriptional activator RfaH YP_003046907.1 4002804 R 413997 CDS YP_003046908.1 254163800 8177877 4003459..4004952 1 NC_012967.1 catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol; 3-octaprenyl-4-hydroxybenzoate decarboxylase 4004952 ubiD 8177877 ubiD Escherichia coli B str. REL606 3-octaprenyl-4-hydroxybenzoate decarboxylase YP_003046908.1 4003459 D 413997 CDS YP_003046909.1 254163801 8177878 4004998..4005699 1 NC_012967.1 NAD(P)H-flavin reductase; catalyzes the reversible oxidation/reduction of NAD(P) and flavine mononucleotide; in Salmonella and E. coli this protein also reduces aquacob(III)alamin to cob(II)alamin; FMN reductase 4005699 fre 8177878 fre Escherichia coli B str. REL606 FMN reductase YP_003046909.1 4004998 D 413997 CDS YP_003046910.1 254163802 8178785 complement(4005982..4007145) 1 NC_012967.1 FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; 3-ketoacyl-CoA thiolase 4007145 fadA 8178785 fadA Escherichia coli B str. REL606 3-ketoacyl-CoA thiolase YP_003046910.1 4005982 R 413997 CDS YP_003046911.1 254163803 8177879 complement(4007155..4009344) 1 NC_012967.1 includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; multifunctional fatty acid oxidation complex subunit alpha 4009344 fadB 8177879 fadB Escherichia coli B str. REL606 multifunctional fatty acid oxidation complex subunit alpha YP_003046911.1 4007155 R 413997 CDS YP_003046912.1 254163804 8178786 4009534..4010865 1 NC_012967.1 catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters; proline dipeptidase 4010865 pepQ 8178786 pepQ Escherichia coli B str. REL606 proline dipeptidase YP_003046912.1 4009534 D 413997 CDS YP_003046913.1 254163805 8177880 4010865..4011479 1 NC_012967.1 similar to b3848; hypothetical protein 4011479 yigZ 8177880 yigZ Escherichia coli B str. REL606 hypothetical protein YP_003046913.1 4010865 D 413997 CDS YP_003046914.1 254163806 8177881 4011518..4012969 1 NC_012967.1 similar to b3849; potassium transporter 4012969 trkH 8177881 trkH Escherichia coli B str. REL606 potassium transporter YP_003046914.1 4011518 D 413997 CDS YP_003046915.1 254163807 8178787 4012981..4013526 1 NC_012967.1 catalyzes the oxidation of protoporphyrinogen IX to form protoporphyrin IX; protoporphyrinogen oxidase 4013526 hemG 8178787 hemG Escherichia coli B str. REL606 protoporphyrinogen oxidase YP_003046915.1 4012981 D 413997 CDS YP_003046916.1 254163808 8177886 complement(4019203..4019715) 1 NC_012967.1 in Escherichia coli the MobB protein is not essential but has been found to interact with multiple proteins involved in the molybdopterin guanine dinucleotide cofactor biosynthesis pathway; molybdopterin-guanine dinucleotide biosynthesis protein B 4019715 mobB 8177886 mobB Escherichia coli B str. REL606 molybdopterin-guanine dinucleotide biosynthesis protein B YP_003046916.1 4019203 R 413997 CDS YP_003046917.1 254163809 8179318 complement(4019712..4020296) 1 NC_012967.1 in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis; molybdopterin-guanine dinucleotide biosynthesis protein MobA 4020296 mobA 8179318 mobA Escherichia coli B str. REL606 molybdopterin-guanine dinucleotide biosynthesis protein MobA YP_003046917.1 4019712 R 413997 CDS YP_003046918.1 254163810 8177887 4020366..4020635 1 NC_012967.1 similar to b3858; hypothetical protein 4020635 yihD 8177887 yihD Escherichia coli B str. REL606 hypothetical protein YP_003046918.1 4020366 D 413997 CDS YP_003046919.1 254163811 8177888 4020712..4021698 1 NC_012967.1 catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages; serine/threonine protein kinase 4021698 yihE 8177888 yihE Escherichia coli B str. REL606 serine/threonine protein kinase YP_003046919.1 4020712 D 413997 CDS YP_003046920.1 254163812 8177889 4021715..4022341 1 NC_012967.1 similar to b3860; periplasmic protein disulfide isomerase I 4022341 dsbA 8177889 dsbA Escherichia coli B str. REL606 periplasmic protein disulfide isomerase I YP_003046920.1 4021715 D 413997 CDS YP_003046921.1 254163813 8177890 4022496..4023926 1 NC_012967.1 similar to b3861; hypothetical protein 4023926 yihF 8177890 yihF Escherichia coli B str. REL606 hypothetical protein YP_003046921.1 4022496 D 413997 CDS YP_003046922.1 254163814 8177891 complement(4023967..4024899) 1 NC_012967.1 similar to b3862; putative acyltransferase 4024899 yihG 8177891 yihG Escherichia coli B str. REL606 putative acyltransferase YP_003046922.1 4023967 R 413997 CDS YP_003046923.1 254163815 8177892 4025263..4028049 1 NC_012967.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 4028049 polA 8177892 polA Escherichia coli B str. REL606 DNA polymerase I YP_003046923.1 4025263 D 413997 CDS YP_003046924.1 254163816 8177893 complement(4028430..4029026) 1 NC_012967.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 4029026 engB 8177893 engB Escherichia coli B str. REL606 ribosome biogenesis GTP-binding protein YsxC YP_003046924.1 4028430 R 413997 CDS YP_003046925.1 254163817 8178788 4029644..4030153 1 NC_012967.1 similar to b3866; hypothetical protein 4030153 yihI 8178788 yihI Escherichia coli B str. REL606 hypothetical protein YP_003046925.1 4029644 D 413997 CDS YP_003046926.1 254163818 8177894 4030342..4031715 1 NC_012967.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 4031715 hemN 8177894 hemN Escherichia coli B str. REL606 coproporphyrinogen III oxidase YP_003046926.1 4030342 D 413997 CDS YP_003046927.1 254163819 8178789 complement(4032127..4033536) 1 NC_012967.1 response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes; interacts with sigma-54; nitrogen regulation protein NR(I) 4033536 glnG 8178789 glnG Escherichia coli B str. REL606 nitrogen regulation protein NR(I) YP_003046927.1 4032127 R 413997 CDS YP_003046928.1 254163820 8177895 complement(4033548..4034597) 1 NC_012967.1 sensory histidine kinase in two-component regulatory system with GlnG; acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC by phosphorylation/dephosphorylation; nitrogen regulation protein NR(II) 4034597 glnL 8177895 glnL Escherichia coli B str. REL606 nitrogen regulation protein NR(II) YP_003046928.1 4033548 R 413997 CDS YP_003046929.1 254163821 8177896 complement(4034883..4036292) 1 NC_012967.1 forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme; glutamine synthetase 4036292 glnA 8177896 glnA Escherichia coli B str. REL606 glutamine synthetase YP_003046929.1 4034883 R 413997 CDS YP_003046930.1 254163822 8178790 4036665..4038488 1 NC_012967.1 similar to b3871; GTP-binding protein 4038488 bipA 8178790 bipA Escherichia coli B str. REL606 GTP-binding protein YP_003046930.1 4036665 D 413997 CDS YP_003046931.1 254163823 8177897 4038705..4039415 1 NC_012967.1 similar to b3872; putative DNA-binding transcriptional regulator 4039415 yihL 8177897 yihL Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003046931.1 4038705 D 413997 CDS YP_003046932.1 254163824 8179319 4039423..4040403 1 NC_012967.1 similar to b3873; putative sugar phosphate isomerase 4040403 yihM 8179319 yihM Escherichia coli B str. REL606 putative sugar phosphate isomerase YP_003046932.1 4039423 D 413997 CDS YP_003046933.1 254163825 8177898 4040505..4041770 1 NC_012967.1 similar to b3874; putative transporter 4041770 yihN 8177898 yihN Escherichia coli B str. REL606 putative transporter YP_003046933.1 4040505 D 413997 CDS YP_003046934.1 254163826 8177899 complement(4041861..4042553) 1 NC_012967.1 porin involved in the transport of small molecular weight solutes (up to 600 Daltons) across the cell wall; specific substrate still unknown; outer membrane porin L 4042553 ompL 8177899 ompL Escherichia coli B str. REL606 outer membrane porin L YP_003046934.1 4041861 R 413997 CDS YP_003046935.1 254163827 8177900 complement(4042620..4044023) 1 NC_012967.1 similar to b3876; putative transporter 4044023 yihO 8177900 yihO Escherichia coli B str. REL606 putative transporter YP_003046935.1 4042620 R 413997 CDS YP_003046936.1 254163828 8177901 complement(4044063..4045469) 1 NC_012967.1 similar to b3877; putative transporter 4045469 yihP 8177901 yihP Escherichia coli B str. REL606 putative transporter YP_003046936.1 4044063 R 413997 CDS YP_003046937.1 254163829 8179320 complement(4045494..4047497) 1 NC_012967.1 similar to b3878; alpha-glucosidase 4047497 yihQ 8179320 yihQ Escherichia coli B str. REL606 alpha-glucosidase YP_003046937.1 4045494 R 413997 CDS YP_003046938.1 254163830 8177902 complement(4047622..4048548) 1 NC_012967.1 similar to b3879; putative aldose-1-epimerase 4048548 yihR 8177902 yihR Escherichia coli B str. REL606 putative aldose-1-epimerase YP_003046938.1 4047622 R 413997 CDS YP_003046939.1 254163831 8177903 complement(4048662..4049903) 1 NC_012967.1 similar to b3880; putative glucosamine isomerase 4049903 yihS 8177903 yihS Escherichia coli B str. REL606 putative glucosamine isomerase YP_003046939.1 4048662 R 413997 CDS YP_003046940.1 254163832 8177904 complement(4049920..4050798) 1 NC_012967.1 similar to b3881; putative aldolase 4050798 yihT 8177904 yihT Escherichia coli B str. REL606 putative aldolase YP_003046940.1 4049920 R 413997 CDS YP_003046941.1 254163833 8177905 complement(4050822..4051718) 1 NC_012967.1 similar to b3882; putative oxidoreductase with NAD(P)-binding Rossmann-fold domain 4051718 yihU 8177905 yihU Escherichia coli B str. REL606 putative oxidoreductase with NAD(P)-binding Rossmann-fold domain YP_003046941.1 4050822 R 413997 CDS YP_003046942.1 254163834 8177906 4051886..4052782 1 NC_012967.1 similar to b3883; putative sugar kinase 4052782 yihV 8177906 yihV Escherichia coli B str. REL606 putative sugar kinase YP_003046942.1 4051886 D 413997 CDS YP_003046943.1 254163835 8177907 4052816..4053601 1 NC_012967.1 similar to b3884; putative DNA-binding transcriptional regulator 4053601 yihW 8177907 yihW Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003046943.1 4052816 D 413997 CDS YP_003046944.1 254163836 8177908 4053700..4054299 1 NC_012967.1 similar to b3885; phosphatase 4054299 yihX 8177908 yihX Escherichia coli B str. REL606 phosphatase YP_003046944.1 4053700 D 413997 CDS YP_003046945.1 254163837 8178791 4054293..4055165 1 NC_012967.1 RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease; ribonuclease BN 4055165 rbn 8178791 rbn Escherichia coli B str. REL606 ribonuclease BN YP_003046945.1 4054293 D 413997 CDS YP_003046946.1 254163838 8177909 4055162..4055599 1 NC_012967.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 4055599 dtd 8177909 dtd Escherichia coli B str. REL606 D-tyrosyl-tRNA(Tyr) deacylase YP_003046946.1 4055162 D 413997 CDS YP_003046947.1 254163839 8177910 4057438..4057656 1 NC_012967.1 similar to b3889; putative transcriptional regulator 4057656 yiiE 8177910 yiiE Escherichia coli B str. REL606 putative transcriptional regulator YP_003046947.1 4057438 D 413997 CDS YP_003046948.1 254163840 8177911 4057898..4058116 1 NC_012967.1 similar to b3890; hypothetical protein 4058116 yiiF 8177911 yiiF Escherichia coli B str. REL606 hypothetical protein YP_003046948.1 4057898 D 413997 CDS YP_003046949.1 254163841 8178793 complement(4058446..4059375) 1 NC_012967.1 required for the formation of active formate dehydrogenase; formate dehydrogenase accessory protein FdhE 4059375 fdhE 8178793 fdhE Escherichia coli B str. REL606 formate dehydrogenase accessory protein FdhE YP_003046949.1 4058446 R 413997 CDS YP_003046950.1 254163842 8177912 complement(4059372..4060007) 1 NC_012967.1 cytochrome b556(FDO) component; heme containing; formate dehydrogenase-O subunit gamma 4060007 fdoI 8177912 fdoI Escherichia coli B str. REL606 formate dehydrogenase-O subunit gamma YP_003046950.1 4059372 R 413997 CDS YP_003046951.1 254163843 8179321 complement(4060004..4060906) 1 NC_012967.1 similar to b3893; formate dehydrogenase-O, Fe-S subunit 4060906 fdoH 8179321 fdoH Escherichia coli B str. REL606 formate dehydrogenase-O, Fe-S subunit YP_003046951.1 4060004 R 413997 CDS YP_003046952.1 254163844 8177913 complement(4060919..4063969) 1 NC_012967.1 similar to b3894; selenocysteine; formate dehydrogenase-O, major subunit 4063969 fdoG 8177913 fdoG Escherichia coli B str. REL606 formate dehydrogenase-O, major subunit YP_003046952.1 4060919 R 413997 CDS YP_003046953.1 254163845 8177914 4064163..4064996 1 NC_012967.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth; formate dehydrogenase accessory protein 4064996 fdhD 8177914 fdhD Escherichia coli B str. REL606 formate dehydrogenase accessory protein YP_003046953.1 4064163 D 413997 CDS YP_003046954.1 254163846 8177915 4065149..4066204 1 NC_012967.1 similar to b3896; hypothetical protein 4066204 yiiG 8177915 yiiG Escherichia coli B str. REL606 hypothetical protein YP_003046954.1 4065149 D 413997 CDS YP_003046955.1 254163847 8177916 complement(4066254..4068002) 1 NC_012967.1 putative repressor of the frv operon, involved in phosphoenolpyruvate:sugar phosphotransferase system; putative frv operon regulatory protein 4068002 frvR 8177916 frvR Escherichia coli B str. REL606 putative frv operon regulatory protein YP_003046955.1 4066254 R 413997 CDS YP_003046956.1 254163848 8179322 complement(4068002..4069072) 1 NC_012967.1 with FrvABR is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system which may be involved in the transport and phosphorylation of sugars; putative fructose-specific phosphotransferase system protein FrvX 4069072 frvX 8179322 frvX Escherichia coli B str. REL606 putative fructose-specific phosphotransferase system protein FrvX YP_003046956.1 4068002 R 413997 CDS YP_003046957.1 254163849 8177917 complement(4069062..4070513) 1 NC_012967.1 similar to b3899; putative PTS system transporter subunits IIBC 4070513 frvB 8177917 frvB Escherichia coli B str. REL606 putative PTS system transporter subunits IIBC YP_003046957.1 4069062 R 413997 CDS YP_003046958.1 254163850 8177918 complement(4070524..4070970) 1 NC_012967.1 with FrvBRX is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system involved in the transport and phosphorylation of sugars; possibly responsible for the sugar specificity of the system; putative fructose-like phosphotransferase system subunit EIIA 4070970 frvA 8177918 frvA Escherichia coli B str. REL606 putative fructose-like phosphotransferase system subunit EIIA YP_003046958.1 4070524 R 413997 CDS YP_003046959.1 254163851 8177919 4071447..4072841 1 NC_012967.1 putative glycoporin 4072841 8177919 ECB_03786 Escherichia coli B str. REL606 putative glycoporin YP_003046959.1 4071447 D 413997 CDS YP_003046960.1 254163852 8177920 complement(4072882..4073196) 1 NC_012967.1 similar to b3901; L-rhamnose mutarotase 4073196 yiiL 8177920 yiiL Escherichia coli B str. REL606 L-rhamnose mutarotase YP_003046960.1 4072882 R 413997 CDS YP_003046961.1 254163853 8179323 complement(4073206..4074030) 1 NC_012967.1 similar to b3902; rhamnulose-1-phosphate aldolase 4074030 rhaD 8179323 rhaD Escherichia coli B str. REL606 rhamnulose-1-phosphate aldolase YP_003046961.1 4073206 R 413997 CDS YP_003046962.1 254163854 8177921 complement(4074205..4075470) 1 NC_012967.1 catalyzes the formation of L-rhamnulose from L-rhamnose; L-rhamnose isomerase 4075470 rhaA 8177921 rhaA Escherichia coli B str. REL606 L-rhamnose isomerase YP_003046962.1 4074205 R 413997 CDS YP_003046963.1 254163855 8177922 complement(4075461..4076930) 1 NC_012967.1 catalyzes the ATP-dependent phosphorylation of rhamnulose; rhamnulokinase 4076930 rhaB 8177922 rhaB Escherichia coli B str. REL606 rhamnulokinase YP_003046963.1 4075461 R 413997 CDS YP_003046964.1 254163856 8177923 4077218..4078054 1 NC_012967.1 activates the expression of the rhaBAD operon and rhaT gene; transcriptional activator RhaS 4078054 rhaS 8177923 rhaS Escherichia coli B str. REL606 transcriptional activator RhaS YP_003046964.1 4077218 D 413997 CDS YP_003046965.1 254163857 8177924 4078038..4078976 1 NC_012967.1 activates the expression of rhaRS in response to L-rhamnose; transcriptional activator RhaR 4078976 rhaR 8177924 rhaR Escherichia coli B str. REL606 transcriptional activator RhaR YP_003046965.1 4078038 D 413997 CDS YP_003046966.1 254163858 8178794 complement(4078973..4080007) 1 NC_012967.1 transports L-rhamnose and L-lyxose into the cell; rhamnose-proton symporter 4080007 rhaT 8178794 rhaT Escherichia coli B str. REL606 rhamnose-proton symporter YP_003046966.1 4078973 R 413997 CDS YP_003046967.1 254163859 8177925 4080292..4080912 1 NC_012967.1 SodA; manganese binding; only present under aerobic conditions; destroys free radicals; superoxide dismutase 4080912 sodA 8177925 sodA Escherichia coli B str. REL606 superoxide dismutase YP_003046967.1 4080292 D 413997 CDS YP_003046968.1 254163860 8177926 4081172..4082155 1 NC_012967.1 transports degraded pectin products into the bacterial cell; 2-keto-3-deoxygluconate permease 4082155 kdgT 8177926 kdgT Escherichia coli B str. REL606 2-keto-3-deoxygluconate permease YP_003046968.1 4081172 D 413997 CDS YP_003046969.1 254163861 8178795 4082304..4082978 1 NC_012967.1 similar to b3910; hypothetical protein 4082978 yiiM 8178795 yiiM Escherichia coli B str. REL606 hypothetical protein YP_003046969.1 4082304 D 413997 CDS YP_003046970.1 254163862 8177927 complement(4083084..4084457) 1 NC_012967.1 part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors; two-component sensor protein 4084457 cpxA 8177927 cpxA Escherichia coli B str. REL606 two-component sensor protein YP_003046970.1 4083084 R 413997 CDS YP_003046971.1 254163863 8179324 complement(4084454..4085152) 1 NC_012967.1 response regulator in two-component regulatory system with CpxA; part of the envelope stress response system; DNA-binding transcriptional regulator CpxR 4085152 cpxR 8179324 cpxR Escherichia coli B str. REL606 DNA-binding transcriptional regulator CpxR YP_003046971.1 4084454 R 413997 CDS YP_003046972.1 254163864 8177928 4085302..4085802 1 NC_012967.1 repressor of the Cpx envelope stress response pathway which occurs via periplasmic interactions with CpxA; CpxP is degraded by DegP protease especially in the presence of misfolded substrates; periplasmic repressor CpxP 4085802 cpxP 8177928 cpxP Escherichia coli B str. REL606 periplasmic repressor CpxP YP_003046972.1 4085302 D 413997 CDS YP_003046973.1 254163865 8177929 4085951..4086853 1 NC_012967.1 member of cation diffusion facilitator family; CDF; membrane-bound; induced by both zinc and iron, but does not induce resistance to zinc; can transport zinc(II) in a proton-dependent manner; instead this protein induces iron resistance; forms dimers; ferrous iron efflux protein F 4086853 fieF 8177929 fieF Escherichia coli B str. REL606 ferrous iron efflux protein F YP_003046973.1 4085951 D 413997 CDS YP_003046974.1 254163866 8177930 4087034..4087996 1 NC_012967.