-- dump date 20140619_082052 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type YP_002396091.1 218687879 7143201 35..2497 1 NC_011745.1 multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartokinase I/homoserine dehydrogenase I 2497 thrA 7143201 thrA Escherichia coli ED1a bifunctional aspartokinase I/homoserine dehydrogenase I YP_002396091.1 35 D 585397 CDS YP_002396092.1 218687880 7141551 2499..3431 1 NC_011745.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 3431 thrB 7141551 thrB Escherichia coli ED1a homoserine kinase YP_002396092.1 2499 D 585397 CDS YP_002396093.1 218687881 7141552 3432..4718 1 NC_011745.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 4718 thrC 7141552 thrC Escherichia coli ED1a threonine synthase YP_002396093.1 3432 D 585397 CDS YP_002396094.1 218687882 7141553 4932..5228 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5228 yaaX 7141553 yaaX Escherichia coli ED1a hypothetical protein YP_002396094.1 4932 D 585397 CDS YP_002396095.1 218687883 7143358 complement(5278..6054) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 6054 yaaA 7143358 yaaA Escherichia coli ED1a hypothetical protein YP_002396095.1 5278 R 585397 CDS YP_002396096.1 218687884 7139220 complement(6124..7554) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative amino acid sodium/proton transporter 7554 yaaJ 7139220 yaaJ Escherichia coli ED1a putative amino acid sodium/proton transporter YP_002396096.1 6124 R 585397 CDS YP_002396097.1 218687885 7143356 7833..8786 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8332529, 92334977, 11298760, 7592346, 8805555, 9007983, 9298646; Product type e : enzyme; transaldolase B 8786 talB 7143356 talB Escherichia coli ED1a transaldolase B YP_002396097.1 7833 D 585397 CDS YP_002396098.1 218687886 7141507 8901..9488 1 NC_011745.1 forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MogA 9488 mogA 7141507 mogA Escherichia coli ED1a molybdenum cofactor biosynthesis protein MogA YP_002396098.1 8901 D 585397 CDS YP_002396099.1 218687887 7139011 complement(9693..10259) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 10259 yaaH 7139011 yaaH Escherichia coli ED1a hypothetical protein YP_002396099.1 9693 R 585397 CDS YP_002396100.1 218687888 7141407 complement(10408..11121) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8478327; Product type r : regulator; hypothetical protein 11121 htpY 7141407 htpY Escherichia coli ED1a hypothetical protein YP_002396100.1 10408 R 585397 CDS YP_002396101.1 218687889 7140174 complement(11147..11551) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 11551 yaaI 7140174 yaaI Escherichia coli ED1a hypothetical protein YP_002396101.1 11147 R 585397 CDS YP_002396102.1 218687890 7143355 11923..13839 1 NC_011745.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 13839 dnaK 7143355 dnaK Escherichia coli ED1a molecular chaperone DnaK YP_002396102.1 11923 D 585397 CDS YP_002396103.1 218687891 7140743 13928..15058 1 NC_011745.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 15058 dnaJ 7140743 dnaJ Escherichia coli ED1a chaperone protein DnaJ YP_002396103.1 13928 D 585397 CDS YP_002396104.1 218687892 7143819 15930..16691 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 16691 7143819 ECED1_0015 Escherichia coli ED1a hypothetical protein YP_002396104.1 15930 D 585397 CDS YP_002396105.1 218687893 7142828 16675..18204 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Cerebroside-sulfatase 18204 7142828 ECED1_0016 Escherichia coli ED1a putative Cerebroside-sulfatase YP_002396105.1 16675 D 585397 CDS YP_002396106.1 218687894 7142829 18327..19592 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 19592 7142829 ECED1_0017 Escherichia coli ED1a hypothetical protein YP_002396106.1 18327 D 585397 CDS YP_002396107.1 218687895 7142830 19827..20993 1 NC_011745.1 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH; pH-dependent sodium/proton antiporter 20993 nhaA 7142830 nhaA Escherichia coli ED1a pH-dependent sodium/proton antiporter YP_002396107.1 19827 D 585397 CDS YP_002396108.1 218687896 7140382 21053..21958 1 NC_011745.1 Na+/H+ antiporter regulatory protein; activates the genes nhaA and osmC; transcriptional activator NhaR 21958 nhaR 7140382 nhaR Escherichia coli ED1a transcriptional activator NhaR YP_002396108.1 21053 D 585397 CDS YP_002396109.1 218687897 7140384 complement(22054..22317) 1 NC_011745.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 22317 rpsT 7140384 rpsT Escherichia coli ED1a 30S ribosomal protein S20 YP_002396109.1 22054 R 585397 CDS YP_002396110.1 218687898 7140103 22420..22638 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 22638 yaaY 7140103 yaaY Escherichia coli ED1a hypothetical protein YP_002396110.1 22420 D 585397 CDS YP_002396111.1 218687899 7143359 22646..23587 1 NC_011745.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 23587 ribF 7143359 ribF Escherichia coli ED1a bifunctional riboflavin kinase/FMN adenylyltransferase YP_002396111.1 22646 D 585397 CDS YP_002396112.1 218687900 7141412 23630..26446 1 NC_011745.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 26446 ileS 7141412 ileS Escherichia coli ED1a isoleucyl-tRNA synthetase YP_002396112.1 23630 D 585397 CDS YP_002396113.1 218687901 7140234 26446..26940 1 NC_011745.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 26940 lspA 7140234 lspA Escherichia coli ED1a lipoprotein signal peptidase YP_002396113.1 26446 D 585397 CDS YP_002396114.1 218687902 7141927 27048..27497 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 97332650, 2011499; Product type e : enzyme; FKBP-type peptidyl-prolyl cis-trans isomerase 27497 fkpB 7141927 fkpB Escherichia coli ED1a FKBP-type peptidyl-prolyl cis-trans isomerase YP_002396114.1 27048 D 585397 CDS YP_002396115.1 218687903 7144195 27499..28449 1 NC_011745.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 28449 ispH 7144195 ispH Escherichia coli ED1a 4-hydroxy-3-methylbut-2-enyl diphosphate reductase YP_002396115.1 27499 D 585397 CDS YP_002396116.1 218687904 7142468 28515..29429 1 NC_011745.1 catalyzes the hydrolysis of both purine and pyrimidine ribonucleosides; ribonucleoside hydrolase RihC 29429 rihC 7142468 rihC Escherichia coli ED1a ribonucleoside hydrolase RihC YP_002396116.1 28515 D 585397 CDS YP_002396117.1 218687905 7141415 29452..29817 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 29817 7141415 ECED1_0028 Escherichia coli ED1a hypothetical protein YP_002396117.1 29452 D 585397 CDS YP_002396118.1 218687906 7142831 29978..30799 1 NC_011745.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 30799 dapB 7142831 dapB Escherichia coli ED1a dihydrodipicolinate reductase YP_002396118.1 29978 D 585397 CDS YP_002396119.1 218687907 7143063 31255..32403 1 NC_011745.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 32403 carA 7143063 carA Escherichia coli ED1a carbamoyl phosphate synthase small subunit YP_002396119.1 31255 D 585397 CDS YP_002396120.1 218687908 7139306 32421..35642 1 NC_011745.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 35642 carB 7139306 carB Escherichia coli ED1a carbamoyl phosphate synthase large subunit YP_002396120.1 32421 D 585397 CDS YP_002396121.1 218687909 7139307 complement(35650..35868) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7815937, 6308632; hypothetical protein 35868 7139307 ECED1_0032 Escherichia coli ED1a hypothetical protein YP_002396121.1 35650 R 585397 CDS YP_002396122.1 218687910 7142832 35903..36298 1 NC_011745.1 regulator of carnitine metabolism; induces the caiTABCDE and fixABCX operons; DNA-binding transcriptional activator CaiF 36298 caiF 7142832 caiF Escherichia coli ED1a DNA-binding transcriptional activator CaiF YP_002396122.1 35903 D 585397 CDS YP_002396123.1 218687911 7140485 complement(36417..37007) 1 NC_011745.1 involved in the synthesis of a cofactor required for carnitine dehydratase and carnitine racemase activities; carnitine operon protein CaiE 37007 caiE 7140485 caiE Escherichia coli ED1a carnitine operon protein CaiE YP_002396123.1 36417 R 585397 CDS YP_002396124.2 229598866 7140484 complement(37013..37798) 1 NC_011745.1 catalyzes the dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA; carnitinyl-CoA dehydratase 37798 caiD 7140484 caiD Escherichia coli ED1a carnitinyl-CoA dehydratase YP_002396124.2 37013 R 585397 CDS YP_002396125.1 218687913 7140483 complement(37904..39472) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15731894, 97189569, 7815937; Product type e : enzyme; putative crotonobetaine/carnitine-CoA ligase 39472 caiC 7140483 caiC Escherichia coli ED1a putative crotonobetaine/carnitine-CoA ligase YP_002396125.1 37904 R 585397 CDS YP_002396126.1 218687914 7140482 complement(39530..40747) 1 NC_011745.1 catalyzes formation of L-carnitinyl-CoA by transfering the CoA moiety from gamma-butyrobetainyl-CoA, also catalyzes the formation of crotonobetainyl-CoA by transfer of CoA from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine; crotonobetainyl-CoA:carnitine CoA-transferase 40747 caiB 7140482 caiB Escherichia coli ED1a crotonobetainyl-CoA:carnitine CoA-transferase YP_002396126.1 39530 R 585397 CDS YP_002396127.1 218687915 7140481 complement(40875..42017) 1 NC_011745.1 catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA; crotonobetainyl-CoA dehydrogenase 42017 caiA 7140481 caiA Escherichia coli ED1a crotonobetainyl-CoA dehydrogenase YP_002396127.1 40875 R 585397 CDS YP_002396128.1 218687916 7140480 complement(42048..43562) 1 NC_011745.1 catalyzes the exchange of L-carnitine for gamma-butyrobetaine in carnitine metabolism; L-carnitine/gamma-butyrobetaine antiporter 43562 caiT 7140480 caiT Escherichia coli ED1a L-carnitine/gamma-butyrobetaine antiporter YP_002396128.1 42048 R 585397 CDS YP_002396129.1 218687917 7141101 44036..44806 1 NC_011745.1 required for anaerobic carnitine reduction, may act to transfer electrons to crotonobetaine reductase; putative electron transfer flavoprotein FixA 44806 fixA 7141101 fixA Escherichia coli ED1a putative electron transfer flavoprotein FixA YP_002396129.1 44036 D 585397 CDS YP_002396130.1 218687918 7144189 44821..45762 1 NC_011745.1 involved in electron transfer during carnitine metabolism; putative electron transfer flavoprotein FixB 45762 fixB 7144189 fixB Escherichia coli ED1a putative electron transfer flavoprotein FixB YP_002396130.1 44821 D 585397 CDS YP_002396131.1 218687919 7144190 45813..47099 1 NC_011745.1 FAD/NAD(P)-binding domain; possibly part of an electron transfer system required for anaerobic carnitine reduction; putative oxidoreductase FixC 47099 fixC 7144190 fixC Escherichia coli ED1a putative oxidoreductase FixC YP_002396131.1 45813 D 585397 CDS YP_002396132.1 218687920 7144191 47096..47383 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96066354, 12081978; Product type pc : putative carrier; putative 4Fe-4S ferredoxin 47383 fixX 7144191 fixX Escherichia coli ED1a putative 4Fe-4S ferredoxin YP_002396132.1 47096 D 585397 CDS YP_002396133.1 218687921 7144192 47442..48773 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 48773 yaaU 7144192 yaaU Escherichia coli ED1a putative transporter YP_002396133.1 47442 D 585397 CDS YP_002396134.1 218687922 7143357 48881..49411 1 NC_011745.1 Required for full activity of KefC, a potassium-proton antiporter; glutathione-regulated potassium-efflux system ancillary protein KefF 49411 kefF 7143357 kefF Escherichia coli ED1a glutathione-regulated potassium-efflux system ancillary protein KefF YP_002396134.1 48881 D 585397 CDS YP_002396135.1 218687923 7142508 49404..51266 1 NC_011745.1 transport system that facilitates potassium-efflux; glutathione-regulated potassium-efflux system protein KefC 51266 kefC 7142508 kefC Escherichia coli ED1a glutathione-regulated potassium-efflux system protein KefC YP_002396135.1 49404 D 585397 CDS YP_002396136.1 218687924 7142507 51458..51937 1 NC_011745.1 catalyzes the reduction of dihydrofolate to tetrahydrofolate; dihydrofolate reductase 51937 folA 7142507 folA Escherichia coli ED1a dihydrofolate reductase YP_002396136.1 51458 D 585397 CDS YP_002396137.1 218687925 7142155 52023..52256 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative antitoxin of gyrase inhibiting toxin-antitoxin system 52256 7142155 ECED1_0048 Escherichia coli ED1a putative antitoxin of gyrase inhibiting toxin-antitoxin system YP_002396137.1 52023 D 585397 CDS YP_002396138.1 218687926 7142833 52259..52573 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative toxin of gyrase inhibiting toxin-antitoxin system 52573 7142833 ECED1_0049 Escherichia coli ED1a putative toxin of gyrase inhibiting toxin-antitoxin system YP_002396138.1 52259 D 585397 CDS YP_002396139.1 218687927 7142834 complement(52570..53418) 1 NC_011745.1 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; diadenosine tetraphosphatase 53418 apaH 7142834 apaH Escherichia coli ED1a diadenosine tetraphosphatase YP_002396139.1 52570 R 585397 CDS YP_002396140.1 218687928 7142589 complement(53425..53802) 1 NC_011745.1 protein associated with Co2+ and Mg2+ efflux; ApaG protein 53802 apaG 7142589 apaG Escherichia coli ED1a ApaG protein YP_002396140.1 53425 R 585397 CDS YP_002396141.1 218687929 7142588 complement(53805..54626) 1 NC_011745.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 54626 ksgA 7142588 ksgA Escherichia coli ED1a dimethyladenosine transferase YP_002396141.1 53805 R 585397 CDS YP_002396142.1 218687930 7142522 complement(54623..55612) 1 NC_011745.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate); 4-hydroxythreonine-4-phosphate dehydrogenase 55612 pdxA 7142522 pdxA Escherichia coli ED1a 4-hydroxythreonine-4-phosphate dehydrogenase YP_002396142.1 54623 R 585397 CDS YP_002396143.1 218687931 7144052 complement(55612..56898) 1 NC_011745.1 Chaperone involved in the folding of extracytoplasmic proteins, especially OmpA, OmpF and LamB; peptidyl-prolyl cis-trans isomerase SurA 56898 surA 7144052 surA Escherichia coli ED1a peptidyl-prolyl cis-trans isomerase SurA YP_002396143.1 55612 R 585397 CDS YP_002396144.1 218687932 7141500 complement(56951..59305) 1 NC_011745.1 determines N-hexane tolerance and is involved in outer membrane permeability; organic solvent tolerance protein 59305 imp 7141500 imp Escherichia coli ED1a organic solvent tolerance protein YP_002396144.1 56951 R 585397 CDS YP_002396145.1 218687933 7141107 59560..60375 1 NC_011745.1 functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system; Dna-J like membrane chaperone protein 60375 djlA 7141107 djlA Escherichia coli ED1a Dna-J like membrane chaperone protein YP_002396145.1 59560 D 585397 CDS YP_002396146.1 218687934 7140493 complement(60493..61152) 1 NC_011745.1 catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs; 23S rRNA/tRNA pseudouridine synthase A 61152 rluA 7140493 rluA Escherichia coli ED1a 23S rRNA/tRNA pseudouridine synthase A YP_002396146.1 60493 R 585397 CDS YP_002396147.1 218687935 7141424 complement(61164..64070) 1 NC_011745.1 transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA; ATP-dependent helicase HepA 64070 hepA 7141424 hepA Escherichia coli ED1a ATP-dependent helicase HepA YP_002396147.1 61164 R 585397 CDS YP_002396148.1 218687936 7139877 complement(64234..66585) 1 NC_011745.1 Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C; DNA polymerase II 66585 polB 7139877 polB Escherichia coli ED1a DNA polymerase II YP_002396148.1 64234 R 585397 CDS YP_002396149.1 218687937 7139082 complement(66660..67355) 1 NC_011745.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 67355 araD 7139082 araD Escherichia coli ED1a L-ribulose-5-phosphate 4-epimerase YP_002396149.1 66660 R 585397 CDS YP_002396150.1 218687938 7142599 complement(67640..69142) 1 NC_011745.1 catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism; L-arabinose isomerase 69142 araA 7142599 araA Escherichia coli ED1a L-arabinose isomerase YP_002396150.1 67640 R 585397 CDS YP_002396151.1 218687939 7142596 complement(69153..70853) 1 NC_011745.1 catalyzes the phosphorylation of ribulose to ribulose 5-phosphate; ribulokinase 70853 araB 7142596 araB Escherichia coli ED1a ribulokinase YP_002396151.1 69153 R 585397 CDS YP_002396152.1 218687940 7142597 71141..72037 1 NC_011745.1 positive and negative regulator; regulates the araBAD and araFGH operons and other genes involved in the transport and catabolism of L-arabinose; DNA-binding transcriptional regulator AraC 72037 araC 7142597 araC Escherichia coli ED1a DNA-binding transcriptional regulator AraC YP_002396152.1 71141 D 585397 CDS YP_002396153.1 218687941 7142598 72549..73400 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 73400 7142598 ECED1_0064 Escherichia coli ED1a hypothetical protein YP_002396153.1 72549 D 585397 CDS YP_002396154.1 218687942 7142835 73407..73829 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 73829 7142835 ECED1_0065 Escherichia coli ED1a hypothetical protein YP_002396154.1 73407 D 585397 CDS YP_002396155.1 218687943 7142836 73984..74748 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 74748 yabI 7142836 yabI Escherichia coli ED1a hypothetical protein YP_002396155.1 73984 D 585397 CDS YP_002396156.1 218687944 7143360 complement(74862..75560) 1 NC_011745.1 with TbpA and ThiP is part of the thiamine and TPP transport system; thiamine transporter ATP-binding subunit 75560 thiQ 7143360 thiQ Escherichia coli ED1a thiamine transporter ATP-binding subunit YP_002396156.1 74862 R 585397 CDS YP_002396157.1 218687945 7141549 complement(75544..77154) 1 NC_011745.1 permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine; thiamine transporter membrane protein 77154 thiP 7141549 thiP Escherichia coli ED1a thiamine transporter membrane protein YP_002396157.1 75544 R 585397 CDS YP_002396158.1 218687946 7141548 complement(77130..78113) 1 NC_011745.1 part of the thiamine and TPP transport system tbpA-thiPQ; thiamine transporter substrate binding subunit 78113 tbpA 7141548 tbpA Escherichia coli ED1a thiamine transporter substrate binding subunit YP_002396158.1 77130 R 585397 CDS YP_002396159.1 218687947 7140752 complement(78277..79932) 1 NC_011745.1 activates sgrS under glucose-phosphate stress conditions; transcriptional regulator SgrR 79932 sgrR 7140752 sgrR Escherichia coli ED1a transcriptional regulator SgrR YP_002396159.1 78277 R 585397 CDS YP_002396160.1 218687948 7143793 complement(80260..80865) 1 NC_011745.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit 80865 leuD 7143793 leuD Escherichia coli ED1a isopropylmalate isomerase small subunit YP_002396160.1 80260 R 585397 CDS YP_002396161.1 218687949 7141878 complement(80876..82276) 1 NC_011745.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit 82276 leuC 7141878 leuC Escherichia coli ED1a isopropylmalate isomerase large subunit YP_002396161.1 80876 R 585397 CDS YP_002396162.1 218687950 7141877 complement(82279..83370) 1 NC_011745.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase 83370 leuB 7141877 leuB Escherichia coli ED1a 3-isopropylmalate dehydrogenase YP_002396162.1 82279 R 585397 CDS YP_002396163.1 218687951 7141876 complement(83370..84941) 1 NC_011745.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis; 2-isopropylmalate synthase 84941 leuA 7141876 leuA Escherichia coli ED1a 2-isopropylmalate synthase YP_002396163.1 83370 R 585397 CDS YP_002396164.1 218687952 7141875 complement(85034..85120) 1 NC_011745.1 involved in attenuation control of the leuABCD operon in leucine biosynthesis; leu operon leader peptide 85120 leuL 7141875 leuL Escherichia coli ED1a leu operon leader peptide YP_002396164.1 85034 R 585397 CDS YP_002396165.1 218687953 7141880 86446..86721 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 86721 insA 7141880 insA Escherichia coli ED1a IS1 repressor protein InsA YP_002396165.1 86446 D 585397 CDS YP_002396166.1 218687954 7141112 86640..87143 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 87143 insB 7141112 insB Escherichia coli ED1a IS1 transposase InsAB' YP_002396166.1 86640 D 585397 CDS YP_002396167.1 218687955 7141881 87817..89541 1 NC_011745.1 catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; acetolactate synthase 3 catalytic subunit 89541 ilvI 7141881 ilvI Escherichia coli ED1a acetolactate synthase 3 catalytic subunit YP_002396167.1 87817 D 585397 CDS YP_002396168.1 218687956 7140242 89544..90035 1 NC_011745.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 90035 ilvH 7140242 ilvH Escherichia coli ED1a acetolactate synthase 3 regulatory subunit YP_002396168.1 89544 D 585397 CDS YP_002396169.1 218687957 7140241 90215..91219 1 NC_011745.1 binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism; DNA-binding transcriptional regulator FruR 91219 fruR 7140241 fruR Escherichia coli ED1a DNA-binding transcriptional regulator FruR YP_002396169.1 90215 D 585397 CDS YP_002396170.1 218687958 7142180 91821..92279 1 NC_011745.1 MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 92279 mraZ 7142180 mraZ Escherichia coli ED1a cell division protein MraZ YP_002396170.1 91821 D 585397 CDS YP_002396171.1 218687959 7139021 92281..93222 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20042184, 10493123, 2187182, 6350821; Product type e : enzyme; S-adenosyl-methyltransferase MraW 93222 mraW 7139021 mraW Escherichia coli ED1a S-adenosyl-methyltransferase MraW YP_002396171.1 92281 D 585397 CDS YP_002396172.1 218687960 7139019 93219..93584 1 NC_011745.1 membrane bound cell division protein at septum containing leucine zipper motif; cell division protein FtsL 93584 ftsL 7139019 ftsL Escherichia coli ED1a cell division protein FtsL YP_002396172.1 93219 D 585397 CDS YP_002396173.1 218687961 7143117 93600..95366 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91072213, 92202178, 94095121, 9603865, 9614966, 1332942, 1447153, 2198024, 2677607, 2681146, 3049550, 3911028, 6350821; Product type e : enzyme; transpeptidase involved in septal peptidoglycan synthesis (penicillin-binding protein 3) 95366 ftsI 7143117 ftsI Escherichia coli ED1a transpeptidase involved in septal peptidoglycan synthesis (penicillin-binding protein 3) YP_002396173.1 93600 D 585397 CDS YP_002396174.1 218687962 7142192 95353..96840 1 NC_011745.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 96840 murE 7142192 murE Escherichia coli ED1a UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase YP_002396174.1 95353 D 585397 CDS YP_002396175.1 218687963 7139049 96837..98195 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88273095, 90248455, 91310568, 97128642, 11090285, 2668880, 9166795; Product type e : enzyme; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase 98195 murF 7139049 murF Escherichia coli ED1a UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase YP_002396175.1 96837 D 585397 CDS YP_002396176.1 218687964 7139050 98189..99271 1 NC_011745.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 99271 mraY 7139050 mraY Escherichia coli ED1a phospho-N-acetylmuramoyl-pentapeptide- transferase YP_002396176.1 98189 D 585397 CDS YP_002396177.1 218687965 7139020 99274..100590 1 NC_011745.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 100590 murD 7139020 murD Escherichia coli ED1a UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase YP_002396177.1 99274 D 585397 CDS YP_002396178.1 218687966 7139048 100590..101834 1 NC_011745.1 integral membrane protein involved in stabilizing FstZ ring during cell division; cell division protein FtsW 101834 ftsW 7139048 ftsW Escherichia coli ED1a cell division protein FtsW YP_002396178.1 100590 D 585397 CDS YP_002396179.1 218687967 7143120 101831..102898 1 NC_011745.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 102898 murG 7143120 murG Escherichia coli ED1a undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase YP_002396179.1 101831 D 585397 CDS YP_002396180.1 218687968 7139051 102952..104427 1 NC_011745.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 104427 murC 7139051 murC Escherichia coli ED1a UDP-N-acetylmuramate--L-alanine ligase YP_002396180.1 102952 D 585397 CDS YP_002396181.1 218687969 7139047 104420..105340 1 NC_011745.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanine--D-alanine ligase 105340 ddl 7139047 ddl Escherichia coli ED1a D-alanine--D-alanine ligase YP_002396181.1 104420 D 585397 CDS YP_002396182.1 218687970 7143081 105342..106172 1 NC_011745.1 involved in septum formation; cell division protein FtsQ 106172 ftsQ 7143081 ftsQ Escherichia coli ED1a cell division protein FtsQ YP_002396182.1 105342 D 585397 CDS YP_002396183.1 218687971 7143119 106169..107431 1 NC_011745.1 ATP-binding involved in recruitment of FtsK to Z ring; essential cell division protein; colocalizes with FtsZ through direct interaction to the septal ring structure; structurally similar to eukaryotic actin; binds directly to the cell membrane; cell division protein FtsA 107431 ftsA 7143119 ftsA Escherichia coli ED1a cell division protein FtsA YP_002396183.1 106169 D 585397 CDS YP_002396184.1 218687972 7142188 107492..108643 1 NC_011745.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 108643 ftsZ 7142188 ftsZ Escherichia coli ED1a cell division protein FtsZ YP_002396184.1 107492 D 585397 CDS YP_002396185.1 218687973 7143123 108744..109661 1 NC_011745.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 109661 lpxC 7143123 lpxC Escherichia coli ED1a UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase YP_002396185.1 108744 D 585397 CDS YP_002396186.1 218687974 7141919 109892..110404 1 NC_011745.1 secM translational pause allows for the initiation of secA translation; SecA regulator SecM 110404 secM 7141919 secM Escherichia coli ED1a SecA regulator SecM YP_002396186.1 109892 D 585397 CDS YP_002396187.1 218687975 7141391 110466..113171 1 NC_011745.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 113171 secA 7141391 secA Escherichia coli ED1a preprotein translocase subunit SecA YP_002396187.1 110466 D 585397 CDS YP_002396188.1 218687976 7141385 113231..113629 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10218109, 89264540, 90136514, 91225007, 97444511, 1309939, 2841285, 3033442, 3288626, 7578113, 9063868; Product type e : enzyme; nucleoside triphosphate pyrophosphohydrolase 113629 mutT 7141385 mutT Escherichia coli ED1a nucleoside triphosphate pyrophosphohydrolase YP_002396188.1 113231 D 585397 CDS YP_002396189.1 218687977 7139058 complement(114040..114783) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 114783 yacF 7139058 yacF Escherichia coli ED1a hypothetical protein YP_002396189.1 114040 R 585397 CDS YP_002396190.1 218687978 7143362 complement(114783..115403) 1 NC_011745.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 115403 coaE 7143362 coaE Escherichia coli ED1a dephospho-CoA kinase YP_002396190.1 114783 R 585397 CDS YP_002396191.1 218687979 7142031 115628..116671 1 NC_011745.1 catalyzes the NADPH-dependent deamination of GMP to inosine monophosphate; guanosine 5'-monophosphate oxidoreductase 116671 guaC 7142031 guaC Escherichia coli ED1a guanosine 5'-monophosphate oxidoreductase YP_002396191.1 115628 D 585397 CDS YP_002396192.1 218687980 7139845 complement(116706..117908) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96099298, 2904262, 7959070; Product type s : structure; type IV pilin biogenesis protein 117908 hofC 7139845 hofC Escherichia coli ED1a type IV pilin biogenesis protein YP_002396192.1 116706 R 585397 CDS YP_002396193.1 218687981 7139907 complement(117898..119283) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96099298, 7959070; Product type pt : putative transporter; hypothetical protein 119283 hofB 7139907 hofB Escherichia coli ED1a hypothetical protein YP_002396193.1 117898 R 585397 CDS YP_002396194.1 218687982 7139906 complement(119293..119733) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20100782, 20271862, 96099298, 7959070; Product type ps : putative structure; putative major pilin subunit 119733 ppdD 7139906 ppdD Escherichia coli ED1a putative major pilin subunit YP_002396194.1 119293 R 585397 CDS YP_002396195.1 218687983 7139100 complement(119937..120830) 1 NC_011745.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; quinolinate phosphoribosyltransferase 120830 nadC 7139100 nadC Escherichia coli ED1a quinolinate phosphoribosyltransferase YP_002396195.1 119937 R 585397 CDS YP_002396196.1 218687984 7140332 120918..121469 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90113890, 95047240, 2607970, 7959070; Product type e : enzyme; N-acetyl-anhydromuranmyl-L-alanine amidase 121469 ampD 7140332 ampD Escherichia coli ED1a N-acetyl-anhydromuranmyl-L-alanine amidase YP_002396196.1 120918 D 585397 CDS YP_002396197.1 218687985 7143707 121466..122320 1 NC_011745.1 involved in regulation of beta-lactamase; putative signaling protein; regulatory protein AmpE 122320 ampE 7143707 ampE Escherichia coli ED1a regulatory protein AmpE YP_002396197.1 121466 D 585397 CDS YP_002396198.1 218687986 7143708 complement(122363..123733) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1104763, 90174991, 9150230; Product type t : transporter; aromatic amino acid transporter 123733 aroP 7143708 aroP Escherichia coli ED1a aromatic amino acid transporter YP_002396198.1 122363 R 585397 CDS YP_002396199.1 218687987 7142634 124261..126042 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10702359; hypothetical protein 126042 7142634 ECED1_0111 Escherichia coli ED1a hypothetical protein YP_002396199.1 124261 D 585397 CDS YP_002396200.1 218687988 7142837 126045..126329 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative Colicin E7 immunity protein 126329 7142837 ECED1_0112 Escherichia coli ED1a putative Colicin E7 immunity protein YP_002396200.1 126045 D 585397 CDS YP_002396201.1 218687989 7142839 126737..127027 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative Colicin E7 immunity protein 127027 7142839 ECED1_0114 Escherichia coli ED1a putative Colicin E7 immunity protein YP_002396201.1 126737 D 585397 CDS YP_002396202.1 218687990 7142841 127430..127726 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative Colicin E7 immunity protein 127726 7142841 ECED1_0116 Escherichia coli ED1a putative Colicin E7 immunity protein YP_002396202.1 127430 D 585397 CDS YP_002396203.1 218687991 7142842 128182..128946 1 NC_011745.1 activates lctPRD operon; autoregulates itself through repression of pdhR-aceEF-lpdA operon; regulates pyruvate dehydrogenase complex; transcriptional regulator PdhR 128946 pdhR 7142842 pdhR Escherichia coli ED1a transcriptional regulator PdhR YP_002396203.1 128182 D 585397 CDS YP_002396204.1 218687992 7140759 129107..131770 1 NC_011745.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 131770 aceE 7140759 aceE Escherichia coli ED1a pyruvate dehydrogenase subunit E1 YP_002396204.1 129107 D 585397 CDS YP_002396205.1 218687993 7143638 131785..133677 1 NC_011745.1 E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains; dihydrolipoamide acetyltransferase 133677 aceF 7143638 aceF Escherichia coli ED1a dihydrolipoamide acetyltransferase YP_002396205.1 131785 D 585397 CDS YP_002396206.1 218687994 7143639 133885..135309 1 NC_011745.1 E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 135309 lpd 7143639 lpd Escherichia coli ED1a dihydrolipoamide dehydrogenase YP_002396206.1 133885 D 585397 CDS YP_002396207.1 218687995 7141908 complement(135551..137308) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 137308 yacH 7141908 yacH Escherichia coli ED1a hypothetical protein YP_002396207.1 135551 R 585397 CDS YP_002396208.1 218687996 7143363 137663..140260 1 NC_011745.1 catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate; bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase 140260 acnB 7143363 acnB Escherichia coli ED1a bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase YP_002396208.1 137663 D 585397 CDS YP_002396209.1 218687997 7143644 140435..140797 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2666401, 7567469; hypothetical protein 140797 yacL 7143644 yacL Escherichia coli ED1a hypothetical protein YP_002396209.1 140435 D 585397 CDS YP_002396210.1 218687998 7143364 complement(140835..141629) 1 NC_011745.1 S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine; S-adenosylmethionine decarboxylase 141629 speD 7143364 speD Escherichia coli ED1a S-adenosylmethionine decarboxylase YP_002396210.1 140835 R 585397 CDS YP_002396211.1 218687999 7143826 complement(141645..142511) 1 NC_011745.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 142511 speE 7143826 speE Escherichia coli ED1a spermidine synthase YP_002396211.1 141645 R 585397 CDS YP_002396212.1 218688000 7143827 complement(142617..143135) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2666401; hypothetical protein 143135 yacC 7143827 yacC Escherichia coli ED1a hypothetical protein YP_002396212.1 142617 R 585397 CDS YP_002396213.1 218688001 7143361 143130..144680 1 NC_011745.1 laccase; copper-stimulated phenoloxidase and ferroxidase which may be involved in copper detoxification; multicopper oxidase 144680 cueO 7143361 cueO Escherichia coli ED1a multicopper oxidase YP_002396213.1 143130 D 585397 CDS YP_002396214.1 218688002 7142081 complement(144727..147117) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10359647, 11604400, 14612441, 91035240, 93123180, 93286127; Product type e : enzyme; glucose dehydrogenase 147117 gcd 7142081 gcd Escherichia coli ED1a glucose dehydrogenase YP_002396214.1 144727 R 585397 CDS YP_002396215.1 218688003 7143164 147323..147859 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 13808016, 339828, 6787390, 6801015, 12070315; Product type e : enzyme; hypoxanthine phosphoribosyltransferase 147859 hpt 7143164 hpt Escherichia coli ED1a hypoxanthine phosphoribosyltransferase YP_002396215.1 147323 D 585397 CDS YP_002396216.1 218688004 7139915 complement(147900..148562) 1 NC_011745.1 catalyzes the interconversion of bicarbonate and carbon dioxide; carbonic anhydrase 148562 can 7139915 can Escherichia coli ED1a carbonic anhydrase YP_002396216.1 147900 R 585397 CDS YP_002396217.1 218688005 7139305 148671..149597 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATP-binding protein 149597 yadG 7139305 yadG Escherichia coli ED1a putative ABC transporter ATP-binding protein YP_002396217.1 148671 D 585397 CDS YP_002396218.1 218688006 7143368 149594..150364 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10474187; Product type pt : putative transporter; putative ABC transporter membrane protein 150364 yadH 7143368 yadH Escherichia coli ED1a putative ABC transporter membrane protein YP_002396218.1 149594 D 585397 CDS YP_002396219.1 218688007 7143369 150469..150909 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative PTS Enzyme IIA 150909 yadI 7143369 yadI Escherichia coli ED1a putative PTS Enzyme IIA YP_002396219.1 150469 D 585397 CDS YP_002396220.1 218688008 7143370 150973..152202 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative exported polysaccharide deacetylase 152202 yadE 7143370 yadE Escherichia coli ED1a putative exported polysaccharide deacetylase YP_002396220.1 150973 D 585397 CDS YP_002396221.1 218688009 7143367 complement(152206..152586) 1 NC_011745.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase 152586 panD 7143367 panD Escherichia coli ED1a aspartate alpha-decarboxylase YP_002396221.1 152206 R 585397 CDS YP_002396222.1 218688010 7144041 152860..153840 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11319082; Product type pe : putative enzyme; putative transposase 153840 yadD 7144041 yadD Escherichia coli ED1a putative transposase YP_002396222.1 152860 D 585397 CDS YP_002396223.1 218688011 7143366 complement(153922..154773) 1 NC_011745.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase 154773 panC 7143366 panC Escherichia coli ED1a pantoate--beta-alanine ligase YP_002396223.1 153922 R 585397 CDS YP_002396224.1 218688012 7144040 complement(154785..155579) 1 NC_011745.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase 155579 panB 7144040 panB Escherichia coli ED1a 3-methyl-2-oxobutanoate hydroxymethyltransferase YP_002396224.1 154785 R 585397 CDS YP_002396225.1 218688013 7142843 complement(157002..157598) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type ps : putative structure; protein yadK, putative fimbrial-like adhesin 157598 7142843 ECED1_0141 Escherichia coli ED1a protein yadK, putative fimbrial-like adhesin YP_002396225.1 157002 R 585397 CDS YP_002396226.1 218688014 7142844 complement(157625..158239) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin protein YadL 158239 7142844 ECED1_0142 Escherichia coli ED1a putative fimbrial-like adhesin protein YadL YP_002396226.1 157625 R 585397 CDS YP_002396227.1 218688015 7142845 complement(158245..158811) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin protein YadM 158811 7142845 ECED1_0143 Escherichia coli ED1a putative fimbrial-like adhesin protein YadM YP_002396227.1 158245 R 585397 CDS YP_002396228.1 218688016 7142846 complement(158828..161416) 1 NC_011745.1 similar to the fimbrial usher protein PapC; putative outer membrane usher protein 161416 htrE 7142846 htrE Escherichia coli ED1a putative outer membrane usher protein YP_002396228.1 158828 R 585397 CDS YP_002396229.1 218688017 7140175 complement(161451..162191) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 93352405, 8102362, 15561151; Product type f : factor; putative chaperone protein EcpD 162191 ecpD 7140175 ecpD Escherichia coli ED1a putative chaperone protein EcpD YP_002396229.1 161451 R 585397 CDS YP_002396230.1 218688018 7139771 complement(162300..162914) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin exported protein 162914 yadN 7139771 yadN Escherichia coli ED1a putative fimbrial-like adhesin exported protein YP_002396230.1 162300 R 585397 CDS YP_002396231.1 218688019 7143371 complement(163254..163733) 1 NC_011745.1 catalyzes the formation of 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine and ATP; 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase 163733 folK 7143371 folK Escherichia coli ED1a 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase YP_002396231.1 163254 R 585397 CDS YP_002396232.1 218688020 7142160 complement(163730..165148) 1 NC_011745.1 Polymerase that creates the 3' poly(A) tail found in some mRNA's; poly(A) polymerase I 165148 pcnB 7142160 pcnB Escherichia coli ED1a poly(A) polymerase I YP_002396232.1 163730 R 585397 CDS YP_002396233.1 218688021 7144050 complement(165187..166113) 1 NC_011745.1 this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu; glutamyl-Q tRNA(Asp) synthetase 166113 yadB 7144050 yadB Escherichia coli ED1a glutamyl-Q tRNA(Asp) synthetase YP_002396233.1 165187 R 585397 CDS YP_002396234.1 218688022 7143365 complement(166150..166605) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15294157, 90202727, 2013578, 9298646, 9600841; Product type r : regulator; RNA polymerase-binding transcription factor 166605 dksA 7143365 dksA Escherichia coli ED1a RNA polymerase-binding transcription factor YP_002396234.1 166150 R 585397 CDS YP_002396235.1 218688023 7140496 complement(166783..167487) 1 NC_011745.1 Regulatory factor involved in maltose metabolism; sugar fermentation stimulation protein A 167487 sfsA 7140496 sfsA Escherichia coli ED1a sugar fermentation stimulation protein A YP_002396235.1 166783 R 585397 CDS YP_002396236.1 218688024 7141404 complement(167502..168032) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 97094878; Product type e : enzyme; 2'-5' RNA ligase 168032 ligT 7141404 ligT Escherichia coli ED1a 2'-5' RNA ligase YP_002396236.1 167502 R 585397 CDS YP_002396237.1 218688025 7141887 168106..170535 1 NC_011745.1 similar in sequence to the ATP-dependent RNA helicase HrpA; ATP-dependent RNA helicase HrpB 170535 hrpB 7141887 hrpB Escherichia coli ED1a ATP-dependent RNA helicase HrpB YP_002396237.1 168106 D 585397 CDS YP_002396238.1 218688026 7139917 170629..173163 1 NC_011745.1 bifunctional periplasmic enzyme; contains transglycosylase and transpeptidase activity; major enzyme for peptidoglycan biosynthesis in Escherichia coli; transmembrane protein; forms dimers; three variants, one of which may be a degradation product, while the other appears to result from an alternative initiation site, are found within the cell; penicillin-binding protein 1b 173163 mrcB 7139917 mrcB Escherichia coli ED1a penicillin-binding protein 1b YP_002396238.1 170629 D 585397 CDS YP_002396239.1 218688027 7139023 173383..175641 1 NC_011745.1 involved with the transport of ferrichrome across the outer membrane; binds the ferrichrome-iron ligand and interacts with the TonB protein; ferrichrome outer membrane transporter 175641 fhuA 7139023 fhuA Escherichia coli ED1a ferrichrome outer membrane transporter YP_002396239.1 173383 D 585397 CDS YP_002396240.1 218688028 7144169 175692..176489 1 NC_011745.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; iron-hydroxamate transporter ATP-binding subunit 176489 fhuC 7144169 fhuC Escherichia coli ED1a iron-hydroxamate transporter ATP-binding subunit YP_002396240.1 175692 D 585397 CDS YP_002396241.1 218688029 7144171 176489..177379 1 NC_011745.1 Part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; binds to all hydroxamate siderophores; iron-hydroxamate transporter substrate-binding subunit 177379 fhuD 7144171 fhuD Escherichia coli ED1a iron-hydroxamate transporter substrate-binding subunit YP_002396241.1 176489 D 585397 CDS YP_002396242.1 218688030 7144172 177376..179358 1 NC_011745.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome; iron-hydroxamate transporter permease subunit 179358 fhuB 7144172 fhuB Escherichia coli ED1a iron-hydroxamate transporter permease subunit YP_002396242.1 177376 D 585397 CDS YP_002396243.1 218688031 7144170 complement(179393..180673) 1 NC_011745.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase 180673 hemL 7144170 hemL Escherichia coli ED1a glutamate-1-semialdehyde aminotransferase YP_002396243.1 179393 R 585397 CDS YP_002396244.1 218688032 7139873 180898..182319 1 NC_011745.1 Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation; chloride channel protein 182319 clcA 7139873 clcA Escherichia coli ED1a chloride channel protein YP_002396244.1 180898 D 585397 CDS YP_002396245.1 218688033 7139368 182401..182745 1 NC_011745.1 essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors; iron-sulfur cluster insertion protein ErpA 182745 yadR 7139368 yadR Escherichia coli ED1a iron-sulfur cluster insertion protein ErpA YP_002396245.1 182401 D 585397 CDS YP_002396246.1 218688034 7143372 complement(182792..183415) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 183415 yadS 7143372 yadS Escherichia coli ED1a hypothetical protein YP_002396246.1 182792 R 585397 CDS YP_002396247.1 218688035 7143373 complement(183453..184253) 1 NC_011745.1 solute binding component of the vitamin B12 transport system BtuCDF; vitamin B12-transporter protein BtuF 184253 btuF 7143373 btuF Escherichia coli ED1a vitamin B12-transporter protein BtuF YP_002396247.1 183453 R 585397 CDS YP_002396248.1 218688036 7140468 complement(184246..184944) 1 NC_011745.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 184944 pfs 7140468 pfs Escherichia coli ED1a 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase YP_002396248.1 184246 R 585397 CDS YP_002396249.1 218688037 7144073 185028..186545 1 NC_011745.1 forms a homotetramer; requires magnesium for activity; catalyzes the hydrolysis of dGTP to form deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase 186545 dgt 7144073 dgt Escherichia coli ED1a deoxyguanosinetriphosphate triphosphohydrolase YP_002396249.1 185028 D 585397 CDS YP_002396250.1 218688038 7143109 186675..188099 1 NC_011745.1 protease Do; required at high temperature; degrades damaged proteins; serine endoprotease 188099 degP 7143109 degP Escherichia coli ED1a serine endoprotease YP_002396250.1 186675 D 585397 CDS YP_002396251.1 218688039 7143086 188254..189411 1 NC_011745.1 regulates the expression of the operons for the enzymes involved in galactarate, glucarate and glycerate utilization; carbohydrate diacid transcriptional activator CdaR 189411 cdaR 7143086 cdaR Escherichia coli ED1a carbohydrate diacid transcriptional activator CdaR YP_002396251.1 188254 D 585397 CDS YP_002396252.1 218688040 7139323 complement(189465..189851) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 189851 yaeH 7139323 yaeH Escherichia coli ED1a hypothetical protein YP_002396252.1 189465 R 585397 CDS YP_002396253.1 218688041 7143376 complement(190163..190987) 1 NC_011745.1 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 190987 dapD 7143376 dapD Escherichia coli ED1a 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase YP_002396253.1 190163 R 585397 CDS YP_002396254.1 218688042 7143064 complement(191018..193690) 1 NC_011745.1 catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein; PII uridylyl-transferase 193690 glnD 7143064 glnD Escherichia coli ED1a PII uridylyl-transferase YP_002396254.1 191018 R 585397 CDS YP_002396255.1 218688043 7142954 complement(193752..194546) 1 NC_011745.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase 194546 map 7142954 map Escherichia coli ED1a methionine aminopeptidase YP_002396255.1 193752 R 585397 CDS YP_002396256.1 218688044 7140762 194914..195639 1 NC_011745.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 195639 rpsB 7140762 rpsB Escherichia coli ED1a 30S ribosomal protein S2 YP_002396256.1 194914 D 585397 CDS YP_002396257.1 218688045 7140085 195774..196625 1 NC_011745.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 196625 tsf 7140085 tsf Escherichia coli ED1a elongation factor Ts YP_002396257.1 195774 D 585397 CDS YP_002396258.1 218688046 7140834 196772..197497 1 NC_011745.1 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 197497 pyrH 7140834 pyrH Escherichia coli ED1a uridylate kinase YP_002396258.1 196772 D 585397 CDS YP_002396259.1 218688047 7141237 197647..198204 1 NC_011745.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 198204 frr 7141237 frr Escherichia coli ED1a ribosome recycling factor YP_002396259.1 197647 D 585397 CDS YP_002396260.1 218688048 7142175 198296..199492 1 NC_011745.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 199492 dxr 7142175 dxr Escherichia coli ED1a 1-deoxy-D-xylulose 5-phosphate reductoisomerase YP_002396260.1 198296 D 585397 CDS YP_002396261.1 218688049 7139758 199678..200439 1 NC_011745.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 200439 ispU 7139758 ispU Escherichia coli ED1a undecaprenyl pyrophosphate synthase YP_002396261.1 199678 D 585397 CDS YP_002396262.1 218688050 7142469 200452..201309 1 NC_011745.1 catalyzes the synthesis of CDP-diglyceride from CTP and phosphatidate; CDP-diglyceride synthase 201309 cdsA 7142469 cdsA Escherichia coli ED1a CDP-diglyceride synthase YP_002396262.1 200452 D 585397 CDS YP_002396263.1 218688051 7139326 201321..202673 1 NC_011745.1 catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response; zinc metallopeptidase RseP 202673 yaeL 7139326 yaeL Escherichia coli ED1a zinc metallopeptidase RseP YP_002396263.1 201321 D 585397 CDS YP_002396264.1 218688052 7143378 202703..205135 1 NC_011745.1 part of a complex with YfgL, YfiO, and NlpB involved in outer membrane protein biosynthesis; involved in the assembly of outer membrane proteins; outer membrane protein assembly factor YaeT 205135 yaeT 7143378 yaeT Escherichia coli ED1a outer membrane protein assembly factor YaeT YP_002396264.1 202703 D 585397 CDS YP_002396265.1 218688053 7143382 205257..205742 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15101556, 90201355, 97032152, 99386928, 1987124, 2843433, 9298646, 2167239; Product type f : factor; periplasmic chaperone 205742 hlpA 7143382 hlpA Escherichia coli ED1a periplasmic chaperone YP_002396265.1 205257 D 585397 CDS YP_002396266.1 218688054 7139901 205746..206771 1 NC_011745.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 206771 lpxD 7139901 lpxD Escherichia coli ED1a UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase YP_002396266.1 205746 D 585397 CDS YP_002396267.1 218688055 7141920 206876..207331 1 NC_011745.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 207331 fabZ 7141920 fabZ Escherichia coli ED1a (3R)-hydroxymyristoyl-ACP dehydratase YP_002396267.1 206876 D 585397 CDS YP_002396268.1 218688056 7144123 207335..208123 1 NC_011745.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 208123 lpxA 7144123 lpxA Escherichia coli ED1a UDP-N-acetylglucosamine acyltransferase YP_002396268.1 207335 D 585397 CDS YP_002396269.1 218688057 7141917 208123..209271 1 NC_011745.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; lipid-A-disaccharide synthase 209271 lpxB 7141917 lpxB Escherichia coli ED1a lipid-A-disaccharide synthase YP_002396269.1 208123 D 585397 CDS YP_002396270.1 218688058 7141918 209268..209864 1 NC_011745.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 209864 rnhB 7141918 rnhB Escherichia coli ED1a ribonuclease HII YP_002396270.1 209268 D 585397 CDS YP_002396271.1 218688059 7141438 209901..213383 1 NC_011745.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 213383 dnaE 7141438 dnaE Escherichia coli ED1a DNA polymerase III subunit alpha YP_002396271.1 209901 D 585397 CDS YP_002396272.1 218688060 7140505 213396..214355 1 NC_011745.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 214355 accA 7140505 accA Escherichia coli ED1a acetyl-CoA carboxylase carboxyltransferase subunit alpha YP_002396272.1 213396 D 585397 CDS YP_002396273.1 218688061 7143632 214453..216594 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 97480927, 98195734, 98357244, 9226257, 9723924; Product type e : enzyme; lysine decarboxylase 2 216594 ldcC 7143632 ldcC Escherichia coli ED1a lysine decarboxylase 2 YP_002396273.1 214453 D 585397 CDS YP_002396274.1 218688062 7141870 216651..217040 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 217040 yaeR 7141870 yaeR Escherichia coli ED1a hypothetical protein YP_002396274.1 216651 D 585397 CDS YP_002396275.1 218688063 7143381 217105..218418 1 NC_011745.1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU; ATP-dependent; responsible for modifying the wobble-base of the CAU anticodon of tRNAIle such that it exhibits proper recognition of the AUA codon rather than the AUG codon and is in turn properly recognized by isoleucyl-tRNA synthetase; tRNA(Ile)-lysidine synthetase 218418 tilS 7143381 tilS Escherichia coli ED1a tRNA(Ile)-lysidine synthetase YP_002396275.1 217105 D 585397 CDS YP_002396276.1 218688064 7141558 complement(218452..218706) 1 NC_011745.1 Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination; Rho-binding antiterminator 218706 rof 7141558 rof Escherichia coli ED1a Rho-binding antiterminator YP_002396276.1 218452 R 585397 CDS YP_002396277.1 218688065 7141445 complement(218699..218899) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 218899 yaeP 7141445 yaeP Escherichia coli ED1a hypothetical protein YP_002396277.1 218699 R 585397 CDS YP_002396278.1 218688066 7143379 219065..219610 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 219610 yaeQ 7143379 yaeQ Escherichia coli ED1a hypothetical protein YP_002396278.1 219065 D 585397 CDS YP_002396279.1 218688067 7143380 219607..220029 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; peptidyl-tRNA hydrolase domain-containing protein 220029 yaeJ 7143380 yaeJ Escherichia coli ED1a peptidyl-tRNA hydrolase domain-containing protein YP_002396279.1 219607 D 585397 CDS YP_002396280.1 218688068 7143377 220043..220753 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11830644, 95362641, 95362642; Product type lp : lipoprotein; lipoprotein involved with copper homeostasis and adhesion 220753 nlpE 7143377 nlpE Escherichia coli ED1a lipoprotein involved with copper homeostasis and adhesion YP_002396280.1 220043 D 585397 CDS YP_002396281.1 218688069 7140401 complement(220909..221733) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein 221733 yaeF 7140401 yaeF Escherichia coli ED1a hypothetical protein YP_002396281.1 220909 R 585397 CDS YP_002396282.1 218688070 7143375 complement(221786..223504) 1 NC_011745.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 223504 proS 7143375 proS Escherichia coli ED1a prolyl-tRNA synthetase YP_002396282.1 221786 R 585397 CDS YP_002396283.1 218688071 7139132 complement(223615..224322) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 224322 yaeB 7139132 yaeB Escherichia coli ED1a hypothetical protein YP_002396283.1 223615 R 585397 CDS YP_002396284.1 218688072 7143374 complement(224319..224723) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 93094132; Product type pr : putative regulator; outer membrane lipoprotein 224723 rcsF 7143374 rcsF Escherichia coli ED1a outer membrane lipoprotein YP_002396284.1 224319 R 585397 CDS YP_002396285.1 218688073 7141571 complement(224841..225656) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12169620, 12218041, 12819857, 1459951; Product type t : transporter; DL-methionine transporter substrate-binding subunit 225656 metQ 7141571 metQ Escherichia coli ED1a DL-methionine transporter substrate-binding subunit YP_002396285.1 224841 R 585397 CDS YP_002396286.1 218688074 7142261 complement(225696..226349) 1 NC_011745.1 part of the MetNIQ methionine uptake system; DL-methionine transporter permease subunit 226349 metI 7142261 metI Escherichia coli ED1a DL-methionine transporter permease subunit YP_002396286.1 225696 R 585397 CDS YP_002396287.1 218688075 7142255 complement(226342..227373) 1 NC_011745.1 part of the metNIQ transport system for methionine; DL-methionine transporter ATP-binding subunit 227373 metN 7142255 metN Escherichia coli ED1a DL-methionine transporter ATP-binding subunit YP_002396287.1 226342 R 585397 CDS YP_002396288.1 218688076 7142260 227561..228133 1 NC_011745.1 Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate; D,D-heptose 1,7-bisphosphate phosphatase 228133 gmhB 7142260 gmhB Escherichia coli ED1a D,D-heptose 1,7-bisphosphate phosphatase YP_002396288.1 227561 D 585397 CDS YP_002396289.1 218688077 7140572 233893..234696 1 NC_011745.1 catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; 2,5-diketo-D-gluconate reductase B 234696 dkgB 7140572 dkgB Escherichia coli ED1a 2,5-diketo-D-gluconate reductase B YP_002396289.1 233893 D 585397 CDS YP_002396290.1 218688078 7140495 complement(234693..235607) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 235607 yafC 7140495 yafC Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002396290.1 234693 R 585397 CDS YP_002396291.1 218688079 7143383 235848..236648 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1663890; hypothetical protein 236648 yafD 7143383 yafD Escherichia coli ED1a hypothetical protein YP_002396291.1 235848 D 585397 CDS YP_002396292.1 218688080 7143384 236726..237496 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative S-adenosyl-L-methionine-dependent methyltransferase 237496 yafE 7143384 yafE Escherichia coli ED1a putative S-adenosyl-L-methionine-dependent methyltransferase YP_002396292.1 236726 D 585397 CDS YP_002396293.1 218688081 7143385 complement(237543..238901) 1 NC_011745.1 catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; may play a role in recycling muropeptides during cell division and/or cell elongation; in Helicobacter pylori MltD is a endolytic transglycosylase involved mainly in the rearrangement of the peptidoglycan layer of the bacterial cell wall; membrane-bound lytic murein transglycosylase D 238901 mltD 7143385 mltD Escherichia coli ED1a membrane-bound lytic murein transglycosylase D YP_002396293.1 237543 R 585397 CDS YP_002396294.1 218688082 7138993 complement(238973..239728) 1 NC_011745.1 catalyzes the hydrolysis of S-D-lactoylglutathione to D-lactic acid and reduced glutathione; plays an important role in cellular detoxification using glutathione; hydroxyacylglutathione hydrolase 239728 gloB 7138993 gloB Escherichia coli ED1a hydroxyacylglutathione hydrolase YP_002396294.1 238973 R 585397 CDS YP_002396295.1 218688083 7142965 239762..240484 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative S-adenosyl-L-methionine-dependent methyltransferase 240484 yafS 7142965 yafS Escherichia coli ED1a putative S-adenosyl-L-methionine-dependent methyltransferase YP_002396295.1 239762 D 585397 CDS YP_002396296.1 218688084 7143394 complement(240481..240948) 1 NC_011745.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease H 240948 rnhA 7143394 rnhA Escherichia coli ED1a ribonuclease H YP_002396296.1 240481 R 585397 CDS YP_002396297.1 218688085 7141437 241013..241744 1 NC_011745.1 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 241744 dnaQ 7141437 dnaQ Escherichia coli ED1a DNA polymerase III subunit epsilon YP_002396297.1 241013 D 585397 CDS YP_002396298.1 218688086 7140583 242282..243067 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative aminopeptidase 243067 yafT 7140583 yafT Escherichia coli ED1a putative aminopeptidase YP_002396298.1 242282 D 585397 CDS YP_002396299.1 218688087 7143395 complement(243407..243907) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 243907 7143395 ECED1_0222 Escherichia coli ED1a hypothetical protein YP_002396299.1 243407 R 585397 CDS YP_002396300.1 218688088 7142850 complement(245272..248799) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 248799 7142850 ECED1_0227 Escherichia coli ED1a hypothetical protein YP_002396300.1 245272 R 585397 CDS YP_002396301.1 218688089 7142851 complement(248819..250327) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 250327 7142851 ECED1_0228 Escherichia coli ED1a hypothetical protein YP_002396301.1 248819 R 585397 CDS YP_002396302.1 218688090 7142852 complement(250266..251009) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 251009 7142852 ECED1_0229 Escherichia coli ED1a hypothetical protein YP_002396302.1 250266 R 585397 CDS YP_002396303.1 218688091 7142853 complement(251006..253768) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative ATP-dependent Clp proteinase Aec27 ATP-binding chain, with chaperone activity 253768 7142853 ECED1_0230 Escherichia coli ED1a putative ATP-dependent Clp proteinase Aec27 ATP-binding chain, with chaperone activity YP_002396303.1 251006 R 585397 CDS YP_002396304.1 218688092 7142854 complement(253778..254542) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 254542 7142854 ECED1_0231 Escherichia coli ED1a hypothetical protein YP_002396304.1 253778 R 585397 CDS YP_002396305.1 218688093 7142855 complement(254547..255893) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 255893 7142855 ECED1_0232 Escherichia coli ED1a hypothetical protein YP_002396305.1 254547 R 585397 CDS YP_002396306.1 218688094 7142856 complement(255896..256420) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 256420 7142856 ECED1_0233 Escherichia coli ED1a hypothetical protein YP_002396306.1 255896 R 585397 CDS YP_002396307.1 218688095 7142857 complement(256417..257709) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 257709 7142857 ECED1_0234 Escherichia coli ED1a hypothetical protein YP_002396307.1 256417 R 585397 CDS YP_002396308.1 218688096 7142858 complement(257714..258763) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 258763 7142858 ECED1_0235 Escherichia coli ED1a hypothetical protein YP_002396308.1 257714 R 585397 CDS YP_002396309.1 218688097 7142859 complement(258727..260586) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 260586 7142859 ECED1_0236 Escherichia coli ED1a hypothetical protein YP_002396309.1 258727 R 585397 CDS YP_002396310.1 218688098 7142860 complement(260574..260999) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 260999 7142860 ECED1_0237 Escherichia coli ED1a hypothetical protein YP_002396310.1 260574 R 585397 CDS YP_002396311.1 218688099 7142861 complement(261004..262488) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 262488 7142861 ECED1_0238 Escherichia coli ED1a hypothetical protein YP_002396311.1 261004 R 585397 CDS YP_002396312.1 218688100 7142862 complement(262511..263065) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 263065 7142862 ECED1_0239 Escherichia coli ED1a hypothetical protein YP_002396312.1 262511 R 585397 CDS YP_002396313.1 218688101 7142863 263724..264242 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 264242 7142863 ECED1_0240 Escherichia coli ED1a hypothetical protein YP_002396313.1 263724 D 585397 CDS YP_002396314.1 218688102 7142864 264463..266694 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative VgrG/E protein associated with Rhs elements 266694 7142864 ECED1_0241 Escherichia coli ED1a putative VgrG/E protein associated with Rhs elements YP_002396314.1 264463 D 585397 CDS YP_002396315.1 218688103 7142865 266707..267483 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 267483 7142865 ECED1_0242 Escherichia coli ED1a hypothetical protein YP_002396315.1 266707 D 585397 CDS YP_002396316.1 218688104 7142866 complement(267712..267909) 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 267909 7142866 ECED1_0243 Escherichia coli ED1a hypothetical protein YP_002396316.1 267712 R 585397 CDS YP_002396317.1 218688105 7142867 267911..268174 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 268174 7142867 ECED1_0244 Escherichia coli ED1a hypothetical protein YP_002396317.1 267911 D 585397 CDS YP_002396318.1 218688106 7142868 268144..268464 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 268464 7142868 ECED1_0245 Escherichia coli ED1a hypothetical protein YP_002396318.1 268144 D 585397 CDS YP_002396319.1 218688107 7142869 268449..269003 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 269003 7142869 ECED1_0246 Escherichia coli ED1a hypothetical protein YP_002396319.1 268449 D 585397 CDS YP_002396320.1 218688108 7142870 268988..269530 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 269530 7142870 ECED1_0247 Escherichia coli ED1a hypothetical protein YP_002396320.1 268988 D 585397 CDS YP_002396321.1 218688109 7142871 269515..271191 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 271191 7142871 ECED1_0248 Escherichia coli ED1a hypothetical protein YP_002396321.1 269515 D 585397 CDS YP_002396322.1 218688110 7141788 271467..271646 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative H-repeat associated protein 271646 7141788 ECED1_0249 Escherichia coli ED1a putative H-repeat associated protein YP_002396322.1 271467 D 585397 CDS YP_002396323.1 218688111 7141789 271746..272147 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transposase 272147 7141789 ECED1_0250 Escherichia coli ED1a putative transposase YP_002396323.1 271746 D 585397 CDS YP_002396324.1 218688112 7141790 272460..272963 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 272963 7141790 ECED1_0251 Escherichia coli ED1a hypothetical protein YP_002396324.1 272460 D 585397 CDS YP_002396325.1 218688113 7141791 273033..273545 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 273545 7141791 ECED1_0252 Escherichia coli ED1a hypothetical protein YP_002396325.1 273033 D 585397 CDS YP_002396326.1 218688114 7141792 complement(273816..274586) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8526497; Product type pe : putative enzyme; hypothetical protein 274586 yafV 7141792 yafV Escherichia coli ED1a hypothetical protein YP_002396326.1 273816 R 585397 CDS YP_002396327.1 218688115 7143396 274740..275213 1 NC_011745.1 inactivates vertebrate C-type lysozyme; C-lysozyme inhibitor 275213 ivy 7143396 ivy Escherichia coli ED1a C-lysozyme inhibitor YP_002396327.1 274740 D 585397 CDS YP_002396328.1 218688116 7142477 complement(275256..277700) 1 NC_011745.1 functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA; acyl-CoA dehydrogenase 277700 fadE 7142477 fadE Escherichia coli ED1a acyl-CoA dehydrogenase YP_002396328.1 275256 R 585397 CDS YP_002396329.1 218688117 7144127 277940..278518 1 NC_011745.1 catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate; phosphoheptose isomerase 278518 gmhA 7144127 gmhA Escherichia coli ED1a phosphoheptose isomerase YP_002396329.1 277940 D 585397 CDS YP_002396330.1 218688118 7141907 278723..279490 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glutamine amidotransferases class-II 279490 yafJ 7141907 yafJ Escherichia coli ED1a putative glutamine amidotransferases class-II YP_002396330.1 278723 D 585397 CDS YP_002396331.1 218688119 7143386 complement(279461..280201) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 280201 yafK 7143386 yafK Escherichia coli ED1a hypothetical protein YP_002396331.1 279461 R 585397 CDS YP_002396332.1 218688120 7143387 280504..281262 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative exported hydrolase 281262 yafL 7143387 yafL Escherichia coli ED1a putative exported hydrolase YP_002396332.1 280504 D 585397 CDS YP_002396333.1 218688121 7143390 complement(282354..284093) 1 NC_011745.1 Evidence 7 : Gene remnant; Product type s : structure; flagellar system protein 284093 fhiA 7143390 fhiA Escherichia coli ED1a flagellar system protein YP_002396333.1 282354 R 585397 CDS YP_002396334.1 218688122 7144167 283933..284823 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 15687208; Product type s : structure; hypothetical protein 284823 mbhA 7144167 mbhA Escherichia coli ED1a hypothetical protein YP_002396334.1 283933 D 585397 CDS YP_002396335.1 218688123 7142217 284894..285949 1 NC_011745.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 285949 dinB 7142217 dinB Escherichia coli ED1a DNA polymerase IV YP_002396335.1 284894 D 585397 CDS YP_002396336.1 218688124 7142030 286001..286294 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12813093, 14594833; Product type pf : putative factor; putative antitoxin of the YafO-YafN toxin-antitoxin system 286294 yafN 7142030 yafN Escherichia coli ED1a putative antitoxin of the YafO-YafN toxin-antitoxin system YP_002396336.1 286001 D 585397 CDS YP_002396337.1 218688125 7143391 286297..286695 1 NC_011745.1 YafO overproduction induces toxicity; it is believed to be the toxin of a toxin-antitoxin pair; unknown function; putative toxin YafO 286695 yafO 7143391 yafO Escherichia coli ED1a putative toxin YafO YP_002396337.1 286297 D 585397 CDS YP_002396338.1 218688126 7143392 286705..287157 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12813093; Product type pe : putative enzyme; hypothetical protein 287157 yafP 7143392 yafP Escherichia coli ED1a hypothetical protein YP_002396338.1 286705 D 585397 CDS YP_002396339.1 218688127 7143393 287335..288486 1 NC_011745.1 mutations in this gene result in a compromised ability for drug-inducible mexXY expression; expression is inducible by the same ribosome-targeting agents that induce mexXY; hypothetical protein 288486 7143393 ECED1_0269 Escherichia coli ED1a hypothetical protein YP_002396339.1 287335 D 585397 CDS YP_002396340.1 218688128 7141793 288597..289097 1 NC_011745.1 similar to release factor 1 and 2; peptide chain release factor-like protein 289097 prfH 7141793 prfH Escherichia coli ED1a peptide chain release factor-like protein YP_002396340.1 288597 D 585397 CDS YP_002396341.1 218688129 7139118 complement(289154..290611) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1695895, 21101837, 88121730, 92204123, 2651887; Product type e : enzyme; aminoacyl-histidine dipeptidase (peptidase D) 290611 pepD 7139118 pepD Escherichia coli ED1a aminoacyl-histidine dipeptidase (peptidase D) YP_002396341.1 289154 R 585397 CDS YP_002396342.1 218688130 7144060 290872..291330 1 NC_011745.1 catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively; xanthine-guanine phosphoribosyltransferase 291330 gpt 7144060 gpt Escherichia coli ED1a xanthine-guanine phosphoribosyltransferase YP_002396342.1 290872 D 585397 CDS YP_002396343.1 218688131 7143016 291422..292666 1 NC_011745.1 forms a 1:1 complex with the unphosphorylated from of enzyme IIAGlc; FrsA may promote fermentation; fermentation/respiration switch protein 292666 frsA 7143016 frsA Escherichia coli ED1a fermentation/respiration switch protein YP_002396343.1 291422 D 585397 CDS YP_002396344.1 218688132 7142176 292724..293125 1 NC_011745.1 involved in the expression of csgBA which is involved in curli formation; interacts with sigmaS; DNA-binding transcriptional regulator Crl 293125 crl 7142176 crl Escherichia coli ED1a DNA-binding transcriptional regulator Crl YP_002396344.1 292724 D 585397 CDS YP_002396345.1 218688133 7142054 complement(293164..294219) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89178658, 89380253, 92219258, 98090453, 1380671, 1848301, 1848682, 6089111, 6341601, 7679770; Product type t : transporter; outer membrane phosphoporin protein E 294219 phoE 7142054 phoE Escherichia coli ED1a outer membrane phosphoporin protein E YP_002396345.1 293164 R 585397 CDS YP_002396346.1 218688134 7144104 294508..295611 1 NC_011745.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 295611 proB 7144104 proB Escherichia coli ED1a gamma-glutamyl kinase YP_002396346.1 294508 D 585397 CDS YP_002396347.1 218688135 7139128 295623..296876 1 NC_011745.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 296876 proA 7139128 proA Escherichia coli ED1a gamma-glutamyl phosphate reductase YP_002396347.1 295623 D 585397 CDS YP_002396348.1 218688136 7140594 297377..298057 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 298057 7140594 ECED1_0278 Escherichia coli ED1a hypothetical protein YP_002396348.1 297377 D 585397 CDS YP_002396349.1 218688137 7141794 complement(298059..299696) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 299696 7141794 ECED1_0279 Escherichia coli ED1a hypothetical protein YP_002396349.1 298059 R 585397 CDS YP_002396350.1 218688138 7141795 300366..300614 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative AlpA-family regulatory protein from prophage 300614 7141795 ECED1_0280 Escherichia coli ED1a putative AlpA-family regulatory protein from prophage YP_002396350.1 300366 D 585397 CDS YP_002396351.1 218688139 7143752 303545..304108 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 304108 7143752 ECED1_0284 Escherichia coli ED1a hypothetical protein YP_002396351.1 303545 D 585397 CDS YP_002396352.1 218688140 7141797 304239..306629 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative helicase 306629 7141797 ECED1_0285 Escherichia coli ED1a putative helicase YP_002396352.1 304239 D 585397 CDS YP_002396353.1 218688141 7141798 complement(306647..307027) 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 307027 7141798 ECED1_0286 Escherichia coli ED1a hypothetical protein YP_002396353.1 306647 R 585397 CDS YP_002396354.1 218688142 7141799 306893..307204 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 307204 7141799 ECED1_0287 Escherichia coli ED1a hypothetical protein YP_002396354.1 306893 D 585397 CDS YP_002396355.1 218688143 7141800 307301..308278 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 308278 7141800 ECED1_0288 Escherichia coli ED1a hypothetical protein YP_002396355.1 307301 D 585397 CDS YP_002396356.1 218688144 7142952 310012..310845 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 310845 7142952 ECED1_0293 Escherichia coli ED1a putative transcriptional regulator YP_002396356.1 310012 D 585397 CDS YP_002396357.1 218688145 7141805 311068..312057 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase, IS110 family 312057 7141805 ECED1_0294 Escherichia coli ED1a transposase, IS110 family YP_002396357.1 311068 D 585397 CDS YP_002396358.1 218688146 7141806 312033..312131 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 312131 7141806 ECED1_0295 Escherichia coli ED1a hypothetical protein YP_002396358.1 312033 D 585397 CDS YP_002396359.1 218688147 7141807 complement(312475..313968) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 2820984, 88007632, 91154204, 2836810, 3543693; Product type t : transporter; D-xylose-proton symporter 313968 xylE 7141807 xylE Escherichia coli ED1a D-xylose-proton symporter YP_002396359.1 312475 R 585397 CDS YP_002396360.1 218688148 7139214 314379..315815 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; Sugar (And other) transporter 315815 7139214 ECED1_0297 Escherichia coli ED1a Sugar (And other) transporter YP_002396360.1 314379 D 585397 CDS YP_002396361.1 218688149 7141808 complement(316227..316709) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase IS605 family, IS200 group 316709 7141808 ECED1_0298 Escherichia coli ED1a transposase IS605 family, IS200 group YP_002396361.1 316227 R 585397 CDS YP_002396362.1 218688150 7141809 complement(316850..317659) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 317659 7141809 ECED1_0299 Escherichia coli ED1a hypothetical protein YP_002396362.1 316850 R 585397 CDS YP_002396363.1 218688151 7141810 complement(317684..319189) 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1339433; Product type e : enzyme; Methylmalonate-semialdehyde dehydrogenase 319189 7141810 ECED1_0300 Escherichia coli ED1a Methylmalonate-semialdehyde dehydrogenase YP_002396363.1 317684 R 585397 CDS YP_002396364.1 218688152 7141811 319579..320448 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative AraC-type DNA-binding domain-containing protein 320448 7141811 ECED1_0301 Escherichia coli ED1a putative AraC-type DNA-binding domain-containing protein YP_002396364.1 319579 D 585397 CDS YP_002396365.1 218688153 7141812 321325..322245 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14993306; Product type e : enzyme; 2-keto-myo-inositol dehydratase 322245 iolE 7141812 iolE Escherichia coli ED1a 2-keto-myo-inositol dehydratase YP_002396365.1 321325 D 585397 CDS YP_002396366.1 218688154 7142445 322246..323274 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1761221, 112095; Product type e : enzyme; inositol 2-dehydrogenase 323274 iolG 7142445 iolG Escherichia coli ED1a inositol 2-dehydrogenase YP_002396366.1 322246 D 585397 CDS YP_002396367.1 218688155 7142446 323372..324715 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10844662; Product type pe : putative enzyme; putative glucosylceramidase 324715 srfJ 7142446 srfJ Escherichia coli ED1a putative glucosylceramidase YP_002396367.1 323372 D 585397 CDS YP_002396368.1 218688156 7143839 324716..325549 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative myo-inositol catabolism protein (iolI-like) 325549 7143839 ECED1_0306 Escherichia coli ED1a putative myo-inositol catabolism protein (iolI-like) YP_002396368.1 324716 D 585397 CDS YP_002396369.1 218688157 7141813 complement(325546..326712) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; major facilitator superfamily transporter 326712 7141813 ECED1_0307 Escherichia coli ED1a major facilitator superfamily transporter YP_002396369.1 325546 R 585397 CDS YP_002396370.1 218688158 7141816 complement(328106..328453) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1310503, 1321417; putative IS91 orf2 328453 7141816 ECED1_0310 Escherichia coli ED1a putative IS91 orf2 YP_002396370.1 328106 R 585397 CDS YP_002396371.1 218688159 7141817 complement(328589..330526) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative carbohydrate kinase 330526 7141817 ECED1_0311 Escherichia coli ED1a putative carbohydrate kinase YP_002396371.1 328589 R 585397 CDS YP_002396372.1 218688160 7141818 330931..332880 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1577690, 11497462; Product type pe : putative enzyme; putative malonic semialdehyde oxidative decarboxylase (iolD-like) 332880 7141818 ECED1_0314 Escherichia coli ED1a putative malonic semialdehyde oxidative decarboxylase (iolD-like) YP_002396372.1 330931 D 585397 CDS YP_002396373.1 218688161 7141819 333061..334083 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative myo-inositol 2-dehydrogenase (iolG-like) 334083 7141819 ECED1_0315 Escherichia coli ED1a putative myo-inositol 2-dehydrogenase (iolG-like) YP_002396373.1 333061 D 585397 CDS YP_002396374.1 218688162 7141820 334156..335382 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9099855; Product type pt : putative transporter; putative permeases of the major facilitator superfamily MFS 335382 7141820 ECED1_0316 Escherichia coli ED1a putative permeases of the major facilitator superfamily MFS YP_002396374.1 334156 D 585397 CDS YP_002396375.1 218688163 7141821 complement(335519..335662) 1 NC_011745.1 Evidence 7 : Gene remnant; hypothetical protein 335662 7141821 ECED1_0317 Escherichia coli ED1a hypothetical protein YP_002396375.1 335519 R 585397 CDS YP_002396376.1 218688164 7141822 335652..336053 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative transposase, IS3 family 336053 7141822 ECED1_0318 Escherichia coli ED1a putative transposase, IS3 family YP_002396376.1 335652 D 585397 CDS YP_002396377.1 218688165 7141823 336050..336397 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative transposase ORF2, IS66 family 336397 7141823 ECED1_0319 Escherichia coli ED1a putative transposase ORF2, IS66 family YP_002396377.1 336050 D 585397 CDS YP_002396378.1 218688166 7141824 336447..337853 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transposase ORF 1, IS66 family 337853 7141824 ECED1_0320 Escherichia coli ED1a putative transposase ORF 1, IS66 family YP_002396378.1 336447 D 585397 CDS YP_002396379.1 218688167 7141825 338061..338222 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 338222 7141825 ECED1_0321 Escherichia coli ED1a hypothetical protein YP_002396379.1 338061 D 585397 CDS YP_002396380.1 218688168 7141826 338315..339547 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative reverse transcriptase 339547 7141826 ECED1_0322 Escherichia coli ED1a putative reverse transcriptase YP_002396380.1 338315 D 585397 CDS YP_002396381.1 218688169 7140766 339663..339809 1 NC_011745.1 Evidence 7 : Gene remnant; hypothetical protein 339809 7140766 ECED1_0323 Escherichia coli ED1a hypothetical protein YP_002396381.1 339663 D 585397 CDS YP_002396382.1 218688170 7141828 complement(339839..340378) 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15385522, 15075407; Product type e : enzyme; Deoxyribose specific mutarotase (partial) 340378 deoM 7141828 deoM Escherichia coli ED1a Deoxyribose specific mutarotase (partial) YP_002396382.1 339839 R 585397 CDS YP_002396383.1 218688171 7143094 complement(340390..341706) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 5385522, 15075407, 10648508; Product type pe : putative enzyme; putative L-fucose permease 341706 deoP 7143094 deoP Escherichia coli ED1a putative L-fucose permease YP_002396383.1 340390 R 585397 CDS YP_002396384.1 218688172 7143095 complement(341734..342750) 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10648508, 15385522; Product type e : enzyme; Deoxyribokinase 342750 deoK 7143095 deoK Escherichia coli ED1a Deoxyribokinase YP_002396384.1 341734 R 585397 CDS YP_002396385.1 218688173 7143093 342954..343739 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15385522, 10648508; Product type pr : putative regulator; putative transcriptional regulator 343739 deoQ 7143093 deoQ Escherichia coli ED1a putative transcriptional regulator YP_002396385.1 342954 D 585397 CDS YP_002396386.1 218688174 7143096 343916..344089 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 344089 7143096 ECED1_0328 Escherichia coli ED1a hypothetical protein YP_002396386.1 343916 D 585397 CDS YP_002396387.1 218688175 7141830 345343..345606 1 NC_011745.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 type B 345606 rpmE2 7141830 rpmE2 Escherichia coli ED1a 50S ribosomal protein L31 type B YP_002396387.1 345343 D 585397 CDS YP_002396388.1 218688176 7140954 346782..347372 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 347372 ykgK 7140954 ykgK Escherichia coli ED1a putative transcriptional regulator YP_002396388.1 346782 D 585397 CDS YP_002396389.1 218688177 7140953 347496..347771 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 347771 insA 7140953 insA Escherichia coli ED1a IS1 repressor protein InsA YP_002396389.1 347496 D 585397 CDS YP_002396390.1 218688178 7141113 347690..348193 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 348193 insB 7141113 insB Escherichia coli ED1a IS1 transposase InsAB' YP_002396390.1 347690 D 585397 CDS YP_002396391.1 218688179 7141136 348223..348810 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 17563352, 11466275; Product type s : structure; common pilus ECP 348810 ecpA 7141136 ecpA Escherichia coli ED1a common pilus ECP YP_002396391.1 348223 D 585397 CDS YP_002396392.1 218688180 7139770 348867..349535 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 349535 yagY 7139770 yagY Escherichia coli ED1a hypothetical protein YP_002396392.1 348867 D 585397 CDS YP_002396393.1 218688181 7143399 349561..352086 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 352086 yagX 7143399 yagX Escherichia coli ED1a hypothetical protein YP_002396393.1 349561 D 585397 CDS YP_002396394.1 218688182 7143397 353155..353931 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative reductase 353931 7143397 ECED1_0339 Escherichia coli ED1a putative reductase YP_002396394.1 353155 D 585397 CDS YP_002396395.1 218688183 7141831 complement(354091..354684) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 354684 ykgB 7141831 ykgB Escherichia coli ED1a hypothetical protein YP_002396395.1 354091 R 585397 CDS YP_002396396.1 218688184 7140944 complement(354696..354932) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 354932 ykgI 7140944 ykgI Escherichia coli ED1a hypothetical protein YP_002396396.1 354696 R 585397 CDS YP_002396397.1 218688185 7140952 complement(355041..356366) 1 NC_011745.1 Involved in disulfide oxidoreductase activity and electron transport; pyridine nucleotide-disulfide oxidoreductase 356366 ykgC 7140952 ykgC Escherichia coli ED1a pyridine nucleotide-disulfide oxidoreductase YP_002396397.1 355041 R 585397 CDS YP_002396398.1 218688186 7140945 356593..357447 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative AraC-type DNA-binding transcriptional regulator 357447 ykgD 7140945 ykgD Escherichia coli ED1a putative AraC-type DNA-binding transcriptional regulator YP_002396398.1 356593 D 585397 CDS YP_002396399.1 218688187 7140946 357974..358693 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydroxyacid oxidoreductase (Fe-S centre) 358693 ykgE 7140946 ykgE Escherichia coli ED1a putative hydroxyacid oxidoreductase (Fe-S centre) YP_002396399.1 357974 D 585397 CDS YP_002396400.1 218688188 7140947 358704..360131 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase subunit with NAD(P)-binding domain and ferridoxin-like domain 360131 ykgF 7140947 ykgF Escherichia coli ED1a putative oxidoreductase subunit with NAD(P)-binding domain and ferridoxin-like domain YP_002396400.1 358704 D 585397 CDS YP_002396401.1 218688189 7140948 360124..360819 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 360819 ykgG 7140948 ykgG Escherichia coli ED1a hypothetical protein YP_002396401.1 360124 D 585397 CDS YP_002396402.1 218688190 7140950 complement(360893..361090) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 361090 7140950 ECED1_0347 Escherichia coli ED1a hypothetical protein YP_002396402.1 360893 R 585397 CDS YP_002396403.1 218688191 7141832 complement(361062..361730) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 361730 ykgH 7141832 ykgH Escherichia coli ED1a hypothetical protein YP_002396403.1 361062 R 585397 CDS YP_002396404.1 218688192 7140951 complement(361914..363905) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative adhesin 363905 7140951 ECED1_0349 Escherichia coli ED1a putative adhesin YP_002396404.1 361914 R 585397 CDS YP_002396405.1 218688193 7141833 364115..365425 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative enzyme with acyl-CoA domain 365425 yahF 7141833 yahF Escherichia coli ED1a putative enzyme with acyl-CoA domain YP_002396405.1 364115 D 585397 CDS YP_002396406.1 218688194 7143400 365425..366843 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 366843 yahG 7143400 yahG Escherichia coli ED1a hypothetical protein YP_002396406.1 365425 D 585397 CDS YP_002396407.1 218688195 7143401 367090..368040 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7711027, 11523892; Product type pe : putative enzyme; putative carbamate kinase 368040 yahI 7143401 yahI Escherichia coli ED1a putative carbamate kinase YP_002396407.1 367090 D 585397 CDS YP_002396408.1 218688196 7143402 368050..369432 1 NC_011745.1 metallo-dependent hydrolase superfamily; deaminase with metallo-dependent hydrolase domain; putative deaminase 369432 yahJ 7143402 yahJ Escherichia coli ED1a putative deaminase YP_002396408.1 368050 D 585397 CDS YP_002396409.1 218688197 7143403 369696..370139 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 370139 7143403 ECED1_0354 Escherichia coli ED1a hypothetical protein YP_002396409.1 369696 D 585397 CDS YP_002396410.1 218688198 7141834 370390..371376 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; ribose ABC transporter substrate-binding protein 371376 7141834 ECED1_0355 Escherichia coli ED1a ribose ABC transporter substrate-binding protein YP_002396410.1 370390 D 585397 CDS YP_002396411.1 218688199 7141835 371410..372909 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ATP-binding protein of ABC sugar transport system 372909 7141835 ECED1_0356 Escherichia coli ED1a putative ATP-binding protein of ABC sugar transport system YP_002396411.1 371410 D 585397 CDS YP_002396412.1 218688200 7141836 372902..373873 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; sugar ABC transporter permease 373873 7141836 ECED1_0357 Escherichia coli ED1a sugar ABC transporter permease YP_002396412.1 372902 D 585397 CDS YP_002396413.1 218688201 7141837 373840..374826 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; sugar ABC transporter permease 374826 7141837 ECED1_0358 Escherichia coli ED1a sugar ABC transporter permease YP_002396413.1 373840 D 585397 CDS YP_002396414.1 218688202 7141838 374913..375962 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase, Zn-dependent and NAD(P)-binding 375962 yahK 7141838 yahK Escherichia coli ED1a putative oxidoreductase, Zn-dependent and NAD(P)-binding YP_002396414.1 374913 D 585397 CDS YP_002396415.1 218688203 7140605 376554..376733 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 376733 7140605 ECED1_0360 Escherichia coli ED1a hypothetical protein YP_002396415.1 376554 D 585397 CDS YP_002396416.1 218688204 7141839 complement(376844..377515) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12879215; Product type t : transporter; neutral amino-acid efflux system 377515 yahN 7141839 yahN Escherichia coli ED1a neutral amino-acid efflux system YP_002396416.1 376844 R 585397 CDS YP_002396417.1 218688205 7143405 377662..377937 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 377937 yahO 7143405 yahO Escherichia coli ED1a hypothetical protein YP_002396417.1 377662 D 585397 CDS YP_002396418.1 218688206 7143406 complement(378038..379624) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9325432, 15805526; Product type r : regulator; DNA-binding transcriptional activator 379624 prpR 7143406 prpR Escherichia coli ED1a DNA-binding transcriptional activator YP_002396418.1 378038 R 585397 CDS YP_002396419.1 218688207 7141185 379863..380753 1 NC_011745.1 catalyzes the formation of pyruvate and succinate from 2-methylisocitrate; 2-methylisocitrate lyase 380753 prpB 7141185 prpB Escherichia coli ED1a 2-methylisocitrate lyase YP_002396419.1 379863 D 585397 CDS YP_002396420.1 218688208 7139137 380913..382082 1 NC_011745.1 catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity; methylcitrate synthase 382082 prpC 7139137 prpC Escherichia coli ED1a methylcitrate synthase YP_002396420.1 380913 D 585397 CDS YP_002396421.1 218688209 7139138 382116..383567 1 NC_011745.1 functions in propionate metabolism; involved in isomerization of (2S,3S)-methylcitrate to (2R,3S)-methylisocitrate; also encodes minor aconitase or dehydratase activity; aconitase C; 2-methylcitrate dehydratase 383567 prpD 7139138 prpD Escherichia coli ED1a 2-methylcitrate dehydratase YP_002396421.1 382116 D 585397 CDS YP_002396422.1 218688210 7139139 383607..385493 1 NC_011745.1 catalyzes the formation of propionyl-CoA using propionate as a substrate; PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A; not expressed in Escherichia coli when grown on propionate/minimal media; ATP-dependent; propionyl-CoA synthetase 385493 prpE 7139139 prpE Escherichia coli ED1a propionyl-CoA synthetase YP_002396422.1 383607 D 585397 CDS YP_002396423.1 218688211 7141102 385724..386983 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92349961; Product type t : transporter; cytosine permease 386983 codB 7141102 codB Escherichia coli ED1a cytosine permease YP_002396423.1 385724 D 585397 CDS YP_002396424.1 218688212 7142037 386973..388256 1 NC_011745.1 Catalyzes the deamination of cytosine to uracil and ammonia; cytosine deaminase 388256 codA 7142037 codA Escherichia coli ED1a cytosine deaminase YP_002396424.1 386973 D 585397 CDS YP_002396425.1 218688213 7142036 complement(388377..388988) 1 NC_011745.1 transfers acetyl group from acetyl-CoA to the 6-hydroxyl of galactopyranosides; exact physiological role is unknown; galactoside O-acetyltransferase 388988 lacA 7142036 lacA Escherichia coli ED1a galactoside O-acetyltransferase YP_002396425.1 388377 R 585397 CDS YP_002396426.1 218688214 7141864 complement(389054..390307) 1 NC_011745.1 lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments; galactoside permease 390307 lacY 7141864 lacY Escherichia coli ED1a galactoside permease YP_002396426.1 389054 R 585397 CDS YP_002396427.1 218688215 7141866 complement(390359..393433) 1 NC_011745.1 forms a homotetramer; hydrolyzes lactose disaccharide to galactose and glucose; converts lactose to allolactose which is the natural inducer of the lac operon; beta-D-galactosidase 393433 lacZ 7141866 lacZ Escherichia coli ED1a beta-D-galactosidase YP_002396427.1 390359 R 585397 CDS YP_002396428.1 218688216 7141867 complement(393556..394638) 1 NC_011745.1 transcriptional repressor of lac operon; forms a homotetramer as a dimer of dimers; binds specific sites in lac operon resulting in DNA looping between the operators; binds allolactose as inducer; lac repressor 394638 lacI 7141867 lacI Escherichia coli ED1a lac repressor YP_002396428.1 393556 R 585397 CDS YP_002396429.1 218688217 7141865 complement(394715..395629) 1 NC_011745.1 activator of 3-phenylpropionic acid catabolism; DNA-binding transcriptional activator MhpR 395629 mhpR 7141865 mhpR Escherichia coli ED1a DNA-binding transcriptional activator MhpR YP_002396429.1 394715 R 585397 CDS YP_002396430.1 218688218 7142275 395740..397404 1 NC_011745.1 catalyzes the formation of 3-(2,3-dihydroxyphenyl)propionate from 3-(3-hydroxyphenyl)propionate; 3-(3-hydroxyphenyl)propionate hydroxylase 397404 mhpA 7142275 mhpA Escherichia coli ED1a 3-(3-hydroxyphenyl)propionate hydroxylase YP_002396430.1 395740 D 585397 CDS YP_002396431.1 218688219 7142269 397406..398350 1 NC_011745.1 catalyzes the cleavage of 3-(2,3-dihydroxyphenyl) propionate into 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate; part of the 3-phenylpropionic acid degradation pathway; member of the protocatechuate 4,5-dioxygenase family; 3-(2,3-dihydroxyphenyl)propionate dioxygenase 398350 mhpB 7142269 mhpB Escherichia coli ED1a 3-(2,3-dihydroxyphenyl)propionate dioxygenase YP_002396431.1 397406 D 585397 CDS YP_002396432.1 218688220 7142270 398353..399234 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87008429, 94002258, 15663942; Product type e : enzyme; 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase 399234 mhpC 7142270 mhpC Escherichia coli ED1a 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase YP_002396432.1 398353 D 585397 CDS YP_002396433.1 218688221 7142271 399244..400053 1 NC_011745.1 catalyzes the formation of 2-keto-4-hydroxypentanoic acid from 2-hydroxypentadienoic acid; 2-keto-4-pentenoate hydratase 400053 mhpD 7142271 mhpD Escherichia coli ED1a 2-keto-4-pentenoate hydratase YP_002396433.1 399244 D 585397 CDS YP_002396434.1 218688222 7142272 400050..401000 1 NC_011745.1 catalyzes the formation of acetyl-CoA from acetalaldehyde; acetaldehyde dehydrogenase 401000 mhpF 7142272 mhpF Escherichia coli ED1a acetaldehyde dehydrogenase YP_002396434.1 400050 D 585397 CDS YP_002396435.1 218688223 7142274 400997..402010 1 NC_011745.1 catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate; 4-hydroxy-2-ketovalerate aldolase 402010 mhpE 7142274 mhpE Escherichia coli ED1a 4-hydroxy-2-ketovalerate aldolase YP_002396435.1 400997 D 585397 CDS YP_002396436.1 218688224 7142273 402186..403397 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 7961399; Product type t : transporter; putative 3-hydroxyphenylpropionic transporter MhpT 403397 mhpT 7142273 mhpT Escherichia coli ED1a putative 3-hydroxyphenylpropionic transporter MhpT YP_002396436.1 402186 D 585397 CDS YP_002396437.1 218688225 7138977 403499..404038 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15115803, 12878731, 13129938; Product type e : enzyme; nucleoprotein/polynucleotide-associated enzyme 404038 yaiL 7138977 yaiL Escherichia coli ED1a nucleoprotein/polynucleotide-associated enzyme YP_002396437.1 403499 D 585397 CDS YP_002396438.1 218688226 7143412 complement(404265..405098) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16567800, 15466022; Product type e : enzyme; S-formylglutathione hydrolase 405098 frmB 7143412 frmB Escherichia coli ED1a S-formylglutathione hydrolase YP_002396438.1 404265 R 585397 CDS YP_002396439.1 218688227 7142172 complement(405191..406300) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15466022, 87172301, 1731906; Product type e : enzyme; alcohol dehydrogenase class III/glutathione-dependent formaldehyde dehydrogenase 406300 frmA 7142172 frmA Escherichia coli ED1a alcohol dehydrogenase class III/glutathione-dependent formaldehyde dehydrogenase YP_002396439.1 405191 R 585397 CDS YP_002396440.1 218688228 7142171 complement(406335..406610) 1 NC_011745.1 formaldehyde-induced negative regulator of the frmRAB operon; regulator protein FrmR 406610 frmR 7142171 frmR Escherichia coli ED1a regulator protein FrmR YP_002396440.1 406335 R 585397 CDS YP_002396441.1 218688229 7143414 complement(407573..408283) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transferase 408283 yaiX 7143414 yaiX Escherichia coli ED1a putative transferase YP_002396441.1 407573 R 585397 CDS YP_002396442.1 218688230 7143418 complement(408132..409328) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-associated glycosyltransferase 409328 yaiP 7143418 yaiP Escherichia coli ED1a putative membrane-associated glycosyltransferase YP_002396442.1 408132 R 585397 CDS YP_002396443.1 218688231 7143415 complement(409338..410024) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 410024 yaiS 7143415 yaiS Escherichia coli ED1a hypothetical protein YP_002396443.1 409338 R 585397 CDS YP_002396444.1 218688232 7143416 410617..411579 1 NC_011745.1 with TauB and TauC is responsible for taurine uptake.; taurine transporter substrate binding subunit 411579 tauA 7143416 tauA Escherichia coli ED1a taurine transporter substrate binding subunit YP_002396444.1 410617 D 585397 CDS YP_002396445.1 218688233 7141517 411592..412359 1 NC_011745.1 Part of the ABC transporter complex tauABC involved in taurine import; taurine transporter ATP-binding subunit 412359 tauB 7141517 tauB Escherichia coli ED1a taurine transporter ATP-binding subunit YP_002396445.1 411592 D 585397 CDS YP_002396446.1 218688234 7141518 412356..413183 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9401024, 96404792; Product type t : transporter; taurine transporter subunit 413183 tauC 7141518 tauC Escherichia coli ED1a taurine transporter subunit YP_002396446.1 412356 D 585397 CDS YP_002396447.1 218688235 7141519 413180..414031 1 NC_011745.1 catalyzes the conversion of taurine (2-aminoethanesulfonate) to sulfite and aminoacetaldehyde concurrently with the conversion of alpha-ketoglutarate to succinate and carbon dioxide; non-heme iron oxidase; allows the use of taurine as an alternative sulfur source; forms homodimers; taurine dioxygenase 414031 tauD 7141519 tauD Escherichia coli ED1a taurine dioxygenase YP_002396447.1 413180 D 585397 CDS YP_002396448.1 218688236 7141520 complement(414071..415045) 1 NC_011745.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 415045 hemB 7141520 hemB Escherichia coli ED1a delta-aminolevulinic acid dehydratase YP_002396448.1 414071 R 585397 CDS YP_002396449.1 218688237 7139866 complement(415220..415723) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 415723 insB 7139866 insB Escherichia coli ED1a IS1 transposase InsAB' YP_002396449.1 415220 R 585397 CDS YP_002396450.1 218688238 7141137 complement(415642..415917) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 415917 insA 7141137 insA Escherichia coli ED1a IS1 repressor protein InsA YP_002396450.1 415642 R 585397 CDS YP_002396451.1 218688239 7141114 complement(416099..417256) 1 NC_011745.1 this protein has no known enzymatic function; beta-lactam binding protein AmpH 417256 ampH 7141114 ampH Escherichia coli ED1a beta-lactam binding protein AmpH YP_002396451.1 416099 R 585397 CDS YP_002396452.1 218688240 7143710 417608..418828 1 NC_011745.1 in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope; transport protein 418828 sbmA 7143710 sbmA Escherichia coli ED1a transport protein YP_002396452.1 417608 D 585397 CDS YP_002396453.1 218688241 7141374 418841..419935 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative lipoprotein 419935 yaiW 7141374 yaiW Escherichia coli ED1a putative lipoprotein YP_002396453.1 418841 D 585397 CDS YP_002396454.1 218688242 7143417 complement(419993..420301) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 420301 yaiY 7143417 yaiY Escherichia coli ED1a hypothetical protein YP_002396454.1 419993 R 585397 CDS YP_002396455.1 218688243 7143419 420429..420773 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 420773 yaiZ 7143419 yaiZ Escherichia coli ED1a hypothetical protein YP_002396455.1 420429 D 585397 CDS YP_002396456.1 218688244 7143420 complement(420797..421891) 1 NC_011745.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 421891 ddl 7143420 ddl Escherichia coli ED1a D-alanyl-alanine synthetase A YP_002396456.1 420797 R 585397 CDS YP_002396457.1 218688245 7143080 422354..422614 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 422614 yaiB 7143080 yaiB Escherichia coli ED1a hypothetical protein YP_002396457.1 422354 D 585397 CDS YP_002396458.1 218688246 7143408 422715..424130 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type e : enzyme; alkaline phosphatase 424130 phoA 7143408 phoA Escherichia coli ED1a alkaline phosphatase YP_002396458.1 422715 D 585397 CDS YP_002396459.1 218688247 7144102 424249..424569 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3533724, 2160940; Product type f : factor; hypothetical protein 424569 psiF 7144102 psiF Escherichia coli ED1a hypothetical protein YP_002396459.1 424249 D 585397 CDS YP_002396460.1 218688248 7141189 424671..425786 1 NC_011745.1 catalyzes the conversion of 2 GTP into c-di-GMP; adrA overexpression induces cellulose biosynthesis, cell adherence to abiotic surfaces and swimming and swarming motility; AdrA acts post-transcriptionally on the bcsABZC operon activating cellulose biosynthesis; diguanylate cyclase AdrA 425786 adrA 7141189 adrA Escherichia coli ED1a diguanylate cyclase AdrA YP_002396460.1 424671 D 585397 CDS YP_002396461.1 218688249 7143409 complement(425803..426612) 1 NC_011745.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase 426612 proC 7143409 proC Escherichia coli ED1a pyrroline-5-carboxylate reductase YP_002396461.1 425803 R 585397 CDS YP_002396462.1 218688250 7139129 426732..427190 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 427190 yaiI 7139129 yaiI Escherichia coli ED1a hypothetical protein YP_002396462.1 426732 D 585397 CDS YP_002396463.1 218688251 7143411 427373..427897 1 NC_011745.1 type II enzyme similar to type I but differentially regulated and with a lower Km; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase II 427897 aroL 7143411 aroL Escherichia coli ED1a shikimate kinase II YP_002396463.1 427373 D 585397 CDS YP_002396464.1 218688252 7142632 427947..428138 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 428138 yaiA 7142632 yaiA Escherichia coli ED1a hypothetical protein YP_002396464.1 427947 D 585397 CDS YP_002396465.1 218688253 7143407 428396..429073 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 86085675, 3001025; hypothetical protein 429073 aroM 7143407 aroM Escherichia coli ED1a hypothetical protein YP_002396465.1 428396 D 585397 CDS YP_002396466.1 218688254 7142633 429145..429429 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 429429 yaiE 7142633 yaiE Escherichia coli ED1a hypothetical protein YP_002396466.1 429145 D 585397 CDS YP_002396467.1 218688255 7143410 429637..429915 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 429915 ykiA 7143410 ykiA Escherichia coli ED1a hypothetical protein YP_002396467.1 429637 D 585397 CDS YP_002396468.1 218688256 7140956 complement(430073..430984) 1 NC_011745.1 Required for efficient pilin antigenic variation; recombination associated protein 430984 rdgC 7140956 rdgC Escherichia coli ED1a recombination associated protein YP_002396468.1 430073 R 585397 CDS YP_002396469.1 218688257 7141572 431109..432017 1 NC_011745.1 catalyzes phosphorylation of fructose; cytosolic enzyme; fructokinase 432017 mak 7141572 mak Escherichia coli ED1a fructokinase YP_002396469.1 431109 D 585397 CDS YP_002396470.1 218688258 7141943 complement(432286..433470) 1 NC_011745.1 member of the major facilitator superfamily (MFS) of transporters; unknown function; may be associated with transport or processing of arabinose polymers; MFS transport protein AraJ 433470 araJ 7141943 araJ Escherichia coli ED1a MFS transport protein AraJ YP_002396470.1 432286 R 585397 CDS YP_002396471.1 218688259 7142604 complement(433596..436739) 1 NC_011745.1 with SbcD cleaves DNA hairpin structures; also has 5' single-strand endonuclease activity; exonuclease subunit SbcC 436739 sbcC 7142604 sbcC Escherichia coli ED1a exonuclease subunit SbcC YP_002396471.1 433596 R 585397 CDS YP_002396472.1 218688260 7141372 complement(436736..437938) 1 NC_011745.1 with SbcC cleaves DNA hairpin structure, also has 5' single-strand endonuclease activity; exonuclease subunit SbcD 437938 sbcD 7141372 sbcD Escherichia coli ED1a exonuclease subunit SbcD YP_002396472.1 436736 R 585397 CDS YP_002396473.1 218688261 7141373 438128..438817 1 NC_011745.1 two component response regulator for the phosphate regulon; PhoR phosphorylates PhoB; transcriptional regulator PhoB 438817 phoB 7141373 phoB Escherichia coli ED1a transcriptional regulator PhoB YP_002396473.1 438128 D 585397 CDS YP_002396474.1 218688262 7144103 438875..440170 1 NC_011745.1 membrane-associated histidine protein kinase that phosphorylates phoB in response to environmental signals as part of the two-component phosphate regulatory system phoR/phoB; phosphate regulon sensor protein 440170 phoR 7144103 phoR Escherichia coli ED1a phosphate regulon sensor protein YP_002396474.1 438875 D 585397 CDS YP_002396475.1 218688263 7144108 complement(440181..440291) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 440291 7144108 ECED1_0423 Escherichia coli ED1a hypothetical protein YP_002396475.1 440181 R 585397 CDS YP_002396476.1 218688264 7141840 440577..441896 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 3078876, 6998958, 3550103, 7984428; Product type t : transporter; branched chain amino acid transporter 441896 brnQ 7141840 brnQ Escherichia coli ED1a branched chain amino acid transporter YP_002396476.1 440577 D 585397 CDS YP_002396477.1 218688265 7140462 441972..443345 1 NC_011745.1 cryptic permease that may be involved in the transport of proline across the inner membrane; in Salmonella typhimurium, the proY gene is silent unless overexpressed on a multicopy plasmid or activated by a proZ mutation; putative proline-specific permease 443345 proY 7140462 proY Escherichia coli ED1a putative proline-specific permease YP_002396477.1 441972 D 585397 CDS YP_002396478.1 218688266 7139136 443501..445318 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92184757, 1706703, 1918057; Product type e : enzyme; maltodextrin glucosidase 445318 malZ 7139136 malZ Escherichia coli ED1a maltodextrin glucosidase YP_002396478.1 443501 D 585397 CDS YP_002396479.1 218688267 7142206 complement(445323..445904) 1 NC_011745.1 Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP; acyl carrier protein phosphodiesterase 445904 acpH 7142206 acpH Escherichia coli ED1a acyl carrier protein phosphodiesterase YP_002396479.1 445323 R 585397 CDS YP_002396480.1 218688268 7143645 445997..447067 1 NC_011745.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine:tRNA ribosyltransferase-isomerase 447067 queA 7143645 queA Escherichia coli ED1a S-adenosylmethionine:tRNA ribosyltransferase-isomerase YP_002396480.1 445997 D 585397 CDS YP_002396481.1 218688269 7141244 447122..448249 1 NC_011745.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 448249 tgt 7141244 tgt Escherichia coli ED1a queuine tRNA-ribosyltransferase YP_002396481.1 447122 D 585397 CDS YP_002396482.1 218688270 7141538 448272..448604 1 NC_011745.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 448604 yajC 7141538 yajC Escherichia coli ED1a preprotein translocase subunit YajC YP_002396482.1 448272 D 585397 CDS YP_002396483.1 218688271 7143421 448632..450479 1 NC_011745.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 450479 secD 7143421 secD Escherichia coli ED1a preprotein translocase subunit SecD YP_002396483.1 448632 D 585397 CDS YP_002396484.1 218688272 7141387 450490..451461 1 NC_011745.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 451461 secF 7141387 secF Escherichia coli ED1a preprotein translocase subunit SecF YP_002396484.1 450490 D 585397 CDS YP_002396485.1 218688273 7141389 451591..451938 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 451938 yajD 7141389 yajD Escherichia coli ED1a hypothetical protein YP_002396485.1 451591 D 585397 CDS YP_002396486.1 218688274 7143422 complement(451976..452860) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91092502, 91358319, 93352541; Product type m : membrane component; nucleoside channel phage T6/colicin K receptor 452860 tsx 7143422 tsx Escherichia coli ED1a nucleoside channel phage T6/colicin K receptor YP_002396486.1 451976 R 585397 CDS YP_002396487.1 218688275 7140837 complement(453159..453698) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein 453698 yajI 7140837 yajI Escherichia coli ED1a hypothetical protein YP_002396487.1 453159 R 585397 CDS YP_002396488.1 218688276 7143424 453849..454298 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; transcriptional regulator NrdR 454298 nrdR 7143424 nrdR Escherichia coli ED1a transcriptional regulator NrdR YP_002396488.1 453849 D 585397 CDS YP_002396489.1 218688277 7139927 454302..455405 1 NC_011745.1 riboflavin biosynthesis protein which catalyzes the deamination and reduction steps in the riboflavin biosynthesis pathway; catalyzes the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 5-amino-6-(5-phosphoribitylamino)uracil; bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase 455405 ribD 7139927 ribD Escherichia coli ED1a bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase YP_002396489.1 454302 D 585397 CDS YP_002396490.1 218688278 7141410 455494..455964 1 NC_011745.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 455964 ribH 7141410 ribH Escherichia coli ED1a 6,7-dimethyl-8-ribityllumazine synthase YP_002396490.1 455494 D 585397 CDS YP_002396491.1 218688279 7141411 455984..456403 1 NC_011745.1 Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 456403 nusB 7141411 nusB Escherichia coli ED1a transcription antitermination protein NusB YP_002396491.1 455984 D 585397 CDS YP_002396492.1 218688280 7139960 456481..457458 1 NC_011745.1 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase 457458 thiL 7139960 thiL Escherichia coli ED1a thiamine monophosphate kinase YP_002396492.1 456481 D 585397 CDS YP_002396493.1 218688281 7141546 457436..457954 1 NC_011745.1 hydrolyzes phosphatidylglycerophosphate to produce phosphatidylglycerol and phosphate; phosphatidylglycerophosphatase A 457954 pgpA 7141546 pgpA Escherichia coli ED1a phosphatidylglycerophosphatase A YP_002396493.1 457436 D 585397 CDS YP_002396494.1 218688282 7144078 complement(458008..458982) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15292217, 16077126; Product type e : enzyme; aldoketo-oxidoreductase, NADP-binding 458982 yajO 7144078 yajO Escherichia coli ED1a aldoketo-oxidoreductase, NADP-binding YP_002396494.1 458008 R 585397 CDS YP_002396495.1 218688283 7143426 complement(459037..460899) 1 NC_011745.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 460899 dxs 7143426 dxs Escherichia coli ED1a 1-deoxy-D-xylulose-5-phosphate synthase YP_002396495.1 459037 R 585397 CDS YP_002396496.1 218688284 7139759 complement(460924..461823) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89291702, 91210228; Product type e : enzyme; geranyltranstransferase 461823 ispA 7139759 ispA Escherichia coli ED1a geranyltranstransferase YP_002396496.1 460924 R 585397 CDS YP_002396497.1 218688285 7142462 complement(461823..462065) 1 NC_011745.1 catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 462065 xseB 7142462 xseB Escherichia coli ED1a exodeoxyribonuclease VII small subunit YP_002396497.1 461823 R 585397 CDS YP_002396498.1 218688286 7139210 462271..463719 1 NC_011745.1 Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 463719 thiI 7139210 thiI Escherichia coli ED1a thiamine biosynthesis protein ThiI YP_002396498.1 462271 D 585397 CDS YP_002396499.1 218688287 7141545 complement(463773..464363) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 97039868, 99173753, 99311269; DJ-1 family protein 464363 yajL 7141545 yajL Escherichia coli ED1a DJ-1 family protein YP_002396499.1 463773 R 585397 CDS YP_002396500.1 218688288 7143425 complement(464326..465237) 1 NC_011745.1 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis; 2-dehydropantoate 2-reductase 465237 panE 7143425 panE Escherichia coli ED1a 2-dehydropantoate 2-reductase YP_002396500.1 464326 R 585397 CDS YP_002396501.1 218688289 7144042 465405..465896 1 NC_011745.1 putative nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription; putative nucleotide-binding protein 465896 yajQ 7144042 yajQ Escherichia coli ED1a putative nucleotide-binding protein YP_002396501.1 465405 D 585397 CDS YP_002396502.1 218688290 7143427 complement(466024..467388) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter 467388 yajR 7143427 yajR Escherichia coli ED1a putative MFS superfamily transporter YP_002396502.1 466024 R 585397 CDS YP_002396503.1 218688291 7143428 complement(467537..468427) 1 NC_011745.1 converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase 468427 cyoE 7143428 cyoE Escherichia coli ED1a protoheme IX farnesyltransferase YP_002396503.1 467537 R 585397 CDS YP_002396504.1 218688292 7142106 complement(468439..468768) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90330636, 90366572, 92345252, 9378722, 98021084, 11017202, 2162835; Product type c : carrier; cytochrome o ubiquinol oxidase subunit IV 468768 cyoD 7142106 cyoD Escherichia coli ED1a cytochrome o ubiquinol oxidase subunit IV YP_002396504.1 468439 R 585397 CDS YP_002396505.1 218688293 7142105 complement(468768..469382) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90330636, 92345252, 93349845, 9378722, 98021084, 11017202, 2162835, 2168206; Product type c : carrier; cytochrome o ubiquinol oxidase subunit III 469382 cyoC 7142105 cyoC Escherichia coli ED1a cytochrome o ubiquinol oxidase subunit III YP_002396505.1 468768 R 585397 CDS YP_002396506.1 218688294 7142104 complement(469372..471363) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90330636, 92345252, 93349845, 9378722, 98021084, 11017202, 2162835, 2168206; Product type c : carrier; cytochrome o ubiquinol oxidase subunit I 471363 cyoB 7142104 cyoB Escherichia coli ED1a cytochrome o ubiquinol oxidase subunit I YP_002396506.1 469372 R 585397 CDS YP_002396507.1 218688295 7142103 complement(471385..472332) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92112945, 92371427, 9378722, 98021084, 11017202, 1322173, 2162835, 2162837, 2165491, 2168206, 8231804, 8618822; Product type c : carrier; cytochrome o ubiquinol oxidase subunit II 472332 cyoA 7142103 cyoA Escherichia coli ED1a cytochrome o ubiquinol oxidase subunit II YP_002396507.1 471385 R 585397 CDS YP_002396508.1 218688296 7142102 complement(472792..474267) 1 NC_011745.1 in Escherichia coli this protein is a permease involved in peptidoglycan recycling; member of major facilitator superfamily; MFS; inner membrane protein; muropeptide transporter 474267 ampG 7142102 ampG Escherichia coli ED1a muropeptide transporter YP_002396508.1 472792 R 585397 CDS YP_002396509.1 218688297 7143709 complement(474311..474889) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein 474889 yajG 7143709 yajG Escherichia coli ED1a hypothetical protein YP_002396509.1 474311 R 585397 CDS YP_002396510.1 218688298 7143423 475194..475511 1 NC_011745.1 positive transcriptional regulator of morphogenetic pathway; controlling several genes involved in oxidative stress, acid stress, heat shock, osmotic shock, and carbon-starvation stress; transcriptional regulator BolA 475511 bolA 7143423 bolA Escherichia coli ED1a transcriptional regulator BolA YP_002396510.1 475194 D 585397 CDS YP_002396511.1 218688299 7140461 475445..475708 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 475708 7140461 ECED1_0459 Escherichia coli ED1a hypothetical protein YP_002396511.1 475445 D 585397 CDS YP_002396512.1 218688300 7141841 475855..477153 1 NC_011745.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 477153 tig 7141841 tig Escherichia coli ED1a trigger factor YP_002396512.1 475855 D 585397 CDS YP_002396513.1 218688301 7141557 477399..478022 1 NC_011745.