-- dump date 20140619_081904 -- class Genbank::misc_feature -- table misc_feature_note -- id note 536056000001 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 536056000002 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 536056000003 putative catalytic residues [active] 536056000004 putative nucleotide binding site [chemical binding]; other site 536056000005 putative aspartate binding site [chemical binding]; other site 536056000006 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 536056000007 dimer interface [polypeptide binding]; other site 536056000008 putative threonine allosteric regulatory site; other site 536056000009 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 536056000010 putative threonine allosteric regulatory site; other site 536056000011 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 536056000012 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 536056000013 homoserine kinase; Region: thrB; TIGR00191 536056000014 Protein of unknown function; Region: YhfT; pfam10797 536056000015 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 536056000016 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 536056000017 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 536056000018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056000019 catalytic residue [active] 536056000020 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 536056000021 hypothetical protein; Validated; Region: PRK02101 536056000022 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 536056000023 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 536056000024 transaldolase-like protein; Provisional; Region: PTZ00411 536056000025 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 536056000026 active site 536056000027 dimer interface [polypeptide binding]; other site 536056000028 catalytic residue [active] 536056000029 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 536056000030 MPT binding site; other site 536056000031 trimer interface [polypeptide binding]; other site 536056000032 hypothetical protein; Provisional; Region: PRK10659 536056000033 hypothetical protein; Provisional; Region: PRK10236 536056000034 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 536056000035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 536056000036 hypothetical protein; Provisional; Region: PRK10154 536056000037 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 536056000038 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 536056000039 nucleotide binding site [chemical binding]; other site 536056000040 NEF interaction site [polypeptide binding]; other site 536056000041 SBD interface [polypeptide binding]; other site 536056000042 chaperone protein DnaJ; Provisional; Region: PRK10767 536056000043 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 536056000044 HSP70 interaction site [polypeptide binding]; other site 536056000045 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 536056000046 substrate binding site [polypeptide binding]; other site 536056000047 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 536056000048 Zn binding sites [ion binding]; other site 536056000049 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 536056000050 dimer interface [polypeptide binding]; other site 536056000051 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 536056000052 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 536056000053 Hok/gef family; Region: HOK_GEF; pfam01848 536056000054 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 536056000055 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 536056000056 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056000057 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 536056000058 putative dimerization interface [polypeptide binding]; other site 536056000059 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 536056000060 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 536056000061 Protein of unknown function (DUF2575); Region: DUF2575; pfam10837 536056000062 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 536056000063 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 536056000064 active site 536056000065 Riboflavin kinase; Region: Flavokinase; smart00904 536056000066 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 536056000067 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 536056000068 HIGH motif; other site 536056000069 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 536056000070 active site 536056000071 KMSKS motif; other site 536056000072 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 536056000073 tRNA binding surface [nucleotide binding]; other site 536056000074 anticodon binding site; other site 536056000075 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 536056000076 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 536056000077 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 536056000078 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 536056000079 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 536056000080 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 536056000081 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 536056000082 active site 536056000083 tetramer interface [polypeptide binding]; other site 536056000084 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 536056000085 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 536056000086 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 536056000087 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 536056000088 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 536056000089 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 536056000090 catalytic site [active] 536056000091 subunit interface [polypeptide binding]; other site 536056000092 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 536056000093 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 536056000094 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 536056000095 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 536056000096 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 536056000097 ATP-grasp domain; Region: ATP-grasp_4; cl17255 536056000098 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 536056000099 IMP binding site; other site 536056000100 dimer interface [polypeptide binding]; other site 536056000101 interdomain contacts; other site 536056000102 partial ornithine binding site; other site 536056000103 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 536056000104 carnitine operon protein CaiE; Provisional; Region: PRK13627 536056000105 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 536056000106 putative trimer interface [polypeptide binding]; other site 536056000107 putative metal binding site [ion binding]; other site 536056000108 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 536056000109 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 536056000110 substrate binding site [chemical binding]; other site 536056000111 oxyanion hole (OAH) forming residues; other site 536056000112 trimer interface [polypeptide binding]; other site 536056000113 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 536056000114 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 536056000115 acyl-activating enzyme (AAE) consensus motif; other site 536056000116 putative AMP binding site [chemical binding]; other site 536056000117 putative active site [active] 536056000118 putative CoA binding site [chemical binding]; other site 536056000119 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 536056000120 CoA-transferase family III; Region: CoA_transf_3; pfam02515 536056000121 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 536056000122 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 536056000123 active site 536056000124 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 536056000125 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 536056000126 Ligand binding site [chemical binding]; other site 536056000127 Electron transfer flavoprotein domain; Region: ETF; pfam01012 536056000128 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 536056000129 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 536056000130 Ligand binding site [chemical binding]; other site 536056000131 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 536056000132 putative oxidoreductase FixC; Provisional; Region: PRK10157 536056000133 ferredoxin-like protein FixX; Provisional; Region: PRK15449 536056000134 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056000135 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 536056000136 putative substrate translocation pore; other site 536056000137 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 536056000138 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 536056000139 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 536056000140 TrkA-N domain; Region: TrkA_N; pfam02254 536056000141 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 536056000142 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 536056000143 folate binding site [chemical binding]; other site 536056000144 NADP+ binding site [chemical binding]; other site 536056000145 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 536056000146 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 536056000147 active site 536056000148 metal binding site [ion binding]; metal-binding site 536056000149 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 536056000150 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 536056000151 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 536056000152 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 536056000153 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 536056000154 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 536056000155 SurA N-terminal domain; Region: SurA_N; pfam09312 536056000156 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 536056000157 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 536056000158 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 536056000159 OstA-like protein; Region: OstA; pfam03968 536056000160 Organic solvent tolerance protein; Region: OstA_C; pfam04453 536056000161 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 536056000162 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 536056000163 putative metal binding site [ion binding]; other site 536056000164 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 536056000165 HSP70 interaction site [polypeptide binding]; other site 536056000166 potential frameshift: common BLAST hit: gi|254791195|ref|YP_003076032.1| non-LEE-encoded type III effector 536056000167 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 536056000168 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 536056000169 active site 536056000170 ATP-dependent helicase HepA; Validated; Region: PRK04914 536056000171 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 536056000172 ATP binding site [chemical binding]; other site 536056000173 putative Mg++ binding site [ion binding]; other site 536056000174 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 536056000175 nucleotide binding region [chemical binding]; other site 536056000176 ATP-binding site [chemical binding]; other site 536056000177 DNA polymerase II; Reviewed; Region: PRK05762 536056000178 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 536056000179 active site 536056000180 catalytic site [active] 536056000181 substrate binding site [chemical binding]; other site 536056000182 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 536056000183 active site 536056000184 metal-binding site 536056000185 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 536056000186 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 536056000187 intersubunit interface [polypeptide binding]; other site 536056000188 active site 536056000189 Zn2+ binding site [ion binding]; other site 536056000190 L-arabinose isomerase; Provisional; Region: PRK02929 536056000191 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 536056000192 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 536056000193 trimer interface [polypeptide binding]; other site 536056000194 putative substrate binding site [chemical binding]; other site 536056000195 putative metal binding site [ion binding]; other site 536056000196 ribulokinase; Provisional; Region: PRK04123 536056000197 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 536056000198 N- and C-terminal domain interface [polypeptide binding]; other site 536056000199 active site 536056000200 MgATP binding site [chemical binding]; other site 536056000201 catalytic site [active] 536056000202 metal binding site [ion binding]; metal-binding site 536056000203 carbohydrate binding site [chemical binding]; other site 536056000204 homodimer interface [polypeptide binding]; other site 536056000205 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 536056000206 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 536056000207 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536056000208 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536056000209 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 536056000210 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 536056000211 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 536056000212 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 536056000213 Walker A/P-loop; other site 536056000214 ATP binding site [chemical binding]; other site 536056000215 Q-loop/lid; other site 536056000216 ABC transporter signature motif; other site 536056000217 Walker B; other site 536056000218 D-loop; other site 536056000219 H-loop/switch region; other site 536056000220 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 536056000221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056000222 dimer interface [polypeptide binding]; other site 536056000223 conserved gate region; other site 536056000224 putative PBP binding loops; other site 536056000225 ABC-ATPase subunit interface; other site 536056000226 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056000227 dimer interface [polypeptide binding]; other site 536056000228 conserved gate region; other site 536056000229 putative PBP binding loops; other site 536056000230 ABC-ATPase subunit interface; other site 536056000231 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 536056000232 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 536056000233 'function: ABC-type uncharacterized transport system, periplasmic component / transport; Not classified; transcriptional DNA-binding transcriptional activator of sgrS sRNA, a stop codon appeared' 536056000234 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056000235 sugar efflux transporter; Region: 2A0120; TIGR00899 536056000236 putative substrate translocation pore; other site 536056000237 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 536056000238 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 536056000239 substrate binding site [chemical binding]; other site 536056000240 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 536056000241 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 536056000242 substrate binding site [chemical binding]; other site 536056000243 ligand binding site [chemical binding]; other site 536056000244 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 536056000245 tartrate dehydrogenase; Region: TTC; TIGR02089 536056000246 2-isopropylmalate synthase; Validated; Region: PRK00915 536056000247 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 536056000248 active site 536056000249 catalytic residues [active] 536056000250 metal binding site [ion binding]; metal-binding site 536056000251 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 536056000252 leu operon leader peptide; Provisional; Region: PRK09925 536056000253 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 536056000254 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056000255 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 536056000256 putative substrate binding pocket [chemical binding]; other site 536056000257 putative dimerization interface [polypeptide binding]; other site 536056000258 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 536056000259 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 536056000260 PYR/PP interface [polypeptide binding]; other site 536056000261 dimer interface [polypeptide binding]; other site 536056000262 TPP binding site [chemical binding]; other site 536056000263 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 536056000264 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 536056000265 TPP-binding site [chemical binding]; other site 536056000266 dimer interface [polypeptide binding]; other site 536056000267 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 536056000268 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 536056000269 putative valine binding site [chemical binding]; other site 536056000270 dimer interface [polypeptide binding]; other site 536056000271 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 536056000272 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 536056000273 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 536056000274 DNA binding site [nucleotide binding] 536056000275 domain linker motif; other site 536056000276 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 536056000277 dimerization interface [polypeptide binding]; other site 536056000278 ligand binding site [chemical binding]; other site 536056000279 mraZ protein; Region: TIGR00242 536056000280 MraZ protein; Region: MraZ; pfam02381 536056000281 MraZ protein; Region: MraZ; pfam02381 536056000282 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 536056000283 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 536056000284 cell division protein FtsL; Provisional; Region: PRK10772 536056000285 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 536056000286 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 536056000287 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 536056000288 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 536056000289 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 536056000290 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 536056000291 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 536056000292 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 536056000293 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 536056000294 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 536056000295 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 536056000296 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 536056000297 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 536056000298 Mg++ binding site [ion binding]; other site 536056000299 putative catalytic motif [active] 536056000300 putative substrate binding site [chemical binding]; other site 536056000301 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 536056000302 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 536056000303 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 536056000304 cell division protein FtsW; Provisional; Region: PRK10774 536056000305 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 536056000306 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 536056000307 active site 536056000308 homodimer interface [polypeptide binding]; other site 536056000309 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 536056000310 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 536056000311 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 536056000312 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 536056000313 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 536056000314 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 536056000315 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 536056000316 cell division protein FtsQ; Provisional; Region: PRK10775 536056000317 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 536056000318 Cell division protein FtsQ; Region: FtsQ; pfam03799 536056000319 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 536056000320 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 536056000321 Cell division protein FtsA; Region: FtsA; pfam14450 536056000322 cell division protein FtsZ; Validated; Region: PRK09330 536056000323 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 536056000324 nucleotide binding site [chemical binding]; other site 536056000325 SulA interaction site; other site 536056000326 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 536056000327 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 536056000328 SecA regulator SecM; Provisional; Region: PRK02943 536056000329 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 536056000330 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 536056000331 SEC-C motif; Region: SEC-C; pfam02810 536056000332 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 536056000333 active site 536056000334 8-oxo-dGMP binding site [chemical binding]; other site 536056000335 nudix motif; other site 536056000336 metal binding site [ion binding]; metal-binding site 536056000337 DNA gyrase inhibitor; Reviewed; Region: PRK00418 536056000338 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 536056000339 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 536056000340 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 536056000341 CoA-binding site [chemical binding]; other site 536056000342 ATP-binding [chemical binding]; other site 536056000343 'function: IMP dehydrogenase/GMP reductase; guanosine 5'-monophosphate oxidoreductase, a stop codon appeared' 536056000344 type IV pilin biogenesis protein; Provisional; Region: PRK10573 536056000345 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 536056000346 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 536056000347 hypothetical protein; Provisional; Region: PRK10436 536056000348 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 536056000349 Walker A motif; other site 536056000350 ATP binding site [chemical binding]; other site 536056000351 Walker B motif; other site 536056000352 putative major pilin subunit; Provisional; Region: PRK10574 536056000353 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 536056000354 Pilin (bacterial filament); Region: Pilin; pfam00114 536056000355 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 536056000356 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 536056000357 dimerization interface [polypeptide binding]; other site 536056000358 active site 536056000359 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 536056000360 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 536056000361 amidase catalytic site [active] 536056000362 Zn binding residues [ion binding]; other site 536056000363 substrate binding site [chemical binding]; other site 536056000364 regulatory protein AmpE; Provisional; Region: PRK10987 536056000365 aromatic amino acid transporter; Provisional; Region: PRK10238 536056000366 Transcriptional regulators [Transcription]; Region: FadR; COG2186 536056000367 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536056000368 DNA-binding site [nucleotide binding]; DNA binding site 536056000369 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 536056000370 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 536056000371 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 536056000372 dimer interface [polypeptide binding]; other site 536056000373 TPP-binding site [chemical binding]; other site 536056000374 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 536056000375 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 536056000376 E3 interaction surface; other site 536056000377 lipoyl attachment site [posttranslational modification]; other site 536056000378 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 536056000379 E3 interaction surface; other site 536056000380 lipoyl attachment site [posttranslational modification]; other site 536056000381 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 536056000382 E3 interaction surface; other site 536056000383 lipoyl attachment site [posttranslational modification]; other site 536056000384 e3 binding domain; Region: E3_binding; pfam02817 536056000385 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 536056000386 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 536056000387 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 536056000388 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 536056000389 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 536056000390 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 536056000391 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 536056000392 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 536056000393 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 536056000394 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 536056000395 substrate binding site [chemical binding]; other site 536056000396 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 536056000397 substrate binding site [chemical binding]; other site 536056000398 ligand binding site [chemical binding]; other site 536056000399 hypothetical protein; Provisional; Region: PRK05248 536056000400 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 536056000401 spermidine synthase; Provisional; Region: PRK00811 536056000402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536056000403 S-adenosylmethionine binding site [chemical binding]; other site 536056000404 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 536056000405 multicopper oxidase; Provisional; Region: PRK10965 536056000406 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 536056000407 Multicopper oxidase; Region: Cu-oxidase; pfam00394 536056000408 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 536056000409 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 536056000410 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 536056000411 Trp docking motif [polypeptide binding]; other site 536056000412 putative active site [active] 536056000413 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 536056000414 active site 536056000415 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 536056000416 active site clefts [active] 536056000417 zinc binding site [ion binding]; other site 536056000418 dimer interface [polypeptide binding]; other site 536056000419 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 536056000420 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 536056000421 Walker A/P-loop; other site 536056000422 ATP binding site [chemical binding]; other site 536056000423 Q-loop/lid; other site 536056000424 ABC transporter signature motif; other site 536056000425 Walker B; other site 536056000426 D-loop; other site 536056000427 H-loop/switch region; other site 536056000428 inner membrane transport permease; Provisional; Region: PRK15066 536056000429 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 536056000430 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 536056000431 active pocket/dimerization site; other site 536056000432 active site 536056000433 phosphorylation site [posttranslational modification] 536056000434 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 536056000435 putative active site [active] 536056000436 putative metal binding site [ion binding]; other site 536056000437 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 536056000438 tetramerization interface [polypeptide binding]; other site 536056000439 active site 536056000440 Uncharacterized conserved protein [Function unknown]; Region: COG5464 536056000441 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 536056000442 pantoate--beta-alanine ligase; Region: panC; TIGR00018 536056000443 Pantoate-beta-alanine ligase; Region: PanC; cd00560 536056000444 active site 536056000445 ATP-binding site [chemical binding]; other site 536056000446 pantoate-binding site; other site 536056000447 HXXH motif; other site 536056000448 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 536056000449 oligomerization interface [polypeptide binding]; other site 536056000450 active site 536056000451 metal binding site [ion binding]; metal-binding site 536056000452 putative fimbrial-like adhesin protein; Provisional; Region: PRK09723 536056000453 putative fimbrial protein StaF; Provisional; Region: PRK15262 536056000454 putative fimbrial protein StaE; Provisional; Region: PRK15263 536056000455 Fimbrial protein; Region: Fimbrial; cl01416 536056000456 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 536056000457 PapC N-terminal domain; Region: PapC_N; pfam13954 536056000458 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 536056000459 PapC C-terminal domain; Region: PapC_C; pfam13953 536056000460 putative chaperone protein EcpD; Provisional; Region: PRK09926 536056000461 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 536056000462 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 536056000463 Fimbrial protein; Region: Fimbrial; cl01416 536056000464 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 536056000465 catalytic center binding site [active] 536056000466 ATP binding site [chemical binding]; other site 536056000467 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 536056000468 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 536056000469 active site 536056000470 NTP binding site [chemical binding]; other site 536056000471 metal binding triad [ion binding]; metal-binding site 536056000472 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 536056000473 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 536056000474 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 536056000475 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 536056000476 active site 536056000477 nucleotide binding site [chemical binding]; other site 536056000478 HIGH motif; other site 536056000479 KMSKS motif; other site 536056000480 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 536056000481 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 536056000482 2'-5' RNA ligase; Provisional; Region: PRK15124 536056000483 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 536056000484 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 536056000485 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 536056000486 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 536056000487 ATP binding site [chemical binding]; other site 536056000488 putative Mg++ binding site [ion binding]; other site 536056000489 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 536056000490 nucleotide binding region [chemical binding]; other site 536056000491 ATP-binding site [chemical binding]; other site 536056000492 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 536056000493 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 536056000494 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 536056000495 Transglycosylase; Region: Transgly; pfam00912 536056000496 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 536056000497 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 536056000498 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 536056000499 N-terminal plug; other site 536056000500 ligand-binding site [chemical binding]; other site 536056000501 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 536056000502 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 536056000503 Walker A/P-loop; other site 536056000504 ATP binding site [chemical binding]; other site 536056000505 Q-loop/lid; other site 536056000506 ABC transporter signature motif; other site 536056000507 Walker B; other site 536056000508 D-loop; other site 536056000509 H-loop/switch region; other site 536056000510 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 536056000511 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 536056000512 siderophore binding site; other site 536056000513 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 536056000514 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 536056000515 ABC-ATPase subunit interface; other site 536056000516 dimer interface [polypeptide binding]; other site 536056000517 putative PBP binding regions; other site 536056000518 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 536056000519 ABC-ATPase subunit interface; other site 536056000520 dimer interface [polypeptide binding]; other site 536056000521 putative PBP binding regions; other site 536056000522 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 536056000523 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 536056000524 inhibitor-cofactor binding pocket; inhibition site 536056000525 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056000526 catalytic residue [active] 536056000527 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 536056000528 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 536056000529 Cl- selectivity filter; other site 536056000530 Cl- binding residues [ion binding]; other site 536056000531 pore gating glutamate residue; other site 536056000532 dimer interface [polypeptide binding]; other site 536056000533 H+/Cl- coupling transport residue; other site 536056000534 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 536056000535 hypothetical protein; Provisional; Region: PRK10578 536056000536 UPF0126 domain; Region: UPF0126; pfam03458 536056000537 UPF0126 domain; Region: UPF0126; pfam03458 536056000538 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 536056000539 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 536056000540 cobalamin binding residues [chemical binding]; other site 536056000541 putative BtuC binding residues; other site 536056000542 dimer interface [polypeptide binding]; other site 536056000543 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 536056000544 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 536056000545 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 536056000546 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 536056000547 Zn2+ binding site [ion binding]; other site 536056000548 Mg2+ binding site [ion binding]; other site 536056000549 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 536056000550 serine endoprotease; Provisional; Region: PRK10942 536056000551 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 536056000552 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 536056000553 protein binding site [polypeptide binding]; other site 536056000554 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 536056000555 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 536056000556 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 536056000557 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 536056000558 hypothetical protein; Provisional; Region: PRK13677 536056000559 phosphodiesterase YaeI; Provisional; Region: PRK11340 536056000560 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 536056000561 putative active site [active] 536056000562 putative metal binding site [ion binding]; other site 536056000563 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 536056000564 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 536056000565 trimer interface [polypeptide binding]; other site 536056000566 active site 536056000567 substrate binding site [chemical binding]; other site 536056000568 CoA binding site [chemical binding]; other site 536056000569 PII uridylyl-transferase; Provisional; Region: PRK05007 536056000570 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 536056000571 metal binding triad; other site 536056000572 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 536056000573 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 536056000574 Zn2+ binding site [ion binding]; other site 536056000575 Mg2+ binding site [ion binding]; other site 536056000576 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 536056000577 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 536056000578 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 536056000579 active site 536056000580 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 536056000581 rRNA interaction site [nucleotide binding]; other site 536056000582 S8 interaction site; other site 536056000583 putative laminin-1 binding site; other site 536056000584 elongation factor Ts; Provisional; Region: tsf; PRK09377 536056000585 UBA/TS-N domain; Region: UBA; pfam00627 536056000586 Elongation factor TS; Region: EF_TS; pfam00889 536056000587 Elongation factor TS; Region: EF_TS; pfam00889 536056000588 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 536056000589 putative nucleotide binding site [chemical binding]; other site 536056000590 uridine monophosphate binding site [chemical binding]; other site 536056000591 homohexameric interface [polypeptide binding]; other site 536056000592 ribosome recycling factor; Reviewed; Region: frr; PRK00083 536056000593 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 536056000594 hinge region; other site 536056000595 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 536056000596 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 536056000597 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 536056000598 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 536056000599 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 536056000600 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 536056000601 catalytic residue [active] 536056000602 putative FPP diphosphate binding site; other site 536056000603 putative FPP binding hydrophobic cleft; other site 536056000604 dimer interface [polypeptide binding]; other site 536056000605 putative IPP diphosphate binding site; other site 536056000606 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 536056000607 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 536056000608 zinc metallopeptidase RseP; Provisional; Region: PRK10779 536056000609 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 536056000610 active site 536056000611 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 536056000612 protein binding site [polypeptide binding]; other site 536056000613 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 536056000614 putative substrate binding region [chemical binding]; other site 536056000615 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 536056000616 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 536056000617 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 536056000618 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 536056000619 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 536056000620 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 536056000621 Surface antigen; Region: Bac_surface_Ag; pfam01103 536056000622 periplasmic chaperone; Provisional; Region: PRK10780 536056000623 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 536056000624 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 536056000625 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 536056000626 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 536056000627 trimer interface [polypeptide binding]; other site 536056000628 active site 536056000629 UDP-GlcNAc binding site [chemical binding]; other site 536056000630 lipid binding site [chemical binding]; lipid-binding site 536056000631 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 536056000632 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 536056000633 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 536056000634 active site 536056000635 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 536056000636 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 536056000637 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 536056000638 RNA/DNA hybrid binding site [nucleotide binding]; other site 536056000639 active site 536056000640 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 536056000641 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 536056000642 putative active site [active] 536056000643 putative PHP Thumb interface [polypeptide binding]; other site 536056000644 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 536056000645 generic binding surface II; other site 536056000646 generic binding surface I; other site 536056000647 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 536056000648 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 536056000649 lysine decarboxylase LdcC; Provisional; Region: PRK15399 536056000650 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 536056000651 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 536056000652 homodimer interface [polypeptide binding]; other site 536056000653 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056000654 catalytic residue [active] 536056000655 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 536056000656 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 536056000657 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 536056000658 putative metal binding site [ion binding]; other site 536056000659 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 536056000660 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 536056000661 Ligand Binding Site [chemical binding]; other site 536056000662 TilS substrate binding domain; Region: TilS; pfam09179 536056000663 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 536056000664 Rho-binding antiterminator; Provisional; Region: PRK11625 536056000665 hypothetical protein; Provisional; Region: PRK04964 536056000666 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 536056000667 hypothetical protein; Provisional; Region: PRK09256 536056000668 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 536056000669 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 536056000670 NlpE N-terminal domain; Region: NlpE; pfam04170 536056000671 hypothetical protein; Provisional; Region: PRK11479 536056000672 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 536056000673 prolyl-tRNA synthetase; Provisional; Region: PRK09194 536056000674 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 536056000675 dimer interface [polypeptide binding]; other site 536056000676 motif 1; other site 536056000677 active site 536056000678 motif 2; other site 536056000679 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 536056000680 putative deacylase active site [active] 536056000681 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 536056000682 active site 536056000683 motif 3; other site 536056000684 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 536056000685 anticodon binding site; other site 536056000686 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 536056000687 homodimer interaction site [polypeptide binding]; other site 536056000688 cofactor binding site; other site 536056000689 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 536056000690 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 536056000691 lipoprotein, YaeC family; Region: TIGR00363 536056000692 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056000693 dimer interface [polypeptide binding]; other site 536056000694 conserved gate region; other site 536056000695 ABC-ATPase subunit interface; other site 536056000696 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 536056000697 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 536056000698 Walker A/P-loop; other site 536056000699 ATP binding site [chemical binding]; other site 536056000700 Q-loop/lid; other site 536056000701 ABC transporter signature motif; other site 536056000702 Walker B; other site 536056000703 D-loop; other site 536056000704 H-loop/switch region; other site 536056000705 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 536056000706 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 536056000707 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536056000708 active site 536056000709 motif I; other site 536056000710 motif II; other site 536056000711 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 536056000712 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 536056000713 active site 536056000714 catalytic tetrad [active] 536056000715 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536056000716 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056000717 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 536056000718 putative effector binding pocket; other site 536056000719 dimerization interface [polypeptide binding]; other site 536056000720 hypothetical protein; Provisional; Region: PRK05421 536056000721 putative catalytic site [active] 536056000722 putative metal binding site [ion binding]; other site 536056000723 putative phosphate binding site [ion binding]; other site 536056000724 putative catalytic site [active] 536056000725 putative phosphate binding site [ion binding]; other site 536056000726 putative metal binding site [ion binding]; other site 536056000727 Methyltransferase domain; Region: Methyltransf_31; pfam13847 536056000728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536056000729 S-adenosylmethionine binding site [chemical binding]; other site 536056000730 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 536056000731 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 536056000732 N-acetyl-D-glucosamine binding site [chemical binding]; other site 536056000733 catalytic residue [active] 536056000734 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 536056000735 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 536056000736 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 536056000737 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536056000738 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 536056000739 RNA/DNA hybrid binding site [nucleotide binding]; other site 536056000740 active site 536056000741 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 536056000742 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 536056000743 active site 536056000744 catalytic site [active] 536056000745 substrate binding site [chemical binding]; other site 536056000746 Transposase [DNA replication, recombination, and repair]; Region: COG5433 536056000747 C-N hydrolase family amidase; Provisional; Region: PRK10438 536056000748 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 536056000749 putative active site [active] 536056000750 catalytic triad [active] 536056000751 dimer interface [polypeptide binding]; other site 536056000752 multimer interface [polypeptide binding]; other site 536056000753 C-lysozyme inhibitor; Provisional; Region: PRK09993 536056000754 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 536056000755 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 536056000756 active site 536056000757 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 536056000758 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 536056000759 dimer interface [polypeptide binding]; other site 536056000760 active site 536056000761 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 536056000762 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 536056000763 putative active site [active] 536056000764 putative dimer interface [polypeptide binding]; other site 536056000765 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 536056000766 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 536056000767 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 536056000768 RelB antitoxin; Region: RelB; pfam04221 536056000769 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 536056000770 NlpC/P60 family; Region: NLPC_P60; pfam00877 536056000771 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 536056000772 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 536056000773 FHIPEP family; Region: FHIPEP; pfam00771 536056000774 hypothetical protein; Validated; Region: PRK06778 536056000775 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 536056000776 ligand binding site [chemical binding]; other site 536056000777 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 536056000778 active site 536056000779 DNA polymerase IV; Validated; Region: PRK02406 536056000780 DNA binding site [nucleotide binding] 536056000781 putative antitoxin of the YafO-YafN toxin-antitoxin system; Provisional; Region: PRK09778 536056000782 putative toxin YafO; Provisional; Region: PRK09885 536056000783 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 536056000784 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536056000785 Coenzyme A binding pocket [chemical binding]; other site 536056000786 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 536056000787 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 536056000788 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 536056000789 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 536056000790 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 536056000791 metal binding site [ion binding]; metal-binding site 536056000792 dimer interface [polypeptide binding]; other site 536056000793 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 536056000794 active site 536056000795 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 536056000796 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 536056000797 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 536056000798 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 536056000799 trimer interface [polypeptide binding]; other site 536056000800 eyelet of channel; other site 536056000801 gamma-glutamyl kinase; Provisional; Region: PRK05429 536056000802 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 536056000803 nucleotide binding site [chemical binding]; other site 536056000804 homotetrameric interface [polypeptide binding]; other site 536056000805 putative phosphate binding site [ion binding]; other site 536056000806 putative allosteric binding site; other site 536056000807 PUA domain; Region: PUA; pfam01472 536056000808 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 536056000809 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 536056000810 putative catalytic cysteine [active] 536056000811 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 536056000812 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 536056000813 Protein of unknown function (DUF987); Region: DUF987; pfam06174 536056000814 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 536056000815 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 536056000816 MPN+ (JAMM) motif; other site 536056000817 Zinc-binding site [ion binding]; other site 536056000818 Antirestriction protein; Region: Antirestrict; pfam03230 536056000819 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 536056000820 Predicted transcriptional regulator [Transcription]; Region: COG2378 536056000821 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 536056000822 Domain of unknown function (DUF932); Region: DUF932; pfam06067 536056000823 Predicted GTPase [General function prediction only]; Region: COG3596 536056000824 YfjP GTPase; Region: YfjP; cd11383 536056000825 G1 box; other site 536056000826 GTP/Mg2+ binding site [chemical binding]; other site 536056000827 Switch I region; other site 536056000828 G2 box; other site 536056000829 Switch II region; other site 536056000830 G3 box; other site 536056000831 G4 box; other site 536056000832 G5 box; other site 536056000833 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 536056000834 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056000835 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 536056000836 dimerization interface [polypeptide binding]; other site 536056000837 substrate binding pocket [chemical binding]; other site 536056000838 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 536056000839 Transposase; Region: HTH_Tnp_1; pfam01527 536056000840 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 536056000841 Helix-turn-helix domain; Region: HTH_38; pfam13936 536056000842 Integrase core domain; Region: rve; pfam00665 536056000843 HTH-like domain; Region: HTH_21; pfam13276 536056000844 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 536056000845 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 536056000846 putative active site [active] 536056000847 putative NTP binding site [chemical binding]; other site 536056000848 putative nucleic acid binding site [nucleotide binding]; other site 536056000849 Transposase domain (DUF772); Region: DUF772; pfam05598 536056000850 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 536056000851 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 536056000852 S-methylmethionine transporter; Provisional; Region: PRK11387 536056000853 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 536056000854 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 536056000855 ferric transporter ATP-binding subunit; Provisional; Region: fbpC; PRK11432 536056000856 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 536056000857 Walker A/P-loop; other site 536056000858 ATP binding site [chemical binding]; other site 536056000859 Q-loop/lid; other site 536056000860 ABC transporter signature motif; other site 536056000861 Walker B; other site 536056000862 D-loop; other site 536056000863 H-loop/switch region; other site 536056000864 TOBE domain; Region: TOBE_2; pfam08402 536056000865 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 536056000866 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056000867 ABC-ATPase subunit interface; other site 536056000868 putative PBP binding loops; other site 536056000869 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 536056000870 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 536056000871 Transposase; Region: HTH_Tnp_1; pfam01527 536056000872 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 536056000873 Helix-turn-helix domain; Region: HTH_28; pfam13518 536056000874 Homeodomain-like domain; Region: HTH_32; pfam13565 536056000875 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 536056000876 Integrase core domain; Region: rve; pfam00665 536056000877 Integrase core domain; Region: rve_3; pfam13683 536056000878 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 536056000879 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 536056000880 inhibitor site; inhibition site 536056000881 active site 536056000882 dimer interface [polypeptide binding]; other site 536056000883 catalytic residue [active] 536056000884 putative dehydratase; Provisional; Region: PRK08211 536056000885 Dehydratase family; Region: ILVD_EDD; cl00340 536056000886 putative symporter YagG; Provisional; Region: PRK09669 536056000887 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 536056000888 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 536056000889 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 536056000890 inhibitor binding site; inhibition site 536056000891 active site 536056000892 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 536056000893 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 536056000894 Transcriptional regulator [Transcription]; Region: IclR; COG1414 536056000895 Bacterial transcriptional regulator; Region: IclR; pfam01614 536056000896 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 536056000897 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 536056000898 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 536056000899 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 536056000900 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 536056000901 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 536056000902 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 536056000903 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 536056000904 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 536056000905 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 536056000906 Transposase domain (DUF772); Region: DUF772; pfam05598 536056000907 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 536056000908 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 536056000909 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 536056000910 active site 536056000911 DNA binding site [nucleotide binding] 536056000912 Int/Topo IB signature motif; other site 536056000913 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536056000914 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 536056000915 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 536056000916 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 536056000917 XdhC Rossmann domain; Region: XdhC_C; pfam13478 536056000918 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 536056000919 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 536056000920 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 536056000921 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 536056000922 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 536056000923 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 536056000924 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2; pfam00111 536056000925 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 536056000926 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 536056000927 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 536056000928 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 536056000929 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 536056000930 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 536056000931 putative fimbrial protein TcfA; Provisional; Region: PRK15308 536056000932 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 536056000933 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536056000934 DNA binding residues [nucleotide binding] 536056000935 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 536056000936 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 536056000937 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 536056000938 Transposase; Region: HTH_Tnp_1; cl17663 536056000939 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 536056000940 Transposase; Region: HTH_Tnp_1; cl17663 536056000941 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 536056000942 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 536056000943 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536056000944 Predicted membrane protein [Function unknown]; Region: COG3059 536056000945 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 536056000946 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 536056000947 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 536056000948 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 536056000949 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 536056000950 Cupin; Region: Cupin_6; pfam12852 536056000951 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 536056000952 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536056000953 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 536056000954 Cysteine-rich domain; Region: CCG; pfam02754 536056000955 Cysteine-rich domain; Region: CCG; pfam02754 536056000956 iron-sulfur cluster-binding protein; Region: TIGR00273 536056000957 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 536056000958 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 536056000959 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 536056000960 Uncharacterized conserved protein [Function unknown]; Region: COG1556 536056000961 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 536056000962 choline dehydrogenase; Validated; Region: PRK02106 536056000963 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 536056000964 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 536056000965 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 536056000966 tetrameric interface [polypeptide binding]; other site 536056000967 NAD binding site [chemical binding]; other site 536056000968 catalytic residues [active] 536056000969 transcriptional regulator BetI; Validated; Region: PRK00767 536056000970 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536056000971 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 536056000972 choline transport protein BetT; Provisional; Region: PRK09928 536056000973 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536056000974 DNA binding residues [nucleotide binding] 536056000975 dimerization interface [polypeptide binding]; other site 536056000976 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 536056000977 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 536056000978 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056000979 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 536056000980 dimerization interface [polypeptide binding]; other site 536056000981 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 536056000982 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 536056000983 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 536056000984 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 536056000985 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 536056000986 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 536056000987 CoA binding domain; Region: CoA_binding; pfam02629 536056000988 CoA-ligase; Region: Ligase_CoA; pfam00549 536056000989 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 536056000990 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 536056000991 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 536056000992 putative substrate binding site [chemical binding]; other site 536056000993 nucleotide binding site [chemical binding]; other site 536056000994 nucleotide binding site [chemical binding]; other site 536056000995 homodimer interface [polypeptide binding]; other site 536056000996 putative deaminase; Validated; Region: PRK06846 536056000997 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 536056000998 active site 536056000999 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 536056001000 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 536056001001 putative NAD(P) binding site [chemical binding]; other site 536056001002 putative substrate binding site [chemical binding]; other site 536056001003 catalytic Zn binding site [ion binding]; other site 536056001004 structural Zn binding site [ion binding]; other site 536056001005 dimer interface [polypeptide binding]; other site 536056001006 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 536056001007 hypothetical protein; Provisional; Region: PRK09929 536056001008 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 536056001009 Propionate catabolism activator; Region: PrpR_N; pfam06506 536056001010 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536056001011 Walker A motif; other site 536056001012 ATP binding site [chemical binding]; other site 536056001013 Walker B motif; other site 536056001014 arginine finger; other site 536056001015 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 536056001016 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 536056001017 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 536056001018 tetramer interface [polypeptide binding]; other site 536056001019 active site 536056001020 Mg2+/Mn2+ binding site [ion binding]; other site 536056001021 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 536056001022 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 536056001023 dimer interface [polypeptide binding]; other site 536056001024 active site 536056001025 citrylCoA binding site [chemical binding]; other site 536056001026 oxalacetate/citrate binding site [chemical binding]; other site 536056001027 coenzyme A binding site [chemical binding]; other site 536056001028 catalytic triad [active] 536056001029 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 536056001030 2-methylcitrate dehydratase; Region: prpD; TIGR02330 536056001031 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 536056001032 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 536056001033 acyl-activating enzyme (AAE) consensus motif; other site 536056001034 putative AMP binding site [chemical binding]; other site 536056001035 putative active site [active] 536056001036 putative CoA binding site [chemical binding]; other site 536056001037 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 536056001038 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 536056001039 Na binding site [ion binding]; other site 536056001040 putative substrate binding site [chemical binding]; other site 536056001041 cytosine deaminase; Provisional; Region: PRK09230 536056001042 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 536056001043 active site 536056001044 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 536056001045 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056001046 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 536056001047 dimerization interface [polypeptide binding]; other site 536056001048 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 536056001049 active site clefts [active] 536056001050 zinc binding site [ion binding]; other site 536056001051 dimer interface [polypeptide binding]; other site 536056001052 Cyanate lyase [Inorganic ion transport and metabolism]; Region: CynS; COG1513 536056001053 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 536056001054 oligomer interface [polypeptide binding]; other site 536056001055 active site 536056001056 putative cyanate transporter; Provisional; Region: cynX; PRK09705 536056001057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056001058 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 536056001059 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 536056001060 active site 536056001061 substrate binding site [chemical binding]; other site 536056001062 trimer interface [polypeptide binding]; other site 536056001063 CoA binding site [chemical binding]; other site 536056001064 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 536056001065 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056001066 putative substrate translocation pore; other site 536056001067 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 536056001068 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 536056001069 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 536056001070 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 536056001071 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 536056001072 lac repressor; Reviewed; Region: lacI; PRK09526 536056001073 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 536056001074 DNA binding site [nucleotide binding] 536056001075 domain linker motif; other site 536056001076 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 536056001077 ligand binding site [chemical binding]; other site 536056001078 dimerization interface (open form) [polypeptide binding]; other site 536056001079 dimerization interface (closed form) [polypeptide binding]; other site 536056001080 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 536056001081 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 536056001082 Bacterial transcriptional regulator; Region: IclR; pfam01614 536056001083 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 536056001084 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 536056001085 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 536056001086 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 536056001087 putative active site [active] 536056001088 Fe(II) binding site [ion binding]; other site 536056001089 putative dimer interface [polypeptide binding]; other site 536056001090 putative tetramer interface [polypeptide binding]; other site 536056001091 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 536056001092 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 536056001093 2-keto-4-pentenoate hydratase; Provisional; Region: mhpD; PRK11342 536056001094 acetaldehyde dehydrogenase; Validated; Region: PRK08300 536056001095 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 536056001096 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 536056001097 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 536056001098 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 536056001099 active site 536056001100 catalytic residues [active] 536056001101 metal binding site [ion binding]; metal-binding site 536056001102 DmpG-like communication domain; Region: DmpG_comm; pfam07836 536056001103 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 536056001104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056001105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056001106 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 536056001107 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 536056001108 S-formylglutathione hydrolase; Region: PLN02442 536056001109 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 536056001110 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 536056001111 substrate binding site [chemical binding]; other site 536056001112 catalytic Zn binding site [ion binding]; other site 536056001113 NAD binding site [chemical binding]; other site 536056001114 structural Zn binding site [ion binding]; other site 536056001115 dimer interface [polypeptide binding]; other site 536056001116 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 536056001117 putative metal binding site [ion binding]; other site 536056001118 putative homodimer interface [polypeptide binding]; other site 536056001119 putative homotetramer interface [polypeptide binding]; other site 536056001120 putative homodimer-homodimer interface [polypeptide binding]; other site 536056001121 putative allosteric switch controlling residues; other site 536056001122 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 536056001123 putative trimer interface [polypeptide binding]; other site 536056001124 putative CoA binding site [chemical binding]; other site 536056001125 IS2 repressor TnpA; Reviewed; Region: PRK09413 536056001126 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 536056001127 IS2 transposase TnpB; Reviewed; Region: PRK09409 536056001128 HTH-like domain; Region: HTH_21; pfam13276 536056001129 Integrase core domain; Region: rve; pfam00665 536056001130 Integrase core domain; Region: rve_3; pfam13683 536056001131 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 536056001132 putative trimer interface [polypeptide binding]; other site 536056001133 putative CoA binding site [chemical binding]; other site 536056001134 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 536056001135 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 536056001136 DXD motif; other site 536056001137 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 536056001138 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 536056001139 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536056001140 substrate binding pocket [chemical binding]; other site 536056001141 membrane-bound complex binding site; other site 536056001142 hinge residues; other site 536056001143 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 536056001144 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 536056001145 Walker A/P-loop; other site 536056001146 ATP binding site [chemical binding]; other site 536056001147 Q-loop/lid; other site 536056001148 ABC transporter signature motif; other site 536056001149 Walker B; other site 536056001150 D-loop; other site 536056001151 H-loop/switch region; other site 536056001152 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 536056001153 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056001154 dimer interface [polypeptide binding]; other site 536056001155 conserved gate region; other site 536056001156 putative PBP binding loops; other site 536056001157 ABC-ATPase subunit interface; other site 536056001158 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 536056001159 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 536056001160 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 536056001161 dimer interface [polypeptide binding]; other site 536056001162 active site 536056001163 Schiff base residues; other site 536056001164 putative transposase OrfB; Reviewed; Region: PHA02517 536056001165 HTH-like domain; Region: HTH_21; pfam13276 536056001166 Integrase core domain; Region: rve; pfam00665 536056001167 Integrase core domain; Region: rve_2; pfam13333 536056001168 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 536056001169 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 536056001170 Autotransporter beta-domain; Region: Autotransporter; pfam03797 536056001171 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 536056001172 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 536056001173 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 536056001174 microcin B17 transporter; Reviewed; Region: PRK11098 536056001175 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 536056001176 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 536056001177 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 536056001178 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 536056001179 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 536056001180 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 536056001181 anti-RssB factor; Provisional; Region: PRK10244 536056001182 alkaline phosphatase; Provisional; Region: PRK10518 536056001183 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 536056001184 dimer interface [polypeptide binding]; other site 536056001185 active site 536056001186 hypothetical protein; Provisional; Region: PRK11505 536056001187 psiF repeat; Region: PsiF_repeat; pfam07769 536056001188 psiF repeat; Region: PsiF_repeat; pfam07769 536056001189 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 536056001190 MASE2 domain; Region: MASE2; pfam05230 536056001191 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 536056001192 metal binding site [ion binding]; metal-binding site 536056001193 active site 536056001194 I-site; other site 536056001195 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 536056001196 pyrroline-5-carboxylate reductase; Region: PLN02688 536056001197 hypothetical protein; Validated; Region: PRK00124 536056001198 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 536056001199 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 536056001200 ADP binding site [chemical binding]; other site 536056001201 magnesium binding site [ion binding]; other site 536056001202 putative shikimate binding site; other site 536056001203 hypothetical protein; Provisional; Region: PRK10380 536056001204 hypothetical protein; Provisional; Region: PRK10481 536056001205 hypothetical protein; Provisional; Region: PRK10579 536056001206 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 536056001207 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 536056001208 fructokinase; Reviewed; Region: PRK09557 536056001209 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 536056001210 nucleotide binding site [chemical binding]; other site 536056001211 MFS transport protein AraJ; Provisional; Region: PRK10091 536056001212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056001213 putative substrate translocation pore; other site 536056001214 exonuclease subunit SbcC; Provisional; Region: PRK10246 536056001215 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536056001216 Walker A/P-loop; other site 536056001217 ATP binding site [chemical binding]; other site 536056001218 Q-loop/lid; other site 536056001219 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536056001220 ABC transporter signature motif; other site 536056001221 Walker B; other site 536056001222 D-loop; other site 536056001223 H-loop/switch region; other site 536056001224 exonuclease subunit SbcD; Provisional; Region: PRK10966 536056001225 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 536056001226 active site 536056001227 metal binding site [ion binding]; metal-binding site 536056001228 DNA binding site [nucleotide binding] 536056001229 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 536056001230 transcriptional regulator PhoB; Provisional; Region: PRK10161 536056001231 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536056001232 active site 536056001233 phosphorylation site [posttranslational modification] 536056001234 intermolecular recognition site; other site 536056001235 dimerization interface [polypeptide binding]; other site 536056001236 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 536056001237 DNA binding site [nucleotide binding] 536056001238 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 536056001239 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 536056001240 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536056001241 putative active site [active] 536056001242 heme pocket [chemical binding]; other site 536056001243 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536056001244 dimer interface [polypeptide binding]; other site 536056001245 phosphorylation site [posttranslational modification] 536056001246 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536056001247 ATP binding site [chemical binding]; other site 536056001248 Mg2+ binding site [ion binding]; other site 536056001249 G-X-G motif; other site 536056001250 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 536056001251 putative proline-specific permease; Provisional; Region: proY; PRK10580 536056001252 Spore germination protein; Region: Spore_permease; cl17796 536056001253 maltodextrin glucosidase; Provisional; Region: PRK10785 536056001254 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 536056001255 homodimer interface [polypeptide binding]; other site 536056001256 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 536056001257 active site 536056001258 homodimer interface [polypeptide binding]; other site 536056001259 catalytic site [active] 536056001260 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 536056001261 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 536056001262 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 536056001263 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 536056001264 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 536056001265 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 536056001266 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 536056001267 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 536056001268 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 536056001269 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 536056001270 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 536056001271 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 536056001272 Protein export membrane protein; Region: SecD_SecF; pfam02355 536056001273 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 536056001274 active site 536056001275 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 536056001276 hypothetical protein; Provisional; Region: PRK11530 536056001277 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 536056001278 ATP cone domain; Region: ATP-cone; pfam03477 536056001279 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 536056001280 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 536056001281 catalytic motif [active] 536056001282 Zn binding site [ion binding]; other site 536056001283 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 536056001284 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 536056001285 homopentamer interface [polypeptide binding]; other site 536056001286 active site 536056001287 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 536056001288 putative RNA binding site [nucleotide binding]; other site 536056001289 thiamine monophosphate kinase; Provisional; Region: PRK05731 536056001290 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 536056001291 ATP binding site [chemical binding]; other site 536056001292 dimerization interface [polypeptide binding]; other site 536056001293 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 536056001294 tetramer interfaces [polypeptide binding]; other site 536056001295 binuclear metal-binding site [ion binding]; other site 536056001296 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 536056001297 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 536056001298 active site 536056001299 catalytic tetrad [active] 536056001300 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 536056001301 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 536056001302 TPP-binding site; other site 536056001303 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 536056001304 PYR/PP interface [polypeptide binding]; other site 536056001305 dimer interface [polypeptide binding]; other site 536056001306 TPP binding site [chemical binding]; other site 536056001307 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 536056001308 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 536056001309 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 536056001310 substrate binding pocket [chemical binding]; other site 536056001311 chain length determination region; other site 536056001312 substrate-Mg2+ binding site; other site 536056001313 catalytic residues [active] 536056001314 aspartate-rich region 1; other site 536056001315 active site lid residues [active] 536056001316 aspartate-rich region 2; other site 536056001317 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 536056001318 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 536056001319 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 536056001320 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 536056001321 Ligand Binding Site [chemical binding]; other site 536056001322 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 536056001323 active site residue [active] 536056001324 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 536056001325 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 536056001326 conserved cys residue [active] 536056001327 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 536056001328 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 536056001329 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 536056001330 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 536056001331 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 536056001332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056001333 Major Facilitator Superfamily; Region: MFS_1; pfam07690 536056001334 putative substrate translocation pore; other site 536056001335 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 536056001336 UbiA prenyltransferase family; Region: UbiA; pfam01040 536056001337 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 536056001338 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 536056001339 Subunit I/III interface [polypeptide binding]; other site 536056001340 Subunit III/IV interface [polypeptide binding]; other site 536056001341 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 536056001342 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 536056001343 D-pathway; other site 536056001344 Putative ubiquinol binding site [chemical binding]; other site 536056001345 Low-spin heme (heme b) binding site [chemical binding]; other site 536056001346 Putative water exit pathway; other site 536056001347 Binuclear center (heme o3/CuB) [ion binding]; other site 536056001348 K-pathway; other site 536056001349 Putative proton exit pathway; other site 536056001350 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 536056001351 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 536056001352 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 536056001353 muropeptide transporter; Reviewed; Region: ampG; PRK11902 536056001354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056001355 putative substrate translocation pore; other site 536056001356 hypothetical protein; Provisional; Region: PRK11627 536056001357 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 536056001358 transcriptional regulator BolA; Provisional; Region: PRK11628 536056001359 trigger factor; Provisional; Region: tig; PRK01490 536056001360 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 536056001361 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 536056001362 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 536056001363 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 536056001364 oligomer interface [polypeptide binding]; other site 536056001365 active site residues [active] 536056001366 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 536056001367 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 536056001368 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536056001369 Walker A motif; other site 536056001370 ATP binding site [chemical binding]; other site 536056001371 Walker B motif; other site 536056001372 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 536056001373 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 536056001374 Found in ATP-dependent protease La (LON); Region: LON; smart00464 536056001375 Found in ATP-dependent protease La (LON); Region: LON; smart00464 536056001376 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536056001377 Walker A motif; other site 536056001378 ATP binding site [chemical binding]; other site 536056001379 Walker B motif; other site 536056001380 arginine finger; other site 536056001381 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 536056001382 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 536056001383 IHF dimer interface [polypeptide binding]; other site 536056001384 IHF - DNA interface [nucleotide binding]; other site 536056001385 periplasmic folding chaperone; Provisional; Region: PRK10788 536056001386 SurA N-terminal domain; Region: SurA_N_3; cl07813 536056001387 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 536056001388 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 536056001389 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 536056001390 active site 536056001391 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 536056001392 Ligand Binding Site [chemical binding]; other site 536056001393 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 536056001394 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 536056001395 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 536056001396 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 536056001397 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536056001398 active site 536056001399 motif I; other site 536056001400 motif II; other site 536056001401 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 536056001402 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536056001403 putative DNA binding site [nucleotide binding]; other site 536056001404 putative Zn2+ binding site [ion binding]; other site 536056001405 AsnC family; Region: AsnC_trans_reg; pfam01037 536056001406 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 536056001407 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 536056001408 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536056001409 Walker A/P-loop; other site 536056001410 ATP binding site [chemical binding]; other site 536056001411 Q-loop/lid; other site 536056001412 ABC transporter signature motif; other site 536056001413 Walker B; other site 536056001414 D-loop; other site 536056001415 H-loop/switch region; other site 536056001416 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 536056001417 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 536056001418 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 536056001419 Walker A/P-loop; other site 536056001420 ATP binding site [chemical binding]; other site 536056001421 Q-loop/lid; other site 536056001422 ABC transporter signature motif; other site 536056001423 Walker B; other site 536056001424 D-loop; other site 536056001425 H-loop/switch region; other site 536056001426 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 536056001427 Nitrogen regulatory protein P-II; Region: P-II; smart00938 536056001428 ammonium transporter; Provisional; Region: PRK10666 536056001429 acyl-CoA thioesterase II; Provisional; Region: PRK10526 536056001430 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 536056001431 active site 536056001432 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 536056001433 catalytic triad [active] 536056001434 dimer interface [polypeptide binding]; other site 536056001435 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 536056001436 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 536056001437 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 536056001438 DNA binding site [nucleotide binding] 536056001439 active site 536056001440 Uncharacterized conserved protein [Function unknown]; Region: COG5507 536056001441 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 536056001442 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 536056001443 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 536056001444 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 536056001445 maltose O-acetyltransferase; Provisional; Region: PRK10092 536056001446 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 536056001447 active site 536056001448 substrate binding site [chemical binding]; other site 536056001449 trimer interface [polypeptide binding]; other site 536056001450 CoA binding site [chemical binding]; other site 536056001451 gene expression modulator; Provisional; Region: PRK10945 536056001452 Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757 536056001453 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 536056001454 Protein export membrane protein; Region: SecD_SecF; cl14618 536056001455 Protein export membrane protein; Region: SecD_SecF; cl14618 536056001456 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 536056001457 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 536056001458 HlyD family secretion protein; Region: HlyD_3; pfam13437 536056001459 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 536056001460 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536056001461 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 536056001462 hypothetical protein; Provisional; Region: PRK11281 536056001463 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 536056001464 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 536056001465 Mechanosensitive ion channel; Region: MS_channel; pfam00924 536056001466 hypothetical protein; Provisional; Region: PRK11038 536056001467 primosomal replication protein N''; Provisional; Region: PRK10093 536056001468 hypothetical protein; Provisional; Region: PRK10527 536056001469 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 536056001470 active site 536056001471 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 536056001472 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536056001473 Walker A motif; other site 536056001474 ATP binding site [chemical binding]; other site 536056001475 Walker B motif; other site 536056001476 DNA polymerase III subunit delta'; Validated; Region: PRK08485 536056001477 arginine finger; other site 536056001478 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 536056001479 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 536056001480 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 536056001481 hypothetical protein; Validated; Region: PRK00153 536056001482 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 536056001483 RecR protein; Region: RecR; pfam02132 536056001484 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 536056001485 putative active site [active] 536056001486 putative metal-binding site [ion binding]; other site 536056001487 tetramer interface [polypeptide binding]; other site 536056001488 heat shock protein 90; Provisional; Region: PRK05218 536056001489 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536056001490 ATP binding site [chemical binding]; other site 536056001491 Mg2+ binding site [ion binding]; other site 536056001492 G-X-G motif; other site 536056001493 adenylate kinase; Reviewed; Region: adk; PRK00279 536056001494 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 536056001495 AMP-binding site [chemical binding]; other site 536056001496 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 536056001497 ferrochelatase; Region: hemH; TIGR00109 536056001498 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 536056001499 C-terminal domain interface [polypeptide binding]; other site 536056001500 active site 536056001501 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 536056001502 active site 536056001503 N-terminal domain interface [polypeptide binding]; other site 536056001504 acetyl esterase; Provisional; Region: PRK10162 536056001505 inosine/guanosine kinase; Provisional; Region: PRK15074 536056001506 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 536056001507 putative cation:proton antiport protein; Provisional; Region: PRK10669 536056001508 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 536056001509 TrkA-N domain; Region: TrkA_N; pfam02254 536056001510 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056001511 Major Facilitator Superfamily; Region: MFS_1; pfam07690 536056001512 putative substrate translocation pore; other site 536056001513 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 536056001514 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 536056001515 active site 536056001516 metal binding site [ion binding]; metal-binding site 536056001517 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 536056001518 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 536056001519 putative deacylase active site [active] 536056001520 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 536056001521 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 536056001522 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536056001523 non-specific DNA binding site [nucleotide binding]; other site 536056001524 salt bridge; other site 536056001525 sequence-specific DNA binding site [nucleotide binding]; other site 536056001526 copper exporting ATPase; Provisional; Region: copA; PRK10671 536056001527 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 536056001528 metal-binding site [ion binding] 536056001529 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 536056001530 metal-binding site [ion binding] 536056001531 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 536056001532 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536056001533 motif II; other site 536056001534 glutaminase; Reviewed; Region: PRK12356 536056001535 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 536056001536 amino acid transporter; Region: 2A0306; TIGR00909 536056001537 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 536056001538 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 536056001539 DNA binding residues [nucleotide binding] 536056001540 dimer interface [polypeptide binding]; other site 536056001541 copper binding site [ion binding]; other site 536056001542 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 536056001543 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 536056001544 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 536056001545 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 536056001546 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536056001547 Walker A/P-loop; other site 536056001548 ATP binding site [chemical binding]; other site 536056001549 Q-loop/lid; other site 536056001550 ABC transporter signature motif; other site 536056001551 Walker B; other site 536056001552 D-loop; other site 536056001553 H-loop/switch region; other site 536056001554 Uncharacterized protein family (UPF0014); Region: UPF0014; pfam03649 536056001555 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 536056001556 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 536056001557 oxidoreductase; Provisional; Region: PRK08017 536056001558 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 536056001559 NADP binding site [chemical binding]; other site 536056001560 active site 536056001561 steroid binding site; other site 536056001562 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 536056001563 active site 536056001564 catalytic triad [active] 536056001565 oxyanion hole [active] 536056001566 switch loop; other site 536056001567 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 536056001568 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 536056001569 Walker A/P-loop; other site 536056001570 ATP binding site [chemical binding]; other site 536056001571 Q-loop/lid; other site 536056001572 ABC transporter signature motif; other site 536056001573 Walker B; other site 536056001574 D-loop; other site 536056001575 H-loop/switch region; other site 536056001576 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 536056001577 FtsX-like permease family; Region: FtsX; pfam02687 536056001578 FtsX-like permease family; Region: FtsX; pfam02687 536056001579 PAAR motif; Region: PAAR_motif; cl15808 536056001580 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 536056001581 RHS Repeat; Region: RHS_repeat; pfam05593 536056001582 RHS Repeat; Region: RHS_repeat; pfam05593 536056001583 RHS Repeat; Region: RHS_repeat; pfam05593 536056001584 RHS Repeat; Region: RHS_repeat; pfam05593 536056001585 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 536056001586 RHS Repeat; Region: RHS_repeat; pfam05593 536056001587 RHS Repeat; Region: RHS_repeat; pfam05593 536056001588 RHS protein; Region: RHS; pfam03527 536056001589 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 536056001590 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 536056001591 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 536056001592 RHS protein; Region: RHS; pfam03527 536056001593 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 536056001594 hypothetical protein; Provisional; Region: PRK14710 536056001595 Winged helix-turn helix; Region: HTH_29; pfam13551 536056001596 Helix-turn-helix domain; Region: HTH_28; pfam13518 536056001597 Predicted ATPase [General function prediction only]; Region: COG2603 536056001598 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 536056001599 active site residue [active] 536056001600 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 536056001601 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056001602 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 536056001603 dimerization interface [polypeptide binding]; other site 536056001604 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 536056001605 ureidoglycolate hydrolase; Provisional; Region: PRK03606 536056001606 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 536056001607 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 536056001608 Bacterial transcriptional regulator; Region: IclR; pfam01614 536056001609 glyoxylate carboligase; Provisional; Region: PRK11269 536056001610 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 536056001611 PYR/PP interface [polypeptide binding]; other site 536056001612 dimer interface [polypeptide binding]; other site 536056001613 TPP binding site [chemical binding]; other site 536056001614 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 536056001615 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 536056001616 TPP-binding site [chemical binding]; other site 536056001617 hydroxypyruvate isomerase; Provisional; Region: PRK09997 536056001618 tartronate semialdehyde reductase; Provisional; Region: PRK15059 536056001619 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 536056001620 nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; Region: SLC-NCS1sbd; cd10323 536056001621 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 536056001622 Na binding site [ion binding]; other site 536056001623 substrate binding site [chemical binding]; other site 536056001624 allantoinase; Provisional; Region: PRK08044 536056001625 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 536056001626 active site 536056001627 putative uracil/xanthine transporter; Provisional; Region: PRK11412 536056001628 glycerate kinase II; Provisional; Region: PRK09932 536056001629 putative allantoin catabolism protein; Region: ura-cupin; TIGR03214 536056001630 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 536056001631 Cupin domain; Region: Cupin_2; cl17218 536056001632 allantoate amidohydrolase; Region: AllC; TIGR03176 536056001633 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 536056001634 active site 536056001635 metal binding site [ion binding]; metal-binding site 536056001636 dimer interface [polypeptide binding]; other site 536056001637 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 536056001638 membrane protein FdrA; Validated; Region: PRK06091 536056001639 CoA binding domain; Region: CoA_binding; pfam02629 536056001640 CoA-ligase; Region: Ligase_CoA; pfam00549 536056001641 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 536056001642 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 536056001643 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 536056001644 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 536056001645 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 536056001646 putative substrate binding site [chemical binding]; other site 536056001647 nucleotide binding site [chemical binding]; other site 536056001648 nucleotide binding site [chemical binding]; other site 536056001649 homodimer interface [polypeptide binding]; other site 536056001650 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 536056001651 ATP-grasp domain; Region: ATP-grasp; pfam02222 536056001652 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 536056001653 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 536056001654 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 536056001655 putative active site [active] 536056001656 putative metal binding site [ion binding]; other site 536056001657 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 536056001658 substrate binding site [chemical binding]; other site 536056001659 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 536056001660 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 536056001661 active site 536056001662 HIGH motif; other site 536056001663 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 536056001664 KMSKS motif; other site 536056001665 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 536056001666 tRNA binding surface [nucleotide binding]; other site 536056001667 anticodon binding site; other site 536056001668 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 536056001669 ribosome-associated protein; Provisional; Region: PRK11507 536056001670 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 536056001671 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 536056001672 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 536056001673 homodimer interface [polypeptide binding]; other site 536056001674 NADP binding site [chemical binding]; other site 536056001675 substrate binding site [chemical binding]; other site 536056001676 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 536056001677 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 536056001678 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 536056001679 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 536056001680 outer membrane usher protein FimD; Provisional; Region: PRK15198 536056001681 PapC N-terminal domain; Region: PapC_N; pfam13954 536056001682 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 536056001683 PapC C-terminal domain; Region: PapC_C; pfam13953 536056001684 fimbrial-like adhesin; Provisional; Region: fimH; PRK15199 536056001685 fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934 536056001686 transcriptional regulator FimZ; Provisional; Region: PRK09935 536056001687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536056001688 active site 536056001689 phosphorylation site [posttranslational modification] 536056001690 intermolecular recognition site; other site 536056001691 dimerization interface [polypeptide binding]; other site 536056001692 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536056001693 DNA binding residues [nucleotide binding] 536056001694 dimerization interface [polypeptide binding]; other site 536056001695 'DLP12 prophage; predicted integrase, missing start codon due to a deletion' 536056001696 Transposase domain (DUF772); Region: DUF772; pfam05598 536056001697 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 536056001698 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 536056001699 Lysis protein S; Region: Lysis_S; pfam04971 536056001700 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 536056001701 catalytic residues [active] 536056001702 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 536056001703 Bor protein; Region: Lambda_Bor; pfam06291 536056001704 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 536056001705 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 536056001706 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 536056001707 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 536056001708 Methyltransferase domain; Region: Methyltransf_12; pfam08242 536056001709 S-adenosylmethionine binding site [chemical binding]; other site 536056001710 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 536056001711 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 536056001712 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536056001713 outer membrane protease; Reviewed; Region: PRK10993 536056001714 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 536056001715 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536056001716 hypothetical protein; Provisional; Region: PRK09936 536056001717 bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782 536056001718 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536056001719 TPR motif; other site 536056001720 binding surface 536056001721 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 536056001722 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 536056001723 active site 536056001724 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 536056001725 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 536056001726 sensor kinase CusS; Provisional; Region: PRK09835 536056001727 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 536056001728 dimerization interface [polypeptide binding]; other site 536056001729 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536056001730 dimer interface [polypeptide