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 4087996 pfkA 8177930 pfkA Escherichia coli B str. REL606 6-phosphofructokinase YP_003046974.1 4087034 D 413997 CDS YP_003046975.1 254163867 8177931 4088316..4089305 1 NC_012967.1 similar to b3917; sulfate transporter subunit 4089305 sbp 8177931 sbp Escherichia coli B str. REL606 sulfate transporter subunit YP_003046975.1 4088316 D 413997 CDS YP_003046976.1 254163868 8177932 4089412..4090167 1 NC_012967.1 similar to b3918; CDP-diacylglycerol pyrophosphatase 4090167 cdh 8177932 cdh Escherichia coli B str. REL606 CDP-diacylglycerol pyrophosphatase YP_003046976.1 4089412 D 413997 CDS YP_003046977.1 254163869 8179325 complement(4090222..4090989) 1 NC_012967.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 4090989 tpiA 8179325 tpiA Escherichia coli B str. REL606 triosephosphate isomerase YP_003046977.1 4090222 R 413997 CDS YP_003046978.1 254163870 8177933 complement(4091097..4091696) 1 NC_012967.1 similar to b3920; hypothetical protein 4091696 yiiQ 8177933 yiiQ Escherichia coli B str. REL606 hypothetical protein YP_003046978.1 4091097 R 413997 CDS YP_003046979.1 254163871 8177934 4091797..4092237 1 NC_012967.1 similar to b3921; inner membrane protein 4092237 yiiR 8177934 yiiR Escherichia coli B str. REL606 inner membrane protein YP_003046979.1 4091797 D 413997 CDS YP_003046980.1 254163872 8177935 4092449..4092748 1 NC_012967.1 similar to b3922; hypothetical protein 4092748 yiiS 8177935 yiiS Escherichia coli B str. REL606 hypothetical protein YP_003046980.1 4092449 D 413997 CDS YP_003046981.1 254163873 8177936 4092775..4093203 1 NC_012967.1 with UspC and Usp E is involved in resistance to UV radiation; universal stress protein UspD 4093203 yiiT 8177936 yiiT Escherichia coli B str. REL606 universal stress protein UspD YP_003046981.1 4092775 D 413997 CDS YP_003046982.1 254163874 8179326 complement(4093208..4093954) 1 NC_012967.1 similar to b3924; ferredoxin-NADP reductase 4093954 fpr 8179326 fpr Escherichia coli B str. REL606 ferredoxin-NADP reductase YP_003046982.1 4093208 R 413997 CDS YP_003046983.1 254163875 8177937 complement(4094051..4095061) 1 NC_012967.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II 4095061 glpX 8177937 glpX Escherichia coli B str. REL606 fructose 1,6-bisphosphatase II YP_003046983.1 4094051 R 413997 CDS YP_003046984.1 254163876 8177938 complement(4095196..4096704) 1 NC_012967.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase 4096704 glpK 8177938 glpK Escherichia coli B str. REL606 glycerol kinase YP_003046984.1 4095196 R 413997 CDS YP_003046985.1 254163877 8177939 complement(4096727..4097572) 1 NC_012967.1 similar to b3927; glycerol facilitator 4097572 glpF 8177939 glpF Escherichia coli B str. REL606 glycerol facilitator YP_003046985.1 4096727 R 413997 CDS YP_003046986.1 254163878 8179327 4097998..4098243 1 NC_012967.1 similar to b3928; hypothetical protein 4098243 yiiU 8179327 yiiU Escherichia coli B str. REL606 hypothetical protein YP_003046986.1 4097998 D 413997 CDS YP_003046987.1 254163879 8177940 complement(4098328..4098813) 1 NC_012967.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA 4098813 menG 8177940 menG Escherichia coli B str. REL606 ribonuclease activity regulator protein RraA YP_003046987.1 4098328 R 413997 CDS YP_003046988.1 254163880 8177941 complement(4098906..4099832) 1 NC_012967.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase 4099832 menA 8177941 menA Escherichia coli B str. REL606 1,4-dihydroxy-2-naphthoate octaprenyltransferase YP_003046988.1 4098906 R 413997 CDS YP_003046989.1 254163881 8177942 complement(4099899..4101230) 1 NC_012967.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU 4101230 hslU 8177942 hslU Escherichia coli B str. REL606 ATP-dependent protease ATP-binding subunit HslU YP_003046989.1 4099899 R 413997 CDS YP_003046990.1 254163882 8177943 complement(4101240..4101770) 1 NC_012967.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit 4101770 hslV 8177943 hslV Escherichia coli B str. REL606 ATP-dependent protease peptidase subunit YP_003046990.1 4101240 R 413997 CDS YP_003046991.1 254163883 8179328 complement(4101863..4102822) 1 NC_012967.1 similar to b3933; essential cell division protein FtsN 4102822 ftsN 8179328 ftsN Escherichia coli B str. REL606 essential cell division protein FtsN YP_003046991.1 4101863 R 413997 CDS YP_003046992.1 254163884 8178796 complement(4102914..4103939) 1 NC_012967.1 negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins; DNA-binding transcriptional regulator CytR 4103939 cytR 8178796 cytR Escherichia coli B str. REL606 DNA-binding transcriptional regulator CytR YP_003046992.1 4102914 R 413997 CDS YP_003046993.1 254163885 8177944 complement(4104095..4106293) 1 NC_012967.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 4106293 priA 8177944 priA Escherichia coli B str. REL606 primosome assembly protein PriA YP_003046993.1 4104095 R 413997 CDS YP_003046994.1 254163886 8177945 4106496..4106708 1 NC_012967.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 4106708 rpmE 8177945 rpmE Escherichia coli B str. REL606 50S ribosomal protein L31 YP_003046994.1 4106496 D 413997 CDS YP_003046995.1 254163887 8178797 complement(4106763..4107386) 1 NC_012967.1 putative outer membrane lipoprotein 4107386 8178797 ECB_03822 Escherichia coli B str. REL606 putative outer membrane lipoprotein YP_003046995.1 4106763 R 413997 CDS YP_003046996.1 254163888 8177946 complement(4107393..4108001) 1 NC_012967.1 member of the NlpC/P60 superfamily of peptidases; putative peptidoglycan peptidase 4108001 yiiX 8177946 yiiX Escherichia coli B str. REL606 putative peptidoglycan peptidase YP_003046996.1 4107393 R 413997 CDS YP_003046997.1 254163889 8179329 complement(4108185..4108502) 1 NC_012967.1 when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis; transcriptional repressor protein MetJ 4108502 metJ 8179329 metJ Escherichia coli B str. REL606 transcriptional repressor protein MetJ YP_003046997.1 4108185 R 413997 CDS YP_003046998.1 254163890 8177947 4108779..4109939 1 NC_012967.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase 4109939 metB 8177947 metB Escherichia coli B str. REL606 cystathionine gamma-synthase YP_003046998.1 4108779 D 413997 CDS YP_003046999.1 254163891 8177948 4109942..4112374 1 NC_012967.1 multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartate kinase II/homoserine dehydrogenase II 4112374 metL 8177948 metL Escherichia coli B str. REL606 bifunctional aspartate kinase II/homoserine dehydrogenase II YP_003046999.1 4109942 D 413997 CDS YP_003047000.1 254163892 8177949 4112723..4113613 1 NC_012967.1 MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor; 5,10-methylenetetrahydrofolate reductase 4113613 metF 8177949 metF Escherichia coli B str. REL606 5,10-methylenetetrahydrofolate reductase YP_003047000.1 4112723 D 413997 CDS YP_003047001.1 254163893 8179330 4113942..4116122 1 NC_012967.1 similar to b3942; catalase/hydroperoxidase HPI(I) 4116122 katG 8179330 katG Escherichia coli B str. REL606 catalase/hydroperoxidase HPI(I) YP_003047001.1 4113942 D 413997 CDS YP_003047002.1 254163894 8177950 4116215..4117120 1 NC_012967.1 similar to b3943; putative permease 4117120 yijE 8177950 yijE Escherichia coli B str. REL606 putative permease YP_003047002.1 4116215 D 413997 CDS YP_003047003.1 254163895 8177951 complement(4117147..4117764) 1 NC_012967.1 similar to b3944; hypothetical protein 4117764 yijF 8177951 yijF Escherichia coli B str. REL606 hypothetical protein YP_003047003.1 4117147 R 413997 CDS YP_003047004.1 254163896 8177952 complement(4118039..4119142) 1 NC_012967.1 forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; glycerol dehydrogenase 4119142 gldA 8177952 gldA Escherichia coli B str. REL606 glycerol dehydrogenase YP_003047004.1 4118039 R 413997 CDS YP_003047005.1 254163897 8177953 complement(4119153..4119815) 1 NC_012967.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 4119815 talC 8177953 talC Escherichia coli B str. REL606 fructose-6-phosphate aldolase YP_003047005.1 4119153 R 413997 CDS YP_003047006.1 254163898 8179331 complement(4119827..4122328) 1 NC_012967.1 similar to b3947; PTS system Hpr component subunit IIA 4122328 ptsA 8179331 ptsA Escherichia coli B str. REL606 PTS system Hpr component subunit IIA YP_003047006.1 4119827 R 413997 CDS YP_003047007.1 254163899 8177954 4122637..4123716 1 NC_012967.1 FrwC with FrwB, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; forms translocation channel and contains the specific substrate-binding site; putative fructose-like permease EIIC subunit 2 4123716 frwC 8177954 frwC Escherichia coli B str. REL606 putative fructose-like permease EIIC subunit 2 YP_003047007.1 4122637 D 413997 CDS YP_003047008.1 254163900 8177955 4123731..4124051 1 NC_012967.1 FrwB with FrwC, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system (PTS) permease which may phosphorylate and transport sugars into the cell; cytoplasmic protein that interacts with complex EIIA; contains the second phosphorylation site of the PTS; putative PTS system fructose-like transporter subunit EIIB 4124051 frwB 8177955 frwB Escherichia coli B str. REL606 putative PTS system fructose-like transporter subunit EIIB YP_003047008.1 4123731 D 413997 CDS YP_003047009.1 254163901 8177956 4124102..4126399 1 NC_012967.1 involved in production of D-lactate from glucose under microaerobic conditions; cytoplasmic protein; putative formate acetyltransferase 2 4126399 pflD 8177956 pflD Escherichia coli B str. REL606 putative formate acetyltransferase 2 YP_003047009.1 4124102 D 413997 CDS YP_003047010.1 254163902 8177957 4126365..4127243 1 NC_012967.1 similar to b3952; pyruvate formate lyase II activase 4127243 pflC 8177957 pflC Escherichia coli B str. REL606 pyruvate formate lyase II activase YP_003047010.1 4126365 D 413997 CDS YP_003047011.1 254163903 8177958 4127245..4127586 1 NC_012967.1 FrwD with FrwB, FrwC and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; phosphorylated by EIIA; FrwB homolog; putative fructose-like phosphotransferase EIIB subunit 3 4127586 frwD 8177958 frwD Escherichia coli B str. REL606 putative fructose-like phosphotransferase EIIB subunit 3 YP_003047011.1 4127245 D 413997 CDS YP_003047012.1 254163904 8178798 complement(4127573..4128424) 1 NC_012967.1 similar to b3954; putative DNA-binding transcriptional regulator 4128424 yijO 8178798 yijO Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003047012.1 4127573 R 413997 CDS YP_003047013.1 254163905 8177959 complement(4128639..4130372) 1 NC_012967.1 similar to b3955; hypothetical protein 4130372 yijP 8177959 yijP Escherichia coli B str. REL606 hypothetical protein YP_003047013.1 4128639 R 413997 CDS YP_003047014.1 254163906 8177960 complement(4130554..4133205) 1 NC_012967.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 4133205 ppc 8177960 ppc Escherichia coli B str. REL606 phosphoenolpyruvate carboxylase YP_003047014.1 4130554 R 413997 CDS YP_003047015.1 254163907 8178799 complement(4133557..4134708) 1 NC_012967.1 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis; acetylornithine deacetylase 4134708 argE 8178799 argE Escherichia coli B str. REL606 acetylornithine deacetylase YP_003047015.1 4133557 R 413997 CDS YP_003047016.1 254163908 8177961 4134862..4135866 1 NC_012967.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase 4135866 argC 8177961 argC Escherichia coli B str. REL606 N-acetyl-gamma-glutamyl-phosphate reductase YP_003047016.1 4134862 D 413997 CDS YP_003047017.1 254163909 8178800 4135877..4136650 1 NC_012967.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 4136650 argB 8178800 argB Escherichia coli B str. REL606 acetylglutamate kinase YP_003047017.1 4135877 D 413997 CDS YP_003047018.1 254163910 8177962 4136711..4138084 1 NC_012967.1 catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 4138084 argH 8177962 argH Escherichia coli B str. REL606 argininosuccinate lyase YP_003047018.1 4136711 D 413997 CDS YP_003047019.1 254163911 8177963 4138351..4139268 1 NC_012967.1 Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA; DNA-binding transcriptional regulator OxyR 4139268 oxyR 8177963 oxyR Escherichia coli B str. REL606 DNA-binding transcriptional regulator OxyR YP_003047019.1 4138351 D 413997 CDS YP_003047020.1 254163912 8177964 complement(4139251..4140651) 1 NC_012967.1 catalyzes the conversion of NADPH to NADH; soluble pyridine nucleotide transhydrogenase 4140651 udhA 8177964 udhA Escherichia coli B str. REL606 soluble pyridine nucleotide transhydrogenase YP_003047020.1 4139251 R 413997 CDS YP_003047021.1 254163913 8177965 4140928..4141632 1 NC_012967.1 negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis; DNA-binding transcriptional repressor FabR 4141632 yijC 8177965 yijC Escherichia coli B str. REL606 DNA-binding transcriptional repressor FabR YP_003047021.1 4140928 D 413997 CDS YP_003047022.1 254163914 8178801 4141632..4141991 1 NC_012967.1 similar to b3964; hypothetical protein 4141991 yijD 8178801 yijD Escherichia coli B str. REL606 hypothetical protein YP_003047022.1 4141632 D 413997 CDS YP_003047023.1 254163915 8177966 complement(4142031..4143131) 1 NC_012967.1 catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs; tRNA (uracil-5-)-methyltransferase 4143131 trmA 8177966 trmA Escherichia coli B str. REL606 tRNA (uracil-5-)-methyltransferase YP_003047023.1 4142031 R 413997 CDS YP_003047024.1 254163916 8177967 4143500..4145344 1 NC_012967.1 involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space; vitamin B12/cobalamin outer membrane transporter 4145344 btuB 8177967 btuB Escherichia coli B str. REL606 vitamin B12/cobalamin outer membrane transporter YP_003047024.1 4143500 D 413997 CDS YP_003047025.1 254163917 8179332 4145289..4146146 1 NC_012967.1 converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 4146146 murI 8179332 murI Escherichia coli B str. REL606 glutamate racemase YP_003047025.1 4145289 D 413997 CDS YP_003047026.1 254163918 8177972 4151668..4152696 1 NC_012967.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 4152696 murB 8177972 murB Escherichia coli B str. REL606 UDP-N-acetylenolpyruvoylglucosamine reductase YP_003047026.1 4151668 D 413997 CDS YP_003047027.1 254163919 8177973 4152693..4153658 1 NC_012967.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 4153658 birA 8177973 birA Escherichia coli B str. REL606 biotin--protein ligase YP_003047027.1 4152693 D 413997 CDS YP_003047028.1 254163920 8177974 complement(4153687..4154637) 1 NC_012967.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 4154637 coaA 8177974 coaA Escherichia coli B str. REL606 pantothenate kinase YP_003047028.1 4153687 R 413997 CDS YP_003047029.1 254163921 8177978 4155555..4156739 1 NC_012967.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 4156739 tufB 8177978 tufB Escherichia coli B str. REL606 elongation factor Tu YP_003047029.1 4155555 D 413997 CDS YP_003047030.1 254163922 8177979 4156969..4157352 1 NC_012967.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 4157352 secE 8177979 secE Escherichia coli B str. REL606 preprotein translocase subunit SecE YP_003047030.1 4156969 D 413997 CDS YP_003047031.1 254163923 8177980 4157354..4157899 1 NC_012967.1 Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 4157899 nusG 8177980 nusG Escherichia coli B str. REL606 transcription antitermination protein NusG YP_003047031.1 4157354 D 413997 CDS YP_003047032.1 254163924 8179334 4158058..4158486 1 NC_012967.1 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 4158486 rplK 8179334 rplK Escherichia coli B str. REL606 50S ribosomal protein L11 YP_003047032.1 4158058 D 413997 CDS YP_003047033.1 254163925 8177981 4158490..4159194 1 NC_012967.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 4159194 rplA 8177981 rplA Escherichia coli B str. REL606 50S ribosomal protein L1 YP_003047033.1 4158490 D 413997 CDS YP_003047034.1 254163926 8177982 4159607..4160104 1 NC_012967.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 4160104 rplJ 8177982 rplJ Escherichia coli B str. REL606 50S ribosomal protein L10 YP_003047034.1 4159607 D 413997 CDS YP_003047035.1 254163927 8178802 4160171..4160536 1 NC_012967.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 4160536 rplL 8178802 rplL Escherichia coli B str. REL606 50S ribosomal protein L7/L12 YP_003047035.1 4160171 D 413997 CDS YP_003047036.1 254163928 8177983 4160856..4164884 1 NC_012967.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 4164884 rpoB 8177983 rpoB Escherichia coli B str. REL606 DNA-directed RNA polymerase subunit beta YP_003047036.1 4160856 D 413997 CDS YP_003047037.1 254163929 8179335 4164961..4169184 1 NC_012967.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 4169184 rpoC 8179335 rpoC Escherichia coli B str. REL606 DNA-directed RNA polymerase subunit beta' YP_003047037.1 4164961 D 413997 CDS YP_003047038.1 254163930 8177984 4169397..4169936 1 NC_012967.1 similar to b3989; heat shock protein 4169936 htrC 8177984 htrC Escherichia coli B str. REL606 heat shock protein YP_003047038.1 4169397 D 413997 CDS YP_003047039.1 254163931 8177985 complement(4170346..4171479) 1 NC_012967.1 in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center; thiamine biosynthesis protein ThiH 4171479 thiH 8177985 thiH Escherichia coli B str. REL606 thiamine biosynthesis protein ThiH YP_003047039.1 4170346 R 413997 CDS YP_003047040.1 254163932 8177986 complement(4171476..4172246) 1 NC_012967.