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 478022 clpP 7141557 clpP Escherichia coli ED1a ATP-dependent Clp protease proteolytic subunit YP_002396513.1 477399 D 585397 CDS YP_002396514.1 218688302 7139376 478148..479422 1 NC_011745.1 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 479422 clpX 7139376 clpX Escherichia coli ED1a ATP-dependent protease ATP-binding subunit ClpX YP_002396514.1 478148 D 585397 CDS YP_002396515.1 218688303 7140767 479610..481964 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10094703, 14665623, 8939438, 91072263, 97137085, 2984174, 3042779, 3289547, 7988699, 8226758, 8294008; Product type e : enzyme; DNA-binding ATP-dependent protease La 481964 lon 7140767 lon Escherichia coli ED1a DNA-binding ATP-dependent protease La YP_002396515.1 479610 D 585397 CDS YP_002396516.1 218688304 7141906 482173..482445 1 NC_011745.1 histone-like DNA-binding protein; transcriptional regulator HU subunit beta 482445 hupB 7141906 hupB Escherichia coli ED1a transcriptional regulator HU subunit beta YP_002396516.1 482173 D 585397 CDS YP_002396517.1 218688305 7140179 482637..484508 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9670013; Product type e : enzyme; peptidyl-prolyl cis-trans isomerase D 484508 ppiD 7140179 ppiD Escherichia coli ED1a peptidyl-prolyl cis-trans isomerase D YP_002396517.1 482637 D 585397 CDS YP_002396518.1 218688306 7139106 484659..485030 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 485030 ybaV 7139106 ybaV Escherichia coli ED1a hypothetical protein YP_002396518.1 484659 D 585397 CDS YP_002396519.1 218688307 7138900 485136..485534 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 485534 ybaW 7138900 ybaW Escherichia coli ED1a hypothetical protein YP_002396519.1 485136 D 585397 CDS YP_002396520.1 218688308 7138901 complement(485586..486281) 1 NC_011745.1 YbaX; catalyzes the transformation of GTP to 7-cyano-7-deazaguanine (preQ0), as one of the early reactions of quenosine biosynthesis; quenosine is a modified nucleoside that occurs at the wobble position of GUN anticodons in tRNAs for Asn, Asp, Tyr, and His; queuosine biosynthesis protein QueC 486281 queC 7138901 queC Escherichia coli ED1a queuosine biosynthesis protein QueC YP_002396520.1 485586 R 585397 CDS YP_002396521.1 218688309 7141245 complement(486346..488046) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 488046 ybaE 7141245 ybaE Escherichia coli ED1a hypothetical protein YP_002396521.1 486346 R 585397 CDS YP_002396522.1 218688310 7143431 488146..488964 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15292217; Product type e : enzyme; thiamin pyrimidine pyrophosphate hydrolase 488964 cof 7143431 cof Escherichia coli ED1a thiamin pyrimidine pyrophosphate hydrolase YP_002396522.1 488146 D 585397 CDS YP_002396523.1 218688311 7142038 488889..489575 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator (Lrp-like) 489575 ybaO 7142038 ybaO Escherichia coli ED1a putative DNA-binding transcriptional regulator (Lrp-like) YP_002396523.1 488889 D 585397 CDS YP_002396524.1 218688312 7138895 489605..491377 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 94124004, 10850996; Product type pt : putative transporter; putative multidrug transporter membrane\ATP-binding proteins 491377 mdlA 7138895 mdlA Escherichia coli ED1a putative multidrug transporter membrane\ATP-binding proteins YP_002396524.1 489605 D 585397 CDS YP_002396525.1 218688313 7142220 491370..493151 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 94124004; Product type pt : putative transporter; putative multidrug transporter membrane\ATP-binding proteins 493151 mdlB 7142220 mdlB Escherichia coli ED1a putative multidrug transporter membrane\ATP-binding proteins YP_002396525.1 491370 D 585397 CDS YP_002396526.1 218688314 7142221 493332..493670 1 NC_011745.1 indirectly regulates nitrogen metabolism; at high nitrogen levels P-II 2 prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II 2 is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; functionally it is equivalent to protein P-II (GlnB), but itsexpression is driven by the presence of uridylyltransferase, nitrogen regulator I, and the absence of ammonia.; nitrogen regulatory protein P-II 2 493670 glnK 7142221 glnK Escherichia coli ED1a nitrogen regulatory protein P-II 2 YP_002396526.1 493332 D 585397 CDS YP_002396527.1 218688315 7142959 493700..494986 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 22020597, 9618533, 10931328, 1645722, 7984428; Product type t : transporter; ammonium transporter 494986 amtB 7142959 amtB Escherichia coli ED1a ammonium transporter YP_002396527.1 493700 D 585397 CDS YP_002396528.1 218688316 7142525 complement(495035..495895) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86139906, 91250410, 10876240; Product type e : enzyme; acyl-CoA thioesterase II 495895 tesB 7142525 tesB Escherichia coli ED1a acyl-CoA thioesterase II YP_002396528.1 495035 R 585397 CDS YP_002396529.1 218688317 7141535 496113..496685 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative lipoprotein 496685 ybaY 7141535 ybaY Escherichia coli ED1a putative lipoprotein YP_002396529.1 496113 D 585397 CDS YP_002396530.1 218688318 7138902 complement(496716..497105) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative methylated DNA-protein cysteine alkyltransferase 497105 ybaZ 7138902 ybaZ Escherichia coli ED1a putative methylated DNA-protein cysteine alkyltransferase YP_002396530.1 496716 R 585397 CDS YP_002396531.1 218688319 7144166 497406..497759 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 497759 ybaA 7144166 ybaA Escherichia coli ED1a hypothetical protein YP_002396531.1 497406 D 585397 CDS YP_002396532.1 218688320 7143429 complement(497801..499351) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 499351 ylaB 7143429 ylaB Escherichia coli ED1a hypothetical protein YP_002396532.1 497801 R 585397 CDS YP_002396533.1 218688321 7140957 complement(499515..499985) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 499985 ylaC 7140957 ylaC Escherichia coli ED1a hypothetical protein YP_002396533.1 499515 R 585397 CDS YP_002396534.1 218688322 7140958 complement(500101..500652) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82180540, 91310703, 9600841; Product type e : enzyme; maltose O-acetyltransferase 500652 maa 7140958 maa Escherichia coli ED1a maltose O-acetyltransferase YP_002396534.1 500101 R 585397 CDS YP_002396535.1 218688323 7141939 complement(500825..501043) 1 NC_011745.1 with Hns involved in transcriptional regulation of hemolysin; non-specific DNA-binding protein which affects the production of multiple proteins; hemolysin expression-modulating protein 501043 hha 7141939 hha Escherichia coli ED1a hemolysin expression-modulating protein YP_002396535.1 500825 R 585397 CDS YP_002396536.1 218688324 7139883 complement(501069..501443) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1956303, 7984428, 14645275; hypothetical protein 501443 ybaJ 7139883 ybaJ Escherichia coli ED1a hypothetical protein YP_002396536.1 501069 R 585397 CDS YP_002396537.1 218688325 7143432 complement(501988..505137) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12351840, 12654283, 15111118, 15155734, 21450803, 94012493, 10920254, 7651136; Product type t : transporter; multidrug efflux system protein 505137 acrB 7143432 acrB Escherichia coli ED1a multidrug efflux system protein YP_002396537.1 501988 R 585397 CDS YP_002396538.1 218688326 7143650 complement(505160..506353) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15155734, 21450803, 383699, 390095, 94012493, 10920254, 7651136; Product type t : transporter; multidrug efflux system 506353 acrA 7143650 acrA Escherichia coli ED1a multidrug efflux system YP_002396538.1 505160 R 585397 CDS YP_002396539.1 218688327 7143649 506495..507142 1 NC_011745.1 regulates the acrAB operon which is involved in susceptibility to dephalothin and cephaloridine; DNA-binding transcriptional repressor AcrR 507142 acrR 7143649 acrR Escherichia coli ED1a DNA-binding transcriptional repressor AcrR YP_002396539.1 506495 D 585397 CDS YP_002396540.1 218688328 7143654 507270..510632 1 NC_011745.1 small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS; potassium efflux protein KefA 510632 kefA 7143654 kefA Escherichia coli ED1a potassium efflux protein KefA YP_002396540.1 507270 D 585397 CDS YP_002396541.1 218688329 7142505 complement(510844..511005) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 511005 ybaM 7142505 ybaM Escherichia coli ED1a hypothetical protein YP_002396541.1 510844 R 585397 CDS YP_002396542.1 218688330 7143435 complement(511019..511546) 1 NC_011745.1 PriC; protein involved in DNA replication; part of the primosome, a protein complex required to restart stalled replication forks; binds the complex formed by PriA, PriB and DNA; PriC-dependent primosome requires a gap to restart DNA replication; stimulates Rep activity at stalled forks; primosomal replication protein N'' 511546 priC 7143435 priC Escherichia coli ED1a primosomal replication protein N'' YP_002396542.1 511019 R 585397 CDS YP_002396543.1 218688331 7139121 511616..511993 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 511993 ybaN 7139121 ybaN Escherichia coli ED1a hypothetical protein YP_002396543.1 511616 D 585397 CDS YP_002396544.1 218688332 7138873 512146..512697 1 NC_011745.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 512697 apt 7138873 apt Escherichia coli ED1a adenine phosphoribosyltransferase YP_002396544.1 512146 D 585397 CDS YP_002396545.1 218688333 7142594 512826..514757 1 NC_011745.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 514757 dnaX 7142594 dnaX Escherichia coli ED1a DNA polymerase III subunits gamma and tau YP_002396545.1 512826 D 585397 CDS YP_002396546.1 218688334 7140512 514810..515139 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 15322138, 1698765, 2674903; hypothetical protein 515139 ybaB 7140512 ybaB Escherichia coli ED1a hypothetical protein YP_002396546.1 514810 D 585397 CDS YP_002396547.1 218688335 7143430 515139..515744 1 NC_011745.1 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 515744 recR 7143430 recR Escherichia coli ED1a recombination protein RecR YP_002396547.1 515139 D 585397 CDS YP_002396548.1 218688336 7141584 515854..517728 1 NC_011745.1 molecular chaperone; heat shock protein 90 517728 htpG 7141584 htpG Escherichia coli ED1a heat shock protein 90 YP_002396548.1 515854 D 585397 CDS YP_002396549.1 218688337 7140172 517909..518553 1 NC_011745.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 518553 adk 7140172 adk Escherichia coli ED1a adenylate kinase YP_002396549.1 517909 D 585397 CDS YP_002396550.1 218688338 7143665 518685..519647 1 NC_011745.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 519647 hemH 7143665 hemH Escherichia coli ED1a ferrochelatase YP_002396550.1 518685 D 585397 CDS YP_002396551.1 218688339 7139872 complement(519644..520603) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9401025, 98244813, 2051480, 7721718; Product type e : enzyme; acetyl esterase 520603 aes 7139872 aes Escherichia coli ED1a acetyl esterase YP_002396551.1 519644 R 585397 CDS YP_002396552.1 218688340 7143669 520755..522059 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90155203, 95238302, 2051480; Product type e : enzyme; inosine/guanosine kinase 522059 gsk 7143669 gsk Escherichia coli ED1a inosine/guanosine kinase YP_002396552.1 520755 D 585397 CDS YP_002396553.1 218688341 7143029 complement(522189..523865) 1 NC_011745.1 YbaL; member of the CPA-2 family of antiporters; uncharacterized protein; putative cation:proton antiport protein 523865 ybaL 7143029 ybaL Escherichia coli ED1a putative cation:proton antiport protein YP_002396553.1 522189 R 585397 CDS YP_002396554.1 218688342 7143434 complement(524103..525323) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21450803, 97074653, 8917080; Product type t : transporter; fosmidomycin efflux system protein 525323 fsr 7143434 fsr Escherichia coli ED1a fosmidomycin efflux system protein YP_002396554.1 524103 R 585397 CDS YP_002396555.1 218688343 7142186 525359..525544 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 525544 7142186 ECED1_0503 Escherichia coli ED1a hypothetical protein YP_002396555.1 525359 D 585397 CDS YP_002396556.1 218688344 7141842 525541..527193 1 NC_011745.1 catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides; bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic 527193 ushA 7141842 ushA Escherichia coli ED1a bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic YP_002396556.1 525541 D 585397 CDS YP_002396557.1 218688345 7140150 complement(527230..527709) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 527709 ybaK 7140150 ybaK Escherichia coli ED1a hypothetical protein YP_002396557.1 527230 R 585397 CDS YP_002396558.1 218688346 7140744 complement(527913..528707) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 528707 ybaP 7140744 ybaP Escherichia coli ED1a hypothetical protein YP_002396558.1 527913 R 585397 CDS YP_002396559.1 218688347 7138896 528810..529142 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative RelE/ParE family protein, cytotoxic translational repressor of toxin-antitoxin stability system 529142 7138896 ECED1_0508 Escherichia coli ED1a putative RelE/ParE family protein, cytotoxic translational repressor of toxin-antitoxin stability system YP_002396559.1 528810 D 585397 CDS YP_002396560.1 218688348 7141843 529178..529519 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 529519 ybaQ 7141843 ybaQ Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002396560.1 529178 D 585397 CDS YP_002396561.1 218688349 7138897 complement(529577..532081) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12351646, 20105527, 11167016, 11500054, 9868784; Product type t : transporter; copper exporting ATPase 532081 copA 7138897 copA Escherichia coli ED1a copper exporting ATPase YP_002396561.1 529577 R 585397 CDS YP_002396562.1 218688350 7142039 532343..533275 1 NC_011745.1 catalyzes the formation of glutamate from glutamine; glutaminase 533275 ybaS 7142039 ybaS Escherichia coli ED1a glutaminase YP_002396562.1 532343 D 585397 CDS YP_002396563.1 218688351 7138898 533278..534570 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative nitrogen-containing metabolite transporter 534570 ybaT 7138898 ybaT Escherichia coli ED1a putative nitrogen-containing metabolite transporter YP_002396563.1 533278 D 585397 CDS YP_002396564.1 218688352 7138899 534695..535102 1 NC_011745.1 activator of copper-responsive regulon genes; DNA-binding transcriptional regulator CueR 535102 cueR 7138899 cueR Escherichia coli ED1a DNA-binding transcriptional regulator CueR YP_002396564.1 534695 D 585397 CDS YP_002396565.1 218688353 7142082 complement(535103..536326) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 536326 7142082 ECED1_0514 Escherichia coli ED1a hypothetical protein YP_002396565.1 535103 R 585397 CDS YP_002396566.1 218688354 7141844 complement(536444..536899) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 536899 ybbJ 7141844 ybbJ Escherichia coli ED1a hypothetical protein YP_002396566.1 536444 R 585397 CDS YP_002396567.1 218688355 7138906 complement(536899..537816) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative protease, membrane anchored 537816 ybbK 7138906 ybbK Escherichia coli ED1a putative protease, membrane anchored YP_002396567.1 536899 R 585397 CDS YP_002396568.1 218688356 7138907 537962..538639 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATP-binding protein YbbL 538639 ybbL 7138907 ybbL Escherichia coli ED1a putative ABC transporter ATP-binding protein YbbL YP_002396568.1 537962 D 585397 CDS YP_002396569.1 218688357 7138908 538626..539405 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative permease of an ABC transporter 539405 ybbM 7138908 ybbM Escherichia coli ED1a putative permease of an ABC transporter YP_002396569.1 538626 D 585397 CDS YP_002396570.1 218688358 7138909 complement(539468..540322) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative thioredoxin domain-containing protein 540322 ybbN 7138909 ybbN Escherichia coli ED1a putative thioredoxin domain-containing protein YP_002396570.1 539468 R 585397 CDS YP_002396571.1 218688359 7138910 complement(540383..541192) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; short chain dehydrogenase 541192 ybbO 7138910 ybbO Escherichia coli ED1a short chain dehydrogenase YP_002396571.1 540383 R 585397 CDS YP_002396572.1 218688360 7138911 complement(541182..541808) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91270121, 91324311, 93163029, 93252782, 94179121, 99353977, 1864840, 8432696, 8098033; Product type e : enzyme; multifunctional acyl-CoA thioesterase I/protease I/lysophospholipase L1 541808 tesA 7138911 tesA Escherichia coli ED1a multifunctional acyl-CoA thioesterase I/protease I/lysophospholipase L1 YP_002396572.1 541182 R 585397 CDS YP_002396573.1 218688361 7141534 541776..542462 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATP-binding protein YbbA 542462 ybbA 7141534 ybbA Escherichia coli ED1a putative ABC transporter ATP-binding protein YbbA YP_002396573.1 541776 D 585397 CDS YP_002396574.1 218688362 7138904 542459..544873 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type t : transporter; putative ABC transporter permease 544873 ybbP 7138904 ybbP Escherichia coli ED1a putative ABC transporter permease YP_002396574.1 542459 D 585397 CDS YP_002396575.1 218688363 7138912 complement(545114..546208) 1 NC_011745.1 catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA; tRNA 2-selenouridine synthase 546208 ybbB 7138912 ybbB Escherichia coli ED1a tRNA 2-selenouridine synthase YP_002396575.1 545114 R 585397 CDS YP_002396576.1 218688364 7138905 complement(546277..547203) 1 NC_011745.1 activator of the allDC-ylbA operon involved in allantoin utilization; DNA-binding transcriptional activator AllS 547203 ybbS 7138905 ybbS Escherichia coli ED1a DNA-binding transcriptional activator AllS YP_002396576.1 546277 R 585397 CDS YP_002396577.1 218688365 7138913 547433..547915 1 NC_011745.1 catalyzes the formation of glyoxylate from (S)-ureidoglycolate; ureidoglycolate hydrolase 547915 allA 7138913 allA Escherichia coli ED1a ureidoglycolate hydrolase YP_002396577.1 547433 D 585397 CDS YP_002396578.1 218688366 7143690 547993..548808 1 NC_011745.1 regulates operons involved in the utilization of allantoin; DNA-binding transcriptional repressor AllR 548808 allR 7143690 allR Escherichia coli ED1a DNA-binding transcriptional repressor AllR YP_002396578.1 547993 D 585397 CDS YP_002396579.1 218688367 7143694 548808..550676 1 NC_011745.1 catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate; glyoxylate carboligase 550676 gcl 7143694 gcl Escherichia coli ED1a glyoxylate carboligase YP_002396579.1 548808 D 585397 CDS YP_002396580.1 218688368 7143165 550776..551654 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20069628; Product type e : enzyme; tartronate semialdehyde reductase, NADH-dependent 551654 glxR 7143165 glxR Escherichia coli ED1a tartronate semialdehyde reductase, NADH-dependent YP_002396580.1 550776 D 585397 CDS YP_002396581.1 218688369 7142989 551824..553185 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1293888; Product type t : transporter; allantoin permease 553185 ybbW 7142989 ybbW Escherichia coli ED1a allantoin permease YP_002396581.1 551824 D 585397 CDS YP_002396582.1 218688370 7138914 553338..554699 1 NC_011745.1 Plays a crucial role on both purine and pyrimidine metabolism; allantoinase 554699 allB 7138914 allB Escherichia coli ED1a allantoinase YP_002396582.1 553338 D 585397 CDS YP_002396583.1 218688371 7143691 554755..556056 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative purine permease YbbY 556056 ybbY 7143691 ybbY Escherichia coli ED1a putative purine permease YbbY YP_002396583.1 554755 D 585397 CDS YP_002396584.1 218688372 7138915 556078..557223 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20069628; Product type e : enzyme; glycerate kinase II 557223 glxK 7138915 glxK Escherichia coli ED1a glycerate kinase II YP_002396584.1 556078 D 585397 CDS YP_002396585.1 218688373 7142988 complement(557352..558137) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 558137 ylbA 7142988 ylbA Escherichia coli ED1a hypothetical protein YP_002396585.1 557352 R 585397 CDS YP_002396586.1 218688374 7140959 complement(558148..559383) 1 NC_011745.1 allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide; allantoate amidohydrolase 559383 allC 7140959 allC Escherichia coli ED1a allantoate amidohydrolase YP_002396586.1 558148 R 585397 CDS YP_002396587.1 218688375 7143692 complement(559405..560454) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12460564, 20069628, 69151449; Product type e : enzyme; ureidoglycolate dehydrogenase 560454 allD 7143692 allD Escherichia coli ED1a ureidoglycolate dehydrogenase YP_002396587.1 559405 R 585397 CDS YP_002396588.1 218688376 7143693 560771..562438 1 NC_011745.1 multicopy suppressor of dominant negative ftsH mutations; membrane protein FdrA 562438 fdrA 7143693 fdrA Escherichia coli ED1a membrane protein FdrA YP_002396588.1 560771 D 585397 CDS YP_002396589.1 218688377 7144145 562448..563707 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 563707 ylbE 7144145 ylbE Escherichia coli ED1a hypothetical protein YP_002396589.1 562448 D 585397 CDS YP_002396590.1 218688378 7140960 563718..564533 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 564533 ylbF 7140960 ylbF Escherichia coli ED1a hypothetical protein YP_002396590.1 563718 D 585397 CDS YP_002396591.1 218688379 7140961 564530..565423 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2464576, 2644189, 7920643, 7940673, 7984428; Product type pe : putative enzyme; carbamate kinase 565423 ybcF 7140961 ybcF Escherichia coli ED1a carbamate kinase YP_002396591.1 564530 D 585397 CDS YP_002396592.1 218688380 7138916 complement(565956..567023) 1 NC_011745.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 567023 purK 7138916 purK Escherichia coli ED1a phosphoribosylaminoimidazole carboxylase ATPase subunit YP_002396592.1 565956 R 585397 CDS YP_002396593.1 218688381 7141220 complement(567020..567529) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10074353, 8117684, 89123018, 89123019, 92287929, 10574791; Product type e : enzyme; N5-carboxyaminoimidazole ribonucleotide mutase 567529 purE 7141220 purE Escherichia coli ED1a N5-carboxyaminoimidazole ribonucleotide mutase YP_002396593.1 567020 R 585397 CDS YP_002396594.1 218688382 7141217 complement(567625..567954) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 567954 7141217 ECED1_0543 Escherichia coli ED1a hypothetical protein YP_002396594.1 567625 R 585397 CDS YP_002396595.1 218688383 7141845 complement(568065..568787) 1 NC_011745.1 catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine; UDP-2,3-diacylglucosamine hydrolase 568787 lpxH 7141845 lpxH Escherichia coli ED1a UDP-2,3-diacylglucosamine hydrolase YP_002396595.1 568065 R 585397 CDS YP_002396596.1 218688384 7141921 complement(568790..569284) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90272647, 91175755, 1606970, 1864365, 8601841, 9298646, 9600841; Product type e : enzyme; peptidyl-prolyl cis-trans isomerase B 569284 ppiB 7141921 ppiB Escherichia coli ED1a peptidyl-prolyl cis-trans isomerase B YP_002396596.1 568790 R 585397 CDS YP_002396597.1 218688385 7139104 569458..570843 1 NC_011745.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 570843 cysS 7139104 cysS Escherichia coli ED1a cysteinyl-tRNA synthetase YP_002396597.1 569458 D 585397 CDS YP_002396598.1 218688386 7143045 complement(570879..571400) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 571400 ybcI 7143045 ybcI Escherichia coli ED1a hypothetical protein YP_002396598.1 570879 R 585397 CDS YP_002396599.1 218688387 7138918 complement(571508..571720) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12837795, 1748668, 7567469; Product type pr : putative regulator; hypothetical protein 571720 ybcJ 7138918 ybcJ Escherichia coli ED1a hypothetical protein YP_002396599.1 571508 R 585397 CDS YP_002396600.1 218688388 7138919 complement(571722..572588) 1 NC_011745.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 572588 folD 7138919 folD Escherichia coli ED1a bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase YP_002396600.1 571722 R 585397 CDS YP_002396601.1 218688389 7142158 572638..572826 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 572826 7142158 ECED1_0550 Escherichia coli ED1a hypothetical protein YP_002396601.1 572638 D 585397 CDS YP_002396602.1 218688390 7142442 573577..573933 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail fiber assembly protein 573933 tfaQ 7142442 tfaQ Escherichia coli ED1a tail fiber assembly protein YP_002396602.1 573577 D 585397 CDS YP_002396603.1 218688391 7141537 complement(573988..574572) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative AdoMet-dependent methyltransferase; DLP12 prophage 574572 ybcY 7141537 ybcY Escherichia coli ED1a putative AdoMet-dependent methyltransferase; DLP12 prophage YP_002396603.1 573988 R 585397 CDS YP_002396604.1 218688392 7138922 complement(575113..575616) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12770720, 6265806; Product type h : extrachromosomal origin; Insertion element IS1 1/5/6 protein insB 575616 insB 7138922 insB Escherichia coli ED1a Insertion element IS1 1/5/6 protein insB YP_002396604.1 575113 R 585397 CDS YP_002396605.1 218688393 7141138 complement(575535..575810) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 575810 insA 7141138 insA Escherichia coli ED1a IS1 repressor protein InsA YP_002396605.1 575535 R 585397 CDS YP_002396606.1 218688394 7139975 complement(577276..578166) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 578166 ybcH 7139975 ybcH Escherichia coli ED1a hypothetical protein YP_002396606.1 577276 R 585397 CDS YP_002396607.1 218688395 7138917 complement(578167..581139) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89359086, 94042873, 94042874; Product type m : membrane component; bacteriophage N4 receptor, outer membrane subunit 581139 nfrA 7138917 nfrA Escherichia coli ED1a bacteriophage N4 receptor, outer membrane subunit YP_002396607.1 578167 R 585397 CDS YP_002396608.1 218688396 7140380 complement(583513..584955) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20461235, 11283292, 11399769; Product type r : regulator; sensor kinase CusS 584955 cusS 7140380 cusS Escherichia coli ED1a sensor kinase CusS YP_002396608.1 583513 R 585397 CDS YP_002396609.1 218688397 7142088 complement(584945..585628) 1 NC_011745.1 response regulator in two-component regulatory system with CusS; regulates the copper efflux system; DNA-binding transcriptional activator CusR 585628 cusR 7142088 cusR Escherichia coli ED1a DNA-binding transcriptional activator CusR YP_002396609.1 584945 R 585397 CDS YP_002396610.1 218688398 7142087 585785..587167 1 NC_011745.1 with CusA, CusB and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system outer membrane protein CusC 587167 cusC 7142087 cusC Escherichia coli ED1a copper/silver efflux system outer membrane protein CusC YP_002396610.1 585785 D 585397 CDS YP_002396611.1 218688399 7142085 587191..587523 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 21125583, 11283292, 11399769, 12813074; Product type f : factor; periplasmic copper-binding protein 587523 cusF 7142085 cusF Escherichia coli ED1a periplasmic copper-binding protein YP_002396611.1 587191 D 585397 CDS YP_002396612.1 218688400 7142086 587539..588762 1 NC_011745.1 with CusA, CusC and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system membrane fusion protein CusB 588762 cusB 7142086 cusB Escherichia coli ED1a copper/silver efflux system membrane fusion protein CusB YP_002396612.1 587539 D 585397 CDS YP_002396613.1 218688401 7142084 588774..591917 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20461235, 21125583, 21178899, 21450803, 11399769, 12813074, 1711024, 7984428; Product type t : transporter; copper/silver efflux system, membrane component 591917 cusA 7142084 cusA Escherichia coli ED1a copper/silver efflux system, membrane component YP_002396613.1 588774 D 585397 CDS YP_002396614.1 218688402 7142083 591983..593401 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91267923, 94042931, 8626334; Product type t : transporter; phenylalanine transporter 593401 pheP 7142083 pheP Escherichia coli ED1a phenylalanine transporter YP_002396614.1 591983 D 585397 CDS YP_002396615.1 218688403 7144084 complement(593558..594805) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative channel membrane protein 594805 ybdG 7144084 ybdG Escherichia coli ED1a putative channel membrane protein YP_002396615.1 593558 R 585397 CDS YP_002396616.1 218688404 7138927 complement(594913..595566) 1 NC_011745.1 catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive; dihydropteridine reductase 595566 nfnB 7138927 nfnB Escherichia coli ED1a dihydropteridine reductase YP_002396616.1 594913 R 585397 CDS YP_002396617.1 218688405 7140376 complement(595645..596013) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 596013 ybdF 7140376 ybdF Escherichia coli ED1a hypothetical protein YP_002396617.1 595645 R 585397 CDS YP_002396618.1 218688406 7138926 complement(596093..596341) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 596341 ybdJ 7138926 ybdJ Escherichia coli ED1a hypothetical protein YP_002396618.1 596093 R 585397 CDS YP_002396619.1 218688407 7138929 complement(596407..597525) 1 NC_011745.1 ATP-dependent; carboxylate-amine ligase with weak glutamate--cysteine ligase activity; carboxylate-amine ligase 597525 ybdK 7138929 ybdK Escherichia coli ED1a carboxylate-amine ligase YP_002396619.1 596407 R 585397 CDS YP_002396620.1 218688408 7138930 597979..598131 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99291074; Product type f : factor; toxic polypeptide, small 598131 hokE 7138930 hokE Escherichia coli ED1a toxic polypeptide, small YP_002396620.1 597979 D 585397 CDS YP_002396621.1 218688409 7139909 complement(598253..598882) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89313305, 90132534, 91035252, 8939709, 9214294; Product type e : enzyme; phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex 598882 entD 7139909 entD Escherichia coli ED1a phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex YP_002396621.1 598253 R 585397 CDS YP_002396622.1 218688410 7144157 601609..602733 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92291125, 94198561, 2974033; Product type e : enzyme; enterobactin/ferric enterobactin esterase 602733 fes 7144157 fes Escherichia coli ED1a enterobactin/ferric enterobactin esterase YP_002396622.1 601609 D 585397 CDS YP_002396623.1 218688411 7144164 602736..602954 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 602954 ybdZ 7144164 ybdZ Escherichia coli ED1a hypothetical protein YP_002396623.1 602736 D 585397 CDS YP_002396624.1 218688412 7138933 602951..606832 1 NC_011745.1 with EntB, EntD, and EntE forms the multienzyme complex enterobactin synthase; EntF is the serine activating enzyme which catalyzes the formation of the amide and ester bonds of the cyclic enterobactin; enterobactin synthase subunit F 606832 entF 7138933 entF Escherichia coli ED1a enterobactin synthase subunit F YP_002396624.1 602951 D 585397 CDS YP_002396625.1 218688413 7144161 607209..608213 1 NC_011745.1 part of the ferric enterobactin transport system; necessary for enetrobactin uptake; ferric enterobactin transport protein FepE 608213 fepE 7144161 fepE Escherichia coli ED1a ferric enterobactin transport protein FepE YP_002396625.1 607209 D 585397 CDS YP_002396626.1 218688414 7144162 complement(608210..609025) 1 NC_011745.1 with FepBDE is involved in the transport of ferric enterobactin; iron-enterobactin transporter ATP-binding protein 609025 fepC 7144162 fepC Escherichia coli ED1a iron-enterobactin transporter ATP-binding protein YP_002396626.1 608210 R 585397 CDS YP_002396627.1 218688415 7144159 complement(609022..610014) 1 NC_011745.1 with FepBCD is involved in the transport of ferric enterobactin; iron-enterobactin transporter permease 610014 fepG 7144159 fepG Escherichia coli ED1a iron-enterobactin transporter permease YP_002396627.1 609022 R 585397 CDS YP_002396628.1 218688416 7144163 complement(610011..611015) 1 NC_011745.1 with FepBCG is involved in the transport of ferric enterobactin; iron-enterobactin transporter membrane protein 611015 fepD 7144163 fepD Escherichia coli ED1a iron-enterobactin transporter membrane protein YP_002396628.1 610011 R 585397 CDS YP_002396629.1 218688417 7144160 611126..612376 1 NC_011745.1 protein p43; inner membrane protein that exports enterobactin to the periplasmic space; member of the major facilitator superfamily (MFS) of transporters; enterobactin exporter EntS 612376 ybdA 7144160 ybdA Escherichia coli ED1a enterobactin exporter EntS YP_002396629.1 611126 D 585397 CDS YP_002396630.1 218688418 7138923 complement(612380..613336) 1 NC_011745.1 with FepCDG is involved in the transport of ferric enterobactin; iron-enterobactin transporter periplasmic binding protein 613336 fepB 7138923 fepB Escherichia coli ED1a iron-enterobactin transporter periplasmic binding protein YP_002396630.1 612380 R 585397 CDS YP_002396631.1 218688419 7144158 613525..614700 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89123153, 90165423, 90241936, 2110093, 2139473; Product type e : enzyme; isochorismate synthase 1 614700 entC 7144158 entC Escherichia coli ED1a isochorismate synthase 1 YP_002396631.1 613525 D 585397 CDS YP_002396632.1 218688420 7139796 614710..616320 1 NC_011745.1 bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate; enterobactin synthase subunit E 616320 entE 7139796 entE Escherichia coli ED1a enterobactin synthase subunit E YP_002396632.1 614710 D 585397 CDS YP_002396633.1 218688421 7139798 616334..617191 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20183918, 90241937, 91035252, 9485415, 97361959, 2521621, 2521622; Product type e : enzyme; isochorismatase 617191 entB 7139798 entB Escherichia coli ED1a isochorismatase YP_002396633.1 616334 D 585397 CDS YP_002396634.1 218688422 7139795 617191..617937 1 NC_011745.1 catalyzes the formation of 2,3-dihydroxybenzoate from 2,3-dihydro-2,3-dihydroxybenzoate; involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin; 2,3-dihydroxybenzoate-2,3-dehydrogenase 617937 entA 7139795 entA Escherichia coli ED1a 2,3-dihydroxybenzoate-2,3-dehydrogenase YP_002396634.1 617191 D 585397 CDS YP_002396635.1 218688423 7139794 617940..618353 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2521621, 2521622, 15808744; Product type pe : putative enzyme; hypothetical protein 618353 ybdB 7139794 ybdB Escherichia coli ED1a hypothetical protein YP_002396635.1 617940 D 585397 CDS YP_002396636.1 218688424 7142080 620741..620938 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 620938 ybdD 7142080 ybdD Escherichia coli ED1a hypothetical protein YP_002396636.1 620741 D 585397 CDS YP_002396637.1 218688425 7138925 complement(620948..622036) 1 NC_011745.1 member of the iron-containing alcohol dehydrogenase family; unknown function; hypothetical protein 622036 ybdH 7138925 ybdH Escherichia coli ED1a hypothetical protein YP_002396637.1 620948 R 585397 CDS YP_002396638.1 218688426 7138928 622145..623305 1 NC_011745.1 catalyzes the transfer of an amino moiety; putative aminotransferase 623305 ybdL 7138928 ybdL Escherichia coli ED1a putative aminotransferase YP_002396638.1 622145 D 585397 CDS YP_002396639.1 218688427 7138931 complement(623306..623935) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12057959; Product type r : regulator; immunoglobulin-binding regulator 623935 ibrB 7138931 ibrB Escherichia coli ED1a immunoglobulin-binding regulator YP_002396639.1 623306 R 585397 CDS YP_002396640.1 218688428 7140219 complement(623908..625128) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12057959; Product type r : regulator; immunoglobulin-binding regulator 625128 ibrA 7140219 ibrA Escherichia coli ED1a immunoglobulin-binding regulator YP_002396640.1 623908 R 585397 CDS YP_002396641.1 218688429 7140217 complement(625275..626213) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative LysR-type DNA-binding transcriptional regulator 626213 ybdO 7140217 ybdO Escherichia coli ED1a putative LysR-type DNA-binding transcriptional regulator YP_002396641.1 625275 R 585397 CDS YP_002396642.1 218688430 7138932 complement(626382..627128) 1 NC_011745.1 Involved in disulfide bond formation; disulfide isomerase/thiol-disulfide oxidase 627128 dsbG 7138932 dsbG Escherichia coli ED1a disulfide isomerase/thiol-disulfide oxidase YP_002396642.1 626382 R 585397 CDS YP_002396643.1 218688431 7140524 627500..628063 1 NC_011745.1 with AhpF catalyzes the conversion of alkyl hydroperoxides to their corresponding alcohols; AhpC reduced the hydroperoxide substrate; alkyl hydroperoxide reductase subunit C 628063 ahpC 7140524 ahpC Escherichia coli ED1a alkyl hydroperoxide reductase subunit C YP_002396643.1 627500 D 585397 CDS YP_002396644.1 218688432 7143681 628234..629799 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89197774, 1592833; Product type e : enzyme; alkyl hydroperoxide reductase F52a subunit 629799 ahpF 7143681 ahpF Escherichia coli ED1a alkyl hydroperoxide reductase F52a subunit YP_002396644.1 628234 D 585397 CDS YP_002396645.1 218688433 7143682 complement(629920..630348) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12732303, 12071968; Product type f : factor; universal stress protein UP12 630348 uspG 7143682 uspG Escherichia coli ED1a universal stress protein UP12 YP_002396645.1 629920 R 585397 CDS YP_002396646.1 218688434 7139148 complement(630705..631115) 1 NC_011745.1 Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation; nucleoside diphosphate kinase regulator 631115 rnk 7139148 rnk Escherichia coli ED1a nucleoside diphosphate kinase regulator YP_002396646.1 630705 R 585397 CDS YP_002396647.1 218688435 7141439 complement(631345..632151) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90151658, 90264307, 2253883, 8188249; Product type e : enzyme; ribonuclease I 632151 rna 7141439 rna Escherichia coli ED1a ribonuclease I YP_002396647.1 631345 R 585397 CDS YP_002396648.1 218688436 7141430 complement(632265..633728) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9696764; Product type t : transporter; citrate:succinate antiporter 633728 citT 7141430 citT Escherichia coli ED1a citrate:succinate antiporter YP_002396648.1 632265 R 585397 CDS YP_002396649.1 218688437 7139366 complement(633779..634657) 1 NC_011745.1 catalyzes the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA from ATP and 3-dephospho-CoA; triphosphoribosyl-dephospho-CoA synthase 634657 citG 7139366 citG Escherichia coli ED1a triphosphoribosyl-dephospho-CoA synthase YP_002396649.1 633779 R 585397 CDS YP_002396650.1 218688438 7139365 complement(634632..635183) 1 NC_011745.1 2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase; holo-citrate lyase synthase; CitG forms the prosthetic group precursor 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA which is then transferred to apo-ACP by CitX to produce holo-ACP and pyrophosphate; 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo- citrate lyase 635183 citX 7139365 citX Escherichia coli ED1a 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo- citrate lyase YP_002396650.1 634632 R 585397 CDS YP_002396651.1 218688439 7139367 complement(635187..636719) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 84024606, 87214225; Product type e : enzyme; citrate lyase, citrate-ACP transferase subunit alpha 636719 citF 7139367 citF Escherichia coli ED1a citrate lyase, citrate-ACP transferase subunit alpha YP_002396651.1 635187 R 585397 CDS YP_002396652.1 218688440 7139364 complement(636730..637638) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 84024606, 87214225; Product type e : enzyme; citrate lyase, citryl-ACP lyase subunit beta 637638 citE 7139364 citE Escherichia coli ED1a citrate lyase, citryl-ACP lyase subunit beta YP_002396652.1 636730 R 585397 CDS YP_002396653.1 218688441 7139363 complement(637635..637931) 1 NC_011745.1 acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate; citrate lyase subunit gamma 637931 citD 7139363 citD Escherichia coli ED1a citrate lyase subunit gamma YP_002396653.1 637635 R 585397 CDS YP_002396654.1 218688442 7139362 complement(637946..639004) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 84024606, 87214225; Product type e : enzyme; citrate lyase synthetase 639004 citC 7139362 citC Escherichia coli ED1a citrate lyase synthetase YP_002396654.1 637946 R 585397 CDS YP_002396655.1 218688443 7139361 639384..641042 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11889485, 21885746, 9701802; Product type r : regulator; sensory histidine kinase in two-component regulatory system with citB 641042 citA 7139361 citA Escherichia coli ED1a sensory histidine kinase in two-component regulatory system with citB YP_002396655.1 639384 D 585397 CDS YP_002396656.1 218688444 7139359 641011..641691 1 NC_011745.1 regulates the expression of citAB in citrate fermentation; two-component response regulator DpiA 641691 dpiA 7139359 dpiA Escherichia coli ED1a two-component response regulator DpiA YP_002396656.1 641011 D 585397 CDS YP_002396657.1 218688445 7139360 complement(641732..643117) 1 NC_011745.1 responsible for the transport of C4-dicarboxylates during anaerobic growth; C4-dicarboxylate transporter DcuC 643117 dcuC 7139360 dcuC Escherichia coli ED1a C4-dicarboxylate transporter DcuC YP_002396657.1 641732 R 585397 CDS YP_002396658.1 218688446 7143076 643704..644264 1 NC_011745.1 catalyzes the transfer of palmitate to lipid A; palmitoyl transferase 644264 pagP 7143076 pagP Escherichia coli ED1a palmitoyl transferase YP_002396658.1 643704 D 585397 CDS YP_002396659.1 218688447 7142048 644439..644648 1 NC_011745.1 member of the CspA family; constitutively expressed RNA/ssDNA-binding protein; functions in helping cells adapt to low temperature; aids nucleic acid melting; participates in gene regulation; can act as a transcription antiterminator; cold shock protein CspE 644648 cspE 7142048 cspE Escherichia coli ED1a cold shock protein CspE YP_002396659.1 644439 D 585397 CDS YP_002396660.1 218688448 7142072 complement(644702..645085) 1 NC_011745.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 645085 crcB 7142072 crcB Escherichia coli ED1a camphor resistance protein CrcB YP_002396660.1 644702 R 585397 CDS YP_002396661.1 218688449 7142049 645403..645966 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative amidase 645966 ybeM 7142049 ybeM Escherichia coli ED1a putative amidase YP_002396661.1 645403 D 585397 CDS YP_002396662.1 218688450 7138938 646095..646298 1 NC_011745.1 TatE; similar to TatA and found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase protein E 646298 tatE 7138938 tatE Escherichia coli ED1a twin arginine translocase protein E YP_002396662.1 646095 D 585397 CDS YP_002396663.1 218688451 7141516 complement(646398..647363) 1 NC_011745.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 647363 lipA 7141516 lipA Escherichia coli ED1a lipoyl synthase YP_002396663.1 646398 R 585397 CDS YP_002396664.1 218688452 7141888 complement(647595..647924) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 647924 7141888 ECED1_0625 Escherichia coli ED1a hypothetical protein YP_002396664.1 647595 R 585397 CDS YP_002396665.1 218688453 7141847 complement(648183..648824) 1 NC_011745.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B 648824 lipB 7141847 lipB Escherichia coli ED1a lipoate-protein ligase B YP_002396665.1 648183 R 585397 CDS YP_002396666.1 218688454 7141889 complement(648925..649188) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8444795; hypothetical protein 649188 ybeD 7141889 ybeD Escherichia coli ED1a hypothetical protein YP_002396666.1 648925 R 585397 CDS YP_002396667.1 218688455 7138936 complement(649298..650509) 1 NC_011745.1 penicillin-binding protein 5; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; D-alanyl-D-alanine carboxypeptidase fraction A 650509 dacA 7138936 dacA Escherichia coli ED1a D-alanyl-D-alanine carboxypeptidase fraction A YP_002396667.1 649298 R 585397 CDS YP_002396668.1 218688456 7143052 complement(650649..651737) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88058785, 2644207; Product type lp : lipoprotein; rare lipoprotein A 651737 rlpA 7143052 rlpA Escherichia coli ED1a rare lipoprotein A YP_002396668.1 650649 R 585397 CDS YP_002396669.1 218688457 7141422 complement(651748..652860) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89123070, 90036736, 91072213, 3316191; Product type cp : cell process; cell wall shape-determining protein 652860 mrdB 7141422 mrdB Escherichia coli ED1a cell wall shape-determining protein YP_002396669.1 651748 R 585397 CDS YP_002396670.1 218688458 7139025 complement(652863..654764) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86196149, 87030266, 89174517, 2644207; Product type e : enzyme; penicillin-binding protein 2 654764 mrdA 7139025 mrdA Escherichia coli ED1a penicillin-binding protein 2 YP_002396670.1 652863 R 585397 CDS YP_002396671.1 218688459 7139024 complement(654795..655262) 1 NC_011745.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase 655262 ybeA 7139024 ybeA Escherichia coli ED1a rRNA large subunit methyltransferase YP_002396671.1 654795 R 585397 CDS YP_002396672.1 218688460 7138934 complement(655266..655583) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 655583 ybeB 7138934 ybeB Escherichia coli ED1a hypothetical protein YP_002396672.1 655266 R 585397 CDS YP_002396673.1 218688461 7138935 complement(655843..656454) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7929373; Product type pe : putative enzyme; putative phosphatase with phosphoglycerate mutase domain 656454 phpB 7138935 phpB Escherichia coli ED1a putative phosphatase with phosphoglycerate mutase domain YP_002396673.1 655843 R 585397 CDS YP_002396674.1 218688462 7144111 complement(656478..657119) 1 NC_011745.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase 657119 nadD 7144111 nadD Escherichia coli ED1a nicotinic acid mononucleotide adenylyltransferase YP_002396674.1 656478 R 585397 CDS YP_002396675.1 218688463 7140333 complement(657121..658152) 1 NC_011745.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 658152 holA 7140333 holA Escherichia coli ED1a DNA polymerase III subunit delta YP_002396675.1 657121 R 585397 CDS YP_002396676.1 218688464 7139910 complement(658152..658733) 1 NC_011745.1 rare lipoprotein B; involved in the assembly of LPS in the outer membrane; LPS-assembly lipoprotein RlpB 658733 rlpB 7139910 rlpB Escherichia coli ED1a LPS-assembly lipoprotein RlpB YP_002396676.1 658152 R 585397 CDS YP_002396677.1 218688465 7141423 complement(658748..661330) 1 NC_011745.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 661330 leuS 7141423 leuS Escherichia coli ED1a leucyl-tRNA synthetase YP_002396677.1 658748 R 585397 CDS YP_002396678.1 218688466 7141882 661565..662047 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11373298, 12105207, 3320963, 7567469; hypothetical protein 662047 ybeL 7141882 ybeL Escherichia coli ED1a hypothetical protein YP_002396678.1 661565 D 585397 CDS YP_002396679.1 218688467 7138937 complement(662092..663027) 1 NC_011745.1 Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively; pyrimidine-specific; ribonucleoside hydrolase 1 663027 rihA 7138937 rihA Escherichia coli ED1a ribonucleoside hydrolase 1 YP_002396679.1 662092 R 585397 CDS YP_002396680.1 218688468 7141413 complement(663145..663870) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11121068; Product type t : transporter; glutamate and aspartate ABC transporter ATP-binding protein 663870 gltL 7141413 gltL Escherichia coli ED1a glutamate and aspartate ABC transporter ATP-binding protein YP_002396680.1 663145 R 585397 CDS YP_002396681.1 218688469 7142984 complement(663870..664544) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11121068; Product type t : transporter; glutamate and aspartate ABC transporter membrane protein 664544 gltK 7142984 gltK Escherichia coli ED1a glutamate and aspartate ABC transporter membrane protein YP_002396681.1 663870 R 585397 CDS YP_002396682.1 218688470 7142983 complement(664544..665284) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11121068; Product type t : transporter; glutamate and aspartate ABC transporter membrane protein 665284 gltJ 7142983 gltJ Escherichia coli ED1a glutamate and aspartate ABC transporter membrane protein YP_002396682.1 664544 R 585397 CDS YP_002396683.1 218688471 7140745 complement(665454..666362) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1091636, 1091635, 10493123, 8740179, 10972807; Product type t : transporter; glutamate and aspartate transporter subunit 666362 gltI 7140745 gltI Escherichia coli ED1a glutamate and aspartate transporter subunit YP_002396683.1 665454 R 585397 CDS YP_002396684.1 218688472 7142981 666816..668693 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 668693 7142981 ECED1_0646 Escherichia coli ED1a hypothetical protein YP_002396684.1 666816 D 585397 CDS YP_002396685.1 218688473 7141848 668629..668823 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 668823 7141848 ECED1_0647 Escherichia coli ED1a hypothetical protein YP_002396685.1 668629 D 585397 CDS YP_002396686.1 218688474 7141849 complement(668820..670358) 1 NC_011745.1 Transfers the fatty acyl group on membrane lipoproteins; apolipoprotein N-acyltransferase 670358 lnt 7141849 lnt Escherichia coli ED1a apolipoprotein N-acyltransferase YP_002396686.1 668820 R 585397 CDS YP_002396687.1 218688475 7141899 complement(670383..671261) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1779764; Product type pt : putative transporter; putative divalent ion export protein 671261 ybeX 7141899 ybeX Escherichia coli ED1a putative divalent ion export protein YP_002396687.1 670383 R 585397 CDS YP_002396688.1 218688476 7138939 complement(671351..671818) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16511207; Product type pe : putative enzyme; putative metalloprotease 671818 ybeY 7138939 ybeY Escherichia coli ED1a putative metalloprotease YP_002396688.1 671351 R 585397 CDS YP_002396689.1 218688477 7138940 complement(671815..672894) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12762842; Product type pe : putative enzyme; putative enzyme with nucleoside triphosphate hydrolase domain 672894 ybeZ 7138940 ybeZ Escherichia coli ED1a putative enzyme with nucleoside triphosphate hydrolase domain YP_002396689.1 671815 R 585397 CDS YP_002396690.1 218688478 7138941 complement(673008..674432) 1 NC_011745.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase 674432 miaB 7138941 miaB Escherichia coli ED1a (dimethylallyl)adenosine tRNA methylthiotransferase YP_002396690.1 673008 R 585397 CDS YP_002396691.1 218688479 7138980 674578..675753 1 NC_011745.1 catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol; functions in the biosynthesis of ubiquinone or coenzyme Q; 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase 675753 ubiF 7138980 ubiF Escherichia coli ED1a 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase YP_002396691.1 674578 D 585397 CDS YP_002396692.1 218688480 7140633 complement(676993..678657) 1 NC_011745.1 functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP; asparagine synthetase B 678657 asnB 7140633 asnB Escherichia coli ED1a asparagine synthetase B YP_002396692.1 676993 R 585397 CDS YP_002396693.1 218688481 7142646 complement(678913..679665) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16430214, 89343637; Product type e : enzyme; UMP phosphatase 679665 nagD 7142646 nagD Escherichia coli ED1a UMP phosphatase YP_002396693.1 678913 R 585397 CDS YP_002396694.1 218688482 7140339 complement(679713..680933) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15066032, 90136533, 91171292, 92114782, 92356048, 2190615, 2668691, 7545108; Product type r : regulator; DNA-binding transcriptional dual regulator, repressor of N-acetylglucosamine 680933 nagC 7140339 nagC Escherichia coli ED1a DNA-binding transcriptional dual regulator, repressor of N-acetylglucosamine YP_002396694.1 679713 R 585397 CDS YP_002396695.1 218688483 7140338 complement(680942..682090) 1 NC_011745.1 catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate; N-acetylglucosamine-6-phosphate deacetylase 682090 nagA 7140338 nagA Escherichia coli ED1a N-acetylglucosamine-6-phosphate deacetylase YP_002396695.1 680942 R 585397 CDS YP_002396696.1 218688484 7140336 complement(682150..682950) 1 NC_011745.1 catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate; glucosamine-6-phosphate deaminase 682950 nagB 7140336 nagB Escherichia coli ED1a glucosamine-6-phosphate deaminase YP_002396696.1 682150 R 585397 CDS YP_002396697.1 218688485 7140337 683283..685229 1 NC_011745.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system N-acetyl glucosamine specific transporter subunits IIABC 685229 nagE 7140337 nagE Escherichia coli ED1a PTS system N-acetyl glucosamine specific transporter subunits IIABC YP_002396697.1 683283 D 585397 CDS YP_002396698.1 218688486 7140340 685432..687096 1 NC_011745.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glutaminyl-tRNA synthetase 687096 glnS 7140340 glnS Escherichia coli ED1a glutaminyl-tRNA synthetase YP_002396698.1 685432 D 585397 CDS YP_002396699.1 218688487 7142963 687538..688944 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2118530, 9636669; Product type pt : putative transporter; putative outer membrane porin 688944 ybfM 7142963 ybfM Escherichia coli ED1a putative outer membrane porin YP_002396699.1 687538 D 585397 CDS YP_002396700.1 218688488 7138945 688994..689320 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; putative lipoprotein 689320 ybfN 7138945 ybfN Escherichia coli ED1a putative lipoprotein YP_002396700.1 688994 D 585397 CDS YP_002396701.1 218688489 7138946 complement(689404..689850) 1 NC_011745.1 negatively regulates a number of operons that encode enzymes involved in iron transport; activated by manganese; forms a homodimer; ferric uptake regulator 689850 fur 7138946 fur Escherichia coli ED1a ferric uptake regulator YP_002396701.1 689404 R 585397 CDS YP_002396702.1 218688490 7143134 689895..690149 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 690149 7143134 ECED1_0665 Escherichia coli ED1a hypothetical protein YP_002396702.1 689895 D 585397 CDS YP_002396703.1 218688491 7141850 complement(690139..690669) 1 NC_011745.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin FldA 690669 fldA 7141850 fldA Escherichia coli ED1a flavodoxin FldA YP_002396703.1 690139 R 585397 CDS YP_002396704.1 218688492 7144196 complement(690809..691102) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20223640, 12427949; Product type cp : cell process; LexA regulated protein 691102 ybfE 7144196 ybfE Escherichia coli ED1a LexA regulated protein YP_002396704.1 690809 R 585397 CDS YP_002396705.1 218688493 7138943 complement(691242..692006) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15808744; Product type pe : putative enzyme; hypothetical protein 692006 ybfF 7138943 ybfF Escherichia coli ED1a hypothetical protein YP_002396705.1 691242 R 585397 CDS YP_002396706.1 218688494 7138944 692191..692736 1 NC_011745.1 negative modulator of the initiation of chromosome replication; replication initiation regulator SeqA 692736 seqA 7138944 seqA Escherichia coli ED1a replication initiation regulator SeqA YP_002396706.1 692191 D 585397 CDS YP_002396707.1 218688495 7141396 692762..694402 1 NC_011745.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase 694402 pgm 7141396 pgm Escherichia coli ED1a phosphoglucomutase YP_002396707.1 692762 D 585397 CDS YP_002396708.1 218688496 7144077 complement(694459..695778) 1 NC_011745.1 catalyzes the uptake of putrescine via a proton symport mechanism, as well as the efflux of putrescine by a putrescine/ornithine antiport system; putrescine transporter 695778 potE 7144077 potE Escherichia coli ED1a putrescine transporter YP_002396708.1 694459 R 585397 CDS YP_002396709.1 218688497 7139087 complement(695775..697973) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92041955; Product type e : enzyme; ornithine decarboxylase 697973 speF 7139087 speF Escherichia coli ED1a ornithine decarboxylase YP_002396709.1 695775 R 585397 CDS YP_002396710.1 218688498 7143828 complement(698662..699339) 1 NC_011745.1 response regulator in two-component regulatory system with KdpD; regulates the kdp operon involved in potassium transport; DNA-binding transcriptional activator KdpE 699339 kdpE 7143828 kdpE Escherichia coli ED1a DNA-binding transcriptional activator KdpE YP_002396710.1 698662 R 585397 CDS YP_002396711.1 218688499 7142497 complement(699336..702020) 1 NC_011745.1 sensory histidine kinase in two-component regulatory system with KdpE; signal sensing protein; sensor protein KdpD 702020 kdpD 7142497 kdpD Escherichia coli ED1a sensor protein KdpD YP_002396711.1 699336 R 585397 CDS YP_002396712.1 218688500 7142496 complement(702013..702585) 1 NC_011745.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex; potassium-transporting ATPase subunit C 702585 kdpC 7142496 kdpC Escherichia coli ED1a potassium-transporting ATPase subunit C YP_002396712.1 702013 R 585397 CDS YP_002396713.1 218688501 7142495 complement(702594..704642) 1 NC_011745.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit B 704642 kdpB 7142495 kdpB Escherichia coli ED1a potassium-transporting ATPase subunit B YP_002396713.1 702594 R 585397 CDS YP_002396714.1 218688502 7142494 complement(704665..706338) 1 NC_011745.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit A 706338 kdpA 7142494 kdpA Escherichia coli ED1a potassium-transporting ATPase subunit A YP_002396714.1 704665 R 585397 CDS YP_002396715.1 218688503 7142493 706740..706946 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 706946 ybfA 7142493 ybfA Escherichia coli ED1a hypothetical protein YP_002396715.1 706740 D 585397 CDS YP_002396716.1 218688504 7138942 707047..707556 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6325460, 8387990; hypothetical protein 707556 ybgA 7138942 ybgA Escherichia coli ED1a hypothetical protein YP_002396716.1 707047 D 585397 CDS YP_002396717.1 218688505 7138947 707553..708971 1 NC_011745.1 UV-induced DNA repair; converts cyclobutane-type pyrimidine dimers created during exposure to UV ratiation to monomers; light dependent; deoxyribodipyrimidine photolyase 708971 phr 7138947 phr Escherichia coli ED1a deoxyribodipyrimidine photolyase YP_002396717.1 707553 D 585397 CDS YP_002396718.1 218688506 7144112 complement(709013..710494) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15175316; Product type pt : putative transporter; putative transporter 710494 ybgH 7144112 ybgH Escherichia coli ED1a putative transporter YP_002396718.1 709013 R 585397 CDS YP_002396719.1 218688507 7138951 710765..711508 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14519207; putative hydrolase-oxidase 711508 ybgI 7138951 ybgI Escherichia coli ED1a putative hydrolase-oxidase YP_002396719.1 710765 D 585397 CDS YP_002396720.1 218688508 7138952 711531..712187 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase subunit 712187 ybgJ 7138952 ybgJ Escherichia coli ED1a putative hydrolase subunit YP_002396720.1 711531 D 585397 CDS YP_002396721.1 218688509 7138953 712181..713113 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase subunit 713113 ybgK 7138953 ybgK Escherichia coli ED1a putative hydrolase subunit YP_002396721.1 712181 D 585397 CDS YP_002396722.1 218688510 7138954 713103..713837 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1729609; Product type pe : putative enzyme; LamB/YcsF family protein 713837 ybgL 7138954 ybgL Escherichia coli ED1a LamB/YcsF family protein YP_002396722.1 713103 D 585397 CDS YP_002396723.1 218688511 7138955 713873..714664 1 NC_011745.1 5-formyluracil/5-hydroxymethyluracil DNA glycosylase; involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; acts as DNA glycosylase that recognizes and removes damaged bases with a preference for oxidized pyrimidines; has apurinic/apyrimidinic lyase activity; endonuclease VIII 714664 nei 7138955 nei Escherichia coli ED1a endonuclease VIII YP_002396723.1 713873 D 585397 CDS YP_002396724.1 218688512 7140373 complement(714661..715707) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8002588; Product type ph : phenotype; hypothetical protein 715707 abrB 7140373 abrB Escherichia coli ED1a hypothetical protein YP_002396724.1 714661 R 585397 CDS YP_002396725.1 218688513 7138956 complement(716381..717664) 1 NC_011745.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase 717664 gltA 7138956 gltA Escherichia coli ED1a type II citrate synthase YP_002396725.1 716381 R 585397 CDS YP_002396726.1 218688514 7142978 complement(717870..718028) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 718028 7142978 ECED1_0690 Escherichia coli ED1a hypothetical protein YP_002396726.1 717870 R 585397 CDS YP_002396727.1 218688515 7141851 718373..718762 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6237244, 89076355, 89123360, 9521736, 99414342, 11259408, 3309132, 6383359, 9822661; Product type m : membrane component; succinate dehydrogenase cytochrome b556 large membrane subunit 718762 sdhC 7141851 sdhC Escherichia coli ED1a succinate dehydrogenase cytochrome b556 large membrane subunit YP_002396727.1 718373 D 585397 CDS YP_002396728.1 218688516 7141382 718756..719103 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82124790, 89076355, 9521736, 99414342, 6383359; Product type m : membrane component; succinate dehydrogenase cytochrome b556 small membrane subunit 719103 sdhD 7141382 sdhD Escherichia coli ED1a succinate dehydrogenase cytochrome b556 small membrane subunit YP_002396728.1 718756 D 585397 CDS YP_002396729.1 218688517 7141383 719103..720869 1 NC_011745.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 720869 sdhA 7141383 sdhA Escherichia coli ED1a succinate dehydrogenase flavoprotein subunit YP_002396729.1 719103 D 585397 CDS YP_002396730.1 218688518 7141380 720885..721601 1 NC_011745.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 721601 sdhB 7141380 sdhB Escherichia coli ED1a succinate dehydrogenase iron-sulfur subunit YP_002396730.1 720885 D 585397 CDS YP_002396731.1 218688519 7141381 722152..724953 1 NC_011745.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 component 724953 sucA 7141381 sucA Escherichia coli ED1a 2-oxoglutarate dehydrogenase E1 component YP_002396731.1 722152 D 585397 CDS YP_002396732.1 218688520 7143863 724968..726185 1 NC_011745.1 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA; dihydrolipoamide succinyltransferase 726185 sucB 7143863 sucB Escherichia coli ED1a dihydrolipoamide succinyltransferase YP_002396732.1 724968 D 585397 CDS YP_002396733.1 218688521 7143866 726279..727445 1 NC_011745.1 catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 727445 sucC 7143866 sucC Escherichia coli ED1a succinyl-CoA synthetase subunit beta YP_002396733.1 726279 D 585397 CDS YP_002396734.1 218688522 7143868 727445..728314 1 NC_011745.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 728314 sucD 7143868 sucD Escherichia coli ED1a succinyl-CoA synthetase subunit alpha YP_002396734.1 727445 D 585397 CDS YP_002396735.1 218688523 7140151 728554..729669 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 729669 7140151 ECED1_0699 Escherichia coli ED1a hypothetical protein YP_002396735.1 728554 D 585397 CDS YP_002396736.1 218688524 7141852 730999..732567 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87299685, 89255232, 91035243, 1689724, 1724280, 2843510, 3138232; Product type c : carrier; cytochrome d terminal oxidase subunit I 732567 cydA 7141852 cydA Escherichia coli ED1a cytochrome d terminal oxidase subunit I YP_002396736.1 730999 D 585397 CDS YP_002396737.1 218688525 7142098 732583..733722 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87299685, 89255232, 91035243, 2843510, 3138232; Product type c : carrier; cytochrome d terminal oxidase subunit II 733722 cydB 7142098 cydB Escherichia coli ED1a cytochrome d terminal oxidase subunit II YP_002396737.1 732583 D 585397 CDS YP_002396738.1 218688526 7142099 733850..734143 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 734143 ybgE 7142099 ybgE Escherichia coli ED1a hypothetical protein YP_002396738.1 733850 D 585397 CDS YP_002396739.1 218688527 7138949 734293..734697 1 NC_011745.1 catalyzes the hydrolysis of short chain aliphatic acyl-CoA thioesters; physiological role remains unknown; involved in phospholipid metabolism; part of the Tol/Pal system of proteins that are critical for maintaining the integrity of the cell envelope components; acyl-CoA thioester hydrolase YbgC 734697 ybgC 7138949 ybgC Escherichia coli ED1a acyl-CoA thioester hydrolase YbgC YP_002396739.1 734293 D 585397 CDS YP_002396740.1 218688528 7138948 734694..735386 1 NC_011745.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolQ 735386 tolQ 7138948 tolQ Escherichia coli ED1a colicin uptake protein TolQ YP_002396740.1 734694 D 585397 CDS YP_002396741.1 218688529 7141569 735390..735818 1 NC_011745.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolR 735818 tolR 7141569 tolR Escherichia coli ED1a colicin uptake protein TolR YP_002396741.1 735390 D 585397 CDS YP_002396742.1 218688530 7141570 735883..737148 1 NC_011745.1 inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins; cell envelope integrity inner membrane protein TolA 737148 tolA 7141570 tolA Escherichia coli ED1a cell envelope integrity inner membrane protein TolA YP_002396742.1 735883 D 585397 CDS YP_002396743.1 218688531 7141566 737281..738573 1 NC_011745.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA; translocation protein TolB 738573 tolB 7141566 tolB Escherichia coli ED1a translocation protein TolB YP_002396743.1 737281 D 585397 CDS YP_002396744.1 218688532 7141567 738608..739129 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11790745, 87133578, 92244043, 99403391, 11173492, 2687247; Product type lp : lipoprotein; peptidoglycan-associated outer membrane lipoprotein 739129 pal 7141567 pal Escherichia coli ED1a peptidoglycan-associated outer membrane lipoprotein YP_002396744.1 738608 D 585397 CDS YP_002396745.1 218688533 7144038 739139..739930 1 NC_011745.1 periplasmic protein that interacts with TolA; the tol-pal system is probably involved in maintaining cell envelope integrity; tol-pal system protein YbgF 739930 ybgF 7144038 ybgF Escherichia coli ED1a tol-pal system protein YbgF YP_002396745.1 739139 D 585397 CDS YP_002396746.1 218688534 7140778 741076..742119 1 NC_011745.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 742119 nadA 7140778 nadA Escherichia coli ED1a quinolinate synthetase YP_002396746.1 741076 D 585397 CDS YP_002396747.1 218688535 7140330 742157..742876 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 219824, 90330519; Product type t : transporter; nicotinamide mononucleotide transporter 742876 pnuC 7140330 pnuC Escherichia coli ED1a nicotinamide mononucleotide transporter YP_002396747.1 742157 D 585397 CDS YP_002396748.1 218688536 7139080 complement(742873..743814) 1 NC_011745.1 involved in zinc efflux across the cytoplasmic membrane; zinc transporter ZitB 743814 zitB 7139080 zitB Escherichia coli ED1a zinc transporter ZitB YP_002396748.1 742873 R 585397 CDS YP_002396749.1 218688537 7143275 complement(743928..744308) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 744308 ybgS 7143275 ybgS Escherichia coli ED1a hypothetical protein YP_002396749.1 743928 R 585397 CDS YP_002396750.1 218688538 7138957 744620..745672 1 NC_011745.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 745672 aroG 7138957 aroG Escherichia coli ED1a phospho-2-dehydro-3-deoxyheptonate aldolase YP_002396750.1 744620 D 585397 CDS YP_002396751.1 218688539 7142629 complement(745838..746590) 1 NC_011745.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 746590 gpmA 7142629 gpmA Escherichia coli ED1a phosphoglyceromutase YP_002396751.1 745838 R 585397 CDS YP_002396752.1 218688540 7143012 complement(746793..747833) 1 NC_011745.1 catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose; aldose 1-epimerase 747833 galM 7143012 galM Escherichia coli ED1a aldose 1-epimerase YP_002396752.1 746793 R 585397 CDS YP_002396753.1 218688541 7143151 complement(747827..748975) 1 NC_011745.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase 748975 galK 7143151 galK Escherichia coli ED1a galactokinase YP_002396753.1 747827 R 585397 CDS YP_002396754.1 218688542 7143150 complement(748979..750025) 1 NC_011745.1 catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P; galactose-1-phosphate uridylyltransferase 750025 galT 7143150 galT Escherichia coli ED1a galactose-1-phosphate uridylyltransferase YP_002396754.1 748979 R 585397 CDS YP_002396755.1 218688543 7143155 complement(750035..751051) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89274199, 92253563, 92338916, 3022232, 6301942, 8564363, 8611559, 8931134, 9174344, 9271499, 9708982; Product type e : enzyme; UDP-galactose-4-epimerase 751051 galE 7143155 galE Escherichia coli ED1a UDP-galactose-4-epimerase YP_002396755.1 750035 R 585397 CDS YP_002396756.1 218688544 7143148 complement(751312..752784) 1 NC_011745.1 contains 2 ATP-binding cassettes; involved in the transport of molybdenum; putative molybdenum transport ATP-binding protein ModF 752784 modF 7143148 modF Escherichia coli ED1a putative molybdenum transport ATP-binding protein ModF YP_002396756.1 751312 R 585397 CDS YP_002396757.1 218688545 7139008 complement(752712..752858) 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 752858 7139008 ECED1_0722 Escherichia coli ED1a hypothetical protein YP_002396757.1 752712 R 585397 CDS YP_002396758.1 218688546 7141853 complement(752852..753640) 1 NC_011745.1 represses the modABCD operon and activates the moaABCD and napFDAGHBC operons; DNA-binding transcriptional regulator ModE 753640 modE 7141853 modE Escherichia coli ED1a DNA-binding transcriptional regulator ModE YP_002396758.1 752852 R 585397 CDS YP_002396759.1 218688547 7139007 753769..753918 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 753918 ybhT 7139007 ybhT Escherichia coli ED1a hypothetical protein YP_002396759.1 753769 D 585397 CDS YP_002396760.1 218688548 7142662 754085..754858 1 NC_011745.1 with ModCB is involved in the high-affinity transport of molybdate; molybdate transporter periplasmic protein 754858 modA 7142662 modA Escherichia coli ED1a molybdate transporter periplasmic protein YP_002396760.1 754085 D 585397 CDS YP_002396761.1 218688549 7139003 754858..755547 1 NC_011745.1 part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE; molybdate ABC transporter permease 755547 modB 7139003 modB Escherichia coli ED1a molybdate ABC transporter permease YP_002396761.1 754858 D 585397 CDS YP_002396762.1 218688550 7139004 755550..756608 1 NC_011745.1 Part of the ABC transporter complex modABC involved in molybdenum import; molybdate transporter ATP-binding protein 756608 modC 7139004 modC Escherichia coli ED1a molybdate transporter ATP-binding protein YP_002396762.1 755550 D 585397 CDS YP_002396763.1 218688551 7139005 complement(756609..757427) 1 NC_011745.1 YbhA; catalyzes the dephosphorylation of pyridoxal phosphate, fructose 1,6-bisphosphate, erythrose 4-phosphate and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; phosphotransferase activity observed when using monophosphates as phosphate donor; member of the haloacid dehalogenase-like hydrolases superfamily; phosphotransferase 757427 ybhA 7139005 ybhA Escherichia coli ED1a phosphotransferase YP_002396763.1 756609 R 585397 CDS YP_002396764.1 218688552 7138958 757582..758577 1 NC_011745.1 catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate; 6-phosphogluconolactonase 758577 pgl 7138958 pgl Escherichia coli ED1a 6-phosphogluconolactonase YP_002396764.1 757582 D 585397 CDS YP_002396765.1 218688553 7138962 759754..760806 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 760806 ybhH 7138962 ybhH Escherichia coli ED1a hypothetical protein YP_002396765.1 759754 D 585397 CDS YP_002396766.1 218688554 7138965 760882..762315 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative anion transporter 762315 ybhI 7138965 ybhI Escherichia coli ED1a putative anion transporter YP_002396766.1 760882 D 585397 CDS YP_002396767.1 218688555 7138966 762216..762386 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 762386 7138966 ECED1_0734 Escherichia coli ED1a hypothetical protein YP_002396767.1 762216 D 585397 CDS YP_002396768.1 218688556 7141854 762498..764759 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11782506; Product type pe : putative enzyme; hypothetical protein 764759 ybhJ 7141854 ybhJ Escherichia coli ED1a hypothetical protein YP_002396768.1 762498 D 585397 CDS YP_002396769.1 218688557 7138967 complement(764900..766183) 1 NC_011745.1 outer membrane lipoprotein that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; YbhC localizes to the cellular poles; member of pectinesterase family; putative pectinesterase 766183 ybhC 7138967 ybhC Escherichia coli ED1a putative pectinesterase YP_002396769.1 764900 R 585397 CDS YP_002396770.1 218688558 7138960 complement(766335..766811) 1 NC_011745.1 YbhB; similar to rat and human kinase inhibitory proteins; putative kinase inhibitor protein 766811 ybhB 7138960 ybhB Escherichia coli ED1a putative kinase inhibitor protein YP_002396770.1 766335 R 585397 CDS YP_002396771.1 218688559 7138959 complement(766870..768159) 1 NC_011745.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine--8-amino-7-oxononanoate transaminase 768159 bioA 7138959 bioA Escherichia coli ED1a adenosylmethionine--8-amino-7-oxononanoate transaminase YP_002396771.1 766870 R 585397 CDS YP_002396772.1 218688560 7140450 768246..769286 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11834738, 12475249, 14704425, 14967041, 20250955, 89066784, 94170810, 94190882, 97382445, 11686925; Product type e : enzyme; biotin synthase 769286 bioB 7140450 bioB Escherichia coli ED1a biotin synthase YP_002396772.1 768246 D 585397 CDS YP_002396773.1 218688561 7140451 769283..770437 1 NC_011745.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 770437 bioF 7140451 bioF Escherichia coli ED1a 8-amino-7-oxononanoate synthase YP_002396773.1 769283 D 585397 CDS YP_002396774.1 218688562 7140454 770424..771179 1 NC_011745.1 putative methyltransferase; acyl carrier protein involved in an unidentified step in the synthesis of pimeloyl-CoA, a biotin precursor; member of the bio operon (bioABFCD); in Escherichia coli, bioC-null mutants require biotin for growth; biotin biosynthesis protein BioC 771179 bioC 7140454 bioC Escherichia coli ED1a biotin biosynthesis protein BioC YP_002396774.1 770424 D 585397 CDS YP_002396775.1 218688563 7140452 771172..771849 1 NC_011745.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 771849 bioD 7140452 bioD Escherichia coli ED1a dithiobiotin synthetase YP_002396775.1 771172 D 585397 CDS YP_002396776.1 218688564 7140453 772428..774449 1 NC_011745.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 774449 uvrB 7140453 uvrB Escherichia coli ED1a excinuclease ABC subunit B YP_002396776.1 772428 D 585397 CDS YP_002396777.1 218688565 7139151 complement(774487..775395) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16272399; Product type pe : putative enzyme; putative transferase 775395 ybhK 7139151 ybhK Escherichia coli ED1a putative transferase YP_002396777.1 774487 R 585397 CDS YP_002396778.1 218688566 7138968 complement(775638..775793) 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 775793 7138968 ECED1_0745 Escherichia coli ED1a hypothetical protein YP_002396778.1 775638 R 585397 CDS YP_002396779.1 218688567 7141855 775792..776781 1 NC_011745.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; molybdenum cofactor biosynthesis protein A 776781 moaA 7141855 moaA Escherichia coli ED1a molybdenum cofactor biosynthesis protein A YP_002396779.1 775792 D 585397 CDS YP_002396780.1 218688568 7138996 776803..777315 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93368423; Product type pf : putative factor; molybdopterin biosynthesis protein B 777315 moaB 7138996 moaB Escherichia coli ED1a molybdopterin biosynthesis protein B YP_002396780.1 776803 D 585397 CDS YP_002396781.1 218688569 7138997 777318..777803 1 NC_011745.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC 777803 moaC 7138997 moaC Escherichia coli ED1a molybdenum cofactor biosynthesis protein MoaC YP_002396781.1 777318 D 585397 CDS YP_002396782.1 218688570 7138998 777796..778041 1 NC_011745.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin synthase small subunit 778041 moaD 7138998 moaD Escherichia coli ED1a molybdopterin synthase small subunit YP_002396782.1 777796 D 585397 CDS YP_002396783.1 218688571 7138999 778043..778495 1 NC_011745.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin guanine dinucleotide biosynthesis protein MoaE 778495 moaE 7138999 moaE Escherichia coli ED1a molybdopterin guanine dinucleotide biosynthesis protein MoaE YP_002396783.1 778043 D 585397 CDS YP_002396784.1 218688572 7139000 778632..779336 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 779336 ybhL 7139000 ybhL Escherichia coli ED1a hypothetical protein YP_002396784.1 778632 D 585397 CDS YP_002396785.1 218688573 7138969 779542..780255 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 780255 ybhM 7138969 ybhM Escherichia coli ED1a hypothetical protein YP_002396785.1 779542 D 585397 CDS YP_002396786.1 218688574 7138970 complement(780291..781247) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 781247 ybhN 7138970 ybhN Escherichia coli ED1a hypothetical protein YP_002396786.1 780291 R 585397 CDS YP_002396787.1 218688575 7138971 complement(781247..782488) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20102623, 10634942; Product type e : enzyme; cardiolipin synthase 2 782488 ybhO 7138971 ybhO Escherichia coli ED1a cardiolipin synthase 2 YP_002396787.1 781247 R 585397 CDS YP_002396788.1 218688576 7138972 complement(782485..783246) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative metal-dependent hydrolase 783246 ybhP 7138972 ybhP Escherichia coli ED1a putative metal-dependent hydrolase YP_002396788.1 782485 R 585397 CDS YP_002396789.1 218688577 7138973 783379..783789 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 783789 ybhQ 7138973 ybhQ Escherichia coli ED1a hypothetical protein YP_002396789.1 783379 D 585397 CDS YP_002396790.1 218688578 7138974 complement(783751..784857) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter permease 784857 ybhR 7138974 ybhR Escherichia coli ED1a putative ABC transporter permease YP_002396790.1 783751 R 585397 CDS YP_002396791.1 218688579 7138975 complement(784868..786001) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter permease 786001 ybhS 7138975 ybhS Escherichia coli ED1a putative ABC transporter permease YP_002396791.1 784868 R 585397 CDS YP_002396792.1 218688580 7139222 complement(785994..787730) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATP-binding protein 787730 ybhF 7139222 ybhF Escherichia coli ED1a putative ABC transporter ATP-binding protein YP_002396792.1 785994 R 585397 CDS YP_002396793.1 218688581 7138963 complement(787723..788721) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16092522; Product type pt : putative transporter; hypothetical protein 788721 ybhG 7138963 ybhG Escherichia coli ED1a hypothetical protein YP_002396793.1 787723 R 585397 CDS YP_002396794.1 218688582 7138964 complement(788721..789392) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 789392 ybiH 7138964 ybiH Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002396794.1 788721 R 585397 CDS YP_002396795.1 218688583 7142666 789621..790982 1 NC_011745.1 this helicase is not essential cell growth; ATP-dependent RNA helicase RhlE 790982 rhlE 7142666 rhlE Escherichia coli ED1a ATP-dependent RNA helicase RhlE YP_002396795.1 789621 D 585397 CDS YP_002396796.1 218688584 7141614 complement(791215..791520) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 791520 ybiA 7141614 ybiA Escherichia coli ED1a hypothetical protein YP_002396796.1 791215 R 585397 CDS YP_002396797.1 218688585 7142663 791519..793669 1 NC_011745.1 helicase involved in DNA repair and perhaps also replication; ATP-dependent DNA helicase DinG 793669 dinG 7142663 dinG Escherichia coli ED1a ATP-dependent DNA helicase DinG YP_002396797.1 791519 D 585397 CDS YP_002396798.1 218688586 7140490 793697..794659 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; glycosyl transferase family protein 794659 ybiB 7140490 ybiB Escherichia coli ED1a glycosyl transferase family protein YP_002396798.1 793697 D 585397 CDS YP_002396799.1 218688587 7142664 794800..795885 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8405966; Product type pe : putative enzyme; hypothetical protein 795885 ybiC 7142664 ybiC Escherichia coli ED1a hypothetical protein YP_002396799.1 794800 D 585397 CDS YP_002396800.1 218688588 7142665 complement(796114..796374) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 796374 ybiJ 7142665 ybiJ Escherichia coli ED1a hypothetical protein YP_002396800.1 796114 R 585397 CDS YP_002396801.1 218688589 7142668 complement(796639..796905) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 796905 ybiI 7142668 ybiI Escherichia coli ED1a hypothetical protein YP_002396801.1 796639 R 585397 CDS YP_002396802.1 218688590 7142667 complement(796979..797656) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative hydroxylase 797656 ybiX 7142667 ybiX Escherichia coli ED1a putative hydroxylase YP_002396802.1 796979 R 585397 CDS YP_002396803.1 218688591 7142678 complement(797872..800154) 1 NC_011745.1 Fiu; YbiL; porin involved in the uptake of iron complexed with catecholate siderophores (e.g. dihydroxybenzoylserine, dihydroxybenzoate) and beta lactam agents; Fiu interacts with TonB which provides the energy required for transport across the outer membrane; acts as a receptor for iron-siderophores and microcins E492, M, and H47; outer membrane protein; catecholate siderophore receptor Fiu 800154 fiu 7142678 fiu Escherichia coli ED1a catecholate siderophore receptor Fiu YP_002396803.1 797872 R 585397 CDS YP_002396804.1 218688592 7144188 complement(800419..800823) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 800823 ybiM 7144188 ybiM Escherichia coli ED1a hypothetical protein YP_002396804.1 800419 R 585397 CDS YP_002396805.1 218688593 7142669 800955..801881 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative SAM-dependent methyltransferase 801881 ybiN 7142669 ybiN Escherichia coli ED1a putative SAM-dependent methyltransferase YP_002396805.1 800955 D 585397 CDS YP_002396806.1 218688594 7142670 complement(801878..804103) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 804103 ybiO 7142670 ybiO Escherichia coli ED1a hypothetical protein YP_002396806.1 801878 R 585397 CDS YP_002396807.1 218688595 7142671 complement(804220..804942) 1 NC_011745.1 similar to ATP-binding component of ABC transporters; glutamine ABC transporter ATP-binding protein 804942 glnQ 7142671 glnQ Escherichia coli ED1a glutamine ABC transporter ATP-binding protein YP_002396807.1 804220 R 585397 CDS YP_002396808.1 218688596 7142962 complement(804939..805598) 1 NC_011745.1 similar to permease component of ABC transporters; mutations impair ability of Escherichia coli to transport and utilize glutamine; glutamine ABC transporter permease 805598 glnP 7142962 glnP Escherichia coli ED1a glutamine ABC transporter permease YP_002396808.1 804939 R 585397 CDS YP_002396809.1 218688597 7142961 complement(805737..806483) 1 NC_011745.1 similar to periplasmic-binding component of ABC transporters; glutamine ABC transporter periplasmic protein 806483 glnH 7142961 glnH Escherichia coli ED1a glutamine ABC transporter periplasmic protein YP_002396809.1 805737 R 585397 CDS YP_002396810.1 218688598 7142958 complement(806887..807390) 1 NC_011745.1 binds DNA in a non-sequence-specific manner and is abundant during stationary phase; forms a DNA-protein crystal that protects DNA from damage; required for normal starvation response and long-term stationary viability; forms a homododecameric complex and sequesters iron which provides protection against oxidative damage; DNA starvation/stationary phase protection protein Dps 807390 dps 7142958 dps Escherichia coli ED1a DNA starvation/stationary phase protection protein Dps YP_002396810.1 806887 R 585397 CDS YP_002396811.1 218688599 7141618 808930..809445 1 NC_011745.1 OmpX; involved in cell adhesion; forms an eight-stranded antiparallel beta-barrel that protrudes from the cell surface; mutations in the gene increase cell-surface contact in fimbriated strains but decrease contact in nonfimbriated strains; outer membrane protein X 809445 ompX 7141618 ompX Escherichia coli ED1a outer membrane protein X YP_002396811.1 808930 D 585397 CDS YP_002396812.1 218688600 7139977 complement(809495..811078) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16514146; Product type pe : putative enzyme; hypothetical protein 811078 ybiP 7139977 ybiP Escherichia coli ED1a hypothetical protein YP_002396812.1 809495 R 585397 CDS YP_002396813.1 218688601 7140149 811664..812131 1 NC_011745.1 Transcriptional regulator that represses the manganese transporter MntH when manganese is present; manganese transport regulator MntR 812131 mntR 7140149 mntR Escherichia coli ED1a manganese transport regulator MntR YP_002396813.1 811664 D 585397 CDS YP_002396814.1 218688602 7138995 812128..813246 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 813246 ybiR 7138995 ybiR Escherichia coli ED1a putative transporter YP_002396814.1 812128 D 585397 CDS YP_002396815.1 218688603 7142673 complement(813304..814224) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10493123, 9298646; hypothetical protein 814224 ybiS 7142673 ybiS Escherichia coli ED1a hypothetical protein YP_002396815.1 813304 R 585397 CDS YP_002396816.1 218688604 7142674 814443..816035 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11916677; Product type pt : putative transporter; putative ABC transporter ATP-binding protein 816035 ybiT 7142674 ybiT Escherichia coli ED1a putative ABC transporter ATP-binding protein YP_002396816.1 814443 D 585397 CDS YP_002396817.1 218688605 7142675 complement(816235..817050) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15657928; Product type e : enzyme; type II HAD phosphatase 817050 ybiV 7142675 ybiV Escherichia coli ED1a type II HAD phosphatase YP_002396817.1 816235 R 585397 CDS YP_002396818.1 218688606 7142676 complement(817196..819628) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16218870; Product type pe : putative enzyme; putative glycyl radical cofactor protein 819628 ybiW 7142676 ybiW Escherichia coli ED1a putative glycyl radical cofactor protein YP_002396818.1 817196 R 585397 CDS YP_002396819.1 218688607 7142677 complement(819634..820560) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15581584; Product type pe : putative enzyme; putative AdoMet-dependent glycyl radical activating enzyme 820560 ybiY 7142677 ybiY Escherichia coli ED1a putative AdoMet-dependent glycyl radical activating enzyme YP_002396819.1 819634 R 585397 CDS YP_002396820.1 218688608 7142679 820664..821326 1 NC_011745.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 821326 fsaA 7142679 fsaA Escherichia coli ED1a fructose-6-phosphate aldolase YP_002396820.1 820664 D 585397 CDS YP_002396821.1 218688609 7142184 complement(821402..822151) 1 NC_011745.1 ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase; molybdopterin biosynthesis protein MoeB 822151 moeB 7142184 moeB Escherichia coli ED1a molybdopterin biosynthesis protein MoeB YP_002396821.1 821402 R 585397 CDS YP_002396822.1 218688610 7139010 complement(822151..823386) 1 NC_011745.1 is involved in the formation of active molybdenum cofactor and the chelation of molybdenum; molybdopterin biosynthesis protein MoeA 823386 moeA 7139010 moeA Escherichia coli ED1a molybdopterin biosynthesis protein MoeA YP_002396822.1 822151 R 585397 CDS YP_002396823.1 218688611 7139009 823590..824555 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15159592, 20508248, 3045084, 7984428; Product type e : enzyme; L-asparaginase 824555 iaaA 7139009 iaaA Escherichia coli ED1a L-asparaginase YP_002396823.1 823590 D 585397 CDS YP_002396824.1 218688612 7140213 824575..826413 1 NC_011745.1 with GsiBCD is involved in glutathione import; GsiA contains 2 ATP-binding domains; glutathione transporter ATP-binding protein 826413 yliA 7140213 yliA Escherichia coli ED1a glutathione transporter ATP-binding protein YP_002396824.1 824575 D 585397 CDS YP_002396825.1 218688613 7140962 826433..827971 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 17366475; Product type pt : putative transporter; putative peptide ABC transporter periplasmic-binding protein 827971 yliB 7140962 yliB Escherichia coli ED1a putative peptide ABC transporter periplasmic-binding protein YP_002396825.1 826433 D 585397 CDS YP_002396826.1 218688614 7140963 827989..828909 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative peptide ABC transporter permease 828909 yliC 7140963 yliC Escherichia coli ED1a putative peptide ABC transporter permease YP_002396826.1 827989 D 585397 CDS YP_002396827.1 218688615 7140964 828912..829823 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative peptide ABC transporter permease 829823 yliD 7140964 yliD Escherichia coli ED1a putative peptide ABC transporter permease YP_002396827.1 828912 D 585397 CDS YP_002396828.1 218688616 7140965 830000..832348 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 832348 yliE 7140965 yliE Escherichia coli ED1a hypothetical protein YP_002396828.1 830000 D 585397 CDS YP_002396829.1 218688617 7140966 832356..833684 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15380559; Product type pe : putative enzyme; putative diguanylate cyclase 833684 yliF 7140966 yliF Escherichia coli ED1a putative diguanylate cyclase YP_002396829.1 832356 D 585397 CDS YP_002396830.1 218688618 7140967 complement(833731..835056) 1 NC_011745.1 catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit; ribosomal protein S12 methylthiotransferase 835056 rimO 7140967 rimO Escherichia coli ED1a ribosomal protein S12 methylthiotransferase YP_002396830.1 833731 R 585397 CDS YP_002396831.1 218688619 7140968 835269..835652 1 NC_011745.1 BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing; biofilm formation regulatory protein BssR 835652 bssR 7140968 bssR Escherichia coli ED1a biofilm formation regulatory protein BssR YP_002396831.1 835269 D 585397 CDS YP_002396832.1 218688620 7140463 835763..836878 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16522795, 16864586; Product type e : enzyme; PQQ-dependent aldose sugar dehydrogenase (asd) 836878 yliI 7140463 yliI Escherichia coli ED1a PQQ-dependent aldose sugar dehydrogenase (asd) YP_002396832.1 835763 D 585397 CDS YP_002396833.1 218688621 7140969 complement(836875..837501) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glutathione S-transferase 837501 yliJ 7140969 yliJ Escherichia coli ED1a putative glutathione S-transferase YP_002396833.1 836875 R 585397 CDS YP_002396834.1 218688622 7140970 837748..838950 1 NC_011745.1 penicillin-binding protein 6a; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase fraction C 838950 dacC 7140970 dacC Escherichia coli ED1a D-alanyl-D-alanine carboxypeptidase fraction C YP_002396834.1 837748 D 585397 CDS YP_002396835.1 218688623 7143054 complement(838997..839755) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89231635, 89336786, 92231401, 2994018; Product type r : regulator; DNA-binding transcriptional repressor DeoR 839755 deoR 7143054 deoR Escherichia coli ED1a DNA-binding transcriptional repressor DeoR YP_002396835.1 838997 R 585397 CDS YP_002396836.1 218688624 7143097 complement(839813..840409) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15778224; Product type e : enzyme; undecaprenyl pyrophosphate phosphatase 840409 ybjG 7143097 ybjG Escherichia coli ED1a undecaprenyl pyrophosphate phosphatase YP_002396836.1 839813 R 585397 CDS YP_002396837.1 218688625 7142683 840694..841926 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10022825, 12578981, 14688269, 21217867, 21450803, 9079913, 9644262, 99030337, 8655497; Product type t : transporter; multidrug efflux system protein 841926 cmr 7142683 cmr Escherichia coli ED1a multidrug efflux system protein YP_002396837.1 840694 D 585397 CDS YP_002396838.1 218688626 7139381 complement(841967..842251) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 842251 ybjH 7139381 ybjH Escherichia coli ED1a hypothetical protein YP_002396838.1 841967 R 585397 CDS YP_002396839.1 218688627 7142684 complement(842337..843125) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15808744; Product type pe : putative enzyme; putative phosphatase 843125 ybjI 7142684 ybjI Escherichia coli ED1a putative phosphatase YP_002396839.1 842337 R 585397 CDS YP_002396840.1 218688628 7142685 complement(843141..844349) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 844349 ybjJ 7142685 ybjJ Escherichia coli ED1a putative transporter YP_002396840.1 843141 R 585397 CDS YP_002396841.1 218688629 7142686 844433..844969 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 844969 ybjK 7142686 ybjK Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002396841.1 844433 D 585397 CDS YP_002396842.1 218688630 7140746 complement(845144..846829) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; hypothetical protein 846829 ybjL 7140746 ybjL Escherichia coli ED1a hypothetical protein YP_002396842.1 845144 R 585397 CDS YP_002396843.1 218688631 7142688 847099..847476 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 847476 ybjM 7142688 ybjM Escherichia coli ED1a hypothetical protein YP_002396843.1 847099 D 585397 CDS YP_002396844.1 218688632 7142689 complement(847506..847763) 1 NC_011745.1 functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase; glutaredoxin 1 847763 grxA 7142689 grxA Escherichia coli ED1a glutaredoxin 1 YP_002396844.1 847506 R 585397 CDS YP_002396845.1 218688633 7143024 847923..848210 1 NC_011745.1 YbjC; located in the same operon as the nfsA gene; member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress; induced by paraquat; regulated by SoxS; unknown function; hypothetical protein 848210 ybjC 7143024 ybjC Escherichia coli ED1a hypothetical protein YP_002396845.1 847923 D 585397 CDS YP_002396846.1 218688634 7142680 848194..848916 1 NC_011745.1 NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds; nitroreductase A 848916 nfsA 7142680 nfsA Escherichia coli ED1a nitroreductase A YP_002396846.1 848194 D 585397 CDS YP_002396847.1 218688635 7140381 848977..849879 1 NC_011745.1 responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6; ribosomal protein S6 modification protein 849879 rimK 7140381 rimK Escherichia coli ED1a ribosomal protein S6 modification protein YP_002396847.1 848977 D 585397 CDS YP_002396848.1 218688636 7141418 849967..850443 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 850443 ybjN 7141418 ybjN Escherichia coli ED1a hypothetical protein YP_002396848.1 849967 D 585397 CDS YP_002396849.1 218688637 7142690 850792..851904 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93106992, 9651355, 9298646, 8416922; Product type t : transporter; putrescine ABC transporter periplasmic-binding protein 851904 potF 7142690 potF Escherichia coli ED1a putrescine ABC transporter periplasmic-binding protein YP_002396849.1 850792 D 585397 CDS YP_002396850.1 218688638 7139088 851999..853132 1 NC_011745.1 part of the PotFGHI ATP-dependent putrescine transporter; putrescine transporter ATP-binding subunit 853132 potG 7139088 potG Escherichia coli ED1a putrescine transporter ATP-binding subunit YP_002396850.1 851999 D 585397 CDS YP_002396851.1 218688639 7139091 854082..854927 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93106992; Product type t : transporter; putrescine ABC transporter membrane protein 854927 potI 7139091 potI Escherichia coli ED1a putrescine ABC transporter membrane protein YP_002396851.1 854082 D 585397 CDS YP_002396852.1 218688640 7139092 854987..855475 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 855475 ybjO 7139092 ybjO Escherichia coli ED1a hypothetical protein YP_002396852.1 854987 D 585397 CDS YP_002396853.1 218688641 7142691 855516..856643 1 NC_011745.1 RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA; 23S rRNA methyluridine methyltransferase 856643 rumB 7142691 rumB Escherichia coli ED1a 23S rRNA methyluridine methyltransferase YP_002396853.1 855516 D 585397 CDS YP_002396854.1 218688642 7140136 complement(856672..857403) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93273744, 9298646, 9600841, 8801422; Product type t : transporter; arginine ABC transporter subunit periplasmic-binding protein 857403 artJ 7140136 artJ Escherichia coli ED1a arginine ABC transporter subunit periplasmic-binding protein YP_002396854.1 856672 R 585397 CDS YP_002396855.1 218688643 7142637 complement(857629..858297) 1 NC_011745.1 with ArtPQJI acts to transport arginine across the inner membrane; arginine transporter permease subunit ArtM 858297 artM 7142637 artM Escherichia coli ED1a arginine transporter permease subunit ArtM YP_002396855.1 857629 R 585397 CDS YP_002396856.1 218688644 7142638 complement(858297..859013) 1 NC_011745.1 with ArtPMJI transports arginine across the inner membrane; arginine transporter permease subunit ArtQ 859013 artQ 7142638 artQ Escherichia coli ED1a arginine transporter permease subunit ArtQ YP_002396856.1 858297 R 585397 CDS YP_002396857.1 218688645 7142640 complement(859020..859751) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93273744, 9298646, 9600841, 8801422, 9740056; Product type t : transporter; arginine ABC transporter subunit periplasmic-binding protein 859751 artI 7142640 artI Escherichia coli ED1a arginine ABC transporter subunit periplasmic-binding protein YP_002396857.1 859020 R 585397 CDS YP_002396858.1 218688646 7142636 complement(859769..860497) 1 NC_011745.1 With ArtMQJI transports arginine across the inner membrane; arginine transporter ATP-binding subunit 860497 artP 7142636 artP Escherichia coli ED1a arginine transporter ATP-binding subunit YP_002396858.1 859769 R 585397 CDS YP_002396859.1 218688647 7142639 complement(860715..861230) 1 NC_011745.1 induced during stationary phase and by acivicin (a glutamine analog); regulated by Lrp and RpoS; putative lipoprotein 861230 ybjP 7142639 ybjP Escherichia coli ED1a putative lipoprotein YP_002396859.1 860715 R 585397 CDS YP_002396860.1 218688648 7142692 861356..861679 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 861679 ybjQ 7142692 ybjQ Escherichia coli ED1a hypothetical protein YP_002396860.1 861356 D 585397 CDS YP_002396861.1 218688649 7142693 861676..862506 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative cell wall amidase and lipoprotein 862506 ybjR 7142693 ybjR Escherichia coli ED1a putative cell wall amidase and lipoprotein YP_002396861.1 861676 D 585397 CDS YP_002396862.1 218688650 7142694 complement(862503..863516) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative NAD(P)H-binding oxidoreductase with NAD(P)-binding Rossmann-fold domain 863516 ybjS 7142694 ybjS Escherichia coli ED1a putative NAD(P)H-binding oxidoreductase with NAD(P)-binding Rossmann-fold domain YP_002396862.1 862503 R 585397 CDS YP_002396863.1 218688651 7142695 complement(863615..865045) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 865045 ybjT 7142695 ybjT Escherichia coli ED1a hypothetical protein YP_002396863.1 863615 R 585397 CDS YP_002396864.1 218688652 7142696 complement(865056..866057) 1 NC_011745.1 low- specificity; catalyzes the formation of acetaldehyde and glycine from L-threonine; acts on L-threonine, L-allo-threonine, L-threo-phenylserine, and L-erythro-phenylserine; L-threonine aldolase 866057 ltaE 7142696 ltaE Escherichia coli ED1a L-threonine aldolase YP_002396864.1 865056 R 585397 CDS YP_002396865.1 218688653 7141928 complement(866094..867812) 1 NC_011745.1 catalyzes the formation of acetate from pyruvate; pyruvate dehydrogenase 867812 poxB 7141928 poxB Escherichia coli ED1a pyruvate dehydrogenase YP_002396865.1 866094 R 585397 CDS YP_002396866.1 218688654 7139094 complement(867945..868913) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20117674; Product type e : enzyme; HCP oxidoreductase, NADH-dependent 868913 hcr 7139094 hcr Escherichia coli ED1a HCP oxidoreductase, NADH-dependent YP_002396866.1 867945 R 585397 CDS YP_002396867.1 218688655 7139857 complement(868925..870577) 1 NC_011745.1 catalyzes the reduction of hydroxylamine to ammonia and water; hydroxylamine reductase 870577 hcp 7139857 hcp Escherichia coli ED1a hydroxylamine reductase YP_002396867.1 868925 R 585397 CDS YP_002396868.1 218688656 7139856 complement(870721..871620) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 871620 ybjE 7139856 ybjE Escherichia coli ED1a putative transporter YP_002396868.1 870721 R 585397 CDS YP_002396869.1 218688657 7142682 complement(872115..872810) 1 NC_011745.1 porin involved in osmoregulation allowing water to move into and out of the cell in response to osmotic pressure; aquaporin Z 872810 aqpZ 7142682 aqpZ Escherichia coli ED1a aquaporin Z YP_002396869.1 872115 R 585397 CDS YP_002396870.1 218688658 7142595 873236..874894 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 874894 ybjD 7142595 ybjD Escherichia coli ED1a hypothetical protein YP_002396870.1 873236 D 585397 CDS YP_002396871.1 218688659 7142681 complement(874891..875883) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 875883 ybjX 7142681 ybjX Escherichia coli ED1a hypothetical protein YP_002396871.1 874891 R 585397 CDS YP_002396872.1 218688660 7142697 875998..877113 1 NC_011745.1 confers macrolide resistance via active drug efflux; macrolide transporter subunit MacA 877113 macA 7142697 macA Escherichia coli ED1a macrolide transporter subunit MacA YP_002396872.1 875998 D 585397 CDS YP_002396873.1 218688661 7141940 877110..879056 1 NC_011745.1 with MacA is involved in the export of macrolide; macrolide transporter ATP-binding /permease 879056 macB 7141940 macB Escherichia coli ED1a macrolide transporter ATP-binding /permease YP_002396873.1 877110 D 585397 CDS YP_002396874.1 218688662 7141941 complement(879129..879353) 1 NC_011745.1 inhibits DNA replication at both initiation and elongation steps; stationary phase and starvation inducible; stationary phase/starvation inducible regulatory protein CspD 879353 cspD 7141941 cspD Escherichia coli ED1a stationary phase/starvation inducible regulatory protein CspD YP_002396874.1 879129 R 585397 CDS YP_002396875.1 218688663 7142071 879676..879996 1 NC_011745.1 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA; ATP-dependent Clp protease adaptor protein ClpS 879996 clpS 7142071 clpS Escherichia coli ED1a ATP-dependent Clp protease adaptor protein ClpS YP_002396875.1 879676 D 585397 CDS YP_002396876.1 218688664 7139377 880027..882303 1 NC_011745.1 ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease; directs protease to specific substrates; ATP-dependent Clp protease ATP-binding subunit 882303 clpA 7139377 clpA Escherichia coli ED1a ATP-dependent Clp protease ATP-binding subunit YP_002396876.1 880027 D 585397 CDS YP_002396877.1 218688665 7139374 883720..884709 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 884709 7139374 ECED1_0850 Escherichia coli ED1a hypothetical protein YP_002396877.1 883720 D 585397 CDS YP_002396878.1 218688666 7141856 884706..887939 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative CRISPR-associated helicase 887939 7141856 ECED1_0851 Escherichia coli ED1a putative CRISPR-associated helicase YP_002396878.1 884706 D 585397 CDS YP_002396879.1 218688667 7141857 888269..889576 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 889576 7141857 ECED1_0852 Escherichia coli ED1a hypothetical protein YP_002396879.1 888269 D 585397 CDS YP_002396880.1 218688668 7141858 889573..890496 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 890496 7141858 ECED1_0853 Escherichia coli ED1a hypothetical protein YP_002396880.1 889573 D 585397 CDS YP_002396881.1 218688669 7141859 890507..891508 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 891508 7141859 ECED1_0854 Escherichia coli ED1a hypothetical protein YP_002396881.1 890507 D 585397 CDS YP_002396882.1 218688670 7141860 891477..892073 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 892073 7141860 ECED1_0855 Escherichia coli ED1a hypothetical protein YP_002396882.1 891477 D 585397 CDS YP_002396883.1 218688671 7140632 complement(892677..892970) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 892970 7140632 ECED1_0857 Escherichia coli ED1a hypothetical protein YP_002396883.1 892677 R 585397 CDS YP_002396884.1 218688672 7141862 complement(893537..893755) 1 NC_011745.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 893755 infA 7141862 infA Escherichia coli ED1a translation initiation factor IF-1 YP_002396884.1 893537 R 585397 CDS YP_002396885.1 218688673 7141109 complement(894040..894744) 1 NC_011745.1 leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys; leucyl/phenylalanyl-tRNA--protein transferase 894744 aat 7141109 aat Escherichia coli ED1a leucyl/phenylalanyl-tRNA--protein transferase YP_002396885.1 894040 R 585397 CDS YP_002396886.1 218688674 7143630 complement(894786..896507) 1 NC_011745.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein 896507 cydC 7143630 cydC Escherichia coli ED1a cysteine/glutathione ABC transporter membrane/ATP-binding protein YP_002396886.1 894786 R 585397 CDS YP_002396887.1 218688675 7142100 complement(896508..898274) 1 NC_011745.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein 898274 cydD 7142100 cydD Escherichia coli ED1a cysteine/glutathione ABC transporter membrane/ATP-binding protein YP_002396887.1 896508 R 585397 CDS YP_002396888.1 218688676 7142101 complement(898397..899362) 1 NC_011745.1 catalyzes the transfer of electrons from NADPH to thioredoxin; FAD/NAD(P) binding; thioredoxin reductase 899362 trxB 7142101 trxB Escherichia coli ED1a thioredoxin reductase YP_002396888.1 898397 R 585397 CDS YP_002396889.1 218688677 7140832 899906..900400 1 NC_011745.1 mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system; leucine-responsive transcriptional regulator 900400 lrp 7140832 lrp Escherichia coli ED1a leucine-responsive transcriptional regulator YP_002396889.1 899906 D 585397 CDS YP_002396890.1 218688678 7141926 900535..904602 1 NC_011745.1 DNA-binding membrane protein required for chromosome resolution and partitioning; DNA translocase FtsK 904602 ftsK 7141926 ftsK Escherichia coli ED1a DNA translocase FtsK YP_002396890.1 900535 D 585397 CDS YP_002396891.1 218688679 7142193 904758..905372 1 NC_011745.1 participates with LolB in the incorporation of lipoprotein into the outer membrane; outer-membrane lipoprotein carrier protein 905372 lolA 7142193 lolA Escherichia coli ED1a outer-membrane lipoprotein carrier protein YP_002396891.1 904758 D 585397 CDS YP_002396892.1 218688680 7141900 905383..906726 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7567469, 7628437, 11459952, 11029431; Product type cp : cell process; recombination factor protein RarA 906726 ycaJ 7141900 ycaJ Escherichia coli ED1a recombination factor protein RarA YP_002396892.1 905383 D 585397 CDS YP_002396893.1 218688681 7142702 906817..908109 1 NC_011745.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 908109 serS 7142702 serS Escherichia coli ED1a seryl-tRNA synthetase YP_002396893.1 906817 D 585397 CDS YP_002396894.1 218688682 7141400 complement(909097..909399) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative transcriptional activator from prophage 909399 7141400 ECED1_0868 Escherichia coli ED1a putative transcriptional activator from prophage YP_002396894.1 909097 R 585397 CDS YP_002396895.1 218688683 7141863 complement(909444..910568) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; late control gene D protein from prophage 910568 D 7141863 D Escherichia coli ED1a late control gene D protein from prophage YP_002396895.1 909444 R 585397 CDS YP_002396896.1 218688684 7143050 910723..911910 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 1825255; Product type h : extrachromosomal origin; major tail sheath protein FI from bacteriophage 911910 FI 7143050 FI Escherichia coli ED1a major tail sheath protein FI from bacteriophage YP_002396896.1 910723 D 585397 CDS YP_002396897.1 218688685 7144175 911910..912419 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; major tail sheath protein FII from prophage 912419 FII 7144175 FII Escherichia coli ED1a major tail sheath protein FII from prophage YP_002396897.1 911910 D 585397 CDS YP_002396898.1 218688686 7144179 912467..912856 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage tail protein 912856 7144179 ECED1_0872 Escherichia coli ED1a putative phage tail protein YP_002396898.1 912467 D 585397 CDS YP_002396899.1 218688687 7140939 912968..915796 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative tail protein from prophage; putative tail length tape measure motif 915796 7140939 ECED1_0873 Escherichia coli ED1a putative tail protein from prophage; putative tail length tape measure motif YP_002396899.1 912968 D 585397 CDS YP_002396900.1 218688688 7141021 915762..916298 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative tail protein 916298 7141021 ECED1_0874 Escherichia coli ED1a putative tail protein YP_002396900.1 915762 D 585397 CDS YP_002396901.1 218688689 7141022 complement(916309..916896) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 916896 7141022 ECED1_0875 Escherichia coli ED1a hypothetical protein YP_002396901.1 916309 R 585397 CDS YP_002396902.1 218688690 7141023 complement(916908..918248) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage tail fiber protein 918248 7141023 ECED1_0877 Escherichia coli ED1a putative phage tail fiber protein YP_002396902.1 916908 R 585397 CDS YP_002396903.1 218688691 7141024 complement(918248..918880) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail protein I (GpI) from prophage 918880 I 7141024 I Escherichia coli ED1a tail protein I (GpI) from prophage YP_002396903.1 918248 R 585397 CDS YP_002396904.1 218688692 7140211 complement(918864..919760) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Baseplate assembly protein GpJ from prophage 919760 J 7140211 J Escherichia coli ED1a Baseplate assembly protein GpJ from prophage YP_002396904.1 918864 R 585397 CDS YP_002396905.1 218688693 7142478 complement(919747..920112) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Baseplate assembly protein GpW from prophage 920112 W 7142478 W Escherichia coli ED1a Baseplate assembly protein GpW from prophage YP_002396905.1 919747 R 585397 CDS YP_002396906.1 218688694 7139169 complement(920109..920705) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Baseplate assembly protein GpV from prophage 920705 V 7139169 V Escherichia coli ED1a Baseplate assembly protein GpV from prophage YP_002396906.1 920109 R 585397 CDS YP_002396907.1 218688695 7139161 complement(920687..921433) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage tail completion protein S 921433 7139161 ECED1_0882 Escherichia coli ED1a putative phage tail completion protein S YP_002396907.1 920687 R 585397 CDS YP_002396908.1 218688696 7141025 complement(921315..921782) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; phage tail completion protein R 921782 R 7141025 R Escherichia coli ED1a phage tail completion protein R YP_002396908.1 921315 R 585397 CDS YP_002396909.1 218688697 7141247 921795..921968 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 921968 7141247 ECED1_0884 Escherichia coli ED1a hypothetical protein YP_002396909.1 921795 D 585397 CDS YP_002396910.1 218688698 7141026 complement(922118..924184) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 924184 7141026 ECED1_0885 Escherichia coli ED1a hypothetical protein YP_002396910.1 922118 R 585397 CDS YP_002396911.1 218688699 7141027 complement(924174..924503) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 924503 7141027 ECED1_0886 Escherichia coli ED1a hypothetical protein YP_002396911.1 924174 R 585397 CDS YP_002396912.1 218688700 7141028 complement(924292..924744) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 924744 7141028 ECED1_0887 Escherichia coli ED1a hypothetical protein YP_002396912.1 924292 R 585397 CDS YP_002396913.1 218688701 7141029 complement(924714..925265) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; prophage lysozyme 925265 lys 7141029 lys Escherichia coli ED1a prophage lysozyme YP_002396913.1 924714 R 585397 CDS YP_002396914.1 218688702 7141930 complement(925243..925539) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 925539 7141930 ECED1_0889 Escherichia coli ED1a hypothetical protein YP_002396914.1 925243 R 585397 CDS YP_002396915.1 218688703 7141030 complement(925530..925799) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail protein X from prophage 925799 X 7141030 X Escherichia coli ED1a tail protein X from prophage YP_002396915.1 925530 R 585397 CDS YP_002396916.1 218688704 7139197 complement(925730..926224) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage head completion protein L 926224 7139197 ECED1_0891 Escherichia coli ED1a putative phage head completion protein L YP_002396916.1 925730 R 585397 CDS YP_002396917.1 218688705 7141031 complement(926329..927126) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage terminase (endonuclease subunit) 927126 7141031 ECED1_0892 Escherichia coli ED1a putative phage terminase (endonuclease subunit) YP_002396917.1 926329 R 585397 CDS YP_002396918.1 218688706 7141032 complement(927167..928267) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; capsid proteins (GpN) 928267 N 7141032 N Escherichia coli ED1a capsid proteins (GpN) YP_002396918.1 927167 R 585397 CDS YP_002396919.1 218688707 7140326 complement(928285..929154) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative capsid scaffolding protein (GpO) 929154 7140326 ECED1_0894 Escherichia coli ED1a putative capsid scaffolding protein (GpO) YP_002396919.1 928285 R 585397 CDS YP_002396920.1 218688708 7141033 929172..931010 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; terminase, ATPase subunit (GpP) 931010 P 7141033 P Escherichia coli ED1a terminase, ATPase subunit (GpP) YP_002396920.1 929172 D 585397 CDS YP_002396921.1 218688709 7139996 931132..932058 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative portal vertex protein (GpQ) from prophage 932058 7139996 ECED1_0896 Escherichia coli ED1a putative portal vertex protein (GpQ) from prophage YP_002396921.1 931132 D 585397 CDS YP_002396922.1 218688710 7141034 complement(932124..932627) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 932627 7141034 ECED1_0897 Escherichia coli ED1a hypothetical protein YP_002396922.1 932124 R 585397 CDS YP_002396923.1 218688711 7141035 complement(932733..932906) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 932906 7141035 ECED1_0898 Escherichia coli ED1a hypothetical protein YP_002396923.1 932733 R 585397 CDS YP_002396924.1 218688712 7141036 complement(933759..933941) 1 NC_011745.1 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin; Single-stranded DNA-binding protein (fragment) 933941 7141036 ECED1_0899 Escherichia coli ED1a Single-stranded DNA-binding protein (fragment) YP_002396924.1 933759 R 585397 CDS YP_002396925.1 218688713 7141037 934069..934371 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS600 934371 insM 7141037 insM Escherichia coli ED1a transposase ORF A, IS600 YP_002396925.1 934069 D 585397 CDS YP_002396926.1 218688714 7141163 934407..935225 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS600 935225 7141163 ECED1_0901 Escherichia coli ED1a transposase ORF B, IS600 YP_002396926.1 934407 D 585397 CDS YP_002396927.1 218688715 7141038 complement(935376..935783) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Protein ren (modular protein) from prophage 935783 ren 7141038 ren Escherichia coli ED1a Protein ren (modular protein) from prophage YP_002396927.1 935376 R 585397 CDS YP_002396928.1 218688716 7141588 complement(935711..935920) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 935920 7141588 ECED1_0903 Escherichia coli ED1a hypothetical protein YP_002396928.1 935711 R 585397 CDS YP_002396929.1 218688717 7141039 complement(935930..936334) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 936334 7141039 ECED1_0904 Escherichia coli ED1a hypothetical protein YP_002396929.1 935930 R 585397 CDS YP_002396930.1 218688718 7141040 complement(936331..938853) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative endonuclease from prophage, replication protein A (GpA) 938853 7141040 ECED1_0905 Escherichia coli ED1a putative endonuclease from prophage, replication protein A (GpA) YP_002396930.1 936331 R 585397 CDS YP_002396931.1 218688719 7141041 complement(938841..939257) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 939257 7141041 ECED1_0906 Escherichia coli ED1a hypothetical protein YP_002396931.1 938841 R 585397 CDS YP_002396932.1 218688720 7141042 complement(939326..939547) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 939547 7141042 ECED1_0907 Escherichia coli ED1a hypothetical protein YP_002396932.1 939326 R 585397 CDS YP_002396933.1 218688721 7141043 939748..940395 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 940395 7141043 ECED1_0908 Escherichia coli ED1a hypothetical protein YP_002396933.1 939748 D 585397 CDS YP_002396934.1 218688722 7141044 complement(940369..940719) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 940719 7141044 ECED1_0909 Escherichia coli ED1a hypothetical protein YP_002396934.1 940369 R 585397 CDS YP_002396935.1 218688723 7141045 complement(940710..940928) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 940928 7141045 ECED1_0910 Escherichia coli ED1a hypothetical protein YP_002396935.1 940710 R 585397 CDS YP_002396936.1 218688724 7141046 complement(940925..941161) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 941161 7141046 ECED1_0911 Escherichia coli ED1a hypothetical protein YP_002396936.1 940925 R 585397 CDS YP_002396937.1 218688725 7141047 complement(941197..942177) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; DNA adenine methylase from prophage 942177 dam 7141047 dam Escherichia coli ED1a DNA adenine methylase from prophage YP_002396937.1 941197 R 585397 CDS YP_002396938.1 218688726 7143058 complement(942193..942381) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 942381 7143058 ECED1_0913 Escherichia coli ED1a hypothetical protein YP_002396938.1 942193 R 585397 CDS YP_002396939.1 218688727 7141048 complement(942411..943001) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative ribonuclease (polynucleotidyl transferase) from prophage 943001 7141048 ECED1_0914 Escherichia coli ED1a putative ribonuclease (polynucleotidyl transferase) from prophage YP_002396939.1 942411 R 585397 CDS YP_002396940.1 218688728 7141049 complement(942992..943264) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 943264 7141049 ECED1_0915 Escherichia coli ED1a hypothetical protein YP_002396940.1 942992 R 585397 CDS YP_002396941.1 218688729 7141050 complement(943559..943801) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 943801 7141050 ECED1_0916 Escherichia coli ED1a hypothetical protein YP_002396941.1 943559 R 585397 CDS YP_002396942.1 218688730 7141051 943976..944143 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 944143 7141051 ECED1_0917 Escherichia coli ED1a hypothetical protein YP_002396942.1 943976 D 585397 CDS YP_002396943.1 218688731 7141052 complement(944317..944694) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 944694 7141052 ECED1_0918 Escherichia coli ED1a hypothetical protein YP_002396943.1 944317 R 585397 CDS YP_002396944.1 218688732 7141053 944581..945036 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 945036 7141053 ECED1_0919 Escherichia coli ED1a hypothetical protein YP_002396944.1 944581 D 585397 CDS YP_002396945.1 218688733 7141054 complement(945018..945362) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 945362 7141054 ECED1_0920 Escherichia coli ED1a hypothetical protein YP_002396945.1 945018 R 585397 CDS YP_002396946.1 218688734 7141055 complement(945121..945645) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 945645 7141055 ECED1_0921 Escherichia coli ED1a hypothetical protein YP_002396946.1 945121 R 585397 CDS YP_002396947.1 218688735 7141056 945608..946090 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; repressor protein C (modular protein) from prophage 946090 C 7141056 C Escherichia coli ED1a repressor protein C (modular protein) from prophage YP_002396947.1 945608 D 585397 CDS YP_002396948.1 218688736 7140470 946145..947152 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Integrase 947152 int 7140470 int Escherichia coli ED1a Integrase YP_002396948.1 946145 D 585397 CDS YP_002396949.1 218688737 7141172 947452..949896 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91008971, 92011349, 94171715, 10801884, 3062312; Product type e : enzyme; dimethyl sulfoxide reductase, anaerobic subunit A 949896 dmsA 7141172 dmsA Escherichia coli ED1a dimethyl sulfoxide reductase, anaerobic subunit A YP_002396949.1 947452 D 585397 CDS YP_002396950.1 218688738 7140498 949907..950524 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91070067, 91355180, 92011349, 3062312; Product type e : enzyme; dimethyl sulfoxide reductase, anaerobic subunit B 950524 dmsB 7140498 dmsB Escherichia coli ED1a dimethyl sulfoxide reductase, anaerobic subunit B YP_002396950.1 949907 D 585397 CDS YP_002396951.1 218688739 7140499 950526..951389 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91008971, 92011349, 3062312, 8429002; Product type e : enzyme; dimethyl sulfoxide reductase, anaerobic subunit C 951389 dmsC 7140499 dmsC Escherichia coli ED1a dimethyl sulfoxide reductase, anaerobic subunit C YP_002396951.1 950526 D 585397 CDS YP_002396952.1 218688740 7140500 complement(951425..952051) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9782055, 3062312, 11714269; Product type pe : putative enzyme; putative hydrolase 952051 ycaC 7140500 ycaC Escherichia coli ED1a putative hydrolase YP_002396952.1 951425 R 585397 CDS YP_002396953.1 218688741 7142699 952365..953513 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS family transporter protein 953513 ycaD 7142699 ycaD Escherichia coli ED1a putative MFS family transporter protein YP_002396953.1 952365 D 585397 CDS YP_002396954.1 218688742 7142700 complement(953610..954350) 1 NC_011745.1 activates pyruvate formate-lyase 1 under anaerobic conditions; pyruvate formate lyase-activating enzyme 1 954350 pflA 7142700 pflA Escherichia coli ED1a pyruvate formate lyase-activating enzyme 1 YP_002396954.1 953610 R 585397 CDS YP_002396955.1 218688743 7144069 complement(954542..956824) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91064082, 92276323, 10504733, 1310545, 2651404, 3053170, 9629924; Product type e : enzyme; pyruvate formate lyase I 956824 pflB 7144069 pflB Escherichia coli ED1a pyruvate formate lyase I YP_002396955.1 954542 R 585397 CDS YP_002396956.1 218688744 7144070 complement(956879..957736) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94293770, 2651404; Product type t : transporter; formate transporter 957736 focA 7144070 focA Escherichia coli ED1a formate transporter YP_002396956.1 956879 R 585397 CDS YP_002396957.1 218688745 7142154 complement(958142..959902) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 959902 ycaO 7142154 ycaO Escherichia coli ED1a hypothetical protein YP_002396957.1 958142 R 585397 CDS YP_002396958.1 218688746 7142704 960032..960724 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 960724 ycaP 7142704 ycaP Escherichia coli ED1a hypothetical protein YP_002396958.1 960032 D 585397 CDS YP_002396959.1 218688747 7142705 960923..962011 1 NC_011745.