binding]; other site 536056001731 phosphorylation site [posttranslational modification] 536056001732 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536056001733 ATP binding site [chemical binding]; other site 536056001734 Mg2+ binding site [ion binding]; other site 536056001735 G-X-G motif; other site 536056001736 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 536056001737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536056001738 active site 536056001739 phosphorylation site [posttranslational modification] 536056001740 intermolecular recognition site; other site 536056001741 dimerization interface [polypeptide binding]; other site 536056001742 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 536056001743 DNA binding site [nucleotide binding] 536056001744 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 536056001745 periplasmic copper-binding protein; Provisional; Region: PRK09838 536056001746 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 536056001747 HlyD family secretion protein; Region: HlyD_3; pfam13437 536056001748 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 536056001749 phenylalanine transporter; Provisional; Region: PRK10249 536056001750 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 536056001751 Mechanosensitive ion channel; Region: MS_channel; pfam00924 536056001752 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 536056001753 dimer interface [polypeptide binding]; other site 536056001754 FMN binding site [chemical binding]; other site 536056001755 hypothetical protein; Provisional; Region: PRK10250 536056001756 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 536056001757 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 536056001758 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 536056001759 Hok/gef family; Region: HOK_GEF; pfam01848 536056001760 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 536056001761 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 536056001762 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 536056001763 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 536056001764 outer membrane receptor FepA; Provisional; Region: PRK13524 536056001765 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 536056001766 N-terminal plug; other site 536056001767 ligand-binding site [chemical binding]; other site 536056001768 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 536056001769 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 536056001770 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 536056001771 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 536056001772 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 536056001773 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 536056001774 acyl-activating enzyme (AAE) consensus motif; other site 536056001775 AMP binding site [chemical binding]; other site 536056001776 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 536056001777 LPS O-antigen length regulator; Provisional; Region: PRK10381 536056001778 Chain length determinant protein; Region: Wzz; pfam02706 536056001779 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 536056001780 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 536056001781 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 536056001782 Walker A/P-loop; other site 536056001783 ATP binding site [chemical binding]; other site 536056001784 Q-loop/lid; other site 536056001785 ABC transporter signature motif; other site 536056001786 Walker B; other site 536056001787 D-loop; other site 536056001788 H-loop/switch region; other site 536056001789 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 536056001790 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 536056001791 ABC-ATPase subunit interface; other site 536056001792 dimer interface [polypeptide binding]; other site 536056001793 putative PBP binding regions; other site 536056001794 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 536056001795 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 536056001796 ABC-ATPase subunit interface; other site 536056001797 dimer interface [polypeptide binding]; other site 536056001798 putative PBP binding regions; other site 536056001799 enterobactin exporter EntS; Provisional; Region: PRK10489 536056001800 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056001801 putative substrate translocation pore; other site 536056001802 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 536056001803 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 536056001804 siderophore binding site; other site 536056001805 isochorismate synthase EntC; Provisional; Region: PRK15016 536056001806 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 536056001807 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 536056001808 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 536056001809 acyl-activating enzyme (AAE) consensus motif; other site 536056001810 active site 536056001811 AMP binding site [chemical binding]; other site 536056001812 substrate binding site [chemical binding]; other site 536056001813 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 536056001814 hydrophobic substrate binding pocket; other site 536056001815 Isochorismatase family; Region: Isochorismatase; pfam00857 536056001816 active site 536056001817 conserved cis-peptide bond; other site 536056001818 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 536056001819 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 536056001820 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 536056001821 putative NAD(P) binding site [chemical binding]; other site 536056001822 active site 536056001823 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 536056001824 CoenzymeA binding site [chemical binding]; other site 536056001825 subunit interaction site [polypeptide binding]; other site 536056001826 PHB binding site; other site 536056001827 carbon starvation protein A; Provisional; Region: PRK15015 536056001828 Carbon starvation protein CstA; Region: CstA; pfam02554 536056001829 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 536056001830 Uncharacterized small protein [Function unknown]; Region: COG2879 536056001831 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 536056001832 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 536056001833 putative active site [active] 536056001834 metal binding site [ion binding]; metal-binding site 536056001835 methionine aminotransferase; Validated; Region: PRK09082 536056001836 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 536056001837 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056001838 homodimer interface [polypeptide binding]; other site 536056001839 catalytic residue [active] 536056001840 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 536056001841 ParB-like nuclease domain; Region: ParBc; pfam02195 536056001842 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 536056001843 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 536056001844 Active Sites [active] 536056001845 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 536056001846 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 536056001847 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056001848 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 536056001849 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 536056001850 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 536056001851 dimerization domain [polypeptide binding]; other site 536056001852 dimer interface [polypeptide binding]; other site 536056001853 catalytic residues [active] 536056001854 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 536056001855 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 536056001856 dimer interface [polypeptide binding]; other site 536056001857 decamer (pentamer of dimers) interface [polypeptide binding]; other site 536056001858 catalytic triad [active] 536056001859 peroxidatic and resolving cysteines [active] 536056001860 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 536056001861 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 536056001862 catalytic residue [active] 536056001863 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 536056001864 catalytic residues [active] 536056001865 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 536056001866 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 536056001867 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 536056001868 Ligand Binding Site [chemical binding]; other site 536056001869 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 536056001870 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 536056001871 NAD binding site [chemical binding]; other site 536056001872 catalytic Zn binding site [ion binding]; other site 536056001873 structural Zn binding site [ion binding]; other site 536056001874 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 536056001875 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 536056001876 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 536056001877 B1 nucleotide binding pocket [chemical binding]; other site 536056001878 B2 nucleotide binding pocket [chemical binding]; other site 536056001879 CAS motifs; other site 536056001880 active site 536056001881 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 536056001882 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 536056001883 transmembrane helices; other site 536056001884 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 536056001885 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 536056001886 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 536056001887 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 536056001888 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 536056001889 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 536056001890 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 536056001891 putative active site [active] 536056001892 (T/H)XGH motif; other site 536056001893 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 536056001894 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536056001895 putative active site [active] 536056001896 heme pocket [chemical binding]; other site 536056001897 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536056001898 ATP binding site [chemical binding]; other site 536056001899 Mg2+ binding site [ion binding]; other site 536056001900 G-X-G motif; other site 536056001901 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 536056001902 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536056001903 active site 536056001904 phosphorylation site [posttranslational modification] 536056001905 intermolecular recognition site; other site 536056001906 dimerization interface [polypeptide binding]; other site 536056001907 Transcriptional regulator; Region: CitT; pfam12431 536056001908 'anaerobic C4-dicarboxylate transport, pseudogene fragment' 536056001909 'anaerobic C4-dicarboxylate transport, pseudogene fragment' 536056001910 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 536056001911 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 536056001912 DNA-binding site [nucleotide binding]; DNA binding site 536056001913 RNA-binding motif; other site 536056001914 chromosome condensation membrane protein; Provisional; Region: PRK14196 536056001915 potential frameshift: common BLAST hit: gi|378713994|ref|YP_005278887.1| nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase 536056001916 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 536056001917 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 536056001918 Predicted amidohydrolase [General function prediction only]; Region: COG0388 536056001919 active site 536056001920 catalytic triad [active] 536056001921 dimer interface [polypeptide binding]; other site 536056001922 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 536056001923 lipoyl synthase; Provisional; Region: PRK05481 536056001924 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 536056001925 FeS/SAM binding site; other site 536056001926 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 536056001927 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056001928 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 536056001929 substrate binding pocket [chemical binding]; other site 536056001930 dimerization interface [polypeptide binding]; other site 536056001931 lipoate-protein ligase B; Provisional; Region: PRK14342 536056001932 hypothetical protein; Provisional; Region: PRK04998 536056001933 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 536056001934 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 536056001935 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 536056001936 rare lipoprotein A; Provisional; Region: PRK10672 536056001937 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 536056001938 Sporulation related domain; Region: SPOR; pfam05036 536056001939 cell wall shape-determining protein; Provisional; Region: PRK10794 536056001940 penicillin-binding protein 2; Provisional; Region: PRK10795 536056001941 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 536056001942 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 536056001943 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 536056001944 ribosome-associated protein; Provisional; Region: PRK11538 536056001945 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 536056001946 catalytic core [active] 536056001947 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 536056001948 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 536056001949 active site 536056001950 (T/H)XGH motif; other site 536056001951 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 536056001952 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 536056001953 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 536056001954 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 536056001955 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 536056001956 HIGH motif; other site 536056001957 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 536056001958 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 536056001959 active site 536056001960 KMSKS motif; other site 536056001961 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 536056001962 tRNA binding surface [nucleotide binding]; other site 536056001963 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 536056001964 hypothetical protein; Provisional; Region: PRK11032 536056001965 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 536056001966 Sel1-like repeats; Region: SEL1; smart00671 536056001967 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 536056001968 Sel1-like repeats; Region: SEL1; smart00671 536056001969 Sel1-like repeats; Region: SEL1; smart00671 536056001970 Sel1-like repeats; Region: SEL1; smart00671 536056001971 Sel1-like repeats; Region: SEL1; smart00671 536056001972 Sel1-like repeats; Region: SEL1; smart00671 536056001973 Sel1-like repeats; Region: SEL1; smart00671 536056001974 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 536056001975 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 536056001976 HSP70 interaction site [polypeptide binding]; other site 536056001977 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 536056001978 Sel1-like repeats; Region: SEL1; smart00671 536056001979 Sel1-like repeats; Region: SEL1; smart00671 536056001980 Sel1 repeat; Region: Sel1; cl02723 536056001981 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 536056001982 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 536056001983 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 536056001984 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 536056001985 nucleotide binding site [chemical binding]; other site 536056001986 putative NEF/HSP70 interaction site [polypeptide binding]; other site 536056001987 SBD interface [polypeptide binding]; other site 536056001988 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 536056001989 active site 536056001990 tetramer interface [polypeptide binding]; other site 536056001991 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 536056001992 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 536056001993 Walker A/P-loop; other site 536056001994 ATP binding site [chemical binding]; other site 536056001995 Q-loop/lid; other site 536056001996 ABC transporter signature motif; other site 536056001997 Walker B; other site 536056001998 D-loop; other site 536056001999 H-loop/switch region; other site 536056002000 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 536056002001 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056002002 dimer interface [polypeptide binding]; other site 536056002003 conserved gate region; other site 536056002004 putative PBP binding loops; other site 536056002005 ABC-ATPase subunit interface; other site 536056002006 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 536056002007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056002008 dimer interface [polypeptide binding]; other site 536056002009 conserved gate region; other site 536056002010 putative PBP binding loops; other site 536056002011 ABC-ATPase subunit interface; other site 536056002012 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 536056002013 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536056002014 substrate binding pocket [chemical binding]; other site 536056002015 membrane-bound complex binding site; other site 536056002016 hinge residues; other site 536056002017 Transposase domain (DUF772); Region: DUF772; pfam05598 536056002018 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 536056002019 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 536056002020 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 536056002021 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 536056002022 putative active site [active] 536056002023 catalytic triad [active] 536056002024 putative dimer interface [polypeptide binding]; other site 536056002025 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 536056002026 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 536056002027 Transporter associated domain; Region: CorC_HlyC; smart01091 536056002028 metal-binding heat shock protein; Provisional; Region: PRK00016 536056002029 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 536056002030 PhoH-like protein; Region: PhoH; pfam02562 536056002031 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 536056002032 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 536056002033 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 536056002034 FeS/SAM binding site; other site 536056002035 TRAM domain; Region: TRAM; pfam01938 536056002036 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 536056002037 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 536056002038 asparagine synthetase B; Provisional; Region: asnB; PRK09431 536056002039 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 536056002040 active site 536056002041 dimer interface [polypeptide binding]; other site 536056002042 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 536056002043 Ligand Binding Site [chemical binding]; other site 536056002044 Molecular Tunnel; other site 536056002045 UMP phosphatase; Provisional; Region: PRK10444 536056002046 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536056002047 active site 536056002048 motif I; other site 536056002049 motif II; other site 536056002050 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536056002051 MarR family; Region: MarR; pfam01047 536056002052 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 536056002053 ROK family; Region: ROK; pfam00480 536056002054 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 536056002055 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 536056002056 active site 536056002057 dimer interface [polypeptide binding]; other site 536056002058 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 536056002059 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 536056002060 active site 536056002061 trimer interface [polypeptide binding]; other site 536056002062 allosteric site; other site 536056002063 active site lid [active] 536056002064 hexamer (dimer of trimers) interface [polypeptide binding]; other site 536056002065 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 536056002066 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 536056002067 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 536056002068 active site turn [active] 536056002069 phosphorylation site [posttranslational modification] 536056002070 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 536056002071 HPr interaction site; other site 536056002072 glycerol kinase (GK) interaction site [polypeptide binding]; other site 536056002073 active site 536056002074 phosphorylation site [posttranslational modification] 536056002075 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 536056002076 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 536056002077 active site 536056002078 HIGH motif; other site 536056002079 nucleotide binding site [chemical binding]; other site 536056002080 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 536056002081 KMSKS motif; other site 536056002082 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 536056002083 outer membrane porin, OprD family; Region: OprD; pfam03573 536056002084 YbfN-like lipoprotein; Region: YbfN; pfam13982 536056002085 ferric uptake regulator; Provisional; Region: fur; PRK09462 536056002086 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 536056002087 metal binding site 2 [ion binding]; metal-binding site 536056002088 putative DNA binding helix; other site 536056002089 metal binding site 1 [ion binding]; metal-binding site 536056002090 dimer interface [polypeptide binding]; other site 536056002091 structural Zn2+ binding site [ion binding]; other site 536056002092 flavodoxin FldA; Validated; Region: PRK09267 536056002093 LexA regulated protein; Provisional; Region: PRK11675 536056002094 acyl-CoA esterase; Provisional; Region: PRK10673 536056002095 PGAP1-like protein; Region: PGAP1; pfam07819 536056002096 replication initiation regulator SeqA; Provisional; Region: PRK11187 536056002097 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 536056002098 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 536056002099 active site 536056002100 substrate binding site [chemical binding]; other site 536056002101 metal binding site [ion binding]; metal-binding site 536056002102 Protein of unknown function DUF2625; Region: DUF2625; cl08177 536056002103 Protein of unknown function DUF2625; Region: DUF2625; cl08177 536056002104 putrescine transporter; Provisional; Region: potE; PRK10655 536056002105 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 536056002106 ornithine decarboxylase; Provisional; Region: PRK13578 536056002107 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 536056002108 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 536056002109 homodimer interface [polypeptide binding]; other site 536056002110 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056002111 catalytic residue [active] 536056002112 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 536056002113 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 536056002114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536056002115 active site 536056002116 phosphorylation site [posttranslational modification] 536056002117 intermolecular recognition site; other site 536056002118 dimerization interface [polypeptide binding]; other site 536056002119 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 536056002120 DNA binding site [nucleotide binding] 536056002121 sensor protein KdpD; Provisional; Region: PRK10490 536056002122 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 536056002123 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 536056002124 Ligand Binding Site [chemical binding]; other site 536056002125 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 536056002126 GAF domain; Region: GAF_3; pfam13492 536056002127 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536056002128 dimer interface [polypeptide binding]; other site 536056002129 phosphorylation site [posttranslational modification] 536056002130 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536056002131 ATP binding site [chemical binding]; other site 536056002132 Mg2+ binding site [ion binding]; other site 536056002133 G-X-G motif; other site 536056002134 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 536056002135 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 536056002136 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 536056002137 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 536056002138 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 536056002139 PAAR motif; Region: PAAR_motif; cl15808 536056002140 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 536056002141 RHS Repeat; Region: RHS_repeat; pfam05593 536056002142 RHS Repeat; Region: RHS_repeat; pfam05593 536056002143 RHS Repeat; Region: RHS_repeat; pfam05593 536056002144 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 536056002145 RHS Repeat; Region: RHS_repeat; pfam05593 536056002146 RHS Repeat; Region: RHS_repeat; pfam05593 536056002147 RHS protein; Region: RHS; pfam03527 536056002148 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 536056002149 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 536056002150 RHS protein; Region: RHS; pfam03527 536056002151 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 536056002152 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 536056002153 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 536056002154 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 536056002155 Transposase [DNA replication, recombination, and repair]; Region: COG5433 536056002156 hypothetical protein; Provisional; Region: PRK10167 536056002157 Uncharacterized conserved protein [Function unknown]; Region: COG3272 536056002158 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 536056002159 DNA photolyase; Region: DNA_photolyase; pfam00875 536056002160 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 536056002161 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056002162 putative substrate translocation pore; other site 536056002163 POT family; Region: PTR2; pfam00854 536056002164 Uncharacterized conserved protein [Function unknown]; Region: COG0327 536056002165 metal-binding protein; Provisional; Region: PRK10799 536056002166 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 536056002167 sensor histidine kinase inhibitor, KipI family; Region: TIGR00370 536056002168 biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724 536056002169 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 536056002170 putative active site [active] 536056002171 endonuclease VIII; Provisional; Region: PRK10445 536056002172 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 536056002173 DNA binding site [nucleotide binding] 536056002174 catalytic residue [active] 536056002175 putative catalytic residues [active] 536056002176 H2TH interface [polypeptide binding]; other site 536056002177 intercalation triad [nucleotide binding]; other site 536056002178 substrate specificity determining residue; other site 536056002179 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 536056002180 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 536056002181 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 536056002182 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 536056002183 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 536056002184 Fimbrial protein; Region: Fimbrial; pfam00419 536056002185 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 536056002186 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 536056002187 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 536056002188 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 536056002189 PapC N-terminal domain; Region: PapC_N; pfam13954 536056002190 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 536056002191 PapC C-terminal domain; Region: PapC_C; pfam13953 536056002192 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 536056002193 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 536056002194 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 536056002195 dimer interface [polypeptide binding]; other site 536056002196 active site 536056002197 citrylCoA binding site [chemical binding]; other site 536056002198 NADH binding [chemical binding]; other site 536056002199 cationic pore residues; other site 536056002200 oxalacetate/citrate binding site [chemical binding]; other site 536056002201 coenzyme A binding site [chemical binding]; other site 536056002202 catalytic triad [active] 536056002203 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 536056002204 Iron-sulfur protein interface; other site 536056002205 proximal quinone binding site [chemical binding]; other site 536056002206 SdhD (CybS) interface [polypeptide binding]; other site 536056002207 proximal heme binding site [chemical binding]; other site 536056002208 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 536056002209 SdhC subunit interface [polypeptide binding]; other site 536056002210 proximal heme binding site [chemical binding]; other site 536056002211 cardiolipin binding site; other site 536056002212 Iron-sulfur protein interface; other site 536056002213 proximal quinone binding site [chemical binding]; other site 536056002214 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 536056002215 L-aspartate oxidase; Provisional; Region: PRK06175 536056002216 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 536056002217 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 536056002218 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 536056002219 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 536056002220 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 536056002221 TPP-binding site [chemical binding]; other site 536056002222 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 536056002223 dimer interface [polypeptide binding]; other site 536056002224 PYR/PP interface [polypeptide binding]; other site 536056002225 TPP binding site [chemical binding]; other site 536056002226 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 536056002227 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 536056002228 E3 interaction surface; other site 536056002229 lipoyl attachment site [posttranslational modification]; other site 536056002230 e3 binding domain; Region: E3_binding; pfam02817 536056002231 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 536056002232 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 536056002233 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 536056002234 CoA-ligase; Region: Ligase_CoA; pfam00549 536056002235 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 536056002236 CoA binding domain; Region: CoA_binding; smart00881 536056002237 CoA-ligase; Region: Ligase_CoA; pfam00549 536056002238 DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764 536056002239 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536056002240 DNA-binding site [nucleotide binding]; DNA binding site 536056002241 UTRA domain; Region: UTRA; pfam07702 536056002242 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 536056002243 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 536056002244 active site 536056002245 phosphorylation site [posttranslational modification] 536056002246 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 536056002247 active site 536056002248 P-loop; other site 536056002249 phosphorylation site [posttranslational modification] 536056002250 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 536056002251 alpha-mannosidase; Provisional; Region: PRK09819 536056002252 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 536056002253 active site 536056002254 metal binding site [ion binding]; metal-binding site 536056002255 catalytic site [active] 536056002256 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 536056002257 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 536056002258 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 536056002259 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 536056002260 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 536056002261 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 536056002262 hypothetical protein; Provisional; Region: PRK10588 536056002263 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 536056002264 active site 536056002265 colicin uptake protein TolQ; Provisional; Region: PRK10801 536056002266 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 536056002267 colicin uptake protein TolR; Provisional; Region: PRK11024 536056002268 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 536056002269 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 536056002270 TolA C-terminal; Region: TolA; pfam06519 536056002271 translocation protein TolB; Provisional; Region: tolB; PRK03629 536056002272 TolB amino-terminal domain; Region: TolB_N; pfam04052 536056002273 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 536056002274 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 536056002275 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 536056002276 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 536056002277 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 536056002278 ligand binding site [chemical binding]; other site 536056002279 tol-pal system protein YbgF; Provisional; Region: PRK10803 536056002280 Tetratricopeptide repeat; Region: TPR_6; pfam13174 536056002281 Tetratricopeptide repeat; Region: TPR_6; pfam13174 536056002282 quinolinate synthetase; Provisional; Region: PRK09375 536056002283 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 536056002284 zinc transporter ZitB; Provisional; Region: PRK03557 536056002285 YbgS-like protein; Region: YbgS; pfam13985 536056002286 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 536056002287 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 536056002288 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 536056002289 catalytic core [active] 536056002290 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 536056002291 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 536056002292 active site 536056002293 catalytic residues [active] 536056002294 galactokinase; Provisional; Region: PRK05101 536056002295 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 536056002296 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 536056002297 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 536056002298 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 536056002299 dimer interface [polypeptide binding]; other site 536056002300 active site 536056002301 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 536056002302 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 536056002303 NAD binding site [chemical binding]; other site 536056002304 homodimer interface [polypeptide binding]; other site 536056002305 active site 536056002306 substrate binding site [chemical binding]; other site 536056002307 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 536056002308 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 536056002309 Walker A/P-loop; other site 536056002310 ATP binding site [chemical binding]; other site 536056002311 Q-loop/lid; other site 536056002312 ABC transporter signature motif; other site 536056002313 Walker B; other site 536056002314 D-loop; other site 536056002315 H-loop/switch region; other site 536056002316 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536056002317 Walker A/P-loop; other site 536056002318 ATP binding site [chemical binding]; other site 536056002319 Q-loop/lid; other site 536056002320 ABC transporter signature motif; other site 536056002321 Walker B; other site 536056002322 D-loop; other site 536056002323 H-loop/switch region; other site 536056002324 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 536056002325 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 536056002326 molybdenum-pterin binding domain; Region: Mop; TIGR00638 536056002327 TOBE domain; Region: TOBE; pfam03459 536056002328 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 536056002329 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 536056002330 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536056002331 substrate binding pocket [chemical binding]; other site 536056002332 membrane-bound complex binding site; other site 536056002333 hinge residues; other site 536056002334 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 536056002335 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056002336 putative PBP binding loops; other site 536056002337 ABC-ATPase subunit interface; other site 536056002338 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 536056002339 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536056002340 Walker A/P-loop; other site 536056002341 ATP binding site [chemical binding]; other site 536056002342 Q-loop/lid; other site 536056002343 ABC transporter signature motif; other site 536056002344 Walker B; other site 536056002345 D-loop; other site 536056002346 H-loop/switch region; other site 536056002347 molybdenum-pterin binding domain; Region: Mop; TIGR00638 536056002348 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 536056002349 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536056002350 motif II; other site 536056002351 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536056002352 6-phosphogluconolactonase; Provisional; Region: PRK11028 536056002353 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536056002354 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056002355 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 536056002356 putative dimerization interface [polypeptide binding]; other site 536056002357 PrpF protein; Region: PrpF; pfam04303 536056002358 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 536056002359 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 536056002360 transmembrane helices; other site 536056002361 putative hydratase; Provisional; Region: PRK11413 536056002362 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 536056002363 substrate binding site [chemical binding]; other site 536056002364 ligand binding site [chemical binding]; other site 536056002365 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 536056002366 substrate binding site [chemical binding]; other site 536056002367 acyl-CoA thioesterase; Provisional; Region: PRK10531 536056002368 putative pectinesterase; Region: PLN02432; cl01911 536056002369 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 536056002370 substrate binding site [chemical binding]; other site 536056002371 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 536056002372 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 536056002373 inhibitor-cofactor binding pocket; inhibition site 536056002374 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056002375 catalytic residue [active] 536056002376 biotin synthase; Provisional; Region: PRK15108 536056002377 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 536056002378 FeS/SAM binding site; other site 536056002379 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 536056002380 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 536056002381 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 536056002382 substrate-cofactor binding pocket; other site 536056002383 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056002384 catalytic residue [active] 536056002385 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 536056002386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536056002387 S-adenosylmethionine binding site [chemical binding]; other site 536056002388 AAA domain; Region: AAA_26; pfam13500 536056002389 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 536056002390 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 536056002391 ADP binding site [chemical binding]; other site 536056002392 excinuclease ABC subunit B; Provisional; Region: PRK05298 536056002393 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 536056002394 ATP binding site [chemical binding]; other site 536056002395 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 536056002396 nucleotide binding region [chemical binding]; other site 536056002397 ATP-binding site [chemical binding]; other site 536056002398 Ultra-violet resistance protein B; Region: UvrB; pfam12344 536056002399 UvrB/uvrC motif; Region: UVR; pfam02151 536056002400 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 536056002401 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 536056002402 putative substrate binding pocket [chemical binding]; other site 536056002403 dimer interface [polypeptide binding]; other site 536056002404 phosphate binding site [ion binding]; other site 536056002405 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 536056002406 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 536056002407 FeS/SAM binding site; other site 536056002408 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 536056002409 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 536056002410 MPT binding site; other site 536056002411 trimer interface [polypeptide binding]; other site 536056002412 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 536056002413 trimer interface [polypeptide binding]; other site 536056002414 dimer interface [polypeptide binding]; other site 536056002415 putative active site [active] 536056002416 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 536056002417 MoaE interaction surface [polypeptide binding]; other site 536056002418 MoeB interaction surface [polypeptide binding]; other site 536056002419 thiocarboxylated glycine; other site 536056002420 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 536056002421 MoaE homodimer interface [polypeptide binding]; other site 536056002422 MoaD interaction [polypeptide binding]; other site 536056002423 active site residues [active] 536056002424 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 536056002425 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 536056002426 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 536056002427 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 536056002428 Predicted integral membrane protein [Function unknown]; Region: COG0392 536056002429 cardiolipin synthase 2; Provisional; Region: PRK11263 536056002430 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 536056002431 putative active site [active] 536056002432 catalytic site [active] 536056002433 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 536056002434 putative active site [active] 536056002435 catalytic site [active] 536056002436 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 536056002437 putative catalytic site [active] 536056002438 putative metal binding site [ion binding]; other site 536056002439 putative phosphate binding site [ion binding]; other site 536056002440 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 536056002441 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 536056002442 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 536056002443 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 536056002444 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 536056002445 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 536056002446 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 536056002447 Walker A/P-loop; other site 536056002448 ATP binding site [chemical binding]; other site 536056002449 Q-loop/lid; other site 536056002450 ABC transporter signature motif; other site 536056002451 Walker B; other site 536056002452 D-loop; other site 536056002453 H-loop/switch region; other site 536056002454 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 536056002455 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 536056002456 Walker A/P-loop; other site 536056002457 ATP binding site [chemical binding]; other site 536056002458 Q-loop/lid; other site 536056002459 ABC transporter signature motif; other site 536056002460 Walker B; other site 536056002461 D-loop; other site 536056002462 H-loop/switch region; other site 536056002463 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 536056002464 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 536056002465 HlyD family secretion protein; Region: HlyD_3; pfam13437 536056002466 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 536056002467 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 536056002468 helicase 45; Provisional; Region: PTZ00424 536056002469 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 536056002470 ATP binding site [chemical binding]; other site 536056002471 Mg++ binding site [ion binding]; other site 536056002472 motif III; other site 536056002473 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 536056002474 nucleotide binding region [chemical binding]; other site 536056002475 ATP-binding site [chemical binding]; other site 536056002476 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3236 536056002477 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 536056002478 DEAD_2; Region: DEAD_2; pfam06733 536056002479 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 536056002480 glycosyl transferase family protein; Provisional; Region: PRK08136 536056002481 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 536056002482 putative dehydrogenase; Provisional; Region: PRK10098 536056002483 hypothetical protein; Provisional; Region: PRK10259 536056002484 hypothetical protein; Provisional; Region: PRK11019 536056002485 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 536056002486 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 536056002487 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 536056002488 N-terminal plug; other site 536056002489 ligand-binding site [chemical binding]; other site 536056002490 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 536056002491 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 536056002492 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 536056002493 putative mechanosensitive channel protein; Provisional; Region: PRK11465 536056002494 Mechanosensitive ion channel; Region: MS_channel; pfam00924 536056002495 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 536056002496 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 536056002497 Walker A/P-loop; other site 536056002498 ATP binding site [chemical binding]; other site 536056002499 Q-loop/lid; other site 536056002500 ABC transporter signature motif; other site 536056002501 Walker B; other site 536056002502 D-loop; other site 536056002503 H-loop/switch region; other site 536056002504 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 536056002505 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056002506 dimer interface [polypeptide binding]; other site 536056002507 conserved gate region; other site 536056002508 putative PBP binding loops; other site 536056002509 ABC-ATPase subunit interface; other site 536056002510 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 536056002511 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536056002512 substrate binding pocket [chemical binding]; other site 536056002513 membrane-bound complex binding site; other site 536056002514 hinge residues; other site 536056002515 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 536056002516 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 536056002517 dimerization interface [polypeptide binding]; other site 536056002518 DPS ferroxidase diiron center [ion binding]; other site 536056002519 ion pore; other site 536056002520 threonine and homoserine efflux system; Provisional; Region: PRK10532 536056002521 EamA-like transporter family; Region: EamA; pfam00892 536056002522 outer membrane protein X; Provisional; Region: ompX; PRK09408 536056002523 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 536056002524 Sulfatase; Region: Sulfatase; pfam00884 536056002525 manganese transport regulator MntR; Provisional; Region: PRK11050 536056002526 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 536056002527 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 536056002528 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 536056002529 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 536056002530 transmembrane helices; other site 536056002531 L,D-transpeptidase; Provisional; Region: PRK10260 536056002532 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 536056002533 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 536056002534 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536056002535 Walker A/P-loop; other site 536056002536 ATP binding site [chemical binding]; other site 536056002537 Q-loop/lid; other site 536056002538 ABC transporter signature motif; other site 536056002539 Walker B; other site 536056002540 D-loop; other site 536056002541 H-loop/switch region; other site 536056002542 ABC transporter; Region: ABC_tran_2; pfam12848 536056002543 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 536056002544 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 536056002545 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 536056002546 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536056002547 active site 536056002548 motif I; other site 536056002549 motif II; other site 536056002550 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536056002551 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 536056002552 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 536056002553 dimer interface [polypeptide binding]; other site 536056002554 active site 536056002555 glycine loop; other site 536056002556 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 536056002557 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 536056002558 active site 536056002559 intersubunit interactions; other site 536056002560 catalytic residue [active] 536056002561 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 536056002562 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 536056002563 ATP binding site [chemical binding]; other site 536056002564 substrate interface [chemical binding]; other site 536056002565 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 536056002566 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 536056002567 dimer interface [polypeptide binding]; other site 536056002568 putative functional site; other site 536056002569 putative MPT binding site; other site 536056002570 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 536056002571 catalytic nucleophile [active] 536056002572 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 536056002573 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536056002574 Walker A/P-loop; other site 536056002575 ATP binding site [chemical binding]; other site 536056002576 Q-loop/lid; other site 536056002577 ABC transporter signature motif; other site 536056002578 Walker B; other site 536056002579 D-loop; other site 536056002580 H-loop/switch region; other site 536056002581 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 536056002582 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536056002583 Walker A/P-loop; other site 536056002584 ATP binding site [chemical binding]; other site 536056002585 Q-loop/lid; other site 536056002586 ABC transporter signature motif; other site 536056002587 Walker B; other site 536056002588 D-loop; other site 536056002589 H-loop/switch region; other site 536056002590 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 536056002591 'function: ABC-type dipeptide transport system, periplasmic component; putative peptide transporter subunit:periplasmic-binding component of ABC superfamily, frameshift due to single base deletion' 536056002592 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 536056002593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056002594 dimer interface [polypeptide binding]; other site 536056002595 conserved gate region; other site 536056002596 putative PBP binding loops; other site 536056002597 ABC-ATPase subunit interface; other site 536056002598 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 536056002599 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 536056002600 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056002601 dimer interface [polypeptide binding]; other site 536056002602 conserved gate region; other site 536056002603 putative PBP binding loops; other site 536056002604 ABC-ATPase subunit interface; other site 536056002605 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 536056002606 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 536056002607 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 536056002608 metal binding site [ion binding]; metal-binding site 536056002609 active site 536056002610 I-site; other site 536056002611 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 536056002612 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 536056002613 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 536056002614 FeS/SAM binding site; other site 536056002615 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 536056002616 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 536056002617 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 536056002618 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 536056002619 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 536056002620 putative C-terminal domain interface [polypeptide binding]; other site 536056002621 putative GSH binding site (G-site) [chemical binding]; other site 536056002622 putative dimer interface [polypeptide binding]; other site 536056002623 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 536056002624 N-terminal domain interface [polypeptide binding]; other site 536056002625 dimer interface [polypeptide binding]; other site 536056002626 substrate binding pocket (H-site) [chemical binding]; other site 536056002627 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 536056002628 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 536056002629 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 536056002630 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 536056002631 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 536056002632 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 536056002633 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 536056002634 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 536056002635 active site 536056002636 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 536056002637 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056002638 putative substrate translocation pore; other site 536056002639 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 536056002640 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536056002641 active site 536056002642 motif I; other site 536056002643 motif II; other site 536056002644 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536056002645 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 536056002646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056002647 putative substrate translocation pore; other site 536056002648 Major Facilitator Superfamily; Region: MFS_1; pfam07690 536056002649 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 536056002650 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536056002651 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 536056002652 putative transporter; Provisional; Region: PRK04972 536056002653 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 536056002654 TrkA-C domain; Region: TrkA_C; pfam02080 536056002655 TrkA-C domain; Region: TrkA_C; pfam02080 536056002656 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 536056002657 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 536056002658 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 536056002659 GSH binding site [chemical binding]; other site 536056002660 catalytic residues [active] 536056002661 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 536056002662 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 536056002663 dimer interface [polypeptide binding]; other site 536056002664 FMN binding site [chemical binding]; other site 536056002665 NADPH bind site [chemical binding]; other site 536056002666 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 536056002667 RimK-like ATP-grasp domain; Region: RimK; pfam08443 536056002668 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 536056002669 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 536056002670 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 536056002671 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 536056002672 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536056002673 Walker A/P-loop; other site 536056002674 ATP binding site [chemical binding]; other site 536056002675 Q-loop/lid; other site 536056002676 ABC transporter signature motif; other site 536056002677 Walker B; other site 536056002678 D-loop; other site 536056002679 H-loop/switch region; other site 536056002680 TOBE domain; Region: TOBE_2; pfam08402 536056002681 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 536056002682 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056002683 dimer interface [polypeptide binding]; other site 536056002684 conserved gate region; other site 536056002685 putative PBP binding loops; other site 536056002686 ABC-ATPase subunit interface; other site 536056002687 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 536056002688 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056002689 dimer interface [polypeptide binding]; other site 536056002690 conserved gate region; other site 536056002691 putative PBP binding loops; other site 536056002692 ABC-ATPase subunit interface; other site 536056002693 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 536056002694 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 536056002695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536056002696 S-adenosylmethionine binding site [chemical binding]; other site 536056002697 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 536056002698 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536056002699 substrate binding pocket [chemical binding]; other site 536056002700 membrane-bound complex binding site; other site 536056002701 hinge residues; other site 536056002702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056002703 dimer interface [polypeptide binding]; other site 536056002704 conserved gate region; other site 536056002705 putative PBP binding loops; other site 536056002706 ABC-ATPase subunit interface; other site 536056002707 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 536056002708 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056002709 dimer interface [polypeptide binding]; other site 536056002710 conserved gate region; other site 536056002711 putative PBP binding loops; other site 536056002712 ABC-ATPase subunit interface; other site 536056002713 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 536056002714 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536056002715 substrate binding pocket [chemical binding]; other site 536056002716 membrane-bound complex binding site; other site 536056002717 hinge residues; other site 536056002718 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 536056002719 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536056002720 Walker A/P-loop; other site 536056002721 ATP binding site [chemical binding]; other site 536056002722 Q-loop/lid; other site 536056002723 ABC transporter signature motif; other site 536056002724 Walker B; other site 536056002725 D-loop; other site 536056002726 H-loop/switch region; other site 536056002727 putative lipoprotein; Provisional; Region: PRK10533 536056002728 hypothetical protein; Provisional; Region: PRK02877 536056002729 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 536056002730 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 536056002731 amidase catalytic site [active] 536056002732 Zn binding residues [ion binding]; other site 536056002733 substrate binding site [chemical binding]; other site 536056002734 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 536056002735 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536056002736 NAD(P) binding site [chemical binding]; other site 536056002737 active site 536056002738 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 536056002739 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 536056002740 putative NAD(P) binding site [chemical binding]; other site 536056002741 putative active site [active] 536056002742 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 536056002743 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 536056002744 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 536056002745 tetramer interface [polypeptide binding]; other site 536056002746 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056002747 catalytic residue [active] 536056002748 pyruvate dehydrogenase; Provisional; Region: PRK09124 536056002749 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 536056002750 PYR/PP interface [polypeptide binding]; other site 536056002751 dimer interface [polypeptide binding]; other site 536056002752 tetramer interface [polypeptide binding]; other site 536056002753 TPP binding site [chemical binding]; other site 536056002754 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 536056002755 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 536056002756 TPP-binding site [chemical binding]; other site 536056002757 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 536056002758 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 536056002759 FAD binding pocket [chemical binding]; other site 536056002760 FAD binding motif [chemical binding]; other site 536056002761 phosphate binding motif [ion binding]; other site 536056002762 beta-alpha-beta structure motif; other site 536056002763 NAD binding pocket [chemical binding]; other site 536056002764 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 536056002765 catalytic loop [active] 536056002766 iron binding site [ion binding]; other site 536056002767 hybrid cluster protein; Provisional; Region: PRK05290 536056002768 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 536056002769 ACS interaction site; other site 536056002770 CODH interaction site; other site 536056002771 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 536056002772 hybrid metal cluster; other site 536056002773 Predicted membrane protein [Function unknown]; Region: COG2431 536056002774 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 536056002775 amphipathic channel; other site 536056002776 Asn-Pro-Ala signature motifs; other site 536056002777 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 536056002778 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 536056002779 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 536056002780 putative active site [active] 536056002781 putative metal-binding site [ion binding]; other site 536056002782 Protein of unknown function (DUF535); Region: DUF535; pfam04393 536056002783 macrolide transporter subunit MacA; Provisional; Region: PRK11578 536056002784 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 536056002785 HlyD family secretion protein; Region: HlyD_3; pfam13437 536056002786 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 536056002787 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 536056002788 Walker A/P-loop; other site 536056002789 ATP binding site [chemical binding]; other site 536056002790 Q-loop/lid; other site 536056002791 ABC transporter signature motif; other site 536056002792 Walker B; other site 536056002793 D-loop; other site 536056002794 H-loop/switch region; other site 536056002795 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 536056002796 FtsX-like permease family; Region: FtsX; pfam02687 536056002797 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 536056002798 DNA-binding site [nucleotide binding]; DNA binding site 536056002799 RNA-binding motif; other site 536056002800 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 536056002801 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 536056002802 Clp amino terminal domain; Region: Clp_N; pfam02861 536056002803 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536056002804 Walker A motif; other site 536056002805 ATP binding site [chemical binding]; other site 536056002806 Walker B motif; other site 536056002807 arginine finger; other site 536056002808 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536056002809 Walker A motif; other site 536056002810 ATP binding site [chemical binding]; other site 536056002811 Walker B motif; other site 536056002812 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 536056002813 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 536056002814 rRNA binding site [nucleotide binding]; other site 536056002815 predicted 30S ribosome binding site; other site 536056002816 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 536056002817 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 536056002818 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 536056002819 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 536056002820 Walker A/P-loop; other site 536056002821 ATP binding site [chemical binding]; other site 536056002822 Q-loop/lid; other site 536056002823 ABC transporter signature motif; other site 536056002824 Walker B; other site 536056002825 D-loop; other site 536056002826 H-loop/switch region; other site 536056002827 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 536056002828 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 536056002829 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536056002830 Walker A/P-loop; other site 536056002831 ATP binding site [chemical binding]; other site 536056002832 Q-loop/lid; other site 536056002833 ABC transporter signature motif; other site 536056002834 Walker B; other site 536056002835 D-loop; other site 536056002836 H-loop/switch region; other site 536056002837 thioredoxin reductase; Provisional; Region: PRK10262 536056002838 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 536056002839 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 536056002840 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 536056002841 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536056002842 putative DNA binding site [nucleotide binding]; other site 536056002843 putative Zn2+ binding site [ion binding]; other site 536056002844 AsnC family; Region: AsnC_trans_reg; pfam01037 536056002845 DNA translocase FtsK; Provisional; Region: PRK10263 536056002846 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 536056002847 DNA translocase FtsK; Provisional; Region: PRK10263 536056002848 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 536056002849 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 536056002850 periplasmic chaperone LolA; Region: lolA; TIGR00547 536056002851 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 536056002852 recombination factor protein RarA; Reviewed; Region: PRK13342 536056002853 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536056002854 Walker A motif; other site 536056002855 ATP binding site [chemical binding]; other site 536056002856 Walker B motif; other site 536056002857 arginine finger; other site 536056002858 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 536056002859 seryl-tRNA synthetase; Provisional; Region: PRK05431 536056002860 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 536056002861 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 536056002862 dimer interface [polypeptide binding]; other site 536056002863 active site 536056002864 motif 1; other site 536056002865 motif 2; other site 536056002866 motif 3; other site 536056002867 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 536056002868 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 536056002869 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 536056002870 putative [Fe4-S4] binding site [ion binding]; other site 536056002871 putative molybdopterin cofactor binding site [chemical binding]; other site 536056002872 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 536056002873 putative molybdopterin cofactor binding site; other site 536056002874 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 536056002875 4Fe-4S binding domain; Region: Fer4; pfam00037 536056002876 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 536056002877 Isochorismatase family; Region: Isochorismatase; pfam00857 536056002878 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 536056002879 catalytic triad [active] 536056002880 dimer interface [polypeptide binding]; other site 536056002881 conserved cis-peptide bond; other site 536056002882 putative MFS family transporter protein; Provisional; Region: PRK03633 536056002883 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056002884 putative substrate translocation pore; other site 536056002885 Amino acid permease; Region: AA_permease_2; pfam13520 536056002886 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536056002887 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056002888 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 536056002889 putative effector binding pocket; other site 536056002890 putative dimerization interface [polypeptide binding]; other site 536056002891 hypothetical protein; Provisional; Region: PRK09739 536056002892 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 536056002893 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 536056002894 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 536056002895 FeS/SAM binding site; other site 536056002896 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 536056002897 Pyruvate formate lyase 1; Region: PFL1; cd01678 536056002898 coenzyme A binding site [chemical binding]; other site 536056002899 active site 536056002900 catalytic residues [active] 536056002901 glycine loop; other site 536056002902 formate transporter; Provisional; Region: PRK10805 536056002903 uncharacterized domain; Region: TIGR00702 536056002904 YcaO-like family; Region: YcaO; pfam02624 536056002905 Predicted membrane protein [Function unknown]; Region: COG2323 536056002906 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 536056002907 homodimer interface [polypeptide binding]; other site 536056002908 substrate-cofactor binding pocket; other site 536056002909 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056002910 catalytic residue [active] 536056002911 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 536056002912 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 536056002913 hinge; other site 536056002914 active site 536056002915 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 536056002916 cytidylate kinase; Provisional; Region: cmk; PRK00023 536056002917 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 536056002918 CMP-binding site; other site 536056002919 The sites determining sugar specificity; other site 536056002920 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 536056002921 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 536056002922 RNA binding site [nucleotide binding]; other site 536056002923 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 536056002924 RNA binding site [nucleotide binding]; other site 536056002925 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 536056002926 RNA binding site [nucleotide binding]; other site 536056002927 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 536056002928 RNA binding site [nucleotide binding]; other site 536056002929 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 536056002930 RNA binding site [nucleotide binding]; other site 536056002931 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 536056002932 IHF dimer interface [polypeptide binding]; other site 536056002933 IHF - DNA interface [nucleotide binding]; other site 536056002934 ComEC family competence protein; Provisional; Region: PRK11539 536056002935 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 536056002936 ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360 536056002937 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 536056002938 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 536056002939 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 536056002940 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 536056002941 Walker A/P-loop; other site 536056002942 ATP binding site [chemical binding]; other site 536056002943 Q-loop/lid; other site 536056002944 ABC transporter signature motif; other site 536056002945 Walker B; other site 536056002946 D-loop; other site 536056002947 H-loop/switch region; other site 536056002948 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 536056002949 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 536056002950 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 536056002951 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 536056002952 hypothetical protein; Provisional; Region: PRK11827 536056002953 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 536056002954 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 536056002955 Ligand binding site; other site 536056002956 oligomer interface; other site 536056002957 hypothetical protein; Provisional; Region: PRK10593 536056002958 Uncharacterized conserved protein [Function unknown]; Region: COG1434 536056002959 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 536056002960 putative active site [active] 536056002961 Methyltransferase domain; Region: Methyltransf_31; pfam13847 536056002962 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536056002963 S-adenosylmethionine binding site [chemical binding]; other site 536056002964 condesin subunit F; Provisional; Region: PRK05260 536056002965 condesin subunit E; Provisional; Region: PRK05256 536056002966 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 536056002967 MukB N-terminal; Region: MukB; pfam04310 536056002968 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 536056002969 murein L,D-transpeptidase; Provisional; Region: PRK10594 536056002970 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 536056002971 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 536056002972 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 536056002973 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 536056002974 Peptidase M15; Region: Peptidase_M15_3; cl01194 536056002975 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 536056002976 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 536056002977 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 536056002978 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056002979 homodimer interface [polypeptide binding]; other site 536056002980 catalytic residue [active] 536056002981 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 536056002982 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 536056002983 trimer interface [polypeptide binding]; other site 536056002984 eyelet of channel; other site 536056002985 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 536056002986 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 536056002987 putative dimer interface [polypeptide binding]; other site 536056002988 putative anticodon binding site; other site 536056002989 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 536056002990 homodimer interface [polypeptide binding]; other site 536056002991 motif 1; other site 536056002992 motif 2; other site 536056002993 active site 536056002994 motif 3; other site 536056002995 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 536056002996 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 536056002997 active site 536056002998 aminopeptidase N; Provisional; Region: pepN; PRK14015 536056002999 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 536056003000 active site 536056003001 Zn binding site [ion binding]; other site 536056003002 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 536056003003 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 536056003004 Walker A/P-loop; other site 536056003005 ATP binding site [chemical binding]; other site 536056003006 Q-loop/lid; other site 536056003007 ABC transporter signature motif; other site 536056003008 Walker B; other site 536056003009 D-loop; other site 536056003010 H-loop/switch region; other site 536056003011 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 536056003012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056003013 dimer interface [polypeptide binding]; other site 536056003014 conserved gate region; other site 536056003015 putative PBP binding loops; other site 536056003016 ABC-ATPase subunit interface; other site 536056003017 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 536056003018 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 536056003019 active site 536056003020 dimer interface [polypeptide binding]; other site 536056003021 non-prolyl cis peptide bond; other site 536056003022 insertion regions; other site 536056003023 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536056003024 substrate binding pocket [chemical binding]; other site 536056003025 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 536056003026 membrane-bound complex binding site; other site 536056003027 hinge residues; other site 536056003028 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 536056003029 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 536056003030 Fimbrial protein; Region: Fimbrial; cl01416 536056003031 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 536056003032 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 536056003033 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 536056003034 outer membrane usher protein; Provisional; Region: PRK15193 536056003035 PapC N-terminal domain; Region: PapC_N; pfam13954 536056003036 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 536056003037 PapC C-terminal domain; Region: PapC_C; pfam13953 536056003038 Fimbrial protein; Region: Fimbrial; cl01416 536056003039 Fimbrial protein; Region: Fimbrial; cl01416 536056003040 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 536056003041 putativi pili assembly chaperone; Provisional; Region: PRK11385 536056003042 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 536056003043 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 536056003044 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 536056003045 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 536056003046 quinone interaction residues [chemical binding]; other site 536056003047 active site 536056003048 catalytic residues [active] 536056003049 FMN binding site [chemical binding]; other site 536056003050 substrate binding site [chemical binding]; other site 536056003051 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 536056003052 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 536056003053 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 536056003054 MOSC domain; Region: MOSC; pfam03473 536056003055 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 536056003056 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 536056003057 catalytic loop [active] 536056003058 iron binding site [ion binding]; other site 536056003059 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 536056003060 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 536056003061 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 536056003062 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536056003063 S-adenosylmethionine binding site [chemical binding]; other site 536056003064 ABC transporter ATPase component; Reviewed; Region: PRK11147 536056003065 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536056003066 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536056003067 Walker A/P-loop; other site 536056003068 Walker A/P-loop; other site 536056003069 ATP binding site [chemical binding]; other site 536056003070 ATP binding site [chemical binding]; other site 536056003071 Q-loop/lid; other site 536056003072 Q-loop/lid; other site 536056003073 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 536056003074 ABC transporter signature motif; other site 536056003075 Walker B; other site 536056003076 D-loop; other site 536056003077 ABC transporter; Region: ABC_tran_2; pfam12848 536056003078 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 536056003079 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 536056003080 Paraquat-inducible protein A; Region: PqiA; pfam04403 536056003081 Paraquat-inducible protein A; Region: PqiA; pfam04403 536056003082 paraquat-inducible protein B; Provisional; Region: PRK10807 536056003083 mce related protein; Region: MCE; pfam02470 536056003084 mce related protein; Region: MCE; pfam02470 536056003085 mce related protein; Region: MCE; pfam02470 536056003086 DASH complex subunit Duo1; Region: DASH_Duo1; pfam08651 536056003087 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 536056003088 Protein of unknown function (DUF330); Region: DUF330; pfam03886 536056003089 ribosome modulation factor; Provisional; Region: PRK14563 536056003090 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 536056003091 active site 1 [active] 536056003092 dimer interface [polypeptide binding]; other site 536056003093 active site 2 [active] 536056003094 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 536056003095 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 536056003096 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 536056003097 outer membrane protein A; Reviewed; Region: PRK10808 536056003098 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 536056003099 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 536056003100 ligand binding site [chemical binding]; other site 536056003101 cell division inhibitor SulA; Region: sula; TIGR00623 536056003102 cell division inhibitor SulA; Region: sula; TIGR00623 536056003103 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 536056003104 TfoX C-terminal domain; Region: TfoX_C; pfam04994 536056003105 TIGR01666 family membrane protein; Region: YCCS 536056003106 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 536056003107 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 536056003108 Predicted membrane protein [Function unknown]; Region: COG3304 536056003109 Domain of unknown function (DUF307); Region: DUF307; pfam03733 536056003110 Domain of unknown function (DUF307); Region: DUF307; pfam03733 536056003111 DNA helicase IV; Provisional; Region: helD; PRK11054 536056003112 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 536056003113 Part of AAA domain; Region: AAA_19; pfam13245 536056003114 Family description; Region: UvrD_C_2; pfam13538 536056003115 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 536056003116 active site 536056003117 dimer interfaces [polypeptide binding]; other site 536056003118 catalytic residues [active] 536056003119 'conserved protein, pseudogene due to insertion' 536056003120 IS2 repressor TnpA; Reviewed; Region: PRK09413 536056003121 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 536056003122 IS2 transposase TnpB; Reviewed; Region: PRK09409 536056003123 HTH-like domain; Region: HTH_21; pfam13276 536056003124 Integrase core domain; Region: rve; pfam00665 536056003125 Integrase core domain; Region: rve_3; pfam13683 536056003126 'conserved protein, pseudogene due to insertion' 536056003127 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 536056003128 heat shock protein HspQ; Provisional; Region: PRK14129 536056003129 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 536056003130 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 536056003131 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 536056003132 putative RNA binding site [nucleotide binding]; other site 536056003133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536056003134 S-adenosylmethionine binding site [chemical binding]; other site 536056003135 Acylphosphatase; Region: Acylphosphatase; cl00551 536056003136 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 536056003137 sulfur transfer protein TusE; Provisional; Region: PRK11508 536056003138 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 536056003139 YccA-like proteins; Region: YccA_like; cd10433 536056003140 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 536056003141 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 536056003142 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 536056003143 hydrogenase 1 large subunit; Provisional; Region: PRK10170 536056003144 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 536056003145 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 536056003146 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 536056003147 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 536056003148 putative substrate-binding site; other site 536056003149 nickel binding site [ion binding]; other site 536056003150 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 536056003151 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 536056003152 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 536056003153 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 536056003154 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 536056003155 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 536056003156 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 536056003157 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 536056003158 catalytic core [active] 536056003159 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 536056003160 cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841 536056003161 Chain length determinant protein; Region: Wzz; pfam02706 536056003162 Chain length determinant protein; Region: Wzz; cl15801 536056003163 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 536056003164 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 536056003165 Nucleotide binding site [chemical binding]; other site 536056003166 Low molecular weight phosphatase family; Region: LMWPc; cd00115 536056003167 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 536056003168 active site 536056003169 polysaccharide export protein Wza; Provisional; Region: PRK15078 536056003170 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 536056003171 SLBB domain; Region: SLBB; pfam10531 536056003172 SLBB domain; Region: SLBB; pfam10531 536056003173 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 536056003174 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 536056003175 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 536056003176 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 536056003177 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 536056003178 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 536056003179 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 536056003180 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 536056003181 DNA-binding site [nucleotide binding]; DNA binding site 536056003182 RNA-binding motif; other site 536056003183 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 536056003184 DNA-binding site [nucleotide binding]; DNA binding site 536056003185 RNA-binding motif; other site 536056003186 cold shock gene; Provisional; Region: PRK09891 536056003187 GnsA/GnsB family; Region: GnsAB; pfam08178 536056003188 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 536056003189 4Fe-4S binding domain; Region: Fer4_5; pfam12801 536056003190 4Fe-4S binding domain; Region: Fer4_5; pfam12801 536056003191 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 536056003192 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 536056003193 HAMP domain; Region: HAMP; pfam00672 536056003194 dimerization interface [polypeptide binding]; other site 536056003195 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536056003196 dimer interface [polypeptide binding]; other site 536056003197 phosphorylation site [posttranslational modification] 536056003198 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536056003199 ATP binding site [chemical binding]; other site 536056003200 Mg2+ binding site [ion binding]; other site 536056003201 G-X-G motif; other site 536056003202 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536056003203 active site 536056003204 phosphorylation site [posttranslational modification] 536056003205 intermolecular recognition site; other site 536056003206 dimerization interface [polypeptide binding]; other site 536056003207 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 536056003208 putative binding surface; other site 536056003209 active site 536056003210 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 536056003211 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 536056003212 putative ligand binding site [chemical binding]; other site 536056003213 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 536056003214 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536056003215 active site 536056003216 phosphorylation site [posttranslational modification] 536056003217 intermolecular recognition site; other site 536056003218 dimerization interface [polypeptide binding]; other site 536056003219 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 536056003220 DNA binding site [nucleotide binding] 536056003221 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 536056003222 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 536056003223 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 536056003224 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 536056003225 molybdopterin cofactor binding site [chemical binding]; other site 536056003226 substrate binding site [chemical binding]; other site 536056003227 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 536056003228 molybdopterin cofactor binding site; other site 536056003229 chaperone protein TorD; Validated; Region: torD; PRK04976 536056003230 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 536056003231 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 536056003232 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 536056003233 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 536056003234 HSP70 interaction site [polypeptide binding]; other site 536056003235 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 536056003236 substrate binding site [polypeptide binding]; other site 536056003237 dimer interface [polypeptide binding]; other site 536056003238 hypothetical protein; Provisional; Region: PRK09784 536056003239 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 536056003240 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 536056003241 catalytic core [active] 536056003242 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 536056003243 hypothetical protein; Provisional; Region: PRK10174 536056003244 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 536056003245 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 536056003246 General stress protein [General function prediction only]; Region: GsiB; COG3729 536056003247 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 536056003248 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 536056003249 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 536056003250 putative FMN binding site [chemical binding]; other site 536056003251 pyrimidine utilization protein D; Region: RutD; TIGR03611 536056003252 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 536056003253 homotrimer interaction site [polypeptide binding]; other site 536056003254 putative active site [active] 536056003255 Isochorismatase family; Region: Isochorismatase; pfam00857 536056003256 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 536056003257 catalytic triad [active] 536056003258 conserved cis-peptide bond; other site 536056003259 pyrimidine utilization protein A; Region: RutA; TIGR03612 536056003260 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 536056003261 active site 536056003262 dimer interface [polypeptide binding]; other site 536056003263 non-prolyl cis peptide bond; other site 536056003264 insertion regions; other site 536056003265 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 536056003266 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 536056003267 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536056003268 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 536056003269 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 536056003270 Predicted transcriptional regulator [Transcription]; Region: COG3905 536056003271 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 536056003272 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 536056003273 Glutamate binding site [chemical binding]; other site 536056003274 NAD binding site [chemical binding]; other site 536056003275 catalytic residues [active] 536056003276 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 536056003277 Na binding site [ion binding]; other site 536056003278 Iron permease FTR1 family; Region: FTR1; cl00475 536056003279 Iron permease FTR1 family; Region: FTR1; cl00475 536056003280 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 536056003281 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 536056003282 Imelysin; Region: Peptidase_M75; pfam09375 536056003283 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 536056003284 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 536056003285 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 536056003286 hypothetical protein; Provisional; Region: PRK10536 536056003287 putative PGA biosynthesis protein; Provisional; Region: pgaD; PRK14585 536056003288 N-glycosyltransferase; Provisional; Region: PRK11204 536056003289 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 536056003290 DXD motif; other site 536056003291 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 536056003292 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 536056003293 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 536056003294 putative active site [active] 536056003295 putative metal binding site [ion binding]; other site 536056003296 'predicted outer membrane protein, missing start codon due to deletion' 536056003297 Transposase domain (DUF772); Region: DUF772; pfam05598 536056003298 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 536056003299 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 536056003300 Fimbrial protein; Region: Fimbrial; cl01416 536056003301 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 536056003302 putative ADP-ribose binding site [chemical binding]; other site 536056003303 putative active site [active] 536056003304 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 536056003305 PLD-like domain; Region: PLDc_2; pfam13091 536056003306 putative active site [active] 536056003307 catalytic site [active] 536056003308 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 536056003309 PLD-like domain; Region: PLDc_2; pfam13091 536056003310 putative active site [active] 536056003311 catalytic site [active] 536056003312 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 536056003313 Acyltransferase family; Region: Acyl_transf_3; pfam01757 536056003314 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 536056003315 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 536056003316 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 536056003317 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 536056003318 Ligand binding site; other site 536056003319 DXD motif; other site 536056003320 lipoprotein; Provisional; Region: PRK10175 536056003321 secY/secA suppressor protein; Provisional; Region: PRK11467 536056003322 drug efflux system protein MdtG; Provisional; Region: PRK09874 536056003323 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056003324 putative substrate translocation pore; other site 536056003325 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 536056003326 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 536056003327 putative acyl-acceptor binding pocket; other site 536056003328 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 536056003329 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 536056003330 active site residue [active] 536056003331 hypothetical protein; Provisional; Region: PRK03757 536056003332 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 536056003333 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 536056003334 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 536056003335 hydroxyglutarate oxidase; Provisional; Region: PRK11728 536056003336 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 536056003337 DNA damage-inducible protein I; Provisional; Region: PRK10597 536056003338 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 536056003339 active site 536056003340 substrate binding pocket [chemical binding]; other site 536056003341 dimer interface [polypeptide binding]; other site 536056003342 lipoprotein; Provisional; Region: PRK10598 536056003343 glutaredoxin 2; Provisional; Region: PRK10387 536056003344 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 536056003345 C-terminal domain interface [polypeptide binding]; other site 536056003346 GSH binding site (G-site) [chemical binding]; other site 536056003347 catalytic residues [active] 536056003348 putative dimer interface [polypeptide binding]; other site 536056003349 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 536056003350 N-terminal domain interface [polypeptide binding]; other site 536056003351 multidrug resistance protein MdtH; Provisional; Region: PRK11646 536056003352 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056003353 putative substrate translocation pore; other site 536056003354 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 536056003355 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 536056003356 hypothetical protein; Provisional; Region: PRK11239 536056003357 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 536056003358 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 536056003359 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 536056003360 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 536056003361 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 536056003362 MviN-like protein; Region: MVIN; pfam03023 536056003363 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 536056003364 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 536056003365 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 536056003366 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 536056003367 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 536056003368 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 536056003369 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 536056003370 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 536056003371 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 536056003372 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 536056003373 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 536056003374 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 536056003375 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 536056003376 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 536056003377 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 536056003378 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 536056003379 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 536056003380 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 536056003381 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 536056003382 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 536056003383 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 536056003384 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 536056003385 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 536056003386 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 536056003387 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 536056003388 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 536056003389 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 536056003390 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 536056003391 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 536056003392 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 536056003393 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 536056003394 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 536056003395 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 536056003396 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 536056003397 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 536056003398 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 536056003399 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 536056003400 homodimer interface [polypeptide binding]; other site 536056003401 oligonucleotide binding site [chemical binding]; other site 536056003402 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 536056003403 Protein of unknown function (DUF2655); Region: DUF2655; pfam10848 536056003404 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 536056003405 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 536056003406 RNA binding surface [nucleotide binding]; other site 536056003407 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 536056003408 active site 536056003409 Maf-like protein; Region: Maf; pfam02545 536056003410 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 536056003411 active site 536056003412 dimer interface [polypeptide binding]; other site 536056003413 hypothetical protein; Provisional; Region: PRK11193 536056003414 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 536056003415 putative phosphate acyltransferase; Provisional; Region: PRK05331 536056003416 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 536056003417 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 536056003418 dimer interface [polypeptide binding]; other site 536056003419 active site 536056003420 CoA binding pocket [chemical binding]; other site 536056003421 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 536056003422 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 536056003423 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 536056003424 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 536056003425 NAD(P) binding site [chemical binding]; other site 536056003426 homotetramer interface [polypeptide binding]; other site 536056003427 homodimer interface [polypeptide binding]; other site 536056003428 active site 536056003429 acyl carrier protein; Provisional; Region: acpP; PRK00982 536056003430 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 536056003431 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 536056003432 dimer interface [polypeptide binding]; other site 536056003433 active site 536056003434 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 536056003435 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 536056003436 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056003437 catalytic residue [active] 536056003438 conserved hypothetical protein, YceG family; Region: TIGR00247 536056003439 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 536056003440 dimerization interface [polypeptide binding]; other site 536056003441 thymidylate kinase; Validated; Region: tmk; PRK00698 536056003442 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 536056003443 TMP-binding site; other site 536056003444 ATP-binding site [chemical binding]; other site 536056003445 DNA polymerase III subunit delta'; Validated; Region: PRK07993 536056003446 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 536056003447 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 536056003448 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 536056003449 active site 536056003450 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 536056003451 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 536056003452 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 536056003453 active site turn [active] 536056003454 phosphorylation site [posttranslational modification] 536056003455 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 536056003456 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 536056003457 N-terminal plug; other site 536056003458 ligand-binding site [chemical binding]; other site 536056003459 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 536056003460 nucleotide binding site/active site [active] 536056003461 HIT family signature motif; other site 536056003462 catalytic residue [active] 536056003463 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 536056003464 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 536056003465 putative dimer interface [polypeptide binding]; other site 536056003466 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 536056003467 thiamine kinase; Region: ycfN_thiK; TIGR02721 536056003468 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 536056003469 active site 536056003470 substrate binding site [chemical binding]; other site 536056003471 ATP binding site [chemical binding]; other site 536056003472 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 536056003473 beta-hexosaminidase; Provisional; Region: PRK05337 536056003474 hypothetical protein; Provisional; Region: PRK04940 536056003475 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 536056003476 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 536056003477 hypothetical protein; Provisional; Region: PRK11280 536056003478 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 536056003479 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536056003480 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 536056003481 L,D-transpeptidase; Provisional; Region: PRK10260 536056003482 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 536056003483 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 536056003484 transcription-repair coupling factor; Provisional; Region: PRK10689 536056003485 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 536056003486 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 536056003487 ATP binding site [chemical binding]; other site 536056003488 putative Mg++ binding