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase 4172246 thiG 8177986 thiG Escherichia coli B str. REL606 thiazole synthase YP_003047040.1 4171476 R 413997 CDS YP_003047041.1 254163933 8179336 complement(4172248..4172448) 1 NC_012967.1 with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate; sulfur carrier protein ThiS 4172448 thiS 8179336 thiS Escherichia coli B str. REL606 sulfur carrier protein ThiS YP_003047041.1 4172248 R 413997 CDS YP_003047042.1 254163934 8177987 complement(4172432..4173187) 1 NC_012967.1 similar to b3992; thiamine biosynthesis protein ThiF 4173187 thiF 8177987 thiF Escherichia coli B str. REL606 thiamine biosynthesis protein ThiF YP_003047042.1 4172432 R 413997 CDS YP_003047043.1 254163935 8177988 complement(4173180..4173815) 1 NC_012967.1 catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate; thiamine-phosphate pyrophosphorylase 4173815 thiE 8177988 thiE Escherichia coli B str. REL606 thiamine-phosphate pyrophosphorylase YP_003047043.1 4173180 R 413997 CDS YP_003047044.1 254163936 8177989 complement(4173815..4175710) 1 NC_012967.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC 4175710 thiC 8177989 thiC Escherichia coli B str. REL606 thiamine biosynthesis protein ThiC YP_003047044.1 4173815 R 413997 CDS YP_003047045.1 254163937 8177990 complement(4175944..4176420) 1 NC_012967.1 binds specifically to the major sigma factor sigma 70; active in stationary phase; anti-RNA polymerase sigma 70 factor 4176420 rsd 8177990 rsd Escherichia coli B str. REL606 anti-RNA polymerase sigma 70 factor YP_003047045.1 4175944 R 413997 CDS YP_003047046.1 254163938 8177991 4176515..4177288 1 NC_012967.1 can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates; NADH pyrophosphatase 4177288 nudC 8177991 nudC Escherichia coli B str. REL606 NADH pyrophosphatase YP_003047046.1 4176515 D 413997 CDS YP_003047047.1 254163939 8178803 4177328..4178392 1 NC_012967.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 4178392 hemE 8178803 hemE Escherichia coli B str. REL606 uroporphyrinogen decarboxylase YP_003047047.1 4177328 D 413997 CDS YP_003047048.1 254163940 8177992 4178402..4179073 1 NC_012967.1 Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA; cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures; endonuclease V 4179073 nfi 8177992 nfi Escherichia coli B str. REL606 endonuclease V YP_003047048.1 4178402 D 413997 CDS YP_003047049.1 254163941 8177993 4179116..4179706 1 NC_012967.1 similar to b3999; hypothetical protein 4179706 yjaG 8177993 yjaG Escherichia coli B str. REL606 hypothetical protein YP_003047049.1 4179116 D 413997 CDS YP_003047050.1 254163942 8179337 4179893..4180165 1 NC_012967.1 histone-like DNA-binding protein; transcriptional regulator HU subunit alpha 4180165 hupA 8179337 hupA Escherichia coli B str. REL606 transcriptional regulator HU subunit alpha YP_003047050.1 4179893 D 413997 CDS YP_003047051.1 254163943 8177994 4180178..4180873 1 NC_012967.1 similar to b4001; hypothetical protein 4180873 yjaH 8177994 yjaH Escherichia coli B str. REL606 hypothetical protein YP_003047051.1 4180178 D 413997 CDS YP_003047052.1 254163944 8177995 complement(4180875..4181294) 1 NC_012967.1 similar to b4002; zinc resistance protein 4181294 zraP 8177995 zraP Escherichia coli B str. REL606 zinc resistance protein YP_003047052.1 4180875 R 413997 CDS YP_003047053.1 254163945 8177996 4181532..4182908 1 NC_012967.1 similar to b4003; sensor protein ZraS 4182908 zraS 8177996 zraS Escherichia coli B str. REL606 sensor protein ZraS YP_003047053.1 4181532 D 413997 CDS YP_003047054.1 254163946 8177997 4182905..4184230 1 NC_012967.1 DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein; transcriptional regulatory protein ZraR 4184230 zraR 8177997 zraR Escherichia coli B str. REL606 transcriptional regulatory protein ZraR YP_003047054.1 4182905 D 413997 CDS YP_003047055.1 254163947 8179338 complement(4184227..4185516) 1 NC_012967.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 4185516 purD 8179338 purD Escherichia coli B str. REL606 phosphoribosylamine--glycine ligase YP_003047055.1 4184227 R 413997 CDS YP_003047056.1 254163948 8177998 complement(4185528..4187117) 1 NC_012967.1 involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 4187117 purH 8177998 purH Escherichia coli B str. REL606 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase YP_003047056.1 4185528 R 413997 CDS YP_003047057.1 254163949 8178001 complement(4193125..4193568) 1 NC_012967.1 similar to b4012; hypothetical protein 4193568 yjaB 8178001 yjaB Escherichia coli B str. REL606 hypothetical protein YP_003047057.1 4193125 R 413997 CDS YP_003047058.1 254163950 8178002 4193725..4194654 1 NC_012967.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase 4194654 metA 8178002 metA Escherichia coli B str. REL606 homoserine O-succinyltransferase YP_003047058.1 4193725 D 413997 CDS YP_003047059.1 254163951 8178003 4194923..4196524 1 NC_012967.1 Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle; malate synthase 4196524 aceB 8178003 aceB Escherichia coli B str. REL606 malate synthase YP_003047059.1 4194923 D 413997 CDS YP_003047060.1 254163952 8178004 4196554..4197858 1 NC_012967.1 similar to b4015; isocitrate lyase 4197858 aceA 8178004 aceA Escherichia coli B str. REL606 isocitrate lyase YP_003047060.1 4196554 D 413997 CDS YP_003047061.1 254163953 8178005 4198139..4199875 1 NC_012967.1 catalyzes the phosphorylation/dephosphorylation of the enzyme isocitrate dehydrogenase on a specific serine which regulates activity; unphosphorylated IDH is fully active when cells are grown on glucose while the enzyme becomes phosphorylated and inactive in the presence of acetate or ethanol; bifunctional isocitrate dehydrogenase kinase/phosphatase protein 4199875 aceK 8178005 aceK Escherichia coli B str. REL606 bifunctional isocitrate dehydrogenase kinase/phosphatase protein YP_003047061.1 4198139 D 413997 CDS YP_003047062.1 254163954 8178806 complement(4201735..4202559) 1 NC_012967.1 regulates the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase and isocitrate dehydrogenase kinase/phosphorylase; transcriptional repressor IclR 4202559 iclR 8178806 iclR Escherichia coli B str. REL606 transcriptional repressor IclR YP_003047062.1 4201735 R 413997 CDS YP_003047063.1 254163955 8178007 4202759..4206442 1 NC_012967.1 one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity; B12-dependent methionine synthase 4206442 metH 8178007 metH Escherichia coli B str. REL606 B12-dependent methionine synthase YP_003047063.1 4202759 D 413997 CDS YP_003047064.1 254163956 8178807 4206662..4208293 1 NC_012967.1 similar to b4020; putative transporter 4208293 yjbB 8178807 yjbB Escherichia coli B str. REL606 putative transporter YP_003047064.1 4206662 D 413997 CDS YP_003047065.1 254163957 8178008 complement(4208384..4209073) 1 NC_012967.1 alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family; peptidase E 4209073 pepE 8178008 pepE Escherichia coli B str. REL606 peptidase E YP_003047065.1 4208384 R 413997 CDS YP_003047066.1 254163958 8178009 4209285..4210157 1 NC_012967.1 catalyzes the synthesis of pseudouridine from U-2604 in the 23S ribosomal RNA; 23S rRNA pseudouridine synthase F 4210157 yjbC 8178009 yjbC Escherichia coli B str. REL606 23S rRNA pseudouridine synthase F YP_003047066.1 4209285 D 413997 CDS YP_003047067.1 254163959 8178808 complement(4210290..4210562) 1 NC_012967.1 similar to b4023; hypothetical protein 4210562 yjbD 8178808 yjbD Escherichia coli B str. REL606 hypothetical protein YP_003047067.1 4210290 R 413997 CDS YP_003047068.1 254163960 8178010 complement(4210815..4212164) 1 NC_012967.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive; aspartate kinase III 4212164 lysC 8178010 lysC Escherichia coli B str. REL606 aspartate kinase III YP_003047068.1 4210815 R 413997 CDS YP_003047069.1 254163961 8178011 4212689..4214338 1 NC_012967.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 4214338 pgi 8178011 pgi Escherichia coli B str. REL606 glucose-6-phosphate isomerase YP_003047069.1 4212689 D 413997 CDS YP_003047070.1 254163962 8178012 4214837..4215079 1 NC_012967.1 similar to b4026; hypothetical protein 4215079 yjbE 8178012 yjbE Escherichia coli B str. REL606 hypothetical protein YP_003047070.1 4214837 D 413997 CDS YP_003047071.1 254163963 8178013 4215194..4215832 1 NC_012967.1 similar to b4027; putative lipoprotein 4215832 yjbF 8178013 yjbF Escherichia coli B str. REL606 putative lipoprotein YP_003047071.1 4215194 D 413997 CDS YP_003047072.1 254163964 8179339 4215829..4216566 1 NC_012967.1 similar to b4028; hypothetical protein 4216566 yjbG 8179339 yjbG Escherichia coli B str. REL606 hypothetical protein YP_003047072.1 4215829 D 413997 CDS YP_003047073.1 254163965 8178014 4216566..4218662 1 NC_012967.1 similar to b4029; putative porin 4218662 yjbH 8178014 yjbH Escherichia coli B str. REL606 putative porin YP_003047073.1 4216566 D 413997 CDS YP_003047074.1 254163966 8178015 4219257..4219667 1 NC_012967.1 similar to b4030; phosphate-starvation-inducible protein PsiE 4219667 yjbA 8178015 yjbA Escherichia coli B str. REL606 phosphate-starvation-inducible protein PsiE YP_003047074.1 4219257 D 413997 CDS YP_003047075.1 254163967 8178016 complement(4219711..4221186) 1 NC_012967.1 xylose/proton symporter; member of the major facilitator superfamily (MFS) of transporter; D-xylose transporter XylE 4221186 xylE 8178016 xylE Escherichia coli B str. REL606 D-xylose transporter XylE YP_003047075.1 4219711 R 413997 CDS YP_003047076.1 254163968 8178809 complement(4221558..4222448) 1 NC_012967.1 with MalKFE is involved in the transport of maltose into the cell; maltose transporter permease 4222448 malG 8178809 malG Escherichia coli B str. REL606 maltose transporter permease YP_003047076.1 4221558 R 413997 CDS YP_003047077.1 254163969 8178017 complement(4222463..4224007) 1 NC_012967.1 with MalKGE is involved in maltose transport into the cell; maltose transporter membrane protein 4224007 malF 8178017 malF Escherichia coli B str. REL606 maltose transporter membrane protein YP_003047077.1 4222463 R 413997 CDS YP_003047078.1 254163970 8178018 complement(4224161..4225351) 1 NC_012967.1 functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis; maltose ABC transporter periplasmic protein 4225351 malE 8178018 malE Escherichia coli B str. REL606 maltose ABC transporter periplasmic protein YP_003047078.1 4224161 R 413997 CDS YP_003047079.1 254163971 8179340 4225716..4226831 1 NC_012967.1 with malEFG is involved in import of maltose/maltodextrin; maltose/maltodextrin transporter ATP-binding protein 4226831 malK 8179340 malK Escherichia coli B str. REL606 maltose/maltodextrin transporter ATP-binding protein YP_003047079.1 4225716 D 413997 CDS YP_003047080.1 254163972 8178019 4226903..4228243 1 NC_012967.1 porin involved in the transport of maltose and maltodextrins; maltoporin 4228243 lamB 8178019 lamB Escherichia coli B str. REL606 maltoporin YP_003047080.1 4226903 D 413997 CDS YP_003047081.1 254163973 8178810 4228486..4229406 1 NC_012967.1 similar to b4037; maltose regulon periplasmic protein 4229406 malM 8178810 malM Escherichia coli B str. REL606 maltose regulon periplasmic protein YP_003047081.1 4228486 D 413997 CDS YP_003047082.1 254163974 8178020 4229887..4231215 1 NC_012967.1 in E. coli, some yjbl mutations have been reported as suppressors of dnaG mutations; hypothetical protein 4231215 yjbI 8178020 yjbI Escherichia coli B str. REL606 hypothetical protein YP_003047082.1 4229887 D 413997 CDS YP_003047083.1 254163975 8178021 4231438..4231935 1 NC_012967.1 catalyzes the formation of 4-hydroxybenzoate from chorismate; chorismate pyruvate lyase 4231935 ubiC 8178021 ubiC Escherichia coli B str. REL606 chorismate pyruvate lyase YP_003047083.1 4231438 D 413997 CDS YP_003047084.1 254163976 8178022 4231948..4232820 1 NC_012967.1 catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway; 4-hydroxybenzoate octaprenyltransferase 4232820 ubiA 8178022 ubiA Escherichia coli B str. REL606 4-hydroxybenzoate octaprenyltransferase YP_003047084.1 4231948 D 413997 CDS YP_003047085.1 254163977 8178023 complement(4232975..4235398) 1 NC_012967.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase 4235398 plsB 8178023 plsB Escherichia coli B str. REL606 glycerol-3-phosphate acyltransferase YP_003047085.1 4232975 R 413997 CDS YP_003047086.1 254163978 8178024 4235569..4235937 1 NC_012967.1 similar to b4042; diacylglycerol kinase 4235937 dgkA 8178024 dgkA Escherichia coli B str. REL606 diacylglycerol kinase YP_003047086.1 4235569 D 413997 CDS YP_003047087.1 254163979 8178025 4236047..4236655 1 NC_012967.1 Represses a number of genes involved in the response to DNA damage; LexA repressor 4236655 lexA 8178025 lexA Escherichia coli B str. REL606 LexA repressor YP_003047087.1 4236047 D 413997 CDS YP_003047088.1 254163980 8178026 4236674..4238053 1 NC_012967.1 similar to b4044; DNA-damage-inducible SOS response protein 4238053 dinF 8178026 dinF Escherichia coli B str. REL606 DNA-damage-inducible SOS response protein YP_003047088.1 4236674 D 413997 CDS YP_003047089.1 254163981 8179341 4238169..4238378 1 NC_012967.1 unknown function; highly abundant protein in vivo; overexpressed under high NaCl concentrations; part of the sigma S regulon; non-essential; putative stress-response protein 4238378 yjbJ 8179341 yjbJ Escherichia coli B str. REL606 putative stress-response protein YP_003047089.1 4238169 D 413997 CDS YP_003047090.1 254163982 8178027 complement(4238420..4238935) 1 NC_012967.1 Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes znuACB; zinc uptake transcriptional repressor 4238935 zur 8178027 zur Escherichia coli B str. REL606 zinc uptake transcriptional repressor YP_003047090.1 4238420 R 413997 CDS YP_003047091.1 254163983 8178028 4239253..4239507 1 NC_012967.1 similar to b4047; hypothetical protein 4239507 yjbL 8178028 yjbL Escherichia coli B str. REL606 hypothetical protein YP_003047091.1 4239253 D 413997 CDS YP_003047092.1 254163984 8178029 4239531..4240238 1 NC_012967.1 similar to b4048; hypothetical protein 4240238 yjbM 8178029 yjbM Escherichia coli B str. REL606 hypothetical protein YP_003047092.1 4239531 D 413997 CDS YP_003047093.1 254163985 8178811 4240601..4241638 1 NC_012967.1 similar to b4049; tRNA-dihydrouridine synthase A 4241638 yjbN 8178811 yjbN Escherichia coli B str. REL606 tRNA-dihydrouridine synthase A YP_003047093.1 4240601 D 413997 CDS YP_003047094.1 254163986 8178030 4241772..4242014 1 NC_012967.1 coordinately regulated along with pspA; PspF-dependent induction in response to secretin overexpression in Yersinia; phage shock protein G 4242014 pspG 8178030 pspG Escherichia coli B str. REL606 phage shock protein G YP_003047094.1 4241772 D 413997 CDS YP_003047095.1 254163987 8178031 complement(4242180..4243163) 1 NC_012967.1 similar to b4051; quinone oxidoreductase, NADPH-dependent 4243163 qor 8178031 qor Escherichia coli B str. REL606 quinone oxidoreductase, NADPH-dependent YP_003047095.1 4242180 R 413997 CDS YP_003047096.1 254163988 8178032 4243246..4244661 1 NC_012967.1 unwinds double stranded DNA; replicative DNA helicase 4244661 dnaB 8178032 dnaB Escherichia coli B str. REL606 replicative DNA helicase YP_003047096.1 4243246 D 413997 CDS YP_003047097.1 254163989 8178033 4244714..4245793 1 NC_012967.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 4245793 alr 8178033 alr Escherichia coli B str. REL606 alanine racemase YP_003047097.1 4244714 D 413997 CDS YP_003047098.1 254163990 8178034 4246046..4247239 1 NC_012967.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 4247239 tyrB 8178034 tyrB Escherichia coli B str. REL606 aromatic amino acid aminotransferase YP_003047098.1 4246046 D 413997 CDS YP_003047099.1 254163991 8178035 4248346..4249059 1 NC_012967.1 Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity; acid phosphatase/phosphotransferase 4249059 aphA 8178035 aphA Escherichia coli B str. REL606 acid phosphatase/phosphotransferase YP_003047099.1 4248346 D 413997 CDS YP_003047100.1 254163992 8178036 4249170..4249586 1 NC_012967.1 similar to b4056; hypothetical protein 4249586 yjbQ 8178036 yjbQ Escherichia coli B str. REL606 hypothetical protein YP_003047100.1 4249170 D 413997 CDS YP_003047101.1 254163993 8179342 4249590..4249946 1 NC_012967.1 similar to b4057; hypothetical protein 4249946 yjbR 8179342 yjbR Escherichia coli B str. REL606 hypothetical protein YP_003047101.1 4249590 D 413997 CDS YP_003047102.1 254163994 8178037 complement(4249981..4252803) 1 NC_012967.