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase 962011 serC 7142705 serC Escherichia coli ED1a phosphoserine aminotransferase YP_002396959.1 960923 D 585397 CDS YP_002396960.1 218688748 7141399 962082..963365 1 NC_011745.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 963365 aroA 7141399 aroA Escherichia coli ED1a 3-phosphoshikimate 1-carboxyvinyltransferase YP_002396960.1 962082 D 585397 CDS YP_002396961.1 218688749 7142623 963535..964299 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative lipoprotein with metallohydrolase domain 964299 ycaL 7142623 ycaL Escherichia coli ED1a putative lipoprotein with metallohydrolase domain YP_002396961.1 963535 D 585397 CDS YP_002396962.1 218688750 7142703 964472..965155 1 NC_011745.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 965155 cmk 7142703 cmk Escherichia coli ED1a cytidylate kinase YP_002396962.1 964472 D 585397 CDS YP_002396963.1 218688751 7139380 965266..966939 1 NC_011745.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 966939 rpsA 7139380 rpsA Escherichia coli ED1a 30S ribosomal protein S1 YP_002396963.1 965266 D 585397 CDS YP_002396964.1 218688752 7140084 967099..967383 1 NC_011745.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit beta 967383 ihfB 7140084 ihfB Escherichia coli ED1a integration host factor subunit beta YP_002396964.1 967099 D 585397 CDS YP_002396965.1 218688753 7140233 967589..969853 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 969853 ycaI 7140233 ycaI Escherichia coli ED1a hypothetical protein YP_002396965.1 967589 D 585397 CDS YP_002396966.1 218688754 7142701 969890..971638 1 NC_011745.1 involved in the transport of lipid A across the inner membrane; lipid transporter ATP-binding/permease 971638 msbA 7142701 msbA Escherichia coli ED1a lipid transporter ATP-binding/permease YP_002396966.1 969890 D 585397 CDS YP_002396967.1 218688755 7139030 971635..972621 1 NC_011745.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate; tetraacyldisaccharide 4'-kinase 972621 lpxK 7139030 lpxK Escherichia coli ED1a tetraacyldisaccharide 4'-kinase YP_002396967.1 971635 D 585397 CDS YP_002396968.1 218688756 7141922 972658..973764 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 973764 ycaQ 7141922 ycaQ Escherichia coli ED1a hypothetical protein YP_002396968.1 972658 D 585397 CDS YP_002396969.1 218688757 7142706 complement(973761..974579) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS600 974579 7142706 ECED1_0944 Escherichia coli ED1a transposase ORF B, IS600 YP_002396969.1 973761 R 585397 CDS YP_002396970.1 218688758 7141057 complement(974615..974917) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS600 974917 insM 7141057 insM Escherichia coli ED1a transposase ORF A, IS600 YP_002396970.1 974615 R 585397 CDS YP_002396971.1 218688759 7141164 974933..975157 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 975157 ycaQ 7141164 ycaQ Escherichia coli ED1a hypothetical protein YP_002396971.1 974933 D 585397 CDS YP_002396972.1 218688760 7142707 975209..975391 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 975391 ycaR 7142707 ycaR Escherichia coli ED1a hypothetical protein YP_002396972.1 975209 D 585397 CDS YP_002396973.1 218688761 7142708 975388..976134 1 NC_011745.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 976134 kdsB 7142708 kdsB Escherichia coli ED1a 3-deoxy-manno-octulosonate cytidylyltransferase YP_002396973.1 975388 D 585397 CDS YP_002396974.1 218688762 7142499 976288..977181 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 977181 ycbJ 7142499 ycbJ Escherichia coli ED1a hypothetical protein YP_002396974.1 976288 D 585397 CDS YP_002396975.1 218688763 7142712 complement(977158..977937) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 977937 ycbC 7142712 ycbC Escherichia coli ED1a hypothetical protein YP_002396975.1 977158 R 585397 CDS YP_002396976.1 218688764 7142710 978073..978858 1 NC_011745.1 involved in cellular zinc and cadmium homeostasis by binding excess metal ions to its cysteine sulfurs and histidine nitrogens; expression of smtA in cyanobacteria is repressed by SmtB at low concentrations of zinc; NO elicits release of Zn ions from SmtA; putative metallothionein SmtA 978858 smtA 7142710 smtA Escherichia coli ED1a putative metallothionein SmtA YP_002396976.1 978073 D 585397 CDS YP_002396977.1 218688765 7143813 978855..980177 1 NC_011745.1 acts with MukB and MukE to condense the chromosome and allow for segregation during cell division; condesin subunit F 980177 mukF 7143813 mukF Escherichia coli ED1a condesin subunit F YP_002396977.1 978855 D 585397 CDS YP_002396978.1 218688766 7139044 980185..980862 1 NC_011745.1 acts with MukB and MukF to condense the chromosome and allow for segregation during cell division; condesin subunit E 980862 mukE 7139044 mukE Escherichia coli ED1a condesin subunit E YP_002396978.1 980185 D 585397 CDS YP_002396979.1 218688767 7139043 980862..985322 1 NC_011745.1 SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects; cell division protein MukB 985322 mukB 7139043 mukB Escherichia coli ED1a cell division protein MukB YP_002396979.1 980862 D 585397 CDS YP_002396980.1 218688768 7139042 985583..987430 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 987430 ycbB 7139042 ycbB Escherichia coli ED1a hypothetical protein YP_002396980.1 985583 D 585397 CDS YP_002396981.1 218688769 7142709 987611..988159 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 988159 ycbK 7142709 ycbK Escherichia coli ED1a hypothetical protein YP_002396981.1 987611 D 585397 CDS YP_002396982.1 218688770 7142713 988186..988833 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14529289; Product type pe : putative enzyme; putative metal-binding hydrolase 988833 ycbL 7142713 ycbL Escherichia coli ED1a putative metal-binding hydrolase YP_002396982.1 988186 D 585397 CDS YP_002396983.1 218688771 7142714 complement(988883..990073) 1 NC_011745.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 990073 aspC 7142714 aspC Escherichia coli ED1a aromatic amino acid aminotransferase YP_002396983.1 988883 R 585397 CDS YP_002396984.1 218688772 7142650 complement(990258..991346) 1 NC_011745.1 outer membrane porin F; 1a; Ia; b; outer membrane protein F 991346 ompF 7142650 ompF Escherichia coli ED1a outer membrane protein F YP_002396984.1 990258 R 585397 CDS YP_002396985.1 218688773 7139969 complement(991949..993349) 1 NC_011745.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase 993349 asnC 7139969 asnC Escherichia coli ED1a asparaginyl-tRNA synthetase YP_002396985.1 991949 R 585397 CDS YP_002396986.1 218688774 7142648 complement(993518..994720) 1 NC_011745.1 catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 994720 pncB 7142648 pncB Escherichia coli ED1a nicotinate phosphoribosyltransferase YP_002396986.1 993518 R 585397 CDS YP_002396987.1 218688775 7139076 994986..997598 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21101837, 86164315, 87163509, 2436977, 3018440; Product type e : enzyme; aminopeptidase N 997598 pepN 7139076 pepN Escherichia coli ED1a aminopeptidase N YP_002396987.1 994986 D 585397 CDS YP_002396988.1 218688776 7144062 complement(997641..998408) 1 NC_011745.1 part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic substrate-binding subunit, SsuB the ATP-binding subunit and SsuC the permease; aliphatic sulfonates transport ATP-binding subunit 998408 ssuB 7144062 ssuB Escherichia coli ED1a aliphatic sulfonates transport ATP-binding subunit YP_002396988.1 997641 R 585397 CDS YP_002396989.1 218688777 7143857 complement(998405..999196) 1 NC_011745.1 part of the ABC type transport system for alkanesulfonate SsuABC; SsuB the ATP-binding subunit and SsuC the permease; alkanesulfonate transporter permease subunit 999196 ssuC 7143857 ssuC Escherichia coli ED1a alkanesulfonate transporter permease subunit YP_002396989.1 998405 R 585397 CDS YP_002396990.1 218688778 7143858 complement(999208..1000353) 1 NC_011745.1 catalyzes the release of sulfite from alkanesulfonates; alkanesulfonate monooxygenase 1000353 ssuD 7143858 ssuD Escherichia coli ED1a alkanesulfonate monooxygenase YP_002396990.1 999208 R 585397 CDS YP_002396991.1 218688779 7143859 complement(1000350..1001309) 1 NC_011745.1 part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic subunit SsuB the ATP-binding subunit and SsuC the permease; alkanesulfonate transporter substrate-binding subunit 1001309 ssuA 7143859 ssuA Escherichia coli ED1a alkanesulfonate transporter substrate-binding subunit YP_002396991.1 1000350 R 585397 CDS YP_002396992.1 218688780 7143856 complement(1001302..1001877) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20245523, 99410391, 99436146, 8774726; Product type e : enzyme; NAD(P)H-dependent FMN reductase 1001877 ssuE 7143856 ssuE Escherichia coli ED1a NAD(P)H-dependent FMN reductase YP_002396992.1 1001302 R 585397 CDS YP_002396993.1 218688781 7143860 1002114..1003124 1 NC_011745.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 1003124 pyrD 7143860 pyrD Escherichia coli ED1a dihydroorotate dehydrogenase 2 YP_002396993.1 1002114 D 585397 CDS YP_002396994.1 218688782 7141233 1003298..1003840 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1003840 ycbW 7141233 ycbW Escherichia coli ED1a hypothetical protein YP_002396994.1 1003298 D 585397 CDS YP_002396995.1 218688783 7142715 complement(1003837..1004946) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1327782; Product type pe : putative enzyme; putative 2Fe-2S cluster-containing protein 1004946 ycbX 7142715 ycbX Escherichia coli ED1a putative 2Fe-2S cluster-containing protein YP_002396995.1 1003837 R 585397 CDS YP_002396996.1 218688784 7142716 1005044..1007152 1 NC_011745.1 catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA; 23S rRNA m(2)G2445 methyltransferase 1007152 rlmL 7142716 rlmL Escherichia coli ED1a 23S rRNA m(2)G2445 methyltransferase YP_002396996.1 1005044 D 585397 CDS YP_002396997.1 218688785 7142717 1007164..1009071 1 NC_011745.1 Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth; ABC transporter ATPase 1009071 uup 7142717 uup Escherichia coli ED1a ABC transporter ATPase YP_002396997.1 1007164 D 585397 CDS YP_002396998.1 218688786 7139149 1009201..1010454 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95270582; Product type cp : cell process; paraquat-inducible membrane protein A 1010454 pqiA 7139149 pqiA Escherichia coli ED1a paraquat-inducible membrane protein A YP_002396998.1 1009201 D 585397 CDS YP_002396999.1 218688787 7139111 1010459..1012099 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95270582; Product type cp : cell process; paraquat-inducible protein B 1012099 pqiB 7139111 pqiB Escherichia coli ED1a paraquat-inducible protein B YP_002396999.1 1010459 D 585397 CDS YP_002397000.1 218688788 7139112 1012111..1012659 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1012659 ymbA 7139112 ymbA Escherichia coli ED1a hypothetical protein YP_002397000.1 1012111 D 585397 CDS YP_002397001.1 218688789 7140972 1012915..1013082 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1101029, 90207255, 2832401, 8440252; Product type f : factor; ribosome modulation factor 1013082 rmf 7140972 rmf Escherichia coli ED1a ribosome modulation factor YP_002397001.1 1012915 D 585397 CDS YP_002397002.1 218688790 7141428 complement(1013152..1013670) 1 NC_011745.1 catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP; 3-hydroxydecanoyl-(acyl carrier protein) dehydratase 1013670 fabA 7141428 fabA Escherichia coli ED1a 3-hydroxydecanoyl-(acyl carrier protein) dehydratase YP_002397002.1 1013152 R 585397 CDS YP_002397003.1 218688791 7139837 complement(1013739..1015499) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ATP-dependent protease 1015499 ycbZ 7139837 ycbZ Escherichia coli ED1a putative ATP-dependent protease YP_002397003.1 1013739 R 585397 CDS YP_002397004.1 218688792 7142718 1015685..1016137 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1016137 ycbG 7142718 ycbG Escherichia coli ED1a hypothetical protein YP_002397004.1 1015685 D 585397 CDS YP_002397005.1 218688793 7142711 complement(1016215..1017255) 1 NC_011745.1 OmpA is believed to be a porin, involved in diffusion of nonspecific small solutes across the outer membrane. It is the most abundant integral protein of the outer membrane of E. coli, and it is known to play a role as a phage receptor, a mediator of F-factor dependent conjugation, and in maintaining the structural shape of the outer membrane; 3a; II*; G; d; outer membrane protein A 1017255 ompA 7142711 ompA Escherichia coli ED1a outer membrane protein A YP_002397005.1 1016215 R 585397 CDS YP_002397006.1 218688794 7142461 complement(1017611..1018120) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10368140, 91072263, 93163041, 98348458, 3297925, 6253901, 6306396; Product type cp : cell process; SOS cell division inhibitor 1018120 sulA 7142461 sulA Escherichia coli ED1a SOS cell division inhibitor YP_002397006.1 1017611 R 585397 CDS YP_002397007.1 218688795 7141499 1018339..1018968 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1018968 yccR 7141499 yccR Escherichia coli ED1a hypothetical protein YP_002397007.1 1018339 D 585397 CDS YP_002397008.1 218688796 7142723 complement(1018931..1021084) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1021084 yccS 7142723 yccS Escherichia coli ED1a hypothetical protein YP_002397008.1 1018931 R 585397 CDS YP_002397009.1 218688797 7142724 complement(1021103..1021549) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1021549 yccF 7142724 yccF Escherichia coli ED1a hypothetical protein YP_002397009.1 1021103 R 585397 CDS YP_002397010.1 218688798 7142720 1021672..1023726 1 NC_011745.1 catalyzes the ATP-dependent unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand; DNA helicase IV 1023726 helD 7142720 helD Escherichia coli ED1a DNA helicase IV YP_002397010.1 1021672 D 585397 CDS YP_002397011.1 218688799 7139864 complement(1023758..1024216) 1 NC_011745.1 catalyzes the formation of methylglyoxal from glycerone phosphate; methylglyoxal synthase 1024216 mgsA 7139864 mgsA Escherichia coli ED1a methylglyoxal synthase YP_002397011.1 1023758 R 585397 CDS YP_002397012.1 218688800 7142267 complement(1024312..1024974) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1024974 yccT 7142267 yccT Escherichia coli ED1a hypothetical protein YP_002397012.1 1024312 R 585397 CDS YP_002397013.1 218688801 7142725 1025147..1025560 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative CoA-binding protein 1025560 yccU 7142725 yccU Escherichia coli ED1a putative CoA-binding protein YP_002397013.1 1025147 D 585397 CDS YP_002397014.1 218688802 7142726 complement(1025605..1025922) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12700277, 15569148; Product type f : factor; heat shock protein HspQ 1025922 yccV 7142726 yccV Escherichia coli ED1a heat shock protein HspQ YP_002397014.1 1025605 R 585397 CDS YP_002397015.1 218688803 7142727 complement(1025980..1027083) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative AdoMet-dependent methyltransferase 1027083 yccW 7142727 yccW Escherichia coli ED1a putative AdoMet-dependent methyltransferase YP_002397015.1 1025980 R 585397 CDS YP_002397016.1 218688804 7142728 1027052..1027543 1 NC_011745.1 catalyzes the hydrolysis of acylphosphate; acylphosphatase 1027543 yccX 7142728 yccX Escherichia coli ED1a acylphosphatase YP_002397016.1 1027052 D 585397 CDS YP_002397017.1 218688805 7142729 complement(1027540..1027869) 1 NC_011745.1 transfers sulfur from TusBCD complex to MnmA; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein TusE 1027869 tusE 7142729 tusE Escherichia coli ED1a sulfur transfer protein TusE YP_002397017.1 1027540 R 585397 CDS YP_002397018.1 218688806 7140849 complement(1027961..1028620) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6376117; Product type m : membrane component; hypothetical protein 1028620 yccA 7140849 yccA Escherichia coli ED1a hypothetical protein YP_002397018.1 1027961 R 585397 CDS YP_002397019.1 218688807 7142719 complement(1029028..1030047) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative integrase from prophage 1030047 7142719 ECED1_0994 Escherichia coli ED1a putative integrase from prophage YP_002397019.1 1029028 R 585397 CDS YP_002397020.1 218688808 7141058 complement(1030025..1030267) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1030267 7141058 ECED1_0995 Escherichia coli ED1a hypothetical protein YP_002397020.1 1030025 R 585397 CDS YP_002397021.1 218688809 7141059 complement(1030335..1032806) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative exonuclease from phage origin 1032806 7141059 ECED1_0996 Escherichia coli ED1a putative exonuclease from phage origin YP_002397021.1 1030335 R 585397 CDS YP_002397022.1 218688810 7141060 complement(1032901..1033089) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1033089 7141060 ECED1_0997 Escherichia coli ED1a hypothetical protein YP_002397022.1 1032901 R 585397 CDS YP_002397023.1 218688811 7141061 complement(1033086..1033274) 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 3041373; Product type h : extrachromosomal origin; Cell division inhibition protein dicB from bacteriophage origin 1033274 dicB 7141061 dicB Escherichia coli ED1a Cell division inhibition protein dicB from bacteriophage origin YP_002397023.1 1033086 R 585397 CDS YP_002397024.1 218688812 7143116 1033588..1033848 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1033848 7143116 ECED1_0999 Escherichia coli ED1a hypothetical protein YP_002397024.1 1033588 D 585397 CDS YP_002397025.1 218688813 7141062 1033778..1034044 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1034044 7141062 ECED1_1000 Escherichia coli ED1a hypothetical protein YP_002397025.1 1033778 D 585397 CDS YP_002397026.1 218688814 7141063 complement(1034033..1034383) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1034383 7141063 ECED1_1001 Escherichia coli ED1a hypothetical protein YP_002397026.1 1034033 R 585397 CDS YP_002397027.1 218688815 7141064 complement(1034383..1034616) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1034616 ydfA 7141064 ydfA Escherichia coli ED1a hypothetical protein YP_002397027.1 1034383 R 585397 CDS YP_002397028.1 218688816 7139257 complement(1034810..1035100) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative plasmid stabilization-like protein from prophage 1035100 7139257 ECED1_1003 Escherichia coli ED1a putative plasmid stabilization-like protein from prophage YP_002397028.1 1034810 R 585397 CDS YP_002397029.1 218688817 7141065 complement(1035100..1035291) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1035291 7141065 ECED1_1004 Escherichia coli ED1a hypothetical protein YP_002397029.1 1035100 R 585397 CDS YP_002397030.1 218688818 7141066 complement(1035309..1035809) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative regulator of the C1 family from prophage 1035809 7141066 ECED1_1005 Escherichia coli ED1a putative regulator of the C1 family from prophage YP_002397030.1 1035309 R 585397 CDS YP_002397031.1 218688819 7141067 1035917..1036180 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative regulator of the C1 family (possibly fragment) 1036180 7141067 ECED1_1006 Escherichia coli ED1a putative regulator of the C1 family (possibly fragment) YP_002397031.1 1035917 D 585397 CDS YP_002397032.1 218688820 7141068 1036177..1036602 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1036602 7141068 ECED1_1007 Escherichia coli ED1a hypothetical protein YP_002397032.1 1036177 D 585397 CDS YP_002397033.1 218688821 7141069 1036610..1037587 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage replication protein O (weak confidence) 1037587 7141069 ECED1_1008 Escherichia coli ED1a putative phage replication protein O (weak confidence) YP_002397033.1 1036610 D 585397 CDS YP_002397034.1 218688822 7141070 1037594..1038340 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative replication protein 1038340 ydaV 7141070 ydaV Escherichia coli ED1a putative replication protein YP_002397034.1 1037594 D 585397 CDS YP_002397035.1 218688823 7142015 1038362..1039132 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1039132 7142015 ECED1_1010 Escherichia coli ED1a hypothetical protein YP_002397035.1 1038362 D 585397 CDS YP_002397036.1 218688824 7141071 1039133..1039570 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1039570 7141071 ECED1_1011 Escherichia coli ED1a hypothetical protein YP_002397036.1 1039133 D 585397 CDS YP_002397037.1 218688825 7141072 1039738..1040376 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative NUDIX hydrolase 1040376 7141072 ECED1_1012 Escherichia coli ED1a putative NUDIX hydrolase YP_002397037.1 1039738 D 585397 CDS YP_002397038.1 218688826 7141073 1040400..1041044 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative 2-deoxyglucose-6-phosphatase 1041044 7141073 ECED1_1013 Escherichia coli ED1a putative 2-deoxyglucose-6-phosphatase YP_002397038.1 1040400 D 585397 CDS YP_002397039.1 218688827 7141074 complement(1041045..1041233) 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 1041233 7141074 ECED1_1014 Escherichia coli ED1a hypothetical protein YP_002397039.1 1041045 R 585397 CDS YP_002397040.1 218688828 7141076 1042212..1043261 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1043261 ydfU 7141076 ydfU Escherichia coli ED1a hypothetical protein YP_002397040.1 1042212 D 585397 CDS YP_002397041.1 218688829 7139269 1043267..1043467 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 1043467 7139269 ECED1_1017 Escherichia coli ED1a hypothetical protein YP_002397041.1 1043267 D 585397 CDS YP_002397042.1 218688830 7141077 1043274..1043633 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative crossover junction endodeoxyribonuclease RusA 1043633 7141077 ECED1_1018 Escherichia coli ED1a putative crossover junction endodeoxyribonuclease RusA YP_002397042.1 1043274 D 585397 CDS YP_002397043.1 218688831 7141078 1043630..1044202 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1044202 7141078 ECED1_1019 Escherichia coli ED1a hypothetical protein YP_002397043.1 1043630 D 585397 CDS YP_002397044.1 218688832 7141079 1044297..1044617 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1044617 7141079 ECED1_1020 Escherichia coli ED1a hypothetical protein YP_002397044.1 1044297 D 585397 CDS YP_002397045.1 218688833 7141080 1044768..1045826 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative DNA adenine methyltransferase ( DNA methylase) from phage origin 1045826 7141080 ECED1_1021 Escherichia coli ED1a putative DNA adenine methyltransferase ( DNA methylase) from phage origin YP_002397045.1 1044768 D 585397 CDS YP_002397046.1 218688834 7140781 1046684..1048666 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1048666 7140781 ECED1_1022 Escherichia coli ED1a hypothetical protein YP_002397046.1 1046684 D 585397 CDS YP_002397047.1 218688835 7141082 1048620..1048793 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1048793 7141082 ECED1_1023 Escherichia coli ED1a hypothetical protein YP_002397047.1 1048620 D 585397 CDS YP_002397048.1 218688836 7141083 1048852..1049316 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1049316 7141083 ECED1_1024 Escherichia coli ED1a hypothetical protein YP_002397048.1 1048852 D 585397 CDS YP_002397049.1 218688837 7141084 1049392..1049607 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage lysis protein S 1049607 essD 7141084 essD Escherichia coli ED1a putative phage lysis protein S YP_002397049.1 1049392 D 585397 CDS YP_002397050.1 218688838 7139811 1049612..1050247 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1050247 7139811 ECED1_1026 Escherichia coli ED1a hypothetical protein YP_002397050.1 1049612 D 585397 CDS YP_002397051.1 218688839 7141085 complement(1050195..1050680) 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 1050680 7141085 ECED1_1027 Escherichia coli ED1a hypothetical protein YP_002397051.1 1050195 R 585397 CDS YP_002397052.1 218688840 7141086 1050567..1051100 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-associated lysozyme; Qin prophage 1051100 ydfQ 7141086 ydfQ Escherichia coli ED1a putative membrane-associated lysozyme; Qin prophage YP_002397052.1 1050567 D 585397 CDS YP_002397053.1 218688841 7139263 1051224..1051439 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1051439 7139263 ECED1_1029 Escherichia coli ED1a hypothetical protein YP_002397053.1 1051224 D 585397 CDS YP_002397054.1 218688842 7141087 1051364..1051585 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1051585 7141087 ECED1_1030 Escherichia coli ED1a hypothetical protein YP_002397054.1 1051364 D 585397 CDS YP_002397055.1 218688843 7141088 1051582..1052055 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Endopeptidase (Lysis protein) from bacteriophage origin 1052055 rz 7141088 rz Escherichia coli ED1a Endopeptidase (Lysis protein) from bacteriophage origin YP_002397055.1 1051582 D 585397 CDS YP_002397056.1 218688844 7141356 1052079..1052303 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1052303 7141356 ECED1_1032 Escherichia coli ED1a hypothetical protein YP_002397056.1 1052079 D 585397 CDS YP_002397057.1 218688845 7141089 1052758..1053267 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative terminase small subunit (DNA packaging protein Nu1) from bacteriophage origin 1053267 7141089 ECED1_1033 Escherichia coli ED1a putative terminase small subunit (DNA packaging protein Nu1) from bacteriophage origin YP_002397057.1 1052758 D 585397 CDS YP_002397058.1 218688846 7141090 1053182..1055167 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; terminase large subunit (Gp2) 1055167 7141090 ECED1_1034 Escherichia coli ED1a terminase large subunit (Gp2) YP_002397058.1 1053182 D 585397 CDS YP_002397059.1 218688847 7141091 1055151..1055357 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; head stabilization protein 1055357 7141091 ECED1_1035 Escherichia coli ED1a head stabilization protein YP_002397059.1 1055151 D 585397 CDS YP_002397060.1 218688848 7141092 1055354..1056946 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; head protein Gp4 1056946 7141092 ECED1_1036 Escherichia coli ED1a head protein Gp4 YP_002397060.1 1055354 D 585397 CDS YP_002397061.1 218688849 7141093 1056936..1058441 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; head-tail preconnector protein GP5 1058441 7141093 ECED1_1037 Escherichia coli ED1a head-tail preconnector protein GP5 YP_002397061.1 1056936 D 585397 CDS YP_002397062.1 218688850 7141094 1058478..1058825 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; major capsid protein D 1058825 7141094 ECED1_1038 Escherichia coli ED1a major capsid protein D YP_002397062.1 1058478 D 585397 CDS YP_002397063.1 218688851 7141095 1058883..1059911 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; major head protein 1059911 7141095 ECED1_1039 Escherichia coli ED1a major head protein YP_002397063.1 1058883 D 585397 CDS YP_002397064.1 218688852 7141096 1059964..1060332 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative DNA packaging protein from phage origin 1060332 7141096 ECED1_1040 Escherichia coli ED1a putative DNA packaging protein from phage origin YP_002397064.1 1059964 D 585397 CDS YP_002397065.1 218688853 7141097 1060310..1060678 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail attachment protein 1060678 7141097 ECED1_1041 Escherichia coli ED1a tail attachment protein YP_002397065.1 1060310 D 585397 CDS YP_002397066.1 218688854 7141098 1060694..1061227 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein Z (GpZ) 1061227 7141098 ECED1_1042 Escherichia coli ED1a minor tail protein Z (GpZ) YP_002397066.1 1060694 D 585397 CDS YP_002397067.1 218688855 7141099 1061224..1061619 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein U 1061619 7141099 ECED1_1043 Escherichia coli ED1a minor tail protein U YP_002397067.1 1061224 D 585397 CDS YP_002397068.1 218688856 7142827 1061627..1062373 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; major tail protein V 1062373 V 7142827 V Escherichia coli ED1a major tail protein V YP_002397068.1 1061627 D 585397 CDS YP_002397069.1 218688857 7139162 1062377..1062826 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein G 1062826 7139162 ECED1_1045 Escherichia coli ED1a minor tail protein G YP_002397069.1 1062377 D 585397 CDS YP_002397070.1 218688858 7143481 1062853..1063266 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein T 1063266 7143481 ECED1_1046 Escherichia coli ED1a minor tail protein T YP_002397070.1 1062853 D 585397 CDS YP_002397071.1 218688859 7143482 1063247..1065808 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein H 1065808 7143482 ECED1_1047 Escherichia coli ED1a minor tail protein H YP_002397071.1 1063247 D 585397 CDS YP_002397072.1 218688860 7143483 1065805..1066134 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein M 1066134 7143483 ECED1_1048 Escherichia coli ED1a minor tail protein M YP_002397072.1 1065805 D 585397 CDS YP_002397073.1 218688861 7143484 complement(1066032..1066148) 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 1066148 7143484 ECED1_1049 Escherichia coli ED1a hypothetical protein YP_002397073.1 1066032 R 585397 CDS YP_002397074.1 218688862 7143485 1066134..1066832 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein L 1066832 7143485 ECED1_1050 Escherichia coli ED1a minor tail protein L YP_002397074.1 1066134 D 585397 CDS YP_002397075.1 218688863 7143486 1066582..1067586 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail fiber component K 1067586 7143486 ECED1_1051 Escherichia coli ED1a tail fiber component K YP_002397075.1 1066582 D 585397 CDS YP_002397076.1 218688864 7143487 1067484..1068164 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail assembly protein I 1068164 7143487 ECED1_1052 Escherichia coli ED1a tail assembly protein I YP_002397076.1 1067484 D 585397 CDS YP_002397077.1 218688865 7143488 1068370..1071945 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Host specificity protein J from prophage 1071945 J 7143488 J Escherichia coli ED1a Host specificity protein J from prophage YP_002397077.1 1068370 D 585397 CDS YP_002397078.1 218688866 7142479 1072130..1073683 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative tail fiber protein from prophage 1073683 7142479 ECED1_1054 Escherichia coli ED1a putative tail fiber protein from prophage YP_002397078.1 1072130 D 585397 CDS YP_002397079.1 218688867 7143489 1073703..1074281 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1074281 7143489 ECED1_1055 Escherichia coli ED1a hypothetical protein YP_002397079.1 1073703 D 585397 CDS YP_002397080.1 218688868 7140631 1075360..1076478 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86192450, 90202716, 92215587; Product type e : enzyme; hydrogenase 1, small subunit 1076478 hyaA 7140631 hyaA Escherichia coli ED1a hydrogenase 1, small subunit YP_002397080.1 1075360 D 585397 CDS YP_002397081.1 218688869 7140180 1076475..1078268 1 NC_011745.1 involved in hydrogen cycling during fermentative growth; hydrogenase 1 large subunit 1078268 hyaB 7140180 hyaB Escherichia coli ED1a hydrogenase 1 large subunit YP_002397081.1 1076475 D 585397 CDS YP_002397082.1 218688870 7140181 1078287..1078994 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90202716, 91310595, 92215587; Product type c : carrier; hydrogenase 1 b-type cytochrome subunit 1078994 hyaC 7140181 hyaC Escherichia coli ED1a hydrogenase 1 b-type cytochrome subunit YP_002397082.1 1078287 D 585397 CDS YP_002397083.1 218688871 7140182 1078991..1079578 1 NC_011745.1 HyaD; endopeptidase involved in the cleavage of the C-terminus end of HyaB (the large subunit of hydrogenase 1); hydrogenase 1 maturation protease 1079578 hyaD 7140182 hyaD Escherichia coli ED1a hydrogenase 1 maturation protease YP_002397083.1 1078991 D 585397 CDS YP_002397084.1 218688872 7140183 1079575..1079973 1 NC_011745.1 involved in processing hydrogenase proteins HyaA and HyaB; hydrogenase-1 operon protein HyaE 1079973 hyaE 7140183 hyaE Escherichia coli ED1a hydrogenase-1 operon protein HyaE YP_002397084.1 1079575 D 585397 CDS YP_002397085.1 218688873 7140184 1079970..1080827 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90202716, 91310595, 92215587; Product type f : factor; protein involved in nickel incorporation into hydrogenase-1 proteins 1080827 hyaF 7140184 hyaF Escherichia coli ED1a protein involved in nickel incorporation into hydrogenase-1 proteins YP_002397085.1 1079970 D 585397 CDS YP_002397086.1 218688874 7140185 1080961..1082505 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92049231, 96198179; Product type c : carrier; cytochrome bd-II oxidase subunit I 1082505 appC 7140185 appC Escherichia coli ED1a cytochrome bd-II oxidase subunit I YP_002397086.1 1080961 D 585397 CDS YP_002397087.1 218688875 7142593 1082517..1083653 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92049231, 96198179; Product type c : carrier; cytochrome bd-II oxidase subunit II 1083653 appB 7142593 appB Escherichia coli ED1a cytochrome bd-II oxidase subunit II YP_002397087.1 1082517 D 585397 CDS YP_002397088.1 218688876 7142592 1083850..1085148 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20122624, 92049231, 93054596, 10696472, 2168385, 3038201, 8387749; Product type e : enzyme; phosphoanhydride phosphorylase 1085148 appA 7142592 appA Escherichia coli ED1a phosphoanhydride phosphorylase YP_002397088.1 1083850 D 585397 CDS YP_002397089.1 218688877 7142591 complement(1085136..1085348) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9484881, 9439003; Product type f : factor; stress protein, member of the CspA-family 1085348 cspH 7142591 cspH Escherichia coli ED1a stress protein, member of the CspA-family YP_002397089.1 1085136 R 585397 CDS YP_002397090.1 218688878 7142074 1085632..1085844 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9484881, 15466053, 8631696, 9439003; Product type r : regulator; cold shock protein CspG 1085844 cspG 7142074 cspG Escherichia coli ED1a cold shock protein CspG YP_002397090.1 1085632 D 585397 CDS YP_002397091.1 218688879 7142073 1086238..1086411 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15317805, 11544213; Product type pr : putative regulator; putative regulator of phosphatidylethanolamine synthesis 1086411 gnsA 7142073 gnsA Escherichia coli ED1a putative regulator of phosphatidylethanolamine synthesis YP_002397091.1 1086238 D 585397 CDS YP_002397092.1 218688880 7142999 complement(1086460..1087533) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative 4Fe-4S membrane protein 1087533 yccM 7142999 yccM Escherichia coli ED1a putative 4Fe-4S membrane protein YP_002397092.1 1086460 R 585397 CDS YP_002397093.1 218688881 7142722 complement(1087616..1090348) 1 NC_011745.1 Member of the two-component regulatory system torS/torR involved in the anaerobic utilization of trimethylamine-N-oxide; hybrid sensory histidine kinase TorS 1090348 torS 7142722 torS Escherichia coli ED1a hybrid sensory histidine kinase TorS YP_002397093.1 1087616 R 585397 CDS YP_002397094.1 218688882 7140796 1090431..1091459 1 NC_011745.1 periplasmic sensory protein associated with the TorRS two-component regulatory system; TMAO reductase system periplasmic protein TorT 1091459 torT 7140796 torT Escherichia coli ED1a TMAO reductase system periplasmic protein TorT YP_002397094.1 1090431 D 585397 CDS YP_002397095.1 218688883 7140797 complement(1091432..1092124) 1 NC_011745.1 response regulator in two-component regulatory system with TorS; involved in regulation of trimethylamine N-oxide reductase genes; DNA-binding transcriptional regulator TorR 1092124 torR 7140797 torR Escherichia coli ED1a DNA-binding transcriptional regulator TorR YP_002397095.1 1091432 R 585397 CDS YP_002397096.1 218688884 7140795 1092254..1093426 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94293785, 94314186, 99340208, 11056172, 11562502; Product type c : carrier; trimethylamine N-oxide (TMAO) reductase I, cytochrome c-type subunit 1093426 torC 7140795 torC Escherichia coli ED1a trimethylamine N-oxide (TMAO) reductase I, cytochrome c-type subunit YP_002397096.1 1092254 D 585397 CDS YP_002397097.1 218688885 7140793 1093426..1095972 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88193091, 90089471, 94293785, 8302830, 8022286; Product type e : enzyme; trimethylamine N-oxide (TMAO) reductase I, catalytic subunit 1095972 torA 7140793 torA Escherichia coli ED1a trimethylamine N-oxide (TMAO) reductase I, catalytic subunit YP_002397097.1 1093426 D 585397 CDS YP_002397098.1 218688886 7140792 1095969..1096568 1 NC_011745.1 TorD; involved in the biogenesis of torA; acts on torA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor; chaperone protein TorD 1096568 torD 7140792 torD Escherichia coli ED1a chaperone protein TorD YP_002397098.1 1095969 D 585397 CDS YP_002397099.1 218688887 7140794 complement(1096925..1097230) 1 NC_011745.1 with CpbA modulates the activity of the dnaK chaperone system; interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA; chaperone-modulator protein CbpM 1097230 cbpM 7140794 cbpM Escherichia coli ED1a chaperone-modulator protein CbpM YP_002397099.1 1096925 R 585397 CDS YP_002397100.1 218688888 7139310 complement(1097230..1098150) 1 NC_011745.1 functional analog of DnaJ; co-chaperone with DnaK, molecular chaperone in an adaptive response to environmental stresses other than heat shock; curved DNA-binding protein CbpA 1098150 cbpA 7139310 cbpA Escherichia coli ED1a curved DNA-binding protein CbpA YP_002397100.1 1097230 R 585397 CDS YP_002397101.1 218688889 7143679 1099143..1099418 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 1099418 insA 7143679 insA Escherichia coli ED1a IS1 repressor protein InsA YP_002397101.1 1099143 D 585397 CDS YP_002397102.1 218688890 7141116 1099337..1099840 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 1099840 insB 7141116 insB Escherichia coli ED1a IS1 transposase InsAB' YP_002397102.1 1099337 D 585397 CDS YP_002397103.1 218688891 7143680 complement(1100740..1100967) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1100967 yccJ 7143680 yccJ Escherichia coli ED1a hypothetical protein YP_002397103.1 1100740 R 585397 CDS YP_002397104.1 218688892 7142721 complement(1100988..1101566) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16322580, 93296226, 9694845; Product type pr : putative regulator; putative flavoprotein 1101566 wrbA 7142721 wrbA Escherichia coli ED1a putative flavoprotein YP_002397104.1 1100988 R 585397 CDS YP_002397105.1 218688893 7139189 complement(1101563..1102897) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; phage integrase 1102897 int 7139189 int Escherichia coli ED1a phage integrase YP_002397105.1 1101563 R 585397 CDS YP_002397106.1 218688894 7141173 complement(1102926..1103210) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative excisionase 1103210 7141173 ECED1_1085 Escherichia coli ED1a putative excisionase YP_002397106.1 1102926 R 585397 CDS YP_002397107.1 218688895 7143491 complement(1103256..1103516) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1103516 7143491 ECED1_1086 Escherichia coli ED1a hypothetical protein YP_002397107.1 1103256 R 585397 CDS YP_002397108.1 218688896 7143492 complement(1103555..1104235) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; exonuclease from phage origin 1104235 7143492 ECED1_1087 Escherichia coli ED1a exonuclease from phage origin YP_002397108.1 1103555 R 585397 CDS YP_002397109.1 218688897 7143493 complement(1104232..1105017) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 6458018, 6221115; Product type h : extrachromosomal origin; Recombination protein bet from phage origin 1105017 7143493 ECED1_1088 Escherichia coli ED1a Recombination protein bet from phage origin YP_002397109.1 1104232 R 585397 CDS YP_002397110.1 218688898 7143494 complement(1105023..1105319) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative host-nuclease inhibitor protein Gam of bacteriophage 1105319 7143494 ECED1_1089 Escherichia coli ED1a putative host-nuclease inhibitor protein Gam of bacteriophage YP_002397110.1 1105023 R 585397 CDS YP_002397111.1 218688899 7143495 complement(1105316..1107388) 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2199308; Product type h : extrachromosomal origin; Exodeoxyribonuclease VIII (putative partial) from phage origin 1107388 7143495 ECED1_1090 Escherichia coli ED1a Exodeoxyribonuclease VIII (putative partial) from phage origin YP_002397111.1 1105316 R 585397 CDS YP_002397112.1 218688900 7143496 complement(1107496..1107882) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1107882 7143496 ECED1_1091 Escherichia coli ED1a hypothetical protein YP_002397112.1 1107496 R 585397 CDS YP_002397113.1 218688901 7143497 complement(1107966..1108187) 1 NC_011745.1 Rac prophage Kil protein; Kil overexpression leads to morphological defects and inhibits cell division; FtsZ inhibitor protein 1108187 kil 7143497 kil Escherichia coli ED1a FtsZ inhibitor protein YP_002397113.1 1107966 R 585397 CDS YP_002397114.1 218688902 7142512 1108644..1108853 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1108853 7142512 ECED1_1093 Escherichia coli ED1a hypothetical protein YP_002397114.1 1108644 D 585397 CDS YP_002397115.1 218688903 7143498 complement(1108822..1109202) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1109202 7143498 ECED1_1094 Escherichia coli ED1a hypothetical protein YP_002397115.1 1108822 R 585397 CDS YP_002397116.1 218688904 7143499 complement(1109213..1109929) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1109929 7143499 ECED1_1095 Escherichia coli ED1a hypothetical protein YP_002397116.1 1109213 R 585397 CDS YP_002397117.1 218688905 7143500 complement(1109930..1110313) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Antitermination protein N 1110313 N 7143500 N Escherichia coli ED1a Antitermination protein N YP_002397117.1 1109930 R 585397 CDS YP_002397118.1 218688906 7140327 complement(1110811..1111587) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1111587 7140327 ECED1_1097 Escherichia coli ED1a hypothetical protein YP_002397118.1 1110811 R 585397 CDS YP_002397119.1 218688907 7143501 complement(1111575..1112117) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1112117 7143501 ECED1_1098 Escherichia coli ED1a hypothetical protein YP_002397119.1 1111575 R 585397 CDS YP_002397120.1 218688908 7143502 complement(1112164..1112877) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Repressor protein CI from prophage 1112877 CI 7143502 CI Escherichia coli ED1a Repressor protein CI from prophage YP_002397120.1 1112164 R 585397 CDS YP_002397121.1 218688909 7139353 1112978..1113178 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; regulatory protein cro 1113178 cro 7139353 cro Escherichia coli ED1a regulatory protein cro YP_002397121.1 1112978 D 585397 CDS YP_002397122.1 218688910 7142055 1113317..1113613 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; regulatory protein CII from prophage 1113613 cII 7142055 cII Escherichia coli ED1a regulatory protein CII from prophage YP_002397122.1 1113317 D 585397 CDS YP_002397123.1 218688911 7139356 1113628..1113846 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1113846 7139356 ECED1_1102 Escherichia coli ED1a hypothetical protein YP_002397123.1 1113628 D 585397 CDS YP_002397124.1 218688912 7143503 1113867..1114955 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1114955 7143503 ECED1_1103 Escherichia coli ED1a hypothetical protein YP_002397124.1 1113867 D 585397 CDS YP_002397125.1 218688913 7143504 1114962..1115702 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative replication protein 1115702 ydaV 7143504 ydaV Escherichia coli ED1a putative replication protein YP_002397125.1 1114962 D 585397 CDS YP_002397126.1 218688914 7142016 1115728..1116498 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1116498 7142016 ECED1_1105 Escherichia coli ED1a hypothetical protein YP_002397126.1 1115728 D 585397 CDS YP_002397127.1 218688915 7143505 1116508..1116945 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1116945 7143505 ECED1_1106 Escherichia coli ED1a hypothetical protein YP_002397127.1 1116508 D 585397 CDS YP_002397128.1 218688916 7143506 complement(1116978..1117652) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1117652 7143506 ECED1_1107 Escherichia coli ED1a hypothetical protein YP_002397128.1 1116978 R 585397 CDS YP_002397129.1 218688917 7143507 1117546..1117896 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1117896 7143507 ECED1_1108 Escherichia coli ED1a hypothetical protein YP_002397129.1 1117546 D 585397 CDS YP_002397130.1 218688918 7143508 complement(1117951..1118259) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative transcriptional regulator from the CI family 1118259 7143508 ECED1_1109 Escherichia coli ED1a putative transcriptional regulator from the CI family YP_002397130.1 1117951 R 585397 CDS YP_002397131.1 218688919 7143509 complement(1118249..1118716) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1118716 7143509 ECED1_1110 Escherichia coli ED1a hypothetical protein YP_002397131.1 1118249 R 585397 CDS YP_002397132.1 218688920 7143510 1118898..1119569 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative antirepressor protein Ant from prophage 1119569 7143510 ECED1_1111 Escherichia coli ED1a putative antirepressor protein Ant from prophage YP_002397132.1 1118898 D 585397 CDS YP_002397133.1 218688921 7143511 1119624..1120034 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative ninB protein 1120034 7143511 ECED1_1112 Escherichia coli ED1a putative ninB protein YP_002397133.1 1119624 D 585397 CDS YP_002397134.1 218688922 7143512 1120298..1120489 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 1120489 7143512 ECED1_1113 Escherichia coli ED1a hypothetical protein YP_002397134.1 1120298 D 585397 CDS YP_002397135.1 218688923 7143513 1120533..1120895 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; crossover junction endodeoxyribonuclease 1120895 rusA 7143513 rusA Escherichia coli ED1a crossover junction endodeoxyribonuclease YP_002397135.1 1120533 D 585397 CDS YP_002397136.1 218688924 7140137 1120892..1121092 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Protein ninH from prophage 1121092 ninH 7140137 ninH Escherichia coli ED1a Protein ninH from prophage YP_002397136.1 1120892 D 585397 CDS YP_002397137.1 218688925 7140393 1120980..1121327 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1121327 7140393 ECED1_1116 Escherichia coli ED1a hypothetical protein YP_002397137.1 1120980 D 585397 CDS YP_002397138.1 218688926 7143514 1121315..1121941 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1121941 7143514 ECED1_1117 Escherichia coli ED1a hypothetical protein YP_002397138.1 1121315 D 585397 CDS YP_002397139.1 218688927 7143515 complement(1122217..1122456) 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 1122456 7143515 ECED1_1118 Escherichia coli ED1a hypothetical protein YP_002397139.1 1122217 R 585397 CDS YP_002397140.1 218688928 7143516 1122679..1122846 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 1122846 7143516 ECED1_1119 Escherichia coli ED1a hypothetical protein YP_002397140.1 1122679 D 585397 CDS YP_002397141.1 218688929 7143517 1122910..1123068 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 1123068 7143517 ECED1_1120 Escherichia coli ED1a hypothetical protein YP_002397141.1 1122910 D 585397 CDS YP_002397142.1 218688930 7143518 1123361..1125364 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; hypothetical protein 1125364 7143518 ECED1_1121 Escherichia coli ED1a hypothetical protein YP_002397142.1 1123361 D 585397 CDS YP_002397143.1 218688931 7143519 1125552..1126016 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1126016 7143519 ECED1_1122 Escherichia coli ED1a hypothetical protein YP_002397143.1 1125552 D 585397 CDS YP_002397144.1 218688932 7143520 1126093..1126308 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2019562; Product type h : extrachromosomal origin; Lysis protein S from bacteriophage origin 1126308 S 7143520 S Escherichia coli ED1a Lysis protein S from bacteriophage origin YP_002397144.1 1126093 D 585397 CDS YP_002397145.1 218688933 7141362 1126313..1126846 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-associated lysozyme; Qin prophage 1126846 ydfQ 7141362 ydfQ Escherichia coli ED1a putative membrane-associated lysozyme; Qin prophage YP_002397145.1 1126313 D 585397 CDS YP_002397146.1 218688934 7139264 1126970..1127185 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1127185 7139264 ECED1_1125 Escherichia coli ED1a hypothetical protein YP_002397146.1 1126970 D 585397 CDS YP_002397147.1 218688935 7143521 1127110..1127331 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1127331 7143521 ECED1_1126 Escherichia coli ED1a hypothetical protein YP_002397147.1 1127110 D 585397 CDS YP_002397148.1 218688936 7143522 1127339..1127806 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Endopeptidase (Lysis protein) from bacteriophage origin 1127806 rz 7143522 rz Escherichia coli ED1a Endopeptidase (Lysis protein) from bacteriophage origin YP_002397148.1 1127339 D 585397 CDS YP_002397149.1 218688937 7141357 1127983..1128534 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage protein Rha 1128534 7141357 ECED1_1128 Escherichia coli ED1a putative phage protein Rha YP_002397149.1 1127983 D 585397 CDS YP_002397150.1 218688938 7143523 1128834..1129616 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative small subunit terminase from prophage 1129616 7143523 ECED1_1129 Escherichia coli ED1a putative small subunit terminase from prophage YP_002397150.1 1128834 D 585397 CDS YP_002397151.1 218688939 7143524 1129597..1131303 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative large subunit terminase 1131303 7143524 ECED1_1130 Escherichia coli ED1a putative large subunit terminase YP_002397151.1 1129597 D 585397 CDS YP_002397152.1 218688940 7143525 1131303..1133447 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative portal protein 1133447 7143525 ECED1_1131 Escherichia coli ED1a putative portal protein YP_002397152.1 1131303 D 585397 CDS YP_002397153.1 218688941 7143526 1133605..1134612 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1134612 7143526 ECED1_1132 Escherichia coli ED1a hypothetical protein YP_002397153.1 1133605 D 585397 CDS YP_002397154.1 218688942 7143527 1134635..1135849 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1135849 7143527 ECED1_1133 Escherichia coli ED1a hypothetical protein YP_002397154.1 1134635 D 585397 CDS YP_002397155.1 218688943 7143528 1135904..1136296 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1136296 7143528 ECED1_1134 Escherichia coli ED1a hypothetical protein YP_002397155.1 1135904 D 585397 CDS YP_002397156.1 218688944 7143529 1136347..1136808 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1136808 7143529 ECED1_1135 Escherichia coli ED1a hypothetical protein YP_002397156.1 1136347 D 585397 CDS YP_002397157.1 218688945 7143530 1136732..1137355 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1137355 7143530 ECED1_1136 Escherichia coli ED1a hypothetical protein YP_002397157.1 1136732 D 585397 CDS YP_002397158.1 218688946 7143531 1137355..1138005 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1138005 7143531 ECED1_1137 Escherichia coli ED1a hypothetical protein YP_002397158.1 1137355 D 585397 CDS YP_002397159.1 218688947 7143532 1138002..1139702 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1139702 7143532 ECED1_1138 Escherichia coli ED1a hypothetical protein YP_002397159.1 1138002 D 585397 CDS YP_002397160.1 218688948 7143533 1139722..1140300 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1140300 7143533 ECED1_1139 Escherichia coli ED1a hypothetical protein YP_002397160.1 1139722 D 585397 CDS YP_002397161.1 218688949 7143534 complement(1140488..1140637) 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 1140637 7143534 ECED1_1140 Escherichia coli ED1a hypothetical protein YP_002397161.1 1140488 R 585397 CDS YP_002397162.1 218688950 7143535 1141109..1142188 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative immunoglobulin-binding protein from phage origin 1142188 7143535 ECED1_1141 Escherichia coli ED1a putative immunoglobulin-binding protein from phage origin YP_002397162.1 1141109 D 585397 CDS YP_002397163.1 218688951 7143536 1142247..1142747 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1142747 7143536 ECED1_1142 Escherichia coli ED1a hypothetical protein YP_002397163.1 1142247 D 585397 CDS YP_002397164.1 218688952 7143537 1142747..1142929 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1142929 7143537 ECED1_1143 Escherichia coli ED1a hypothetical protein YP_002397164.1 1142747 D 585397 CDS YP_002397165.1 218688953 7143538 1143032..1144735 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1144735 7143538 ECED1_1144 Escherichia coli ED1a hypothetical protein YP_002397165.1 1143032 D 585397 CDS YP_002397166.1 218688954 7143539 1144732..1146000 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1146000 7143539 ECED1_1145 Escherichia coli ED1a hypothetical protein YP_002397166.1 1144732 D 585397 CDS YP_002397167.1 218688955 7143540 1146015..1146296 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1146296 7143540 ECED1_1146 Escherichia coli ED1a hypothetical protein YP_002397167.1 1146015 D 585397 CDS YP_002397168.1 218688956 7143541 1146293..1146919 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1146919 7143541 ECED1_1147 Escherichia coli ED1a hypothetical protein YP_002397168.1 1146293 D 585397 CDS YP_002397169.1 218688957 7143542 1147006..1147737 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; outer membrane protein Lom 1147737 lom 7143542 lom Escherichia coli ED1a outer membrane protein Lom YP_002397169.1 1147006 D 585397 CDS YP_002397170.1 218688958 7141905 1148165..1148566 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1148566 7141905 ECED1_1149 Escherichia coli ED1a hypothetical protein YP_002397170.1 1148165 D 585397 CDS YP_002397171.1 218688959 7143543 1148660..1149316 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1149316 7143543 ECED1_1150 Escherichia coli ED1a hypothetical protein YP_002397171.1 1148660 D 585397 CDS YP_002397172.1 218688960 7143544 1149319..1149765 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1149765 7143544 ECED1_1151 Escherichia coli ED1a hypothetical protein YP_002397172.1 1149319 D 585397 CDS YP_002397173.1 218688961 7143545 1149775..1150026 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1150026 7143545 ECED1_1152 Escherichia coli ED1a hypothetical protein YP_002397173.1 1149775 D 585397 CDS YP_002397174.1 218688962 7143546 1150037..1151302 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1151302 7143546 ECED1_1153 Escherichia coli ED1a hypothetical protein YP_002397174.1 1150037 D 585397 CDS YP_002397175.1 218688963 7143547 1151371..1159734 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1159734 7143547 ECED1_1154 Escherichia coli ED1a hypothetical protein YP_002397175.1 1151371 D 585397 CDS YP_002397176.1 218688964 7143548 1159885..1160409 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1160409 7143548 ECED1_1155 Escherichia coli ED1a hypothetical protein YP_002397176.1 1159885 D 585397 CDS YP_002397177.1 218688965 7142526 complement(1160498..1161142) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; transcriptional regulator IbrB 1161142 ibrB 7142526 ibrB Escherichia coli ED1a transcriptional regulator IbrB YP_002397177.1 1160498 R 585397 CDS YP_002397178.1 218688966 7140220 complement(1161127..1162353) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12057959; Product type r : regulator; immunoglobulin-binding regulator 1162353 ibrA 7140220 ibrA Escherichia coli ED1a immunoglobulin-binding regulator YP_002397178.1 1161127 R 585397 CDS YP_002397179.1 218688967 7140218 complement(1162550..1163341) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; phage anti-repressor protein 1163341 antB 7140218 antB Escherichia coli ED1a phage anti-repressor protein YP_002397179.1 1162550 R 585397 CDS YP_002397180.1 218688968 7142587 complement(1163460..1163897) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1163897 7142587 ECED1_1159 Escherichia coli ED1a hypothetical protein YP_002397180.1 1163460 R 585397 CDS YP_002397181.1 218688969 7142527 1164544..1164780 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 1164780 7142527 ECED1_1160 Escherichia coli ED1a hypothetical protein YP_002397181.1 1164544 D 585397 CDS YP_002397182.1 218688970 7142528 1164713..1164886 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1164886 ymdF 7142528 ymdF Escherichia coli ED1a hypothetical protein YP_002397182.1 1164713 D 585397 CDS YP_002397183.1 218688971 7140976 complement(1164969..1166297) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type t : transporter; pyrimidine transporter 1166297 rutG 7140976 rutG Escherichia coli ED1a pyrimidine transporter YP_002397183.1 1164969 R 585397 CDS YP_002397184.1 218688972 7140144 complement(1166318..1166812) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542, 10633095; Product type e : enzyme; alternative pyrimidine degradation pathway flavin:NADH oxidoreductase subunit 1166812 rutF 7140144 rutF Escherichia coli ED1a alternative pyrimidine degradation pathway flavin:NADH oxidoreductase subunit YP_002397184.1 1166318 R 585397 CDS YP_002397185.1 218688973 7140143 complement(1166823..1167413) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme; hypothetical protein 1167413 rutE 7140143 rutE Escherichia coli ED1a hypothetical protein YP_002397185.1 1166823 R 585397 CDS YP_002397186.1 218688974 7140142 complement(1167423..1168223) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme; enzyme of the alternative pyrimidine degradation pathway 1168223 rutD 7140142 rutD Escherichia coli ED1a enzyme of the alternative pyrimidine degradation pathway YP_002397186.1 1167423 R 585397 CDS YP_002397187.1 218688975 7140141 complement(1168231..1168617) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme; enzyme of the alternative pyrimidine degradation pathway 1168617 rutC 7140141 rutC Escherichia coli ED1a enzyme of the alternative pyrimidine degradation pathway YP_002397187.1 1168231 R 585397 CDS YP_002397188.1 218688976 7140140 complement(1168629..1169321) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme; enzyme of the alternative pyrimidine degradation pathway 1169321 rutB 7140140 rutB Escherichia coli ED1a enzyme of the alternative pyrimidine degradation pathway YP_002397188.1 1168629 R 585397 CDS YP_002397189.1 218688977 7140139 complement(1169321..1170469) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme; alternative pyrimidine degradation pathway monooxygenase 1170469 rutA 7140139 rutA Escherichia coli ED1a alternative pyrimidine degradation pathway monooxygenase YP_002397189.1 1169321 R 585397 CDS YP_002397190.1 218688978 7140138 1170693..1171331 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type r : regulator; alternative pyrimidine degradation pathway DNA-binding transcriptional regulator 1171331 rutR 7140138 rutR Escherichia coli ED1a alternative pyrimidine degradation pathway DNA-binding transcriptional regulator YP_002397190.1 1170693 D 585397 CDS YP_002397191.1 218688979 7140145 complement(1171371..1175333) 1 NC_011745.1 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichai coli this protein also self-regulates transcription via a DNA-binding domain at the N-terminus; forms dimers and is a peripherally membrane-associated protein; trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 1175333 putA 7140145 putA Escherichia coli ED1a trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase YP_002397191.1 1171371 R 585397 CDS YP_002397192.1 218688980 7141227 1175756..1177264 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12923181, 88213396, 91227628, 93132799, 98359785, 1400239, 1567896, 3053649, 3053687, 3302614, 3325781, 8119910; Product type t : transporter; proline:sodium symporter 1177264 putP 7141227 putP Escherichia coli ED1a proline:sodium symporter YP_002397192.1 1175756 D 585397 CDS YP_002397193.1 218688981 7141228 1177475..1178314 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type t : transporter; ferrous iron permease 1178314 efeU 7141228 efeU Escherichia coli ED1a ferrous iron permease YP_002397193.1 1177475 D 585397 CDS YP_002397194.1 218688982 7139776 1178372..1179499 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 17627767, 10493123; Product type t : transporter; hypothetical protein 1179499 efeO 7139776 efeO Escherichia coli ED1a hypothetical protein YP_002397194.1 1178372 D 585397 CDS YP_002397195.1 218688983 7139775 1179505..1180776 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 17627767, 16551627, 15375152; Product type t : transporter; iron transport heme-binding periplasmic protein 1180776 efeB 7139775 efeB Escherichia coli ED1a iron transport heme-binding periplasmic protein YP_002397195.1 1179505 D 585397 CDS YP_002397196.1 218688984 7139774 1181127..1182191 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8444794, 2160940; Product type pe : putative enzyme; hypothetical protein 1182191 phoH 7139774 phoH Escherichia coli ED1a hypothetical protein YP_002397196.1 1181127 D 585397 CDS YP_002397197.1 218688985 7144105 1182780..1183466 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1183466 7144105 ECED1_1176 Escherichia coli ED1a hypothetical protein YP_002397197.1 1182780 D 585397 CDS YP_002397198.1 218688986 7140630 1183879..1184817 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11237876, 10493123; Product type e : enzyme; 2-ketoacid reductase 1184817 ycdW 7140630 ycdW Escherichia coli ED1a 2-ketoacid reductase YP_002397198.1 1183879 D 585397 CDS YP_002397199.1 218688987 7142730 1184872..1185609 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12661000; Product type pe : putative enzyme; putative hydrolase 1185609 ycdX 7142730 ycdX Escherichia coli ED1a putative hydrolase YP_002397199.1 1184872 D 585397 CDS YP_002397200.1 218688988 7142731 1185633..1186187 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1186187 ycdY 7142731 ycdY Escherichia coli ED1a hypothetical protein YP_002397200.1 1185633 D 585397 CDS YP_002397201.1 218688989 7142732 1186289..1186780 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1186780 ycdZ 7142732 ycdZ Escherichia coli ED1a hypothetical protein YP_002397201.1 1186289 D 585397 CDS YP_002397202.1 218688990 7142733 complement(1186844..1187677) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8817489; Product type lp : lipoprotein; putative outer membrane lipoprotein involved in curli production assembly/transport 1187677 csgG 7142733 csgG Escherichia coli ED1a putative outer membrane lipoprotein involved in curli production assembly/transport YP_002397202.1 1186844 R 585397 CDS YP_002397203.1 218688991 7142066 complement(1187704..1188120) 1 NC_011745.1 nucleator protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgF 1188120 csgF 7142066 csgF Escherichia coli ED1a curli assembly protein CsgF YP_002397203.1 1187704 R 585397 CDS YP_002397204.1 218688992 7142065 complement(1188145..1188534) 1 NC_011745.1 chaperone-like protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgE 1188534 csgE 7142065 csgE Escherichia coli ED1a curli assembly protein CsgE YP_002397204.1 1188145 R 585397 CDS YP_002397205.1 218688993 7142064 complement(1188539..1189189) 1 NC_011745.1 activates the csgBA and csgDEFG operons involved in biofilm formation; DNA-binding transcriptional regulator CsgD 1189189 csgD 7142064 csgD Escherichia coli ED1a DNA-binding transcriptional regulator CsgD YP_002397205.1 1188539 R 585397 CDS YP_002397206.1 218688994 7142063 1189932..1190387 1 NC_011745.1 CsgB; functions as a nucleator in the assembly of curli (coiled surface structures) on the cell surface; curlin minor subunit 1190387 csgB 7142063 csgB Escherichia coli ED1a curlin minor subunit YP_002397206.1 1189932 D 585397 CDS YP_002397207.1 218688995 7142061 1190428..1190886 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89201357, 93023873, 1677357, 8459772, 8817489, 1357528; Product type s : structure; cryptic curlin major subunit 1190886 csgA 7142061 csgA Escherichia coli ED1a cryptic curlin major subunit YP_002397207.1 1190428 D 585397 CDS YP_002397208.1 218688996 7142060 1190945..1191277 1 NC_011745.1 involved in autoagglutination of curliated cells; not involved in production of curli fibers; putative autoagglutination protein 1191277 csgC 7142060 csgC Escherichia coli ED1a putative autoagglutination protein YP_002397208.1 1190945 D 585397 CDS YP_002397209.1 218688997 7142062 1191398..1191709 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1191709 ymdA 7142062 ymdA Escherichia coli ED1a hypothetical protein YP_002397209.1 1191398 D 585397 CDS YP_002397210.1 218688998 7140973 1191804..1192337 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1192337 ymdB 7140973 ymdB Escherichia coli ED1a hypothetical protein YP_002397210.1 1191804 D 585397 CDS YP_002397211.1 218688999 7140974 1192339..1193760 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase 1193760 ymdC 7140974 ymdC Escherichia coli ED1a putative hydrolase YP_002397211.1 1192339 D 585397 CDS YP_002397212.1 218689000 7140975 complement(1193768..1194925) 1 NC_011745.1 required for the transfer of succinyl residues to the glucan backbone; glucans biosynthesis protein 1194925 mdoC 7140975 mdoC Escherichia coli ED1a glucans biosynthesis protein YP_002397212.1 1193768 R 585397 CDS YP_002397213.1 218689001 7142223 complement(1194970..1195113) 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 1195113 7142223 ECED1_1192 Escherichia coli ED1a hypothetical protein YP_002397213.1 1194970 R 585397 CDS YP_002397214.1 218689002 7142530 complement(1195117..1195275) 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 1195275 7142530 ECED1_1193 Escherichia coli ED1a hypothetical protein YP_002397214.1 1195117 R 585397 CDS YP_002397215.1 218689003 7142531 1195319..1196854 1 NC_011745.1 involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan; glucan biosynthesis protein G 1196854 mdoG 7142531 mdoG Escherichia coli ED1a glucan biosynthesis protein G YP_002397215.1 1195319 D 585397 CDS YP_002397216.1 218689004 7142225 1196847..1199390 1 NC_011745.1 necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space; glucosyltransferase MdoH 1199390 mdoH 7142225 mdoH Escherichia coli ED1a glucosyltransferase MdoH YP_002397216.1 1196847 D 585397 CDS YP_002397217.1 218689005 7142226 1199562..1199789 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein 1199789 yceK 7142226 yceK Escherichia coli ED1a hypothetical protein YP_002397217.1 1199562 D 585397 CDS YP_002397218.1 218689006 7143480 complement(1199790..1200164) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 92165719; hypothetical protein 1200164 msyB 7143480 msyB Escherichia coli ED1a hypothetical protein YP_002397218.1 1199790 R 585397 CDS YP_002397219.1 218689007 7139036 complement(1200247..1201473) 1 NC_011745.1 Confers resistance to fosfomycin and deoxycholate; drug efflux system protein MdtG 1201473 mdtG 7139036 mdtG Escherichia coli ED1a drug efflux system protein MdtG YP_002397219.1 1200247 R 585397 CDS YP_002397220.1 218689008 7142233 complement(1201645..1202565) 1 NC_011745.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase 1202565 lpxL 7142233 lpxL Escherichia coli ED1a lipid A biosynthesis lauroyl acyltransferase YP_002397220.1 1201645 R 585397 CDS YP_002397221.1 218689009 7141923 1202790..1203842 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1840644; hypothetical protein 1203842 yceA 7141923 yceA Escherichia coli ED1a hypothetical protein YP_002397221.1 1202790 D 585397 CDS YP_002397222.1 218689010 7142734 complement(1203884..1204459) 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15741337, 11298273, 1840644, 9298646; Product type c : carrier; hypothetical protein 1204459 yceI 7142734 yceI Escherichia coli ED1a hypothetical protein YP_002397222.1 1203884 R 585397 CDS YP_002397223.1 218689011 7142740 complement(1204463..1205029) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative cytochrome b561 1205029 yceJ 7142740 yceJ Escherichia coli ED1a putative cytochrome b561 YP_002397223.1 1204463 R 585397 CDS YP_002397224.1 218689012 7142741 complement(1205451..1206569) 1 NC_011745.1 catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids; N-methyltryptophan oxidase 1206569 solA 7142741 solA Escherichia coli ED1a N-methyltryptophan oxidase YP_002397224.1 1205451 R 585397 CDS YP_002397225.1 218689013 7143820 complement(1206684..1206938) 1 NC_011745.1 BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing; biofilm formation regulatory protein BssS 1206938 bssS 7143820 bssS Escherichia coli ED1a biofilm formation regulatory protein BssS YP_002397225.1 1206684 R 585397 CDS YP_002397226.1 218689014 7140464 complement(1207228..1207473) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9606202, 11152126, 11230150, 8682790; Product type f : factor; DNA damage-inducible protein I 1207473 dinI 7140464 dinI Escherichia coli ED1a DNA damage-inducible protein I YP_002397226.1 1207228 R 585397 CDS YP_002397227.1 218689015 7140491 complement(1207547..1208593) 1 NC_011745.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 1208593 pyrC 7140491 pyrC Escherichia coli ED1a dihydroorotase YP_002397227.1 1207547 R 585397 CDS YP_002397228.1 218689016 7141232 complement(1208699..1209259) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein 1209259 yceB 7141232 yceB Escherichia coli ED1a hypothetical protein YP_002397228.1 1208699 R 585397 CDS YP_002397229.1 218689017 7142735 complement(1209393..1210040) 1 NC_011745.1 cofactor involved in the reduction of disulfides; glutaredoxin 2 1210040 grxB 7142735 grxB Escherichia coli ED1a glutaredoxin 2 YP_002397229.1 1209393 R 585397 CDS YP_002397230.1 218689018 7143025 complement(1210104..1211312) 1 NC_011745.1 Confers resistance to norfloxacin and enoxacin; multidrug resistance protein MdtH 1211312 mdtH 7143025 mdtH Escherichia coli ED1a multidrug resistance protein MdtH YP_002397230.1 1210104 R 585397 CDS YP_002397231.1 218689019 7142234 1211548..1212132 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88121676, 90136529, 1356970; Product type e : enzyme; ribosomal-protein-S5-alanine N-acetyltransferase 1212132 rimJ 7142234 rimJ Escherichia coli ED1a ribosomal-protein-S5-alanine N-acetyltransferase YP_002397231.1 1211548 D 585397 CDS YP_002397232.1 218689020 7141417 1212143..1212790 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1356970, 2828880; hypothetical protein 1212790 yceH 7141417 yceH Escherichia coli ED1a hypothetical protein YP_002397232.1 1212143 D 585397 CDS YP_002397233.1 218689021 7142739 1212792..1213715 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase with NAD(P)-binding Rossmann-fold domain 1213715 mviM 7142739 mviM Escherichia coli ED1a putative oxidoreductase with NAD(P)-binding Rossmann-fold domain YP_002397233.1 1212792 D 585397 CDS YP_002397234.1 218689022 7140324 1213825..1215360 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1215360 mviN 7140324 mviN Escherichia coli ED1a hypothetical protein YP_002397234.1 1213825 D 585397 CDS YP_002397235.1 218689023 7140325 complement(1215400..1215816) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10320579; Product type f : factor; export chaperone for FlgK and FlgL 1215816 flgN 7140325 flgN Escherichia coli ED1a export chaperone for FlgK and FlgL YP_002397235.1 1215400 R 585397 CDS YP_002397236.1 218689024 7142123 complement(1215821..1216114) 1 NC_011745.1 regulates the flagellar specific sigma28 transcription factor; anti-sigma28 factor FlgM 1216114 flgM 7142123 flgM Escherichia coli ED1a anti-sigma28 factor FlgM YP_002397236.1 1215821 R 585397 CDS YP_002397237.1 218689025 7142122 complement(1216190..1216849) 1 NC_011745.1 required for the assembly of the flagellar basal body P-ring; flagellar basal body P-ring biosynthesis protein FlgA 1216849 flgA 7142122 flgA Escherichia coli ED1a flagellar basal body P-ring biosynthesis protein FlgA YP_002397237.1 1216190 R 585397 CDS YP_002397238.1 218689026 7144198 1217004..1217420 1 NC_011745.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella; flagellar basal body rod protein FlgB 1217420 flgB 7144198 flgB Escherichia coli ED1a flagellar basal body rod protein FlgB YP_002397238.1 1217004 D 585397 CDS YP_002397239.1 218689027 7142027 1217424..1217828 1 NC_011745.1 with FlgF and B makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgC 1217828 flgC 7142027 flgC Escherichia coli ED1a flagellar basal body rod protein FlgC YP_002397239.1 1217424 D 585397 CDS YP_002397240.1 218689028 7142112 1217840..1218535 1 NC_011745.1 acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production; flagellar basal body rod modification protein 1218535 flgD 7142112 flgD Escherichia coli ED1a flagellar basal body rod modification protein YP_002397240.1 1217840 D 585397 CDS YP_002397241.1 218689029 7142113 1218560..1219765 1 NC_011745.1 the hook connects flagellar basal body to the flagellar filament; flagellar hook protein FlgE 1219765 flgE 7142113 flgE Escherichia coli ED1a flagellar hook protein FlgE YP_002397241.1 1218560 D 585397 CDS YP_002397242.1 218689030 7142114 1219785..1220540 1 NC_011745.1 FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgF 1220540 flgF 7142114 flgF Escherichia coli ED1a flagellar basal body rod protein FlgF YP_002397242.1 1219785 D 585397 CDS YP_002397243.1 218689031 7142115 1220712..1221494 1 NC_011745.1 makes up the distal portion of the flagellar basal body rod; flagellar basal body rod protein FlgG 1221494 flgG 7142115 flgG Escherichia coli ED1a flagellar basal body rod protein FlgG YP_002397243.1 1220712 D 585397 CDS YP_002397244.1 218689032 7142116 1221547..1222245 1 NC_011745.1 part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod; flagellar basal body L-ring protein 1222245 flgH 7142116 flgH Escherichia coli ED1a flagellar basal body L-ring protein YP_002397244.1 1221547 D 585397 CDS YP_002397245.1 218689033 7142117 1222257..1223354 1 NC_011745.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum; flagellar basal body P-ring protein 1223354 flgI 7142117 flgI Escherichia coli ED1a flagellar basal body P-ring protein YP_002397245.1 1222257 D 585397 CDS YP_002397246.1 218689034 7142118 1223354..1224295 1 NC_011745.1 Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space; flagellar rod assembly protein/muramidase FlgJ 1224295 flgJ 7142118 flgJ Escherichia coli ED1a flagellar rod assembly protein/muramidase FlgJ YP_002397246.1 1223354 D 585397 CDS YP_002397247.1 218689035 7142119 1224361..1226004 1 NC_011745.1 with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook; flagellar hook-associated protein FlgK 1226004 flgK 7142119 flgK Escherichia coli ED1a flagellar hook-associated protein FlgK YP_002397247.1 1224361 D 585397 CDS YP_002397248.1 218689036 7142120 1226016..1226969 1 NC_011745.1 with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of this and other flagellar genes; flagellar hook-associated protein FlgL 1226969 flgL 7142120 flgL Escherichia coli ED1a flagellar hook-associated protein FlgL YP_002397248.1 1226016 D 585397 CDS YP_002397249.1 218689037 7142121 complement(1227164..1230349) 1 NC_011745.1 bifunctional ribonuclease E/endoribonuclease/RNA-binding protein/RNA degradosome binding protein; forms part of the membrane-associated degradosome complex along with PNPase, RhlB, and enolase; ribonuclease E 1230349 rne 7142121 rne Escherichia coli ED1a ribonuclease E YP_002397249.1 1227164 R 585397 CDS YP_002397250.1 218689038 7140747 1230922..1231881 1 NC_011745.1 catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA; 23S rRNA pseudouridylate synthase C 1231881 rluC 7140747 rluC Escherichia coli ED1a 23S rRNA pseudouridylate synthase C YP_002397250.1 1230922 D 585397 CDS YP_002397251.1 218689039 7141426 complement(1231993..1232577) 1 NC_011745.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 1232577 yceF 7141426 yceF Escherichia coli ED1a Maf-like protein YP_002397251.1 1231993 R 585397 CDS YP_002397252.1 218689040 7143836 1232776..1233297 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 90008815, 1447160; hypothetical protein 1233297 yceD 7143836 yceD Escherichia coli ED1a hypothetical protein YP_002397252.1 1232776 D 585397 CDS YP_002397253.1 218689041 7142736 1233349..1233522 1 NC_011745.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 1233522 rpmF 7142736 rpmF Escherichia coli ED1a 50S ribosomal protein L32 YP_002397253.1 1233349 D 585397 CDS YP_002397254.1 218689042 7141480 1233603..1234673 1 NC_011745.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; putative glycerol-3-phosphate acyltransferase PlsX 1234673 plsX 7141480 plsX Escherichia coli ED1a putative glycerol-3-phosphate acyltransferase PlsX YP_002397254.1 1233603 D 585397 CDS YP_002397255.1 218689043 7139071 1234741..1235694 1 NC_011745.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-(acyl carrier protein) synthase III 1235694 fabH 7139071 fabH Escherichia coli ED1a 3-oxoacyl-(acyl carrier protein) synthase III YP_002397255.1 1234741 D 585397 CDS YP_002397256.1 218689044 7144120 1235710..1236639 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92052166, 92183950, 92210530, 92234941, 7700236, 7768883, 9298646; Product type e : enzyme; malonyl-CoA-[acyl-carrier-protein] transacylase 1236639 fabD 7144120 fabD Escherichia coli ED1a malonyl-CoA-[acyl-carrier-protein] transacylase YP_002397256.1 1235710 D 585397 CDS YP_002397257.1 218689045 7144035 1236652..1237386 1 NC_011745.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-(acyl-carrier-protein) reductase 1237386 fabG 7144035 fabG Escherichia coli ED1a 3-ketoacyl-(acyl-carrier-protein) reductase YP_002397257.1 1236652 D 585397 CDS YP_002397258.1 218689046 7144119 1237597..1237833 1 NC_011745.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 1237833 acpP 7144119 acpP Escherichia coli ED1a acyl carrier protein YP_002397258.1 1237597 D 585397 CDS YP_002397259.1 218689047 7143646 1237920..1239161 1 NC_011745.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase II 1239161 fabF 7143646 fabF Escherichia coli ED1a 3-oxoacyl-(acyl carrier protein) synthase II YP_002397259.1 1237920 D 585397 CDS YP_002397260.1 218689048 7144118 1239281..1240090 1 NC_011745.1 catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate; 4-amino-4-deoxychorismate lyase 1240090 pabC 7144118 pabC Escherichia coli ED1a 4-amino-4-deoxychorismate lyase YP_002397260.1 1239281 D 585397 CDS YP_002397261.1 218689049 7144037 1240093..1241115 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 1241115 yceG 7144037 yceG Escherichia coli ED1a hypothetical protein YP_002397261.1 1240093 D 585397 CDS YP_002397262.1 218689050 7142738 1241105..1241746 1 NC_011745.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 1241746 tmk 7142738 tmk Escherichia coli ED1a thymidylate kinase YP_002397262.1 1241105 D 585397 CDS YP_002397263.1 218689051 7141562 1241743..1242747 1 NC_011745.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 1242747 holB 7141562 holB Escherichia coli ED1a DNA polymerase III subunit delta' YP_002397263.1 1241743 D 585397 CDS YP_002397264.1 218689052 7139911 1242758..1243555 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8505303, 8509334, 10747959; Product type pe : putative enzyme; putative metallodependent hydrolase 1243555 ycfH 7139911 ycfH Escherichia coli ED1a putative metallodependent hydrolase YP_002397264.1 1242758 D 585397 CDS YP_002397265.1 218689053 7141946 1243850..1245283 1 NC_011745.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system glucose-specific transporter subunits IIBC 1245283 ptsG 7141946 ptsG Escherichia coli ED1a PTS system glucose-specific transporter subunits IIBC YP_002397265.1 1243850 D 585397 CDS YP_002397266.1 218689054 7141206 complement(1245343..1247532) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90286919, 3032906, 10529396; Product type t : transporter; ferric-rhodotorulic acid outer membrane transporter 1247532 fhuE 7141206 fhuE Escherichia coli ED1a ferric-rhodotorulic acid outer membrane transporter YP_002397266.1 1245343 R 585397 CDS YP_002397267.1 218689055 7144173 1247866..1248225 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15703176, 10493123, 2162465; Product type e : enzyme; purine nucleoside phosphoramidase 1248225 hinT 7144173 hinT Escherichia coli ED1a purine nucleoside phosphoramidase YP_002397267.1 1247866 D 585397 CDS YP_002397268.1 218689056 7139884 1248228..1248605 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1248605 ycfL 7139884 ycfL Escherichia coli ED1a hypothetical protein YP_002397268.1 1248228 D 585397 CDS YP_002397269.1 218689057 7141948 1248619..1249260 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative outer membrane lipoprotein 1249260 ycfM 7141948 ycfM Escherichia coli ED1a putative outer membrane lipoprotein YP_002397269.1 1248619 D 585397 CDS YP_002397270.1 218689058 7141949 1249241..1250065 1 NC_011745.1 catalyzes the phosphorylation of thiamine to thiamine phosphate; thiamine kinase 1250065 thiK 7141949 thiK Escherichia coli ED1a thiamine kinase YP_002397270.1 1249241 D 585397 CDS YP_002397271.1 218689059 7141950 1250076..1251101 1 NC_011745.1 hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides; beta-hexosaminidase 1251101 nagZ 7141950 nagZ Escherichia coli ED1a beta-hexosaminidase YP_002397271.1 1250076 D 585397 CDS YP_002397272.1 218689060 7140341 1251124..1251666 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1251666 ycfP 7140341 ycfP Escherichia coli ED1a hypothetical protein YP_002397272.1 1251124 D 585397 CDS YP_002397273.1 218689061 7141951 1252065..1253369 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14766919, 20130027, 81256452, 92296775, 94042945, 99441207, 6265208; Product type e : enzyme; respiratory NADH dehydrogenase 2/cupric reductase 1253369 ndh 7141951 ndh Escherichia coli ED1a respiratory NADH dehydrogenase 2/cupric reductase YP_002397273.1 1252065 D 585397 CDS YP_002397274.1 218689062 7140371 1253596..1254135 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6265208, 7984428; hypothetical protein 1254135 ycfJ 7140371 ycfJ Escherichia coli ED1a hypothetical protein YP_002397274.1 1253596 D 585397 CDS YP_002397275.1 218689063 7141947 complement(1254197..1254829) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1254829 ycfQ 7141947 ycfQ Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002397275.1 1254197 R 585397 CDS YP_002397276.1 218689064 7141952 1255070..1255327 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14727089; hypothetical protein 1255327 ycfR 7141952 ycfR Escherichia coli ED1a hypothetical protein YP_002397276.1 1255070 D 585397 CDS YP_002397277.1 218689065 7141953 complement(1255410..1256372) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1256372 ycfS 7141953 ycfS Escherichia coli ED1a hypothetical protein YP_002397277.1 1255410 R 585397 CDS YP_002397278.1 218689066 7141954 complement(1256515..1259961) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14602898, 90158497, 92107993, 8465200; Product type f : factor; transcription-repair coupling factor 1259961 mfd 7141954 mfd Escherichia coli ED1a transcription-repair coupling factor YP_002397278.1 1256515 R 585397 CDS YP_002397279.1 218689067 7142263 complement(1260089..1261162) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1261162 ycfT 7142263 ycfT Escherichia coli ED1a hypothetical protein YP_002397279.1 1260089 R 585397 CDS YP_002397280.1 218689068 7141955 1261424..1262623 1 NC_011745.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolC 1262623 lolC 7141955 lolC Escherichia coli ED1a outer membrane-specific lipoprotein transporter subunit LolC YP_002397280.1 1261424 D 585397 CDS YP_002397281.1 218689069 7141902 1262616..1263317 1 NC_011745.1 outer membrane specific; part of transporter complex lolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone; lipoprotein transporter ATP-binding subunit 1263317 lolD 7141902 lolD Escherichia coli ED1a lipoprotein transporter ATP-binding subunit YP_002397281.1 1262616 D 585397 CDS YP_002397282.1 218689070 7141903 1263317..1264561 1 NC_011745.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolE 1264561 lolE 7141903 lolE Escherichia coli ED1a outer membrane-specific lipoprotein transporter subunit LolE YP_002397282.1 1263317 D 585397 CDS YP_002397283.1 218689071 7141904 1264590..1265501 1 NC_011745.1 catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine; N-acetyl-D-glucosamine kinase 1265501 ycfX 7141904 ycfX Escherichia coli ED1a N-acetyl-D-glucosamine kinase YP_002397283.1 1264590 D 585397 CDS YP_002397284.1 218689072 7141956 1265517..1266338 1 NC_011745.1 Modulates the activities of several enzymes which are inactive in their acetylated form; NAD-dependent deacetylase 1266338 cobB 7141956 cobB Escherichia coli ED1a NAD-dependent deacetylase YP_002397284.1 1265517 D 585397 CDS YP_002397285.1 218689073 7142032 complement(1266464..1267252) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1267252 ycfZ 7142032 ycfZ Escherichia coli ED1a hypothetical protein YP_002397285.1 1266464 R 585397 CDS YP_002397286.1 218689074 7141957 complement(1267249..1267710) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1267710 ymfA 7141957 ymfA Escherichia coli ED1a hypothetical protein YP_002397286.1 1267249 R 585397 CDS YP_002397287.1 218689075 7140977 complement(1267768..1268814) 1 NC_011745.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotD is a periplasmic component that binds the substrate; spermidine/putrescine ABC transporter periplasmic substrate-binding protein 1268814 potD 7140977 potD Escherichia coli ED1a spermidine/putrescine ABC transporter periplasmic substrate-binding protein YP_002397287.1 1267768 R 585397 CDS YP_002397288.1 218689076 7139086 complement(1268811..1269605) 1 NC_011745.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component; spermidine/putrescine ABC transporter membrane protein 1269605 potC 7139086 potC Escherichia coli ED1a spermidine/putrescine ABC transporter membrane protein YP_002397288.1 1268811 R 585397 CDS YP_002397289.1 218689077 7139085 complement(1269602..1270429) 1 NC_011745.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component; spermidine/putrescine ABC transporter membrane protein 1270429 potB 7139085 potB Escherichia coli ED1a spermidine/putrescine ABC transporter membrane protein YP_002397289.1 1269602 R 585397 CDS YP_002397290.1 218689078 7139084 complement(1270443..1271579) 1 NC_011745.1 functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase; putrescine/spermidine ABC transporter ATPase protein 1271579 potA 7139084 potA Escherichia coli ED1a putrescine/spermidine ABC transporter ATPase protein YP_002397290.1 1270443 R 585397 CDS YP_002397291.1 218689079 7139083 complement(1271558..1271809) 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 1271809 7139083 ECED1_1270 Escherichia coli ED1a hypothetical protein YP_002397291.1 1271558 R 585397 CDS YP_002397292.1 218689080 7142532 1271829..1273055 1 NC_011745.1 catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T 1273055 pepT 7142532 pepT Escherichia coli ED1a peptidase T YP_002397292.1 1271829 D 585397 CDS YP_002397293.1 218689081 7144065 complement(1273104..1274225) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1274225 ycfD 7144065 ycfD Escherichia coli ED1a hypothetical protein YP_002397293.1 1273104 R 585397 CDS YP_002397294.1 218689082 7141945 complement(1274301..1275761) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92105017; Product type r : regulator; sensor protein PhoQ 1275761 phoQ 7141945 phoQ Escherichia coli ED1a sensor protein PhoQ YP_002397294.1 1274301 R 585397 CDS YP_002397295.1 218689083 7144107 complement(1275761..1276432) 1 NC_011745.1 response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress; DNA-binding transcriptional regulator PhoP 1276432 phoP 7144107 phoP Escherichia coli ED1a DNA-binding transcriptional regulator PhoP YP_002397295.1 1275761 R 585397 CDS YP_002397296.1 218689084 7144106 complement(1276601..1277971) 1 NC_011745.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 1277971 purB 7144106 purB Escherichia coli ED1a adenylosuccinate lyase YP_002397296.1 1276601 R 585397 CDS YP_002397297.1 218689085 7141214 complement(1277975..1278616) 1 NC_011745.1 HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis; hypothetical protein 1278616 hflD 7141214 hflD Escherichia coli ED1a hypothetical protein YP_002397297.1 1277975 R 585397 CDS YP_002397298.1 218689086 7139879 complement(1278652..1279758) 1 NC_011745.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 1279758 mnmA 7139879 mnmA Escherichia coli ED1a tRNA-specific 2-thiouridylase MnmA YP_002397298.1 1278652 R 585397 CDS YP_002397299.1 218689087 7140818 complement(1279812..1280273) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15292217; Product type e : enzyme; bifunctional thiamin pyrimidine pyrophosphate hydrolase and thiamin pyrophosphate hydrolase 1280273 ymfB 7140818 ymfB Escherichia coli ED1a bifunctional thiamin pyrimidine pyrophosphate hydrolase and thiamin pyrophosphate hydrolase YP_002397299.1 1279812 R 585397 CDS YP_002397300.1 218689088 7140978 complement(1280283..1280936) 1 NC_011745.1 catalyzes the formation of pseudouridine from uracil-2457 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase E 1280936 ymfC 7140978 ymfC Escherichia coli ED1a 23S rRNA pseudouridine synthase E YP_002397300.1 1280283 R 585397 CDS YP_002397301.1 218689089 7140979 1281108..1282358 1 NC_011745.1 Converts isocitrate to alpha ketoglutarate; isocitrate dehydrogenase 1282358 icd 7140979 icd Escherichia coli ED1a isocitrate dehydrogenase YP_002397301.1 1281108 D 585397 CDS YP_002397302.1 218689090 7141174 complement(1282795..1283298) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 1283298 insB 7141174 insB Escherichia coli ED1a IS1 transposase InsAB' YP_002397302.1 1282795 R 585397 CDS YP_002397303.1 218689091 7141140 complement(1283217..1283492) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 1283492 insA 7141140 insA Escherichia coli ED1a IS1 repressor protein InsA YP_002397303.1 1283217 R 585397 CDS YP_002397304.1 218689092 7141117 complement(1283543..1285537) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative side tail fiber protein from lambdoid prophage 1285537 7141117 ECED1_1284 Escherichia coli ED1a putative side tail fiber protein from lambdoid prophage YP_002397304.1 1283543 R 585397 CDS YP_002397305.1 218689093 7142535 1286469..1286744 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 1286744 insA 7142535 insA Escherichia coli ED1a IS1 repressor protein InsA YP_002397305.1 1286469 D 585397 CDS YP_002397306.1 218689094 7141118 1286663..1287166 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 1287166 insB 7141118 insB Escherichia coli ED1a IS1 transposase InsAB' YP_002397306.1 1286663 D 585397 CDS YP_002397307.1 218689095 7141141 1287376..1287678 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS600 1287678 insM 7141141 insM Escherichia coli ED1a transposase ORF A, IS600 YP_002397307.1 1287376 D 585397 CDS YP_002397308.1 218689096 7141165 1287714..1288532 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS600 1288532 7141165 ECED1_1290 Escherichia coli ED1a transposase ORF B, IS600 YP_002397308.1 1287714 D 585397 CDS YP_002397309.1 218689097 7142536 1288438..1288809 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1288809 7142536 ECED1_1291 Escherichia coli ED1a hypothetical protein YP_002397309.1 1288438 D 585397 CDS YP_002397310.1 218689098 7142537 1288822..1289115 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1289115 7142537 ECED1_1292 Escherichia coli ED1a hypothetical protein YP_002397310.1 1288822 D 585397 CDS YP_002397311.1 218689099 7142538 complement(1289207..1290064) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12654809, 10085045; Product type m : membrane component; iron transporter inner membrane component 1290064 sitD 7142538 sitD Escherichia coli ED1a iron transporter inner membrane component YP_002397311.1 1289207 R 585397 CDS YP_002397312.1 218689100 7143801 complement(1290061..1290918) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12654809, 10085045; Product type m : membrane component; iron transporter inner membrane component 1290918 sitC 7143801 sitC Escherichia coli ED1a iron transporter inner membrane component YP_002397312.1 1290061 R 585397 CDS YP_002397313.1 218689101 7143800 complement(1290915..1291742) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12654809, 10085045; Product type m : membrane component; iron transport protein, ATP-binding protein 1291742 sitB 7143800 sitB Escherichia coli ED1a iron transport protein, ATP-binding protein YP_002397313.1 1290915 R 585397 CDS YP_002397314.1 218689102 7143799 complement(1291742..1292656) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12654809, 10085045; Product type t : transporter; iron transport protein, periplasmic-binding protein 1292656 sitA 7143799 sitA Escherichia coli ED1a iron transport protein, periplasmic-binding protein YP_002397314.1 1291742 R 585397 CDS YP_002397315.1 218689103 7143798 1293069..1293653 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative transcriptional regulator 1293653 7143798 ECED1_1297 Escherichia coli ED1a putative transcriptional regulator YP_002397315.1 1293069 D 585397 CDS YP_002397316.1 218689104 7142539 complement(1293678..1293965) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acetyltransferase (fragment) 1293965 7142539 ECED1_1298 Escherichia coli ED1a putative acetyltransferase (fragment) YP_002397316.1 1293678 R 585397 CDS YP_002397317.1 218689105 7140222 complement(1295009..1295413) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1295413 ycgX 7140222 ycgX Escherichia coli ED1a hypothetical protein YP_002397317.1 1295009 R 585397 CDS YP_002397318.1 218689106 7141968 complement(1295634..1296365) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1296365 ycgE 7141968 ycgE Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002397318.1 1295634 R 585397 CDS YP_002397319.1 218689107 7141959 complement(1296570..1297781) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16533062, 15453820; Product type pe : putative enzyme; putative blue-light sensing cyclic-di-GMP phosphodiesterase 1297781 ycgF 7141959 ycgF Escherichia coli ED1a putative blue-light sensing cyclic-di-GMP phosphodiesterase YP_002397319.1 1296570 R 585397 CDS YP_002397320.1 218689108 7141960 1298094..1298330 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1298330 ycgZ 7141960 ycgZ Escherichia coli ED1a hypothetical protein YP_002397320.1 1298094 D 585397 CDS YP_002397321.1 218689109 7141969 1298373..1298645 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1298645 ymgA 7141969 ymgA Escherichia coli ED1a hypothetical protein YP_002397321.1 1298373 D 585397 CDS YP_002397322.1 218689110 7140981 1298674..1298940 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1298940 ymgB 7140981 ymgB Escherichia coli ED1a hypothetical protein YP_002397322.1 1298674 D 585397 CDS YP_002397323.1 218689111 7140982 1299053..1299301 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1299301 ymgC 7140982 ymgC Escherichia coli ED1a hypothetical protein YP_002397323.1 1299053 D 585397 CDS YP_002397324.1 218689112 7141961 1300624..1300842 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1300842 ymgF 7141961 ymgF Escherichia coli ED1a hypothetical protein YP_002397324.1 1300624 D 585397 CDS YP_002397325.1 218689113 7140986 1301240..1301419 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1301419 7140986 ECED1_1310 Escherichia coli ED1a hypothetical protein YP_002397325.1 1301240 D 585397 CDS YP_002397326.1 218689114 7142541 1301723..1302085 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1302085 7142541 ECED1_1311 Escherichia coli ED1a hypothetical protein YP_002397326.1 1301723 D 585397 CDS YP_002397327.1 218689115 7142542 1302231..1302758 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1302758 7142542 ECED1_1312 Escherichia coli ED1a hypothetical protein YP_002397327.1 1302231 D 585397 CDS YP_002397328.1 218689116 7142543 complement(1302817..1303146) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1303146 ymgD 7142543 ymgD Escherichia coli ED1a hypothetical protein YP_002397328.1 1302817 R 585397 CDS YP_002397329.1 218689117 7140984 complement(1303156..1303431) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1303431 ymgG 7140984 ymgG Escherichia coli ED1a hypothetical protein YP_002397329.1 1303156 R 585397 CDS YP_002397330.1 218689118 7140304 complement(1304792..1305058) 1 NC_011745.1 works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell; cell division topological specificity factor MinE 1305058 minE 7140304 minE Escherichia coli ED1a cell division topological specificity factor MinE YP_002397330.1 1304792 R 585397 CDS YP_002397331.1 218689119 7138986 complement(1305062..1305874) 1 NC_011745.1 ATPase; with MinC inhibits cell division by blocking formation of the polar Z ring septums; cell division inhibitor MinD 1305874 minD 7138986 minD Escherichia coli ED1a cell division inhibitor MinD YP_002397331.1 1305062 R 585397 CDS YP_002397332.1 218689120 7138985 complement(1305898..1306593) 1 NC_011745.1 blocks the formation of polar Z-ring septums; septum formation inhibitor 1306593 minC 7138985 minC Escherichia coli ED1a septum formation inhibitor YP_002397332.1 1305898 R 585397 CDS YP_002397333.1 218689121 7138984 1307113..1307481 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1307481 ycgJ 7138984 ycgJ Escherichia coli ED1a hypothetical protein YP_002397333.1 1307113 D 585397 CDS YP_002397334.1 218689122 7141962 complement(1307601..1308002) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1308002 ycgK 7141962 ycgK Escherichia coli ED1a hypothetical protein YP_002397334.1 1307601 R 585397 CDS YP_002397335.1 218689123 7141963 1308211..1308537 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1308537 ycgL 7141963 ycgL Escherichia coli ED1a hypothetical protein YP_002397335.1 1308211 D 585397 CDS YP_002397336.1 218689124 7141964 1308609..1309268 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15551868; Product type pe : putative enzyme; hypothetical protein 1309268 ycgM 7141964 ycgM Escherichia coli ED1a hypothetical protein YP_002397336.1 1308609 D 585397 CDS YP_002397337.1 218689125 7141965 1309360..1309806 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1309806 ycgN 7141965 ycgN Escherichia coli ED1a hypothetical protein YP_002397337.1 1309360 D 585397 CDS YP_002397338.1 218689126 7140748 1310605..1311024 1 NC_011745.1 binds with UmuC protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuD 1311024 umuD 7140748 umuD Escherichia coli ED1a DNA polymerase V subunit UmuD YP_002397338.1 1310605 D 585397 CDS YP_002397339.1 218689127 7138976 1311024..1312286 1 NC_011745.1 binds processed UmuD protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuC 1312286 umuC 7138976 umuC Escherichia coli ED1a DNA polymerase V subunit UmuC YP_002397339.1 1311024 D 585397 CDS YP_002397340.1 218689128 7138894 complement(1312331..1312861) 1 NC_011745.1 disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein; disulfide bond formation protein B 1312861 dsbB 7138894 dsbB Escherichia coli ED1a disulfide bond formation protein B YP_002397340.1 1312331 R 585397 CDS YP_002397341.1 218689129 7140522 complement(1313007..1314548) 1 NC_011745.1 involved in regulation of intracellular pH under alkaline conditions; sodium/proton antiporter 1314548 nhaB 7140522 nhaB Escherichia coli ED1a sodium/proton antiporter YP_002397341.1 1313007 R 585397 CDS YP_002397342.1 218689130 7140383 1314770..1315489 1 NC_011745.1 Multifunctional regulator of fatty acid metabolism; fatty acid metabolism regulator 1315489 fadR 7140383 fadR Escherichia coli ED1a fatty acid metabolism regulator YP_002397342.1 1314770 D 585397 CDS YP_002397343.1 218689131 7144130 complement(1315652..1317184) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; SpoVR family protein 1317184 ycgB 7144130 ycgB Escherichia coli ED1a SpoVR family protein YP_002397343.1 1315652 R 585397 CDS YP_002397344.1 218689132 7141958 1317514..1318812 1 NC_011745.1 catalyzes the oxidative deamination of D-amino acids; D-amino acid dehydrogenase small subunit 1318812 dadA 7141958 dadA Escherichia coli ED1a D-amino acid dehydrogenase small subunit YP_002397344.1 1317514 D 585397 CDS YP_002397345.1 218689133 7143056 1318822..1319892 1 NC_011745.1 catabolic enzyme, converts L-alanine to D-alanine which is then oxidized to pyruvate by dadA; alanine racemase 1319892 dadX 7143056 dadX Escherichia coli ED1a alanine racemase YP_002397345.1 1318822 D 585397 CDS YP_002397346.1 218689134 7143057 complement(1319949..1321685) 1 NC_011745.1 the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli; potassium/proton antiporter 1321685 cvrA 7143057 cvrA Escherichia coli ED1a potassium/proton antiporter YP_002397346.1 1319949 R 585397 CDS YP_002397347.1 218689135 7142092 complement(1321780..1322694) 1 NC_011745.1 catalyzes the release of D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine; L,D-carboxypeptidase A 1322694 ldcA 7142092 ldcA Escherichia coli ED1a L,D-carboxypeptidase A YP_002397347.1 1321780 R 585397 CDS YP_002397348.1 218689136 7141869 1322794..1323405 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98317285; Product type e : enzyme; lytic murein endotransglycosylase E 1323405 emtA 7141869 emtA Escherichia coli ED1a lytic murein endotransglycosylase E YP_002397348.1 1322794 D 585397 CDS YP_002397349.1 218689137 7139791 complement(1323407..1324141) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11031114; Product type cp : cell process; flagellar function protein 1324141 ycgR 7139791 ycgR Escherichia coli ED1a flagellar function protein YP_002397349.1 1323407 R 585397 CDS YP_002397350.1 218689138 7141967 1324342..1324596 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative inner membrane protein with transglycosylase-associated domain 1324596 ymgE 7141967 ymgE Escherichia coli ED1a putative inner membrane protein with transglycosylase-associated domain YP_002397350.1 1324342 D 585397 CDS YP_002397351.1 218689139 7140985 complement(1324646..1326637) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative outer membrane receptor, probably tonB dependent 1326637 prrA 7140985 prrA Escherichia coli ED1a putative outer membrane receptor, probably tonB dependent YP_002397351.1 1324646 R 585397 CDS YP_002397352.1 218689140 7141186 complement(1326642..1327496) 1 NC_011745.1 involved in molybdenum transport; molybdenum transport protein ModD 1327496 modD 7141186 modD Escherichia coli ED1a molybdenum transport protein ModD YP_002397352.1 1326642 R 585397 CDS YP_002397353.1 218689141 7139006 complement(1327493..1328305) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative SAM-dependent methyltransferase 1328305 7139006 ECED1_1340 Escherichia coli ED1a putative SAM-dependent methyltransferase YP_002397353.1 1327493 R 585397 CDS YP_002397354.1 218689142 7142544 complement(1328315..1329073) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ABC transporter ATP-binding protein 1329073 7142544 ECED1_1341 Escherichia coli ED1a putative ABC transporter ATP-binding protein YP_002397354.1 1328315 R 585397 CDS YP_002397355.1 218689143 7142545 complement(1329070..1330050) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative ABC transporter permease 1330050 7142545 ECED1_1342 Escherichia coli ED1a putative ABC transporter permease YP_002397355.1 1329070 R 585397 CDS YP_002397356.1 218689144 7142546 complement(1330050..1331114) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter periplasmic binding protein 1331114 7142546 ECED1_1343 Escherichia coli ED1a putative ABC transporter periplasmic binding protein YP_002397356.1 1330050 R 585397 CDS YP_002397357.1 218689145 7140804 complement(1333425..1334843) 1 NC_011745.1 phosphotransferaese subunit; phosphorylates dihydroxyacetone along with DhaK/DhaL; dihydroxyacetone kinase subunit M 1334843 dhaH 7140804 dhaH Escherichia coli ED1a dihydroxyacetone kinase subunit M YP_002397357.1 1333425 R 585397 CDS YP_002397358.1 218689146 7143110 complement(1334854..1335486) 1 NC_011745.1 with DhaK and DhaM catalyzes the phosphorylation of dihydroxyacetone; dihydroxyacetone kinase subunit DhaL 1335486 dhaL 7143110 dhaL Escherichia coli ED1a dihydroxyacetone kinase subunit DhaL YP_002397358.1 1334854 R 585397 CDS YP_002397359.1 218689147 7143112 complement(1335497..1336567) 1 NC_011745.1 with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase; dihydroxyacetone kinase subunit DhaK 1336567 dhaK 7143112 dhaK Escherichia coli ED1a dihydroxyacetone kinase subunit DhaK YP_002397359.1 1335497 R 585397 CDS YP_002397360.1 218689148 7143111 1336795..1338714 1 NC_011745.1 Positively regulates the dhaKLM operon from a sigma-70 promoter; DNA-binding transcriptional regulator DhaR 1338714 dhaR 7143111 dhaR Escherichia coli ED1a DNA-binding transcriptional regulator DhaR YP_002397360.1 1336795 D 585397 CDS YP_002397361.1 218689149 7143113 complement(1338751..1338981) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1338981 7143113 ECED1_1350 Escherichia coli ED1a hypothetical protein YP_002397361.1 1338751 R 585397 CDS YP_002397362.1 218689150 7142548 complement(1339119..1340210) 1 NC_011745.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 1340210 ychF 7142548 ychF Escherichia coli ED1a GTP-dependent nucleic acid-binding protein EngD YP_002397362.1 1339119 R 585397 CDS YP_002397363.1 218689151 7141972 complement(1340327..1340911) 1 NC_011745.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 1340911 pth 7141972 pth Escherichia coli ED1a peptidyl-tRNA hydrolase YP_002397363.1 1340327 R 585397 CDS YP_002397364.1 218689152 7141202 1341189..1341467 1 NC_011745.1 YchH; transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria; ychH presents a class II promoter to bind CRP; unknown function; hypothetical protein 1341467 ychH 7141202 ychH Escherichia coli ED1a hypothetical protein YP_002397364.1 1341189 D 585397 CDS YP_002397365.1 218689153 7141973 complement(1341522..1343201) 1 NC_011745.1 putative role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport; putative sulfate transporter YchM 1343201 ychM 7141973 ychM Escherichia coli ED1a putative sulfate transporter YchM YP_002397365.1 1341522 R 585397 CDS YP_002397366.1 218689154 7141975 complement(1343326..1344273) 1 NC_011745.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 1344273 prsA 7141975 prsA Escherichia coli ED1a ribose-phosphate pyrophosphokinase YP_002397366.1 1343326 R 585397 CDS YP_002397367.1 218689155 7141187 complement(1344424..1345275) 1 NC_011745.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 1345275 ipk 7141187 ipk Escherichia coli ED1a 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase YP_002397367.1 1344424 R 585397 CDS YP_002397368.1 218689156 7142465 complement(1345275..1345898) 1 NC_011745.1 Incorporates lipoproteins in the outer membrane after they are released by the LolA protein; outer membrane lipoprotein LolB 1345898 lolB 7142465 lolB Escherichia coli ED1a outer membrane lipoprotein LolB YP_002397368.1 1345275 R 585397 CDS YP_002397369.1 218689157 7141901 1346114..1347370 1 NC_011745.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 1347370 hemA 7141901 hemA Escherichia coli ED1a glutamyl-tRNA reductase YP_002397369.1 1346114 D 585397 CDS YP_002397370.1 218689158 7139865 1347412..1348494 1 NC_011745.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 1348494 prfA 7139865 prfA Escherichia coli ED1a peptide chain release factor 1 YP_002397370.1 1347412 D 585397 CDS YP_002397371.1 218689159 7139115 1348494..1349327 1 NC_011745.1 HemK; PrmC; transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 1349327 prmC 7139115 prmC Escherichia coli ED1a N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase YP_002397371.1 1348494 D 585397 CDS YP_002397372.1 218689160 7139126 1349324..1349716 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10322010; Product type pr : putative regulator; putative transcriptional regulator 1349716 ychQ 7139126 ychQ Escherichia coli ED1a putative transcriptional regulator YP_002397372.1 1349324 D 585397 CDS YP_002397373.1 218689161 7141978 1349720..1350529 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10322010; Product type pr : putative regulator; putative transcriptional regulator 1350529 ychA 7141978 ychA Escherichia coli ED1a putative transcriptional regulator YP_002397373.1 1349720 D 585397 CDS YP_002397374.1 218689162 7141970 1350565..1351419 1 NC_011745.