site [ion binding]; other site 536056003489 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 536056003490 nucleotide binding region [chemical binding]; other site 536056003491 ATP-binding site [chemical binding]; other site 536056003492 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 536056003493 Predicted membrane protein [Function unknown]; Region: COG4763 536056003494 Acyltransferase family; Region: Acyl_transf_3; pfam01757 536056003495 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 536056003496 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 536056003497 FtsX-like permease family; Region: FtsX; pfam02687 536056003498 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 536056003499 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 536056003500 Walker A/P-loop; other site 536056003501 ATP binding site [chemical binding]; other site 536056003502 Q-loop/lid; other site 536056003503 ABC transporter signature motif; other site 536056003504 Walker B; other site 536056003505 D-loop; other site 536056003506 H-loop/switch region; other site 536056003507 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 536056003508 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 536056003509 FtsX-like permease family; Region: FtsX; pfam02687 536056003510 fructokinase; Reviewed; Region: PRK09557 536056003511 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 536056003512 nucleotide binding site [chemical binding]; other site 536056003513 NAD-dependent deacetylase; Provisional; Region: PRK00481 536056003514 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 536056003515 NAD+ binding site [chemical binding]; other site 536056003516 substrate binding site [chemical binding]; other site 536056003517 Zn binding site [ion binding]; other site 536056003518 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 536056003519 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 536056003520 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 536056003521 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 536056003522 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 536056003523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056003524 dimer interface [polypeptide binding]; other site 536056003525 conserved gate region; other site 536056003526 putative PBP binding loops; other site 536056003527 ABC-ATPase subunit interface; other site 536056003528 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 536056003529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056003530 dimer interface [polypeptide binding]; other site 536056003531 conserved gate region; other site 536056003532 putative PBP binding loops; other site 536056003533 ABC-ATPase subunit interface; other site 536056003534 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 536056003535 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536056003536 Walker A/P-loop; other site 536056003537 ATP binding site [chemical binding]; other site 536056003538 Q-loop/lid; other site 536056003539 ABC transporter signature motif; other site 536056003540 Walker B; other site 536056003541 D-loop; other site 536056003542 H-loop/switch region; other site 536056003543 TOBE domain; Region: TOBE_2; pfam08402 536056003544 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 536056003545 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536056003546 Walker A/P-loop; other site 536056003547 ATP binding site [chemical binding]; other site 536056003548 Q-loop/lid; other site 536056003549 ABC transporter signature motif; other site 536056003550 Walker B; other site 536056003551 D-loop; other site 536056003552 H-loop/switch region; other site 536056003553 TOBE domain; Region: TOBE_2; pfam08402 536056003554 'peptidase T, new stop codon appreared due to single base deletion' 536056003555 Uncharacterized conserved protein [Function unknown]; Region: COG2850 536056003556 Cupin-like domain; Region: Cupin_8; pfam13621 536056003557 sensor protein PhoQ; Provisional; Region: PRK10815 536056003558 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 536056003559 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 536056003560 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 536056003561 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536056003562 ATP binding site [chemical binding]; other site 536056003563 Mg2+ binding site [ion binding]; other site 536056003564 G-X-G motif; other site 536056003565 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 536056003566 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536056003567 active site 536056003568 phosphorylation site [posttranslational modification] 536056003569 intermolecular recognition site; other site 536056003570 dimerization interface [polypeptide binding]; other site 536056003571 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 536056003572 DNA binding site [nucleotide binding] 536056003573 adenylosuccinate lyase; Provisional; Region: PRK09285 536056003574 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 536056003575 tetramer interface [polypeptide binding]; other site 536056003576 active site 536056003577 putative lysogenization regulator; Reviewed; Region: PRK00218 536056003578 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 536056003579 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 536056003580 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 536056003581 nudix motif; other site 536056003582 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 536056003583 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 536056003584 probable active site [active] 536056003585 isocitrate dehydrogenase; Validated; Region: PRK07362 536056003586 isocitrate dehydrogenase; Reviewed; Region: PRK07006 536056003587 Methyltransferase domain; Region: Methyltransf_23; pfam13489 536056003588 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536056003589 S-adenosylmethionine binding site [chemical binding]; other site 536056003590 phage exclusion protein Lit; Provisional; Region: PRK09672 536056003591 Peptidase U49; Region: Peptidase_U49; pfam10463 536056003592 Transposase; Region: HTH_Tnp_1; cl17663 536056003593 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 536056003594 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 536056003595 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 536056003596 Excisionase-like protein; Region: Exc; pfam07825 536056003597 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 536056003598 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 536056003599 Catalytic site [active] 536056003600 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536056003601 DNA-binding site [nucleotide binding]; DNA binding site 536056003602 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 536056003603 Phage-related protein [Function unknown]; Region: COG4695 536056003604 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 536056003605 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3778 536056003606 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 536056003607 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 536056003608 Phage Tail Collar Domain; Region: Collar; pfam07484 536056003609 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 536056003610 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 536056003611 catalytic residues [active] 536056003612 catalytic nucleophile [active] 536056003613 Presynaptic Site I dimer interface [polypeptide binding]; other site 536056003614 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 536056003615 Synaptic Flat tetramer interface [polypeptide binding]; other site 536056003616 Synaptic Site I dimer interface [polypeptide binding]; other site 536056003617 DNA binding site [nucleotide binding] 536056003618 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 536056003619 DNA-binding interface [nucleotide binding]; DNA binding site 536056003620 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 536056003621 active site 536056003622 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 536056003623 anti-adapter protein IraM; Provisional; Region: PRK09919 536056003624 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 536056003625 transcriptional regulator MirA; Provisional; Region: PRK15043 536056003626 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 536056003627 DNA binding residues [nucleotide binding] 536056003628 Sensors of blue-light using FAD; Region: BLUF; smart01034 536056003629 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 536056003630 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 536056003631 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 536056003632 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 536056003633 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 536056003634 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 536056003635 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 536056003636 Autotransporter beta-domain; Region: Autotransporter; pfam03797 536056003637 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 536056003638 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 536056003639 cell division inhibitor MinD; Provisional; Region: PRK10818 536056003640 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 536056003641 Switch I; other site 536056003642 Switch II; other site 536056003643 septum formation inhibitor; Reviewed; Region: minC; PRK03511 536056003644 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 536056003645 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 536056003646 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 536056003647 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 536056003648 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 536056003649 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 536056003650 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 536056003651 hypothetical protein; Provisional; Region: PRK10691 536056003652 hypothetical protein; Provisional; Region: PRK05170 536056003653 hemolysin E; Provisional; Region: hlyE; PRK11376 536056003654 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 536056003655 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 536056003656 Catalytic site [active] 536056003657 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 536056003658 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 536056003659 active site 536056003660 DNA binding site [nucleotide binding] 536056003661 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 536056003662 disulfide bond formation protein B; Provisional; Region: PRK01749 536056003663 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 536056003664 transmembrane helices; other site 536056003665 fatty acid metabolism regulator; Provisional; Region: PRK04984 536056003666 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536056003667 DNA-binding site [nucleotide binding]; DNA binding site 536056003668 FadR C-terminal domain; Region: FadR_C; pfam07840 536056003669 SpoVR family protein; Provisional; Region: PRK11767 536056003670 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 536056003671 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 536056003672 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 536056003673 alanine racemase; Reviewed; Region: dadX; PRK03646 536056003674 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 536056003675 active site 536056003676 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 536056003677 substrate binding site [chemical binding]; other site 536056003678 catalytic residues [active] 536056003679 dimer interface [polypeptide binding]; other site 536056003680 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 536056003681 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 536056003682 TrkA-C domain; Region: TrkA_C; pfam02080 536056003683 Transporter associated domain; Region: CorC_HlyC; smart01091 536056003684 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 536056003685 dimer interface [polypeptide binding]; other site 536056003686 catalytic triad [active] 536056003687 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 536056003688 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 536056003689 N-acetyl-D-glucosamine binding site [chemical binding]; other site 536056003690 catalytic residue [active] 536056003691 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 536056003692 Flagellar regulator YcgR; Region: YcgR; pfam07317 536056003693 PilZ domain; Region: PilZ; pfam07238 536056003694 hypothetical protein; Provisional; Region: PRK10457 536056003695 trehalase; Provisional; Region: treA; PRK13271 536056003696 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 536056003697 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 536056003698 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 536056003699 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 536056003700 dimerization domain swap beta strand [polypeptide binding]; other site 536056003701 regulatory protein interface [polypeptide binding]; other site 536056003702 active site 536056003703 regulatory phosphorylation site [posttranslational modification]; other site 536056003704 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 536056003705 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 536056003706 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 536056003707 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 536056003708 Dak1 domain; Region: Dak1; pfam02733 536056003709 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 536056003710 PAS domain; Region: PAS; smart00091 536056003711 putative active site [active] 536056003712 heme pocket [chemical binding]; other site 536056003713 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536056003714 Walker A motif; other site 536056003715 ATP binding site [chemical binding]; other site 536056003716 Walker B motif; other site 536056003717 arginine finger; other site 536056003718 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 536056003719 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 536056003720 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 536056003721 Autotransporter beta-domain; Region: Autotransporter; pfam03797 536056003722 GTP-binding protein YchF; Reviewed; Region: PRK09601 536056003723 YchF GTPase; Region: YchF; cd01900 536056003724 G1 box; other site 536056003725 GTP/Mg2+ binding site [chemical binding]; other site 536056003726 Switch I region; other site 536056003727 G2 box; other site 536056003728 Switch II region; other site 536056003729 G3 box; other site 536056003730 G4 box; other site 536056003731 G5 box; other site 536056003732 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 536056003733 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 536056003734 putative active site [active] 536056003735 catalytic residue [active] 536056003736 hypothetical protein; Provisional; Region: PRK10692 536056003737 putative transporter; Provisional; Region: PRK11660 536056003738 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 536056003739 Sulfate transporter family; Region: Sulfate_transp; pfam00916 536056003740 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 536056003741 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 536056003742 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 536056003743 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 536056003744 active site 536056003745 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 536056003746 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 536056003747 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 536056003748 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 536056003749 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 536056003750 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 536056003751 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 536056003752 tRNA; other site 536056003753 putative tRNA binding site [nucleotide binding]; other site 536056003754 putative NADP binding site [chemical binding]; other site 536056003755 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 536056003756 peptide chain release factor 1; Validated; Region: prfA; PRK00591 536056003757 This domain is found in peptide chain release factors; Region: PCRF; smart00937 536056003758 RF-1 domain; Region: RF-1; pfam00472 536056003759 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 536056003760 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536056003761 hypothetical protein; Provisional; Region: PRK10278 536056003762 hypothetical protein; Provisional; Region: PRK10941 536056003763 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 536056003764 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 536056003765 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 536056003766 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 536056003767 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 536056003768 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 536056003769 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 536056003770 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 536056003771 cation transport regulator; Reviewed; Region: chaB; PRK09582 536056003772 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 536056003773 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 536056003774 putative active site pocket [active] 536056003775 dimerization interface [polypeptide binding]; other site 536056003776 putative catalytic residue [active] 536056003777 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 536056003778 putative invasin; Provisional; Region: PRK10177 536056003779 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 536056003780 transcriptional regulator NarL; Provisional; Region: PRK10651 536056003781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536056003782 active site 536056003783 phosphorylation site [posttranslational modification] 536056003784 intermolecular recognition site; other site 536056003785 dimerization interface [polypeptide binding]; other site 536056003786 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536056003787 DNA binding residues [nucleotide binding] 536056003788 dimerization interface [polypeptide binding]; other site 536056003789 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 536056003790 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 536056003791 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 536056003792 dimerization interface [polypeptide binding]; other site 536056003793 Histidine kinase; Region: HisKA_3; pfam07730 536056003794 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536056003795 ATP binding site [chemical binding]; other site 536056003796 Mg2+ binding site [ion binding]; other site 536056003797 G-X-G motif; other site 536056003798 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 536056003799 'function: Nitrate reductase alpha subunit; nitrate reductase 1, alpha subunit, a stop codon appeared' 536056003800 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 536056003801 4Fe-4S binding domain; Region: Fer4; cl02805 536056003802 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 536056003803 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 536056003804 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 536056003805 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 536056003806 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 536056003807 putative active site [active] 536056003808 putative substrate binding site [chemical binding]; other site 536056003809 putative cosubstrate binding site; other site 536056003810 catalytic site [active] 536056003811 SEC-C motif; Region: SEC-C; pfam02810 536056003812 hypothetical protein; Provisional; Region: PRK04233 536056003813 hypothetical protein; Provisional; Region: PRK10279 536056003814 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 536056003815 active site 536056003816 nucleophile elbow; other site 536056003817 'function: FOG: CheY-like receiver / regulator; Basic proteins - synthesis, modification; response regulator of RpoS, a stop codon appeared' 536056003818 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 536056003819 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 536056003820 active site 536056003821 tetramer interface; other site 536056003822 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 536056003823 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 536056003824 thymidine kinase; Provisional; Region: PRK04296 536056003825 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 536056003826 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 536056003827 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 536056003828 putative catalytic cysteine [active] 536056003829 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 536056003830 putative active site [active] 536056003831 metal binding site [ion binding]; metal-binding site 536056003832 hypothetical protein; Provisional; Region: PRK11111 536056003833 Transposase domain (DUF772); Region: DUF772; pfam05598 536056003834 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 536056003835 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 536056003836 'oligopeptide transporter subunit -!-periplasmic-binding component of ABC superfamily, pseudogene fragment due to insertion' 536056003837 IS2 repressor TnpA; Reviewed; Region: PRK09413 536056003838 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 536056003839 IS2 transposase TnpB; Reviewed; Region: PRK09409 536056003840 HTH-like domain; Region: HTH_21; pfam13276 536056003841 Integrase core domain; Region: rve; pfam00665 536056003842 Integrase core domain; Region: rve_3; pfam13683 536056003843 'function: ABC-type oligopeptide transport system, periplasmic component; oligopeptide transporter subunit, pseudogene fragment due to insertion' 536056003844 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 536056003845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056003846 dimer interface [polypeptide binding]; other site 536056003847 conserved gate region; other site 536056003848 putative PBP binding loops; other site 536056003849 ABC-ATPase subunit interface; other site 536056003850 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 536056003851 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 536056003852 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056003853 dimer interface [polypeptide binding]; other site 536056003854 conserved gate region; other site 536056003855 putative PBP binding loops; other site 536056003856 ABC-ATPase subunit interface; other site 536056003857 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 536056003858 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536056003859 Walker A/P-loop; other site 536056003860 ATP binding site [chemical binding]; other site 536056003861 Q-loop/lid; other site 536056003862 ABC transporter signature motif; other site 536056003863 Walker B; other site 536056003864 D-loop; other site 536056003865 H-loop/switch region; other site 536056003866 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 536056003867 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 536056003868 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536056003869 Walker A/P-loop; other site 536056003870 ATP binding site [chemical binding]; other site 536056003871 Q-loop/lid; other site 536056003872 ABC transporter signature motif; other site 536056003873 Walker B; other site 536056003874 D-loop; other site 536056003875 H-loop/switch region; other site 536056003876 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 536056003877 dsDNA-mimic protein; Reviewed; Region: PRK05094 536056003878 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 536056003879 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 536056003880 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 536056003881 putative active site [active] 536056003882 catalytic site [active] 536056003883 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 536056003884 putative active site [active] 536056003885 catalytic site [active] 536056003886 voltage-gated potassium channel; Provisional; Region: PRK10537 536056003887 Ion channel; Region: Ion_trans_2; pfam07885 536056003888 TrkA-N domain; Region: TrkA_N; pfam02254 536056003889 YciI-like protein; Reviewed; Region: PRK11370 536056003890 transport protein TonB; Provisional; Region: PRK10819 536056003891 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 536056003892 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 536056003893 intracellular septation protein A; Reviewed; Region: PRK00259 536056003894 hypothetical protein; Provisional; Region: PRK02868 536056003895 outer membrane protein W; Provisional; Region: PRK10959 536056003896 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 536056003897 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 536056003898 dimerization interface [polypeptide binding]; other site 536056003899 metal binding site [ion binding]; metal-binding site 536056003900 General stress protein [General function prediction only]; Region: GsiB; COG3729 536056003901 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 536056003902 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 536056003903 substrate binding site [chemical binding]; other site 536056003904 active site 536056003905 catalytic residues [active] 536056003906 heterodimer interface [polypeptide binding]; other site 536056003907 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 536056003908 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 536056003909 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056003910 catalytic residue [active] 536056003911 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 536056003912 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 536056003913 active site 536056003914 ribulose/triose binding site [chemical binding]; other site 536056003915 phosphate binding site [ion binding]; other site 536056003916 substrate (anthranilate) binding pocket [chemical binding]; other site 536056003917 product (indole) binding pocket [chemical binding]; other site 536056003918 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 536056003919 active site 536056003920 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 536056003921 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 536056003922 glutamine binding [chemical binding]; other site 536056003923 catalytic triad [active] 536056003924 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 536056003925 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 536056003926 anthranilate synthase component I; Provisional; Region: PRK13564 536056003927 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 536056003928 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 536056003929 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 536056003930 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 536056003931 active site 536056003932 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 536056003933 hypothetical protein; Provisional; Region: PRK11630 536056003934 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 536056003935 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 536056003936 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 536056003937 RNA binding surface [nucleotide binding]; other site 536056003938 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 536056003939 probable active site [active] 536056003940 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 536056003941 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 536056003942 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 536056003943 homodimer interface [polypeptide binding]; other site 536056003944 Walker A motif; other site 536056003945 ATP binding site [chemical binding]; other site 536056003946 hydroxycobalamin binding site [chemical binding]; other site 536056003947 Walker B motif; other site 536056003948 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 536056003949 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 536056003950 NADP binding site [chemical binding]; other site 536056003951 homodimer interface [polypeptide binding]; other site 536056003952 active site 536056003953 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 536056003954 putative inner membrane peptidase; Provisional; Region: PRK11778 536056003955 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 536056003956 tandem repeat interface [polypeptide binding]; other site 536056003957 oligomer interface [polypeptide binding]; other site 536056003958 active site residues [active] 536056003959 hypothetical protein; Provisional; Region: PRK11037 536056003960 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 536056003961 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 536056003962 active site 536056003963 interdomain interaction site; other site 536056003964 putative metal-binding site [ion binding]; other site 536056003965 nucleotide binding site [chemical binding]; other site 536056003966 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 536056003967 domain I; other site 536056003968 DNA binding groove [nucleotide binding] 536056003969 phosphate binding site [ion binding]; other site 536056003970 domain II; other site 536056003971 domain III; other site 536056003972 nucleotide binding site [chemical binding]; other site 536056003973 catalytic site [active] 536056003974 domain IV; other site 536056003975 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 536056003976 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 536056003977 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 536056003978 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 536056003979 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 536056003980 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056003981 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 536056003982 substrate binding site [chemical binding]; other site 536056003983 putative dimerization interface [polypeptide binding]; other site 536056003984 aconitate hydratase; Validated; Region: PRK09277 536056003985 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 536056003986 substrate binding site [chemical binding]; other site 536056003987 ligand binding site [chemical binding]; other site 536056003988 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 536056003989 substrate binding site [chemical binding]; other site 536056003990 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 536056003991 dimerization interface [polypeptide binding]; other site 536056003992 active site 536056003993 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 536056003994 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 536056003995 active site 536056003996 Predicted membrane protein [Function unknown]; Region: COG3771 536056003997 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 536056003998 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 536056003999 TPR motif; other site 536056004000 binding surface 536056004001 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536056004002 binding surface 536056004003 TPR motif; other site 536056004004 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 536056004005 active site 536056004006 dimer interface [polypeptide binding]; other site 536056004007 translation initiation factor Sui1; Validated; Region: PRK06824 536056004008 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 536056004009 putative rRNA binding site [nucleotide binding]; other site 536056004010 lipoprotein; Provisional; Region: PRK10540 536056004011 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 536056004012 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 536056004013 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 536056004014 hypothetical protein; Provisional; Region: PRK13658 536056004015 RNase II stability modulator; Provisional; Region: PRK10060 536056004016 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536056004017 putative active site [active] 536056004018 heme pocket [chemical binding]; other site 536056004019 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 536056004020 metal binding site [ion binding]; metal-binding site 536056004021 active site 536056004022 I-site; other site 536056004023 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 536056004024 exoribonuclease II; Provisional; Region: PRK05054 536056004025 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 536056004026 RNB domain; Region: RNB; pfam00773 536056004027 S1 RNA binding domain; Region: S1; pfam00575 536056004028 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 536056004029 Uncharacterized conserved protein [Function unknown]; Region: COG2128 536056004030 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 536056004031 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 536056004032 NAD binding site [chemical binding]; other site 536056004033 homotetramer interface [polypeptide binding]; other site 536056004034 homodimer interface [polypeptide binding]; other site 536056004035 substrate binding site [chemical binding]; other site 536056004036 active site 536056004037 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 536056004038 putative active site [active] 536056004039 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 536056004040 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536056004041 Walker A/P-loop; other site 536056004042 ATP binding site [chemical binding]; other site 536056004043 Q-loop/lid; other site 536056004044 ABC transporter signature motif; other site 536056004045 Walker B; other site 536056004046 D-loop; other site 536056004047 H-loop/switch region; other site 536056004048 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 536056004049 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536056004050 Walker A/P-loop; other site 536056004051 ATP binding site [chemical binding]; other site 536056004052 Q-loop/lid; other site 536056004053 ABC transporter signature motif; other site 536056004054 Walker B; other site 536056004055 D-loop; other site 536056004056 H-loop/switch region; other site 536056004057 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 536056004058 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 536056004059 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 536056004060 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056004061 dimer interface [polypeptide binding]; other site 536056004062 conserved gate region; other site 536056004063 putative PBP binding loops; other site 536056004064 ABC-ATPase subunit interface; other site 536056004065 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 536056004066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056004067 dimer interface [polypeptide binding]; other site 536056004068 conserved gate region; other site 536056004069 putative PBP binding loops; other site 536056004070 ABC-ATPase subunit interface; other site 536056004071 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 536056004072 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 536056004073 peptide binding site [polypeptide binding]; other site 536056004074 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 536056004075 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 536056004076 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 536056004077 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 536056004078 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 536056004079 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 536056004080 catalytic triad [active] 536056004081 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 536056004082 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536056004083 non-specific DNA binding site [nucleotide binding]; other site 536056004084 salt bridge; other site 536056004085 sequence-specific DNA binding site [nucleotide binding]; other site 536056004086 Cupin domain; Region: Cupin_2; pfam07883 536056004087 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 536056004088 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 536056004089 NAD(P) binding site [chemical binding]; other site 536056004090 catalytic residues [active] 536056004091 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 536056004092 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 536056004093 4-aminobutyrate transaminase; Provisional; Region: PRK09792 536056004094 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 536056004095 inhibitor-cofactor binding pocket; inhibition site 536056004096 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056004097 catalytic residue [active] 536056004098 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 536056004099 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536056004100 Walker A motif; other site 536056004101 ATP binding site [chemical binding]; other site 536056004102 Walker B motif; other site 536056004103 arginine finger; other site 536056004104 phage shock protein PspA; Provisional; Region: PRK10698 536056004105 phage shock protein B; Provisional; Region: pspB; PRK09458 536056004106 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 536056004107 phage shock protein C; Region: phageshock_pspC; TIGR02978 536056004108 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 536056004109 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 536056004110 active site residue [active] 536056004111 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 536056004112 sucrose phosphorylase; Provisional; Region: PRK13840 536056004113 active site 536056004114 homodimer interface [polypeptide binding]; other site 536056004115 catalytic site [active] 536056004116 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 536056004117 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 536056004118 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 536056004119 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056004120 dimer interface [polypeptide binding]; other site 536056004121 conserved gate region; other site 536056004122 putative PBP binding loops; other site 536056004123 ABC-ATPase subunit interface; other site 536056004124 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 536056004125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056004126 dimer interface [polypeptide binding]; other site 536056004127 conserved gate region; other site 536056004128 putative PBP binding loops; other site 536056004129 ABC-ATPase subunit interface; other site 536056004130 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 536056004131 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 536056004132 putative NAD(P) binding site [chemical binding]; other site 536056004133 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 536056004134 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 536056004135 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 536056004136 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 536056004137 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 536056004138 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 536056004139 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 536056004140 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 536056004141 beta-phosphoglucomutase; Region: bPGM; TIGR01990 536056004142 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536056004143 motif II; other site 536056004144 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 536056004145 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 536056004146 Walker A/P-loop; other site 536056004147 ATP binding site [chemical binding]; other site 536056004148 Q-loop/lid; other site 536056004149 ABC transporter signature motif; other site 536056004150 Walker B; other site 536056004151 D-loop; other site 536056004152 H-loop/switch region; other site 536056004153 TOBE domain; Region: TOBE_2; pfam08402 536056004154 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 536056004155 Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381 536056004156 Transcriptional regulators [Transcription]; Region: PurR; COG1609 536056004157 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 536056004158 DNA binding site [nucleotide binding] 536056004159 domain linker motif; other site 536056004160 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 536056004161 putative dimerization interface [polypeptide binding]; other site 536056004162 putative ligand binding site [chemical binding]; other site 536056004163 Predicted ATPase [General function prediction only]; Region: COG3106 536056004164 hypothetical protein; Provisional; Region: PRK05415 536056004165 TIGR01620 family protein; Region: hyp_HI0043 536056004166 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 536056004167 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 536056004168 putative aromatic amino acid binding site; other site 536056004169 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536056004170 Walker A motif; other site 536056004171 ATP binding site [chemical binding]; other site 536056004172 Walker B motif; other site 536056004173 arginine finger; other site 536056004174 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 536056004175 dimer interface [polypeptide binding]; other site 536056004176 catalytic triad [active] 536056004177 peroxidatic and resolving cysteines [active] 536056004178 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 536056004179 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 536056004180 active site 536056004181 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 536056004182 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 536056004183 putative active site [active] 536056004184 Zn binding site [ion binding]; other site 536056004185 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536056004186 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 536056004187 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 536056004188 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536056004189 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056004190 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 536056004191 putative effector binding pocket; other site 536056004192 putative dimerization interface [polypeptide binding]; other site 536056004193 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 536056004194 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 536056004195 peptide binding site [polypeptide binding]; other site 536056004196 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 536056004197 Mechanosensitive ion channel; Region: MS_channel; pfam00924 536056004198 Transposase domain (DUF772); Region: DUF772; pfam05598 536056004199 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 536056004200 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 536056004201 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 536056004202 universal stress protein UspE; Provisional; Region: PRK11175 536056004203 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 536056004204 Ligand Binding Site [chemical binding]; other site 536056004205 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 536056004206 Ligand Binding Site [chemical binding]; other site 536056004207 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 536056004208 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 536056004209 ligand binding site [chemical binding]; other site 536056004210 flexible hinge region; other site 536056004211 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 536056004212 putative switch regulator; other site 536056004213 non-specific DNA interactions [nucleotide binding]; other site 536056004214 DNA binding site [nucleotide binding] 536056004215 sequence specific DNA binding site [nucleotide binding]; other site 536056004216 putative cAMP binding site [chemical binding]; other site 536056004217 Transposase domain (DUF772); Region: DUF772; pfam05598 536056004218 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 536056004219 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 536056004220 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 536056004221 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 536056004222 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 536056004223 DNA binding site [nucleotide binding] 536056004224 active site 536056004225 putative aminobenzoyl-glutamate transporter; Provisional; Region: abgT; PRK11339 536056004226 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 536056004227 'predicted peptidase, aminobenzoyl-glutamate utilization protein, a stop codon appeared' 536056004228 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 536056004229 amidohydrolase; Region: amidohydrolases; TIGR01891 536056004230 putative metal binding site [ion binding]; other site 536056004231 dimer interface [polypeptide binding]; other site 536056004232 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 536056004233 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056004234 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 536056004235 putative substrate binding pocket [chemical binding]; other site 536056004236 putative dimerization interface [polypeptide binding]; other site 536056004237 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 536056004238 Smr domain; Region: Smr; pfam01713 536056004239 PAS domain S-box; Region: sensory_box; TIGR00229 536056004240 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536056004241 putative active site [active] 536056004242 heme pocket [chemical binding]; other site 536056004243 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 536056004244 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 536056004245 metal binding site [ion binding]; metal-binding site 536056004246 active site 536056004247 I-site; other site 536056004248 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 536056004249 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 536056004250 Cl binding site [ion binding]; other site 536056004251 oligomer interface [polypeptide binding]; other site 536056004252 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 536056004253 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 536056004254 ATP binding site [chemical binding]; other site 536056004255 Mg++ binding site [ion binding]; other site 536056004256 motif III; other site 536056004257 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 536056004258 nucleotide binding region [chemical binding]; other site 536056004259 ATP-binding site [chemical binding]; other site 536056004260 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 536056004261 putative RNA binding site [nucleotide binding]; other site 536056004262 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 536056004263 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 536056004264 Ligand Binding Site [chemical binding]; other site 536056004265 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 536056004266 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 536056004267 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 536056004268 Int/Topo IB signature motif; other site 536056004269 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 536056004270 hypothetical protein; Provisional; Region: PRK09750 536056004271 restriction alleviation and modification protein; Reviewed; Region: lar; PRK09710 536056004272 recombination and repair protein RecT; Reviewed; Region: recT; PRK09846 536056004273 exonuclease VIII; Reviewed; Region: PRK09709 536056004274 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 536056004275 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 536056004276 hypothetical protein; Reviewed; Region: PRK09790 536056004277 FtsZ inhibitor protein; Reviewed; Region: kil; PRK11354 536056004278 Superinfection exclusion protein B; Region: SieB; pfam14163 536056004279 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 536056004280 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536056004281 sequence-specific DNA binding site [nucleotide binding]; other site 536056004282 salt bridge; other site 536056004283 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 536056004284 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3756 536056004285 primosomal protein DnaI; Provisional; Region: PRK02854 536056004286 putative replication protein; Provisional; Region: PRK12377 536056004287 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536056004288 Walker A motif; other site 536056004289 ATP binding site [chemical binding]; other site 536056004290 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 536056004291 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 536056004292 Cation transport protein; Region: TrkH; cl17365 536056004293 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 536056004294 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 536056004295 ParB-like nuclease domain; Region: ParBc; pfam02195 536056004296 Phage-related minor tail protein [Function unknown]; Region: COG5281 536056004297 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 536056004298 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 536056004299 Transposase domain (DUF772); Region: DUF772; pfam05598 536056004300 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 536056004301 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 536056004302 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 536056004303 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 536056004304 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 536056004305 Phage Tail Collar Domain; Region: Collar; pfam07484 536056004306 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 536056004307 multiple promoter invertase; Provisional; Region: mpi; PRK13413 536056004308 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 536056004309 catalytic residues [active] 536056004310 catalytic nucleophile [active] 536056004311 Presynaptic Site I dimer interface [polypeptide binding]; other site 536056004312 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 536056004313 Synaptic Flat tetramer interface [polypeptide binding]; other site 536056004314 Synaptic Site I dimer interface [polypeptide binding]; other site 536056004315 DNA binding site [nucleotide binding] 536056004316 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 536056004317 DNA-binding interface [nucleotide binding]; DNA binding site 536056004318 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 536056004319 Ligand Binding Site [chemical binding]; other site 536056004320 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 536056004321 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 536056004322 trimer interface [polypeptide binding]; other site 536056004323 eyelet of channel; other site 536056004324 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 536056004325 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 536056004326 dimer interface [polypeptide binding]; other site 536056004327 PYR/PP interface [polypeptide binding]; other site 536056004328 TPP binding site [chemical binding]; other site 536056004329 substrate binding site [chemical binding]; other site 536056004330 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 536056004331 Domain of unknown function; Region: EKR; smart00890 536056004332 4Fe-4S binding domain; Region: Fer4_6; pfam12837 536056004333 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 536056004334 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 536056004335 TPP-binding site [chemical binding]; other site 536056004336 dimer interface [polypeptide binding]; other site 536056004337 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 536056004338 Domain of unknown function (DUF333); Region: DUF333; pfam03891 536056004339 heat-inducible protein; Provisional; Region: PRK10449 536056004340 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 536056004341 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 536056004342 putative ligand binding site [chemical binding]; other site 536056004343 putative NAD binding site [chemical binding]; other site 536056004344 catalytic site [active] 536056004345 hypothetical protein; Provisional; Region: PRK10695 536056004346 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 536056004347 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 536056004348 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 536056004349 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536056004350 Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; Region: ALDH_PADH_NahF; cd07113 536056004351 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 536056004352 NAD(P) binding site [chemical binding]; other site 536056004353 catalytic residues [active] 536056004354 tyramine oxidase; Provisional; Region: tynA; PRK14696 536056004355 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 536056004356 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 536056004357 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 536056004358 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 536056004359 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 536056004360 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 536056004361 substrate binding site [chemical binding]; other site 536056004362 dimer interface [polypeptide binding]; other site 536056004363 NADP binding site [chemical binding]; other site 536056004364 catalytic residues [active] 536056004365 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 536056004366 substrate binding site [chemical binding]; other site 536056004367 'predicted multicomponent oxygenase/reductase subunit for phenylacetic acid degradation, a stop codon appeared' 536056004368 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 536056004369 phenylacetate-CoA oxygenase, PaaI subunit; Region: PA_CoA_Oxy3; TIGR02158 536056004370 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 536056004371 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 536056004372 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 536056004373 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 536056004374 FAD binding pocket [chemical binding]; other site 536056004375 FAD binding motif [chemical binding]; other site 536056004376 phosphate binding motif [ion binding]; other site 536056004377 beta-alpha-beta structure motif; other site 536056004378 NAD(p) ribose binding residues [chemical binding]; other site 536056004379 NAD binding pocket [chemical binding]; other site 536056004380 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 536056004381 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 536056004382 catalytic loop [active] 536056004383 iron binding site [ion binding]; other site 536056004384 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 536056004385 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 536056004386 substrate binding site [chemical binding]; other site 536056004387 oxyanion hole (OAH) forming residues; other site 536056004388 trimer interface [polypeptide binding]; other site 536056004389 enoyl-CoA hydratase; Provisional; Region: PRK08140 536056004390 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 536056004391 substrate binding site [chemical binding]; other site 536056004392 oxyanion hole (OAH) forming residues; other site 536056004393 trimer interface [polypeptide binding]; other site 536056004394 3-hydroxyacyl-CoA dehydrogenase PaaC; Region: PaaC-3OHAcCoADH; TIGR02279 536056004395 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 536056004396 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 536056004397 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 536056004398 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 536056004399 CoenzymeA binding site [chemical binding]; other site 536056004400 subunit interaction site [polypeptide binding]; other site 536056004401 PHB binding site; other site 536056004402 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 536056004403 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 536056004404 dimer interface [polypeptide binding]; other site 536056004405 active site 536056004406 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 536056004407 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 536056004408 active site 536056004409 AMP binding site [chemical binding]; other site 536056004410 homodimer interface [polypeptide binding]; other site 536056004411 acyl-activating enzyme (AAE) consensus motif; other site 536056004412 CoA binding site [chemical binding]; other site 536056004413 PaaX-like protein; Region: PaaX; pfam07848 536056004414 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 536056004415 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 536056004416 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 536056004417 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 536056004418 putative trimer interface [polypeptide binding]; other site 536056004419 putative metal binding site [ion binding]; other site 536056004420 IS2 transposase TnpB; Reviewed; Region: PRK09409 536056004421 HTH-like domain; Region: HTH_21; pfam13276 536056004422 Integrase core domain; Region: rve; pfam00665 536056004423 Integrase core domain; Region: rve_3; pfam13683 536056004424 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 536056004425 Helix-turn-helix domain; Region: HTH_38; pfam13936 536056004426 Integrase core domain; Region: rve; pfam00665 536056004427 Autotransporter beta-domain; Region: Autotransporter; pfam03797 536056004428 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 536056004429 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 536056004430 active site 536056004431 catalytic tetrad [active] 536056004432 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 536056004433 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 536056004434 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 536056004435 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 536056004436 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 536056004437 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 536056004438 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 536056004439 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536056004440 S-adenosylmethionine binding site [chemical binding]; other site 536056004441 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 536056004442 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 536056004443 active site 536056004444 Dual specificity phosphatase, catalytic domain; Region: DSPc; smart00195 536056004445 active site 536056004446 catalytic residues [active] 536056004447 azoreductase; Reviewed; Region: PRK00170 536056004448 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 536056004449 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 536056004450 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 536056004451 ATP binding site [chemical binding]; other site 536056004452 putative Mg++ binding site [ion binding]; other site 536056004453 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 536056004454 nucleotide binding region [chemical binding]; other site 536056004455 ATP-binding site [chemical binding]; other site 536056004456 Helicase associated domain (HA2); Region: HA2; pfam04408 536056004457 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 536056004458 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 536056004459 Uncharacterized conserved protein [Function unknown]; Region: COG1434 536056004460 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 536056004461 putative active site [active] 536056004462 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 536056004463 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 536056004464 NAD binding site [chemical binding]; other site 536056004465 catalytic residues [active] 536056004466 substrate binding site [chemical binding]; other site 536056004467 'function: Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; glyceraldehyde-3-phosphate dehydrogenase, typeI, pseudogene fragment due to insertion' 536056004468 'glyceraldehyde-3-phosphate dehydrogenase C, C-ter fragment (pseudogene), pseudogene fragment due to insertion' 536056004469 cytochrome b561; Provisional; Region: PRK11513 536056004470 hypothetical protein; Provisional; Region: PRK10040 536056004471 small toxic polypeptide; Provisional; Region: PRK09738 536056004472 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 536056004473 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 536056004474 dimer interface [polypeptide binding]; other site 536056004475 ligand binding site [chemical binding]; other site 536056004476 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 536056004477 dimerization interface [polypeptide binding]; other site 536056004478 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 536056004479 dimer interface [polypeptide binding]; other site 536056004480 putative CheW interface [polypeptide binding]; other site 536056004481 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 536056004482 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056004483 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 536056004484 dimerization interface [polypeptide binding]; other site 536056004485 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 536056004486 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 536056004487 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 536056004488 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 536056004489 hypothetical protein; Provisional; Region: PRK11415 536056004490 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 536056004491 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536056004492 Coenzyme A binding pocket [chemical binding]; other site 536056004493 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 536056004494 putative trimer interface [polypeptide binding]; other site 536056004495 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 536056004496 putative CoA binding site [chemical binding]; other site 536056004497 putative trimer interface [polypeptide binding]; other site 536056004498 putative CoA binding site [chemical binding]; other site 536056004499 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 536056004500 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 536056004501 gating phenylalanine in ion channel; other site 536056004502 tellurite resistance protein TehB; Provisional; Region: PRK11207 536056004503 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536056004504 S-adenosylmethionine binding site [chemical binding]; other site 536056004505 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 536056004506 Transposase IS200 like; Region: Y1_Tnp; cl00848 536056004507 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 536056004508 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 536056004509 Probable transposase; Region: OrfB_IS605; pfam01385 536056004510 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 536056004511 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 536056004512 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 536056004513 benzoate transporter; Region: benE; TIGR00843 536056004514 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 536056004515 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536056004516 non-specific DNA binding site [nucleotide binding]; other site 536056004517 salt bridge; other site 536056004518 sequence-specific DNA binding site [nucleotide binding]; other site 536056004519 Cupin domain; Region: Cupin_2; pfam07883 536056004520 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 536056004521 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 536056004522 Peptidase family U32; Region: Peptidase_U32; pfam01136 536056004523 Collagenase; Region: DUF3656; pfam12392 536056004524 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 536056004525 YcfA-like protein; Region: YcfA; pfam07927 536056004526 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 536056004527 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536056004528 sequence-specific DNA binding site [nucleotide binding]; other site 536056004529 salt bridge; other site 536056004530 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 536056004531 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536056004532 DNA-binding site [nucleotide binding]; DNA binding site 536056004533 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 536056004534 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056004535 homodimer interface [polypeptide binding]; other site 536056004536 catalytic residue [active] 536056004537 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 536056004538 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 536056004539 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 536056004540 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536056004541 Walker A/P-loop; other site 536056004542 ATP binding site [chemical binding]; other site 536056004543 Q-loop/lid; other site 536056004544 ABC transporter signature motif; other site 536056004545 Walker B; other site 536056004546 D-loop; other site 536056004547 H-loop/switch region; other site 536056004548 TOBE domain; Region: TOBE_2; pfam08402 536056004549 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056004550 dimer interface [polypeptide binding]; other site 536056004551 conserved gate region; other site 536056004552 putative PBP binding loops; other site 536056004553 ABC-ATPase subunit interface; other site 536056004554 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 536056004555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056004556 ABC-ATPase subunit interface; other site 536056004557 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 536056004558 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 536056004559 tetrameric interface [polypeptide binding]; other site 536056004560 NAD binding site [chemical binding]; other site 536056004561 catalytic residues [active] 536056004562 substrate binding site [chemical binding]; other site 536056004563 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 536056004564 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 536056004565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 536056004566 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 536056004567 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 536056004568 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 536056004569 Prostaglandin dehydrogenases; Region: PGDH; cd05288 536056004570 NAD(P) binding site [chemical binding]; other site 536056004571 substrate binding site [chemical binding]; other site 536056004572 dimer interface [polypeptide binding]; other site 536056004573 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 536056004574 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536056004575 DNA-binding site [nucleotide binding]; DNA binding site 536056004576 FCD domain; Region: FCD; pfam07729 536056004577 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 536056004578 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 536056004579 N-terminal plug; other site 536056004580 ligand-binding site [chemical binding]; other site 536056004581 PQQ-like domain; Region: PQQ_2; pfam13360 536056004582 L-asparagine permease; Provisional; Region: PRK15049 536056004583 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 536056004584 C-terminal domain interface [polypeptide binding]; other site 536056004585 GSH binding site (G-site) [chemical binding]; other site 536056004586 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 536056004587 dimer interface [polypeptide binding]; other site 536056004588 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 536056004589 dimer interface [polypeptide binding]; other site 536056004590 N-terminal domain interface [polypeptide binding]; other site 536056004591 substrate binding pocket (H-site) [chemical binding]; other site 536056004592 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 536056004593 RHS protein; Region: RHS; pfam03527 536056004594 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 536056004595 potential frameshift: common BLAST hit: gi|291281062|ref|YP_003497880.1| transposase yncI 536056004596 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 536056004597 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 536056004598 Transposase [DNA replication, recombination, and repair]; Region: COG5433 536056004599 Transposase [DNA replication, recombination, and repair]; Region: COG5433 536056004600 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 536056004601 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 536056004602 Transposase [DNA replication, recombination, and repair]; Region: COG5433 536056004603 Transposase [DNA replication, recombination, and repair]; Region: COG5433 536056004604 4-oxalocrotonate tautomerase; Provisional; Region: PRK01271 536056004605 active site 1 [active] 536056004606 dimer interface [polypeptide binding]; other site 536056004607 hexamer interface [polypeptide binding]; other site 536056004608 active site 2 [active] 536056004609 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 536056004610 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 536056004611 hypothetical protein; Provisional; Region: PRK10281 536056004612 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 536056004613 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 536056004614 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 536056004615 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 536056004616 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 536056004617 [4Fe-4S] binding site [ion binding]; other site 536056004618 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 536056004619 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 536056004620 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 536056004621 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 536056004622 molybdopterin cofactor binding site; other site 536056004623 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 536056004624 potential frameshift: common BLAST hit: gi|260843778|ref|YP_003221556.1| T3SS effector-like protein EspR-homolog 536056004625 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 536056004626 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 536056004627 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 536056004628 aromatic amino acid exporter; Provisional; Region: PRK11689 536056004629 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 536056004630 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 536056004631 [4Fe-4S] binding site [ion binding]; other site 536056004632 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 536056004633 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 536056004634 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 536056004635 molybdopterin cofactor binding site; other site 536056004636 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 536056004637 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 536056004638 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 536056004639 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 536056004640 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 536056004641 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536056004642 non-specific DNA binding site [nucleotide binding]; other site 536056004643 salt bridge; other site 536056004644 sequence-specific DNA binding site [nucleotide binding]; other site 536056004645 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 536056004646 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 536056004647 NAD binding site [chemical binding]; other site 536056004648 substrate binding site [chemical binding]; other site 536056004649 catalytic Zn binding site [ion binding]; other site 536056004650 tetramer interface [polypeptide binding]; other site 536056004651 structural Zn binding site [ion binding]; other site 536056004652 malate dehydrogenase; Provisional; Region: PRK13529 536056004653 Malic enzyme, N-terminal domain; Region: malic; pfam00390 536056004654 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 536056004655 NAD(P) binding site [chemical binding]; other site 536056004656 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 536056004657 Putative biofilm-dependent modulation protein; Region: BDM; cl11581 536056004658 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 536056004659 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 536056004660 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536056004661 Walker A/P-loop; other site 536056004662 ATP binding site [chemical binding]; other site 536056004663 Q-loop/lid; other site 536056004664 ABC transporter signature motif; other site 536056004665 Walker B; other site 536056004666 D-loop; other site 536056004667 H-loop/switch region; other site 536056004668 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 536056004669 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 536056004670 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536056004671 Walker A/P-loop; other site 536056004672 ATP binding site [chemical binding]; other site 536056004673 Q-loop/lid; other site 536056004674 ABC transporter signature motif; other site 536056004675 Walker B; other site 536056004676 D-loop; other site 536056004677 H-loop/switch region; other site 536056004678 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 536056004679 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 536056004680 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 536056004681 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056004682 dimer interface [polypeptide binding]; other site 536056004683 conserved gate region; other site 536056004684 putative PBP binding loops; other site 536056004685 ABC-ATPase subunit interface; other site 536056004686 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 536056004687 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056004688 dimer interface [polypeptide binding]; other site 536056004689 conserved gate region; other site 536056004690 putative PBP binding loops; other site 536056004691 ABC-ATPase subunit interface; other site 536056004692 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 536056004693 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 536056004694 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 536056004695 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 536056004696 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536056004697 putative active site [active] 536056004698 heme pocket [chemical binding]; other site 536056004699 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536056004700 putative active site [active] 536056004701 heme pocket [chemical binding]; other site 536056004702 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 536056004703 metal binding site [ion binding]; metal-binding site 536056004704 active site 536056004705 I-site; other site 536056004706 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 536056004707 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 536056004708 heme-binding site [chemical binding]; other site 536056004709 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 536056004710 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 536056004711 metal binding site [ion binding]; metal-binding site 536056004712 active site 536056004713 I-site; other site 536056004714 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 536056004715 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 536056004716 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 536056004717 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 536056004718 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056004719 catalytic residue [active] 536056004720 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 536056004721 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 536056004722 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 536056004723 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 536056004724 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 536056004725 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 536056004726 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 536056004727 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 536056004728 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 536056004729 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 536056004730 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 536056004731 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 536056004732 FeS/SAM binding site; other site 536056004733 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 536056004734 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 536056004735 Sulfatase; Region: Sulfatase; pfam00884 536056004736 transcriptional regulator YdeO; Provisional; Region: PRK09940 536056004737 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536056004738 putative oxidoreductase; Provisional; Region: PRK09939 536056004739 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 536056004740 putative molybdopterin cofactor binding site [chemical binding]; other site 536056004741 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 536056004742 putative molybdopterin cofactor binding site; other site 536056004743 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 536056004744 mannosyl binding site [chemical binding]; other site 536056004745 Fimbrial protein; Region: Fimbrial; pfam00419 536056004746 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 536056004747 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 536056004748 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 536056004749 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 536056004750 PapC C-terminal domain; Region: PapC_C; pfam13953 536056004751 Helix-turn-helix domain; Region: HTH_18; pfam12833 536056004752 HipA N-terminal domain; Region: Couple_hipA; pfam13657 536056004753 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 536056004754 HipA-like N-terminal domain; Region: HipA_N; pfam07805 536056004755 HipA-like C-terminal domain; Region: HipA_C; pfam07804 536056004756 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 536056004757 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536056004758 non-specific DNA binding site [nucleotide binding]; other site 536056004759 salt bridge; other site 536056004760 sequence-specific DNA binding site [nucleotide binding]; other site 536056004761 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 536056004762 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 536056004763 Autotransporter beta-domain; Region: Autotransporter; pfam03797 536056004764 putative lipoprotein; Provisional; Region: PRK09707 536056004765 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 536056004766 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 536056004767 putative N- and C-terminal domain interface [polypeptide binding]; other site 536056004768 putative active site [active] 536056004769 putative MgATP binding site [chemical binding]; other site 536056004770 catalytic site [active] 536056004771 metal binding site [ion binding]; metal-binding site 536056004772 putative carbohydrate binding site [chemical binding]; other site 536056004773 transcriptional regulator LsrR; Provisional; Region: PRK15418 536056004774 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 536056004775 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 536056004776 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 536056004777 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536056004778 Walker A/P-loop; other site 536056004779 ATP binding site [chemical binding]; other site 536056004780 Q-loop/lid; other site 536056004781 ABC transporter signature motif; other site 536056004782 Walker B; other site 536056004783 D-loop; other site 536056004784 H-loop/switch region; other site 536056004785 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 536056004786 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536056004787 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536056004788 TM-ABC transporter signature motif; other site 536056004789 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536056004790 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536056004791 TM-ABC transporter signature motif; other site 536056004792 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 536056004793 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 536056004794 ligand binding site [chemical binding]; other site 536056004795 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 536056004796 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 536056004797 putative active site; other site 536056004798 catalytic residue [active] 536056004799 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 536056004800 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 536056004801 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536056004802 S-adenosylmethionine binding site [chemical binding]; other site 536056004803 Predicted membrane protein [Function unknown]; Region: COG3781 536056004804 altronate oxidoreductase; Provisional; Region: PRK03643 536056004805 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 536056004806 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 536056004807 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 536056004808 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 536056004809 metal binding site [ion binding]; metal-binding site 536056004810 active site 536056004811 I-site; other site 536056004812 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 536056004813 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 536056004814 glutaminase; Provisional; Region: PRK00971 536056004815 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 536056004816 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 536056004817 NAD(P) binding site [chemical binding]; other site 536056004818 catalytic residues [active] 536056004819 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536056004820 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056004821 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 536056004822 putative dimerization interface [polypeptide binding]; other site 536056004823 putative arabinose transporter; Provisional; Region: PRK03545 536056004824 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056004825 putative substrate translocation pore; other site 536056004826 inner membrane protein; Provisional; Region: PRK10995 536056004827 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 536056004828 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 536056004829 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 536056004830 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536056004831 hypothetical protein; Provisional; Region: PRK10106 536056004832 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 536056004833 EamA-like transporter family; Region: EamA; pfam00892 536056004834 EamA-like transporter family; Region: EamA; pfam00892 536056004835 putative transporter; Provisional; Region: PRK10054 536056004836 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056004837 putative substrate translocation pore; other site 536056004838 diguanylate cyclase; Provisional; Region: PRK09894 536056004839 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 536056004840 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 536056004841 metal binding site [ion binding]; metal-binding site 536056004842 active site 536056004843 I-site; other site 536056004844 hypothetical protein; Provisional; Region: PRK10053 536056004845 hypothetical protein; Validated; Region: PRK03657 536056004846 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 536056004847 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 536056004848 active site 536056004849 Zn binding site [ion binding]; other site 536056004850 malonic semialdehyde reductase; Provisional; Region: PRK10538 536056004851 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 536056004852 putative NAD(P) binding site [chemical binding]; other site 536056004853 homodimer interface [polypeptide binding]; other site 536056004854 homotetramer interface [polypeptide binding]; other site 536056004855 active site 536056004856 Transcriptional regulators [Transcription]; Region: GntR; COG1802 536056004857 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536056004858 DNA-binding site [nucleotide binding]; DNA binding site 536056004859 FCD domain; Region: FCD; pfam07729 536056004860 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 536056004861 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 536056004862 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 536056004863 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 536056004864 metabolite-proton symporter; Region: 2A0106; TIGR00883 536056004865 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056004866 putative substrate translocation pore; other site 536056004867 multiple promoter invertase; Provisional; Region: mpi; PRK13413 536056004868 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 536056004869 catalytic residues [active] 536056004870 catalytic nucleophile [active] 536056004871 Presynaptic Site I dimer interface [polypeptide binding]; other site 536056004872 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 536056004873 Synaptic Flat tetramer interface [polypeptide binding]; other site 536056004874 Synaptic Site I dimer interface [polypeptide binding]; other site 536056004875 DNA binding site [nucleotide binding] 536056004876 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 536056004877 DNA-binding interface [nucleotide binding]; DNA binding site 536056004878 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 536056004879 Phage Tail Collar Domain; Region: Collar; pfam07484 536056004880 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 536056004881 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 536056004882 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 536056004883 GnsA/GnsB family; Region: GnsAB; pfam08178 536056004884 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 536056004885 DNA-binding site [nucleotide binding]; DNA binding site 536056004886 RNA-binding motif; other site 536056004887 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 536056004888 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 536056004889 catalytic residues [active] 536056004890 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 536056004891 Lysis protein S; Region: Lysis_S; pfam04971 536056004892 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 536056004893 DNA-binding site [nucleotide binding]; DNA binding site 536056004894 RNA-binding motif; other site 536056004895 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 536056004896 DNA-binding site [nucleotide binding]; DNA binding site 536056004897 RNA-binding motif; other site 536056004898 Antitermination protein; Region: Antiterm; pfam03589 536056004899 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 536056004900 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 536056004901 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 536056004902 Protein of unknown function (DUF968); Region: DUF968; pfam06147 536056004903 Hok/gef family; Region: HOK_GEF; pfam01848 536056004904 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 536056004905 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 536056004906 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 536056004907 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 536056004908 transcriptional repressor DicA; Reviewed; Region: PRK09706 536056004909 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536056004910 non-specific DNA binding site [nucleotide binding]; other site 536056004911 salt bridge; other site 536056004912 sequence-specific DNA binding site [nucleotide binding]; other site 536056004913 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 536056004914 DicB protein; Region: DicB; pfam05358 536056004915 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 536056004916 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 536056004917 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 536056004918 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 536056004919 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 536056004920 Int/Topo IB signature motif; other site 536056004921 putative oxidoreductase; Provisional; Region: PRK10083 536056004922 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 536056004923 putative NAD(P) binding site [chemical binding]; other site 536056004924 catalytic Zn binding site [ion binding]; other site 536056004925 structural Zn binding site [ion binding]; other site 536056004926 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 536056004927 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 536056004928 putative active site pocket [active] 536056004929 putative metal binding site [ion binding]; other site 536056004930 hypothetical protein; Provisional; Region: PRK02237 536056004931 hypothetical protein; Provisional; Region: PRK13659 536056004932 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 536056004933 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536056004934 Coenzyme A binding pocket [chemical binding]; other site 536056004935 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 536056004936 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 536056004937 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 536056004938 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 536056004939 putative [Fe4-S4] binding site [ion binding]; other site 536056004940 putative molybdopterin cofactor binding site [chemical binding]; other site 536056004941 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 536056004942 putative molybdopterin cofactor binding site; other site 536056004943 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 536056004944 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 536056004945 putative [Fe4-S4] binding site [ion binding]; other site 536056004946 putative molybdopterin cofactor binding site [chemical binding]; other site 536056004947 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 536056004948 putative molybdopterin cofactor binding site; other site 536056004949 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 536056004950 4Fe-4S binding domain; Region: Fer4; cl02805 536056004951 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 536056004952 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 536056004953 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 536056004954 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 536056004955 Cl- selectivity filter; other site 536056004956 Cl- binding residues [ion binding]; other site 536056004957 pore gating glutamate residue; other site 536056004958 dimer interface [polypeptide binding]; other site 536056004959 putative dithiobiotin synthetase; Provisional; Region: PRK12374 536056004960 AAA domain; Region: AAA_26; pfam13500 536056004961 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 536056004962 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 536056004963 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 536056004964 nucleotide binding site [chemical binding]; other site 536056004965 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 536056004966 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056004967 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 536056004968 dimerization interface [polypeptide binding]; other site 536056004969 substrate binding pocket [chemical binding]; other site 536056004970 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 536056004971 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056004972 putative substrate translocation pore; other site 536056004973 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 536056004974 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 536056004975 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 536056004976 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 536056004977 Domain of unknown function DUF20; Region: UPF0118; pfam01594 536056004978 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 536056004979 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 536056004980 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 536056004981 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 536056004982 ligand binding site [chemical binding]; other site 536056004983 homodimer interface [polypeptide binding]; other site 536056004984 NAD(P) binding site [chemical binding]; other site 536056004985 trimer interface B [polypeptide binding]; other site 536056004986 trimer interface A [polypeptide binding]; other site 536056004987 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 536056004988 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 536056004989 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 536056004990 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 536056004991 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 536056004992 Spore germination protein; Region: Spore_permease; cl17796 536056004993 dihydromonapterin reductase; Provisional; Region: PRK06483 536056004994 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 536056004995 NADP binding site [chemical binding]; other site 536056004996 substrate binding pocket [chemical binding]; other site 536056004997 active site 536056004998 GlpM protein; Region: GlpM; pfam06942 536056004999 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 536056005000 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536056005001 active site 536056005002 phosphorylation site [posttranslational modification] 536056005003 intermolecular recognition site; other site 536056005004 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 536056005005 DNA binding site [nucleotide binding] 536056005006 sensor protein RstB; Provisional; Region: PRK10604 536056005007 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 536056005008 dimerization interface [polypeptide binding]; other site 536056005009 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536056005010 dimer interface [polypeptide binding]; other site 536056005011 phosphorylation site [posttranslational modification] 536056005012 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536056005013 ATP binding site [chemical binding]; other site 536056005014 Mg2+ binding site [ion binding]; other site 536056005015 G-X-G motif; other site 536056005016 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 536056005017 fumarate hydratase; Reviewed; Region: fumC; PRK00485 536056005018 Class II fumarases; Region: Fumarase_classII; cd01362 536056005019 active site 536056005020 tetramer interface [polypeptide binding]; other site 536056005021 fumarate hydratase; Provisional; Region: PRK15389 536056005022 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 536056005023 Fumarase C-terminus; Region: Fumerase_C; pfam05683 536056005024 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 536056005025 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 536056005026 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 536056005027 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 536056005028 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 536056005029 putative outer membrane porin protein; Provisional; Region: PRK11379 536056005030 glucuronide transporter; Provisional; Region: PRK09848 536056005031 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 536056005032 beta-D-glucuronidase; Provisional; Region: PRK10150 536056005033 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 536056005034 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 536056005035 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 536056005036 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 536056005037 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536056005038 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 536056005039 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 536056005040 NAD binding site [chemical binding]; other site 536056005041 substrate binding site [chemical binding]; other site 536056005042 homotetramer interface [polypeptide binding]; other site 536056005043 homodimer interface [polypeptide binding]; other site 536056005044 active site 536056005045 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 536056005046 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 536056005047 DNA binding site [nucleotide binding] 536056005048 domain linker motif; other site 536056005049 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 536056005050 putative dimerization interface [polypeptide binding]; other site 536056005051 putative ligand binding site [chemical binding]; other site 536056005052 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 536056005053 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 536056005054 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 536056005055 active site turn [active] 536056005056 phosphorylation site [posttranslational modification] 536056005057 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 536056005058 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 536056005059 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056005060 homodimer interface [polypeptide binding]; other site 536056005061 catalytic residue [active] 536056005062 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 536056005063 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 536056005064 active site 536056005065 purine riboside binding site [chemical binding]; other site 536056005066 putative oxidoreductase; Provisional; Region: PRK11579 536056005067 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 536056005068 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 536056005069 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 536056005070 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 536056005071 electron transport complex protein RsxA; Provisional; Region: PRK05151 536056005072 electron transport complex protein RnfB; Provisional; Region: PRK05113 536056005073 Putative Fe-S cluster; Region: FeS; pfam04060 536056005074 4Fe-4S binding domain; Region: Fer4; pfam00037 536056005075 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 536056005076 SLBB domain; Region: SLBB; pfam10531 536056005077 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 536056005078 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 536056005079 electron transport complex protein RnfG; Validated; Region: PRK01908 536056005080 electron transport complex RsxE subunit; Provisional; Region: PRK12405 536056005081 endonuclease III; Provisional; Region: PRK10702 536056005082 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 536056005083 minor groove reading motif; other site 536056005084 helix-hairpin-helix signature motif; other site 536056005085 substrate binding pocket [chemical binding]; other site 536056005086 active site 536056005087 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 536056005088 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 536056005089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056005090 putative substrate translocation pore; other site 536056005091 POT family; Region: PTR2; pfam00854 536056005092 glutathionine S-transferase; Provisional; Region: PRK10542 536056005093 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 536056005094 C-terminal domain interface [polypeptide binding]; other site 536056005095 GSH binding site (G-site) [chemical binding]; other site 536056005096 dimer interface [polypeptide binding]; other site 536056005097 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 536056005098 N-terminal domain interface [polypeptide binding]; other site 536056005099 dimer interface [polypeptide binding]; other site 536056005100 substrate binding pocket (H-site) [chemical binding]; other site 536056005101 pyridoxamine kinase; Validated; Region: PRK05756 536056005102 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 536056005103 dimer interface [polypeptide binding]; other site 536056005104 pyridoxal binding site [chemical binding]; other site 536056005105 ATP binding site [chemical binding]; other site 536056005106 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 536056005107 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 536056005108 active site 536056005109 HIGH motif; other site 536056005110 dimer interface [polypeptide binding]; other site 536056005111 KMSKS motif; other site 536056005112 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 536056005113 RNA binding surface [nucleotide binding]; other site 536056005114 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 536056005115 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 536056005116 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 536056005117 lysozyme inhibitor; Provisional; Region: PRK11372 536056005118 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 536056005119 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 536056005120 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 536056005121 transcriptional regulator SlyA; Provisional; Region: PRK03573 536056005122 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 536056005123 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 536056005124 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 536056005125 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 536056005126 HlyD family secretion protein; Region: HlyD_3; pfam13437 536056005127 Fusaric acid resistance protein family; Region: FUSC; pfam04632 536056005128 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 536056005129 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 536056005130 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 536056005131 E-class dimer interface [polypeptide binding]; other site 536056005132 P-class dimer interface [polypeptide binding]; other site 536056005133 active site 536056005134 Cu2+ binding site [ion binding]; other site 536056005135 Zn2+ binding site [ion binding]; other site 536056005136 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 536056005137 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 536056005138 active site 536056005139 catalytic tetrad [active] 536056005140 Predicted Fe-S protein [General function prediction only]; Region: COG3313 536056005141 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 536056005142 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536056005143 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 536056005144 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 536056005145 FMN binding site [chemical binding]; other site 536056005146 active site 536056005147 substrate binding site [chemical binding]; other site 536056005148 catalytic residue [active] 536056005149 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 536056005150 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 536056005151 dimer interface [polypeptide binding]; other site 536056005152 active site 536056005153 metal binding site [ion binding]; metal-binding site 536056005154 glutathione binding site [chemical binding]; other site 536056005155 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 536056005156 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 536056005157 dimer interface [polypeptide binding]; other site 536056005158 catalytic site [active] 536056005159 putative active site [active] 536056005160 putative substrate binding site [chemical binding]; other site 536056005161 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 536056005162 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 536056005163 ATP binding site [chemical binding]; other site 536056005164 putative Mg++ binding site [ion binding]; other site 536056005165 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 536056005166 nucleotide binding region [chemical binding]; other site 536056005167 ATP-binding site [chemical binding]; other site 536056005168 DEAD/H associated; Region: DEAD_assoc; pfam08494 536056005169 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 536056005170 putative GSH binding site [chemical binding]; other site 536056005171 catalytic residues [active] 536056005172 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 536056005173 NlpC/P60 family; Region: NLPC_P60; pfam00877 536056005174 superoxide dismutase; Provisional; Region: PRK10543 536056005175 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 536056005176 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 536056005177 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056005178 Major Facilitator Superfamily; Region: MFS_1; pfam07690 536056005179 putative substrate translocation pore; other site 536056005180 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 536056005181 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 536056005182 DNA binding site [nucleotide binding] 536056005183 domain linker motif; other site 536056005184 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 536056005185 dimerization interface [polypeptide binding]; other site 536056005186 ligand binding site [chemical binding]; other site 536056005187 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 536056005188 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056005189 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 536056005190 dimerization interface [polypeptide binding]; other site 536056005191 putative transporter; Provisional; Region: PRK11043 536056005192 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056005193 putative substrate translocation pore; other site 536056005194 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 536056005195 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 536056005196 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536056005197 S-adenosylmethionine binding site [chemical binding]; other site 536056005198 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 536056005199 Lumazine binding domain; Region: Lum_binding; pfam00677 536056005200 Lumazine binding domain; Region: Lum_binding; pfam00677 