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 4252803 uvrA 8178037 uvrA Escherichia coli B str. REL606 excinuclease ABC subunit A YP_003047102.1 4249981 R 413997 CDS YP_003047103.1 254163995 8178038 4253058..4253594 1 NC_012967.1 binds to single stranded DNA and PriA helcase facilitate replication restart; single-stranded DNA-binding protein 4253594 ssb 8178038 ssb Escherichia coli B str. REL606 single-stranded DNA-binding protein YP_003047103.1 4253058 D 413997 CDS YP_003047104.1 254163996 8178039 complement(4253693..4253974) 1 NC_012967.1 similar to b4060; putative inner membrane protein 4253974 yjcB 8178039 yjcB Escherichia coli B str. REL606 putative inner membrane protein YP_003047104.1 4253693 R 413997 CDS YP_003047105.1 254163997 8179343 complement(4255993..4256316) 1 NC_012967.1 regulates genes involved in response to oxidative stress; DNA-binding transcriptional regulator SoxS 4256316 soxS 8179343 soxS Escherichia coli B str. REL606 DNA-binding transcriptional regulator SoxS YP_003047105.1 4255993 R 413997 CDS YP_003047106.1 254163998 8178041 4256402..4256866 1 NC_012967.1 similar to b4063; DNA-binding transcriptional dual regulator, Fe-S center for redox-sensing 4256866 soxR 8178041 soxR Escherichia coli B str. REL606 DNA-binding transcriptional dual regulator, Fe-S center for redox-sensing YP_003047106.1 4256402 D 413997 CDS YP_003047107.1 254163999 8178042 4257412..4258761 1 NC_012967.1 similar to b4064; putative permease 4258761 yjcD 8178042 yjcD Escherichia coli B str. REL606 putative permease YP_003047107.1 4257412 D 413997 CDS YP_003047108.1 254164000 8178043 4258913..4260562 1 NC_012967.1 similar to b4065; putative cation/proton antiporter 4260562 yjcE 8178043 yjcE Escherichia coli B str. REL606 putative cation/proton antiporter YP_003047108.1 4258913 D 413997 CDS YP_003047109.1 254164001 8178044 complement(4260716..4262008) 1 NC_012967.1 similar to b4066; hypothetical protein 4262008 yjcF 8178044 yjcF Escherichia coli B str. REL606 hypothetical protein YP_003047109.1 4260716 R 413997 CDS YP_003047110.1 254164002 8178045 complement(4262186..4263835) 1 NC_012967.1 member of the sodium:solute symporter family; cotranscribed with the acs gene which encodes acetyl coenzyme A synthase; mutations affect acetate uptake; acetate permease 4263835 actP 8178045 actP Escherichia coli B str. REL606 acetate permease YP_003047110.1 4262186 R 413997 CDS YP_003047111.1 254164003 8178046 complement(4263832..4264146) 1 NC_012967.1 similar to b4068; acetate transport inner membrane protein 4264146 yjcH 8178046 yjcH Escherichia coli B str. REL606 acetate transport inner membrane protein YP_003047111.1 4263832 R 413997 CDS YP_003047112.1 254164004 8178047 complement(4264346..4266304) 1 NC_012967.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA; acetyl-CoA synthetase 4266304 acs 8178047 acs Escherichia coli B str. REL606 acetyl-CoA synthetase YP_003047112.1 4264346 R 413997 CDS YP_003047113.1 254164005 8179344 4266697..4268133 1 NC_012967.1 catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552; cytochrome c552 4268133 nrfA 8179344 nrfA Escherichia coli B str. REL606 cytochrome c552 YP_003047113.1 4266697 D 413997 CDS YP_003047114.1 254164006 8178048 4268178..4268744 1 NC_012967.1 part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia; cytochrome c nitrite reductase pentaheme subunit 4268744 nrfB 8178048 nrfB Escherichia coli B str. REL606 cytochrome c nitrite reductase pentaheme subunit YP_003047114.1 4268178 D 413997 CDS YP_003047115.1 254164007 8178812 4268741..4269412 1 NC_012967.1 similar to b4072; formate-dependent nitrite reductase, 4Fe4S subunit 4269412 nrfC 8178812 nrfC Escherichia coli B str. REL606 formate-dependent nitrite reductase, 4Fe4S subunit YP_003047115.1 4268741 D 413997 CDS YP_003047116.1 254164008 8178049 4269409..4270365 1 NC_012967.1 similar to b4073; formate-dependent nitrite reductase, membrane subunit 4270365 nrfD 8178049 nrfD Escherichia coli B str. REL606 formate-dependent nitrite reductase, membrane subunit YP_003047116.1 4269409 D 413997 CDS YP_003047117.1 254164009 8178050 4270445..4272103 1 NC_012967.1 with NrfF and NrfG catalyzes the insertion of heme into cytochrome c552; heme lyase subunit NrfE 4272103 nrfE 8178050 nrfE Escherichia coli B str. REL606 heme lyase subunit NrfE YP_003047117.1 4270445 D 413997 CDS YP_003047118.1 254164010 8179345 4272096..4272479 1 NC_012967.1 similar to b4075; formate-dependent nitrite reductase complex subunit NrfF 4272479 nrfF 8179345 nrfF Escherichia coli B str. REL606 formate-dependent nitrite reductase complex subunit NrfF YP_003047118.1 4272096 D 413997 CDS YP_003047119.1 254164011 8178051 4272476..4273072 1 NC_012967.1 similar to b4076; formate-dependent nitrite reductase complex subunit NrfG 4273072 nrfG 8178051 nrfG Escherichia coli B str. REL606 formate-dependent nitrite reductase complex subunit NrfG YP_003047119.1 4272476 D 413997 CDS YP_003047120.1 254164012 8179346 4273414..4274727 1 NC_012967.1 carrier protein part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system; glutamate/aspartate:proton symporter 4274727 gltP 8179346 gltP Escherichia coli B str. REL606 glutamate/aspartate:proton symporter YP_003047120.1 4273414 D 413997 CDS YP_003047121.1 254164013 8178052 complement(4275258..4275947) 1 NC_012967.1 similar to b4078; hypothetical protein 4275947 yjcO 8178052 yjcO Escherichia coli B str. REL606 hypothetical protein YP_003047121.1 4275258 R 413997 CDS YP_003047122.1 254164014 8178053 complement(4276041..4278188) 1 NC_012967.1 similar to b4079; selenocysteine; formate dehydrogenase-H, selenopolypeptide subunit 4278188 fdhF 8178053 fdhF Escherichia coli B str. REL606 formate dehydrogenase-H, selenopolypeptide subunit YP_003047122.1 4276041 R 413997 CDS YP_003047123.1 254164015 8178054 complement(4278386..4279852) 1 NC_012967.1 part of a multidrug efflux system involved in resistance to acriflavin, puromycin, erytjhromycin and tetraphenylarsonium chloride; member of the outer membrane factor (OMF) family; putative outer membrane efflux protein MdtP 4279852 yjcP 8178054 yjcP Escherichia coli B str. REL606 putative outer membrane efflux protein MdtP YP_003047123.1 4278386 R 413997 CDS YP_003047124.1 254164016 8178055 complement(4279849..4281900) 1 NC_012967.1 possibly part of a tripartite efflux system composed of MdtN, MdtO and MdtP which could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug efflux system protein MdtO 4281900 yjcQ 8178055 yjcQ Escherichia coli B str. REL606 multidrug efflux system protein MdtO YP_003047124.1 4279849 R 413997 CDS YP_003047125.1 254164017 8178056 complement(4281900..4282931) 1 NC_012967.1 with MdtO and MdtP is involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug resistance protein MdtN 4282931 yjcR 8178056 yjcR Escherichia coli B str. REL606 multidrug resistance protein MdtN YP_003047125.1 4281900 R 413997 CDS YP_003047126.1 254164018 8178813 complement(4283434..4285419) 1 NC_012967.1 similar to b4083; putative alkyl sulfatase 4285419 yjcS 8178813 yjcS Escherichia coli B str. REL606 putative alkyl sulfatase YP_003047126.1 4283434 R 413997 CDS YP_003047127.1 254164019 8178057 complement(4285692..4286621) 1 NC_012967.1 similar to b4084; D-allose kinase 4286621 alsK 8178057 alsK Escherichia coli B str. REL606 D-allose kinase YP_003047127.1 4285692 R 413997 CDS YP_003047128.1 254164020 8178058 complement(4286605..4287300) 1 NC_012967.1 similar to b4085; allulose-6-phosphate 3-epimerase 4287300 alsE 8178058 alsE Escherichia coli B str. REL606 allulose-6-phosphate 3-epimerase YP_003047128.1 4286605 R 413997 CDS YP_003047129.1 254164021 8178059 complement(4287311..4288291) 1 NC_012967.1 similar to b4086; D-allose transporter subunit 4288291 alsC 8178059 alsC Escherichia coli B str. REL606 D-allose transporter subunit YP_003047129.1 4287311 R 413997 CDS YP_003047130.1 254164022 8178060 complement(4288270..4289802) 1 NC_012967.1 with AlsBC acts to import allose into the cell; AlsA contain 2 ATP-binding domains; D-allose transporter ATP-binding protein 4289802 alsA 8178060 alsA Escherichia coli B str. REL606 D-allose transporter ATP-binding protein YP_003047130.1 4288270 R 413997 CDS YP_003047131.1 254164023 8178814 complement(4289929..4290864) 1 NC_012967.1 similar to b4088; D-allose transporter subunit 4290864 alsB 8178814 alsB Escherichia coli B str. REL606 D-allose transporter subunit YP_003047131.1 4289929 R 413997 CDS YP_003047132.1 254164024 8178061 complement(4290923..4291813) 1 NC_012967.1 involved in rpiB and als operon repression; DNA-binding transcriptional repressor RpiR 4291813 rpiR 8178061 rpiR Escherichia coli B str. REL606 DNA-binding transcriptional repressor RpiR YP_003047132.1 4290923 R 413997 CDS YP_003047133.1 254164025 8178062 4292172..4292621 1 NC_012967.1 catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity; ribose-5-phosphate isomerase B 4292621 rpiB 8178062 rpiB Escherichia coli B str. REL606 ribose-5-phosphate isomerase B YP_003047133.1 4292172 D 413997 CDS YP_003047134.1 254164026 8178063 4292690..4293019 1 NC_012967.1 similar to b4487; hypothetical protein 4293019 yjdP 8178063 yjdP Escherichia coli B str. REL606 hypothetical protein YP_003047134.1 4292690 D 413997 CDS YP_003047135.1 254164027 8179347 complement(4293166..4293924) 1 NC_012967.1 required for the use of phosphonates and phosphite as phosphorus sources; carbon-phosphorus lyase complex accessory protein 4293924 phnP 8179347 phnP Escherichia coli B str. REL606 carbon-phosphorus lyase complex accessory protein YP_003047135.1 4293166 R 413997 CDS YP_003047136.1 254164028 8178064 complement(4293926..4294360) 1 NC_012967.1 PhnO in Salmonella enterica catalyzes the acetylation of a range of aminoalkylphosphonic acids; part of the biochemical pathway that enables the cell to use phosphonates as a phosphorus source; Escherichia coli uses a different mechanism of phosphonate catabolism where PhnO is not essential and seems to play a regulatory role; aminoalkylphosphonic acid N-acetyltransferase 4294360 phnO 8178064 phnO Escherichia coli B str. REL606 aminoalkylphosphonic acid N-acetyltransferase YP_003047136.1 4293926 R 413997 CDS YP_003047137.1 254164029 8178065 complement(4294347..4294904) 1 NC_012967.1 similar to b4094; ribose 1,5-bisphosphokinase 4294904 phnN 8178065 phnN Escherichia coli B str. REL606 ribose 1,5-bisphosphokinase YP_003047137.1 4294347 R 413997 CDS YP_003047138.1 254164030 8178066 complement(4294904..4296040) 1 NC_012967.1 similar to b4095; carbon-phosphorus lyase complex subunit 4296040 phnM 8178066 phnM Escherichia coli B str. REL606 carbon-phosphorus lyase complex subunit YP_003047138.1 4294904 R 413997 CDS YP_003047139.1 254164031 8178067 complement(4296037..4296717) 1 NC_012967.1 similar to b4096; carbon-phosphorus lyase complex subunit 4296717 phnL 8178067 phnL Escherichia coli B str. REL606 carbon-phosphorus lyase complex subunit YP_003047139.1 4296037 R 413997 CDS YP_003047140.1 254164032 8179348 complement(4296828..4297586) 1 NC_012967.1 similar to b4097; phosphonate C-P lyase system protein PhnK 4297586 phnK 8179348 phnK Escherichia coli B str. REL606 phosphonate C-P lyase system protein PhnK YP_003047140.1 4296828 R 413997 CDS YP_003047141.1 254164033 8178068 complement(4297583..4298428) 1 NC_012967.1 similar to b4098; carbon-phosphorus lyase complex subunit 4298428 phnJ 8178068 phnJ Escherichia coli B str. REL606 carbon-phosphorus lyase complex subunit YP_003047141.1 4297583 R 413997 CDS YP_003047142.1 254164034 8178069 complement(4298421..4299485) 1 NC_012967.1 similar to b4099; carbon-phosphorus lyase complex subunit 4299485 phnI 8178069 phnI Escherichia coli B str. REL606 carbon-phosphorus lyase complex subunit YP_003047142.1 4298421 R 413997 CDS YP_003047143.1 254164035 8178070 complement(4299485..4300069) 1 NC_012967.1 similar to b4100; carbon-phosphorus lyase complex subunit 4300069 phnH 8178070 phnH Escherichia coli B str. REL606 carbon-phosphorus lyase complex subunit YP_003047143.1 4299485 R 413997 CDS YP_003047144.1 254164036 8178071 complement(4300066..4300518) 1 NC_012967.1 similar to b4101; carbon-phosphorus lyase complex subunit 4300518 phnG 8178071 phnG Escherichia coli B str. REL606 carbon-phosphorus lyase complex subunit YP_003047144.1 4300066 R 413997 CDS YP_003047145.1 254164037 8178815 complement(4300519..4301244) 1 NC_012967.1 may be involved in phosphonate uptake and biodegradation; phosphonate metabolism transcriptional regulator PhnF 4301244 phnF 8178815 phnF Escherichia coli B str. REL606 phosphonate metabolism transcriptional regulator PhnF YP_003047145.1 4300519 R 413997 CDS YP_003047146.1 254164038 8178072 complement(4301265..4302083) 1 NC_012967.1 similar to b4103-b4104; phosphonate/organophosphate ester transporter 4302083 phnE 8178072 phnE Escherichia coli B str. REL606 phosphonate/organophosphate ester transporter YP_003047146.1 4301265 R 413997 CDS YP_003047147.1 254164039 8178073 complement(4302150..4303166) 1 NC_012967.1 similar to b4105; phosphonate/organophosphate ester transporter subunit 4303166 phnD 8178073 phnD Escherichia coli B str. REL606 phosphonate/organophosphate ester transporter subunit YP_003047147.1 4302150 R 413997 CDS YP_003047148.1 254164040 8178816 complement(4303191..4303979) 1 NC_012967.1 similar to b4106; phosphonate/organophosphate ester transporter subunit 4303979 phnC 8178816 phnC Escherichia coli B str. REL606 phosphonate/organophosphate ester transporter subunit YP_003047148.1 4303191 R 413997 CDS YP_003047149.1 254164041 8178074 complement(4304112..4304555) 1 NC_012967.1 similar to b4107; hypothetical protein 4304555 phnB 8178074 phnB Escherichia coli B str. REL606 hypothetical protein YP_003047149.1 4304112 R 413997 CDS YP_003047150.1 254164042 8178817 complement(4305113..4305448) 1 NC_012967.1 similar to b4108; hypothetical protein 4305448 phnA 8178817 phnA Escherichia coli B str. REL606 hypothetical protein YP_003047150.1 4305113 R 413997 CDS YP_003047151.1 254164043 8178075 4305849..4308077 1 NC_012967.1 similar to b4109; hypothetical protein 4308077 yjdA 8178075 yjdA Escherichia coli B str. REL606 hypothetical protein YP_003047151.1 4305849 D 413997 CDS YP_003047152.1 254164044 8178076 4308074..4308952 1 NC_012967.1 similar to b4110; hypothetical protein 4308952 yjcZ 8178076 yjcZ Escherichia coli B str. REL606 hypothetical protein YP_003047152.1 4308074 D 413997 CDS YP_003047153.1 254164045 8178077 4309216..4310718 1 NC_012967.1 similar to b4111; proline/glycine betaine transporter 4310718 proP 8178077 proP Escherichia coli B str. REL606 proline/glycine betaine transporter YP_003047153.1 4309216 D 413997 CDS YP_003047154.1 254164046 8178078 complement(4310895..4311986) 1 NC_012967.1 similar to b4112; sensor protein BasS/PmrB 4311986 basS 8178078 basS Escherichia coli B str. REL606 sensor protein BasS/PmrB YP_003047154.1 4310895 R 413997 CDS YP_003047155.1 254164047 8179349 complement(4311996..4312664) 1 NC_012967.1 response regulator in two-component regulatory system with BasS; DNA-binding transcriptional regulator BasR 4312664 basR 8179349 basR Escherichia coli B str. REL606 DNA-binding transcriptional regulator BasR YP_003047155.1 4311996 R 413997 CDS YP_003047156.1 254164048 8178079 complement(4312661..4314304) 1 NC_012967.1 with ZipA and an unidentified 24 kDa protein forms a complex involved in cell division; putative cell division protein 4314304 yjdB 8178079 yjdB Escherichia coli B str. REL606 putative cell division protein YP_003047156.1 4312661 R 413997 CDS YP_003047157.1 254164049 8178080 complement(4314408..4315745) 1 NC_012967.1 similar to b4115; arginine:agmatin antiporter 4315745 yjdE 8178080 yjdE Escherichia coli B str. REL606 arginine:agmatin antiporter YP_003047157.1 4314408 R 413997 CDS YP_003047158.1 254164050 8178081 complement(4315882..4316643) 1 NC_012967.1 similar to b4116; DNA-binding transcriptional activator 4316643 adiY 8178081 adiY Escherichia coli B str. REL606 DNA-binding transcriptional activator YP_003047158.1 4315882 R 413997 CDS YP_003047159.1 254164051 8178082 complement(4316968..4319238) 1 NC_012967.1 similar to b4117; biodegradative arginine decarboxylase 4319238 adiA 8178082 adiA Escherichia coli B str. REL606 biodegradative arginine decarboxylase YP_003047159.1 4316968 R 413997 CDS YP_003047160.1 254164052 8179350 complement(4319434..4320342) 1 NC_012967.1 similar to b4118; DNA-binding transcriptional regulator MelR 4320342 melR 8179350 melR Escherichia coli B str. REL606 DNA-binding transcriptional regulator MelR YP_003047160.1 4319434 R 413997 CDS YP_003047161.1 254164053 8178083 4320625..4321980 1 NC_012967.1 similar to b4119; alpha-galactosidase 4321980 melA 8178083 melA Escherichia coli B str. REL606 alpha-galactosidase YP_003047161.1 4320625 D 413997 CDS YP_003047162.1 254164054 8178084 4322095..4323504 1 NC_012967.1 similar to b4120; melibiose:sodium symporter 4323504 melB 8178084 melB Escherichia coli B str. REL606 melibiose:sodium symporter YP_003047162.1 4322095 D 413997 CDS YP_003047163.1 254164055 8178085 complement(4323643..4324272) 1 NC_012967.1 similar to b4121; hypothetical protein 4324272 yjdF 8178085 yjdF Escherichia coli B str. REL606 hypothetical protein YP_003047163.1 4323643 R 413997 CDS YP_003047164.1 254164056 8178086 complement(4324395..4326041) 1 NC_012967.1 similar to b4122; anaerobic class I fumarate hydratase (fumarase B) 4326041 fumB 8178086 fumB Escherichia coli B str. REL606 anaerobic class I fumarate hydratase (fumarase B) YP_003047164.1 4324395 R 413997 CDS YP_003047165.1 254164057 8178818 complement(4326119..4327459) 1 NC_012967.