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 1351419 kdsA 7141970 kdsA Escherichia coli ED1a 2-dehydro-3-deoxyphosphooctonate aldolase YP_002397374.1 1350565 D 585397 CDS YP_002397375.1 218689163 7142498 complement(1351568..1351675) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type f : factor; toxic polypeptide, small 1351675 ldrB 7142498 ldrB Escherichia coli ED1a toxic polypeptide, small YP_002397375.1 1351568 R 585397 CDS YP_002397376.1 218689164 7140749 complement(1352080..1353180) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93266586, 94193576, 94292460; Product type t : transporter; calcium/sodium:proton antiporter 1353180 chaA 7140749 chaA Escherichia coli ED1a calcium/sodium:proton antiporter YP_002397376.1 1352080 R 585397 CDS YP_002397377.1 218689165 7139329 1353450..1353680 1 NC_011745.1 in Escherichia coli this protein putatively regulates the sodium/proton (also pH-independent calcium/proton) antiporter chaA; has weak affinity for calcium and magnesium ions; cation transport regulator 1353680 chaB 7139329 chaB Escherichia coli ED1a cation transport regulator YP_002397377.1 1353450 D 585397 CDS YP_002397378.1 218689166 7139330 1353817..1354533 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type r : regulator; regulatory protein for cation transport 1354533 chaC 7139330 chaC Escherichia coli ED1a regulatory protein for cation transport YP_002397378.1 1353817 D 585397 CDS YP_002397379.1 218689167 7139331 complement(1354577..1354930) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1354930 ychN 7139331 ychN Escherichia coli ED1a hypothetical protein YP_002397379.1 1354577 R 585397 CDS YP_002397380.1 218689168 7141976 1355256..1356509 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7567469; Product type pf : putative factor; hypothetical protein 1356509 ychP 7141976 ychP Escherichia coli ED1a hypothetical protein YP_002397380.1 1355256 D 585397 CDS YP_002397381.1 218689169 7141977 complement(1356510..1357160) 1 NC_011745.1 two-component response regulator NarL; phosphorylated by NarQ; activates transcription of nitrate and nitrite reductase genes and represses transcription of fumarate reductase; transcriptional regulator NarL 1357160 narL 7141977 narL Escherichia coli ED1a transcriptional regulator NarL YP_002397381.1 1356510 R 585397 CDS YP_002397382.1 218689170 7140362 complement(1357153..1358949) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92276349, 92374842, 94083940, 2649492, 2657652, 2668029; Product type r : regulator; nitrate/nitrite sensor protein NarX 1358949 narX 7140362 narX Escherichia coli ED1a nitrate/nitrite sensor protein NarX YP_002397382.1 1357153 R 585397 CDS YP_002397383.1 218689171 7140368 1358975..1359193 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1359193 7140368 ECED1_1372 Escherichia coli ED1a hypothetical protein YP_002397383.1 1358975 D 585397 CDS YP_002397384.1 218689172 7142549 1359288..1360679 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91258310, 2657652, 2668029; Product type t : transporter; nitrate/nitrite transporter 1360679 narK 7142549 narK Escherichia coli ED1a nitrate/nitrite transporter YP_002397384.1 1359288 D 585397 CDS YP_002397385.1 218689173 7140361 1361072..1364815 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 74167294, 89384449, 92121125, 2233673, 2668029, 2995309, 3053688, 3308846, 6094247; Product type e : enzyme; nitrate reductase 1 subunit alpha 1364815 narG 7140361 narG Escherichia coli ED1a nitrate reductase 1 subunit alpha YP_002397385.1 1361072 D 585397 CDS YP_002397386.1 218689174 7140357 1364812..1366350 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 74167294, 89384449, 92121125, 1321049, 2832376, 3053688, 8383531, 8388253, 8664273, 9516445; Product type c : carrier; nitrate reductase 1, beta (Fe-S) subunit 1366350 narH 7140357 narH Escherichia coli ED1a nitrate reductase 1, beta (Fe-S) subunit YP_002397386.1 1364812 D 585397 CDS YP_002397387.1 218689175 7140358 1366347..1367057 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89384449, 92121125, 9632249, 2832376; Product type f : factor; nitrate reductase 1 minormolybdenum-cofactor-assembly chaperone 1367057 narJ 7140358 narJ Escherichia coli ED1a nitrate reductase 1 minormolybdenum-cofactor-assembly chaperone YP_002397387.1 1366347 D 585397 CDS YP_002397388.1 218689176 7140360 1367057..1367734 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 75114694, 89384449, 92121125, 2832376, 3053688; Product type c : carrier; nitrate reductase 1, gamma (cytochrome b(NR)) subunit 1367734 narI 7140360 narI Escherichia coli ED1a nitrate reductase 1, gamma (cytochrome b(NR)) subunit YP_002397388.1 1367057 D 585397 CDS YP_002397389.1 218689177 7142550 1368148..1368300 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 1368300 7142550 ECED1_1379 Escherichia coli ED1a hypothetical protein YP_002397389.1 1368148 D 585397 CDS YP_002397390.1 218689178 7140628 complement(1369780..1370622) 1 NC_011745.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; formyltetrahydrofolate deformylase 1370622 purU 7140628 purU Escherichia coli ED1a formyltetrahydrofolate deformylase YP_002397390.1 1369780 R 585397 CDS YP_002397391.1 218689179 7141226 complement(1370672..1371130) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1371130 ychJ 7141226 ychJ Escherichia coli ED1a hypothetical protein YP_002397391.1 1370672 R 585397 CDS YP_002397392.1 218689180 7141974 1371204..1372148 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 1372148 rssA 7141974 rssA Escherichia coli ED1a hypothetical protein YP_002397392.1 1371204 D 585397 CDS YP_002397393.1 218689181 7140119 1372240..1373253 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339606, 12912910, 9495753; Product type r : regulator; response regulator of RpoS 1373253 rssB 7140119 rssB Escherichia coli ED1a response regulator of RpoS YP_002397393.1 1372240 D 585397 CDS YP_002397394.1 218689182 7140120 1373455..1374363 1 NC_011745.1 together with GalF subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; UTP--glucose-1-phosphate uridylyltransferase subunit GalU 1374363 galU 7140120 galU Escherichia coli ED1a UTP--glucose-1-phosphate uridylyltransferase subunit GalU YP_002397394.1 1373455 D 585397 CDS YP_002397395.1 218689183 7143156 complement(1374507..1374920) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89056689, 94335643, 95267838, 95286558, 99355427, 2404280, 11298273; Product type r : regulator; global DNA-binding transcriptional dual regulator H-NS 1374920 hns 7143156 hns Escherichia coli ED1a global DNA-binding transcriptional dual regulator H-NS YP_002397395.1 1374507 R 585397 CDS YP_002397396.1 218689184 7139904 1375524..1376141 1 NC_011745.1 catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 1376141 tdk 7139904 tdk Escherichia coli ED1a thymidine kinase YP_002397396.1 1375524 D 585397 CDS YP_002397397.1 218689185 7141161 complement(1377589..1380264) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12783863, 4301680, 89291706, 91200315; Product type e : enzyme; bifunctional acetaldehyde-CoA/alcohol dehydrogenase 1380264 adhE 7141161 adhE Escherichia coli ED1a bifunctional acetaldehyde-CoA/alcohol dehydrogenase YP_002397397.1 1377589 R 585397 CDS YP_002397398.1 218689186 7143660 1380741..1381388 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1381388 ychE 7143660 ychE Escherichia coli ED1a hypothetical protein YP_002397398.1 1380741 D 585397 CDS YP_002397399.1 218689187 7141971 complement(1381546..1381860) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1381860 7141971 ECED1_1394 Escherichia coli ED1a hypothetical protein YP_002397399.1 1381546 R 585397 CDS YP_002397400.1 218689188 7142555 1382126..1383757 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20256410, 86111605, 90256748, 92325017, 2015910, 9298646, 9600841, 2187863, 8740179, 9740056, 10972807; Product type t : transporter; oligopeptide ABC transporter subunit periplasmic-binding protein 1383757 oppA 7142555 oppA Escherichia coli ED1a oligopeptide ABC transporter subunit periplasmic-binding protein YP_002397400.1 1382126 D 585397 CDS YP_002397401.1 218689189 7139981 1383843..1384763 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86111606, 93106975, 2187863; Product type t : transporter; oligopeptide transporter permease 1384763 oppB 7139981 oppB Escherichia coli ED1a oligopeptide transporter permease YP_002397401.1 1383843 D 585397 CDS YP_002397402.1 218689190 7139982 1384778..1385686 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86111606; Product type t : transporter; oligopeptide ABC transporter membrane protein 1385686 oppC 7139982 oppC Escherichia coli ED1a oligopeptide ABC transporter membrane protein YP_002397402.1 1384778 D 585397 CDS YP_002397403.1 218689191 7139983 1385698..1386711 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86111606; Product type t : transporter; oligopeptide transporter ATP-binding protein 1386711 oppD 7139983 oppD Escherichia coli ED1a oligopeptide transporter ATP-binding protein YP_002397403.1 1385698 D 585397 CDS YP_002397404.1 218689192 7139984 1386708..1387712 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86111606; Product type t : transporter; oligopeptide ABC transporter ATP-binding protein 1387712 oppF 7139984 oppF Escherichia coli ED1a oligopeptide ABC transporter ATP-binding protein YP_002397404.1 1386708 D 585397 CDS YP_002397405.1 218689193 7139985 complement(1387765..1388094) 1 NC_011745.1 highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein; dsDNA-mimic protein 1388094 yciU 7139985 yciU Escherichia coli ED1a dsDNA-mimic protein YP_002397405.1 1387765 R 585397 CDS YP_002397406.1 218689194 7141990 complement(1388129..1389589) 1 NC_011745.1 catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol); cardiolipin synthetase 1389589 cls 7141990 cls Escherichia coli ED1a cardiolipin synthetase YP_002397406.1 1388129 R 585397 CDS YP_002397407.1 218689195 7139379 1389621..1389905 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1389905 7139379 ECED1_1402 Escherichia coli ED1a hypothetical protein YP_002397407.1 1389621 D 585397 CDS YP_002397408.1 218689196 7142556 complement(1389960..1391213) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12220501, 12912904, 94224769, 98319474; Product type t : transporter; voltage-gated potassium channel 1391213 kch 7142556 kch Escherichia coli ED1a voltage-gated potassium channel YP_002397408.1 1389960 R 585397 CDS YP_002397409.1 218689197 7142489 complement(1391513..1391809) 1 NC_011745.1 unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity; YciI-like protein 1391809 yciI 7142489 yciI Escherichia coli ED1a YciI-like protein YP_002397409.1 1391513 R 585397 CDS YP_002397410.1 218689198 7141983 1391982..1392749 1 NC_011745.1 membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins; transport protein TonB 1392749 tonB 7141983 tonB Escherichia coli ED1a transport protein TonB YP_002397410.1 1391982 D 585397 CDS YP_002397411.1 218689199 7140651 complement(1392789..1393187) 1 NC_011745.1 YciA; hydrolase that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA; member of the the acyl coenzyme A hydrolase family of proteins; acyl-CoA thioester hydrolase 1393187 yciA 7140651 yciA Escherichia coli ED1a acyl-CoA thioester hydrolase YP_002397411.1 1392789 R 585397 CDS YP_002397412.1 218689200 7141979 complement(1393293..1393832) 1 NC_011745.1 Involved in cell division; probably involved in intracellular septation; intracellular septation protein A 1393832 yciB 7141979 yciB Escherichia coli ED1a intracellular septation protein A YP_002397412.1 1393293 R 585397 CDS YP_002397413.1 218689201 7141980 complement(1393862..1394605) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1394605 yciC 7141980 yciC Escherichia coli ED1a hypothetical protein YP_002397413.1 1393862 R 585397 CDS YP_002397414.1 218689202 7141981 1394960..1395598 1 NC_011745.1 receptor for colicin S4; outer membrane protein W 1395598 ompW 7141981 ompW Escherichia coli ED1a outer membrane protein W YP_002397414.1 1394960 D 585397 CDS YP_002397415.1 218689203 7139976 complement(1395644..1396774) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; phage integrase 1396774 7139976 ECED1_1411 Escherichia coli ED1a phage integrase YP_002397415.1 1395644 R 585397 CDS YP_002397416.1 218689204 7142557 complement(1396752..1397000) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; phage excisionase 1397000 7142557 ECED1_1412 Escherichia coli ED1a phage excisionase YP_002397416.1 1396752 R 585397 CDS YP_002397417.1 218689205 7142559 complement(1397427..1397930) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1849492, 12770720; Product type h : extrachromosomal origin; Insertion element IS1 1/5/6 protein insB 1397930 7142559 ECED1_1414 Escherichia coli ED1a Insertion element IS1 1/5/6 protein insB YP_002397417.1 1397427 R 585397 CDS YP_002397418.1 218689206 7142560 complement(1397849..1398124) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; Transposase ORF A, IS1 1398124 insA 7142560 insA Escherichia coli ED1a Transposase ORF A, IS1 YP_002397418.1 1397849 R 585397 CDS YP_002397419.1 218689207 7141119 1398276..1398452 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1398452 7141119 ECED1_1416 Escherichia coli ED1a hypothetical protein YP_002397419.1 1398276 D 585397 CDS YP_002397420.1 218689208 7142561 1398449..1398964 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative prophage protein 1398964 7142561 ECED1_1417 Escherichia coli ED1a putative prophage protein YP_002397420.1 1398449 D 585397 CDS YP_002397421.1 218689209 7142562 1399895..1400146 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2990907; Product type h : extrachromosomal origin; hypothetical protein 1400146 rem 7142562 rem Escherichia coli ED1a hypothetical protein YP_002397421.1 1399895 D 585397 CDS YP_002397422.1 218689210 7141587 1400493..1401542 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1401542 ydfU 7141587 ydfU Escherichia coli ED1a hypothetical protein YP_002397422.1 1400493 D 585397 CDS YP_002397423.1 218689211 7139270 1401555..1401929 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative crossover junction endodeoxyribonuclease RusA 1401929 7139270 ECED1_1420 Escherichia coli ED1a putative crossover junction endodeoxyribonuclease RusA YP_002397423.1 1401555 D 585397 CDS YP_002397424.1 218689212 7142563 1401926..1402747 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative antitermination protein Q of prophage 1402747 7142563 ECED1_1421 Escherichia coli ED1a putative antitermination protein Q of prophage YP_002397424.1 1401926 D 585397 CDS YP_002397425.1 218689213 7142564 1402887..1403171 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1403171 7142564 ECED1_1422 Escherichia coli ED1a hypothetical protein YP_002397425.1 1402887 D 585397 CDS YP_002397426.1 218689214 7142568 1405815..1407803 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1407803 7142568 ECED1_1426 Escherichia coli ED1a hypothetical protein YP_002397426.1 1405815 D 585397 CDS YP_002397427.1 218689215 7142569 1407988..1408452 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1408452 7142569 ECED1_1427 Escherichia coli ED1a hypothetical protein YP_002397427.1 1407988 D 585397 CDS YP_002397428.1 218689216 7142570 1408528..1408743 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage lysis protein S 1408743 essD 7142570 essD Escherichia coli ED1a putative phage lysis protein S YP_002397428.1 1408528 D 585397 CDS YP_002397429.1 218689217 7139812 1408748..1409737 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1409737 7139812 ECED1_1429 Escherichia coli ED1a hypothetical protein YP_002397429.1 1408748 D 585397 CDS YP_002397430.1 218689218 7142571 1409774..1410307 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-associated lysozyme; Qin prophage 1410307 ydfQ 7142571 ydfQ Escherichia coli ED1a putative membrane-associated lysozyme; Qin prophage YP_002397430.1 1409774 D 585397 CDS YP_002397431.1 218689219 7139265 1410385..1410597 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1410597 7139265 ECED1_1431 Escherichia coli ED1a hypothetical protein YP_002397431.1 1410385 D 585397 CDS YP_002397432.1 218689220 7142572 1410578..1410850 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 1410850 7142572 ECED1_1432 Escherichia coli ED1a hypothetical protein YP_002397432.1 1410578 D 585397 CDS YP_002397433.1 218689221 7142573 1410866..1411444 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Endopeptidase (Lysis protein) from bacteriophage origin 1411444 rz 7142573 rz Escherichia coli ED1a Endopeptidase (Lysis protein) from bacteriophage origin YP_002397433.1 1410866 D 585397 CDS YP_002397434.1 218689222 7141358 1411441..1411665 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1411665 7141358 ECED1_1435 Escherichia coli ED1a hypothetical protein YP_002397434.1 1411441 D 585397 CDS YP_002397435.1 218689223 7142574 1411626..1411901 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1411901 7142574 ECED1_1436 Escherichia coli ED1a hypothetical protein YP_002397435.1 1411626 D 585397 CDS YP_002397436.1 218689224 7142575 1411995..1412336 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative tonB-like membrane protein from phage origin 1412336 7142575 ECED1_1438 Escherichia coli ED1a putative tonB-like membrane protein from phage origin YP_002397436.1 1411995 D 585397 CDS YP_002397437.1 218689225 7142576 complement(1412468..1412668) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1412668 ynfO 7142576 ynfO Escherichia coli ED1a hypothetical protein YP_002397437.1 1412468 R 585397 CDS YP_002397438.1 218689226 7141016 1412710..1413075 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative endonuclease from phage origin 1413075 7141016 ECED1_1440 Escherichia coli ED1a putative endonuclease from phage origin YP_002397438.1 1412710 D 585397 CDS YP_002397439.1 218689227 7142577 1413367..1413930 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative terminase small subunit from phage origin 1413930 7142577 ECED1_1441 Escherichia coli ED1a putative terminase small subunit from phage origin YP_002397439.1 1413367 D 585397 CDS YP_002397440.1 218689228 7142578 1413927..1415588 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative terminase large subunit from phage origin 1415588 7142578 ECED1_1442 Escherichia coli ED1a putative terminase large subunit from phage origin YP_002397440.1 1413927 D 585397 CDS YP_002397441.1 218689229 7142579 1415652..1417589 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative major head protein/prohead protease from phage origin 1417589 7142579 ECED1_1443 Escherichia coli ED1a putative major head protein/prohead protease from phage origin YP_002397441.1 1415652 D 585397 CDS YP_002397442.1 218689230 7142026 1417634..1417855 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1417855 7142026 ECED1_1444 Escherichia coli ED1a hypothetical protein YP_002397442.1 1417634 D 585397 CDS YP_002397443.1 218689231 7142746 1417801..1419165 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; phage portal protein, HK97 family 1419165 7142746 ECED1_1445 Escherichia coli ED1a phage portal protein, HK97 family YP_002397443.1 1417801 D 585397 CDS YP_002397444.1 218689232 7142747 1419162..1420385 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage portal protein 1420385 7142747 ECED1_1446 Escherichia coli ED1a putative phage portal protein YP_002397444.1 1419162 D 585397 CDS YP_002397445.1 218689233 7142748 1420382..1420708 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1420708 7142748 ECED1_1447 Escherichia coli ED1a hypothetical protein YP_002397445.1 1420382 D 585397 CDS YP_002397446.1 218689234 7142749 1420718..1421068 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; head-tail adaptor from phage origin 1421068 7142749 ECED1_1448 Escherichia coli ED1a head-tail adaptor from phage origin YP_002397446.1 1420718 D 585397 CDS YP_002397447.1 218689235 7142750 1421044..1421511 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative structural component HK97 gp of phage origin 1421511 7142750 ECED1_1449 Escherichia coli ED1a putative structural component HK97 gp of phage origin YP_002397447.1 1421044 D 585397 CDS YP_002397448.1 218689236 7142751 1421508..1421852 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative structural component of phage origin 1421852 7142751 ECED1_1450 Escherichia coli ED1a putative structural component of phage origin YP_002397448.1 1421508 D 585397 CDS YP_002397449.1 218689237 7142752 1421919..1422635 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative major tail subunit of phage origin 1422635 7142752 ECED1_1451 Escherichia coli ED1a putative major tail subunit of phage origin YP_002397449.1 1421919 D 585397 CDS YP_002397450.1 218689238 7142753 1422641..1423015 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative tail assembly protein of phage origin 1423015 7142753 ECED1_1452 Escherichia coli ED1a putative tail assembly protein of phage origin YP_002397450.1 1422641 D 585397 CDS YP_002397451.1 218689239 7142754 1423039..1423320 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1423320 7142754 ECED1_1453 Escherichia coli ED1a hypothetical protein YP_002397451.1 1423039 D 585397 CDS YP_002397452.1 218689240 7142755 1423368..1426610 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11686382, 11282477, 9562894, 8878031; Product type f : factor; tail length tape measure protein 1426610 7142755 ECED1_1454 Escherichia coli ED1a tail length tape measure protein YP_002397452.1 1423368 D 585397 CDS YP_002397453.1 218689241 7142756 1426603..1426944 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11686382, 11282477, 9562894, 8878031; Product type f : factor; minor tail protein M 1426944 7142756 ECED1_1455 Escherichia coli ED1a minor tail protein M YP_002397453.1 1426603 D 585397 CDS YP_002397454.1 218689242 7142757 1427151..1428314 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; outer membrane porin protein from phage origin 1428314 7142757 ECED1_1456 Escherichia coli ED1a outer membrane porin protein from phage origin YP_002397454.1 1427151 D 585397 CDS YP_002397455.1 218689243 7142758 1428504..1429208 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein L 1429208 7142758 ECED1_1457 Escherichia coli ED1a minor tail protein L YP_002397455.1 1428504 D 585397 CDS YP_002397456.1 218689244 7142759 1428958..1429962 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail fiber component K 1429962 7142759 ECED1_1459 Escherichia coli ED1a tail fiber component K YP_002397456.1 1428958 D 585397 CDS YP_002397457.1 218689245 7142760 1429860..1430540 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail assembly protein I 1430540 7142760 ECED1_1460 Escherichia coli ED1a tail assembly protein I YP_002397457.1 1429860 D 585397 CDS YP_002397458.1 218689246 7142763 1433250..1433849 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative Lom-like outer membrane protein of phage origin 1433849 7142763 ECED1_1463 Escherichia coli ED1a putative Lom-like outer membrane protein of phage origin YP_002397458.1 1433250 D 585397 CDS YP_002397459.1 218689247 7142764 1434001..1435509 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative tail fiber protein from phage origin 1435509 7142764 ECED1_1464 Escherichia coli ED1a putative tail fiber protein from phage origin YP_002397459.1 1434001 D 585397 CDS YP_002397460.1 218689248 7142765 1435529..1436107 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1436107 7142765 ECED1_1465 Escherichia coli ED1a hypothetical protein YP_002397460.1 1435529 D 585397 CDS YP_002397461.1 218689249 7142766 complement(1436140..1436436) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1436436 7142766 ECED1_1466 Escherichia coli ED1a hypothetical protein YP_002397461.1 1436140 R 585397 CDS YP_002397462.1 218689250 7142767 complement(1436760..1437566) 1 NC_011745.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 1437566 trpA 7142767 trpA Escherichia coli ED1a tryptophan synthase subunit alpha YP_002397462.1 1436760 R 585397 CDS YP_002397463.1 218689251 7140819 complement(1437566..1438759) 1 NC_011745.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 1438759 trpB 7140819 trpB Escherichia coli ED1a tryptophan synthase subunit beta YP_002397463.1 1437566 R 585397 CDS YP_002397464.1 218689252 7140820 complement(1438771..1440129) 1 NC_011745.1 monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate; bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase 1440129 trpC 7140820 trpC Escherichia coli ED1a bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase YP_002397464.1 1438771 R 585397 CDS YP_002397465.1 218689253 7140821 complement(1440133..1441728) 1 NC_011745.1 bifunctional anthranilate synthase II/anthranilate phosphoribosyltransferase; TrpD; forms a heterotetramer with Trp E and the complex catalyzes the formation of anthranilate from chorismate and glutamine; also catalyzes the formation of N-(5-phospho-D-ribosyl)-anthranilate from athranilate and 5-phospho-alpha-D-ribose 1-diphosphate; functions in tryptophan biosynthesis; bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase 1441728 trpD 7140821 trpD Escherichia coli ED1a bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase YP_002397465.1 1440133 R 585397 CDS YP_002397466.1 218689254 7140822 complement(1441728..1443290) 1 NC_011745.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 1443290 trpE 7140822 trpE Escherichia coli ED1a anthranilate synthase component I YP_002397466.1 1441728 R 585397 CDS YP_002397468.1 218689256 7140824 1443564..1444445 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1444445 yciV 7140824 yciV Escherichia coli ED1a hypothetical protein YP_002397468.1 1443564 D 585397 CDS YP_002397469.1 218689257 7141991 1444442..1445062 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1445062 yciO 7141991 yciO Escherichia coli ED1a hypothetical protein YP_002397469.1 1444442 D 585397 CDS YP_002397470.1 218689258 7141987 1445087..1446979 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1446979 yciQ 7141987 yciQ Escherichia coli ED1a hypothetical protein YP_002397470.1 1445087 D 585397 CDS YP_002397471.1 218689259 7141988 1447192..1448067 1 NC_011745.1 catalyzes the synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA; 23S rRNA pseudouridylate synthase B 1448067 rluB 7141988 rluB Escherichia coli ED1a 23S rRNA pseudouridylate synthase B YP_002397471.1 1447192 D 585397 CDS YP_002397472.1 218689260 7141425 complement(1448107..1448697) 1 NC_011745.1 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide; cob(I)yrinic acid a,c-diamide adenosyltransferase 1448697 btuR 7141425 btuR Escherichia coli ED1a cob(I)yrinic acid a,c-diamide adenosyltransferase YP_002397472.1 1448107 R 585397 CDS YP_002397473.1 218689261 7140469 complement(1448694..1449452) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; short chain dehydrogenase 1449452 yciK 7140469 yciK Escherichia coli ED1a short chain dehydrogenase YP_002397473.1 1448694 R 585397 CDS YP_002397474.1 218689262 7141984 1449672..1450721 1 NC_011745.1 SohB; periplasmic protein; member of the peptidase S49 family; putative periplasmic protease 1450721 sohB 7141984 sohB Escherichia coli ED1a putative periplasmic protease YP_002397474.1 1449672 D 585397 CDS YP_002397475.1 218689263 7143818 complement(1450757..1451008) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3029379, 7567469, 9868784; hypothetical protein 1451008 yciN 7143818 yciN Escherichia coli ED1a hypothetical protein YP_002397475.1 1450757 R 585397 CDS YP_002397476.1 218689264 7141986 1451001..1451156 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 1451156 7141986 ECED1_1480 Escherichia coli ED1a hypothetical protein YP_002397476.1 1451001 D 585397 CDS YP_002397477.1 218689265 7142768 1451388..1453985 1 NC_011745.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 1453985 topA 7142768 topA Escherichia coli ED1a DNA topoisomerase I YP_002397477.1 1451388 D 585397 CDS YP_002397478.1 218689266 7140790 1454195..1455169 1 NC_011745.1 LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation; transcriptional regulator CysB 1455169 cysB 7140790 cysB Escherichia coli ED1a transcriptional regulator CysB YP_002397478.1 1454195 D 585397 CDS YP_002397479.1 218689267 7142108 1455464..1455628 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1455628 7142108 ECED1_1483 Escherichia coli ED1a hypothetical protein YP_002397479.1 1455464 D 585397 CDS YP_002397480.1 218689268 7142769 1455610..1455798 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1455798 7142769 ECED1_1484 Escherichia coli ED1a hypothetical protein YP_002397480.1 1455610 D 585397 CDS YP_002397481.1 218689269 7143643 complement(1458895..1459485) 1 NC_011745.1 catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate; GTP cyclohydrolase II 1459485 ribA 7143643 ribA Escherichia coli ED1a GTP cyclohydrolase II YP_002397481.1 1458895 R 585397 CDS YP_002397482.1 218689270 7141621 1459655..1460419 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89033893, 92104964; Product type e : enzyme; phosphatidylglycerophosphatase B 1460419 pgpB 7141621 pgpB Escherichia coli ED1a phosphatidylglycerophosphatase B YP_002397482.1 1459655 D 585397 CDS YP_002397483.1 218689271 7144079 1460568..1460876 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1460876 yciS 7144079 yciS Escherichia coli ED1a hypothetical protein YP_002397483.1 1460568 D 585397 CDS YP_002397484.1 218689272 7141989 1460883..1462052 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; tetratricopeptide repeat protein 1462052 yciM 7141989 yciM Escherichia coli ED1a tetratricopeptide repeat protein YP_002397484.1 1460883 D 585397 CDS YP_002397485.1 218689273 7141985 1462244..1462981 1 NC_011745.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 1462981 pyrF 7141985 pyrF Escherichia coli ED1a orotidine 5'-phosphate decarboxylase YP_002397485.1 1462244 D 585397 CDS YP_002397486.1 218689274 7141235 1462981..1463307 1 NC_011745.1 involved in start site selection during the initiation of translation; translation initiation factor Sui1 1463307 yciH 7141235 yciH Escherichia coli ED1a translation initiation factor Sui1 YP_002397486.1 1462981 D 585397 CDS YP_002397487.1 218689275 7141982 complement(1463433..1463651) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92078100, 2644204; Product type lp : lipoprotein; lipoprotein 1463651 osmB 7141982 osmB Escherichia coli ED1a lipoprotein YP_002397487.1 1463433 R 585397 CDS YP_002397488.1 218689276 7139987 complement(1463920..1464669) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16451192; Product type r : regulator; DeoR family DNA-binding transcriptional repressor 1464669 deoT 7139987 deoT Escherichia coli ED1a DeoR family DNA-binding transcriptional repressor YP_002397488.1 1463920 R 585397 CDS YP_002397489.1 218689277 7143098 complement(1464759..1464941) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1464941 7143098 ECED1_1495 Escherichia coli ED1a hypothetical protein YP_002397489.1 1464759 R 585397 CDS YP_002397490.1 218689278 7142771 complement(1465080..1467065) 1 NC_011745.1 c-di-GMP phosphodiesterase; probably degrades signalling molecule c-di-GMP; RNase II stability modulator 1467065 gmr 7142771 gmr Escherichia coli ED1a RNase II stability modulator YP_002397490.1 1465080 R 585397 CDS YP_002397491.1 218689279 7142996 complement(1467299..1469230) 1 NC_011745.1 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction; exoribonuclease II 1469230 rnb 7142996 rnb Escherichia coli ED1a exoribonuclease II YP_002397491.1 1467299 R 585397 CDS YP_002397492.1 218689280 7141431 complement(1469298..1470425) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative amidase or amidotransferase 1470425 yciW 7141431 yciW Escherichia coli ED1a putative amidase or amidotransferase YP_002397492.1 1469298 R 585397 CDS YP_002397493.1 218689281 7141992 complement(1470570..1471358) 1 NC_011745.1 Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-(acyl carrier protein) reductase 1471358 fabI 7141992 fabI Escherichia coli ED1a enoyl-(acyl carrier protein) reductase YP_002397493.1 1470570 R 585397 CDS YP_002397494.1 218689282 7144121 1471737..1472402 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional repressor 1472402 7144121 ECED1_1500 Escherichia coli ED1a putative transcriptional repressor YP_002397494.1 1471737 D 585397 CDS YP_002397495.1 218689283 7142772 1472518..1473672 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative efflux protein, membrane fusion (MFP) family 1473672 7142772 ECED1_1501 Escherichia coli ED1a putative efflux protein, membrane fusion (MFP) family YP_002397495.1 1472518 D 585397 CDS YP_002397496.1 218689284 7142773 1473672..1476779 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative efflux pump 1476779 7142773 ECED1_1502 Escherichia coli ED1a putative efflux pump YP_002397496.1 1473672 D 585397 CDS YP_002397497.1 218689285 7142774 1476783..1478156 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative outer membrane channel protein of an efflux system 1478156 7142774 ECED1_1503 Escherichia coli ED1a putative outer membrane channel protein of an efflux system YP_002397497.1 1476783 D 585397 CDS YP_002397498.1 218689286 7142775 1478165..1479328 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 1479328 7142775 ECED1_1504 Escherichia coli ED1a putative transporter YP_002397498.1 1478165 D 585397 CDS YP_002397499.1 218689287 7142776 complement(1479376..1480182) 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 10720487, 9634580; Product type t : transporter; antimicrobial peptide ABC transporter ATP-binding protein 1480182 sapF 7142776 sapF Escherichia coli ED1a antimicrobial peptide ABC transporter ATP-binding protein YP_002397499.1 1479376 R 585397 CDS YP_002397500.1 218689288 7141368 complement(1480184..1481176) 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 10720487, 9634580, 1987159; Product type t : transporter; antimicrobial peptide ABC transporter ATP-binding protein 1481176 sapD 7141368 sapD Escherichia coli ED1a antimicrobial peptide ABC transporter ATP-binding protein YP_002397500.1 1480184 R 585397 CDS YP_002397501.1 218689289 7141367 complement(1481176..1482066) 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 9634580; Product type t : transporter; antimicrobial peptide ABC transporter permease 1482066 sapC 7141367 sapC Escherichia coli ED1a antimicrobial peptide ABC transporter permease YP_002397501.1 1481176 R 585397 CDS YP_002397502.1 218689290 7141366 complement(1482053..1483018) 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 9634580; Product type t : transporter; antimicrobial peptide ABC transporter permease 1483018 sapB 7141366 sapB Escherichia coli ED1a antimicrobial peptide ABC transporter permease YP_002397502.1 1482053 R 585397 CDS YP_002397503.1 218689291 7141365 complement(1483015..1484658) 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 9634580; Product type t : transporter; antimicrobial peptide ABC transporter periplasmic-binding protein 1484658 sapA 7141365 sapA Escherichia coli ED1a antimicrobial peptide ABC transporter periplasmic-binding protein YP_002397503.1 1483015 R 585397 CDS YP_002397504.1 218689292 7141364 complement(1484971..1485216) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1485216 ymjA 7141364 ymjA Escherichia coli ED1a hypothetical protein YP_002397504.1 1484971 R 585397 CDS YP_002397505.1 218689293 7140988 complement(1485643..1486620) 1 NC_011745.1 transcriptional activator for pspABCE which are induced in response to phage proteins, membrane altering stresses, and impaired proton expor; phage shock protein operon transcriptional activator 1486620 pspF 7140988 pspF Escherichia coli ED1a phage shock protein operon transcriptional activator YP_002397505.1 1485643 R 585397 CDS YP_002397506.1 218689294 7141195 1486786..1487454 1 NC_011745.1 involved in maintaining membrane potential under membrane stress conditions; also acts as a negative transcriptional regulator of the phage shock protein (psp) operon(pspABCDE) by regulating the transcriptional activator PspF; phage shock protein PspA 1487454 pspA 7141195 pspA Escherichia coli ED1a phage shock protein PspA YP_002397506.1 1486786 D 585397 CDS YP_002397507.1 218689295 7141190 1487508..1487732 1 NC_011745.1 acts together with PspC to induce psp operon during infection with phage, exposure to ethanol or osmotic shock; forms a complex with PspA and C; PspC is required for PspAB binding; phage shock protein B 1487732 pspB 7141190 pspB Escherichia coli ED1a phage shock protein B YP_002397507.1 1487508 D 585397 CDS YP_002397508.1 218689296 7141191 1487732..1488091 1 NC_011745.1 with PsbB forms toxin/antitoxin pair; activates the psp operon in response to phage infection, exposure to ethanol or osmotic shock; DNA-binding transcriptional activator PspC 1488091 pspC 7141191 pspC Escherichia coli ED1a DNA-binding transcriptional activator PspC YP_002397508.1 1487732 D 585397 CDS YP_002397509.1 218689297 7141192 1488100..1488321 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91295203, 97303082; Product type ph : phenotype; peripheral inner membrane phage-shock protein 1488321 pspD 7141192 pspD Escherichia coli ED1a peripheral inner membrane phage-shock protein YP_002397509.1 1488100 D 585397 CDS YP_002397510.1 218689298 7141193 1488396..1488710 1 NC_011745.1 rhodanese; catalyzes the formation of thiocyanate from thiosulfate and hydrogen cyanide; thiosulfate:cyanide sulfurtransferase 1488710 pspE 7141193 pspE Escherichia coli ED1a thiosulfate:cyanide sulfurtransferase YP_002397510.1 1488396 D 585397 CDS YP_002397511.1 218689299 7141194 1488920..1490599 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glucosyltransferase 1490599 ycjM 7141194 ycjM Escherichia coli ED1a putative glucosyltransferase YP_002397511.1 1488920 D 585397 CDS YP_002397512.1 218689300 7141995 1490613..1491905 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter periplasmic-binding protein transporter 1491905 ycjN 7141995 ycjN Escherichia coli ED1a putative sugar ABC transporter periplasmic-binding protein transporter YP_002397512.1 1490613 D 585397 CDS YP_002397513.1 218689301 7141996 1491926..1492807 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter permease 1492807 ycjO 7141996 ycjO Escherichia coli ED1a putative sugar ABC transporter permease YP_002397513.1 1491926 D 585397 CDS YP_002397514.1 218689302 7141997 1492794..1493636 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter permease 1493636 ycjP 7141997 ycjP Escherichia coli ED1a putative sugar ABC transporter permease YP_002397514.1 1492794 D 585397 CDS YP_002397515.1 218689303 7141998 1493667..1494719 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase, Zn-dependent and NAD(P)-binding 1494719 ycjQ 7141998 ycjQ Escherichia coli ED1a putative oxidoreductase, Zn-dependent and NAD(P)-binding YP_002397515.1 1493667 D 585397 CDS YP_002397516.1 218689304 7141999 1494738..1495526 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative isomerase/epimerase 1495526 ycjR 7141999 ycjR Escherichia coli ED1a putative isomerase/epimerase YP_002397516.1 1494738 D 585397 CDS YP_002397517.1 218689305 7142000 1495536..1496591 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase, NADH-binding 1496591 ycjS 7142000 ycjS Escherichia coli ED1a putative oxidoreductase, NADH-binding YP_002397517.1 1495536 D 585397 CDS YP_002397518.1 218689306 7142001 1496588..1498855 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glycosyl hydrolase/phosphorylase 1498855 ycjT 7142001 ycjT Escherichia coli ED1a putative glycosyl hydrolase/phosphorylase YP_002397518.1 1496588 D 585397 CDS YP_002397519.1 218689307 7142002 1498852..1499511 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11972617; Product type pe : putative enzyme; putative glucose-1-phosphate phosphodismutase 1499511 ycjU 7142002 ycjU Escherichia coli ED1a putative glucose-1-phosphate phosphodismutase YP_002397519.1 1498852 D 585397 CDS YP_002397520.1 218689308 7142003 1499525..1500607 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter ATP-binding protein transporter 1500607 ycjV 7142003 ycjV Escherichia coli ED1a putative sugar ABC transporter ATP-binding protein transporter YP_002397520.1 1499525 D 585397 CDS YP_002397521.1 218689309 7142004 1500652..1501557 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20464934, 89327119, 9721282; Product type t : transporter; outer membrane porin 1501557 ompG 7142004 ompG Escherichia coli ED1a outer membrane porin YP_002397521.1 1500652 D 585397 CDS YP_002397522.1 218689310 7139970 complement(1501608..1502606) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1502606 ycjW 7139970 ycjW Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002397522.1 1501608 R 585397 CDS YP_002397523.1 218689311 7142005 1502763..1504160 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1504160 ycjX 7142005 ycjX Escherichia coli ED1a hypothetical protein YP_002397523.1 1502763 D 585397 CDS YP_002397524.1 218689312 7142006 1504157..1505218 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1505218 ycjF 7142006 ycjF Escherichia coli ED1a hypothetical protein YP_002397524.1 1504157 D 585397 CDS YP_002397525.1 218689313 7141993 1505366..1506907 1 NC_011745.1 regulates genes involved in the biosynthesis and transport of aromatic amino acids; DNA-binding transcriptional regulator TyrR 1506907 tyrR 7141993 tyrR Escherichia coli ED1a DNA-binding transcriptional regulator TyrR YP_002397525.1 1505366 D 585397 CDS YP_002397526.1 218689314 7140853 complement(1506951..1507457) 1 NC_011745.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 1507457 tpx 7140853 tpx Escherichia coli ED1a thiol peroxidase YP_002397526.1 1506951 R 585397 CDS YP_002397527.1 218689315 7140801 1507576..1508541 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11747447, 11747448, 7499381; Product type e : enzyme; L-Ala-D/L-Glu epimerase 1508541 ycjG 7140801 ycjG Escherichia coli ED1a L-Ala-D/L-Glu epimerase YP_002397527.1 1507576 D 585397 CDS YP_002397528.1 218689316 7141994 complement(1508516..1509304) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12511517; Product type e : enzyme; murein peptide amidase A 1509304 mpaA 7141994 mpaA Escherichia coli ED1a murein peptide amidase A YP_002397528.1 1508516 R 585397 CDS YP_002397529.1 218689317 7139014 complement(1509535..1510173) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative NAD(P) binding enzyme 1510173 ymjC 7139014 ymjC Escherichia coli ED1a putative NAD(P) binding enzyme YP_002397529.1 1509535 R 585397 CDS YP_002397530.1 218689318 7142009 1511301..1512200 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 17366475; Product type pr : putative regulator; putative nucleic acid-binding regulator 1512200 ycjZ 7142009 ycjZ Escherichia coli ED1a putative nucleic acid-binding regulator YP_002397530.1 1511301 D 585397 CDS YP_002397531.1 218689319 7142010 1512537..1514150 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10438753, 9495761; Product type t : transporter; murein tripeptide (L-ala-gamma-D-glutamyl-meso-DAP) ABC transporter subunit periplasmic-binding protein 1514150 mppA 7142010 mppA Escherichia coli ED1a murein tripeptide (L-ala-gamma-D-glutamyl-meso-DAP) ABC transporter subunit periplasmic-binding protein YP_002397531.1 1512537 D 585397 CDS YP_002397532.1 218689320 7139016 complement(1514201..1515232) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1515232 ynaI 7139016 ynaI Escherichia coli ED1a hypothetical protein YP_002397532.1 1514201 R 585397 CDS YP_002397533.1 218689321 7140990 1515476..1515733 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1515733 ynaJ 7140990 ynaJ Escherichia coli ED1a hypothetical protein YP_002397533.1 1515476 D 585397 CDS YP_002397534.1 218689322 7140991 complement(1515783..1516733) 1 NC_011745.1 with UspC and UspD is involved in resistance to UV irradiation; universal stress protein UspE 1516733 uspE 7140991 uspE Escherichia coli ED1a universal stress protein UspE YP_002397534.1 1515783 R 585397 CDS YP_002397535.1 218689323 7139146 complement(1516885..1517637) 1 NC_011745.1 Global transcription factor that controls the expression of over 100 target genes in response to anoxia; fumarate/nitrate reduction transcriptional regulator 1517637 fnr 7139146 fnr Escherichia coli ED1a fumarate/nitrate reduction transcriptional regulator YP_002397535.1 1516885 R 585397 CDS YP_002397536.1 218689324 7142153 complement(1517832..1518347) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88067749, 91161525, 94252990, 98125595, 1520330; Product type e : enzyme; O-6-alkylguanine-DNA:cysteine-protein methyltransferase 1518347 ogt 7142153 ogt Escherichia coli ED1a O-6-alkylguanine-DNA:cysteine-protein methyltransferase YP_002397536.1 1517832 R 585397 CDS YP_002397537.1 218689325 7139966 complement(1518358..1518549) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1518549 7139966 ECED1_1546 Escherichia coli ED1a hypothetical protein YP_002397537.1 1518358 R 585397 CDS YP_002397538.1 218689326 7140750 complement(1518879..1519694) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative HTH-type transcriptional regulator 1519694 7140750 ECED1_1547 Escherichia coli ED1a putative HTH-type transcriptional regulator YP_002397538.1 1518879 R 585397 CDS YP_002397539.1 218689327 7142778 1519788..1520819 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative HlyD family secretion protein 1520819 7142778 ECED1_1548 Escherichia coli ED1a putative HlyD family secretion protein YP_002397539.1 1519788 D 585397 CDS YP_002397540.1 218689328 7142779 1520816..1522330 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative drug resistance transporter EmrB/QacA subfamily 1522330 7142779 ECED1_1549 Escherichia coli ED1a putative drug resistance transporter EmrB/QacA subfamily YP_002397540.1 1520816 D 585397 CDS YP_002397541.1 218689329 7142780 1522525..1523088 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1523088 ydaL 7142780 ydaL Escherichia coli ED1a hypothetical protein YP_002397541.1 1522525 D 585397 CDS YP_002397542.1 218689330 7142011 complement(1523109..1524341) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16045609; Product type pe : putative enzyme; putative diguanylate cyclase, GG[D/E]EF domain signalling protein 1524341 ydaM 7142011 ydaM Escherichia coli ED1a putative diguanylate cyclase, GG[D/E]EF domain signalling protein YP_002397542.1 1523109 R 585397 CDS YP_002397543.1 218689331 7142012 1524596..1525579 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; zinc transporter 1525579 zntB 7142012 zntB Escherichia coli ED1a zinc transporter YP_002397543.1 1524596 D 585397 CDS YP_002397544.1 218689332 7142013 1525854..1526027 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1526027 7142013 ECED1_1553 Escherichia coli ED1a hypothetical protein YP_002397544.1 1525854 D 585397 CDS YP_002397545.1 218689333 7140472 1526057..1527430 1 NC_011745.1 exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA; ATP-dependent RNA helicase DbpA 1527430 dbpA 7140472 dbpA Escherichia coli ED1a ATP-dependent RNA helicase DbpA YP_002397545.1 1526057 D 585397 CDS YP_002397546.1 218689334 7143067 complement(1527559..1528494) 1 NC_011745.1 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs; C32 tRNA thiolase 1528494 ydaO 7143067 ydaO Escherichia coli ED1a C32 tRNA thiolase YP_002397546.1 1527559 R 585397 CDS YP_002397547.1 218689335 7142444 complement(1530364..1530732) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative ABC transporter 1530732 7142444 ECED1_1557 Escherichia coli ED1a putative ABC transporter YP_002397547.1 1530364 R 585397 CDS YP_002397548.1 218689336 7142782 complement(1530821..1531255) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12732303, 12381839, 11849540, 9298646; Product type f : factor; stress-induced protein, ATP-binding protein 1531255 uspF 7142782 uspF Escherichia coli ED1a stress-induced protein, ATP-binding protein YP_002397548.1 1530821 R 585397 CDS YP_002397549.1 218689337 7138982 complement(1532895..1536419) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9025293; Product type pe : putative enzyme; putative 2-oxoacid-flavodoxin/oxidoreductase 1536419 ydbK 7138982 ydbK Escherichia coli ED1a putative 2-oxoacid-flavodoxin/oxidoreductase YP_002397549.1 1532895 R 585397 CDS YP_002397550.1 218689338 7142021 1536693..1536959 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1536959 ydbJ 7142021 ydbJ Escherichia coli ED1a hypothetical protein YP_002397550.1 1536693 D 585397 CDS YP_002397551.1 218689339 7142020 complement(1536956..1537378) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12892888, 8349564, 9025293; Product type f : factor; heat-inducible protein 1537378 hslJ 7142020 hslJ Escherichia coli ED1a heat-inducible protein YP_002397551.1 1536956 R 585397 CDS YP_002397552.1 218689340 7140166 complement(1537489..1538478) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 4297266, 89123040, 90198524, 8349564, 9025293; Product type e : enzyme; fermentative D-lactate dehydrogenase, NAD-dependent 1538478 ldhA 7140166 ldhA Escherichia coli ED1a fermentative D-lactate dehydrogenase, NAD-dependent YP_002397552.1 1537489 R 585397 CDS YP_002397553.1 218689341 7141871 1538686..1541325 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1541325 ydbH 7141871 ydbH Escherichia coli ED1a hypothetical protein YP_002397553.1 1538686 D 585397 CDS YP_002397554.1 218689342 7142019 1541322..1541507 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; putative lipoprotein 1541507 ynbE 7142019 ynbE Escherichia coli ED1a putative lipoprotein YP_002397554.1 1541322 D 585397 CDS YP_002397555.1 218689343 7140992 1541515..1541841 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1541841 ydbL 7140992 ydbL Escherichia coli ED1a hypothetical protein YP_002397555.1 1541515 D 585397 CDS YP_002397556.1 218689344 7142022 1542217..1549209 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative cell adhesion autotransported outer membrane protein 1549209 ydbA 7142022 ydbA Escherichia coli ED1a putative cell adhesion autotransported outer membrane protein YP_002397556.1 1542217 D 585397 CDS YP_002397557.1 218689345 7142017 1549428..1550294 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 1550294 ydbC 7142017 ydbC Escherichia coli ED1a putative oxidoreductase YP_002397557.1 1549428 D 585397 CDS YP_002397558.1 218689346 7142018 complement(1550335..1550940) 1 NC_011745.1 FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds; azoreductase 1550940 azoR 7142018 azoR Escherichia coli ED1a azoreductase YP_002397558.1 1550335 R 585397 CDS YP_002397559.1 218689347 7140425 1551198..1555043 1 NC_011745.1 involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain; ATP-dependent RNA helicase HrpA 1555043 hrpA 7140425 hrpA Escherichia coli ED1a ATP-dependent RNA helicase HrpA YP_002397559.1 1551198 D 585397 CDS YP_002397560.1 218689348 7139916 1555316..1556116 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1556116 ydcF 7139916 ydcF Escherichia coli ED1a hypothetical protein YP_002397560.1 1555316 D 585397 CDS YP_002397561.1 218689349 7142025 1556313..1557752 1 NC_011745.1 NAD-linked; aldehyde dehydrogenase A 1557752 aldA 7142025 aldA Escherichia coli ED1a aldehyde dehydrogenase A YP_002397561.1 1556313 D 585397 CDS YP_002397562.1 218689350 7143686 complement(1557794..1558795) 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9622357, 9019141, 1917845, 3780374; Product type e : enzyme; glyceraldehyde-3-phosphate dehydrogenase C 1558795 gapC 7143686 gapC Escherichia coli ED1a glyceraldehyde-3-phosphate dehydrogenase C YP_002397562.1 1557794 R 585397 CDS YP_002397563.1 218689351 7143158 1558984..1559514 1 NC_011745.1 B-type di-heme cytochrome with a major alpha-absorption peak at 561 nm and a minor peak at 555 nm; cytochrome b561 1559514 cybB 7143158 cybB Escherichia coli ED1a cytochrome b561 YP_002397563.1 1558984 D 585397 CDS YP_002397564.1 218689352 7140152 1559759..1559932 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1559932 ydcA 7140152 ydcA Escherichia coli ED1a hypothetical protein YP_002397564.1 1559759 D 585397 CDS YP_002397565.1 218689353 7140809 complement(1560597..1561520) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1561520 ydcI 7140809 ydcI Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002397565.1 1560597 R 585397 CDS YP_002397566.1 218689354 7139224 1561737..1563080 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1563080 ydcJ 7139224 ydcJ Escherichia coli ED1a hypothetical protein YP_002397566.1 1561737 D 585397 CDS YP_002397567.1 218689355 7139225 1563335..1564960 1 NC_011745.1 involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans; glucan biosynthesis protein D 1564960 mdoD 7139225 mdoD Escherichia coli ED1a glucan biosynthesis protein D YP_002397567.1 1563335 D 585397 CDS YP_002397568.1 218689356 7142224 complement(1564881..1565084) 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 1565084 7142224 ECED1_1581 Escherichia coli ED1a hypothetical protein YP_002397568.1 1564881 R 585397 CDS YP_002397569.1 218689357 7142783 1565100..1565324 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1565324 ydcH 7142783 ydcH Escherichia coli ED1a hypothetical protein YP_002397569.1 1565100 D 585397 CDS YP_002397570.1 218689358 7139223 1565387..1565926 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89364711; Product type e : enzyme; ribosomal-protein-L7/L12-serine acetyltransferase 1565926 rimL 7139223 rimL Escherichia coli ED1a ribosomal-protein-L7/L12-serine acetyltransferase YP_002397570.1 1565387 D 585397 CDS YP_002397571.1 218689359 7141419 complement(1565918..1566898) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 1566898 ydcK 7141419 ydcK Escherichia coli ED1a hypothetical protein YP_002397571.1 1565918 R 585397 CDS YP_002397572.1 218689360 7139226 1567022..1568014 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94222856, 2060788; Product type t : transporter; potassium-tellurite ethidium and proflavin transporter 1568014 tehA 7139226 tehA Escherichia coli ED1a potassium-tellurite ethidium and proflavin transporter YP_002397572.1 1567022 D 585397 CDS YP_002397573.1 218689361 7141532 1568011..1568604 1 NC_011745.1 with TehA confers resistance to tellurite; tellurite resistance protein TehB 1568604 tehB 7141532 tehB Escherichia coli ED1a tellurite resistance protein TehB YP_002397573.1 1568011 D 585397 CDS YP_002397574.1 218689362 7141533 1568907..1569575 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; putative lipoprotein 1569575 ydcL 7141533 ydcL Escherichia coli ED1a putative lipoprotein YP_002397574.1 1568907 D 585397 CDS YP_002397575.1 218689363 7139227 complement(1569610..1570788) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1885518; Product type pt : putative transporter; putative benzoate transporter 1570788 ydcO 7139227 ydcO Escherichia coli ED1a putative benzoate transporter YP_002397575.1 1569610 R 585397 CDS YP_002397576.1 218689364 7139230 1570874..1571410 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1571410 ydcN 7139230 ydcN Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002397576.1 1570874 D 585397 CDS YP_002397577.1 218689365 7139229 1571483..1573444 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative peptidase 1573444 ydcP 7139229 ydcP Escherichia coli ED1a putative peptidase YP_002397577.1 1571483 D 585397 CDS YP_002397578.1 218689366 7139231 complement(1573536..1573766) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1573766 yncJ 7139231 yncJ Escherichia coli ED1a hypothetical protein YP_002397578.1 1573536 R 585397 CDS YP_002397579.1 218689367 7139232 1574260..1575666 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15223311; Product type pr : putative regulator; putative DNA-binding transcriptional regulator fused with a domain with PLP-binding motif 1575666 ydcR 7139232 ydcR Escherichia coli ED1a putative DNA-binding transcriptional regulator fused with a domain with PLP-binding motif YP_002397579.1 1574260 D 585397 CDS YP_002397580.1 218689368 7139233 1575911..1577056 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11683869; Product type pt : putative transporter; putative spermidine/putrescine ABC transporter subunit periplasmic-binding protein transporter 1577056 ydcS 7139233 ydcS Escherichia coli ED1a putative spermidine/putrescine ABC transporter subunit periplasmic-binding protein transporter YP_002397580.1 1575911 D 585397 CDS YP_002397581.1 218689369 7139234 1577074..1578087 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative spermidine/putrescine ABC transporter ATP-binding protein 1578087 ydcT 7139234 ydcT Escherichia coli ED1a putative spermidine/putrescine ABC transporter ATP-binding protein YP_002397581.1 1577074 D 585397 CDS YP_002397582.1 218689370 7139235 1578088..1579029 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative spermidine/putrescine ABC transporter permease 1579029 ydcU 7139235 ydcU Escherichia coli ED1a putative spermidine/putrescine ABC transporter permease YP_002397582.1 1578088 D 585397 CDS YP_002397583.1 218689371 7139236 1579019..1579813 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative spermidine/putrescine ABC transporter permease 1579813 ydcV 7139236 ydcV Escherichia coli ED1a putative spermidine/putrescine ABC transporter permease YP_002397583.1 1579019 D 585397 CDS YP_002397584.1 218689372 7139237 1579835..1581259 1 NC_011745.1 catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation; gamma-aminobutyraldehyde dehydrogenase 1581259 ydcW 7139237 ydcW Escherichia coli ED1a gamma-aminobutyraldehyde dehydrogenase YP_002397584.1 1579835 D 585397 CDS YP_002397585.1 218689373 7139238 1581573..1581821 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1581821 ydcX 7139238 ydcX Escherichia coli ED1a hypothetical protein YP_002397585.1 1581573 D 585397 CDS YP_002397586.1 218689374 7139239 1581907..1582140 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1582140 ydcY 7139239 ydcY Escherichia coli ED1a hypothetical protein YP_002397586.1 1581907 D 585397 CDS YP_002397587.1 218689375 7139240 complement(1582141..1582590) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1582590 ydcZ 7139240 ydcZ Escherichia coli ED1a hypothetical protein YP_002397587.1 1582141 R 585397 CDS YP_002397588.1 218689376 7139241 complement(1582587..1583105) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acyl-CoA N-acyltransferase domain-containing acyltransferase 1583105 yncA 7139241 yncA Escherichia coli ED1a putative acyl-CoA N-acyltransferase domain-containing acyltransferase YP_002397588.1 1582587 R 585397 CDS YP_002397589.1 218689377 7140993 1583314..1583550 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1583550 7140993 ECED1_1603 Escherichia coli ED1a hypothetical protein YP_002397589.1 1583314 D 585397 CDS YP_002397590.1 218689378 7142784 complement(1583588..1585690) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative iron outer membrane receptor 1585690 yncD 7142784 yncD Escherichia coli ED1a putative iron outer membrane receptor YP_002397590.1 1583588 R 585397 CDS YP_002397591.1 218689379 7140994 1585932..1586993 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1586993 yncE 7140994 yncE Escherichia coli ED1a hypothetical protein YP_002397591.1 1585932 D 585397 CDS YP_002397592.1 218689380 7140995 complement(1587106..1588605) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 76005443; Product type t : transporter; L-asparagine transporter 1588605 ansP 7140995 ansP Escherichia coli ED1a L-asparagine transporter YP_002397592.1 1587106 R 585397 CDS YP_002397593.1 218689381 7140998 1590333..1592738 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative VgrG/E protein associated with Rhs elements 1592738 7140998 ECED1_1610 Escherichia coli ED1a putative VgrG/E protein associated with Rhs elements YP_002397593.1 1590333 D 585397 CDS YP_002397594.1 218689382 7142785 1592692..1593519 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative zinc-dependent metallopeptidase 1593519 7142785 ECED1_1611 Escherichia coli ED1a putative zinc-dependent metallopeptidase YP_002397594.1 1592692 D 585397 CDS YP_002397595.1 218689383 7142786 1593543..1594328 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1594328 7142786 ECED1_1612 Escherichia coli ED1a hypothetical protein YP_002397595.1 1593543 D 585397 CDS YP_002397596.1 218689384 7142024 1594662..1594877 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1594877 7142024 ECED1_1614 Escherichia coli ED1a hypothetical protein YP_002397596.1 1594662 D 585397 CDS YP_002397597.1 218689385 7142788 complement(1595194..1595763) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1595763 yddH 7142788 yddH Escherichia coli ED1a hypothetical protein YP_002397597.1 1595194 R 585397 CDS YP_002397598.1 218689386 7139244 1595938..1596783 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20267568; Product type e : enzyme; N-hydroxyarylamine O-acetyltransferase 1596783 nhoA 7139244 nhoA Escherichia coli ED1a N-hydroxyarylamine O-acetyltransferase YP_002397598.1 1595938 D 585397 CDS YP_002397599.1 218689387 7140385 complement(1596879..1597772) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14611652, 15103639, 2233673; hypothetical protein 1597772 yddE 7140385 yddE Escherichia coli ED1a hypothetical protein YP_002397599.1 1596879 R 585397 CDS YP_002397600.1 218689388 7139242 complement(1597852..1598532) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91042410; Product type e : enzyme; nitrate reductase 2 (NRZ) subunit gamma 1598532 narV 7139242 narV Escherichia coli ED1a nitrate reductase 2 (NRZ) subunit gamma YP_002397600.1 1597852 R 585397 CDS YP_002397601.1 218689389 7140366 complement(1598529..1599224) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91042410, 92186712; Product type f : factor; nitrate reductase 2 (NRZ) subunit delta 1599224 narW 7140366 narW Escherichia coli ED1a nitrate reductase 2 (NRZ) subunit delta YP_002397601.1 1598529 R 585397 CDS YP_002397602.1 218689390 7140367 complement(1599224..1600768) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91042410; Product type c : carrier; nitrate reductase 2 (NRZ) subunit beta 1600768 narY 7140367 narY Escherichia coli ED1a nitrate reductase 2 (NRZ) subunit beta YP_002397602.1 1599224 R 585397 CDS YP_002397603.1 218689391 7140369 complement(1600765..1604505) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91042410; Product type e : enzyme; nitrate reductase 2 (NRZ) subunit alpha 1604505 narZ 7140369 narZ Escherichia coli ED1a nitrate reductase 2 (NRZ) subunit alpha YP_002397603.1 1600765 R 585397 CDS YP_002397604.1 218689392 7140370 complement(1604600..1605988) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95266795, 2233673; Product type t : transporter; nitrate/nitrite transporter 1605988 narU 7140370 narU Escherichia coli ED1a nitrate/nitrite transporter YP_002397604.1 1604600 R 585397 CDS YP_002397605.1 218689393 7140365 complement(1606261..1607085) 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12410826; Product type t : transporter; hypothetical protein 1607085 yddG 7140365 yddG Escherichia coli ED1a hypothetical protein YP_002397605.1 1606261 R 585397 CDS YP_002397606.1 218689394 7139243 1607374..1610421 1 NC_011745.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; formate dehydrogenase-N subunit alpha, nitrate-inducible 1610421 fdnG 7139243 fdnG Escherichia coli ED1a formate dehydrogenase-N subunit alpha, nitrate-inducible YP_002397606.1 1607374 D 585397 CDS YP_002397607.1 218689395 7144139 1610434..1611318 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 76005553, 90375017, 92332427, 11884747, 1834669; Product type c : carrier; formate dehydrogenase-N, Fe-S subunit beta, nitrate-inducible 1611318 fdnH 7144139 fdnH Escherichia coli ED1a formate dehydrogenase-N, Fe-S subunit beta, nitrate-inducible YP_002397607.1 1610434 D 585397 CDS YP_002397608.1 218689396 7144140 1611311..1611964 1 NC_011745.1 nitrate-inducible, cytochrome b556(fdn) component of formate dehydrogenase; formate dehydrogenase-N subunit gamma 1611964 fdnI 7144140 fdnI Escherichia coli ED1a formate dehydrogenase-N subunit gamma YP_002397608.1 1611311 D 585397 CDS YP_002397609.1 218689397 7139245 complement(1612473..1612751) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative plasmid maintenance system killer protein 1612751 7139245 ECED1_1630 Escherichia coli ED1a putative plasmid maintenance system killer protein YP_002397609.1 1612473 R 585397 CDS YP_002397610.1 218689398 7142789 complement(1612937..1613947) 1 NC_011745.1 similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase 1613947 adhP 7142789 adhP Escherichia coli ED1a alcohol dehydrogenase YP_002397610.1 1612937 R 585397 CDS YP_002397611.1 218689399 7143661 complement(1614081..1615778) 1 NC_011745.1 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase 1615778 sfcA 7143661 sfcA Escherichia coli ED1a malate dehydrogenase YP_002397611.1 1614081 R 585397 CDS YP_002397612.1 218689400 7141403 complement(1616174..1616389) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10498711, 13129944; Product type f : factor; biofilm-dependent modulation protein 1616389 bdm 7141403 bdm Escherichia coli ED1a biofilm-dependent modulation protein YP_002397612.1 1616174 R 585397 CDS YP_002397613.1 218689401 7140442 1616734..1617165 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14512736, 91350191, 9298646; Product type m : membrane component; osmotically inducible, stress-inducible membrane protein 1617165 osmC 7140442 osmC Escherichia coli ED1a osmotically inducible, stress-inducible membrane protein YP_002397613.1 1616734 D 585397 CDS YP_002397614.1 218689402 7139988 complement(1617355..1619754) 1 NC_011745.1 heme-regulated phosphodiesterase with phosphodiesterase activity with cAMP but not with cGMP, bis(p-nitrophenyl) phosphate or p-nitrophenyl phosphate; cAMP phosphodiesterase 1619754 dos 7139988 dos Escherichia coli ED1a cAMP phosphodiesterase YP_002397614.1 1617355 R 585397 CDS YP_002397615.1 218689403 7139246 complement(1620321..1621640) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10960106; Product type lp : lipoprotein; putative lipoprotein 1621640 yddW 7139246 yddW Escherichia coli ED1a putative lipoprotein YP_002397615.1 1620321 R 585397 CDS YP_002397616.1 218689404 7139247 complement(1621771..1623306) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15795232, 15489450; Product type t : transporter; glutamate:gamma-aminobutyric acid antiporter 1623306 gadC 7139247 gadC Escherichia coli ED1a glutamate:gamma-aminobutyric acid antiporter YP_002397616.1 1621771 R 585397 CDS YP_002397617.1 218689405 7143143 complement(1623462..1624862) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12912902, 92155241, 92394884, 99406302, 8455549; Product type e : enzyme; glutamate decarboxylase B, PLP-dependent 1624862 gadB 7143143 gadB Escherichia coli ED1a glutamate decarboxylase B, PLP-dependent YP_002397617.1 1623462 R 585397 CDS YP_002397618.1 218689406 7139113 complement(1626487..1627644) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pr : putative regulator; hypothetical protein 1627644 ydeM 7139113 ydeM Escherichia coli ED1a hypothetical protein YP_002397618.1 1626487 R 585397 CDS YP_002397619.1 218689407 7139251 complement(1627696..1629378) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sulfatase 1629378 ydeN 7139251 ydeN Escherichia coli ED1a putative sulfatase YP_002397619.1 1627696 R 585397 CDS YP_002397620.1 218689408 7139252 complement(1629780..1630541) 1 NC_011745.1 regulates the cellular response to acid resistance; transcriptional regulator YdeO 1630541 ydeO 7139252 ydeO Escherichia coli ED1a transcriptional regulator YdeO YP_002397620.1 1629780 R 585397 CDS YP_002397621.1 218689409 7139253 complement(1630617..1630850) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1630850 7139253 ECED1_1644 Escherichia coli ED1a hypothetical protein YP_002397621.1 1630617 R 585397 CDS YP_002397622.1 218689410 7142790 complement(1631062..1633341) 1 NC_011745.1 in Escherichia coli it may be involved in repression of type III secretion system (TTSS) genes of the host cell; involved with increased resistance to low pH; member of the prokaryotic molybdopterin-containing oxidoreductase family; putative oxidoreductase 1633341 ydeP 7142790 ydeP Escherichia coli ED1a putative oxidoreductase YP_002397622.1 1631062 R 585397 CDS YP_002397623.1 218689411 7139255 complement(1634039..1634887) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1634887 ydeT 7139255 ydeT Escherichia coli ED1a hypothetical protein YP_002397623.1 1634039 R 585397 CDS YP_002397624.1 218689412 7139256 complement(1634890..1635177) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1635177 7139256 ECED1_1648 Escherichia coli ED1a hypothetical protein YP_002397624.1 1634890 R 585397 CDS YP_002397625.1 218689413 7142791 complement(1635538..1636860) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91358364, 94292428, 15576765; Product type r : regulator; regulator with hipB 1636860 hipA 7142791 hipA Escherichia coli ED1a regulator with hipB YP_002397625.1 1635538 R 585397 CDS YP_002397626.1 218689414 7139885 complement(1636860..1637126) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91358364, 94292428, 15576765, 8021189; Product type r : regulator; DNA-binding transcriptional regulator HipB 1637126 hipB 7139885 hipB Escherichia coli ED1a DNA-binding transcriptional regulator HipB YP_002397626.1 1636860 R 585397 CDS YP_002397627.1 218689415 7141001 complement(1638417..1639904) 1 NC_011745.1 catalyzes the formation of D-tagaturonate from D-altronate; altronate oxidoreductase 1639904 uxaB 7141001 uxaB Escherichia coli ED1a altronate oxidoreductase YP_002397627.1 1638417 R 585397 CDS YP_002397628.1 218689416 7139156 complement(1639968..1641356) 1 NC_011745.1 in Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase; putative succinate semialdehyde dehydrogenase 1641356 yneI 7139156 yneI Escherichia coli ED1a putative succinate semialdehyde dehydrogenase YP_002397628.1 1639968 R 585397 CDS YP_002397629.1 218689417 7141002 1641457..1642338 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1642338 yneJ 7141002 yneJ Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002397629.1 1641457 D 585397 CDS YP_002397630.1 218689418 7141003 1642677..1643867 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10094697, 99369894, 8383113, 10438792; Product type t : transporter; sugar efflux transporter 1643867 ydeA 7141003 ydeA Escherichia coli ED1a sugar efflux transporter YP_002397630.1 1642677 D 585397 CDS YP_002397631.1 218689419 7139248 complement(1643892..1644557) 1 NC_011745.1 protein involved in resistance to different drugs (tetracycline, chloramphenicol, beta-lactams, and quinolones); part of the multiple antibiotic resistance (mar) locus, which is composed by the genes marC and marRAB; unknown function; multiple drug resistance protein MarC 1644557 marC 7139248 marC Escherichia coli ED1a multiple drug resistance protein MarC YP_002397631.1 1643892 R 585397 CDS YP_002397632.1 218689420 7142214 1644769..1645203 1 NC_011745.1 Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes; DNA-binding transcriptional repressor MarR 1645203 marR 7142214 marR Escherichia coli ED1a DNA-binding transcriptional repressor MarR YP_002397632.1 1644769 D 585397 CDS YP_002397633.1 218689421 7142215 1645224..1645607 1 NC_011745.1 transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype; also activates sodA, zwf and micF; DNA-binding transcriptional activator MarA 1645607 marA 7142215 marA Escherichia coli ED1a DNA-binding transcriptional activator MarA YP_002397633.1 1645224 D 585397 CDS YP_002397634.1 218689422 7142212 1645639..1645857 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8383113; hypothetical protein 1645857 marB 7142212 marB Escherichia coli ED1a hypothetical protein YP_002397634.1 1645639 D 585397 CDS YP_002397635.1 218689423 7142213 complement(1645914..1647383) 1 NC_011745.1 converts 6-phospho-beta-D-glucosyl-(1,4)-D-glucose to glucose and glucose 6-phosphate; required for cellobiose uptake and metabolism; 6-phospho-beta-glucosidase 1647383 celA 7142213 celA Escherichia coli ED1a 6-phospho-beta-glucosidase YP_002397635.1 1645914 R 585397 CDS YP_002397636.1 218689424 7142793 complement(1647837..1648736) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20305052; Product type t : transporter; O-acetylserine/cysteine export protein 1648736 eamA 7142793 eamA Escherichia coli ED1a O-acetylserine/cysteine export protein YP_002397636.1 1647837 R 585397 CDS YP_002397637.1 218689425 7139763 1648931..1650118 1 NC_011745.1 YdeF; uncharacterized member of the major facilitator superfamily (MFS) of transporters; putative MFS-type transporter YdeE 1650118 ydeE 7139763 ydeE Escherichia coli ED1a putative MFS-type transporter YdeE YP_002397637.1 1648931 D 585397 CDS YP_002397638.1 218689426 7139249 complement(1650560..1651450) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1651450 ydeH 7139249 ydeH Escherichia coli ED1a hypothetical protein YP_002397638.1 1650560 R 585397 CDS YP_002397639.1 218689427 7139250 complement(1651957..1654002) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 216006, 8226676; Product type e : enzyme; dipeptidyl carboxypeptidase II 1654002 dcp 7139250 dcp Escherichia coli ED1a dipeptidyl carboxypeptidase II YP_002397639.1 1651957 R 585397 CDS YP_002397640.1 218689428 7143070 1654139..1654885 1 NC_011745.1 NADP(+)-dependent; catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine; 3-hydroxy acid dehydrogenase 1654885 ydfG 7143070 ydfG Escherichia coli ED1a 3-hydroxy acid dehydrogenase YP_002397640.1 1654139 D 585397 CDS YP_002397641.1 218689429 7139258 1654974..1655660 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1655660 ydfH 7139258 ydfH Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002397641.1 1654974 D 585397 CDS YP_002397642.1 218689430 7139259 1655837..1656040 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12084818; Product type pc : putative carrier; putative selenium carrying protein 1656040 ydfZ 7139259 ydfZ Escherichia coli ED1a putative selenium carrying protein YP_002397642.1 1655837 D 585397 CDS YP_002397643.1 218689431 7139272 complement(1656076..1657536) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative mannonate dehydrogenase 1657536 ydfI 7139272 ydfI Escherichia coli ED1a putative mannonate dehydrogenase YP_002397643.1 1656076 R 585397 CDS YP_002397644.1 218689432 7139261 complement(1658161..1658979) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS600 1658979 7139261 ECED1_1672 Escherichia coli ED1a transposase ORF B, IS600 YP_002397644.1 1658161 R 585397 CDS YP_002397645.1 218689433 7142794 complement(1659015..1659317) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS600 1659317 insM 7142794 insM Escherichia coli ED1a transposase ORF A, IS600 YP_002397645.1 1659015 R 585397 CDS YP_002397646.1 218689434 7139262 1660202..1660546 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative damage-inducible protein from phage origin (dinI-like) 1660546 7139262 ECED1_1675 Escherichia coli ED1a putative damage-inducible protein from phage origin (dinI-like) YP_002397646.1 1660202 D 585397 CDS YP_002397647.1 218689435 7142795 complement(1660913..1664938) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10722621, 17220264, 9194704, 9743528; Product type e : enzyme; peptidase S6, IgA endopeptidase from phage origin 1664938 eaaA 7142795 eaaA Escherichia coli ED1a peptidase S6, IgA endopeptidase from phage origin YP_002397647.1 1660913 R 585397 CDS YP_002397648.1 218689436 7139760 complement(1665212..1665682) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10722621; hypothetical protein 1665682 7139760 ECED1_1677 Escherichia coli ED1a hypothetical protein YP_002397648.1 1665212 R 585397 CDS YP_002397649.1 218689437 7142796 complement(1665770..1666954) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 16988252, 10722621; Product type f : factor; Immunoglobulin-binding protein from phage origin 1666954 eibA 7142796 eibA Escherichia coli ED1a Immunoglobulin-binding protein from phage origin YP_002397649.1 1665770 R 585397 CDS YP_002397650.1 218689438 7139778 complement(1667636..1668214) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1668214 7139778 ECED1_1679 Escherichia coli ED1a hypothetical protein YP_002397650.1 1667636 R 585397 CDS YP_002397651.1 218689439 7142797 complement(1668235..1669716) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative tail fiber protein from prophage 1669716 7142797 ECED1_1681 Escherichia coli ED1a putative tail fiber protein from prophage YP_002397651.1 1668235 R 585397 CDS YP_002397652.1 218689440 7142798 complement(1669901..1673431) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Host specificity protein J (tail component) from prophage 1673431 J 7142798 J Escherichia coli ED1a Host specificity protein J (tail component) from prophage YP_002397652.1 1669901 R 585397 CDS YP_002397653.1 218689441 7142480 complement(1673671..1674351) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail assembly protein I 1674351 7142480 ECED1_1683 Escherichia coli ED1a tail assembly protein I YP_002397653.1 1673671 R 585397 CDS YP_002397654.1 218689442 7142799 complement(1674249..1674986) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail fiber component K 1674986 7142799 ECED1_1684 Escherichia coli ED1a tail fiber component K YP_002397654.1 1674249 R 585397 CDS YP_002397655.1 218689443 7142800 complement(1675041..1675955) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type f : factor; putative antirepressor protein from phage origin 1675955 7142800 ECED1_1685 Escherichia coli ED1a putative antirepressor protein from phage origin YP_002397655.1 1675041 R 585397 CDS YP_002397656.1 218689444 7142802 1676245..1676517 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7999761, 10426954; Product type pr : putative regulator; putative regulatory protein (mnt like) 1676517 7142802 ECED1_1687 Escherichia coli ED1a putative regulatory protein (mnt like) YP_002397656.1 1676245 D 585397 CDS YP_002397657.1 218689445 7142803 1676517..1677053 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative Clp protease 1677053 7142803 ECED1_1688 Escherichia coli ED1a putative Clp protease YP_002397657.1 1676517 D 585397 CDS YP_002397658.1 218689446 7142804 complement(1677110..1677862) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein L 1677862 7142804 ECED1_1689 Escherichia coli ED1a minor tail protein L YP_002397658.1 1677110 R 585397 CDS YP_002397659.1 218689447 7142805 complement(1678005..1679168) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; outer membrane porin protein from phage origin 1679168 7142805 ECED1_1690 Escherichia coli ED1a outer membrane porin protein from phage origin YP_002397659.1 1678005 R 585397 CDS YP_002397660.1 218689448 7142806 complement(1679375..1679716) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11686382, 11282477, 9562894, 8878031; Product type f : factor; minor tail protein M 1679716 7142806 ECED1_1691 Escherichia coli ED1a minor tail protein M YP_002397660.1 1679375 R 585397 CDS YP_002397661.1 218689449 7142807 complement(1679709..1682951) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; tail component measure protein in prophage 1682951 7142807 ECED1_1692 Escherichia coli ED1a tail component measure protein in prophage YP_002397661.1 1679709 R 585397 CDS YP_002397662.1 218689450 7142808 complement(1683015..1683428) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1683428 7142808 ECED1_1693 Escherichia coli ED1a hypothetical protein YP_002397662.1 1683015 R 585397 CDS YP_002397663.1 218689451 7142809 complement(1683492..1683773) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1683773 7142809 ECED1_1694 Escherichia coli ED1a hypothetical protein YP_002397663.1 1683492 R 585397 CDS YP_002397664.1 218689452 7142810 complement(1683797..1684219) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative tail assembly protein in prophage 1684219 7142810 ECED1_1695 Escherichia coli ED1a putative tail assembly protein in prophage YP_002397664.1 1683797 R 585397 CDS YP_002397665.1 218689453 7142811 complement(1684186..1684902) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative major tail subunit in prophage 1684902 7142811 ECED1_1696 Escherichia coli ED1a putative major tail subunit in prophage YP_002397665.1 1684186 R 585397 CDS YP_002397666.1 218689454 7142812 complement(1684969..1685313) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1685313 7142812 ECED1_1697 Escherichia coli ED1a hypothetical protein YP_002397666.1 1684969 R 585397 CDS YP_002397667.1 218689455 7142813 complement(1685310..1685756) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative structural component in prophage 1685756 7142813 ECED1_1698 Escherichia coli ED1a putative structural component in prophage YP_002397667.1 1685310 R 585397 CDS YP_002397668.1 218689456 7142814 complement(1685753..1686103) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative head-tail adaptor in prophage 1686103 7142814 ECED1_1699 Escherichia coli ED1a putative head-tail adaptor in prophage YP_002397668.1 1685753 R 585397 CDS YP_002397669.1 218689457 7142815 complement(1686113..1686439) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1686439 7142815 ECED1_1700 Escherichia coli ED1a hypothetical protein YP_002397669.1 1686113 R 585397 CDS YP_002397670.1 218689458 7142823 complement(1686436..1687659) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1687659 7142823 ECED1_1701 Escherichia coli ED1a hypothetical protein YP_002397670.1 1686436 R 585397 CDS YP_002397671.1 218689459 7142824 complement(1687656..1689020) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type s : structure; phage portal protein 1689020 7142824 ECED1_1702 Escherichia coli ED1a phage portal protein YP_002397671.1 1687656 R 585397 CDS YP_002397672.1 218689460 7142825 complement(1688966..1689187) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1689187 7142825 ECED1_1703 Escherichia coli ED1a hypothetical protein YP_002397672.1 1688966 R 585397 CDS YP_002397673.1 218689461 7142194 complement(1689232..1691169) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative major head protein/prohead protease in prophage 1691169 7142194 ECED1_1704 Escherichia coli ED1a putative major head protein/prohead protease in prophage YP_002397673.1 1689232 R 585397 CDS YP_002397674.1 218689462 7143440 complement(1691233..1692894) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative large subunit terminase in prophage 1692894 7143440 ECED1_1705 Escherichia coli ED1a putative large subunit terminase in prophage YP_002397674.1 1691233 R 585397 CDS YP_002397675.1 218689463 7143441 complement(1692891..1693454) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative terminase small subunit in prophage 1693454 7143441 ECED1_1706 Escherichia coli ED1a putative terminase small subunit in prophage YP_002397675.1 1692891 R 585397 CDS YP_002397676.1 218689464 7143442 complement(1693744..1694109) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative endonuclease from phage origin 1694109 7143442 ECED1_1707 Escherichia coli ED1a putative endonuclease from phage origin YP_002397676.1 1693744 R 585397 CDS YP_002397677.1 218689465 7143443 1694091..1694351 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1694351 7143443 ECED1_1708 Escherichia coli ED1a hypothetical protein YP_002397677.1 1694091 D 585397 CDS YP_002397678.1 218689466 7143444 complement(1694483..1694824) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative tonB-like membrane protein from phage origin 1694824 7143444 ECED1_1709 Escherichia coli ED1a putative tonB-like membrane protein from phage origin YP_002397678.1 1694483 R 585397 CDS YP_002397679.1 218689467 7143445 complement(1694745..1695098) 1 NC_011745.1 Evidence 6 : Doubtful CDS; Product type h : extrachromosomal origin; hypothetical protein 1695098 7143445 ECED1_1710 Escherichia coli ED1a hypothetical protein YP_002397679.1 1694745 R 585397 CDS YP_002397680.1 218689468 7143446 complement(1695243..1695500) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1695500 7143446 ECED1_1711 Escherichia coli ED1a hypothetical protein YP_002397680.1 1695243 R 585397 CDS YP_002397681.1 218689469 7143447 complement(1695497..1696063) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1696063 7143447 ECED1_1712 Escherichia coli ED1a hypothetical protein YP_002397681.1 1695497 R 585397 CDS YP_002397682.1 218689470 7143448 complement(1696193..1696522) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1696522 7143448 ECED1_1713 Escherichia coli ED1a hypothetical protein YP_002397682.1 1696193 R 585397 CDS YP_002397683.1 218689471 7143449 complement(1696497..1696727) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1696727 7143449 ECED1_1714 Escherichia coli ED1a hypothetical protein YP_002397683.1 1696497 R 585397 CDS YP_002397684.1 218689472 7143450 complement(1696869..1697420) 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Endopeptidase (Lysis protein) from bacteriophage origin 1697420 rz 7143450 rz Escherichia coli ED1a Endopeptidase (Lysis protein) from bacteriophage origin YP_002397684.1 1696869 R 585397 CDS YP_002397685.1 218689473 7141359 complement(1697555..1697872) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1697872 7141359 ECED1_1718 Escherichia coli ED1a hypothetical protein YP_002397685.1 1697555 R 585397 CDS YP_002397686.1 218689474 7143451 complement(1697781..1698476) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative antirepressor in prophage 1698476 7143451 ECED1_1719 Escherichia coli ED1a putative antirepressor in prophage YP_002397686.1 1697781 R 585397 CDS YP_002397687.1 218689475 7143452 complement(1698750..1699283) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-associated lysozyme; Qin prophage 1699283 ydfQ 7143452 ydfQ Escherichia coli ED1a putative membrane-associated lysozyme; Qin prophage YP_002397687.1 1698750 R 585397 CDS YP_002397688.1 218689476 7139266 complement(1699603..1700112) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1700112 7139266 ECED1_1721 Escherichia coli ED1a hypothetical protein YP_002397688.1 1699603 R 585397 CDS YP_002397689.1 218689477 7143453 complement(1700150..1700332) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage lysis protein S 1700332 essD 7143453 essD Escherichia coli ED1a putative phage lysis protein S YP_002397689.1 1700150 R 585397 CDS YP_002397690.1 218689478 7139813 complement(1700408..1700872) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1700872 7139813 ECED1_1723 Escherichia coli ED1a hypothetical protein YP_002397690.1 1700408 R 585397 CDS YP_002397691.1 218689479 7143454 complement(1700931..1701104) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1701104 7143454 ECED1_1724 Escherichia coli ED1a hypothetical protein YP_002397691.1 1700931 R 585397 CDS YP_002397692.1 218689480 7143455 complement(1701058..1703046) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1703046 7143455 ECED1_1725 Escherichia coli ED1a hypothetical protein YP_002397692.1 1701058 R 585397 CDS YP_002397693.1 218689481 7143456 complement(1703573..1704160) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1704160 7143456 ECED1_1726 Escherichia coli ED1a hypothetical protein YP_002397693.1 1703573 R 585397 CDS YP_002397694.1 218689482 7143457 complement(1704102..1704422) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1704422 7143457 ECED1_1727 Escherichia coli ED1a hypothetical protein YP_002397694.1 1704102 R 585397 CDS YP_002397695.1 218689483 7143458 complement(1704742..1705431) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 3624233; Product type r : regulator; antitermination protein Q 1705431 7143458 ECED1_1728 Escherichia coli ED1a antitermination protein Q YP_002397695.1 1704742 R 585397 CDS YP_002397696.1 218689484 7143459 complement(1705422..1705781) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative crossover junction endodeoxyribonuclease RusA 1705781 7143459 ECED1_1729 Escherichia coli ED1a putative crossover junction endodeoxyribonuclease RusA YP_002397696.1 1705422 R 585397 CDS YP_002397697.1 218689485 7143460 complement(1705794..1706843) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1706843 ydfU 7143460 ydfU Escherichia coli ED1a hypothetical protein YP_002397697.1 1705794 R 585397 CDS YP_002397698.1 218689486 7139271 complement(1707683..1708369) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1708369 7139271 ECED1_1731 Escherichia coli ED1a hypothetical protein YP_002397698.1 1707683 R 585397 CDS YP_002397699.1 218689487 7143461 complement(1708523..1708933) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1708933 7143461 ECED1_1733 Escherichia coli ED1a hypothetical protein YP_002397699.1 1708523 R 585397 CDS YP_002397700.1 218689488 7143462 complement(1708934..1709677) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1709677 7143462 ECED1_1735 Escherichia coli ED1a hypothetical protein YP_002397700.1 1708934 R 585397 CDS YP_002397701.1 218689489 7143463 complement(1709693..1710358) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative replication protein in prophage 1710358 7143463 ECED1_1736 Escherichia coli ED1a putative replication protein in prophage YP_002397701.1 1709693 R 585397 CDS YP_002397702.1 218689490 7143464 complement(1710147..1711193) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1711193 7143464 ECED1_1737 Escherichia coli ED1a hypothetical protein YP_002397702.1 1710147 R 585397 CDS YP_002397703.1 218689491 7143465 complement(1711256..1711681) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1711681 7143465 ECED1_1738 Escherichia coli ED1a hypothetical protein YP_002397703.1 1711256 R 585397 CDS YP_002397704.1 218689492 7143466 complement(1711665..1711946) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1711946 7143466 ECED1_1739 Escherichia coli ED1a hypothetical protein YP_002397704.1 1711665 R 585397 CDS YP_002397705.1 218689493 7143467 1712047..1712466 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1712466 7143467 ECED1_1740 Escherichia coli ED1a hypothetical protein YP_002397705.1 1712047 D 585397 CDS YP_002397706.1 218689494 7143468 1712539..1712883 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1712883 7143468 ECED1_1741 Escherichia coli ED1a hypothetical protein YP_002397706.1 1712539 D 585397 CDS YP_002397707.1 218689495 7143469 complement(1712982..1713428) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1713428 7143469 ECED1_1742 Escherichia coli ED1a hypothetical protein YP_002397707.1 1712982 R 585397 CDS YP_002397708.1 218689496 7143470 1714132..1714320 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 3041373; Product type h : extrachromosomal origin; Cell division inhibition protein dicB from bacteriophage origin 1714320 dicB 7143470 dicB Escherichia coli ED1a Cell division inhibition protein dicB from bacteriophage origin YP_002397708.1 1714132 D 585397 CDS YP_002397709.1 218689497 7143115 1714598..1716955 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2199308; Product type h : extrachromosomal origin; Exodeoxyribonuclease VIII from bacteriophage origin 1716955 7143115 ECED1_1744 Escherichia coli ED1a Exodeoxyribonuclease VIII from bacteriophage origin YP_002397709.1 1714598 D 585397 CDS YP_002397710.1 218689498 7143471 1716955..1717278 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative excisionase 1717278 7143471 ECED1_1745 Escherichia coli ED1a putative excisionase YP_002397710.1 1716955 D 585397 CDS YP_002397711.1 218689499 7143472 1717298..1718593 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative defective integrase; Qin prophage 1718593 intQ 7143472 intQ Escherichia coli ED1a putative defective integrase; Qin prophage YP_002397711.1 1717298 D 585397 CDS YP_002397712.1 218689500 7142443 complement(1718613..1718723) 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 1718723 ynfP 7142443 ynfP Escherichia coli ED1a hypothetical protein YP_002397712.1 1718613 R 585397 CDS YP_002397713.1 218689501 7141017 complement(1718781..1719800) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7545940; Product type pe : putative enzyme; putative dehydrogenase 1719800 rspB 7141017 rspB Escherichia coli ED1a putative dehydrogenase YP_002397713.1 1718781 R 585397 CDS YP_002397714.1 218689502 7140118 complement(1719812..1721026) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 93341455, 94310441; Product type pe : putative enzyme; putative enolase/dehydratase 1721026 rspA 7140118 rspA Escherichia coli ED1a putative enolase/dehydratase YP_002397714.1 1719812 R 585397 CDS YP_002397715.1 218689503 7140116 complement(1721233..1721559) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1721559 ynfA 7140116 ynfA Escherichia coli ED1a hypothetical protein YP_002397715.1 1721233 R 585397 CDS YP_002397716.1 218689504 7141004 1721694..1722035 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1722035 ynfB 7141004 ynfB Escherichia coli ED1a hypothetical protein YP_002397716.1 1721694 D 585397 CDS YP_002397717.1 218689505 7141005 1722070..1722630 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94357898; Product type e : enzyme; spermidine N1-acetyltransferase 1722630 speG 7141005 speG Escherichia coli ED1a spermidine N1-acetyltransferase YP_002397717.1 1722070 D 585397 CDS YP_002397718.1 218689506 7143829 complement(1722633..1723343) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1723343 ynfC 7143829 ynfC Escherichia coli ED1a hypothetical protein YP_002397718.1 1722633 R 585397 CDS YP_002397719.1 218689507 7141006 1723451..1723756 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9868784; hypothetical protein 1723756 ynfD 7141006 ynfD Escherichia coli ED1a hypothetical protein YP_002397719.1 1723451 D 585397 CDS YP_002397720.1 218689508 7141009 1726441..1728864 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14522592; Product type e : enzyme; oxidoreductase subunit 1728864 ynfF 7141009 ynfF Escherichia coli ED1a oxidoreductase subunit YP_002397720.1 1726441 D 585397 CDS YP_002397721.1 218689509 7141010 1728875..1729492 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14522592; Product type c : carrier; oxidoreductase, Fe-S subunit 1729492 ynfG 7141010 ynfG Escherichia coli ED1a oxidoreductase, Fe-S subunit YP_002397721.1 1728875 D 585397 CDS YP_002397722.1 218689510 7141011 1729494..1730348 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14522592; Product type m : membrane component; oxidoreductase, membrane subunit 1730348 ynfH 7141011 ynfH Escherichia coli ED1a oxidoreductase, membrane subunit YP_002397722.1 1729494 D 585397 CDS YP_002397723.1 218689511 7141012 1730391..1731005 1 NC_011745.1 binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane; twin-argninine leader-binding protein DmsD 1731005 dmsD 7141012 dmsD Escherichia coli ED1a twin-argninine leader-binding protein DmsD YP_002397723.1 1730391 D 585397 CDS YP_002397724.1 218689512 7140501 1731200..1732456 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12384697; Product type pt : putative transporter; putative voltage-gated ClC-type chloride channel ClcB 1732456 clcB 7140501 clcB Escherichia coli ED1a putative voltage-gated ClC-type chloride channel ClcB YP_002397724.1 1731200 D 585397 CDS YP_002397725.1 218689513 7139369 complement(1732409..1733104) 1 NC_011745.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; putative dithiobiotin synthetase 1733104 ynfK 7139369 ynfK Escherichia coli ED1a putative dithiobiotin synthetase YP_002397725.1 1732409 R 585397 CDS YP_002397726.1 218689514 7141013 complement(1733229..1734449) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10318813, 20490366, 6989798, 99340206, 99395104, 99398866, 7766024; Product type r : regulator; DNA-binding transcriptional repressor 1734449 dgsA 7141013 dgsA Escherichia coli ED1a DNA-binding transcriptional repressor YP_002397726.1 1733229 R 585397 CDS YP_002397727.1 218689515 7143108 complement(1734584..1735477) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1735477 ynfL 7143108 ynfL Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002397727.1 1734584 R 585397 CDS YP_002397728.1 218689516 7141014 1735584..1736837 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter 1736837 ynfM 7141014 ynfM Escherichia coli ED1a putative MFS superfamily transporter YP_002397728.1 1735584 D 585397 CDS YP_002397729.1 218689517 7141015 1737262..1737570 1 NC_011745.1 required for growth and survival under moderately acid conditions; acid shock protein 1737570 asr 7141015 asr Escherichia coli ED1a acid shock protein YP_002397729.1 1737262 D 585397 CDS YP_002397730.1 218689518 7142652 1737846..1738667 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative exported metallopeptidase 1738667 ydgD 7142652 ydgD Escherichia coli ED1a putative exported metallopeptidase YP_002397730.1 1737846 D 585397 CDS YP_002397731.1 218689519 7139275 complement(1738706..1739035) 1 NC_011745.1 with MdtJ is involved in resistance to deoxycholate, nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtI 1739035 mdtI 7139275 mdtI Escherichia coli ED1a multidrug efflux system protein MdtI YP_002397731.1 1738706 R 585397 CDS YP_002397732.1 218689520 7142235 complement(1739022..1739387) 1 NC_011745.1 with MdtI is involved in resistance to deoxycholate , nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtJ 1739387 mdtJ 7142235 mdtJ Escherichia coli ED1a multidrug efflux system protein MdtJ YP_002397732.1 1739022 R 585397 CDS YP_002397733.1 218689521 7139276 complement(1740262..1740444) 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 1740444 7139276 ECED1_1771 Escherichia coli ED1a hypothetical protein YP_002397733.1 1740262 R 585397 CDS YP_002397734.1 218689522 7143473 complement(1740701..1740982) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1740982 7143473 ECED1_1772 Escherichia coli ED1a hypothetical protein YP_002397734.1 1740701 R 585397 CDS YP_002397735.1 218689523 7143474 complement(1740996..1742657) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage terminase large subunit 1742657 7143474 ECED1_1773 Escherichia coli ED1a putative phage terminase large subunit YP_002397735.1 1740996 R 585397 CDS YP_002397736.1 218689524 7143475 complement(1742641..1742997) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage terminase, small subunit 1742997 7143475 ECED1_1774 Escherichia coli ED1a putative phage terminase, small subunit YP_002397736.1 1742641 R 585397 CDS YP_002397737.1 218689525 7143476 complement(1743289..1743726) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; putative endonuclease 1743726 7143476 ECED1_1775 Escherichia coli ED1a putative endonuclease YP_002397737.1 1743289 R 585397 CDS YP_002397738.1 218689526 7143477 complement(1743726..1744022) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1744022 7143477 ECED1_1777 Escherichia coli ED1a hypothetical protein YP_002397738.1 1743726 R 585397 CDS YP_002397739.1 218689527 7143478 complement(1744354..1745565) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative head portal protein 1745565 7143478 ECED1_1778 Escherichia coli ED1a putative head portal protein YP_002397739.1 1744354 R 585397 CDS YP_002397740.1 218689528 7143479 complement(1745567..1746139) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative head maturation protease of prophage 1746139 7143479 ECED1_1779 Escherichia coli ED1a putative head maturation protease of prophage YP_002397740.1 1745567 R 585397 CDS YP_002397741.1 218689529 7143436 complement(1746179..1747384) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative capsid protein of prophage ( major head protein) 1747384 7143436 ECED1_1780 Escherichia coli ED1a putative capsid protein of prophage ( major head protein) YP_002397741.1 1746179 R 585397 CDS YP_002397742.1 218689530 7143437 complement(1747637..1747939) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1747939 7143437 ECED1_1781 Escherichia coli ED1a hypothetical protein YP_002397742.1 1747637 R 585397 CDS YP_002397743.1 218689531 7143438 complement(1748003..1748371) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8885267; Product type h : extrachromosomal origin; putative transcriptional activator (PerC family) from phage origin 1748371 7143438 ECED1_1783 Escherichia coli ED1a putative transcriptional activator (PerC family) from phage origin YP_002397743.1 1748003 R 585397 CDS YP_002397744.1 218689532 7140871 complement(1748262..1748672) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative single stranded DNA-binding protein of prophage 1748672 7140871 ECED1_1784 Escherichia coli ED1a putative single stranded DNA-binding protein of prophage YP_002397744.1 1748262 R 585397 CDS YP_002397745.1 218689533 7140872 complement(1748669..1748947) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1748947 7140872 ECED1_1785 Escherichia coli ED1a hypothetical protein YP_002397745.1 1748669 R 585397 CDS YP_002397746.1 218689534 7140873 complement(1749234..1750982) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; nucleic acid independent nucleoside triphosphatase; phage DNA primase 1750982 7140873 ECED1_1786 Escherichia coli ED1a nucleic acid independent nucleoside triphosphatase; phage DNA primase YP_002397746.1 1749234 R 585397 CDS YP_002397747.1 218689535 7140874 complement(1750979..1751278) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1751278 7140874 ECED1_1787 Escherichia coli ED1a hypothetical protein YP_002397747.1 1750979 R 585397 CDS YP_002397748.1 218689536 7140875 complement(1751284..1751547) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1751547 7140875 ECED1_1788 Escherichia coli ED1a hypothetical protein YP_002397748.1 1751284 R 585397 CDS YP_002397749.1 218689537 7140876 complement(1751516..1751707) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1751707 7140876 ECED1_1789 Escherichia coli ED1a hypothetical protein YP_002397749.1 1751516 R 585397 CDS YP_002397750.1 218689538 7140877 complement(1751707..1751892) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1751892 7140877 ECED1_1790 Escherichia coli ED1a hypothetical protein YP_002397750.1 1751707 R 585397 CDS YP_002397751.1 218689539 7140878 complement(1751885..1752391) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1752391 7140878 ECED1_1791 Escherichia coli ED1a hypothetical protein YP_002397751.1 1751885 R 585397 CDS YP_002397752.1 218689540 7140880 1752593..1753045 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1753045 7140880 ECED1_1793 Escherichia coli ED1a hypothetical protein YP_002397752.1 1752593 D 585397 CDS YP_002397753.1 218689541 7140881 1753103..1753330 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1753330 7140881 ECED1_1794 Escherichia coli ED1a hypothetical protein YP_002397753.1 1753103 D 585397 CDS YP_002397754.1 218689542 7140882 1753551..1753724 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1753724 7140882 ECED1_1795 Escherichia coli ED1a hypothetical protein YP_002397754.1 1753551 D 585397 CDS YP_002397755.1 218689543 7140883 1753767..1753955 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1753955 7140883 ECED1_1796 Escherichia coli ED1a hypothetical protein YP_002397755.1 1753767 D 585397 CDS YP_002397756.1 218689544 7140884 complement(1754225..1754413) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage regulatory protein 1754413 7140884 ECED1_1797 Escherichia coli ED1a putative phage regulatory protein YP_002397756.1 1754225 R 585397 CDS YP_002397757.1 218689545 7140885 complement(1754788..1756017) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; integrase of prophage 1756017 int 7140885 int Escherichia coli ED1a integrase of prophage YP_002397757.1 1754788 R 585397 CDS YP_002397758.1 218689546 7141175 complement(1755035..1755238) 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 1755238 7141175 ECED1_1799 Escherichia coli ED1a hypothetical protein YP_002397758.1 1755035 R 585397 CDS YP_002397759.1 218689547 7140886 1756215..1757099 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14727089; Product type pm : putative membrane component; hypothetical protein 1757099 ydgG 7140886 ydgG Escherichia coli ED1a hypothetical protein YP_002397759.1 1756215 D 585397 CDS YP_002397760.1 218689548 7139277 complement(1757124..1758512) 1 NC_011745.1 catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme; pyridine nucleotide transhydrogenase 1758512 pntB 7139277 pntB Escherichia coli ED1a pyridine nucleotide transhydrogenase YP_002397760.1 1757124 R 585397 CDS YP_002397761.1 218689549 7139079 complement(1758523..1760055) 1 NC_011745.1 forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm; NAD(P) transhydrogenase subunit alpha 1760055 pntA 7139079 pntA Escherichia coli ED1a NAD(P) transhydrogenase subunit alpha YP_002397761.1 1758523 R 585397 CDS YP_002397762.1 218689550 7139078 1760579..1761523 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1761523 ydgH 7139078 ydgH Escherichia coli ED1a hypothetical protein YP_002397762.1 1760579 D 585397 CDS YP_002397763.1 218689551 7139278 1761709..1763091 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1311296; Product type pt : putative transporter; putative arginine/ornithine antiporter transporter 1763091 ydgI 7139278 ydgI Escherichia coli ED1a putative arginine/ornithine antiporter transporter YP_002397763.1 1761709 D 585397 CDS YP_002397764.1 218689552 7139279 1763128..1763850 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14617668; Product type e : enzyme; short chain dehydrogenase 1763850 folM 7139279 folM Escherichia coli ED1a short chain dehydrogenase YP_002397764.1 1763128 D 585397 CDS YP_002397765.1 218689553 7142161 complement(1763847..1764182) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1764182 ydgC 7142161 ydgC Escherichia coli ED1a hypothetical protein YP_002397765.1 1763847 R 585397 CDS YP_002397766.1 218689554 7139274 1764302..1765030 1 NC_011745.1 response regulator in two-component regulatory system with RstB; DNA-binding transcriptional regulator RstA 1765030 rstA 7139274 rstA Escherichia coli ED1a DNA-binding transcriptional regulator RstA YP_002397766.1 1764302 D 585397 CDS YP_002397767.1 218689555 7140121 1765034..1766335 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93086426, 1495392, 1925016, 2646639; Product type r : regulator; sensor protein RstB 1766335 rstB 7140121 rstB Escherichia coli ED1a sensor protein RstB YP_002397767.1 1765034 D 585397 CDS YP_002397768.1 218689556 7140122 1766411..1767340 1 NC_011745.1 binds to DNA replication terminator sequences to prevent passage of replication forks; DNA replication terminus site-binding protein 1767340 tus 7140122 tus Escherichia coli ED1a DNA replication terminus site-binding protein YP_002397768.1 1766411 D 585397 CDS YP_002397769.1 218689557 7140844 complement(1767337..1768740) 1 NC_011745.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 1768740 fumC 7140844 fumC Escherichia coli ED1a fumarate hydratase YP_002397769.1 1767337 R 585397 CDS YP_002397770.1 218689558 7143133 complement(1768883..1770529) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88193096, 88268900, 92011457, 3005475, 6328431, 9298646; Product type e : enzyme; fumarate hydratase 1770529 fumA 7143133 fumA Escherichia coli ED1a fumarate hydratase YP_002397770.1 1768883 R 585397 CDS YP_002397771.1 218689559 7143131 1770728..1771903 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82100097, 6397402; Product type e : enzyme; mannose-6-phosphate isomerase 1771903 manA 7143131 manA Escherichia coli ED1a mannose-6-phosphate isomerase YP_002397771.1 1770728 D 585397 CDS YP_002397772.1 218689560 7142207 1772004..1773512 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1773512 ydgA 7142207 ydgA Escherichia coli ED1a hypothetical protein YP_002397772.1 1772004 D 585397 CDS YP_002397773.1 218689561 7139273 complement(1773557..1774822) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15774881; Product type t : transporter; putative outer membrane porin protein 1774822 uidC 7139273 uidC Escherichia coli ED1a putative outer membrane porin protein YP_002397773.1 1773557 R 585397 CDS YP_002397774.1 218689562 7138884 complement(1774861..1776234) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3534890; Product type t : transporter; glucuronide transporter 1776234 uidB 7138884 uidB Escherichia coli ED1a glucuronide transporter YP_002397774.1 1774861 R 585397 CDS YP_002397775.1 218689563 7138883 complement(1776231..1778042) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87041472, 88038341, 2103475, 8125312; Product type e : enzyme; beta-D-glucuronidase 1778042 uidA 7138883 uidA Escherichia coli ED1a beta-D-glucuronidase YP_002397775.1 1776231 R 585397 CDS YP_002397776.1 218689564 7138882 complement(1778430..1779020) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88038341, 2823062, 3934044, 11115104; Product type r : regulator; DNA-binding transcriptional repressor 1779020 uidR 7138882 uidR Escherichia coli ED1a DNA-binding transcriptional repressor YP_002397776.1 1778430 R 585397 CDS YP_002397777.1 218689565 7138885 complement(1779249..1780016) 1 NC_011745.1 Acts on the hydroxyl group at position 7 of the steroid frame; 7-alpha-hydroxysteroid dehydrogenase 1780016 hdhA 7138885 hdhA Escherichia coli ED1a 7-alpha-hydroxysteroid dehydrogenase YP_002397777.1 1779249 R 585397 CDS YP_002397778.1 218689566 7139863 complement(1780128..1781156) 1 NC_011745.1 regulates malXY which are involved in maltose-glucose transport; DNA-binding transcriptional repressor MalI 1781156 malI 7139863 malI Escherichia coli ED1a DNA-binding transcriptional repressor MalI YP_002397778.1 1780128 R 585397 CDS YP_002397779.1 218689567 7142197 1781331..1782923 1 NC_011745.1 phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS); catalyzes the phosphorylation of maltose and glucose concomitant with their translocation across the cell membrane; component IIB catalyzes the phosphorylation of the sugar molecule; IIC forms the translocation channel and contains the substrate specific binding site; bifunctional PTS system maltose and glucose-specific transporter subunits IICB 1782923 malX 7142197 malX Escherichia coli ED1a bifunctional PTS system maltose and glucose-specific transporter subunits IICB YP_002397779.1 1781331 D 585397 CDS YP_002397780.1 218689568 7142204 1782933..1784105 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20164451, 7665481, 91310596; Product type e : enzyme; bifunctional beta-cystathionase, PLP-dependent and regulator of maltose regulon 1784105 malY 7142204 malY Escherichia coli ED1a bifunctional beta-cystathionase, PLP-dependent and regulator of maltose regulon YP_002397780.1 1782933 D 585397 CDS YP_002397781.1 218689569 7142205 1784209..1785210 1 NC_011745.1 catalyzes the formation of inosine from adenosine; adenosine deaminase 1785210 add 7142205 add Escherichia coli ED1a adenosine deaminase YP_002397781.1 1784209 D 585397 CDS YP_002397782.1 218689570 7143658 complement(1785246..1786286) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 1786286 ydgJ 7143658 ydgJ Escherichia coli ED1a putative oxidoreductase YP_002397782.1 1785246 R 585397 CDS YP_002397783.1 218689571 7139280 1786454..1786654 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20392465, 10931331; Product type m : membrane component; beta-lactam resistance membrane protein 1786654 blr 7139280 blr Escherichia coli ED1a beta-lactam resistance membrane protein YP_002397783.1 1786454 D 585397 CDS YP_002397784.1 218689572 7140460 1786928..1787143 1 NC_011745.1 YdgT; in E. coli, when complexed with H-NS or StpA binds a 26 base-pair DNA sequence of oriC; seems to play a role in optimizing the activity of oriC; non-essential; Hha protein paralog; in an hha mutant background, cnu is overexpressed and can compensate hha-induced phenotypes; oriC-binding nucleoid-associated protein 1787143 ydgT 7140460 ydgT Escherichia coli ED1a oriC-binding nucleoid-associated protein YP_002397784.1 1786928 D 585397 CDS YP_002397785.1 218689573 7139283 1787229..1787669 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1787669 ydgK 7139283 ydgK Escherichia coli ED1a hypothetical protein YP_002397785.1 1787229 D 585397 CDS YP_002397786.1 218689574 7139281 1787746..1788327 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10411911, 10637328, 12773378; Product type pm : putative membrane component; Na(+)-translocating NADH-quinone reductase subunit E 1788327 rsxA 7139281 rsxA Escherichia coli ED1a Na(+)-translocating NADH-quinone reductase subunit E YP_002397786.1 1787746 D 585397 CDS YP_002397787.1 218689575 7140124 1788327..1788905 1 NC_011745.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfB 1788905 rsxB 7140124 rsxB Escherichia coli ED1a electron transport complex protein RnfB YP_002397787.1 1788327 D 585397 CDS YP_002397788.1 218689576 7140125 1788898..1791024 1 NC_011745.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfC 1791024 rsxC 7140125 rsxC Escherichia coli ED1a electron transport complex protein RnfC YP_002397788.1 1788898 D 585397 CDS YP_002397789.1 218689577 7140126 1791025..1792083 1 NC_011745.1 RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents; electron transport complex protein RnfD 1792083 rnfD 7140126 rnfD Escherichia coli ED1a electron transport complex protein RnfD YP_002397789.1 1791025 D 585397 CDS YP_002397790.1 218689578 7140127 1792087..1792707 1 NC_011745.1 part of membrane-bound complex hought to be involved in electron transport to nitrogen; electron transport complex protein RnfG 1792707 rsxG 7140127 rsxG Escherichia coli ED1a electron transport complex protein RnfG YP_002397790.1 1792087 D 585397 CDS YP_002397791.1 218689579 7140129 1792711..1793406 1 NC_011745.1 in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase; electron transport complex RsxE subunit 1793406 rsxE 7140129 rsxE Escherichia coli ED1a electron transport complex RsxE subunit YP_002397791.1 1792711 D 585397 CDS YP_002397792.1 218689580 7140128 1793406..1794041 1 NC_011745.1 DNA-(apurinic or apyrimidinic site) lyase; has apurinic or apyrimidinic endonuclease activity and DNA N-glycosylase activity; removed damaged DNA at cytosines, thymines and guanines; endonuclease III 1794041 nth 7140128 nth Escherichia coli ED1a endonuclease III YP_002397792.1 1793406 D 585397 CDS YP_002397793.1 218689581 7139936 1794652..1796154 1 NC_011745.1 mutations in this gene confer resistance to the toxic peptide alafosfalin in Salmonella typhimurium; member of proton-dependent oligopeptide transport (POT) system family; in Escherichia coli this gene is regulated by OmpR although not via osmoregulation; putative tripeptide transporter permease 1796154 tppB 7139936 tppB Escherichia coli ED1a putative tripeptide transporter permease YP_002397793.1 1794652 D 585397 CDS YP_002397794.1 218689582 7139282 1796260..1796865 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95096109, 2185038, 9680481; Product type e : enzyme; glutathionine S-transferase 1796865 gst 7139282 gst Escherichia coli ED1a glutathionine S-transferase YP_002397794.1 1796260 D 585397 CDS YP_002397795.1 218689583 7139842 complement(1796909..1797772) 1 NC_011745.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxamine kinase 1797772 pdxY 7139842 pdxY Escherichia coli ED1a pyridoxamine kinase YP_002397795.1 1796909 R 585397 CDS YP_002397796.1 218689584 7144057 complement(1797831..1799105) 1 NC_011745.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 1799105 tyrS 7144057 tyrS Escherichia coli ED1a tyrosyl-tRNA synthetase YP_002397796.1 1797831 R 585397 CDS YP_002397797.1 218689585 7140854 complement(1799234..1799890) 1 NC_011745.