536056005201 Transposase domain (DUF772); Region: DUF772; pfam05598 536056005202 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 536056005203 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 536056005204 multidrug efflux protein; Reviewed; Region: PRK01766 536056005205 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 536056005206 cation binding site [ion binding]; other site 536056005207 hypothetical protein; Provisional; Region: PRK09945 536056005208 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 536056005209 putative monooxygenase; Provisional; Region: PRK11118 536056005210 hypothetical protein; Provisional; Region: PRK09897 536056005211 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 536056005212 hypothetical protein; Provisional; Region: PRK09946 536056005213 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 536056005214 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 536056005215 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 536056005216 hypothetical protein; Provisional; Region: PRK09947 536056005217 putative oxidoreductase; Provisional; Region: PRK09849 536056005218 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 536056005219 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 536056005220 hypothetical protein; Provisional; Region: PRK09898 536056005221 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 536056005222 hypothetical protein; Provisional; Region: PRK10292 536056005223 pyruvate kinase; Provisional; Region: PRK09206 536056005224 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 536056005225 domain interfaces; other site 536056005226 active site 536056005227 murein lipoprotein; Provisional; Region: PRK15396 536056005228 L,D-transpeptidase; Provisional; Region: PRK10190 536056005229 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 536056005230 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 536056005231 cysteine desufuration protein SufE; Provisional; Region: PRK09296 536056005232 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 536056005233 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 536056005234 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 536056005235 catalytic residue [active] 536056005236 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 536056005237 FeS assembly protein SufD; Region: sufD; TIGR01981 536056005238 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 536056005239 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 536056005240 Walker A/P-loop; other site 536056005241 ATP binding site [chemical binding]; other site 536056005242 Q-loop/lid; other site 536056005243 ABC transporter signature motif; other site 536056005244 Walker B; other site 536056005245 D-loop; other site 536056005246 H-loop/switch region; other site 536056005247 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 536056005248 putative ABC transporter; Region: ycf24; CHL00085 536056005249 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 536056005250 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 536056005251 CoenzymeA binding site [chemical binding]; other site 536056005252 subunit interaction site [polypeptide binding]; other site 536056005253 PHB binding site; other site 536056005254 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 536056005255 FAD binding domain; Region: FAD_binding_4; pfam01565 536056005256 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 536056005257 putative inner membrane protein; Provisional; Region: PRK10983 536056005258 Domain of unknown function DUF20; Region: UPF0118; pfam01594 536056005259 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 536056005260 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056005261 Major Facilitator Superfamily; Region: MFS_1; pfam07690 536056005262 putative substrate translocation pore; other site 536056005263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056005264 putative substrate translocation pore; other site 536056005265 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 536056005266 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 536056005267 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 536056005268 shikimate binding site; other site 536056005269 NAD(P) binding site [chemical binding]; other site 536056005270 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 536056005271 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 536056005272 active site 536056005273 catalytic residue [active] 536056005274 dimer interface [polypeptide binding]; other site 536056005275 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 536056005276 Coenzyme A transferase; Region: CoA_trans; smart00882 536056005277 Coenzyme A transferase; Region: CoA_trans; cl17247 536056005278 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 536056005279 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 536056005280 active site 536056005281 Cupin domain; Region: Cupin_2; pfam07883 536056005282 Winged helix DNA-binding domain (DUF1495); Region: DUF1495; cl01336 536056005283 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 536056005284 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536056005285 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 536056005286 Ligand binding site [chemical binding]; other site 536056005287 Electron transfer flavoprotein domain; Region: ETF; pfam01012 536056005288 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 536056005289 Electron transfer flavoprotein domain; Region: ETF; smart00893 536056005290 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 536056005291 oxidoreductase; Provisional; Region: PRK10015 536056005292 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 536056005293 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 536056005294 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 536056005295 acyl-activating enzyme (AAE) consensus motif; other site 536056005296 putative AMP binding site [chemical binding]; other site 536056005297 putative active site [active] 536056005298 putative CoA binding site [chemical binding]; other site 536056005299 phosphoenolpyruvate synthase; Validated; Region: PRK06464 536056005300 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 536056005301 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 536056005302 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 536056005303 PEP synthetase regulatory protein; Provisional; Region: PRK05339 536056005304 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 536056005305 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 536056005306 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 536056005307 Uncharacterized conserved protein [Function unknown]; Region: COG0397 536056005308 hypothetical protein; Validated; Region: PRK00029 536056005309 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 536056005310 NlpC/P60 family; Region: NLPC_P60; pfam00877 536056005311 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 536056005312 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 536056005313 Walker A/P-loop; other site 536056005314 ATP binding site [chemical binding]; other site 536056005315 Q-loop/lid; other site 536056005316 ABC transporter signature motif; other site 536056005317 Walker B; other site 536056005318 D-loop; other site 536056005319 H-loop/switch region; other site 536056005320 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 536056005321 catalytic residues [active] 536056005322 dimer interface [polypeptide binding]; other site 536056005323 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 536056005324 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 536056005325 ABC-ATPase subunit interface; other site 536056005326 dimer interface [polypeptide binding]; other site 536056005327 putative PBP binding regions; other site 536056005328 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 536056005329 IHF dimer interface [polypeptide binding]; other site 536056005330 IHF - DNA interface [nucleotide binding]; other site 536056005331 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 536056005332 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 536056005333 putative tRNA-binding site [nucleotide binding]; other site 536056005334 B3/4 domain; Region: B3_4; pfam03483 536056005335 tRNA synthetase B5 domain; Region: B5; smart00874 536056005336 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 536056005337 dimer interface [polypeptide binding]; other site 536056005338 motif 1; other site 536056005339 motif 3; other site 536056005340 motif 2; other site 536056005341 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 536056005342 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 536056005343 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 536056005344 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 536056005345 dimer interface [polypeptide binding]; other site 536056005346 motif 1; other site 536056005347 active site 536056005348 motif 2; other site 536056005349 motif 3; other site 536056005350 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 536056005351 23S rRNA binding site [nucleotide binding]; other site 536056005352 L21 binding site [polypeptide binding]; other site 536056005353 L13 binding site [polypeptide binding]; other site 536056005354 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 536056005355 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 536056005356 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 536056005357 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 536056005358 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 536056005359 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 536056005360 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 536056005361 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 536056005362 active site 536056005363 dimer interface [polypeptide binding]; other site 536056005364 motif 1; other site 536056005365 motif 2; other site 536056005366 motif 3; other site 536056005367 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 536056005368 anticodon binding site; other site 536056005369 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 536056005370 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 536056005371 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 536056005372 6-phosphofructokinase 2; Provisional; Region: PRK10294 536056005373 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 536056005374 putative substrate binding site [chemical binding]; other site 536056005375 putative ATP binding site [chemical binding]; other site 536056005376 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 536056005377 Phosphotransferase enzyme family; Region: APH; pfam01636 536056005378 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 536056005379 active site 536056005380 ATP binding site [chemical binding]; other site 536056005381 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 536056005382 YniB-like protein; Region: YniB; pfam14002 536056005383 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 536056005384 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 536056005385 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536056005386 motif II; other site 536056005387 inner membrane protein; Provisional; Region: PRK11648 536056005388 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 536056005389 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 536056005390 cell division modulator; Provisional; Region: PRK10113 536056005391 hydroperoxidase II; Provisional; Region: katE; PRK11249 536056005392 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 536056005393 tetramer interface [polypeptide binding]; other site 536056005394 heme binding pocket [chemical binding]; other site 536056005395 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 536056005396 domain interactions; other site 536056005397 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 536056005398 putative active site [active] 536056005399 YdjC motif; other site 536056005400 Mg binding site [ion binding]; other site 536056005401 putative homodimer interface [polypeptide binding]; other site 536056005402 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 536056005403 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 536056005404 NAD binding site [chemical binding]; other site 536056005405 sugar binding site [chemical binding]; other site 536056005406 divalent metal binding site [ion binding]; other site 536056005407 tetramer (dimer of dimers) interface [polypeptide binding]; other site 536056005408 dimer interface [polypeptide binding]; other site 536056005409 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 536056005410 Cupin domain; Region: Cupin_2; pfam07883 536056005411 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536056005412 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 536056005413 methionine cluster; other site 536056005414 active site 536056005415 phosphorylation site [posttranslational modification] 536056005416 metal binding site [ion binding]; metal-binding site 536056005417 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 536056005418 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 536056005419 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 536056005420 active site 536056005421 P-loop; other site 536056005422 phosphorylation site [posttranslational modification] 536056005423 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 536056005424 NAD+ synthetase; Region: nadE; TIGR00552 536056005425 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 536056005426 homodimer interface [polypeptide binding]; other site 536056005427 NAD binding pocket [chemical binding]; other site 536056005428 ATP binding pocket [chemical binding]; other site 536056005429 Mg binding site [ion binding]; other site 536056005430 active-site loop [active] 536056005431 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 536056005432 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 536056005433 GIY-YIG motif/motif A; other site 536056005434 active site 536056005435 catalytic site [active] 536056005436 putative DNA binding site [nucleotide binding]; other site 536056005437 metal binding site [ion binding]; metal-binding site 536056005438 hypothetical protein; Provisional; Region: PRK11396 536056005439 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 536056005440 dimer interface [polypeptide binding]; other site 536056005441 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 536056005442 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 536056005443 putative active site [active] 536056005444 Zn binding site [ion binding]; other site 536056005445 succinylarginine dihydrolase; Provisional; Region: PRK13281 536056005446 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 536056005447 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 536056005448 NAD(P) binding site [chemical binding]; other site 536056005449 catalytic residues [active] 536056005450 arginine succinyltransferase; Provisional; Region: PRK10456 536056005451 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 536056005452 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 536056005453 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 536056005454 inhibitor-cofactor binding pocket; inhibition site 536056005455 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056005456 catalytic residue [active] 536056005457 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 536056005458 putative catalytic site [active] 536056005459 putative phosphate binding site [ion binding]; other site 536056005460 active site 536056005461 metal binding site A [ion binding]; metal-binding site 536056005462 DNA binding site [nucleotide binding] 536056005463 putative AP binding site [nucleotide binding]; other site 536056005464 putative metal binding site B [ion binding]; other site 536056005465 Uncharacterized conserved protein [Function unknown]; Region: COG0398 536056005466 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 536056005467 Uncharacterized conserved protein [Function unknown]; Region: COG0398 536056005468 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 536056005469 Uncharacterized conserved protein [Function unknown]; Region: COG2128 536056005470 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 536056005471 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 536056005472 hypothetical protein; Provisional; Region: PRK11622 536056005473 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 536056005474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056005475 dimer interface [polypeptide binding]; other site 536056005476 conserved gate region; other site 536056005477 putative PBP binding loops; other site 536056005478 ABC-ATPase subunit interface; other site 536056005479 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 536056005480 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536056005481 Walker A/P-loop; other site 536056005482 ATP binding site [chemical binding]; other site 536056005483 Q-loop/lid; other site 536056005484 ABC transporter signature motif; other site 536056005485 Walker B; other site 536056005486 D-loop; other site 536056005487 H-loop/switch region; other site 536056005488 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 536056005489 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 536056005490 active site residue [active] 536056005491 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 536056005492 active site residue [active] 536056005493 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 536056005494 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 536056005495 active site 536056005496 8-oxo-dGMP binding site [chemical binding]; other site 536056005497 nudix motif; other site 536056005498 metal binding site [ion binding]; metal-binding site 536056005499 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 536056005500 glutamate dehydrogenase; Provisional; Region: PRK09414 536056005501 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 536056005502 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 536056005503 NAD(P) binding site [chemical binding]; other site 536056005504 hypothetical protein; Provisional; Region: PRK11380 536056005505 DNA topoisomerase III; Provisional; Region: PRK07726 536056005506 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 536056005507 active site 536056005508 putative interdomain interaction site [polypeptide binding]; other site 536056005509 putative metal-binding site [ion binding]; other site 536056005510 putative nucleotide binding site [chemical binding]; other site 536056005511 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 536056005512 domain I; other site 536056005513 DNA binding groove [nucleotide binding] 536056005514 phosphate binding site [ion binding]; other site 536056005515 domain II; other site 536056005516 domain III; other site 536056005517 nucleotide binding site [chemical binding]; other site 536056005518 catalytic site [active] 536056005519 domain IV; other site 536056005520 selenophosphate synthetase; Provisional; Region: PRK00943 536056005521 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 536056005522 dimerization interface [polypeptide binding]; other site 536056005523 putative ATP binding site [chemical binding]; other site 536056005524 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 536056005525 putative FMN binding site [chemical binding]; other site 536056005526 protease 4; Provisional; Region: PRK10949 536056005527 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 536056005528 tandem repeat interface [polypeptide binding]; other site 536056005529 oligomer interface [polypeptide binding]; other site 536056005530 active site residues [active] 536056005531 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 536056005532 tandem repeat interface [polypeptide binding]; other site 536056005533 oligomer interface [polypeptide binding]; other site 536056005534 active site residues [active] 536056005535 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 536056005536 active site 536056005537 homodimer interface [polypeptide binding]; other site 536056005538 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 536056005539 Isochorismatase family; Region: Isochorismatase; pfam00857 536056005540 catalytic triad [active] 536056005541 metal binding site [ion binding]; metal-binding site 536056005542 conserved cis-peptide bond; other site 536056005543 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 536056005544 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056005545 putative substrate translocation pore; other site 536056005546 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056005547 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 536056005548 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 536056005549 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 536056005550 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 536056005551 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 536056005552 active site 536056005553 catalytic tetrad [active] 536056005554 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 536056005555 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 536056005556 substrate binding site [chemical binding]; other site 536056005557 ATP binding site [chemical binding]; other site 536056005558 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 536056005559 intersubunit interface [polypeptide binding]; other site 536056005560 active site 536056005561 zinc binding site [ion binding]; other site 536056005562 Na+ binding site [ion binding]; other site 536056005563 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 536056005564 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 536056005565 inhibitor binding site; inhibition site 536056005566 catalytic Zn binding site [ion binding]; other site 536056005567 structural Zn binding site [ion binding]; other site 536056005568 NADP binding site [chemical binding]; other site 536056005569 tetramer interface [polypeptide binding]; other site 536056005570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056005571 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056005572 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 536056005573 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 536056005574 putative NAD(P) binding site [chemical binding]; other site 536056005575 catalytic Zn binding site [ion binding]; other site 536056005576 structural Zn binding site [ion binding]; other site 536056005577 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 536056005578 methionine sulfoxide reductase B; Provisional; Region: PRK00222 536056005579 SelR domain; Region: SelR; pfam01641 536056005580 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 536056005581 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 536056005582 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 536056005583 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 536056005584 active site 536056005585 phosphate binding residues; other site 536056005586 catalytic residues [active] 536056005587 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 536056005588 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 536056005589 active site 536056005590 catalytic tetrad [active] 536056005591 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 536056005592 PrkA family serine protein kinase; Provisional; Region: PRK15455 536056005593 AAA ATPase domain; Region: AAA_16; pfam13191 536056005594 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 536056005595 hypothetical protein; Provisional; Region: PRK05325 536056005596 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 536056005597 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 536056005598 metal binding site [ion binding]; metal-binding site 536056005599 active site 536056005600 I-site; other site 536056005601 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 536056005602 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 536056005603 metal binding site [ion binding]; metal-binding site 536056005604 active site 536056005605 I-site; other site 536056005606 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 536056005607 putative deacylase active site [active] 536056005608 Predicted membrane protein [Function unknown]; Region: COG2707 536056005609 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 536056005610 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536056005611 cyanate transporter; Region: CynX; TIGR00896 536056005612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056005613 Uncharacterized conserved protein [Function unknown]; Region: COG3189 536056005614 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 536056005615 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 536056005616 Domain of unknown function (DUF333); Region: DUF333; pfam03891 536056005617 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 536056005618 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 536056005619 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 536056005620 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 536056005621 metal binding site [ion binding]; metal-binding site 536056005622 active site 536056005623 I-site; other site 536056005624 hypothetical protein; Provisional; Region: PRK10457 536056005625 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 536056005626 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 536056005627 leucine export protein LeuE; Provisional; Region: PRK10958 536056005628 transcriptional activator TtdR; Provisional; Region: PRK09801 536056005629 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056005630 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 536056005631 putative effector binding pocket; other site 536056005632 putative dimerization interface [polypeptide binding]; other site 536056005633 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 536056005634 tartrate dehydrogenase; Region: TTC; TIGR02089 536056005635 putative transporter; Provisional; Region: PRK09950 536056005636 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 536056005637 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 536056005638 [2Fe-2S] cluster binding site [ion binding]; other site 536056005639 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886 536056005640 putative alpha subunit interface [polypeptide binding]; other site 536056005641 putative active site [active] 536056005642 putative substrate binding site [chemical binding]; other site 536056005643 Fe binding site [ion binding]; other site 536056005644 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 536056005645 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 536056005646 FMN-binding pocket [chemical binding]; other site 536056005647 flavin binding motif; other site 536056005648 phosphate binding motif [ion binding]; other site 536056005649 beta-alpha-beta structure motif; other site 536056005650 NAD binding pocket [chemical binding]; other site 536056005651 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 536056005652 catalytic loop [active] 536056005653 iron binding site [ion binding]; other site 536056005654 ribonuclease D; Provisional; Region: PRK10829 536056005655 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 536056005656 catalytic site [active] 536056005657 putative active site [active] 536056005658 putative substrate binding site [chemical binding]; other site 536056005659 Helicase and RNase D C-terminal; Region: HRDC; smart00341 536056005660 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 536056005661 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 536056005662 acyl-activating enzyme (AAE) consensus motif; other site 536056005663 putative AMP binding site [chemical binding]; other site 536056005664 putative active site [active] 536056005665 putative CoA binding site [chemical binding]; other site 536056005666 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 536056005667 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 536056005668 Glycoprotease family; Region: Peptidase_M22; pfam00814 536056005669 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 536056005670 DEAD/DEAH box helicase; Region: DEAD; pfam00270 536056005671 DEAD_2; Region: DEAD_2; pfam06733 536056005672 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 536056005673 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 536056005674 homotrimer interaction site [polypeptide binding]; other site 536056005675 putative active site [active] 536056005676 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 536056005677 hypothetical protein; Provisional; Region: PRK05114 536056005678 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 536056005679 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 536056005680 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 536056005681 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 536056005682 putative active site [active] 536056005683 putative CoA binding site [chemical binding]; other site 536056005684 nudix motif; other site 536056005685 metal binding site [ion binding]; metal-binding site 536056005686 L-serine deaminase; Provisional; Region: PRK15023 536056005687 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 536056005688 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 536056005689 phage resistance protein; Provisional; Region: PRK10551 536056005690 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 536056005691 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 536056005692 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 536056005693 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 536056005694 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 536056005695 Transporter associated domain; Region: CorC_HlyC; smart01091 536056005696 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 536056005697 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 536056005698 active pocket/dimerization site; other site 536056005699 active site 536056005700 phosphorylation site [posttranslational modification] 536056005701 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 536056005702 active site 536056005703 phosphorylation site [posttranslational modification] 536056005704 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 536056005705 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 536056005706 Predicted membrane protein [Function unknown]; Region: COG4811 536056005707 hypothetical protein; Provisional; Region: PRK11469 536056005708 Domain of unknown function DUF; Region: DUF204; pfam02659 536056005709 Domain of unknown function DUF; Region: DUF204; pfam02659 536056005710 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 536056005711 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536056005712 S-adenosylmethionine binding site [chemical binding]; other site 536056005713 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 536056005714 DNA-binding site [nucleotide binding]; DNA binding site 536056005715 RNA-binding motif; other site 536056005716 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 536056005717 YebO-like protein; Region: YebO; pfam13974 536056005718 PhoPQ regulatory protein; Provisional; Region: PRK10299 536056005719 YobH-like protein; Region: YobH; pfam13996 536056005720 'predicted DNA-binding transcriptional regulator, pseudogene fragment due to insertion' 536056005721 Transposase domain (DUF772); Region: DUF772; pfam05598 536056005722 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 536056005723 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 536056005724 'predicted DNA-binding transcriptional regulator, pseudogene fragment due to insertion' 536056005725 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056005726 Major Facilitator Superfamily; Region: MFS_1; pfam07690 536056005727 putative substrate translocation pore; other site 536056005728 Predicted integral membrane protein [Function unknown]; Region: COG5521 536056005729 heat shock protein HtpX; Provisional; Region: PRK05457 536056005730 carboxy-terminal protease; Provisional; Region: PRK11186 536056005731 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 536056005732 protein binding site [polypeptide binding]; other site 536056005733 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 536056005734 Catalytic dyad [active] 536056005735 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 536056005736 ProP expression regulator; Provisional; Region: PRK04950 536056005737 ProQ/FINO family; Region: ProQ; pfam04352 536056005738 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 536056005739 GAF domain; Region: GAF_2; pfam13185 536056005740 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 536056005741 Paraquat-inducible protein A; Region: PqiA; pfam04403 536056005742 Paraquat-inducible protein A; Region: PqiA; pfam04403 536056005743 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 536056005744 mce related protein; Region: MCE; pfam02470 536056005745 mce related protein; Region: MCE; pfam02470 536056005746 mce related protein; Region: MCE; pfam02470 536056005747 mce related protein; Region: MCE; pfam02470 536056005748 mce related protein; Region: MCE; pfam02470 536056005749 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 536056005750 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536056005751 S-adenosylmethionine binding site [chemical binding]; other site 536056005752 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 536056005753 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 536056005754 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 536056005755 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 536056005756 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 536056005757 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 536056005758 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 536056005759 hypothetical protein; Provisional; Region: PRK10301 536056005760 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 536056005761 Predicted amidohydrolase [General function prediction only]; Region: COG0388 536056005762 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 536056005763 exodeoxyribonuclease X; Provisional; Region: PRK07983 536056005764 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 536056005765 active site 536056005766 catalytic site [active] 536056005767 substrate binding site [chemical binding]; other site 536056005768 protease 2; Provisional; Region: PRK10115 536056005769 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 536056005770 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 536056005771 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 536056005772 putative metal binding site [ion binding]; other site 536056005773 hypothetical protein; Provisional; Region: PRK13680 536056005774 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 536056005775 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 536056005776 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536056005777 ATP-grasp domain; Region: ATP-grasp; pfam02222 536056005778 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 536056005779 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 536056005780 active site 536056005781 intersubunit interface [polypeptide binding]; other site 536056005782 catalytic residue [active] 536056005783 phosphogluconate dehydratase; Validated; Region: PRK09054 536056005784 6-phosphogluconate dehydratase; Region: edd; TIGR01196 536056005785 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 536056005786 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 536056005787 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 536056005788 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 536056005789 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 536056005790 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 536056005791 putative active site [active] 536056005792 pyruvate kinase; Provisional; Region: PRK05826 536056005793 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 536056005794 domain interfaces; other site 536056005795 active site 536056005796 'function: Lauroyl/myristoyl acyltransferase; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVAacyl transferase, frameshift due to single base deletion' 536056005797 putative peptidase; Provisional; Region: PRK11649 536056005798 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 536056005799 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 536056005800 Peptidase family M23; Region: Peptidase_M23; pfam01551 536056005801 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 536056005802 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 536056005803 metal binding site [ion binding]; metal-binding site 536056005804 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 536056005805 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 536056005806 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 536056005807 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 536056005808 ABC-ATPase subunit interface; other site 536056005809 dimer interface [polypeptide binding]; other site 536056005810 putative PBP binding regions; other site 536056005811 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 536056005812 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536056005813 Walker A motif; other site 536056005814 ATP binding site [chemical binding]; other site 536056005815 Walker B motif; other site 536056005816 arginine finger; other site 536056005817 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 536056005818 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 536056005819 RuvA N terminal domain; Region: RuvA_N; pfam01330 536056005820 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 536056005821 hypothetical protein; Provisional; Region: PRK11470 536056005822 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 536056005823 active site 536056005824 putative DNA-binding cleft [nucleotide binding]; other site 536056005825 dimer interface [polypeptide binding]; other site 536056005826 hypothetical protein; Validated; Region: PRK00110 536056005827 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 536056005828 nudix motif; other site 536056005829 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 536056005830 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 536056005831 dimer interface [polypeptide binding]; other site 536056005832 anticodon binding site; other site 536056005833 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 536056005834 homodimer interface [polypeptide binding]; other site 536056005835 motif 1; other site 536056005836 active site 536056005837 motif 2; other site 536056005838 GAD domain; Region: GAD; pfam02938 536056005839 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 536056005840 motif 3; other site 536056005841 Isochorismatase family; Region: Isochorismatase; pfam00857 536056005842 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 536056005843 catalytic triad [active] 536056005844 conserved cis-peptide bond; other site 536056005845 hypothetical protein; Provisional; Region: PRK10302 536056005846 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 536056005847 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536056005848 S-adenosylmethionine binding site [chemical binding]; other site 536056005849 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536056005850 S-adenosylmethionine binding site [chemical binding]; other site 536056005851 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 536056005852 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 536056005853 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 536056005854 molybdopterin cofactor binding site [chemical binding]; other site 536056005855 substrate binding site [chemical binding]; other site 536056005856 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 536056005857 molybdopterin cofactor binding site; other site 536056005858 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 536056005859 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 536056005860 copper homeostasis protein CutC; Provisional; Region: PRK11572 536056005861 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 536056005862 putative metal binding site [ion binding]; other site 536056005863 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 536056005864 arginyl-tRNA synthetase; Region: argS; TIGR00456 536056005865 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 536056005866 active site 536056005867 HIGH motif; other site 536056005868 KMSK motif region; other site 536056005869 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 536056005870 tRNA binding surface [nucleotide binding]; other site 536056005871 anticodon binding site; other site 536056005872 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 536056005873 Flagellar protein FlhE; Region: FlhE; pfam06366 536056005874 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 536056005875 FHIPEP family; Region: FHIPEP; pfam00771 536056005876 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 536056005877 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 536056005878 chemotaxis regulator CheZ; Provisional; Region: PRK11166 536056005879 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 536056005880 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536056005881 active site 536056005882 phosphorylation site [posttranslational modification] 536056005883 intermolecular recognition site; other site 536056005884 dimerization interface [polypeptide binding]; other site 536056005885 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 536056005886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536056005887 active site 536056005888 phosphorylation site [posttranslational modification] 536056005889 intermolecular recognition site; other site 536056005890 dimerization interface [polypeptide binding]; other site 536056005891 CheB methylesterase; Region: CheB_methylest; pfam01339 536056005892 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 536056005893 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 536056005894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536056005895 S-adenosylmethionine binding site [chemical binding]; other site 536056005896 methyl-accepting protein IV; Provisional; Region: PRK09793 536056005897 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 536056005898 dimer interface [polypeptide binding]; other site 536056005899 ligand binding site [chemical binding]; other site 536056005900 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 536056005901 dimerization interface [polypeptide binding]; other site 536056005902 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 536056005903 dimer interface [polypeptide binding]; other site 536056005904 putative CheW interface [polypeptide binding]; other site 536056005905 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 536056005906 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 536056005907 dimer interface [polypeptide binding]; other site 536056005908 ligand binding site [chemical binding]; other site 536056005909 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 536056005910 dimerization interface [polypeptide binding]; other site 536056005911 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 536056005912 dimer interface [polypeptide binding]; other site 536056005913 putative CheW interface [polypeptide binding]; other site 536056005914 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 536056005915 putative CheA interaction surface; other site 536056005916 chemotaxis protein CheA; Provisional; Region: PRK10547 536056005917 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 536056005918 putative binding surface; other site 536056005919 active site 536056005920 CheY binding; Region: CheY-binding; pfam09078 536056005921 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 536056005922 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536056005923 ATP binding site [chemical binding]; other site 536056005924 Mg2+ binding site [ion binding]; other site 536056005925 G-X-G motif; other site 536056005926 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 536056005927 flagellar motor protein MotB; Validated; Region: motB; PRK09041 536056005928 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 536056005929 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 536056005930 ligand binding site [chemical binding]; other site 536056005931 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 536056005932 flagellar motor protein MotA; Validated; Region: PRK09110 536056005933 transcriptional activator FlhC; Provisional; Region: PRK12722 536056005934 transcriptional activator FlhD; Provisional; Region: PRK02909 536056005935 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 536056005936 Ligand Binding Site [chemical binding]; other site 536056005937 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 536056005938 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 536056005939 active site 536056005940 homotetramer interface [polypeptide binding]; other site 536056005941 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 536056005942 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 536056005943 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536056005944 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536056005945 TM-ABC transporter signature motif; other site 536056005946 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 536056005947 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536056005948 Walker A/P-loop; other site 536056005949 ATP binding site [chemical binding]; other site 536056005950 Q-loop/lid; other site 536056005951 ABC transporter signature motif; other site 536056005952 Walker B; other site 536056005953 D-loop; other site 536056005954 H-loop/switch region; other site 536056005955 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 536056005956 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 536056005957 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 536056005958 ligand binding site [chemical binding]; other site 536056005959 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 536056005960 Ferritin-like domain; Region: Ferritin; pfam00210 536056005961 ferroxidase diiron center [ion binding]; other site 536056005962 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 536056005963 YecR-like lipoprotein; Region: YecR; pfam13992 536056005964 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 536056005965 Ferritin-like domain; Region: Ferritin; pfam00210 536056005966 ferroxidase diiron center [ion binding]; other site 536056005967 probable metal-binding protein; Region: matur_matur; TIGR03853 536056005968 tyrosine transporter TyrP; Provisional; Region: PRK15132 536056005969 aromatic amino acid transport protein; Region: araaP; TIGR00837 536056005970 hypothetical protein; Provisional; Region: PRK10396 536056005971 yecA family protein; Region: ygfB_yecA; TIGR02292 536056005972 SEC-C motif; Region: SEC-C; pfam02810 536056005973 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 536056005974 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 536056005975 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 536056005976 GIY-YIG motif/motif A; other site 536056005977 active site 536056005978 catalytic site [active] 536056005979 putative DNA binding site [nucleotide binding]; other site 536056005980 metal binding site [ion binding]; metal-binding site 536056005981 UvrB/uvrC motif; Region: UVR; pfam02151 536056005982 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 536056005983 Helix-hairpin-helix motif; Region: HHH; pfam00633 536056005984 response regulator; Provisional; Region: PRK09483 536056005985 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536056005986 active site 536056005987 phosphorylation site [posttranslational modification] 536056005988 intermolecular recognition site; other site 536056005989 dimerization interface [polypeptide binding]; other site 536056005990 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536056005991 DNA binding residues [nucleotide binding] 536056005992 dimerization interface [polypeptide binding]; other site 536056005993 hypothetical protein; Provisional; Region: PRK10613 536056005994 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 536056005995 Autoinducer binding domain; Region: Autoind_bind; pfam03472 536056005996 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536056005997 DNA binding residues [nucleotide binding] 536056005998 dimerization interface [polypeptide binding]; other site 536056005999 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 536056006000 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 536056006001 Walker A/P-loop; other site 536056006002 ATP binding site [chemical binding]; other site 536056006003 Q-loop/lid; other site 536056006004 ABC transporter signature motif; other site 536056006005 Walker B; other site 536056006006 D-loop; other site 536056006007 H-loop/switch region; other site 536056006008 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 536056006009 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056006010 dimer interface [polypeptide binding]; other site 536056006011 conserved gate region; other site 536056006012 putative PBP binding loops; other site 536056006013 ABC-ATPase subunit interface; other site 536056006014 D-cysteine desulfhydrase; Validated; Region: PRK03910 536056006015 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 536056006016 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056006017 catalytic residue [active] 536056006018 cystine transporter subunit; Provisional; Region: PRK11260 536056006019 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536056006020 substrate binding pocket [chemical binding]; other site 536056006021 membrane-bound complex binding site; other site 536056006022 hinge residues; other site 536056006023 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 536056006024 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 536056006025 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 536056006026 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 536056006027 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 536056006028 DNA binding residues [nucleotide binding] 536056006029 flagellin; Validated; Region: PRK08026 536056006030 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 536056006031 Flagellin D3 domain; Region: Flagellin_D3; pfam08884 536056006032 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 536056006033 flagellar capping protein; Reviewed; Region: fliD; PRK08032 536056006034 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 536056006035 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 536056006036 flagellar biosynthetic protein FliS; Region: fliS; TIGR00208 536056006037 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 536056006038 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 536056006039 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 536056006040 active site 536056006041 Na/Ca binding site [ion binding]; other site 536056006042 catalytic site [active] 536056006043 lipoprotein; Provisional; Region: PRK10397 536056006044 putative inner membrane protein; Provisional; Region: PRK11099 536056006045 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 536056006046 CPxP motif; other site 536056006047 hypothetical protein; Provisional; Region: PRK09951 536056006048 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 536056006049 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536056006050 Coenzyme A binding pocket [chemical binding]; other site 536056006051 potential frameshift: common BLAST hit: gi|254793586|ref|YP_003078423.1| non-LEE-encoded type III effector 536056006052 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 536056006053 potential frameshift: common BLAST hit: gi|254793584|ref|YP_003078421.1| non-LEE-encoded type III effector 536056006054 E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387 536056006055 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 536056006056 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 536056006057 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 536056006058 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 536056006059 flagellar motor switch protein FliG; Region: fliG; TIGR00207 536056006060 FliG C-terminal domain; Region: FliG_C; pfam01706 536056006061 flagellar assembly protein H; Validated; Region: fliH; PRK05687 536056006062 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 536056006063 Flagellar assembly protein FliH; Region: FliH; pfam02108 536056006064 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 536056006065 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 536056006066 Walker A motif/ATP binding site; other site 536056006067 Walker B motif; other site 536056006068 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 536056006069 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 536056006070 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 536056006071 flagellar hook-length control protein; Provisional; Region: PRK10118 536056006072 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 536056006073 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 536056006074 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 536056006075 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 536056006076 flagellar motor switch protein; Validated; Region: fliN; PRK05698 536056006077 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 536056006078 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 536056006079 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 536056006080 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 536056006081 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 536056006082 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536056006083 DNA binding residues [nucleotide binding] 536056006084 dimerization interface [polypeptide binding]; other site 536056006085 hypothetical protein; Provisional; Region: PRK10708 536056006086 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 536056006087 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 536056006088 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536056006089 active site 536056006090 motif I; other site 536056006091 motif II; other site 536056006092 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 536056006093 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 536056006094 metal binding site [ion binding]; metal-binding site 536056006095 active site 536056006096 I-site; other site 536056006097 Uncharacterized small protein [Function unknown]; Region: COG5475 536056006098 hypothetical protein; Provisional; Region: PRK10062 536056006099 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 536056006100 EamA-like transporter family; Region: EamA; pfam00892 536056006101 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 536056006102 additional DNA contacts [nucleotide binding]; other site 536056006103 mismatch recognition site; other site 536056006104 active site 536056006105 zinc binding site [ion binding]; other site 536056006106 DNA intercalation site [nucleotide binding]; other site 536056006107 DNA cytosine methylase; Provisional; Region: PRK10458 536056006108 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 536056006109 cofactor binding site; other site 536056006110 DNA binding site [nucleotide binding] 536056006111 substrate interaction site [chemical binding]; other site 536056006112 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 536056006113 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 536056006114 Zn2+ binding site [ion binding]; other site 536056006115 Mg2+ binding site [ion binding]; other site 536056006116 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 536056006117 potential frameshift: common BLAST hit: gi|218705457|ref|YP_002412976.1| porin OmpN 536056006118 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 536056006119 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 536056006120 potential frameshift: common BLAST hit: gi|218705457|ref|YP_002412976.1| porin OmpN 536056006121 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 536056006122 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 536056006123 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 536056006124 chaperone protein HchA; Provisional; Region: PRK04155 536056006125 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 536056006126 dimer interface [polypeptide binding]; other site 536056006127 metal binding site [ion binding]; metal-binding site 536056006128 potential oxyanion hole; other site 536056006129 potential catalytic triad [active] 536056006130 conserved cys residue [active] 536056006131 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 536056006132 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536056006133 dimer interface [polypeptide binding]; other site 536056006134 phosphorylation site [posttranslational modification] 536056006135 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536056006136 ATP binding site [chemical binding]; other site 536056006137 Mg2+ binding site [ion binding]; other site 536056006138 G-X-G motif; other site 536056006139 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 536056006140 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536056006141 active site 536056006142 phosphorylation site [posttranslational modification] 536056006143 intermolecular recognition site; other site 536056006144 dimerization interface [polypeptide binding]; other site 536056006145 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 536056006146 DNA binding site [nucleotide binding] 536056006147 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 536056006148 active site 536056006149 homotetramer interface [polypeptide binding]; other site 536056006150 TMAO/DMSO reductase; Reviewed; Region: PRK05363 536056006151 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 536056006152 Moco binding site; other site 536056006153 metal coordination site [ion binding]; other site 536056006154 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 536056006155 zinc/cadmium-binding protein; Provisional; Region: PRK10306 536056006156 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 536056006157 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 536056006158 putative invasin; Provisional; Region: PRK10177 536056006159 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 536056006160 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 536056006161 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 536056006162 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 536056006163 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 536056006164 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 536056006165 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 536056006166 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 536056006167 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 536056006168 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 536056006169 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 536056006170 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 536056006171 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 536056006172 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 536056006173 potential frameshift: common BLAST hit: gi|383178936|ref|YP_005456941.1| glycosyl transferase family protein 536056006174 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 536056006175 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 536056006176 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 536056006177 shikimate transporter; Provisional; Region: PRK09952 536056006178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056006179 putative substrate translocation pore; other site 536056006180 AMP nucleosidase; Provisional; Region: PRK08292 536056006181 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 536056006182 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 536056006183 hypothetical protein; Provisional; Region: PRK12378 536056006184 MATE family multidrug exporter; Provisional; Region: PRK10189 536056006185 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 536056006186 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 536056006187 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056006188 The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444 536056006189 putative substrate binding site [chemical binding]; other site 536056006190 dimerization interface [polypeptide binding]; other site 536056006191 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 536056006192 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056006193 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 536056006194 putative dimerization interface [polypeptide binding]; other site 536056006195 L,D-transpeptidase; Provisional; Region: PRK10190 536056006196 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 536056006197 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 536056006198 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 536056006199 putative dimer interface [polypeptide binding]; other site 536056006200 active site pocket [active] 536056006201 putative cataytic base [active] 536056006202 cobalamin 5'-phosphate synthase/cobalamin synthase; Region: cobS; TIGR00317 536056006203 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 536056006204 homotrimer interface [polypeptide binding]; other site 536056006205 Walker A motif; other site 536056006206 GTP binding site [chemical binding]; other site 536056006207 Walker B motif; other site 536056006208 Transposase domain (DUF772); Region: DUF772; pfam05598 536056006209 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 536056006210 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 536056006211 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 536056006212 IS2 transposase TnpB; Reviewed; Region: PRK09409 536056006213 HTH-like domain; Region: HTH_21; pfam13276 536056006214 Integrase core domain; Region: rve; pfam00665 536056006215 Integrase core domain; Region: rve_3; pfam13683 536056006216 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 536056006217 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 536056006218 G4 box; other site 536056006219 G5 box; other site 536056006220 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 536056006221 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 536056006222 hypothetical protein; Provisional; Region: PRK09945 536056006223 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 536056006224 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 536056006225 Autotransporter beta-domain; Region: Autotransporter; smart00869 536056006226 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 536056006227 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 536056006228 MPN+ (JAMM) motif; other site 536056006229 Zinc-binding site [ion binding]; other site 536056006230 Protein of unknown function (DUF987); Region: DUF987; pfam06174 536056006231 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 536056006232 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 536056006233 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 536056006234 G4 box; other site 536056006235 G5 box; other site 536056006236 hypothetical protein; Provisional; Region: PRK05423 536056006237 Predicted membrane protein [Function unknown]; Region: COG1289 536056006238 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 536056006239 DNA gyrase inhibitor; Provisional; Region: PRK10016 536056006240 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 536056006241 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 536056006242 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 536056006243 exonuclease I; Provisional; Region: sbcB; PRK11779 536056006244 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 536056006245 active site 536056006246 catalytic site [active] 536056006247 substrate binding site [chemical binding]; other site 536056006248 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 536056006249 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 536056006250 CPxP motif; other site 536056006251 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 536056006252 Sulphur transport; Region: Sulf_transp; pfam04143 536056006253 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 536056006254 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056006255 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 536056006256 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 536056006257 dimerization interface [polypeptide binding]; other site 536056006258 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 536056006259 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 536056006260 putative NAD(P) binding site [chemical binding]; other site 536056006261 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 536056006262 antitoxin YefM; Provisional; Region: PRK11409 536056006263 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 536056006264 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 536056006265 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 536056006266 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 536056006267 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 536056006268 NAD binding site [chemical binding]; other site 536056006269 dimerization interface [polypeptide binding]; other site 536056006270 product binding site; other site 536056006271 substrate binding site [chemical binding]; other site 536056006272 zinc binding site [ion binding]; other site 536056006273 catalytic residues [active] 536056006274 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 536056006275 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 536056006276 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056006277 homodimer interface [polypeptide binding]; other site 536056006278 catalytic residue [active] 536056006279 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 536056006280 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536056006281 active site 536056006282 motif I; other site 536056006283 motif II; other site 536056006284 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 536056006285 putative active site pocket [active] 536056006286 4-fold oligomerization interface [polypeptide binding]; other site 536056006287 metal binding residues [ion binding]; metal-binding site 536056006288 3-fold/trimer interface [polypeptide binding]; other site 536056006289 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 536056006290 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 536056006291 putative active site [active] 536056006292 oxyanion strand; other site 536056006293 catalytic triad [active] 536056006294 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 536056006295 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 536056006296 catalytic residues [active] 536056006297 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 536056006298 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 536056006299 substrate binding site [chemical binding]; other site 536056006300 glutamase interaction surface [polypeptide binding]; other site 536056006301 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 536056006302 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 536056006303 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 536056006304 metal binding site [ion binding]; metal-binding site 536056006305 chain length determinant protein WzzB; Provisional; Region: PRK15471 536056006306 Chain length determinant protein; Region: Wzz; pfam02706 536056006307 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 536056006308 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 536056006309 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 536056006310 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 536056006311 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 536056006312 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 536056006313 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 536056006314 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 536056006315 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 536056006316 Transposase domain (DUF772); Region: DUF772; pfam05598 536056006317 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 536056006318 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 536056006319 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 536056006320 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 536056006321 active site 536056006322 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 536056006323 Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534 536056006324 putative lipopolysaccharide biosynthesis O-acetyl transferase WbbJ; Provisional; Region: PRK09677 536056006325 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 536056006326 trimer interface [polypeptide binding]; other site 536056006327 active site 536056006328 substrate binding site [chemical binding]; other site 536056006329 CoA binding site [chemical binding]; other site 536056006330 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 536056006331 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 536056006332 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 536056006333 UDP-galactopyranose mutase; Region: GLF; pfam03275 536056006334 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 536056006335 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 536056006336 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 536056006337 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 536056006338 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 536056006339 substrate binding site; other site 536056006340 tetramer interface; other site 536056006341 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 536056006342 NADP binding site [chemical binding]; other site 536056006343 active site 536056006344 putative substrate binding site [chemical binding]; other site 536056006345 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 536056006346 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 536056006347 NAD binding site [chemical binding]; other site 536056006348 substrate binding site [chemical binding]; other site 536056006349 homodimer interface [polypeptide binding]; other site 536056006350 active site 536056006351 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 536056006352 active site 536056006353 tetramer interface; other site 536056006354 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 536056006355 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 536056006356 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 536056006357 putative ADP-binding pocket [chemical binding]; other site 536056006358 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 536056006359 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 536056006360 colanic acid exporter; Provisional; Region: PRK10459 536056006361 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 536056006362 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 536056006363 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 536056006364 phosphomannomutase CpsG; Provisional; Region: PRK15414 536056006365 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 536056006366 active site 536056006367 substrate binding site [chemical binding]; other site 536056006368 metal binding site [ion binding]; metal-binding site 536056006369 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 536056006370 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 536056006371 Substrate binding site; other site 536056006372 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 536056006373 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 536056006374 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 536056006375 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 536056006376 active site 536056006377 GDP-Mannose binding site [chemical binding]; other site 536056006378 dimer interface [polypeptide binding]; other site 536056006379 modified nudix motif 536056006380 metal binding site [ion binding]; metal-binding site 536056006381 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 536056006382 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 536056006383 NADP binding site [chemical binding]; other site 536056006384 active site 536056006385 putative substrate binding site [chemical binding]; other site 536056006386 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 536056006387 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 536056006388 NADP-binding site; other site 536056006389 homotetramer interface [polypeptide binding]; other site 536056006390 substrate binding site [chemical binding]; other site 536056006391 homodimer interface [polypeptide binding]; other site 536056006392 active site 536056006393 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 536056006394 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 536056006395 putative trimer interface [polypeptide binding]; other site 536056006396 putative active site [active] 536056006397 putative substrate binding site [chemical binding]; other site 536056006398 putative CoA binding site [chemical binding]; other site 536056006399 putative glycosyl transferase; Provisional; Region: PRK10063 536056006400 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 536056006401 metal-binding site 536056006402 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 536056006403 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 536056006404 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 536056006405 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 536056006406 putative acyl transferase; Provisional; Region: PRK10191 536056006407 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 536056006408 trimer interface [polypeptide binding]; other site 536056006409 active site 536056006410 substrate binding site [chemical binding]; other site 536056006411 CoA binding site [chemical binding]; other site 536056006412 putative glycosyl transferase; Provisional; Region: PRK10018 536056006413 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 536056006414 active site 536056006415 tyrosine kinase; Provisional; Region: PRK11519 536056006416 Chain length determinant protein; Region: Wzz; pfam02706 536056006417 Chain length determinant protein; Region: Wzz; cl15801 536056006418 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 536056006419 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 536056006420 Low molecular weight phosphatase family; Region: LMWPc; cd00115 536056006421 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 536056006422 active site 536056006423 polysaccharide export protein Wza; Provisional; Region: PRK15078 536056006424 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 536056006425 SLBB domain; Region: SLBB; pfam10531 536056006426 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 536056006427 FOG: CBS domain [General function prediction only]; Region: COG0517 536056006428 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 536056006429 Transporter associated domain; Region: CorC_HlyC; smart01091 536056006430 putative assembly protein; Provisional; Region: PRK10833 536056006431 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 536056006432 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 536056006433 trimer interface [polypeptide binding]; other site 536056006434 active site 536056006435 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 536056006436 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 536056006437 ATP-binding site [chemical binding]; other site 536056006438 Sugar specificity; other site 536056006439 Pyrimidine base specificity; other site 536056006440 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 536056006441 putative diguanylate cyclase; Provisional; Region: PRK09776 536056006442 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536056006443 putative active site [active] 536056006444 heme pocket [chemical binding]; other site 536056006445 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536056006446 putative active site [active] 536056006447 heme pocket [chemical binding]; other site 536056006448 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536056006449 putative active site [active] 536056006450 heme pocket [chemical binding]; other site 536056006451 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 536056006452 metal binding site [ion binding]; metal-binding site 536056006453 active site 536056006454 I-site; other site 536056006455 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 536056006456 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 536056006457 AlkA N-terminal domain; Region: AlkA_N; smart01009 536056006458 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 536056006459 minor groove reading motif; other site 536056006460 helix-hairpin-helix signature motif; other site 536056006461 substrate binding pocket [chemical binding]; other site 536056006462 active site 536056006463 putative chaperone; Provisional; Region: PRK11678 536056006464 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 536056006465 nucleotide binding site [chemical binding]; other site 536056006466 putative NEF/HSP70 interaction site [polypeptide binding]; other site 536056006467 SBD interface [polypeptide binding]; other site 536056006468 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 536056006469 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 536056006470 substrate binding site [chemical binding]; other site 536056006471 activation loop (A-loop); other site 536056006472 Y-family of DNA polymerases; Region: PolY; cl12025 536056006473 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 536056006474 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077 536056006475 Protein phosphatase 2C; Region: PP2C_2; pfam13672 536056006476 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 536056006477 metal ion-dependent adhesion site (MIDAS); other site 536056006478 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 536056006479 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 536056006480 HlyD family secretion protein; Region: HlyD_3; pfam13437 536056006481 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 536056006482 Protein export membrane protein; Region: SecD_SecF; cl14618 536056006483 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 536056006484 putative transporter; Provisional; Region: PRK10504 536056006485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056006486 putative substrate translocation pore; other site 536056006487 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056006488 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 536056006489 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 536056006490 dimerization interface [polypeptide binding]; other site 536056006491 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536056006492 dimer interface [polypeptide binding]; other site 536056006493 phosphorylation site [posttranslational modification] 536056006494 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536056006495 ATP binding site [chemical binding]; other site 536056006496 Mg2+ binding site [ion binding]; other site 536056006497 G-X-G motif; other site 536056006498 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 536056006499 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536056006500 active site 536056006501 phosphorylation site [posttranslational modification] 536056006502 intermolecular recognition site; other site 536056006503 dimerization interface [polypeptide binding]; other site 536056006504 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 536056006505 DNA binding site [nucleotide binding] 536056006506 Uncharacterized conserved protein [Function unknown]; Region: COG3422 536056006507 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 536056006508 putative protease; Provisional; Region: PRK15452 536056006509 Peptidase family U32; Region: Peptidase_U32; pfam01136 536056006510 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 536056006511 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 536056006512 'predicted protein fragment (pseudogene), pseudogene fragment start codon change' 536056006513 lipid kinase; Reviewed; Region: PRK13054 536056006514 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 536056006515 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 536056006516 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 536056006517 Transposase; Region: HTH_Tnp_1; cl17663 536056006518 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 536056006519 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 536056006520 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 536056006521 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 536056006522 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 536056006523 putative NAD(P) binding site [chemical binding]; other site 536056006524 catalytic Zn binding site [ion binding]; other site 536056006525 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 536056006526 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 536056006527 Transposase domain (DUF772); Region: DUF772; pfam05598 536056006528 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 536056006529 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 536056006530 'galactitol-specific enzyme IIB component of PTS, missing stop codon due to insertion' 536056006531 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 536056006532 active site 536056006533 phosphorylation site [posttranslational modification] 536056006534 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 536056006535 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 536056006536 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 536056006537 intersubunit interface [polypeptide binding]; other site 536056006538 active site 536056006539 zinc binding site [ion binding]; other site 536056006540 Na+ binding site [ion binding]; other site 536056006541 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 536056006542 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 536056006543 putative active site; other site 536056006544 catalytic residue [active] 536056006545 nucleoside transporter; Region: 2A0110; TIGR00889 536056006546 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056006547 putative substrate translocation pore; other site 536056006548 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 536056006549 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 536056006550 YegV-like sugar kinase. Found only in bacteria, YegV-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YegV_kinase_like; cd01944 536056006551 substrate binding site [chemical binding]; other site 536056006552 ATP binding site [chemical binding]; other site 536056006553 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 536056006554 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536056006555 DNA-binding site [nucleotide binding]; DNA binding site 536056006556 UTRA domain; Region: UTRA; pfam07702 536056006557 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 536056006558 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 536056006559 active site 536056006560 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 536056006561 dimer interface [polypeptide binding]; other site 536056006562 substrate binding site [chemical binding]; other site 536056006563 ATP binding site [chemical binding]; other site 536056006564 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 536056006565 substrate binding site [chemical binding]; other site 536056006566 multimerization interface [polypeptide binding]; other site 536056006567 ATP binding site [chemical binding]; other site 536056006568 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 536056006569 putative metal binding site [ion binding]; other site 536056006570 putative homodimer interface [polypeptide binding]; other site 536056006571 putative homotetramer interface [polypeptide binding]; other site 536056006572 putative homodimer-homodimer interface [polypeptide binding]; other site 536056006573 putative allosteric switch controlling residues; other site 536056006574 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 536056006575 Predicted integral membrane protein [Function unknown]; Region: COG5455 536056006576 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 536056006577 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 536056006578 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 536056006579 PapC N-terminal domain; Region: PapC_N; pfam13954 536056006580 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 536056006581 PapC C-terminal domain; Region: PapC_C; pfam13953 536056006582 putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253 536056006583 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 536056006584 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 536056006585 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 536056006586 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 536056006587 antiporter inner membrane protein; Provisional; Region: PRK11670 536056006588 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 536056006589 Walker A motif; other site 536056006590 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 536056006591 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 536056006592 active site 536056006593 HIGH motif; other site 536056006594 KMSKS motif; other site 536056006595 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 536056006596 tRNA binding surface [nucleotide binding]; other site 536056006597 anticodon binding site; other site 536056006598 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 536056006599 dimer interface [polypeptide binding]; other site 536056006600 putative tRNA-binding site [nucleotide binding]; other site 536056006601 potential frameshift: common BLAST hit: gi|170019565|ref|YP_001724519.1| WGR domain-containing protein 536056006602 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 536056006603 potential frameshift: common BLAST hit: gi|170019565|ref|YP_001724519.1| WGR domain-containing protein 536056006604 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 536056006605 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 536056006606 MoxR-like ATPases [General function prediction only]; Region: COG0714 536056006607 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536056006608 Walker A motif; other site 536056006609 ATP binding site [chemical binding]; other site 536056006610 Walker B motif; other site 536056006611 arginine finger; other site 536056006612 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 536056006613 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 536056006614 metal ion-dependent adhesion site (MIDAS); other site 536056006615 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 536056006616 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 536056006617 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 536056006618 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 536056006619 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 536056006620 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536056006621 active site 536056006622 phosphorylation site [posttranslational modification] 536056006623 intermolecular recognition site; other site 536056006624 dimerization interface [polypeptide binding]; other site 536056006625 LytTr DNA-binding domain; Region: LytTR; pfam04397 536056006626 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 536056006627 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 536056006628 GAF domain; Region: GAF; pfam01590 536056006629 Histidine kinase; Region: His_kinase; pfam06580 536056006630 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536056006631 ATP binding site [chemical binding]; other site 536056006632 Mg2+ binding site [ion binding]; other site 536056006633 G-X-G motif; other site 536056006634 transcriptional regulator MirA; Provisional; Region: PRK15043 536056006635 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 536056006636 DNA binding residues [nucleotide binding] 536056006637 hypothetical protein; Provisional; Region: PRK13681 536056006638 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 536056006639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056006640 dimer interface [polypeptide binding]; other site 536056006641 conserved gate region; other site 536056006642 putative PBP binding loops; other site 536056006643 ABC-ATPase subunit interface; other site 536056006644 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 536056006645 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 536056006646 Walker A/P-loop; other site 536056006647 ATP binding site [chemical binding]; other site 536056006648 Q-loop/lid; other site 536056006649 ABC transporter signature motif; other site 536056006650 Walker B; other site 536056006651 D-loop; other site 536056006652 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 536056006653 H-loop/switch region; other site 536056006654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056006655 dimer interface [polypeptide binding]; other site 536056006656 conserved gate region; other site 536056006657 ABC-ATPase subunit interface; other site 536056006658 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 536056006659 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 536056006660 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 536056006661 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 536056006662 D-lactate dehydrogenase; Provisional; Region: PRK11183 536056006663 FAD binding domain; Region: FAD_binding_4; pfam01565 536056006664 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 536056006665 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 536056006666 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 536056006667 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 536056006668 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 536056006669 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 536056006670 oxidoreductase; Provisional; Region: PRK12743 536056006671 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 536056006672 NAD(P) binding site [chemical binding]; other site 536056006673 active site 536056006674 potential frameshift: common BLAST hit: gi|253772934|ref|YP_003035765.1| multidrug resistance outer membrane protein MdtQ 536056006675 Outer membrane efflux protein; Region: OEP; pfam02321 536056006676 Outer membrane efflux protein; Region: OEP; pfam02321 536056006677 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 536056006678 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 536056006679 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 536056006680 FMN binding site [chemical binding]; other site 536056006681 active site 536056006682 catalytic residues [active] 536056006683 substrate binding site [chemical binding]; other site 536056006684 hypothetical protein; Provisional; Region: PRK01821 536056006685 hypothetical protein; Provisional; Region: PRK10711 536056006686 cytidine deaminase; Provisional; Region: PRK09027 536056006687 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 536056006688 active site 536056006689 catalytic motif [active] 536056006690 Zn binding site [ion binding]; other site 536056006691 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 536056006692 active site 536056006693 catalytic motif [active] 536056006694 Zn binding site [ion binding]; other site 536056006695 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 536056006696 putative active site [active] 536056006697 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 536056006698 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 536056006699 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 536056006700 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 536056006701 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 536056006702 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 536056006703 homodimer interface [polypeptide binding]; other site 536056006704 active site 536056006705 FMN binding site [chemical binding]; other site 536056006706 substrate binding site [chemical binding]; other site 536056006707 4Fe-4S binding domain; Region: Fer4; pfam00037 536056006708 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536056006709 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536056006710 TM-ABC transporter signature motif; other site 536056006711 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536056006712 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 536056006713 Walker A/P-loop; other site 536056006714 ATP binding site [chemical binding]; other site 536056006715 Q-loop/lid; other site 536056006716 ABC transporter signature motif; other site 536056006717 Walker B; other site 536056006718 D-loop; other site 536056006719 H-loop/switch region; other site 536056006720 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 536056006721 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 536056006722 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 536056006723 ligand binding site [chemical binding]; other site 536056006724 calcium binding site [ion binding]; other site 536056006725 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 536056006726 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 536056006727 DNA binding site [nucleotide binding] 536056006728 domain linker motif; other site 536056006729 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 536056006730 dimerization interface (closed form) [polypeptide binding]; other site 536056006731 ligand binding site [chemical binding]; other site 536056006732 Predicted membrane protein [Function unknown]; Region: COG2311 536056006733 hypothetical protein; Provisional; Region: PRK10835 536056006734 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 536056006735 homodecamer interface [polypeptide binding]; other site 536056006736 GTP cyclohydrolase I; Provisional; Region: PLN03044 536056006737 active site 536056006738 putative catalytic site residues [active] 536056006739 zinc binding site [ion binding]; other site 536056006740 GTP-CH-I/GFRP interaction surface; other site 536056006741 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 536056006742 S-formylglutathione hydrolase; Region: PLN02442 536056006743 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 536056006744 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 536056006745 N-terminal plug; other site 536056006746 ligand-binding site [chemical binding]; other site 536056006747 lysine transporter; Provisional; Region: PRK10836 536056006748 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 536056006749 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056006750 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 536056006751 putative dimerization interface [polypeptide binding]; other site 536056006752 conserved hypothetical integral membrane protein; Region: TIGR00698 536056006753 endonuclease IV; Provisional; Region: PRK01060 536056006754 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 536056006755 AP (apurinic/apyrimidinic) site pocket; other site 536056006756 DNA interaction; other site 536056006757 Metal-binding active site; metal-binding site 536056006758 putative kinase; Provisional; Region: PRK09954 536056006759 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 536056006760 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 536056006761 substrate binding site [chemical binding]; other site 536056006762 ATP binding site [chemical binding]; other site 536056006763 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 536056006764 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 536056006765 Nucleoside recognition; Region: Gate; pfam07670 536056006766 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 536056006767 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 536056006768 active site 536056006769 tetramer interface [polypeptide binding]; other site 536056006770 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 536056006771 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 536056006772 ligand binding site [chemical binding]; other site 536056006773 flexible hinge region; other site 536056006774 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 536056006775 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 536056006776 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 536056006777 Nucleoside recognition; Region: Gate; pfam07670 536056006778 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 536056006779 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 536056006780 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 536056006781 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 536056006782 substrate binding site [chemical binding]; other site 536056006783 ATP binding site [chemical binding]; other site 536056006784 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 536056006785 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 536056006786 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 536056006787 active site 536056006788 P-loop; other site 536056006789 phosphorylation site [posttranslational modification] 536056006790 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 536056006791 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 536056006792 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 536056006793 putative substrate binding site [chemical binding]; other site 536056006794 putative ATP binding site [chemical binding]; other site 536056006795 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 536056006796 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 536056006797 active site 536056006798 phosphorylation site [posttranslational modification] 536056006799 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 536056006800 dimerization domain swap beta strand [polypeptide binding]; other site 536056006801 regulatory protein interface [polypeptide binding]; other site 536056006802 active site 536056006803 regulatory phosphorylation site [posttranslational modification]; other site 536056006804 sugar efflux transporter B; Provisional; Region: PRK15011 536056006805 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056006806 putative substrate translocation pore; other site 536056006807 Flagellin N-methylase; Region: FliB; pfam03692 536056006808 elongation factor P; Provisional; Region: PRK04542 536056006809 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 536056006810 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 536056006811 RNA binding site [nucleotide binding]; other site 536056006812 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 536056006813 RNA binding site [nucleotide binding]; other site 536056006814 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 536056006815 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 536056006816 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 536056006817 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 536056006818 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 536056006819 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 536056006820 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 536056006821 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 536056006822 active site 536056006823 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 536056006824 NlpC/P60 family; Region: NLPC_P60; pfam00877 536056006825 phage resistance protein; Provisional; Region: PRK10551 536056006826 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 536056006827 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 536056006828 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 536056006829 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 536056006830 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 536056006831 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056006832 dimer interface [polypeptide binding]; other site 536056006833 conserved gate region; other site 536056006834 putative PBP binding loops; other site 536056006835 ABC-ATPase subunit interface; other site 536056006836 microcin C ABC transporter permease; Provisional; Region: PRK15021 536056006837 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056006838 dimer interface [polypeptide binding]; other site 536056006839 conserved gate region; other site 536056006840 ABC-ATPase subunit interface; other site 536056006841 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 536056006842 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536056006843 Walker A/P-loop; other site 536056006844 ATP binding site [chemical binding]; other site 536056006845 Q-loop/lid; other site 536056006846 ABC transporter signature motif; other site 536056006847 Walker B; other site 536056006848 D-loop; other site 536056006849 H-loop/switch region; other site 536056006850 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 536056006851 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536056006852 Walker A/P-loop; other site 536056006853 ATP binding site [chemical binding]; other site 536056006854 Q-loop/lid; other site 536056006855 ABC transporter signature motif; other site 536056006856 Walker B; other site 536056006857 D-loop; other site 536056006858 H-loop/switch region; other site 536056006859 hypothetical protein; Provisional; Region: PRK11835 536056006860 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056006861 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 536056006862 putative substrate translocation pore; other site 536056006863 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 536056006864 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 536056006865 RNA binding surface [nucleotide binding]; other site 536056006866 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 536056006867 active site 536056006868 uracil binding [chemical binding]; other site 536056006869 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 536056006870 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 536056006871 ATP binding site [chemical binding]; other site 536056006872 putative Mg++ binding site [ion binding]; other site 536056006873 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 536056006874 nucleotide binding region [chemical binding]; other site 536056006875 ATP-binding site [chemical binding]; other site 536056006876 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 536056006877 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 536056006878 5S rRNA interface [nucleotide binding]; other site 536056006879 CTC domain interface [polypeptide binding]; other site 536056006880 L16 interface [polypeptide binding]; other site 536056006881 Nucleoid-associated protein [General function prediction only]; Region: COG3081 536056006882 nucleoid-associated protein NdpA; Validated; Region: PRK00378 536056006883 hypothetical protein; Provisional; Region: PRK13689 536056006884 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 536056006885 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 536056006886 Sulfatase; Region: Sulfatase; pfam00884 536056006887 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 536056006888 hypothetical protein; Provisional; Region: PRK09945 536056006889 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 536056006890 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 536056006891 Autotransporter beta-domain; Region: Autotransporter; pfam03797 536056006892 Transposase domain (DUF772); Region: DUF772; pfam05598 536056006893 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 536056006894 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 536056006895 transcriptional regulator NarP; Provisional; Region: PRK10403 536056006896 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536056006897 active site 536056006898 phosphorylation site [posttranslational modification] 536056006899 intermolecular recognition site; other site 536056006900 dimerization interface [polypeptide binding]; other site 536056006901 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536056006902 DNA binding residues [nucleotide binding] 536056006903 dimerization interface [polypeptide binding]; other site 536056006904 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 536056006905 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 536056006906 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536056006907 binding surface 536056006908 TPR motif; other site 536056006909 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 536056006910 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 536056006911 catalytic residues [active] 536056006912 central insert; other site 536056006913 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 536056006914 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 536056006915 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 536056006916 heme exporter protein CcmC; Region: ccmC; TIGR01191 536056006917 heme exporter protein CcmB; Region: ccmB; TIGR01190 536056006918 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 536056006919 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 536056006920 Walker A/P-loop; other site 536056006921 ATP binding site [chemical binding]; other site 536056006922 Q-loop/lid; other site 536056006923 ABC transporter signature motif; other site 536056006924 Walker B; other site 536056006925 D-loop; other site 536056006926 H-loop/switch region; other site 536056006927 cytochrome c-type protein NapC; Provisional; Region: PRK10617 536056006928 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 536056006929 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 536056006930 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 536056006931 4Fe-4S binding domain; Region: Fer4_5; pfam12801 536056006932 4Fe-4S binding domain; Region: Fer4_6; pfam12837 536056006933 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 536056006934 