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters; anaerobic C4-dicarboxylate transporter 4327459 dcuB 8178818 dcuB Escherichia coli B str. REL606 anaerobic C4-dicarboxylate transporter YP_003047165.1 4326119 R 413997 CDS YP_003047166.1 254164058 8178087 complement(4328030..4328749) 1 NC_012967.1 response regulator in two-component regulatory system with DcuS; phosphorylated DcuR activates transcription of genes involved in anaerobic fumarate respiration; DNA-binding transcriptional activator DcuR 4328749 dcuR 8178087 dcuR Escherichia coli B str. REL606 DNA-binding transcriptional activator DcuR YP_003047166.1 4328030 R 413997 CDS YP_003047167.1 254164059 8178819 4330563..4330793 1 NC_012967.1 similar to b4126; hypothetical protein 4330793 yjdI 8178819 yjdI Escherichia coli B str. REL606 hypothetical protein YP_003047167.1 4330563 D 413997 CDS YP_003047168.1 254164060 8178089 4330805..4331077 1 NC_012967.1 similar to b4127; putative acyltransferase with acyl-CoA N-acyltransferase domain 4331077 yjdJ 8178089 yjdJ Escherichia coli B str. REL606 putative acyltransferase with acyl-CoA N-acyltransferase domain YP_003047168.1 4330805 D 413997 CDS YP_003047169.1 254164061 8178820 4331304..4331600 1 NC_012967.1 similar to b4128; hypothetical protein 4331600 yjdK 8178820 yjdK Escherichia coli B str. REL606 hypothetical protein YP_003047169.1 4331304 D 413997 CDS YP_003047170.1 254164062 8178090 complement(4331920..4333437) 1 NC_012967.1 class II; inducible; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; induced by high temperature, anaerobiosis, and low pH; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 4333437 lysU 8178090 lysU Escherichia coli B str. REL606 lysyl-tRNA synthetase YP_003047170.1 4331920 R 413997 CDS YP_003047171.1 254164063 8178091 complement(4333674..4335131) 1 NC_012967.1 similar to b4130; putative transporter 4335131 yjdL 8178091 yjdL Escherichia coli B str. REL606 putative transporter YP_003047171.1 4333674 R 413997 CDS YP_003047172.1 254164064 8178092 complement(4335190..4337337) 1 NC_012967.1 similar to b4131; lysine decarboxylase 1 4337337 cadA 8178092 cadA Escherichia coli B str. REL606 lysine decarboxylase 1 YP_003047172.1 4335190 R 413997 CDS YP_003047173.1 254164065 8178093 complement(4337417..4338751) 1 NC_012967.1 antiporter protein responsible for lysine import and cadaverine export; member of the lysine-dependent acid resistance system 4 (AR4); inner membrane protein; lysine/cadaverine antiporter 4338751 cadB 8178093 cadB Escherichia coli B str. REL606 lysine/cadaverine antiporter YP_003047173.1 4337417 R 413997 CDS YP_003047174.1 254164066 8179351 complement(4339117..4340655) 1 NC_012967.1 regulates the cadBA operon; DNA-binding transcriptional activator CadC 4340655 cadC 8179351 cadC Escherichia coli B str. REL606 DNA-binding transcriptional activator CadC YP_003047174.1 4339117 R 413997 CDS YP_003047175.1 254164067 8179352 complement(4341454..4342029) 1 NC_012967.1 similar to b4135; putative transcriptional regulator 4342029 yjdC 8179352 yjdC Escherichia coli B str. REL606 putative transcriptional regulator YP_003047175.1 4341454 R 413997 CDS YP_003047176.1 254164068 8178095 complement(4342066..4343763) 1 NC_012967.1 two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm; thiol:disulfide interchange protein precursor 4343763 dipZ 8178095 dipZ Escherichia coli B str. REL606 thiol:disulfide interchange protein precursor YP_003047176.1 4342066 R 413997 CDS YP_003047177.1 254164069 8178096 complement(4343739..4344077) 1 NC_012967.1 copper binding protein required for copper tolerance; involved in resistance toward heavy metals; divalent-cation tolerance protein CutA 4344077 cutA 8178096 cutA Escherichia coli B str. REL606 divalent-cation tolerance protein CutA YP_003047177.1 4343739 R 413997 CDS YP_003047178.1 254164070 8179353 complement(4344193..4345494) 1 NC_012967.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB; anaerobic C4-dicarboxylate transporter 4345494 dcuA 8179353 dcuA Escherichia coli B str. REL606 anaerobic C4-dicarboxylate transporter YP_003047178.1 4344193 R 413997 CDS YP_003047179.1 254164071 8178097 complement(4345612..4347048) 1 NC_012967.1 catalyzes the formation of fumarate from aspartate; aspartate ammonia-lyase 4347048 aspA 8178097 aspA Escherichia coli B str. REL606 aspartate ammonia-lyase YP_003047179.1 4345612 R 413997 CDS YP_003047180.1 254164072 8178098 4347385..4347861 1 NC_012967.1 F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein; FxsA 4347861 fxsA 8178098 fxsA Escherichia coli B str. REL606 FxsA YP_003047180.1 4347385 D 413997 CDS YP_003047181.1 254164073 8178099 complement(4347877..4349133) 1 NC_012967.1 uncharacterized member of the APC superfamily of amino acid transporters; unknown function; inner membrane protein YjeH 4349133 yjeH 8178099 yjeH Escherichia coli B str. REL606 inner membrane protein YjeH YP_003047181.1 4347877 R 413997 CDS YP_003047182.1 254164074 8178100 4349409..4349702 1 NC_012967.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 4349702 groES 8178100 groES Escherichia coli B str. REL606 co-chaperonin GroES YP_003047182.1 4349409 D 413997 CDS YP_003047183.1 254164075 8178821 4349746..4351392 1 NC_012967.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL 4351392 groEL 8178821 groEL Escherichia coli B str. REL606 chaperonin GroEL YP_003047183.1 4349746 D 413997 CDS YP_003047184.1 254164076 8178101 4351530..4351883 1 NC_012967.1 similar to b4144; hypothetical protein 4351883 yjeI 8178101 yjeI Escherichia coli B str. REL606 hypothetical protein YP_003047184.1 4351530 D 413997 CDS YP_003047185.1 254164077 8178102 complement(4352076..4352945) 1 NC_012967.1 similar to b4145; hypothetical protein 4352945 yjeJ 8178102 yjeJ Escherichia coli B str. REL606 hypothetical protein YP_003047185.1 4352076 R 413997 CDS YP_003047186.1 254164078 8178103 complement(4353340..4354368) 1 NC_012967.1 similar to b4146; putative lysine aminomutase 4354368 yjeK 8178103 yjeK Escherichia coli B str. REL606 putative lysine aminomutase YP_003047186.1 4353340 R 413997 CDS YP_003047187.1 254164079 8178104 4354410..4354976 1 NC_012967.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 4354976 efp 8178104 efp Escherichia coli B str. REL606 elongation factor P YP_003047187.1 4354410 D 413997 CDS YP_003047188.1 254164080 8178822 4355028..4355153 1 NC_012967.1 acts as and antidote to the bacteriolytic entericidin B in the EcnAB toxin-antitoxin complex; entericidin A 4355153 ecnA 8178822 ecnA Escherichia coli B str. REL606 entericidin A YP_003047188.1 4355028 D 413997 CDS YP_003047189.1 254164081 8178105 4355264..4355410 1 NC_012967.1 similar to b4411; entericidin B membrane lipoprotein 4355410 ecnB 8178105 ecnB Escherichia coli B str. REL606 entericidin B membrane lipoprotein YP_003047189.1 4355264 D 413997 CDS YP_003047190.1 254164082 8178106 4355586..4355903 1 NC_012967.1 member of the SMR family of proton-dependent drug efflux transporters; quaternary ammonium compound efflux pump; confers resistance to cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations; quaternary ammonium compound-resistance protein SugE 4355903 sugE 8178106 sugE Escherichia coli B str. REL606 quaternary ammonium compound-resistance protein SugE YP_003047190.1 4355586 D 413997 CDS YP_003047191.1 254164083 8178107 complement(4355897..4356433) 1 NC_012967.1 lipocalin; globomycin-sensitive outer membrane lipoprotein; outer membrane lipoprotein Blc 4356433 blc 8178107 blc Escherichia coli B str. REL606 outer membrane lipoprotein Blc YP_003047191.1 4355897 R 413997 CDS YP_003047192.1 254164084 8178108 complement(4356522..4357655) 1 NC_012967.1 similar to b4150; beta-lactamase 4357655 ampC 8178108 ampC Escherichia coli B str. REL606 beta-lactamase YP_003047192.1 4356522 R 413997 CDS YP_003047193.1 254164085 8179354 complement(4357718..4358077) 1 NC_012967.1 in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane; fumarate reductase subunit D 4358077 frdD 8179354 frdD Escherichia coli B str. REL606 fumarate reductase subunit D YP_003047193.1 4357718 R 413997 CDS YP_003047194.1 254164086 8178109 complement(4358088..4358483) 1 NC_012967.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase subunit C 4358483 frdC 8178109 frdC Escherichia coli B str. REL606 fumarate reductase subunit C YP_003047194.1 4358088 R 413997 CDS YP_003047195.1 254164087 8178110 complement(4358494..4359228) 1 NC_012967.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase iron-sulfur subunit 4359228 frdB 8178110 frdB Escherichia coli B str. REL606 fumarate reductase iron-sulfur subunit YP_003047195.1 4358494 R 413997 CDS YP_003047196.1 254164088 8178111 complement(4359221..4361029) 1 NC_012967.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase flavoprotein subunit 4361029 frdA 8178111 frdA Escherichia coli B str. REL606 fumarate reductase flavoprotein subunit YP_003047196.1 4359221 R 413997 CDS YP_003047197.1 254164089 8178112 4361354..4362331 1 NC_012967.1 lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase 4362331 yjeA 8178112 yjeA Escherichia coli B str. REL606 lysyl-tRNA synthetase YP_003047197.1 4361354 D 413997 CDS YP_003047198.1 254164090 8178113 4362550..4364052 1 NC_012967.1 similar to b4156; putative transporter 4364052 yjeM 8178113 yjeM Escherichia coli B str. REL606 putative transporter YP_003047198.1 4362550 D 413997 CDS YP_003047199.1 254164091 8178114 complement(4364202..4367525) 1 NC_012967.1 similar to b4159; hypothetical protein 4367525 yjeP 8178114 yjeP Escherichia coli B str. REL606 hypothetical protein YP_003047199.1 4364202 R 413997 CDS YP_003047200.1 254164092 8178823 complement(4367547..4368515) 1 NC_012967.1 catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine; phosphatidylserine decarboxylase 4368515 psd 8178823 psd Escherichia coli B str. REL606 phosphatidylserine decarboxylase YP_003047200.1 4367547 R 413997 CDS YP_003047201.1 254164093 8178115 complement(4368612..4369664) 1 NC_012967.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase 4369664 yjeQ 8178115 yjeQ Escherichia coli B str. REL606 ribosome-associated GTPase YP_003047201.1 4368612 R 413997 CDS YP_003047202.1 254164094 8178116 4369759..4370304 1 NC_012967.1 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 4370304 orn 8178116 orn Escherichia coli B str. REL606 oligoribonuclease YP_003047202.1 4369759 D 413997 CDS YP_003047203.1 254164095 8178120 complement(4371083..4372222) 1 NC_012967.1 similar to b4166; putative Fe-S electron transport protein 4372222 yjeS 8178120 yjeS Escherichia coli B str. REL606 putative Fe-S electron transport protein YP_003047203.1 4371083 R 413997 CDS YP_003047204.1 254164096 8178121 4372221..4373768 1 NC_012967.1 similar to b4167; hypothetical protein 4373768 yjeF 8178121 yjeF Escherichia coli B str. REL606 hypothetical protein YP_003047204.1 4372221 D 413997 CDS YP_003047205.1 254164097 8179355 4373740..4374201 1 NC_012967.1 possibly involved in cell wall synthesis; putative ATPase 4374201 yjeE 8179355 yjeE Escherichia coli B str. REL606 putative ATPase YP_003047205.1 4373740 D 413997 CDS YP_003047206.1 254164098 8178122 4374220..4375557 1 NC_012967.1 similar to b4169; N-acetylmuramoyl-l-alanine amidase II 4375557 amiB 8178122 amiB Escherichia coli B str. REL606 N-acetylmuramoyl-l-alanine amidase II YP_003047206.1 4374220 D 413997 CDS YP_003047207.1 254164099 8178123 4375567..4377414 1 NC_012967.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 4377414 mutL 8178123 mutL Escherichia coli B str. REL606 DNA mismatch repair protein YP_003047207.1 4375567 D 413997 CDS YP_003047208.1 254164100 8178824 4377407..4378357 1 NC_012967.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 4378357 miaA 8178824 miaA Escherichia coli B str. REL606 tRNA delta(2)-isopentenylpyrophosphate transferase YP_003047208.1 4377407 D 413997 CDS YP_003047209.1 254164101 8178124 4378443..4378751 1 NC_012967.1 Stimulates the elongation of poly(A) tails; RNA-binding protein Hfq 4378751 hfq 8178124 hfq Escherichia coli B str. REL606 RNA-binding protein Hfq YP_003047209.1 4378443 D 413997 CDS YP_003047210.1 254164102 8178125 4378827..4380107 1 NC_012967.1 involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein; putative GTPase HflX 4380107 hflX 8178125 hflX Escherichia coli B str. REL606 putative GTPase HflX YP_003047210.1 4378827 D 413997 CDS YP_003047211.1 254164103 8178126 4380193..4381452 1 NC_012967.1 with HflC inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflK 4381452 hflK 8178126 hflK Escherichia coli B str. REL606 FtsH protease regulator HflK YP_003047211.1 4380193 D 413997 CDS YP_003047212.1 254164104 8178127 4381455..4382459 1 NC_012967.1 with HflK inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflC 4382459 hflC 8178127 hflC Escherichia coli B str. REL606 FtsH protease regulator HflC YP_003047212.1 4381455 D 413997 CDS YP_003047213.1 254164105 8178128 4382541..4382738 1 NC_012967.1 similar to b4176; inner membrane protein 4382738 yjeT 8178128 yjeT Escherichia coli B str. REL606 inner membrane protein YP_003047213.1 4382541 D 413997 CDS YP_003047214.1 254164106 8178129 4382842..4384140 1 NC_012967.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 4384140 purA 8178129 purA Escherichia coli B str. REL606 adenylosuccinate synthetase YP_003047214.1 4382842 D 413997 CDS YP_003047215.1 254164107 8178130 4384345..4384770 1 NC_012967.1 negatively regulates the transcription of genes upregulated by nitrosative stress; transcriptional repressor NsrR 4384770 yjeB 8178130 yjeB Escherichia coli B str. REL606 transcriptional repressor NsrR YP_003047215.1 4384345 D 413997 CDS YP_003047216.1 254164108 8178131 4384809..4387250 1 NC_012967.1 3'-5'exoribonuclease that acts nonspecifically on poly(A), poly(U) and ribosomal RNAs; exoribonuclease R 4387250 rnr 8178131 rnr Escherichia coli B str. REL606 exoribonuclease R YP_003047216.1 4384809 D 413997 CDS YP_003047217.1 254164109 8178132 4387430..4388161 1 NC_012967.1 Specifically methylates the ribose of guanosine 2251 in 23S rRNA; 23S rRNA (guanosine-2'-O-)-methyltransferase 4388161 yjfH 8178132 yjfH Escherichia coli B str. REL606 23S rRNA (guanosine-2'-O-)-methyltransferase YP_003047217.1 4387430 D 413997 CDS YP_003047218.1 254164110 8179356 4388288..4388689 1 NC_012967.1 similar to b4181; hypothetical protein 4388689 yjfI 8179356 yjfI Escherichia coli B str. REL606 hypothetical protein YP_003047218.1 4388288 D 413997 CDS YP_003047219.1 254164111 8178133 4388708..4389406 1 NC_012967.1 similar to b4182; putative transcriptional regulator effector protein 4389406 yjfJ 8178133 yjfJ Escherichia coli B str. REL606 putative transcriptional regulator effector protein YP_003047219.1 4388708 D 413997 CDS YP_003047220.1 254164112 8178825 4389457..4390116 1 NC_012967.1 similar to b4183; hypothetical protein 4390116 yjfK 8178825 yjfK Escherichia coli B str. REL606 hypothetical protein YP_003047220.1 4389457 D 413997 CDS YP_003047221.1 254164113 8178134 4390134..4390532 1 NC_012967.1 similar to b4184; inner membrane protein 4390532 yjfL 8178134 yjfL Escherichia coli B str. REL606 inner membrane protein YP_003047221.1 4390134 D 413997 CDS YP_003047222.1 254164114 8178135 4390542..4391180 1 NC_012967.1 similar to b4185; hypothetical protein 4391180 yjfM 8178135 yjfM Escherichia coli B str. REL606 hypothetical protein YP_003047222.1 4390542 D 413997 CDS YP_003047223.1 254164115 8178826 4391183..4392346 1 NC_012967.1 similar to b4186; putative synthetase/amidase 4392346 yjfC 8178826 yjfC Escherichia coli B str. REL606 putative synthetase/amidase YP_003047223.1 4391183 D 413997 CDS YP_003047224.1 254164116 8178136 4392430..4394055 1 NC_012967.1 catalyzes the formation of 3-methylcrotonyl-CoA from isovaleryl-CoA; isovaleryl CoA dehydrogenase 4394055 aidB 8178136 aidB Escherichia coli B str. REL606 isovaleryl CoA dehydrogenase YP_003047224.1 4392430 D 413997 CDS YP_003047225.1 254164117 8178137 complement(4394172..4394447) 1 NC_012967.1 similar to b4188; hypothetical protein 4394447 yjfN 8178137 yjfN Escherichia coli B str. REL606 hypothetical protein YP_003047225.1 4394172 R 413997 CDS YP_003047226.1 254164118 8178827 complement(4394596..4394925) 1 NC_012967.1 in Escherichia coli, mutation of this gene affects biofilm maturation, stress response, and motility; putative biofilm stress and motility protein A 4394925 yjfO 8178827 yjfO Escherichia coli B str. REL606 putative biofilm stress and motility protein A YP_003047226.1 4394596 R 413997 CDS YP_003047227.1 254164119 8179357 4395107..4395856 1 NC_012967.1 YjfP; esterase activity towards palmitoyl-CoA and pNP-butyrate in vitro; unknown function and substrate in vivo; esterase 4395856 yjfP 8179357 yjfP Escherichia coli B str. REL606 esterase YP_003047227.1 4395107 D 413997 CDS YP_003047228.1 254164120 8178138 complement(4395853..4396608) 1 NC_012967.1 negative regulator of ulaG and ulaABCDEF; transcriptional repressor UlaR 4396608 yjfQ 8178138 yjfQ Escherichia coli B str. REL606 transcriptional repressor UlaR YP_003047228.1 4395853 R 413997 CDS YP_003047229.1 254164121 8178139 complement(4396716..4397780) 1 NC_012967.1 similar to b4192; putative L-ascorbate 6-phosphate lactonase 4397780 yjfR 8178139 yjfR Escherichia coli B str. REL606 putative L-ascorbate 6-phosphate lactonase YP_003047229.1 4396716 R 413997 CDS YP_003047230.1 254164122 8179358 4398135..4399532 1 NC_012967.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 4399532 ulaA 8179358 ulaA Escherichia coli B str. REL606 PTS system ascorbate-specific transporter subunit IIC YP_003047230.1 4398135 D 413997 CDS YP_003047231.1 254164123 8178140 4399548..4399853 1 NC_012967.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system L-ascorbate-specific transporter subunit IIB 4399853 sgaB 8178140 sgaB Escherichia coli B str. REL606 PTS system L-ascorbate-specific transporter subunit IIB YP_003047231.1 4399548 D 413997 CDS YP_003047232.1 254164124 8178141 4399863..4400327 1 NC_012967.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system L-ascorbate-specific transporter subunit IIA 4400327 ptxA 8178141 ptxA Escherichia coli B str. REL606 PTS system L-ascorbate-specific transporter subunit IIA YP_003047232.1 4399863 D 413997 CDS YP_003047233.1 254164125 8179359 4400341..4400991 1 NC_012967.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase 4400991 ulaD 8179359 ulaD Escherichia coli B str. REL606 3-keto-L-gulonate-6-phosphate decarboxylase YP_003047233.1 4400341 D 413997 CDS YP_003047234.1 254164126 8178142 4401001..4401855 1 NC_012967.1 UlaE; catalyzes the epimerization of L-ribulose-5-phosphate into L-xylulose-5-phosphate; part of the anaerobic L-ascorbate degradation pathway; L-xylulose 5-phosphate 3-epimerase 4401855 sgaU 8178142 sgaU Escherichia coli B str. REL606 L-xylulose 5-phosphate 3-epimerase YP_003047234.1 4401001 D 413997 CDS YP_003047235.1 254164127 8178143 4401855..4402541 1 NC_012967.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 4402541 sgaE 8178143 sgaE Escherichia coli B str. REL606 L-ribulose-5-phosphate 4-epimerase YP_003047235.1 4401855 D 413997 CDS YP_003047236.1 254164128 8178144 complement(4402670..4402945) 1 NC_012967.1 similar to b4199; hypothetical protein 4402945 yjfY 8178144 yjfY Escherichia coli B str. REL606 hypothetical protein YP_003047236.1 4402670 R 413997 CDS YP_003047237.1 254164129 8178145 4403273..4403668 1 NC_012967.