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase 1799890 pdxH 7140854 pdxH Escherichia coli ED1a pyridoxamine 5'-phosphate oxidase YP_002397797.1 1799234 R 585397 CDS YP_002397798.1 218689586 7144054 complement(1799949..1800278) 1 NC_011745.1 MliC; membrane-bound lysozyme inhibitor of c-type lysozyme; lysozyme inhibitor 1800278 ydhA 7144054 ydhA Escherichia coli ED1a lysozyme inhibitor YP_002397798.1 1799949 R 585397 CDS YP_002397799.1 218689587 7139284 complement(1800376..1801485) 1 NC_011745.1 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling; anhydro-N-acetylmuramic acid kinase 1801485 anmK 7139284 anmK Escherichia coli ED1a anhydro-N-acetylmuramic acid kinase YP_002397799.1 1800376 R 585397 CDS YP_002397800.1 218689588 7142582 1801759..1802226 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8544813; Product type lp : lipoprotein; putative outer membrane lipoprotein 1802226 slyB 7142582 slyB Escherichia coli ED1a putative outer membrane lipoprotein YP_002397800.1 1801759 D 585397 CDS YP_002397801.1 218689589 7143806 complement(1802273..1802707) 1 NC_011745.1 Transcription regulator that can both activate or repress expression; transcriptional regulator SlyA 1802707 slyA 7143806 slyA Escherichia coli ED1a transcriptional regulator SlyA YP_002397801.1 1802273 R 585397 CDS YP_002397802.1 218689590 7143805 1802908..1803144 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1803144 ydhI 7143805 ydhI Escherichia coli ED1a hypothetical protein YP_002397802.1 1802908 D 585397 CDS YP_002397803.1 218689591 7139289 1803147..1804004 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12900028; Product type e : enzyme; undecaprenyl pyrophosphate phosphatase 1804004 ydhJ 7139289 ydhJ Escherichia coli ED1a undecaprenyl pyrophosphate phosphatase YP_002397803.1 1803147 D 585397 CDS YP_002397804.1 218689592 7139290 1804004..1806016 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1806016 ydhK 7139290 ydhK Escherichia coli ED1a hypothetical protein YP_002397804.1 1804004 D 585397 CDS YP_002397805.1 218689593 7139291 complement(1806017..1806538) 1 NC_011745.1 SodC; copper and zinc binding; converts superoxide radicals to hydrogen peroxide and water; superoxide dismutase 1806538 sodC 7139291 sodC Escherichia coli ED1a superoxide dismutase YP_002397805.1 1806017 R 585397 CDS YP_002397806.1 218689594 7143816 complement(1806619..1807515) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 1807515 ydhF 7143816 ydhF Escherichia coli ED1a putative oxidoreductase YP_002397806.1 1806619 R 585397 CDS YP_002397807.1 218689595 7139288 1807990..1808505 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1808505 ydhM 7139288 ydhM Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002397807.1 1807990 D 585397 CDS YP_002397808.1 218689596 7139292 1808542..1809639 1 NC_011745.1 FMN-linked; catalyzes the formation of N-ethylsuccinimide from N-ethylmaleimide; N-ethylmaleimide reductase 1809639 nemA 7139292 nemA Escherichia coli ED1a N-ethylmaleimide reductase YP_002397808.1 1808542 D 585397 CDS YP_002397809.1 218689597 7140374 1809720..1810127 1 NC_011745.1 Ni-dependent; catalyzes the formation of S-lactoylglutathione from methylglyoxal and glutathione; glyoxalase I 1810127 gloA 7140374 gloA Escherichia coli ED1a glyoxalase I YP_002397809.1 1809720 D 585397 CDS YP_002397810.1 218689598 7142964 1810230..1810877 1 NC_011745.1 Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A); ribonuclease T 1810877 rnt 7142964 rnt Escherichia coli ED1a ribonuclease T YP_002397810.1 1810230 D 585397 CDS YP_002397811.1 218689599 7141443 complement(1811249..1811596) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15833738, 15840565, 11950925, 12730244; Product type e : enzyme; hypothetical protein 1811596 ydhD 7141443 ydhD Escherichia coli ED1a hypothetical protein YP_002397811.1 1811249 R 585397 CDS YP_002397812.1 218689600 7139287 1811931..1812758 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative exported hydrolase 1812758 ydhO 7139287 ydhO Escherichia coli ED1a putative exported hydrolase YP_002397812.1 1811931 D 585397 CDS YP_002397813.1 218689601 7139293 1812886..1813467 1 NC_011745.1 SodB; iron binding; present under aerobic and anaerobic conditions; destroys free radicals; superoxide dismutase 1813467 sodB 7139293 sodB Escherichia coli ED1a superoxide dismutase YP_002397813.1 1812886 D 585397 CDS YP_002397814.1 218689602 7143815 complement(1813613..1814782) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative efflux protein; MFS family 1814782 ydhP 7143815 ydhP Escherichia coli ED1a putative efflux protein; MFS family YP_002397814.1 1813613 R 585397 CDS YP_002397815.1 218689603 7139294 1815336..1816361 1 NC_011745.1 binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers; DNA-binding transcriptional repressor PurR 1816361 purR 7139294 purR Escherichia coli ED1a DNA-binding transcriptional repressor PurR YP_002397815.1 1815336 D 585397 CDS YP_002397816.1 218689604 7141224 complement(1816358..1817290) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2404765; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1817290 ydhB 7141224 ydhB Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002397816.1 1816358 R 585397 CDS YP_002397817.1 218689605 7139285 1817403..1818614 1 NC_011745.1 uncharacterized member of the major facilitator superfamily (MFS); inner membrane transport protein YdhC 1818614 ydhC 7139285 ydhC Escherichia coli ED1a inner membrane transport protein YdhC YP_002397817.1 1817403 D 585397 CDS YP_002397818.1 218689606 7139286 1818905..1820053 1 NC_011745.1 catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge; cyclopropane fatty acyl phospholipid synthase 1820053 cfa 7139286 cfa Escherichia coli ED1a cyclopropane fatty acyl phospholipid synthase YP_002397818.1 1818905 D 585397 CDS YP_002397819.1 218689607 7139328 complement(1820093..1820734) 1 NC_011745.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 1820734 ribC 7139328 ribC Escherichia coli ED1a riboflavin synthase subunit alpha YP_002397819.1 1820093 R 585397 CDS YP_002397820.1 218689608 7142745 1820949..1822322 1 NC_011745.1 NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones; multidrug efflux protein 1822322 mdtK 7142745 mdtK Escherichia coli ED1a multidrug efflux protein YP_002397820.1 1820949 D 585397 CDS YP_002397821.1 218689609 7142237 complement(1822363..1823619) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1823619 ydhQ 7142237 ydhQ Escherichia coli ED1a hypothetical protein YP_002397821.1 1822363 R 585397 CDS YP_002397822.1 218689610 7140786 1824192..1824497 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1824497 ydhR 7140786 ydhR Escherichia coli ED1a hypothetical protein YP_002397822.1 1824192 D 585397 CDS YP_002397823.1 218689611 7139296 1824623..1826227 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1826227 ydhS 7139296 ydhS Escherichia coli ED1a hypothetical protein YP_002397823.1 1824623 D 585397 CDS YP_002397824.1 218689612 7139297 complement(1826239..1827051) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1827051 ydhT 7139297 ydhT Escherichia coli ED1a hypothetical protein YP_002397824.1 1826239 R 585397 CDS YP_002397825.1 218689613 7139298 complement(1827055..1827840) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative cytochrome b subunit of a reductase 1827840 ydhU 7139298 ydhU Escherichia coli ED1a putative cytochrome b subunit of a reductase YP_002397825.1 1827055 R 585397 CDS YP_002397826.1 218689614 7139299 complement(1827837..1828505) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative 4Fe-4S ferridoxin-type subunit of oxidoreductase 1828505 ydhX 7139299 ydhX Escherichia coli ED1a putative 4Fe-4S ferridoxin-type subunit of oxidoreductase YP_002397826.1 1827837 R 585397 CDS YP_002397827.1 218689615 7139303 complement(1828569..1829216) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1829216 ydhW 7139303 ydhW Escherichia coli ED1a hypothetical protein YP_002397827.1 1828569 R 585397 CDS YP_002397828.1 218689616 7139301 complement(1831344..1831970) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; hypothetical protein 1831970 ydhY 7139301 ydhY Escherichia coli ED1a hypothetical protein YP_002397828.1 1831344 R 585397 CDS YP_002397829.1 218689617 7139304 complement(1832426..1832635) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1832635 ydhZ 7139304 ydhZ Escherichia coli ED1a hypothetical protein YP_002397829.1 1832426 R 585397 CDS YP_002397830.1 218689618 7142524 1833193..1834605 1 NC_011745.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1834605 pykF 7142524 pykF Escherichia coli ED1a pyruvate kinase YP_002397830.1 1833193 D 585397 CDS YP_002397831.1 218689619 7141230 1834916..1835152 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 334727, 338599, 322142, 353292, 391404, 4261992, 4575979, 6765942; Product type lp : lipoprotein; murein lipoprotein 1835152 lpp 7141230 lpp Escherichia coli ED1a murein lipoprotein YP_002397831.1 1834916 D 585397 CDS YP_002397832.1 218689620 7141914 complement(1835215..1836219) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1836219 ynhG 7141914 ynhG Escherichia coli ED1a hypothetical protein YP_002397832.1 1835215 R 585397 CDS YP_002397833.1 218689621 7141018 complement(1836368..1836784) 1 NC_011745.1 Acts with SufS to catalyze the formation of L-alanine from L-cysteine; cysteine desufuration protein SufE 1836784 sufE 7141018 sufE Escherichia coli ED1a cysteine desufuration protein SufE YP_002397833.1 1836368 R 585397 CDS YP_002397834.1 218689622 7141494 complement(1836797..1838017) 1 NC_011745.1 catalyzes the formation of L-alanine and selenide or sulfanylcysteine from selenocysteine or cysteine; bifunctional cysteine desulfurase/selenocysteine lyase 1838017 sufS 7141494 sufS Escherichia coli ED1a bifunctional cysteine desulfurase/selenocysteine lyase YP_002397834.1 1836797 R 585397 CDS YP_002397835.1 218689623 7141496 complement(1838014..1839285) 1 NC_011745.1 with SufBC activates cysteine desulfurase SufS; cysteine desulfurase activator complex subunit SufD 1839285 sufD 7141496 sufD Escherichia coli ED1a cysteine desulfurase activator complex subunit SufD YP_002397835.1 1838014 R 585397 CDS YP_002397836.1 218689624 7141493 complement(1839260..1840006) 1 NC_011745.1 part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE; cysteine desulfurase ATPase 1840006 sufC 7141493 sufC Escherichia coli ED1a cysteine desulfurase ATPase YP_002397836.1 1839260 R 585397 CDS YP_002397837.1 218689625 7141492 complement(1840016..1841503) 1 NC_011745.1 with SufCD activates cysteine desulfurase SufS; cysteine desulfurase activator complex subunit SufB 1841503 sufB 7141492 sufB Escherichia coli ED1a cysteine desulfurase activator complex subunit SufB YP_002397837.1 1840016 R 585397 CDS YP_002397838.1 218689626 7141491 complement(1841512..1841880) 1 NC_011745.1 functions as a scaffold on which iron-sulfur clusters ([2Fe-2S]; [4Fe-4S]) are assembled; forms a homodimer; similar to IscA protein; iron-sulfur cluster assembly scaffold protein 1841880 sufA 7141491 sufA Escherichia coli ED1a iron-sulfur cluster assembly scaffold protein YP_002397838.1 1841512 R 585397 CDS YP_002397839.1 218689627 7140751 complement(1842429..1842698) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1842698 ydiH 7140751 ydiH Escherichia coli ED1a hypothetical protein YP_002397839.1 1842429 R 585397 CDS YP_002397840.1 218689628 7141628 complement(1842717..1843127) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15808744; Product type pe : putative enzyme; hypothetical protein 1843127 ydiI 7141628 ydiI Escherichia coli ED1a hypothetical protein YP_002397840.1 1842717 R 585397 CDS YP_002397841.1 218689629 7141629 complement(1843124..1846180) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11102686; Product type pe : putative enzyme; putative FAD-linked oxidoreductase 1846180 ydiJ 7141629 ydiJ Escherichia coli ED1a putative FAD-linked oxidoreductase YP_002397841.1 1843124 R 585397 CDS YP_002397842.1 218689630 7141630 1846394..1847506 1 NC_011745.1 YdiK; inner membrane protein; ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated; unknown function; putative inner membrane protein 1847506 ydiK 7141630 ydiK Escherichia coli ED1a putative inner membrane protein YP_002397842.1 1846394 D 585397 CDS YP_002397843.1 218689631 7140083 1847935..1848291 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1848291 ydiL 7140083 ydiL Escherichia coli ED1a hypothetical protein YP_002397843.1 1847935 D 585397 CDS YP_002397844.1 218689632 7141632 1848391..1849605 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter 1849605 ydiM 7141632 ydiM Escherichia coli ED1a putative MFS superfamily transporter YP_002397844.1 1848391 D 585397 CDS YP_002397845.1 218689633 7141633 1849832..1851097 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 1851097 ydiN 7141633 ydiN Escherichia coli ED1a putative transporter YP_002397845.1 1849832 D 585397 CDS YP_002397846.1 218689634 7141634 1851109..1851975 1 NC_011745.1 YdiB; quinate/shikimate dehydrogenase from Escherichia coli uses both NAD and NAD(P) to convert quinate and shikimate to 3-dehydroquinate and 3-dehydroshikimate; quinate/shikimate dehydrogenase 1851975 ydiB 7141634 ydiB Escherichia coli ED1a quinate/shikimate dehydrogenase YP_002397846.1 1851109 D 585397 CDS YP_002397847.1 218689635 7141624 1852006..1852764 1 NC_011745.1 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase 1852764 aroD 7141624 aroD Escherichia coli ED1a 3-dehydroquinate dehydratase YP_002397847.1 1852006 D 585397 CDS YP_002397848.1 218689636 7142626 1852909..1854357 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16253988; Product type e : enzyme; short chain acyl-CoA transferase subunit alpha/beta 1854357 ydiF 7142626 ydiF Escherichia coli ED1a short chain acyl-CoA transferase subunit alpha/beta YP_002397848.1 1852909 D 585397 CDS YP_002397849.1 218689637 7141627 complement(1854292..1854795) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 1854795 insB 7141627 insB Escherichia coli ED1a IS1 transposase InsAB' YP_002397849.1 1854292 R 585397 CDS YP_002397850.1 218689638 7141142 complement(1854714..1854989) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 1854989 insA 7141142 insA Escherichia coli ED1a IS1 repressor protein InsA YP_002397850.1 1854714 R 585397 CDS YP_002397851.1 218689639 7141120 1855294..1856445 1 NC_011745.1 may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain; putative acyl-CoA dehydrogenase 1856445 ydiO 7141120 ydiO Escherichia coli ED1a putative acyl-CoA dehydrogenase YP_002397851.1 1855294 D 585397 CDS YP_002397852.1 218689640 7141635 complement(1856488..1857399) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1857399 ydiP 7141635 ydiP Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002397852.1 1856488 R 585397 CDS YP_002397853.1 218689641 7141636 complement(1857502..1857678) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1857678 7141636 ECED1_1898 Escherichia coli ED1a hypothetical protein YP_002397853.1 1857502 R 585397 CDS YP_002397854.1 218689642 7140887 1857715..1858479 1 NC_011745.1 YdiO, YdiQ, YdiR, YdiS, and YdiT may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain; putative electron transfer flavoprotein YdiQ 1858479 ydiQ 7140887 ydiQ Escherichia coli ED1a putative electron transfer flavoprotein YdiQ YP_002397854.1 1857715 D 585397 CDS YP_002397855.1 218689643 7141637 1858499..1859437 1 NC_011745.1 May play a role in a redox process; electron transfer flavoprotein subunit YdiR 1859437 ydiR 7141637 ydiR Escherichia coli ED1a electron transfer flavoprotein subunit YdiR YP_002397855.1 1858499 D 585397 CDS YP_002397856.1 218689644 7141638 1859492..1860781 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; hypothetical protein 1860781 ydiS 7141638 ydiS Escherichia coli ED1a hypothetical protein YP_002397856.1 1859492 D 585397 CDS YP_002397857.1 218689645 7141639 1860778..1861071 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative 4Fe-4S ferredoxin-type oxidoreductase subunit 1861071 ydiT 7141639 ydiT Escherichia coli ED1a putative 4Fe-4S ferredoxin-type oxidoreductase subunit YP_002397857.1 1860778 D 585397 CDS YP_002397858.1 218689646 7141640 1861074..1862774 1 NC_011745.1 acts in anaerobic beta-oxidation of fatty acids; possible ligase/synthase involved in anaerobic growth on fatty acids; short chain acyl-CoA synthetase 1862774 ydiD 7141640 ydiD Escherichia coli ED1a short chain acyl-CoA synthetase YP_002397858.1 1861074 D 585397 CDS YP_002397859.1 218689647 7141625 complement(1862831..1865209) 1 NC_011745.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; phosphoenolpyruvate synthase 1865209 pps 7141625 pps Escherichia coli ED1a phosphoenolpyruvate synthase YP_002397859.1 1862831 R 585397 CDS YP_002397860.1 218689648 7139109 1865542..1866375 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1866375 ydiA 7139109 ydiA Escherichia coli ED1a hypothetical protein YP_002397860.1 1865542 D 585397 CDS YP_002397861.1 218689649 7141623 1866532..1867578 1 NC_011745.1 tryptophan sensitive; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate; phospho-2-dehydro-3-deoxyheptonate aldolase 1867578 aroH 7141623 aroH Escherichia coli ED1a phospho-2-dehydro-3-deoxyheptonate aldolase YP_002397861.1 1866532 D 585397 CDS YP_002397862.1 218689650 7142630 1867710..1867901 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 15039350; hypothetical protein 1867901 ydiE 7142630 ydiE Escherichia coli ED1a hypothetical protein YP_002397862.1 1867710 D 585397 CDS YP_002397863.1 218689651 7141626 complement(1867905..1869341) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1869341 ydiU 7141626 ydiU Escherichia coli ED1a hypothetical protein YP_002397863.1 1867905 R 585397 CDS YP_002397864.1 218689652 7141641 complement(1869404..1870117) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1870117 ydiV 7141641 ydiV Escherichia coli ED1a hypothetical protein YP_002397864.1 1869404 R 585397 CDS YP_002397865.1 218689653 7141642 complement(1870364..1870828) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12620121; Product type lp : lipoprotein; putative peptidase lipoprotein 1870828 nlpC 7141642 nlpC Escherichia coli ED1a putative peptidase lipoprotein YP_002397865.1 1870364 R 585397 CDS YP_002397866.1 218689654 7140399 complement(1870906..1871655) 1 NC_011745.1 ATP-binding protein that acts with the transmembrane protein BtuC and the solute binding protein BtuF to transport vitamin B12 into the cell; vitamin B12-transporter ATPase 1871655 btuD 7140399 btuD Escherichia coli ED1a vitamin B12-transporter ATPase YP_002397866.1 1870906 R 585397 CDS YP_002397867.1 218689655 7140466 complement(1871655..1872206) 1 NC_011745.1 similar to glutathione peroxidase; member of the btuCED operon which is required for vitamin B12 transport across the inner membrane; putative glutathione peroxidase 1872206 btuE 7140466 btuE Escherichia coli ED1a putative glutathione peroxidase YP_002397867.1 1871655 R 585397 CDS YP_002397868.1 218689656 7140467 complement(1872268..1873248) 1 NC_011745.1 with BtuD and BtuF transports vitamin B12 into the cell; vtamin B12-transporter permease 1873248 btuC 7140467 btuC Escherichia coli ED1a vtamin B12-transporter permease YP_002397868.1 1872268 R 585397 CDS YP_002397869.1 218689657 7140465 complement(1873349..1873648) 1 NC_011745.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit alpha 1873648 ihfA 7140465 ihfA Escherichia coli ED1a integration host factor subunit alpha YP_002397869.1 1873349 R 585397 CDS YP_002397870.1 218689658 7140232 complement(1873653..1876040) 1 NC_011745.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 1876040 pheT 7140232 pheT Escherichia coli ED1a phenylalanyl-tRNA synthetase subunit beta YP_002397870.1 1873653 R 585397 CDS YP_002397871.1 218689659 7144086 complement(1876055..1877038) 1 NC_011745.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 1877038 pheS 7144086 pheS Escherichia coli ED1a phenylalanyl-tRNA synthetase subunit alpha YP_002397871.1 1876055 R 585397 CDS YP_002397873.1 218689661 7144083 complement(1877489..1877845) 1 NC_011745.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 1877845 rplT 7144083 rplT Escherichia coli ED1a 50S ribosomal protein L20 YP_002397873.1 1877489 R 585397 CDS YP_002397874.1 218689662 7141469 complement(1877898..1878095) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93085722, 10094780, 3298224, 3542048, 6325158; Product type s : structure; 50S ribosomal protein L35 1878095 rpmI 7141469 rpmI Escherichia coli ED1a 50S ribosomal protein L35 YP_002397874.1 1877898 R 585397 CDS YP_002397875.1 218689663 7141111 complement(1878738..1880666) 1 NC_011745.1 catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; threonyl-tRNA synthetase 1880666 thrS 7141111 thrS Escherichia coli ED1a threonyl-tRNA synthetase YP_002397875.1 1878738 R 585397 CDS YP_002397876.1 218689664 7140891 complement(1882551..1883309) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1883309 ydiY 7140891 ydiY Escherichia coli ED1a hypothetical protein YP_002397876.1 1882551 R 585397 CDS YP_002397877.1 218689665 7141643 1883595..1884524 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 78194149, 88292964, 6235149, 6310120; Product type e : enzyme; 6-phosphofructokinase 2 1884524 pfkB 7141643 pfkB Escherichia coli ED1a 6-phosphofructokinase 2 YP_002397877.1 1883595 D 585397 CDS YP_002397878.1 218689666 7144068 1884625..1884915 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1884915 ydiZ 7144068 ydiZ Escherichia coli ED1a hypothetical protein YP_002397878.1 1884625 D 585397 CDS YP_002397879.1 218689667 7141644 1885021..1885881 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphotransferase/kinase 1885881 yniA 7141644 yniA Escherichia coli ED1a putative phosphotransferase/kinase YP_002397879.1 1885021 D 585397 CDS YP_002397880.1 218689668 7141019 complement(1885922..1886458) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1886458 yniB 7141019 yniB Escherichia coli ED1a hypothetical protein YP_002397880.1 1885922 R 585397 CDS YP_002397881.1 218689669 7141020 1886605..1887273 1 NC_011745.1 YniC; catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate, mannose 6-phosphate and p-nitrophenyl phosphate; 2-deoxyglucose-6-phosphatase 1887273 yniC 7141020 yniC Escherichia coli ED1a 2-deoxyglucose-6-phosphatase YP_002397881.1 1886605 D 585397 CDS YP_002397882.1 218689670 7139918 1887436..1888026 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10760155; Product type pm : putative membrane component; hypothetical protein 1888026 ydjM 7139918 ydjM Escherichia coli ED1a hypothetical protein YP_002397882.1 1887436 D 585397 CDS YP_002397883.1 218689671 7141655 1888159..1889550 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative cation-acid symporter 1889550 ydjN 7141655 ydjN Escherichia coli ED1a putative cation-acid symporter YP_002397883.1 1888159 D 585397 CDS YP_002397884.1 218689672 7141656 complement(1889597..1889860) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9427399; Product type cp : cell process; cell division modulator 1889860 cedA 7141656 cedA Escherichia coli ED1a cell division modulator YP_002397884.1 1889597 R 585397 CDS YP_002397885.1 218689673 7139327 1890043..1892304 1 NC_011745.1 Catalase HPII; monofunctional catalase that decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide; hydroperoxidase II 1892304 katE 7139327 katE Escherichia coli ED1a hydroperoxidase II YP_002397885.1 1890043 D 585397 CDS YP_002397886.1 218689674 7142484 complement(1892350..1893108) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 20042356, 1987146, 2179047, 8121401, 9405618; hypothetical protein 1893108 chbG 7142484 chbG Escherichia coli ED1a hypothetical protein YP_002397886.1 1892350 R 585397 CDS YP_002397887.1 218689675 7139336 complement(1893121..1894473) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20042356, 90185127, 9405618; Product type e : enzyme; cryptic phospho-beta-glucosidase, NAD(P)-binding 1894473 chbF 7139336 chbF Escherichia coli ED1a cryptic phospho-beta-glucosidase, NAD(P)-binding YP_002397887.1 1893121 R 585397 CDS YP_002397888.1 218689676 7139335 complement(1894577..1895419) 1 NC_011745.1 represses the celABCDF-ydjC operon involved in carbon uptake; DNA-binding transcriptional regulator ChbR 1895419 chbR 7139335 chbR Escherichia coli ED1a DNA-binding transcriptional regulator ChbR YP_002397888.1 1894577 R 585397 CDS YP_002397889.1 218689677 7139337 complement(1895427..1895777) 1 NC_011745.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIA 1895777 chbA 7139337 chbA Escherichia coli ED1a PTS system N,N'-diacetylchitobiose-specific transporter subunit IIA YP_002397889.1 1895427 R 585397 CDS YP_002397890.1 218689678 7139332 complement(1895828..1897186) 1 NC_011745.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC 1897186 chbC 7139332 chbC Escherichia coli ED1a PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC YP_002397890.1 1895828 R 585397 CDS YP_002397891.1 218689679 7139334 complement(1897271..1897591) 1 NC_011745.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIB 1897591 chbB 7139334 chbB Escherichia coli ED1a PTS system N,N'-diacetylchitobiose-specific transporter subunit IIB YP_002397891.1 1897271 R 585397 CDS YP_002397892.1 218689680 7139333 complement(1897890..1898228) 1 NC_011745.1 osmotically-inducible lipoprotein E; activator of ntr-like gene protein; DNA-binding transcriptional activator OsmE 1898228 osmE 7139333 osmE Escherichia coli ED1a DNA-binding transcriptional activator OsmE YP_002397892.1 1897890 R 585397 CDS YP_002397893.1 218689681 7139989 1898430..1899257 1 NC_011745.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase 1899257 nadE 7139989 nadE Escherichia coli ED1a NAD synthetase YP_002397893.1 1898430 D 585397 CDS YP_002397894.1 218689682 7140334 1899487..1900374 1 NC_011745.1 3' incision activity; acts with UvrC; nucleotide excision repair endonuclease 1900374 ydjQ 7140334 ydjQ Escherichia coli ED1a nucleotide excision repair endonuclease YP_002397894.1 1899487 D 585397 CDS YP_002397895.1 218689683 7141657 complement(1900334..1900909) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 21862596; hypothetical protein 1900909 ydjR 7141657 ydjR Escherichia coli ED1a hypothetical protein YP_002397895.1 1900334 R 585397 CDS YP_002397896.1 218689684 7141658 complement(1901112..1901597) 1 NC_011745.1 periplasmic protein induced by stress response via Cpx and BaeSR system; similar to CpxP; periplasmic protein 1901597 spy 7141658 spy Escherichia coli ED1a periplasmic protein YP_002397896.1 1901112 R 585397 CDS YP_002397897.1 218689685 7143835 complement(1901927..1902895) 1 NC_011745.1 catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism; succinylglutamate desuccinylase 1902895 astE 7143835 astE Escherichia coli ED1a succinylglutamate desuccinylase YP_002397897.1 1901927 R 585397 CDS YP_002397898.1 218689686 7142658 complement(1902888..1904231) 1 NC_011745.1 catalyzes the hydrolysis of 2-N-succinylarginine into 2-N-succinylornithine, ammonia and carbon dioxide in arginine degradation; succinylarginine dihydrolase 1904231 astB 7142658 astB Escherichia coli ED1a succinylarginine dihydrolase YP_002397898.1 1902888 R 585397 CDS YP_002397899.1 218689687 7142655 complement(1904228..1905706) 1 NC_011745.1 a high throughput screen identified this enzyme as an aldehyde dehydrogenase with broad substrate specificity; converts succinylglutamate semialdehyde and NAD to succinylglutamate and NADH; succinylglutamic semialdehyde dehydrogenase 1905706 astD 7142655 astD Escherichia coli ED1a succinylglutamic semialdehyde dehydrogenase YP_002397899.1 1904228 R 585397 CDS YP_002397900.1 218689688 7142657 complement(1905703..1906737) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14675764, 98361920; Product type e : enzyme; arginine succinyltransferase 1906737 astA 7142657 astA Escherichia coli ED1a arginine succinyltransferase YP_002397900.1 1905703 R 585397 CDS YP_002397901.1 218689689 7142654 complement(1906734..1907954) 1 NC_011745.1 catalyzes the transamination of 2-N-succinylornithine and alpha-ketoglutarate into 2-N-succinylglutamate semialdehyde and glutamate; also functions as the catabolic acetylornithine aminotransferase catalyzing the formation of 2-N-acetylglutamate semialdehyde and glutamate from 2-N-acetylornithine and alpha-ketoglutarate; bifunctional succinylornithine transaminase/acetylornithine transaminase 1907954 astC 7142654 astC Escherichia coli ED1a bifunctional succinylornithine transaminase/acetylornithine transaminase YP_002397901.1 1906734 R 585397 CDS YP_002397902.1 218689690 7142656 1908400..1909206 1 NC_011745.1 removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction; exonuclease III 1909206 xthA 7142656 xthA Escherichia coli ED1a exonuclease III YP_002397902.1 1908400 D 585397 CDS YP_002397903.1 218689691 7139211 1909373..1910083 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1910083 ydjX 7139211 ydjX Escherichia coli ED1a hypothetical protein YP_002397903.1 1909373 D 585397 CDS YP_002397904.1 218689692 7141659 1910088..1910765 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1910765 ydjY 7141659 ydjY Escherichia coli ED1a hypothetical protein YP_002397904.1 1910088 D 585397 CDS YP_002397905.1 218689693 7141660 1910779..1911486 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1911486 ydjZ 7141660 ydjZ Escherichia coli ED1a hypothetical protein YP_002397905.1 1910779 D 585397 CDS YP_002397906.1 218689694 7141661 1911486..1912034 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1912034 ynjA 7141661 ynjA Escherichia coli ED1a hypothetical protein YP_002397906.1 1911486 D 585397 CDS YP_002397907.1 218689695 7140243 1912044..1913210 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative ABC transporter solute-binding protein 1913210 ynjB 7140243 ynjB Escherichia coli ED1a putative ABC transporter solute-binding protein YP_002397907.1 1912044 D 585397 CDS YP_002397908.1 218689696 7140244 1913228..1914718 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; fused putative transporter subunits of ABC superfamily: membrane components 1914718 ynjC 7140244 ynjC Escherichia coli ED1a fused putative transporter subunits of ABC superfamily: membrane components YP_002397908.1 1913228 D 585397 CDS YP_002397909.1 218689697 7140245 1914718..1915371 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sulfate/thiosulfate ABC transporter ATP-binding protein transporter 1915371 ynjD 7140245 ynjD Escherichia coli ED1a putative sulfate/thiosulfate ABC transporter ATP-binding protein transporter YP_002397909.1 1914718 D 585397 CDS YP_002397910.1 218689698 7140246 1915438..1916745 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative exported thiosulfate sulfur transferase / thiosulfate binding protein 1916745 ynjE 7140246 ynjE Escherichia coli ED1a putative exported thiosulfate sulfur transferase / thiosulfate binding protein YP_002397910.1 1915438 D 585397 CDS YP_002397911.1 218689699 7140247 complement(1916754..1917374) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type m : membrane component; putative phosphatidyl transferase, inner membrane protein 1917374 ynjF 7140247 ynjF Escherichia coli ED1a putative phosphatidyl transferase, inner membrane protein YP_002397911.1 1916754 R 585397 CDS YP_002397912.1 218689700 7140248 1917461..1917868 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21101911; Product type e : enzyme; pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase 1917868 nudG 7140248 nudG Escherichia coli ED1a pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase YP_002397912.1 1917461 D 585397 CDS YP_002397913.1 218689701 7139942 1918342..1919685 1 NC_011745.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 1919685 gdhA 7139942 gdhA Escherichia coli ED1a glutamate dehydrogenase YP_002397913.1 1918342 D 585397 CDS YP_002397914.1 218689702 7143173 complement(1919762..1921774) 1 NC_011745.1 decatenates replicating daughter chromosomes; DNA topoisomerase III 1921774 topB 7143173 topB Escherichia coli ED1a DNA topoisomerase III YP_002397914.1 1919762 R 585397 CDS YP_002397915.1 218689703 7140791 complement(1921722..1922765) 1 NC_011745.1 catalyzes the formation of selenophosphate from selenide and ATP; selenophosphate synthetase 1922765 selD 7140791 selD Escherichia coli ED1a selenophosphate synthetase YP_002397915.1 1921722 R 585397 CDS YP_002397916.1 218689704 7141395 complement(1922707..1922856) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1922856 7141395 ECED1_1965 Escherichia coli ED1a hypothetical protein YP_002397916.1 1922707 R 585397 CDS YP_002397917.1 218689705 7140892 complement(1922882..1923433) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 1923433 ydjA 7140892 ydjA Escherichia coli ED1a hypothetical protein YP_002397917.1 1922882 R 585397 CDS YP_002397918.1 218689706 7141645 1923487..1923651 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1923651 7141645 ECED1_1967 Escherichia coli ED1a hypothetical protein YP_002397918.1 1923487 D 585397 CDS YP_002397919.1 218689707 7140893 1923594..1925450 1 NC_011745.1 SppA; catalyzes the degradation of cleaved signal peptides; essential to maintain secretion of mature proteins across the membrane; protease 4 1925450 sppA 7140893 sppA Escherichia coli ED1a protease 4 YP_002397919.1 1923594 D 585397 CDS YP_002397920.1 218689708 7143832 1925617..1926633 1 NC_011745.1 converts asparagine to aspartate and ammonia; cytoplasmic asparaginase I 1926633 ansA 7143832 ansA Escherichia coli ED1a cytoplasmic asparaginase I YP_002397920.1 1925617 D 585397 CDS YP_002397921.1 218689709 7142583 1926644..1927285 1 NC_011745.1 catalyzes the formation of nicotinate from nicotinamide in NAD biosynthesis and the formation of pyrazinoate from pyrazinamide; nicotinamidase/pyrazinamidase 1927285 pncA 7142583 pncA Escherichia coli ED1a nicotinamidase/pyrazinamidase YP_002397921.1 1926644 D 585397 CDS YP_002397922.1 218689710 7139075 complement(1927378..1928736) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter 1928736 ydjE 7139075 ydjE Escherichia coli ED1a putative MFS superfamily transporter YP_002397922.1 1927378 R 585397 CDS YP_002397923.1 218689711 7141646 1928709..1928852 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1928852 7141646 ECED1_1972 Escherichia coli ED1a hypothetical protein YP_002397923.1 1928709 D 585397 CDS YP_002397924.1 218689712 7140894 complement(1928854..1929612) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1929612 ydjF 7140894 ydjF Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002397924.1 1928854 R 585397 CDS YP_002397925.1 218689713 7141649 complement(1930739..1931686) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sugar kinase 1931686 ydjH 7141649 ydjH Escherichia coli ED1a putative sugar kinase YP_002397925.1 1930739 R 585397 CDS YP_002397926.1 218689714 7141650 complement(1931691..1932527) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative aldolase 1932527 ydjI 7141650 ydjI Escherichia coli ED1a putative aldolase YP_002397926.1 1931691 R 585397 CDS YP_002397927.1 218689715 7141651 complement(1932548..1933591) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12897001; Product type pe : putative enzyme; putative iditol dehydrogenase 1933591 ydjJ 7141651 ydjJ Escherichia coli ED1a putative iditol dehydrogenase YP_002397927.1 1932548 R 585397 CDS YP_002397928.1 218689716 7141652 complement(1933608..1934987) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter 1934987 ydjK 7141652 ydjK Escherichia coli ED1a putative MFS superfamily transporter YP_002397928.1 1933608 R 585397 CDS YP_002397929.1 218689717 7141653 complement(1935014..1936090) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase, Zn-dependent and NAD(P)-binding 1936090 ydjL 7141653 ydjL Escherichia coli ED1a putative oxidoreductase, Zn-dependent and NAD(P)-binding YP_002397929.1 1935014 R 585397 CDS YP_002397930.1 218689718 7141654 complement(1936460..1936732) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1936732 yeaC 7141654 yeaC Escherichia coli ED1a hypothetical protein YP_002397930.1 1936460 R 585397 CDS YP_002397931.1 218689719 7141663 complement(1936774..1937187) 1 NC_011745.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress; methionine sulfoxide reductase B 1937187 msrB 7141663 msrB Escherichia coli ED1a methionine sulfoxide reductase B YP_002397931.1 1936774 R 585397 CDS YP_002397932.1 218689720 7139035 1937529..1938524 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 775311, 94131963, 98361923, 1862091, 2124629, 2990926, 7896119, 8636984, 9298646; Product type e : enzyme; glyceraldehyde-3-phosphate dehydrogenase A 1938524 gapA 7139035 gapA Escherichia coli ED1a glyceraldehyde-3-phosphate dehydrogenase A YP_002397932.1 1937529 D 585397 CDS YP_002397933.1 218689721 7143157 1938608..1939492 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1939492 yeaD 7143157 yeaD Escherichia coli ED1a hypothetical protein YP_002397933.1 1938608 D 585397 CDS YP_002397934.1 218689722 7141664 complement(1939543..1940397) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 1940397 yeaE 7141664 yeaE Escherichia coli ED1a putative oxidoreductase YP_002397934.1 1939543 R 585397 CDS YP_002397935.1 218689723 7141665 complement(1940487..1941233) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10037771, 20267815; Product type f : factor; scaffolding protein for murein synthesizing machinery 1941233 mipA 7141665 mipA Escherichia coli ED1a scaffolding protein for murein synthesizing machinery YP_002397935.1 1940487 R 585397 CDS YP_002397936.1 218689724 7138988 1941669..1943603 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1943603 yeaG 7138988 yeaG Escherichia coli ED1a hypothetical protein YP_002397936.1 1941669 D 585397 CDS YP_002397937.1 218689725 7141666 1943716..1944999 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1944999 yeaH 7141666 yeaH Escherichia coli ED1a hypothetical protein YP_002397937.1 1943716 D 585397 CDS YP_002397938.1 218689726 7141667 1945146..1946621 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative diguanylate cyclase 1946621 yeaI 7141667 yeaI Escherichia coli ED1a putative diguanylate cyclase YP_002397938.1 1945146 D 585397 CDS YP_002397939.1 218689727 7141670 1948335..1948838 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1948838 yeaK 7141670 yeaK Escherichia coli ED1a hypothetical protein YP_002397939.1 1948335 D 585397 CDS YP_002397940.1 218689728 7141671 complement(1948839..1948991) 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 1948991 7141671 ECED1_1994 Escherichia coli ED1a hypothetical protein YP_002397940.1 1948839 R 585397 CDS YP_002397941.1 218689729 7140895 1949113..1949559 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1949559 yeaL 7140895 yeaL Escherichia coli ED1a hypothetical protein YP_002397941.1 1949113 D 585397 CDS YP_002397942.1 218689730 7141672 complement(1949516..1950337) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1950337 yeaM 7141672 yeaM Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002397942.1 1949516 R 585397 CDS YP_002397943.1 218689731 7141673 1950434..1951615 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter 1951615 yeaN 7141673 yeaN Escherichia coli ED1a putative MFS superfamily transporter YP_002397943.1 1950434 D 585397 CDS YP_002397944.1 218689732 7141674 1951670..1952017 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1952017 yeaO 7141674 yeaO Escherichia coli ED1a hypothetical protein YP_002397944.1 1951670 D 585397 CDS YP_002397945.1 218689733 7141675 complement(1952039..1952293) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1952293 yoaF 7141675 yoaF Escherichia coli ED1a hypothetical protein YP_002397945.1 1952039 R 585397 CDS YP_002397946.1 218689734 7140253 1952476..1953501 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative diguanylate cyclase 1953501 yeaP 7140253 yeaP Escherichia coli ED1a putative diguanylate cyclase YP_002397946.1 1952476 D 585397 CDS YP_002397947.1 218689735 7141676 complement(1953768..1954016) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1954016 yeaQ 7141676 yeaQ Escherichia coli ED1a hypothetical protein YP_002397947.1 1953768 R 585397 CDS YP_002397948.1 218689736 7141677 complement(1954164..1954346) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1954346 yoaG 7141677 yoaG Escherichia coli ED1a hypothetical protein YP_002397948.1 1954164 R 585397 CDS YP_002397949.1 218689737 7140254 complement(1954350..1954709) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1954709 yeaR 7140254 yeaR Escherichia coli ED1a hypothetical protein YP_002397949.1 1954350 R 585397 CDS YP_002397950.1 218689738 7141678 complement(1954882..1955520) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; leucine export protein LeuE 1955520 yeaS 7141678 yeaS Escherichia coli ED1a leucine export protein LeuE YP_002397950.1 1954882 R 585397 CDS YP_002397951.1 218689739 7141679 complement(1955647..1955979) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative LuxR family transcription regulator 1955979 7141679 ECED1_2005 Escherichia coli ED1a putative LuxR family transcription regulator YP_002397951.1 1955647 R 585397 CDS YP_002397952.1 218689740 7141680 complement(1956063..1957190) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88289400, 89053950, 93015723, 8107670; Product type e : enzyme; ribonuclease D 1957190 rnd 7141680 rnd Escherichia coli ED1a ribonuclease D YP_002397952.1 1956063 R 585397 CDS YP_002397953.1 218689741 7141434 complement(1957260..1958945) 1 NC_011745.1 Activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 1958945 fadD 7141434 fadD Escherichia coli ED1a long-chain-fatty-acid--CoA ligase YP_002397953.1 1957260 R 585397 CDS YP_002397954.1 218689742 7144126 complement(1959150..1959731) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16079137; Product type lp : lipoprotein; putative outer membrane-associated lipoprotein 1959731 yeaY 7144126 yeaY Escherichia coli ED1a putative outer membrane-associated lipoprotein YP_002397954.1 1959150 R 585397 CDS YP_002397955.1 218689743 7141681 complement(1959771..1960466) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative peptidase 1960466 yeaZ 7141681 yeaZ Escherichia coli ED1a putative peptidase YP_002397955.1 1959771 R 585397 CDS YP_002397956.1 218689744 7141682 complement(1960524..1962434) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ATP-dependent helicase 1962434 yoaA 7141682 yoaA Escherichia coli ED1a putative ATP-dependent helicase YP_002397956.1 1960524 R 585397 CDS YP_002397957.1 218689745 7140249 1962566..1962910 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1962910 yoaB 7140249 yoaB Escherichia coli ED1a hypothetical protein YP_002397957.1 1962566 D 585397 CDS YP_002397958.1 218689746 7140250 1963272..1963631 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1963631 yoaC 7140250 yoaC Escherichia coli ED1a hypothetical protein YP_002397958.1 1963272 D 585397 CDS YP_002397959.1 218689747 7140251 complement(1963751..1963930) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1963930 yoaH 7140251 yoaH Escherichia coli ED1a hypothetical protein YP_002397959.1 1963751 R 585397 CDS YP_002397960.1 218689748 7140255 1964004..1965365 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88025006, 91067712, 91302313, 96011382, 6330050, 7896119; Product type e : enzyme; aminodeoxychorismate synthase subunit I 1965365 pabB 7140255 pabB Escherichia coli ED1a aminodeoxychorismate synthase subunit I YP_002397960.1 1964004 D 585397 CDS YP_002397961.1 218689749 7144036 1965369..1965947 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7567469; Product type pe : putative enzyme; hypothetical protein 1965947 yeaB 7144036 yeaB Escherichia coli ED1a hypothetical protein YP_002397961.1 1965369 D 585397 CDS YP_002397962.1 218689750 7141662 1966131..1967495 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15155761, 89359152, 91056090, 93170282; Product type e : enzyme; L-serine deaminase I 1967495 sdaA 7141662 sdaA Escherichia coli ED1a L-serine deaminase I YP_002397962.1 1966131 D 585397 CDS YP_002397963.1 218689751 7141377 1967626..1969224 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16513732; Product type pe : putative enzyme; putative cyclic di-GMP phosphodiesterase 1969224 adrB 7141377 adrB Escherichia coli ED1a putative cyclic di-GMP phosphodiesterase YP_002397963.1 1967626 D 585397 CDS YP_002397964.1 218689752 7143666 complement(1969228..1970784) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 1970784 yoaE 7143666 yoaE Escherichia coli ED1a hypothetical protein YP_002397964.1 1969228 R 585397 CDS YP_002397965.1 218689753 7140252 1971248..1972219 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87165962, 90036983, 8131846, 8676384, 9074635, 9298646; Product type t : transporter; fused mannose-specific PTS enzymes: IIA component ; IIB component 1972219 manX 7140252 manX Escherichia coli ED1a fused mannose-specific PTS enzymes: IIA component ; IIB component YP_002397965.1 1971248 D 585397 CDS YP_002397966.1 218689754 7142208 1972282..1973082 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10473571, 87165962, 90036983, 94086520, 97128775, 7811395, 8774730; Product type t : transporter; PTS system mannose-specific protein subunit IIC 1973082 manY 7142208 manY Escherichia coli ED1a PTS system mannose-specific protein subunit IIC YP_002397966.1 1972282 D 585397 CDS YP_002397967.1 218689755 7142209 1973086..1973946 1 NC_011745.1 hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel; PTS system mannose-specific transporter subunit IID 1973946 manZ 7142209 manZ Escherichia coli ED1a PTS system mannose-specific transporter subunit IID YP_002397967.1 1973086 D 585397 CDS YP_002397968.1 218689756 7142210 1974001..1974459 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1974459 yobD 7142210 yobD Escherichia coli ED1a hypothetical protein YP_002397968.1 1974001 D 585397 CDS YP_002397969.1 218689757 7140753 1974888..1975454 1 NC_011745.1 membrane protein YebN; hypothetical protein 1975454 yebN 7140753 yebN Escherichia coli ED1a hypothetical protein YP_002397969.1 1974888 D 585397 CDS YP_002397970.1 218689758 7141690 complement(1975451..1976260) 1 NC_011745.1 methylates the guanosine in position 745 of 23S rRNA; required for translation and cell growth; 23S rRNA methyltransferase A 1976260 rrmA 7141690 rrmA Escherichia coli ED1a 23S rRNA methyltransferase A YP_002397970.1 1975451 R 585397 CDS YP_002397971.1 218689759 7140106 complement(1976426..1976635) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20345064, 21101802, 94293754, 12071744, 7984109, 8022261, 9298646, 9868784, 9921691; Product type f : factor; cold shock-like protein CspC 1976635 cspC 7140106 cspC Escherichia coli ED1a cold shock-like protein CspC YP_002397971.1 1976426 R 585397 CDS YP_002397972.1 218689760 7142070 complement(1976648..1976791) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1976791 yobF 7142070 yobF Escherichia coli ED1a hypothetical protein YP_002397972.1 1976648 R 585397 CDS YP_002397973.1 218689761 7140259 complement(1977461..1977748) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1977748 yebO 7140259 yebO Escherichia coli ED1a hypothetical protein YP_002397973.1 1977461 R 585397 CDS YP_002397974.1 218689762 7141691 complement(1977823..1977966) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1977966 yobG 7141691 yobG Escherichia coli ED1a hypothetical protein YP_002397974.1 1977823 R 585397 CDS YP_002397975.1 218689763 7140260 1978125..1978364 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1978364 yobH 7140260 yobH Escherichia coli ED1a hypothetical protein YP_002397975.1 1978125 D 585397 CDS YP_002397976.1 218689764 7140261 complement(1978508..1979299) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15659677, 4359651; Product type r : regulator; DNA-binding transcriptional repressor KdgR 1979299 kdgR 7140261 kdgR Escherichia coli ED1a DNA-binding transcriptional repressor KdgR YP_002397976.1 1978508 R 585397 CDS YP_002397977.1 218689765 7142491 1979476..1980849 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter 1980849 yebQ 7142491 yebQ Escherichia coli ED1a putative MFS superfamily transporter YP_002397977.1 1979476 D 585397 CDS YP_002397978.1 218689766 7141692 complement(1980895..1981776) 1 NC_011745.1 putative metalloprotease; heat shock protein HtpX 1981776 htpX 7141692 htpX Escherichia coli ED1a heat shock protein HtpX YP_002397978.1 1980895 R 585397 CDS YP_002397979.1 218689767 7140173 complement(1981968..1984016) 1 NC_011745.1 Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3; carboxy-terminal protease 1984016 prc 7140173 prc Escherichia coli ED1a carboxy-terminal protease YP_002397979.1 1981968 R 585397 CDS YP_002397980.1 218689768 7139114 complement(1984036..1984734) 1 NC_011745.1 affects solute and DNA transport through an unknown mechanism; putative solute/DNA competence effector 1984734 proQ 7139114 proQ Escherichia coli ED1a putative solute/DNA competence effector YP_002397980.1 1984036 R 585397 CDS YP_002397981.1 218689769 7139131 complement(1984831..1985382) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1985382 yebR 7139131 yebR Escherichia coli ED1a hypothetical protein YP_002397981.1 1984831 R 585397 CDS YP_002397982.1 218689770 7141693 1985458..1986741 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1986741 yebS 7141693 yebS Escherichia coli ED1a hypothetical protein YP_002397982.1 1985458 D 585397 CDS YP_002397983.1 218689771 7141694 1986710..1989343 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1989343 yebT 7141694 yebT Escherichia coli ED1a hypothetical protein YP_002397983.1 1986710 D 585397 CDS YP_002397984.1 218689772 7141695 1989423..1990862 1 NC_011745.1 in Escherichia coli this enzyme specifically methylates C1407 of the 16S rRNA; rRNA (cytosine-C(5)-)-methyltransferase RsmF 1990862 yebU 7141695 yebU Escherichia coli ED1a rRNA (cytosine-C(5)-)-methyltransferase RsmF YP_002397984.1 1989423 D 585397 CDS YP_002397985.1 218689773 7141696 1990980..1991216 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1991216 yebV 7141696 yebV Escherichia coli ED1a hypothetical protein YP_002397985.1 1990980 D 585397 CDS YP_002397986.1 218689774 7141697 1991237..1991512 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1991512 yebW 7141697 yebW Escherichia coli ED1a hypothetical protein YP_002397986.1 1991237 D 585397 CDS YP_002397987.1 218689775 7141698 complement(1991513..1992169) 1 NC_011745.1 Plays a key role in signaling protein misfolding via the cpxR/cpxA transducing system; modulates the phosphorylated status of many phosphoproteins; serine/threonine protein phosphatase 1 1992169 pphA 7141698 pphA Escherichia coli ED1a serine/threonine protein phosphatase 1 YP_002397987.1 1991513 R 585397 CDS YP_002397988.1 218689776 7140154 complement(1992394..1992546) 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 1992546 7140154 ECED1_2043 Escherichia coli ED1a hypothetical protein YP_002397988.1 1992394 R 585397 CDS YP_002397989.1 218689777 7140897 complement(1992564..1992905) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1992905 yebY 7140897 yebY Escherichia coli ED1a hypothetical protein YP_002397989.1 1992564 R 585397 CDS YP_002397990.1 218689778 7141699 complement(1992918..1993790) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1993790 yebZ 7141699 yebZ Escherichia coli ED1a hypothetical protein YP_002397990.1 1992918 R 585397 CDS YP_002397991.1 218689779 7141700 complement(1993794..1994168) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1994168 yobA 7141700 yobA Escherichia coli ED1a hypothetical protein YP_002397991.1 1993794 R 585397 CDS YP_002397992.1 218689780 7140256 1994307..1994537 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15090519, 92147649, 92156151, 94131961, 1575709, 8341603, 8505306; Product type e : enzyme; DNA polymerase III subunit theta 1994537 holE 7140256 holE Escherichia coli ED1a DNA polymerase III subunit theta YP_002397992.1 1994307 D 585397 CDS YP_002397993.1 218689781 7139914 1994639..1995295 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1995295 yobB 7139914 yobB Escherichia coli ED1a hypothetical protein YP_002397993.1 1994639 D 585397 CDS YP_002397994.1 218689782 7140257 1995318..1995980 1 NC_011745.1 3'-5' exonuclease activity on single or double-strand DNA; exodeoxyribonuclease X 1995980 exoX 7140257 exoX Escherichia coli ED1a exodeoxyribonuclease X YP_002397994.1 1995318 D 585397 CDS YP_002397995.1 218689783 7139833 complement(1995977..1998037) 1 NC_011745.1 PtrB; oligopeptidase that cleaves peptide bonds following arginine and lysine residues; protease 2 1998037 ptrB 7139833 ptrB Escherichia coli ED1a protease 2 YP_002397995.1 1995977 R 585397 CDS YP_002397996.1 218689784 7141204 complement(1998246..1998905) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1998905 yebE 7141204 yebE Escherichia coli ED1a hypothetical protein YP_002397996.1 1998246 R 585397 CDS YP_002397997.1 218689785 7141686 complement(1999232..1999600) 1 NC_011745.1 secreted protein; unknown function; hypothetical protein 1999600 yebF 7141686 yebF Escherichia coli ED1a hypothetical protein YP_002397997.1 1999232 R 585397 CDS YP_002397998.1 218689786 7141687 complement(1999655..1999945) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9368369, 99403401; Product type cp : cell process; DNA damage-inducible protein YebG 1999945 yebG 7141687 yebG Escherichia coli ED1a DNA damage-inducible protein YebG YP_002397998.1 1999655 R 585397 CDS YP_002397999.1 218689787 7141688 2000079..2001257 1 NC_011745.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis; phosphoribosylglycinamide formyltransferase 2 2001257 purT 7141688 purT Escherichia coli ED1a phosphoribosylglycinamide formyltransferase 2 YP_002397999.1 2000079 D 585397 CDS YP_002398000.1 218689788 7141225 complement(2001300..2001941) 1 NC_011745.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase 2001941 eda 7141225 eda Escherichia coli ED1a keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase YP_002398000.1 2001300 R 585397 CDS YP_002398001.1 218689789 7139772 complement(2001978..2003789) 1 NC_011745.1 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate; phosphogluconate dehydratase 2003789 edd 7139772 edd Escherichia coli ED1a phosphogluconate dehydratase YP_002398001.1 2001978 R 585397 CDS YP_002398002.1 218689790 7139773 complement(2004024..2005499) 1 NC_011745.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 2005499 zwf 7139773 zwf Escherichia coli ED1a glucose-6-phosphate 1-dehydrogenase YP_002398002.1 2004024 R 585397 CDS YP_002398003.1 218689791 7143200 2005837..2006706 1 NC_011745.1 Represses the expression of the zwf, eda, glp and gap; DNA-binding transcriptional regulator HexR 2006706 yebK 7143200 yebK Escherichia coli ED1a DNA-binding transcriptional regulator HexR YP_002398003.1 2005837 D 585397 CDS YP_002398004.1 218689792 7141689 2006834..2008276 1 NC_011745.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 2008276 pykA 7141689 pykA Escherichia coli ED1a pyruvate kinase YP_002398004.1 2006834 D 585397 CDS YP_002398005.1 218689793 7141229 complement(2008408..2009379) 1 NC_011745.1 Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase 2009379 lpxM 7141229 lpxM Escherichia coli ED1a lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase YP_002398005.1 2008408 R 585397 CDS YP_002398006.1 218689794 7141924 complement(2009498..2010820) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1732206; Product type pe : putative enzyme; hypothetical protein 2010820 yebA 7141924 yebA Escherichia coli ED1a hypothetical protein YP_002398006.1 2009498 R 585397 CDS YP_002398007.1 218689795 7141683 complement(2010836..2011768) 1 NC_011745.1 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter periplasmic component 2011768 znuA 7141683 znuA Escherichia coli ED1a high-affinity zinc transporter periplasmic component YP_002398007.1 2010836 R 585397 CDS YP_002398008.1 218689796 7143278 2011847..2012602 1 NC_011745.1 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter ATPase 2012602 znuC 7143278 znuC Escherichia coli ED1a high-affinity zinc transporter ATPase YP_002398008.1 2011847 D 585397 CDS YP_002398009.1 218689797 7143280 2012599..2013384 1 NC_011745.1 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter membrane component 2013384 znuB 7143280 znuB Escherichia coli ED1a high-affinity zinc transporter membrane component YP_002398009.1 2012599 D 585397 CDS YP_002398010.1 218689798 7143279 complement(2013529..2014539) 1 NC_011745.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 2014539 ruvB 7143279 ruvB Escherichia coli ED1a Holliday junction DNA helicase RuvB YP_002398010.1 2013529 R 585397 CDS YP_002398011.1 218689799 7140147 complement(2014548..2015159) 1 NC_011745.1 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 2015159 ruvA 7140147 ruvA Escherichia coli ED1a Holliday junction DNA helicase RuvA YP_002398011.1 2014548 R 585397 CDS YP_002398012.1 218689800 7140146 2015434..2016036 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2016036 yebB 7140146 yebB Escherichia coli ED1a hypothetical protein YP_002398012.1 2015434 D 585397 CDS YP_002398013.1 218689801 7141684 complement(2016038..2016559) 1 NC_011745.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 2016559 ruvC 7141684 ruvC Escherichia coli ED1a Holliday junction resolvase YP_002398013.1 2016038 R 585397 CDS YP_002398014.1 218689802 7140148 complement(2016594..2017334) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2017334 yebC 7140148 yebC Escherichia coli ED1a hypothetical protein YP_002398014.1 2016594 R 585397 CDS YP_002398015.1 218689803 7141685 complement(2017363..2017806) 1 NC_011745.1 converts dATP to dAMP and pyrophosphate; dATP pyrophosphohydrolase 2017806 ntpA 7141685 ntpA Escherichia coli ED1a dATP pyrophosphohydrolase YP_002398015.1 2017363 R 585397 CDS YP_002398016.1 218689804 7139937 complement(2017808..2019580) 1 NC_011745.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 2019580 aspS 7139937 aspS Escherichia coli ED1a aspartyl-tRNA synthetase YP_002398016.1 2017808 R 585397 CDS YP_002398017.1 218689805 7142651 2019890..2020456 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 2020456 yecD 7142651 yecD Escherichia coli ED1a hypothetical protein YP_002398017.1 2019890 D 585397 CDS YP_002398018.1 218689806 7141703 2020811..2021059 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative damage-inducible protein dinI-like 2021059 7141703 ECED1_2074 Escherichia coli ED1a putative damage-inducible protein dinI-like YP_002398018.1 2020811 D 585397 CDS YP_002398019.1 218689807 7140898 complement(2021426..2025451) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10722621, 17220264, 9194704, 9743528; Product type e : enzyme; peptidase S6, IgA endopeptidase from phage origin 2025451 eaaA 7140898 eaaA Escherichia coli ED1a peptidase S6, IgA endopeptidase from phage origin YP_002398019.1 2021426 R 585397 CDS YP_002398020.1 218689808 7139761 complement(2025725..2026195) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10722621; hypothetical protein 2026195 7139761 ECED1_2076 Escherichia coli ED1a hypothetical protein YP_002398020.1 2025725 R 585397 CDS YP_002398021.1 218689809 7140899 complement(2026283..2027836) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10722621; Product type h : extrachromosomal origin; Immunoglobulin-binding protein from prophage P-EibD 2027836 eibD 7140899 eibD Escherichia coli ED1a Immunoglobulin-binding protein from prophage P-EibD YP_002398021.1 2026283 R 585397 CDS YP_002398022.1 218689810 7139780 complement(2027817..2028041) 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 2028041 7139780 ECED1_2079 Escherichia coli ED1a hypothetical protein YP_002398022.1 2027817 R 585397 CDS YP_002398023.1 218689811 7140900 complement(2028317..2028892) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10722621; Product type h : extrachromosomal origin; hypothetical protein 2028892 7140900 ECED1_2080 Escherichia coli ED1a hypothetical protein YP_002398023.1 2028317 R 585397 CDS YP_002398024.1 218689812 7140901 complement(2028912..2030474) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10722621; Product type h : extrachromosomal origin; putative tail fiber protein from prophage 2030474 7140901 ECED1_2081 Escherichia coli ED1a putative tail fiber protein from prophage YP_002398024.1 2028912 R 585397 CDS YP_002398025.1 218689813 7140902 complement(2030659..2034234) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Host specificity protein J (tail component) from phage origin 2034234 J 7140902 J Escherichia coli ED1a Host specificity protein J (tail component) from phage origin YP_002398025.1 2030659 R 585397 CDS YP_002398026.1 218689814 7142481 complement(2034444..2035124) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail assembly protein I 2035124 7142481 ECED1_2083 Escherichia coli ED1a tail assembly protein I YP_002398026.1 2034444 R 585397 CDS YP_002398027.1 218689815 7140903 complement(2035022..2036026) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail fiber component K 2036026 7140903 ECED1_2084 Escherichia coli ED1a tail fiber component K YP_002398027.1 2035022 R 585397 CDS YP_002398028.1 218689816 7140904 complement(2035776..2036474) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein L 2036474 7140904 ECED1_2085 Escherichia coli ED1a minor tail protein L YP_002398028.1 2035776 R 585397 CDS YP_002398029.1 218689817 7140905 2036460..2036576 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 2036576 7140905 ECED1_2086 Escherichia coli ED1a hypothetical protein YP_002398029.1 2036460 D 585397 CDS YP_002398030.1 218689818 7140906 complement(2036474..2036803) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein M 2036803 7140906 ECED1_2087 Escherichia coli ED1a minor tail protein M YP_002398030.1 2036474 R 585397 CDS YP_002398031.1 218689819 7140907 complement(2036800..2039373) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein H 2039373 7140907 ECED1_2088 Escherichia coli ED1a minor tail protein H YP_002398031.1 2036800 R 585397 CDS YP_002398032.1 218689820 7140908 complement(2039354..2039767) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein T 2039767 7140908 ECED1_2089 Escherichia coli ED1a minor tail protein T YP_002398032.1 2039354 R 585397 CDS YP_002398033.1 218689821 7140909 complement(2039794..2040225) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein G 2040225 7140909 ECED1_2090 Escherichia coli ED1a minor tail protein G YP_002398033.1 2039794 R 585397 CDS YP_002398034.1 218689822 7140910 complement(2040239..2040991) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; major tail protein V 2040991 7140910 ECED1_2091 Escherichia coli ED1a major tail protein V YP_002398034.1 2040239 R 585397 CDS YP_002398035.1 218689823 7140911 complement(2040999..2041394) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein U 2041394 7140911 ECED1_2092 Escherichia coli ED1a minor tail protein U YP_002398035.1 2040999 R 585397 CDS YP_002398036.1 218689824 7140912 complement(2041391..2041966) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein Z (GpZ) 2041966 7140912 ECED1_2093 Escherichia coli ED1a minor tail protein Z (GpZ) YP_002398036.1 2041391 R 585397 CDS YP_002398037.1 218689825 7140913 complement(2041982..2042335) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail attachment protein 2042335 7140913 ECED1_2094 Escherichia coli ED1a tail attachment protein YP_002398037.1 2041982 R 585397 CDS YP_002398038.1 218689826 7140914 complement(2042328..2042759) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2042759 7140914 ECED1_2095 Escherichia coli ED1a hypothetical protein YP_002398038.1 2042328 R 585397 CDS YP_002398039.1 218689827 7140915 complement(2042763..2043791) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; major head protein 2043791 7140915 ECED1_2096 Escherichia coli ED1a major head protein YP_002398039.1 2042763 R 585397 CDS YP_002398040.1 218689828 7140916 complement(2043849..2044196) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; major capsid protein D 2044196 7140916 ECED1_2097 Escherichia coli ED1a major capsid protein D YP_002398040.1 2043849 R 585397 CDS YP_002398041.1 218689829 7140917 complement(2044233..2045738) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; head-tail preconnector protein GP5 2045738 7140917 ECED1_2098 Escherichia coli ED1a head-tail preconnector protein GP5 YP_002398041.1 2044233 R 585397 CDS YP_002398042.1 218689830 7140918 complement(2045728..2047320) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; head protein Gp4 2047320 7140918 ECED1_2099 Escherichia coli ED1a head protein Gp4 YP_002398042.1 2045728 R 585397 CDS YP_002398043.1 218689831 7140919 complement(2047317..2047523) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; head stabilization protein 2047523 7140919 ECED1_2100 Escherichia coli ED1a head stabilization protein YP_002398043.1 2047317 R 585397 CDS YP_002398044.1 218689832 7140920 complement(2047507..2049492) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; terminase large subunit (Gp2) 2049492 7140920 ECED1_2101 Escherichia coli ED1a terminase large subunit (Gp2) YP_002398044.1 2047507 R 585397 CDS YP_002398045.1 218689833 7140921 complement(2049407..2049916) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative terminase small subunit (DNA packaging protein Nu1) from bacteriophage origin 2049916 7140921 ECED1_2102 Escherichia coli ED1a putative terminase small subunit (DNA packaging protein Nu1) from bacteriophage origin YP_002398045.1 2049407 R 585397 CDS YP_002398046.1 218689834 7140922 complement(2050078..2050410) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2050410 7140922 ECED1_2103 Escherichia coli ED1a hypothetical protein YP_002398046.1 2050078 R 585397 CDS YP_002398047.1 218689835 7140923 complement(2050371..2050595) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2050595 7140923 ECED1_2104 Escherichia coli ED1a hypothetical protein YP_002398047.1 2050371 R 585397 CDS YP_002398048.1 218689836 7140924 complement(2050592..2051086) 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Endopeptidase (Lysis protein) from bacteriophage origin 2051086 rz 7140924 rz Escherichia coli ED1a Endopeptidase (Lysis protein) from bacteriophage origin YP_002398048.1 2050592 R 585397 CDS YP_002398049.1 218689837 7141360 complement(2051088..2051261) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2051261 7141360 ECED1_2106 Escherichia coli ED1a hypothetical protein YP_002398049.1 2051088 R 585397 CDS YP_002398050.1 218689838 7140925 complement(2051385..2051918) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-associated lysozyme; Qin prophage 2051918 ydfQ 7140925 ydfQ Escherichia coli ED1a putative membrane-associated lysozyme; Qin prophage YP_002398050.1 2051385 R 585397 CDS YP_002398051.1 218689839 7139267 complement(2052238..2052873) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2052873 7139267 ECED1_2108 Escherichia coli ED1a hypothetical protein YP_002398051.1 2052238 R 585397 CDS YP_002398052.1 218689840 7140926 complement(2052878..2053093) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2019562; Product type pe : putative enzyme; putative phage lysis protein S; DLP12 prophage 2053093 essD 7140926 essD Escherichia coli ED1a putative phage lysis protein S; DLP12 prophage YP_002398052.1 2052878 R 585397 CDS YP_002398053.1 218689841 7139814 complement(2055621..2055911) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2055911 7139814 ECED1_2111 Escherichia coli ED1a hypothetical protein YP_002398053.1 2055621 R 585397 CDS YP_002398054.1 218689842 7140927 complement(2056023..2056430) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative antitermination protein Q 2056430 7140927 ECED1_2112 Escherichia coli ED1a putative antitermination protein Q YP_002398054.1 2056023 R 585397 CDS YP_002398055.1 218689843 7140928 complement(2056433..2057428) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2057428 7140928 ECED1_2113 Escherichia coli ED1a hypothetical protein YP_002398055.1 2056433 R 585397 CDS YP_002398056.1 218689844 7140929 complement(2057430..2058257) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2058257 7140929 ECED1_2114 Escherichia coli ED1a hypothetical protein YP_002398056.1 2057430 R 585397 CDS YP_002398057.1 218689845 7140930 complement(2058408..2058803) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative Crossover junction endodeoxyribonuclease 2058803 7140930 ECED1_2115 Escherichia coli ED1a putative Crossover junction endodeoxyribonuclease YP_002398057.1 2058408 R 585397 CDS YP_002398058.1 218689846 7140931 complement(2058800..2059126) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative LexA repressor 2059126 7140931 ECED1_2116 Escherichia coli ED1a putative LexA repressor YP_002398058.1 2058800 R 585397 CDS YP_002398059.1 218689847 7140932 complement(2059123..2059809) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage AdoMet-dependent methyltransferase 2059809 7140932 ECED1_2117 Escherichia coli ED1a putative phage AdoMet-dependent methyltransferase YP_002398059.1 2059123 R 585397 CDS YP_002398060.1 218689848 7140933 complement(2059776..2060270) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2060270 yfdN 7140933 yfdN Escherichia coli ED1a hypothetical protein YP_002398060.1 2059776 R 585397 CDS YP_002398061.1 218689849 7144012 complement(2060267..2061250) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative replication protein from phage (modular protein) 2061250 7144012 ECED1_2119 Escherichia coli ED1a putative replication protein from phage (modular protein) YP_002398061.1 2060267 R 585397 CDS YP_002398062.1 218689850 7140934 complement(2061247..2061546) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 2061546 7140934 ECED1_2120 Escherichia coli ED1a hypothetical protein YP_002398062.1 2061247 R 585397 CDS YP_002398063.1 218689851 7140935 complement(2061543..2061767) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2061767 7140935 ECED1_2121 Escherichia coli ED1a hypothetical protein YP_002398063.1 2061543 R 585397 CDS YP_002398064.1 218689852 7140936 complement(2061764..2062927) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2062927 7140936 ECED1_2122 Escherichia coli ED1a hypothetical protein YP_002398064.1 2061764 R 585397 CDS YP_002398065.1 218689853 7140937 complement(2062924..2063481) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative nucleic acid-binding protein; e14 prophage 2063481 ymfL 7140937 ymfL Escherichia coli ED1a putative nucleic acid-binding protein; e14 prophage YP_002398065.1 2062924 R 585397 CDS YP_002398066.1 218689854 7140980 complement(2063474..2063734) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative lambda repressor-like DNA-binding domains 2063734 7140980 ECED1_2125 Escherichia coli ED1a putative lambda repressor-like DNA-binding domains YP_002398066.1 2063474 R 585397 CDS YP_002398067.1 218689855 7140938 2063832..2064524 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative repressor protein CI 2064524 7140938 ECED1_2126 Escherichia coli ED1a putative repressor protein CI YP_002398067.1 2063832 D 585397 CDS YP_002398068.1 218689856 7141100 2065084..2066151 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 2066151 7141100 ECED1_2127 Escherichia coli ED1a hypothetical protein YP_002398068.1 2065084 D 585397 CDS YP_002398069.1 218689857 7142743 2066242..2066778 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2066778 yfdR 7142743 yfdR Escherichia coli ED1a hypothetical protein YP_002398069.1 2066242 D 585397 CDS YP_002398070.1 218689858 7144013 2066769..2067380 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2067380 7144013 ECED1_2129 Escherichia coli ED1a hypothetical protein YP_002398070.1 2066769 D 585397 CDS YP_002398071.1 218689859 7139999 2067344..2067601 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2067601 7139999 ECED1_2130 Escherichia coli ED1a hypothetical protein YP_002398071.1 2067344 D 585397 CDS YP_002398072.1 218689860 7140000 2067598..2068293 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; putative EA22-like protein 2068293 7140000 ECED1_2131 Escherichia coli ED1a putative EA22-like protein YP_002398072.1 2067598 D 585397 CDS YP_002398073.1 218689861 7140001 2068214..2068867 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2068867 7140001 ECED1_2132 Escherichia coli ED1a hypothetical protein YP_002398073.1 2068214 D 585397 CDS YP_002398074.1 218689862 7140002 2068916..2069194 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2069194 7140002 ECED1_2133 Escherichia coli ED1a hypothetical protein YP_002398074.1 2068916 D 585397 CDS YP_002398075.1 218689863 7140003 2069198..2069344 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2069344 7140003 ECED1_2134 Escherichia coli ED1a hypothetical protein YP_002398075.1 2069198 D 585397 CDS YP_002398076.1 218689864 7140004 2069353..2069589 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative excisionase 2069589 7140004 ECED1_2135 Escherichia coli ED1a putative excisionase YP_002398076.1 2069353 D 585397 CDS YP_002398077.1 218689865 7140005 2069645..2070958 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; integrase 2070958 int 7140005 int Escherichia coli ED1a integrase YP_002398077.1 2069645 D 585397 CDS YP_002398078.1 218689866 7141176 2070985..2071710 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2129559, 7984428; hypothetical protein 2071710 yecE 7141176 yecE Escherichia coli ED1a hypothetical protein YP_002398078.1 2070985 D 585397 CDS YP_002398079.1 218689867 7140534 2071763..2072158 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2072158 yecN 7140534 yecN Escherichia coli ED1a hypothetical protein YP_002398079.1 2071763 D 585397 CDS YP_002398080.1 218689868 7140541 2072199..2072942 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11746687; Product type e : enzyme; AdoMet-dependent methyltransferase 2072942 yecO 7140541 yecO Escherichia coli ED1a AdoMet-dependent methyltransferase YP_002398080.1 2072199 D 585397 CDS YP_002398081.1 218689869 7140542 2072939..2073910 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2073910 yecP 7140542 yecP Escherichia coli ED1a hypothetical protein YP_002398081.1 2072939 D 585397 CDS YP_002398082.1 218689870 7140543 complement(2073946..2076375) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 97077292, 11004177; Product type e : enzyme; trimethylamine N-oxide reductase system III, catalytic subunit 2076375 torZ 7140543 torZ Escherichia coli ED1a trimethylamine N-oxide reductase system III, catalytic subunit YP_002398082.1 2073946 R 585397 CDS YP_002398083.1 218689871 7140799 complement(2076400..2077500) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20461225, 8919859; Product type c : carrier; TMAO reductase III (TorYZ), cytochrome c-type subunit 2077500 torY 7140799 torY Escherichia coli ED1a TMAO reductase III (TorYZ), cytochrome c-type subunit YP_002398083.1 2076400 R 585397 CDS YP_002398084.1 218689872 7140798 complement(2077888..2078634) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95362641, 7635807; Product type t : transporter; copper homeostasis protein CutC 2078634 cutC 7140798 cutC Escherichia coli ED1a copper homeostasis protein CutC YP_002398084.1 2077888 R 585397 CDS YP_002398085.1 218689873 7142090 complement(2078648..2079214) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12660999; Product type pe : putative enzyme; hypothetical protein 2079214 yecM 7142090 yecM Escherichia coli ED1a hypothetical protein YP_002398085.1 2078648 R 585397 CDS YP_002398086.1 218689874 7140540 2079430..2081163 1 NC_011745.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 2081163 argS 7140540 argS Escherichia coli ED1a arginyl-tRNA synthetase YP_002398086.1 2079430 D 585397 CDS YP_002398087.1 218689875 7142620 complement(2081216..2081608) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8002587, 1482109, 89181349; hypothetical protein 2081608 flhE 7142620 flhE Escherichia coli ED1a hypothetical protein YP_002398087.1 2081216 R 585397 CDS YP_002398088.1 218689876 7142128 complement(2081608..2083686) 1 NC_011745.1 membrane protein involved in the flagellar export apparatus; flagellar biosynthesis protein FlhA 2083686 flhA 7142128 flhA Escherichia coli ED1a flagellar biosynthesis protein FlhA YP_002398088.1 2081608 R 585397 CDS YP_002398089.1 218689877 7142124 complement(2083679..2084827) 1 NC_011745.1 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export; flagellar biosynthesis protein FlhB 2084827 flhB 7142124 flhB Escherichia coli ED1a flagellar biosynthesis protein FlhB YP_002398089.1 2083679 R 585397 CDS YP_002398090.1 218689878 7142125 complement(2085016..2085660) 1 NC_011745.1 cytosolic phosphatase which functions in the chemotaxis signal transduction complex by controlling the level of phosphorylated CheY through dephosphorylation; chemotaxis regulator CheZ 2085660 cheZ 7142125 cheZ Escherichia coli ED1a chemotaxis regulator CheZ YP_002398090.1 2085016 R 585397 CDS YP_002398091.1 218689879 7139343 complement(2085671..2086060) 1 NC_011745.1 chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble; chemotaxis regulatory protein CheY 2086060 cheY 7139343 cheY Escherichia coli ED1a chemotaxis regulatory protein CheY YP_002398091.1 2085671 R 585397 CDS YP_002398092.1 218689880 7139342 complement(2086075..2087124) 1 NC_011745.1 regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins; chemotaxis-specific methylesterase 2087124 cheB 7139342 cheB Escherichia coli ED1a chemotaxis-specific methylesterase YP_002398092.1 2086075 R 585397 CDS YP_002398093.1 218689881 7139339 complement(2087127..2087987) 1 NC_011745.1 methylates the MCP; chemotaxis methyltransferase CheR 2087987 cheR 7139339 cheR Escherichia coli ED1a chemotaxis methyltransferase CheR YP_002398093.1 2087127 R 585397 CDS YP_002398094.1 218689882 7141509 complement(2088278..2089939) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90094243, 92165727, 6305515, 9315712; Product type r : regulator; methyl-accepting chemotaxis protein II 2089939 tar 7141509 tar Escherichia coli ED1a methyl-accepting chemotaxis protein II YP_002398094.1 2088278 R 585397 CDS YP_002398095.1 218689883 7140754 complement(2090084..2090587) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91126073, 91296802, 91317710, 2002011, 3510184; Product type r : regulator; purine-binding chemotaxis protein 2090587 cheW 7140754 cheW Escherichia coli ED1a purine-binding chemotaxis protein YP_002398095.1 2090084 R 585397 CDS YP_002398096.1 218689884 7139341 complement(2090608..2092572) 1 NC_011745.1 chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY; sensory histidine kinase/signal sensing protein; CheA is the histidine kinase component; chemotaxis protein CheA 2092572 cheA 7139341 cheA Escherichia coli ED1a chemotaxis protein CheA YP_002398096.1 2090608 R 585397 CDS YP_002398097.1 218689885 7139338 complement(2092577..2093503) 1 NC_011745.1 with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotB 2093503 motB 7139338 motB Escherichia coli ED1a flagellar motor protein MotB YP_002398097.1 2092577 R 585397 CDS YP_002398098.1 218689886 7139013 complement(2093500..2094387) 1 NC_011745.1 With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotA 2094387 motA 7139013 motA Escherichia coli ED1a flagellar motor protein MotA YP_002398098.1 2093500 R 585397 CDS YP_002398099.1 218689887 7139012 complement(2094514..2095092) 1 NC_011745.1 With FlhD is involved in the activation of class 2 flagellar genes and as well as a number of other genetic systems; transcriptional activator FlhC 2095092 flhC 7139012 flhC Escherichia coli ED1a transcriptional activator FlhC YP_002398099.1 2094514 R 585397 CDS YP_002398100.1 218689888 7142126 complement(2095095..2095454) 1 NC_011745.1 with FlhC is involved in the activation of class 2 flagellar genes and is involved in the regulation of a number of other genetic systems; transcriptional activator FlhD 2095454 flhD 7142126 flhD Escherichia coli ED1a transcriptional activator FlhD YP_002398100.1 2095095 R 585397 CDS YP_002398101.1 218689889 7142127 2096225..2096653 1 NC_011745.1 ppGpp-dependent; membrane-associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress; universal stress protein UspC 2096653 yecG 7142127 yecG Escherichia coli ED1a universal stress protein UspC YP_002398101.1 2096225 D 585397 CDS YP_002398102.1 218689890 7140536 complement(2096660..2098084) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92078100, 92121128, 93302496, 8045430; Product type e : enzyme; trehalose-6-phosphate synthase 2098084 otsA 7140536 otsA Escherichia coli ED1a trehalose-6-phosphate synthase YP_002398102.1 2096660 R 585397 CDS YP_002398103.1 218689891 7139991 complement(2098059..2098859) 1 NC_011745.1 biosynthetic; catalyzes the formation of trehalose and phosphate from trehalose-6-phosphate; expression is increased under osmotic stress and induced during the transition to stationary phase and by decreased temperature; trehalose-6-phosphate phosphatase 2098859 otsB 7139991 otsB Escherichia coli ED1a trehalose-6-phosphate phosphatase YP_002398103.1 2098059 R 585397 CDS YP_002398104.1 218689892 7139992 complement(2099026..2100015) 1 NC_011745.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose transporter permease 2100015 araH 7139992 araH Escherichia coli ED1a L-arabinose transporter permease YP_002398104.1 2099026 R 585397 CDS YP_002398105.1 218689893 7142603 complement(2100027..2101541) 1 NC_011745.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose transporter ATP-binding protein 2101541 araG 7142603 araG Escherichia coli ED1a L-arabinose transporter ATP-binding protein YP_002398105.1 2100027 R 585397 CDS YP_002398106.1 218689894 7142602 complement(2101611..2102645) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89255061, 90375534, 2445996, 326784, 326785, 6885805, 7031057, 9298646; Product type t : transporter; L-arabinose ABC transporter subunit periplasmic-binding protein 2102645 araF 7142602 araF Escherichia coli ED1a L-arabinose ABC transporter subunit periplasmic-binding protein YP_002398106.1 2101611 R 585397 CDS YP_002398107.1 218689895 7142601 complement(2103261..2103764) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 2103764 insB 7142601 insB Escherichia coli ED1a IS1 transposase InsAB' YP_002398107.1 2103261 R 585397 CDS YP_002398108.1 218689896 7141143 complement(2103683..2103958) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; Transposase ORF A, IS1 2103958 insA 7141143 insA Escherichia coli ED1a Transposase ORF A, IS1 YP_002398108.1 2103683 R 585397 CDS YP_002398109.1 218689897 7141121 2104168..2104671 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative ferritin-like protein 2104671 yecI 7141121 yecI Escherichia coli ED1a putative ferritin-like protein YP_002398109.1 2104168 D 585397 CDS YP_002398110.1 218689898 7140538 complement(2104750..2105001) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2105001 yecJ 7140538 yecJ Escherichia coli ED1a hypothetical protein YP_002398110.1 2104750 R 585397 CDS YP_002398111.1 218689899 7140755 2105113..2105259 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2105259 7140755 ECED1_2171 Escherichia coli ED1a hypothetical protein YP_002398111.1 2105113 D 585397 CDS YP_002398112.1 218689900 7140006 2105465..2105788 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2105788 yecR 7140006 yecR Escherichia coli ED1a hypothetical protein YP_002398112.1 2105465 D 585397 CDS YP_002398113.1 218689901 7140544 2105959..2106456 1 NC_011745.1 cytoplasmic iron storage protein; ferritin 2106456 ftn 7140544 ftn Escherichia coli ED1a ferritin YP_002398113.1 2105959 D 585397 CDS YP_002398114.1 218689902 7142187 complement(2106494..2106733) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2106733 yecH 7142187 yecH Escherichia coli ED1a hypothetical protein YP_002398114.1 2106494 R 585397 CDS YP_002398115.1 218689903 7140537 2106924..2108135 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89008121, 2022620; Product type t : transporter; tyrosine transporter 2108135 tyrP 7140537 tyrP Escherichia coli ED1a tyrosine transporter YP_002398115.1 2106924 D 585397 CDS YP_002398116.1 218689904 7140852 complement(2108197..2108862) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2108862 yecA 7140852 yecA Escherichia coli ED1a hypothetical protein YP_002398116.1 2108197 R 585397 CDS YP_002398117.1 218689905 7140624 complement(2109512..2110060) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 381294, 7007311, 94253011, 1323047, 3003065, 8917447; Product type e : enzyme; phosphatidylglycerophosphate synthetase 2110060 pgsA 7140624 pgsA Escherichia coli ED1a phosphatidylglycerophosphate synthetase YP_002398117.1 2109512 R 585397 CDS YP_002398118.1 218689906 7144080 complement(2110117..2111949) 1 NC_011745.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 2111949 uvrC 7144080 uvrC Escherichia coli ED1a excinuclease ABC subunit C YP_002398118.1 2110117 R 585397 CDS YP_002398119.1 218689907 7139152 complement(2111946..2112602) 1 NC_011745.1 in Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system; in Salmonella SirA and BarA regulate virulence gene expression also via the Csr system; response regulator 2112602 uvrY 7139152 uvrY Escherichia coli ED1a response regulator YP_002398119.1 2111946 R 585397 CDS YP_002398120.1 218689908 7139154 2113061..2113285 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3515318, 7567469; hypothetical protein 2113285 yecF 7139154 yecF Escherichia coli ED1a hypothetical protein YP_002398120.1 2113061 D 585397 CDS YP_002398121.1 218689909 7140535 complement(2113353..2114075) 1 NC_011745.1 regulates genes involved in cell division; DNA-binding transcriptional activator SdiA 2114075 sdiA 7140535 sdiA Escherichia coli ED1a DNA-binding transcriptional activator SdiA YP_002398121.1 2113353 R 585397 CDS YP_002398122.1 218689910 7141384 complement(2114305..2115057) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative amino-acid ABC transporter ATP-binding protein YecC 2115057 yecC 7141384 yecC Escherichia coli ED1a putative amino-acid ABC transporter ATP-binding protein YecC YP_002398122.1 2114305 R 585397 CDS YP_002398123.1 218689911 7141702 complement(2115054..2115722) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter permease 2115722 yecS 7141702 yecS Escherichia coli ED1a putative ABC transporter permease YP_002398123.1 2115054 R 585397 CDS YP_002398124.1 218689912 7140545 complement(2115737..2116723) 1 NC_011745.1 catalyzes the formation of pyruvate from D-cysteine; D-cysteine desulfhydrase 2116723 yedO 7140545 yedO Escherichia coli ED1a D-cysteine desulfhydrase YP_002398124.1 2115737 R 585397 CDS YP_002398125.1 218689913 7140553 complement(2116828..2117628) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96125225, 8450713, 8774726, 9298646, 9740056; Product type t : transporter; cystine transporter subunit 2117628 fliY 7140553 fliY Escherichia coli ED1a cystine transporter subunit YP_002398125.1 2116828 R 585397 CDS YP_002398126.1 218689914 7142148 complement(2117716..2118267) 1 NC_011745.1 expression activator of the class 2 type of flagellar operons, essential to achieve maximal cell motility; activator of type 1 fimbrial gene expression; cell density-responsive regulator; FliZ in Salmonella typhimurium induces HilA, an activator of invasion genes necessary to achieve full virulence; flagella biosynthesis protein FliZ 2118267 fliZ 7142148 fliZ Escherichia coli ED1a flagella biosynthesis protein FliZ YP_002398126.1 2117716 R 585397 CDS YP_002398127.1 218689915 7142149 complement(2118313..2119032) 1 NC_011745.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes; flagellar biosynthesis sigma factor 2119032 fliA 7142149 fliA Escherichia coli ED1a flagellar biosynthesis sigma factor YP_002398127.1 2118313 R 585397 CDS YP_002398128.1 218689916 7142129 complement(2119197..2120657) 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7690024; Product type s : structure; Flagellin (Phase 1-C flagellin) 2120657 fliC 7142129 fliC Escherichia coli ED1a Flagellin (Phase 1-C flagellin) YP_002398128.1 2119197 R 585397 CDS YP_002398129.1 218689917 7142130 2120834..2122324 1 NC_011745.1 involved in flagellin assembly; flagellar capping protein 2122324 fliD 7142130 fliD Escherichia coli ED1a flagellar capping protein YP_002398129.1 2120834 D 585397 CDS YP_002398130.1 218689918 7142131 2122339..2122749 1 NC_011745.1 flagellin specific chaperone; flagellar protein FliS 2122749 fliS 7142131 fliS Escherichia coli ED1a flagellar protein FliS YP_002398130.1 2122339 D 585397 CDS YP_002398131.1 218689919 7142146 2122749..2123114 1 NC_011745.1 binds flagellar cap subunits (FliD) and seems to prevents their oligomerization prior to its translocation through the flagellum-specific type III export pathway; acts as a repressor of flagellar class 2 operons by preventing FlhD2C2 to bind the promoter and inhibiting the FlhD2C2-dependent transcription; member of the type III cytoplasmic chaperone family; flagellar biosynthesis protein FliT 2123114 fliT 7142146 fliT Escherichia coli ED1a flagellar biosynthesis protein FliT YP_002398131.1 2122749 D 585397 CDS YP_002398132.1 218689920 7142147 2123192..2124679 1 NC_011745.1 converts 1,4-alpha-D-glucans to maltodextrin; cytoplasmic alpha-amylase 2124679 amyA 7142147 amyA Escherichia coli ED1a cytoplasmic alpha-amylase YP_002398132.1 2123192 D 585397 CDS YP_002398133.1 218689921 7142581 complement(2124713..2125126) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2125126 yedD 7142581 yedD Escherichia coli ED1a hypothetical protein YP_002398133.1 2124713 R 585397 CDS YP_002398134.1 218689922 7140547 2125313..2126518 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; putative inner membrane protein 2126518 yedE 7140547 yedE Escherichia coli ED1a putative inner membrane protein YP_002398134.1 2125313 D 585397 CDS YP_002398135.1 218689923 7140548 2126515..2126748 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2126748 yedF 7140548 yedF Escherichia coli ED1a hypothetical protein YP_002398135.1 2126515 D 585397 CDS YP_002398136.1 218689924 7140549 2126855..2127526 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2127526 yedK 7140549 yedK Escherichia coli ED1a hypothetical protein YP_002398136.1 2126855 D 585397 CDS YP_002398137.1 218689925 7140552 complement(2127566..2128774) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transposase 2128774 ydcM 7140552 ydcM Escherichia coli ED1a putative transposase YP_002398137.1 2127566 R 585397 CDS YP_002398138.1 218689926 7139228 complement(2128752..2128898) 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 2128898 7139228 ECED1_2198 Escherichia coli ED1a hypothetical protein YP_002398138.1 2128752 R 585397 CDS YP_002398139.1 218689927 7140007 2128782..2129069 1 NC_011745.1 Evidence 7 : Gene remnant; hypothetical protein 2129069 yncK 7140007 yncK Escherichia coli ED1a hypothetical protein YP_002398139.1 2128782 D 585397 CDS YP_002398140.1 218689928 7141000 complement(2129788..2129961) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2129961 7141000 ECED1_2200 Escherichia coli ED1a hypothetical protein YP_002398140.1 2129788 R 585397 CDS YP_002398141.1 218689929 7140008 complement(2130161..2130862) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12270809; Product type pr : putative regulator; putative DNA-binding transcriptional regulator; DLP12 prophage 2130862 ybcM 7140008 ybcM Escherichia coli ED1a putative DNA-binding transcriptional regulator; DLP12 prophage YP_002398141.1 2130161 R 585397 CDS YP_002398142.1 218689930 7138921 complement(2130967..2131518) 1 NC_011745.1 DLP12 prophage; similar to PEBP/RK1P protein family in eukaryotes that inhibits MEK phosphorylation by Raf-1; crystal structure suggests similar properties but exact function is unknown; putative kinase inhibitor 2131518 ybcL 7138921 ybcL Escherichia coli ED1a putative kinase inhibitor YP_002398142.1 2130967 R 585397 CDS YP_002398143.1 218689931 7138920 complement(2131687..2132199) 1 NC_011745.1 member of the small MDR (multidrug resistance) family of transporters; in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin; proton-dependent secondary transporter which exchanges protons for compound translocation; multidrug efflux protein 2132199 emrE 7138920 emrE Escherichia coli ED1a multidrug efflux protein YP_002398143.1 2131687 R 585397 CDS YP_002398144.1 218689932 7139788 complement(2132353..2132667) 1 NC_011745.1 forms a junction between the M-ring and FlgB during flagella biosynthesis; flagellar hook-basal body protein FliE 2132667 fliE 7139788 fliE Escherichia coli ED1a flagellar hook-basal body protein FliE YP_002398144.1 2132353 R 585397 CDS YP_002398145.1 218689933 7142132 2132882..2134540 1 NC_011745.1 the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod; flagellar MS-ring protein 2134540 fliF 7142132 fliF Escherichia coli ED1a flagellar MS-ring protein YP_002398145.1 2132882 D 585397 CDS YP_002398146.1 218689934 7142133 2134533..2135528 1 NC_011745.1 One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein G 2135528 fliG 7142133 fliG Escherichia coli ED1a flagellar motor switch protein G YP_002398146.1 2134533 D 585397 CDS YP_002398147.1 218689935 7142134 2135521..2136207 1 NC_011745.1 binds to and inhibits the function of flagella specific ATPase FliI; flagellar assembly protein H 2136207 fliH 7142134 fliH Escherichia coli ED1a flagellar assembly protein H YP_002398147.1 2135521 D 585397 CDS YP_002398148.1 218689936 7142135 2136207..2137580 1 NC_011745.1 involved in type III protein export during flagellum assembly; flagellum-specific ATP synthase 2137580 fliI 7142135 fliI Escherichia coli ED1a flagellum-specific ATP synthase YP_002398148.1 2136207 D 585397 CDS YP_002398149.1 218689937 7142136 2137599..2138042 1 NC_011745.1 rod/hook and filament chaperone; flagellar biosynthesis chaperone 2138042 fliJ 7142136 fliJ Escherichia coli ED1a flagellar biosynthesis chaperone YP_002398149.1 2137599 D 585397 CDS YP_002398150.1 218689938 7142137 2138039..2139166 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1482109, 8631687; Product type s : structure; flagellar hook-length control protein 2139166 fliK 7142137 fliK Escherichia coli ED1a flagellar hook-length control protein YP_002398150.1 2138039 D 585397 CDS YP_002398151.1 218689939 7142138 2139271..2139735 1 NC_011745.1 interacts with cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring; flagellar basal body-associated protein FliL 2139735 fliL 7142138 fliL Escherichia coli ED1a flagellar basal body-associated protein FliL YP_002398151.1 2139271 D 585397 CDS YP_002398152.1 218689940 7142139 2139740..2140744 1 NC_011745.1 with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation; flagellar motor switch protein FliM 2140744 fliM 7142139 fliM Escherichia coli ED1a flagellar motor switch protein FliM YP_002398152.1 2139740 D 585397 CDS YP_002398153.1 218689941 7142140 2140741..2141154 1 NC_011745.1 One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein FliN 2141154 fliN 7142140 fliN Escherichia coli ED1a flagellar motor switch protein FliN YP_002398153.1 2140741 D 585397 CDS YP_002398154.1 218689942 7142141 2141157..2141522 1 NC_011745.1 with FlhA, FlhB, FliP, FliQ and FliR is one of the membrane components of the flagellar export apparatus; flagellar biosynthesis protein FliO 2141522 fliO 7142141 fliO Escherichia coli ED1a flagellar biosynthesis protein FliO YP_002398154.1 2141157 D 585397 CDS YP_002398155.1 218689943 7142142 2141522..2142259 1 NC_011745.1 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliP 2142259 fliP 7142142 fliP Escherichia coli ED1a flagellar biosynthesis protein FliP YP_002398155.1 2141522 D 585397 CDS YP_002398156.1 218689944 7142143 2142269..2142538 1 NC_011745.1 with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliQ 2142538 fliQ 7142143 fliQ Escherichia coli ED1a flagellar biosynthesis protein FliQ YP_002398156.1 2142269 D 585397 CDS YP_002398157.1 218689945 7142144 2142546..2143331 1 NC_011745.1 FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliR 2143331 fliR 7142144 fliR Escherichia coli ED1a flagellar biosynthesis protein FliR YP_002398157.1 2142546 D 585397 CDS YP_002398158.1 218689946 7142145 2143621..2144244 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14514676, 14766922, 20167175, 90130299, 91154130, 92048476, 9882673, 7534408; Product type r : regulator; DNA-binding transcriptional activator, co-regulator with RcsB 2144244 rcsA 7142145 rcsA Escherichia coli ED1a DNA-binding transcriptional activator, co-regulator with RcsB YP_002398158.1 2143621 D 585397 CDS YP_002398159.1 218689947 7141263 complement(2144288..2144476) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 96324407, 7534408; hypothetical protein 2144476 dsrB 7141263 dsrB Escherichia coli ED1a hypothetical protein YP_002398159.1 2144288 R 585397 CDS YP_002398160.1 218689948 7140530 2144639..2144866 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2144866 yodD 7140530 yodD Escherichia coli ED1a hypothetical protein YP_002398160.1 2144639 D 585397 CDS YP_002398161.1 218689949 7140528 2145164..2145979 1 NC_011745.1 catalyzes the hydrolysis of mannosyl-3-phosphoglycerate to form the osmolyte mannosylglycerate; mannosyl-3-phosphoglycerate phosphatase 2145979 yedP 7140528 yedP Escherichia coli ED1a mannosyl-3-phosphoglycerate phosphatase YP_002398161.1 2145164 D 585397 CDS YP_002398162.1 218689950 7140554 complement(2145976..2147670) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16530465; Product type pe : putative enzyme; putative diguanylate cyclase 2147670 yedQ 7140554 yedQ Escherichia coli ED1a putative diguanylate cyclase YP_002398162.1 2145976 R 585397 CDS YP_002398163.1 218689951 7140555 complement(2147591..2147779) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2147779 7140555 ECED1_2223 Escherichia coli ED1a hypothetical protein YP_002398163.1 2147591 R 585397 CDS YP_002398164.1 218689952 7140009 complement(2147841..2148023) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2148023 yodC 7140009 yodC Escherichia coli ED1a hypothetical protein YP_002398164.1 2147841 R 585397 CDS YP_002398165.1 218689953 7140264 complement(2148102..2149019) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2149019 yedI 7140264 yedI Escherichia coli ED1a hypothetical protein YP_002398165.1 2148102 R 585397 CDS YP_002398166.1 218689954 7140550 2149192..2150112 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2150112 yedA 7140550 yedA Escherichia coli ED1a hypothetical protein YP_002398166.1 2149192 D 585397 CDS YP_002398167.1 218689955 7140546 complement(2150101..2150571) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90330522, 92049708, 94049122, 10360178, 10612397, 10871403, 2527357; Product type e : enzyme; DNA mismatch endonuclease of very short patch repair 2150571 vsr 7140546 vsr Escherichia coli ED1a DNA mismatch endonuclease of very short patch repair YP_002398167.1 2150101 R 585397 CDS YP_002398168.1 218689956 7139168 complement(2150552..2151970) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90280700, 91285397, 93367813, 2198248, 2527357; Product type e : enzyme; DNA cytosine methylase 2151970 dcm 7139168 dcm Escherichia coli ED1a DNA cytosine methylase YP_002398168.1 2150552 R 585397 CDS YP_002398169.1 218689957 7143069 complement(2152037..2152732) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7567469; Product type pe : putative enzyme; hypothetical protein 2152732 yedJ 7143069 yedJ Escherichia coli ED1a hypothetical protein YP_002398169.1 2152037 R 585397 CDS YP_002398170.1 218689958 7140551 complement(2152772..2153137) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2153137 yedR 7140551 yedR Escherichia coli ED1a hypothetical protein YP_002398170.1 2152772 R 585397 CDS YP_002398171.1 218689959 7140112 2153633..2154775 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pm : putative membrane component; outer membrane protein F 2154775 7140112 ECED1_2231 Escherichia coli ED1a outer membrane protein F YP_002398171.1 2153633 D 585397 CDS YP_002398172.1 218689960 7140010 2155367..2156218 1 NC_011745.1 Hsp31 stabilizes early unfolding protein intermediates under severe heat stress; chaperone protein HchA 2156218 hchA 7140010 hchA Escherichia coli ED1a chaperone protein HchA YP_002398172.1 2155367 D 585397 CDS YP_002398173.1 218689961 7139855 complement(2156326..2157684) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15522865; Product type rc : receptor; sensory kinase in two-component regulatory system with YedW 2157684 yedV 7139855 yedV Escherichia coli ED1a sensory kinase in two-component regulatory system with YedW YP_002398173.1 2156326 R 585397 CDS YP_002398174.1 218689962 7140557 complement(2157684..2158355) 1 NC_011745.1 induced by CusR in the presence of copper; YedW induces the expression of the upstream gene yedV (encoding a sensor kinase) as well as yedW; yedVW is one of four copper regulons found in E. coli; part of the copper homeostasis mechanism; confers resistance to copper and several drugs when induced; transcriptional regulatory protein YedW 2158355 yedW 7140557 yedW Escherichia coli ED1a transcriptional regulatory protein YedW YP_002398174.1 2157684 R 585397 CDS YP_002398175.1 218689963 7140558 2158488..2158901 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2158901 yedX 7140558 yedX Escherichia coli ED1a hypothetical protein YP_002398175.1 2158488 D 585397 CDS YP_002398176.1 218689964 7140559 2159010..2160014 1 NC_011745.1 in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ; putative sulfite oxidase subunit YedY 2160014 yedY 7140559 yedY Escherichia coli ED1a putative sulfite oxidase subunit YedY YP_002398176.1 2159010 D 585397 CDS YP_002398177.1 218689965 7140560 2160015..2160650 1 NC_011745.1 in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme; putative sulfite oxidase subunit YedZ 2160650 yedZ 7140560 yedZ Escherichia coli ED1a putative sulfite oxidase subunit YedZ YP_002398177.1 2160015 D 585397 CDS YP_002398178.1 218689966 7140561 2160907..2161557 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12077457, 12480884, 12909634, 9579078; hypothetical protein 2161557 yodA 7140561 yodA Escherichia coli ED1a hypothetical protein YP_002398178.1 2160907 D 585397 CDS YP_002398179.1 218689967 7140262 2161667..2161816 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2161816 7140262 ECED1_2239 Escherichia coli ED1a hypothetical protein YP_002398179.1 2161667 D 585397 CDS YP_002398180.1 218689968 7140011 2161900..2162430 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16042411; Product type pc : putative carrier; putative cytochrome 2162430 yodB 7140011 yodB Escherichia coli ED1a putative cytochrome YP_002398180.1 2161900 D 585397 CDS YP_002398181.1 218689969 7140623 2163183..2163980 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2163980 yeeI 7140623 yeeI Escherichia coli ED1a hypothetical protein YP_002398181.1 2163183 D 585397 CDS YP_002398182.1 218689970 7140787 2164318..2165580 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; integrase 2165580 int 7140787 int Escherichia coli ED1a integrase YP_002398182.1 2164318 D 585397 CDS YP_002398183.1 218689971 7141177 complement(2165774..2167078) 1 NC_011745.1 catalyzes the conversion of chorismate to salicylate in the biosynthesis of the siderophore yersiniabactin; salicylate synthase Irp9 2167078 irp 7141177 irp Escherichia coli ED1a salicylate synthase Irp9 YP_002398183.1 2165774 R 585397 CDS YP_002398184.1 218689972 7142448 complement(2167106..2168509) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; yersiniabactin-iron transporter permease YbtX 2168509 irp 7142448 irp Escherichia coli ED1a yersiniabactin-iron transporter permease YbtX YP_002398184.1 2167106 R 585397 CDS YP_002398185.1 218689973 7142449 complement(2168379..2170208) 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10231486, 11320115; Product type t : transporter; yersiniabactin-iron ABC transporter permease ATP-binding protein YbtQ 2170208 irp 7142449 irp Escherichia coli ED1a yersiniabactin-iron ABC transporter permease ATP-binding protein YbtQ YP_002398185.1 2168379 R 585397 CDS YP_002398186.1 218689974 7142450 complement(2170168..2171970) 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10231486, 11320115; Product type t : transporter; yersiniabactin-iron ABC transporter permease ATP-binding protein YbtP 2171970 irp 7142450 irp Escherichia coli ED1a yersiniabactin-iron ABC transporter permease ATP-binding protein YbtP YP_002398186.1 2170168 R 585397 CDS YP_002398187.1 218689975 7142451 2172137..2173096 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8930916; Product type r : regulator; AraC family transcriptional regulator 2173096 ybtA 7142451 ybtA Escherichia coli ED1a AraC family transcriptional regulator YP_002398187.1 2172137 D 585397 CDS YP_002398188.1 218689976 7142698 2173269..2179394 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15719346, 15582399, 8366034, 11927258, 9709002; Product type e : enzyme; High-molecular-weight nonribosomal peptide/polyketide synthetase 2 2179394 irp 7142698 irp Escherichia coli ED1a High-molecular-weight nonribosomal peptide/polyketide synthetase 2 YP_002398188.1 2173269 D 585397 CDS YP_002398189.1 218689977 7142452 2179482..2188973 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15719346, 15582399, 11927258; Product type e : enzyme; High-molecular-weight nonribosomal peptide/polyketide synthetase 1 2188973 irp 7142452 irp Escherichia coli ED1a High-molecular-weight nonribosomal peptide/polyketide synthetase 1 YP_002398189.1 2179482 D 585397 CDS YP_002398190.1 218689978 7142453 2188910..2190070 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11927258; Product type e : enzyme; Thiazolinyl-S-HMWP1 reductase YbtU 2190070 irp 7142453 irp Escherichia coli ED1a Thiazolinyl-S-HMWP1 reductase YbtU YP_002398190.1 2188910 D 585397 CDS YP_002398191.1 218689979 7142454 2190067..2190870 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative thioesterase YbtT 2190870 irp 7142454 irp Escherichia coli ED1a putative thioesterase YbtT YP_002398191.1 2190067 D 585397 CDS YP_002398192.1 218689980 7142455 2190874..2192451 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9818149, 11927258, 9709002; Product type e : enzyme; salicyl-AMP ligase YbtE 2192451 irp 7142455 irp Escherichia coli ED1a salicyl-AMP ligase YbtE YP_002398192.1 2190874 D 585397 CDS YP_002398193.1 218689981 7142456 2192582..2194603 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7896707, 7984105; Product type rc : receptor; yersiniabactin/pesticin outer membrane receptor (IRPC) 2194603 fyuA 7142456 fyuA Escherichia coli ED1a yersiniabactin/pesticin outer membrane receptor (IRPC) YP_002398193.1 2192582 D 585397 CDS YP_002398194.1 218689982 7143137 2195417..2196400 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2196400 7143137 ECED1_2255 Escherichia coli ED1a hypothetical protein YP_002398194.1 2195417 D 585397 CDS YP_002398195.1 218689983 7140012 2196744..2196929 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2196929 7140012 ECED1_2256 Escherichia coli ED1a hypothetical protein YP_002398195.1 2196744 D 585397 CDS YP_002398196.1 218689984 7140013 2196914..2197495 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2197495 7140013 ECED1_2257 Escherichia coli ED1a hypothetical protein YP_002398196.1 2196914 D 585397 CDS YP_002398197.1 218689985 7140014 2197485..2197694 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative lambdoid prophage protein from the DksA/TraR family with a zinc finger 2197694 7140014 ECED1_2258 Escherichia coli ED1a putative lambdoid prophage protein from the DksA/TraR family with a zinc finger YP_002398197.1 2197485 D 585397 CDS YP_002398198.1 218689986 7140015 2197937..2198065 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2198065 7140015 ECED1_2259 Escherichia coli ED1a hypothetical protein YP_002398198.1 2197937 D 585397 CDS YP_002398199.1 218689987 7140016 2198634..2198867 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2198867 7140016 ECED1_2260 Escherichia coli ED1a hypothetical protein YP_002398199.1 2198634 D 585397 CDS YP_002398200.1 218689988 7140017 2198922..2199650 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14731283, 15546668, 16428391; Product type ps : putative structure; putative type IV secretory pathway VirB1 component 2199650 7140017 ECED1_2261 Escherichia coli ED1a putative type IV secretory pathway VirB1 component YP_002398200.1 2198922 D 585397 CDS YP_002398201.1 218689989 7140018 2199650..2199943 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14731283, 15546668, 16428391; Product type ps : putative structure; putative type IV secretory pathway VirB2 component 2199943 7140018 ECED1_2262 Escherichia coli ED1a putative type IV secretory pathway VirB2 component YP_002398201.1 2199650 D 585397 CDS YP_002398202.1 218689990 7140019 2199956..2202694 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14731283, 15546668, 16428391; Product type ps : putative structure; putative type IV secretory pathway VirB4 component 2202694 7140019 ECED1_2263 Escherichia coli ED1a putative type IV secretory pathway VirB4 component YP_002398202.1 2199956 D 585397 CDS YP_002398203.1 218689991 7140020 2202712..2203419 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14731283, 15546668, 16428391; Product type ps : putative structure; putative type IV secretory pathway VirB5 component 2203419 7140020 ECED1_2264 Escherichia coli ED1a putative type IV secretory pathway VirB5 component YP_002398203.1 2202712 D 585397 CDS YP_002398204.1 218689992 7140021 2203427..2203669 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14731283, 15546668, 16428391; hypothetical protein 2203669 7140021 ECED1_2265 Escherichia coli ED1a hypothetical protein YP_002398204.1 2203427 D 585397 CDS YP_002398205.1 218689993 7140022 2203673..2204746 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14731283, 15546668, 16428391; Product type ps : putative structure; putative type IV secretory pathway VirB6 component 2204746 7140022 ECED1_2266 Escherichia coli ED1a putative type IV secretory pathway VirB6 component YP_002398205.1 2203673 D 585397 CDS YP_002398206.1 218689994 7140023 2204968..2205651 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14731283, 15546668, 16428391; Product type ps : putative structure; putative type IV secretory pathway VirB8 component 2205651 7140023 ECED1_2267 Escherichia coli ED1a putative type IV secretory pathway VirB8 component YP_002398206.1 2204968 D 585397 CDS YP_002398207.1 218689995 7140024 2205648..2206556 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14731283, 15546668, 16428391; Product type ps : putative structure; putative type IV secretory pathway VirB9 component 2206556 7140024 ECED1_2268 Escherichia coli ED1a putative type IV secretory pathway VirB9 component YP_002398207.1 2205648 D 585397 CDS YP_002398208.1 218689996 7140025 2206586..2207842 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14731283, 15546668, 16428391; Product type ps : putative structure; putative type IV secretory pathway VirB10 component 2207842 7140025 ECED1_2269 Escherichia coli ED1a putative type IV secretory pathway VirB10 component YP_002398208.1 2206586 D 585397 CDS YP_002398209.1 218689997 7140026 2207832..2208857 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14731283, 15546668, 16428391, 2370849, 2233252; Product type ps : putative structure; putative type IV secretory pathway VirB11 component 2208857 7140026 ECED1_2270 Escherichia coli ED1a putative type IV secretory pathway VirB11 component YP_002398209.1 2207832 D 585397 CDS YP_002398210.1 218689998 7140027 2208854..2209252 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2209252 7140027 ECED1_2271 Escherichia coli ED1a hypothetical protein YP_002398210.1 2208854 D 585397 CDS YP_002398211.1 218689999 7140028 2209288..2209593 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14731283, 8029323, 7891554, 8812785, 1569033; Product type h : extrachromosomal origin; putative plasmid conjugation protein 2209593 kikA 7140028 kikA Escherichia coli ED1a putative plasmid conjugation protein YP_002398211.1 2209288 D 585397 CDS YP_002398212.1 218690000 7142511 2209627..2209932 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14731283; hypothetical protein 2209932 7142511 ECED1_2273 Escherichia coli ED1a hypothetical protein YP_002398212.1 2209627 D 585397 CDS YP_002398213.1 218690001 7140029 2210612..2212501 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14731283, 10940031; Product type h : extrachromosomal origin; putative MobB mobilization protein 2212501 7140029 ECED1_2274 Escherichia coli ED1a putative MobB mobilization protein YP_002398213.1 2210612 D 585397 CDS YP_002398214.1 218690002 7140030 2212511..2213257 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14731283, 10940031, 11251827; Product type h : extrachromosomal origin; putative MobC mobilization protein 2213257 7140030 ECED1_2275 Escherichia coli ED1a putative MobC mobilization protein YP_002398214.1 2212511 D 585397 CDS YP_002398215.1 218690003 7140031 complement(2213451..2214497) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14731283, 10686096; Product type pc : putative carrier; putative Antirestriction protein ardC 2214497 7140031 ECED1_2276 Escherichia coli ED1a putative Antirestriction protein ardC YP_002398215.1 2213451 R 585397 CDS YP_002398216.1 218690004 7140032 complement(2215060..2215323) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 7737514, 1718819, 15126494, 7737514; Product type pe : putative enzyme; Transposase, ORF A, IS3 family, IS407 group 2215323 7140032 ECED1_2277 Escherichia coli ED1a Transposase, ORF A, IS3 family, IS407 group YP_002398216.1 2215060 R 585397 CDS YP_002398217.1 218690005 7140033 complement(2215465..2216523) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2216523 7140033 ECED1_2278 Escherichia coli ED1a hypothetical protein YP_002398217.1 2215465 R 585397 CDS YP_002398218.1 218690006 7140034 complement(2216529..2218313) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2218313 7140034 ECED1_2279 Escherichia coli ED1a hypothetical protein YP_002398218.1 2216529 R 585397 CDS YP_002398219.1 218690007 7140035 complement(2218310..2219875) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative type I restriction modification system protein 2219875 7140035 ECED1_2280 Escherichia coli ED1a putative type I restriction modification system protein YP_002398219.1 2218310 R 585397 CDS YP_002398220.1 218690008 7140036 complement(2219872..2221545) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8412658; Product type pe : putative enzyme; putative HsdM; type I restriction modification enzyme methylase subunit 2221545 7140036 ECED1_2281 Escherichia coli ED1a putative HsdM; type I restriction modification enzyme methylase subunit YP_002398220.1 2219872 R 585397 CDS YP_002398221.1 218690009 7140037 2222625..2229728 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15659678; Product type f : factor; adhesin 2229728 yeeJ 7140037 yeeJ Escherichia coli ED1a adhesin YP_002398221.1 2222625 D 585397 CDS YP_002398222.1 218690010 7140039 2231357..2232673 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 5332864, 9524262; Product type t : transporter; shikimate transporter 2232673 shiA 7140039 shiA Escherichia coli ED1a shikimate transporter YP_002398222.1 2231357 D 585397 CDS YP_002398223.1 218690011 7143795 2232775..2234229 1 NC_011745.1 Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile; AMP nucleosidase 2234229 amn 7143795 amn Escherichia coli ED1a AMP nucleosidase YP_002398223.1 2232775 D 585397 CDS YP_002398224.1 218690012 7143705 2234572..2235288 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2235288 yeeN 7143705 yeeN Escherichia coli ED1a hypothetical protein YP_002398224.1 2234572 D 585397 CDS YP_002398225.1 218690013 7140568 2235527..2235673 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 2235673 7140568 ECED1_2290 Escherichia coli ED1a hypothetical protein YP_002398225.1 2235527 D 585397 CDS YP_002398226.1 218690014 7140622 complement(2235917..2237560) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16042411; Product type pt : putative transporter; hypothetical protein 2237560 yeeO 7140622 yeeO Escherichia coli ED1a hypothetical protein YP_002398226.1 2235917 R 585397 CDS YP_002398227.1 218690015 7140788 2237821..2239095 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Prophage integrase 2239095 int 7140788 int Escherichia coli ED1a Prophage integrase YP_002398227.1 2237821 D 585397 CDS YP_002398228.1 218690016 7141178 complement(2239142..2240596) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative SpnT protein 2240596 7141178 ECED1_2294 Escherichia coli ED1a putative SpnT protein YP_002398228.1 2239142 R 585397 CDS YP_002398229.1 218690017 7140041 2240713..2242611 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; site-specific DNA-methyltransferase, component of type III restriction-modification system 2242611 7140041 ECED1_2295 Escherichia coli ED1a site-specific DNA-methyltransferase, component of type III restriction-modification system YP_002398229.1 2240713 D 585397 CDS YP_002398230.1 218690018 7140042 2242621..2245581 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Type III restriction-modification system site-specific deoxyribonuclease 2245581 7140042 ECED1_2296 Escherichia coli ED1a Type III restriction-modification system site-specific deoxyribonuclease YP_002398230.1 2242621 D 585397 CDS YP_002398231.1 218690019 7140043 complement(2245708..2247279) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative PilV-like protein 2247279 7140043 ECED1_2297 Escherichia coli ED1a putative PilV-like protein YP_002398231.1 2245708 R 585397 CDS YP_002398232.1 218690020 7140044 complement(2247584..2247907) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2247907 7140044 ECED1_2298 Escherichia coli ED1a hypothetical protein YP_002398232.1 2247584 R 585397 CDS YP_002398233.1 218690021 7140045 complement(2247991..2248506) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 2248506 7140045 ECED1_2299 Escherichia coli ED1a hypothetical protein YP_002398233.1 2247991 R 585397 CDS YP_002398234.1 218690022 7140046 complement(2248553..2249062) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2249062 7140046 ECED1_2300 Escherichia coli ED1a hypothetical protein YP_002398234.1 2248553 R 585397 CDS YP_002398235.1 218690023 7140047 complement(2250056..2250403) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 2250403 7140047 ECED1_2301 Escherichia coli ED1a hypothetical protein YP_002398235.1 2250056 R 585397 CDS YP_002398236.1 218690024 7140048 complement(2250400..2250594) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 2250594 7140048 ECED1_2302 Escherichia coli ED1a hypothetical protein YP_002398236.1 2250400 R 585397 CDS YP_002398237.1 218690025 7140049 2250746..2251747 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 2251747 7140049 ECED1_2303 Escherichia coli ED1a hypothetical protein YP_002398237.1 2250746 D 585397 CDS YP_002398238.1 218690026 7140050 2252468..2253949 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative mobilization protein 2253949 7140050 ECED1_2304 Escherichia coli ED1a putative mobilization protein YP_002398238.1 2252468 D 585397 CDS YP_002398239.1 218690027 7140051 complement(2254094..2255050) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; putative Radical SAM superfamily 2255050 7140051 ECED1_2305 Escherichia coli ED1a putative Radical SAM superfamily YP_002398239.1 2254094 R 585397 CDS YP_002398240.1 218690028 7140052 complement(2255050..2256069) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; putative Radical SAM superfamily 2256069 7140052 ECED1_2306 Escherichia coli ED1a putative Radical SAM superfamily YP_002398240.1 2255050 R 585397 CDS YP_002398241.1 218690029 7140053 complement(2256059..2256274) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 2256274 7140053 ECED1_2307 Escherichia coli ED1a hypothetical protein YP_002398241.1 2256059 R 585397 CDS YP_002398242.1 218690030 7140054 complement(2256344..2256490) 1 NC_011745.1 Evidence 6 : Doubtful CDS; Product type h : extrachromosomal origin; hypothetical protein 2256490 7140054 ECED1_2308 Escherichia coli ED1a hypothetical protein YP_002398242.1 2256344 R 585397 CDS YP_002398243.1 218690031 7140055 complement(2257134..2257439) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2257439 7140055 ECED1_2309 Escherichia coli ED1a hypothetical protein YP_002398243.1 2257134 R 585397 CDS YP_002398244.1 218690032 7140056 complement(2257420..2257980) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative lipoprotein 2257980 7140056 ECED1_2310 Escherichia coli ED1a putative lipoprotein YP_002398244.1 2257420 R 585397 CDS YP_002398245.1 218690033 7140057 complement(2257986..2258552) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 2258552 7140057 ECED1_2311 Escherichia coli ED1a hypothetical protein YP_002398245.1 2257986 R 585397 CDS YP_002398246.1 218690034 7140058 2258726..2259073 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative transcriptional regulator 2259073 7140058 ECED1_2312 Escherichia coli ED1a putative transcriptional regulator YP_002398246.1 2258726 D 585397 CDS YP_002398247.1 218690035 7140059 2259980..2260549 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative replication protein 2260549 7140059 ECED1_2313 Escherichia coli ED1a putative replication protein YP_002398247.1 2259980 D 585397 CDS YP_002398248.1 218690036 7140060 2260546..2261346 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2261346 7140060 ECED1_2314 Escherichia coli ED1a hypothetical protein YP_002398248.1 2260546 D 585397 CDS YP_002398249.1 218690037 7140061 2261579..2262559 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 2262559 7140061 ECED1_2315 Escherichia coli ED1a hypothetical protein YP_002398249.1 2261579 D 585397 CDS YP_002398250.1 218690038 7140062 2262696..2263175 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2263175 7140062 ECED1_2316 Escherichia coli ED1a hypothetical protein YP_002398250.1 2262696 D 585397 CDS YP_002398251.1 218690039 7140063 2263334..2263738 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89056689, 94335643, 95267838, 95286558, 99355427, 2404280, 11298273; Product type r : regulator; DNA-binding protein H-NS (Histone-like protein HLP-II) 2263738 hns 7140063 hns Escherichia coli ED1a DNA-binding protein H-NS (Histone-like protein HLP-II) YP_002398251.1 2263334 D 585397 CDS YP_002398252.1 218690040 7139905 complement(2263864..2264244) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 2264244 7139905 ECED1_2318 Escherichia coli ED1a hypothetical protein YP_002398252.1 2263864 R 585397 CDS YP_002398253.1 218690041 7140064 complement(2264296..2264586) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2264586 7140064 ECED1_2319 Escherichia coli ED1a hypothetical protein YP_002398253.1 2264296 R 585397 CDS YP_002398254.1 218690042 7140065 complement(2264665..2265003) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2265003 7140065 ECED1_2320 Escherichia coli ED1a hypothetical protein YP_002398254.1 2264665 R 585397 CDS YP_002398255.1 218690043 7140066 complement(2264990..2265319) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 2265319 7140066 ECED1_2321 Escherichia coli ED1a hypothetical protein YP_002398255.1 2264990 R 585397 CDS YP_002398256.1 218690044 7140067 complement(2265335..2265553) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative DNA binding protein from phage origin 2265553 7140067 ECED1_2322 Escherichia coli ED1a putative DNA binding protein from phage origin YP_002398256.1 2265335 R 585397 CDS YP_002398257.1 218690045 7140068 complement(2265701..2266564) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2266564 7140068 ECED1_2323 Escherichia coli ED1a hypothetical protein YP_002398257.1 2265701 R 585397 CDS YP_002398258.1 218690046 7140069 complement(2267005..2267955) 1 NC_011745.1 LysR-type transcriptional regulator similar to CysB; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates two operons consisting of ABC transporters that are part of the cys regulon; regulated by CysB; transcriptional regulator Cbl 2267955 cbl 7140069 cbl Escherichia coli ED1a transcriptional regulator Cbl YP_002398258.1 2267005 R 585397 CDS YP_002398259.1 218690047 7139308 complement(2268057..2268974) 1 NC_011745.1 Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation; nitrogen assimilation transcriptional regulator 2268974 nac 7139308 nac Escherichia coli ED1a nitrogen assimilation transcriptional regulator YP_002398259.1 2268057 R 585397 CDS YP_002398260.1 218690048 7140789 complement(2269432..2270364) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9298646; hypothetical protein 2270364 erfK 7140789 erfK Escherichia coli ED1a hypothetical protein YP_002398260.1 2269432 R 585397 CDS YP_002398261.1 218690049 7139810 complement(2270429..2271508) 1 NC_011745.1 catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 2271508 cobT 7139810 cobT Escherichia coli ED1a nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase YP_002398261.1 2270429 R 585397 CDS YP_002398262.1 218690050 7142034 complement(2271520..2272263) 1 NC_011745.1 catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole; cobalamin synthase 2272263 cobS 7142034 cobS Escherichia coli ED1a cobalamin synthase YP_002398262.1 2271520 R 585397 CDS YP_002398263.1 218690051 7142033 complement(2272260..2272805) 1 NC_011745.1 catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP; adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase 2272805 cobU 7142033 cobU Escherichia coli ED1a adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase YP_002398263.1 2272260 R 585397 CDS YP_002398264.1 218690052 7140070 complement(2273270..2273434) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2273434 7140070 ECED1_2332 Escherichia coli ED1a hypothetical protein YP_002398264.1 2273270 R 585397 CDS YP_002398265.1 218690053 7140072 complement(2275552..2275677) 1 NC_011745.