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 536056006935 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 536056006936 [4Fe-4S] binding site [ion binding]; other site 536056006937 molybdopterin cofactor binding site; other site 536056006938 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 536056006939 molybdopterin cofactor binding site; other site 536056006940 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 536056006941 ferredoxin-type protein; Provisional; Region: PRK10194 536056006942 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 536056006943 secondary substrate binding site; other site 536056006944 primary substrate binding site; other site 536056006945 inhibition loop; other site 536056006946 dimerization interface [polypeptide binding]; other site 536056006947 malate:quinone oxidoreductase; Validated; Region: PRK05257 536056006948 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 536056006949 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 536056006950 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 536056006951 Walker A/P-loop; other site 536056006952 ATP binding site [chemical binding]; other site 536056006953 Q-loop/lid; other site 536056006954 ABC transporter signature motif; other site 536056006955 Walker B; other site 536056006956 D-loop; other site 536056006957 H-loop/switch region; other site 536056006958 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 536056006959 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 536056006960 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 536056006961 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536056006962 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536056006963 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 536056006964 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 536056006965 DNA binding site [nucleotide binding] 536056006966 active site 536056006967 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 536056006968 ApbE family; Region: ApbE; pfam02424 536056006969 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 536056006970 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 536056006971 trimer interface [polypeptide binding]; other site 536056006972 eyelet of channel; other site 536056006973 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 536056006974 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536056006975 ATP binding site [chemical binding]; other site 536056006976 G-X-G motif; other site 536056006977 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 536056006978 putative binding surface; other site 536056006979 active site 536056006980 transcriptional regulator RcsB; Provisional; Region: PRK10840 536056006981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536056006982 active site 536056006983 phosphorylation site [posttranslational modification] 536056006984 intermolecular recognition site; other site 536056006985 dimerization interface [polypeptide binding]; other site 536056006986 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536056006987 DNA binding residues [nucleotide binding] 536056006988 dimerization interface [polypeptide binding]; other site 536056006989 'function: Signal transduction histidine kinase; hybrid sensory kinase in two-component regulatory system, pseudogene fragment due to insertion' 536056006990 'function: Signal transduction histidine kinase; hybrid sensory kinase in two-component regulatory system, pseudogene fragment due to insertion' 536056006991 sensory histidine kinase AtoS; Provisional; Region: PRK11360 536056006992 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536056006993 putative active site [active] 536056006994 heme pocket [chemical binding]; other site 536056006995 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536056006996 dimer interface [polypeptide binding]; other site 536056006997 phosphorylation site [posttranslational modification] 536056006998 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536056006999 ATP binding site [chemical binding]; other site 536056007000 Mg2+ binding site [ion binding]; other site 536056007001 G-X-G motif; other site 536056007002 acetoacetate metabolism regulatory protein AtoC; Provisional; Region: PRK11361 536056007003 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536056007004 active site 536056007005 phosphorylation site [posttranslational modification] 536056007006 intermolecular recognition site; other site 536056007007 dimerization interface [polypeptide binding]; other site 536056007008 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536056007009 Walker A motif; other site 536056007010 ATP binding site [chemical binding]; other site 536056007011 Walker B motif; other site 536056007012 arginine finger; other site 536056007013 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 536056007014 acetyl-CoA:acetoacetyl-CoA transferase subunit alpha; Provisional; Region: PRK09920 536056007015 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 536056007016 Short chain fatty acid transporter; Region: SCFA_trans; pfam02667 536056007017 putative acyltransferase; Provisional; Region: PRK05790 536056007018 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 536056007019 dimer interface [polypeptide binding]; other site 536056007020 active site 536056007021 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 536056007022 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 536056007023 Predicted secreted protein [Function unknown]; Region: COG5445 536056007024 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 536056007025 Predicted secreted protein [Function unknown]; Region: COG5445 536056007026 Stage II sporulation protein; Region: SpoIID; pfam08486 536056007027 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 536056007028 potential frameshift: common BLAST hit: gi|260856209|ref|YP_003230100.1| alpha-2-macroglobulin 536056007029 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 536056007030 MG2 domain; Region: A2M_N; pfam01835 536056007031 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 536056007032 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 536056007033 Alpha-2-macroglobulin family; Region: A2M; pfam00207 536056007034 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 536056007035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 536056007036 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4685 536056007037 DNA gyrase subunit A; Validated; Region: PRK05560 536056007038 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 536056007039 CAP-like domain; other site 536056007040 active site 536056007041 primary dimer interface [polypeptide binding]; other site 536056007042 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 536056007043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 536056007044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 536056007045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 536056007046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 536056007047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 536056007048 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 536056007049 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536056007050 S-adenosylmethionine binding site [chemical binding]; other site 536056007051 adhesin; Provisional; Region: PRK09752 536056007052 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 536056007053 Autotransporter beta-domain; Region: Autotransporter; pfam03797 536056007054 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 536056007055 ATP cone domain; Region: ATP-cone; pfam03477 536056007056 Class I ribonucleotide reductase; Region: RNR_I; cd01679 536056007057 active site 536056007058 dimer interface [polypeptide binding]; other site 536056007059 catalytic residues [active] 536056007060 effector binding site; other site 536056007061 R2 peptide binding site; other site 536056007062 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 536056007063 dimer interface [polypeptide binding]; other site 536056007064 putative radical transfer pathway; other site 536056007065 diiron center [ion binding]; other site 536056007066 tyrosyl radical; other site 536056007067 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 536056007068 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 536056007069 catalytic loop [active] 536056007070 iron binding site [ion binding]; other site 536056007071 hypothetical protein; Provisional; Region: PRK09902 536056007072 hypothetical protein; Provisional; Region: PRK09729 536056007073 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 536056007074 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 536056007075 active site 536056007076 catalytic site [active] 536056007077 metal binding site [ion binding]; metal-binding site 536056007078 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 536056007079 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056007080 putative substrate translocation pore; other site 536056007081 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 536056007082 hydroxyglutarate oxidase; Provisional; Region: PRK11728 536056007083 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 536056007084 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 536056007085 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 536056007086 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 536056007087 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 536056007088 Cysteine-rich domain; Region: CCG; pfam02754 536056007089 Cysteine-rich domain; Region: CCG; pfam02754 536056007090 hypothetical protein; Provisional; Region: PRK09956 536056007091 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 536056007092 hypothetical protein; Provisional; Region: PRK09956 536056007093 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 536056007094 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 536056007095 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056007096 putative substrate translocation pore; other site 536056007097 L-rhamnonate dehydratase; Provisional; Region: PRK15440 536056007098 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 536056007099 putative active site pocket [active] 536056007100 putative metal binding site [ion binding]; other site 536056007101 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 536056007102 Transcriptional regulator [Transcription]; Region: IclR; COG1414 536056007103 Bacterial transcriptional regulator; Region: IclR; pfam01614 536056007104 hypothetical protein; Provisional; Region: PRK03673 536056007105 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 536056007106 putative MPT binding site; other site 536056007107 Competence-damaged protein; Region: CinA; cl00666 536056007108 YfaZ precursor; Region: YfaZ; pfam07437 536056007109 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 536056007110 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 536056007111 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 536056007112 catalytic core [active] 536056007113 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 536056007114 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 536056007115 inhibitor-cofactor binding pocket; inhibition site 536056007116 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056007117 catalytic residue [active] 536056007118 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 536056007119 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 536056007120 Ligand binding site; other site 536056007121 Putative Catalytic site; other site 536056007122 DXD motif; other site 536056007123 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 536056007124 ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644 536056007125 substrate binding site [chemical binding]; other site 536056007126 cosubstrate binding site; other site 536056007127 catalytic site [active] 536056007128 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 536056007129 active site 536056007130 hexamer interface [polypeptide binding]; other site 536056007131 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 536056007132 NAD binding site [chemical binding]; other site 536056007133 substrate binding site [chemical binding]; other site 536056007134 active site 536056007135 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 536056007136 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 536056007137 putative active site [active] 536056007138 putative catalytic site [active] 536056007139 putative Zn binding site [ion binding]; other site 536056007140 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 536056007141 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 536056007142 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 536056007143 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 536056007144 signal transduction protein PmrD; Provisional; Region: PRK15450 536056007145 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 536056007146 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 536056007147 acyl-activating enzyme (AAE) consensus motif; other site 536056007148 putative AMP binding site [chemical binding]; other site 536056007149 putative active site [active] 536056007150 putative CoA binding site [chemical binding]; other site 536056007151 O-succinylbenzoate synthase; Provisional; Region: PRK05105 536056007152 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 536056007153 active site 536056007154 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 536056007155 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 536056007156 substrate binding site [chemical binding]; other site 536056007157 oxyanion hole (OAH) forming residues; other site 536056007158 trimer interface [polypeptide binding]; other site 536056007159 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 536056007160 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 536056007161 nucleophilic elbow; other site 536056007162 catalytic triad; other site 536056007163 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 536056007164 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 536056007165 dimer interface [polypeptide binding]; other site 536056007166 tetramer interface [polypeptide binding]; other site 536056007167 PYR/PP interface [polypeptide binding]; other site 536056007168 TPP binding site [chemical binding]; other site 536056007169 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 536056007170 TPP-binding site; other site 536056007171 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 536056007172 isochorismate synthases; Region: isochor_syn; TIGR00543 536056007173 hypothetical protein; Provisional; Region: PRK10404 536056007174 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536056007175 Coenzyme A binding pocket [chemical binding]; other site 536056007176 ribonuclease BN; Region: true_RNase_BN; TIGR02649 536056007177 deubiquitinase; Provisional; Region: PRK11836 536056007178 von Willebrand factor; Region: vWF_A; pfam12450 536056007179 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 536056007180 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 536056007181 metal ion-dependent adhesion site (MIDAS); other site 536056007182 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 536056007183 M28 Zn-Peptidases; Region: M28_like_1; cd05640 536056007184 Peptidase family M28; Region: Peptidase_M28; pfam04389 536056007185 metal binding site [ion binding]; metal-binding site 536056007186 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 536056007187 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 536056007188 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 536056007189 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 536056007190 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 536056007191 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 536056007192 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 536056007193 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 536056007194 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 536056007195 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 536056007196 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 536056007197 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 536056007198 4Fe-4S binding domain; Region: Fer4; pfam00037 536056007199 4Fe-4S binding domain; Region: Fer4; pfam00037 536056007200 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 536056007201 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 536056007202 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 536056007203 catalytic loop [active] 536056007204 iron binding site [ion binding]; other site 536056007205 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 536056007206 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 536056007207 [4Fe-4S] binding site [ion binding]; other site 536056007208 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 536056007209 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 536056007210 SLBB domain; Region: SLBB; pfam10531 536056007211 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 536056007212 NADH dehydrogenase subunit E; Validated; Region: PRK07539 536056007213 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 536056007214 putative dimer interface [polypeptide binding]; other site 536056007215 [2Fe-2S] cluster binding site [ion binding]; other site 536056007216 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 536056007217 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 536056007218 NADH dehydrogenase subunit D; Validated; Region: PRK06075 536056007219 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 536056007220 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 536056007221 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 536056007222 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056007223 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 536056007224 putative dimerization interface [polypeptide binding]; other site 536056007225 aminotransferase AlaT; Validated; Region: PRK09265 536056007226 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 536056007227 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056007228 homodimer interface [polypeptide binding]; other site 536056007229 catalytic residue [active] 536056007230 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 536056007231 Zn2+ binding site [ion binding]; other site 536056007232 Mg2+ binding site [ion binding]; other site 536056007233 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 536056007234 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 536056007235 TrkA-C domain; Region: TrkA_C; pfam02080 536056007236 TrkA-C domain; Region: TrkA_C; pfam02080 536056007237 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 536056007238 putative phosphatase; Provisional; Region: PRK11587 536056007239 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536056007240 motif II; other site 536056007241 hypothetical protein; Validated; Region: PRK05445 536056007242 hypothetical protein; Provisional; Region: PRK01816 536056007243 propionate/acetate kinase; Provisional; Region: PRK12379 536056007244 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 536056007245 phosphate acetyltransferase; Reviewed; Region: PRK05632 536056007246 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 536056007247 DRTGG domain; Region: DRTGG; pfam07085 536056007248 phosphate acetyltransferase; Region: pta; TIGR00651 536056007249 hypothetical protein; Provisional; Region: PRK11588 536056007250 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 536056007251 potential protein location (hypothetical protein) that overlaps protein (inner membrane protein) 536056007252 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 536056007253 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 536056007254 nudix motif; other site 536056007255 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 536056007256 active site 536056007257 metal binding site [ion binding]; metal-binding site 536056007258 homotetramer interface [polypeptide binding]; other site 536056007259 glutathione S-transferase; Provisional; Region: PRK15113 536056007260 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 536056007261 C-terminal domain interface [polypeptide binding]; other site 536056007262 GSH binding site (G-site) [chemical binding]; other site 536056007263 dimer interface [polypeptide binding]; other site 536056007264 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 536056007265 N-terminal domain interface [polypeptide binding]; other site 536056007266 putative dimer interface [polypeptide binding]; other site 536056007267 putative substrate binding pocket (H-site) [chemical binding]; other site 536056007268 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 536056007269 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 536056007270 C-terminal domain interface [polypeptide binding]; other site 536056007271 GSH binding site (G-site) [chemical binding]; other site 536056007272 dimer interface [polypeptide binding]; other site 536056007273 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 536056007274 N-terminal domain interface [polypeptide binding]; other site 536056007275 putative dimer interface [polypeptide binding]; other site 536056007276 active site 536056007277 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 536056007278 homooctamer interface [polypeptide binding]; other site 536056007279 active site 536056007280 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 536056007281 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 536056007282 putative NAD(P) binding site [chemical binding]; other site 536056007283 putative active site [active] 536056007284 putative transposase; Provisional; Region: PRK09857 536056007285 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 536056007286 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 536056007287 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 536056007288 Walker A/P-loop; other site 536056007289 ATP binding site [chemical binding]; other site 536056007290 Q-loop/lid; other site 536056007291 ABC transporter signature motif; other site 536056007292 Walker B; other site 536056007293 D-loop; other site 536056007294 H-loop/switch region; other site 536056007295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056007296 dimer interface [polypeptide binding]; other site 536056007297 conserved gate region; other site 536056007298 putative PBP binding loops; other site 536056007299 ABC-ATPase subunit interface; other site 536056007300 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 536056007301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056007302 dimer interface [polypeptide binding]; other site 536056007303 conserved gate region; other site 536056007304 putative PBP binding loops; other site 536056007305 ABC-ATPase subunit interface; other site 536056007306 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 536056007307 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536056007308 substrate binding pocket [chemical binding]; other site 536056007309 membrane-bound complex binding site; other site 536056007310 hinge residues; other site 536056007311 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 536056007312 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536056007313 substrate binding pocket [chemical binding]; other site 536056007314 membrane-bound complex binding site; other site 536056007315 hinge residues; other site 536056007316 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 536056007317 Flavoprotein; Region: Flavoprotein; pfam02441 536056007318 amidophosphoribosyltransferase; Provisional; Region: PRK09246 536056007319 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 536056007320 active site 536056007321 tetramer interface [polypeptide binding]; other site 536056007322 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 536056007323 active site 536056007324 colicin V production protein; Provisional; Region: PRK10845 536056007325 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 536056007326 cell division protein DedD; Provisional; Region: PRK11633 536056007327 Sporulation related domain; Region: SPOR; pfam05036 536056007328 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 536056007329 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 536056007330 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 536056007331 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 536056007332 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 536056007333 hypothetical protein; Provisional; Region: PRK10847 536056007334 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 536056007335 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 536056007336 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 536056007337 dimerization interface 3.5A [polypeptide binding]; other site 536056007338 active site 536056007339 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 536056007340 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 536056007341 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 536056007342 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 536056007343 ligand binding site [chemical binding]; other site 536056007344 NAD binding site [chemical binding]; other site 536056007345 catalytic site [active] 536056007346 homodimer interface [polypeptide binding]; other site 536056007347 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 536056007348 putative transporter; Provisional; Region: PRK12382 536056007349 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056007350 putative substrate translocation pore; other site 536056007351 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 536056007352 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 536056007353 dimer interface [polypeptide binding]; other site 536056007354 active site 536056007355 Uncharacterized conserved protein [Function unknown]; Region: COG4121 536056007356 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 536056007357 YfcL protein; Region: YfcL; pfam08891 536056007358 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 536056007359 hypothetical protein; Provisional; Region: PRK10621 536056007360 Predicted permeases [General function prediction only]; Region: COG0730 536056007361 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 536056007362 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 536056007363 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 536056007364 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 536056007365 Tetramer interface [polypeptide binding]; other site 536056007366 active site 536056007367 FMN-binding site [chemical binding]; other site 536056007368 HemK family putative methylases; Region: hemK_fam; TIGR00536 536056007369 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536056007370 S-adenosylmethionine binding site [chemical binding]; other site 536056007371 hypothetical protein; Provisional; Region: PRK04946 536056007372 Smr domain; Region: Smr; pfam01713 536056007373 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 536056007374 Fimbrial protein; Region: Fimbrial; cl01416 536056007375 Fimbrial protein; Region: Fimbrial; cl01416 536056007376 Fimbrial protein; Region: Fimbrial; cl01416 536056007377 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 536056007378 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 536056007379 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 536056007380 PapC C-terminal domain; Region: PapC_C; pfam13953 536056007381 PapC N-terminal domain; Region: PapC_N; pfam13954 536056007382 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 536056007383 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 536056007384 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 536056007385 catalytic core [active] 536056007386 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 536056007387 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 536056007388 substrate binding site [chemical binding]; other site 536056007389 oxyanion hole (OAH) forming residues; other site 536056007390 trimer interface [polypeptide binding]; other site 536056007391 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 536056007392 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 536056007393 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 536056007394 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 536056007395 dimer interface [polypeptide binding]; other site 536056007396 active site 536056007397 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 536056007398 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 536056007399 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 536056007400 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 536056007401 integrase; Provisional; Region: PRK09692 536056007402 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 536056007403 active site 536056007404 Int/Topo IB signature motif; other site 536056007405 Predicted membrane protein [Function unknown]; Region: COG2246 536056007406 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 536056007407 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 536056007408 Ligand binding site; other site 536056007409 Putative Catalytic site; other site 536056007410 DXD motif; other site 536056007411 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 536056007412 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 536056007413 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; cl05442 536056007414 PerC transcriptional activator; Region: PerC; pfam06069 536056007415 Uncharacterized conserved protein [Function unknown]; Region: COG5532 536056007416 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 536056007417 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 536056007418 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 536056007419 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056007420 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 536056007421 dimerization interface [polypeptide binding]; other site 536056007422 substrate binding pocket [chemical binding]; other site 536056007423 permease DsdX; Provisional; Region: PRK09921 536056007424 gluconate transporter; Region: gntP; TIGR00791 536056007425 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 536056007426 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 536056007427 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 536056007428 catalytic residue [active] 536056007429 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 536056007430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056007431 putative substrate translocation pore; other site 536056007432 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056007433 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 536056007434 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 536056007435 HlyD family secretion protein; Region: HlyD_3; pfam13437 536056007436 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 536056007437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536056007438 active site 536056007439 phosphorylation site [posttranslational modification] 536056007440 intermolecular recognition site; other site 536056007441 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536056007442 DNA binding residues [nucleotide binding] 536056007443 dimerization interface [polypeptide binding]; other site 536056007444 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 536056007445 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536056007446 substrate binding pocket [chemical binding]; other site 536056007447 membrane-bound complex binding site; other site 536056007448 hinge residues; other site 536056007449 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536056007450 substrate binding pocket [chemical binding]; other site 536056007451 membrane-bound complex binding site; other site 536056007452 hinge residues; other site 536056007453 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536056007454 dimer interface [polypeptide binding]; other site 536056007455 phosphorylation site [posttranslational modification] 536056007456 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536056007457 ATP binding site [chemical binding]; other site 536056007458 Mg2+ binding site [ion binding]; other site 536056007459 G-X-G motif; other site 536056007460 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536056007461 active site 536056007462 phosphorylation site [posttranslational modification] 536056007463 intermolecular recognition site; other site 536056007464 dimerization interface [polypeptide binding]; other site 536056007465 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 536056007466 putative binding surface; other site 536056007467 active site 536056007468 putative CoA-transferase; Provisional; Region: PRK11430 536056007469 CoA-transferase family III; Region: CoA_transf_3; pfam02515 536056007470 putative transporter YfdV; Provisional; Region: PRK09903 536056007471 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 536056007472 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 536056007473 PYR/PP interface [polypeptide binding]; other site 536056007474 dimer interface [polypeptide binding]; other site 536056007475 TPP binding site [chemical binding]; other site 536056007476 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 536056007477 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 536056007478 TPP-binding site; other site 536056007479 dimer interface [polypeptide binding]; other site 536056007480 formyl-coenzyme A transferase; Provisional; Region: PRK05398 536056007481 CoA-transferase family III; Region: CoA_transf_3; pfam02515 536056007482 hypothetical protein; Provisional; Region: PRK10316 536056007483 YfdX protein; Region: YfdX; pfam10938 536056007484 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 536056007485 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 536056007486 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 536056007487 putative acyl-acceptor binding pocket; other site 536056007488 aminotransferase; Validated; Region: PRK08175 536056007489 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 536056007490 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056007491 homodimer interface [polypeptide binding]; other site 536056007492 catalytic residue [active] 536056007493 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 536056007494 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 536056007495 GAF domain; Region: GAF; pfam01590 536056007496 Histidine kinase; Region: His_kinase; pfam06580 536056007497 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536056007498 ATP binding site [chemical binding]; other site 536056007499 Mg2+ binding site [ion binding]; other site 536056007500 G-X-G motif; other site 536056007501 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 536056007502 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536056007503 active site 536056007504 phosphorylation site [posttranslational modification] 536056007505 intermolecular recognition site; other site 536056007506 dimerization interface [polypeptide binding]; other site 536056007507 LytTr DNA-binding domain; Region: LytTR; pfam04397 536056007508 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 536056007509 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536056007510 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 536056007511 dimerization domain swap beta strand [polypeptide binding]; other site 536056007512 regulatory protein interface [polypeptide binding]; other site 536056007513 active site 536056007514 regulatory phosphorylation site [posttranslational modification]; other site 536056007515 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 536056007516 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 536056007517 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 536056007518 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 536056007519 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 536056007520 active site 536056007521 phosphorylation site [posttranslational modification] 536056007522 exoaminopeptidase; Provisional; Region: PRK09961 536056007523 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 536056007524 oligomer interface [polypeptide binding]; other site 536056007525 active site 536056007526 metal binding site [ion binding]; metal-binding site 536056007527 aminopeptidase; Provisional; Region: PRK09795 536056007528 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 536056007529 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 536056007530 active site 536056007531 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 536056007532 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 536056007533 active site 536056007534 P-loop; other site 536056007535 phosphorylation site [posttranslational modification] 536056007536 glucokinase, proteobacterial type; Region: glk; TIGR00749 536056007537 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 536056007538 nucleotide binding site [chemical binding]; other site 536056007539 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 536056007540 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 536056007541 Cl- selectivity filter; other site 536056007542 Cl- binding residues [ion binding]; other site 536056007543 pore gating glutamate residue; other site 536056007544 dimer interface [polypeptide binding]; other site 536056007545 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 536056007546 manganese transport protein MntH; Reviewed; Region: PRK00701 536056007547 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 536056007548 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 536056007549 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 536056007550 Nucleoside recognition; Region: Gate; pfam07670 536056007551 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 536056007552 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 536056007553 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 536056007554 MASE1; Region: MASE1; pfam05231 536056007555 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 536056007556 diguanylate cyclase; Region: GGDEF; smart00267 536056007557 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 536056007558 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 536056007559 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536056007560 salt bridge; other site 536056007561 non-specific DNA binding site [nucleotide binding]; other site 536056007562 sequence-specific DNA binding site [nucleotide binding]; other site 536056007563 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 536056007564 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 536056007565 active site 536056007566 HIGH motif; other site 536056007567 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 536056007568 active site 536056007569 KMSKS motif; other site 536056007570 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 536056007571 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056007572 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 536056007573 putative dimerization interface [polypeptide binding]; other site 536056007574 putative substrate binding pocket [chemical binding]; other site 536056007575 XapX domain; Region: XapX; TIGR03510 536056007576 nucleoside transporter; Region: 2A0110; TIGR00889 536056007577 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056007578 putative substrate translocation pore; other site 536056007579 purine nucleoside phosphorylase; Provisional; Region: PRK08202 536056007580 hypothetical protein; Provisional; Region: PRK11528 536056007581 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536056007582 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056007583 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 536056007584 putative dimerization interface [polypeptide binding]; other site 536056007585 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 536056007586 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 536056007587 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 536056007588 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 536056007589 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 536056007590 nucleotide binding pocket [chemical binding]; other site 536056007591 K-X-D-G motif; other site 536056007592 catalytic site [active] 536056007593 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 536056007594 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 536056007595 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 536056007596 Dimer interface [polypeptide binding]; other site 536056007597 BRCT sequence motif; other site 536056007598 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 536056007599 cell division protein ZipA; Provisional; Region: PRK03427 536056007600 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 536056007601 FtsZ protein binding site [polypeptide binding]; other site 536056007602 putative sulfate transport protein CysZ; Validated; Region: PRK04949 536056007603 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 536056007604 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 536056007605 dimer interface [polypeptide binding]; other site 536056007606 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056007607 catalytic residue [active] 536056007608 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 536056007609 dimerization domain swap beta strand [polypeptide binding]; other site 536056007610 regulatory protein interface [polypeptide binding]; other site 536056007611 active site 536056007612 regulatory phosphorylation site [posttranslational modification]; other site 536056007613 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 536056007614 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 536056007615 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 536056007616 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 536056007617 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 536056007618 HPr interaction site; other site 536056007619 glycerol kinase (GK) interaction site [polypeptide binding]; other site 536056007620 active site 536056007621 phosphorylation site [posttranslational modification] 536056007622 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 536056007623 dimer interface [polypeptide binding]; other site 536056007624 pyridoxamine kinase; Validated; Region: PRK05756 536056007625 pyridoxal binding site [chemical binding]; other site 536056007626 ATP binding site [chemical binding]; other site 536056007627 hypothetical protein; Provisional; Region: PRK10318 536056007628 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 536056007629 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884 536056007630 cysteine synthase B; Region: cysM; TIGR01138 536056007631 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 536056007632 dimer interface [polypeptide binding]; other site 536056007633 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056007634 catalytic residue [active] 536056007635 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 536056007636 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 536056007637 Walker A/P-loop; other site 536056007638 ATP binding site [chemical binding]; other site 536056007639 Q-loop/lid; other site 536056007640 ABC transporter signature motif; other site 536056007641 Walker B; other site 536056007642 D-loop; other site 536056007643 H-loop/switch region; other site 536056007644 TOBE-like domain; Region: TOBE_3; pfam12857 536056007645 sulfate transport protein; Provisional; Region: cysT; CHL00187 536056007646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056007647 dimer interface [polypeptide binding]; other site 536056007648 conserved gate region; other site 536056007649 putative PBP binding loops; other site 536056007650 ABC-ATPase subunit interface; other site 536056007651 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 536056007652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056007653 dimer interface [polypeptide binding]; other site 536056007654 conserved gate region; other site 536056007655 putative PBP binding loops; other site 536056007656 ABC-ATPase subunit interface; other site 536056007657 thiosulfate transporter subunit; Provisional; Region: PRK10852 536056007658 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 536056007659 short chain dehydrogenase; Provisional; Region: PRK08226 536056007660 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 536056007661 NAD binding site [chemical binding]; other site 536056007662 homotetramer interface [polypeptide binding]; other site 536056007663 homodimer interface [polypeptide binding]; other site 536056007664 active site 536056007665 transcriptional regulator MurR; Provisional; Region: PRK15482 536056007666 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 536056007667 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 536056007668 putative active site [active] 536056007669 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 536056007670 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 536056007671 putative active site [active] 536056007672 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 536056007673 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 536056007674 active site turn [active] 536056007675 phosphorylation site [posttranslational modification] 536056007676 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 536056007677 putative periplasmic esterase; Provisional; Region: PRK03642 536056007678 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 536056007679 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 536056007680 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 536056007681 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 536056007682 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 536056007683 putative acetyltransferase; Provisional; Region: PRK03624 536056007684 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536056007685 Coenzyme A binding pocket [chemical binding]; other site 536056007686 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 536056007687 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 536056007688 active site 536056007689 metal binding site [ion binding]; metal-binding site 536056007690 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 536056007691 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 536056007692 transcriptional regulator EutR; Provisional; Region: PRK10130 536056007693 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536056007694 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536056007695 carboxysome structural protein EutK; Provisional; Region: PRK15466 536056007696 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 536056007697 Hexamer interface [polypeptide binding]; other site 536056007698 Hexagonal pore residue; other site 536056007699 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 536056007700 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 536056007701 putative hexamer interface [polypeptide binding]; other site 536056007702 putative hexagonal pore; other site 536056007703 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 536056007704 putative hexamer interface [polypeptide binding]; other site 536056007705 putative hexagonal pore; other site 536056007706 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 536056007707 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 536056007708 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 536056007709 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 536056007710 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 536056007711 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 536056007712 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 536056007713 active site 536056007714 metal binding site [ion binding]; metal-binding site 536056007715 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 536056007716 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 536056007717 nucleotide binding site [chemical binding]; other site 536056007718 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 536056007719 putative catalytic cysteine [active] 536056007720 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 536056007721 Hexamer/Pentamer interface [polypeptide binding]; other site 536056007722 central pore; other site 536056007723 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 536056007724 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 536056007725 Hexamer interface [polypeptide binding]; other site 536056007726 Putative hexagonal pore residue; other site 536056007727 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 536056007728 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 536056007729 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 536056007730 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 536056007731 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 536056007732 G1 box; other site 536056007733 GTP/Mg2+ binding site [chemical binding]; other site 536056007734 G2 box; other site 536056007735 Switch I region; other site 536056007736 G3 box; other site 536056007737 Switch II region; other site 536056007738 G4 box; other site 536056007739 G5 box; other site 536056007740 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 536056007741 putative hexamer interface [polypeptide binding]; other site 536056007742 putative hexagonal pore; other site 536056007743 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 536056007744 Malic enzyme, N-terminal domain; Region: malic; pfam00390 536056007745 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 536056007746 putative NAD(P) binding site [chemical binding]; other site 536056007747 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 536056007748 transaldolase-like protein; Provisional; Region: PTZ00411 536056007749 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 536056007750 active site 536056007751 dimer interface [polypeptide binding]; other site 536056007752 catalytic residue [active] 536056007753 transketolase; Reviewed; Region: PRK12753 536056007754 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 536056007755 TPP-binding site [chemical binding]; other site 536056007756 dimer interface [polypeptide binding]; other site 536056007757 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 536056007758 PYR/PP interface [polypeptide binding]; other site 536056007759 dimer interface [polypeptide binding]; other site 536056007760 TPP binding site [chemical binding]; other site 536056007761 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 536056007762 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 536056007763 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 536056007764 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 536056007765 dimer interface [polypeptide binding]; other site 536056007766 ADP-ribose binding site [chemical binding]; other site 536056007767 active site 536056007768 nudix motif; other site 536056007769 metal binding site [ion binding]; metal-binding site 536056007770 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 536056007771 4Fe-4S binding domain; Region: Fer4; pfam00037 536056007772 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 536056007773 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 536056007774 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 536056007775 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 536056007776 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 536056007777 dimerization interface [polypeptide binding]; other site 536056007778 Histidine kinase; Region: HisKA_3; pfam07730 536056007779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536056007780 ATP binding site [chemical binding]; other site 536056007781 Mg2+ binding site [ion binding]; other site 536056007782 G-X-G motif; other site 536056007783 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 536056007784 Protein export membrane protein; Region: SecD_SecF; cl14618 536056007785 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 536056007786 ArsC family; Region: ArsC; pfam03960 536056007787 putative catalytic residues [active] 536056007788 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 536056007789 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 536056007790 metal binding site [ion binding]; metal-binding site 536056007791 dimer interface [polypeptide binding]; other site 536056007792 hypothetical protein; Provisional; Region: PRK13664 536056007793 putative hydrolase; Provisional; Region: PRK11460 536056007794 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 536056007795 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 536056007796 Helicase; Region: Helicase_RecD; pfam05127 536056007797 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 536056007798 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 536056007799 Predicted metalloprotease [General function prediction only]; Region: COG2321 536056007800 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 536056007801 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 536056007802 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 536056007803 ATP binding site [chemical binding]; other site 536056007804 active site 536056007805 substrate binding site [chemical binding]; other site 536056007806 lipoprotein; Provisional; Region: PRK11679 536056007807 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 536056007808 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 536056007809 dihydrodipicolinate synthase; Region: dapA; TIGR00674 536056007810 dimer interface [polypeptide binding]; other site 536056007811 active site 536056007812 catalytic residue [active] 536056007813 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 536056007814 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 536056007815 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 536056007816 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 536056007817 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 536056007818 catalytic triad [active] 536056007819 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 536056007820 4Fe-4S binding domain; Region: Fer4; pfam00037 536056007821 hydrogenase 4 subunit B; Validated; Region: PRK06521 536056007822 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 536056007823 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 536056007824 NADH dehydrogenase; Region: NADHdh; cl00469 536056007825 hydrogenase 4 subunit D; Validated; Region: PRK06525 536056007826 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 536056007827 hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492 536056007828 hydrogenase 4 subunit F; Validated; Region: PRK06458 536056007829 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 536056007830 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 536056007831 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 536056007832 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 536056007833 hydrogenase 4 subunit H; Validated; Region: PRK08222 536056007834 4Fe-4S binding domain; Region: Fer4; pfam00037 536056007835 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 536056007836 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 536056007837 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 536056007838 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 536056007839 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536056007840 Walker A motif; other site 536056007841 ATP binding site [chemical binding]; other site 536056007842 Walker B motif; other site 536056007843 arginine finger; other site 536056007844 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 536056007845 putative formate transporter; Provisional; Region: focB; PRK09713 536056007846 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 536056007847 Domain of unknown function DUF20; Region: UPF0118; pfam01594 536056007848 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 536056007849 Peptidase family M48; Region: Peptidase_M48; cl12018 536056007850 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 536056007851 ArsC family; Region: ArsC; pfam03960 536056007852 catalytic residues [active] 536056007853 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 536056007854 DNA replication initiation factor; Provisional; Region: PRK08084 536056007855 uracil transporter; Provisional; Region: PRK10720 536056007856 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 536056007857 active site 536056007858 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 536056007859 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 536056007860 dimerization interface [polypeptide binding]; other site 536056007861 putative ATP binding site [chemical binding]; other site 536056007862 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 536056007863 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 536056007864 active site 536056007865 substrate binding site [chemical binding]; other site 536056007866 cosubstrate binding site; other site 536056007867 catalytic site [active] 536056007868 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 536056007869 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 536056007870 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 536056007871 Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114 536056007872 domain interface [polypeptide binding]; other site 536056007873 active site 536056007874 catalytic site [active] 536056007875 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 536056007876 putative active site [active] 536056007877 catalytic site [active] 536056007878 exopolyphosphatase; Provisional; Region: PRK10854 536056007879 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 536056007880 MASE1; Region: MASE1; pfam05231 536056007881 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 536056007882 diguanylate cyclase; Region: GGDEF; smart00267 536056007883 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 536056007884 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 536056007885 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 536056007886 GMP synthase; Reviewed; Region: guaA; PRK00074 536056007887 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 536056007888 AMP/PPi binding site [chemical binding]; other site 536056007889 candidate oxyanion hole; other site 536056007890 catalytic triad [active] 536056007891 potential glutamine specificity residues [chemical binding]; other site 536056007892 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 536056007893 ATP Binding subdomain [chemical binding]; other site 536056007894 Ligand Binding sites [chemical binding]; other site 536056007895 Dimerization subdomain; other site 536056007896 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 536056007897 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 536056007898 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 536056007899 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 536056007900 active site 536056007901 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 536056007902 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 536056007903 generic binding surface II; other site 536056007904 generic binding surface I; other site 536056007905 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 536056007906 GTP-binding protein Der; Reviewed; Region: PRK00093 536056007907 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 536056007908 G1 box; other site 536056007909 GTP/Mg2+ binding site [chemical binding]; other site 536056007910 Switch I region; other site 536056007911 G2 box; other site 536056007912 Switch II region; other site 536056007913 G3 box; other site 536056007914 G4 box; other site 536056007915 G5 box; other site 536056007916 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 536056007917 G1 box; other site 536056007918 GTP/Mg2+ binding site [chemical binding]; other site 536056007919 Switch I region; other site 536056007920 G2 box; other site 536056007921 G3 box; other site 536056007922 Switch II region; other site 536056007923 G4 box; other site 536056007924 G5 box; other site 536056007925 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 536056007926 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cd00216 536056007927 Trp docking motif [polypeptide binding]; other site 536056007928 active site 536056007929 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 536056007930 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 536056007931 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 536056007932 dimer interface [polypeptide binding]; other site 536056007933 motif 1; other site 536056007934 active site 536056007935 motif 2; other site 536056007936 motif 3; other site 536056007937 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 536056007938 anticodon binding site; other site 536056007939 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 536056007940 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 536056007941 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 536056007942 cytoskeletal protein RodZ; Provisional; Region: PRK10856 536056007943 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536056007944 non-specific DNA binding site [nucleotide binding]; other site 536056007945 salt bridge; other site 536056007946 sequence-specific DNA binding site [nucleotide binding]; other site 536056007947 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 536056007948 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 536056007949 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 536056007950 FeS/SAM binding site; other site 536056007951 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 536056007952 active site 536056007953 multimer interface [polypeptide binding]; other site 536056007954 penicillin-binding protein 1C; Provisional; Region: PRK11240 536056007955 Transglycosylase; Region: Transgly; pfam00912 536056007956 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 536056007957 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 536056007958 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 536056007959 MG2 domain; Region: A2M_N; pfam01835 536056007960 Alpha-2-macroglobulin family; Region: A2M; pfam00207 536056007961 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 536056007962 surface patch; other site 536056007963 thioester region; other site 536056007964 specificity defining residues; other site 536056007965 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 536056007966 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 536056007967 active site residue [active] 536056007968 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 536056007969 active site residue [active] 536056007970 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 536056007971 aminopeptidase B; Provisional; Region: PRK05015 536056007972 Peptidase; Region: DUF3663; pfam12404 536056007973 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 536056007974 interface (dimer of trimers) [polypeptide binding]; other site 536056007975 Substrate-binding/catalytic site; other site 536056007976 Zn-binding sites [ion binding]; other site 536056007977 hypothetical protein; Provisional; Region: PRK10721 536056007978 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 536056007979 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 536056007980 catalytic loop [active] 536056007981 iron binding site [ion binding]; other site 536056007982 chaperone protein HscA; Provisional; Region: hscA; PRK05183 536056007983 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 536056007984 nucleotide binding site [chemical binding]; other site 536056007985 putative NEF/HSP70 interaction site [polypeptide binding]; other site 536056007986 SBD interface [polypeptide binding]; other site 536056007987 co-chaperone HscB; Provisional; Region: hscB; PRK05014 536056007988 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 536056007989 HSP70 interaction site [polypeptide binding]; other site 536056007990 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 536056007991 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 536056007992 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 536056007993 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 536056007994 trimerization site [polypeptide binding]; other site 536056007995 active site 536056007996 cysteine desulfurase; Provisional; Region: PRK14012 536056007997 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 536056007998 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 536056007999 catalytic residue [active] 536056008000 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 536056008001 Rrf2 family protein; Region: rrf2_super; TIGR00738 536056008002 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 536056008003 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 536056008004 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 536056008005 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 536056008006 active site 536056008007 dimerization interface [polypeptide binding]; other site 536056008008 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 536056008009 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 536056008010 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 536056008011 PRD domain; Region: PRD; pfam00874 536056008012 PRD domain; Region: PRD; pfam00874 536056008013 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 536056008014 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056008015 putative substrate translocation pore; other site 536056008016 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 536056008017 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056008018 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 536056008019 dimerization interface [polypeptide binding]; other site 536056008020 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 536056008021 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 536056008022 iron-sulfur cluster [ion binding]; other site 536056008023 [2Fe-2S] cluster binding site [ion binding]; other site 536056008024 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 536056008025 beta subunit interface [polypeptide binding]; other site 536056008026 alpha subunit interface [polypeptide binding]; other site 536056008027 active site 536056008028 substrate binding site [chemical binding]; other site 536056008029 Fe binding site [ion binding]; other site 536056008030 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 536056008031 inter-subunit interface; other site 536056008032 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 536056008033 [2Fe-2S] cluster binding site [ion binding]; other site 536056008034 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 536056008035 cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB)-like, classical (c) SDRs; Region: BphB-like_SDR_c; cd05348 536056008036 NAD binding site [chemical binding]; other site 536056008037 active site 536056008038 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 536056008039 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 536056008040 Predicted membrane protein [Function unknown]; Region: COG2259 536056008041 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 536056008042 active site 536056008043 catalytic residues [active] 536056008044 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 536056008045 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 536056008046 putative NAD(P) binding site [chemical binding]; other site 536056008047 catalytic Zn binding site [ion binding]; other site 536056008048 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536056008049 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536056008050 TM-ABC transporter signature motif; other site 536056008051 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 536056008052 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536056008053 Walker A/P-loop; other site 536056008054 ATP binding site [chemical binding]; other site 536056008055 Q-loop/lid; other site 536056008056 ABC transporter signature motif; other site 536056008057 Walker B; other site 536056008058 D-loop; other site 536056008059 H-loop/switch region; other site 536056008060 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 536056008061 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 536056008062 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 536056008063 ligand binding site [chemical binding]; other site 536056008064 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536056008065 TPR motif; other site 536056008066 Tetratricopeptide repeat; Region: TPR_16; pfam13432 536056008067 binding surface 536056008068 TPR repeat; Region: TPR_11; pfam13414 536056008069 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536056008070 TPR motif; other site 536056008071 binding surface 536056008072 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 536056008073 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 536056008074 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 536056008075 nucleotide binding site [chemical binding]; other site 536056008076 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 536056008077 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 536056008078 dimer interface [polypeptide binding]; other site 536056008079 active site 536056008080 glycine-pyridoxal phosphate binding site [chemical binding]; other site 536056008081 folate binding site [chemical binding]; other site 536056008082 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 536056008083 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 536056008084 heme-binding site [chemical binding]; other site 536056008085 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 536056008086 FAD binding pocket [chemical binding]; other site 536056008087 FAD binding motif [chemical binding]; other site 536056008088 phosphate binding motif [ion binding]; other site 536056008089 beta-alpha-beta structure motif; other site 536056008090 NAD binding pocket [chemical binding]; other site 536056008091 Heme binding pocket [chemical binding]; other site 536056008092 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 536056008093 Nitrogen regulatory protein P-II; Region: P-II; smart00938 536056008094 response regulator GlrR; Provisional; Region: PRK15115 536056008095 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536056008096 active site 536056008097 phosphorylation site [posttranslational modification] 536056008098 intermolecular recognition site; other site 536056008099 dimerization interface [polypeptide binding]; other site 536056008100 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536056008101 Walker A motif; other site 536056008102 ATP binding site [chemical binding]; other site 536056008103 Walker B motif; other site 536056008104 arginine finger; other site 536056008105 hypothetical protein; Provisional; Region: PRK10722 536056008106 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 536056008107 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536056008108 dimer interface [polypeptide binding]; other site 536056008109 phosphorylation site [posttranslational modification] 536056008110 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536056008111 ATP binding site [chemical binding]; other site 536056008112 Mg2+ binding site [ion binding]; other site 536056008113 G-X-G motif; other site 536056008114 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 536056008115 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 536056008116 dimerization interface [polypeptide binding]; other site 536056008117 ATP binding site [chemical binding]; other site 536056008118 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 536056008119 dimerization interface [polypeptide binding]; other site 536056008120 ATP binding site [chemical binding]; other site 536056008121 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 536056008122 putative active site [active] 536056008123 catalytic triad [active] 536056008124 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 536056008125 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536056008126 substrate binding pocket [chemical binding]; other site 536056008127 membrane-bound complex binding site; other site 536056008128 hinge residues; other site 536056008129 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 536056008130 N-acetyl-D-glucosamine binding site [chemical binding]; other site 536056008131 catalytic residue [active] 536056008132 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 536056008133 nucleoside/Zn binding site; other site 536056008134 dimer interface [polypeptide binding]; other site 536056008135 catalytic motif [active] 536056008136 hypothetical protein; Provisional; Region: PRK11590 536056008137 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 536056008138 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 536056008139 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 536056008140 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 536056008141 putative active site [active] 536056008142 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 536056008143 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 536056008144 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 536056008145 active site 536056008146 hydrophilic channel; other site 536056008147 dimerization interface [polypeptide binding]; other site 536056008148 catalytic residues [active] 536056008149 active site lid [active] 536056008150 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 536056008151 Recombination protein O N terminal; Region: RecO_N; pfam11967 536056008152 Recombination protein O C terminal; Region: RecO_C; pfam02565 536056008153 GTPase Era; Reviewed; Region: era; PRK00089 536056008154 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 536056008155 G1 box; other site 536056008156 GTP/Mg2+ binding site [chemical binding]; other site 536056008157 Switch I region; other site 536056008158 G2 box; other site 536056008159 Switch II region; other site 536056008160 G3 box; other site 536056008161 G4 box; other site 536056008162 G5 box; other site 536056008163 KH domain; Region: KH_2; pfam07650 536056008164 ribonuclease III; Reviewed; Region: rnc; PRK00102 536056008165 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 536056008166 dimerization interface [polypeptide binding]; other site 536056008167 active site 536056008168 metal binding site [ion binding]; metal-binding site 536056008169 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 536056008170 dsRNA binding site [nucleotide binding]; other site 536056008171 signal peptidase I; Provisional; Region: PRK10861 536056008172 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 536056008173 Catalytic site [active] 536056008174 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 536056008175 GTP-binding protein LepA; Provisional; Region: PRK05433 536056008176 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 536056008177 G1 box; other site 536056008178 putative GEF interaction site [polypeptide binding]; other site 536056008179 GTP/Mg2+ binding site [chemical binding]; other site 536056008180 Switch I region; other site 536056008181 G2 box; other site 536056008182 G3 box; other site 536056008183 Switch II region; other site 536056008184 G4 box; other site 536056008185 G5 box; other site 536056008186 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 536056008187 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 536056008188 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 536056008189 SoxR reducing system protein RseC; Provisional; Region: PRK10862 536056008190 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 536056008191 anti-sigma E factor; Provisional; Region: rseB; PRK09455 536056008192 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 536056008193 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 536056008194 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 536056008195 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 536056008196 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 536056008197 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 536056008198 DNA binding residues [nucleotide binding] 536056008199 L-aspartate oxidase; Provisional; Region: PRK09077 536056008200 L-aspartate oxidase; Provisional; Region: PRK06175 536056008201 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 536056008202 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 536056008203 Methyltransferase domain; Region: Methyltransf_26; pfam13659 536056008204 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 536056008205 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 536056008206 ATP binding site [chemical binding]; other site 536056008207 Mg++ binding site [ion binding]; other site 536056008208 motif III; other site 536056008209 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 536056008210 nucleotide binding region [chemical binding]; other site 536056008211 ATP-binding site [chemical binding]; other site 536056008212 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536056008213 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056008214 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 536056008215 dimerization interface [polypeptide binding]; other site 536056008216 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 536056008217 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 536056008218 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 536056008219 ligand binding site [chemical binding]; other site 536056008220 active site 536056008221 UGI interface [polypeptide binding]; other site 536056008222 catalytic site [active] 536056008223 putative methyltransferase; Provisional; Region: PRK10864 536056008224 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 536056008225 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 536056008226 thioredoxin 2; Provisional; Region: PRK10996 536056008227 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 536056008228 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 536056008229 catalytic residues [active] 536056008230 Uncharacterized conserved protein [Function unknown]; Region: COG3148 536056008231 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 536056008232 CoA binding domain; Region: CoA_binding_2; pfam13380 536056008233 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 536056008234 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 536056008235 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 536056008236 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 536056008237 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 536056008238 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 536056008239 domain interface [polypeptide binding]; other site 536056008240 putative active site [active] 536056008241 catalytic site [active] 536056008242 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 536056008243 domain interface [polypeptide binding]; other site 536056008244 putative active site [active] 536056008245 catalytic site [active] 536056008246 lipoprotein; Provisional; Region: PRK10759 536056008247 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 536056008248 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056008249 putative substrate translocation pore; other site 536056008250 protein disaggregation chaperone; Provisional; Region: PRK10865 536056008251 Clp amino terminal domain; Region: Clp_N; pfam02861 536056008252 Clp amino terminal domain; Region: Clp_N; pfam02861 536056008253 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536056008254 Walker A motif; other site 536056008255 ATP binding site [chemical binding]; other site 536056008256 Walker B motif; other site 536056008257 arginine finger; other site 536056008258 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536056008259 Walker A motif; other site 536056008260 ATP binding site [chemical binding]; other site 536056008261 Walker B motif; other site 536056008262 arginine finger; other site 536056008263 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 536056008264 hypothetical protein; Provisional; Region: PRK10723 536056008265 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 536056008266 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 536056008267 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 536056008268 RNA binding surface [nucleotide binding]; other site 536056008269 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 536056008270 active site 536056008271 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 536056008272 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 536056008273 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 536056008274 30S subunit binding site; other site 536056008275 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 536056008276 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 536056008277 Prephenate dehydratase; Region: PDT; pfam00800 536056008278 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 536056008279 putative L-Phe binding site [chemical binding]; other site 536056008280 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 536056008281 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 536056008282 prephenate dehydrogenase; Validated; Region: PRK08507 536056008283 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 536056008284 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 536056008285 lipoprotein; Provisional; Region: PRK11443 536056008286 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 536056008287 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 536056008288 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 536056008289 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 536056008290 metal binding site [ion binding]; metal-binding site 536056008291 active site 536056008292 I-site; other site 536056008293 putative outer membrane lipoprotein; Provisional; Region: PRK09967 536056008294 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 536056008295 ligand binding site [chemical binding]; other site 536056008296 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 536056008297 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 536056008298 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 536056008299 RimM N-terminal domain; Region: RimM; pfam01782 536056008300 PRC-barrel domain; Region: PRC; pfam05239 536056008301 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 536056008302 signal recognition particle protein; Provisional; Region: PRK10867 536056008303 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 536056008304 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 536056008305 P loop; other site 536056008306 GTP binding site [chemical binding]; other site 536056008307 Signal peptide binding domain; Region: SRP_SPB; pfam02978 536056008308 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 536056008309 hypothetical protein; Provisional; Region: PRK11573 536056008310 Domain of unknown function DUF21; Region: DUF21; pfam01595 536056008311 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 536056008312 Transporter associated domain; Region: CorC_HlyC; smart01091 536056008313 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 536056008314 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 536056008315 dimer interface [polypeptide binding]; other site 536056008316 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 536056008317 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 536056008318 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 536056008319 recombination and repair protein; Provisional; Region: PRK10869 536056008320 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 536056008321 Walker A/P-loop; other site 536056008322 ATP binding site [chemical binding]; other site 536056008323 Q-loop/lid; other site 536056008324 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 536056008325 Q-loop/lid; other site 536056008326 ABC transporter signature motif; other site 536056008327 Walker B; other site 536056008328 D-loop; other site 536056008329 H-loop/switch region; other site 536056008330 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 536056008331 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 536056008332 hypothetical protein; Validated; Region: PRK01777 536056008333 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 536056008334 putative coenzyme Q binding site [chemical binding]; other site 536056008335 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 536056008336 SmpB-tmRNA interface; other site 536056008337 integrase; Provisional; Region: PRK09692 536056008338 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 536056008339 active site 536056008340 Int/Topo IB signature motif; other site 536056008341 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 536056008342 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 536056008343 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 536056008344 Superfamily II helicase [General function prediction only]; Region: COG1204 536056008345 DEAD/DEAH box helicase; Region: DEAD; pfam00270 536056008346 helicase superfamily c-terminal domain; Region: HELICc; smart00490 536056008347 nucleotide binding region [chemical binding]; other site 536056008348 ATP-binding site [chemical binding]; other site 536056008349 Domain of unknown function (DUF4297); Region: DUF4297; pfam14130 536056008350 Domain of unknown function (DUF1837); Region: DUF1837; pfam08878 536056008351 Predicted GTPase [General function prediction only]; Region: COG3596 536056008352 YfjP GTPase; Region: YfjP; cd11383 536056008353 G1 box; other site 536056008354 GTP/Mg2+ binding site [chemical binding]; other site 536056008355 Switch I region; other site 536056008356 G2 box; other site 536056008357 Switch II region; other site 536056008358 G3 box; other site 536056008359 G4 box; other site 536056008360 G5 box; other site 536056008361 Domain of unknown function (DUF932); Region: DUF932; pfam06067 536056008362 Predicted transcriptional regulator [Transcription]; Region: COG2378 536056008363 HTH domain; Region: HTH_11; cl17392 536056008364 WYL domain; Region: WYL; pfam13280 536056008365 Predicted transcriptional regulator [Transcription]; Region: COG2378 536056008366 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 536056008367 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 536056008368 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 536056008369 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 536056008370 Antirestriction protein; Region: Antirestrict; pfam03230 536056008371 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 536056008372 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 536056008373 MPN+ (JAMM) motif; other site 536056008374 Zinc-binding site [ion binding]; other site 536056008375 Protein of unknown function (DUF987); Region: DUF987; pfam06174 536056008376 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 536056008377 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 536056008378 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 536056008379 hypothetical protein; Provisional; Region: PRK09945 536056008380 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 536056008381 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 536056008382 Autotransporter beta-domain; Region: Autotransporter; pfam03797 536056008383 potential frameshift: common BLAST hit: gi|170019090|ref|YP_001724044.1| alpha amylase 536056008384 potential frameshift: common BLAST hit: gi|170019090|ref|YP_001724044.1| alpha amylase 536056008385 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 536056008386 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 536056008387 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 536056008388 active site 536056008389 catalytic site [active] 536056008390 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 536056008391 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 536056008392 substrate binding pocket [chemical binding]; other site 536056008393 active site 536056008394 iron coordination sites [ion binding]; other site 536056008395 Predicted dehydrogenase [General function prediction only]; Region: COG0579 536056008396 hydroxyglutarate oxidase; Provisional; Region: PRK11728 536056008397 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 536056008398 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 536056008399 tetramerization interface [polypeptide binding]; other site 536056008400 NAD(P) binding site [chemical binding]; other site 536056008401 catalytic residues [active] 536056008402 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 536056008403 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 536056008404 inhibitor-cofactor binding pocket; inhibition site 536056008405 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056008406 catalytic residue [active] 536056008407 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 536056008408 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 536056008409 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536056008410 DNA-binding site [nucleotide binding]; DNA binding site 536056008411 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 536056008412 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 536056008413 bacterial OsmY and nodulation domain; Region: BON; smart00749 536056008414 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 536056008415 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 536056008416 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536056008417 dimerization interface [polypeptide binding]; other site 536056008418 putative DNA binding site [nucleotide binding]; other site 536056008419 Transcriptional regulators [Transcription]; Region: MarR; COG1846 536056008420 putative Zn2+ binding site [ion binding]; other site 536056008421 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527 536056008422 active site residue [active] 536056008423 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 536056008424 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 536056008425 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 536056008426 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 536056008427 hypothetical protein; Provisional; Region: PRK10556 536056008428 hypothetical protein; Provisional; Region: PRK10132 536056008429 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 536056008430 catalytic residues [active] 536056008431 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 536056008432 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 536056008433 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 536056008434 Class I ribonucleotide reductase; Region: RNR_I; cd01679 536056008435 active site 536056008436 dimer interface [polypeptide binding]; other site 536056008437 catalytic residues [active] 536056008438 effector binding site; other site 536056008439 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 536056008440 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 536056008441 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 536056008442 dimer interface [polypeptide binding]; other site 536056008443 putative radical transfer pathway; other site 536056008444 diiron center [ion binding]; other site 536056008445 tyrosyl radical; other site 536056008446 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 536056008447 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 536056008448 Walker A/P-loop; other site 536056008449 ATP binding site [chemical binding]; other site 536056008450 Q-loop/lid; other site 536056008451 ABC transporter signature motif; other site 536056008452 Walker B; other site 536056008453 D-loop; other site 536056008454 H-loop/switch region; other site 536056008455 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 536056008456 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 536056008457 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056008458 dimer interface [polypeptide binding]; other site 536056008459 conserved gate region; other site 536056008460 putative PBP binding loops; other site 536056008461 ABC-ATPase subunit interface; other site 536056008462 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 536056008463 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 536056008464 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 536056008465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 536056008466 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056008467 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 536056008468 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 536056008469 putative L-valine exporter; Provisional; Region: PRK10408 536056008470 transcriptional repressor MprA; Provisional; Region: PRK10870 536056008471 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 536056008472 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 536056008473 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 536056008474 HlyD family secretion protein; Region: HlyD_3; pfam13437 536056008475 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 536056008476 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056008477 putative substrate translocation pore; other site 536056008478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056008479 'S-ribosylhomocysteinase, stop codon appeared; function: LuxS protein involved in autoinducer AI2 synthesis' 536056008480 glutamate--cysteine ligase; Provisional; Region: PRK02107 536056008481 Predicted membrane protein [Function unknown]; Region: COG1238 536056008482 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 536056008483 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536056008484 motif II; other site 536056008485 carbon storage regulator; Provisional; Region: PRK01712 536056008486 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 536056008487 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 536056008488 motif 1; other site 536056008489 active site 536056008490 motif 2; other site 536056008491 motif 3; other site 536056008492 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 536056008493 DHHA1 domain; Region: DHHA1; pfam02272 536056008494 recombination regulator RecX; Reviewed; Region: recX; PRK00117 536056008495 recombinase A; Provisional; Region: recA; PRK09354 536056008496 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 536056008497 hexamer interface [polypeptide binding]; other site 536056008498 Walker A motif; other site 536056008499 ATP binding site [chemical binding]; other site 536056008500 Walker B motif; other site 536056008501 hypothetical protein; Validated; Region: PRK03661 536056008502 Transglycosylase SLT domain; Region: SLT_2; pfam13406 536056008503 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 536056008504 N-acetyl-D-glucosamine binding site [chemical binding]; other site 536056008505 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 536056008506 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 536056008507 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 536056008508 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 536056008509 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 536056008510 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 536056008511 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 536056008512 putative NAD(P) binding site [chemical binding]; other site 536056008513 active site 536056008514 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 536056008515 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 536056008516 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 536056008517 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 536056008518 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 536056008519 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 536056008520 putative active site [active] 536056008521 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 536056008522 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 536056008523 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 536056008524 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536056008525 Walker A motif; other site 536056008526 ATP binding site [chemical binding]; other site 536056008527 Walker B motif; other site 536056008528 arginine finger; other site 536056008529 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 536056008530 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 536056008531 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 536056008532 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 536056008533 iron binding site [ion binding]; other site 536056008534 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 536056008535 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 536056008536 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 536056008537 Acylphosphatase; Region: Acylphosphatase; pfam00708 536056008538 HypF finger; Region: zf-HYPF; pfam07503 536056008539 HypF finger; Region: zf-HYPF; pfam07503 536056008540 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 536056008541 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 536056008542 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 536056008543 Transcriptional regulators [Transcription]; Region: PurR; COG1609 536056008544 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 536056008545 DNA binding site [nucleotide binding] 536056008546 domain linker motif; other site 536056008547 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 536056008548 dimerization interface (closed form) [polypeptide binding]; other site 536056008549 ligand binding site [chemical binding]; other site 536056008550 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 536056008551 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 536056008552 active site turn [active] 536056008553 phosphorylation site [posttranslational modification] 536056008554 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 536056008555 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 536056008556 beta-galactosidase; Region: BGL; TIGR03356 536056008557 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 536056008558 nickel binding site [ion binding]; other site 536056008559 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 536056008560 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 536056008561 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 536056008562 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 536056008563 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 536056008564 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 536056008565 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 536056008566 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 536056008567 NADH dehydrogenase; Region: NADHdh; cl00469 536056008568 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 536056008569 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 536056008570 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 536056008571 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 536056008572 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 536056008573 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 536056008574 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 536056008575 hydrogenase assembly chaperone; Provisional; Region: PRK10409 536056008576 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 536056008577 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 536056008578 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 536056008579 dimerization interface [polypeptide binding]; other site 536056008580 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 536056008581 ATP binding site [chemical binding]; other site 536056008582 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 536056008583 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 536056008584 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 536056008585 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536056008586 Walker A motif; other site 536056008587 ATP binding site [chemical binding]; other site 536056008588 Walker B motif; other site 536056008589 arginine finger; other site 536056008590 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 536056008591 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 536056008592 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 536056008593 MutS domain I; Region: MutS_I; pfam01624 536056008594 MutS domain II; Region: MutS_II; pfam05188 536056008595 MutS domain III; Region: MutS_III; pfam05192 536056008596 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 536056008597 Walker A/P-loop; other site 536056008598 ATP binding site [chemical binding]; other site 536056008599 Q-loop/lid; other site 536056008600 ABC transporter signature motif; other site 536056008601 Walker B; other site 536056008602 D-loop; other site 536056008603 H-loop/switch region; other site 536056008604 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 536056008605 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 536056008606 active site 536056008607 metal binding site [ion binding]; metal-binding site 536056008608 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 536056008609 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 536056008610 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 536056008611 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 536056008612 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 536056008613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 536056008614 putative aldolase; Validated; Region: PRK08130 536056008615 active site 536056008616 intersubunit interface [polypeptide binding]; other site 536056008617 Zn2+ binding site [ion binding]; other site 536056008618 hypothetical protein; Provisional; Region: PRK09989 536056008619 putative transporter; Provisional; Region: PRK09821 536056008620 GntP family permease; Region: GntP_permease; pfam02447 536056008621 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 536056008622 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 536056008623 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 536056008624 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 536056008625 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 536056008626 DNA binding residues [nucleotide binding] 536056008627 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 536056008628 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 536056008629 Peptidase family M23; Region: Peptidase_M23; pfam01551 536056008630 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 536056008631 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536056008632 S-adenosylmethionine binding site [chemical binding]; other site 536056008633 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 536056008634 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 536056008635 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 536056008636 Permutation of conserved domain; other site 536056008637 active site 536056008638 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 536056008639 homotrimer interaction site [polypeptide binding]; other site 536056008640 zinc binding site [ion binding]; other site 536056008641 CDP-binding sites; other site 536056008642 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 536056008643 substrate binding site; other site 536056008644 dimer interface; other site 536056008645 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 536056008646 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 536056008647 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 536056008648 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 536056008649 ligand-binding site [chemical binding]; other site 536056008650 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 536056008651 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 536056008652 CysD dimerization site [polypeptide binding]; other site 536056008653 G1 box; other site 536056008654 putative GEF interaction site [polypeptide binding]; other site 536056008655 GTP/Mg2+ binding site [chemical binding]; other site 536056008656 Switch I region; other site 536056008657 G2 box; other site 536056008658 G3 box; other site 536056008659 Switch II region; other site 536056008660 G4 box; other site 536056008661 G5 box; other site 536056008662 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 536056008663 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 536056008664 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 536056008665 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 536056008666 Active Sites [active] 536056008667 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 536056008668 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 536056008669 metal binding site [ion binding]; metal-binding site 536056008670 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 536056008671 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 536056008672 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09664 536056008673 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 536056008674 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 536056008675 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646 536056008676 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09670 536056008677 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 536056008678 helicase Cas3; Provisional; Region: PRK09694 536056008679 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 536056008680 CRISPR/Cas system-associated protein Cas3; Region: Cas3_I; cd09639 536056008681 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 536056008682 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 536056008683 Active Sites [active] 536056008684 sulfite reductase subunit beta; Provisional; Region: PRK13504 536056008685 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 536056008686 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 536056008687 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 536056008688 Flavodoxin; Region: Flavodoxin_1; pfam00258 536056008689 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 536056008690 FAD binding pocket [chemical binding]; other site 536056008691 FAD binding motif [chemical binding]; other site 536056008692 catalytic residues [active] 536056008693 NAD binding pocket [chemical binding]; other site 536056008694 phosphate binding motif [ion binding]; other site 536056008695 beta-alpha-beta structure motif; other site 536056008696 6-pyruvoyl tetrahydropterin synthase (PTPS). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a...; Region: PTPS; cd00470 536056008697 homohexamer interface [polypeptide binding]; other site 536056008698 putative substrate stabilizing pore; other site 536056008699 pterin binding site; other site 536056008700 putative oxidoreductase FixC; Provisional; Region: PRK10157 536056008701 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 536056008702 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 536056008703 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 536056008704 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 536056008705 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 536056008706 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 536056008707 Ligand binding site [chemical binding]; other site 536056008708 Electron transfer flavoprotein domain; Region: ETF; pfam01012 536056008709 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 536056008710 benzoate transport; Region: 2A0115; TIGR00895 536056008711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056008712 putative substrate translocation pore; other site 536056008713 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 536056008714 FAD binding domain; Region: FAD_binding_4; pfam01565 536056008715 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 536056008716 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 536056008717 NADP binding site [chemical binding]; other site 536056008718 homodimer interface [polypeptide binding]; other site 536056008719 active site 536056008720 Major Facilitator Superfamily; Region: MFS_1; pfam07690 536056008721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056008722 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 536056008723 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 536056008724 nucleotide binding site [chemical binding]; other site 536056008725 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 536056008726 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 536056008727 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 536056008728 Repair protein; Region: Repair_PSII; pfam04536 536056008729 enolase; Provisional; Region: eno; PRK00077 536056008730 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 536056008731 dimer interface [polypeptide binding]; other site 536056008732 metal binding site [ion binding]; metal-binding site 536056008733 substrate binding pocket [chemical binding]; other site 536056008734 CTP synthetase; Validated; Region: pyrG; PRK05380 536056008735 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 536056008736 Catalytic site [active] 536056008737 active site 536056008738 UTP binding site [chemical binding]; other site 536056008739 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 536056008740 active site 536056008741 putative oxyanion hole; other site 536056008742 catalytic triad [active] 536056008743 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 536056008744 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 536056008745 homodimer interface [polypeptide binding]; other site 536056008746 metal binding site [ion binding]; metal-binding site 536056008747 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 536056008748 homodimer interface [polypeptide binding]; other site 536056008749 active site 536056008750 putative chemical substrate binding site [chemical binding]; other site 536056008751 metal binding site [ion binding]; metal-binding site 536056008752 toxin MazF; Provisional; Region: PRK09907 536056008753 antitoxin MazE; Provisional; Region: PRK09798 536056008754 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 536056008755 HD domain; Region: HD_4; pfam13328 536056008756 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 536056008757 synthetase active site [active] 536056008758 NTP binding site [chemical binding]; other site 536056008759 metal binding site [ion binding]; metal-binding site 536056008760 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 536056008761 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 536056008762 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 536056008763 TRAM domain; Region: TRAM; pfam01938 536056008764 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536056008765 S-adenosylmethionine binding site [chemical binding]; other site 536056008766 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 536056008767 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 536056008768 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 536056008769 dimerization interface [polypeptide binding]; other site 536056008770 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536056008771 dimer interface [polypeptide binding]; other site 536056008772 phosphorylation site [posttranslational modification] 536056008773 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536056008774 ATP binding site [chemical binding]; other site 536056008775 Mg2+ binding site [ion binding]; other site 536056008776 G-X-G motif; other site 536056008777 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 536056008778 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536056008779 active site 536056008780 phosphorylation site [posttranslational modification] 536056008781 intermolecular recognition site; other site 536056008782 dimerization interface [polypeptide binding]; other site 536056008783 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 536056008784 putative binding surface; other site 536056008785 active site 536056008786 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 536056008787 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 536056008788 active site 536056008789 tetramer interface [polypeptide binding]; other site 536056008790 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 536056008791 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 536056008792 active site 536056008793 tetramer interface [polypeptide binding]; other site 536056008794 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056008795 D-galactonate transporter; Region: 2A0114; TIGR00893 536056008796 putative substrate translocation pore; other site 536056008797 flavodoxin; Provisional; Region: PRK08105 536056008798 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 536056008799 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 536056008800 probable active site [active] 536056008801 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 536056008802 SecY interacting protein Syd; Provisional; Region: PRK04968 536056008803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 536056008804 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 536056008805 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 536056008806 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 536056008807 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 536056008808 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 536056008809 serine transporter; Region: stp; TIGR00814 536056008810 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 536056008811 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 536056008812 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 536056008813 flap endonuclease-like protein; Provisional; Region: PRK09482 536056008814 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 536056008815 active site 536056008816 metal binding site 1 [ion binding]; metal-binding site 536056008817 putative 5' ssDNA interaction site; other site 536056008818 metal binding site 3; metal-binding site 536056008819 metal binding site 2 [ion binding]; metal-binding site 536056008820 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 536056008821 putative DNA binding site [nucleotide binding]; other site 536056008822 putative metal binding site [ion binding]; other site 536056008823 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 536056008824 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 536056008825 dimer interface [polypeptide binding]; other site 536056008826 active site 536056008827 metal binding site [ion binding]; metal-binding site 536056008828 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 536056008829 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 536056008830 intersubunit interface [polypeptide binding]; other site 536056008831 active site 536056008832 Zn2+ binding site [ion binding]; other site 536056008833 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 536056008834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056008835 putative substrate translocation pore; other site 536056008836 L-fucose isomerase; Provisional; Region: fucI; PRK10991 536056008837 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 536056008838 hexamer (dimer of trimers) interface [polypeptide binding]; other site 536056008839 trimer interface [polypeptide binding]; other site 536056008840 substrate binding site [chemical binding]; other site 536056008841 Mn binding site [ion binding]; other site 536056008842 L-fuculokinase; Provisional; Region: PRK10331 536056008843 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 536056008844 nucleotide binding site [chemical binding]; other site 536056008845 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 536056008846 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 536056008847 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 536056008848 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 536056008849 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 536056008850 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 536056008851 hypothetical protein; Provisional; Region: PRK10873 536056008852 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 536056008853 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056008854 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 536056008855 dimerization interface [polypeptide binding]; other site 536056008856 substrate binding pocket [chemical binding]; other site 536056008857 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 536056008858 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 536056008859 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 536056008860 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 536056008861 catalytic residue [active] 536056008862 CsdA-binding activator; Provisional; Region: PRK15019 536056008863 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 536056008864 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 536056008865 putative ATP binding site [chemical binding]; other site 536056008866 putative substrate interface [chemical binding]; other site 536056008867 murein transglycosylase A; Provisional; Region: mltA; PRK11162 536056008868 MltA specific insert domain; Region: MltA; pfam03562 536056008869 3D domain; Region: 3D; pfam06725 536056008870 AMIN domain; Region: AMIN; pfam11741 536056008871 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 536056008872 active site 536056008873 metal binding site [ion binding]; metal-binding site 536056008874 N-acetylglutamate synthase; Validated; Region: PRK05279 536056008875 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 536056008876 putative feedback inhibition sensing region; other site 536056008877 putative nucleotide binding site [chemical binding]; other site 536056008878 putative substrate binding site [chemical binding]; other site 536056008879 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536056008880 Coenzyme A binding pocket [chemical binding]; other site 536056008881 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 536056008882 AAA domain; Region: AAA_30; pfam13604 536056008883 Family description; Region: UvrD_C_2; pfam13538 536056008884 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 536056008885 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 536056008886 protease3; Provisional; Region: PRK15101 536056008887 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 536056008888 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 536056008889 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 536056008890 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 536056008891 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 536056008892 hypothetical protein; Provisional; Region: PRK10332 536056008893 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 536056008894 hypothetical protein; Provisional; Region: PRK11521 536056008895 hypothetical protein; Provisional; Region: PRK10557 536056008896 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 536056008897 hypothetical protein; Provisional; Region: PRK10506 536056008898 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 536056008899 thymidylate synthase; Reviewed; Region: thyA; PRK01827 536056008900 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 536056008901 dimerization interface [polypeptide binding]; other site 536056008902 active site 536056008903 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 536056008904 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 536056008905 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 536056008906 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 536056008907 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 536056008908 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 536056008909 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 536056008910 putative active site [active] 536056008911 Ap4A binding site [chemical binding]; other site 536056008912 nudix motif; other site 536056008913 putative metal binding site [ion binding]; other site 536056008914 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 536056008915 putative DNA-binding cleft [nucleotide binding]; other site 536056008916 putative DNA clevage site; other site 536056008917 molecular lever; other site 536056008918 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 536056008919 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 536056008920 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 536056008921 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 536056008922 active site 536056008923 catalytic tetrad [active] 536056008924 lysophospholipid transporter LplT; Provisional; Region: PRK11195 536056008925 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056008926 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 536056008927 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 536056008928 putative acyl-acceptor binding pocket; other site 536056008929 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 536056008930 acyl-activating enzyme (AAE) consensus motif; other site 536056008931 putative AMP binding site [chemical binding]; other site 536056008932 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 536056008933 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 536056008934 DNA binding site [nucleotide binding] 536056008935 domain linker motif; other site 536056008936 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 536056008937 dimerization interface (closed form) [polypeptide binding]; other site 536056008938 ligand binding site [chemical binding]; other site 536056008939 diaminopimelate decarboxylase; Provisional; Region: PRK11165 536056008940 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 536056008941 active site 536056008942 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 536056008943 substrate binding site [chemical binding]; other site 536056008944 catalytic residues [active] 536056008945 dimer interface [polypeptide binding]; other site 536056008946 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 536056008947 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056008948 The C-terminal substrate binding domain of LysR, transcriptional regulator for lysine biosynthesis, contains the type 2 periplasmic binding fold; Region: PBP2_LysR; cd08456 536056008949 putative dimerization interface [polypeptide binding]; other site 536056008950 putative racemase; Provisional; Region: PRK10200 536056008951 aspartate racemase; Region: asp_race; TIGR00035 536056008952 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 536056008953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056008954 putative substrate translocation pore; other site 536056008955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056008956 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 536056008957 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 536056008958 NADP binding site [chemical binding]; other site 536056008959 homodimer interface [polypeptide binding]; other site 536056008960 active site 536056008961 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 536056008962 putative acyltransferase; Provisional; Region: PRK05790 536056008963 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 536056008964 dimer interface [polypeptide binding]; other site 536056008965 active site 536056008966 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 536056008967 serine transporter; Region: stp; TIGR00814 536056008968 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 536056008969 DNA binding residues [nucleotide binding] 536056008970 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 536056008971 'predicted protein, stop codon appeared' 536056008972 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 536056008973 Tetratricopeptide repeat; Region: TPR_3; pfam07720 536056008974 Tetratricopeptide repeat; Region: TPR_3; pfam07720 536056008975 transcriptional regulator; Provisional; Region: PRK11906 536056008976 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 536056008977 DNA binding site [nucleotide binding] 536056008978 Tetratricopeptide repeat; Region: TPR_2; pfam07719 536056008979 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 536056008980 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 536056008981 N-acetyl-D-glucosamine binding site [chemical binding]; other site 536056008982 catalytic residue [active] 536056008983 potential frameshift: common BLAST hit: gi|254794795|ref|YP_003079632.1| 2-component transcriptional regulator 536056008984 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 536056008985 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536056008986 DNA binding residues [nucleotide binding] 536056008987 dimerization interface [polypeptide binding]; other site 536056008988 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 536056008989 invasion protein OrgB; Provisional; Region: PRK15322 536056008990 Bacterial type III secretion apparatus protein (OrgA_MxiK); Region: OrgA_MxiK; cl09716 536056008991 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 536056008992 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 536056008993 Peptidase family M23; Region: Peptidase_M23; pfam01551 536056008994 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 536056008995 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 536056008996 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 536056008997 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 536056008998 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 536056008999 xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908 536056009000 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 536056009001 catalytic loop [active] 536056009002 iron binding site [ion binding]; other site 536056009003 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 536056009004 GAF domain; Region: GAF; cl17456 536056009005 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 536056009006 PAS domain; Region: PAS; smart00091 536056009007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536056009008 Walker A motif; other site 536056009009 ATP binding site [chemical binding]; other site 536056009010 Walker B motif; other site 536056009011 arginine finger; other site 536056009012 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 536056009013 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 536056009014 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 536056009015 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 536056009016 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 536056009017 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 536056009018 catalytic residue [active] 536056009019 peptidase; Reviewed; Region: PRK13004 536056009020 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 536056009021 putative metal binding site [ion binding]; other site 536056009022 putative dimer interface [polypeptide binding]; other site 536056009023 D-hydantoinase; Region: D-hydantoinase; TIGR02033 536056009024 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 536056009025 tetramer interface [polypeptide binding]; other site 536056009026 active site 536056009027 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 536056009028 carbamate kinase; Reviewed; Region: PRK12686 536056009029 putative substrate binding site [chemical binding]; other site 536056009030 homodimer interface [polypeptide binding]; other site 536056009031 nucleotide binding site [chemical binding]; other site 536056009032 nucleotide binding site [chemical binding]; other site 536056009033 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 536056009034 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 536056009035 XdhC Rossmann domain; Region: XdhC_C; pfam13478 536056009036 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 536056009037 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 536056009038 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 536056009039 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 536056009040 Ligand binding site; other site 536056009041 metal-binding site 536056009042 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 536056009043 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 536056009044 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 536056009045 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 536056009046 putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314 536056009047 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 536056009048 active site 536056009049 putative substrate binding pocket [chemical binding]; other site 536056009050 probable selenate reductase, FAD-binding subunit; Region: Se_sel_red_FAD; TIGR03312 536056009051 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 536056009052 putative hypoxanthine oxidase; Provisional; Region: PRK09800 536056009053 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 536056009054 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 536056009055 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 536056009056 uracil-xanthine permease; Region: ncs2; TIGR00801 536056009057 guanine deaminase; Provisional; Region: PRK09228 536056009058 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 536056009059 active site 536056009060 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 536056009061 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 536056009062 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12809 536056009063 4Fe-4S binding domain; Region: Fer4; pfam00037 536056009064 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 536056009065 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 536056009066 xanthine permease; Region: pbuX; TIGR03173 536056009067 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 536056009068 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 536056009069 active site 536056009070 metal binding site [ion binding]; metal-binding site 536056009071 nudix motif; other site 536056009072 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 536056009073 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 536056009074 dimer interface [polypeptide binding]; other site 536056009075 putative anticodon binding site; other site 536056009076 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 536056009077 motif 1; other site 536056009078 active site 536056009079 motif 2; other site 536056009080 motif 3; other site 536056009081 peptide chain release factor 2; Validated; Region: prfB; PRK00578 536056009082 This domain is found in peptide chain release factors; Region: PCRF; smart00937 536056009083 RF-1 domain; Region: RF-1; pfam00472 536056009084 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 536056009085 DHH family; Region: DHH; pfam01368 536056009086 DHHA1 domain; Region: DHHA1; pfam02272 536056009087 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 536056009088 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 536056009089 dimerization domain [polypeptide binding]; other site 536056009090 dimer interface [polypeptide binding]; other site 536056009091 catalytic residues [active] 536056009092 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 536056009093 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 536056009094 active site 536056009095 Int/Topo IB signature motif; other site 536056009096 flavodoxin FldB; Provisional; Region: PRK12359 536056009097 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 536056009098 hypothetical protein; Provisional; Region: PRK10878 536056009099 putative global regulator; Reviewed; Region: PRK09559 536056009100 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 536056009101 hemolysin; Provisional; Region: PRK15087 536056009102 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 536056009103 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 536056009104 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 536056009105 beta-galactosidase; Region: BGL; TIGR03356 536056009106 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 536056009107 classical (c) SDRs; Region: SDR_c; cd05233 536056009108 NAD(P) binding site [chemical binding]; other site 536056009109 active site 536056009110 glycine dehydrogenase; Provisional; Region: PRK05367 536056009111 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 536056009112 tetramer interface [polypeptide binding]; other site 536056009113 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056009114 catalytic residue [active] 536056009115 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 536056009116 tetramer interface [polypeptide binding]; other site 536056009117 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056009118 catalytic residue [active] 536056009119 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 536056009120 lipoyl attachment site [posttranslational modification]; other site 536056009121 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 536056009122 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 536056009123 oxidoreductase; Provisional; Region: PRK08013 536056009124 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 536056009125 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 536056009126 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 536056009127 proline aminopeptidase P II; Provisional; Region: PRK10879 536056009128 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 536056009129 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 536056009130 active site 536056009131 hypothetical protein; Reviewed; Region: PRK01736 536056009132 Z-ring-associated protein; Provisional; Region: PRK10972 536056009133 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 536056009134 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 536056009135 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 536056009136 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 536056009137 ligand binding site [chemical binding]; other site 536056009138 NAD binding site [chemical binding]; other site 536056009139 tetramer interface [polypeptide binding]; other site 536056009140 catalytic site [active] 536056009141 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 536056009142 L-serine binding site [chemical binding]; other site 536056009143 ACT domain interface; other site 536056009144 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 536056009145 tetramer (dimer of dimers) interface [polypeptide binding]; other site 536056009146 active site 536056009147 dimer interface [polypeptide binding]; other site 536056009148 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 536056009149 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 536056009150 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056009151 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 536056009152 putative dimerization interface [polypeptide binding]; other site 536056009153 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 536056009154 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 536056009155 active site 536056009156 substrate binding site [chemical binding]; other site 536056009157 coenzyme B12 binding site [chemical binding]; other site 536056009158 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 536056009159 B12 binding site [chemical binding]; other site 536056009160 cobalt ligand [ion binding]; other site 536056009161 membrane ATPase/protein kinase; Provisional; Region: PRK09435 536056009162 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 536056009163 Walker A; other site 536056009164 methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423 536056009165 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 536056009166 substrate binding site [chemical binding]; other site 536056009167 oxyanion hole (OAH) forming residues; other site 536056009168 trimer interface [polypeptide binding]; other site 536056009169 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 536056009170 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 536056009171 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 536056009172 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056009173 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536056009174 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 536056009175 dimerization interface [polypeptide binding]; other site 536056009176 Uncharacterized conserved protein [Function unknown]; Region: COG2968 536056009177 oxidative stress defense protein; Provisional; Region: PRK11087 536056009178 arginine exporter protein; Provisional; Region: PRK09304 536056009179 mechanosensitive channel MscS; Provisional; Region: PRK10334 536056009180 Mechanosensitive ion channel; Region: MS_channel; pfam00924 536056009181 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 536056009182 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 536056009183 active site 536056009184 intersubunit interface [polypeptide binding]; other site 536056009185 zinc binding site [ion binding]; other site 536056009186 Na+ binding site [ion binding]; other site 536056009187 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 536056009188 Phosphoglycerate kinase; Region: PGK; pfam00162 536056009189 substrate binding site [chemical binding]; other site 536056009190 hinge regions; other site 536056009191 ADP binding site [chemical binding]; other site 536056009192 catalytic site [active] 536056009193 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 536056009194 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 536056009195 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 536056009196 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 536056009197 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 536056009198 active site 536056009199 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 536056009200 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 536056009201 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 536056009202 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 536056009203 putative active site [active] 536056009204 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 536056009205 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 536056009206 putative NAD(P) binding site [chemical binding]; other site 536056009207 catalytic Zn binding site [ion binding]; other site 536056009208 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 536056009209 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 536056009210 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 536056009211 active site 536056009212 P-loop; other site 536056009213 phosphorylation site [posttranslational modification] 536056009214 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 536056009215 active site 536056009216 phosphorylation site [posttranslational modification] 536056009217 transketolase; Reviewed; Region: PRK12753 536056009218 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 536056009219 TPP-binding site [chemical binding]; other site 536056009220 dimer interface [polypeptide binding]; other site 536056009221 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 536056009222 PYR/PP interface [polypeptide binding]; other site 536056009223 dimer interface [polypeptide binding]; other site 536056009224 TPP binding site [chemical binding]; other site 536056009225 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 536056009226 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 536056009227 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 536056009228 agmatinase; Region: agmatinase; TIGR01230 536056009229 oligomer interface [polypeptide binding]; other site 536056009230 putative active site [active] 536056009231 Mn binding site [ion binding]; other site 536056009232 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 536056009233 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 536056009234 dimer interface [polypeptide binding]; other site 536056009235 active site 536056009236 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 536056009237 catalytic residues [active] 536056009238 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 536056009239 Virulence promoting factor; Region: YqgB; pfam11036 536056009240 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 536056009241 S-adenosylmethionine synthetase; Validated; Region: PRK05250 536056009242 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 536056009243 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 536056009244 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 536056009245 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 536056009246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056009247 putative substrate translocation pore; other site 536056009248 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056009249 hypothetical protein; Provisional; Region: PRK04860 536056009250 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 536056009251 DNA-specific endonuclease I; Provisional; Region: PRK15137 536056009252 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 536056009253 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 536056009254 RNA methyltransferase, RsmE family; Region: TIGR00046 536056009255 glutathione synthetase; Provisional; Region: PRK05246 536056009256 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 536056009257 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 536056009258 hypothetical protein; Validated; Region: PRK00228 536056009259 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 536056009260 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 536056009261 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 536056009262 Walker A motif; other site 536056009263 ATP binding site [chemical binding]; other site 536056009264 Walker B motif; other site 536056009265 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 536056009266 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 536056009267 catalytic residue [active] 536056009268 YGGT family; Region: YGGT; pfam02325 536056009269 YGGT family; Region: YGGT; pfam02325 536056009270 hypothetical protein; Validated; Region: PRK05090 536056009271 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 536056009272 active site 536056009273 dimerization interface [polypeptide binding]; other site 536056009274 HemN family oxidoreductase; Provisional; Region: PRK05660 536056009275 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 536056009276 FeS/SAM binding site; other site 536056009277 HemN C-terminal domain; Region: HemN_C; pfam06969 536056009278 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 536056009279 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 536056009280 homodimer interface [polypeptide binding]; other site 536056009281 active site 536056009282 hypothetical protein; Provisional; Region: PRK10626 536056009283 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 536056009284 hypothetical protein; Provisional; Region: PRK11702 536056009285 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 536056009286 adenine DNA glycosylase; Provisional; Region: PRK10880 536056009287 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 536056009288 minor groove reading motif; other site 536056009289 helix-hairpin-helix signature motif; other site 536056009290 substrate binding pocket [chemical binding]; other site 536056009291 active site 536056009292 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 536056009293 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 536056009294 DNA binding and oxoG recognition site [nucleotide binding] 536056009295 oxidative damage protection protein; Provisional; Region: PRK05408 536056009296 murein transglycosylase C; Provisional; Region: mltC; PRK11671 536056009297 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 536056009298 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 536056009299 N-acetyl-D-glucosamine binding site [chemical binding]; other site 536056009300 catalytic residue [active] 536056009301 nucleoside transporter; Region: 2A0110; TIGR00889 536056009302 ornithine decarboxylase; Provisional; Region: PRK13578 536056009303 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 536056009304 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 536056009305 homodimer interface [polypeptide binding]; other site 536056009306 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056009307 catalytic residue [active] 536056009308 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 536056009309 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 536056009310 putative general secretion pathway protein YghD; Provisional; Region: PRK09731 536056009311 GspL-like protein; Provisional; Region: PRK09662 536056009312 putative type II secretion protein GspC; Provisional; Region: PRK09681 536056009313 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 536056009314 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 536056009315 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 536056009316 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 536056009317 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 536056009318 Domain of unknown function (DUF4092); Region: DUF4092; pfam13322 536056009319 Peptidase M60-like family; Region: M60-like; pfam13402 536056009320 glycolate transporter; Provisional; Region: PRK09695 536056009321 L-lactate permease; Region: Lactate_perm; cl00701 536056009322 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 536056009323 active site 536056009324 hypothetical protein; Provisional; Region: PRK09732 536056009325 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 536056009326 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 536056009327 Cysteine-rich domain; Region: CCG; pfam02754 536056009328 Cysteine-rich domain; Region: CCG; pfam02754 536056009329 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 536056009330 FAD binding domain; Region: FAD_binding_4; pfam01565 536056009331 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 536056009332 FAD binding domain; Region: FAD_binding_4; pfam01565 536056009333 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 536056009334 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536056009335 DNA-binding site [nucleotide binding]; DNA binding site 536056009336 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 536056009337 Transposase domain (DUF772); Region: DUF772; pfam05598 536056009338 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 536056009339 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 536056009340 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 536056009341 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 536056009342 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 536056009343 Thymidylate kinase; Region: Thymidylate_kin; pfam02223 536056009344 active site 536056009345 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 536056009346 TMP-binding site; other site 536056009347 ATP-binding site [chemical binding]; other site 536056009348 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 536056009349 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 536056009350 TMP-binding site; other site 536056009351 ATP-binding site [chemical binding]; other site 536056009352 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 536056009353 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 536056009354 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 536056009355 CHAP domain; Region: CHAP; pfam05257 536056009356 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 536056009357 putative S-transferase; Provisional; Region: PRK11752 536056009358 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 536056009359 C-terminal domain interface [polypeptide binding]; other site 536056009360 GSH binding site (G-site) [chemical binding]; other site 536056009361 dimer interface [polypeptide binding]; other site 536056009362 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 536056009363 dimer interface [polypeptide binding]; other site 536056009364 N-terminal domain interface [polypeptide binding]; other site 536056009365 active site 536056009366 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 536056009367 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 536056009368 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 536056009369 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 536056009370 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 536056009371 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 536056009372 putative substrate-binding site; other site 536056009373 nickel binding site [ion binding]; other site 536056009374 hydrogenase 2 large subunit; Provisional; Region: PRK10467 536056009375 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 536056009376 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 536056009377 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 536056009378 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 536056009379 4Fe-4S binding domain; Region: Fer4_6; pfam12837 536056009380 hydrogenase 2 small subunit; Provisional; Region: PRK10468 536056009381 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 536056009382 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 536056009383 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 536056009384 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 536056009385 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 536056009386 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 536056009387 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 536056009388 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 536056009389 active site 536056009390 catalytic tetrad [active] 536056009391 hypothetical protein; Provisional; Region: PRK05208 536056009392 oxidoreductase; Provisional; Region: PRK07985 536056009393 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 536056009394 NAD binding site [chemical binding]; other site 536056009395 metal binding site [ion binding]; metal-binding site 536056009396 active site 536056009397 biopolymer transport protein ExbD; Provisional; Region: PRK11267 536056009398 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 536056009399 biopolymer transport protein ExbB; Provisional; Region: PRK10414 536056009400 cystathionine beta-lyase; Provisional; Region: PRK08114 536056009401 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 536056009402 homodimer interface [polypeptide binding]; other site 536056009403 substrate-cofactor binding pocket; other site 536056009404 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056009405 catalytic residue [active] 536056009406 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 536056009407 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 536056009408 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 536056009409 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 536056009410 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536056009411 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536056009412 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 536056009413 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 536056009414 dimer interface [polypeptide binding]; other site 536056009415 active site 536056009416 metal binding site [ion binding]; metal-binding site 536056009417 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 536056009418 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 536056009419 active site 536056009420 catalytic tetrad [active] 536056009421 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 536056009422 putative outer membrane lipoprotein; Provisional; Region: PRK09973 536056009423 hypothetical protein; Provisional; Region: PRK01254 536056009424 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 536056009425 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 536056009426 'function: Putative multicopper oxidases; repressor protein for FtsI, stop codon appeared' 536056009427 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 536056009428 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 536056009429 putative acyl-acceptor binding pocket; other site 536056009430 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 536056009431 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 536056009432 CAP-like domain; other site 536056009433 active site 536056009434 primary dimer interface [polypeptide binding]; other site 536056009435 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 536056009436 putative ABC transporter periplasmic-binding protein; Provisional; Region: PRK09755 536056009437 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 536056009438 peptide binding site [polypeptide binding]; other site 536056009439 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 536056009440 toxin interface [polypeptide binding]; other site 536056009441 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 536056009442 Zn binding site [ion binding]; other site 536056009443 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536056009444 non-specific DNA binding site [nucleotide binding]; other site 536056009445 salt bridge; other site 536056009446 sequence-specific DNA binding site [nucleotide binding]; other site 536056009447 Motility quorum-sensing regulator (MqsR); Region: MqsR; cd12869 536056009448 peptide binding site [polypeptide binding]; other site 536056009449 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 536056009450 TIGR00156 family protein; Region: TIGR00156 536056009451 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 536056009452 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536056009453 active site 536056009454 phosphorylation site [posttranslational modification] 536056009455 intermolecular recognition site; other site 536056009456 dimerization interface [polypeptide binding]; other site 536056009457 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 536056009458 DNA binding site [nucleotide binding] 536056009459 sensor protein QseC; Provisional; Region: PRK10337 536056009460 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536056009461 dimer interface [polypeptide binding]; other site 536056009462 phosphorylation site [posttranslational modification] 536056009463 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536056009464 ATP binding site [chemical binding]; other site 536056009465 Mg2+ binding site [ion binding]; other site 536056009466 G-X-G motif; other site 536056009467 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 536056009468 Uncharacterized conserved protein [Function unknown]; Region: COG1359 536056009469 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 536056009470 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536056009471 ATP binding site [chemical binding]; other site 536056009472 Mg2+ binding site [ion binding]; other site 536056009473 G-X-G motif; other site 536056009474 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 536056009475 anchoring element; other site 536056009476 dimer interface [polypeptide binding]; other site 536056009477 ATP binding site [chemical binding]; other site 536056009478 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 536056009479 active site 536056009480 metal binding site [ion binding]; metal-binding site 536056009481 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 536056009482 esterase YqiA; Provisional; Region: PRK11071 536056009483 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 536056009484 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 536056009485 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 536056009486 active site 536056009487 metal binding site [ion binding]; metal-binding site 536056009488 hexamer interface [polypeptide binding]; other site 536056009489 putative dehydrogenase; Provisional; Region: PRK11039 536056009490 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 536056009491 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 536056009492 dimer interface [polypeptide binding]; other site 536056009493 ADP-ribose binding site [chemical binding]; other site 536056009494 active site 536056009495 nudix motif; other site 536056009496 metal binding site [ion binding]; metal-binding site 536056009497 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 536056009498 hypothetical protein; Provisional; Region: PRK11653 536056009499 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 536056009500 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 536056009501 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 536056009502 putative active site [active] 536056009503 metal binding site [ion binding]; metal-binding site 536056009504 zinc transporter ZupT; Provisional; Region: PRK04201 536056009505 ZIP Zinc transporter; Region: Zip; pfam02535 536056009506 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 536056009507 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 536056009508 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 536056009509 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 536056009510 putative fimbrial protein; Provisional; Region: PRK09733 536056009511 IS2 repressor TnpA; Reviewed; Region: PRK09413 536056009512 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 536056009513 IS2 transposase TnpB; Reviewed; Region: PRK09409 536056009514 HTH-like domain; Region: HTH_21; pfam13276 536056009515 Integrase core domain; Region: rve; pfam00665 536056009516 Integrase core domain; Region: rve_3; pfam13683 536056009517 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 536056009518 PapC N-terminal domain; Region: PapC_N; pfam13954 536056009519 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 536056009520 PapC C-terminal domain; Region: PapC_C; pfam13953 536056009521 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 536056009522 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 536056009523 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 536056009524 Fimbrial protein; Region: Fimbrial; pfam00419 536056009525 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 536056009526 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 536056009527 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 536056009528 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 536056009529 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 536056009530 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 536056009531 putative ribose interaction site [chemical binding]; other site 536056009532 putative ADP binding site [chemical binding]; other site 536056009533 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 536056009534 active site 536056009535 nucleotide binding site [chemical binding]; other site 536056009536 HIGH motif; other site 536056009537 KMSKS motif; other site 536056009538 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 536056009539 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 536056009540 metal binding triad; other site 536056009541 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 536056009542 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 536056009543 metal binding triad; other site 536056009544 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 536056009545 Uncharacterized conserved protein [Function unknown]; Region: COG3025 536056009546 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 536056009547 putative active site [active] 536056009548 putative metal binding residues [ion binding]; other site 536056009549 signature motif; other site 536056009550 putative triphosphate binding site [ion binding]; other site 536056009551 CHAD domain; Region: CHAD; pfam05235 536056009552 SH3 domain-containing protein; Provisional; Region: PRK10884 536056009553 Bacterial SH3 domain homologues; Region: SH3b; smart00287 536056009554 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 536056009555 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 536056009556 active site 536056009557 NTP binding site [chemical binding]; other site 536056009558 metal binding triad [ion binding]; metal-binding site 536056009559 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 536056009560 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 536056009561 Zn2+ binding site [ion binding]; other site 536056009562 Mg2+ binding site [ion binding]; other site 536056009563 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 536056009564 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 536056009565 homooctamer interface [polypeptide binding]; other site 536056009566 active site 536056009567 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 536056009568 transcriptional activator TtdR; Provisional; Region: PRK09801 536056009569 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056009570 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 536056009571 putative effector binding pocket; other site 536056009572 putative dimerization interface [polypeptide binding]; other site 536056009573 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 536056009574 'L-tartrate dehydratase, beta subunit, stop codon appeared' 536056009575 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 536056009576 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 536056009577 transmembrane helices; other site 536056009578 UGMP family protein; Validated; Region: PRK09604 536056009579 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 536056009580 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 536056009581 DNA primase; Validated; Region: dnaG; PRK05667 536056009582 CHC2 zinc finger; Region: zf-CHC2; pfam01807 536056009583 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 536056009584 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 536056009585 active site 536056009586 metal binding site [ion binding]; metal-binding site 536056009587 interdomain interaction site; other site 536056009588 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 536056009589 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 536056009590 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 536056009591 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 536056009592 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 536056009593 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 536056009594 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 536056009595 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 536056009596 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 536056009597 DNA binding residues [nucleotide binding] 536056009598 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 536056009599 active site 536056009600 SUMO-1 interface [polypeptide binding]; other site 536056009601 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 536056009602 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 536056009603 FAD binding pocket [chemical binding]; other site 536056009604 FAD binding motif [chemical binding]; other site 536056009605 phosphate binding motif [ion binding]; other site 536056009606 NAD binding pocket [chemical binding]; other site 536056009607 Predicted transcriptional regulators [Transcription]; Region: COG1695 536056009608 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 536056009609 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536056009610 PAS fold; Region: PAS_3; pfam08447 536056009611 putative active site [active] 536056009612 heme pocket [chemical binding]; other site 536056009613 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 536056009614 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 536056009615 dimer interface [polypeptide binding]; other site 536056009616 putative CheW interface [polypeptide binding]; other site 536056009617 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 536056009618 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 536056009619 inhibitor-cofactor binding pocket; inhibition site 536056009620 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056009621 catalytic residue [active] 536056009622 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 536056009623 dimer interface [polypeptide binding]; other site 536056009624 putative tRNA-binding site [nucleotide binding]; other site 536056009625 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 536056009626 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 536056009627 DNA binding site [nucleotide binding] 536056009628 domain linker motif; other site 536056009629 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 536056009630 putative dimerization interface [polypeptide binding]; other site 536056009631 putative ligand binding site [chemical binding]; other site 536056009632 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 536056009633 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 536056009634 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 536056009635 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 536056009636 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 536056009637 cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202 536056009638 inner membrane transporter YjeM; Provisional; Region: PRK15238 536056009639 alpha-glucosidase; Provisional; Region: PRK10137 536056009640 Protein of unknown function, DUF608; Region: DUF608; pfam04685 536056009641 Trehalase; Region: Trehalase; cl17346 536056009642 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 536056009643 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 536056009644 active site 536056009645 FMN binding site [chemical binding]; other site 536056009646 2,4-decadienoyl-CoA binding site; other site 536056009647 catalytic residue [active] 536056009648 4Fe-4S cluster binding site [ion binding]; other site 536056009649 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 536056009650 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536056009651 non-specific DNA binding site [nucleotide binding]; other site 536056009652 salt bridge; other site 536056009653 sequence-specific DNA binding site [nucleotide binding]; other site 536056009654 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680 536056009655 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 536056009656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536056009657 S-adenosylmethionine binding site [chemical binding]; other site 536056009658 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 536056009659 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 536056009660 putative active site [active] 536056009661 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 536056009662 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 536056009663 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 536056009664 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 536056009665 serine/threonine transporter SstT; Provisional; Region: PRK13628 536056009666 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 536056009667 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 536056009668 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 536056009669 galactarate dehydratase; Region: galactar-dH20; TIGR03248 536056009670 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 536056009671 Glucuronate isomerase; Region: UxaC; pfam02614 536056009672 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 536056009673 D-galactonate transporter; Region: 2A0114; TIGR00893 536056009674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056009675 putative substrate translocation pore; other site 536056009676 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 536056009677 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536056009678 DNA-binding site [nucleotide binding]; DNA binding site 536056009679 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 536056009680 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 536056009681 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 536056009682 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 536056009683 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 536056009684 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 536056009685 Predicted membrane protein [Function unknown]; Region: COG5393 536056009686 YqjK-like protein; Region: YqjK; pfam13997 536056009687 Predicted membrane protein [Function unknown]; Region: COG2259 536056009688 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 536056009689 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 536056009690 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 536056009691 putative dimer interface [polypeptide binding]; other site 536056009692 N-terminal domain interface [polypeptide binding]; other site 536056009693 putative substrate binding pocket (H-site) [chemical binding]; other site 536056009694 Predicted membrane protein [Function unknown]; Region: COG3152 536056009695 Predicted membrane protein [Function unknown]; Region: COG3152 536056009696 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056009697 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 536056009698 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 536056009699 dimerization interface [polypeptide binding]; other site 536056009700 Pirin-related protein [General function prediction only]; Region: COG1741 536056009701 Pirin; Region: Pirin; pfam02678 536056009702 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 536056009703 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 536056009704 serine transporter; Region: stp; TIGR00814 536056009705 L-serine dehydratase TdcG; Provisional; Region: PRK15040 536056009706 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 536056009707 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 536056009708 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 536056009709 homotrimer interaction site [polypeptide binding]; other site 536056009710 putative active site [active] 536056009711 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 536056009712 Pyruvate formate lyase 1; Region: PFL1; cd01678 536056009713 coenzyme A binding site [chemical binding]; other site 536056009714 active site 536056009715 catalytic residues [active] 536056009716 glycine loop; other site 536056009717 propionate/acetate kinase; Provisional; Region: PRK12379 536056009718 Acetokinase family; Region: Acetate_kinase; cl17229 536056009719 threonine/serine transporter TdcC; Provisional; Region: PRK13629 536056009720 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 536056009721 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 536056009722 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 536056009723 tetramer interface [polypeptide binding]; other site 536056009724 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056009725 catalytic residue [active] 536056009726 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 536056009727 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056009728 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 536056009729 putative substrate binding pocket [chemical binding]; other site 536056009730 putative dimerization interface [polypeptide binding]; other site 536056009731 DNA-binding transcriptional activator TdcR; Provisional; Region: PRK11424 536056009732 hypothetical protein; Provisional; Region: PRK09716 536056009733 glycerate kinase I; Provisional; Region: PRK10342 536056009734 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 536056009735 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 536056009736 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 536056009737 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056009738 D-galactonate transporter; Region: 2A0114; TIGR00893 536056009739 putative substrate translocation pore; other site 536056009740 galactarate dehydratase; Region: galactar-dH20; TIGR03248 536056009741 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 536056009742 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 536056009743 putative regulator PrlF; Provisional; Region: PRK09974 536056009744 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 536056009745 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 536056009746 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 536056009747 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 536056009748 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 536056009749 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 536056009750 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 536056009751 active site 536056009752 phosphorylation site [posttranslational modification] 536056009753 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 536056009754 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 536056009755 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 536056009756 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 536056009757 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 536056009758 dimer interface [polypeptide binding]; other site 536056009759 active site 536056009760 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 536056009761 putative active site [active] 536056009762 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cd00453 536056009763 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 536056009764 active site 536056009765 intersubunit interface [polypeptide binding]; other site 536056009766 zinc binding site [ion binding]; other site 536056009767 Na+ binding site [ion binding]; other site 536056009768 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 536056009769 active site 536056009770 phosphorylation site [posttranslational modification] 536056009771 PTS system N-acetylgalactosamine-specific transporter subunit IIC; Provisional; Region: PRK09757 536056009772 PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855 536056009773 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 536056009774 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 536056009775 active site 536056009776 trimer interface [polypeptide binding]; other site 536056009777 allosteric site; other site 536056009778 active site lid [active] 536056009779 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 536056009780 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 536056009781 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 536056009782 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 536056009783 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 536056009784 PapC N-terminal domain; Region: PapC_N; pfam13954 536056009785 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 536056009786 PapC C-terminal domain; Region: PapC_C; pfam13953 536056009787 Fimbrial protein; Region: Fimbrial; pfam00419 536056009788 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 536056009789 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 536056009790 putative SAM binding site [chemical binding]; other site 536056009791 putative homodimer interface [polypeptide binding]; other site 536056009792 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 536056009793 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 536056009794 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 536056009795 putative ligand binding site [chemical binding]; other site 536056009796 TIGR00252 family protein; Region: TIGR00252 536056009797 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 536056009798 dimer interface [polypeptide binding]; other site 536056009799 active site 536056009800 outer membrane lipoprotein; Provisional; Region: PRK11023 536056009801 BON domain; Region: BON; pfam04972 536056009802 BON domain; Region: BON; pfam04972 536056009803 Predicted permease; Region: DUF318; pfam03773 536056009804 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 536056009805 NADH(P)-binding; Region: NAD_binding_10; pfam13460 536056009806 NAD binding site [chemical binding]; other site 536056009807 active site 536056009808 intracellular protease, PfpI family; Region: PfpI; TIGR01382 536056009809 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 536056009810 proposed catalytic triad [active] 536056009811 conserved cys residue [active] 536056009812 hypothetical protein; Provisional; Region: PRK03467 536056009813 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 536056009814 GIY-YIG motif/motif A; other site 536056009815 putative active site [active] 536056009816 putative metal binding site [ion binding]; other site 536056009817 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 536056009818 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536056009819 Coenzyme A binding pocket [chemical binding]; other site 536056009820 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 536056009821 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 536056009822 Peptidase family U32; Region: Peptidase_U32; pfam01136 536056009823 putative protease; Provisional; Region: PRK15447 536056009824 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 536056009825 hypothetical protein; Provisional; Region: PRK10508 536056009826 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 536056009827 tryptophan permease; Provisional; Region: PRK10483 536056009828 aromatic amino acid transport protein; Region: araaP; TIGR00837 536056009829 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 536056009830 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 536056009831 ATP binding site [chemical binding]; other site 536056009832 Mg++ binding site [ion binding]; other site 536056009833 motif III; other site 536056009834 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 536056009835 nucleotide binding region [chemical binding]; other site 536056009836 ATP-binding site [chemical binding]; other site 536056009837 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 536056009838 putative RNA binding site [nucleotide binding]; other site 536056009839 lipoprotein NlpI; Provisional; Region: PRK11189 536056009840 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536056009841 binding surface 536056009842 TPR motif; other site 536056009843 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 536056009844 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 536056009845 RNase E interface [polypeptide binding]; other site 536056009846 trimer interface [polypeptide binding]; other site 536056009847 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 536056009848 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 536056009849 RNase E interface [polypeptide binding]; other site 536056009850 trimer interface [polypeptide binding]; other site 536056009851 active site 536056009852 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 536056009853 putative nucleic acid binding region [nucleotide binding]; other site 536056009854 G-X-X-G motif; other site 536056009855 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 536056009856 RNA binding site [nucleotide binding]; other site 536056009857 domain interface; other site 536056009858 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 536056009859 16S/18S rRNA binding site [nucleotide binding]; other site 536056009860 S13e-L30e interaction site [polypeptide binding]; other site 536056009861 25S rRNA binding site [nucleotide binding]; other site 536056009862 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 536056009863 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 536056009864 RNA binding site [nucleotide binding]; other site 536056009865 active site 536056009866 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 536056009867 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 536056009868 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 536056009869 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 536056009870 translation initiation factor IF-2; Region: IF-2; TIGR00487 536056009871 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 536056009872 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 536056009873 G1 box; other site 536056009874 putative GEF interaction site [polypeptide binding]; other site 536056009875 GTP/Mg2+ binding site [chemical binding]; other site 536056009876 Switch I region; other site 536056009877 G2 box; other site 536056009878 G3 box; other site 536056009879 Switch II region; other site 536056009880 G4 box; other site 536056009881 G5 box; other site 536056009882 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 536056009883 Translation-initiation factor 2; Region: IF-2; pfam11987 536056009884 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 536056009885 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 536056009886 NusA N-terminal domain; Region: NusA_N; pfam08529 536056009887 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 536056009888 RNA binding site [nucleotide binding]; other site 536056009889 homodimer interface [polypeptide binding]; other site 536056009890 NusA-like KH domain; Region: KH_5; pfam13184 536056009891 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 536056009892 G-X-X-G motif; other site 536056009893 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 536056009894 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 536056009895 ribosome maturation protein RimP; Reviewed; Region: PRK00092 536056009896 Sm and related proteins; Region: Sm_like; cl00259 536056009897 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 536056009898 putative oligomer interface [polypeptide binding]; other site 536056009899 putative RNA binding site [nucleotide binding]; other site 536056009900 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 536056009901 ANP binding site [chemical binding]; other site 536056009902 Substrate Binding Site II [chemical binding]; other site 536056009903 Substrate Binding Site I [chemical binding]; other site 536056009904 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 536056009905 Sulfatase; Region: Sulfatase; pfam00884 536056009906 Preprotein translocase SecG subunit; Region: SecG; pfam03840 536056009907 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 536056009908 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 536056009909 active site 536056009910 substrate binding site [chemical binding]; other site 536056009911 metal binding site [ion binding]; metal-binding site 536056009912 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 536056009913 dihydropteroate synthase; Region: DHPS; TIGR01496 536056009914 substrate binding pocket [chemical binding]; other site 536056009915 dimer interface [polypeptide binding]; other site 536056009916 inhibitor binding site; inhibition site 536056009917 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 536056009918 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536056009919 Walker A motif; other site 536056009920 ATP binding site [chemical binding]; other site 536056009921 Walker B motif; other site 536056009922 arginine finger; other site 536056009923 Peptidase family M41; Region: Peptidase_M41; pfam01434 536056009924 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 536056009925 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536056009926 S-adenosylmethionine binding site [chemical binding]; other site 536056009927 RNA-binding protein YhbY; Provisional; Region: PRK10343 536056009928 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 536056009929 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 536056009930 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 536056009931 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 536056009932 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 536056009933 GTPase CgtA; Reviewed; Region: obgE; PRK12298 536056009934 GTP1/OBG; Region: GTP1_OBG; pfam01018 536056009935 Obg GTPase; Region: Obg; cd01898 536056009936 G1 box; other site 536056009937 GTP/Mg2+ binding site [chemical binding]; other site 536056009938 Switch I region; other site 536056009939 G2 box; other site 536056009940 G3 box; other site 536056009941 Switch II region; other site 536056009942 G4 box; other site 536056009943 G5 box; other site 536056009944 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 536056009945 EamA-like transporter family; Region: EamA; pfam00892 536056009946 EamA-like transporter family; Region: EamA; pfam00892 536056009947 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 536056009948 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 536056009949 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 536056009950 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 536056009951 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 536056009952 substrate binding pocket [chemical binding]; other site 536056009953 chain length determination region; other site 536056009954 substrate-Mg2+ binding site; other site 536056009955 catalytic residues [active] 536056009956 aspartate-rich region 1; other site 536056009957 active site lid residues [active] 536056009958 aspartate-rich region 2; other site 536056009959 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 536056009960 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 536056009961 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 536056009962 hinge; other site 536056009963 active site 536056009964 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 536056009965 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 536056009966 anti sigma factor interaction site; other site 536056009967 regulatory phosphorylation site [posttranslational modification]; other site 536056009968 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 536056009969 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 536056009970 mce related protein; Region: MCE; pfam02470 536056009971 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 536056009972 conserved hypothetical integral membrane protein; Region: TIGR00056 536056009973 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 536056009974 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 536056009975 Walker A/P-loop; other site 536056009976 ATP binding site [chemical binding]; other site 536056009977 Q-loop/lid; other site 536056009978 ABC transporter signature motif; other site 536056009979 Walker B; other site 536056009980 D-loop; other site 536056009981 H-loop/switch region; other site 536056009982 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 536056009983 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 536056009984 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 536056009985 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 536056009986 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 536056009987 putative active site [active] 536056009988 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 536056009989 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 536056009990 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 536056009991 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 536056009992 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 536056009993 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 536056009994 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 536056009995 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 536056009996 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 536056009997 Walker A/P-loop; other site 536056009998 ATP binding site [chemical binding]; other site 536056009999 Q-loop/lid; other site 536056010000 ABC transporter signature motif; other site 536056010001 Walker B; other site 536056010002 D-loop; other site 536056010003 H-loop/switch region; other site 536056010004 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 536056010005 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 536056010006 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 536056010007 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 536056010008 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 536056010009 30S subunit binding site; other site 536056010010 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 536056010011 active site 536056010012 phosphorylation site [posttranslational modification] 536056010013 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 536056010014 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 536056010015 dimerization domain swap beta strand [polypeptide binding]; other site 536056010016 regulatory protein interface [polypeptide binding]; other site 536056010017 active site 536056010018 regulatory phosphorylation site [posttranslational modification]; other site 536056010019 hypothetical protein; Provisional; Region: PRK10345 536056010020 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 536056010021 Transglycosylase; Region: Transgly; cl17702 536056010022 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 536056010023 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 536056010024 conserved cys residue [active] 536056010025 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 536056010026 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536056010027 putative active site [active] 536056010028 heme pocket [chemical binding]; other site 536056010029 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536056010030 dimer interface [polypeptide binding]; other site 536056010031 phosphorylation site [posttranslational modification] 536056010032 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536056010033 ATP binding site [chemical binding]; other site 536056010034 Mg2+ binding site [ion binding]; other site 536056010035 G-X-G motif; other site 536056010036 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536056010037 active site 536056010038 phosphorylation site [posttranslational modification] 536056010039 intermolecular recognition site; other site 536056010040 dimerization interface [polypeptide binding]; other site 536056010041 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 536056010042 putative binding surface; other site 536056010043 active site 536056010044 radical SAM protein, TIGR01212 family; Region: TIGR01212 536056010045 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 536056010046 FeS/SAM binding site; other site 536056010047 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 536056010048 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 536056010049 active site 536056010050 dimer interface [polypeptide binding]; other site 536056010051 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 536056010052 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 536056010053 active site 536056010054 FMN binding site [chemical binding]; other site 536056010055 substrate binding site [chemical binding]; other site 536056010056 3Fe-4S cluster binding site [ion binding]; other site 536056010057 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 536056010058 domain interface; other site 536056010059 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 536056010060 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 536056010061 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 536056010062 Protein of unknown function (DUF1120); Region: DUF1120; pfam06551 536056010063 putative fimbrial chaperone protein; Provisional; Region: PRK09918 536056010064 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 536056010065 putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304 536056010066 PapC N-terminal domain; Region: PapC_N; pfam13954 536056010067 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 536056010068 PapC C-terminal domain; Region: PapC_C; pfam13953 536056010069 'pseudogene predicted protein N-ter fragment, pseudogene fragment due to insertion' 536056010070 Transposase domain (DUF772); Region: DUF772; pfam05598 536056010071 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 536056010072 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 536056010073 'pseudogene predicted protein C-ter fragment, pseudogene fragment due to insertion' 536056010074 Protein of unknown function (DUF1120); Region: DUF1120; pfam06551 536056010075 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 536056010076 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 536056010077 uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022 536056010078 N-acetylmannosamine kinase; Provisional; Region: PRK05082 536056010079 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 536056010080 nucleotide binding site [chemical binding]; other site 536056010081 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 536056010082 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 536056010083 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 536056010084 putative active site cavity [active] 536056010085 putative sialic acid transporter; Provisional; Region: PRK03893 536056010086 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056010087 putative substrate translocation pore; other site 536056010088 N-acetylneuraminate lyase; Region: nanA; TIGR00683 536056010089 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 536056010090 inhibitor site; inhibition site 536056010091 active site 536056010092 dimer interface [polypeptide binding]; other site 536056010093 catalytic residue [active] 536056010094 transcriptional regulator NanR; Provisional; Region: PRK03837 536056010095 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536056010096 DNA-binding site [nucleotide binding]; DNA binding site 536056010097 FCD domain; Region: FCD; pfam07729 536056010098 putative cryptic C4-dicarboxylate transporter DcuD; Provisional; Region: PRK09804 536056010099 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 536056010100 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 536056010101 stringent starvation protein A; Provisional; Region: sspA; PRK09481 536056010102 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 536056010103 C-terminal domain interface [polypeptide binding]; other site 536056010104 putative GSH binding site (G-site) [chemical binding]; other site 536056010105 dimer interface [polypeptide binding]; other site 536056010106 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 536056010107 dimer interface [polypeptide binding]; other site 536056010108 N-terminal domain interface [polypeptide binding]; other site 536056010109 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 536056010110 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 536056010111 23S rRNA interface [nucleotide binding]; other site 536056010112 L3 interface [polypeptide binding]; other site 536056010113 Predicted ATPase [General function prediction only]; Region: COG1485 536056010114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 536056010115 hypothetical protein; Provisional; Region: PRK11677 536056010116 serine endoprotease; Provisional; Region: PRK10139 536056010117 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 536056010118 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 536056010119 protein binding site [polypeptide binding]; other site 536056010120 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 536056010121 serine endoprotease; Provisional; Region: PRK10898 536056010122 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 536056010123 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 536056010124 malate dehydrogenase; Provisional; Region: PRK05086 536056010125 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 536056010126 NAD binding site [chemical binding]; other site 536056010127 dimerization interface [polypeptide binding]; other site 536056010128 Substrate binding site [chemical binding]; other site 536056010129 arginine repressor; Provisional; Region: PRK05066 536056010130 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 536056010131 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 536056010132 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 536056010133 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 536056010134 RNAase interaction site [polypeptide binding]; other site 536056010135 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 536056010136 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 536056010137 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 536056010138 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 536056010139 HlyD family secretion protein; Region: HlyD_3; pfam13437 536056010140 efflux system membrane protein; Provisional; Region: PRK11594 536056010141 transcriptional regulator; Provisional; Region: PRK10632 536056010142 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056010143 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 536056010144 putative effector binding pocket; other site 536056010145 dimerization interface [polypeptide binding]; other site 536056010146 protease TldD; Provisional; Region: tldD; PRK10735 536056010147 hypothetical protein; Provisional; Region: PRK10899 536056010148 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 536056010149 ribonuclease G; Provisional; Region: PRK11712 536056010150 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 536056010151 homodimer interface [polypeptide binding]; other site 536056010152 oligonucleotide binding site [chemical binding]; other site 536056010153 Maf-like protein; Region: Maf; pfam02545 536056010154 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 536056010155 active site 536056010156 dimer interface [polypeptide binding]; other site 536056010157 rod shape-determining protein MreD; Provisional; Region: PRK11060 536056010158 rod shape-determining protein MreC; Region: mreC; TIGR00219 536056010159 rod shape-determining protein MreC; Region: MreC; pfam04085 536056010160 rod shape-determining protein MreB; Provisional; Region: PRK13927 536056010161 MreB and similar proteins; Region: MreB_like; cd10225 536056010162 nucleotide binding site [chemical binding]; other site 536056010163 Mg binding site [ion binding]; other site 536056010164 putative protofilament interaction site [polypeptide binding]; other site 536056010165 RodZ interaction site [polypeptide binding]; other site 536056010166 regulatory protein CsrD; Provisional; Region: PRK11059 536056010167 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 536056010168 metal binding site [ion binding]; metal-binding site 536056010169 active site 536056010170 I-site; other site 536056010171 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 536056010172 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 536056010173 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 536056010174 NADP binding site [chemical binding]; other site 536056010175 dimer interface [polypeptide binding]; other site 536056010176 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 536056010177 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 536056010178 carboxyltransferase (CT) interaction site; other site 536056010179 biotinylation site [posttranslational modification]; other site 536056010180 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 536056010181 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 536056010182 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 536056010183 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 536056010184 hypothetical protein; Provisional; Region: PRK10633 536056010185 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 536056010186 Na binding site [ion binding]; other site 536056010187 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 536056010188 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 536056010189 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 536056010190 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 536056010191 FMN binding site [chemical binding]; other site 536056010192 active site 536056010193 catalytic residues [active] 536056010194 substrate binding site [chemical binding]; other site 536056010195 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 536056010196 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 536056010197 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 536056010198 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536056010199 DNA methylase; Region: N6_N4_Mtase; pfam01555 536056010200 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 536056010201 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 536056010202 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536056010203 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 536056010204 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 536056010205 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 536056010206 HlyD family secretion protein; Region: HlyD_3; pfam13437 536056010207 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 536056010208 Protein export membrane protein; Region: SecD_SecF; cl14618 536056010209 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 536056010210 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 536056010211 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536056010212 substrate binding pocket [chemical binding]; other site 536056010213 membrane-bound complex binding site; other site 536056010214 hinge residues; other site 536056010215 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 536056010216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056010217 conserved gate region; other site 536056010218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056010219 dimer interface [polypeptide binding]; other site 536056010220 conserved gate region; other site 536056010221 putative PBP binding loops; other site 536056010222 ABC-ATPase subunit interface; other site 536056010223 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 536056010224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056010225 dimer interface [polypeptide binding]; other site 536056010226 conserved gate region; other site 536056010227 putative PBP binding loops; other site 536056010228 ABC-ATPase subunit interface; other site 536056010229 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 536056010230 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 536056010231 Walker A/P-loop; other site 536056010232 ATP binding site [chemical binding]; other site 536056010233 Q-loop/lid; other site 536056010234 ABC transporter signature motif; other site 536056010235 Walker B; other site 536056010236 D-loop; other site 536056010237 H-loop/switch region; other site 536056010238 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 536056010239 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 536056010240 trimer interface [polypeptide binding]; other site 536056010241 putative metal binding site [ion binding]; other site 536056010242 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 536056010243 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 536056010244 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 536056010245 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 536056010246 shikimate binding site; other site 536056010247 NAD(P) binding site [chemical binding]; other site 536056010248 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 536056010249 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 536056010250 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 536056010251 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 536056010252 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 536056010253 hypothetical protein; Validated; Region: PRK03430 536056010254 hypothetical protein; Provisional; Region: PRK10736 536056010255 DNA protecting protein DprA; Region: dprA; TIGR00732 536056010256 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 536056010257 active site 536056010258 catalytic residues [active] 536056010259 metal binding site [ion binding]; metal-binding site 536056010260 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 536056010261 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 536056010262 putative active site [active] 536056010263 substrate binding site [chemical binding]; other site 536056010264 putative cosubstrate binding site; other site 536056010265 catalytic site [active] 536056010266 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 536056010267 substrate binding site [chemical binding]; other site 536056010268 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 536056010269 putative RNA binding site [nucleotide binding]; other site 536056010270 16S rRNA methyltransferase B; Provisional; Region: PRK10901 536056010271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536056010272 S-adenosylmethionine binding site [chemical binding]; other site 536056010273 'Trk system potassium uptake protein trkA(K(+)-uptake protein trkA), stop codon appeared; function: K+ transport systems, NAD-binding component' 536056010274 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 536056010275 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 536056010276 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 536056010277 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 536056010278 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 536056010279 DNA binding residues [nucleotide binding] 536056010280 dimer interface [polypeptide binding]; other site 536056010281 metal binding site [ion binding]; metal-binding site 536056010282 hypothetical protein; Provisional; Region: PRK10203 536056010283 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 536056010284 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 536056010285 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 536056010286 alphaNTD homodimer interface [polypeptide binding]; other site 536056010287 alphaNTD - beta interaction site [polypeptide binding]; other site 536056010288 alphaNTD - beta' interaction site [polypeptide binding]; other site 536056010289 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 536056010290 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 536056010291 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 536056010292 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 536056010293 RNA binding surface [nucleotide binding]; other site 536056010294 30S ribosomal protein S11; Validated; Region: PRK05309 536056010295 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 536056010296 30S ribosomal protein S13; Region: bact_S13; TIGR03631 536056010297 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 536056010298 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 536056010299 SecY translocase; Region: SecY; pfam00344 536056010300 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 536056010301 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 536056010302 23S rRNA binding site [nucleotide binding]; other site 536056010303 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 536056010304 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 536056010305 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 536056010306 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 536056010307 23S rRNA interface [nucleotide binding]; other site 536056010308 5S rRNA interface [nucleotide binding]; other site 536056010309 L27 interface [polypeptide binding]; other site 536056010310 L5 interface [polypeptide binding]; other site 536056010311 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 536056010312 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 536056010313 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 536056010314 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 536056010315 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 536056010316 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 536056010317 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 536056010318 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 536056010319 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 536056010320 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 536056010321 RNA binding site [nucleotide binding]; other site 536056010322 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 536056010323 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 536056010324 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 536056010325 23S rRNA interface [nucleotide binding]; other site 536056010326 putative translocon interaction site; other site 536056010327 signal recognition particle (SRP54) interaction site; other site 536056010328 L23 interface [polypeptide binding]; other site 536056010329 trigger factor interaction site; other site 536056010330 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 536056010331 23S rRNA interface [nucleotide binding]; other site 536056010332 5S rRNA interface [nucleotide binding]; other site 536056010333 putative antibiotic binding site [chemical binding]; other site 536056010334 L25 interface [polypeptide binding]; other site 536056010335 L27 interface [polypeptide binding]; other site 536056010336 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 536056010337 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 536056010338 G-X-X-G motif; other site 536056010339 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 536056010340 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 536056010341 protein-rRNA interface [nucleotide binding]; other site 536056010342 putative translocon binding site; other site 536056010343 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 536056010344 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 536056010345 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 536056010346 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 536056010347 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 536056010348 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 536056010349 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 536056010350 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 536056010351 protein secretion protein GspB; Provisional; Region: PRK09697 536056010352 AAA domain; Region: AAA_22; pfam13401 536056010353 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 536056010354 Type II secretory pathway, component PulC [Intracellular trafficking and secretion]; Region: PulC; COG3031 536056010355 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 536056010356 type II secretion system protein D; Region: type_II_gspD; TIGR02517 536056010357 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 536056010358 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 536056010359 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 536056010360 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 536056010361 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 536056010362 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 536056010363 Walker A motif; other site 536056010364 ATP binding site [chemical binding]; other site 536056010365 Walker B motif; other site 536056010366 type II secretion system protein F; Region: GspF; TIGR02120 536056010367 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 536056010368 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 536056010369 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 536056010370 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 536056010371 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 536056010372 type II secretion system protein I; Region: gspI; TIGR01707 536056010373 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 536056010374 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 536056010375 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 536056010376 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 536056010377 Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156 536056010378 Type II secretory pathway, component PulL [Intracellular trafficking and secretion]; Region: PulL; COG3297 536056010379 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 536056010380 GspL periplasmic domain; Region: GspL_C; pfam12693 536056010381 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 536056010382 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 536056010383 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 536056010384 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 536056010385 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 536056010386 heme binding site [chemical binding]; other site 536056010387 ferroxidase pore; other site 536056010388 ferroxidase diiron center [ion binding]; other site 536056010389 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 536056010390 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 536056010391 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 536056010392 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 536056010393 aromatic chitin/cellulose binding site residues [chemical binding]; other site 536056010394 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 536056010395 