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 4403668 rpsF 8178145 rpsF Escherichia coli B str. REL606 30S ribosomal protein S6 YP_003047237.1 4403273 D 413997 CDS YP_003047238.1 254164130 8178146 4403675..4403989 1 NC_012967.1 binds single-stranded DNA at the primosome assembly site; primosomal replication protein N 4403989 priB 8178146 priB Escherichia coli B str. REL606 primosomal replication protein N YP_003047238.1 4403675 D 413997 CDS YP_003047239.1 254164131 8178147 4403994..4404221 1 NC_012967.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 4404221 rpsR 8178147 rpsR Escherichia coli B str. REL606 30S ribosomal protein S18 YP_003047239.1 4403994 D 413997 CDS YP_003047240.1 254164132 8178148 4404263..4404712 1 NC_012967.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 4404712 rplI 8178148 rplI Escherichia coli B str. REL606 50S ribosomal protein L9 YP_003047240.1 4404263 D 413997 CDS YP_003047241.1 254164133 8178149 complement(4404814..4406091) 1 NC_012967.1 Hexuronate transporter 4406091 8178149 ECB_04071 Escherichia coli B str. REL606 Hexuronate transporter YP_003047241.1 4404814 R 413997 CDS YP_003047242.1 254164134 8179360 complement(4406184..4408256) 1 NC_012967.1 putative oxidoreductase 4408256 8179360 ECB_04072 Escherichia coli B str. REL606 putative oxidoreductase YP_003047242.1 4406184 R 413997 CDS YP_003047243.1 254164135 8178150 complement(4408253..4409794) 1 NC_012967.1 putative acetyl-CoA:acetoacetyl-CoA transferase 4409794 8178150 ECB_04073 Escherichia coli B str. REL606 putative acetyl-CoA:acetoacetyl-CoA transferase YP_003047243.1 4408253 R 413997 CDS YP_003047244.1 254164136 8179361 complement(4409804..4410580) 1 NC_012967.1 hypothetical protein 4410580 8179361 ECB_04074 Escherichia coli B str. REL606 hypothetical protein YP_003047244.1 4409804 R 413997 CDS YP_003047245.1 254164137 8178151 complement(4410590..4411432) 1 NC_012967.1 hypothetical protein 4411432 8178151 ECB_04075 Escherichia coli B str. REL606 hypothetical protein YP_003047245.1 4410590 R 413997 CDS YP_003047246.1 254164138 8178152 complement(4411442..4412233) 1 NC_012967.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-(acyl-carrier-protein) reductase 4412233 8178152 ECB_04076 Escherichia coli B str. REL606 3-ketoacyl-(acyl-carrier-protein) reductase YP_003047246.1 4411442 R 413997 CDS YP_003047247.1 254164139 8178828 4412767..4413093 1 NC_012967.1 similar to b4205; putative transcriptional regulator 4413093 ytfA 8178828 ytfA Escherichia coli B str. REL606 putative transcriptional regulator YP_003047247.1 4412767 D 413997 CDS YP_003047248.1 254164140 8178153 complement(4413077..4413715) 1 NC_012967.1 similar to b4206; putative cell envelope opacity-associated protein 4413715 ytfB 8178153 ytfB Escherichia coli B str. REL606 putative cell envelope opacity-associated protein YP_003047248.1 4413077 R 413997 CDS YP_003047249.1 254164141 8178154 4413934..4414554 1 NC_012967.1 FKBP-type; rotamase; catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; peptidyl-prolyl cis-trans isomerase 4414554 fklB 8178154 fklB Escherichia coli B str. REL606 peptidyl-prolyl cis-trans isomerase YP_003047249.1 4413934 D 413997 CDS YP_003047250.1 254164142 8178829 4414863..4416275 1 NC_012967.1 involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine; D-alanine/D-serine/glycine permease 4416275 cycA 8178829 cycA Escherichia coli B str. REL606 D-alanine/D-serine/glycine permease YP_003047250.1 4414863 D 413997 CDS YP_003047251.1 254164143 8178155 complement(4416320..4416982) 1 NC_012967.1 Involved in anaerobic NO protection and iron metabolism; iron-sulfur cluster repair di-iron protein 4416982 ytfE 8178155 ytfE Escherichia coli B str. REL606 iron-sulfur cluster repair di-iron protein YP_003047251.1 4416320 R 413997 CDS YP_003047252.1 254164144 8178156 complement(4417090..4418064) 1 NC_012967.1 similar to b4210; putative inner membrane protein 4418064 ytfF 8178156 ytfF Escherichia coli B str. REL606 putative inner membrane protein YP_003047252.1 4417090 R 413997 CDS YP_003047253.1 254164145 8178157 complement(4418164..4419024) 1 NC_012967.1 similar to b4211; NAD(P)H:quinone oxidoreductase 4419024 ytfG 8178157 ytfG Escherichia coli B str. REL606 NAD(P)H:quinone oxidoreductase YP_003047253.1 4418164 R 413997 CDS YP_003047254.1 254164146 8179362 4419113..4419493 1 NC_012967.1 similar to b4212; putative transcriptional regulator 4419493 ytfH 8179362 ytfH Escherichia coli B str. REL606 putative transcriptional regulator YP_003047254.1 4419113 D 413997 CDS YP_003047255.1 254164147 8178158 complement(4419616..4421559) 1 NC_012967.1 periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate; bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein 4421559 cpdB 8178158 cpdB Escherichia coli B str. REL606 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein YP_003047255.1 4419616 R 413997 CDS YP_003047256.1 254164148 8178159 4421749..4422489 1 NC_012967.1 catalyzes the formation of AMP from adenosine-3',5'-bisphosphate; adenosine-3'(2'),5'-bisphosphate nucleotidase 4422489 cysQ 8178159 cysQ Escherichia coli B str. REL606 adenosine-3'(2'),5'-bisphosphate nucleotidase YP_003047256.1 4421749 D 413997 CDS YP_003047257.1 254164149 8179363 complement(4422479..4423036) 1 NC_012967.1 similar to b4216; putative transcriptional regulator 4423036 ytfJ 8179363 ytfJ Escherichia coli B str. REL606 putative transcriptional regulator YP_003047257.1 4422479 R 413997 CDS YP_003047258.1 254164150 8178160 4423361..4423567 1 NC_012967.1 similar to b4217; hypothetical protein 4423567 ytfK 8178160 ytfK Escherichia coli B str. REL606 hypothetical protein YP_003047258.1 4423361 D 413997 CDS YP_003047259.1 254164151 8178830 complement(4423629..4424972) 1 NC_012967.1 similar to b4218; putative inner membrane protein 4424972 ytfL 8178830 ytfL Escherichia coli B str. REL606 putative inner membrane protein YP_003047259.1 4423629 R 413997 CDS YP_003047260.1 254164152 8178161 complement(4425295..4425933) 1 NC_012967.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A 4425933 msrA 8178161 msrA Escherichia coli B str. REL606 methionine sulfoxide reductase A YP_003047260.1 4425295 R 413997 CDS YP_003047261.1 254164153 8178162 4426139..4427872 1 NC_012967.1 similar to b4220; putative outer membrane protein and surface antigen 4427872 ytfM 8178162 ytfM Escherichia coli B str. REL606 putative outer membrane protein and surface antigen YP_003047261.1 4426139 D 413997 CDS YP_003047262.1 254164154 8178831 4427869..4431648 1 NC_012967.1 similar to b4221; hypothetical protein 4431648 ytfN 8178831 ytfN Escherichia coli B str. REL606 hypothetical protein YP_003047262.1 4427869 D 413997 CDS YP_003047265.1 254164155 8178163 complement(4432372..4432902) 1 NC_012967.1 catalyzes the hydrolysis of pyrophosphate to phosphate; inorganic pyrophosphatase 4432902 ppa 8178163 ppa Escherichia coli B str. REL606 inorganic pyrophosphatase YP_003047265.1 4432372 R 413997 CDS YP_003047266.1 254164156 8178164 4433212..4434168 1 NC_012967.1 similar to b4227; putative sugar transporter subunit periplasmic-binding component of ABC superfamily 4434168 ytfQ 8178164 ytfQ Escherichia coli B str. REL606 putative sugar transporter subunit periplasmic-binding component of ABC superfamily YP_003047266.1 4433212 D 413997 CDS YP_003047267.1 254164157 8178165 4434308..4435810 1 NC_012967.1 similar to b4485; putative sugar transporter subunit ATP-binding protein of ABC superfamily 4435810 ytfR 8178165 ytfR Escherichia coli B str. REL606 putative sugar transporter subunit ATP-binding protein of ABC superfamily YP_003047267.1 4434308 D 413997 CDS YP_003047268.1 254164158 8178166 4435824..4436846 1 NC_012967.1 similar to b4230; putative sugar transporter subunit membrane component of ABC superfamily 4436846 ytfT 8178166 ytfT Escherichia coli B str. REL606 putative sugar transporter subunit membrane component of ABC superfamily YP_003047268.1 4435824 D 413997 CDS YP_003047269.1 254164159 8179364 4436833..4437828 1 NC_012967.1 membrane component of a putative sugar ABC transporter system; inner membrane ABC transporter permease YjfF 4437828 yjfF 8179364 yjfF Escherichia coli B str. REL606 inner membrane ABC transporter permease YjfF YP_003047269.1 4436833 D 413997 CDS YP_003047270.1 254164160 8178167 complement(4437861..4438859) 1 NC_012967.1 catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate; fructose-1,6-bisphosphatase 4438859 fbp 8178167 fbp Escherichia coli B str. REL606 fructose-1,6-bisphosphatase YP_003047270.1 4437861 R 413997 CDS YP_003047271.1 254164161 8178168 4439035..4440408 1 NC_012967.1 similar to b4233; UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase 4440408 mpl 8178168 mpl Escherichia coli B str. REL606 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase YP_003047271.1 4439035 D 413997 CDS YP_003047272.1 254164162 8179365 complement(4440564..4441115) 1 NC_012967.1 similar to b4234; hypothetical protein 4441115 yjgA 8179365 yjgA Escherichia coli B str. REL606 hypothetical protein YP_003047272.1 4440564 R 413997 CDS YP_003047273.1 254164163 8178169 4441210..4442562 1 NC_012967.1 protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD; peptidase PmbA 4442562 pmbA 8178169 pmbA Escherichia coli B str. REL606 peptidase PmbA YP_003047273.1 4441210 D 413997 CDS YP_003047274.1 254164164 8178832 complement(4443176..4443640) 1 NC_012967.1 activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions; anaerobic ribonucleotide reductase-activating protein 4443640 nrdG 8178832 nrdG Escherichia coli B str. REL606 anaerobic ribonucleotide reductase-activating protein YP_003047274.1 4443176 R 413997 CDS YP_003047275.1 254164165 8178171 complement(4443799..4445937) 1 NC_012967.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase 4445937 nrdD 8178171 nrdD Escherichia coli B str. REL606 anaerobic ribonucleoside triphosphate reductase YP_003047275.1 4443799 R 413997 CDS YP_003047276.1 254164166 8178172 complement(4446331..4447986) 1 NC_012967.1 similar to b4239; trehalose-6-phosphate hydrolase 4447986 treC 8178172 treC Escherichia coli B str. REL606 trehalose-6-phosphate hydrolase YP_003047276.1 4446331 R 413997 CDS YP_003047277.1 254164167 8178833 complement(4448036..4449457) 1 NC_012967.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system trehalose(maltose)-specific transporter subunits IIBC 4449457 treB 8178833 treB Escherichia coli B str. REL606 PTS system trehalose(maltose)-specific transporter subunits IIBC YP_003047277.1 4448036 R 413997 CDS YP_003047278.1 254164168 8178173 complement(4449576..4450523) 1 NC_012967.1 regulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon; trehalose repressor 4450523 treR 8178173 treR Escherichia coli B str. REL606 trehalose repressor YP_003047278.1 4449576 R 413997 CDS YP_003047279.1 254164169 8179366 4450902..4453598 1 NC_012967.1 P-type ATPase involved in magnesium influx; magnesium-transporting ATPase MgtA 4453598 mgtA 8179366 mgtA Escherichia coli B str. REL606 magnesium-transporting ATPase MgtA YP_003047279.1 4450902 D 413997 CDS YP_003047280.1 254164170 8179367 complement(4453804..4454190) 1 NC_012967.1 similar to b4243; ketoacid-binding protein 4454190 yjgF 8179367 yjgF Escherichia coli B str. REL606 ketoacid-binding protein YP_003047280.1 4453804 R 413997 CDS YP_003047281.1 254164171 8178174 complement(4454263..4454724) 1 NC_012967.1 involved in the allosteric regulation of aspartate carbamoyltransferase; aspartate carbamoyltransferase regulatory subunit 4454724 pyrI 8178174 pyrI Escherichia coli B str. REL606 aspartate carbamoyltransferase regulatory subunit YP_003047281.1 4454263 R 413997 CDS YP_003047282.1 254164172 8178175 complement(4454737..4455672) 1 NC_012967.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase catalytic subunit 4455672 pyrB 8178175 pyrB Escherichia coli B str. REL606 aspartate carbamoyltransferase catalytic subunit YP_003047282.1 4454737 R 413997 CDS YP_003047283.1 254164173 8178176 complement(4455676..4455810) 1 NC_012967.1 similar to b4246; pyrBI operon leader peptide 4455810 pyrL 8178176 pyrL Escherichia coli B str. REL606 pyrBI operon leader peptide YP_003047283.1 4455676 R 413997 CDS YP_003047284.1 254164174 8178177 complement(4456091..4456486) 1 NC_012967.1 similar to b4248; putative mRNA endoribonuclease 4456486 yjgH 8178177 yjgH Escherichia coli B str. REL606 putative mRNA endoribonuclease YP_003047284.1 4456091 R 413997 CDS YP_003047285.1 254164175 8179368 complement(4456617..4457330) 1 NC_012967.1 similar to b4249; oxidoreductase 4457330 yjgI 8179368 yjgI Escherichia coli B str. REL606 oxidoreductase YP_003047285.1 4456617 R 413997 CDS YP_003047286.1 254164176 8178178 4457401..4457994 1 NC_012967.1 similar to b4251; putative transcriptional regulator 4457994 yjgJ 8178178 yjgJ Escherichia coli B str. REL606 putative transcriptional regulator YP_003047286.1 4457401 D 413997 CDS YP_003047287.1 254164177 8178179 4458139..4458591 1 NC_012967.1 similar to b4252; hypothetical protein 4458591 yjgK 8178179 yjgK Escherichia coli B str. REL606 hypothetical protein YP_003047287.1 4458139 D 413997 CDS YP_003047288.1 254164178 8178180 4458714..4460366 1 NC_012967.1 similar to b4253; hypothetical protein 4460366 yjgL 8178180 yjgL Escherichia coli B str. REL606 hypothetical protein YP_003047288.1 4458714 D 413997 CDS YP_003047289.1 254164179 8178834 complement(4460439..4461443) 1 NC_012967.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; E. coli K12 has two genes, argF and argI, capable of producing functional ornithine carbamoyltransferase. When both are active in the same cell, the two gene products form a family of four hybrid trimeric isoenzymes designated, FFF, FFI, FII, and III.; ornithine carbamoyltransferase subunit I 4461443 argI 8178834 argI Escherichia coli B str. REL606 ornithine carbamoyltransferase subunit I YP_003047289.1 4460439 R 413997 CDS YP_003047290.1 254164180 8178835 4461605..4462021 1 NC_012967.1 similar to b4255; hypothetical protein 4462021 yjgD 8178835 yjgD Escherichia coli B str. REL606 hypothetical protein YP_003047290.1 4461605 D 413997 CDS YP_003047291.1 254164181 8178181 complement(4462067..4462570) 1 NC_012967.1 similar to b4256; putative acetyltransferase 4462570 yjgM 8178181 yjgM Escherichia coli B str. REL606 putative acetyltransferase YP_003047291.1 4462067 R 413997 CDS YP_003047292.1 254164182 8178182 4462763..4463959 1 NC_012967.1 similar to b4257; inner membrane protein 4463959 yjgN 8178182 yjgN Escherichia coli B str. REL606 inner membrane protein YP_003047292.1 4462763 D 413997 CDS YP_003047293.1 254164183 8178183 complement(4464015..4466870) 1 NC_012967.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 4466870 valS 8178183 valS Escherichia coli B str. REL606 valyl-tRNA synthetase YP_003047293.1 4464015 R 413997 CDS YP_003047294.1 254164184 8178184 complement(4466870..4467313) 1 NC_012967.1 binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit chi 4467313 holC 8178184 holC Escherichia coli B str. REL606 DNA polymerase III subunit chi YP_003047294.1 4466870 R 413997 CDS YP_003047295.1 254164185 8178185 complement(4467667..4469178) 1 NC_012967.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase 4469178 pepA 8178185 pepA Escherichia coli B str. REL606 leucyl aminopeptidase YP_003047295.1 4467667 R 413997 CDS YP_003047296.1 254164186 8178186 4469445..4470545 1 NC_012967.1 similar to b4261; inner membrane protein 4470545 yjgP 8178186 yjgP Escherichia coli B str. REL606 inner membrane protein YP_003047296.1 4469445 D 413997 CDS YP_003047297.1 254164187 8178187 4470545..4471627 1 NC_012967.1 similar to b4262; inner membrane protein 4471627 yjgQ 8178187 yjgQ Escherichia coli B str. REL606 inner membrane protein YP_003047297.1 4470545 D 413997 CDS YP_003047298.1 254164188 8178188 complement(4471788..4473290) 1 NC_012967.1 similar to b4263; putative ATPase 4473290 yjgR 8178188 yjgR Escherichia coli B str. REL606 putative ATPase YP_003047298.1 4471788 R 413997 CDS YP_003047299.1 254164189 8178189 complement(4473368..4474366) 1 NC_012967.1 similar to b4264; DNA-binding transcriptional repressor, 5-gluconate-binding 4474366 idnR 8178189 idnR Escherichia coli B str. REL606 DNA-binding transcriptional repressor, 5-gluconate-binding YP_003047299.1 4473368 R 413997 CDS YP_003047300.1 254164190 8178836 complement(4474433..4475752) 1 NC_012967.1 similar to b4265; L-idonate and D-gluconate transporter 4475752 idnT 8178836 idnT Escherichia coli B str. REL606 L-idonate and D-gluconate transporter YP_003047300.1 4474433 R 413997 CDS YP_003047301.1 254164191 8178190 complement(4475815..4476579) 1 NC_012967.1 Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate; gluconate 5-dehydrogenase 4476579 idnO 8178190 idnO Escherichia coli B str. REL606 gluconate 5-dehydrogenase YP_003047301.1 4475815 R 413997 CDS YP_003047302.1 254164192 8178191 complement(4476603..4477634) 1 NC_012967.1 NAD-binding; L-idonate 5-dehydrogenase 4477634 idnD 8178191 idnD Escherichia coli B str. REL606 L-idonate 5-dehydrogenase YP_003047302.1 4476603 R 413997 CDS YP_003047303.1 254164193 8178837 4477851..4478414 1 NC_012967.1 similar to b4268; D-gluconate kinase 4478414 idnK 8178837 idnK Escherichia coli B str. REL606 D-gluconate kinase YP_003047303.1 4477851 D 413997 CDS YP_003047304.1 254164194 8179369 complement(4478418..4479437) 1 NC_012967.1 similar to b4269; putative alcohol dehydrogenase, Zn-dependent and NAD(P)-binding 4479437 yjgB 8179369 yjgB Escherichia coli B str. REL606 putative alcohol dehydrogenase, Zn-dependent and NAD(P)-binding YP_003047304.1 4478418 R 413997 CDS YP_003047305.1 254164195 8178193 4479978..4481168 1 NC_012967.1 similar to b4271; putative integrase 4481168 intB 8178193 intB Escherichia coli B str. REL606 putative integrase YP_003047305.1 4479978 D 413997 CDS YP_003047306.1 254164196 8178194 4481491..4481826 1 NC_012967.1 similar to b4274; hypothetical protein 4481826 yjgW 8178194 yjgW Escherichia