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF A, IS911 (fragment) 2275677 7140072 ECED1_2334 Escherichia coli ED1a transposase ORF A, IS911 (fragment) YP_002398265.1 2275552 R 585397 CDS YP_002398266.1 218690054 7140073 complement(2275712..2275855) 1 NC_011745.1 Evidence 7 : Gene remnant; hypothetical protein 2275855 7140073 ECED1_2335 Escherichia coli ED1a hypothetical protein YP_002398266.1 2275712 R 585397 CDS YP_002398267.1 218690055 7140074 2275902..2276054 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 2276054 7140074 ECED1_2336 Escherichia coli ED1a hypothetical protein YP_002398267.1 2275902 D 585397 CDS YP_002398268.1 218690056 7140075 2276161..2276277 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 2276277 7140075 ECED1_2337 Escherichia coli ED1a hypothetical protein YP_002398268.1 2276161 D 585397 CDS YP_002398269.1 218690057 7140078 2277701..2278459 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2278459 7140078 ECED1_2340 Escherichia coli ED1a hypothetical protein YP_002398269.1 2277701 D 585397 CDS YP_002398270.1 218690058 7140079 2278516..2279481 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2279481 7140079 ECED1_2341 Escherichia coli ED1a hypothetical protein YP_002398270.1 2278516 D 585397 CDS YP_002398271.1 218690059 7142826 2279484..2280518 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphotriesterase-related protein 2280518 7142826 ECED1_2342 Escherichia coli ED1a putative phosphotriesterase-related protein YP_002398271.1 2279484 D 585397 CDS YP_002398272.1 218690060 7143285 complement(2282833..2283240) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2283240 7143285 ECED1_2347 Escherichia coli ED1a hypothetical protein YP_002398272.1 2282833 R 585397 CDS YP_002398273.1 218690061 7143286 complement(2283228..2283635) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2283635 7143286 ECED1_2348 Escherichia coli ED1a hypothetical protein YP_002398273.1 2283228 R 585397 CDS YP_002398274.1 218690062 7143287 complement(2283889..2284494) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2284494 7143287 ECED1_2349 Escherichia coli ED1a hypothetical protein YP_002398274.1 2283889 R 585397 CDS YP_002398275.1 218690063 7143288 2285285..2285653 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2285653 7143288 ECED1_2351 Escherichia coli ED1a hypothetical protein YP_002398275.1 2285285 D 585397 CDS YP_002398276.1 218690064 7143289 2285735..2286214 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7519596; Product type h : extrachromosomal origin; putative antirestriction protein of plasmid origin 2286214 7143289 ECED1_2352 Escherichia coli ED1a putative antirestriction protein of plasmid origin YP_002398276.1 2285735 D 585397 CDS YP_002398277.1 218690065 7143290 2286260..2286706 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11053371; Product type pf : putative factor; putative DNA repair protein; CP4-44 prophage 2286706 yeeS 7143290 yeeS Escherichia coli ED1a putative DNA repair protein; CP4-44 prophage YP_002398277.1 2286260 D 585397 CDS YP_002398278.1 218690066 7139385 2286769..2286990 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2286990 yeeT 7139385 yeeT Escherichia coli ED1a hypothetical protein YP_002398278.1 2286769 D 585397 CDS YP_002398279.1 218690067 7139390 2287064..2287432 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594833; Product type h : extrachromosomal origin; CP4-44 prophage YeeV-YeeU toxin-antitoxin system toxin 2287432 yeeU 7139390 yeeU Escherichia coli ED1a CP4-44 prophage YeeV-YeeU toxin-antitoxin system toxin YP_002398279.1 2287064 D 585397 CDS YP_002398280.1 218690068 7139400 2288527..2288883 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2288883 yoeF 7139400 yoeF Escherichia coli ED1a hypothetical protein YP_002398280.1 2288527 D 585397 CDS YP_002398281.1 218690069 7140266 complement(2288984..2289379) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2289379 yeeX 7140266 yeeX Escherichia coli ED1a hypothetical protein YP_002398281.1 2288984 R 585397 CDS YP_002398282.1 218690070 7139410 complement(2289485..2290543) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2290543 yeeA 7139410 yeeA Escherichia coli ED1a hypothetical protein YP_002398282.1 2289485 R 585397 CDS YP_002398283.1 218690071 7140562 complement(2290742..2291215) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11850398, 9442027, 8709849; Product type r : regulator; DNA gyrase inhibitor 2291215 sbmC 7140562 sbmC Escherichia coli ED1a DNA gyrase inhibitor YP_002398283.1 2290742 R 585397 CDS YP_002398284.1 218690072 7141375 complement(2291334..2292500) 1 NC_011745.1 removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; penicillin-binding protein 6B; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase 2292500 dacD 7141375 dacD Escherichia coli ED1a D-alanyl-D-alanine carboxypeptidase YP_002398284.1 2291334 R 585397 CDS YP_002398285.1 218690073 7143055 2292709..2294136 1 NC_011745.1 Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates; exonuclease I 2294136 sbcB 7143055 sbcB Escherichia coli ED1a exonuclease I YP_002398285.1 2292709 D 585397 CDS YP_002398286.1 218690074 7141371 complement(2294179..2294406) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2294406 yeeD 7141371 yeeD Escherichia coli ED1a hypothetical protein YP_002398286.1 2294179 R 585397 CDS YP_002398287.1 218690075 7140563 complement(2294420..2295478) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2295478 yeeE 7140563 yeeE Escherichia coli ED1a hypothetical protein YP_002398287.1 2294420 R 585397 CDS YP_002398288.1 218690076 7140564 complement(2295657..2297015) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative amino-acid/amine transporter 2297015 yeeF 7140564 yeeF Escherichia coli ED1a putative amino-acid/amine transporter YP_002398288.1 2295657 R 585397 CDS YP_002398289.1 218690077 7140565 complement(2297282..2298211) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 2298211 yeeY 7140565 yeeY Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002398289.1 2297282 R 585397 CDS YP_002398290.1 218690078 7139411 complement(2298257..2299081) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative epimerase, with NAD(P)-binding Rossmann-fold domain 2299081 yeeZ 7139411 yeeZ Escherichia coli ED1a putative epimerase, with NAD(P)-binding Rossmann-fold domain YP_002398290.1 2298257 R 585397 CDS YP_002398292.1 218690080 7139896 2299703..2300602 1 NC_011745.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase 2300602 hisG 7139896 hisG Escherichia coli ED1a ATP phosphoribosyltransferase YP_002398292.1 2299703 D 585397 CDS YP_002398293.1 218690081 7139892 2300608..2301912 1 NC_011745.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 2301912 hisD 7139892 hisD Escherichia coli ED1a histidinol dehydrogenase YP_002398293.1 2300608 D 585397 CDS YP_002398294.1 218690082 7139890 2301909..2302979 1 NC_011745.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 2302979 hisC 7139890 hisC Escherichia coli ED1a histidinol-phosphate aminotransferase YP_002398294.1 2301909 D 585397 CDS YP_002398295.1 218690083 7139889 2302979..2304046 1 NC_011745.1 catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate; imidazole glycerol-phosphate dehydratase/histidinol phosphatase 2304046 hisB 7139889 hisB Escherichia coli ED1a imidazole glycerol-phosphate dehydratase/histidinol phosphatase YP_002398295.1 2302979 D 585397 CDS YP_002398296.1 218690084 7139888 2304046..2304636 1 NC_011745.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 2304636 hisH 7139888 hisH Escherichia coli ED1a imidazole glycerol phosphate synthase subunit HisH YP_002398296.1 2304046 D 585397 CDS YP_002398297.1 218690085 7139893 2304636..2305373 1 NC_011745.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 2305373 hisA 7139893 hisA Escherichia coli ED1a 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase YP_002398297.1 2304636 D 585397 CDS YP_002398298.1 218690086 7139887 2305355..2306131 1 NC_011745.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 2306131 hisF 7139887 hisF Escherichia coli ED1a imidazole glycerol phosphate synthase subunit HisF YP_002398298.1 2305355 D 585397 CDS YP_002398299.1 218690087 7139891 2306125..2306736 1 NC_011745.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis; bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein 2306736 hisI 7139891 hisI Escherichia coli ED1a bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein YP_002398299.1 2306125 D 585397 CDS YP_002398300.1 218690088 7139894 complement(2306833..2307867) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98241528; Product type r : regulator; regulator of length of O-antigen component of lipopolysaccharide chains 2307867 cld 7139894 cld Escherichia coli ED1a regulator of length of O-antigen component of lipopolysaccharide chains YP_002398300.1 2306833 R 585397 CDS YP_002398301.1 218690089 7139370 complement(2307957..2309123) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9150218, 96326333; Product type e : enzyme; UDP-glucose 6-dehydrogenase 2309123 ugd 7139370 ugd Escherichia coli ED1a UDP-glucose 6-dehydrogenase YP_002398301.1 2307957 R 585397 CDS YP_002398302.1 218690090 7140868 complement(2309371..2310777) 1 NC_011745.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 2310777 gnd 7140868 gnd Escherichia coli ED1a 6-phosphogluconate dehydrogenase YP_002398302.1 2309371 R 585397 CDS YP_002398303.1 218690091 7142997 complement(2311026..2311832) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Glycosyltransferase 2311832 wbdN 7142997 wbdN Escherichia coli ED1a Glycosyltransferase YP_002398303.1 2311026 R 585397 CDS YP_002398304.1 218690092 7139177 complement(2311811..2312857) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glycosyltransferase WbdM 2312857 7139177 ECED1_2380 Escherichia coli ED1a putative glycosyltransferase WbdM YP_002398304.1 2311811 R 585397 CDS YP_002398305.1 218690093 7143291 complement(2312902..2313624) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; putative glycosyltransferase 2313624 7143291 ECED1_2381 Escherichia coli ED1a putative glycosyltransferase YP_002398305.1 2312902 R 585397 CDS YP_002398306.1 218690094 7143292 complement(2315130..2315936) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; putative glycosyltransferase 2315936 7143292 ECED1_2382 Escherichia coli ED1a putative glycosyltransferase YP_002398306.1 2315130 R 585397 CDS YP_002398307.1 218690095 7143293 complement(2315933..2317105) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative CDP-glycerol:poly(Glycerophosphate) glycerophosphotransferase 2317105 7143293 ECED1_2383 Escherichia coli ED1a putative CDP-glycerol:poly(Glycerophosphate) glycerophosphotransferase YP_002398307.1 2315933 R 585397 CDS YP_002398308.1 218690096 7143294 complement(2317089..2318390) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2318390 7143294 ECED1_2384 Escherichia coli ED1a hypothetical protein YP_002398308.1 2317089 R 585397 CDS YP_002398309.1 218690097 7143295 complement(2318463..2318858) 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11882717, 1906926, 8393871, 9182537, 11487587, 10508782; Product type e : enzyme; glycerol-3-phosphate cytidylyltransferase 2318858 tagD 7143295 tagD Escherichia coli ED1a glycerol-3-phosphate cytidylyltransferase YP_002398309.1 2318463 R 585397 CDS YP_002398310.1 218690098 7141505 complement(2319224..2320261) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89274199, 92253563, 92338916, 3022232, 6301942, 8564363, 8611559, 893113; Product type e : enzyme; UDP-glucose 4-epimerase 2320261 7141505 ECED1_2386 Escherichia coli ED1a UDP-glucose 4-epimerase YP_002398310.1 2319224 R 585397 CDS YP_002398311.1 218690099 7143296 complement(2320893..2321786) 1 NC_011745.1 together with GalU subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; UTP--glucose-1-phosphate uridylyltransferase subunit GalF 2321786 galF 7143296 galF Escherichia coli ED1a UTP--glucose-1-phosphate uridylyltransferase subunit GalF YP_002398311.1 2320893 R 585397 CDS YP_002398312.1 218690100 7143149 complement(2322029..2323024) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11976290; Product type e : enzyme; UDP-N-acetylglucosamine 4-epimerase (UDP-GlcNAc 4-epimerase) 2323024 gne 7143149 gne Escherichia coli ED1a UDP-N-acetylglucosamine 4-epimerase (UDP-GlcNAc 4-epimerase) YP_002398312.1 2322029 R 585397 CDS YP_002398313.1 218690101 7142998 complement(2323182..2324576) 1 NC_011745.1 WcaM from Salmonella enterica is essential for biofilm formation on HEp-2 cells and chicken intestinal tissue but not on a plastic surface; may be involved in the biosynthesis of colanic acid; putative colanic acid biosynthesis protein 2324576 wcaM 7142998 wcaM Escherichia coli ED1a putative colanic acid biosynthesis protein YP_002398313.1 2323182 R 585397 CDS YP_002398314.1 218690102 7139188 complement(2324587..2325807) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96326333; Product type pe : putative enzyme; putative glycosyl transferase 2325807 wcaL 7139188 wcaL Escherichia coli ED1a putative glycosyl transferase YP_002398314.1 2324587 R 585397 CDS YP_002398315.1 218690103 7139187 complement(2325804..2327084) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96326333, 8759852, 11004393; Product type pe : putative enzyme; putative pyruvyl transferase 2327084 wcaK 7139187 wcaK Escherichia coli ED1a putative pyruvyl transferase YP_002398315.1 2325804 R 585397 CDS YP_002398316.1 218690104 7139186 complement(2327456..2328934) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96326333, 8759852; Product type pt : putative transporter; colanic acid exporter 2328934 wzxC 7139186 wzxC Escherichia coli ED1a colanic acid exporter YP_002398316.1 2327456 R 585397 CDS YP_002398317.1 218690105 7139193 complement(2328936..2330330) 1 NC_011745.1 WcaJ; glucose-1-phosphate transferase responsible for the addition of the first glucose-1-phosphate from UDP-glucose to the lipid carrier undecaprenyl phosphate in the biosynthesis of colanic acid; putative UDP-glucose lipid carrier transferase 2330330 wcaJ 7139193 wcaJ Escherichia coli ED1a putative UDP-glucose lipid carrier transferase YP_002398317.1 2328936 R 585397 CDS YP_002398318.1 218690106 7139185 complement(2330385..2331755) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93106949, 96326333, 7815923, 8759852; Product type e : enzyme; phosphomannomutase 2331755 cpsG 7139185 cpsG Escherichia coli ED1a phosphomannomutase YP_002398318.1 2330385 R 585397 CDS YP_002398319.1 218690107 7142044 complement(2332036..2333472) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82100097, 85006781, 92048476, 93122523, 96326333, 7815923, 8759852; Product type e : enzyme; mannose-1-phosphate guanyltransferase 2333472 cpsB 7142044 cpsB Escherichia coli ED1a mannose-1-phosphate guanyltransferase YP_002398319.1 2332036 R 585397 CDS YP_002398320.1 218690108 7142043 complement(2333475..2334698) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15670885, 96326333; Product type pe : putative enzyme; putative glycosyl transferase 2334698 wcaI 7142043 wcaI Escherichia coli ED1a putative glycosyl transferase YP_002398320.1 2333475 R 585397 CDS YP_002398321.1 218690109 7139184 complement(2334695..2335174) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96326333, 10913267, 7592609, 7815923, 8759852; Product type e : enzyme; GDP-mannose mannosyl hydrolase 2335174 nudD 7139184 nudD Escherichia coli ED1a GDP-mannose mannosyl hydrolase YP_002398321.1 2334695 R 585397 CDS YP_002398322.1 218690110 7139939 complement(2335177..2336142) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96326333, 98132401, 9862812, 7815923, 8759852, 9473059; Product type e : enzyme; bifunctional GDP-fucose synthetase: GDP-4-dehydro-6-deoxy-D-mannose epimerase and GDP-4-dehydro-6-L-deoxygalactose reductase 2336142 fcl 7139939 fcl Escherichia coli ED1a bifunctional GDP-fucose synthetase: GDP-4-dehydro-6-deoxy-D-mannose epimerase and GDP-4-dehydro-6-L-deoxygalactose reductase YP_002398322.1 2335177 R 585397 CDS YP_002398323.1 218690111 7144135 complement(2336145..2337266) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20139699, 97400210, 10673432, 7815923, 8759852, 9257704, 14299611; Product type e : enzyme; GDP-D-mannose dehydratase, NAD(P)-binding 2337266 gmd 7144135 gmd Escherichia coli ED1a GDP-D-mannose dehydratase, NAD(P)-binding YP_002398323.1 2336145 R 585397 CDS YP_002398324.1 218690112 7142993 complement(2337293..2337841) 1 NC_011745.1 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); putative colanic acid biosynthesis acetyltransferase WcaF 2337841 wcaF 7142993 wcaF Escherichia coli ED1a putative colanic acid biosynthesis acetyltransferase WcaF YP_002398324.1 2337293 R 585397 CDS YP_002398325.1 218690113 7139183 complement(2337857..2338603) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11371548, 96326333, 8759852; Product type pe : putative enzyme; putative glycosyl transferase 2338603 wcaE 7139183 wcaE Escherichia coli ED1a putative glycosyl transferase YP_002398325.1 2337857 R 585397 CDS YP_002398326.1 218690114 7139182 complement(2338614..2339831) 1 NC_011745.1 essential for colanic acid biosynthesis; colanic acid is an exopolysaccharide produced under stress conditions that confers acid and heat tolerance; putative colanic acid biosynthesis protein 2339831 wcaD 7139182 wcaD Escherichia coli ED1a putative colanic acid biosynthesis protein YP_002398326.1 2338614 R 585397 CDS YP_002398327.1 218690115 7139181 complement(2339806..2341023) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96326333; Product type pe : putative enzyme; putative glycosyl transferase 2341023 wcaC 7139181 wcaC Escherichia coli ED1a putative glycosyl transferase YP_002398327.1 2339806 R 585397 CDS YP_002398328.1 218690116 7139180 complement(2341020..2341508) 1 NC_011745.1 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); wcaB is induced in sessile bacteria and by osmotic shock, and repressed when grown in rich medium; putative colanic acid biosynthesis acetyltransferase WcaB 2341508 wcaB 7139180 wcaB Escherichia coli ED1a putative colanic acid biosynthesis acetyltransferase WcaB YP_002398328.1 2341020 R 585397 CDS YP_002398329.1 218690117 7139179 complement(2341511..2342350) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96326333; Product type pe : putative enzyme; putative glycosyl transferase 2342350 wcaA 7139179 wcaA Escherichia coli ED1a putative glycosyl transferase YP_002398329.1 2341511 R 585397 CDS YP_002398330.1 218690118 7139178 complement(2342506..2344668) 1 NC_011745.1 Wzc; catalyzes the autophosphorylation on tyrosine residues which downregulates the biosynthesis of colonic acid (an extracellular polysaccharide); tyrosine kinase 2344668 wzc 7139178 wzc Escherichia coli ED1a tyrosine kinase YP_002398330.1 2342506 R 585397 CDS YP_002398331.1 218690119 7139192 complement(2344671..2345114) 1 NC_011745.1 Wzb shows phosphatase activity towards the autophosphorylated Wzc protein, which induces colanic acid biosynthesis; catalyzes the phosphorylation of UDP-glucose dehydrogenase, an enzyme involved in colanic acid biosynthesis; tyrosine phosphatase 2345114 wzb 7139192 wzb Escherichia coli ED1a tyrosine phosphatase YP_002398331.1 2344671 R 585397 CDS YP_002398332.1 218690120 7139191 complement(2345120..2346259) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 15090537, 96326333, 8759852, 8763957; Product type lp : lipoprotein; capsular polysaccharide translocation lipoprotein 2346259 wza 7139191 wza Escherichia coli ED1a capsular polysaccharide translocation lipoprotein YP_002398332.1 2345120 R 585397 CDS YP_002398333.1 218690121 7139190 2346918..2348501 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; fused putative membrane protein ; putative membrane protein 2348501 yegH 7139190 yegH Escherichia coli ED1a fused putative membrane protein ; putative membrane protein YP_002398333.1 2346918 D 585397 CDS YP_002398334.1 218690122 7139415 complement(2348775..2350628) 1 NC_011745.1 YegA; inner membrane protein involved in the assembly of outer membrane proteins (OMPs); asmA-null mutants show low lipopolysaccharide (LPS) levels, suggesting a role in LPS biogenesis and/or in restricting outer membrane fluidity, resulting on altered assembly of OMPs; putative assembly protein 2350628 asmA 7139415 asmA Escherichia coli ED1a putative assembly protein YP_002398334.1 2348775 R 585397 CDS YP_002398335.1 218690123 7142644 complement(2350650..2351231) 1 NC_011745.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 2351231 dcd 7142644 dcd Escherichia coli ED1a deoxycytidine triphosphate deaminase YP_002398335.1 2350650 R 585397 CDS YP_002398336.1 218690124 7143068 complement(2351323..2351964) 1 NC_011745.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase 2351964 udk 7143068 udk Escherichia coli ED1a uridine kinase YP_002398336.1 2351323 R 585397 CDS YP_002398337.1 218690125 7140866 2352282..2355599 1 NC_011745.1 contains a MASE1 (Membrane-Associated Sensor) domain; potentially involved in signal transduction; putative sensor protein 2355599 yegE 7140866 yegE Escherichia coli ED1a putative sensor protein YP_002398337.1 2352282 D 585397 CDS YP_002398338.1 218690126 7139414 complement(2355717..2356565) 1 NC_011745.1 inducible, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine; 3-methyl-adenine DNA glycosylase II 2356565 alkA 7139414 alkA Escherichia coli ED1a 3-methyl-adenine DNA glycosylase II YP_002398338.1 2355717 R 585397 CDS YP_002398339.1 218690127 7143688 2356699..2358051 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 6094528, 7940673, 7984428; Product type pf : putative factor; putative chaperone 2358051 yegD 7143688 yegD Escherichia coli ED1a putative chaperone YP_002398339.1 2356699 D 585397 CDS YP_002398340.1 218690128 7139413 complement(2358064..2360010) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2360010 yegI 7139413 yegI Escherichia coli ED1a hypothetical protein YP_002398340.1 2358064 R 585397 CDS YP_002398341.1 218690129 7139416 2360210..2360671 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2360671 yegJ 7139416 yegJ Escherichia coli ED1a hypothetical protein YP_002398341.1 2360210 D 585397 CDS YP_002398342.1 218690130 7139417 complement(2360736..2361497) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2361497 yegK 7139417 yegK Escherichia coli ED1a hypothetical protein YP_002398342.1 2360736 R 585397 CDS YP_002398343.1 218690131 7139418 complement(2361494..2362153) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2362153 yegL 7139418 yegL Escherichia coli ED1a hypothetical protein YP_002398343.1 2361494 R 585397 CDS YP_002398344.1 218690132 7140156 2363041..2364288 1 NC_011745.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtA 2364288 mdtA 7140156 mdtA Escherichia coli ED1a multidrug efflux system subunit MdtA YP_002398344.1 2363041 D 585397 CDS YP_002398345.1 218690133 7142227 2364288..2367410 1 NC_011745.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtB 2367410 mdtB 7142227 mdtB Escherichia coli ED1a multidrug efflux system subunit MdtB YP_002398345.1 2364288 D 585397 CDS YP_002398346.1 218690134 7142228 2367411..2370488 1 NC_011745.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC; confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtC 2370488 mdtC 7142228 mdtC Escherichia coli ED1a multidrug efflux system subunit MdtC YP_002398346.1 2367411 D 585397 CDS YP_002398347.1 218690135 7142229 2370489..2371904 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12107134, 21450803, 8282725; Product type t : transporter; multidrug efflux system protein MdtE 2371904 mdtD 7142229 mdtD Escherichia coli ED1a multidrug efflux system protein MdtE YP_002398347.1 2370489 D 585397 CDS YP_002398348.1 218690136 7142230 2371901..2373304 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94110256, 8282725; Product type r : regulator; signal transduction histidine-protein kinase BaeS 2373304 baeS 7142230 baeS Escherichia coli ED1a signal transduction histidine-protein kinase BaeS YP_002398348.1 2371901 D 585397 CDS YP_002398349.1 218690137 7140428 2373301..2374023 1 NC_011745.1 response regulator in two-component regulatory system with BaeS; regulator of RNA synthesis, flagellar biosynthesis, chemotaxis and transport; DNA-binding transcriptional regulator BaeR 2374023 baeR 7140428 baeR Escherichia coli ED1a DNA-binding transcriptional regulator BaeR YP_002398349.1 2373301 D 585397 CDS YP_002398350.1 218690138 7140427 2374203..2374535 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2374535 yegP 7140427 yegP Escherichia coli ED1a hypothetical protein YP_002398350.1 2374203 D 585397 CDS YP_002398351.1 218690139 7139420 complement(2374660..2375274) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2375274 7139420 ECED1_2427 Escherichia coli ED1a hypothetical protein YP_002398351.1 2374660 R 585397 CDS YP_002398352.1 218690140 7143304 complement(2375326..2377473) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2377473 7143304 ECED1_2428 Escherichia coli ED1a hypothetical protein YP_002398352.1 2375326 R 585397 CDS YP_002398353.1 218690141 7143305 complement(2377445..2378161) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2378161 7143305 ECED1_2429 Escherichia coli ED1a hypothetical protein YP_002398353.1 2377445 R 585397 CDS YP_002398354.1 218690142 7143306 complement(2378161..2379375) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2379375 7143306 ECED1_2430 Escherichia coli ED1a hypothetical protein YP_002398354.1 2378161 R 585397 CDS YP_002398355.1 218690143 7143307 2379863..2381224 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative peptidase 2381224 yegQ 7143307 yegQ Escherichia coli ED1a putative peptidase YP_002398355.1 2379863 D 585397 CDS YP_002398356.1 218690144 7140157 complement(2381497..2381715) 1 NC_011745.1 in E. coli K-12 this is in prophage P2 remnant; DNA-binding transcriptional regulator 2381715 ogrK 7140157 ogrK Escherichia coli ED1a DNA-binding transcriptional regulator YP_002398356.1 2381497 R 585397 CDS YP_002398357.1 218690145 7139965 complement(2381796..2382959) 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 3458177; Product type h : extrachromosomal origin; phage late control gene D protein 2382959 GpD 7139965 GpD Escherichia coli ED1a phage late control gene D protein YP_002398357.1 2381796 R 585397 CDS YP_002398358.1 218690146 7143009 complement(2382959..2383438) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12426340; Product type h : extrachromosomal origin; tail assembly protein (GpU) 2383438 GpU 7143009 GpU Escherichia coli ED1a tail assembly protein (GpU) YP_002398358.1 2382959 R 585397 CDS YP_002398359.1 218690147 7143018 complement(2383453..2385900) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail fiber protein T 2385900 GpT 7143018 GpT Escherichia coli ED1a tail fiber protein T YP_002398359.1 2383453 R 585397 CDS YP_002398360.1 218690148 7143308 complement(2386045..2386320) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail protein E (GpE) 2386320 GpE 7143308 GpE Escherichia coli ED1a tail protein E (GpE) YP_002398360.1 2386045 R 585397 CDS YP_002398361.1 218690149 7143010 complement(2386377..2386895) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; major tail sheath protein FII 2386895 7143010 ECED1_2438 Escherichia coli ED1a major tail sheath protein FII YP_002398361.1 2386377 R 585397 CDS YP_002398362.1 218690150 7143309 complement(2386908..2388098) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; major tail sheath protein FI 2388098 7143309 ECED1_2439 Escherichia coli ED1a major tail sheath protein FI YP_002398362.1 2386908 R 585397 CDS YP_002398363.1 218690151 7143310 2388417..2388806 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2388806 7143310 ECED1_2440 Escherichia coli ED1a hypothetical protein YP_002398363.1 2388417 D 585397 CDS YP_002398364.1 218690152 7143311 complement(2388829..2389515) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; site-specific recombinase, phage integrase family 2389515 7143311 ECED1_2441 Escherichia coli ED1a site-specific recombinase, phage integrase family YP_002398364.1 2388829 R 585397 CDS YP_002398365.1 218690153 7143312 complement(2389520..2390362) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2390362 7143312 ECED1_2442 Escherichia coli ED1a hypothetical protein YP_002398365.1 2389520 R 585397 CDS YP_002398366.1 218690154 7143313 complement(2390783..2391310) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage tail fiber assembly protein (GpG) 2391310 7143313 ECED1_2443 Escherichia coli ED1a putative phage tail fiber assembly protein (GpG) YP_002398366.1 2390783 R 585397 CDS YP_002398367.1 218690155 7143314 complement(2391314..2393419) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative tail fiber protein (GpH) 2393419 7143314 ECED1_2444 Escherichia coli ED1a putative tail fiber protein (GpH) YP_002398367.1 2391314 R 585397 CDS YP_002398368.1 218690156 7143315 complement(2393430..2393960) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail protein I (GpI) 2393960 7143315 ECED1_2445 Escherichia coli ED1a tail protein I (GpI) YP_002398368.1 2393430 R 585397 CDS YP_002398369.1 218690157 7143316 complement(2393953..2394861) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Baseplate assembly protein GpJ 2394861 7143316 ECED1_2446 Escherichia coli ED1a Baseplate assembly protein GpJ YP_002398369.1 2393953 R 585397 CDS YP_002398370.1 218690158 7143317 complement(2394866..2395213) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Baseplate assembly protein GpW 2395213 7143317 ECED1_2447 Escherichia coli ED1a Baseplate assembly protein GpW YP_002398370.1 2394866 R 585397 CDS YP_002398371.1 218690159 7143318 complement(2395210..2395863) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Baseplate assembly protein GpV 2395863 7143318 ECED1_2448 Escherichia coli ED1a Baseplate assembly protein GpV YP_002398371.1 2395210 R 585397 CDS YP_002398372.1 218690160 7143319 2395929..2396642 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2396642 7143319 ECED1_2449 Escherichia coli ED1a hypothetical protein YP_002398372.1 2395929 D 585397 CDS YP_002398373.1 218690161 7143320 complement(2397082..2397399) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2397399 yegR 7143320 yegR Escherichia coli ED1a hypothetical protein YP_002398373.1 2397082 R 585397 CDS YP_002398374.1 218690162 7139423 complement(2398536..2399039) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 2399039 insB 7139423 insB Escherichia coli ED1a IS1 transposase InsAB' YP_002398374.1 2398536 R 585397 CDS YP_002398375.1 218690163 7141144 complement(2398958..2399233) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 2399233 insA 7141144 insA Escherichia coli ED1a IS1 repressor protein InsA YP_002398375.1 2398958 R 585397 CDS YP_002398376.1 218690164 7141122 2399313..2400317 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative (phospho)hydrolase 2400317 yegU 7141122 yegU Escherichia coli ED1a putative (phospho)hydrolase YP_002398376.1 2399313 D 585397 CDS YP_002398377.1 218690165 7139424 2400314..2401279 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative kinase 2401279 yegV 7139424 yegV Escherichia coli ED1a putative kinase YP_002398377.1 2400314 D 585397 CDS YP_002398378.1 218690166 7139425 complement(2401253..2401999) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 2401999 yegW 7139425 yegW Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002398378.1 2401253 R 585397 CDS YP_002398379.1 218690167 7139426 complement(2402051..2402869) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-bound hydrolase 2402869 yegX 7139426 yegX Escherichia coli ED1a putative membrane-bound hydrolase YP_002398379.1 2402051 R 585397 CDS YP_002398380.1 218690168 7139427 complement(2402934..2403734) 1 NC_011745.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 2403734 thiD 7139427 thiD Escherichia coli ED1a phosphomethylpyrimidine kinase YP_002398380.1 2402934 R 585397 CDS YP_002398381.1 218690169 7141540 complement(2403731..2404519) 1 NC_011745.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase 2404519 thiM 7141540 thiM Escherichia coli ED1a hydroxyethylthiazole kinase YP_002398381.1 2403731 R 585397 CDS YP_002398382.1 218690170 7140756 complement(2404742..2405014) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2405014 yohL 7140756 yohL Escherichia coli ED1a hypothetical protein YP_002398382.1 2404742 R 585397 CDS YP_002398383.1 218690171 7140273 2405135..2405959 1 NC_011745.1 membrane protein conferring nickel and cobalt resistance; nickel/cobalt efflux protein RcnA 2405959 rncA 7140273 rncA Escherichia coli ED1a nickel/cobalt efflux protein RcnA YP_002398383.1 2405135 D 585397 CDS YP_002398384.1 218690172 7141433 2405998..2406516 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2406516 yohN 7141433 yohN Escherichia coli ED1a hypothetical protein YP_002398384.1 2405998 D 585397 CDS YP_002398385.1 218690173 7140274 complement(2406598..2407632) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative exported fimbrial-like adhesin protein 2407632 yehA 7140274 yehA Escherichia coli ED1a putative exported fimbrial-like adhesin protein YP_002398385.1 2406598 R 585397 CDS YP_002398386.1 218690174 7139428 complement(2407648..2410128) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2410128 yehB 7139428 yehB Escherichia coli ED1a hypothetical protein YP_002398386.1 2407648 R 585397 CDS YP_002398387.1 218690175 7139429 complement(2410144..2410818) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative membrane-associated pilin chaperone 2410818 yehC 7139429 yehC Escherichia coli ED1a putative membrane-associated pilin chaperone YP_002398387.1 2410144 R 585397 CDS YP_002398388.1 218690176 7139430 complement(2410899..2411441) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin protein 2411441 yehD 7139430 yehD Escherichia coli ED1a putative fimbrial-like adhesin protein YP_002398388.1 2410899 R 585397 CDS YP_002398389.1 218690177 7139431 complement(2411735..2412016) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2412016 yehE 7139431 yehE Escherichia coli ED1a hypothetical protein YP_002398389.1 2411735 R 585397 CDS YP_002398390.1 218690178 7139432 complement(2412279..2413388) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91080852, 15601724, 2259334; Product type t : transporter; putative ATPase 2413388 mrp 7139432 mrp Escherichia coli ED1a putative ATPase YP_002398390.1 2412279 R 585397 CDS YP_002398391.1 218690179 7139029 2413520..2415553 1 NC_011745.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 2415553 metG 7139029 metG Escherichia coli ED1a methionyl-tRNA synthetase YP_002398391.1 2413520 D 585397 CDS YP_002398392.1 218690180 7142253 2415694..2419482 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2156810; Product type pr : putative regulator; putative Molybdate metabolism regulator (molR) 2419482 7142253 ECED1_2471 Escherichia coli ED1a putative Molybdate metabolism regulator (molR) YP_002398392.1 2415694 D 585397 CDS YP_002398393.1 218690181 7143321 2419492..2423124 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2423124 yehI 7143321 yehI Escherichia coli ED1a hypothetical protein YP_002398393.1 2419492 D 585397 CDS YP_002398394.1 218690182 7139433 2423185..2423505 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2423505 yehK 7139433 yehK Escherichia coli ED1a hypothetical protein YP_002398394.1 2423185 D 585397 CDS YP_002398395.1 218690183 7139434 2424081..2425169 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16428726; Product type pf : putative factor; putative ABC superfamily protein 2425169 yehL 7139434 yehL Escherichia coli ED1a putative ABC superfamily protein YP_002398395.1 2424081 D 585397 CDS YP_002398396.1 218690184 7139435 2425180..2427459 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2427459 yehM 7139435 yehM Escherichia coli ED1a hypothetical protein YP_002398396.1 2425180 D 585397 CDS YP_002398397.1 218690185 7139436 2427452..2428588 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2428588 yehP 7139436 yehP Escherichia coli ED1a hypothetical protein YP_002398397.1 2427452 D 585397 CDS YP_002398398.1 218690186 7139437 2428585..2430588 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2430588 yehQ 7139437 yehQ Escherichia coli ED1a hypothetical protein YP_002398398.1 2428585 D 585397 CDS YP_002398399.1 218690187 7139438 2430713..2431174 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type lp : lipoprotein; hypothetical protein 2431174 yehR 7139438 yehR Escherichia coli ED1a hypothetical protein YP_002398399.1 2430713 D 585397 CDS YP_002398400.1 218690188 7139439 complement(2431215..2431685) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2431685 yehS 7139439 yehS Escherichia coli ED1a hypothetical protein YP_002398400.1 2431215 R 585397 CDS YP_002398401.1 218690189 7139440 complement(2431732..2432451) 1 NC_011745.1 unknown function; when overproduced it confers drug-resistance; putative two-component response-regulatory protein YehT 2432451 yehT 7139440 yehT Escherichia coli ED1a putative two-component response-regulatory protein YehT YP_002398401.1 2431732 R 585397 CDS YP_002398402.1 218690190 7139441 complement(2432448..2434133) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15522865, 15322361; Product type rc : receptor; sensory kinase in two-component system with YehT 2434133 yehU 7139441 yehU Escherichia coli ED1a sensory kinase in two-component system with YehT YP_002398402.1 2432448 R 585397 CDS YP_002398403.1 218690191 7139442 2434648..2434896 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative damage-inducible protein dinI-like 2434896 7139442 ECED1_2483 Escherichia coli ED1a putative damage-inducible protein dinI-like YP_002398403.1 2434648 D 585397 CDS YP_002398404.1 218690192 7143322 complement(2435263..2439288) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10722621, 17220264; Product type h : extrachromosomal origin; serine protease autotransporter 2439288 eaaA 7143322 eaaA Escherichia coli ED1a serine protease autotransporter YP_002398404.1 2435263 R 585397 CDS YP_002398405.1 218690193 7139762 complement(2439562..2440032) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10722621; hypothetical protein 2440032 7139762 ECED1_2485 Escherichia coli ED1a hypothetical protein YP_002398405.1 2439562 R 585397 CDS YP_002398406.1 218690194 7143323 complement(2440120..2441310) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10722621; Product type h : extrachromosomal origin; Immunoglobulin-binding protein from prophage P-EibA 2441310 eibA 7143323 eibA Escherichia coli ED1a Immunoglobulin-binding protein from prophage P-EibA YP_002398406.1 2440120 R 585397 CDS YP_002398407.1 218690195 7139779 complement(2441992..2442648) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10722621; Product type h : extrachromosomal origin; hypothetical protein 2442648 7139779 ECED1_2487 Escherichia coli ED1a hypothetical protein YP_002398407.1 2441992 R 585397 CDS YP_002398408.1 218690196 7143324 complement(2442590..2444071) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative tail fiber protein from prophage 2444071 7143324 ECED1_2488 Escherichia coli ED1a putative tail fiber protein from prophage YP_002398408.1 2442590 R 585397 CDS YP_002398409.1 218690197 7143325 complement(2444256..2447786) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Host specificity protein J (tail component) from prophage 2447786 J 7143325 J Escherichia coli ED1a Host specificity protein J (tail component) from prophage YP_002398409.1 2444256 R 585397 CDS YP_002398410.1 218690198 7142482 complement(2448026..2448706) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail assembly protein I 2448706 7142482 ECED1_2490 Escherichia coli ED1a tail assembly protein I YP_002398410.1 2448026 R 585397 CDS YP_002398411.1 218690199 7143326 complement(2448604..2449341) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail fiber component K 2449341 7143326 ECED1_2491 Escherichia coli ED1a tail fiber component K YP_002398411.1 2448604 R 585397 CDS YP_002398412.1 218690200 7143327 complement(2449396..2450310) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative antirepressor protein in prophage 2450310 7143327 ECED1_2492 Escherichia coli ED1a putative antirepressor protein in prophage YP_002398412.1 2449396 R 585397 CDS YP_002398413.1 218690201 7143329 2450600..2450872 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7999761, 10426954; Product type pr : putative regulator; putative regulatory protein (mnt like) 2450872 7143329 ECED1_2494 Escherichia coli ED1a putative regulatory protein (mnt like) YP_002398413.1 2450600 D 585397 CDS YP_002398414.1 218690202 7143330 2450872..2451408 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative Clp protease 2451408 7143330 ECED1_2495 Escherichia coli ED1a putative Clp protease YP_002398414.1 2450872 D 585397 CDS YP_002398415.1 218690203 7143331 complement(2451465..2452217) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein L 2452217 7143331 ECED1_2496 Escherichia coli ED1a minor tail protein L YP_002398415.1 2451465 R 585397 CDS YP_002398416.1 218690204 7143332 complement(2452360..2453523) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; outer membrane porin protein from phage origin 2453523 7143332 ECED1_2497 Escherichia coli ED1a outer membrane porin protein from phage origin YP_002398416.1 2452360 R 585397 CDS YP_002398417.1 218690205 7143333 complement(2453730..2454071) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11686382, 11282477, 9562894, 8878031; Product type f : factor; minor tail protein M 2454071 7143333 ECED1_2498 Escherichia coli ED1a minor tail protein M YP_002398417.1 2453730 R 585397 CDS YP_002398418.1 218690206 7143334 complement(2454064..2457306) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; tail component measure protein in prophage 2457306 7143334 ECED1_2499 Escherichia coli ED1a tail component measure protein in prophage YP_002398418.1 2454064 R 585397 CDS YP_002398419.1 218690207 7143335 complement(2457370..2457783) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2457783 7143335 ECED1_2500 Escherichia coli ED1a hypothetical protein YP_002398419.1 2457370 R 585397 CDS YP_002398420.1 218690208 7143336 complement(2457847..2458128) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2458128 7143336 ECED1_2501 Escherichia coli ED1a hypothetical protein YP_002398420.1 2457847 R 585397 CDS YP_002398421.1 218690209 7143337 complement(2458152..2458574) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative tail assembly protein in prophage 2458574 7143337 ECED1_2502 Escherichia coli ED1a putative tail assembly protein in prophage YP_002398421.1 2458152 R 585397 CDS YP_002398422.1 218690210 7143338 complement(2458541..2459257) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative major tail subunit in prophage 2459257 7143338 ECED1_2503 Escherichia coli ED1a putative major tail subunit in prophage YP_002398422.1 2458541 R 585397 CDS YP_002398423.1 218690211 7143339 complement(2459324..2459668) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2459668 7143339 ECED1_2504 Escherichia coli ED1a hypothetical protein YP_002398423.1 2459324 R 585397 CDS YP_002398424.1 218690212 7143340 complement(2459665..2460111) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative structural component HK97 gp of phage origin 2460111 7143340 ECED1_2505 Escherichia coli ED1a putative structural component HK97 gp of phage origin YP_002398424.1 2459665 R 585397 CDS YP_002398425.1 218690213 7143341 complement(2460108..2460458) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative head-tail adaptor in prophage 2460458 7143341 ECED1_2506 Escherichia coli ED1a putative head-tail adaptor in prophage YP_002398425.1 2460108 R 585397 CDS YP_002398426.1 218690214 7143342 complement(2460468..2460794) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2460794 7143342 ECED1_2507 Escherichia coli ED1a hypothetical protein YP_002398426.1 2460468 R 585397 CDS YP_002398427.1 218690215 7143343 complement(2460791..2462014) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2462014 7143343 ECED1_2508 Escherichia coli ED1a hypothetical protein YP_002398427.1 2460791 R 585397 CDS YP_002398428.1 218690216 7143344 complement(2462011..2463375) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type s : structure; phage portal protein 2463375 7143344 ECED1_2509 Escherichia coli ED1a phage portal protein YP_002398428.1 2462011 R 585397 CDS YP_002398429.1 218690217 7143345 complement(2463321..2463542) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2463542 7143345 ECED1_2510 Escherichia coli ED1a hypothetical protein YP_002398429.1 2463321 R 585397 CDS YP_002398430.1 218690218 7143346 complement(2463587..2465524) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative major head protein/prohead protease in prophage 2465524 7143346 ECED1_2511 Escherichia coli ED1a putative major head protein/prohead protease in prophage YP_002398430.1 2463587 R 585397 CDS YP_002398431.1 218690219 7143347 complement(2465588..2467249) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative terminase large subunit from phage origin 2467249 7143347 ECED1_2512 Escherichia coli ED1a putative terminase large subunit from phage origin YP_002398431.1 2465588 R 585397 CDS YP_002398432.1 218690220 7143348 complement(2467246..2467809) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative terminase small subunit in prophage 2467809 7143348 ECED1_2513 Escherichia coli ED1a putative terminase small subunit in prophage YP_002398432.1 2467246 R 585397 CDS YP_002398433.1 218690221 7143349 complement(2468099..2468464) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative endonuclease from phage origin 2468464 7143349 ECED1_2514 Escherichia coli ED1a putative endonuclease from phage origin YP_002398433.1 2468099 R 585397 CDS YP_002398434.1 218690222 7143350 2468446..2468706 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2468706 7143350 ECED1_2515 Escherichia coli ED1a hypothetical protein YP_002398434.1 2468446 D 585397 CDS YP_002398435.1 218690223 7143351 complement(2468838..2469179) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative tonB-like membrane protein from phage origin 2469179 7143351 ECED1_2516 Escherichia coli ED1a putative tonB-like membrane protein from phage origin YP_002398435.1 2468838 R 585397 CDS YP_002398436.1 218690224 7143352 complement(2469100..2469453) 1 NC_011745.1 Evidence 6 : Doubtful CDS; Product type h : extrachromosomal origin; hypothetical protein 2469453 7143352 ECED1_2517 Escherichia coli ED1a hypothetical protein YP_002398436.1 2469100 R 585397 CDS YP_002398437.1 218690225 7143353 complement(2469598..2469855) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2469855 7143353 ECED1_2518 Escherichia coli ED1a hypothetical protein YP_002398437.1 2469598 R 585397 CDS YP_002398438.1 218690226 7142744 complement(2469852..2470418) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2470418 7142744 ECED1_2519 Escherichia coli ED1a hypothetical protein YP_002398438.1 2469852 R 585397 CDS YP_002398439.1 218690227 7140649 complement(2470548..2470877) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2470877 7140649 ECED1_2520 Escherichia coli ED1a hypothetical protein YP_002398439.1 2470548 R 585397 CDS YP_002398440.1 218690228 7140652 complement(2470852..2471082) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2471082 7140652 ECED1_2521 Escherichia coli ED1a hypothetical protein YP_002398440.1 2470852 R 585397 CDS YP_002398441.1 218690229 7140653 complement(2471224..2471775) 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Endopeptidase (Lysis protein) from bacteriophage origin 2471775 rz 7140653 rz Escherichia coli ED1a Endopeptidase (Lysis protein) from bacteriophage origin YP_002398441.1 2471224 R 585397 CDS YP_002398442.1 218690230 7141361 complement(2471910..2472227) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2472227 7141361 ECED1_2525 Escherichia coli ED1a hypothetical protein YP_002398442.1 2471910 R 585397 CDS YP_002398443.1 218690231 7140654 complement(2472136..2472831) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative antirepressor in prophage 2472831 7140654 ECED1_2526 Escherichia coli ED1a putative antirepressor in prophage YP_002398443.1 2472136 R 585397 CDS YP_002398444.1 218690232 7140655 complement(2473105..2473638) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-associated lysozyme; Qin prophage 2473638 ydfQ 7140655 ydfQ Escherichia coli ED1a putative membrane-associated lysozyme; Qin prophage YP_002398444.1 2473105 R 585397 CDS YP_002398445.1 218690233 7139268 2473700..2473939 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 2473939 7139268 ECED1_2528 Escherichia coli ED1a hypothetical protein YP_002398445.1 2473700 D 585397 CDS YP_002398446.1 218690234 7140656 complement(2473872..2474402) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2474402 7140656 ECED1_2529 Escherichia coli ED1a hypothetical protein YP_002398446.1 2473872 R 585397 CDS YP_002398447.1 218690235 7140657 complement(2474407..2474622) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage lysis protein S 2474622 essD 7140657 essD Escherichia coli ED1a putative phage lysis protein S YP_002398447.1 2474407 R 585397 CDS YP_002398448.1 218690236 7139815 complement(2474698..2475141) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2475141 7139815 ECED1_2531 Escherichia coli ED1a hypothetical protein YP_002398448.1 2474698 R 585397 CDS YP_002398449.1 218690237 7140658 complement(2475221..2475394) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2475394 7140658 ECED1_2532 Escherichia coli ED1a hypothetical protein YP_002398449.1 2475221 R 585397 CDS YP_002398450.1 218690238 7140659 complement(2475348..2477345) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2477345 7140659 ECED1_2533 Escherichia coli ED1a hypothetical protein YP_002398450.1 2475348 R 585397 CDS YP_002398451.1 218690239 7140660 complement(2478222..2478386) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2478386 7140660 ECED1_2534 Escherichia coli ED1a hypothetical protein YP_002398451.1 2478222 R 585397 CDS YP_002398452.1 218690240 7140661 complement(2478383..2478886) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2478886 7140661 ECED1_2535 Escherichia coli ED1a hypothetical protein YP_002398452.1 2478383 R 585397 CDS YP_002398453.1 218690241 7140621 complement(2479121..2479639) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage antitermination protein Q 2479639 7140621 ECED1_2536 Escherichia coli ED1a putative phage antitermination protein Q YP_002398453.1 2479121 R 585397 CDS YP_002398454.1 218690242 7140663 complement(2479683..2480288) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Protein ninG from prophage 2480288 ninG 7140663 ninG Escherichia coli ED1a Protein ninG from prophage YP_002398454.1 2479683 R 585397 CDS YP_002398455.1 218690243 7140392 complement(2480288..2481016) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; DNA-binding protein from phage origin 2481016 roi 7140392 roi Escherichia coli ED1a DNA-binding protein from phage origin YP_002398455.1 2480288 R 585397 CDS YP_002398456.1 218690244 7141446 complement(2481085..2481798) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Ant antirepressor protein from prophage 2481798 ant 7141446 ant Escherichia coli ED1a Ant antirepressor protein from prophage YP_002398456.1 2481085 R 585397 CDS YP_002398457.1 218690245 7142586 complement(2481738..2481971) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2481971 7142586 ECED1_2540 Escherichia coli ED1a hypothetical protein YP_002398457.1 2481738 R 585397 CDS YP_002398458.1 218690246 7140664 complement(2482256..2482810) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative DNA N-6-adenine-methyltransferase from phage origin 2482810 7140664 ECED1_2541 Escherichia coli ED1a putative DNA N-6-adenine-methyltransferase from phage origin YP_002398458.1 2482256 R 585397 CDS YP_002398459.1 218690247 7140665 complement(2482780..2483328) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative prophage protein ninB 2483328 7140665 ECED1_2542 Escherichia coli ED1a putative prophage protein ninB YP_002398459.1 2482780 R 585397 CDS YP_002398460.1 218690248 7140666 complement(2483183..2483425) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2483425 7140666 ECED1_2543 Escherichia coli ED1a hypothetical protein YP_002398460.1 2483183 R 585397 CDS YP_002398461.1 218690249 7140667 complement(2483430..2483645) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2483645 7140667 ECED1_2544 Escherichia coli ED1a hypothetical protein YP_002398461.1 2483430 R 585397 CDS YP_002398462.1 218690250 7140668 complement(2483731..2484021) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Ren protein from phage origin 2484021 7140668 ECED1_2545 Escherichia coli ED1a Ren protein from phage origin YP_002398462.1 2483731 R 585397 CDS YP_002398463.1 218690251 7140669 complement(2484018..2484719) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative replication protein P of bacteriophage 2484719 7140669 ECED1_2546 Escherichia coli ED1a putative replication protein P of bacteriophage YP_002398463.1 2484018 R 585397 CDS YP_002398464.1 218690252 7140670 complement(2484716..2485654) 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; replication protein from bacteriophage origin 2485654 O 7140670 O Escherichia coli ED1a replication protein from bacteriophage origin YP_002398464.1 2484716 R 585397 CDS YP_002398465.1 218690253 7139980 complement(2485687..2485986) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 375198; Product type h : extrachromosomal origin; regulatory protein CII from phage origin 2485986 7139980 ECED1_2548 Escherichia coli ED1a regulatory protein CII from phage origin YP_002398465.1 2485687 R 585397 CDS YP_002398466.1 218690254 7140671 complement(2486126..2486383) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative repressor protein from phage 2486383 7140671 ECED1_2549 Escherichia coli ED1a putative repressor protein from phage YP_002398466.1 2486126 R 585397 CDS YP_002398467.1 218690255 7140672 2486453..2487100 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Repressor protein CI from phage 2487100 cI 7140672 cI Escherichia coli ED1a Repressor protein CI from phage YP_002398467.1 2486453 D 585397 CDS YP_002398468.1 218690256 7139354 2487097..2487585 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2487585 7139354 ECED1_2551 Escherichia coli ED1a hypothetical protein YP_002398468.1 2487097 D 585397 CDS YP_002398469.1 218690257 7140673 2487582..2488202 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2488202 7140673 ECED1_2552 Escherichia coli ED1a hypothetical protein YP_002398469.1 2487582 D 585397 CDS YP_002398470.1 218690258 7140674 2488636..2488980 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9501914; Product type h : extrachromosomal origin; N protein (anti-termination protein) 2488980 7140674 ECED1_2553 Escherichia coli ED1a N protein (anti-termination protein) YP_002398470.1 2488636 D 585397 CDS YP_002398471.1 218690259 7140675 2488982..2489665 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2489665 7140675 ECED1_2554 Escherichia coli ED1a hypothetical protein YP_002398471.1 2488982 D 585397 CDS YP_002398472.1 218690260 7140676 2489897..2490166 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Host killing protein from bacteriophage origin 2490166 kil 7140676 kil Escherichia coli ED1a Host killing protein from bacteriophage origin YP_002398472.1 2489897 D 585397 CDS YP_002398473.1 218690261 7142513 2490240..2490536 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative host-nuclease inhibitor protein Gam of bacteriophage 2490536 7142513 ECED1_2556 Escherichia coli ED1a putative host-nuclease inhibitor protein Gam of bacteriophage YP_002398473.1 2490240 D 585397 CDS YP_002398474.1 218690262 7140677 2490542..2491327 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 6458018, 6221115; Product type h : extrachromosomal origin; Recombination protein bet from phage origin 2491327 7140677 ECED1_2557 Escherichia coli ED1a Recombination protein bet from phage origin YP_002398474.1 2490542 D 585397 CDS YP_002398475.1 218690263 7140678 2491324..2492004 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; exonuclease from phage origin 2492004 7140678 ECED1_2558 Escherichia coli ED1a exonuclease from phage origin YP_002398475.1 2491324 D 585397 CDS YP_002398476.1 218690264 7140679 2492156..2492908 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2492908 7140679 ECED1_2559 Escherichia coli ED1a hypothetical protein YP_002398476.1 2492156 D 585397 CDS YP_002398477.1 218690265 7140680 2492778..2493131 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2493131 7140680 ECED1_2560 Escherichia coli ED1a hypothetical protein YP_002398477.1 2492778 D 585397 CDS YP_002398478.1 218690266 7140681 2493230..2493451 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2493451 7140681 ECED1_2561 Escherichia coli ED1a hypothetical protein YP_002398478.1 2493230 D 585397 CDS YP_002398479.1 218690267 7140682 2493448..2494143 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2494143 7140682 ECED1_2562 Escherichia coli ED1a hypothetical protein YP_002398479.1 2493448 D 585397 CDS YP_002398480.1 218690268 7140683 2494064..2494336 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2494336 7140683 ECED1_2563 Escherichia coli ED1a hypothetical protein YP_002398480.1 2494064 D 585397 CDS YP_002398481.1 218690269 7140684 2494339..2494617 1 NC_011745.1 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin; hypothetical protein 2494617 7140684 ECED1_2564 Escherichia coli ED1a hypothetical protein YP_002398481.1 2494339 D 585397 CDS YP_002398482.1 218690270 7140685 2494457..2494810 1 NC_011745.1 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin; hypothetical protein 2494810 7140685 ECED1_2565 Escherichia coli ED1a hypothetical protein YP_002398482.1 2494457 D 585397 CDS YP_002398483.1 218690271 7140686 2494838..2495173 1 NC_011745.1 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin; hypothetical protein 2495173 7140686 ECED1_2566 Escherichia coli ED1a hypothetical protein YP_002398483.1 2494838 D 585397 CDS YP_002398484.1 218690272 7140687 2495222..2495500 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2495500 7140687 ECED1_2567 Escherichia coli ED1a hypothetical protein YP_002398484.1 2495222 D 585397 CDS YP_002398485.1 218690273 7140688 2495657..2495911 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Excisionase 2495911 xis 7140688 xis Escherichia coli ED1a Excisionase YP_002398485.1 2495657 D 585397 CDS YP_002398486.1 218690274 7139208 2495945..2497231 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; phage integrase 2497231 int 7139208 int Escherichia coli ED1a phage integrase YP_002398486.1 2495945 D 585397 CDS YP_002398487.1 218690275 7141179 2497306..2497953 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11489123; Product type r : regulator; DNA-binding transcriptional regulator 2497953 mlrA 7141179 mlrA Escherichia coli ED1a DNA-binding transcriptional regulator YP_002398487.1 2497306 D 585397 CDS YP_002398488.1 218690276 7138989 complement(2498101..2498832) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter permease 2498832 yehW 7138989 yehW Escherichia coli ED1a putative ABC transporter permease YP_002398488.1 2498101 R 585397 CDS YP_002398489.1 218690277 7139443 complement(2498837..2499763) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATP-binding protein transporter 2499763 yehX 7139443 yehX Escherichia coli ED1a putative ABC transporter ATP-binding protein transporter YP_002398489.1 2498837 R 585397 CDS YP_002398490.1 218690278 7139444 complement(2499756..2500913) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter permease 2500913 yehY 7139444 yehY Escherichia coli ED1a putative ABC transporter permease YP_002398490.1 2499756 R 585397 CDS YP_002398491.1 218690279 7139445 complement(2500920..2501837) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15251200; Product type pt : putative transporter; putative ABC transporter periplasmic-binding protein 2501837 yehZ 7139445 yehZ Escherichia coli ED1a putative ABC transporter periplasmic-binding protein YP_002398491.1 2500920 R 585397 CDS YP_002398492.1 218690280 7139446 complement(2502027..2504324) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96303506; Product type e : enzyme; beta-D-glucoside glucohydrolase 2504324 bglX 7139446 bglX Escherichia coli ED1a beta-D-glucoside glucohydrolase YP_002398492.1 2502027 R 585397 CDS YP_002398493.1 218690281 7140449 2504520..2506235 1 NC_011745.1 component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent; D-lactate dehydrogenase 2506235 dld 7140449 dld Escherichia coli ED1a D-lactate dehydrogenase YP_002398493.1 2504520 D 585397 CDS YP_002398494.1 218690282 7140497 complement(2506274..2507206) 1 NC_011745.1 specifically hydrolyze the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi; Penicillin-binding protein 7; D-alanyl-D-alanine endopeptidase 2507206 pbpG 7140497 pbpG Escherichia coli ED1a D-alanyl-D-alanine endopeptidase YP_002398494.1 2506274 R 585397 CDS YP_002398495.1 218690283 7144047 complement(2507380..2507967) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2507967 yohC 7144047 yohC Escherichia coli ED1a hypothetical protein YP_002398495.1 2507380 R 585397 CDS YP_002398496.1 218690284 7140267 2508137..2508715 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2508715 yohD 7140267 yohD Escherichia coli ED1a hypothetical protein YP_002398496.1 2508137 D 585397 CDS YP_002398497.1 218690285 7140268 complement(2508835..2509596) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; acetoin dehydrogenase 2509596 yohF 7140268 yohF Escherichia coli ED1a acetoin dehydrogenase YP_002398497.1 2508835 R 585397 CDS YP_002398498.1 218690286 7140269 complement(2509649..2510737) 1 NC_011745.1 may be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug resistance outer membrane protein MdtQ 2510737 yohG 7140269 yohG Escherichia coli ED1a multidrug resistance outer membrane protein MdtQ YP_002398498.1 2509649 R 585397 CDS YP_002398499.1 218690287 7140270 2511639..2512706 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transposase, IS110 family 2512706 7140270 ECED1_2585 Escherichia coli ED1a putative transposase, IS110 family YP_002398499.1 2511639 D 585397 CDS YP_002398500.1 218690288 7140689 2512915..2513097 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2513097 7140689 ECED1_2586 Escherichia coli ED1a hypothetical protein YP_002398500.1 2512915 D 585397 CDS YP_002398501.1 218690289 7140690 complement(2513166..2514182) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 22095566; Product type e : enzyme; tRNA-dihydrouridine synthase C 2514182 dusC 7140690 dusC Escherichia coli ED1a tRNA-dihydrouridine synthase C YP_002398501.1 2513166 R 585397 CDS YP_002398502.1 218690290 7140533 2514355..2514753 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2514753 yohJ 7140533 yohJ Escherichia coli ED1a hypothetical protein YP_002398502.1 2514355 D 585397 CDS YP_002398503.1 218690291 7140271 2514750..2515445 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2515445 yohK 7140271 yohK Escherichia coli ED1a hypothetical protein YP_002398503.1 2514750 D 585397 CDS YP_002398504.1 218690292 7140272 2515575..2516459 1 NC_011745.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 2516459 cdd 7140272 cdd Escherichia coli ED1a cytidine deaminase YP_002398504.1 2515575 D 585397 CDS YP_002398505.1 218690293 7139324 2516609..2517328 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 96125233, 1567863, 8550448; hypothetical protein 2517328 sanA 7139324 sanA Escherichia coli ED1a hypothetical protein YP_002398505.1 2516609 D 585397 CDS YP_002398506.1 218690294 7141363 2517331..2517570 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2517570 yeiS 7141363 yeiS Escherichia coli ED1a hypothetical protein YP_002398506.1 2517331 D 585397 CDS YP_002398507.1 218690295 7139459 2517764..2519002 1 NC_011745.1 function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain; putative oxidoreductase 2519002 yeiT 7139459 yeiT Escherichia coli ED1a putative oxidoreductase YP_002398507.1 2517764 D 585397 CDS YP_002398508.1 218690296 7139460 2518996..2520231 1 NC_011745.1 catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines; dihydropyrimidine dehydrogenase 2520231 yeiA 7139460 yeiA Escherichia coli ED1a dihydropyrimidine dehydrogenase YP_002398508.1 2518996 D 585397 CDS YP_002398509.1 218690297 7139447 complement(2520474..2521484) 1 NC_011745.1 ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex; beta-methylgalactoside transporter inner membrane component 2521484 mglC 7139447 mglC Escherichia coli ED1a beta-methylgalactoside transporter inner membrane component YP_002398509.1 2520474 R 585397 CDS YP_002398510.1 218690298 7142266 complement(2521500..2523020) 1 NC_011745.1 with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains; galactose/methyl galaxtoside transporter ATP-binding protein 2523020 mglA 7142266 mglA Escherichia coli ED1a galactose/methyl galaxtoside transporter ATP-binding protein YP_002398510.1 2521500 R 585397 CDS YP_002398511.1 218690299 7142264 complement(2523081..2524079) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87286407, 92049246, 1719366, 3057628, 3302609, 3600760, 6340108, 6885805, 7012152, 9298646; Product type t : transporter; methyl-galactoside ABC transporter subunit periplasmic-binding protein 2524079 mglB 7142264 mglB Escherichia coli ED1a methyl-galactoside ABC transporter subunit periplasmic-binding protein YP_002398511.1 2523081 R 585397 CDS YP_002398512.1 218690300 7142265 complement(2524359..2525399) 1 NC_011745.1 negative regulator of the mglBAC operon for galactose utilization; DNA-binding transcriptional regulator GalS 2525399 galS 7142265 galS Escherichia coli ED1a DNA-binding transcriptional regulator GalS YP_002398512.1 2524359 R 585397 CDS YP_002398513.1 218690301 7143154 2525389..2525592 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2525592 7143154 ECED1_2599 Escherichia coli ED1a hypothetical protein YP_002398513.1 2525389 D 585397 CDS YP_002398514.1 218690302 7140691 complement(2525541..2526698) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2526698 yeiB 7140691 yeiB Escherichia coli ED1a hypothetical protein YP_002398514.1 2525541 R 585397 CDS YP_002398515.1 218690303 7139448 complement(2526715..2527383) 1 NC_011745.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 2527383 folE 7139448 folE Escherichia coli ED1a GTP cyclohydrolase I YP_002398515.1 2526715 R 585397 CDS YP_002398516.1 218690304 7142159 2527537..2527713 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2527713 7142159 ECED1_2602 Escherichia coli ED1a hypothetical protein YP_002398516.1 2527537 D 585397 CDS YP_002398517.1 218690305 7140692 2527641..2528477 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16567800; Product type e : enzyme; S-formylglutathione hydrolase 2528477 frmC 7140692 frmC Escherichia coli ED1a S-formylglutathione hydrolase YP_002398517.1 2527641 D 585397 CDS YP_002398518.1 218690306 7142173 complement(2528509..2530434) 1 NC_011745.1 Cir; FeuA; CirA; receptor protein for siderophores (colicin IA, IB and V) and microcins (E492, H47, and M); TonB-dependent; able to transport monomers, dimer, and linear trimers of 2,3-dihydorxybenzoylserine; outer membrane protein; colicin I receptor 2530434 cirA 7142173 cirA Escherichia coli ED1a colicin I receptor YP_002398518.1 2528509 R 585397 CDS YP_002398519.1 218690307 7139358 complement(2530792..2532261) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92250419, 94252996, 1315732, 7551055; Product type t : transporter; lysine transporter 2532261 lysP 7139358 lysP Escherichia coli ED1a lysine transporter YP_002398519.1 2530792 R 585397 CDS YP_002398520.1 218690308 7141933 complement(2532466..2533347) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12400704, 1315732; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 2533347 yeiE 7141933 yeiE Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002398520.1 2532466 R 585397 CDS YP_002398521.1 218690309 7139450 2533446..2534495 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2534495 yeiH 7139450 yeiH Escherichia coli ED1a hypothetical protein YP_002398521.1 2533446 D 585397 CDS YP_002398522.1 218690310 7139451 2534569..2535426 1 NC_011745.1 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues; endonuclease IV 2535426 nfo 7139451 nfo Escherichia coli ED1a endonuclease IV YP_002398522.1 2534569 D 585397 CDS YP_002398523.1 218690311 7140377 2535430..2536518 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 2536518 yeiI 7140377 yeiI Escherichia coli ED1a hypothetical protein YP_002398523.1 2535430 D 585397 CDS YP_002398524.1 218690312 7139452 complement(2536786..2537727) 1 NC_011745.1 Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively; ribonucleoside hydrolase 2 2537727 rihB 7139452 rihB Escherichia coli ED1a ribonucleoside hydrolase 2 YP_002398524.1 2536786 R 585397 CDS YP_002398525.1 218690313 7141414 2537896..2538555 1 NC_011745.1 activator of nucleoside metabolism; DNA-binding transcriptional activator YeiL 2538555 yeiL 7141414 yeiL Escherichia coli ED1a DNA-binding transcriptional activator YeiL YP_002398525.1 2537896 D 585397 CDS YP_002398526.1 218690314 7139453 complement(2538622..2539872) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sodium/proton nucleoside transporter 2539872 yeiM 7139453 yeiM Escherichia coli ED1a putative sodium/proton nucleoside transporter YP_002398526.1 2538622 R 585397 CDS YP_002398527.1 218690315 7139454 complement(2539966..2540904) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2540904 yeiN 7139454 yeiN Escherichia coli ED1a hypothetical protein YP_002398527.1 2539966 R 585397 CDS YP_002398528.1 218690316 7139455 complement(2540892..2541947) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 2541947 yeiC 7139455 yeiC Escherichia coli ED1a hypothetical protein YP_002398528.1 2540892 R 585397 CDS YP_002398529.1 218690317 7139449 complement(2542289..2543980) 1 NC_011745.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system fructose-specific transporter subunits IIBC 2543980 fruA 7139449 fruA Escherichia coli ED1a PTS system fructose-specific transporter subunits IIBC YP_002398529.1 2542289 R 585397 CDS YP_002398530.1 218690318 7142177 complement(2543997..2544935) 1 NC_011745.1 converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers; 1-phosphofructokinase 2544935 fruK 7142177 fruK Escherichia coli ED1a 1-phosphofructokinase YP_002398530.1 2543997 R 585397 CDS YP_002398531.1 218690319 7142179 complement(2544935..2546065) 1 NC_011745.1 phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr; bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein 2546065 fruB 7142179 fruB Escherichia coli ED1a bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein YP_002398531.1 2544935 R 585397 CDS YP_002398532.1 218690320 7141402 complement(2547611..2547997) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2547997 7141402 ECED1_2620 Escherichia coli ED1a hypothetical protein YP_002398532.1 2547611 R 585397 CDS YP_002398533.1 218690321 7140693 2548020..2548592 1 NC_011745.1 Stimulates the peptidyltransferase activity of the 70S ribosome and enhances dipeptide synthesis with N-formylmethionyl-tRNA and puromycin in vitro, suggesting its involvement in the formation of the first peptide bond of a protein; elongation factor P 2548592 yeiP 7140693 yeiP Escherichia coli ED1a elongation factor P YP_002398533.1 2548020 D 585397 CDS YP_002398534.1 218690322 7139456 2548815..2550281 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sugar dehydrogenase, NAD-dependent 2550281 yeiQ 7139456 yeiQ Escherichia coli ED1a putative sugar dehydrogenase, NAD-dependent YP_002398534.1 2548815 D 585397 CDS YP_002398535.1 218690323 7139457 2550399..2551385 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 2551385 yeiR 7139457 yeiR Escherichia coli ED1a hypothetical protein YP_002398535.1 2550399 D 585397 CDS YP_002398536.1 218690324 7139458 2551424..2552137 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15778224; Product type e : enzyme; undecaprenyl pyrophosphate phosphatase 2552137 yeiU 7139458 yeiU Escherichia coli ED1a undecaprenyl pyrophosphate phosphatase YP_002398536.1 2551424 D 585397 CDS YP_002398537.1 218690325 7139461 2552549..2553115 1 NC_011745.1 by similarity, Spr seems to have peptidase activity; involved in thermoresistance; putative outer membrane lipoprotein 2553115 spr 7139461 spr Escherichia coli ED1a putative outer membrane lipoprotein YP_002398537.1 2552549 D 585397 CDS YP_002398538.1 218690326 7143833 2553296..2554852 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2554852 rtn 7143833 rtn Escherichia coli ED1a hypothetical protein YP_002398538.1 2553296 D 585397 CDS YP_002398539.1 218690327 7139463 2556749..2557843 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative oligopeptide transporter subunit; permease component of ABC superfamily 2557843 yejB 7139463 yejB Escherichia coli ED1a putative oligopeptide transporter subunit; permease component of ABC superfamily YP_002398539.1 2556749 D 585397 CDS YP_002398540.1 218690328 7139464 2557843..2558757 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative oligopeptide ABC transporter permease 2558757 yejE 7139464 yejE Escherichia coli ED1a putative oligopeptide ABC transporter permease YP_002398540.1 2557843 D 585397 CDS YP_002398541.1 218690329 7143791 2558870..2560459 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative oligopeptide ABC transporter subunits ATP-binding protein 2560459 yejF 7143791 yejF Escherichia coli ED1a putative oligopeptide ABC transporter subunits ATP-binding protein YP_002398541.1 2558870 D 585397 CDS YP_002398542.1 218690330 7143953 complement(2560463..2560807) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2560807 yejG 7143953 yejG Escherichia coli ED1a hypothetical protein YP_002398542.1 2560463 R 585397 CDS YP_002398543.1 218690331 7143954 complement(2561140..2562330) 1 NC_011745.1 Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance; bicyclomycin/multidrug efflux system 2562330 bcr 7143954 bcr Escherichia coli ED1a bicyclomycin/multidrug efflux system YP_002398543.1 2561140 R 585397 CDS YP_002398544.1 218690332 7140434 complement(2562358..2563053) 1 NC_011745.1 catalyzes the synthesis pseudouridine from uracil-516 in 16S ribosomal RNA; 16S rRNA pseudouridylate synthase A 2563053 rsuA 7140434 rsuA Escherichia coli ED1a 16S rRNA pseudouridylate synthase A YP_002398544.1 2562358 R 585397 CDS YP_002398545.1 218690333 7140123 2563203..2564963 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative nucleic acid ATP-dependent helicase 2564963 yejH 7140123 yejH Escherichia coli ED1a putative nucleic acid ATP-dependent helicase YP_002398545.1 2563203 D 585397 CDS YP_002398546.1 218690334 7143955 2565088..2565372 1 NC_011745.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 2565372 rplY 7143955 rplY Escherichia coli ED1a 50S ribosomal protein L25 YP_002398546.1 2565088 D 585397 CDS YP_002398547.1 218690335 7141474 complement(2565511..2566518) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99296598, 10368163; Product type f : factor; nucleoid-associated protein NdpA 2566518 yejK 7141474 yejK Escherichia coli ED1a nucleoid-associated protein NdpA YP_002398547.1 2565511 R 585397 CDS YP_002398548.1 218690336 7143956 2566700..2566927 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2566927 yejL 7143956 yejL Escherichia coli ED1a hypothetical protein YP_002398548.1 2566700 D 585397 CDS YP_002398549.1 218690337 7143957 2566947..2568707 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase, inner membrane-associated 2568707 yejM 7143957 yejM Escherichia coli ED1a putative hydrolase, inner membrane-associated YP_002398549.1 2566947 D 585397 CDS YP_002398550.1 218690338 7142523 2569059..2570318 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; integrase from prophage 2570318 intA 7142523 intA Escherichia coli ED1a integrase from prophage YP_002398550.1 2569059 D 585397 CDS YP_002398551.1 218690339 7141183 2570396..2570647 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 2570647 7141183 ECED1_2641 Escherichia coli ED1a hypothetical protein YP_002398551.1 2570396 D 585397 CDS YP_002398552.1 218690340 7140694 2570815..2571021 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2571021 7140694 ECED1_2642 Escherichia coli ED1a hypothetical protein YP_002398552.1 2570815 D 585397 CDS YP_002398553.1 218690341 7140695 complement(2571170..2571358) 1 NC_011745.1 Evidence 6 : Doubtful CDS; Product type h : extrachromosomal origin; hypothetical protein 2571358 7140695 ECED1_2643 Escherichia coli ED1a hypothetical protein YP_002398553.1 2571170 R 585397 CDS YP_002398554.1 218690342 7140696 complement(2571401..2571592) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; putative repressor 2571592 7140696 ECED1_2644 Escherichia coli ED1a putative repressor YP_002398554.1 2571401 R 585397 CDS YP_002398555.1 218690343 7140697 2571628..2572284 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8491703; Product type h : extrachromosomal origin; putative lcd-like protein from phage origin (C-term) 2572284 7140697 ECED1_2645 Escherichia coli ED1a putative lcd-like protein from phage origin (C-term) YP_002398555.1 2571628 D 585397 CDS YP_002398556.1 218690344 7140698 2572238..2572597 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2572597 7140698 ECED1_2646 Escherichia coli ED1a hypothetical protein YP_002398556.1 2572238 D 585397 CDS YP_002398557.1 218690345 7140699 2572604..2572903 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2572903 7140699 ECED1_2647 Escherichia coli ED1a hypothetical protein YP_002398557.1 2572604 D 585397 CDS YP_002398558.1 218690346 7140700 2572885..2575041 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2575041 7140700 ECED1_2648 Escherichia coli ED1a hypothetical protein YP_002398558.1 2572885 D 585397 CDS YP_002398559.1 218690347 7140701 2575640..2576062 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative single stranded DNA-binding protein of prophage 2576062 7140701 ECED1_2649 Escherichia coli ED1a putative single stranded DNA-binding protein of prophage YP_002398559.1 2575640 D 585397 CDS YP_002398560.1 218690348 7140702 2576478..2576684 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2576684 7140702 ECED1_2650 Escherichia coli ED1a hypothetical protein YP_002398560.1 2576478 D 585397 CDS YP_002398561.1 218690349 7140703 2576684..2577739 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; major head protein from prophage 2577739 gp 7140703 gp Escherichia coli ED1a major head protein from prophage YP_002398561.1 2576684 D 585397 CDS YP_002398562.1 218690350 7143008 2577752..2578087 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative head decoration protein from prophage 2578087 7143008 ECED1_2652 Escherichia coli ED1a putative head decoration protein from prophage YP_002398562.1 2577752 D 585397 CDS YP_002398563.1 218690351 7140704 2578100..2578513 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative head-tail preconnector protein from prophage 2578513 7140704 ECED1_2653 Escherichia coli ED1a putative head-tail preconnector protein from prophage YP_002398563.1 2578100 D 585397 CDS YP_002398564.1 218690352 7140705 2579176..2579457 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2579457 7140705 ECED1_2654 Escherichia coli ED1a hypothetical protein YP_002398564.1 2579176 D 585397 CDS YP_002398565.1 218690353 7140706 2579714..2579896 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 2579896 7140706 ECED1_2655 Escherichia coli ED1a hypothetical protein YP_002398565.1 2579714 D 585397 CDS YP_002398566.1 218690354 7140707 complement(2580599..2581084) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative autotransporter outer membrane protein 2581084 7140707 ECED1_2656 Escherichia coli ED1a putative autotransporter outer membrane protein YP_002398566.1 2580599 R 585397 CDS YP_002398567.1 218690355 7140708 2581716..2582363 1 NC_011745.1 nitrate/nitrite response regulator NarP; NarP is phosphorylated by NarX and NarQ and can activate fdnG and nitrite or nitrate reductase systems; represses expression of other anaerobic genes; transcriptional regulator NarP 2582363 narP 7140708 narP Escherichia coli ED1a transcriptional regulator NarP YP_002398567.1 2581716 D 585397 CDS YP_002398568.1 218690356 7140363 complement(2582398..2583450) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 11756453, 12196152, 87260957, 91194558, 95362656, 9914305, 7635817; Product type pe : putative enzyme; heme lyase CcmH 2583450 ccmH 7140363 ccmH Escherichia coli ED1a heme lyase CcmH YP_002398568.1 2582398 R 585397 CDS YP_002398569.1 218690357 7139322 complement(2583447..2584004) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 12196152, 9716493, 9770295, 11256948, 11350062, 11843181, 7635817, 9537397; Product type e : enzyme; periplasmic thioredoxin of cytochrome c-type biogenesis 2584004 ccmG 7139322 ccmG Escherichia coli ED1a periplasmic thioredoxin of cytochrome c-type biogenesis YP_002398569.1 2583447 R 585397 CDS YP_002398570.1 218690358 7139321 complement(2584001..2585944) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 11756453, 12196152, 87260957, 8842153, 91194558, 95362656, 9716493, 7635817; Product type e : enzyme; heme lyase CcmF 2585944 ccmF 7139321 ccmF Escherichia coli ED1a heme lyase CcmF YP_002398570.1 2584001 R 585397 CDS YP_002398571.1 218690359 7139320 complement(2585941..2586420) 1 NC_011745.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane; cytochrome c-type biogenesis protein CcmE 2586420 ccmE 7139320 ccmE Escherichia coli ED1a cytochrome c-type biogenesis protein CcmE YP_002398571.1 2585941 R 585397 CDS YP_002398572.1 218690360 7139319 complement(2586417..2586626) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 12196152, 95362656, 9716493, 7635817; Product type f : factor; cytochrome c biogenesis protein 2586626 ccmD 7139319 ccmD Escherichia coli ED1a cytochrome c biogenesis protein YP_002398572.1 2586417 R 585397 CDS YP_002398573.1 218690361 7139318 complement(2586623..2587360) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 12196152, 14532274, 21413853, 95362656, 7635817; Product type t : transporter; heme ABC transporter membrane protein 2587360 ccmC 7139318 ccmC Escherichia coli ED1a heme ABC transporter membrane protein YP_002398573.1 2586623 R 585397 CDS YP_002398574.1 218690362 7139317 complement(2587402..2588064) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 12196152, 95362656, 9716493, 7635817; Product type t : transporter; heme ABC transporter membrane protein 2588064 ccmB 7139317 ccmB Escherichia coli ED1a heme ABC transporter membrane protein YP_002398574.1 2587402 R 585397 CDS YP_002398575.1 218690363 7139316 complement(2588061..2588684) 1 NC_011745.1 ATP-binding protein; required for proper cytochrome c maturation; cytochrome c biogenesis protein CcmA 2588684 ccmA 7139316 ccmA Escherichia coli ED1a cytochrome c biogenesis protein CcmA YP_002398575.1 2588061 R 585397 CDS YP_002398576.1 218690364 7139315 complement(2588697..2589299) 1 NC_011745.1 with NapABDFGH functions as a nitrate reductase; NapC functions as an electron shuttle between NapAB and NapGH or quinone; cytochrome c-type protein NapC 2589299 napC 7139315 napC Escherichia coli ED1a cytochrome c-type protein NapC YP_002398576.1 2588697 R 585397 CDS YP_002398577.1 218690365 7140352 complement(2589309..2589758) 1 NC_011745.1 small subunit of periplasmic nitrate reductase; receives electrons from the membrane-bound NapC and passes them to NapA; citrate reductase cytochrome c-type subunit 2589758 napB 7140352 napB Escherichia coli ED1a citrate reductase cytochrome c-type subunit YP_002398577.1 2589309 R 585397 CDS YP_002398578.1 218690366 7140351 complement(2589755..2590618) 1 NC_011745.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; quinol dehydrogenase membrane component 2590618 napH 7140351 napH Escherichia coli ED1a quinol dehydrogenase membrane component YP_002398578.1 2589755 R 585397 CDS YP_002398579.1 218690367 7140356 complement(2590605..2591300) 1 NC_011745.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway; quinol dehydrogenase periplasmic component 2591300 napG 7140356 napG Escherichia coli ED1a quinol dehydrogenase periplasmic component YP_002398579.1 2590605 R 585397 CDS YP_002398580.1 218690368 7140355 complement(2591307..2593793) 1 NC_011745.1 periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC; nitrate reductase catalytic subunit 2593793 napA 7140355 napA Escherichia coli ED1a nitrate reductase catalytic subunit YP_002398580.1 2591307 R 585397 CDS YP_002398581.1 218690369 7140350 complement(2593790..2594053) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96228696, 99395037; Product type f : factor; assembly protein for periplasmic nitrate reductase 2594053 napD 7140350 napD Escherichia coli ED1a assembly protein for periplasmic nitrate reductase YP_002398581.1 2593790 R 585397 CDS YP_002398582.1 218690370 7140353 complement(2594043..2594537) 1 NC_011745.1 Predicted role in electron transfer to the periplasmic nitrate reductase protein NapA.; ferredoxin-type protein 2594537 napF 7140353 napF Escherichia coli ED1a ferredoxin-type protein YP_002398582.1 2594043 R 585397 CDS YP_002398583.1 218690371 7140354 2594637..2594810 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2594810 7140354 ECED1_2674 Escherichia coli ED1a hypothetical protein YP_002398583.1 2594637 D 585397 CDS YP_002398584.1 218690372 7140709 2594945..2595433 1 NC_011745.1 serine protease inhibitor, inhibits trypsin and other proteases; ecotin 2595433 eco 7140709 eco Escherichia coli ED1a ecotin YP_002398584.1 2594945 D 585397 CDS YP_002398585.1 218690373 7139769 complement(2595583..2597229) 1 NC_011745.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; malate:quinone oxidoreductase 2597229 mqo 7139769 mqo Escherichia coli ED1a malate:quinone oxidoreductase YP_002398585.1 2595583 R 585397 CDS YP_002398586.1 218690374 7139018 complement(2597447..2599090) 1 NC_011745.1 efflux pump for the antibacterial peptide microcin J25; multidrug transporter membrane component/ATP-binding protein 2599090 yojI 7139018 yojI Escherichia coli ED1a multidrug transporter membrane component/ATP-binding protein YP_002398586.1 2597447 R 585397 CDS YP_002398587.1 218690375 7140275 complement(2599166..2599816) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12226668, 12517444, 12862460, 14527653, 87057220, 88151899, 92017669, 3536913, 3887409, 7928996; Product type e : enzyme; N1-methyladenine or N3-methylcytosine DNA lesion oxidative demethylase 2599816 alkB 7140275 alkB Escherichia coli ED1a N1-methyladenine or N3-methylcytosine DNA lesion oxidative demethylase YP_002398587.1 2599166 R 585397 CDS YP_002398588.1 218690376 7143689 complement(2599816..2600880) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91073391, 93272965, 94252990; Product type r : regulator; fused DNA-binding transcriptional dual regulator ; O6-methylguanine-DNA methyltransferase 2600880 ada 7143689 ada Escherichia coli ED1a fused DNA-binding transcriptional dual regulator ; O6-methylguanine-DNA methyltransferase YP_002398588.1 2599816 R 585397 CDS YP_002398589.1 218690377 7143657 complement(2600954..2602009) 1 NC_011745.1 catalyzes the conversion of aminoimidazole ribotide to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine moiety of thiamine; involved in the maintenance and/or assembly of sulfur clusters; periplasmic lipoporotein anchored to the inner membrane; part of the thiamine pyrophosphate biosynthesis pathway; thiamine biosynthesis lipoprotein ApbE 2602009 yojL 7143657 yojL Escherichia coli ED1a thiamine biosynthesis lipoprotein ApbE YP_002398589.1 2600954 R 585397 CDS YP_002398590.1 218690378 7140276 complement(2602121..2603248) 1 NC_011745.1 allows for ions and hydrophilic solutes to cross the outer membrane; outer membrane porin protein C 2603248 ompC 7140276 ompC Escherichia coli ED1a outer membrane porin protein C YP_002398590.1 2602121 R 585397 CDS YP_002398591.1 218690379 7138983 2603987..2606659 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11758943, 12864862, 21206231, 2404948, 7984428; Product type r : regulator; phosphotransfer intermediate protein in two-component regulatory system with RcsBC 2606659 rcsD 7138983 rcsD Escherichia coli ED1a phosphotransfer intermediate protein in two-component regulatory system with RcsBC YP_002398591.1 2603987 D 585397 CDS YP_002398592.1 218690380 7143439 2606676..2607326 1 NC_011745.1 two-component response regulator RscB regulates the genes involved in capsule biosynthesis and cell division; probably phosphorylated by RcsC or RcsF; transcriptional regulator RcsB 2607326 rcsB 7143439 rcsB Escherichia coli ED1a transcriptional regulator RcsB YP_002398592.1 2606676 D 585397 CDS YP_002398593.1 218690381 7141264 complement(2607412..2610213) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11758943, 12864862, 14651646, 20032358, 21450811, 88227838, 90130299, 92048476, 9209051, 2404948, 8366025; Product type r : regulator; hybrid sensory kinase in two-component regulatory system with RcsB and YojN 2610213 rcsC 7141264 rcsC Escherichia coli ED1a hybrid sensory kinase in two-component regulatory system with RcsB and YojN YP_002398593.1 2607412 R 585397 CDS YP_002398594.1 218690382 7141265 2610428..2612254 1 NC_011745.1 with AtoC is a member of a two-component regulatory system involved in the transcriptional regulation of the ato genes for acetoacetate metabolism; sensory histidine kinase AtoS 2612254 atoS 7141265 atoS Escherichia coli ED1a sensory histidine kinase AtoS YP_002398594.1 2610428 D 585397 CDS YP_002398595.1 218690383 7140407 2612251..2613636 1 NC_011745.1 with AtoS is a two-component regulatory system involved in the transcriptional regulation of the ato genes for acetoacetate metabolism; acetoacetate metabolism regulatory protein AtoC 2613636 atoC 7140407 atoC Escherichia coli ED1a acetoacetate metabolism regulatory protein AtoC YP_002398595.1 2612251 D 585397 CDS YP_002398596.1 218690384 7142661 2613832..2614494 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 73032600, 87083402; Product type c : carrier; acetyl-CoA:acetoacetyl-CoA transferase subunit alpha 2614494 atoD 7142661 atoD Escherichia coli ED1a acetyl-CoA:acetoacetyl-CoA transferase subunit alpha YP_002398596.1 2613832 D 585397 CDS YP_002398597.1 218690385 7141944 2614494..2615144 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 73032600, 87083402; Product type c : carrier; acetyl-CoA:acetoacetyl-CoA transferase subunit beta 2615144 atoA 7141944 atoA Escherichia coli ED1a acetyl-CoA:acetoacetyl-CoA transferase subunit beta YP_002398597.1 2614494 D 585397 CDS YP_002398598.1 218690386 7142659 2615134..2615295 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 2615295 7142659 ECED1_2689 Escherichia coli ED1a hypothetical protein YP_002398598.1 2615134 D 585397 CDS YP_002398599.1 218690387 7144034 2615141..2616463 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 73032600, 87083402; Product type t : transporter; short chain fatty acid transporter 2616463 atoE 7144034 atoE Escherichia coli ED1a short chain fatty acid transporter YP_002398599.1 2615141 D 585397 CDS YP_002398600.1 218690388 7140406 2616494..2617678 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 73032600, 87083402; Product type c : carrier; acetyl-CoA acetyltransferase 2617678 atoB 7140406 atoB Escherichia coli ED1a acetyl-CoA acetyltransferase YP_002398600.1 2616494 D 585397 CDS YP_002398601.1 218690389 7142660 complement(2617752..2618528) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2618528 yfaP 7142660 yfaP Escherichia coli ED1a hypothetical protein YP_002398601.1 2617752 R 585397 CDS YP_002398602.1 218690390 7143964 complement(2618533..2620182) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2620182 yfaQ 7143964 yfaQ Escherichia coli ED1a hypothetical protein YP_002398602.1 2618533 R 585397 CDS YP_002398603.1 218690391 7143965 complement(2620183..2624802) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative large extracellular alpha-helical protein 2624802 7143965 ECED1_2694 Escherichia coli ED1a putative large extracellular alpha-helical protein YP_002398603.1 2620183 R 585397 CDS YP_002398604.1 218690392 7143872 complement(2624721..2625344) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2625344 yfaT 7143872 yfaT Escherichia coli ED1a hypothetical protein YP_002398604.1 2624721 R 585397 CDS YP_002398605.1 218690393 7143966 complement(2625341..2627029) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2627029 yfaA 7143966 yfaA Escherichia coli ED1a hypothetical protein YP_002398605.1 2625341 R 585397 CDS YP_002398606.1 218690394 7143959 complement(2627178..2629805) 1 NC_011745.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 2629805 gyrA 7143959 gyrA Escherichia coli ED1a DNA gyrase subunit A YP_002398606.1 2627178 R 585397 CDS YP_002398607.1 218690395 7139852 2629952..2630674 1 NC_011745.1 Involved in ubiquinone biosynthesis; 3-demethylubiquinone-9 3-methyltransferase 2630674 ubiG 7139852 ubiG Escherichia coli ED1a 3-demethylubiquinone-9 3-methyltransferase YP_002398607.1 2629952 D 585397 CDS YP_002398608.1 218690396 7140862 complement(2630814..2634578) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15659678; Product type f : factor; adhesin 2634578 yfaL 7140862 yfaL Escherichia coli ED1a adhesin YP_002398608.1 2630814 R 585397 CDS YP_002398609.1 218690397 7143962 2635254..2637539 1 NC_011745.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 2637539 nrdA 7143962 nrdA Escherichia coli ED1a ribonucleotide-diphosphate reductase subunit alpha YP_002398609.1 2635254 D 585397 CDS YP_002398610.1 218690398 7139919 2637729..2638859 1 NC_011745.1 B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA; ribonucleotide-diphosphate reductase subunit beta 2638859 nrdB 7139919 nrdB Escherichia coli ED1a ribonucleotide-diphosphate reductase subunit beta YP_002398610.1 2637729 D 585397 CDS YP_002398611.1 218690399 7139920 2638859..2639113 1 NC_011745.1 plays a role in maintenance and possibly the biosynthesis of diferric-tyrosyl radical cofactor, essential for nucleotide reduction catalyzed by ribonucleotide reductases; 2Fe-2S ferredoxin YfaE 2639113 yfaE 7139920 yfaE Escherichia coli ED1a 2Fe-2S ferredoxin YfaE YP_002398611.1 2638859 D 585397 CDS YP_002398612.1 218690400 7143961 complement(2639167..2639817) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 92165728, 1537798, 6087316; hypothetical protein 2639817 inaA 7143961 inaA Escherichia coli ED1a hypothetical protein YP_002398612.1 2639167 R 585397 CDS YP_002398613.1 218690401 7141108 complement(2640020..2641096) 1 NC_011745.1 hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic; glycerophosphodiester phosphodiesterase 2641096 glpQ 7141108 glpQ Escherichia coli ED1a glycerophosphodiester phosphodiesterase YP_002398613.1 2640020 R 585397 CDS YP_002398614.1 218690402 7142974 complement(2641101..2642459) 1 NC_011745.1 catalyzes the uptake of glycerol-3-phosphate into the cell with the simultaneous export of inorganic phosphate from the cell; sn-glycerol-3-phosphate transporter 2642459 glpT 7142974 glpT Escherichia coli ED1a sn-glycerol-3-phosphate transporter YP_002398614.1 2641101 R 585397 CDS YP_002398615.1 218690403 7142976 2642732..2644360 1 NC_011745.1 anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor; sn-glycerol-3-phosphate dehydrogenase subunit A 2644360 glpA 7142976 glpA Escherichia coli ED1a sn-glycerol-3-phosphate dehydrogenase subunit A YP_002398615.1 2642732 D 585397 CDS YP_002398616.1 218690404 7142966 2644350..2645609 1 NC_011745.1 sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters; anaerobic glycerol-3-phosphate dehydrogenase subunit B 2645609 glpB 7142966 glpB Escherichia coli ED1a anaerobic glycerol-3-phosphate dehydrogenase subunit B YP_002398616.1 2644350 D 585397 CDS YP_002398617.1 218690405 7142967 2645606..2646796 1 NC_011745.1 anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate; sn-glycerol-3-phosphate dehydrogenase subunit C 2646796 glpC 7142967 glpC Escherichia coli ED1a sn-glycerol-3-phosphate dehydrogenase subunit C YP_002398617.1 2645606 D 585397 CDS YP_002398618.1 218690406 7142968 2646989..2647900 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2647900 yfaD 7142968 yfaD Escherichia coli ED1a hypothetical protein YP_002398618.1 2646989 D 585397 CDS YP_002398619.1 218690407 7143960 2647910..2648134 1 NC_011745.1 Evidence 7 : Gene remnant; hypothetical protein 2648134 ypaA 7143960 ypaA Escherichia coli ED1a hypothetical protein YP_002398619.1 2647910 D 585397 CDS YP_002398620.1 218690408 7140277 complement(2648175..2648978) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12454498, 16511168, 8550403; Product type pe : putative enzyme; putative aldolase 2648978 yfaU 7140277 yfaU Escherichia coli ED1a putative aldolase YP_002398620.1 2648175 R 585397 CDS YP_002398621.1 218690409 7143967 complement(2648996..2650285) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative carboxylate transporter; phthalate permease family 2650285 yfaV 7143967 yfaV Escherichia coli ED1a putative carboxylate transporter; phthalate permease family YP_002398621.1 2648996 R 585397 CDS YP_002398622.1 218690410 7143968 complement(2650342..2651559) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative epimerase/enolase/dehydratase 2651559 yfaW 7143968 yfaW Escherichia coli ED1a putative epimerase/enolase/dehydratase YP_002398622.1 2650342 R 585397 CDS YP_002398623.1 218690411 7143969 complement(2651562..2652344) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 2652344 yfaX 7143969 yfaX Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002398623.1 2651562 R 585397 CDS YP_002398624.1 218690412 7143970 complement(2652564..2653766) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; competence damage-inducible protein A 2653766 yfaY 7143970 yfaY Escherichia coli ED1a competence damage-inducible protein A YP_002398624.1 2652564 R 585397 CDS YP_002398625.1 218690413 7143971 complement(2653866..2654408) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative outer membrane porin protein 2654408 yfaZ 7143971 yfaZ Escherichia coli ED1a putative outer membrane porin protein YP_002398625.1 2653866 R 585397 CDS YP_002398626.1 218690414 7143972 2654687..2655112 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16430214; Product type pe : putative enzyme; putative NUDIX hydrolase 2655112 yfaO 7143972 yfaO Escherichia coli ED1a putative NUDIX hydrolase YP_002398626.1 2654687 D 585397 CDS YP_002398627.1 218690415 7143963 complement(2655151..2655753) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2655753 ais 7143963 ais Escherichia coli ED1a hypothetical protein YP_002398627.1 2655151 R 585397 CDS YP_002398628.1 218690416 7143684 2656043..2657200 1 NC_011745.1 catalyzes the conversion of UDP-4-keto-arabinose to UDP-4-amino-4-deoxy-L-arabinose; UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase 2657200 yfbE 7143684 yfbE Escherichia coli ED1a UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase YP_002398628.1 2656043 D 585397 CDS YP_002398629.1 218690417 7143974 2657204..2658172 1 NC_011745.1 catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate; undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase 2658172 yfbF 7143974 yfbF Escherichia coli ED1a undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase YP_002398629.1 2657204 D 585397 CDS YP_002398630.1 218690418 7143975 2658172..2660154 1 NC_011745.1 Bifunctional polymyxin resistance arnA protein; catalyzes the decarboxylation of UDP-glucuronic acid to UDP-4-keto-arabinose and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose to form UDP-L-4-formamido-arabinose; active in certain mutant strains; bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase 2660154 yfbG 7143975 yfbG Escherichia coli ED1a bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase YP_002398630.1 2658172 D 585397 CDS YP_002398631.1 218690419 7143976 2660151..2661041 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2661041 yfbH 7143976 yfbH Escherichia coli ED1a hypothetical protein YP_002398631.1 2660151 D 585397 CDS YP_002398632.1 218690420 7143977 2661041..2662693 1 NC_011745.1 catalyzes the addition of 4-amino-4-deoxy-L-arabinose to lipid A; 4-amino-4-deoxy-L-arabinose transferase 2662693 arnT 7143977 arnT Escherichia coli ED1a 4-amino-4-deoxy-L-arabinose transferase YP_002398632.1 2661041 D 585397 CDS YP_002398633.1 218690421 7142622 2662690..2663025 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2663025 yfbW 7142622 yfbW Escherichia coli ED1a hypothetical protein YP_002398633.1 2662690 D 585397 CDS YP_002398634.1 218690422 7143988 2662743..2663411 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2663411 yfbJ 7143988 yfbJ Escherichia coli ED1a hypothetical protein YP_002398634.1 2662743 D 585397 CDS YP_002398635.1 218690423 7143978 complement(2663405..2663671) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96015440, 15569938; Product type pt : putative transporter; polymyxin resistance protein B 2663671 pmrD 7143978 pmrD Escherichia coli ED1a polymyxin resistance protein B YP_002398635.1 2663405 R 585397 CDS YP_002398636.1 218690424 7139074 complement(2663781..2665136) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96186953, 8626063; Product type e : enzyme; O-succinylbenzoic acid--CoA ligase 2665136 menE 7139074 menE Escherichia coli ED1a O-succinylbenzoic acid--CoA ligase YP_002398636.1 2663781 R 585397 CDS YP_002398637.1 218690425 7142245 complement(2665133..2666095) 1 NC_011745.1 catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase 2666095 menC 7142245 menC Escherichia coli ED1a O-succinylbenzoate synthase YP_002398637.1 2665133 R 585397 CDS YP_002398638.1 218690426 7142243 complement(2666095..2666952) 1 NC_011745.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase 2666952 menB 7142243 menB Escherichia coli ED1a naphthoate synthase YP_002398638.1 2666095 R 585397 CDS YP_002398639.1 218690427 7142242 complement(2666967..2667725) 1 NC_011745.1 catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; acyl-CoA thioester hydrolase YfbB 2667725 yfbB 7142242 yfbB Escherichia coli ED1a acyl-CoA thioester hydrolase YfbB YP_002398639.1 2666967 R 585397 CDS YP_002398640.1 218690428 7143973 complement(2667722..2669392) 1 NC_011745.1 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase 2669392 menD 7143973 menD Escherichia coli ED1a 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase YP_002398640.1 2667722 R 585397 CDS YP_002398641.1 218690429 7142244 complement(2669481..2670776) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9150206, 96140724, 2666397, 7984428, 8549818, 8764478; Product type e : enzyme; isochorismate synthase 2 2670776 menF 7142244 menF Escherichia coli ED1a isochorismate synthase 2 YP_002398641.1 2669481 R 585397 CDS YP_002398642.1 218690430 7142246 complement(2670855..2671160) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2671160 elaB 7142246 elaB Escherichia coli ED1a hypothetical protein YP_002398642.1 2670855 R 585397 CDS YP_002398643.1 218690431 7139782 complement(2671215..2671676) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 2671676 elaA 7139782 elaA Escherichia coli ED1a hypothetical protein YP_002398643.1 2671215 R 585397 CDS YP_002398644.1 218690432 7139781 2671741..2672658 1 NC_011745.1 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 2672658 elaC 7139781 elaC Escherichia coli ED1a ribonuclease Z YP_002398644.1 2671741 D 585397 CDS YP_002398645.1 218690433 7139783 complement(2672779..2674521) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2674521 yfbK 7139783 yfbK Escherichia coli ED1a hypothetical protein YP_002398645.1 2672779 R 585397 CDS YP_002398646.1 218690434 7143979 2674659..2675630 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-associated peptidase 2675630 yfbL 7143979 yfbL Escherichia coli ED1a putative membrane-associated peptidase YP_002398646.1 2674659 D 585397 CDS YP_002398647.1 218690435 7143980 2675733..2676236 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2676236 yfbM 7143980 yfbM Escherichia coli ED1a hypothetical protein YP_002398647.1 2675733 D 585397 CDS YP_002398648.1 218690436 7143981 complement(2676303..2677760) 1 NC_011745.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit N 2677760 nuoN 7143981 nuoN Escherichia coli ED1a NADH dehydrogenase subunit N YP_002398648.1 2676303 R 585397 CDS YP_002398649.1 218690437 7139956 complement(2677767..2679296) 1 NC_011745.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit M 2679296 nuoM 7139956 nuoM Escherichia coli ED1a NADH dehydrogenase subunit M YP_002398649.1 2677767 R 585397 CDS YP_002398650.1 218690438 7139955 complement(2679460..2681301) 1 NC_011745.1 Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit L 2681301 nuoL 7139955 nuoL Escherichia coli ED1a NADH dehydrogenase subunit L YP_002398650.1 2679460 R 585397 CDS YP_002398651.1 218690439 7139954 complement(2681298..2681600) 1 NC_011745.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit K 2681600 nuoK 7139954 nuoK Escherichia coli ED1a NADH dehydrogenase subunit K YP_002398651.1 2681298 R 585397 CDS YP_002398652.1 218690440 7139953 complement(2681597..2682151) 1 NC_011745.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit J 2682151 nuoJ 7139953 nuoJ Escherichia coli ED1a NADH dehydrogenase subunit J YP_002398652.1 2681597 R 585397 CDS YP_002398653.1 218690441 7139952 complement(2682163..2682705) 1 NC_011745.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I 2682705 nuoI 7139952 nuoI Escherichia coli ED1a NADH dehydrogenase subunit I YP_002398653.1 2682163 R 585397 CDS YP_002398654.1 218690442 7139951 complement(2682720..2683697) 1 NC_011745.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit H 2683697 nuoH 7139951 nuoH Escherichia coli ED1a NADH dehydrogenase subunit H YP_002398654.1 2682720 R 585397 CDS YP_002398655.1 218690443 7139950 complement(2683694..2686426) 1 NC_011745.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit G 2686426 nuoG 7139950 nuoG Escherichia coli ED1a NADH dehydrogenase subunit G YP_002398655.1 2683694 R 585397 CDS YP_002398656.1 218690444 7139949 complement(2686473..2687810) 1 NC_011745.1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase; NADH dehydrogenase I subunit F 2687810 nuoF 7139949 nuoF Escherichia coli ED1a NADH dehydrogenase I subunit F YP_002398656.1 2686473 R 585397 CDS YP_002398657.1 218690445 7139948 complement(2687807..2688307) 1 NC_011745.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit E 2688307 nuoE 7139948 nuoE Escherichia coli ED1a NADH dehydrogenase subunit E YP_002398657.1 2687807 R 585397 CDS YP_002398658.1 218690446 7139947 complement(2688310..2690112) 1 NC_011745.1 NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms; bifunctional NADH:ubiquinone oxidoreductase subunit C/D 2690112 nuoC 7139947 nuoC Escherichia coli ED1a bifunctional NADH:ubiquinone oxidoreductase subunit C/D YP_002398658.1 2688310 R 585397 CDS YP_002398659.1 218690447 7139946 complement(2690206..2690868) 1 NC_011745.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B 2690868 nuoB 7139946 nuoB Escherichia coli ED1a NADH dehydrogenase subunit B YP_002398659.1 2690206 R 585397 CDS YP_002398660.1 218690448 7139945 complement(2690884..2691327) 1 NC_011745.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit A 2691327 nuoA 7139945 nuoA Escherichia coli ED1a NADH dehydrogenase subunit A YP_002398660.1 2690884 R 585397 CDS YP_002398661.1 218690449 7139944 complement(2691957..2692895) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12123461, 9882671, 7565112; Product type r : regulator; DNA-binding transcriptional repressor of flagellar, motility and chemotaxis genes 2692895 lrhA 7139944 lrhA Escherichia coli ED1a DNA-binding transcriptional repressor of flagellar, motility and chemotaxis genes YP_002398661.1 2691957 R 585397 CDS YP_002398662.1 218690450 7141925 2693815..2695032 1 NC_011745.