active site 536056010396 elongation factor Tu; Reviewed; Region: PRK00049 536056010397 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 536056010398 G1 box; other site 536056010399 GEF interaction site [polypeptide binding]; other site 536056010400 GTP/Mg2+ binding site [chemical binding]; other site 536056010401 Switch I region; other site 536056010402 G2 box; other site 536056010403 G3 box; other site 536056010404 Switch II region; other site 536056010405 G4 box; other site 536056010406 G5 box; other site 536056010407 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 536056010408 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 536056010409 Antibiotic Binding Site [chemical binding]; other site 536056010410 elongation factor G; Reviewed; Region: PRK00007 536056010411 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 536056010412 G1 box; other site 536056010413 putative GEF interaction site [polypeptide binding]; other site 536056010414 GTP/Mg2+ binding site [chemical binding]; other site 536056010415 Switch I region; other site 536056010416 G2 box; other site 536056010417 G3 box; other site 536056010418 Switch II region; other site 536056010419 G4 box; other site 536056010420 G5 box; other site 536056010421 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 536056010422 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 536056010423 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 536056010424 30S ribosomal protein S7; Validated; Region: PRK05302 536056010425 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 536056010426 S17 interaction site [polypeptide binding]; other site 536056010427 S8 interaction site; other site 536056010428 16S rRNA interaction site [nucleotide binding]; other site 536056010429 streptomycin interaction site [chemical binding]; other site 536056010430 23S rRNA interaction site [nucleotide binding]; other site 536056010431 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 536056010432 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 536056010433 sulfur relay protein TusC; Validated; Region: PRK00211 536056010434 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 536056010435 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 536056010436 YheO-like PAS domain; Region: PAS_6; pfam08348 536056010437 HTH domain; Region: HTH_22; pfam13309 536056010438 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 536056010439 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 536056010440 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 536056010441 phi X174 lysis protein; Provisional; Region: PRK02793 536056010442 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 536056010443 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 536056010444 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 536056010445 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 536056010446 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 536056010447 TrkA-N domain; Region: TrkA_N; pfam02254 536056010448 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 536056010449 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 536056010450 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 536056010451 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536056010452 Walker A/P-loop; other site 536056010453 ATP binding site [chemical binding]; other site 536056010454 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 536056010455 ABC transporter signature motif; other site 536056010456 Walker B; other site 536056010457 D-loop; other site 536056010458 ABC transporter; Region: ABC_tran_2; pfam12848 536056010459 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 536056010460 putative hydrolase; Provisional; Region: PRK10985 536056010461 hypothetical protein; Provisional; Region: PRK04966 536056010462 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 536056010463 active site 536056010464 hypothetical protein; Provisional; Region: PRK10738 536056010465 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 536056010466 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 536056010467 ligand binding site [chemical binding]; other site 536056010468 flexible hinge region; other site 536056010469 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 536056010470 putative switch regulator; other site 536056010471 non-specific DNA interactions [nucleotide binding]; other site 536056010472 DNA binding site [nucleotide binding] 536056010473 sequence specific DNA binding site [nucleotide binding]; other site 536056010474 putative cAMP binding site [chemical binding]; other site 536056010475 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 536056010476 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 536056010477 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 536056010478 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 536056010479 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 536056010480 inhibitor-cofactor binding pocket; inhibition site 536056010481 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056010482 catalytic residue [active] 536056010483 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 536056010484 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 536056010485 glutamine binding [chemical binding]; other site 536056010486 catalytic triad [active] 536056010487 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 536056010488 cell filamentation protein Fic; Provisional; Region: PRK10347 536056010489 hypothetical protein; Provisional; Region: PRK10204 536056010490 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 536056010491 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 536056010492 substrate binding site [chemical binding]; other site 536056010493 putative transporter; Provisional; Region: PRK03699 536056010494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056010495 putative substrate translocation pore; other site 536056010496 nitrite reductase subunit NirD; Provisional; Region: PRK14989 536056010497 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 536056010498 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 536056010499 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 536056010500 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 536056010501 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 536056010502 nitrite transporter NirC; Provisional; Region: PRK11562 536056010503 siroheme synthase; Provisional; Region: cysG; PRK10637 536056010504 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 536056010505 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 536056010506 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 536056010507 active site 536056010508 SAM binding site [chemical binding]; other site 536056010509 homodimer interface [polypeptide binding]; other site 536056010510 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 536056010511 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 536056010512 hypothetical protein; Provisional; Region: PHA02764 536056010513 fructoselysine-6-P-deglycase; Provisional; Region: frlB; PRK11382 536056010514 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 536056010515 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 536056010516 dimer interface [polypeptide binding]; other site 536056010517 active site 536056010518 fructoselysine 3-epimerase; Provisional; Region: PRK09856 536056010519 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 536056010520 AP (apurinic/apyrimidinic) site pocket; other site 536056010521 DNA interaction; other site 536056010522 Metal-binding active site; metal-binding site 536056010523 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 536056010524 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 536056010525 substrate binding site [chemical binding]; other site 536056010526 ATP binding site [chemical binding]; other site 536056010527 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 536056010528 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536056010529 DNA-binding site [nucleotide binding]; DNA binding site 536056010530 UTRA domain; Region: UTRA; pfam07702 536056010531 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 536056010532 DNA topoisomerase III, bacteria and conjugative plasmid; Region: topB; TIGR01056 536056010533 Protein of unknown function; Region: YhfT; pfam10797 536056010534 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 536056010535 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 536056010536 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 536056010537 active site 536056010538 substrate binding pocket [chemical binding]; other site 536056010539 homodimer interaction site [polypeptide binding]; other site 536056010540 putative mutase; Provisional; Region: PRK12383 536056010541 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; COG1015 536056010542 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 536056010543 dimer interface [polypeptide binding]; other site 536056010544 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 536056010545 active site 536056010546 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 536056010547 substrate binding site [chemical binding]; other site 536056010548 catalytic residue [active] 536056010549 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 536056010550 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 536056010551 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 536056010552 active site 536056010553 HIGH motif; other site 536056010554 dimer interface [polypeptide binding]; other site 536056010555 KMSKS motif; other site 536056010556 phosphoglycolate phosphatase; Provisional; Region: PRK13222 536056010557 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536056010558 motif II; other site 536056010559 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 536056010560 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 536056010561 substrate binding site [chemical binding]; other site 536056010562 hexamer interface [polypeptide binding]; other site 536056010563 metal binding site [ion binding]; metal-binding site 536056010564 DNA adenine methylase; Provisional; Region: PRK10904 536056010565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 536056010566 cell division protein DamX; Validated; Region: PRK10905 536056010567 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 536056010568 active site 536056010569 dimer interface [polypeptide binding]; other site 536056010570 metal binding site [ion binding]; metal-binding site 536056010571 shikimate kinase; Reviewed; Region: aroK; PRK00131 536056010572 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 536056010573 ADP binding site [chemical binding]; other site 536056010574 magnesium binding site [ion binding]; other site 536056010575 putative shikimate binding site; other site 536056010576 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 536056010577 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 536056010578 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 536056010579 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 536056010580 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 536056010581 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 536056010582 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 536056010583 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 536056010584 Transglycosylase; Region: Transgly; pfam00912 536056010585 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 536056010586 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 536056010587 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 536056010588 ADP-ribose binding site [chemical binding]; other site 536056010589 dimer interface [polypeptide binding]; other site 536056010590 active site 536056010591 nudix motif; other site 536056010592 metal binding site [ion binding]; metal-binding site 536056010593 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 536056010594 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 536056010595 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536056010596 motif II; other site 536056010597 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 536056010598 RNA binding surface [nucleotide binding]; other site 536056010599 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 536056010600 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 536056010601 dimerization interface [polypeptide binding]; other site 536056010602 domain crossover interface; other site 536056010603 redox-dependent activation switch; other site 536056010604 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 536056010605 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 536056010606 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 536056010607 active site 536056010608 substrate-binding site [chemical binding]; other site 536056010609 metal-binding site [ion binding] 536056010610 ATP binding site [chemical binding]; other site 536056010611 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 536056010612 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 536056010613 dimerization interface [polypeptide binding]; other site 536056010614 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536056010615 dimer interface [polypeptide binding]; other site 536056010616 phosphorylation site [posttranslational modification] 536056010617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536056010618 ATP binding site [chemical binding]; other site 536056010619 G-X-G motif; other site 536056010620 osmolarity response regulator; Provisional; Region: ompR; PRK09468 536056010621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536056010622 active site 536056010623 phosphorylation site [posttranslational modification] 536056010624 intermolecular recognition site; other site 536056010625 dimerization interface [polypeptide binding]; other site 536056010626 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 536056010627 DNA binding site [nucleotide binding] 536056010628 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 536056010629 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 536056010630 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 536056010631 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 536056010632 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 536056010633 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 536056010634 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 536056010635 RNA binding site [nucleotide binding]; other site 536056010636 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 536056010637 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 536056010638 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 536056010639 G1 box; other site 536056010640 GTP/Mg2+ binding site [chemical binding]; other site 536056010641 Switch I region; other site 536056010642 G2 box; other site 536056010643 G3 box; other site 536056010644 Switch II region; other site 536056010645 G4 box; other site 536056010646 G5 box; other site 536056010647 Nucleoside recognition; Region: Gate; pfam07670 536056010648 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 536056010649 Nucleoside recognition; Region: Gate; pfam07670 536056010650 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 536056010651 putative transposase; Provisional; Region: PRK09857 536056010652 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 536056010653 carboxylesterase BioH; Provisional; Region: PRK10349 536056010654 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 536056010655 DNA utilization protein GntX; Provisional; Region: PRK11595 536056010656 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 536056010657 active site 536056010658 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 536056010659 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 536056010660 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 536056010661 high-affinity gluconate transporter; Provisional; Region: PRK14984 536056010662 gluconate transporter; Region: gntP; TIGR00791 536056010663 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 536056010664 4-alpha-glucanotransferase; Region: malQ; TIGR00217 536056010665 maltodextrin phosphorylase; Provisional; Region: PRK14985 536056010666 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 536056010667 homodimer interface [polypeptide binding]; other site 536056010668 active site pocket [active] 536056010669 transcriptional regulator MalT; Provisional; Region: PRK04841 536056010670 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536056010671 DNA binding residues [nucleotide binding] 536056010672 dimerization interface [polypeptide binding]; other site 536056010673 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 536056010674 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 536056010675 putative active site [active] 536056010676 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 536056010677 hypothetical protein; Reviewed; Region: PRK09588 536056010678 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 536056010679 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 536056010680 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536056010681 Walker A motif; other site 536056010682 ATP binding site [chemical binding]; other site 536056010683 Walker B motif; other site 536056010684 arginine finger; other site 536056010685 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 536056010686 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 536056010687 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 536056010688 intramembrane serine protease GlpG; Provisional; Region: PRK10907 536056010689 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 536056010690 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 536056010691 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 536056010692 active site residue [active] 536056010693 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 536056010694 glycogen phosphorylase; Provisional; Region: PRK14986 536056010695 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 536056010696 homodimer interface [polypeptide binding]; other site 536056010697 active site pocket [active] 536056010698 glycogen synthase; Provisional; Region: glgA; PRK00654 536056010699 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 536056010700 ADP-binding pocket [chemical binding]; other site 536056010701 homodimer interface [polypeptide binding]; other site 536056010702 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 536056010703 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 536056010704 ligand binding site; other site 536056010705 oligomer interface; other site 536056010706 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 536056010707 sulfate 1 binding site; other site 536056010708 glycogen debranching enzyme; Provisional; Region: PRK03705 536056010709 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 536056010710 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 536056010711 active site 536056010712 catalytic site [active] 536056010713 glycogen branching enzyme; Provisional; Region: PRK05402 536056010714 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 536056010715 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 536056010716 active site 536056010717 catalytic site [active] 536056010718 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 536056010719 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 536056010720 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 536056010721 putative antibiotic transporter; Provisional; Region: PRK10739 536056010722 low affinity gluconate transporter; Provisional; Region: PRK10472 536056010723 gluconate transporter; Region: gntP; TIGR00791 536056010724 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 536056010725 ATP-binding site [chemical binding]; other site 536056010726 Gluconate-6-phosphate binding site [chemical binding]; other site 536056010727 Shikimate kinase; Region: SKI; pfam01202 536056010728 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 536056010729 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 536056010730 DNA binding site [nucleotide binding] 536056010731 domain linker motif; other site 536056010732 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 536056010733 putative ligand binding site [chemical binding]; other site 536056010734 putative dimerization interface [polypeptide binding]; other site 536056010735 Pirin-related protein [General function prediction only]; Region: COG1741 536056010736 Pirin; Region: Pirin; pfam02678 536056010737 putative oxidoreductase; Provisional; Region: PRK10206 536056010738 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 536056010739 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 536056010740 putative acetyltransferase YhhY; Provisional; Region: PRK10140 536056010741 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536056010742 Coenzyme A binding pocket [chemical binding]; other site 536056010743 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 536056010744 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 536056010745 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 536056010746 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 536056010747 'IS1 transposase InsAB', stop codon appeared' 536056010748 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 536056010749 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 536056010750 hypothetical protein; Provisional; Region: PRK10350 536056010751 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 536056010752 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 536056010753 putative active site [active] 536056010754 catalytic site [active] 536056010755 putative metal binding site [ion binding]; other site 536056010756 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 536056010757 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 536056010758 Walker A/P-loop; other site 536056010759 ATP binding site [chemical binding]; other site 536056010760 Q-loop/lid; other site 536056010761 ABC transporter signature motif; other site 536056010762 Walker B; other site 536056010763 D-loop; other site 536056010764 H-loop/switch region; other site 536056010765 TOBE domain; Region: TOBE_2; pfam08402 536056010766 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 536056010767 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056010768 dimer interface [polypeptide binding]; other site 536056010769 conserved gate region; other site 536056010770 putative PBP binding loops; other site 536056010771 ABC-ATPase subunit interface; other site 536056010772 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 536056010773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056010774 dimer interface [polypeptide binding]; other site 536056010775 conserved gate region; other site 536056010776 putative PBP binding loops; other site 536056010777 ABC-ATPase subunit interface; other site 536056010778 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 536056010779 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 536056010780 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 536056010781 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 536056010782 Walker A/P-loop; other site 536056010783 ATP binding site [chemical binding]; other site 536056010784 Q-loop/lid; other site 536056010785 ABC transporter signature motif; other site 536056010786 Walker B; other site 536056010787 D-loop; other site 536056010788 H-loop/switch region; other site 536056010789 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 536056010790 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 536056010791 Walker A/P-loop; other site 536056010792 ATP binding site [chemical binding]; other site 536056010793 Q-loop/lid; other site 536056010794 ABC transporter signature motif; other site 536056010795 Walker B; other site 536056010796 D-loop; other site 536056010797 H-loop/switch region; other site 536056010798 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 536056010799 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 536056010800 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 536056010801 TM-ABC transporter signature motif; other site 536056010802 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536056010803 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 536056010804 TM-ABC transporter signature motif; other site 536056010805 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 536056010806 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 536056010807 dimerization interface [polypeptide binding]; other site 536056010808 ligand binding site [chemical binding]; other site 536056010809 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 536056010810 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 536056010811 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 536056010812 dimerization interface [polypeptide binding]; other site 536056010813 ligand binding site [chemical binding]; other site 536056010814 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 536056010815 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 536056010816 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 536056010817 DNA binding residues [nucleotide binding] 536056010818 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 536056010819 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 536056010820 cell division protein FtsE; Provisional; Region: PRK10908 536056010821 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536056010822 Walker A/P-loop; other site 536056010823 ATP binding site [chemical binding]; other site 536056010824 Q-loop/lid; other site 536056010825 ABC transporter signature motif; other site 536056010826 Walker B; other site 536056010827 D-loop; other site 536056010828 H-loop/switch region; other site 536056010829 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 536056010830 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 536056010831 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 536056010832 P loop; other site 536056010833 GTP binding site [chemical binding]; other site 536056010834 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 536056010835 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536056010836 S-adenosylmethionine binding site [chemical binding]; other site 536056010837 hypothetical protein; Provisional; Region: PRK10910 536056010838 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 536056010839 Predicted membrane protein [Function unknown]; Region: COG3714 536056010840 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 536056010841 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 536056010842 metal-binding site [ion binding] 536056010843 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 536056010844 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 536056010845 CPxP motif; other site 536056010846 hypothetical protein; Provisional; Region: PRK11212 536056010847 hypothetical protein; Provisional; Region: PRK11615 536056010848 major facilitator superfamily transporter; Provisional; Region: PRK05122 536056010849 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056010850 putative substrate translocation pore; other site 536056010851 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 536056010852 Domain of unknown function DUF20; Region: UPF0118; pfam01594 536056010853 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 536056010854 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 536056010855 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 536056010856 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 536056010857 substrate binding site [chemical binding]; other site 536056010858 nickel transporter permease NikB; Provisional; Region: PRK10352 536056010859 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056010860 dimer interface [polypeptide binding]; other site 536056010861 conserved gate region; other site 536056010862 putative PBP binding loops; other site 536056010863 ABC-ATPase subunit interface; other site 536056010864 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 536056010865 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056010866 dimer interface [polypeptide binding]; other site 536056010867 conserved gate region; other site 536056010868 putative PBP binding loops; other site 536056010869 ABC-ATPase subunit interface; other site 536056010870 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 536056010871 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536056010872 Walker A/P-loop; other site 536056010873 ATP binding site [chemical binding]; other site 536056010874 Q-loop/lid; other site 536056010875 ABC transporter signature motif; other site 536056010876 Walker B; other site 536056010877 D-loop; other site 536056010878 H-loop/switch region; other site 536056010879 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 536056010880 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 536056010881 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536056010882 Walker A/P-loop; other site 536056010883 ATP binding site [chemical binding]; other site 536056010884 Q-loop/lid; other site 536056010885 ABC transporter signature motif; other site 536056010886 Walker B; other site 536056010887 D-loop; other site 536056010888 H-loop/switch region; other site 536056010889 nickel responsive regulator; Provisional; Region: PRK02967 536056010890 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 536056010891 PAAR motif; Region: PAAR_motif; cl15808 536056010892 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 536056010893 RHS Repeat; Region: RHS_repeat; pfam05593 536056010894 RHS Repeat; Region: RHS_repeat; pfam05593 536056010895 RHS Repeat; Region: RHS_repeat; pfam05593 536056010896 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 536056010897 RHS Repeat; Region: RHS_repeat; pfam05593 536056010898 RHS Repeat; Region: RHS_repeat; pfam05593 536056010899 RHS protein; Region: RHS; pfam03527 536056010900 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 536056010901 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 536056010902 predicted protein fragment (pseudogene) 536056010903 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 536056010904 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 536056010905 Transposase [DNA replication, recombination, and repair]; Region: COG5433 536056010906 Transposase [DNA replication, recombination, and repair]; Region: COG5433 536056010907 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 536056010908 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 536056010909 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 536056010910 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 536056010911 Walker A/P-loop; other site 536056010912 ATP binding site [chemical binding]; other site 536056010913 Q-loop/lid; other site 536056010914 ABC transporter signature motif; other site 536056010915 Walker B; other site 536056010916 D-loop; other site 536056010917 H-loop/switch region; other site 536056010918 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 536056010919 Walker A/P-loop; other site 536056010920 ATP binding site [chemical binding]; other site 536056010921 Q-loop/lid; other site 536056010922 ABC transporter signature motif; other site 536056010923 Walker B; other site 536056010924 D-loop; other site 536056010925 H-loop/switch region; other site 536056010926 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 536056010927 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 536056010928 HlyD family secretion protein; Region: HlyD; pfam00529 536056010929 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 536056010930 HlyD family secretion protein; Region: HlyD_3; pfam13437 536056010931 Domain of unknown function (DUF4049); Region: DUF4049; pfam13258 536056010932 Domain of unknown function (DUF4049); Region: DUF4049; pfam13258 536056010933 Domain of unknown function (DUF4049); Region: DUF4049; pfam13258 536056010934 Protein of unknown function (DUF2776); Region: DUF2776; pfam10951 536056010935 Predicted flavoproteins [General function prediction only]; Region: COG2081 536056010936 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 536056010937 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 536056010938 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 536056010939 universal stress protein UspB; Provisional; Region: PRK04960 536056010940 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 536056010941 Ligand Binding Site [chemical binding]; other site 536056010942 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 536056010943 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056010944 POT family; Region: PTR2; pfam00854 536056010945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536056010946 S-adenosylmethionine binding site [chemical binding]; other site 536056010947 oligopeptidase A; Provisional; Region: PRK10911 536056010948 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 536056010949 active site 536056010950 Zn binding site [ion binding]; other site 536056010951 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 536056010952 glutathione reductase; Validated; Region: PRK06116 536056010953 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 536056010954 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 536056010955 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 536056010956 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536056010957 dimerization interface [polypeptide binding]; other site 536056010958 putative DNA binding site [nucleotide binding]; other site 536056010959 putative Zn2+ binding site [ion binding]; other site 536056010960 arsenical pump membrane protein; Provisional; Region: PRK15445 536056010961 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 536056010962 transmembrane helices; other site 536056010963 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 536056010964 ArsC family; Region: ArsC; pfam03960 536056010965 catalytic residues [active] 536056010966 Transposase domain (DUF772); Region: DUF772; pfam05598 536056010967 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 536056010968 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 536056010969 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 536056010970 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 536056010971 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536056010972 DNA binding residues [nucleotide binding] 536056010973 dimerization interface [polypeptide binding]; other site 536056010974 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 536056010975 MgtC family; Region: MgtC; pfam02308 536056010976 acid-resistance protein; Provisional; Region: hdeB; PRK11566 536056010977 acid-resistance protein; Provisional; Region: PRK10208 536056010978 acid-resistance membrane protein; Provisional; Region: PRK10209 536056010979 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 536056010980 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 536056010981 pyruvate kinase; Provisional; Region: PRK05826 536056010982 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 536056010983 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 536056010984 HlyD family secretion protein; Region: HlyD_3; pfam13437 536056010985 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 536056010986 Protein export membrane protein; Region: SecD_SecF; cl14618 536056010987 transcriptional regulator YdeO; Provisional; Region: PRK09940 536056010988 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536056010989 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 536056010990 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536056010991 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 536056010992 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056010993 catalytic residue [active] 536056010994 Haem-binding domain; Region: Haem_bd; pfam14376 536056010995 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 536056010996 trehalase; Provisional; Region: treF; PRK13270 536056010997 Trehalase; Region: Trehalase; pfam01204 536056010998 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 536056010999 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536056011000 DNA binding residues [nucleotide binding] 536056011001 dimerization interface [polypeptide binding]; other site 536056011002 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536056011003 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056011004 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 536056011005 putative effector binding pocket; other site 536056011006 putative dimerization interface [polypeptide binding]; other site 536056011007 inner membrane protein YhjD; Region: TIGR00766 536056011008 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056011009 metabolite-proton symporter; Region: 2A0106; TIGR00883 536056011010 putative substrate translocation pore; other site 536056011011 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 536056011012 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 536056011013 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 536056011014 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 536056011015 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 536056011016 substrate binding site [chemical binding]; other site 536056011017 ATP binding site [chemical binding]; other site 536056011018 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 536056011019 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 536056011020 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 536056011021 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 536056011022 putative diguanylate cyclase; Provisional; Region: PRK13561 536056011023 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 536056011024 metal binding site [ion binding]; metal-binding site 536056011025 active site 536056011026 I-site; other site 536056011027 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 536056011028 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 536056011029 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536056011030 binding surface 536056011031 TPR motif; other site 536056011032 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536056011033 binding surface 536056011034 TPR motif; other site 536056011035 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 536056011036 endo-1,4-D-glucanase; Provisional; Region: PRK11097 536056011037 cellulose synthase regulator protein; Provisional; Region: PRK11114 536056011038 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 536056011039 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 536056011040 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 536056011041 DXD motif; other site 536056011042 PilZ domain; Region: PilZ; pfam07238 536056011043 cell division protein; Provisional; Region: PRK10037 536056011044 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 536056011045 P-loop; other site 536056011046 Magnesium ion binding site [ion binding]; other site 536056011047 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 536056011048 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 536056011049 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 536056011050 celllulose biosynthesis operon protein BcsF/YhjT; Region: cellullose_BcsF; TIGR03493 536056011051 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 536056011052 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 536056011053 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 536056011054 serine transporter; Region: stp; TIGR00814 536056011055 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 536056011056 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536056011057 Walker A/P-loop; other site 536056011058 ATP binding site [chemical binding]; other site 536056011059 Q-loop/lid; other site 536056011060 ABC transporter signature motif; other site 536056011061 Walker B; other site 536056011062 D-loop; other site 536056011063 H-loop/switch region; other site 536056011064 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 536056011065 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 536056011066 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536056011067 Walker A/P-loop; other site 536056011068 ATP binding site [chemical binding]; other site 536056011069 Q-loop/lid; other site 536056011070 ABC transporter signature motif; other site 536056011071 Walker B; other site 536056011072 D-loop; other site 536056011073 H-loop/switch region; other site 536056011074 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 536056011075 dipeptide transporter; Provisional; Region: PRK10913 536056011076 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 536056011077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056011078 dimer interface [polypeptide binding]; other site 536056011079 conserved gate region; other site 536056011080 putative PBP binding loops; other site 536056011081 ABC-ATPase subunit interface; other site 536056011082 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 536056011083 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056011084 dimer interface [polypeptide binding]; other site 536056011085 conserved gate region; other site 536056011086 putative PBP binding loops; other site 536056011087 ABC-ATPase subunit interface; other site 536056011088 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 536056011089 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 536056011090 peptide binding site [polypeptide binding]; other site 536056011091 phosphoethanolamine transferase; Provisional; Region: PRK11560 536056011092 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 536056011093 Sulfatase; Region: Sulfatase; pfam00884 536056011094 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 536056011095 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056011096 putative substrate translocation pore; other site 536056011097 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 536056011098 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 536056011099 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 536056011100 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536056011101 Coenzyme A binding pocket [chemical binding]; other site 536056011102 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 536056011103 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 536056011104 molybdopterin cofactor binding site [chemical binding]; other site 536056011105 substrate binding site [chemical binding]; other site 536056011106 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 536056011107 molybdopterin cofactor binding site; other site 536056011108 putative outer membrane lipoprotein; Provisional; Region: PRK10510 536056011109 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 536056011110 ligand binding site [chemical binding]; other site 536056011111 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 536056011112 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 536056011113 dimerization interface [polypeptide binding]; other site 536056011114 ligand binding site [chemical binding]; other site 536056011115 NADP binding site [chemical binding]; other site 536056011116 catalytic site [active] 536056011117 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 536056011118 Predicted transcriptional regulator [Transcription]; Region: COG2944 536056011119 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536056011120 non-specific DNA binding site [nucleotide binding]; other site 536056011121 salt bridge; other site 536056011122 sequence-specific DNA binding site [nucleotide binding]; other site 536056011123 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 536056011124 DNA-binding site [nucleotide binding]; DNA binding site 536056011125 RNA-binding motif; other site 536056011126 small toxic polypeptide; Provisional; Region: PRK09759 536056011127 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 536056011128 Helix-turn-helix domain; Region: HTH_28; pfam13518 536056011129 Helix-turn-helix domain; Region: HTH_28; pfam13518 536056011130 putative transposase OrfB; Reviewed; Region: PHA02517 536056011131 HTH-like domain; Region: HTH_21; pfam13276 536056011132 Integrase core domain; Region: rve; pfam00665 536056011133 Integrase core domain; Region: rve_2; pfam13333 536056011134 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 536056011135 DALR anticodon binding domain; Region: DALR_1; pfam05746 536056011136 anticodon binding site; other site 536056011137 tRNA binding surface [nucleotide binding]; other site 536056011138 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 536056011139 dimer interface [polypeptide binding]; other site 536056011140 motif 1; other site 536056011141 active site 536056011142 motif 2; other site 536056011143 motif 3; other site 536056011144 YsaB-like lipoprotein; Region: YsaB; pfam13983 536056011145 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 536056011146 Acyltransferase family; Region: Acyl_transf_3; pfam01757 536056011147 hypothetical protein; Provisional; Region: PRK11383 536056011148 yiaA/B two helix domain; Region: YiaAB; pfam05360 536056011149 yiaA/B two helix domain; Region: YiaAB; pfam05360 536056011150 hypothetical protein; Provisional; Region: PRK11403 536056011151 yiaA/B two helix domain; Region: YiaAB; pfam05360 536056011152 xylulokinase; Provisional; Region: PRK15027 536056011153 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 536056011154 N- and C-terminal domain interface [polypeptide binding]; other site 536056011155 active site 536056011156 MgATP binding site [chemical binding]; other site 536056011157 catalytic site [active] 536056011158 metal binding site [ion binding]; metal-binding site 536056011159 xylulose binding site [chemical binding]; other site 536056011160 homodimer interface [polypeptide binding]; other site 536056011161 xylose isomerase; Provisional; Region: PRK05474 536056011162 xylose isomerase; Region: xylose_isom_A; TIGR02630 536056011163 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 536056011164 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 536056011165 putative ligand binding site [chemical binding]; other site 536056011166 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 536056011167 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536056011168 Walker A/P-loop; other site 536056011169 ATP binding site [chemical binding]; other site 536056011170 Q-loop/lid; other site 536056011171 ABC transporter signature motif; other site 536056011172 Walker B; other site 536056011173 D-loop; other site 536056011174 H-loop/switch region; other site 536056011175 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 536056011176 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536056011177 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536056011178 TM-ABC transporter signature motif; other site 536056011179 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 536056011180 putative dimerization interface [polypeptide binding]; other site 536056011181 Transcriptional regulators [Transcription]; Region: PurR; COG1609 536056011182 putative ligand binding site [chemical binding]; other site 536056011183 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536056011184 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 536056011185 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536056011186 hypothetical protein; Provisional; Region: PRK10356 536056011187 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 536056011188 alpha-amylase; Reviewed; Region: malS; PRK09505 536056011189 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 536056011190 active site 536056011191 catalytic site [active] 536056011192 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 536056011193 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 536056011194 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056011195 homodimer interface [polypeptide binding]; other site 536056011196 catalytic residue [active] 536056011197 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 536056011198 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 536056011199 Transcriptional regulator [Transcription]; Region: IclR; COG1414 536056011200 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 536056011201 Bacterial transcriptional regulator; Region: IclR; pfam01614 536056011202 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 536056011203 uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022 536056011204 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 536056011205 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 536056011206 DctM-like transporters; Region: DctM; pfam06808 536056011207 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 536056011208 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 536056011209 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 536056011210 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 536056011211 putative N- and C-terminal domain interface [polypeptide binding]; other site 536056011212 putative active site [active] 536056011213 MgATP binding site [chemical binding]; other site 536056011214 catalytic site [active] 536056011215 metal binding site [ion binding]; metal-binding site 536056011216 putative xylulose binding site [chemical binding]; other site 536056011217 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 536056011218 active site 536056011219 dimer interface [polypeptide binding]; other site 536056011220 magnesium binding site [ion binding]; other site 536056011221 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 536056011222 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 536056011223 AP (apurinic/apyrimidinic) site pocket; other site 536056011224 DNA interaction; other site 536056011225 Metal-binding active site; metal-binding site 536056011226 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 536056011227 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 536056011228 intersubunit interface [polypeptide binding]; other site 536056011229 active site 536056011230 Zn2+ binding site [ion binding]; other site 536056011231 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 536056011232 Transcriptional regulator [Transcription]; Region: LysR; COG0583 536056011233 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056011234 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 536056011235 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 536056011236 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 536056011237 HlyD family secretion protein; Region: HlyD_3; pfam13437 536056011238 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 536056011239 FlxA-like protein; Region: FlxA; pfam14282 536056011240 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 536056011241 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 536056011242 NAD(P) binding site [chemical binding]; other site 536056011243 catalytic residues [active] 536056011244 putative alcohol dehydrogenase; Provisional; Region: PRK09860 536056011245 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 536056011246 dimer interface [polypeptide binding]; other site 536056011247 active site 536056011248 metal binding site [ion binding]; metal-binding site 536056011249 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 536056011250 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 536056011251 G1 box; other site 536056011252 putative GEF interaction site [polypeptide binding]; other site 536056011253 GTP/Mg2+ binding site [chemical binding]; other site 536056011254 Switch I region; other site 536056011255 G2 box; other site 536056011256 G3 box; other site 536056011257 Switch II region; other site 536056011258 G4 box; other site 536056011259 G5 box; other site 536056011260 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 536056011261 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 536056011262 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 536056011263 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 536056011264 selenocysteine synthase; Provisional; Region: PRK04311 536056011265 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 536056011266 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 536056011267 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 536056011268 catalytic residue [active] 536056011269 putative glutathione S-transferase; Provisional; Region: PRK10357 536056011270 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 536056011271 putative C-terminal domain interface [polypeptide binding]; other site 536056011272 putative GSH binding site (G-site) [chemical binding]; other site 536056011273 putative dimer interface [polypeptide binding]; other site 536056011274 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 536056011275 dimer interface [polypeptide binding]; other site 536056011276 N-terminal domain interface [polypeptide binding]; other site 536056011277 putative substrate binding pocket (H-site) [chemical binding]; other site 536056011278 PAAR motif; Region: PAAR_motif; cl15808 536056011279 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 536056011280 RHS Repeat; Region: RHS_repeat; pfam05593 536056011281 RHS Repeat; Region: RHS_repeat; pfam05593 536056011282 RHS Repeat; Region: RHS_repeat; pfam05593 536056011283 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 536056011284 RHS Repeat; Region: RHS_repeat; pfam05593 536056011285 RHS Repeat; Region: RHS_repeat; pfam05593 536056011286 RHS protein; Region: RHS; pfam03527 536056011287 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 536056011288 putative lyase; Provisional; Region: PRK09687 536056011289 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 536056011290 RHS protein; Region: RHS; pfam03527 536056011291 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 536056011292 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 536056011293 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 536056011294 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 536056011295 HlyD family secretion protein; Region: HlyD_3; pfam13437 536056011296 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 536056011297 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 536056011298 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 536056011299 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 536056011300 active site 536056011301 P-loop; other site 536056011302 phosphorylation site [posttranslational modification] 536056011303 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 536056011304 active site 536056011305 phosphorylation site [posttranslational modification] 536056011306 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 536056011307 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 536056011308 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 536056011309 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 536056011310 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 536056011311 hypothetical protein; Provisional; Region: PRK11020 536056011312 L-lactate permease; Provisional; Region: PRK10420 536056011313 glycolate transporter; Provisional; Region: PRK09695 536056011314 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 536056011315 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536056011316 DNA-binding site [nucleotide binding]; DNA binding site 536056011317 FCD domain; Region: FCD; pfam07729 536056011318 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 536056011319 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 536056011320 phosphate binding site [ion binding]; other site 536056011321 putative rRNA methylase; Provisional; Region: PRK10358 536056011322 serine acetyltransferase; Provisional; Region: cysE; PRK11132 536056011323 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 536056011324 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 536056011325 trimer interface [polypeptide binding]; other site 536056011326 active site 536056011327 substrate binding site [chemical binding]; other site 536056011328 CoA binding site [chemical binding]; other site 536056011329 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 536056011330 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 536056011331 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 536056011332 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 536056011333 SecA binding site; other site 536056011334 Preprotein binding site; other site 536056011335 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 536056011336 GSH binding site [chemical binding]; other site 536056011337 catalytic residues [active] 536056011338 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 536056011339 active site residue [active] 536056011340 phosphoglyceromutase; Provisional; Region: PRK05434 536056011341 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 536056011342 AmiB activator; Provisional; Region: PRK11637 536056011343 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 536056011344 Peptidase family M23; Region: Peptidase_M23; pfam01551 536056011345 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 536056011346 NodB motif; other site 536056011347 putative active site [active] 536056011348 putative catalytic site [active] 536056011349 Zn binding site [ion binding]; other site 536056011350 putative glycosyl transferase; Provisional; Region: PRK10073 536056011351 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 536056011352 active site 536056011353 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 536056011354 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 536056011355 NAD(P) binding site [chemical binding]; other site 536056011356 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 536056011357 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 536056011358 substrate-cofactor binding pocket; other site 536056011359 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056011360 catalytic residue [active] 536056011361 hypothetical protein; Provisional; Region: PRK11346 536056011362 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 536056011363 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 536056011364 NADP binding site [chemical binding]; other site 536056011365 homopentamer interface [polypeptide binding]; other site 536056011366 substrate binding site [chemical binding]; other site 536056011367 active site 536056011368 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 536056011369 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 536056011370 putative active site [active] 536056011371 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 536056011372 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 536056011373 putative active site [active] 536056011374 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 536056011375 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 536056011376 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 536056011377 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 536056011378 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 536056011379 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10359 536056011380 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 536056011381 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 536056011382 Ligand binding site; other site 536056011383 metal-binding site 536056011384 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 536056011385 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 536056011386 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 536056011387 Ligand binding site; other site 536056011388 metal-binding site 536056011389 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 536056011390 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922 536056011391 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 536056011392 putative ADP-binding pocket [chemical binding]; other site 536056011393 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 536056011394 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 536056011395 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 536056011396 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 536056011397 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 536056011398 putative active site [active] 536056011399 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 536056011400 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 536056011401 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 536056011402 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 536056011403 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 536056011404 active site 536056011405 (T/H)XGH motif; other site 536056011406 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 536056011407 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 536056011408 DNA binding site [nucleotide binding] 536056011409 catalytic residue [active] 536056011410 H2TH interface [polypeptide binding]; other site 536056011411 putative catalytic residues [active] 536056011412 turnover-facilitating residue; other site 536056011413 intercalation triad [nucleotide binding]; other site 536056011414 8OG recognition residue [nucleotide binding]; other site 536056011415 putative reading head residues; other site 536056011416 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 536056011417 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 536056011418 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 536056011419 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 536056011420 hypothetical protein; Reviewed; Region: PRK00024 536056011421 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 536056011422 MPN+ (JAMM) motif; other site 536056011423 Zinc-binding site [ion binding]; other site 536056011424 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 536056011425 Flavoprotein; Region: Flavoprotein; pfam02441 536056011426 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 536056011427 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 536056011428 trimer interface [polypeptide binding]; other site 536056011429 active site 536056011430 division inhibitor protein; Provisional; Region: slmA; PRK09480 536056011431 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536056011432 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 536056011433 active site 536056011434 ribonuclease PH; Reviewed; Region: rph; PRK00173 536056011435 Ribonuclease PH; Region: RNase_PH_bact; cd11362 536056011436 hexamer interface [polypeptide binding]; other site 536056011437 active site 536056011438 hypothetical protein; Provisional; Region: PRK11820 536056011439 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 536056011440 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 536056011441 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 536056011442 BRO family, N-terminal domain; Region: Bro-N; pfam02498 536056011443 Predicted membrane protein [Function unknown]; Region: COG2860 536056011444 UPF0126 domain; Region: UPF0126; pfam03458 536056011445 UPF0126 domain; Region: UPF0126; pfam03458 536056011446 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 536056011447 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 536056011448 nucleotide binding pocket [chemical binding]; other site 536056011449 K-X-D-G motif; other site 536056011450 catalytic site [active] 536056011451 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 536056011452 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 536056011453 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 536056011454 catalytic site [active] 536056011455 G-X2-G-X-G-K; other site 536056011456 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 536056011457 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 536056011458 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 536056011459 Zn2+ binding site [ion binding]; other site 536056011460 Mg2+ binding site [ion binding]; other site 536056011461 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 536056011462 synthetase active site [active] 536056011463 NTP binding site [chemical binding]; other site 536056011464 metal binding site [ion binding]; metal-binding site 536056011465 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 536056011466 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 536056011467 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 536056011468 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 536056011469 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 536056011470 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 536056011471 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 536056011472 generic binding surface II; other site 536056011473 ssDNA binding site; other site 536056011474 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 536056011475 ATP binding site [chemical binding]; other site 536056011476 putative Mg++ binding site [ion binding]; other site 536056011477 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 536056011478 nucleotide binding region [chemical binding]; other site 536056011479 ATP-binding site [chemical binding]; other site 536056011480 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 536056011481 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 536056011482 AsmA family; Region: AsmA; pfam05170 536056011483 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 536056011484 putative alpha-glucosidase; Provisional; Region: PRK10658 536056011485 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 536056011486 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 536056011487 active site 536056011488 homotrimer interface [polypeptide binding]; other site 536056011489 catalytic site [active] 536056011490 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 536056011491 putative transporter; Provisional; Region: PRK11462 536056011492 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 536056011493 sugar efflux transporter; Region: 2A0120; TIGR00899 536056011494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056011495 putative substrate translocation pore; other site 536056011496 EamA-like transporter family; Region: EamA; pfam00892 536056011497 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 536056011498 EamA-like transporter family; Region: EamA; pfam00892 536056011499 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 536056011500 lipoprotein, YaeC family; Region: TIGR00363 536056011501 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 536056011502 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 536056011503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056011504 putative substrate translocation pore; other site 536056011505 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 536056011506 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 536056011507 cryptic adenine deaminase; Provisional; Region: PRK10027 536056011508 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 536056011509 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 536056011510 active site 536056011511 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 536056011512 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 536056011513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056011514 putative substrate translocation pore; other site 536056011515 regulatory protein UhpC; Provisional; Region: PRK11663 536056011516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056011517 putative substrate translocation pore; other site 536056011518 sensory histidine kinase UhpB; Provisional; Region: PRK11644 536056011519 MASE1; Region: MASE1; pfam05231 536056011520 Histidine kinase; Region: HisKA_3; pfam07730 536056011521 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 536056011522 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536056011523 active site 536056011524 phosphorylation site [posttranslational modification] 536056011525 intermolecular recognition site; other site 536056011526 dimerization interface [polypeptide binding]; other site 536056011527 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536056011528 DNA binding residues [nucleotide binding] 536056011529 dimerization interface [polypeptide binding]; other site 536056011530 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 536056011531 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 536056011532 putative valine binding site [chemical binding]; other site 536056011533 dimer interface [polypeptide binding]; other site 536056011534 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 536056011535 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 536056011536 PYR/PP interface [polypeptide binding]; other site 536056011537 dimer interface [polypeptide binding]; other site 536056011538 TPP binding site [chemical binding]; other site 536056011539 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 536056011540 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 536056011541 TPP-binding site [chemical binding]; other site 536056011542 dimer interface [polypeptide binding]; other site 536056011543 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 536056011544 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056011545 putative substrate translocation pore; other site 536056011546 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 536056011547 Domain of unknown function (DUF202); Region: DUF202; pfam02656 536056011548 Predicted membrane protein [Function unknown]; Region: COG2149 536056011549 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 536056011550 Sulfatase; Region: Sulfatase; pfam00884 536056011551 putative transporter; Provisional; Region: PRK10484 536056011552 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 536056011553 Na binding site [ion binding]; other site 536056011554 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 536056011555 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536056011556 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 536056011557 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 536056011558 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 536056011559 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 536056011560 NAD(P) binding site [chemical binding]; other site 536056011561 LDH/MDH dimer interface [polypeptide binding]; other site 536056011562 substrate binding site [chemical binding]; other site 536056011563 PTS system arbutin-specific transporter subunit IIB; Provisional; Region: PRK09702 536056011564 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 536056011565 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 536056011566 active site turn [active] 536056011567 phosphorylation site [posttranslational modification] 536056011568 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 536056011569 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 536056011570 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 536056011571 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536056011572 DNA-binding site [nucleotide binding]; DNA binding site 536056011573 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 536056011574 putative transporter; Validated; Region: PRK03818 536056011575 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 536056011576 TrkA-C domain; Region: TrkA_C; pfam02080 536056011577 TrkA-C domain; Region: TrkA_C; pfam02080 536056011578 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 536056011579 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 536056011580 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 536056011581 putative dimer interface [polypeptide binding]; other site 536056011582 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 536056011583 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 536056011584 putative dimer interface [polypeptide binding]; other site 536056011585 hypothetical protein; Provisional; Region: PRK11616 536056011586 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 536056011587 putative oxidoreductase; Provisional; Region: PRK11445 536056011588 hypothetical protein; Provisional; Region: PRK07236 536056011589 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056011590 D-galactonate transporter; Region: 2A0114; TIGR00893 536056011591 putative substrate translocation pore; other site 536056011592 galactonate dehydratase; Provisional; Region: PRK14017 536056011593 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 536056011594 putative active site pocket [active] 536056011595 putative metal binding site [ion binding]; other site 536056011596 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 536056011597 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 536056011598 active site 536056011599 intersubunit interface [polypeptide binding]; other site 536056011600 catalytic residue [active] 536056011601 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 536056011602 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 536056011603 Transcriptional regulators [Transcription]; Region: FadR; COG2186 536056011604 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536056011605 DNA-binding site [nucleotide binding]; DNA binding site 536056011606 FCD domain; Region: FCD; pfam07729 536056011607 hypothetical protein; Provisional; Region: PRK10215 536056011608 sugar phosphate phosphatase; Provisional; Region: PRK10513 536056011609 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536056011610 active site 536056011611 motif I; other site 536056011612 motif II; other site 536056011613 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536056011614 hypothetical protein; Provisional; Region: PRK11426 536056011615 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 536056011616 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536056011617 Mg2+ binding site [ion binding]; other site 536056011618 G-X-G motif; other site 536056011619 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 536056011620 anchoring element; other site 536056011621 dimer interface [polypeptide binding]; other site 536056011622 ATP binding site [chemical binding]; other site 536056011623 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 536056011624 active site 536056011625 putative metal-binding site [ion binding]; other site 536056011626 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 536056011627 recF protein; Region: recf; TIGR00611 536056011628 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536056011629 Walker A/P-loop; other site 536056011630 ATP binding site [chemical binding]; other site 536056011631 Q-loop/lid; other site 536056011632 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536056011633 ABC transporter signature motif; other site 536056011634 Walker B; other site 536056011635 D-loop; other site 536056011636 H-loop/switch region; other site 536056011637 DNA polymerase III subunit beta; Validated; Region: PRK05643 536056011638 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 536056011639 putative DNA binding surface [nucleotide binding]; other site 536056011640 dimer interface [polypeptide binding]; other site 536056011641 beta-clamp/clamp loader binding surface; other site 536056011642 beta-clamp/translesion DNA polymerase binding surface; other site 536056011643 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 536056011644 DnaA N-terminal domain; Region: DnaA_N; pfam11638 536056011645 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536056011646 Walker A motif; other site 536056011647 ATP binding site [chemical binding]; other site 536056011648 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 536056011649 Walker B motif; other site 536056011650 arginine finger; other site 536056011651 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 536056011652 DnaA box-binding interface [nucleotide binding]; other site 536056011653 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 536056011654 ribonuclease P; Reviewed; Region: rnpA; PRK01732 536056011655 hypothetical protein; Validated; Region: PRK00041 536056011656 membrane protein insertase; Provisional; Region: PRK01318 536056011657 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 536056011658 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 536056011659 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 536056011660 trmE is a tRNA modification GTPase; Region: trmE; cd04164 536056011661 G1 box; other site 536056011662 GTP/Mg2+ binding site [chemical binding]; other site 536056011663 Switch I region; other site 536056011664 G2 box; other site 536056011665 Switch II region; other site 536056011666 G3 box; other site 536056011667 G4 box; other site 536056011668 G5 box; other site 536056011669 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 536056011670 Tryptophanese operon leader peptide; Region: Tna_leader; pfam08053 536056011671 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 536056011672 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 536056011673 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 536056011674 catalytic residue [active] 536056011675 'tryptophan transporter of low affinity, pseudogene fragment due to insertion' 536056011676 Transposase domain (DUF772); Region: DUF772; pfam05598 536056011677 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 536056011678 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 536056011679 tryptophan transporter of low affinity 536056011680 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 536056011681 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056011682 putative substrate translocation pore; other site 536056011683 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 536056011684 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056011685 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 536056011686 substrate binding pocket [chemical binding]; other site 536056011687 dimerization interface [polypeptide binding]; other site 536056011688 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 536056011689 Predicted flavoprotein [General function prediction only]; Region: COG0431 536056011690 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 536056011691 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 536056011692 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 536056011693 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536056011694 active site 536056011695 motif I; other site 536056011696 motif II; other site 536056011697 putative inner membrane protein; Provisional; Region: PRK09823 536056011698 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3196 536056011699 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 536056011700 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 536056011701 active site 536056011702 trimer interface [polypeptide binding]; other site 536056011703 allosteric site; other site 536056011704 active site lid [active] 536056011705 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 536056011706 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 536056011707 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 536056011708 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 536056011709 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 536056011710 trimer interface; other site 536056011711 sugar binding site [chemical binding]; other site 536056011712 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 536056011713 beta-galactosidase; Region: BGL; TIGR03356 536056011714 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 536056011715 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 536056011716 active site turn [active] 536056011717 phosphorylation site [posttranslational modification] 536056011718 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 536056011719 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 536056011720 HPr interaction site; other site 536056011721 glycerol kinase (GK) interaction site [polypeptide binding]; other site 536056011722 active site 536056011723 phosphorylation site [posttranslational modification] 536056011724 transcriptional antiterminator BglG; Provisional; Region: PRK09772 536056011725 CAT RNA binding domain; Region: CAT_RBD; pfam03123 536056011726 PRD domain; Region: PRD; pfam00874 536056011727 PRD domain; Region: PRD; pfam00874 536056011728 transcriptional regulator PhoU; Provisional; Region: PRK11115 536056011729 PhoU domain; Region: PhoU; pfam01895 536056011730 PhoU domain; Region: PhoU; pfam01895 536056011731 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 536056011732 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 536056011733 Walker A/P-loop; other site 536056011734 ATP binding site [chemical binding]; other site 536056011735 Q-loop/lid; other site 536056011736 ABC transporter signature motif; other site 536056011737 Walker B; other site 536056011738 D-loop; other site 536056011739 H-loop/switch region; other site 536056011740 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 536056011741 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056011742 dimer interface [polypeptide binding]; other site 536056011743 conserved gate region; other site 536056011744 putative PBP binding loops; other site 536056011745 ABC-ATPase subunit interface; other site 536056011746 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 536056011747 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056011748 dimer interface [polypeptide binding]; other site 536056011749 conserved gate region; other site 536056011750 putative PBP binding loops; other site 536056011751 ABC-ATPase subunit interface; other site 536056011752 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536056011753 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 536056011754 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 536056011755 glutaminase active site [active] 536056011756 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 536056011757 dimer interface [polypeptide binding]; other site 536056011758 active site 536056011759 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 536056011760 dimer interface [polypeptide binding]; other site 536056011761 active site 536056011762 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 536056011763 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 536056011764 Substrate binding site; other site 536056011765 Mg++ binding site; other site 536056011766 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 536056011767 active site 536056011768 substrate binding site [chemical binding]; other site 536056011769 CoA binding site [chemical binding]; other site 536056011770 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 536056011771 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 536056011772 gamma subunit interface [polypeptide binding]; other site 536056011773 epsilon subunit interface [polypeptide binding]; other site 536056011774 LBP interface [polypeptide binding]; other site 536056011775 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 536056011776 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 536056011777 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 536056011778 alpha subunit interaction interface [polypeptide binding]; other site 536056011779 Walker A motif; other site 536056011780 ATP binding site [chemical binding]; other site 536056011781 Walker B motif; other site 536056011782 inhibitor binding site; inhibition site 536056011783 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 536056011784 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 536056011785 core domain interface [polypeptide binding]; other site 536056011786 delta subunit interface [polypeptide binding]; other site 536056011787 epsilon subunit interface [polypeptide binding]; other site 536056011788 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 536056011789 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 536056011790 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 536056011791 beta subunit interaction interface [polypeptide binding]; other site 536056011792 Walker A motif; other site 536056011793 ATP binding site [chemical binding]; other site 536056011794 Walker B motif; other site 536056011795 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 536056011796 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 536056011797 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 536056011798 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 536056011799 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 536056011800 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 536056011801 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 536056011802 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 536056011803 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 536056011804 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 536056011805 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536056011806 S-adenosylmethionine binding site [chemical binding]; other site 536056011807 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 536056011808 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 536056011809 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 536056011810 FMN-binding protein MioC; Provisional; Region: PRK09004 536056011811 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 536056011812 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536056011813 putative DNA binding site [nucleotide binding]; other site 536056011814 putative Zn2+ binding site [ion binding]; other site 536056011815 AsnC family; Region: AsnC_trans_reg; pfam01037 536056011816 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 536056011817 dimer interface [polypeptide binding]; other site 536056011818 active site 536056011819 hypothetical protein; Provisional; Region: yieM; PRK10997 536056011820 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 536056011821 metal ion-dependent adhesion site (MIDAS); other site 536056011822 regulatory ATPase RavA; Provisional; Region: PRK13531 536056011823 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536056011824 Walker A motif; other site 536056011825 ATP binding site [chemical binding]; other site 536056011826 Walker B motif; other site 536056011827 arginine finger; other site 536056011828 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 536056011829 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 536056011830 potassium uptake protein; Region: kup; TIGR00794 536056011831 D-ribose pyranase; Provisional; Region: PRK11797 536056011832 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 536056011833 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536056011834 Walker A/P-loop; other site 536056011835 ATP binding site [chemical binding]; other site 536056011836 Q-loop/lid; other site 536056011837 ABC transporter signature motif; other site 536056011838 Walker B; other site 536056011839 D-loop; other site 536056011840 H-loop/switch region; other site 536056011841 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 536056011842 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536056011843 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536056011844 TM-ABC transporter signature motif; other site 536056011845 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 536056011846 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 536056011847 ligand binding site [chemical binding]; other site 536056011848 dimerization interface [polypeptide binding]; other site 536056011849 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 536056011850 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 536056011851 substrate binding site [chemical binding]; other site 536056011852 dimer interface [polypeptide binding]; other site 536056011853 ATP binding site [chemical binding]; other site 536056011854 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 536056011855 DNA binding site [nucleotide binding] 536056011856 domain linker motif; other site 536056011857 putative transporter; Provisional; Region: PRK10504 536056011858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056011859 putative substrate translocation pore; other site 536056011860 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056011861 Transcriptional regulators [Transcription]; Region: FadR; COG2186 536056011862 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536056011863 DNA-binding site [nucleotide binding]; DNA binding site 536056011864 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 536056011865 transcriptional regulator HdfR; Provisional; Region: PRK03601 536056011866 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056011867 LysR substrate binding domain; Region: LysR_substrate; pfam03466 536056011868 dimerization interface [polypeptide binding]; other site 536056011869 hypothetical protein; Provisional; Region: PRK11027 536056011870 putative ATP-dependent protease; Provisional; Region: PRK09862 536056011871 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 536056011872 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536056011873 Walker A motif; other site 536056011874 ATP binding site [chemical binding]; other site 536056011875 Walker B motif; other site 536056011876 arginine finger; other site 536056011877 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 536056011878 ilvG operon leader peptide; Provisional; Region: PRK10424 536056011879 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 536056011880 PYR/PP interface [polypeptide binding]; other site 536056011881 dimer interface [polypeptide binding]; other site 536056011882 TPP binding site [chemical binding]; other site 536056011883 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 536056011884 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 536056011885 TPP-binding site [chemical binding]; other site 536056011886 dimer interface [polypeptide binding]; other site 536056011887 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 536056011888 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 536056011889 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 536056011890 homodimer interface [polypeptide binding]; other site 536056011891 substrate-cofactor binding pocket; other site 536056011892 catalytic residue [active] 536056011893 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 536056011894 threonine dehydratase; Reviewed; Region: PRK09224 536056011895 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 536056011896 tetramer interface [polypeptide binding]; other site 536056011897 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056011898 catalytic residue [active] 536056011899 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 536056011900 putative Ile/Val binding site [chemical binding]; other site 536056011901 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 536056011902 putative Ile/Val binding site [chemical binding]; other site 536056011903 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056011904 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 536056011905 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 536056011906 putative dimerization interface [polypeptide binding]; other site 536056011907 ketol-acid reductoisomerase; Validated; Region: PRK05225 536056011908 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 536056011909 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 536056011910 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 536056011911 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 536056011912 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 536056011913 PemK-like protein; Region: PemK; cl00995 536056011914 PemK-like protein; Region: PemK; cl00995 536056011915 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 536056011916 Part of AAA domain; Region: AAA_19; pfam13245 536056011917 Family description; Region: UvrD_C_2; pfam13538 536056011918 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 536056011919 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 536056011920 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 536056011921 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 536056011922 ATP binding site [chemical binding]; other site 536056011923 Mg++ binding site [ion binding]; other site 536056011924 motif III; other site 536056011925 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 536056011926 nucleotide binding region [chemical binding]; other site 536056011927 ATP-binding site [chemical binding]; other site 536056011928 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 536056011929 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 536056011930 catalytic residues [active] 536056011931 putative rho operon leader peptide; Provisional; Region: PRK09979 536056011932 transcription termination factor Rho; Provisional; Region: rho; PRK09376 536056011933 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 536056011934 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 536056011935 RNA binding site [nucleotide binding]; other site 536056011936 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 536056011937 multimer interface [polypeptide binding]; other site 536056011938 Walker A motif; other site 536056011939 ATP binding site [chemical binding]; other site 536056011940 Walker B motif; other site 536056011941 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 536056011942 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 536056011943 Mg++ binding site [ion binding]; other site 536056011944 putative catalytic motif [active] 536056011945 substrate binding site [chemical binding]; other site 536056011946 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 536056011947 Chain length determinant protein; Region: Wzz; pfam02706 536056011948 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 536056011949 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 536056011950 active site 536056011951 homodimer interface [polypeptide binding]; other site 536056011952 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 536056011953 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 536056011954 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 536056011955 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 536056011956 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 536056011957 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 536056011958 NAD binding site [chemical binding]; other site 536056011959 substrate binding site [chemical binding]; other site 536056011960 homodimer interface [polypeptide binding]; other site 536056011961 active site 536056011962 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 536056011963 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 536056011964 substrate binding site; other site 536056011965 tetramer interface; other site 536056011966 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 536056011967 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 536056011968 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 536056011969 inhibitor-cofactor binding pocket; inhibition site 536056011970 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056011971 catalytic residue [active] 536056011972 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 536056011973 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 536056011974 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 536056011975 putative common antigen polymerase; Provisional; Region: PRK02975 536056011976 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 536056011977 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 536056011978 putative transport protein YifK; Provisional; Region: PRK10746 536056011979 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 536056011980 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 536056011981 FeS/SAM binding site; other site 536056011982 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 536056011983 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 536056011984 Sulfatase; Region: Sulfatase; pfam00884 536056011985 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 536056011986 HemY protein N-terminus; Region: HemY_N; pfam07219 536056011987 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 536056011988 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 536056011989 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 536056011990 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 536056011991 active site 536056011992 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 536056011993 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 536056011994 domain interfaces; other site 536056011995 active site 536056011996 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 536056011997 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 536056011998 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 536056011999 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 536056012000 putative iron binding site [ion binding]; other site 536056012001 hypothetical protein; Provisional; Region: PRK09807 536056012002 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 536056012003 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 536056012004 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 536056012005 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 536056012006 hypothetical protein; Provisional; Region: PRK10963 536056012007 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 536056012008 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 536056012009 active site 536056012010 DNA binding site [nucleotide binding] 536056012011 Int/Topo IB signature motif; other site 536056012012 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 536056012013 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536056012014 motif II; other site 536056012015 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 536056012016 Part of AAA domain; Region: AAA_19; pfam13245 536056012017 Family description; Region: UvrD_C_2; pfam13538 536056012018 Predicted periplasmic protein [Function unknown]; Region: COG3698 536056012019 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 536056012020 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 536056012021 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 536056012022 Cl binding site [ion binding]; other site 536056012023 oligomer interface [polypeptide binding]; other site 536056012024 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 536056012025 hypothetical protein; Provisional; Region: PRK11371 536056012026 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 536056012027 EamA-like transporter family; Region: EamA; cl17759 536056012028 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 536056012029 CoenzymeA binding site [chemical binding]; other site 536056012030 subunit interaction site [polypeptide binding]; other site 536056012031 PHB binding site; other site 536056012032 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 536056012033 dimerization interface [polypeptide binding]; other site 536056012034 substrate binding site [chemical binding]; other site 536056012035 active site 536056012036 calcium binding site [ion binding]; other site 536056012037 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 536056012038 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 536056012039 ATP binding site [chemical binding]; other site 536056012040 putative Mg++ binding site [ion binding]; other site 536056012041 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 536056012042 nucleotide binding region [chemical binding]; other site 536056012043 ATP-binding site [chemical binding]; other site 536056012044 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 536056012045 Helicase and RNase D C-terminal; Region: HRDC; smart00341 536056012046 threonine efflux system; Provisional; Region: PRK10229 536056012047 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 536056012048 lysophospholipase L2; Provisional; Region: PRK10749 536056012049 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 536056012050 putative hydrolase; Provisional; Region: PRK10976 536056012051 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536056012052 active site 536056012053 motif I; other site 536056012054 motif II; other site 536056012055 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536056012056 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 536056012057 EamA-like transporter family; Region: EamA; pfam00892 536056012058 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 536056012059 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056012060 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 536056012061 putative dimerization interface [polypeptide binding]; other site 536056012062 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 536056012063 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 536056012064 THF binding site; other site 536056012065 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 536056012066 substrate binding site [chemical binding]; other site 536056012067 THF binding site; other site 536056012068 zinc-binding site [ion binding]; other site 536056012069 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 536056012070 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 536056012071 uridine phosphorylase; Provisional; Region: PRK11178 536056012072 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 536056012073 DNA recombination protein RmuC; Provisional; Region: PRK10361 536056012074 RmuC family; Region: RmuC; pfam02646 536056012075 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 536056012076 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536056012077 S-adenosylmethionine binding site [chemical binding]; other site 536056012078 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 536056012079 SCP-2 sterol transfer family; Region: SCP2; pfam02036 536056012080 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 536056012081 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 536056012082 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 536056012083 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 536056012084 sec-independent translocase; Provisional; Region: PRK01770 536056012085 sec-independent translocase; Provisional; Region: tatB; PRK00404 536056012086 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 536056012087 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 536056012088 active site 536056012089 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 536056012090 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 536056012091 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 536056012092 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 536056012093 FMN reductase; Validated; Region: fre; PRK08051 536056012094 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 536056012095 FAD binding pocket [chemical binding]; other site 536056012096 FAD binding motif [chemical binding]; other site 536056012097 phosphate binding motif [ion binding]; other site 536056012098 beta-alpha-beta structure motif; other site 536056012099 NAD binding pocket [chemical binding]; other site 536056012100 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 536056012101 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 536056012102 dimer interface [polypeptide binding]; other site 536056012103 active site 536056012104 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 536056012105 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 536056012106 substrate binding site [chemical binding]; other site 536056012107 oxyanion hole (OAH) forming residues; other site 536056012108 trimer interface [polypeptide binding]; other site 536056012109 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 536056012110 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 536056012111 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 536056012112 proline dipeptidase; Provisional; Region: PRK13607 536056012113 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 536056012114 active site 536056012115 hypothetical protein; Provisional; Region: PRK11568 536056012116 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 536056012117 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 536056012118 potassium transporter; Provisional; Region: PRK10750 536056012119 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 536056012120 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 536056012121 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 536056012122 Walker A motif; other site 536056012123 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 536056012124 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 536056012125 GTP binding site; other site 536056012126 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 536056012127 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 536056012128 serine/threonine protein kinase; Provisional; Region: PRK11768 536056012129 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 536056012130 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 536056012131 catalytic residues [active] 536056012132 hinge region; other site 536056012133 alpha helical domain; other site 536056012134 hypothetical protein; Provisional; Region: PRK11367 536056012135 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 536056012136 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 536056012137 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 536056012138 putative acyl-acceptor binding pocket; other site 536056012139 DNA polymerase I; Provisional; Region: PRK05755 536056012140 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 536056012141 active site 536056012142 metal binding site 1 [ion binding]; metal-binding site 536056012143 putative 5' ssDNA interaction site; other site 536056012144 metal binding site 3; metal-binding site 536056012145 metal binding site 2 [ion binding]; metal-binding site 536056012146 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 536056012147 putative DNA binding site [nucleotide binding]; other site 536056012148 putative metal binding site [ion binding]; other site 536056012149 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 536056012150 active site 536056012151 catalytic site [active] 536056012152 substrate binding site [chemical binding]; other site 