coli B str. REL606 hypothetical protein YP_003047306.1 4481491 D 413997 CDS YP_003047307.1 254164197 8179370 4483152..4483481 1 NC_012967.1 similar to b4277; hypothetical protein 4483481 yjgZ 8179370 yjgZ Escherichia coli B str. REL606 hypothetical protein YP_003047307.1 4483152 D 413997 CDS YP_003047308.1 254164198 8178196 complement(4483995..4485323) 1 NC_012967.1 similar to b4278; IS4 putative transposase 4485323 insG 8178196 insG Escherichia coli B str. REL606 IS4 putative transposase YP_003047308.1 4483995 R 413997 CDS YP_003047309.1 254164199 8178197 4485950..4487167 1 NC_012967.1 similar to b4279; putative sialic acid transporter 4487167 yjhB 8178197 yjhB Escherichia coli B str. REL606 putative sialic acid transporter YP_003047309.1 4485950 D 413997 CDS YP_003047310.1 254164200 8178198 4487179..4488297 1 NC_012967.1 similar to b4280; putative oxidoreductase 4488297 yjhC 8178198 yjhC Escherichia coli B str. REL606 putative oxidoreductase YP_003047310.1 4487179 D 413997 CDS YP_003047311.1 254164201 8178199 4489089..4489361 1 NC_012967.1 IS911 protein 4489361 insN 8178199 insN Escherichia coli B str. REL606 IS911 protein YP_003047311.1 4489089 D 413997 CDS YP_003047312.1 254164202 8178200 4489417..4490256 1 NC_012967.1 IS911 orfA-like protein 4490256 8178200 ECB_04146 Escherichia coli B str. REL606 IS911 orfA-like protein YP_003047312.1 4489417 D 413997 CDS YP_003047313.1 254164203 8178201 4490372..4490635 1 NC_012967.1 hypothetical protein 4490635 8178201 ECB_04147 Escherichia coli B str. REL606 hypothetical protein YP_003047313.1 4490372 D 413997 CDS YP_003047314.1 254164204 8178202 complement(4490667..4492670) 1 NC_012967.1 secondary glycine betaine transporter BetU 4492670 8178202 ECB_04148 Escherichia coli B str. REL606 secondary glycine betaine transporter BetU YP_003047314.1 4490667 R 413997 CDS YP_003047315.1 254164205 8178203 complement(4492818..4493636) 1 NC_012967.1 IS600 ORF2-like protein 4493636 yis2 8178203 yis2 Escherichia coli B str. REL606 IS600 ORF2-like protein YP_003047315.1 4492818 R 413997 CDS YP_003047316.1 254164206 8178204 complement(4493672..4493974) 1 NC_012967.1 IS600 ORF1-like protein 4493974 yis1 8178204 yis1 Escherichia coli B str. REL606 IS600 ORF1-like protein YP_003047316.1 4493672 R 413997 CDS YP_003047317.1 254164207 8179371 4494752..4495165 1 NC_012967.1 similar to b4286; hypothetical protein 4495165 8179371 ECB_04152 Escherichia coli B str. REL606 hypothetical protein YP_003047317.1 4494752 D 413997 CDS YP_003047318.1 254164208 8178205 complement(4495722..4496489) 1 NC_012967.1 Part of the FecBCDE citrate-dependent iron (III) transport system; iron-dicitrate transporter ATP-binding subunit 4496489 fecE 8178205 fecE Escherichia coli B str. REL606 iron-dicitrate transporter ATP-binding subunit YP_003047318.1 4495722 R 413997 CDS YP_003047319.1 254164209 8178206 complement(4496490..4497446) 1 NC_012967.1 Ferric citrate binds FecA and is transported across the outer membrane while transmits a signal across the cytoplasmic membrane protein FecR. FecR transmits a signal across the membrane and activates the cytoplasmic FecI that directs the RNA polymerase to express the fecABCDE operon (which encodes the ferric citrate outer membrane receptor and the ferric citrate ABC transporter), as well as fecIR. FecD is one of two (along with FecC) integral membrane protein components of the iron dicitrate ABC transporter.; iron-dicitrate transporter subunit FecD 4497446 fecD 8178206 fecD Escherichia coli B str. REL606 iron-dicitrate transporter subunit FecD YP_003047319.1 4496490 R 413997 CDS YP_003047320.1 254164210 8178207 complement(4497443..4498441) 1 NC_012967.1 part of the FecBCDE citrate-dependent iron (III) transport system; iron-dicitrate transporter permease 4498441 fecC 8178207 fecC Escherichia coli B str. REL606 iron-dicitrate transporter permease YP_003047320.1 4497443 R 413997 CDS YP_003047321.1 254164211 8178208 complement(4498438..4499340) 1 NC_012967.1 part of the ABC transporter involved in the uptake of citrate-dependent Fe(3+); iron-dicitrate transporter substrate-binding subunit 4499340 fecB 8178208 fecB Escherichia coli B str. REL606 iron-dicitrate transporter substrate-binding subunit YP_003047321.1 4498438 R 413997 CDS YP_003047322.1 254164212 8178840 complement(4499385..4501709) 1 NC_012967.1 similar to b4291; ferric citrate outer membrane transporter 4501709 fecA 8178840 fecA Escherichia coli B str. REL606 ferric citrate outer membrane transporter YP_003047322.1 4499385 R 413997 CDS YP_003047323.1 254164213 8178209 complement(4501796..4502749) 1 NC_012967.1 with FecA forms the FecAR signal transduction system; ferric citrate binds FecA and transmits a signal across the outer membrane to FecR. FecR transmits a signal across the cytoplasmic membrane and activates the sigma 70 protein FecI that directs the RNA polymerase to express the fecABCDE operon; fec operon regulator FecR 4502749 fecR 8178209 fecR Escherichia coli B str. REL606 fec operon regulator FecR YP_003047323.1 4501796 R 413997 CDS YP_003047324.1 254164214 8178210 complement(4502746..4503267) 1 NC_012967.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor regulates the genes for iron dicitrate transport; RNA polymerase sigma factor FecI 4503267 fecI 8178210 fecI Escherichia coli B str. REL606 RNA polymerase sigma factor FecI YP_003047324.1 4502746 R 413997 CDS YP_003047325.1 254164215 8178211 4503559..4503834 1 NC_012967.1 IS1 protein InsA 4503834 insA-25 8178211 insA-25 Escherichia coli B str. REL606 IS1 protein InsA YP_003047325.1 4503559 D 413997 CDS YP_003047326.1 254164216 8179372 4504981..4505274 1 NC_012967.1 hypothetical protein 4505274 8179372 ECB_04162 Escherichia coli B str. REL606 hypothetical protein YP_003047326.1 4504981 D 413997 CDS YP_003047327.1 254164217 8179373 complement(4505357..4505860) 1 NC_012967.1 IS1 protein InsB 4505860 insB-26 8179373 insB-26 Escherichia coli B str. REL606 IS1 protein InsB YP_003047327.1 4505357 R 413997 CDS YP_003047328.1 254164218 8178213 complement(4505779..4506054) 1 NC_012967.1 IS1 protein InsA 4506054 insA-26 8178213 insA-26 Escherichia coli B str. REL606 IS1 protein InsA YP_003047328.1 4505779 R 413997 CDS YP_003047329.1 254164219 8178214 complement(4506244..4507026) 1 NC_012967.1 similar to b4300; putative DNA-binding transcriptional regulator 4507026 sgcR 8178214 sgcR Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003047329.1 4506244 R 413997 CDS YP_003047330.1 254164220 8178215 complement(4507043..4507675) 1 NC_012967.1 similar to b4301; epimerase 4507675 sgcE 8178215 sgcE Escherichia coli B str. REL606 epimerase YP_003047330.1 4507043 R 413997 CDS YP_003047331.1 254164221 8178216 complement(4507687..4508118) 1 NC_012967.1 similar to b4302; putative phosphotransferase enzyme IIA component 4508118 sgcA 8178216 sgcA Escherichia coli B str. REL606 putative phosphotransferase enzyme IIA component YP_003047331.1 4507687 R 413997 CDS YP_003047332.1 254164222 8178217 complement(4508249..4509055) 1 NC_012967.1 similar to b4303; putative nucleoside triphosphatase 4509055 sgcQ 8178217 sgcQ Escherichia coli B str. REL606 putative nucleoside triphosphatase YP_003047332.1 4508249 R 413997 CDS YP_003047333.1 254164223 8178841 complement(4509068..4510381) 1 NC_012967.1 similar to b4304; putative phosphotransferase enzyme IIC component 4510381 sgcC 8178841 sgcC Escherichia coli B str. REL606 putative phosphotransferase enzyme IIC component YP_003047333.1 4509068 R 413997 CDS YP_003047334.1 254164224 8178218 complement(4510393..4510671) 1 NC_012967.1 similar to b4565; putative PTS system transporter subunit IIB 4510671 sgcB 8178218 sgcB Escherichia coli B str. REL606 putative PTS system transporter subunit IIB YP_003047334.1 4510393 R 413997 CDS YP_003047335.1 254164225 8178219 complement(4510668..4511789) 1 NC_012967.1 similar to b4305; putative endoglucanase with Zn-dependent exopeptidase domain 4511789 sgcX 8178219 sgcX Escherichia coli B str. REL606 putative endoglucanase with Zn-dependent exopeptidase domain YP_003047335.1 4510668 R 413997 CDS YP_003047336.1 254164226 8178220 complement(4512575..4513321) 1 NC_012967.1 similar to b4306; putative methyltransferase 4513321 yjhP 8178220 yjhP Escherichia coli B str. REL606 putative methyltransferase YP_003047336.1 4512575 R 413997 CDS YP_003047337.1 254164227 8178221 complement(4513377..4513922) 1 NC_012967.1 similar to b4307; putative acetyltransferase 4513922 yjhQ 8178221 yjhQ Escherichia coli B str. REL606 putative acetyltransferase YP_003047337.1 4513377 R 413997 CDS YP_003047338.1 254164228 8178222 complement(4513934..4514191) 1 NC_012967.1 similar to b4566; hypothetical protein 4514191 8178222 ECB_04174 Escherichia coli B str. REL606 hypothetical protein YP_003047338.1 4513934 R 413997 CDS YP_003047339.1 254164229 8179374 complement(4516752..4517732) 1 NC_012967.1 similar to b4309; hypothetical protein 4517732 yjhS 8179374 yjhS Escherichia coli B str. REL606 hypothetical protein YP_003047339.1 4516752 R 413997 CDS YP_003047340.1 254164230 8179375 complement(4517797..4518903) 1 NC_012967.1 similar to b4310; N-acetylneuraminic acid mutarotase 4518903 yjhT 8179375 yjhT Escherichia coli B str. REL606 N-acetylneuraminic acid mutarotase YP_003047340.1 4517797 R 413997 CDS YP_003047341.1 254164231 8178224 complement(4518923..4519639) 1 NC_012967.1 similar to b4311; N-acetylnuraminic acid outer membrane channel protein 4519639 yjhA 8178224 yjhA Escherichia coli B str. REL606 N-acetylnuraminic acid outer membrane channel protein YP_003047341.1 4518923 R 413997 CDS YP_003047342.1 254164232 8178226 complement(4521586..4522089) 1 NC_012967.1 IS1 protein InsB 4522089 insB-27 8178226 insB-27 Escherichia coli B str. REL606 IS1 protein InsB YP_003047342.1 4521586 R 413997 CDS YP_003047343.1 254164233 8178842 complement(4522008..4522283) 1 NC_012967.1 IS1 protein InsA 4522283 insA-27 8178842 insA-27 Escherichia coli B str. REL606 IS1 protein InsA YP_003047343.1 4522008 R 413997 CDS YP_003047344.1 254164234 8178227 4522951..4523547 1 NC_012967.1 inversion of on/off regulator of fimA; tyrosine recombinase 4523547 fimE 8178227 fimE Escherichia coli B str. REL606 tyrosine recombinase YP_003047344.1 4522951 D 413997 CDS YP_003047345.1 254164235 8178228 4524029..4524577 1 NC_012967.1 similar to b4314; major type 1 subunit fimbrin (pilin) 4524577 fimA 8178228 fimA Escherichia coli B str. REL606 major type 1 subunit fimbrin (pilin) YP_003047345.1 4524029 D 413997 CDS YP_003047346.1 254164236 8178229 4524642..4525181 1 NC_012967.1 similar to b4315; type 1 pilus biosynthesis fimbrial protein 4525181 fimI 8178229 fimI Escherichia coli B str. REL606 type 1 pilus biosynthesis fimbrial protein YP_003047346.1 4524642 D 413997 CDS YP_003047347.1 254164237 8178230 4525218..4525943 1 NC_012967.1 similar to b4316; chaperone 4525943 fimC 8178230 fimC Escherichia coli B str. REL606 chaperone YP_003047347.1 4525218 D 413997 CDS YP_003047348.1 254164238 8178843 4526010..4528646 1 NC_012967.1 similar to b4317; outer membrane usher protein, type 1 fimbrial synthesis 4528646 fimD 8178843 fimD Escherichia coli B str. REL606 outer membrane usher protein, type 1 fimbrial synthesis YP_003047348.1 4526010 D 413997 CDS YP_003047349.1 254164239 8179376 4528656..4529186 1 NC_012967.1 similar to b4318; minor component of type 1 fimbriae 4529186 fimF 8179376 fimF Escherichia coli B str. REL606 minor component of type 1 fimbriae YP_003047349.1 4528656 D 413997 CDS YP_003047350.1 254164240 8178844 4529199..4529702 1 NC_012967.1 similar to b4319; minor component of type 1 fimbriae 4529702 fimG 8178844 fimG Escherichia coli B str. REL606 minor component of type 1 fimbriae YP_003047350.1 4529199 D 413997 CDS YP_003047351.1 254164241 8178231 4529722..4530624 1 NC_012967.1 similar to b4320; minor component of type 1 fimbriae 4530624 fimH 8178231 fimH Escherichia coli B str. REL606 minor component of type 1 fimbriae YP_003047351.1 4529722 D 413997 CDS YP_003047352.1 254164242 8178232 complement(4530867..4532210) 1 NC_012967.1 similar to b4321; fructuronate transporter 4532210 gntP 8178232 gntP Escherichia coli B str. REL606 fructuronate transporter YP_003047352.1 4530867 R 413997 CDS YP_003047353.1 254164243 8178845 4532550..4533734 1 NC_012967.1 catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate; mannonate dehydratase 4533734 uxuA 8178845 uxuA Escherichia coli B str. REL606 mannonate dehydratase YP_003047353.1 4532550 D 413997 CDS YP_003047354.1 254164244 8178233 4533815..4535275 1 NC_012967.1 similar to b4323; D-mannonate oxidoreductase 4535275 uxuB 8178233 uxuB Escherichia coli B str. REL606 D-mannonate oxidoreductase YP_003047354.1 4533815 D 413997 CDS YP_003047355.1 254164245 8178234 4535490..4536263 1 NC_012967.1 regulates the expression of uxuBA; DNA-binding transcriptional repressor UxuR 4536263 uxuR 8178234 uxuR Escherichia coli B str. REL606 DNA-binding transcriptional repressor UxuR YP_003047355.1 4535490 D 413997 CDS YP_003047356.1 254164246 8178235 complement(4536404..4537234) 1 NC_012967.1 similar to b4325; hypothetical protein 4537234 yjiC 8178235 yjiC Escherichia coli B str. REL606 hypothetical protein YP_003047356.1 4536404 R 413997 CDS YP_003047357.1 254164247 8178236 4537907..4538299 1 NC_012967.1 inhibitor of RssB activity in response to DNA damage; blocks degradation of stationary phase sigma factor RpoS; DNA replication/recombination/repair protein 4538299 iraD 8178236 iraD Escherichia coli B str. REL606 DNA replication/recombination/repair protein YP_003047357.1 4537907 D 413997 CDS YP_003047358.1 254164248 8178237 complement(4538292..4539203) 1 NC_012967.1 similar to b4327; putative DNA-binding transcriptional regulator 4539203 yjiE 8178237 yjiE Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003047358.1 4538292 R 413997 CDS YP_003047359.1 254164249 8179377 complement(4539268..4540440) 1 NC_012967.1 similar to b4328; isoaspartyl dipeptidase 4540440 iadA 8179377 iadA Escherichia coli B str. REL606 isoaspartyl dipeptidase YP_003047359.1 4539268 R 413997 CDS YP_003047360.1 254164250 8178238 complement(4540453..4540914) 1 NC_012967.1 similar to b4329; hypothetical protein 4540914 yjiG 8178238 yjiG Escherichia coli B str. REL606 hypothetical protein YP_003047360.1 4540453 R 413997 CDS YP_003047361.1 254164251 8178239 complement(4540911..4541594) 1 NC_012967.1 similar to b4330; inner membrane protein 4541594 yjiH 8178239 yjiH Escherichia coli B str. REL606 inner membrane protein YP_003047361.1 4540911 R 413997 CDS YP_003047362.1 254164252 8179378 4541844..4542398 1 NC_012967.1 in yeast cells this enzyme removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate; functions in tRNA splicing; the function and substrate of bacterial enzymes in organisms that do not perform splicing is unknown; RNA 2'-phosphotransferase-like protein 4542398 kptA 8179378 kptA Escherichia coli B str. REL606 RNA 2'-phosphotransferase-like protein YP_003047362.1 4541844 D 413997 CDS YP_003047363.1 254164253 8178240 complement(4542411..4543589) 1 NC_012967.1 similar to b4332; putative inner membrane protein 4543589 yjiJ 8178240 yjiJ Escherichia coli B str. REL606 putative inner membrane protein YP_003047363.1 4542411 R 413997 CDS YP_003047364.1 254164254 8178241 complement(4543657..4544625) 1 NC_012967.1 similar to b4333; hypothetical protein 4544625 yjiK 8178241 yjiK Escherichia coli B str. REL606 hypothetical protein YP_003047364.1 4543657 R 413997 CDS YP_003047365.1 254164255 8178846 complement(4544836..4545603) 1 NC_012967.1 similar to b4334; putative ATPase, activator of (R)-hydroxyglutaryl-CoA dehydratase 4545603 yjiL 8178846 yjiL Escherichia coli B str. REL606 putative ATPase, activator of (R)-hydroxyglutaryl-CoA dehydratase YP_003047365.1 4544836 R 413997 CDS YP_003047366.1 254164256 8178242 complement(4545613..4546764) 1 NC_012967.1 similar to b4335; putative 2-hydroxyglutaryl-CoA dehydratase 4546764 yjiM 8178242 yjiM Escherichia coli B str. REL606 putative 2-hydroxyglutaryl-CoA dehydratase YP_003047366.1 4545613 R 413997 CDS YP_003047367.1 254164257 8178243 complement(4546880..4548160) 1 NC_012967.1 similar to b4336; inner membrane protein 4548160 yjiN 8178243 yjiN Escherichia coli B str. REL606 inner membrane protein YP_003047367.1 4546880 R 413997 CDS YP_003047368.1 254164258 8178847 complement(4548201..4549433) 1 NC_012967.1 similar to b4337; multidrug efflux system protein 4549433 yjiO 8178847 yjiO Escherichia coli B str. REL606 multidrug efflux system protein YP_003047368.1 4548201 R 413997 CDS YP_003047369.1 254164259 8178244 4549912..4550679 1 NC_012967.1 similar to b4338-b4339; putative transposase 4550679 yjiPQ 8178244 yjiPQ Escherichia coli B str. REL606 putative transposase YP_003047369.1 4549912 D 413997 CDS YP_003047370.1 254164260 8178245 4550734..4551009 1 NC_012967.1 IS1 protein InsA 4551009 insA-28 8178245 insA-28 Escherichia coli B str. REL606 IS1 protein InsA YP_003047370.1 4550734 D 413997 CDS YP_003047371.1 254164261 8179379 4550928..4551431 1 NC_012967.1 IS1 protein InsB 4551431 insB-28 8179379 insB-28 Escherichia coli B str. REL606 IS1 protein InsB YP_003047371.1 4550928 D 413997 CDS YP_003047372.1 254164262 8178247 complement(4554857..4555903) 1 NC_012967.1 McrC protein together with McrB forms the McrBC restriction system; recognizes N4- and C5-methylcytosine (and 5-hydroxy-methylcytosines); appears to act against 5-methylcytosine preceded by a purine residue; MrcC modulates the specificty of McrB and has DNA cleavage activity; 5-methylcytosine-specific restriction enzyme subunit McrC 4555903 mcrC 8178247 mcrC Escherichia coli B str. REL606 5-methylcytosine-specific restriction enzyme subunit McrC YP_003047372.1 4554857 R 413997 CDS YP_003047373.1 254164263 8179380 complement(4555903..4557282) 1 NC_012967.1 McrB protein together with McrC forms the McrBC restriction system; recognizes N4- and C5-methylcytosine (and 5-hydroxy-methylcytosines); appears