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase AlaT 2695032 yfbQ 7141925 yfbQ Escherichia coli ED1a aminotransferase AlaT YP_002398662.1 2693815 D 585397 CDS YP_002398663.1 218690451 7143982 2695116..2695715 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15489502; Product type e : enzyme; hypothetical protein 2695715 yfbR 7143982 yfbR Escherichia coli ED1a hypothetical protein YP_002398663.1 2695116 D 585397 CDS YP_002398664.1 218690452 7143983 complement(2695774..2697606) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 2697606 yfbS 7143983 yfbS Escherichia coli ED1a putative transporter YP_002398664.1 2695774 R 585397 CDS YP_002398665.1 218690453 7143984 complement(2697693..2698343) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphatase 2698343 yfbT 7143984 yfbT Escherichia coli ED1a putative phosphatase YP_002398665.1 2697693 R 585397 CDS YP_002398666.1 218690454 7143985 complement(2698354..2698848) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2698848 yfbU 7143985 yfbU Escherichia coli ED1a hypothetical protein YP_002398666.1 2698354 R 585397 CDS YP_002398667.1 218690455 7143986 complement(2698931..2699386) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2699386 yfbV 7143986 yfbV Escherichia coli ED1a hypothetical protein YP_002398667.1 2698931 R 585397 CDS YP_002398668.1 218690456 7143987 2699724..2700926 1 NC_011745.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 2700926 ackA 7143987 ackA Escherichia coli ED1a acetate kinase YP_002398668.1 2699724 D 585397 CDS YP_002398669.1 218690457 7143641 2701001..2703145 1 NC_011745.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 2703145 pta 7143641 pta Escherichia coli ED1a phosphate acetyltransferase YP_002398669.1 2701001 D 585397 CDS YP_002398670.1 218690458 7141201 2703335..2704855 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pc : putative carrier; hypothetical protein 2704855 yfcC 7141201 yfcC Escherichia coli ED1a hypothetical protein YP_002398670.1 2703335 D 585397 CDS YP_002398671.1 218690459 7143990 complement(2704889..2705431) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16430214; Product type pe : putative enzyme; putative NUDIX hydrolase 2705431 yfcD 7143990 yfcD Escherichia coli ED1a putative NUDIX hydrolase YP_002398671.1 2704889 R 585397 CDS YP_002398672.1 218690460 7143991 complement(2705489..2706043) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; phosphodiesterase 2706043 yfcE 7143991 yfcE Escherichia coli ED1a phosphodiesterase YP_002398672.1 2705489 R 585397 CDS YP_002398673.1 218690461 7143992 complement(2706096..2706740) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 2706740 yfcF 7143992 yfcF Escherichia coli ED1a hypothetical protein YP_002398673.1 2706096 R 585397 CDS YP_002398674.1 218690462 7143993 2706876..2707523 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; glutathione S-transferase 2707523 yfcG 7143993 yfcG Escherichia coli ED1a glutathione S-transferase YP_002398674.1 2706876 D 585397 CDS YP_002398675.1 218690463 7143994 2707580..2707942 1 NC_011745.1 catalyzes the formation of dihydromonapterin triphosphate from dihydroneopterin triphosphate; D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase 2707942 folX 7143994 folX Escherichia coli ED1a D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase YP_002398675.1 2707580 D 585397 CDS YP_002398676.1 218690464 7142163 2707963..2708856 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pe : putative enzyme; hypothetical protein 2708856 yfcH 7142163 yfcH Escherichia coli ED1a hypothetical protein YP_002398676.1 2707963 D 585397 CDS YP_002398677.1 218690465 7143995 complement(2708904..2709794) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transposase 2709794 yfcI 7143995 yfcI Escherichia coli ED1a putative transposase YP_002398677.1 2708904 R 585397 CDS YP_002398678.1 218690466 7143996 complement(2709990..2710763) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10373434, 3313284, 91060556; Product type t : transporter; histidine/lysine/arginine/ornithine transporter subunit 2710763 hisP 7143996 hisP Escherichia coli ED1a histidine/lysine/arginine/ornithine transporter subunit YP_002398678.1 2709990 R 585397 CDS YP_002398679.1 218690467 7139898 complement(2710771..2711487) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10373434, 3313284; Product type t : transporter; histidine/lysine/arginine/ornithine ABC transporter membrane protein 2711487 hisM 7139898 hisM Escherichia coli ED1a histidine/lysine/arginine/ornithine ABC transporter membrane protein YP_002398679.1 2710771 R 585397 CDS YP_002398680.1 218690468 7139897 complement(2711484..2712170) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10373434; Product type t : transporter; histidine/lysine/arginine/ornithine ABC transporter membrane protein 2712170 hisQ 7139897 hisQ Escherichia coli ED1a histidine/lysine/arginine/ornithine ABC transporter membrane protein YP_002398680.1 2711484 R 585397 CDS YP_002398681.1 218690469 7139899 complement(2712260..2713042) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10373434, 6449635, 8161536, 9298646, 9600841, 9740056; Product type t : transporter; histidine/lysine/arginine/ornithine ABC transporter subunit periplasmic-binding protein 2713042 hisJ 7139899 hisJ Escherichia coli ED1a histidine/lysine/arginine/ornithine ABC transporter subunit periplasmic-binding protein YP_002398681.1 2712260 R 585397 CDS YP_002398682.1 218690470 7139895 complement(2713263..2714045) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 4583243, 87308226, 3040734, 9298646; Product type t : transporter; lysine/arginine/ornithine ABC transporter subunit periplasmic-binding protein 2714045 argT 7139895 argT Escherichia coli ED1a lysine/arginine/ornithine ABC transporter subunit periplasmic-binding protein YP_002398682.1 2713263 R 585397 CDS YP_002398683.1 218690471 7142621 complement(2714311..2714880) 1 NC_011745.1 catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 2714880 ubiX 7142621 ubiX Escherichia coli ED1a 3-octaprenyl-4-hydroxybenzoate carboxy-lyase YP_002398683.1 2714311 R 585397 CDS YP_002398684.1 218690472 7140864 complement(2714975..2716492) 1 NC_011745.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 2716492 purF 7140864 purF Escherichia coli ED1a amidophosphoribosyltransferase YP_002398684.1 2714975 R 585397 CDS YP_002398685.1 218690473 7141218 complement(2716529..2717017) 1 NC_011745.1 membrane protein required for colicin V production; colicin V production protein 2717017 cvpA 7141218 cvpA Escherichia coli ED1a colicin V production protein YP_002398685.1 2716529 R 585397 CDS YP_002398686.1 218690474 7142091 complement(2717367..2718029) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3040734; hypothetical protein 2718029 dedD 7142091 dedD Escherichia coli ED1a hypothetical protein YP_002398686.1 2717367 R 585397 CDS YP_002398687.1 218690475 7143084 complement(2718019..2719287) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3040739, 91112811, 92041808, 1989505, 3040734; Product type e : enzyme; bifunctional folylpolyglutamate synthase/ dihydrofolate synthase 2719287 folC 7143084 folC Escherichia coli ED1a bifunctional folylpolyglutamate synthase/ dihydrofolate synthase YP_002398687.1 2718019 R 585397 CDS YP_002398688.1 218690476 7142157 complement(2719357..2720271) 1 NC_011745.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta 2720271 accD 7142157 accD Escherichia coli ED1a acetyl-CoA carboxylase subunit beta YP_002398688.1 2719357 R 585397 CDS YP_002398689.1 218690477 7143635 complement(2720427..2721086) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3029016, 3040734, 7678242; Product type pm : putative membrane component; hypothetical protein 2721086 dedA 7143635 dedA Escherichia coli ED1a hypothetical protein YP_002398689.1 2720427 R 585397 CDS YP_002398690.1 218690478 7143083 complement(2721169..2721981) 1 NC_011745.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 2721981 truA 7143083 truA Escherichia coli ED1a tRNA pseudouridine synthase A YP_002398690.1 2721169 R 585397 CDS YP_002398691.1 218690479 7140827 complement(2721981..2722994) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 92380957, 92380982, 93123150, 2681152, 2991861, 3029016; Product type pe : putative enzyme; putative semialdehyde dehydrogenase 2722994 usg 7140827 usg Escherichia coli ED1a putative semialdehyde dehydrogenase YP_002398691.1 2721981 R 585397 CDS YP_002398692.1 218690480 7139143 complement(2723060..2724196) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90036695, 91035267, 2681152, 2991861, 3029016; Product type e : enzyme; erythronate-4-phosphate dehydrogenase 2724196 pdxB 7139143 pdxB Escherichia coli ED1a erythronate-4-phosphate dehydrogenase YP_002398692.1 2723060 R 585397 CDS YP_002398693.1 218690481 7144053 2724295..2725290 1 NC_011745.1 in Salmonella typhimurium Flk regulates flagellar biosynthesis by inhibition of the flagellar-associated type III secretion system; lowers secretion levels of the anti-sigma28 factor FlgM to the periplasm; inner membrane-anchored protein; flagella biosynthesis regulator 2725290 flk 7144053 flk Escherichia coli ED1a flagella biosynthesis regulator YP_002398693.1 2724295 D 585397 CDS YP_002398694.1 218690482 7142150 complement(2725287..2726465) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; hypothetical protein 2726465 yfcJ 7142150 yfcJ Escherichia coli ED1a hypothetical protein YP_002398694.1 2725287 R 585397 CDS YP_002398695.1 218690483 7143997 complement(2726730..2727950) 1 NC_011745.1 FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase I 2727950 fabB 7143997 fabB Escherichia coli ED1a 3-oxoacyl-(acyl carrier protein) synthase I YP_002398695.1 2726730 R 585397 CDS YP_002398696.1 218690484 7139838 2728109..2730115 1 NC_011745.1 catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules; 5-methylaminomethyl-2-thiouridine methyltransferase 2730115 mnmC 7139838 mnmC Escherichia coli ED1a 5-methylaminomethyl-2-thiouridine methyltransferase YP_002398696.1 2728109 D 585397 CDS YP_002398697.1 218690485 7140814 complement(2730236..2730514) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2730514 yfcL 7140814 yfcL Escherichia coli ED1a hypothetical protein YP_002398697.1 2730236 R 585397 CDS YP_002398698.1 218690486 7143998 complement(2730548..2731096) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2731096 yfcM 7143998 yfcM Escherichia coli ED1a hypothetical protein YP_002398698.1 2730548 R 585397 CDS YP_002398699.1 218690487 7143999 complement(2731096..2731905) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2731905 yfcA 7143999 yfcA Escherichia coli ED1a hypothetical protein YP_002398699.1 2731096 R 585397 CDS YP_002398700.1 218690488 7143989 complement(2731905..2732729) 1 NC_011745.1 D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm; penicillin-insensitive murein endopeptidase 2732729 mepA 7143989 mepA Escherichia coli ED1a penicillin-insensitive murein endopeptidase YP_002398700.1 2731905 R 585397 CDS YP_002398701.1 218690489 7142247 complement(2732733..2733818) 1 NC_011745.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 2733818 aroC 7142247 aroC Escherichia coli ED1a chorismate synthase YP_002398701.1 2732733 R 585397 CDS YP_002398702.1 218690490 7142625 complement(2733853..2734785) 1 NC_011745.1 involved in methylation of ribosomal protein L3; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 2734785 prmB 7142625 prmB Escherichia coli ED1a N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase YP_002398702.1 2733853 R 585397 CDS YP_002398703.1 218690491 7139125 2734951..2735502 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2735502 yfcN 7139125 yfcN Escherichia coli ED1a hypothetical protein YP_002398703.1 2734951 D 585397 CDS YP_002398704.1 218690492 7144000 complement(2735826..2736683) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2736683 7144000 ECED1_2796 Escherichia coli ED1a hypothetical protein YP_002398704.1 2735826 R 585397 CDS YP_002398705.1 218690493 7143873 complement(2736670..2737197) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative exported fimbrial-like adhesin protein 2737197 yfcP 7143873 yfcP Escherichia coli ED1a putative exported fimbrial-like adhesin protein YP_002398705.1 2736670 R 585397 CDS YP_002398706.1 218690494 7144001 complement(2737194..2737673) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin exported protein 2737673 yfcQ 7144001 yfcQ Escherichia coli ED1a putative fimbrial-like adhesin exported protein YP_002398706.1 2737194 R 585397 CDS YP_002398707.1 218690495 7144002 complement(2737670..2738239) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin exported protein 2738239 yfcR 7144002 yfcR Escherichia coli ED1a putative fimbrial-like adhesin exported protein YP_002398707.1 2737670 R 585397 CDS YP_002398708.1 218690496 7144003 complement(2738190..2738942) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative periplasmic pilus exported chaperone 2738942 yfcS 7144003 yfcS Escherichia coli ED1a putative periplasmic pilus exported chaperone YP_002398708.1 2738190 R 585397 CDS YP_002398709.1 218690497 7144004 complement(2738962..2741616) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative export usher protein 2741616 yfcU 7144004 yfcU Escherichia coli ED1a putative export usher protein YP_002398709.1 2738962 R 585397 CDS YP_002398710.1 218690498 7144005 complement(2741691..2742257) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin exported protein 2742257 yfcV 7144005 yfcV Escherichia coli ED1a putative fimbrial-like adhesin exported protein YP_002398710.1 2741691 R 585397 CDS YP_002398711.1 218690499 7144006 complement(2742824..2743309) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10089421, 20200300, 9489669; Product type e : enzyme; phosphohistidine phosphatase 2743309 sixA 7144006 sixA Escherichia coli ED1a phosphohistidine phosphatase YP_002398711.1 2742824 R 585397 CDS YP_002398712.1 218690500 7143802 complement(2743512..2745656) 1 NC_011745.1 multifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities: forms a heterotetramer with FadI; similar to FadA2B2 complex; involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate; multifunctional fatty acid oxidation complex subunit alpha 2745656 fadJ 7143802 fadJ Escherichia coli ED1a multifunctional fatty acid oxidation complex subunit alpha YP_002398712.1 2743512 R 585397 CDS YP_002398713.1 218690501 7144007 complement(2745656..2746966) 1 NC_011745.1 FadI; fatty acid oxidation complex component beta; functions in a heterotetramer with FadJ; similar to FadA2B2 complex; functions in beta-oxidation of fatty acids during anaerobic growth; 3-ketoacyl-CoA thiolase 2746966 fadI 7144007 fadI Escherichia coli ED1a 3-ketoacyl-CoA thiolase YP_002398713.1 2745656 R 585397 CDS YP_002398714.1 218690502 7144008 complement(2747148..2747432) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2747432 yfcZ 7144008 yfcZ Escherichia coli ED1a hypothetical protein YP_002398714.1 2747148 R 585397 CDS YP_002398715.1 218690503 7144009 2747798..2749144 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15178802, 2840553, 3286621, 91100327, 1987139, 9119048; Product type t : transporter; long-chain fatty acid outer membrane transporter 2749144 fadL 7144009 fadL Escherichia coli ED1a long-chain fatty acid outer membrane transporter YP_002398715.1 2747798 D 585397 CDS YP_002398716.1 218690504 7144129 complement(2749206..2749961) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8145644, 15352239; Product type lp : lipoprotein; putative lipoprotein 2749961 vacJ 7144129 vacJ Escherichia coli ED1a putative lipoprotein YP_002398716.1 2749206 R 585397 CDS YP_002398717.1 218690505 7139164 complement(2749987..2750157) 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 2750157 7139164 ECED1_2809 Escherichia coli ED1a hypothetical protein YP_002398717.1 2749987 R 585397 CDS YP_002398718.1 218690506 7143874 2750255..2751187 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2751187 yfdC 7143874 yfdC Escherichia coli ED1a hypothetical protein YP_002398718.1 2750255 D 585397 CDS YP_002398719.1 218690507 7141409 complement(2751437..2752372) 1 NC_011745.1 regulates the synthesis and expression of the dsdXA operon and dadA gene; DNA-binding transcriptional regulator DsdC 2752372 dsdC 7141409 dsdC Escherichia coli ED1a DNA-binding transcriptional regulator DsdC YP_002398719.1 2751437 R 585397 CDS YP_002398720.1 218690508 7140526 2752590..2753927 1 NC_011745.1 member of the Gnt family of gluconate transporters; not involved in gluconate transport; unknown function; permease DsdX 2753927 dsdX 7140526 dsdX Escherichia coli ED1a permease DsdX YP_002398720.1 2752590 D 585397 CDS YP_002398721.1 218690509 7140527 2753945..2755273 1 NC_011745.1 catalyzes the formation of pyruvate from serine; D-serine dehydratase 2755273 dsdA 7140527 dsdA Escherichia coli ED1a D-serine dehydratase YP_002398721.1 2753945 D 585397 CDS YP_002398722.1 218690510 7140525 complement(2755381..2756919) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20378313; Product type pt : putative transporter; putative multidrug efflux system 2756919 emrY 7140525 emrY Escherichia coli ED1a putative multidrug efflux system YP_002398722.1 2755381 R 585397 CDS YP_002398723.1 218690511 7139790 complement(2756919..2758082) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20378313; Product type t : transporter; EmrKY-TolC multidrug resistance efflux pump, membrane fusion protein component 2758082 emrK 7139790 emrK Escherichia coli ED1a EmrKY-TolC multidrug resistance efflux pump, membrane fusion protein component YP_002398723.1 2756919 R 585397 CDS YP_002398724.1 218690512 7139789 2758498..2759112 1 NC_011745.1 response regulator in two-component regulatory system with EvgS; phosphorylated EvgA activates ompC, emrKY, gadABC, hdeAB and others genes; involved in acid resistance, osmotic adaption, and drug resistance; DNA-binding transcriptional activator EvgA 2759112 evgA 7139789 evgA Escherichia coli ED1a DNA-binding transcriptional activator EvgA YP_002398724.1 2758498 D 585397 CDS YP_002398725.1 218690513 7139828 2759117..2762710 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14523115, 93173621, 9501520, 10923791, 1289796, 8125343, 9535079; Product type r : regulator; hybrid sensory histidine kinase in two-component regulatory system with EvgA 2762710 evgS 7139828 evgS Escherichia coli ED1a hybrid sensory histidine kinase in two-component regulatory system with EvgA YP_002398725.1 2759117 D 585397 CDS YP_002398726.1 218690514 7139829 complement(2762766..2763911) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 2763911 yfdE 7139829 yfdE Escherichia coli ED1a hypothetical protein YP_002398726.1 2762766 R 585397 CDS YP_002398727.1 218690515 7144011 complement(2763985..2764929) 1 NC_011745.1 member of the AEC family of auxin efflux transporters; unknown function; putative transporter YfdV 2764929 yfdV 7144011 yfdV Escherichia coli ED1a putative transporter YfdV YP_002398727.1 2763985 R 585397 CDS YP_002398728.1 218690516 7144014 complement(2764999..2766693) 1 NC_011745.1 catalyzes the formation of formyl-CoA from oxalyl-CoA; putative oxalyl-CoA decarboxylase 2766693 oxc 7144014 oxc Escherichia coli ED1a putative oxalyl-CoA decarboxylase YP_002398728.1 2764999 R 585397 CDS YP_002398729.1 218690517 7139993 complement(2766747..2767997) 1 NC_011745.1 catalyzes the formation of oxalyl-CoA from oxalate and Formyl-CoA; formyl-coenzyme A transferase 2767997 frc 7139993 frc Escherichia coli ED1a formyl-coenzyme A transferase YP_002398729.1 2766747 R 585397 CDS YP_002398730.1 218690518 7142165 complement(2768509..2769141) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11157960; hypothetical protein 2769141 yfdX 7142165 yfdX Escherichia coli ED1a hypothetical protein YP_002398730.1 2768509 R 585397 CDS YP_002398731.1 218690519 7144015 2769436..2769711 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15183873; Product type lp : lipoprotein; putative lipoprotein 2769711 ypdI 7144015 ypdI Escherichia coli ED1a putative lipoprotein YP_002398731.1 2769436 D 585397 CDS YP_002398732.1 218690520 7140286 complement(2769788..2770030) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14727089; Product type pm : putative membrane component; hypothetical protein 2770030 yfdY 7140286 yfdY Escherichia coli ED1a hypothetical protein YP_002398732.1 2769788 R 585397 CDS YP_002398733.1 218690521 7144016 2770383..2771303 1 NC_011745.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(palmitoleoyl)-lipid IVA in cells subjected to cold shock; lipid A biosynthesis palmitoleoyl acyltransferase 2771303 ddg 7144016 ddg Escherichia coli ED1a lipid A biosynthesis palmitoleoyl acyltransferase YP_002398733.1 2770383 D 585397 CDS YP_002398734.1 218690522 7140757 complement(2771795..2773033) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; aminotransferase 2773033 yfdZ 7140757 yfdZ Escherichia coli ED1a aminotransferase YP_002398734.1 2771795 R 585397 CDS YP_002398735.1 218690523 7144017 2773410..2775107 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15522865; Product type prc : putative receptor; putative sensory kinase in two-component system with YpdB 2775107 ypdA 7144017 ypdA Escherichia coli ED1a putative sensory kinase in two-component system with YpdB YP_002398735.1 2773410 D 585397 CDS YP_002398736.1 218690524 7140278 2775104..2775859 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15522865; Product type pr : putative regulator; putative response regulator in two-component system with YpdA 2775859 ypdB 7140278 ypdB Escherichia coli ED1a putative response regulator in two-component system with YpdA YP_002398736.1 2775104 D 585397 CDS YP_002398737.1 218690525 7140279 2775872..2776729 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding protein 2776729 ypdC 7140279 ypdC Escherichia coli ED1a putative DNA-binding protein YP_002398737.1 2775872 D 585397 CDS YP_002398738.1 218690526 7140280 complement(2776732..2779227) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative fused PTS enzymes (multiphosphoryl transfer protein): Hpr component ; enzyme I component ; enzyme IIA component 2779227 ypdD 7140280 ypdD Escherichia coli ED1a putative fused PTS enzymes (multiphosphoryl transfer protein): Hpr component ; enzyme I component ; enzyme IIA component YP_002398738.1 2776732 R 585397 CDS YP_002398739.1 218690527 7140281 complement(2779252..2780289) 1 NC_011745.1 metalloprotein; exoaminopeptidase 2780289 ypdE 7140281 ypdE Escherichia coli ED1a exoaminopeptidase YP_002398739.1 2779252 R 585397 CDS YP_002398740.1 218690528 7140282 complement(2780289..2781374) 1 NC_011745.1 Xaa-Pro aminopeptidase; limited methionine aminopeptidase; aminopeptidase 2781374 ypdF 7140282 ypdF Escherichia coli ED1a aminopeptidase YP_002398740.1 2780289 R 585397 CDS YP_002398741.1 218690529 7140283 complement(2781390..2782637) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative enzyme IIC component of PTS 2782637 ypdG 7140283 ypdG Escherichia coli ED1a putative enzyme IIC component of PTS YP_002398741.1 2781390 R 585397 CDS YP_002398742.1 218690530 7140284 complement(2782659..2782985) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative enzyme IIB component of PTS 2782985 ypdH 7140284 ypdH Escherichia coli ED1a putative enzyme IIB component of PTS YP_002398742.1 2782659 R 585397 CDS YP_002398743.1 218690531 7140285 complement(2783204..2784169) 1 NC_011745.1 catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate; glucokinase 2784169 glk 7140285 glk Escherichia coli ED1a glucokinase YP_002398743.1 2783204 R 585397 CDS YP_002398744.1 218690532 7143191 2784373..2785629 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; hypothetical protein 2785629 yfeO 7143191 yfeO Escherichia coli ED1a hypothetical protein YP_002398744.1 2784373 D 585397 CDS YP_002398745.1 218690533 7144026 2785744..2786070 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2786070 ypeC 7144026 ypeC Escherichia coli ED1a hypothetical protein YP_002398745.1 2785744 D 585397 CDS YP_002398746.1 218690534 7140289 complement(2786211..2787449) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20177822, 20305051, 10712688, 10844693; Product type t : transporter; manganese transport protein MntH 2787449 mntH 7140289 mntH Escherichia coli ED1a manganese transport protein MntH YP_002398746.1 2786211 R 585397 CDS YP_002398747.1 218690535 7138994 2787785..2788987 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 374403, 8022285, 7007808, 827549, 4563236, 1512211; Product type t : transporter; nucleoside (except guanosine) transporter 2788987 nupC 7138994 nupC Escherichia coli ED1a nucleoside (except guanosine) transporter YP_002398747.1 2787785 D 585397 CDS YP_002398748.1 218690536 7144018 2790888..2791190 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS600 2791190 insM 7144018 insM Escherichia coli ED1a transposase ORF A, IS600 YP_002398748.1 2790888 D 585397 CDS YP_002398749.1 218690537 7141167 2791226..2792044 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS600 2792044 7141167 ECED1_2842 Escherichia coli ED1a transposase ORF B, IS600 YP_002398749.1 2791226 D 585397 CDS YP_002398750.1 218690538 7144019 complement(2792589..2792747) 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 2792747 7144019 ECED1_2844 Escherichia coli ED1a hypothetical protein YP_002398750.1 2792589 R 585397 CDS YP_002398751.1 218690539 7140620 2793010..2793354 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative nucleic acid-binding transcriptional regulator 2793354 yfeC 7140620 yfeC Escherichia coli ED1a putative nucleic acid-binding transcriptional regulator YP_002398751.1 2793010 D 585397 CDS YP_002398752.1 218690540 7144020 2793356..2793748 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative nucleic acid-binding transcriptional regulator 2793748 yfeD 7144020 yfeD Escherichia coli ED1a putative nucleic acid-binding transcriptional regulator YP_002398752.1 2793356 D 585397 CDS YP_002398753.1 218690541 7144021 complement(2793799..2795214) 1 NC_011745.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 2795214 gltX 7144021 gltX Escherichia coli ED1a glutamyl-tRNA synthetase YP_002398753.1 2793799 R 585397 CDS YP_002398754.1 218690542 7140573 complement(2795981..2796865) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10400599, 7007808, 2201776, 7559336; Product type r : regulator; DNA-binding transcriptional activator XapR 2796865 xapR 7140573 xapR Escherichia coli ED1a DNA-binding transcriptional activator XapR YP_002398754.1 2795981 R 585397 CDS YP_002398755.1 218690543 7139201 complement(2797117..2798373) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96032385, 7559336; Product type t : transporter; xanthosine transporter 2798373 xapB 7139201 xapB Escherichia coli ED1a xanthosine transporter YP_002398755.1 2797117 R 585397 CDS YP_002398756.1 218690544 7139200 complement(2798434..2799267) 1 NC_011745.1 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase 2799267 xapA 7139200 xapA Escherichia coli ED1a purine nucleoside phosphorylase YP_002398756.1 2798434 R 585397 CDS YP_002398757.1 218690545 7139199 2799516..2800280 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 2800280 yfeN 7139199 yfeN Escherichia coli ED1a hypothetical protein YP_002398757.1 2799516 D 585397 CDS YP_002398758.1 218690546 7144025 complement(2800319..2801245) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 2801245 yfeR 7144025 yfeR Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002398758.1 2800319 R 585397 CDS YP_002398759.1 218690547 7144027 2801335..2802333 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative sodium/bile acid symporter family (mazG-like) 2802333 yfeH 7144027 yfeH Escherichia coli ED1a putative sodium/bile acid symporter family (mazG-like) YP_002398759.1 2801335 D 585397 CDS YP_002398760.1 218690548 7144023 complement(2802330..2802548) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2802548 ypeB 7144023 ypeB Escherichia coli ED1a hypothetical protein YP_002398760.1 2802330 R 585397 CDS YP_002398761.1 218690549 7140288 complement(2802550..2804565) 1 NC_011745.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 2804565 ligA 7140288 ligA Escherichia coli ED1a NAD-dependent DNA ligase LigA YP_002398761.1 2802550 R 585397 CDS YP_002398762.1 218690550 7141885 complement(2804636..2805622) 1 NC_011745.1 interacts with cell division protein FitsZ and may be required to anchor septal ring structure; cell division protein ZipA 2805622 zipA 7141885 zipA Escherichia coli ED1a cell division protein ZipA YP_002398762.1 2804636 R 585397 CDS YP_002398763.1 218690551 7143274 2805864..2806625 1 NC_011745.1 putative role in sulfur assimilation; putative sulfate transport protein CysZ 2806625 cysZ 7143274 cysZ Escherichia coli ED1a putative sulfate transport protein CysZ YP_002398763.1 2805864 D 585397 CDS YP_002398764.1 218690552 7143048 2806810..2807781 1 NC_011745.1 CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis; cysteine synthase A 2807781 cysK 7143048 cysK Escherichia coli ED1a cysteine synthase A YP_002398764.1 2806810 D 585397 CDS YP_002398765.1 218690553 7143040 2808165..2808422 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type t : transporter; PTS system phosphohistidinoprotein-hexose phosphotransferase subunit Hpr 2808422 ptsH 7143040 ptsH Escherichia coli ED1a PTS system phosphohistidinoprotein-hexose phosphotransferase subunit Hpr YP_002398765.1 2808165 D 585397 CDS YP_002398766.1 218690554 7141209 2808467..2810194 1 NC_011745.1 Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system; phosphoenolpyruvate-protein phosphotransferase 2810194 ptsI 7141209 ptsI Escherichia coli ED1a phosphoenolpyruvate-protein phosphotransferase YP_002398766.1 2808467 D 585397 CDS YP_002398767.1 218690555 7141210 2810235..2810744 1 NC_011745.1 functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose; PTS system glucose-specific transporter subunit 2810744 crr 7141210 crr Escherichia coli ED1a PTS system glucose-specific transporter subunit YP_002398767.1 2810235 D 585397 CDS YP_002398768.1 218690556 7142058 complement(2810787..2811638) 1 NC_011745.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxal kinase 2811638 pdxK 7142058 pdxK Escherichia coli ED1a pyridoxal kinase YP_002398768.1 2810787 R 585397 CDS YP_002398769.1 218690557 7144056 2811743..2812111 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2812111 yfeK 7144056 yfeK Escherichia coli ED1a hypothetical protein YP_002398769.1 2811743 D 585397 CDS YP_002398770.1 218690558 7144024 complement(2812129..2813025) 1 NC_011745.1 catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide; cysteine synthase B 2813025 cysM 7144024 cysM Escherichia coli ED1a cysteine synthase B YP_002398770.1 2812129 R 585397 CDS YP_002398771.1 218690559 7143041 complement(2813160..2814257) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90202710, 90264334, 2188958, 7665461; Product type t : transporter; sulfate/thiosulfate transporter subunit 2814257 cysA 7143041 cysA Escherichia coli ED1a sulfate/thiosulfate transporter subunit YP_002398771.1 2813160 R 585397 CDS YP_002398772.1 218690560 7142107 complement(2814247..2815122) 1 NC_011745.1 Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import; sulfate/thiosulfate transporter permease subunit 2815122 cysW 7142107 cysW Escherichia coli ED1a sulfate/thiosulfate transporter permease subunit YP_002398772.1 2814247 R 585397 CDS YP_002398773.1 218690561 7143047 complement(2815122..2815955) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90264334, 2188958; Product type t : transporter; sulfate/thiosulfate transporter subunit 2815955 cysU 7143047 cysU Escherichia coli ED1a sulfate/thiosulfate transporter subunit YP_002398773.1 2815122 R 585397 CDS YP_002398774.1 218690562 7143046 complement(2815955..2816971) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90264335, 2188959, 9298646; Product type t : transporter; thiosulfate transporter subunit 2816971 cysP 7143046 cysP Escherichia coli ED1a thiosulfate transporter subunit YP_002398774.1 2815955 R 585397 CDS YP_002398775.1 218690563 7143043 complement(2817129..2817920) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 97385354, 2188959, 7984428, 9241368; Product type pe : putative enzyme; short chain dehydrogenase 2817920 ucpA 7143043 ucpA Escherichia coli ED1a short chain dehydrogenase YP_002398775.1 2817129 R 585397 CDS YP_002398776.1 218690564 7140865 2818200..2819096 1 NC_011745.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway; N-acetylmuramic acid-6-phosphate etherase 2819096 murQ 7140865 murQ Escherichia coli ED1a N-acetylmuramic acid-6-phosphate etherase YP_002398776.1 2818200 D 585397 CDS YP_002398777.1 218690565 7144028 2819100..2820524 1 NC_011745.1 belongs to PEP-dependent PTS system; contains the PTS EIIBC domains; involved in uptake of exogenous N-acetylmuramic acid (MurNAc); requires crr-encoded enzyme IIA-glucose component; PTS system N-acetylmuramic acid transporter subunits EIIBC 2820524 murP 7144028 murP Escherichia coli ED1a PTS system N-acetylmuramic acid transporter subunits EIIBC YP_002398777.1 2819100 D 585397 CDS YP_002398778.1 218690566 7139053 complement(2820704..2821603) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2821603 yfeX 7139053 yfeX Escherichia coli ED1a hypothetical protein YP_002398778.1 2820704 R 585397 CDS YP_002398779.1 218690567 7144029 complement(2821699..2822274) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12900013, 7764507; hypothetical protein 2822274 yfeY 7144029 yfeY Escherichia coli ED1a hypothetical protein YP_002398779.1 2821699 R 585397 CDS YP_002398780.1 218690568 7144030 complement(2822335..2822784) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2822784 yfeZ 7144030 yfeZ Escherichia coli ED1a hypothetical protein YP_002398780.1 2822335 R 585397 CDS YP_002398781.1 218690569 7144031 complement(2822771..2823196) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acetyltransferase 2823196 ypeA 7144031 ypeA Escherichia coli ED1a putative acetyltransferase YP_002398781.1 2822771 R 585397 CDS YP_002398782.1 218690570 7140287 2823410..2824279 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21348478, 6137479, 87242501, 1903834, 8300522; Product type e : enzyme; N-acetylmuramoyl-l-alanine amidase I 2824279 amiA 7140287 amiA Escherichia coli ED1a N-acetylmuramoyl-l-alanine amidase I YP_002398782.1 2823410 D 585397 CDS YP_002398783.1 218690571 7143702 2824283..2825182 1 NC_011745.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis; coproporphyrinogen III oxidase 2825182 hemF 7143702 hemF Escherichia coli ED1a coproporphyrinogen III oxidase YP_002398783.1 2824283 D 585397 CDS YP_002398784.1 218690572 7139870 complement(2825188..2826240) 1 NC_011745.1 activates the transcription of the ethanolamine utilization operon; transcriptional regulator EutR 2826240 yfeG 7139870 yfeG Escherichia coli ED1a transcriptional regulator EutR YP_002398784.1 2825188 R 585397 CDS YP_002398785.1 218690573 7144022 complement(2826286..2826786) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10464203; Product type ps : putative structure; putative ethanolaminosome structural protein with putative role in ethanolamine utilization 2826786 yffI 7144022 yffI Escherichia coli ED1a putative ethanolaminosome structural protein with putative role in ethanolamine utilization YP_002398785.1 2826286 R 585397 CDS YP_002398786.1 218690574 7142580 complement(2826877..2827458) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type ps : putative structure; putative carboxysome-related structural protein with putative role in ethanolamine utilization 2827458 eutL 7142580 eutL Escherichia coli ED1a putative carboxysome-related structural protein with putative role in ethanolamine utilization YP_002398786.1 2826877 R 585397 CDS YP_002398787.1 218690575 7139824 complement(2827468..2828355) 1 NC_011745.1 catalyzes the formation of acetaldehyde from ethanolamine; ethanolamine ammonia-lyase small subunit 2828355 eutC 7139824 eutC Escherichia coli ED1a ethanolamine ammonia-lyase small subunit YP_002398787.1 2827468 R 585397 CDS YP_002398788.1 218690576 7139818 complement(2828376..2829737) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3905806, 10464203; Product type e : enzyme; ethanolamine ammonia-lyase, large subunit, heavy chain 2829737 eutB 7139818 eutB Escherichia coli ED1a ethanolamine ammonia-lyase, large subunit, heavy chain YP_002398788.1 2828376 R 585397 CDS YP_002398789.1 218690577 7139817 complement(2829749..2831152) 1 NC_011745.1 ethanolamine utilization protein EutA; reactivating factor for ethanolamine ammonia lyase 2831152 eutA 7139817 eutA Escherichia coli ED1a reactivating factor for ethanolamine ammonia lyase YP_002398789.1 2829749 R 585397 CDS YP_002398790.1 218690578 7139816 complement(2831149..2832375) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7868611, 10464203; Product type pt : putative transporter; putative ethanolamine transporter 2832375 eutH 7139816 eutH Escherichia coli ED1a putative ethanolamine transporter YP_002398790.1 2831149 R 585397 CDS YP_002398791.1 218690579 7139821 complement(2832592..2833779) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pe : putative enzyme; putative alcohol dehydrogenase in ethanolamine utilization; ethanolaminosome 2833779 eutG 7139821 eutG Escherichia coli ED1a putative alcohol dehydrogenase in ethanolamine utilization; ethanolaminosome YP_002398791.1 2832592 R 585397 CDS YP_002398792.1 218690580 7139820 complement(2833769..2834605) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pf : putative factor; putative chaperonin, ethanolamine utilization protein 2834605 eutJ 7139820 eutJ Escherichia coli ED1a putative chaperonin, ethanolamine utilization protein YP_002398792.1 2833769 R 585397 CDS YP_002398793.1 218690581 7139823 complement(2834616..2836019) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pe : putative enzyme; putative aldehyde dehydrogenase, ethanolamine utilization protein 2836019 eutE 7139823 eutE Escherichia coli ED1a putative aldehyde dehydrogenase, ethanolamine utilization protein YP_002398793.1 2834616 R 585397 CDS YP_002398794.1 218690582 7139819 complement(2836031..2836318) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type ps : putative structure; putative carboxysome-like ethanolaminosome structural protein, ethanolamine utilization protein 2836318 cchB 7139819 cchB Escherichia coli ED1a putative carboxysome-like ethanolaminosome structural protein, ethanolamine utilization protein YP_002398794.1 2836031 R 585397 CDS YP_002398795.1 218690583 7139314 complement(2836425..2836718) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type ps : putative structure; putative carboxysome-like ethanolaminosome structural protein, ethanolamine utilization protein 2836718 cchA 7139314 cchA Escherichia coli ED1a putative carboxysome-like ethanolaminosome structural protein, ethanolamine utilization protein YP_002398795.1 2836425 R 585397 CDS YP_002398796.1 218690584 7139313 complement(2836757..2837773) 1 NC_011745.1 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; phosphotransacetylase 2837773 eutD 7139313 eutD Escherichia coli ED1a phosphotransacetylase YP_002398796.1 2836757 R 585397 CDS YP_002398797.1 218690585 7139822 complement(2837770..2838573) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pe : putative enzyme; putative cobalamin adenosyltransferase in ethanolamine utilization 2838573 eutT 7139822 eutT Escherichia coli ED1a putative cobalamin adenosyltransferase in ethanolamine utilization YP_002398797.1 2837770 R 585397 CDS YP_002398798.1 218690586 7139827 complement(2838570..2839271) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10464203; hypothetical protein 2839271 eutQ 7139827 eutQ Escherichia coli ED1a hypothetical protein YP_002398798.1 2838570 R 585397 CDS YP_002398799.1 218690587 7139826 complement(2839246..2839725) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pe : putative enzyme; putative nucleoside triphosphate hydrolase domain-containing protein 2839725 eutP 7139826 eutP Escherichia coli ED1a putative nucleoside triphosphate hydrolase domain-containing protein YP_002398799.1 2839246 R 585397 CDS YP_002398800.1 218690588 7139825 complement(2839738..2840073) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type ps : putative structure; putative carboxysome-like ethanolaminosome structural protein with putative role in ethanol utilization 2840073 ypfE 7139825 ypfE Escherichia coli ED1a putative carboxysome-like ethanolaminosome structural protein with putative role in ethanol utilization YP_002398800.1 2839738 R 585397 CDS YP_002398801.1 218690589 7140290 complement(2840366..2842645) 1 NC_011745.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; malic enzyme 2842645 maeB 7140290 maeB Escherichia coli ED1a malic enzyme YP_002398801.1 2840366 R 585397 CDS YP_002398802.1 218690590 7141942 2842934..2843884 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90230300; Product type e : enzyme; transaldolase A 2843884 talA 7141942 talA Escherichia coli ED1a transaldolase A YP_002398802.1 2842934 D 585397 CDS YP_002398803.1 218690591 7141506 2843904..2845907 1 NC_011745.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 2845907 tktB 7141506 tktB Escherichia coli ED1a transketolase YP_002398803.1 2843904 D 585397 CDS YP_002398804.1 218690592 7141560 complement(2845984..2847027) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2847027 ypfG 7141560 ypfG Escherichia coli ED1a hypothetical protein YP_002398804.1 2845984 R 585397 CDS YP_002398805.1 218690593 7140291 complement(2847153..2847728) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative NUDIX hydrolase 2847728 yffH 7140291 yffH Escherichia coli ED1a putative NUDIX hydrolase YP_002398805.1 2847153 R 585397 CDS YP_002398806.1 218690594 7144033 complement(2847796..2849775) 1 NC_011745.1 unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic); putative oxidoreductase Fe-S binding subunit 2849775 aegA 7144033 aegA Escherichia coli ED1a putative oxidoreductase Fe-S binding subunit YP_002398806.1 2847796 R 585397 CDS YP_002398807.1 218690595 7143667 2849981..2851681 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92374842, 1508040, 1528845; Product type r : regulator; nitrate/nitrite sensor protein NarQ 2851681 narQ 7143667 narQ Escherichia coli ED1a nitrate/nitrite sensor protein NarQ YP_002398807.1 2849981 D 585397 CDS YP_002398808.1 218690596 7140364 2851845..2854958 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12426336, 20158894, 21450803, 79216220, 10692383, 1644752; Product type t : transporter; aminoglycoside/multidrug efflux system 2854958 acrD 7140364 acrD Escherichia coli ED1a aminoglycoside/multidrug efflux system YP_002398808.1 2851845 D 585397 CDS YP_002398809.1 218690597 7143651 2855497..2855853 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2855853 yffB 7143651 yffB Escherichia coli ED1a hypothetical protein YP_002398809.1 2855497 D 585397 CDS YP_002398810.1 218690598 7144032 2855857..2856984 1 NC_011745.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.; succinyl-diaminopimelate desuccinylase 2856984 dapE 7144032 dapE Escherichia coli ED1a succinyl-diaminopimelate desuccinylase YP_002398810.1 2855857 D 585397 CDS YP_002398811.1 218690599 7143065 2857012..2857212 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2857212 ypfN 7143065 ypfN Escherichia coli ED1a hypothetical protein YP_002398811.1 2857012 D 585397 CDS YP_002398812.1 218690600 7140295 complement(2857293..2857991) 1 NC_011745.1 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase YpfH 2857991 ypfH 7140295 ypfH Escherichia coli ED1a esterase YpfH YP_002398812.1 2857293 R 585397 CDS YP_002398813.1 218690601 7140292 complement(2858065..2860080) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase 2860080 ypfI 7140292 ypfI Escherichia coli ED1a putative hydrolase YP_002398813.1 2858065 R 585397 CDS YP_002398814.1 218690602 7140293 complement(2860095..2860958) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2860958 ypfJ 7140293 ypfJ Escherichia coli ED1a hypothetical protein YP_002398814.1 2860095 R 585397 CDS YP_002398815.1 218690603 7140294 complement(2861126..2861839) 1 NC_011745.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 2861839 purC 7140294 purC Escherichia coli ED1a phosphoribosylaminoimidazole-succinocarboxamide synthase YP_002398815.1 2861126 R 585397 CDS YP_002398816.1 218690604 7141215 complement(2862052..2863086) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91358331, 1885529, 2120198; Product type lp : lipoprotein; lipoprotein 2863086 nlpB 7141215 nlpB Escherichia coli ED1a lipoprotein YP_002398816.1 2862052 R 585397 CDS YP_002398817.1 218690605 7140398 complement(2863103..2863981) 1 NC_011745.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 2863981 dapA 7140398 dapA Escherichia coli ED1a dihydrodipicolinate synthase YP_002398817.1 2863103 R 585397 CDS YP_002398818.1 218690606 7143062 2864127..2864699 1 NC_011745.1 negative transcriptional regulator of the gcvTHP operon; glycine cleavage system transcriptional repressor 2864699 gcvR 7143062 gcvR Escherichia coli ED1a glycine cleavage system transcriptional repressor YP_002398818.1 2864127 D 585397 CDS YP_002398819.1 218690607 7143171 2864699..2865169 1 NC_011745.1 bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine; thioredoxin-dependent thiol peroxidase 2865169 bcp 7143171 bcp Escherichia coli ED1a thioredoxin-dependent thiol peroxidase YP_002398819.1 2864699 D 585397 CDS YP_002398820.1 218690608 7140433 complement(2865268..2866329) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative permease 2866329 perM 7140433 perM Escherichia coli ED1a putative permease YP_002398820.1 2865268 R 585397 CDS YP_002398821.1 218690609 7144066 2866542..2868005 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative peptidase 2868005 yfgC 7144066 yfgC Escherichia coli ED1a putative peptidase YP_002398821.1 2866542 D 585397 CDS YP_002398822.1 218690610 7143713 2868026..2868385 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 2868385 yfgD 7143713 yfgD Escherichia coli ED1a putative oxidoreductase YP_002398822.1 2868026 D 585397 CDS YP_002398823.1 218690611 7143714 complement(2868523..2869269) 1 NC_011745.1 controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP; DNA replication initiation factor 2869269 hda 7143714 hda Escherichia coli ED1a DNA replication initiation factor YP_002398823.1 2868523 R 585397 CDS YP_002398824.1 218690612 7139858 complement(2869319..2870608) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8332529, 7721693; Product type t : transporter; uracil transporter 2870608 uraA 7139858 uraA Escherichia coli ED1a uracil transporter YP_002398824.1 2869319 R 585397 CDS YP_002398825.1 218690613 7139142 complement(2870694..2871320) 1 NC_011745.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 2871320 upp 7139142 upp Escherichia coli ED1a uracil phosphoribosyltransferase YP_002398825.1 2870694 R 585397 CDS YP_002398826.1 218690614 7139141 2871645..2872682 1 NC_011745.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 2872682 purM 7139141 purM Escherichia coli ED1a phosphoribosylaminoimidazole synthetase YP_002398826.1 2871645 D 585397 CDS YP_002398827.1 218690615 7141222 2872682..2873320 1 NC_011745.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 2873320 purN 7141222 purN Escherichia coli ED1a phosphoribosylglycinamide formyltransferase YP_002398827.1 2872682 D 585397 CDS YP_002398828.1 218690616 7141223 2873492..2875558 1 NC_011745.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase 2875558 ppk 7141223 ppk Escherichia coli ED1a polyphosphate kinase YP_002398828.1 2873492 D 585397 CDS YP_002398829.1 218690617 7139107 2875563..2877104 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93107072, 94025037, 94165003, 8212131, 8380170; Product type e : enzyme; exopolyphosphatase 2877104 ppx 7139107 ppx Escherichia coli ED1a exopolyphosphatase YP_002398829.1 2875563 D 585397 CDS YP_002398830.1 218690618 7139110 complement(2877143..2879386) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2879386 yfgF 7139110 yfgF Escherichia coli ED1a hypothetical protein YP_002398830.1 2877143 R 585397 CDS YP_002398831.1 218690619 7143715 complement(2879615..2879893) 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 2879893 7143715 ECED1_2928 Escherichia coli ED1a hypothetical protein YP_002398831.1 2879615 R 585397 CDS YP_002398832.1 218690620 7143877 2880240..2880758 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative outer membrane lipoprotein 2880758 yfgH 7143877 yfgH Escherichia coli ED1a putative outer membrane lipoprotein YP_002398832.1 2880240 D 585397 CDS YP_002398833.1 218690621 7143716 2880774..2881313 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2881313 yfgI 7143716 yfgI Escherichia coli ED1a hypothetical protein YP_002398833.1 2880774 D 585397 CDS YP_002398834.1 218690622 7143717 complement(2881408..2882985) 1 NC_011745.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 2882985 guaA 7143717 guaA Escherichia coli ED1a GMP synthase YP_002398834.1 2881408 R 585397 CDS YP_002398835.1 218690623 7139843 complement(2883054..2884520) 1 NC_011745.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 2884520 guaB 7139843 guaB Escherichia coli ED1a inosine 5'-monophosphate dehydrogenase YP_002398835.1 2883054 R 585397 CDS YP_002398836.1 218690624 7139844 2884682..2886058 1 NC_011745.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 2886058 xseA 7139844 xseA Escherichia coli ED1a exodeoxyribonuclease VII large subunit YP_002398836.1 2884682 D 585397 CDS YP_002398837.1 218690625 7139209 complement(2886127..2886396) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2886396 7139209 ECED1_2934 Escherichia coli ED1a hypothetical protein YP_002398837.1 2886127 R 585397 CDS YP_002398838.1 218690626 7143878 complement(2886398..2886901) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 2886901 insB 7143878 insB Escherichia coli ED1a IS1 transposase InsAB' YP_002398838.1 2886398 R 585397 CDS YP_002398839.1 218690627 7141145 complement(2886820..2887095) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; Transposase ORF A, IS1 2887095 insA 7141145 insA Escherichia coli ED1a Transposase ORF A, IS1 YP_002398839.1 2886820 R 585397 CDS YP_002398840.1 218690628 7143880 complement(2895001..2895978) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12540539; Product type pm : putative membrane component; putative outer membrane protein (sivI-like) 2895978 7143880 ECED1_2939 Escherichia coli ED1a putative outer membrane protein (sivI-like) YP_002398840.1 2895001 R 585397 CDS YP_002398841.1 218690629 7143881 complement(2896033..2897982) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8500884, 3304658, 12540539; Product type pf : putative factor; putative intimin 2897982 7143881 ECED1_2940 Escherichia coli ED1a putative intimin YP_002398841.1 2896033 R 585397 CDS YP_002398842.1 218690630 7143882 complement(2898398..2898613) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2898613 7143882 ECED1_2941 Escherichia coli ED1a hypothetical protein YP_002398842.1 2898398 R 585397 CDS YP_002398843.1 218690631 7143883 complement(2898676..2900148) 1 NC_011745.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 2900148 engA 7143883 engA Escherichia coli ED1a GTP-binding protein EngA YP_002398843.1 2898676 R 585397 CDS YP_002398844.1 218690632 7143099 complement(2900266..2901444) 1 NC_011745.1 with YaeT, YfiO, and NlpB forms a complex involved in outer membrane protein biogenesis; outer membrane protein assembly complex subunit YfgL 2901444 yfgL 7143099 yfgL Escherichia coli ED1a outer membrane protein assembly complex subunit YfgL YP_002398844.1 2900266 R 585397 CDS YP_002398845.1 218690633 7143718 complement(2901455..2902075) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2902075 yfgM 7143718 yfgM Escherichia coli ED1a hypothetical protein YP_002398845.1 2901455 R 585397 CDS YP_002398846.1 218690634 7143719 complement(2902093..2903367) 1 NC_011745.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 2903367 hisS 7143719 hisS Escherichia coli ED1a histidyl-tRNA synthetase YP_002398846.1 2902093 R 585397 CDS YP_002398847.1 218690635 7140758 complement(2903478..2904596) 1 NC_011745.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 2904596 ispG 7140758 ispG Escherichia coli ED1a 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase YP_002398847.1 2903478 R 585397 CDS YP_002398848.1 218690636 7142467 complement(2904623..2905630) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; cytoskeletal protein RodZ 2905630 yfgA 7142467 yfgA Escherichia coli ED1a cytoskeletal protein RodZ YP_002398848.1 2904623 R 585397 CDS YP_002398849.1 218690637 7143711 complement(2905915..2907069) 1 NC_011745.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N 2907069 yfgB 7143711 yfgB Escherichia coli ED1a ribosomal RNA large subunit methyltransferase N YP_002398849.1 2905915 R 585397 CDS YP_002398850.1 218690638 7143712 complement(2907219..2907650) 1 NC_011745.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 2907650 ndk 7143712 ndk Escherichia coli ED1a nucleoside diphosphate kinase YP_002398850.1 2907219 R 585397 CDS YP_002398851.1 218690639 7140372 complement(2907799..2910111) 1 NC_011745.1 penicillin-insensitive transglycosylase/transpeptidase; penicillin-binding protein 1C 2910111 pbpC 7140372 pbpC Escherichia coli ED1a penicillin-binding protein 1C YP_002398851.1 2907799 R 585397 CDS YP_002398852.1 218690640 7144046 complement(2910112..2915073) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2915073 yfhM 7144046 yfhM Escherichia coli ED1a hypothetical protein YP_002398852.1 2910112 R 585397 CDS YP_002398853.1 218690641 7143728 2915280..2916125 1 NC_011745.1 catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds; 3-mercaptopyruvate sulfurtransferase 2916125 sseA 7143728 sseA Escherichia coli ED1a 3-mercaptopyruvate sulfurtransferase YP_002398853.1 2915280 D 585397 CDS YP_002398854.1 218690642 7140760 complement(2916618..2917394) 1 NC_011745.1 enhances serine sensitivity caused by inhibition of homoserine dehydrogenase I; enhanced serine sensitivity protein SseB 2917394 sseB 7140760 sseB Escherichia coli ED1a enhanced serine sensitivity protein SseB YP_002398854.1 2916618 R 585397 CDS YP_002398855.1 218690643 7143849 complement(2917536..2918819) 1 NC_011745.1 catalyzes the removal of an N-terminal amino acid from a peptide or arylamide; aminopeptidase B 2918819 pepB 7143849 pepB Escherichia coli ED1a aminopeptidase B YP_002398855.1 2917536 R 585397 CDS YP_002398856.1 218690644 7144059 complement(2918878..2919078) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10393315; Product type pf : putative factor; hypothetical protein 2919078 yfhJ 7144059 yfhJ Escherichia coli ED1a hypothetical protein YP_002398856.1 2918878 R 585397 CDS YP_002398857.1 218690645 7143725 complement(2919090..2919425) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10393315, 20013001, 92283811, 94181532, 11551196, 1317854, 4375562, 8300516; Product type c : carrier; [2Fe-2S] ferredoxin 2919425 fdx 7143725 fdx Escherichia coli ED1a [2Fe-2S] ferredoxin YP_002398857.1 2919090 R 585397 CDS YP_002398858.1 218690646 7144146 complement(2919427..2921277) 1 NC_011745.1 involved in the maturation of iron-sulfur cluster-containing proteins; chaperone protein HscA 2921277 hscA 7144146 hscA Escherichia coli ED1a chaperone protein HscA YP_002398858.1 2919427 R 585397 CDS YP_002398859.1 218690647 7140081 complement(2921294..2921809) 1 NC_011745.1 J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins; co-chaperone HscB 2921809 hscB 7140081 hscB Escherichia coli ED1a co-chaperone HscB YP_002398859.1 2921294 R 585397 CDS YP_002398860.1 218690648 7140162 complement(2921905..2922228) 1 NC_011745.1 forms iron-sulfur clusters of ferredoxin [2FE-2S]; binds iron in the presence of the thioredoxin reductase system; forms homodimers and tetramers; similar to SufA protein; iron-sulfur cluster assembly protein 2922228 iscA 7140162 iscA Escherichia coli ED1a iron-sulfur cluster assembly protein YP_002398860.1 2921905 R 585397 CDS YP_002398861.1 218690649 7142457 complement(2922245..2922631) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10393315, 11994302, 15153099; Product type f : factor; scaffold protein 2922631 iscU 7142457 iscU Escherichia coli ED1a scaffold protein YP_002398861.1 2922245 R 585397 CDS YP_002398862.1 218690650 7142460 complement(2922659..2923873) 1 NC_011745.1 catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis; cysteine desulfurase 2923873 iscS 7142460 iscS Escherichia coli ED1a cysteine desulfurase YP_002398862.1 2922659 R 585397 CDS YP_002398863.1 218690651 7142459 complement(2923985..2924473) 1 NC_011745.1 regulates the expression of the iscRSUA operon; DNA-binding transcriptional regulator IscR 2924473 iscR 7142459 iscR Escherichia coli ED1a DNA-binding transcriptional regulator IscR YP_002398863.1 2923985 R 585397 CDS YP_002398864.1 218690652 7142458 complement(2924743..2925483) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10393315; Product type pe : putative enzyme; putative methyltransferase 2925483 yfhQ 7142458 yfhQ Escherichia coli ED1a putative methyltransferase YP_002398864.1 2924743 R 585397 CDS YP_002398865.1 218690653 7143729 2925602..2926405 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6389495, 90202735, 95095968, 10747806, 2138605, 8002619; Product type e : enzyme; inositol monophosphatase 2926405 suhB 7143729 suhB Escherichia coli ED1a inositol monophosphatase YP_002398865.1 2925602 D 585397 CDS YP_002398866.1 218690654 7141498 2926523..2927404 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative peptidase 2927404 yfhR 7141498 yfhR Escherichia coli ED1a putative peptidase YP_002398866.1 2926523 D 585397 CDS YP_002398867.1 218690655 7143730 2927595..2928875 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95020540, 96154950; Product type cp : cell process; stationary phase inducible protein CsiE 2928875 csiE 7143730 csiE Escherichia coli ED1a stationary phase inducible protein CsiE YP_002398867.1 2927595 D 585397 CDS YP_002398868.1 218690656 7142067 complement(2928867..2930006) 1 NC_011745.1 putative transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters; putative 3-phenylpropionic acid transporter 2930006 hcaT 7142067 hcaT Escherichia coli ED1a putative 3-phenylpropionic acid transporter YP_002398868.1 2928867 R 585397 CDS YP_002398869.1 218690657 7139854 2930226..2930378 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2930378 7139854 ECED1_2969 Escherichia coli ED1a hypothetical protein YP_002398869.1 2930226 D 585397 CDS YP_002398870.1 218690658 7143884 2930330..2930797 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2930797 yphA 7143884 yphA Escherichia coli ED1a hypothetical protein YP_002398870.1 2930330 D 585397 CDS YP_002398871.1 218690659 7140296 complement(2930957..2931829) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2931829 yphB 7140296 yphB Escherichia coli ED1a hypothetical protein YP_002398871.1 2930957 R 585397 CDS YP_002398872.1 218690660 7140297 complement(2931841..2932902) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase, Zn-dependent and NAD(P)-binding 2932902 yphC 7140297 yphC Escherichia coli ED1a putative oxidoreductase, Zn-dependent and NAD(P)-binding YP_002398872.1 2931841 R 585397 CDS YP_002398873.1 218690661 7140298 complement(2932968..2933966) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter membrane protein 2933966 yphD 7140298 yphD Escherichia coli ED1a putative sugar ABC transporter membrane protein YP_002398873.1 2932968 R 585397 CDS YP_002398874.1 218690662 7140299 complement(2933991..2935502) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; fused putative sugar transporter subunits of ABC superfamily: ATP-binding proteins 2935502 yphE 7140299 yphE Escherichia coli ED1a fused putative sugar transporter subunits of ABC superfamily: ATP-binding proteins YP_002398874.1 2933991 R 585397 CDS YP_002398875.1 218690663 7140300 complement(2935525..2936508) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9298646; Product type pt : putative transporter; putative sugar ABC transporter periplasmic-binding protein 2936508 yphF 7140300 yphF Escherichia coli ED1a putative sugar ABC transporter periplasmic-binding protein YP_002398875.1 2935525 R 585397 CDS YP_002398876.1 218690664 7140301 complement(2936605..2939886) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2939886 yphG 7140301 yphG Escherichia coli ED1a hypothetical protein YP_002398876.1 2936605 R 585397 CDS YP_002398877.1 218690665 7140302 2940004..2941197 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 2941197 yphH 7140302 yphH Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002398877.1 2940004 D 585397 CDS YP_002398878.1 218690666 7140303 complement(2941261..2942514) 1 NC_011745.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 2942514 glyA 7140303 glyA Escherichia coli ED1a serine hydroxymethyltransferase YP_002398878.1 2941261 R 585397 CDS YP_002398879.1 218690667 7142990 2942843..2944033 1 NC_011745.1 flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine; nitric oxide dioxygenase 2944033 hmp 7142990 hmp Escherichia coli ED1a nitric oxide dioxygenase YP_002398879.1 2942843 D 585397 CDS YP_002398880.1 218690668 7139903 complement(2944078..2944416) 1 NC_011745.1 indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; nitrogen regulatory protein P-II 1 2944416 glnB 7139903 glnB Escherichia coli ED1a nitrogen regulatory protein P-II 1 YP_002398880.1 2944078 R 585397 CDS YP_002398881.1 218690669 7143196 complement(2944477..2945811) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8226691, 8412694; Product type pr : putative regulator; putative DNA-binding response regulator in two-component system 2945811 yfhA 7143196 yfhA Escherichia coli ED1a putative DNA-binding response regulator in two-component system YP_002398881.1 2944477 R 585397 CDS YP_002398882.1 218690670 7143720 complement(2945801..2946514) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2946514 yfhG 7143720 yfhG Escherichia coli ED1a hypothetical protein YP_002398882.1 2945801 R 585397 CDS YP_002398883.1 218690671 7143723 complement(2946679..2948106) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative sensory kinase in two-component system 2948106 yfhK 7143723 yfhK Escherichia coli ED1a putative sensory kinase in two-component system YP_002398883.1 2946679 R 585397 CDS YP_002398884.1 218690672 7140761 complement(2948682..2952569) 1 NC_011745.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase 2952569 purL 7140761 purL Escherichia coli ED1a phosphoribosylformylglycinamidine synthase YP_002398884.1 2948682 R 585397 CDS YP_002398885.1 218690673 7141221 2952965..2954383 1 NC_011745.1 YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function; putative transglycosylase 2954383 yfhD 7141221 yfhD Escherichia coli ED1a putative transglycosylase YP_002398885.1 2952965 D 585397 CDS YP_002398886.1 218690674 7143722 complement(2954380..2954916) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12110595; Product type e : enzyme; tRNA-specific adenosine deaminase 2954916 tadA 7143722 tadA Escherichia coli ED1a tRNA-specific adenosine deaminase YP_002398886.1 2954380 R 585397 CDS YP_002398887.1 218690675 7141503 complement(2954941..2955576) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2955576 yfhB 7141503 yfhB Escherichia coli ED1a hypothetical protein YP_002398887.1 2954941 R 585397 CDS YP_002398888.1 218690676 7143721 2955785..2956633 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 2956633 yfhH 7143721 yfhH Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002398888.1 2955785 D 585397 CDS YP_002398889.1 218690677 7143724 2956689..2956949 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8765743, 8880900; Product type c : carrier; ferredoxin 2956949 yfhL 7143724 yfhL Escherichia coli ED1a ferredoxin YP_002398889.1 2956689 D 585397 CDS YP_002398890.1 218690678 7140158 complement(2957220..2957384) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2957384 7140158 ECED1_2991 Escherichia coli ED1a hypothetical protein YP_002398890.1 2957220 R 585397 CDS YP_002398891.1 218690679 7140159 complement(2957644..2958024) 1 NC_011745.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase 2958024 acpS 7140159 acpS Escherichia coli ED1a 4'-phosphopantetheinyl transferase YP_002398891.1 2957644 R 585397 CDS YP_002398892.1 218690680 7143647 complement(2958024..2958755) 1 NC_011745.1 involved in the de novo synthesis of pyridoxine (Vitamin B6); pyridoxine 5'-phosphate synthase 2958755 pdxJ 7143647 pdxJ Escherichia coli ED1a pyridoxine 5'-phosphate synthase YP_002398892.1 2958024 R 585397 CDS YP_002398893.1 218690681 7144055 complement(2958767..2959495) 1 NC_011745.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 2959495 recO 7144055 recO Escherichia coli ED1a DNA repair protein RecO YP_002398893.1 2958767 R 585397 CDS YP_002398894.1 218690682 7141582 complement(2959507..2960412) 1 NC_011745.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 2960412 era 7141582 era Escherichia coli ED1a GTP-binding protein Era YP_002398894.1 2959507 R 585397 CDS YP_002398895.1 218690683 7139809 complement(2960409..2961089) 1 NC_011745.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 2961089 rnc 7139809 rnc Escherichia coli ED1a ribonuclease III YP_002398895.1 2960409 R 585397 CDS YP_002398896.1 218690684 7141432 complement(2961361..2962335) 1 NC_011745.1 catalyzes the cleavage of the amino-terminal leader peptide from secretory proteins; signal peptidase I 2962335 lepB 7141432 lepB Escherichia coli ED1a signal peptidase I YP_002398896.1 2961361 R 585397 CDS YP_002398897.1 218690685 7141874 complement(2962351..2964150) 1 NC_011745.1 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 2964150 lepA 7141874 lepA Escherichia coli ED1a GTP-binding protein LepA YP_002398897.1 2962351 R 585397 CDS YP_002398898.1 218690686 7141873 complement(2964348..2964827) 1 NC_011745.1 involved in the reduction of the SoxR iron-sulfur cluster; SoxR reducing system protein RseC 2964827 rseC 7141873 rseC Escherichia coli ED1a SoxR reducing system protein RseC YP_002398898.1 2964348 R 585397 CDS YP_002398899.1 218690687 7140111 complement(2964824..2965780) 1 NC_011745.1 periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP; periplasmic negative regulator of sigmaE 2965780 rseB 7140111 rseB Escherichia coli ED1a periplasmic negative regulator of sigmaE YP_002398899.1 2964824 R 585397 CDS YP_002398900.1 218690688 7140110 complement(2965780..2966430) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9159522, 97303092, 99431977, 7768826; Product type f : factor; anti-RNA polymerase sigma factor SigE 2966430 rseA 7140110 rseA Escherichia coli ED1a anti-RNA polymerase sigma factor SigE YP_002398900.1 2965780 R 585397 CDS YP_002398901.1 218690689 7140109 complement(2966463..2967038) 1 NC_011745.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE 2967038 rpoE 7140109 rpoE Escherichia coli ED1a RNA polymerase sigma factor RpoE YP_002398901.1 2966463 R 585397 CDS YP_002398902.1 218690690 7141488 2967446..2969068 1 NC_011745.1 catalyzes the formation of oxaloacetate from L-aspartate; L-aspartate oxidase 2969068 nadB 7141488 nadB Escherichia coli ED1a L-aspartate oxidase YP_002398902.1 2967446 D 585397 CDS YP_002398903.1 218690691 7140331 complement(2969053..2969790) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative S-adenosyl-L-methionine-dependent methyltransferase 2969790 yfiC 7140331 yfiC Escherichia coli ED1a putative S-adenosyl-L-methionine-dependent methyltransferase YP_002398903.1 2969053 R 585397 CDS YP_002398904.1 218690692 7143733 2969922..2971256 1 NC_011745.1 facilitates an early step in the assembly of the 50S subunit of the ribosome; ATP-dependent RNA helicase SrmB 2971256 srmB 7143733 srmB Escherichia coli ED1a ATP-dependent RNA helicase SrmB YP_002398904.1 2969922 D 585397 CDS YP_002398905.1 218690693 7143845 complement(2971289..2972170) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 2972170 yfiE 7143845 yfiE Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002398905.1 2971289 R 585397 CDS YP_002398906.1 218690694 7143735 2972273..2972860 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12562784; Product type t : transporter; neutral amino-acid efflux protein 2972860 yfiK 7143735 yfiK Escherichia coli ED1a neutral amino-acid efflux protein YP_002398906.1 2972273 D 585397 CDS YP_002398907.1 218690695 7143738 complement(2972916..2973299) 1 NC_011745.1 stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit; autonomous glycyl radical cofactor GrcA 2973299 yfiD 7143738 yfiD Escherichia coli ED1a autonomous glycyl radical cofactor GrcA YP_002398907.1 2972916 R 585397 CDS YP_002398908.1 218690696 7143734 2973604..2974293 1 NC_011745.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 2974293 ung 7143734 ung Escherichia coli ED1a uracil-DNA glycosylase YP_002398908.1 2973604 D 585397 CDS YP_002398909.1 218690697 7139140 complement(2974341..2975378) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative methyltransferase 2975378 yfiF 7139140 yfiF Escherichia coli ED1a putative methyltransferase YP_002398909.1 2974341 R 585397 CDS YP_002398910.1 218690698 7143736 complement(2975368..2975571) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2975571 7143736 ECED1_3013 Escherichia coli ED1a hypothetical protein YP_002398910.1 2975368 R 585397 CDS YP_002398911.1 218690699 7143886 2975585..2976004 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12952960, 9388228, 99175138, 10644706; Product type c : carrier; thioredoxin 2 2976004 trxC 7143886 trxC Escherichia coli ED1a thioredoxin 2 YP_002398911.1 2975585 D 585397 CDS YP_002398912.1 218690700 7140833 2976073..2976771 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2976771 yfiP 7140833 yfiP Escherichia coli ED1a hypothetical protein YP_002398912.1 2976073 D 585397 CDS YP_002398913.1 218690701 7143743 2976803..2979463 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; fused acyl-CoA synthetase: NAD(P)-binding subunit ; ATP-binding subunit 2979463 yfiQ 7143743 yfiQ Escherichia coli ED1a fused acyl-CoA synthetase: NAD(P)-binding subunit ; ATP-binding subunit YP_002398913.1 2976803 D 585397 CDS YP_002398914.1 218690702 7143744 2979577..2980932 1 NC_011745.1 catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome; phosphatidylserine synthase 2980932 pssA 7143744 pssA Escherichia coli ED1a phosphatidylserine synthase YP_002398914.1 2979577 D 585397 CDS YP_002398915.1 218690703 7141196 2981029..2981301 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2981301 yfiM 7141196 yfiM Escherichia coli ED1a hypothetical protein YP_002398915.1 2981029 D 585397 CDS YP_002398916.1 218690704 7143740 complement(2981298..2982596) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91219460, 1709493, 2053984, 2118499, 2190187, 8419306; Product type t : transporter; alpha-ketoglutarate transporter 2982596 kgtP 7143740 kgtP Escherichia coli ED1a alpha-ketoglutarate transporter YP_002398916.1 2981298 R 585397 CDS YP_002398917.1 218690705 7142510 complement(2982758..2983261) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS1 2983261 insB 7142510 insB Escherichia coli ED1a transposase ORF B, IS1 YP_002398917.1 2982758 R 585397 CDS YP_002398918.1 218690706 7141146 complement(2983180..2983455) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF 1, IS1 2983455 insA 7141146 insA Escherichia coli ED1a transposase ORF 1, IS1 YP_002398918.1 2983180 R 585397 CDS YP_002398919.1 218690707 7141124 complement(2983716..2983952) 1 NC_011745.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; hypothetical protein 2983952 7141124 ECED1_3022 Escherichia coli ED1a hypothetical protein YP_002398919.1 2983716 R 585397 CDS YP_002398920.1 218690708 7143887 complement(2984030..2984362) 1 NC_011745.1 Evidence 7 : Gene remnant; hypothetical protein 2984362 7143887 ECED1_3023 Escherichia coli ED1a hypothetical protein YP_002398920.1 2984030 R 585397 CDS YP_002398921.1 218690709 7143888 complement(2984278..2984682) 1 NC_011745.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; hypothetical protein 2984682 7143888 ECED1_3024 Escherichia coli ED1a hypothetical protein YP_002398921.1 2984278 R 585397 CDS YP_002398922.1 218690710 7143889 complement(2984926..2985648) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group 2985648 7143889 ECED1_3025 Escherichia coli ED1a transposase ORF B, IS3 family, IS150 group YP_002398922.1 2984926 R 585397 CDS YP_002398923.1 218690711 7142817 complement(2991853..2994426) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14550559, 14640692, 91294166, 93015925, 93388583, 99428468; Product type f : factor; protein disaggregation chaperone 2994426 clpB 7142817 clpB Escherichia coli ED1a protein disaggregation chaperone YP_002398923.1 2991853 R 585397 CDS YP_002398924.1 218690712 7140160 complement(2994556..2995287) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1906060, 2066329; hypothetical protein 2995287 yfiH 7140160 yfiH Escherichia coli ED1a hypothetical protein YP_002398924.1 2994556 R 585397 CDS YP_002398925.1 218690713 7143737 complement(2995284..2996264) 1 NC_011745.1 responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase D 2996264 rluD 7143737 rluD Escherichia coli ED1a 23S rRNA pseudouridine synthase D YP_002398925.1 2995284 R 585397 CDS YP_002398926.1 218690714 7141427 2996399..2997136 1 NC_011745.1 with YaeT, NlpB and YfgL forms a complex involved in the proper assembly and/or targeting of OMPs to the outer membrane; involved in resistance to ampicillin and tetracycline; outer membrane protein assembly complex subunit YfiO 2997136 yfiO 7141427 yfiO Escherichia coli ED1a outer membrane protein assembly complex subunit YfiO YP_002398926.1 2996399 D 585397 CDS YP_002398927.1 218690715 7143742 2997406..2997747 1 NC_011745.1 associated with 30S ribosomal subunit; interferes with translation elongation; translation inhibitor protein RaiA 2997747 yfiA 7143742 yfiA Escherichia coli ED1a translation inhibitor protein RaiA YP_002398927.1 2997406 D 585397 CDS YP_002398929.1 218690717 7144082 2997997..2999157 1 NC_011745.1 catalyzing the formation of prephenate from chorismate and the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; bifunctional chorismate mutase/prephenate dehydratase 2999157 pheA 7144082 pheA Escherichia coli ED1a bifunctional chorismate mutase/prephenate dehydratase YP_002398929.1 2997997 D 585397 CDS YP_002398930.1 218690718 7144081 complement(2999200..3000321) 1 NC_011745.1 catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis; bifunctional chorismate mutase/prephenate dehydrogenase 3000321 tyrA 7144081 tyrA Escherichia coli ED1a bifunctional chorismate mutase/prephenate dehydrogenase YP_002398930.1 2999200 R 585397 CDS YP_002398931.1 218690719 7140850 complement(3000332..3001402) 1 NC_011745.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 3001402 aroF 7140850 aroF Escherichia coli ED1a phospho-2-dehydro-3-deoxyheptonate aldolase YP_002398931.1 3000332 R 585397 CDS YP_002398932.1 218690720 7142628 3001613..3001978 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6396419; hypothetical protein 3001978 yfiL 7142628 yfiL Escherichia coli ED1a hypothetical protein YP_002398932.1 3001613 D 585397 CDS YP_002398933.1 218690721 7143739 3002127..3002645 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3002645 yfiR 7143739 yfiR Escherichia coli ED1a hypothetical protein YP_002398933.1 3002127 D 585397 CDS YP_002398934.1 218690722 7143745 3002635..3003861 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; hypothetical protein 3003861 yfiN 7143745 yfiN Escherichia coli ED1a hypothetical protein YP_002398934.1 3002635 D 585397 CDS YP_002398935.1 218690723 7143741 3003877..3004359 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96032391; Product type pm : putative membrane component; putative outer membrane lipoprotein 3004359 yfiB 7143741 yfiB Escherichia coli ED1a putative outer membrane lipoprotein YP_002398935.1 3003877 D 585397 CDS YP_002398936.1 218690724 7143732 complement(3004436..3004783) 1 NC_011745.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 3004783 rplS 7143732 rplS Escherichia coli ED1a 50S ribosomal protein L19 YP_002398936.1 3004436 R 585397 CDS YP_002398937.1 218690725 7141468 complement(3004825..3005592) 1 NC_011745.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 3005592 trmD 7141468 trmD Escherichia coli ED1a tRNA (guanine-N(1)-)-methyltransferase YP_002398937.1 3004825 R 585397 CDS YP_002398938.1 218690726 7140815 complement(3005623..3006171) 1 NC_011745.1 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 3006171 rimM 7140815 rimM Escherichia coli ED1a 16S rRNA-processing protein RimM YP_002398938.1 3005623 R 585397 CDS YP_002398939.1 218690727 7141420 complement(3006190..3006438) 1 NC_011745.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 3006438 rpsP 7141420 rpsP Escherichia coli ED1a 30S ribosomal protein S16 YP_002398939.1 3006190 R 585397 CDS YP_002398940.1 218690728 7140099 complement(3006575..3007936) 1 NC_011745.1 with 4.5S RNA forms a signal recognition particle involved in targeting and integration of inner membrane proteins; signal recognition particle protein 3007936 ffh 7140099 ffh Escherichia coli ED1a signal recognition particle protein YP_002398940.1 3006575 R 585397 CDS YP_002398941.1 218690729 7144165 3008028..3008894 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3008894 ypjD 7144165 ypjD Escherichia coli ED1a hypothetical protein YP_002398941.1 3008028 D 585397 CDS YP_002398942.1 218690730 7140305 3009005..3010201 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3010201 yfjD 7140305 yfjD Escherichia coli ED1a hypothetical protein YP_002398942.1 3009005 D 585397 CDS YP_002398943.1 218690731 7143747 complement(3010256..3010849) 1 NC_011745.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 3010849 grpE 7143747 grpE Escherichia coli ED1a heat shock protein GrpE YP_002398943.1 3010256 R 585397 CDS YP_002398944.1 218690732 7143023 3010972..3011850 1 NC_011745.1 catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 3011850 ppnK 7143023 ppnK Escherichia coli ED1a inorganic polyphosphate/ATP-NAD kinase YP_002398944.1 3010972 D 585397 CDS YP_002398945.1 218690733 7143746 3011936..3013597 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87259985, 91355307, 95058623, 3037486; Product type cp : cell process; recombination and repair protein 3013597 recN 7143746 recN Escherichia coli ED1a recombination and repair protein YP_002398945.1 3011936 D 585397 CDS YP_002398946.1 218690734 7141581 3013746..3014087 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 2045357; Product type lp : lipoprotein; hypothetical protein 3014087 smpA 7141581 smpA Escherichia coli ED1a hypothetical protein YP_002398946.1 3013746 D 585397 CDS YP_002398947.1 218690735 7143811 complement(3014149..3014439) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3014439 yfjF 7143811 yfjF Escherichia coli ED1a hypothetical protein YP_002398947.1 3014149 R 585397 CDS YP_002398948.1 218690736 7143748 complement(3014429..3014905) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3014905 yfjG 7143748 yfjG Escherichia coli ED1a hypothetical protein YP_002398948.1 3014429 R 585397 CDS YP_002398949.1 218690737 7143749 3015037..3015519 1 NC_011745.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 3015519 smpB 7143749 smpB Escherichia coli ED1a SsrA-binding protein YP_002398949.1 3015037 D 585397 CDS YP_002398950.1 218690738 7143853 3016220..3016702 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 3016702 7143853 ECED1_3061 Escherichia coli ED1a hypothetical protein YP_002398950.1 3016220 D 585397 CDS YP_002398951.1 218690739 7143892 complement(3017016..3018116) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; late control gene D protein 3018116 D 7143892 D Escherichia coli ED1a late control gene D protein YP_002398951.1 3017016 R 585397 CDS YP_002398952.1 218690740 7143051 complement(3018113..3018598) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; bacteriophage tail protein GpU 3018598 U 7143051 U Escherichia coli ED1a bacteriophage tail protein GpU YP_002398952.1 3018113 R 585397 CDS YP_002398953.1 218690741 7140855 complement(3018595..3021672) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage tail tape measure protein 3021672 7140855 ECED1_3064 Escherichia coli ED1a putative phage tail tape measure protein YP_002398953.1 3018595 R 585397 CDS YP_002398954.1 218690742 7143893 complement(3021799..3022101) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage tail protein E 3022101 7143893 ECED1_3065 Escherichia coli ED1a putative phage tail protein E YP_002398954.1 3021799 R 585397 CDS YP_002398955.1 218690743 7143894 complement(3022156..3022671) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; major tail sheath protein FII 3022671 fII 7143894 fII Escherichia coli ED1a major tail sheath protein FII YP_002398955.1 3022156 R 585397 CDS YP_002398956.1 218690744 7144180 complement(3022681..3023853) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; major tail sheath protein FI 3023853 fI 7144180 fI Escherichia coli ED1a major tail sheath protein FI YP_002398956.1 3022681 R 585397 CDS YP_002398957.1 218690745 7144176 complement(3023996..3024568) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3891522, 3894006, 6310572; Product type h : extrachromosomal origin; site-specific DNA recombinase; e14 prophage 3024568 pin 7144176 pin Escherichia coli ED1a site-specific DNA recombinase; e14 prophage YP_002398957.1 3023996 R 585397 CDS YP_002398958.1 218690746 7139063 3024590..3025126 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative variable tail fiber protein from prophage (fragment) 3025126 7139063 ECED1_3069 Escherichia coli ED1a putative variable tail fiber protein from prophage (fragment) YP_002398958.1 3024590 D 585397 CDS YP_002398959.1 218690747 7143895 3025126..3025728 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative tail fiber chaperone (assembly protein); e14 prophage 3025728 tfaE 7143895 tfaE Escherichia coli ED1a putative tail fiber chaperone (assembly protein); e14 prophage YP_002398959.1 3025126 D 585397 CDS YP_002398960.1 218690748 7141536 complement(3025700..3026119) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 3026119 7141536 ECED1_3071 Escherichia coli ED1a hypothetical protein YP_002398960.1 3025700 R 585397 CDS YP_002398961.1 218690749 7143897 complement(3027534..3028139) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail protein I (GpI) 3028139 I 7143897 I Escherichia coli ED1a tail protein I (GpI) YP_002398961.1 3027534 R 585397 CDS YP_002398962.1 218690750 7140212 complement(3028132..3029079) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Baseplate assembly protein GpJ 3029079 J 7140212 J Escherichia coli ED1a Baseplate assembly protein GpJ YP_002398962.1 3028132 R 585397 CDS YP_002398963.1 218690751 7142483 complement(3029027..3029386) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Baseplate assembly protein GpW 3029386 W 7142483 W Escherichia coli ED1a Baseplate assembly protein GpW YP_002398963.1 3029027 R 585397 CDS YP_002398964.1 218690752 7139170 complement(3029383..3029961) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Baseplate assembly protein GpV 3029961 V 7139170 V Escherichia coli ED1a Baseplate assembly protein GpV YP_002398964.1 3029383 R 585397 CDS YP_002398965.1 218690753 7139163 complement(3030030..3030476) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage tail completion protein 3030476 7139163 ECED1_3077 Escherichia coli ED1a putative phage tail completion protein YP_002398965.1 3030030 R 585397 CDS YP_002398966.1 218690754 7143898 complement(3030469..3030921) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail completion protein R (GpR) 3030921 R 7143898 R Escherichia coli ED1a tail completion protein R (GpR) YP_002398966.1 3030469 R 585397 CDS YP_002398967.1 218690755 7141248 complement(3030863..3031153) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 3031153 7141248 ECED1_3079 Escherichia coli ED1a hypothetical protein YP_002398967.1 3030863 R 585397 CDS YP_002398968.1 218690756 7143899 complement(3030996..3031424) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative regulatory protein 3031424 7143899 ECED1_3080 Escherichia coli ED1a putative regulatory protein YP_002398968.1 3030996 R 585397 CDS YP_002398969.1 218690757 7143900 complement(3031421..3031870) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 3031870 7143900 ECED1_3081 Escherichia coli ED1a hypothetical protein YP_002398969.1 3031421 R 585397 CDS YP_002398970.1 218690758 7143901 complement(3031800..3032312) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; putative lysozyme protein R of prophage 3032312 R 7143901 R Escherichia coli ED1a putative lysozyme protein R of prophage YP_002398970.1 3031800 R 585397 CDS YP_002398971.1 218690759 7141249 complement(3032293..3032508) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative secretory protein 3032508 7141249 ECED1_3083 Escherichia coli ED1a putative secretory protein YP_002398971.1 3032293 R 585397 CDS YP_002398972.1 218690760 7143902 complement(3032512..3032715) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; phage tail protein X (GpX) 3032715 X 7143902 X Escherichia coli ED1a phage tail protein X (GpX) YP_002398972.1 3032512 R 585397 CDS YP_002398973.1 218690761 7139198 complement(3032715..3033242) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; head completion/stabilization protein (GpL) 3033242 L 7139198 L Escherichia coli ED1a head completion/stabilization protein (GpL) YP_002398973.1 3032715 R 585397 CDS YP_002398974.1 218690762 7141706 complement(3033275..3033925) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; terminase, endonuclease subunit (GpM) 3033925 M 7141706 M Escherichia coli ED1a terminase, endonuclease subunit (GpM) YP_002398974.1 3033275 R 585397 CDS YP_002398975.1 218690763 7141938 complement(3033929..3034987) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor capsid protein H1 and H2, major capsid protein N* 3034987 N 7141938 N Escherichia coli ED1a minor capsid protein H1 and H2, major capsid protein N* YP_002398975.1 3033929 R 585397 CDS YP_002398976.1 218690764 7140328 complement(3035004..3035837) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; putative capsid scaffolding protein GpO 3035837 O 7140328 O Escherichia coli ED1a putative capsid scaffolding protein GpO YP_002398976.1 3035004 R 585397 CDS YP_002398977.1 218690765 7139963 3035980..3037746 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; terminase, ATPase subunit (GpP) 3037746 P 7139963 P Escherichia coli ED1a terminase, ATPase subunit (GpP) YP_002398977.1 3035980 D 585397 CDS YP_002398978.1 218690766 7139997 3037743..3038780 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage portal protein 3038780 7139997 ECED1_3090 Escherichia coli ED1a putative phage portal protein YP_002398978.1 3037743 D 585397 CDS YP_002398979.1 218690767 7143903 complement(3038818..3039666) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3039666 7143903 ECED1_3091 Escherichia coli ED1a hypothetical protein YP_002398979.1 3038818 R 585397 CDS YP_002398980.1 218690768 7143904 complement(3039676..3040338) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative repressor protein from prophage 3040338 7143904 ECED1_3092 Escherichia coli ED1a putative repressor protein from prophage YP_002398980.1 3039676 R 585397 CDS YP_002398981.1 218690769 7143905 complement(3040358..3041167) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 3041167 7143905 ECED1_3093 Escherichia coli ED1a hypothetical protein YP_002398981.1 3040358 R 585397 CDS YP_002398982.1 218690770 7143906 complement(3041531..3041836) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative DinI-like damage-inducible protein 3041836 7143906 ECED1_3094 Escherichia coli ED1a putative DinI-like damage-inducible protein YP_002398982.1 3041531 R 585397 CDS YP_002398983.1 218690771 7143908 complement(3042117..3042473) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 3042473 7143908 ECED1_3096 Escherichia coli ED1a hypothetical protein YP_002398983.1 3042117 R 585397 CDS YP_002398984.1 218690772 7143909 complement(3042470..3044557) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative bacteriophage replication gene A protein 3044557 7143909 ECED1_3097 Escherichia coli ED1a putative bacteriophage replication gene A protein YP_002398984.1 3042470 R 585397 CDS YP_002398985.1 218690773 7143910 complement(3044554..3045483) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; site-specific DNA-methyltransferase 3045483 dam 7143910 dam Escherichia coli ED1a site-specific DNA-methyltransferase YP_002398985.1 3044554 R 585397 CDS YP_002398986.1 218690774 7143059 complement(3045587..3046090) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS1 3046090 insB 7143059 insB Escherichia coli ED1a transposase ORF B, IS1 YP_002398986.1 3045587 R 585397 CDS YP_002398987.1 218690775 7141147 complement(3046009..3046284) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF 1, IS1 3046284 insA 7141147 insA Escherichia coli ED1a transposase ORF 1, IS1 YP_002398987.1 3046009 R 585397 CDS YP_002398988.1 218690776 7141125 complement(3046335..3046547) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3046547 7141125 ECED1_3102 Escherichia coli ED1a hypothetical protein YP_002398988.1 3046335 R 585397 CDS YP_002398989.1 218690777 7143911 complement(3046484..3046711) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative DksA/TraR protein family with a zinc finger 3046711 7143911 ECED1_3103 Escherichia coli ED1a putative DksA/TraR protein family with a zinc finger YP_002398989.1 3046484 R 585397 CDS YP_002398990.1 218690778 7143912 complement(3046711..3046950) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3046950 7143912 ECED1_3104 Escherichia coli ED1a hypothetical protein YP_002398990.1 3046711 R 585397 CDS YP_002398991.1 218690779 7143913 complement(3047012..3047353) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3047353 7143913 ECED1_3105 Escherichia coli ED1a hypothetical protein YP_002398991.1 3047012 R 585397 CDS YP_002398992.1 218690780 7143914 complement(3047775..3048284) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; regulatory protein cII 3048284 cII 7143914 cII Escherichia coli ED1a regulatory protein cII YP_002398992.1 3047775 R 585397 CDS YP_002398993.1 218690781 7139357 complement(3048317..3048559) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage regulatory protein 3048559 7139357 ECED1_3107 Escherichia coli ED1a putative phage regulatory protein YP_002398993.1 3048317 R 585397 CDS YP_002398994.1 218690782 7143915 3048681..3049313 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; phage regulatory protein cI 3049313 cI 7143915 cI Escherichia coli ED1a phage regulatory protein cI YP_002398994.1 3048681 D 585397 CDS YP_002398995.1 218690783 7139355 3049316..3050332 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Integrase 3050332 int 7139355 int Escherichia coli ED1a Integrase YP_002398995.1 3049316 D 585397 CDS YP_002398996.1 218690784 7141180 3050343..3051011 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3051011 7141180 ECED1_3110 Escherichia coli ED1a hypothetical protein YP_002398996.1 3050343 D 585397 CDS YP_002398997.1 218690785 7143916 3051824..3052801 1 NC_011745.1 in Escherichia coli this gene is induced by carbon starvation and depends on sigma S and cAMP-CRP; the structure of the Gab protein shows it is a member of non-heme iron (II)-dependent oxygenase superfamily which includes clavamini acid synthases; forms homotetramers in solution; hypothetical protein 3052801 ygaT 7143916 ygaT Escherichia coli ED1a hypothetical protein YP_002398997.1 3051824 D 585397 CDS YP_002398998.1 218690786 7143759 3052821..3054089 1 NC_011745.1 catalyzed the formation of 2-ketoglutarate from 2-hydroxyglutarate; hydroxyglutarate oxidase 3054089 ygaF 7143759 ygaF Escherichia coli ED1a hydroxyglutarate oxidase YP_002398998.1 3052821 D 585397 CDS YP_002398999.1 218690787 7143755 3054112..3055560 1 NC_011745.1 catalyzes the formation of succinate from succinate semialdehyde; NADP dependent; succinate-semialdehyde dehydrogenase I 3055560 gabD 7143755 gabD Escherichia coli ED1a succinate-semialdehyde dehydrogenase I YP_002398999.1 3054112 D 585397 CDS YP_002399000.1 218690788 7143138 3055574..3056854 1 NC_011745.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; 4-aminobutyrate aminotransferase 3056854 gabT 7143138 gabT Escherichia coli ED1a 4-aminobutyrate aminotransferase YP_002399000.1 3055574 D 585397 CDS YP_002399001.1 218690789 7143140 3057091..3058491 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94127927, 9685361, 8297211; Product type t : transporter; gamma-aminobutyrate transporter 3058491 gabP 7143140 gabP Escherichia coli ED1a gamma-aminobutyrate transporter YP_002399001.1 3057091 D 585397 CDS YP_002399002.1 218690790 7143139 3058512..3059174 1 NC_011745.1 regulator of gab gene expression; DNA-binding transcriptional regulator CsiR 3059174 csiR 7143139 csiR Escherichia coli ED1a DNA-binding transcriptional regulator CsiR YP_002399002.1 3058512 D 585397 CDS YP_002399003.1 218690791 7142068 complement(3059175..3059624) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; LysM domain/BON superfamily protein 3059624 ygaU 7142068 ygaU Escherichia coli ED1a LysM domain/BON superfamily protein YP_002399003.1 3059175 R 585397 CDS YP_002399004.1 218690792 7143760 complement(3059708..3059866) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3059866 yqaE 7143760 yqaE Escherichia coli ED1a hypothetical protein YP_002399004.1 3059708 R 585397 CDS YP_002399005.1 218690793 7140308 3060049..3060348 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3060348 ygaV 7140308 ygaV Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002399005.1 3060049 D 585397 CDS YP_002399006.1 218690794 7143761 3060358..3060882 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pe : putative enzyme; hypothetical protein 3060882 ygaP 7143761 ygaP Escherichia coli ED1a hypothetical protein YP_002399006.1 3060358 D 585397 CDS YP_002399007.1 218690795 7143758 complement(3060929..3061333) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20485613, 93126121, 9643551, 98132400, 99415935, 1480493, 7961433; Product type r : regulator; DNA binding protein, nucleoid-associated 3061333 stpA 7143758 stpA Escherichia coli ED1a DNA binding protein, nucleoid-associated YP_002399007.1 3060929 R 585397 CDS YP_002399008.1 218690796 7143862 3062000..3062449 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3062449 ygaW 7143862 ygaW Escherichia coli ED1a hypothetical protein YP_002399008.1 3062000 D 585397 CDS YP_002399009.1 218690797 7143762 complement(3062486..3062830) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7961433; hypothetical protein 3062830 ygaC 7143762 ygaC Escherichia coli ED1a hypothetical protein YP_002399009.1 3062486 R 585397 CDS YP_002399010.1 218690798 7143753 3062970..3063311 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3063311 ygaM 7143753 ygaM Escherichia coli ED1a hypothetical protein YP_002399010.1 3062970 D 585397 CDS YP_002399011.1 218690799 7143757 complement(3063368..3064702) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; bifunctional aminotransaminase/GntR family transcriptional regulator 3064702 7143757 ECED1_3126 Escherichia coli ED1a bifunctional aminotransaminase/GntR family transcriptional regulator YP_002399011.1 3063368 R 585397 CDS YP_002399012.1 218690800 7143917 3064790..3065221 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3065221 7143917 ECED1_3127 Escherichia coli ED1a hypothetical protein YP_002399012.1 3064790 D 585397 CDS YP_002399013.1 218690801 7143918 3065429..3065674 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9218434, 11441020, 8820648; Product type pc : putative carrier; glutaredoxin-like protein 3065674 nrdH 7143918 nrdH Escherichia coli ED1a glutaredoxin-like protein YP_002399013.1 3065429 D 585397 CDS YP_002399014.1 218690802 7139925 3065671..3066081 1 NC_011745.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein 3066081 nrdI 7139925 nrdI Escherichia coli ED1a ribonucleotide reductase stimulatory protein YP_002399014.1 3065671 D 585397 CDS YP_002399015.1 218690803 7139926 3066054..3068198 1 NC_011745.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 3068198 nrdE 7139926 nrdE Escherichia coli ED1a ribonucleotide-diphosphate reductase subunit alpha YP_002399015.1 3066054 D 585397 CDS YP_002399016.1 218690804 7139922 3068208..3069167 1 NC_011745.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 3069167 nrdF 7139922 nrdF Escherichia coli ED1a ribonucleotide-diphosphate reductase subunit beta YP_002399016.1 3068208 D 585397 CDS YP_002399017.1 218690805 7139923 3069524..3070726 1 NC_011745.1 with ProWX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter ATP-binding subunit 3070726 proV 7139923 proV Escherichia coli ED1a glycine betaine transporter ATP-binding subunit YP_002399017.1 3069524 D 585397 CDS YP_002399018.1 218690806 7139133 3070719..3071783 1 NC_011745.1 with ProVX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter membrane protein 3071783 proW 7139133 proW Escherichia coli ED1a glycine betaine transporter membrane protein YP_002399018.1 3070719 D 585397 CDS YP_002399019.1 218690807 7139134 3071840..3072832 1 NC_011745.1 with ProVW, part of the high-affinity transport system for the osmoprotectant glycine betaine; glycine betaine transporter periplasmic subunit 3072832 proX 7139134 proX Escherichia coli ED1a glycine betaine transporter periplasmic subunit YP_002399019.1 3071840 D 585397 CDS YP_002399020.1 218690808 7139135 3073024..3074208 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16000740; Product type pt : putative transporter; putative transport protein (ousB-like) 3074208 7139135 ECED1_3135 Escherichia coli ED1a putative transport protein (ousB-like) YP_002399020.1 3073024 D 585397 CDS YP_002399021.1 218690809 7143919 3074332..3075069 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 3075069 ygaZ 7143919 ygaZ Escherichia coli ED1a putative transporter YP_002399021.1 3074332 D 585397 CDS YP_002399022.1 218690810 7143763 3075059..3075394 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3075394 ygaH 7143763 ygaH Escherichia coli ED1a hypothetical protein YP_002399022.1 3075059 D 585397 CDS YP_002399023.1 218690811 7143756 3075485..3076015 1 NC_011745.1 DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; negative regulator of the multidrug operon emrAB; transcriptional repressor MprA 3076015 mprA 7143756 mprA Escherichia coli ED1a transcriptional repressor MprA YP_002399023.1 3075485 D 585397 CDS YP_002399024.1 218690812 7139017 3076142..3077314 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21450803, 93285984, 94262163, 1409590, 8203018; Product type t : transporter; multidrug efflux system 3077314 emrA 7139017 emrA Escherichia coli ED1a multidrug efflux system YP_002399024.1 3076142 D 585397 CDS YP_002399025.1 218690813 7139785 3077331..3078869 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21450803, 93285984, 94262163, 1409590; Product type t : transporter; multidrug efflux system protein 3078869 emrB 7139785 emrB Escherichia coli ED1a multidrug efflux system protein YP_002399025.1 3077331 D 585397 CDS YP_002399026.1 218690814 7139786 complement(3078933..3079448) 1 NC_011745.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase 3079448 luxS 7139786 luxS Escherichia coli ED1a S-ribosylhomocysteinase YP_002399026.1 3078933 R 585397 CDS YP_002399027.1 218690815 7138981 complement(3079598..3081154) 1 NC_011745.1 involved in the first step of glutathione biosynthesis; glutamate--cysteine ligase 3081154 gshA 7138981 gshA Escherichia coli ED1a glutamate--cysteine ligase YP_002399027.1 3079598 R 585397 CDS YP_002399028.1 218690816 7143027 complement(3081227..3081655) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3081655 yqaA 7143027 yqaA Escherichia coli ED1a hypothetical protein YP_002399028.1 3081227 R 585397 CDS YP_002399029.1 218690817 7140306 complement(3081652..3082218) 1 NC_011745.1 YqaB; catalyzes the dephosphorylation of fructose 1-phosphate, 6-phosphogluconate and p-nitrophenyl phosphate (pNPP); presents beta-phosphoglucomutase activity at a lower extent; fructose-1-phosphatase 3082218 yqaB 7140306 yqaB Escherichia coli ED1a fructose-1-phosphatase YP_002399029.1 3081652 R 585397 CDS YP_002399030.1 218690818 7140613 complement(3083407..3083592) 1 NC_011745.1 affects carbohydrate metabolism; has regulatory role in many processes; carbon storage regulator 3083592 csrA 7140613 csrA Escherichia coli ED1a carbon storage regulator YP_002399030.1 3083407 R 585397 CDS YP_002399031.1 218690819 7142075 complement(3083827..3086457) 1 NC_011745.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 3086457 alaS 7142075 alaS Escherichia coli ED1a alanyl-tRNA synthetase YP_002399031.1 3083827 R 585397 CDS YP_002399032.1 218690820 7143685 complement(3086586..3087086) 1 NC_011745.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 3087086 recX 7143685 recX Escherichia coli ED1a recombination regulator RecX YP_002399032.1 3086586 R 585397 CDS YP_002399033.1 218690821 7141585 complement(3087155..3088216) 1 NC_011745.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 3088216 recA 7141585 recA Escherichia coli ED1a recombinase A YP_002399033.1 3087155 R 585397 CDS YP_002399034.1 218690822 7141574 complement(3088296..3088793) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; competence damage-inducible protein A 3088793 ygaD 7141574 ygaD Escherichia coli ED1a competence damage-inducible protein A YP_002399034.1 3088296 R 585397 CDS YP_002399035.1 218690823 7143754 complement(3088938..3090023) 1 NC_011745.1 membrane-bound lytic murein transglycosylase B; catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan; murein hydrolase B 3090023 mltB 7143754 mltB Escherichia coli ED1a murein hydrolase B YP_002399035.1 3088938 R 585397 CDS YP_002399036.1 218690824 7138991 3090280..3090843 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87194727, 1334233, 3553176; Product type t : transporter; PTS system glucitol/sorbitol-specific transporter subunit IIC 3090843 srlA 7138991 srlA Escherichia coli ED1a PTS system glucitol/sorbitol-specific transporter subunit IIC YP_002399036.1 3090280 D 585397 CDS YP_002399037.1 218690825 7143840 3090840..3091799 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1100602, 3553176; Product type t : transporter; PTS system glucitol/sorbitol-specific transporter subunit IIB 3091799 srlE 7143840 srlE Escherichia coli ED1a PTS system glucitol/sorbitol-specific transporter subunit IIB YP_002399037.1 3090840 D 585397 CDS YP_002399038.1 218690826 7143843 3091810..3092181 1 NC_011745.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system glucitol/sorbitol-specific transporter subunit IIA 3092181 srlB 7143843 srlB Escherichia coli ED1a PTS system glucitol/sorbitol-specific transporter subunit IIA YP_002399038.1 3091810 D 585397 CDS YP_002399039.1 218690827 7143841 3092185..3092964 1 NC_011745.1 catalyzes the conversion of sorbitol 6-phosphate into fructose 6-phosphate; sorbitol-6-phosphate dehydrogenase 3092964 srlD 7143841 srlD Escherichia coli ED1a sorbitol-6-phosphate dehydrogenase YP_002399039.1 3092185 D 585397 CDS YP_002399040.1 218690828 7143842 3093071..3093430 1 NC_011745.1 regulator for glucitol utilization; DNA-binding transcriptional activator GutM 3093430 gutM 7143842 gutM Escherichia coli ED1a DNA-binding transcriptional activator GutM YP_002399040.1 3093071 D 585397 CDS YP_002399041.1 218690829 7139850 3093497..3094270 1 NC_011745.1 regulates genes involved in glucitol utilization; DNA-binding transcriptional repressor SrlR 3094270 srlR 7139850 srlR Escherichia coli ED1a DNA-binding transcriptional repressor SrlR YP_002399041.1 3093497 D 585397 CDS YP_002399042.1 218690830 7143844 3094263..3095228 1 NC_011745.1 catalyzes the conversion of D-arabinose 5-phosphate to D-ribulose-5-phosphate; D-arabinose 5-phosphate isomerase 3095228 gutQ 7143844 gutQ Escherichia coli ED1a D-arabinose 5-phosphate isomerase YP_002399042.1 3094263 D 585397 CDS YP_002399043.1 218690831 7139851 complement(3095225..3096739) 1 NC_011745.1 Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon; anaerobic nitric oxide reductase transcription regulator 3096739 norR 7139851 norR Escherichia coli ED1a anaerobic nitric oxide reductase transcription regulator YP_002399043.1 3095225 R 585397 CDS YP_002399044.1 218690832 7140403 3096926..3098365 1 NC_011745.1 detoxifies nitric oxide using NADH; anaerobic nitric oxide reductase flavorubredoxin 3098365 norV 7140403 norV Escherichia coli ED1a anaerobic nitric oxide reductase flavorubredoxin YP_002399044.1 3096926 D 585397 CDS YP_002399045.1 218690833 7140404 3098362..3099495 1 NC_011745.1 catalyzes the reduction of the rubredoxin moiety of nitric oxide reductase; nitric oxide reductase 3099495 norW 7140404 norW Escherichia coli ED1a nitric oxide reductase YP_002399045.1 3098362 D 585397 CDS YP_002399046.1 218690834 7140475 complement(3099717..3101969) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12377778, 92255260, 8661925; Product type e : enzyme; carbamoyl phosphate phosphatase and maturation protein for [NiFe] hydrogenases 3101969 hypF 7140475 hypF Escherichia coli ED1a carbamoyl phosphate phosphatase and maturation protein for [NiFe] hydrogenases YP_002399046.1 3099717 R 585397 CDS YP_002399047.1 218690835 7140209 complement(3102122..3102649) 1 NC_011745.1 involved in electron transport from formate to hydrogen; electron transport protein HydN 3102649 hydN 7140209 hydN Escherichia coli ED1a electron transport protein HydN YP_002399047.1 3102122 R 585397 CDS YP_002399048.1 218690836 7140203 complement(3102798..3102971) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3102971 7140203 ECED1_3163 Escherichia coli ED1a hypothetical protein YP_002399048.1 3102798 R 585397 CDS YP_002399049.1 218690837 7143920 3103077..3103505 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3103505 7143920 ECED1_3164 Escherichia coli ED1a hypothetical protein YP_002399049.1 3103077 D 585397 CDS YP_002399050.1 218690838 7143921 complement(3103597..3104016) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative HTH-type transcriptional regulator ygjM 3104016 7143921 ECED1_3165 Escherichia coli ED1a putative HTH-type transcriptional regulator ygjM YP_002399050.1 3103597 R 585397 CDS YP_002399051.1 218690839 7143922 complement(3104013..3104324) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3104324 7143922 ECED1_3166 Escherichia coli ED1a hypothetical protein YP_002399051.1 3104013 R 585397 CDS YP_002399052.1 218690840 7143923 complement(3104487..3105260) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3105260 7143923 ECED1_3167 Escherichia coli ED1a hypothetical protein YP_002399052.1 3104487 R 585397 CDS YP_002399053.1 218690841 7143924 complement(3105285..3105755) 1 NC_011745.1 involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE; hydrogenase 3 maturation protease 3105755 hycI 7143924 hycI Escherichia coli ED1a hydrogenase 3 maturation protease YP_002399053.1 3105285 R 585397 CDS YP_002399054.1 218690842 7140202 complement(3105748..3106158) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92215587, 92326636, 1625581, 2187144, 7851435; Product type f : factor; protein required for maturation of hydrogenase 3 3106158 hycH 7140202 hycH Escherichia coli ED1a protein required for maturation of hydrogenase 3 YP_002399054.1 3105748 R 585397 CDS YP_002399055.1 218690843 7140201 complement(3106155..3106922) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90251163, 92215587, 92326636, 2187144; Product type e : enzyme; hydrogenase 3 and formate hydrogenase complex subunit HycG 3106922 hycG 7140201 hycG Escherichia coli ED1a hydrogenase 3 and formate hydrogenase complex subunit HycG YP_002399055.1 3106155 R 585397 CDS YP_002399056.1 218690844 7140200 complement(3106922..3107464) 1 NC_011745.1 electron transfer protein for hydrogenase-3; the formate hydrogenlyase complex comprises of a formate dehydrogenase, unidentified electron carriers and hydrogenase-3; in this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate; formate hydrogenlyase complex iron-sulfur subunit 3107464 hycF 7140200 hycF Escherichia coli ED1a formate hydrogenlyase complex iron-sulfur subunit YP_002399056.1 3106922 R 585397 CDS YP_002399057.1 218690845 7140199 complement(3107474..3109183) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92215587, 92326636, 94170785, 2187144, 8125094; Product type e : enzyme; hydrogenase 3, large subunit 3109183 hycE 7140199 hycE Escherichia coli ED1a hydrogenase 3, large subunit YP_002399057.1 3107474 R 585397 CDS YP_002399058.1 218690846 7140198 complement(3109201..3110124) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90251163, 92215587, 92326636; Product type m : membrane component; hydrogenase 3, membrane subunit 3110124 hycD 7140198 hycD Escherichia coli ED1a hydrogenase 3, membrane subunit YP_002399058.1 3109201 R 585397 CDS YP_002399059.1 218690847 7140197 complement(3110127..3111953) 1 NC_011745.1 catalyzes the oxidation of formate to carbon dioxide and molecular hydrogen; formate hydrogenlyase comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (subunit 3); formate hydrogenlyase subunit 3 3111953 hycC 7140197 hycC Escherichia coli ED1a formate hydrogenlyase subunit 3 YP_002399059.1 3110127 R 585397 CDS YP_002399060.1 218690848 7140196 complement(3111950..3112561) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90251163, 92215587, 92326636, 2187144; Product type c : carrier; hydrogenase 3, Fe-S subunit 3112561 hycB 7140196 hycB Escherichia coli ED1a hydrogenase 3, Fe-S subunit YP_002399060.1 3111950 R 585397 CDS YP_002399061.1 218690849 7140195 complement(3112686..3113147) 1 NC_011745.1 regulates several genes involved in the formate hydrogenlyase system; seems to prevent binding of FhlA transcriptional activator to the activator sequence of hyc operon; formate hydrogenlyase regulatory protein HycA 3113147 hycA 7140195 hycA Escherichia coli ED1a formate hydrogenlyase regulatory protein HycA YP_002399061.1 3112686 R 585397 CDS YP_002399062.1 218690850 7140194 3113359..3113709 1 NC_011745.1 plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein 3113709 hypA 7140194 hypA Escherichia coli ED1a hydrogenase nickel incorporation protein YP_002399062.1 3113359 D 585397 CDS YP_002399063.1 218690851 7140204 3113713..3114585 1 NC_011745.1 GTP hydrolase involved in nickel liganding into hydrogenases; hydrogenase nickel incorporation protein HypB 3114585 hypB 7140204 hypB Escherichia coli ED1a hydrogenase nickel incorporation protein HypB YP_002399063.1 3113713 D 585397 CDS YP_002399064.1 218690852 7140205 3114576..3114848 1 NC_011745.1 HypC; accessory protein necessary for maturation of the hydrogenase isoforms 1, 2 and 3; forms a complex with HypD, HypE, and HypF proteins, which is the site of ligand biosynthesis and attachment to the iron atom of the NiFe site in the hydrogenase; hydrogenase assembly chaperone 3114848 hypC 7140205 hypC Escherichia coli ED1a hydrogenase assembly chaperone YP_002399064.1 3114576 D 585397 CDS YP_002399065.1 218690853 7140206 3114848..3115969 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91194542, 92255260, 1849603; Product type f : factor; protein required for maturation of hydrogenases 3115969 hypD 7140206 hypD Escherichia coli ED1a protein required for maturation of hydrogenases YP_002399065.1 3114848 D 585397 CDS YP_002399066.1 218690854 7140207 3116008..3116976 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91194542, 9485446, 1849603; Product type e : enzyme; carbamoyl phosphate phosphatase, hydrogenase 3 maturation protein 3116976 hypE 7140207 hypE Escherichia coli ED1a carbamoyl phosphate phosphatase, hydrogenase 3 maturation protein YP_002399066.1 3116008 D 585397 CDS YP_002399067.1 218690855 7140208 3117050..3119128 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20307603, 21557168, 90368529, 92140045, 94018617, 2118503, 2280686; Product type r : regulator; DNA-binding transcriptional activator 3119128 fhlA 7140208 fhlA Escherichia coli ED1a DNA-binding transcriptional activator YP_002399067.1 3117050 D 585397 CDS YP_002399068.1 218690856 7144168 3119134..3119601 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative molybdenum-pterin-binding-protein 3119601 7144168 ECED1_3184 Escherichia coli ED1a putative molybdenum-pterin-binding-protein YP_002399068.1 3119134 D 585397 CDS YP_002399069.1 218690857 7143925 complement(3119640..3119984) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3119984 ygbA 7143925 ygbA Escherichia coli ED1a hypothetical protein YP_002399069.1 3119640 R 585397 CDS YP_002399070.1 218690858 7143764 3120270..3122831 1 NC_011745.1 This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 3122831 mutS 7143764 mutS Escherichia coli ED1a DNA mismatch repair protein MutS YP_002399070.1 3120270 D 585397 CDS YP_002399071.1 218690859 7139057 3122937..3123593 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9130712; Product type e : enzyme; serine/threonine-specific protein phosphatase 2 3123593 pphB 7139057 pphB Escherichia coli ED1a serine/threonine-specific protein phosphatase 2 YP_002399071.1 3122937 D 585397 CDS YP_002399072.1 218690860 7139102 complement(3123644..3124441) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3124441 ygbI 7139102 ygbI Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002399072.1 3123644 R 585397 CDS YP_002399073.1 218690861 7143766 3124607..3125515 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative NAD(P)-binding Rossmann-fold domain-containing dehydrogenase 3125515 ygbJ 7143766 ygbJ Escherichia coli ED1a putative NAD(P)-binding Rossmann-fold domain-containing dehydrogenase YP_002399073.1 3124607 D 585397 CDS YP_002399074.1 218690862 7143767 3125512..3126774 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11520622; hypothetical protein 3126774 ygbK 7143767 ygbK Escherichia coli ED1a hypothetical protein YP_002399074.1 3125512 D 585397 CDS YP_002399075.1 218690863 7143768 3126771..3127409 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative aldolase 3127409 ygbL 7143768 ygbL Escherichia coli ED1a putative aldolase YP_002399075.1 3126771 D 585397 CDS YP_002399076.1 218690864 7143769 3127414..3128190 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3128190 ygbM 7143769 ygbM Escherichia coli ED1a hypothetical protein YP_002399076.1 3127414 D 585397 CDS YP_002399077.1 218690865 7143770 3128279..3129643 1 NC_011745.1 member of the Gnt family of gluconate transporters; not involved in gluconate transport; unknown function; inner membrane permease YgbN 3129643 ygbN 7143770 ygbN Escherichia coli ED1a inner membrane permease YgbN YP_002399077.1 3128279 D 585397 CDS YP_002399078.1 218690866 7143771 complement(3129786..3130829) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative exported Zn-dependent hydrolase 3130829 7143771 ECED1_3194 Escherichia coli ED1a putative exported Zn-dependent hydrolase YP_002399078.1 3129786 R 585397 CDS YP_002399079.1 218690867 7143926 3131054..3131605 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9694845; Product type pf : putative factor; hypothetical protein 3131605 7143926 ECED1_3195 Escherichia coli ED1a hypothetical protein YP_002399079.1 3131054 D 585397 CDS YP_002399080.1 218690868 7143927 complement(3131776..3132768) 1 NC_011745.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor controls a regulon of genes required for protection against external stresses; RNA polymerase sigma factor RpoS 3132768 rpoS 7143927 rpoS Escherichia coli ED1a RNA polymerase sigma factor RpoS YP_002399080.1 3131776 R 585397 CDS YP_002399081.1 218690869 7139757 complement(3132831..3133970) 1 NC_011745.1 outer membrane lipoprotein involved in stationary-phase cell survival; similar to LppB virulence determinant from Haemophilus somnus; lipoprotein NlpD 3133970 nlpD 7139757 nlpD Escherichia coli ED1a lipoprotein NlpD YP_002399081.1 3132831 R 585397 CDS YP_002399082.1 218690870 7140400 complement(3134110..3134736) 1 NC_011745.1 catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins; protein-L-isoaspartate O-methyltransferase 3134736 pcm 7140400 pcm Escherichia coli ED1a protein-L-isoaspartate O-methyltransferase YP_002399082.1 3134110 R 585397 CDS YP_002399083.1 218690871 7144049 complement(3134730..3135491) 1 NC_011745.