536056012153 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 536056012154 active site 536056012155 DNA binding site [nucleotide binding] 536056012156 catalytic site [active] 536056012157 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 536056012158 G1 box; other site 536056012159 GTP/Mg2+ binding site [chemical binding]; other site 536056012160 Switch I region; other site 536056012161 G2 box; other site 536056012162 G3 box; other site 536056012163 Switch II region; other site 536056012164 G4 box; other site 536056012165 G5 box; other site 536056012166 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 536056012167 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 536056012168 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 536056012169 FeS/SAM binding site; other site 536056012170 HemN C-terminal domain; Region: HemN_C; pfam06969 536056012171 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 536056012172 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536056012173 active site 536056012174 phosphorylation site [posttranslational modification] 536056012175 intermolecular recognition site; other site 536056012176 dimerization interface [polypeptide binding]; other site 536056012177 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536056012178 Walker A motif; other site 536056012179 ATP binding site [chemical binding]; other site 536056012180 Walker B motif; other site 536056012181 arginine finger; other site 536056012182 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 536056012183 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 536056012184 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 536056012185 putative active site [active] 536056012186 heme pocket [chemical binding]; other site 536056012187 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536056012188 dimer interface [polypeptide binding]; other site 536056012189 phosphorylation site [posttranslational modification] 536056012190 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536056012191 ATP binding site [chemical binding]; other site 536056012192 Mg2+ binding site [ion binding]; other site 536056012193 G-X-G motif; other site 536056012194 glutamine synthetase; Provisional; Region: glnA; PRK09469 536056012195 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 536056012196 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 536056012197 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 536056012198 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 536056012199 G1 box; other site 536056012200 putative GEF interaction site [polypeptide binding]; other site 536056012201 GTP/Mg2+ binding site [chemical binding]; other site 536056012202 Switch I region; other site 536056012203 G2 box; other site 536056012204 G3 box; other site 536056012205 Switch II region; other site 536056012206 G4 box; other site 536056012207 G5 box; other site 536056012208 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 536056012209 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 536056012210 transcriptional regulator protein; Region: phnR; TIGR03337 536056012211 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536056012212 DNA-binding site [nucleotide binding]; DNA binding site 536056012213 UTRA domain; Region: UTRA; pfam07702 536056012214 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 536056012215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056012216 putative substrate translocation pore; other site 536056012217 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 536056012218 outer membrane porin L; Provisional; Region: ompL; PRK09980 536056012219 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 536056012220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056012221 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 536056012222 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 536056012223 alpha-glucosidase; Provisional; Region: PRK10426 536056012224 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 536056012225 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 536056012226 putative active site [active] 536056012227 putative catalytic site [active] 536056012228 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 536056012229 active site 536056012230 catalytic residues [active] 536056012231 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 536056012232 dimerization interface [polypeptide binding]; other site 536056012233 putative active cleft [active] 536056012234 Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684 536056012235 catalytic residue [active] 536056012236 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 536056012237 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 536056012238 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 536056012239 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 536056012240 substrate binding site [chemical binding]; other site 536056012241 ATP binding site [chemical binding]; other site 536056012242 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 536056012243 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 536056012244 putative DNA binding site [nucleotide binding]; other site 536056012245 putative Zn2+ binding site [ion binding]; other site 536056012246 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 536056012247 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 536056012248 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536056012249 motif II; other site 536056012250 hypothetical protein; Reviewed; Region: PRK01637 536056012251 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 536056012252 putative active site [active] 536056012253 dimerization interface [polypeptide binding]; other site 536056012254 putative tRNAtyr binding site [nucleotide binding]; other site 536056012255 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536056012256 Coenzyme A binding pocket [chemical binding]; other site 536056012257 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 536056012258 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 536056012259 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 536056012260 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 536056012261 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 536056012262 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 536056012263 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 536056012264 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 536056012265 'formate dehydrogenase-O, large subunit, stop codon appeared; function: Anaerobic dehydrogenases, typically selenocysteine-containing' 536056012266 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 536056012267 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 536056012268 putative frv operon regulatory protein; Provisional; Region: PRK09863 536056012269 HTH domain; Region: HTH_11; pfam08279 536056012270 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 536056012271 active site 536056012272 phosphorylation site [posttranslational modification] 536056012273 putative peptidase; Provisional; Region: PRK09864 536056012274 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 536056012275 oligomer interface [polypeptide binding]; other site 536056012276 active site 536056012277 metal binding site [ion binding]; metal-binding site 536056012278 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 536056012279 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 536056012280 active site 536056012281 P-loop; other site 536056012282 phosphorylation site [posttranslational modification] 536056012283 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 536056012284 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 536056012285 active site 536056012286 phosphorylation site [posttranslational modification] 536056012287 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 536056012288 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 536056012289 intersubunit interface [polypeptide binding]; other site 536056012290 active site 536056012291 Zn2+ binding site [ion binding]; other site 536056012292 L-rhamnose isomerase; Provisional; Region: PRK01076 536056012293 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 536056012294 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 536056012295 N- and C-terminal domain interface [polypeptide binding]; other site 536056012296 active site 536056012297 putative catalytic site [active] 536056012298 metal binding site [ion binding]; metal-binding site 536056012299 ATP binding site [chemical binding]; other site 536056012300 rhamnulokinase; Provisional; Region: rhaB; PRK10640 536056012301 carbohydrate binding site [chemical binding]; other site 536056012302 transcriptional activator RhaS; Provisional; Region: PRK13503 536056012303 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 536056012304 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536056012305 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536056012306 transcriptional activator RhaR; Provisional; Region: PRK13500 536056012307 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 536056012308 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536056012309 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536056012310 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 536056012311 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 536056012312 superoxide dismutase; Provisional; Region: PRK10925 536056012313 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 536056012314 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 536056012315 2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793 536056012316 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 536056012317 MOSC domain; Region: MOSC; pfam03473 536056012318 3-alpha domain; Region: 3-alpha; pfam03475 536056012319 two-component sensor protein; Provisional; Region: cpxA; PRK09470 536056012320 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 536056012321 dimerization interface [polypeptide binding]; other site 536056012322 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536056012323 dimer interface [polypeptide binding]; other site 536056012324 phosphorylation site [posttranslational modification] 536056012325 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536056012326 ATP binding site [chemical binding]; other site 536056012327 Mg2+ binding site [ion binding]; other site 536056012328 G-X-G motif; other site 536056012329 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 536056012330 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536056012331 active site 536056012332 intermolecular recognition site; other site 536056012333 dimerization interface [polypeptide binding]; other site 536056012334 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 536056012335 DNA binding site [nucleotide binding] 536056012336 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 536056012337 dimer interface [polypeptide binding]; other site 536056012338 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 536056012339 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 536056012340 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 536056012341 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 536056012342 active site 536056012343 ADP/pyrophosphate binding site [chemical binding]; other site 536056012344 dimerization interface [polypeptide binding]; other site 536056012345 allosteric effector site; other site 536056012346 fructose-1,6-bisphosphate binding site; other site 536056012347 sulfate transporter subunit; Provisional; Region: PRK10752 536056012348 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 536056012349 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 536056012350 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 536056012351 triosephosphate isomerase; Provisional; Region: PRK14567 536056012352 substrate binding site [chemical binding]; other site 536056012353 dimer interface [polypeptide binding]; other site 536056012354 catalytic triad [active] 536056012355 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 536056012356 Predicted membrane protein [Function unknown]; Region: COG3152 536056012357 hypothetical protein; Provisional; Region: PRK09981 536056012358 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 536056012359 Ligand Binding Site [chemical binding]; other site 536056012360 ferredoxin-NADP reductase; Provisional; Region: PRK10926 536056012361 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 536056012362 FAD binding pocket [chemical binding]; other site 536056012363 FAD binding motif [chemical binding]; other site 536056012364 phosphate binding motif [ion binding]; other site 536056012365 beta-alpha-beta structure motif; other site 536056012366 NAD binding pocket [chemical binding]; other site 536056012367 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 536056012368 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 536056012369 putative active site [active] 536056012370 glycerol kinase; Provisional; Region: glpK; PRK00047 536056012371 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 536056012372 N- and C-terminal domain interface [polypeptide binding]; other site 536056012373 active site 536056012374 MgATP binding site [chemical binding]; other site 536056012375 catalytic site [active] 536056012376 metal binding site [ion binding]; metal-binding site 536056012377 glycerol binding site [chemical binding]; other site 536056012378 homotetramer interface [polypeptide binding]; other site 536056012379 homodimer interface [polypeptide binding]; other site 536056012380 FBP binding site [chemical binding]; other site 536056012381 protein IIAGlc interface [polypeptide binding]; other site 536056012382 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 536056012383 amphipathic channel; other site 536056012384 Asn-Pro-Ala signature motifs; other site 536056012385 septal ring assembly protein ZapB; Provisional; Region: PRK15422 536056012386 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 536056012387 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 536056012388 UbiA prenyltransferase family; Region: UbiA; pfam01040 536056012389 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 536056012390 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536056012391 Walker A motif; other site 536056012392 ATP binding site [chemical binding]; other site 536056012393 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 536056012394 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 536056012395 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 536056012396 active site 536056012397 HslU subunit interaction site [polypeptide binding]; other site 536056012398 essential cell division protein FtsN; Provisional; Region: PRK10927 536056012399 cell division protein FtsN; Provisional; Region: PRK12757 536056012400 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 536056012401 DNA binding site [nucleotide binding] 536056012402 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 536056012403 domain linker motif; other site 536056012404 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 536056012405 dimerization interface [polypeptide binding]; other site 536056012406 ligand binding site [chemical binding]; other site 536056012407 primosome assembly protein PriA; Validated; Region: PRK05580 536056012408 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 536056012409 ATP binding site [chemical binding]; other site 536056012410 putative Mg++ binding site [ion binding]; other site 536056012411 helicase superfamily c-terminal domain; Region: HELICc; smart00490 536056012412 ATP-binding site [chemical binding]; other site 536056012413 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 536056012414 hypothetical protein; Provisional; Region: PRK10030 536056012415 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 536056012416 dimerization interface [polypeptide binding]; other site 536056012417 DNA binding site [nucleotide binding] 536056012418 corepressor binding sites; other site 536056012419 cystathionine gamma-synthase; Provisional; Region: PRK08045 536056012420 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 536056012421 homodimer interface [polypeptide binding]; other site 536056012422 substrate-cofactor binding pocket; other site 536056012423 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056012424 catalytic residue [active] 536056012425 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 536056012426 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 536056012427 putative catalytic residues [active] 536056012428 putative nucleotide binding site [chemical binding]; other site 536056012429 putative aspartate binding site [chemical binding]; other site 536056012430 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 536056012431 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 536056012432 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 536056012433 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 536056012434 FAD binding site [chemical binding]; other site 536056012435 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 536056012436 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 536056012437 heme binding site [chemical binding]; other site 536056012438 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 536056012439 EamA-like transporter family; Region: EamA; pfam00892 536056012440 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 536056012441 EamA-like transporter family; Region: EamA; pfam00892 536056012442 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 536056012443 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 536056012444 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 536056012445 dimer interface [polypeptide binding]; other site 536056012446 active site 536056012447 metal binding site [ion binding]; metal-binding site 536056012448 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 536056012449 active site 536056012450 intersubunit interactions; other site 536056012451 catalytic residue [active] 536056012452 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 536056012453 dimerization domain swap beta strand [polypeptide binding]; other site 536056012454 regulatory protein interface [polypeptide binding]; other site 536056012455 active site 536056012456 regulatory phosphorylation site [posttranslational modification]; other site 536056012457 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 536056012458 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 536056012459 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 536056012460 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 536056012461 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 536056012462 active site 536056012463 phosphorylation site [posttranslational modification] 536056012464 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 536056012465 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 536056012466 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 536056012467 active site 536056012468 P-loop; other site 536056012469 phosphorylation site [posttranslational modification] 536056012470 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 536056012471 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 536056012472 dimer interface [polypeptide binding]; other site 536056012473 active site 536056012474 glycine loop; other site 536056012475 pyruvate formate lyase II activase; Provisional; Region: PRK10076 536056012476 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 536056012477 active site 536056012478 P-loop; other site 536056012479 phosphorylation site [posttranslational modification] 536056012480 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 536056012481 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536056012482 hypothetical protein; Provisional; Region: PRK10649 536056012483 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 536056012484 Sulfatase; Region: Sulfatase; pfam00884 536056012485 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 536056012486 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 536056012487 acetylornithine deacetylase; Provisional; Region: PRK05111 536056012488 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 536056012489 metal binding site [ion binding]; metal-binding site 536056012490 putative dimer interface [polypeptide binding]; other site 536056012491 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 536056012492 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 536056012493 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 536056012494 nucleotide binding site [chemical binding]; other site 536056012495 N-acetyl-L-glutamate binding site [chemical binding]; other site 536056012496 argininosuccinate lyase; Provisional; Region: PRK04833 536056012497 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 536056012498 active sites [active] 536056012499 tetramer interface [polypeptide binding]; other site 536056012500 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 536056012501 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056012502 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 536056012503 dimerization interface [polypeptide binding]; other site 536056012504 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 536056012505 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 536056012506 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 536056012507 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 536056012508 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536056012509 hypothetical protein; Provisional; Region: PRK11056 536056012510 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 536056012511 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536056012512 S-adenosylmethionine binding site [chemical binding]; other site 536056012513 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 536056012514 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 536056012515 N-terminal plug; other site 536056012516 ligand-binding site [chemical binding]; other site 536056012517 glutamate racemase; Provisional; Region: PRK00865 536056012518 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 536056012519 FAD binding domain; Region: FAD_binding_4; pfam01565 536056012520 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 536056012521 Biotin operon repressor [Transcription]; Region: BirA; COG1654 536056012522 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 536056012523 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 536056012524 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 536056012525 pantothenate kinase; Provisional; Region: PRK05439 536056012526 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 536056012527 ATP-binding site [chemical binding]; other site 536056012528 CoA-binding site [chemical binding]; other site 536056012529 Mg2+-binding site [ion binding]; other site 536056012530 elongation factor Tu; Reviewed; Region: PRK00049 536056012531 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 536056012532 G1 box; other site 536056012533 GEF interaction site [polypeptide binding]; other site 536056012534 GTP/Mg2+ binding site [chemical binding]; other site 536056012535 Switch I region; other site 536056012536 G2 box; other site 536056012537 G3 box; other site 536056012538 Switch II region; other site 536056012539 G4 box; other site 536056012540 G5 box; other site 536056012541 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 536056012542 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 536056012543 Antibiotic Binding Site [chemical binding]; other site 536056012544 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 536056012545 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 536056012546 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 536056012547 putative homodimer interface [polypeptide binding]; other site 536056012548 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 536056012549 heterodimer interface [polypeptide binding]; other site 536056012550 homodimer interface [polypeptide binding]; other site 536056012551 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 536056012552 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 536056012553 23S rRNA interface [nucleotide binding]; other site 536056012554 L7/L12 interface [polypeptide binding]; other site 536056012555 putative thiostrepton binding site; other site 536056012556 L25 interface [polypeptide binding]; other site 536056012557 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 536056012558 mRNA/rRNA interface [nucleotide binding]; other site 536056012559 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 536056012560 23S rRNA interface [nucleotide binding]; other site 536056012561 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 536056012562 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 536056012563 core dimer interface [polypeptide binding]; other site 536056012564 peripheral dimer interface [polypeptide binding]; other site 536056012565 L10 interface [polypeptide binding]; other site 536056012566 L11 interface [polypeptide binding]; other site 536056012567 putative EF-Tu interaction site [polypeptide binding]; other site 536056012568 putative EF-G interaction site [polypeptide binding]; other site 536056012569 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 536056012570 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 536056012571 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 536056012572 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 536056012573 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 536056012574 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 536056012575 RPB3 interaction site [polypeptide binding]; other site 536056012576 RPB1 interaction site [polypeptide binding]; other site 536056012577 RPB11 interaction site [polypeptide binding]; other site 536056012578 RPB10 interaction site [polypeptide binding]; other site 536056012579 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 536056012580 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 536056012581 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 536056012582 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 536056012583 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 536056012584 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 536056012585 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 536056012586 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 536056012587 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 536056012588 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 536056012589 DNA binding site [nucleotide binding] 536056012590 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 536056012591 stationary phase growth adaptation protein; Provisional; Region: PRK09717 536056012592 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 536056012593 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 536056012594 FeS/SAM binding site; other site 536056012595 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 536056012596 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 536056012597 ThiS interaction site; other site 536056012598 putative active site [active] 536056012599 tetramer interface [polypeptide binding]; other site 536056012600 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 536056012601 thiS-thiF/thiG interaction site; other site 536056012602 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 536056012603 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 536056012604 ATP binding site [chemical binding]; other site 536056012605 substrate interface [chemical binding]; other site 536056012606 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 536056012607 thiamine phosphate binding site [chemical binding]; other site 536056012608 active site 536056012609 pyrophosphate binding site [ion binding]; other site 536056012610 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 536056012611 ThiC-associated domain; Region: ThiC-associated; pfam13667 536056012612 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 536056012613 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 536056012614 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 536056012615 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 536056012616 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 536056012617 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 536056012618 putative NADH binding site [chemical binding]; other site 536056012619 putative active site [active] 536056012620 nudix motif; other site 536056012621 putative metal binding site [ion binding]; other site 536056012622 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 536056012623 substrate binding site [chemical binding]; other site 536056012624 active site 536056012625 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 536056012626 Active_site [active] 536056012627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 536056012628 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 536056012629 IHF dimer interface [polypeptide binding]; other site 536056012630 IHF - DNA interface [nucleotide binding]; other site 536056012631 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 536056012632 zinc resistance protein; Provisional; Region: zraP; PRK11546 536056012633 dimer interface [polypeptide binding]; other site 536056012634 sensor protein ZraS; Provisional; Region: PRK10364 536056012635 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536056012636 dimer interface [polypeptide binding]; other site 536056012637 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536056012638 ATP binding site [chemical binding]; other site 536056012639 Mg2+ binding site [ion binding]; other site 536056012640 G-X-G motif; other site 536056012641 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 536056012642 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536056012643 active site 536056012644 phosphorylation site [posttranslational modification] 536056012645 intermolecular recognition site; other site 536056012646 dimerization interface [polypeptide binding]; other site 536056012647 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536056012648 Walker A motif; other site 536056012649 ATP binding site [chemical binding]; other site 536056012650 Walker B motif; other site 536056012651 arginine finger; other site 536056012652 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 536056012653 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 536056012654 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 536056012655 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 536056012656 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 536056012657 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 536056012658 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 536056012659 purine monophosphate binding site [chemical binding]; other site 536056012660 dimer interface [polypeptide binding]; other site 536056012661 putative catalytic residues [active] 536056012662 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 536056012663 hypothetical protein; Provisional; Region: PRK10039 536056012664 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 536056012665 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536056012666 Coenzyme A binding pocket [chemical binding]; other site 536056012667 homoserine O-succinyltransferase; Provisional; Region: PRK05368 536056012668 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 536056012669 proposed active site lysine [active] 536056012670 conserved cys residue [active] 536056012671 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 536056012672 malate synthase A; Region: malate_syn_A; TIGR01344 536056012673 active site 536056012674 isocitrate lyase; Provisional; Region: PRK15063 536056012675 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 536056012676 tetramer interface [polypeptide binding]; other site 536056012677 active site 536056012678 Mg2+/Mn2+ binding site [ion binding]; other site 536056012679 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 536056012680 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 536056012681 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 536056012682 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 536056012683 transcriptional repressor IclR; Provisional; Region: PRK11569 536056012684 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 536056012685 Bacterial transcriptional regulator; Region: IclR; pfam01614 536056012686 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 536056012687 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 536056012688 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 536056012689 substrate binding pocket [chemical binding]; other site 536056012690 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 536056012691 B12 binding site [chemical binding]; other site 536056012692 cobalt ligand [ion binding]; other site 536056012693 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 536056012694 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 536056012695 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 536056012696 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 536056012697 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 536056012698 active site pocket [active] 536056012699 oxyanion hole [active] 536056012700 catalytic triad [active] 536056012701 active site nucleophile [active] 536056012702 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 536056012703 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 536056012704 RNA binding surface [nucleotide binding]; other site 536056012705 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 536056012706 probable active site [active] 536056012707 hypothetical protein; Provisional; Region: PRK10515 536056012708 aspartate kinase III; Validated; Region: PRK09084 536056012709 AAK_AKiii-LysC-EC: Amino Acid Kinase Superfamily (AAK), AKiii-LysC-EC: this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKIII. AKIII is a monofunctional class enzyme (LysC) found in some...; Region: AAK_AKiii-LysC-EC; cd04258 536056012710 nucleotide binding site [chemical binding]; other site 536056012711 putative catalytic residues [active] 536056012712 aspartate binding site [chemical binding]; other site 536056012713 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 536056012714 lysine allosteric regulatory site; other site 536056012715 dimer interface [polypeptide binding]; other site 536056012716 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 536056012717 dimer interface [polypeptide binding]; other site 536056012718 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 536056012719 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 536056012720 active site 536056012721 dimer interface [polypeptide binding]; other site 536056012722 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 536056012723 dimer interface [polypeptide binding]; other site 536056012724 active site 536056012725 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 536056012726 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 536056012727 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 536056012728 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 536056012729 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 536056012730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056012731 putative substrate translocation pore; other site 536056012732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056012733 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 536056012734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056012735 dimer interface [polypeptide binding]; other site 536056012736 conserved gate region; other site 536056012737 putative PBP binding loops; other site 536056012738 ABC-ATPase subunit interface; other site 536056012739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056012740 dimer interface [polypeptide binding]; other site 536056012741 conserved gate region; other site 536056012742 putative PBP binding loops; other site 536056012743 ABC-ATPase subunit interface; other site 536056012744 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 536056012745 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 536056012746 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 536056012747 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 536056012748 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 536056012749 Walker A/P-loop; other site 536056012750 ATP binding site [chemical binding]; other site 536056012751 Q-loop/lid; other site 536056012752 ABC transporter signature motif; other site 536056012753 Walker B; other site 536056012754 D-loop; other site 536056012755 H-loop/switch region; other site 536056012756 TOBE domain; Region: TOBE_2; pfam08402 536056012757 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 536056012758 trimer interface; other site 536056012759 sugar binding site [chemical binding]; other site 536056012760 maltose regulon periplasmic protein; Provisional; Region: PRK10564 536056012761 hypothetical protein; Validated; Region: PRK09718 536056012762 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 536056012763 SopA-like central domain; Region: SopA; pfam13981 536056012764 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 536056012765 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 536056012766 UbiA prenyltransferase family; Region: UbiA; pfam01040 536056012767 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 536056012768 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 536056012769 putative acyl-acceptor binding pocket; other site 536056012770 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 536056012771 LexA repressor; Validated; Region: PRK00215 536056012772 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 536056012773 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 536056012774 Catalytic site [active] 536056012775 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 536056012776 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 536056012777 hypothetical protein; Provisional; Region: PRK10428 536056012778 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 536056012779 metal binding site 2 [ion binding]; metal-binding site 536056012780 putative DNA binding helix; other site 536056012781 metal binding site 1 [ion binding]; metal-binding site 536056012782 dimer interface [polypeptide binding]; other site 536056012783 structural Zn2+ binding site [ion binding]; other site 536056012784 Protein of unknown function (DUF2713); Region: DUF2713; pfam10897 536056012785 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 536056012786 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 536056012787 FMN binding site [chemical binding]; other site 536056012788 active site 536056012789 catalytic residues [active] 536056012790 substrate binding site [chemical binding]; other site 536056012791 phage shock protein G; Reviewed; Region: pspG; PRK09459 536056012792 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 536056012793 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 536056012794 NADP binding site [chemical binding]; other site 536056012795 dimer interface [polypeptide binding]; other site 536056012796 replicative DNA helicase; Provisional; Region: PRK08006 536056012797 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 536056012798 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 536056012799 Walker A motif; other site 536056012800 ATP binding site [chemical binding]; other site 536056012801 Walker B motif; other site 536056012802 DNA binding loops [nucleotide binding] 536056012803 alanine racemase; Reviewed; Region: alr; PRK00053 536056012804 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 536056012805 active site 536056012806 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 536056012807 substrate binding site [chemical binding]; other site 536056012808 catalytic residues [active] 536056012809 dimer interface [polypeptide binding]; other site 536056012810 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 536056012811 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 536056012812 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056012813 homodimer interface [polypeptide binding]; other site 536056012814 catalytic residue [active] 536056012815 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536056012816 active site 536056012817 motif I; other site 536056012818 motif II; other site 536056012819 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 536056012820 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 536056012821 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 536056012822 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 536056012823 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 536056012824 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 536056012825 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 536056012826 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 536056012827 dimer interface [polypeptide binding]; other site 536056012828 ssDNA binding site [nucleotide binding]; other site 536056012829 tetramer (dimer of dimers) interface [polypeptide binding]; other site 536056012830 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 536056012831 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 536056012832 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 536056012833 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 536056012834 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 536056012835 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536056012836 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 536056012837 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 536056012838 DNA binding residues [nucleotide binding] 536056012839 dimer interface [polypeptide binding]; other site 536056012840 [2Fe-2S] cluster binding site [ion binding]; other site 536056012841 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 536056012842 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 536056012843 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 536056012844 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 536056012845 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 536056012846 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 536056012847 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 536056012848 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 536056012849 Na binding site [ion binding]; other site 536056012850 Predicted membrane protein [Function unknown]; Region: COG3162 536056012851 acetyl-CoA synthetase; Provisional; Region: PRK00174 536056012852 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 536056012853 active site 536056012854 CoA binding site [chemical binding]; other site 536056012855 acyl-activating enzyme (AAE) consensus motif; other site 536056012856 AMP binding site [chemical binding]; other site 536056012857 acetate binding site [chemical binding]; other site 536056012858 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 536056012859 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 536056012860 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 536056012861 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 536056012862 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 536056012863 heme lyase subunit NrfE; Provisional; Region: PRK10369 536056012864 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 536056012865 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 536056012866 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 536056012867 binding surface 536056012868 TPR motif; other site 536056012869 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 536056012870 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 536056012871 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 536056012872 Sel1-like repeats; Region: SEL1; smart00671 536056012873 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 536056012874 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 536056012875 [4Fe-4S] binding site [ion binding]; other site 536056012876 molybdopterin cofactor binding site; other site 536056012877 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 536056012878 molybdopterin cofactor binding site; other site 536056012879 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 536056012880 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 536056012881 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 536056012882 multidrug resistance protein MdtN; Provisional; Region: PRK10476 536056012883 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 536056012884 HlyD family secretion protein; Region: HlyD_3; pfam13437 536056012885 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 536056012886 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 536056012887 D-allose kinase; Provisional; Region: PRK09698 536056012888 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 536056012889 nucleotide binding site [chemical binding]; other site 536056012890 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 536056012891 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 536056012892 substrate binding site [chemical binding]; other site 536056012893 hexamer interface [polypeptide binding]; other site 536056012894 metal binding site [ion binding]; metal-binding site 536056012895 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536056012896 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536056012897 TM-ABC transporter signature motif; other site 536056012898 D-allose transporter ATP-binding protein; Provisional; Region: PRK09700 536056012899 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536056012900 Walker A/P-loop; other site 536056012901 ATP binding site [chemical binding]; other site 536056012902 Q-loop/lid; other site 536056012903 ABC transporter signature motif; other site 536056012904 Walker B; other site 536056012905 D-loop; other site 536056012906 H-loop/switch region; other site 536056012907 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 536056012908 D-allose transporter subunit; Provisional; Region: PRK09701 536056012909 Periplasmic allose-binding domain of bacterial transport systems that function as a primary receptor of active transport and chemotaxis; Region: PBP1_allose_binding; cd06320 536056012910 ligand binding site [chemical binding]; other site 536056012911 dimerization interface [polypeptide binding]; other site 536056012912 zinc binding site [ion binding]; other site 536056012913 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 536056012914 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 536056012915 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 536056012916 putative active site [active] 536056012917 ribose 5-phosphate isomerase B; Region: rpiB; TIGR01120 536056012918 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 536056012919 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536056012920 Coenzyme A binding pocket [chemical binding]; other site 536056012921 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 536056012922 AAA domain; Region: AAA_18; pfam13238 536056012923 active site 536056012924 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 536056012925 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 536056012926 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 536056012927 active site 536056012928 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 536056012929 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 536056012930 Walker A/P-loop; other site 536056012931 ATP binding site [chemical binding]; other site 536056012932 Q-loop/lid; other site 536056012933 ABC transporter signature motif; other site 536056012934 Walker B; other site 536056012935 D-loop; other site 536056012936 H-loop/switch region; other site 536056012937 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 536056012938 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 536056012939 Walker A/P-loop; other site 536056012940 ATP binding site [chemical binding]; other site 536056012941 Q-loop/lid; other site 536056012942 ABC transporter signature motif; other site 536056012943 Walker B; other site 536056012944 D-loop; other site 536056012945 H-loop/switch region; other site 536056012946 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 536056012947 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 536056012948 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 536056012949 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 536056012950 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 536056012951 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 536056012952 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536056012953 DNA-binding site [nucleotide binding]; DNA binding site 536056012954 UTRA domain; Region: UTRA; pfam07702 536056012955 potential frameshift: common BLAST hit: gi|218692400|ref|YP_002400612.1| phosphonates transport system permease 536056012956 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 536056012957 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 536056012958 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 536056012959 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 536056012960 conserved gate region; other site 536056012961 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 536056012962 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 536056012963 substrate binding pocket [chemical binding]; other site 536056012964 membrane-bound complex binding site; other site 536056012965 hinge residues; other site 536056012966 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 536056012967 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 536056012968 Walker A/P-loop; other site 536056012969 ATP binding site [chemical binding]; other site 536056012970 Q-loop/lid; other site 536056012971 ABC transporter signature motif; other site 536056012972 Walker B; other site 536056012973 D-loop; other site 536056012974 H-loop/switch region; other site 536056012975 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 536056012976 dimer interface [polypeptide binding]; other site 536056012977 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 536056012978 hypothetical protein; Provisional; Region: PRK10220 536056012979 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 536056012980 PhnA protein; Region: PhnA; pfam03831 536056012981 hypothetical protein; Provisional; Region: PRK09866 536056012982 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 536056012983 G1 box; other site 536056012984 GTP/Mg2+ binding site [chemical binding]; other site 536056012985 G2 box; other site 536056012986 Switch I region; other site 536056012987 G3 box; other site 536056012988 Switch II region; other site 536056012989 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 536056012990 G2 box; other site 536056012991 Switch I region; other site 536056012992 G3 box; other site 536056012993 Switch II region; other site 536056012994 G4 box; other site 536056012995 G5 box; other site 536056012996 YjcZ-like protein; Region: YjcZ; pfam13990 536056012997 proline/glycine betaine transporter; Provisional; Region: PRK10642 536056012998 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056012999 putative substrate translocation pore; other site 536056013000 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 536056013001 sensor protein BasS/PmrB; Provisional; Region: PRK10755 536056013002 HAMP domain; Region: HAMP; pfam00672 536056013003 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536056013004 dimer interface [polypeptide binding]; other site 536056013005 phosphorylation site [posttranslational modification] 536056013006 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536056013007 ATP binding site [chemical binding]; other site 536056013008 Mg2+ binding site [ion binding]; other site 536056013009 G-X-G motif; other site 536056013010 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 536056013011 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536056013012 active site 536056013013 phosphorylation site [posttranslational modification] 536056013014 intermolecular recognition site; other site 536056013015 dimerization interface [polypeptide binding]; other site 536056013016 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 536056013017 DNA binding site [nucleotide binding] 536056013018 putative metal dependent hydrolase; Provisional; Region: PRK11598 536056013019 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 536056013020 Sulfatase; Region: Sulfatase; pfam00884 536056013021 arginine:agmatin antiporter; Provisional; Region: PRK10644 536056013022 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 536056013023 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536056013024 arginine decarboxylase; Provisional; Region: PRK15029 536056013025 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 536056013026 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 536056013027 homodimer interface [polypeptide binding]; other site 536056013028 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056013029 catalytic residue [active] 536056013030 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 536056013031 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 536056013032 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536056013033 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536056013034 alpha-galactosidase; Provisional; Region: PRK15076 536056013035 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 536056013036 NAD binding site [chemical binding]; other site 536056013037 sugar binding site [chemical binding]; other site 536056013038 divalent metal binding site [ion binding]; other site 536056013039 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 536056013040 dimer interface [polypeptide binding]; other site 536056013041 melibiose:sodium symporter; Provisional; Region: PRK10429 536056013042 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 536056013043 hypothetical protein; Provisional; Region: PRK09867 536056013044 fumarate hydratase; Provisional; Region: PRK15389 536056013045 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 536056013046 Fumarase C-terminus; Region: Fumerase_C; pfam05683 536056013047 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 536056013048 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 536056013049 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 536056013050 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536056013051 active site 536056013052 phosphorylation site [posttranslational modification] 536056013053 intermolecular recognition site; other site 536056013054 dimerization interface [polypeptide binding]; other site 536056013055 Transcriptional regulator; Region: CitT; pfam12431 536056013056 sensory histidine kinase DcuS; Provisional; Region: PRK11086 536056013057 PAS domain; Region: PAS; smart00091 536056013058 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536056013059 ATP binding site [chemical binding]; other site 536056013060 Mg2+ binding site [ion binding]; other site 536056013061 G-X-G motif; other site 536056013062 Uncharacterized conserved protein [Function unknown]; Region: COG3592 536056013063 Predicted acetyltransferase [General function prediction only]; Region: COG2388 536056013064 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 536056013065 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 536056013066 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 536056013067 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 536056013068 dimer interface [polypeptide binding]; other site 536056013069 putative anticodon binding site; other site 536056013070 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 536056013071 motif 1; other site 536056013072 active site 536056013073 motif 2; other site 536056013074 motif 3; other site 536056013075 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 536056013076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056013077 putative substrate translocation pore; other site 536056013078 POT family; Region: PTR2; pfam00854 536056013079 lysine decarboxylase CadA; Provisional; Region: PRK15400 536056013080 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 536056013081 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 536056013082 homodimer interface [polypeptide binding]; other site 536056013083 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056013084 catalytic residue [active] 536056013085 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 536056013086 'function: Amino acid transporters / transport; Transport of small molecules: Aminoacids, amines; transport of lysine/cadaverine, stop codon appeared' 536056013087 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 536056013088 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 536056013089 DNA binding site [nucleotide binding] 536056013090 putative transcriptional regulator; Provisional; Region: PRK11640 536056013091 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536056013092 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 536056013093 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 536056013094 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 536056013095 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 536056013096 DsbD alpha interface [polypeptide binding]; other site 536056013097 catalytic residues [active] 536056013098 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 536056013099 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 536056013100 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 536056013101 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 536056013102 Aspartase; Region: Aspartase; cd01357 536056013103 active sites [active] 536056013104 tetramer interface [polypeptide binding]; other site 536056013105 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 536056013106 putative transporter; Provisional; Region: PRK11021 536056013107 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 536056013108 oligomerisation interface [polypeptide binding]; other site 536056013109 mobile loop; other site 536056013110 roof hairpin; other site 536056013111 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 536056013112 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 536056013113 ring oligomerisation interface [polypeptide binding]; other site 536056013114 ATP/Mg binding site [chemical binding]; other site 536056013115 stacking interactions; other site 536056013116 hinge regions; other site 536056013117 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 536056013118 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 536056013119 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 536056013120 FeS/SAM binding site; other site 536056013121 elongation factor P; Validated; Region: PRK00529 536056013122 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 536056013123 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 536056013124 RNA binding site [nucleotide binding]; other site 536056013125 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 536056013126 RNA binding site [nucleotide binding]; other site 536056013127 entericidin A; Provisional; Region: PRK09810 536056013128 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 536056013129 multidrug efflux system protein; Provisional; Region: PRK11431 536056013130 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 536056013131 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 536056013132 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 536056013133 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 536056013134 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 536056013135 Iron-sulfur protein interface; other site 536056013136 proximal quinone binding site [chemical binding]; other site 536056013137 C-subunit interface; other site 536056013138 distal quinone binding site; other site 536056013139 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 536056013140 D-subunit interface [polypeptide binding]; other site 536056013141 Iron-sulfur protein interface; other site 536056013142 proximal quinone binding site [chemical binding]; other site 536056013143 distal quinone binding site [chemical binding]; other site 536056013144 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 536056013145 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 536056013146 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 536056013147 L-aspartate oxidase; Provisional; Region: PRK06175 536056013148 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 536056013149 poxB regulator PoxA; Provisional; Region: PRK09350 536056013150 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 536056013151 motif 1; other site 536056013152 dimer interface [polypeptide binding]; other site 536056013153 active site 536056013154 motif 2; other site 536056013155 motif 3; other site 536056013156 inner membrane transporter YjeM; Provisional; Region: PRK15238 536056013157 Protein of unknown function (DUF2645); Region: DUF2645; pfam10840 536056013158 putative mechanosensitive channel protein; Provisional; Region: PRK10929 536056013159 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 536056013160 DNA-binding site [nucleotide binding]; DNA binding site 536056013161 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 536056013162 Mechanosensitive ion channel; Region: MS_channel; pfam00924 536056013163 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 536056013164 GTPase RsgA; Reviewed; Region: PRK12288 536056013165 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 536056013166 RNA binding site [nucleotide binding]; other site 536056013167 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 536056013168 GTPase/Zn-binding domain interface [polypeptide binding]; other site 536056013169 GTP/Mg2+ binding site [chemical binding]; other site 536056013170 G4 box; other site 536056013171 G5 box; other site 536056013172 G1 box; other site 536056013173 Switch I region; other site 536056013174 G2 box; other site 536056013175 G3 box; other site 536056013176 Switch II region; other site 536056013177 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 536056013178 catalytic site [active] 536056013179 putative active site [active] 536056013180 putative substrate binding site [chemical binding]; other site 536056013181 dimer interface [polypeptide binding]; other site 536056013182 epoxyqueuosine reductase; Region: TIGR00276 536056013183 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 536056013184 putative carbohydrate kinase; Provisional; Region: PRK10565 536056013185 yjeF N-terminal region; Region: yjeF_nterm; TIGR00197 536056013186 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 536056013187 putative substrate binding site [chemical binding]; other site 536056013188 putative ATP binding site [chemical binding]; other site 536056013189 ADP-binding protein; Provisional; Region: PRK10646 536056013190 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 536056013191 AMIN domain; Region: AMIN; pfam11741 536056013192 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 536056013193 active site 536056013194 metal binding site [ion binding]; metal-binding site 536056013195 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 536056013196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536056013197 ATP binding site [chemical binding]; other site 536056013198 Mg2+ binding site [ion binding]; other site 536056013199 G-X-G motif; other site 536056013200 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 536056013201 ATP binding site [chemical binding]; other site 536056013202 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 536056013203 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 536056013204 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 536056013205 bacterial Hfq-like; Region: Hfq; cd01716 536056013206 hexamer interface [polypeptide binding]; other site 536056013207 Sm1 motif; other site 536056013208 RNA binding site [nucleotide binding]; other site 536056013209 Sm2 motif; other site 536056013210 GTPase HflX; Provisional; Region: PRK11058 536056013211 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 536056013212 HflX GTPase family; Region: HflX; cd01878 536056013213 G1 box; other site 536056013214 GTP/Mg2+ binding site [chemical binding]; other site 536056013215 Switch I region; other site 536056013216 G2 box; other site 536056013217 G3 box; other site 536056013218 Switch II region; other site 536056013219 G4 box; other site 536056013220 G5 box; other site 536056013221 FtsH protease regulator HflK; Provisional; Region: PRK10930 536056013222 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 536056013223 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 536056013224 FtsH protease regulator HflC; Provisional; Region: PRK11029 536056013225 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 536056013226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 536056013227 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 536056013228 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 536056013229 GDP-binding site [chemical binding]; other site 536056013230 ACT binding site; other site 536056013231 IMP binding site; other site 536056013232 Predicted transcriptional regulator [Transcription]; Region: COG1959 536056013233 transcriptional repressor NsrR; Provisional; Region: PRK11014 536056013234 exoribonuclease R; Provisional; Region: PRK11642 536056013235 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 536056013236 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 536056013237 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 536056013238 RNB domain; Region: RNB; pfam00773 536056013239 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 536056013240 RNA binding site [nucleotide binding]; other site 536056013241 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 536056013242 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 536056013243 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 536056013244 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3789 536056013245 PspA/IM30 family; Region: PspA_IM30; pfam04012 536056013246 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 536056013247 Predicted membrane protein [Function unknown]; Region: COG3766 536056013248 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 536056013249 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 536056013250 Predicted integral membrane protein [Function unknown]; Region: COG5463 536056013251 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 536056013252 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 536056013253 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 536056013254 FAD binding site [chemical binding]; other site 536056013255 substrate binding site [chemical binding]; other site 536056013256 catalytic residues [active] 536056013257 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 536056013258 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 536056013259 esterase; Provisional; Region: PRK10566 536056013260 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 536056013261 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 536056013262 transcriptional repressor UlaR; Provisional; Region: PRK13509 536056013263 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 536056013264 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 536056013265 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 536056013266 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 536056013267 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 536056013268 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 536056013269 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 536056013270 active site 536056013271 P-loop; other site 536056013272 phosphorylation site [posttranslational modification] 536056013273 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 536056013274 active site 536056013275 phosphorylation site [posttranslational modification] 536056013276 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 536056013277 active site 536056013278 dimer interface [polypeptide binding]; other site 536056013279 magnesium binding site [ion binding]; other site 536056013280 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 536056013281 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 536056013282 AP (apurinic/apyrimidinic) site pocket; other site 536056013283 DNA interaction; other site 536056013284 Metal-binding active site; metal-binding site 536056013285 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 536056013286 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 536056013287 intersubunit interface [polypeptide binding]; other site 536056013288 active site 536056013289 Zn2+ binding site [ion binding]; other site 536056013290 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 536056013291 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 536056013292 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 536056013293 dimer interface [polypeptide binding]; other site 536056013294 ssDNA binding site [nucleotide binding]; other site 536056013295 tetramer (dimer of dimers) interface [polypeptide binding]; other site 536056013296 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 536056013297 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 536056013298 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 536056013299 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 536056013300 Protein of unknown function (DUF2686); Region: DUF2686; pfam10887 536056013301 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 536056013302 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 536056013303 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 536056013304 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 536056013305 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 536056013306 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 536056013307 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 536056013308 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 536056013309 Hemerythrin-like domain; Region: Hr-like; cd12108 536056013310 Fe binding site [ion binding]; other site 536056013311 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 536056013312 EamA-like transporter family; Region: EamA; pfam00892 536056013313 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 536056013314 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 536056013315 NADP binding site [chemical binding]; other site 536056013316 Predicted transcriptional regulators [Transcription]; Region: COG1733 536056013317 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 536056013318 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 536056013319 '2':3'-cyclic-nucleotide 2'-phosphodiesterase, stop codon appeared' 536056013320 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 536056013321 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 536056013322 active site 536056013323 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 536056013324 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 536056013325 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 536056013326 Domain of unknown function DUF21; Region: DUF21; pfam01595 536056013327 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 536056013328 Transporter associated domain; Region: CorC_HlyC; smart01091 536056013329 methionine sulfoxide reductase A; Provisional; Region: PRK00058 536056013330 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 536056013331 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 536056013332 Surface antigen; Region: Bac_surface_Ag; pfam01103 536056013333 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 536056013334 Family of unknown function (DUF490); Region: DUF490; pfam04357 536056013335 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 536056013336 putative active site pocket [active] 536056013337 dimerization interface [polypeptide binding]; other site 536056013338 putative catalytic residue [active] 536056013339 hypothetical protein; Provisional; Region: PRK09719 536056013340 antitoxin ChpS; Provisional; Region: PRK11347 536056013341 toxin ChpB; Provisional; Region: PRK09812 536056013342 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 536056013343 dimer interface [polypeptide binding]; other site 536056013344 substrate binding site [chemical binding]; other site 536056013345 metal binding sites [ion binding]; metal-binding site 536056013346 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 536056013347 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 536056013348 putative ligand binding site [chemical binding]; other site 536056013349 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 536056013350 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 536056013351 Walker A/P-loop; other site 536056013352 ATP binding site [chemical binding]; other site 536056013353 Q-loop/lid; other site 536056013354 ABC transporter signature motif; other site 536056013355 Walker B; other site 536056013356 D-loop; other site 536056013357 H-loop/switch region; other site 536056013358 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 536056013359 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536056013360 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536056013361 TM-ABC transporter signature motif; other site 536056013362 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 536056013363 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 536056013364 TM-ABC transporter signature motif; other site 536056013365 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 536056013366 AMP binding site [chemical binding]; other site 536056013367 metal binding site [ion binding]; metal-binding site 536056013368 active site 536056013369 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 536056013370 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 536056013371 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 536056013372 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 536056013373 hypothetical protein; Provisional; Region: PRK05255 536056013374 peptidase PmbA; Provisional; Region: PRK11040 536056013375 Cytochrome b562; Region: Cytochrom_B562; cl01546 536056013376 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 536056013377 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 536056013378 FeS/SAM binding site; other site 536056013379 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 536056013380 ATP cone domain; Region: ATP-cone; pfam03477 536056013381 Class III ribonucleotide reductase; Region: RNR_III; cd01675 536056013382 effector binding site; other site 536056013383 active site 536056013384 Zn binding site [ion binding]; other site 536056013385 glycine loop; other site 536056013386 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 536056013387 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 536056013388 Ca binding site [ion binding]; other site 536056013389 active site 536056013390 catalytic site [active] 536056013391 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 536056013392 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 536056013393 active site turn [active] 536056013394 phosphorylation site [posttranslational modification] 536056013395 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 536056013396 trehalose repressor; Provisional; Region: treR; PRK09492 536056013397 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 536056013398 DNA binding site [nucleotide binding] 536056013399 domain linker motif; other site 536056013400 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 536056013401 dimerization interface [polypeptide binding]; other site 536056013402 ligand binding site [chemical binding]; other site 536056013403 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 536056013404 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 536056013405 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 536056013406 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 536056013407 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536056013408 motif II; other site 536056013409 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 536056013410 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 536056013411 homotrimer interaction site [polypeptide binding]; other site 536056013412 putative active site [active] 536056013413 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 536056013414 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 536056013415 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 536056013416 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 536056013417 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 536056013418 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 536056013419 PyrBI operon leader peptide; Region: PyrBI_leader; pfam08052 536056013420 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 536056013421 homotrimer interaction site [polypeptide binding]; other site 536056013422 putative active site [active] 536056013423 oxidoreductase; Provisional; Region: PRK12742 536056013424 classical (c) SDRs; Region: SDR_c; cd05233 536056013425 NAD(P) binding site [chemical binding]; other site 536056013426 active site 536056013427 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 536056013428 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 536056013429 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 536056013430 SopA-like central domain; Region: SopA; pfam13981 536056013431 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 536056013432 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 536056013433 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 536056013434 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 536056013435 RNase E inhibitor protein; Provisional; Region: PRK11191 536056013436 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 536056013437 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536056013438 Coenzyme A binding pocket [chemical binding]; other site 536056013439 Predicted membrane protein [Function unknown]; Region: COG4269 536056013440 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 536056013441 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 536056013442 HIGH motif; other site 536056013443 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 536056013444 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 536056013445 active site 536056013446 KMSKS motif; other site 536056013447 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 536056013448 tRNA binding surface [nucleotide binding]; other site 536056013449 anticodon binding site; other site 536056013450 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 536056013451 DNA polymerase III subunit chi; Validated; Region: PRK05728 536056013452 multifunctional aminopeptidase A; Provisional; Region: PRK00913 536056013453 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 536056013454 interface (dimer of trimers) [polypeptide binding]; other site 536056013455 Substrate-binding/catalytic site; other site 536056013456 Zn-binding sites [ion binding]; other site 536056013457 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 536056013458 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 536056013459 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 536056013460 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 536056013461 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 536056013462 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 536056013463 Walker A motif; other site 536056013464 ATP binding site [chemical binding]; other site 536056013465 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 536056013466 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 536056013467 DNA binding site [nucleotide binding] 536056013468 domain linker motif; other site 536056013469 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 536056013470 putative dimerization interface [polypeptide binding]; other site 536056013471 putative ligand binding site [chemical binding]; other site 536056013472 fructuronate transporter; Provisional; Region: PRK10034; cl15264 536056013473 gluconate transporter; Region: gntP; TIGR00791 536056013474 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 536056013475 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 536056013476 NADP binding site [chemical binding]; other site 536056013477 homodimer interface [polypeptide binding]; other site 536056013478 active site 536056013479 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 536056013480 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 536056013481 putative NAD(P) binding site [chemical binding]; other site 536056013482 catalytic Zn binding site [ion binding]; other site 536056013483 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 536056013484 ATP-binding site [chemical binding]; other site 536056013485 Gluconate-6-phosphate binding site [chemical binding]; other site 536056013486 Shikimate kinase; Region: SKI; pfam01202 536056013487 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 536056013488 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 536056013489 putative NAD(P) binding site [chemical binding]; other site 536056013490 putative substrate binding site [chemical binding]; other site 536056013491 catalytic Zn binding site [ion binding]; other site 536056013492 structural Zn binding site [ion binding]; other site 536056013493 dimer interface [polypeptide binding]; other site 536056013494 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 536056013495 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 536056013496 active site 536056013497 Int/Topo IB signature motif; other site 536056013498 IS2 repressor TnpA; Reviewed; Region: PRK09413 536056013499 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 536056013500 IS2 transposase TnpB; Reviewed; Region: PRK09409 536056013501 HTH-like domain; Region: HTH_21; pfam13276 536056013502 Integrase core domain; Region: rve; pfam00665 536056013503 Integrase core domain; Region: rve_3; pfam13683 536056013504 potential frameshift: common BLAST hit: gi|218698020|ref|YP_002405687.1| membrane-associated, metal-dependent hydrolase 536056013505 Sulfatase; Region: Sulfatase; cl17466 536056013506 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 536056013507 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 536056013508 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 536056013509 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 536056013510 putative sialic acid transporter; Provisional; Region: PRK12307 536056013511 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056013512 putative substrate translocation pore; other site 536056013513 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 536056013514 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 536056013515 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 536056013516 D-galactonate transporter; Region: 2A0114; TIGR00893 536056013517 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 536056013518 Transposase; Region: HTH_Tnp_1; cl17663 536056013519 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 536056013520 Helix-turn-helix domain; Region: HTH_38; pfam13936 536056013521 Integrase core domain; Region: rve; pfam00665 536056013522 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 536056013523 Transposase; Region: HTH_Tnp_1; pfam01527 536056013524 HTH-like domain; Region: HTH_21; pfam13276 536056013525 Integrase core domain; Region: rve; pfam00665 536056013526 Integrase core domain; Region: rve_3; pfam13683 536056013527 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 536056013528 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 536056013529 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 536056013530 Walker A/P-loop; other site 536056013531 ATP binding site [chemical binding]; other site 536056013532 Q-loop/lid; other site 536056013533 ABC transporter signature motif; other site 536056013534 Walker B; other site 536056013535 D-loop; other site 536056013536 H-loop/switch region; other site 536056013537 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 536056013538 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 536056013539 ABC-ATPase subunit interface; other site 536056013540 dimer interface [polypeptide binding]; other site 536056013541 putative PBP binding regions; other site 536056013542 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 536056013543 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 536056013544 dimer interface [polypeptide binding]; other site 536056013545 ABC-ATPase subunit interface; other site 536056013546 putative PBP binding regions; other site 536056013547 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 536056013548 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 536056013549 siderophore binding site; other site 536056013550 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 536056013551 Secretin and TonB N terminus short domain; Region: STN; smart00965 536056013552 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 536056013553 N-terminal plug; other site 536056013554 ligand-binding site [chemical binding]; other site 536056013555 fec operon regulator FecR; Reviewed; Region: PRK09774 536056013556 FecR protein; Region: FecR; pfam04773 536056013557 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 536056013558 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 536056013559 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 536056013560 DNA binding residues [nucleotide binding] 536056013561 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 536056013562 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 536056013563 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 536056013564 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 536056013565 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 536056013566 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 536056013567 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 536056013568 DNA binding residues [nucleotide binding] 536056013569 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 536056013570 gluconate transporter; Region: gntP; TIGR00791 536056013571 fructuronate transporter; Provisional; Region: PRK10034; cl15264 536056013572 putative dehydratase; Provisional; Region: PRK08211 536056013573 Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism / Carbohydrate transport and metabolism]; Region: IlvD; COG0129 536056013574 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 536056013575 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 536056013576 inhibitor site; inhibition site 536056013577 active site 536056013578 dimer interface [polypeptide binding]; other site 536056013579 catalytic residue [active] 536056013580 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 536056013581 Transcriptional regulator [Transcription]; Region: IclR; COG1414 536056013582 Bacterial transcriptional regulator; Region: IclR; pfam01614 536056013583 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 536056013584 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 536056013585 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 536056013586 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 536056013587 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 536056013588 substrate binding site [chemical binding]; other site 536056013589 hexamer interface [polypeptide binding]; other site 536056013590 metal binding site [ion binding]; metal-binding site 536056013591 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 536056013592 active site 536056013593 phosphorylation site [posttranslational modification] 536056013594 membrane complex biogenesis protein, BtpA family; Region: thylakoid_BtpA; TIGR00259 536056013595 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 536056013596 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 536056013597 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 536056013598 active site 536056013599 P-loop; other site 536056013600 phosphorylation site [posttranslational modification] 536056013601 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 536056013602 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 536056013603 oligomer interface [polypeptide binding]; other site 536056013604 active site 536056013605 metal binding site [ion binding]; metal-binding site 536056013606 Methyltransferase domain; Region: Methyltransf_31; pfam13847 536056013607 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536056013608 S-adenosylmethionine binding site [chemical binding]; other site 536056013609 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 536056013610 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536056013611 Coenzyme A binding pocket [chemical binding]; other site 536056013612 hypothetical protein; Provisional; Region: PRK13687 536056013613 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 536056013614 AAA domain; Region: AAA_12; pfam13087 536056013615 C-terminal domain of Escherichia coli uncharacterized protein yjhR and similar proteins; Region: PLDc_yjhR_C_like; cd09118 536056013616 putative active site [active] 536056013617 catalytic site [active] 536056013618 Domain of unknown function (DUF303); Region: DUF303; pfam03629 536056013619 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 536056013620 Kelch motif; Region: Kelch_1; pfam01344 536056013621 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 536056013622 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 536056013623 Int/Topo IB signature motif; other site 536056013624 'tyrosine recombinase/inversion of on/off regulator of fimA, missing start codon due to deletion' 536056013625 Fimbrial protein; Region: Fimbrial; cl01416 536056013626 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 536056013627 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 536056013628 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 536056013629 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 536056013630 outer membrane usher protein; Provisional; Region: PRK15193 536056013631 PapC N-terminal domain; Region: PapC_N; pfam13954 536056013632 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 536056013633 PapC C-terminal domain; Region: PapC_C; pfam13953 536056013634 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 536056013635 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 536056013636 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 536056013637 mannosyl binding site [chemical binding]; other site 536056013638 Fimbrial protein; Region: Fimbrial; pfam00419 536056013639 fructuronate transporter; Provisional; Region: PRK10034 536056013640 gluconate transporter; Region: gntP; TIGR00791 536056013641 mannonate dehydratase; Region: uxuA; TIGR00695 536056013642 mannonate dehydratase; Provisional; Region: PRK03906 536056013643 D-mannonate oxidoreductase; Provisional; Region: PRK15037 536056013644 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 536056013645 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 536056013646 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 536056013647 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536056013648 DNA-binding site [nucleotide binding]; DNA binding site 536056013649 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 536056013650 Protein of unknown function (DUF2686); Region: DUF2686; pfam10887 536056013651 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 536056013652 cell density-dependent motility repressor; Provisional; Region: PRK10082 536056013653 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 536056013654 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 536056013655 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 536056013656 isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975 536056013657 dimer interface [polypeptide binding]; other site 536056013658 active site 536056013659 hypothetical protein; Provisional; Region: PRK10519 536056013660 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 536056013661 Nucleoside recognition; Region: Gate; pfam07670 536056013662 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 536056013663 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 536056013664 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 536056013665 SdiA-regulated; Region: SdiA-regulated; pfam06977 536056013666 SdiA-regulated; Region: SdiA-regulated; cd09971 536056013667 putative active site [active] 536056013668 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 536056013669 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 536056013670 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 536056013671 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 536056013672 Predicted membrane protein [Function unknown]; Region: COG2733 536056013673 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 536056013674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056013675 putative substrate translocation pore; other site 536056013676 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 536056013677 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 536056013678 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 536056013679 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536056013680 DNA-binding site [nucleotide binding]; DNA binding site 536056013681 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 536056013682 pyridoxal 5'-phosphate binding site [chemical binding]; other site 536056013683 homodimer interface [polypeptide binding]; other site 536056013684 catalytic residue [active] 536056013685 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 536056013686 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 536056013687 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 536056013688 5-methylcytosine-specific restriction enzyme subunit McrC; Provisional; Region: PRK09736 536056013689 5-methylcytosine-specific restriction enzyme subunit McrB; Provisional; Region: PRK11331 536056013690 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 536056013691 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536056013692 Walker A motif; other site 536056013693 ATP binding site [chemical binding]; other site 536056013694 Walker B motif; other site 536056013695 arginine finger; other site 536056013696 endoribonuclease SymE; Provisional; Region: PRK13605 536056013697 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 536056013698 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 536056013699 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 536056013700 HsdM N-terminal domain; Region: HsdM_N; pfam12161 536056013701 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 536056013702 Methyltransferase domain; Region: Methyltransf_26; pfam13659 536056013703 'endonuclease R, stop codon appeared; function: enzyme; Degradation of DNA' 536056013704 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 536056013705 Mrr N-terminal domain; Region: Mrr_N; pfam14338 536056013706 Restriction endonuclease; Region: Mrr_cat; pfam04471 536056013707 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 536056013708 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 536056013709 P-loop, Walker A motif; other site 536056013710 Base recognition motif; other site 536056013711 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 536056013712 Uncharacterized small protein [Function unknown]; Region: COG2879 536056013713 carbon starvation protein A; Provisional; Region: PRK15015 536056013714 Carbon starvation protein CstA; Region: CstA; pfam02554 536056013715 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 536056013716 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 536056013717 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 536056013718 dimer interface [polypeptide binding]; other site 536056013719 ligand binding site [chemical binding]; other site 536056013720 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 536056013721 dimerization interface [polypeptide binding]; other site 536056013722 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 536056013723 dimer interface [polypeptide binding]; other site 536056013724 putative CheW interface [polypeptide binding]; other site 536056013725 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 536056013726 D-galactonate transporter; Region: 2A0114; TIGR00893 536056013727 putative substrate translocation pore; other site 536056013728 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 536056013729 DNA-binding site [nucleotide binding]; DNA binding site 536056013730 Transcriptional regulators [Transcription]; Region: GntR; COG1802 536056013731 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 536056013732 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 536056013733 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 536056013734 putative NAD(P) binding site [chemical binding]; other site 536056013735 catalytic Zn binding site [ion binding]; other site 536056013736 structural Zn binding site [ion binding]; other site 536056013737 phosphoglycerol transferase I; Provisional; Region: PRK03776 536056013738 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 536056013739 hypothetical protein; Provisional; Region: PRK11667 536056013740 DNA replication protein DnaC; Validated; Region: PRK07952 536056013741 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 536056013742 Walker A motif; other site 536056013743 ATP binding site [chemical binding]; other site 536056013744 Walker B motif; other site 536056013745 primosomal protein DnaI; Provisional; Region: PRK02854 536056013746 hypothetical protein; Provisional; Region: PRK09917 536056013747 Uncharacterized conserved protein [Function unknown]; Region: COG2966 536056013748 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 536056013749 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 536056013750 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536056013751 DNA binding residues [nucleotide binding] 536056013752 dimerization interface [polypeptide binding]; other site 536056013753 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 536056013754 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 536056013755 DNA binding residues [nucleotide binding] 536056013756 dimerization interface [polypeptide binding]; other site 536056013757 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 536056013758 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 536056013759 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 536056013760 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 536056013761 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 536056013762 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 536056013763 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 536056013764 S-adenosylmethionine binding site [chemical binding]; other site 536056013765 DNA polymerase III subunit psi; Validated; Region: PRK06856 536056013766 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 536056013767 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 536056013768 Coenzyme A binding pocket [chemical binding]; other site 536056013769 dUMP phosphatase; Provisional; Region: PRK09449 536056013770 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536056013771 motif II; other site 536056013772 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 536056013773 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 536056013774 G1 box; other site 536056013775 putative GEF interaction site [polypeptide binding]; other site 536056013776 GTP/Mg2+ binding site [chemical binding]; other site 536056013777 Switch I region; other site 536056013778 G2 box; other site 536056013779 G3 box; other site 536056013780 Switch II region; other site 536056013781 G4 box; other site 536056013782 G5 box; other site 536056013783 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 536056013784 periplasmic protein; Provisional; Region: PRK10568 536056013785 BON domain; Region: BON; pfam04972 536056013786 BON domain; Region: BON; pfam04972 536056013787 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 536056013788 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 536056013789 active site 536056013790 nucleophile elbow; other site 536056013791 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 536056013792 active site 536056013793 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 536056013794 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 536056013795 FeS/SAM binding site; other site 536056013796 hypothetical protein; Provisional; Region: PRK10977 536056013797 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 536056013798 intersubunit interface [polypeptide binding]; other site 536056013799 active site 536056013800 catalytic residue [active] 536056013801 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 536056013802 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 536056013803 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 536056013804 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 536056013805 phosphopentomutase; Provisional; Region: PRK05362 536056013806 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 536056013807 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 536056013808 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 536056013809 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 536056013810 HipA-like N-terminal domain; Region: HipA_N; pfam07805 536056013811 HipA-like C-terminal domain; Region: HipA_C; pfam07804 536056013812 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 536056013813 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 536056013814 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 536056013815 hypothetical protein; Provisional; Region: PRK11246 536056013816 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 536056013817 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 536056013818 motif II; other site 536056013819 DNA repair protein RadA; Region: sms; TIGR00416 536056013820 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 536056013821 Walker A motif/ATP binding site; other site 536056013822 ATP binding site [chemical binding]; other site 536056013823 Walker B motif; other site 536056013824 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 536056013825 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 536056013826 non-specific DNA binding site [nucleotide binding]; other site 536056013827 salt bridge; other site 536056013828 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 536056013829 sequence-specific DNA binding site [nucleotide binding]; other site 536056013830 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 536056013831 active site 536056013832 (T/H)XGH motif; other site 536056013833 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 536056013834 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 536056013835 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 536056013836 Walker A/P-loop; other site 536056013837 ATP binding site [chemical binding]; other site 536056013838 Q-loop/lid; other site 536056013839 ABC transporter signature motif; other site 536056013840 Walker B; other site 536056013841 D-loop; other site 536056013842 H-loop/switch region; other site 536056013843 ABC transporter; Region: ABC_tran_2; pfam12848 536056013844 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 536056013845 lytic murein transglycosylase; Provisional; Region: PRK11619 536056013846 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 536056013847 N-acetyl-D-glucosamine binding site [chemical binding]; other site 536056013848 catalytic residue [active] 536056013849 Trp operon repressor; Provisional; Region: PRK01381 536056013850 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 536056013851 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 536056013852 catalytic core [active] 536056013853 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 536056013854 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 536056013855 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 536056013856 hypothetical protein; Provisional; Region: PRK10756 536056013857 CreA protein; Region: CreA; pfam05981 536056013858 DNA-binding response regulator CreB; Provisional; Region: PRK11083 536056013859 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536056013860 active site 536056013861 phosphorylation site [posttranslational modification] 536056013862 intermolecular recognition site; other site 536056013863 dimerization interface [polypeptide binding]; other site 536056013864 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 536056013865 DNA binding site [nucleotide binding] 536056013866 sensory histidine kinase CreC; Provisional; Region: PRK11100 536056013867 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 536056013868 dimerization interface [polypeptide binding]; other site 536056013869 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 536056013870 dimer interface [polypeptide binding]; other site 536056013871 phosphorylation site [posttranslational modification] 536056013872 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 536056013873 ATP binding site [chemical binding]; other site 536056013874 Mg2+ binding site [ion binding]; other site 536056013875 G-X-G motif; other site 536056013876 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 536056013877 two-component response regulator; Provisional; Region: PRK11173 536056013878 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 536056013879 active site 536056013880 phosphorylation site [posttranslational modification] 536056013881 intermolecular recognition site; other site 536056013882 dimerization interface [polypeptide binding]; other site 536056013883 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 536056013884 DNA binding site [nucleotide binding] 536056013885 putative RNA methyltransferase; Provisional; Region: PRK10433 536056013886 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050