to act against 5-methylcytosine preceded by a purine residue; 5-methylcytosine-specific restriction enzyme subunit McrB 4557282 mcrB 8179380 mcrB Escherichia coli B str. REL606 5-methylcytosine-specific restriction enzyme subunit McrB YP_003047373.1 4555903 R 413997 CDS YP_003047374.1 254164264 8178248 complement(4557444..4557785) 1 NC_012967.1 involved in the degradation of RNA; may be involved in the recycling of RNA during the SOS response; endoribonuclease SymE 4557785 yjiW 8178248 yjiW Escherichia coli B str. REL606 endoribonuclease SymE YP_003047374.1 4557444 R 413997 CDS YP_003047375.1 254164265 8178249 complement(4558013..4559437) 1 NC_012967.1 similar to b4348; specificity determinant for hsdM and hsdR 4559437 hsdS 8178249 hsdS Escherichia coli B str. REL606 specificity determinant for hsdM and hsdR YP_003047375.1 4558013 R 413997 CDS YP_003047376.1 254164266 8178848 complement(4559434..4561023) 1 NC_012967.1 similar to b4349; DNA methylase M 4561023 hsdM 8178848 hsdM Escherichia coli B str. REL606 DNA methylase M YP_003047376.1 4559434 R 413997 CDS YP_003047377.1 254164267 8178250 complement(4561224..4564736) 1 NC_012967.1 restriction endonuclease; the EcoKI enzyme recognizes 5'-AACN(6)GTGC-3'; subunit R is required for both nuclease and ATPase activities; type I restriction enzyme EcoKI subunit R 4564736 hsdR 8178250 hsdR Escherichia coli B str. REL606 type I restriction enzyme EcoKI subunit R YP_003047377.1 4561224 R 413997 CDS YP_003047378.1 254164268 8178251 4564924..4565838 1 NC_012967.1 similar to b4351; methylated adenine and cytosine restriction protein 4565838 mrr 8178251 mrr Escherichia coli B str. REL606 methylated adenine and cytosine restriction protein YP_003047378.1 4564924 D 413997 CDS YP_003047379.1 254164269 8178849 complement(4565884..4566840) 1 NC_012967.1 similar to b4352; putative GTP-binding protein YjiA 4566840 yjiA 8178849 yjiA Escherichia coli B str. REL606 putative GTP-binding protein YjiA YP_003047379.1 4565884 R 413997 CDS YP_003047380.1 254164270 8178252 complement(4566851..4567054) 1 NC_012967.1 similar to b4353; hypothetical protein 4567054 yjiX 8178252 yjiX Escherichia coli B str. REL606 hypothetical protein YP_003047380.1 4566851 R 413997 CDS YP_003047381.1 254164271 8178253 complement(4567104..4569254) 1 NC_012967.1 similar to b4354; putative inner membrane protein 4569254 yjiY 8178253 yjiY Escherichia coli B str. REL606 putative inner membrane protein YP_003047381.1 4567104 R 413997 CDS YP_003047382.1 254164272 8178850 complement(4569647..4570159) 1 NC_012967.1 4-hydroxyphenylacetate 3-monooxygenase, reductase component 4570159 hpaC 8178850 hpaC Escherichia coli B str. REL606 4-hydroxyphenylacetate 3-monooxygenase, reductase component YP_003047382.1 4569647 R 413997 CDS YP_003047383.1 254164273 8178254 complement(4570177..4571739) 1 NC_012967.1 4-hydroxyphenylacetate 3-monooxygenase 4571739 hpaB 8178254 hpaB Escherichia coli B str. REL606 4-hydroxyphenylacetate 3-monooxygenase YP_003047383.1 4570177 R 413997 CDS YP_003047384.1 254164274 8178255 complement(4571990..4572880) 1 NC_012967.1 HpaA 4572880 hpaA 8178255 hpaA Escherichia coli B str. REL606 HpaA YP_003047384.1 4571990 R 413997 CDS YP_003047385.1 254164275 8178256 complement(4572890..4574266) 1 NC_012967.1 4-hydroxyphenylacetate permease 4574266 hpaX 8178256 hpaX Escherichia coli B str. REL606 4-hydroxyphenylacetate permease YP_003047385.1 4572890 R 413997 CDS YP_003047386.1 254164276 8178257 complement(4574390..4575178) 1 NC_012967.1 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase 4575178 hpaI 8178257 hpaI Escherichia coli B str. REL606 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase YP_003047386.1 4574390 R 413997 CDS YP_003047387.1 254164277 8178258 complement(4575189..4575992) 1 NC_012967.1 2-oxo-hept-3-ene-1,7-dioate hydratase 4575992 hpaH 8178258 hpaH Escherichia coli B str. REL606 2-oxo-hept-3-ene-1,7-dioate hydratase YP_003047387.1 4575189 R 413997 CDS YP_003047388.1 254164278 8178851 complement(4576060..4576440) 1 NC_012967.1 5-carboxymethyl-2-hydroxymuconate delta-isomerase 4576440 hpaF 8178851 hpaF Escherichia coli B str. REL606 5-carboxymethyl-2-hydroxymuconate delta-isomerase YP_003047388.1 4576060 R 413997 CDS YP_003047389.1 254164279 8178259 complement(4576450..4577301) 1 NC_012967.1 Homoprotocatechuate dyoxygenase 4577301 hpaD 8178259 hpaD Escherichia coli B str. REL606 Homoprotocatechuate dyoxygenase YP_003047389.1 4576450 R 413997 CDS YP_003047390.1 254164280 8178260 complement(4577303..4578769) 1 NC_012967.1 5-carboxy-2-hydroxymuconate semialdehyde dehydrogenase 4578769 hpaE 8178260 hpaE Escherichia coli B str. REL606 5-carboxy-2-hydroxymuconate semialdehyde dehydrogenase YP_003047390.1 4577303 R 413997 CDS YP_003047391.1 254164281 8178852 complement(4578766..4580055) 1 NC_012967.1 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase 4580055 hpaG 8178852 hpaG Escherichia coli B str. REL606 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase YP_003047391.1 4578766 R 413997 CDS YP_003047392.1 254164282 8178261 4580327..4580773 1 NC_012967.1 Homoprotocatechuate degradative operon repressor 4580773 hpaR 8178261 hpaR Escherichia coli B str. REL606 Homoprotocatechuate degradative operon repressor YP_003047392.1 4580327 D 413997 CDS YP_003047393.1 254164283 8178262 4580892..4582547 1 NC_012967.1 similar to b4355; methyl-accepting chemotaxis protein I, serine sensor receptor 4582547 tsr 8178262 tsr Escherichia coli B str. REL606 methyl-accepting chemotaxis protein I, serine sensor receptor YP_003047393.1 4580892 D 413997 CDS YP_003047394.1 254164284 8178263 complement(4582596..4583957) 1 NC_012967.1 similar to b4356; putative transporter 4583957 yjiZ 8178263 yjiZ Escherichia coli B str. REL606 putative transporter YP_003047394.1 4582596 R 413997 CDS YP_003047395.1 254164285 8178265 4585224..4586246 1 NC_012967.1 similar to b4358; putative oxidoreductase, Zn-dependent and NAD(P)-binding 4586246 yjjN 8178265 yjjN Escherichia coli B str. REL606 putative oxidoreductase, Zn-dependent and NAD(P)-binding YP_003047395.1 4585224 D 413997 CDS YP_003047396.1 254164286 8178266 complement(4586384..4588675) 1 NC_012967.1 catalyzes the transfer of phosphoglycerol to the glucan backbone; phosphoglycerol transferase I 4588675 mdoB 8178266 mdoB Escherichia coli B str. REL606 phosphoglycerol transferase I YP_003047396.1 4586384 R 413997 CDS YP_003047397.1 254164287 8178267 complement(4588929..4589423) 1 NC_012967.1 similar to b4360; hypothetical protein 4589423 yjjA 8178267 yjjA Escherichia coli B str. REL606 hypothetical protein YP_003047397.1 4588929 R 413997 CDS YP_003047398.1 254164288 8179381 complement(4589472..4590209) 1 NC_012967.1 acts to load the DnaB helicase onto the initiation site during DNA replication; DNA replication protein DnaC 4590209 dnaC 8179381 dnaC Escherichia coli B str. REL606 DNA replication protein DnaC YP_003047398.1 4589472 R 413997 CDS YP_003047399.1 254164289 8178268 complement(4590212..4590751) 1 NC_012967.1 This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'; primosomal protein DnaI 4590751 dnaT 8178268 dnaT Escherichia coli B str. REL606 primosomal protein DnaI YP_003047399.1 4590212 R 413997 CDS YP_003047400.1 254164290 8178269 complement(4590858..4591184) 1 NC_012967.1 similar to b4363; inner membrane protein 4591184 yjjB 8178269 yjjB Escherichia coli B str. REL606 inner membrane protein YP_003047400.1 4590858 R 413997 CDS YP_003047401.1 254164291 8178853 complement(4591322..4592092) 1 NC_012967.1 similar to b4364; putative inner membrane protein 4592092 yjjP 8178853 yjjP Escherichia coli B str. REL606 putative inner membrane protein YP_003047401.1 4591322 R 413997 CDS YP_003047402.1 254164292 8178270 4592711..4593436 1 NC_012967.1 similar to b4365; putative DNA-binding transcriptional regulator 4593436 yjjQ 8178270 yjjQ Escherichia coli B str. REL606 putative DNA-binding transcriptional regulator YP_003047402.1 4592711 D 413997 CDS YP_003047403.1 254164293 8178271 4593448..4594071 1 NC_012967.1 regulator for the transport and utilization of the aromatic beta-glucosides arbutin and silicin; DNA-binding transcriptional activator BglJ 4594071 bglJ 8178271 bglJ Escherichia coli B str. REL606 DNA-binding transcriptional activator BglJ YP_003047403.1 4593448 D 413997 CDS YP_003047404.1 254164294 8178854 complement(4594109..4594897) 1 NC_012967.1 similar to b4367; ferric iron reductase involved in ferric hydroximate transport 4594897 fhuF 8178854 fhuF Escherichia coli B str. REL606 ferric iron reductase involved in ferric hydroximate transport YP_003047404.1 4594109 R 413997 CDS YP_003047405.1 254164295 8178272 4595038..4595274 1 NC_012967.1 similar to b4567; hypothetical protein 4595274 yjjZ 8178272 yjjZ Escherichia coli B str. REL606 hypothetical protein YP_003047405.1 4595038 D 413997 CDS YP_003047406.1 254164296 8179383 complement(4595903..4596934) 1 NC_012967.1 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit; 16S ribosomal RNA m2G1207 methyltransferase 4596934 rsmC 8179383 rsmC Escherichia coli B str. REL606 16S ribosomal RNA m2G1207 methyltransferase YP_003047406.1 4595903 R 413997 CDS YP_003047407.1 254164297 8178275 4597037..4597450 1 NC_012967.1 with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit psi 4597450 holD 8178275 holD Escherichia coli B str. REL606 DNA polymerase III subunit psi YP_003047407.1 4597037 D 413997 CDS YP_003047408.1 254164298 8178276 4597419..4597865 1 NC_012967.1 alanine acetyltransferase that specifically acetylates ribosomal protein S18; ribosomal-protein-alanine N-acetyltransferase 4597865 rimI 8178276 rimI Escherichia coli B str. REL606 ribosomal-protein-alanine N-acetyltransferase YP_003047408.1 4597419 D 413997 CDS YP_003047409.1 254164299 8178855 4597880..4598557 1 NC_012967.1 manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily; nucleotidase 4598557 yjjG 8178855 yjjG Escherichia coli B str. REL606 nucleotidase YP_003047409.1 4597880 D 413997 CDS YP_003047410.1 254164300 8178277 4598648..4600237 1 NC_012967.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 4600237 prfC 8178277 prfC Escherichia coli B str. REL606 peptide chain release factor 3 YP_003047410.1 4598648 D 413997 CDS YP_003047411.1 254164301 8178278 4600630..4601235 1 NC_012967.1 similar to b4376; periplasmic protein 4601235 osmY 8178278 osmY Escherichia coli B str. REL606 periplasmic protein YP_003047411.1 4600630 D 413997 CDS YP_003047412.1 254164302 8178856 4601344..4601523 1 NC_012967.1 similar to b4568; hypothetical protein 4601523 ytjA 8178856 ytjA Escherichia coli B str. REL606 hypothetical protein YP_003047412.1 4601344 D 413997 CDS YP_003047413.1 254164303 8178279 4601645..4602718 1 NC_012967.1 similar to b4377; putative esterase 4602718 yjjU 8178279 yjjU Escherichia coli B str. REL606 putative esterase YP_003047413.1 4601645 D 413997 CDS YP_003047414.1 254164304 8178280 4602715..4603494 1 NC_012967.1 similar to b4378; putative deoxyribonuclease YjjV 4603494 yjjV 8178280 yjjV Escherichia coli B str. REL606 putative deoxyribonuclease YjjV YP_003047414.1 4602715 D 413997 CDS YP_003047415.1 254164305 8178281 complement(4603914..4604777) 1 NC_012967.1 similar to b4379; putative pyruvate formate lyase activating enzyme 4604777 yjjW 8178281 yjjW Escherichia coli B str. REL606 putative pyruvate formate lyase activating enzyme YP_003047415.1 4603914 R 413997 CDS YP_003047416.1 254164306 8178282 complement(4604749..4606299) 1 NC_012967.1 similar to b4380; hypothetical protein 4606299 yjjI 8178282 yjjI Escherichia coli B str. REL606 hypothetical protein YP_003047416.1 4604749 R 413997 CDS YP_003047417.1 254164307 8178283 4606557..4607336 1 NC_012967.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 4607336 deoC 8178283 deoC Escherichia coli B str. REL606 deoxyribose-phosphate aldolase YP_003047417.1 4606557 D 413997 CDS YP_003047418.1 254164308 8178284 4607463..4608785 1 NC_012967.1 Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate; thymidine phosphorylase 4608785 deoA 8178284 deoA Escherichia coli B str. REL606 thymidine phosphorylase YP_003047418.1 4607463 D 413997 CDS YP_003047419.1 254164309 8178285 4608837..4610060 1 NC_012967.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 4610060 deoB 8178285 deoB Escherichia coli B str. REL606 phosphopentomutase YP_003047419.1 4608837 D 413997 CDS YP_003047420.1 254164310 8179384 4610140..4610859 1 NC_012967.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 4610859 deoD 8179384 deoD Escherichia coli B str. REL606 purine nucleoside phosphorylase YP_003047420.1 4610140 D 413997 CDS YP_003047421.1 254164311 8178286 complement(4611020..4611283) 1 NC_012967.1 hypothetical protein 4611283 8178286 ECB_04261 Escherichia coli B str. REL606 hypothetical protein YP_003047421.1 4611020 R 413997 CDS YP_003047422.1 254164312 8178287 complement(4611315..4612331) 1 NC_012967.1 Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl on the lipoate-dependent enzymes. Creates an amide linkage that joins the free carboxyl group of lipoic acid to the epsilon-amino group of a specific lysine residue in lipoyl domain of apoproteins; lipoate-protein ligase A 4612331 lplA 8178287 lplA Escherichia coli B str. REL606 lipoate-protein ligase A YP_003047422.1 4611315 R 413997 CDS YP_003047423.1 254164313 8179385 complement(4612359..4613003) 1 NC_012967.1 similar to b4387; hypothetical protein 4613003 smp 8179385 smp Escherichia coli B str. REL606 hypothetical protein YP_003047423.1 4612359 R 413997 CDS YP_003047424.1 254164314 8178288 4613109..4614077 1 NC_012967.1 catalyzes the formation of serine from O-phosphoserine; phosphoserine phosphatase 4614077 serB 8178288 serB Escherichia coli B str. REL606 phosphoserine phosphatase YP_003047424.1 4613109 D 413997 CDS YP_003047425.1 254164315 8178289 4614126..4615508 1 NC_012967.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 4615508 sms 8178289 sms Escherichia coli B str. REL606 DNA repair protein RadA YP_003047425.1 4614126 D 413997 CDS YP_003047426.1 254164316 8179386 4615529..4616761 1 NC_012967.1 catalyzes the formation of NAD(+) from nicotinamide ribonucleotide; nicotinamide-nucleotide adenylyltransferase 4616761 nadR 8179386 nadR Escherichia coli B str. REL606 nicotinamide-nucleotide adenylyltransferase YP_003047426.1 4615529 D 413997 CDS YP_003047427.1 254164317 8178290 complement(4617068..4618735) 1 NC_012967.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; putative ABC transporter ATP-binding protein 4618735 yjjK 8178290 yjjK Escherichia coli B str. REL606 putative ABC transporter ATP-binding protein YP_003047427.1 4617068 R 413997 CDS YP_003047428.1 254164318 8178291 4618946..4620883 1 NC_012967.1 catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan; lytic murein transglycosylase 4620883 slt 8178291 slt Escherichia coli B str. REL606 lytic murein transglycosylase YP_003047428.1 4618946 D 413997 CDS YP_003047429.1 254164319 8178857 4620973..4621299 1 NC_012967.1 When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription; Trp operon repressor 4621299 trpR 8178857 trpR Escherichia coli B str. REL606 Trp operon repressor YP_003047429.1 4620973 D 413997 CDS YP_003047430.1 254164320 8178292 complement(4621384..4621905) 1 NC_012967.1 pyrophosphatase; has activity against dUTP and dITP; the crystal structure of the Vibrio protein showed similarity to Methanococcus janaschii Mj0226; in Vibrio cholerae this gene is part of the Mba operon that is involved in regulation and maintenance of biofilms; in Escherichia coli overexpression of this gene leads to resistance to an HMP analog; NTPase 4621905 yjjX 8178292 yjjX Escherichia coli B str. REL606 NTPase YP_003047430.1 4621384 R 413997 CDS YP_003047431.1 254164321 8178293 4621957..4622604 1 NC_012967.1 catalyzes reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate; phosphoglycerate mutase 4622604 gpmB 8178293 gpmB Escherichia coli B str. REL606 phosphoglycerate mutase YP_003047431.1 4621957 D 413997 CDS YP_003047432.1 254164322 8178858 complement(4622601..4623470) 1 NC_012967.1 similar to b4396; DNA-binding transcriptional activator 4623470 rob 8178858 rob Escherichia coli B str. REL606 DNA-binding transcriptional activator YP_003047432.1 4622601 R 413997 CDS YP_003047433.1 254164323 8178294 4623681..4624154 1 NC_012967.1 similar to b4397; hypothetical protein 4624154 creA 8178294 creA Escherichia coli B str. REL606 hypothetical protein YP_003047433.1 4623681 D 413997 CDS YP_003047434.1 254164324 8178295 4624167..4624856 1 NC_012967.1 response regulator in two-component regulatory system with CreC; CreB protein is phosphorylated by sensor protein phospho-CreC; involved in catabolic regulation; DNA-binding response regulator CreB 4624856 creB 8178295 creB Escherichia coli B str. REL606 DNA-binding response regulator CreB YP_003047434.1 4624167 D 413997 CDS YP_003047435.1 254164325 8178296 4624856..4626280 1 NC_012967.1 part of a two-component regulatory system with CreB or PhoB; involved in catabolic regulation; sensory histidine kinase CreC 4626280 creC 8178296 creC Escherichia coli B str. REL606 sensory histidine kinase CreC YP_003047435.1 4624856 D 413997 CDS YP_003047436.1 254164326 8178297 complement(4627750..4628466) 1 NC_012967.1 similar to b4401; two-component response regulator 4628466 arcA 8178297 arcA Escherichia coli B str. REL606 two-component response regulator YP_003047436.1 4627750 R 413997 CDS YP_003047437.1 254164327 8178298 4628562..4628702 1 NC_012967.1 similar to b4402; hypothetical protein 4628702 yjjY 8178298 yjjY Escherichia coli B str. REL606 hypothetical protein YP_003047437.1 4628562 D 413997 CDS YP_003047438.1 254164328 8178860 4629102..4629788 1 NC_012967.1 member of the SPOUT superfamily of methyltransferases; putative RNA methyltransferase 4629788 lasT 8178860 lasT Escherichia coli B str. REL606 putative RNA methyltransferase YP_003047438.1 4629102 D 413997 CDS