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate; stationary phase survival protein SurE 3135491 surE 7144049 surE Escherichia coli ED1a stationary phase survival protein SurE YP_002399083.1 3134730 R 585397 CDS YP_002399084.1 218690872 7141501 complement(3135472..3136521) 1 NC_011745.1 catalyzes the modification of U13 in tRNA(Glu); tRNA pseudouridine synthase D 3136521 truD 7141501 truD Escherichia coli ED1a tRNA pseudouridine synthase D YP_002399084.1 3135472 R 585397 CDS YP_002399085.1 218690873 7140830 complement(3136518..3136997) 1 NC_011745.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 3136997 ispF 7140830 ispF Escherichia coli ED1a 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase YP_002399085.1 3136518 R 585397 CDS YP_002399086.1 218690874 7142466 complement(3136997..3137707) 1 NC_011745.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 3137707 ispD 7142466 ispD Escherichia coli ED1a 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase YP_002399086.1 3136997 R 585397 CDS YP_002399087.1 218690875 7142464 complement(3137726..3138037) 1 NC_011745.1 forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein; cell division protein FtsB 3138037 ftsB 7142464 ftsB Escherichia coli ED1a cell division protein FtsB YP_002399087.1 3137726 R 585397 CDS YP_002399088.1 218690876 7142189 complement(3138230..3138553) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3138553 ygbE 7142189 ygbE Escherichia coli ED1a hypothetical protein YP_002399088.1 3138230 R 585397 CDS YP_002399089.1 218690877 7143765 complement(3138603..3139208) 1 NC_011745.1 converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis; adenylylsulfate kinase 3139208 cysC 7143765 cysC Escherichia coli ED1a adenylylsulfate kinase YP_002399089.1 3138603 R 585397 CDS YP_002399090.1 218690878 7142109 complement(3139208..3140635) 1 NC_011745.1 may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ; sulfate adenylyltransferase subunit 1 3140635 cysN 7142109 cysN Escherichia coli ED1a sulfate adenylyltransferase subunit 1 YP_002399090.1 3139208 R 585397 CDS YP_002399091.1 218690879 7143042 complement(3140637..3141545) 1 NC_011745.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; sulfate adenylyltransferase subunit 2 3141545 cysD 7143042 cysD Escherichia coli ED1a sulfate adenylyltransferase subunit 2 YP_002399091.1 3140637 R 585397 CDS YP_002399092.1 218690880 7142110 3141797..3142834 1 NC_011745.1 catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3; alkaline phosphatase isozyme conversion aminopeptidase 3142834 iap 7142110 iap Escherichia coli ED1a alkaline phosphatase isozyme conversion aminopeptidase YP_002399092.1 3141797 D 585397 CDS YP_002399093.1 218690881 7140214 complement(3142959..3143111) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type pm : putative membrane component; small toxic peptide 3143111 7140214 ECED1_3210 Escherichia coli ED1a small toxic peptide YP_002399093.1 3142959 R 585397 CDS YP_002399094.1 218690882 7143928 complement(3143376..3144110) 1 NC_011745.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite; phosphoadenosine phosphosulfate reductase 3144110 cysH 7143928 cysH Escherichia coli ED1a phosphoadenosine phosphosulfate reductase YP_002399094.1 3143376 R 585397 CDS YP_002399095.1 218690883 7143037 complement(3144184..3145896) 1 NC_011745.1 hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide; sulfite reductase subunit beta 3145896 cysI 7143037 cysI Escherichia coli ED1a sulfite reductase subunit beta YP_002399095.1 3144184 R 585397 CDS YP_002399096.1 218690884 7143038 complement(3145896..3147695) 1 NC_011745.1 catalyzes the reduction of sulfite to sulfide in the biosynthesis of L-cysteine from sulfate; a flavoprotein with flavin reductase activity; sulfite reductase subunit alpha 3147695 cysJ 7143038 cysJ Escherichia coli ED1a sulfite reductase subunit alpha YP_002399096.1 3145896 R 585397 CDS YP_002399097.1 218690885 7143039 3148011..3148376 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12123838; Product type e : enzyme; 6-pyruvoyl tetrahydrobiopterin synthase 3148376 ygcM 7143039 ygcM Escherichia coli ED1a 6-pyruvoyl tetrahydrobiopterin synthase YP_002399097.1 3148011 D 585397 CDS YP_002399098.1 218690886 7143775 3148454..3149725 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase with FAD/NAD(P)-binding domain 3149725 ygcN 7143775 ygcN Escherichia coli ED1a putative oxidoreductase with FAD/NAD(P)-binding domain YP_002399098.1 3148454 D 585397 CDS YP_002399099.1 218690887 7143776 3149716..3149976 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative 4Fe-4S cluster-containing protein 3149976 ygcO 7143776 ygcO Escherichia coli ED1a putative 4Fe-4S cluster-containing protein YP_002399099.1 3149716 D 585397 CDS YP_002399100.1 218690888 7143777 3149993..3150568 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative anti-terminator regulatory protein 3150568 ygcP 7143777 ygcP Escherichia coli ED1a putative anti-terminator regulatory protein YP_002399100.1 3149993 D 585397 CDS YP_002399101.1 218690889 7143778 complement(3150716..3151576) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative flavoprotein 3151576 ygcQ 7143778 ygcQ Escherichia coli ED1a putative flavoprotein YP_002399101.1 3150716 R 585397 CDS YP_002399102.1 218690890 7143779 complement(3151573..3152355) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative flavoprotein 3152355 ygcR 7143779 ygcR Escherichia coli ED1a putative flavoprotein YP_002399102.1 3151573 R 585397 CDS YP_002399103.1 218690891 7143780 complement(3152327..3153664) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 3153664 ygcS 7143780 ygcS Escherichia coli ED1a putative transporter YP_002399103.1 3152327 R 585397 CDS YP_002399104.1 218690892 7143781 complement(3153758..3155212) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative FAD containing dehydrogenase 3155212 ygcU 7143781 ygcU Escherichia coli ED1a putative FAD containing dehydrogenase YP_002399104.1 3153758 R 585397 CDS YP_002399105.1 218690893 7143782 complement(3155282..3156067) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative deoxygluconate dehydrogenase 3156067 ygcW 7143782 ygcW Escherichia coli ED1a putative deoxygluconate dehydrogenase YP_002399105.1 3155282 R 585397 CDS YP_002399106.1 218690894 7143783 3156386..3157663 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 3157663 yqcE 7143783 yqcE Escherichia coli ED1a putative transporter YP_002399106.1 3156386 D 585397 CDS YP_002399107.1 218690895 7140311 3157690..3159168 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative kinase 3159168 ygcE 7140311 ygcE Escherichia coli ED1a putative kinase YP_002399107.1 3157690 D 585397 CDS YP_002399108.1 218690896 7143772 complement(3159581..3160252) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3160252 ygcF 7143772 ygcF Escherichia coli ED1a hypothetical protein YP_002399108.1 3159581 R 585397 CDS YP_002399109.1 218690897 7143773 3160425..3161027 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3161027 7143773 ECED1_3226 Escherichia coli ED1a hypothetical protein YP_002399109.1 3160425 D 585397 CDS YP_002399110.1 218690898 7143929 3161011..3161934 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3161934 ygcG 7143929 ygcG Escherichia coli ED1a hypothetical protein YP_002399110.1 3161011 D 585397 CDS YP_002399111.1 218690899 7143774 3161949..3163097 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3163097 7143774 ECED1_3228 Escherichia coli ED1a hypothetical protein YP_002399111.1 3161949 D 585397 CDS YP_002399112.1 218690900 7143930 3163091..3163975 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3163975 7143930 ECED1_3230 Escherichia coli ED1a hypothetical protein YP_002399112.1 3163091 D 585397 CDS YP_002399113.1 218690901 7143931 3163785..3164051 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 3164051 7143931 ECED1_3231 Escherichia coli ED1a hypothetical protein YP_002399113.1 3163785 D 585397 CDS YP_002399114.1 218690902 7143932 complement(3164035..3165333) 1 NC_011745.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 3165333 eno 7143932 eno Escherichia coli ED1a phosphopyruvate hydratase YP_002399114.1 3164035 R 585397 CDS YP_002399115.1 218690903 7139793 complement(3165421..3167058) 1 NC_011745.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 3167058 pyrG 7139793 pyrG Escherichia coli ED1a CTP synthetase YP_002399115.1 3165421 R 585397 CDS YP_002399116.1 218690904 7141236 complement(3167286..3168077) 1 NC_011745.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era; nucleoside triphosphate pyrophosphohydrolase 3168077 mazG 7141236 mazG Escherichia coli ED1a nucleoside triphosphate pyrophosphohydrolase YP_002399116.1 3167286 R 585397 CDS YP_002399117.1 218690905 7142216 complement(3168149..3168484) 1 NC_011745.1 MazF; endoribonuclease; toxin of the ChpA-ChpR toxin-antitoxin system; toxin ChpA 3168484 chpA 7142216 chpA Escherichia coli ED1a toxin ChpA YP_002399117.1 3168149 R 585397 CDS YP_002399118.1 218690906 7139345 complement(3168484..3168732) 1 NC_011745.1 part of the MazF-MazE toxin-antitoxin system; conteracts MazF; antitoxin MazE 3168732 chpR 7139345 chpR Escherichia coli ED1a antitoxin MazE YP_002399118.1 3168484 R 585397 CDS YP_002399119.1 218690907 7139346 complement(3168810..3171044) 1 NC_011745.1 (p)ppGpp synthetase; catalyzes the formation of pppGpp and ppGpp from ATP and GTP or GDP; GDP/GTP pyrophosphokinase 3171044 relA 7139346 relA Escherichia coli ED1a GDP/GTP pyrophosphokinase YP_002399119.1 3168810 R 585397 CDS YP_002399120.1 218690908 7141586 complement(3171092..3172393) 1 NC_011745.1 in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]; 23S rRNA 5-methyluridine methyltransferase 3172393 rumA 7141586 rumA Escherichia coli ED1a 23S rRNA 5-methyluridine methyltransferase YP_002399120.1 3171092 R 585397 CDS YP_002399121.1 218690909 7140135 3172450..3175206 1 NC_011745.1 part of the two-component regulatory system with UvrY; involved in the regulation of carbon metabolism via the csrA/csrB regulatory system; hybrid sensory histidine kinase BarA 3175206 barA 7140135 barA Escherichia coli ED1a hybrid sensory histidine kinase BarA YP_002399121.1 3172450 D 585397 CDS YP_002399122.1 218690910 7140429 complement(3175437..3176777) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20233700, 9772162, 10762278, 13971911; Product type e : enzyme; (D)-glucarate dehydratase 1 3176777 gudD 7140429 gudD Escherichia coli ED1a (D)-glucarate dehydratase 1 YP_002399122.1 3175437 R 585397 CDS YP_002399123.1 218690911 7139847 complement(3176798..3178138) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9772162; Product type e : enzyme; glucarate dehydratase 3178138 gudX 7139847 gudX Escherichia coli ED1a glucarate dehydratase YP_002399123.1 3176798 R 585397 CDS YP_002399124.1 218690912 7139849 complement(3178140..3179492) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10762278; Product type pt : putative transporter; putative D-glucarate transporter 3179492 gudP 7139849 gudP Escherichia coli ED1a putative D-glucarate transporter YP_002399124.1 3178140 R 585397 CDS YP_002399125.1 218690913 7139848 complement(3179926..3180375) 1 NC_011745.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin 3180375 yqcA 7139848 yqcA Escherichia coli ED1a flavodoxin YP_002399125.1 3179926 R 585397 CDS YP_002399126.1 218690914 7140309 complement(3180393..3181175) 1 NC_011745.1 catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp; tRNA pseudouridine synthase C 3181175 truC 7140309 truC Escherichia coli ED1a tRNA pseudouridine synthase C YP_002399126.1 3180393 R 585397 CDS YP_002399127.1 218690915 7140829 complement(3181175..3181504) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3181504 yqcC 7140829 yqcC Escherichia coli ED1a hypothetical protein YP_002399127.1 3181175 R 585397 CDS YP_002399128.1 218690916 7142076 complement(3182126..3182671) 1 NC_011745.1 putative SecY regulator that either chelates excess SecY or negatively regulates the SecYE translocase function; SecY interacting protein Syd 3182671 syd 7142076 syd Escherichia coli ED1a SecY interacting protein Syd YP_002399128.1 3182126 R 585397 CDS YP_002399129.1 218690917 7141502 3182739..3183587 1 NC_011745.1 catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 3183587 queF 7141502 queF Escherichia coli ED1a 7-cyano-7-deazaguanine reductase YP_002399129.1 3182739 D 585397 CDS YP_002399130.1 218690918 7141246 3183699..3185063 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3185063 ygdH 7141246 ygdH Escherichia coli ED1a hypothetical protein YP_002399130.1 3183699 D 585397 CDS YP_002399131.1 218690919 7143787 3185620..3186909 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8752353, 8026499; Product type pt : putative transporter; putative serine transporter 3186909 sdaC 7143787 sdaC Escherichia coli ED1a putative serine transporter YP_002399131.1 3185620 D 585397 CDS YP_002399132.1 218690920 7141379 3186967..3188334 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91193203, 93215657, 8385012; Product type e : enzyme; L-serine deaminase II 3188334 sdaB 7141379 sdaB Escherichia coli ED1a L-serine deaminase II YP_002399132.1 3186967 D 585397 CDS YP_002399133.1 218690921 7141378 3188356..3189201 1 NC_011745.1 has 3'-5' exonuclease activity that preferentially acts on ssDNA; also 3'-phosphodiesterase activity at sites with 3' incised apurinic/apyrimidinic sites; can remove 3' phosphoglycolate groups; exonuclease IX 3189201 xni 7141378 xni Escherichia coli ED1a exonuclease IX YP_002399133.1 3188356 D 585397 CDS YP_002399134.1 218690922 7139832 complement(3189306..3190457) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88142551, 89291720, 2553671, 2661535, 2664711, 8385012; Product type e : enzyme; L-1,2-propanediol oxidoreductase 3190457 fucO 7139832 fucO Escherichia coli ED1a L-1,2-propanediol oxidoreductase YP_002399134.1 3189306 R 585397 CDS YP_002399135.1 218690923 7143127 complement(3190482..3191129) 1 NC_011745.1 catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase 3191129 fucA 7143127 fucA Escherichia coli ED1a L-fuculose phosphate aldolase YP_002399135.1 3190482 R 585397 CDS YP_002399136.1 218690924 7143124 3191676..3192992 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88142551, 90036697, 2553671, 2664711, 7783647; Product type t : transporter; L-fucose transporter 3192992 fucP 7143124 fucP Escherichia coli ED1a L-fucose transporter YP_002399136.1 3191676 D 585397 CDS YP_002399137.1 218690925 7143128 3193025..3194800 1 NC_011745.1 catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose; L-fucose isomerase 3194800 fucI 7143128 fucI Escherichia coli ED1a L-fucose isomerase YP_002399137.1 3193025 D 585397 CDS YP_002399138.1 218690926 7143125 3194879..3196327 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88142551, 90036697, 2664711, 13905785; Product type e : enzyme; L-fuculokinase 3196327 fucK 7143125 fucK Escherichia coli ED1a L-fuculokinase YP_002399138.1 3194879 D 585397 CDS YP_002399139.1 218690927 7143126 3196329..3196751 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15060078, 12738765, 80049526, 2664711; Product type e : enzyme; L-fucose mutarotase 3196751 fucU 7143126 fucU Escherichia coli ED1a L-fucose mutarotase YP_002399139.1 3196329 D 585397 CDS YP_002399140.1 218690928 7143130 3196809..3197540 1 NC_011745.1 regulates expression of genes involved in L-fucose utilization; DNA-binding transcriptional activator FucR 3197540 fucR 7143130 fucR Escherichia coli ED1a DNA-binding transcriptional activator FucR YP_002399140.1 3196809 D 585397 CDS YP_002399141.1 218690929 7143129 complement(3197584..3198684) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 21188420, 7704273; Product type pe : putative enzyme; putative RNA 2'-O-ribose methyltransferase 3198684 ygdE 7143129 ygdE Escherichia coli ED1a putative RNA 2'-O-ribose methyltransferase YP_002399141.1 3197584 R 585397 CDS YP_002399142.1 218690930 7143786 complement(3198677..3199072) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7704273; Product type pm : putative membrane component; hypothetical protein 3199072 ygdD 7143786 ygdD Escherichia coli ED1a hypothetical protein YP_002399142.1 3198677 R 585397 CDS YP_002399143.1 218690931 7143785 complement(3199091..3200008) 1 NC_011745.1 Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence; DNA-binding transcriptional activator GcvA 3200008 gcvA 7143785 gcvA Escherichia coli ED1a DNA-binding transcriptional activator GcvA YP_002399143.1 3199091 R 585397 CDS YP_002399144.1 218690932 7143168 3200326..3200619 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 3200619 7143168 ECED1_3262 Escherichia coli ED1a hypothetical protein YP_002399144.1 3200326 D 585397 CDS YP_002399145.1 218690933 7143933 complement(3200359..3200586) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3200586 ygdI 7143933 ygdI Escherichia coli ED1a hypothetical protein YP_002399145.1 3200359 R 585397 CDS YP_002399146.1 218690934 7143788 3200778..3201983 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15148362, 9278392, 10739946, 10829016; Product type e : enzyme; cysteine sulfinate desulfinase 3201983 csdA 7143788 csdA Escherichia coli ED1a cysteine sulfinate desulfinase YP_002399146.1 3200778 D 585397 CDS YP_002399147.1 218690935 7142059 3201983..3202426 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative Fe-S metabolism protein (sufE-like) 3202426 ygdK 7142059 ygdK Escherichia coli ED1a putative Fe-S metabolism protein (sufE-like) YP_002399147.1 3201983 D 585397 CDS YP_002399148.1 218690936 7143789 complement(3202477..3203283) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3203283 ygdL 7143789 ygdL Escherichia coli ED1a hypothetical protein YP_002399148.1 3202477 R 585397 CDS YP_002399149.1 218690937 7143790 complement(3203360..3204457) 1 NC_011745.1 membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase A 3204457 mltA 7143790 mltA Escherichia coli ED1a murein transglycosylase A YP_002399149.1 3203360 R 585397 CDS YP_002399150.1 218690938 7140576 complement(3205042..3205998) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; 2-hydroxyacid dehydrogenase 3205998 7140576 ECED1_3268 Escherichia coli ED1a 2-hydroxyacid dehydrogenase YP_002399150.1 3205042 R 585397 CDS YP_002399151.1 218690939 7143934 complement(3206061..3206657) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphosugar isomerase 3206657 7143934 ECED1_3269 Escherichia coli ED1a putative phosphosugar isomerase YP_002399151.1 3206061 R 585397 CDS YP_002399152.1 218690940 7143935 complement(3206660..3207835) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative aminotransferase 3207835 7143935 ECED1_3270 Escherichia coli ED1a putative aminotransferase YP_002399152.1 3206660 R 585397 CDS YP_002399153.1 218690941 7143936 complement(3207835..3209415) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; PTS system maltose and glucose-specific transporter subunit IIABC 3209415 7143936 ECED1_3271 Escherichia coli ED1a PTS system maltose and glucose-specific transporter subunit IIABC YP_002399153.1 3207835 R 585397 CDS YP_002399154.1 218690942 7143937 complement(3209447..3210328) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcription antiterminator 3210328 7143937 ECED1_3272 Escherichia coli ED1a putative transcription antiterminator YP_002399154.1 3209447 R 585397 CDS YP_002399155.1 218690943 7143938 complement(3210529..3211782) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12787347, 21348478; Product type e : enzyme; N-acetylmuramoyl-L-alanine amidase 3211782 amiC 7143938 amiC Escherichia coli ED1a N-acetylmuramoyl-L-alanine amidase YP_002399155.1 3210529 R 585397 CDS YP_002399156.1 218690944 7143704 3212014..3213345 1 NC_011745.1 catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; N-acetylglutamate synthase 3213345 argA 7143704 argA Escherichia coli ED1a N-acetylglutamate synthase YP_002399156.1 3212014 D 585397 CDS YP_002399157.1 218690945 7142609 complement(3213407..3215233) 1 NC_011745.1 helicase/nuclease; with RecBC catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit alpha 3215233 recD 7142609 recD Escherichia coli ED1a exonuclease V subunit alpha YP_002399157.1 3213407 R 585397 CDS YP_002399158.1 218690946 7141577 complement(3215233..3218775) 1 NC_011745.1 helicase/nuclease; with RecCD catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit beta 3218775 recB 7141577 recB Escherichia coli ED1a exonuclease V subunit beta YP_002399158.1 3215233 R 585397 CDS YP_002399159.1 218690947 7141575 complement(3218768..3221656) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91193232, 1570301, 3308636, 3534791, 3537960, 8099278; Product type e : enzyme; protease III 3221656 ptr 7141575 ptr Escherichia coli ED1a protease III YP_002399159.1 3218768 R 585397 CDS YP_002399160.1 218690948 7141203 complement(3221832..3225200) 1 NC_011745.1 catalyzes ATP-dependent exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides; component of the RecBCD (Exo V) helicase/nuclease complex that is essential for recombination; exonuclease V subunit gamma 3225200 recC 7141203 recC Escherichia coli ED1a exonuclease V subunit gamma YP_002399160.1 3221832 R 585397 CDS YP_002399161.1 218690949 7141576 complement(3225213..3225536) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 7934814; Product type e : enzyme; hypothetical protein 3225536 ppdC 7141576 ppdC Escherichia coli ED1a hypothetical protein YP_002399161.1 3225213 R 585397 CDS YP_002399162.1 218690950 7139099 complement(3225521..3225928) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3225928 ygdB 7139099 ygdB Escherichia coli ED1a hypothetical protein YP_002399162.1 3225521 R 585397 CDS YP_002399163.1 218690951 7143784 complement(3225925..3226488) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 7934814; Product type e : enzyme; hypothetical protein 3226488 ppdB 7143784 ppdB Escherichia coli ED1a hypothetical protein YP_002399163.1 3225925 R 585397 CDS YP_002399164.1 218690952 7139098 complement(3226479..3226949) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 7934814; Product type e : enzyme; hypothetical protein 3226949 ppdA 7139098 ppdA Escherichia coli ED1a hypothetical protein YP_002399164.1 3226479 R 585397 CDS YP_002399165.1 218690953 7139097 complement(3227134..3227928) 1 NC_011745.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 3227928 thyA 7139097 thyA Escherichia coli ED1a thymidylate synthase YP_002399165.1 3227134 R 585397 CDS YP_002399166.1 218690954 7141555 complement(3227935..3228810) 1 NC_011745.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 3228810 lgt 7141555 lgt Escherichia coli ED1a prolipoprotein diacylglyceryl transferase YP_002399166.1 3227935 R 585397 CDS YP_002399167.1 218690955 7141884 complement(3228961..3231207) 1 NC_011745.1 member of a second PTS chain involved in nitrogen metabolism; PtsP phosphorylates NPr; fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain 3231207 ptsP 7141884 ptsP Escherichia coli ED1a fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain YP_002399167.1 3228961 R 585397 CDS YP_002399168.1 218690956 7141212 complement(3231220..3231750) 1 NC_011745.1 hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase 3231750 nudH 7141212 nudH Escherichia coli ED1a dinucleoside polyphosphate hydrolase YP_002399168.1 3231220 R 585397 CDS YP_002399169.1 218690957 7139943 3232435..3233124 1 NC_011745.1 MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair; DNA mismatch repair protein 3233124 mutH 7139943 mutH Escherichia coli ED1a DNA mismatch repair protein YP_002399169.1 3232435 D 585397 CDS YP_002399170.1 218690958 7139054 3233193..3233906 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3233906 ygdQ 7139054 ygdQ Escherichia coli ED1a hypothetical protein YP_002399170.1 3233193 D 585397 CDS YP_002399171.1 218690959 7139465 3234044..3234262 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3234262 ygdR 7139465 ygdR Escherichia coli ED1a hypothetical protein YP_002399171.1 3234044 D 585397 CDS YP_002399172.1 218690960 7139594 3234370..3235410 1 NC_011745.1 complements the prephenate dehydrogenase dysfunction of an Escherichia coli tyrosine auxotroph strain; member of the aldo/keto reductase 2 family; crystal structure of purified Escherichia coli protein shows bound NADPH; putative aldo-keto reductase 3235410 tas 7139594 tas Escherichia coli ED1a putative aldo-keto reductase YP_002399172.1 3234370 D 585397 CDS YP_002399173.1 218690961 7141511 complement(3235442..3236635) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8300626; Product type pm : putative membrane component; lysophospholipid transporter LplT 3236635 ygeD 7141511 ygeD Escherichia coli ED1a lysophospholipid transporter LplT YP_002399173.1 3235442 R 585397 CDS YP_002399174.1 218690962 7139596 complement(3236628..3238787) 1 NC_011745.1 Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase 3238787 aas 7139596 aas Escherichia coli ED1a bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase YP_002399174.1 3236628 R 585397 CDS YP_002399175.1 218690963 7139979 3239373..3240404 1 NC_011745.1 controls transcription of galETKM; DNA-binding transcriptional regulator GalR 3240404 galR 7139979 galR Escherichia coli ED1a DNA-binding transcriptional regulator GalR YP_002399175.1 3239373 D 585397 CDS YP_002399176.1 218690964 7143153 complement(3240411..3241673) 1 NC_011745.1 catalyzes the decarboxylation of diaminopimelate into lysine; pyridoxal phosphate(PLP)-binding; diaminopimelate decarboxylase 3241673 lysA 7143153 lysA Escherichia coli ED1a diaminopimelate decarboxylase YP_002399176.1 3240411 R 585397 CDS YP_002399177.1 218690965 7141931 3241795..3242730 1 NC_011745.1 activates the transcription of the lysA gene encoding diaminopimelate decarboxylase; DNA-binding transcriptional regulator LysR 3242730 lysR 7141931 lysR Escherichia coli ED1a DNA-binding transcriptional regulator LysR YP_002399177.1 3241795 D 585397 CDS YP_002399178.1 218690966 7141934 complement(3242717..3243409) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15135544; Product type pe : putative enzyme; putative racemase 3243409 ygeA 7141934 ygeA Escherichia coli ED1a putative racemase YP_002399178.1 3242717 R 585397 CDS YP_002399179.1 218690967 7139595 complement(3243538..3244956) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7030324, 90239116, 91154204, 2836407, 3543693, 6319708; Product type t : transporter; arabinose transporter 3244956 araE 7139595 araE Escherichia coli ED1a arabinose transporter YP_002399179.1 3243538 R 585397 CDS YP_002399180.1 218690968 7142600 complement(3245294..3246055) 1 NC_011745.1 catalyzes the formation of 3-dehydro-2-deoxy-D-gluconate from 2-deoxy-D-gluconate; 2-deoxy-D-gluconate 3-dehydrogenase 3246055 kduD 7142600 kduD Escherichia coli ED1a 2-deoxy-D-gluconate 3-dehydrogenase YP_002399180.1 3245294 R 585397 CDS YP_002399181.1 218690969 7142503 complement(3246085..3246921) 1 NC_011745.1 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate; 5-keto-4-deoxyuronate isomerase 3246921 kduI 7142503 kduI Escherichia coli ED1a 5-keto-4-deoxyuronate isomerase YP_002399181.1 3246085 R 585397 CDS YP_002399182.1 218690970 7142504 complement(3247208..3248389) 1 NC_011745.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis; acetyl-CoA acetyltransferase 3248389 yqeF 7142504 yqeF Escherichia coli ED1a acetyl-CoA acetyltransferase YP_002399182.1 3247208 R 585397 CDS YP_002399183.1 218690971 7140315 3248644..3249804 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 3249804 yqeG 7140315 yqeG Escherichia coli ED1a putative transporter YP_002399183.1 3248644 D 585397 CDS YP_002399184.1 218690972 7140316 complement(3250881..3251273) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Antitermination protein Q from prophage 3251273 Q 7140316 Q Escherichia coli ED1a Antitermination protein Q from prophage YP_002399184.1 3250881 R 585397 CDS YP_002399185.1 218690973 7141240 complement(3251464..3251631) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3251631 7141240 ECED1_3304 Escherichia coli ED1a hypothetical protein YP_002399185.1 3251464 R 585397 CDS YP_002399186.1 218690974 7143939 complement(3251789..3252256) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3252256 7143939 ECED1_3305 Escherichia coli ED1a hypothetical protein YP_002399186.1 3251789 R 585397 CDS YP_002399187.1 218690975 7143940 complement(3252837..3253940) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase; KpLE2 phage-like element 3253940 yjhC 7143940 yjhC Escherichia coli ED1a putative oxidoreductase; KpLE2 phage-like element YP_002399187.1 3252837 R 585397 CDS YP_002399188.1 218690976 7139575 complement(3253953..3255170) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sialic acid transporter 3255170 yjhB 7139575 yjhB Escherichia coli ED1a putative sialic acid transporter YP_002399188.1 3253953 R 585397 CDS YP_002399189.1 218690977 7139574 complement(3255918..3256358) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative single-stranded DNA-binding protein (SSB) (Helix-destabilizing protein) 3256358 7139574 ECED1_3309 Escherichia coli ED1a putative single-stranded DNA-binding protein (SSB) (Helix-destabilizing protein) YP_002399189.1 3255918 R 585397 CDS YP_002399190.1 218690978 7143941 complement(3256355..3256804) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3256804 7143941 ECED1_3310 Escherichia coli ED1a hypothetical protein YP_002399190.1 3256355 R 585397 CDS YP_002399191.1 218690979 7143942 complement(3257092..3258912) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative DNA primase from prophage 3258912 7143942 ECED1_3311 Escherichia coli ED1a putative DNA primase from prophage YP_002399191.1 3257092 R 585397 CDS YP_002399192.1 218690980 7143943 complement(3258909..3259202) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3259202 7143943 ECED1_3312 Escherichia coli ED1a hypothetical protein YP_002399192.1 3258909 R 585397 CDS YP_002399193.1 218690981 7143944 complement(3259260..3259463) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3259463 7143944 ECED1_3313 Escherichia coli ED1a hypothetical protein YP_002399193.1 3259260 R 585397 CDS YP_002399194.1 218690982 7143945 complement(3259641..3260939) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3260939 7143945 ECED1_3314 Escherichia coli ED1a hypothetical protein YP_002399194.1 3259641 R 585397 CDS YP_002399195.1 218690983 7143946 3260557..3260835 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3260835 7143946 ECED1_3316 Escherichia coli ED1a hypothetical protein YP_002399195.1 3260557 D 585397 CDS YP_002399196.1 218690984 7143947 complement(3260936..3261154) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3261154 7143947 ECED1_3317 Escherichia coli ED1a hypothetical protein YP_002399196.1 3260936 R 585397 CDS YP_002399197.1 218690985 7143948 complement(3261141..3261878) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3261878 7143948 ECED1_3318 Escherichia coli ED1a hypothetical protein YP_002399197.1 3261141 R 585397 CDS YP_002399198.1 218690986 7143949 complement(3261871..3262386) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3262386 7143949 ECED1_3319 Escherichia coli ED1a hypothetical protein YP_002399198.1 3261871 R 585397 CDS YP_002399199.1 218690987 7143950 complement(3262451..3262654) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative regulatory protein from prophage (AlpA family) 3262654 7143950 ECED1_3320 Escherichia coli ED1a putative regulatory protein from prophage (AlpA family) YP_002399199.1 3262451 R 585397 CDS YP_002399200.1 218690988 7143951 3262917..3263084 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 3263084 7143951 ECED1_3322 Escherichia coli ED1a hypothetical protein YP_002399200.1 3262917 D 585397 CDS YP_002399201.1 218690989 7143952 3263062..3263235 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 3263235 7143952 ECED1_3323 Escherichia coli ED1a hypothetical protein YP_002399201.1 3263062 D 585397 CDS YP_002399202.1 218690990 7142872 complement(3263297..3264550) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Integrase from prophage 3264550 int 7142872 int Escherichia coli ED1a Integrase from prophage YP_002399202.1 3263297 R 585397 CDS YP_002399203.1 218690991 7140612 complement(3264828..3265583) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15150243; Product type r : regulator; Tetratricopeptide repeat transcriptional regulator 3265583 ygeR 7140612 ygeR Escherichia coli ED1a Tetratricopeptide repeat transcriptional regulator YP_002399203.1 3264828 R 585397 CDS YP_002399204.1 218690992 7139597 3266036..3268294 1 NC_011745.1 putative molybdenum cofactor-binding protein; participates in purine salvage; xanthine dehydrogenase subunit XdhA 3268294 xdhA 7139597 xdhA Escherichia coli ED1a xanthine dehydrogenase subunit XdhA YP_002399204.1 3266036 D 585397 CDS YP_002399205.1 218690993 7139202 3268305..3269183 1 NC_011745.1 FAD-binding subunit; with XdhA and XdhC participates in purine salvage; xanthine dehydrogenase subunit XdhB 3269183 xdhB 7139202 xdhB Escherichia coli ED1a xanthine dehydrogenase subunit XdhB YP_002399205.1 3268305 D 585397 CDS YP_002399206.1 218690994 7139203 3269180..3269659 1 NC_011745.1 iron-sulfur-binding subunit; with XdhA and XdhB participates in purine salvage; xanthine dehydrogenase subunit XdhC 3269659 xdhC 7139203 xdhC Escherichia coli ED1a xanthine dehydrogenase subunit XdhC YP_002399206.1 3269180 D 585397 CDS YP_002399207.1 218690995 7139204 complement(3269699..3271477) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3271477 ygeV 7139204 ygeV Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002399207.1 3269699 R 585397 CDS YP_002399208.1 218690996 7139598 3271953..3273143 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; aspartate/ornithine carbamoyltransferase family protein 3273143 ygeW 7139598 ygeW Escherichia coli ED1a aspartate/ornithine carbamoyltransferase family protein YP_002399208.1 3271953 D 585397 CDS YP_002399209.1 218690997 7139599 3273201..3274397 1 NC_011745.1 catalyzes the formation of pyruvate from 2,3-diaminopropionate; diaminopropionate ammonia-lyase 3274397 ygeX 7139599 ygeX Escherichia coli ED1a diaminopropionate ammonia-lyase YP_002399209.1 3273201 D 585397 CDS YP_002399210.1 218690998 7139600 3274455..3275666 1 NC_011745.1 Zn-dependent extracellular dipeptidase; similar to succinyl-diaminopimelate desuccinylases; peptidase 3275666 ygeY 7139600 ygeY Escherichia coli ED1a peptidase YP_002399210.1 3274455 D 585397 CDS YP_002399211.1 218690999 7139601 3275720..3277105 1 NC_011745.1 catalyzes the hydrolytic cleavage of hydantoin with aromatic side chains at the 5'position; phenylhydantoinase 3277105 hyuA 7139601 hyuA Escherichia coli ED1a phenylhydantoinase YP_002399211.1 3275720 D 585397 CDS YP_002399212.1 218691000 7140210 3277153..3278085 1 NC_011745.1 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 3278085 yqeA 7140210 yqeA Escherichia coli ED1a carbamate kinase YP_002399212.1 3277153 D 585397 CDS YP_002399213.1 218691001 7140312 complement(3278126..3279751) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3279751 yqeB 7140312 yqeB Escherichia coli ED1a hypothetical protein YP_002399213.1 3278126 R 585397 CDS YP_002399214.1 218691002 7140313 complement(3279799..3280569) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3280569 yqeC 7140313 yqeC Escherichia coli ED1a hypothetical protein YP_002399214.1 3279799 R 585397 CDS YP_002399215.1 218691003 7140314 3280673..3281251 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3281251 ygfJ 7140314 ygfJ Escherichia coli ED1a hypothetical protein YP_002399215.1 3280673 D 585397 CDS YP_002399216.1 218691004 7139605 3281573..3284671 1 NC_011745.1 with YgfM and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfK mutants are unable to reduce selenate; involved in purine salvage process; seems to act as an oxidoreductase, but sequence similarity suggests it is a dihydrothymine dehydrogenase; putative selenate reductase subunit YgfK 3284671 ygfK 7139605 ygfK Escherichia coli ED1a putative selenate reductase subunit YgfK YP_002399216.1 3281573 D 585397 CDS YP_002399217.1 218691005 7139606 3284674..3286002 1 NC_011745.1 in Escherichia coli expression is induced in response to phase-specific signals and controlled by RpoS; putative chlorohydrolase/aminohydrolase 3286002 ssnA 7139606 ssnA Escherichia coli ED1a putative chlorohydrolase/aminohydrolase YP_002399217.1 3284674 D 585397 CDS YP_002399218.1 218691006 7143850 3286053..3286832 1 NC_011745.1 with YgfK and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfM contains a FAD domain; putative selenate reductase subunit YgfM 3286832 ygfM 7143850 ygfM Escherichia coli ED1a putative selenate reductase subunit YgfM YP_002399218.1 3286053 D 585397 CDS YP_002399219.1 218691007 7139607 3286829..3289699 1 NC_011745.1 with YgfK and YgfM forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; molybdopterin-containing enzyme; oxidase activity toward hypoxanthine and xanthine can be detected if these substrates are present at high concentration; putative selenate reductase subunit YgfN 3289699 xdhD 7139607 xdhD Escherichia coli ED1a putative selenate reductase subunit YgfN YP_002399219.1 3286829 D 585397 CDS YP_002399220.1 218691008 7139205 3289864..3291264 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20372655, 98213740; Product type pt : putative transporter; putative transporter 3291264 ygfO 7139205 ygfO Escherichia coli ED1a putative transporter YP_002399220.1 3289864 D 585397 CDS YP_002399221.1 218691009 7139608 3291279..3292598 1 NC_011745.1 Catalyzes the deamination of guanine; guanine deaminase 3292598 guaD 7139608 guaD Escherichia coli ED1a guanine deaminase YP_002399221.1 3291279 D 585397 CDS YP_002399222.1 218691010 7139846 3292634..3294001 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 3294001 ygfQ 7139846 ygfQ Escherichia coli ED1a putative transporter YP_002399222.1 3292634 D 585397 CDS YP_002399223.1 218691011 7139609 complement(3294037..3294525) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative oxidoreductase, 4Fe-4S ferredoxin-type subunit 3294525 ygfS 7139609 ygfS Escherichia coli ED1a putative oxidoreductase, 4Fe-4S ferredoxin-type subunit YP_002399223.1 3294037 R 585397 CDS YP_002399224.1 218691012 7139610 complement(3294525..3296444) 1 NC_011745.1 unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic); putative oxidoreductase Fe-S binding subunit 3296444 ygfT 7139610 ygfT Escherichia coli ED1a putative oxidoreductase Fe-S binding subunit YP_002399224.1 3294525 R 585397 CDS YP_002399225.1 218691013 7139611 3296880..3298328 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9098051; Product type t : transporter; transporter 3298328 ygfU 7139611 ygfU Escherichia coli ED1a transporter YP_002399225.1 3296880 D 585397 CDS YP_002399226.1 218691014 7139612 3298578..3299126 1 NC_011745.1 catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate; isopentenyl-diphosphate delta-isomerase 3299126 idi 7139612 idi Escherichia coli ED1a isopentenyl-diphosphate delta-isomerase YP_002399226.1 3298578 D 585397 CDS YP_002399227.1 218691015 7140224 complement(3299169..3300686) 1 NC_011745.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 3300686 lysS 7140224 lysS Escherichia coli ED1a lysyl-tRNA synthetase YP_002399227.1 3299169 R 585397 CDS YP_002399228.1 218691016 7141935 complement(join(3300696..3301718,3301720..3301794)) 1 NC_011745.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 3301794 prfB 7141935 prfB Escherichia coli ED1a peptide chain release factor 2 YP_002399228.1 3300696 R 585397 CDS YP_002399229.1 218691017 7139116 complement(3301885..3303618) 1 NC_011745.1 5'-3' single-stranded-DNA-specific exonuclease; ssDNA exonuclease RecJ 3303618 recJ 7139116 recJ Escherichia coli ED1a ssDNA exonuclease RecJ YP_002399229.1 3301885 R 585397 CDS YP_002399230.1 218691018 7141580 complement(3303624..3304334) 1 NC_011745.1 DsbC; periplasmic protein with protein disulfide isomerase activity; this protein also shows disulfide oxidoreductase activity; thiol:disulfide interchange protein DsbC 3304334 dsbC 7141580 dsbC Escherichia coli ED1a thiol:disulfide interchange protein DsbC YP_002399230.1 3303624 R 585397 CDS YP_002399231.1 218691019 7140523 complement(3304359..3305255) 1 NC_011745.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD 3305255 xerD 7140523 xerD Escherichia coli ED1a site-specific tyrosine recombinase XerD YP_002399231.1 3304359 R 585397 CDS YP_002399232.1 218691020 7139207 3305367..3305888 1 NC_011745.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic; flavodoxin FldB 3305888 fldB 7139207 fldB Escherichia coli ED1a flavodoxin FldB YP_002399232.1 3305367 D 585397 CDS YP_002399233.1 218691021 7144197 complement(3305928..3306335) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3306335 ygfX 7144197 ygfX Escherichia coli ED1a hypothetical protein YP_002399233.1 3305928 R 585397 CDS YP_002399234.1 218691022 7139613 complement(3306316..3306582) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3306582 ygfY 7139613 ygfY Escherichia coli ED1a hypothetical protein YP_002399234.1 3306316 R 585397 CDS YP_002399235.1 218691023 7139614 3306825..3307805 1 NC_011745.1 physiological role is not clear; not essential for growth but mutants grow poorly; mutations suppress hda null mutations; may be involved in regulation of ATP-DnaA levels; may also be involved in regulation of tRNA modifications; can bind folic acid and tetrahydrofolate; forms a three domain ring-like structure with a central channel; structurally similar to DMGO protein from A. globiformis; shows sequence similarity to yeast CAF17 transcriptional regulator; putative global regulator 3307805 ygfZ 7139614 ygfZ Escherichia coli ED1a putative global regulator YP_002399235.1 3306825 D 585397 CDS YP_002399236.1 218691024 7139615 complement(3307882..3308541) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative hemolysin, inner membrane subunit 3308541 yqfA 7139615 yqfA Escherichia coli ED1a putative hemolysin, inner membrane subunit YP_002399236.1 3307882 R 585397 CDS YP_002399237.1 218691025 7140317 complement(3308705..3309016) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3309016 yqfB 7140317 yqfB Escherichia coli ED1a hypothetical protein YP_002399237.1 3308705 R 585397 CDS YP_002399238.1 218691026 7140318 3309055..3310494 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87222180, 88297127, 92334140; Product type e : enzyme; 6-phospho-beta-glucosidase A 3310494 bglA 7140318 bglA Escherichia coli ED1a 6-phospho-beta-glucosidase A YP_002399238.1 3309055 D 585397 CDS YP_002399239.1 218691027 7140443 complement(3310660..3313533) 1 NC_011745.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase 3313533 gcvP 7140443 gcvP Escherichia coli ED1a glycine dehydrogenase YP_002399239.1 3310660 R 585397 CDS YP_002399240.1 218691028 7143170 complement(3313651..3314040) 1 NC_011745.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor; glycine cleavage system protein H 3314040 gcvH 7143170 gcvH Escherichia coli ED1a glycine cleavage system protein H YP_002399240.1 3313651 R 585397 CDS YP_002399241.1 218691029 7143169 complement(3314064..3315158) 1 NC_011745.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T 3315158 gcvT 7143169 gcvT Escherichia coli ED1a glycine cleavage system aminomethyltransferase T YP_002399241.1 3314064 R 585397 CDS YP_002399242.1 218691030 7143172 complement(3315606..3316808) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1339425; Product type pe : putative enzyme; hypothetical protein 3316808 visC 7143172 visC Escherichia coli ED1a hypothetical protein YP_002399242.1 3315606 R 585397 CDS YP_002399243.1 218691031 7139167 complement(3316831..3318009) 1 NC_011745.1 Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone; 2-octaprenyl-6-methoxyphenyl hydroxylase 3318009 ubiH 7139167 ubiH Escherichia coli ED1a 2-octaprenyl-6-methoxyphenyl hydroxylase YP_002399243.1 3316831 R 585397 CDS YP_002399244.1 218691032 7140863 complement(3318006..3319331) 1 NC_011745.1 exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue; substrate can be as short as a dipeptide; proline aminopeptidase P II 3319331 pepP 7140863 pepP Escherichia coli ED1a proline aminopeptidase P II YP_002399244.1 3318006 R 585397 CDS YP_002399245.1 218691033 7144063 complement(3319357..3319935) 1 NC_011745.1 the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown; hypothetical protein 3319935 ygfB 7144063 ygfB Escherichia coli ED1a hypothetical protein YP_002399245.1 3319357 R 585397 CDS YP_002399246.1 218691034 7139603 3320103..3320432 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 412171; Product type cp : cell process; Z-ring-associated protein 3320432 zapA 7139603 zapA Escherichia coli ED1a Z-ring-associated protein YP_002399246.1 3320103 D 585397 CDS YP_002399247.1 218691035 7143854 3320732..3321280 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14727089, 2579060; Product type pe : putative enzyme; putative ligase 3321280 ygfA 7143854 ygfA Escherichia coli ED1a putative ligase YP_002399247.1 3320732 D 585397 CDS YP_002399248.1 218691036 7141349 complement(3321669..3322901) 1 NC_011745.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase 3322901 serA 7141349 serA Escherichia coli ED1a D-3-phosphoglycerate dehydrogenase YP_002399248.1 3321669 R 585397 CDS YP_002399249.1 218691037 7141397 complement(3323157..3323816) 1 NC_011745.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 3323816 rpiA 7141397 rpiA Escherichia coli ED1a ribose-5-phosphate isomerase A YP_002399249.1 3323157 R 585397 CDS YP_002399250.1 218691038 7141449 complement(3323872..3324102) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3324102 yqfE 7141449 yqfE Escherichia coli ED1a hypothetical protein YP_002399250.1 3323872 R 585397 CDS YP_002399251.1 218691039 7140319 3324243..3325136 1 NC_011745.1 specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport; chromosome replication initiation inhibitor protein 3325136 argP 7140319 argP Escherichia coli ED1a chromosome replication initiation inhibitor protein YP_002399251.1 3324243 D 585397 CDS YP_002399252.1 218691040 7140971 complement(3326430..3327326) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3327326 ygfI 7140971 ygfI Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002399252.1 3326430 R 585397 CDS YP_002399253.1 218691041 7139604 complement(3327484..3328224) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3328224 yggE 7139604 yggE Escherichia coli ED1a hypothetical protein YP_002399253.1 3327484 R 585397 CDS YP_002399254.1 218691042 7139618 complement(3328317..3328952) 1 NC_011745.1 Involved in the export of arginine; arginine exporter protein 3328952 argO 7139618 argO Escherichia coli ED1a arginine exporter protein YP_002399254.1 3328317 R 585397 CDS YP_002399255.1 218691043 7142617 complement(3329091..3329951) 1 NC_011745.1 participates in the regulation of osmotic pressure changes within the cel; mechanosensitive channel MscS 3329951 mscS 7142617 mscS Escherichia coli ED1a mechanosensitive channel MscS YP_002399255.1 3329091 R 585397 CDS YP_002399256.1 218691044 7139033 complement(3330142..3331221) 1 NC_011745.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 3331221 fbaA 7139033 fbaA Escherichia coli ED1a fructose-bisphosphate aldolase YP_002399256.1 3330142 R 585397 CDS YP_002399257.1 218691045 7144131 complement(3331436..3332599) 1 NC_011745.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 3332599 pgk 7144131 pgk Escherichia coli ED1a phosphoglycerate kinase YP_002399257.1 3331436 R 585397 CDS YP_002399258.1 218691046 7144075 complement(3332649..3333668) 1 NC_011745.1 NAD-dependent; catalyzes the formation of 4-phosphoerythronate from erythrose 4-phosphate in the biosynthesis of pyridoxine 5'-phosphate; erythrose 4-phosphate dehydrogenase 3333668 epd 7144075 epd Escherichia coli ED1a erythrose 4-phosphate dehydrogenase YP_002399258.1 3332649 R 585397 CDS YP_002399259.1 218691047 7139803 3334040..3334471 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3334471 7139803 ECED1_3384 Escherichia coli ED1a hypothetical protein YP_002399259.1 3334040 D 585397 CDS YP_002399260.1 218691048 7141266 3334494..3335072 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC-type transport system 3335072 7141266 ECED1_3385 Escherichia coli ED1a putative ABC-type transport system YP_002399260.1 3334494 D 585397 CDS YP_002399261.1 218691049 7141267 3335073..3335780 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC-type transport system 3335780 7141267 ECED1_3386 Escherichia coli ED1a putative ABC-type transport system YP_002399261.1 3335073 D 585397 CDS YP_002399262.1 218691050 7141268 3335762..3336445 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ATP-binding protein of ABC transport system 3336445 7141268 ECED1_3387 Escherichia coli ED1a putative ATP-binding protein of ABC transport system YP_002399262.1 3335762 D 585397 CDS YP_002399263.1 218691051 7141269 3336406..3337116 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ATP-binding protein of ABC transport system 3337116 7141269 ECED1_3388 Escherichia coli ED1a putative ATP-binding protein of ABC transport system YP_002399263.1 3336406 D 585397 CDS YP_002399264.1 218691052 7141270 complement(3337088..3337801) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative fructose transport system kinase 3337801 frcK 7141270 frcK Escherichia coli ED1a putative fructose transport system kinase YP_002399264.1 3337088 R 585397 CDS YP_002399265.1 218691053 7139616 complement(3337798..3338307) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3338307 yggD 7139616 yggD Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002399265.1 3337798 R 585397 CDS YP_002399266.1 218691054 7139620 complement(3338641..3339918) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative dehydrogenase 3339918 yggP 7139620 yggP Escherichia coli ED1a putative dehydrogenase YP_002399266.1 3338641 R 585397 CDS YP_002399267.1 218691055 7139627 complement(3339933..3341321) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8353127; Product type t : transporter; fused mannitol-specific PTS enzymes: IIB component ; IIC component 3341321 cmtA 7139627 cmtA Escherichia coli ED1a fused mannitol-specific PTS enzymes: IIB component ; IIC component YP_002399267.1 3339933 R 585397 CDS YP_002399268.1 218691056 7139382 complement(3341349..3341792) 1 NC_011745.1 TolM; with CmtA (IIBC), CmtB possibly forms the mannitol-like permease component of the cryptic mannitol phosphotransferase system, which phosphorylates and transports various carbohydrates and polyhydric alcohols in Escherichia coli; cytoplasmic protein; putative mannitol phosphotransferase subunit EIIA 3341792 cmtB 7139382 cmtB Escherichia coli ED1a putative mannitol phosphotransferase subunit EIIA YP_002399268.1 3341349 R 585397 CDS YP_002399269.1 218691057 7139383 3342109..3343077 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane protease 3343077 7139383 ECED1_3396 Escherichia coli ED1a putative membrane protease YP_002399269.1 3342109 D 585397 CDS YP_002399270.1 218691058 7141271 complement(3343296..3345287) 1 NC_011745.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 3345287 tktA 7141271 tktA Escherichia coli ED1a transketolase YP_002399270.1 3343296 R 585397 CDS YP_002399271.1 218691059 7141559 3345565..3346323 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1310091; Product type pe : putative enzyme; putative peptidase 3346323 yggG 7141559 yggG Escherichia coli ED1a putative peptidase YP_002399271.1 3345565 D 585397 CDS YP_002399272.1 218691060 7139621 complement(3346527..3347447) 1 NC_011745.1 catalyzes the formation of putrescine from agmatine; agmatinase 3347447 speB 7139621 speB Escherichia coli ED1a agmatinase YP_002399272.1 3346527 R 585397 CDS YP_002399273.1 218691061 7143824 complement(3347583..3348314) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3348314 7143824 ECED1_3400 Escherichia coli ED1a hypothetical protein YP_002399273.1 3347583 R 585397 CDS YP_002399274.1 218691062 7141272 complement(3348460..3350436) 1 NC_011745.1 catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis; arginine decarboxylase 3350436 speA 7141272 speA Escherichia coli ED1a arginine decarboxylase YP_002399274.1 3348460 R 585397 CDS YP_002399275.1 218691063 7143823 complement(3350445..3350591) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3350591 yqgB 7143823 yqgB Escherichia coli ED1a hypothetical protein YP_002399275.1 3350445 R 585397 CDS YP_002399276.1 218691064 7140321 3350712..3350927 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3350927 yqgC 7140321 yqgC Escherichia coli ED1a hypothetical protein YP_002399276.1 3350712 D 585397 CDS YP_002399277.1 218691065 7140322 complement(3350924..3351175) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3351175 yqgD 7140322 yqgD Escherichia coli ED1a hypothetical protein YP_002399277.1 3350924 R 585397 CDS YP_002399278.1 218691066 7143354 3351231..3352385 1 NC_011745.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 3352385 metK 7143354 metK Escherichia coli ED1a S-adenosylmethionine synthetase YP_002399278.1 3351231 D 585397 CDS YP_002399279.1 218691067 7142257 3352821..3354215 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9182541; Product type t : transporter; D-galactose transporter 3354215 galP 7142257 galP Escherichia coli ED1a D-galactose transporter YP_002399279.1 3352821 D 585397 CDS YP_002399280.1 218691068 7143152 3354292..3354789 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7984428, 8113204; hypothetical protein 3354789 sprT 7143152 sprT Escherichia coli ED1a hypothetical protein YP_002399280.1 3354292 D 585397 CDS YP_002399281.1 218691069 7143834 3354884..3355591 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 72060411, 92335461, 4955462, 7867949, 8113204; Product type e : enzyme; DNA-specific endonuclease I 3355591 endA 7143834 endA Escherichia coli ED1a DNA-specific endonuclease I YP_002399281.1 3354884 D 585397 CDS YP_002399282.1 218691070 7139792 3355671..3356402 1 NC_011745.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 3356402 yggJ 7139792 yggJ Escherichia coli ED1a 16S ribosomal RNA methyltransferase RsmE YP_002399282.1 3355671 D 585397 CDS YP_002399283.1 218691071 7139623 3356415..3357365 1 NC_011745.1 catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione; glutathione synthetase 3357365 gshB 7139623 gshB Escherichia coli ED1a glutathione synthetase YP_002399283.1 3356415 D 585397 CDS YP_002399284.1 218691072 7143028 3357474..3358037 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3358037 yqgE 7143028 yqgE Escherichia coli ED1a hypothetical protein YP_002399284.1 3357474 D 585397 CDS YP_002399285.1 218691073 7143202 3358037..3358453 1 NC_011745.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 3358453 yqgF 7143202 yqgF Escherichia coli ED1a Holliday junction resolvase-like protein YP_002399285.1 3358037 D 585397 CDS YP_002399286.1 218691074 7143203 complement(3358627..3359607) 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1676385; Product type t : transporter; transporter 3359607 yggR 7143203 yggR Escherichia coli ED1a transporter YP_002399286.1 3358627 R 585397 CDS YP_002399287.1 218691075 7139628 3359625..3360329 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 3360329 yggS 7139628 yggS Escherichia coli ED1a hypothetical protein YP_002399287.1 3359625 D 585397 CDS YP_002399288.1 218691076 7139629 3360347..3360913 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3360913 yggT 7139629 yggT Escherichia coli ED1a hypothetical protein YP_002399288.1 3360347 D 585397 CDS YP_002399289.1 218691077 7139630 3360910..3361200 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12975589; hypothetical protein 3361200 yggU 7139630 yggU Escherichia coli ED1a hypothetical protein YP_002399289.1 3360910 D 585397 CDS YP_002399290.1 218691078 7139631 3361208..3361801 1 NC_011745.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; putative deoxyribonucleotide triphosphate pyrophosphatase 3361801 yggV 7139631 yggV Escherichia coli ED1a putative deoxyribonucleotide triphosphate pyrophosphatase YP_002399290.1 3361208 D 585397 CDS YP_002399291.1 218691079 7139632 3361794..3362930 1 NC_011745.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 3362930 yggW 7139632 yggW Escherichia coli ED1a coproporphyrinogen III oxidase YP_002399291.1 3361794 D 585397 CDS YP_002399292.1 218691080 7139633 complement(3362999..3364006) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3364006 yggM 7139633 yggM Escherichia coli ED1a hypothetical protein YP_002399292.1 3362999 R 585397 CDS YP_002399293.1 218691081 7139625 complement(3364123..3365169) 1 NC_011745.1 catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis; L-asparaginase II 3365169 ansB 7139625 ansB Escherichia coli ED1a L-asparaginase II YP_002399293.1 3364123 R 585397 CDS YP_002399294.1 218691082 7142584 complement(3365345..3366064) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11274153; hypothetical protein 3366064 yggN 7142584 yggN Escherichia coli ED1a hypothetical protein YP_002399294.1 3365345 R 585397 CDS YP_002399295.1 218691083 7139626 complement(3366248..3366574) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3366574 yggL 7139626 yggL Escherichia coli ED1a hypothetical protein YP_002399295.1 3366248 R 585397 CDS YP_002399296.1 218691084 7139624 complement(3366574..3367293) 1 NC_011745.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 3367293 trmB 7139624 trmB Escherichia coli ED1a tRNA (guanine-N(7)-)-methyltransferase YP_002399296.1 3366574 R 585397 CDS YP_002399297.1 218691085 7139622 3367454..3368506 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14730969, 20187555, 20316830, 20580749, 21438845, 90046892, 92409600, 9801309, 2001994, 2197596, 9846876; Product type e : enzyme; adenine DNA glycosylase 3368506 mutY 7139622 mutY Escherichia coli ED1a adenine DNA glycosylase YP_002399297.1 3367454 D 585397 CDS YP_002399298.1 218691086 7139059 3368534..3368809 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594836, 10493123, 9298646, 9868784; Product type f : factor; hypothetical protein 3368809 yggX 7139059 yggX Escherichia coli ED1a hypothetical protein YP_002399298.1 3368534 D 585397 CDS YP_002399299.1 218691087 7139634 3368874..3369953 1 NC_011745.1 Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase C 3369953 mltC 7139634 mltC Escherichia coli ED1a murein transglycosylase C YP_002399299.1 3368874 D 585397 CDS YP_002399300.1 218691088 7138992 3370155..3371411 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88029453, 90323001, 3311747; Product type t : transporter; nucleoside transporter 3371411 nupG 7138992 nupG Escherichia coli ED1a nucleoside transporter YP_002399300.1 3370155 D 585397 CDS YP_002399301.1 218691089 7139958 complement(3371460..3373595) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87222180, 87260820; Product type e : enzyme; ornithine decarboxylase 3373595 speC 7139958 speC Escherichia coli ED1a ornithine decarboxylase YP_002399301.1 3371460 R 585397 CDS YP_002399302.1 218691090 7143825 3373994..3374701 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3374701 yqgA 7143825 yqgA Escherichia coli ED1a hypothetical protein YP_002399302.1 3373994 D 585397 CDS YP_002399303.1 218691091 7140577 3375080..3376342 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; integrase 3376342 7140577 ECED1_3430 Escherichia coli ED1a integrase YP_002399303.1 3375080 D 585397 CDS YP_002399304.1 218691092 7141148 complement(3376706..3377023) 1 NC_011745.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS1 3377023 insB 7141148 insB Escherichia coli ED1a transposase ORF B (fragment), IS1 YP_002399304.1 3376706 R 585397 CDS YP_002399305.1 218691093 7141149 complement(3376942..3377217) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF 1, IS1 3377217 insA 7141149 insA Escherichia coli ED1a transposase ORF 1, IS1 YP_002399305.1 3376942 R 585397 CDS YP_002399306.1 218691094 7141126 complement(3377360..3378859) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative Amino acid transporter 3378859 7141126 ECED1_3434 Escherichia coli ED1a putative Amino acid transporter YP_002399306.1 3377360 R 585397 CDS YP_002399307.1 218691095 7141274 complement(3378934..3381303) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Orn/Lys/Arg decarboxylase 3381303 7141274 ECED1_3435 Escherichia coli ED1a putative Orn/Lys/Arg decarboxylase YP_002399307.1 3378934 R 585397 CDS YP_002399308.1 218691096 7141275 complement(3381408..3382877) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; hypothetical protein 3382877 7141275 ECED1_3436 Escherichia coli ED1a hypothetical protein YP_002399308.1 3381408 R 585397 CDS YP_002399309.1 218691097 7141276 3383130..3383402 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase InsA (ORF1) IS1 3383402 7141276 ECED1_3437 Escherichia coli ED1a transposase InsA (ORF1) IS1 YP_002399309.1 3383130 D 585397 CDS YP_002399310.1 218691098 7141277 3383429..3383788 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase InsB (ORF2) IS1 3383788 7141277 ECED1_3438 Escherichia coli ED1a transposase InsB (ORF2) IS1 YP_002399310.1 3383429 D 585397 CDS YP_002399311.1 218691099 7141278 3383824..3384048 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3384048 7141278 ECED1_3439 Escherichia coli ED1a hypothetical protein YP_002399311.1 3383824 D 585397 CDS YP_002399312.1 218691100 7141279 3384411..3384806 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative Zn-dependent alcohol dehydrogenases 3384806 7141279 ECED1_3440 Escherichia coli ED1a putative Zn-dependent alcohol dehydrogenases YP_002399312.1 3384411 D 585397 CDS YP_002399313.1 218691101 7141281 complement(3386302..3387837) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3387837 7141281 ECED1_3442 Escherichia coli ED1a hypothetical protein YP_002399313.1 3386302 R 585397 CDS YP_002399314.1 218691102 7141282 complement(3388076..3388474) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3388474 7141282 ECED1_3443 Escherichia coli ED1a hypothetical protein YP_002399314.1 3388076 R 585397 CDS YP_002399315.1 218691103 7141283 complement(3388546..3388983) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3388983 7141283 ECED1_3444 Escherichia coli ED1a hypothetical protein YP_002399315.1 3388546 R 585397 CDS YP_002399316.1 218691104 7141284 3389576..3389767 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3389767 7141284 ECED1_3445 Escherichia coli ED1a hypothetical protein YP_002399316.1 3389576 D 585397 CDS YP_002399317.1 218691105 7141285 complement(3389820..3390128) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3390128 7141285 ECED1_3446 Escherichia coli ED1a hypothetical protein YP_002399317.1 3389820 R 585397 CDS YP_002399318.1 218691106 7141286 complement(3390149..3390550) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3390550 7141286 ECED1_3447 Escherichia coli ED1a hypothetical protein YP_002399318.1 3390149 R 585397 CDS YP_002399319.1 218691107 7141287 3390999..3392117 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative propanol dehydrogenase 3392117 7141287 ECED1_3448 Escherichia coli ED1a putative propanol dehydrogenase YP_002399319.1 3390999 D 585397 CDS YP_002399320.1 218691108 7141288 3392257..3392943 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10498708; hypothetical protein 3392943 7141288 ECED1_3449 Escherichia coli ED1a hypothetical protein YP_002399320.1 3392257 D 585397 CDS YP_002399321.1 218691109 7141289 3392998..3393756 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative ethanolamine utilization protein (eutJ-like) 3393756 7141289 ECED1_3450 Escherichia coli ED1a putative ethanolamine utilization protein (eutJ-like) YP_002399321.1 3392998 D 585397 CDS YP_002399322.1 218691110 7141290 3393740..3394465 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3394465 7141290 ECED1_3451 Escherichia coli ED1a hypothetical protein YP_002399322.1 3393740 D 585397 CDS YP_002399323.1 218691111 7141291 3394477..3394746 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative Ethanolamine utilization protein (eutN-like) 3394746 7141291 ECED1_3452 Escherichia coli ED1a putative Ethanolamine utilization protein (eutN-like) YP_002399323.1 3394477 D 585397 CDS YP_002399324.1 218691112 7141292 3394774..3395271 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3395271 7141292 ECED1_3453 Escherichia coli ED1a hypothetical protein YP_002399324.1 3394774 D 585397 CDS YP_002399325.1 218691113 7141293 3395189..3396496 1 NC_011745.1 catalyzes the formation of propanoyl phosphate from propanoate and ATP; TdcD also has acetate kinase activities and functions in anaerobic threonine catabolism; propionate/acetate kinase 3396496 7141293 ECED1_3455 Escherichia coli ED1a propionate/acetate kinase YP_002399325.1 3395189 D 585397 CDS YP_002399326.1 218691114 7141294 3396730..3397062 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10498708; Product type ps : putative structure; putative propanediol utilization protein, polyhedral bodies (pduA-like) 3397062 7141294 ECED1_3456 Escherichia coli ED1a putative propanediol utilization protein, polyhedral bodies (pduA-like) YP_002399326.1 3396730 D 585397 CDS YP_002399327.1 218691115 7141295 3397084..3397869 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative propanediol utilization protein, polyhedral bodies (pduB-like) 3397869 7141295 ECED1_3457 Escherichia coli ED1a putative propanediol utilization protein, polyhedral bodies (pduB-like) YP_002399327.1 3397084 D 585397 CDS YP_002399328.1 218691116 7141296 3397930..3399456 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7868611, 10464203; Product type pe : putative enzyme; putative acetaldehyde/propionaldehyde dehydrogenase 3399456 7141296 ECED1_3458 Escherichia coli ED1a putative acetaldehyde/propionaldehyde dehydrogenase YP_002399328.1 3397930 D 585397 CDS YP_002399329.1 218691117 7141297 3399480..3399779 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3399779 7141297 ECED1_3459 Escherichia coli ED1a hypothetical protein YP_002399329.1 3399480 D 585397 CDS YP_002399330.1 218691118 7141298 3399655..3400365 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8626329; hypothetical protein 3400365 7141298 ECED1_3460 Escherichia coli ED1a hypothetical protein YP_002399330.1 3399655 D 585397 CDS YP_002399331.1 218691119 7141299 3400414..3402966 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Formate C-acetyltransferase 3402966 7141299 ECED1_3461 Escherichia coli ED1a putative Formate C-acetyltransferase YP_002399331.1 3400414 D 585397 CDS YP_002399332.1 218691120 7141300 3403075..3403992 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 3053170; Product type pe : putative enzyme; putative pyruvate formate-lyase 3-activating enzyme 3403992 7141300 ECED1_3462 Escherichia coli ED1a putative pyruvate formate-lyase 3-activating enzyme YP_002399332.1 3403075 D 585397 CDS YP_002399333.1 218691121 7141301 3404129..3405034 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative permease 3405034 7141301 ECED1_3463 Escherichia coli ED1a putative permease YP_002399333.1 3404129 D 585397 CDS YP_002399334.1 218691122 7141302 3405520..3406059 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative maturase-related protein 3406059 7141302 ECED1_3464 Escherichia coli ED1a putative maturase-related protein YP_002399334.1 3405520 D 585397 CDS YP_002399335.1 218691123 7141303 3406087..3406608 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative maturase-related protein 3406608 7141303 ECED1_3465 Escherichia coli ED1a putative maturase-related protein YP_002399335.1 3406087 D 585397 CDS YP_002399336.1 218691124 7141304 3406707..3406820 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 3406820 7141304 ECED1_3467 Escherichia coli ED1a hypothetical protein YP_002399336.1 3406707 D 585397 CDS YP_002399337.1 218691125 7140763 3407158..3408420 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3408420 7140763 ECED1_3468 Escherichia coli ED1a hypothetical protein YP_002399337.1 3407158 D 585397 CDS YP_002399338.1 218691126 7141306 3408437..3409492 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3409492 7141306 ECED1_3469 Escherichia coli ED1a hypothetical protein YP_002399338.1 3408437 D 585397 CDS YP_002399339.1 218691127 7141307 3409621..3410772 1 NC_011745.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 3410772 metK 7141307 metK Escherichia coli ED1a S-adenosylmethionine synthetase YP_002399339.1 3409621 D 585397 CDS YP_002399340.1 218691128 7142258 3410721..3411362 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3411362 7142258 ECED1_3472 Escherichia coli ED1a hypothetical protein YP_002399340.1 3410721 D 585397 CDS YP_002399341.1 218691129 7141309 complement(3411855..3412064) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3412064 7141309 ECED1_3474 Escherichia coli ED1a hypothetical protein YP_002399341.1 3411855 R 585397 CDS YP_002399342.1 218691130 7141310 complement(3412335..3412706) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3412706 7141310 ECED1_3475 Escherichia coli ED1a hypothetical protein YP_002399342.1 3412335 R 585397 CDS YP_002399343.1 218691131 7141311 complement(3412806..3413870) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3413870 7141311 ECED1_3476 Escherichia coli ED1a hypothetical protein YP_002399343.1 3412806 R 585397 CDS YP_002399344.1 218691132 7141160 3414392..3414583 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3414583 7141160 ECED1_3478 Escherichia coli ED1a hypothetical protein YP_002399344.1 3414392 D 585397 CDS YP_002399345.1 218691133 7141313 complement(3414619..3414852) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3414852 7141313 ECED1_3479 Escherichia coli ED1a hypothetical protein YP_002399345.1 3414619 R 585397 CDS YP_002399346.1 218691134 7141314 complement(3414921..3415685) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3415685 7141314 ECED1_3480 Escherichia coli ED1a hypothetical protein YP_002399346.1 3414921 R 585397 CDS YP_002399347.1 218691135 7141315 complement(3415843..3416574) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3416574 7141315 ECED1_3481 Escherichia coli ED1a hypothetical protein YP_002399347.1 3415843 R 585397 CDS YP_002399348.1 218691136 7141316 complement(3418027..3419250) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3419250 7141316 ECED1_3482 Escherichia coli ED1a hypothetical protein YP_002399348.1 3418027 R 585397 CDS YP_002399349.1 218691137 7141317 3419351..3420235 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative GTPase 3420235 7141317 ECED1_3483 Escherichia coli ED1a putative GTPase YP_002399349.1 3419351 D 585397 CDS YP_002399350.1 218691138 7141318 3421161..3421943 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3421943 7141318 ECED1_3485 Escherichia coli ED1a hypothetical protein YP_002399350.1 3421161 D 585397 CDS YP_002399351.1 218691139 7141319 3421949..3422182 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3422182 7141319 ECED1_3486 Escherichia coli ED1a hypothetical protein YP_002399351.1 3421949 D 585397 CDS YP_002399352.1 218691140 7141320 3422272..3423090 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3423090 7141320 ECED1_3487 Escherichia coli ED1a hypothetical protein YP_002399352.1 3422272 D 585397 CDS YP_002399353.1 218691141 7141321 3423182..3423667 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7519596; Product type pf : putative factor; putative antirestriction protein (klcA-like) 3423667 7141321 ECED1_3488 Escherichia coli ED1a putative antirestriction protein (klcA-like) YP_002399353.1 3423182 D 585397 CDS YP_002399354.1 218691142 7141322 3423713..3424159 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11053371; Product type pf : putative factor; putative DNA repair protein; CP4-44 prophage 3424159 yeeS 7141322 yeeS Escherichia coli ED1a putative DNA repair protein; CP4-44 prophage YP_002399354.1 3423713 D 585397 CDS YP_002399355.1 218691143 7139386 3424222..3424443 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 3424443 yeeT 7139386 yeeT Escherichia coli ED1a hypothetical protein YP_002399355.1 3424222 D 585397 CDS YP_002399356.1 218691144 7139391 3424443..3424556 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3424556 7139391 ECED1_3491 Escherichia coli ED1a hypothetical protein YP_002399356.1 3424443 D 585397 CDS YP_002399357.1 218691145 7141323 3424606..3424974 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594833; Product type h : extrachromosomal origin; CP4-44 prophage YeeV-YeeU toxin-antitoxin system toxin 3424974 yeeU 7141323 yeeU Escherichia coli ED1a CP4-44 prophage YeeV-YeeU toxin-antitoxin system toxin YP_002399357.1 3424606 D 585397 CDS YP_002399358.1 218691146 7139396 3425064..3425438 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594833; Product type h : extrachromosomal origin; toxin of the YeeV-YeeU toxin-antitoxin system; CP4-44 prophage 3425438 yeeV 7139396 yeeV Escherichia coli ED1a toxin of the YeeV-YeeU toxin-antitoxin system; CP4-44 prophage YP_002399358.1 3425064 D 585397 CDS YP_002399359.1 218691147 7139401 3425435..3425923 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3425923 yeeW 7139401 yeeW Escherichia coli ED1a hypothetical protein YP_002399359.1 3425435 D 585397 CDS YP_002399360.1 218691148 7139405 3425890..3426132 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3426132 7139405 ECED1_3495 Escherichia coli ED1a hypothetical protein YP_002399360.1 3425890 D 585397 CDS YP_002399361.1 218691149 7141325 complement(3427130..3427705) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3427705 7141325 ECED1_3497 Escherichia coli ED1a hypothetical protein YP_002399361.1 3427130 R 585397 CDS YP_002399362.1 218691150 7141326 complement(3427895..3428038) 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 3428038 7141326 ECED1_3498 Escherichia coli ED1a hypothetical protein YP_002399362.1 3427895 R 585397 CDS YP_002399363.1 218691151 7141327 complement(3428164..3429861) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3429861 7141327 ECED1_3499 Escherichia coli ED1a hypothetical protein YP_002399363.1 3428164 R 585397 CDS YP_002399364.1 218691152 7141328 complement(3429755..3431263) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3431263 7141328 ECED1_3500 Escherichia coli ED1a hypothetical protein YP_002399364.1 3429755 R 585397 CDS YP_002399365.1 218691153 7141329 3431803..3432033 1 NC_011745.1 Rac prophage; hypothetical protein 3432033 7141329 ECED1_3501 Escherichia coli ED1a hypothetical protein YP_002399365.1 3431803 D 585397 CDS YP_002399366.1 218691154 7141331 3433205..3433639 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative PilM protein 3433639 7141331 ECED1_3503 Escherichia coli ED1a putative PilM protein YP_002399366.1 3433205 D 585397 CDS YP_002399367.1 218691155 7141332 3433848..3435449 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative type IV pilus outer membrane secretin lipoprotein 3435449 7141332 ECED1_3504 Escherichia coli ED1a putative type IV pilus outer membrane secretin lipoprotein YP_002399367.1 3433848 D 585397 CDS YP_002399368.1 218691156 7141333 3435461..3436768 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative Pilin accessory protein pilO 3436768 7141333 ECED1_3505 Escherichia coli ED1a putative Pilin accessory protein pilO YP_002399368.1 3435461 D 585397 CDS YP_002399369.1 218691157 7141334 3436758..3437219 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12011003; Product type s : structure; Pilus type IV assembly protein 3437219 pilP 7141334 pilP Escherichia coli ED1a Pilus type IV assembly protein YP_002399369.1 3436758 D 585397 CDS YP_002399370.1 218691158 7144114 3437229..3438749 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; Type IV pilus (ATPase) 3438749 pilQ 7144114 pilQ Escherichia coli ED1a Type IV pilus (ATPase) YP_002399370.1 3437229 D 585397 CDS YP_002399371.1 218691159 7144115 3438685..3439851 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; membrane protein 3439851 7144115 ECED1_3508 Escherichia coli ED1a membrane protein YP_002399371.1 3438685 D 585397 CDS YP_002399372.1 218691160 7141335 3439903..3440436 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12011003; Product type pm : putative membrane component; major pillin subunit 3440436 pilS 7141335 pilS Escherichia coli ED1a major pillin subunit YP_002399372.1 3439903 D 585397 CDS YP_002399373.1 218691161 7144116 3440495..3440971 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; Peptidoglycan-binding-like protein 3440971 7144116 ECED1_3510 Escherichia coli ED1a Peptidoglycan-binding-like protein YP_002399373.1 3440495 D 585397 CDS YP_002399374.1 218691162 7141336 3440978..3441634 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12011003; Product type pm : putative membrane component; Prepilin peptidase 3441634 pilU 7141336 pilU Escherichia coli ED1a Prepilin peptidase YP_002399374.1 3440978 D 585397 CDS YP_002399375.1 218691163 7144117 3441631..3442974 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 3029698; Product type m : membrane component; minor pilin subunit 3442974 pilV 7144117 pilV Escherichia coli ED1a minor pilin subunit YP_002399375.1 3441631 D 585397 CDS YP_002399376.1 218691164 7138978 complement(3442979..3443368) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9603870; Product type m : membrane component; fragment of prepilin, shufflon protein (C-ter part) 3443368 pilV 7138978 pilV Escherichia coli ED1a fragment of prepilin, shufflon protein (C-ter part) YP_002399376.1 3442979 R 585397 CDS YP_002399377.1 218691165 7139060 3443371..3443604 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9603870; Product type m : membrane component; fragment of prepilin, shufflon protein (C-ter part) 3443604 pilV 7139060 pilV Escherichia coli ED1a fragment of prepilin, shufflon protein (C-ter part) YP_002399377.1 3443371 D 585397 CDS YP_002399378.1 218691166 7139061 complement(3443601..3443834) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9603870; Product type m : membrane component; fragment of pilV protein, Shufflon protein (C-ter part) 3443834 pilV 7139061 pilV Escherichia coli ED1a fragment of pilV protein, Shufflon protein (C-ter part) YP_002399378.1 3443601 R 585397 CDS YP_002399379.1 218691167 7139062 3443889..3445013 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 3065610; Product type e : enzyme; Shufflon-specific DNA recombinase 3445013 rci 7139062 rci Escherichia coli ED1a Shufflon-specific DNA recombinase YP_002399379.1 3443889 D 585397 CDS YP_002399380.1 218691168 7141262 complement(3445332..3445484) 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 3445484 7141262 ECED1_3518 Escherichia coli ED1a hypothetical protein YP_002399380.1 3445332 R 585397 CDS YP_002399381.1 218691169 7141337 3445574..3446395 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 3446395 7141337 ECED1_3519 Escherichia coli ED1a hypothetical protein YP_002399381.1 3445574 D 585397 CDS YP_002399382.1 218691170 7141338 3446437..3447687 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative plasmid transfer protein 3447687 traF 7141338 traF Escherichia coli ED1a putative plasmid transfer protein YP_002399382.1 3446437 D 585397 CDS YP_002399383.1 218691171 7141370 complement(3452520..3452912) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3452912 7141370 ECED1_3523 Escherichia coli ED1a hypothetical protein YP_002399383.1 3452520 R 585397 CDS YP_002399384.1 218691172 7141339 3453276..3453668 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3453668 7141339 ECED1_3524 Escherichia coli ED1a hypothetical protein YP_002399384.1 3453276 D 585397 CDS YP_002399385.1 218691173 7141340 3453728..3454009 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3454009 7141340 ECED1_3525 Escherichia coli ED1a hypothetical protein YP_002399385.1 3453728 D 585397 CDS YP_002399386.1 218691174 7141341 complement(3453999..3455792) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3455792 7141341 ECED1_3526 Escherichia coli ED1a hypothetical protein YP_002399386.1 3453999 R 585397 CDS YP_002399387.1 218691175 7141342 complement(3455947..3456684) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3456684 7141342 ECED1_3527 Escherichia coli ED1a hypothetical protein YP_002399387.1 3455947 R 585397 CDS YP_002399388.1 218691176 7141343 complement(3456810..3457607) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3457607 7141343 ECED1_3528 Escherichia coli ED1a hypothetical protein YP_002399388.1 3456810 R 585397 CDS YP_002399389.1 218691177 7141344 complement(3457619..3458599) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3458599 7141344 ECED1_3529 Escherichia coli ED1a hypothetical protein YP_002399389.1 3457619 R 585397 CDS YP_002399390.1 218691178 7141345 complement(3458674..3459135) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3459135 7141345 ECED1_3530 Escherichia coli ED1a hypothetical protein YP_002399390.1 3458674 R 585397 CDS YP_002399391.1 218691179 7141346 complement(3459185..3459808) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3459808 7141346 ECED1_3531 Escherichia coli ED1a hypothetical protein YP_002399391.1 3459185 R 585397 CDS YP_002399392.1 218691180 7140487 complement(3459591..3460025) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3460025 7140487 ECED1_3532 Escherichia coli ED1a hypothetical protein YP_002399392.1 3459591 R 585397 CDS YP_002399393.1 218691181 7141707 complement(3460061..3461143) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3461143 7141707 ECED1_3533 Escherichia coli ED1a hypothetical protein YP_002399393.1 3460061 R 585397 CDS YP_002399394.1 218691182 7141708 complement(3461137..3461556) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3461556 7141708 ECED1_3534 Escherichia coli ED1a hypothetical protein YP_002399394.1 3461137 R 585397 CDS YP_002399395.1 218691183 7141709 complement(3461673..3462152) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3462152 7141709 ECED1_3535 Escherichia coli ED1a hypothetical protein YP_002399395.1 3461673 R 585397 CDS YP_002399396.1 218691184 7141710 complement(3462253..3462639) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3462639 7141710 ECED1_3536 Escherichia coli ED1a hypothetical protein YP_002399396.1 3462253 R 585397 CDS YP_002399397.1 218691185 7141711 3463210..3463485 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF 1, IS1 3463485 insA 7141711 insA Escherichia coli ED1a transposase ORF 1, IS1 YP_002399397.1 3463210 D 585397 CDS YP_002399398.1 218691186 7141127 3463404..3463907 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF2, IS1 3463907 insB 7141127 insB Escherichia coli ED1a transposase ORF2, IS1 YP_002399398.1 3463404 D 585397 CDS YP_002399399.1 218691187 7141150 3464521..3465216 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3465216 7141150 ECED1_3539 Escherichia coli ED1a hypothetical protein YP_002399399.1 3464521 D 585397 CDS YP_002399400.1 218691188 7141712 complement(3465251..3465523) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3465523 7141712 ECED1_3540 Escherichia coli ED1a hypothetical protein YP_002399400.1 3465251 R 585397 CDS YP_002399401.1 218691189 7141713 complement(3465523..3466230) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3466230 7141713 ECED1_3541 Escherichia coli ED1a hypothetical protein YP_002399401.1 3465523 R 585397 CDS YP_002399402.1 218691190 7141714 3467642..3468058 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3468058 7141714 ECED1_3542 Escherichia coli ED1a hypothetical protein YP_002399402.1 3467642 D 585397 CDS YP_002399403.1 218691191 7141715 complement(3469375..3469638) 1 NC_011745.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 type B 3469638 rpmE2 7141715 rpmE2 Escherichia coli ED1a 50S ribosomal protein L31 type B YP_002399403.1 3469375 R 585397 CDS YP_002399404.1 218691192 7140955 complement(3469747..3469893) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3469893 7140955 ECED1_3544 Escherichia coli ED1a hypothetical protein YP_002399404.1 3469747 R 585397 CDS YP_002399405.1 218691193 7141716 3470064..3470795 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type m : membrane component; conjugal transfer surface exclusion protein TraT 3470795 7141716 ECED1_3545 Escherichia coli ED1a conjugal transfer surface exclusion protein TraT YP_002399405.1 3470064 D 585397 CDS YP_002399406.1 218691194 7141717 complement(3470843..3471847) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8451198, 8276869; Product type pe : putative enzyme; putative Restriction enzyme subunit beta 3471847 7141717 ECED1_3546 Escherichia coli ED1a putative Restriction enzyme subunit beta YP_002399406.1 3470843 R 585397 CDS YP_002399407.1 218691195 7141718 complement(3471816..3473705) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8451198, 8276869; Product type pe : putative enzyme; putative Restriction enzyme subunit alpha 3473705 7141718 ECED1_3547 Escherichia coli ED1a putative Restriction enzyme subunit alpha YP_002399407.1 3471816 R 585397 CDS YP_002399408.1 218691196 7143101 complement(3475015..3475890) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3475890 7143101 ECED1_3549 Escherichia coli ED1a hypothetical protein YP_002399408.1 3475015 R 585397 CDS YP_002399409.1 218691197 7141720 complement(3476314..3476583) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3476583 7141720 ECED1_3550 Escherichia coli ED1a hypothetical protein YP_002399409.1 3476314 R 585397 CDS YP_002399410.1 218691198 7141721 complement(3476932..3478980) 1 NC_011745.1 iron-responsive element (ireA); ireA gene is located on pathogenicity island I (PAI I); outer membrane protein; putative iron-regulated outer membrane virulence protein 3478980 ireA 7141721 ireA Escherichia coli ED1a putative iron-regulated outer membrane virulence protein YP_002399410.1 3476932 R 585397 CDS YP_002399411.1 218691199 7142447 complement(3479148..3479303) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3479303 7142447 ECED1_3552 Escherichia coli ED1a hypothetical protein YP_002399411.1 3479148 R 585397 CDS YP_002399412.1 218691200 7141722 3479803..3480057 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3480057 7141722 ECED1_3553 Escherichia coli ED1a hypothetical protein YP_002399412.1 3479803 D 585397 CDS YP_002399413.1 218691201 7141723 complement(3480094..3481614) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3481614 7141723 ECED1_3554 Escherichia coli ED1a hypothetical protein YP_002399413.1 3480094 R 585397 CDS YP_002399414.1 218691202 7141724 complement(3481618..3482010) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3482010 7141724 ECED1_3555 Escherichia coli ED1a hypothetical protein YP_002399414.1 3481618 R 585397 CDS YP_002399415.1 218691203 7141725 complement(3481976..3483457) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3483457 7141725 ECED1_3556 Escherichia coli ED1a hypothetical protein YP_002399415.1 3481976 R 585397 CDS YP_002399416.1 218691204 7141726 complement(3483409..3484383) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3484383 7141726 ECED1_3557 Escherichia coli ED1a hypothetical protein YP_002399416.1 3483409 R 585397 CDS YP_002399417.1 218691205 7141727 complement(3484380..3484778) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3484778 7141727 ECED1_3558 Escherichia coli ED1a hypothetical protein YP_002399417.1 3484380 R 585397 CDS YP_002399418.1 218691206 7141728 complement(3484642..3484920) 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 3484920 7141728 ECED1_3559 Escherichia coli ED1a hypothetical protein YP_002399418.1 3484642 R 585397 CDS YP_002399419.1 218691207 7141729 complement(3485005..3487095) 1 NC_011745.1 IrgA-homologue adhesin (Iha); TonB-dependent; acts as a specific receptor of enterobactin; fur-regulated; urovirulence factor; bifunctional enterobactin receptor/adhesin protein 3487095 7141729 ECED1_3560 Escherichia coli ED1a bifunctional enterobactin receptor/adhesin protein YP_002399419.1 3485005 R 585397 CDS YP_002399420.1 218691208 7141730 complement(3487487..3487873) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3487873 7141730 ECED1_3561 Escherichia coli ED1a hypothetical protein YP_002399420.1 3487487 R 585397 CDS YP_002399421.1 218691209 7141731 complement(3487870..3490686) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative plasmid-related outer membrane ATPase 3490686 7141731 ECED1_3562 Escherichia coli ED1a putative plasmid-related outer membrane ATPase YP_002399421.1 3487870 R 585397 CDS YP_002399422.1 218691210 7141732 complement(3490686..3491099) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; putative lipoprotein 3491099 7141732 ECED1_3563 Escherichia coli ED1a putative lipoprotein YP_002399422.1 3490686 R 585397 CDS YP_002399423.1 218691211 7141733 complement(3491117..3492595) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3492595 7141733 ECED1_3564 Escherichia coli ED1a hypothetical protein YP_002399423.1 3491117 R 585397 CDS YP_002399424.1 218691212 7141734 complement(3492585..3493493) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3493493 7141734 ECED1_3565 Escherichia coli ED1a hypothetical protein YP_002399424.1 3492585 R 585397 CDS YP_002399425.1 218691213 7141735 complement(3493490..3494137) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3494137 7141735 ECED1_3566 Escherichia coli ED1a hypothetical protein YP_002399425.1 3493490 R 585397 CDS YP_002399426.1 218691214 7141736 complement(3494134..3494511) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3494511 7141736 ECED1_3567 Escherichia coli ED1a hypothetical protein YP_002399426.1 3494134 R 585397 CDS YP_002399427.1 218691215 7141737 complement(3494518..3494895) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3494895 7141737 ECED1_3568 Escherichia coli ED1a hypothetical protein YP_002399427.1 3494518 R 585397 CDS YP_002399428.1 218691216 7141738 complement(3494926..3495168) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3495168 7141738 ECED1_3569 Escherichia coli ED1a hypothetical protein YP_002399428.1 3494926 R 585397 CDS YP_002399429.1 218691217 7141739 complement(3495168..3495530) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3495530 7141739 ECED1_3570 Escherichia coli ED1a hypothetical protein YP_002399429.1 3495168 R 585397 CDS YP_002399430.1 218691218 7141740 3495622..3496188 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3496188 7141740 ECED1_3571 Escherichia coli ED1a hypothetical protein YP_002399430.1 3495622 D 585397 CDS YP_002399431.1 218691219 7141741 complement(3496223..3496387) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3496387 7141741 ECED1_3572 Escherichia coli ED1a hypothetical protein YP_002399431.1 3496223 R 585397 CDS YP_002399432.1 218691220 7141742 complement(3496643..3497410) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3497410 7141742 ECED1_3573 Escherichia coli ED1a hypothetical protein YP_002399432.1 3496643 R 585397 CDS YP_002399433.1 218691221 7141743 complement(3497385..3499502) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative plasmid transfer protein 3499502 7141743 ECED1_3574 Escherichia coli ED1a putative plasmid transfer protein YP_002399433.1 3497385 R 585397 CDS YP_002399434.1 218691222 7141744 complement(3499495..3500325) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3500325 7141744 ECED1_3575 Escherichia coli ED1a hypothetical protein YP_002399434.1 3499495 R 585397 CDS YP_002399435.1 218691223 7141745 complement(3500297..3500899) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme; putative restriction endonuclease 3500899 7141745 ECED1_3576 Escherichia coli ED1a putative restriction endonuclease YP_002399435.1 3500297 R 585397 CDS YP_002399436.1 218691224 7141746 complement(3500896..3501426) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3501426 7141746 ECED1_3577 Escherichia coli ED1a hypothetical protein YP_002399436.1 3500896 R 585397 CDS YP_002399437.1 218691225 7141747 complement(3501423..3502085) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Lytic transglycosylase, catalytic 3502085 7141747 ECED1_3578 Escherichia coli ED1a putative Lytic transglycosylase, catalytic YP_002399437.1 3501423 R 585397 CDS YP_002399438.1 218691226 7141748 complement(3502064..3502786) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3502786 7141748 ECED1_3579 Escherichia coli ED1a hypothetical protein YP_002399438.1 3502064 R 585397 CDS YP_002399439.1 218691227 7141749 complement(3502791..3503558) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3503558 7141749 ECED1_3580 Escherichia coli ED1a hypothetical protein YP_002399439.1 3502791 R 585397 CDS YP_002399440.1 218691228 7144113 complement(3504291..3504500) 1 NC_011745.1 Evidence 7 : Gene remnant; hypothetical protein 3504500 7144113 ECED1_3582 Escherichia coli ED1a hypothetical protein YP_002399440.1 3504291 R 585397 CDS YP_002399441.1 218691229 7140764 complement(3505063..3506586) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative reverse transcriptase protein from putative prophage or plasmid 3506586 7140764 ECED1_3584 Escherichia coli ED1a putative reverse transcriptase protein from putative prophage or plasmid YP_002399441.1 3505063 R 585397 CDS YP_002399442.1 218691230 7141754 complement(3508002..3508181) 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 3508181 7141754 ECED1_3587 Escherichia coli ED1a hypothetical protein YP_002399442.1 3508002 R 585397 CDS YP_002399443.1 218691231 7141755 complement(3508255..3509214) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3509214 7141755 ECED1_3588 Escherichia coli ED1a hypothetical protein YP_002399443.1 3508255 R 585397 CDS YP_002399444.1 218691232 7141756 complement(3509261..3509818) 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type cp : cell process; Single-stranded DNA-binding protein 3509818 ssb 7141756 ssb Escherichia coli ED1a Single-stranded DNA-binding protein YP_002399444.1 3509261 R 585397 CDS YP_002399445.1 218691233 7143846 complement(3509831..3510052) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3510052 7143846 ECED1_3590 Escherichia coli ED1a hypothetical protein YP_002399445.1 3509831 R 585397 CDS YP_002399446.1 218691234 7141757 complement(3510146..3510559) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3510559 7141757 ECED1_3591 Escherichia coli ED1a hypothetical protein YP_002399446.1 3510146 R 585397 CDS YP_002399447.1 218691235 7141758 3510670..3510825 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3510825 7141758 ECED1_3592 Escherichia coli ED1a hypothetical protein YP_002399447.1 3510670 D 585397 CDS YP_002399448.1 218691236 7141759 3511600..3512619 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8253690; Product type e : enzyme; Polysialic acid capsule expression protein 3512619 kpsF 7141759 kpsF Escherichia coli ED1a Polysialic acid capsule expression protein YP_002399448.1 3511600 D 585397 CDS YP_002399449.1 218691237 7142517 3512691..3513839 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8253690; Product type t : transporter; Capsule polysaccharide export inner-membrane protein 3513839 kpsE 7142517 kpsE Escherichia coli ED1a Capsule polysaccharide export inner-membrane protein YP_002399449.1 3512691 D 585397 CDS YP_002399450.1 218691238 7142516 3513860..3515539 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8021185; Product type t : transporter; Polysialic acid transport protein 3515539 kpsD 7142516 kpsD Escherichia coli ED1a Polysialic acid transport protein YP_002399450.1 3513860 D 585397 CDS YP_002399451.1 218691239 7142515 3515549..3516289 1 NC_011745.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 3516289 kpsU 7142515 kpsU Escherichia coli ED1a 3-deoxy-manno-octulosonate cytidylyltransferase YP_002399451.1 3515549 D 585397 CDS YP_002399452.1 218691240 7142521 3516286..3518313 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8397187, 8326861; Product type t : transporter; Capsule polysaccharide export protein 3518313 kpsC 7142521 kpsC Escherichia coli ED1a Capsule polysaccharide export protein YP_002399452.1 3516286 D 585397 CDS YP_002399453.1 218691241 7142514 3518348..3519586 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8397187, 8326861; Product type t : transporter; Capsule polysaccharide export protein 3519586 kpsS 7142514 kpsS Escherichia coli ED1a Capsule polysaccharide export protein YP_002399453.1 3518348 D 585397 CDS YP_002399454.1 218691242 7142519 complement(3519707..3520348) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3520348 7142519 ECED1_3599 Escherichia coli ED1a hypothetical protein YP_002399454.1 3519707 R 585397 CDS YP_002399455.1 218691243 7141760 complement(3520436..3523888) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative hydrolase 3523888 7141760 ECED1_3600 Escherichia coli ED1a putative hydrolase YP_002399455.1 3520436 R 585397 CDS YP_002399456.1 218691244 7141761 complement(3524137..3524805) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1856162, 8051103, 2082146; Product type t : transporter; Polysialic acid transport ATP-binding protein kpsT 3524805 kpsT 7141761 kpsT Escherichia coli ED1a Polysialic acid transport ATP-binding protein kpsT YP_002399456.1 3524137 R 585397 CDS YP_002399457.1 218691245 7142520 complement(3524802..3525638) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1856162, 7715449; Product type t : transporter; Polysialic acid transport protein 3525638 kpsM 7142520 kpsM Escherichia coli ED1a Polysialic acid transport protein YP_002399457.1 3524802 R 585397 CDS YP_002399458.1 218691246 7142518 complement(3526751..3527287) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative general secretion pathway protein YghD 3527287 yghD 7142518 yghD Escherichia coli ED1a putative general secretion pathway protein YghD YP_002399458.1 3526751 R 585397 CDS YP_002399459.1 218691247 7139637 complement(3527289..3528467) 1 NC_011745.1 similar to general secretory pathway protein L; GspL-like protein 3528467 yghE 7139637 yghE Escherichia coli ED1a GspL-like protein YP_002399459.1 3527289 R 585397 CDS YP_002399460.1 218691248 7139638 complement(3528464..3529441) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; GspK-like type II secretion protein 3529441 7139638 ECED1_3605 Escherichia coli ED1a GspK-like type II secretion protein YP_002399460.1 3528464 R 585397 CDS YP_002399461.1 218691249 7141762 complement(3529438..3530043) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3530043 7141762 ECED1_3606 Escherichia coli ED1a hypothetical protein YP_002399461.1 3529438 R 585397 CDS YP_002399462.1 218691250 7141763 complement(3530040..3530411) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative GspI-like type II secretion protein 3530411 7141763 ECED1_3607 Escherichia coli ED1a putative GspI-like type II secretion protein YP_002399462.1 3530040 R 585397 CDS YP_002399463.1 218691251 7141764 complement(3530408..3530971) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3530971 7141764 ECED1_3608 Escherichia coli ED1a hypothetical protein YP_002399463.1 3530408 R 585397 CDS YP_002399464.1 218691252 7141765 complement(3530975..3531457) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative general secretion pathway protein G (epsG-like) 3531457 7141765 ECED1_3609 Escherichia coli ED1a putative general secretion pathway protein G (epsG-like) YP_002399464.1 3530975 R 585397 CDS YP_002399465.1 218691253 7141766 complement(3531447..3532670) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; General secretion pathway protein F 3532670 epsF 7141766 epsF Escherichia coli ED1a General secretion pathway protein F YP_002399465.1 3531447 R 585397 CDS YP_002399466.1 218691254 7139806 complement(3532670..3534163) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; general secretion pathway protein E 3534163 epsE 7139806 epsE Escherichia coli ED1a general secretion pathway protein E YP_002399466.1 3532670 R 585397 CDS YP_002399467.1 218691255 7139805 complement(3534163..3536223) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; general secretion pathway protein D 3536223 epsD 7139805 epsD Escherichia coli ED1a general secretion pathway protein D YP_002399467.1 3534163 R 585397 CDS YP_002399468.1 218691256 7139804 complement(3536253..3537212) 1 NC_011745.1 part of the general (type II) secretion pathway (GSP), a signal sequence-dependent process responsible for protein export; involved in trans-location of exoproteins from the cytoplasm to the periplasm; putative type II secretion protein GspC 3537212 yghF 7139804 yghF Escherichia coli ED1a putative type II secretion protein GspC YP_002399468.1 3536253 R 585397 CDS YP_002399469.1 218691257 7139639 complement(3537230..3537640) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3537640 yghG 7139639 yghG Escherichia coli ED1a hypothetical protein YP_002399469.1 3537230 R 585397 CDS YP_002399470.1 218691258 7139640 complement(3537706..3538515) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98175453; Product type e : enzyme; bifunctional prepilin leader peptidase and methylase 3538515 pppA 7139640 pppA Escherichia coli ED1a bifunctional prepilin leader peptidase and methylase YP_002399470.1 3537706 R 585397 CDS YP_002399471.1 218691259 7139108 complement(3538679..3543259) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 1644747; Product type lp : lipoprotein; inner membrane lipoprotein 3543259 yghJ 7139108 yghJ Escherichia coli ED1a inner membrane lipoprotein YP_002399471.1 3538679 R 585397 CDS YP_002399472.1 218691260 7139641 complement(3543725..3545407) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11785976, 21178909, 11283302; Product type t : transporter; glycolate transporter 3545407 yghK 7139641 yghK Escherichia coli ED1a glycolate transporter YP_002399472.1 3543725 R 585397 CDS YP_002399473.1 218691261 7140471 complement(3545763..3547934) 1 NC_011745.1 catalyzes the formation of malate from glyoxylate and acetyl-CoA; malate synthase G 3547934 glcB 7140471 glcB Escherichia coli ED1a malate synthase G YP_002399473.1 3545763 R 585397 CDS YP_002399474.1 218691262 7143178 complement(3547956..3548360) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3548360 glcG 7143178 glcG Escherichia coli ED1a hypothetical protein YP_002399474.1 3547956 R 585397 CDS YP_002399475.1 218691263 7143182 complement(3549597..3550649) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96178972, 8606183; Product type e : enzyme; glycolate oxidase FAD binding subunit 3550649 glcE 7143182 glcE Escherichia coli ED1a glycolate oxidase FAD binding subunit YP_002399475.1 3549597 R 585397 CDS YP_002399476.1 218691264 7143181 complement(3550649..3552148) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96178972, 8606183; Product type e : enzyme; glycolate oxidase subunit GlcD 3552148 glcD 7143181 glcD Escherichia coli ED1a glycolate oxidase subunit GlcD YP_002399476.1 3550649 R 585397 CDS YP_002399477.1 218691265 7143180 3552399..3553163 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96178972, 9880556, 8606183; Product type r : regulator; DNA-binding transcriptional regulator GlcC 3553163 glcC 7143180 glcC Escherichia coli ED1a DNA-binding transcriptional regulator GlcC YP_002399477.1 3552399 D 585397 CDS YP_002399478.1 218691266 7143179 complement(3553170..3554312) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3554312 yghO 7143179 yghO Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002399478.1 3553170 R 585397 CDS YP_002399479.1 218691267 7141767 3556404..3557318 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative epimerase 3557318 7141767 ECED1_3626 Escherichia coli ED1a putative epimerase YP_002399479.1 3556404 D 585397 CDS YP_002399480.1 218691268 7141768 3557350..3557598 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3557598 7141768 ECED1_3627 Escherichia coli ED1a hypothetical protein YP_002399480.1 3557350 D 585397 CDS YP_002399481.1 218691269 7141769 3557598..3558770 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative 8-amino-7-oxononanoate synthase 3558770 7141769 ECED1_3628 Escherichia coli ED1a putative 8-amino-7-oxononanoate synthase YP_002399481.1 3557598 D 585397 CDS YP_002399482.1 218691270 7141770 complement(3558805..3559965) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3559965 7141770 ECED1_3629 Escherichia coli ED1a hypothetical protein YP_002399482.1 3558805 R 585397 CDS YP_002399483.1 218691271 7141771 complement(3559881..3560951) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3560951 7141771 ECED1_3630 Escherichia coli ED1a hypothetical protein YP_002399483.1 3559881 R 585397 CDS YP_002399484.1 218691272 7141772 complement(3560982..3561542) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 3561542 7141772 ECED1_3631 Escherichia coli ED1a putative transcriptional regulator YP_002399484.1 3560982 R 585397 CDS YP_002399485.1 218691273 7141773 complement(3561542..3562378) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3562378 7141773 ECED1_3632 Escherichia coli ED1a hypothetical protein YP_002399485.1 3561542 R 585397 CDS YP_002399486.1 218691274 7141774 complement(3562378..3563727) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 3563727 7141774 ECED1_3633 Escherichia coli ED1a hypothetical protein YP_002399486.1 3562378 R 585397 CDS YP_002399487.1 218691275 7141775 complement(3563773..3564531) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3564531 yghR 7141775 yghR Escherichia coli ED1a hypothetical protein YP_002399487.1 3563773 R 585397 CDS YP_002399488.1 218691276 7139644 complement(3564563..3565276) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3565276 yghS 7139644 yghS Escherichia coli ED1a hypothetical protein YP_002399488.1 3564563 R 585397 CDS YP_002399489.1 218691277 7139645 3565451..3566143 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3566143 yghT 7139645 yghT Escherichia coli ED1a hypothetical protein YP_002399489.1 3565451 D 585397 CDS YP_002399490.1 218691278 7139646 complement(3566192..3567691) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21336523, 21382172, 7775463; Product type t : transporter; phosphate transporter 3567691 pitB 7139646 pitB Escherichia coli ED1a phosphate transporter YP_002399490.1 3566192 R 585397 CDS YP_002399491.1 218691279 7139066 complement(3567983..3569842) 1 NC_011745.1 catalyzes the formation of glutathionylspermidine from glutathione and spermidine; also catalyzes the reverse reaction; bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase 3569842 gss 7139066 gss Escherichia coli ED1a bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase YP_002399491.1 3567983 R 585397 CDS YP_002399492.1 218691280 7139841 3570047..3570913 1 NC_011745.1 YghU; B2989; one of eight putative glutathione transferase proteins from E. coli; putative glutathione S-transferase YghU 3570913 yghU 7139841 yghU Escherichia coli ED1a putative glutathione S-transferase YghU YP_002399492.1 3570047 D 585397 CDS YP_002399493.1 218691281 7139647 complement(3571055..3571303) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92215587, 94292472, 8021226; Product type pf : putative factor; hydrogenase 2 accessory protein HypG 3571303 hybG 7139647 hybG Escherichia coli ED1a hydrogenase 2 accessory protein HypG YP_002399493.1 3571055 R 585397 CDS YP_002399494.1 218691282 7140192 complement(3571316..3571657) 1 NC_011745.1 plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein HybF 3571657 hybF 7140192 hybF Escherichia coli ED1a hydrogenase nickel incorporation protein HybF YP_002399494.1 3571316 R 585397 CDS YP_002399495.1 218691283 7140191 complement(3571650..3572138) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94292472, 8021226; Product type f : factor; hydrogenase 2-specific chaperone 3572138 hybE 7140191 hybE Escherichia coli ED1a hydrogenase 2-specific chaperone YP_002399495.1 3571650 R 585397 CDS YP_002399496.1 218691284 7140190 complement(3572131..3572625) 1 NC_011745.1 protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC); hydrogenase 2 maturation endopeptidase 3572625 hybD 7140190 hybD Escherichia coli ED1a hydrogenase 2 maturation endopeptidase YP_002399496.1 3572131 R 585397 CDS YP_002399497.1 218691285 7140189 complement(3572625..3574328) 1 NC_011745.1 involved in hydrogen uptake; hydrogenase 2 large subunit 3574328 hybC 7140189 hybC Escherichia coli ED1a hydrogenase 2 large subunit YP_002399497.1 3572625 R 585397 CDS YP_002399498.1 218691286 7140188 complement(3574325..3575503) 1 NC_011745.1 HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits; putative hydrogenase 2 b cytochrome subunit 3575503 hybB 7140188 hybB Escherichia coli ED1a putative hydrogenase 2 b cytochrome subunit YP_002399498.1 3574325 R 585397 CDS YP_002399499.1 218691287 7140187 complement(3575493..3576479) 1 NC_011745.1 Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2; hydrogenase 2 protein HybA 3576479 hybA 7140187 hybA Escherichia coli ED1a hydrogenase 2 protein HybA YP_002399499.1 3575493 R 585397 CDS YP_002399500.1 218691288 7140186 complement(3576482..3577600) 1 NC_011745.1 involved in hydrogen uptake; hydrogenase 2 small subunit 3577600 hybO 7140186 hybO Escherichia coli ED1a hydrogenase 2 small subunit YP_002399500.1 3576482 R 585397 CDS YP_002399501.1 218691289 7140193 complement(3577607..3577792) 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 3577792 7140193 ECED1_3648 Escherichia coli ED1a hypothetical protein YP_002399501.1 3577607 R 585397 CDS YP_002399502.1 218691290 7141776 complement(3577789..3578076) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3578076 yghW 7141776 yghW Escherichia coli ED1a hypothetical protein YP_002399502.1 3577789 R 585397 CDS YP_002399503.1 218691291 7139648 complement(3578195..3579121) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3579121 7139648 ECED1_3650 Escherichia coli ED1a hypothetical protein YP_002399503.1 3578195 R 585397 CDS YP_002399504.1 218691292 7141777 3579239..3580279 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12583903; Product type e : enzyme; aldo-keto reductase 3580279 yghZ 7141777 yghZ Escherichia coli ED1a aldo-keto reductase YP_002399504.1 3579239 D 585397 CDS YP_002399505.1 218691293 7139649 complement(3580319..3580813) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3580813 yqhA 7139649 yqhA Escherichia coli ED1a hypothetical protein YP_002399505.1 3580319 R 585397 CDS YP_002399506.1 218691294 7143204 3581004..3581888 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; oxidoreductase 3581888 yghA 7143204 yghA Escherichia coli ED1a oxidoreductase YP_002399506.1 3581004 D 585397 CDS YP_002399507.1 218691295 7139635 complement(3581927..3582352) 1 NC_011745.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbD 3582352 exbD 7139635 exbD Escherichia coli ED1a biopolymer transport protein ExbD YP_002399507.1 3581927 R 585397 CDS YP_002399508.1 218691296 7139831 complement(3582359..3583093) 1 NC_011745.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbB 3583093 exbB 7139831 exbB Escherichia coli ED1a biopolymer transport protein ExbB YP_002399508.1 3582359 R 585397 CDS YP_002399509.1 218691297 7139830 complement(3583086..3583241) 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 3583241 7139830 ECED1_3657 Escherichia coli ED1a hypothetical protein YP_002399509.1 3583086 R 585397 CDS YP_002399510.1 218691298 7141778 3583345..3584532 1 NC_011745.1 catalyzes the formation of L-homocysteine from cystathionine; cystathionine beta-lyase 3584532 metC 7141778 metC Escherichia coli ED1a cystathionine beta-lyase YP_002399510.1 3583345 D 585397 CDS YP_002399511.1 218691299 7142250 3584672..3585331 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3585331 yghB 7142250 yghB Escherichia coli ED1a hypothetical protein YP_002399511.1 3584672 D 585397 CDS YP_002399512.1 218691300 7139636 complement(3585371..3586327) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3586327 yqhC 7139636 yqhC Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002399512.1 3585371 R 585397 CDS YP_002399513.1 218691301 7143205 3586464..3587627 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15327949; Product type e : enzyme; alcohol dehydrogenase, NAD(P)-dependent 3587627 yqhD 7143205 yqhD Escherichia coli ED1a alcohol dehydrogenase, NAD(P)-dependent YP_002399513.1 3586464 D 585397 CDS YP_002399514.1 218691302 7143206 3587732..3588559 1 NC_011745.1 methylglyoxal reductase/#-keto ester reductase; catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; also catalyzes the reduction of methylglyoxal, ethyl-2-methylacetoacetate and ethyl-acetoacetate; 2,5-diketo-D-gluconate reductase A 3588559 dkgA 7143206 dkgA Escherichia coli ED1a 2,5-diketo-D-gluconate reductase A YP_002399514.1 3587732 D 585397 CDS YP_002399515.1 218691303 7140494 3588759..3589688 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3589688 yqhG 7140494 yqhG Escherichia coli ED1a hypothetical protein YP_002399515.1 3588759 D 585397 CDS YP_002399516.1 218691304 7143207 complement(3589623..3590126) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF2, IS1 3590126 insB 7143207 insB Escherichia coli ED1a transposase ORF2, IS1 YP_002399516.1 3589623 R 585397 CDS YP_002399517.1 218691305 7141151 complement(3590045..3590320) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF 1, IS1 3590320 insA 7141151 insA Escherichia coli ED1a transposase ORF 1, IS1 YP_002399517.1 3590045 R 585397 CDS YP_002399518.1 218691306 7141128 3590512..3590769 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; putative outer membrane lipoprotein 3590769 yqhH 7141128 yqhH Escherichia coli ED1a putative outer membrane lipoprotein YP_002399518.1 3590512 D 585397 CDS YP_002399519.1 218691307 7143208 complement(3590811..3593030) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3593030 ygiQ 7143208 ygiQ Escherichia coli ED1a hypothetical protein YP_002399519.1 3590811 R 585397 CDS YP_002399520.1 218691308 7139658 3593282..3594031 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative regulator 3594031 7139658 ECED1_3668 Escherichia coli ED1a putative regulator YP_002399520.1 3593282 D 585397 CDS YP_002399521.1 218691309 7141779 3594356..3595828 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Fructuronate reductase 3595828 7141779 ECED1_3669 Escherichia coli ED1a putative Fructuronate reductase YP_002399521.1 3594356 D 585397 CDS YP_002399522.1 218691310 7141780 3595825..3596841 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative L-threonine 3-dehydrogenase 3596841 7141780 ECED1_3670 Escherichia coli ED1a putative L-threonine 3-dehydrogenase YP_002399522.1 3595825 D 585397 CDS YP_002399523.1 218691311 7141781 3596852..3597862 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Ureidoglycolate dehydrogenase 3597862 7141781 ECED1_3671 Escherichia coli ED1a Ureidoglycolate dehydrogenase YP_002399523.1 3596852 D 585397 CDS YP_002399524.1 218691312 7141782 3597935..3598918 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative c4-dicarboxylate transport system binding protein 3598918 7141782 ECED1_3672 Escherichia coli ED1a putative c4-dicarboxylate transport system binding protein YP_002399524.1 3597935 D 585397 CDS YP_002399525.1 218691313 7141783 3598960..3599442 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative TRAP-type C4-dicarboxylate transport system small permease component 3599442 7141783 ECED1_3673 Escherichia coli ED1a putative TRAP-type C4-dicarboxylate transport system small permease component YP_002399525.1 3598960 D 585397 CDS YP_002399526.1 218691314 7141784 3599411..3600745 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; c4-dicarboxylate permease 3600745 ygiK 7141784 ygiK Escherichia coli ED1a c4-dicarboxylate permease YP_002399526.1 3599411 D 585397 CDS YP_002399527.1 218691315 7139654 complement(3600816..3602228) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88314889, 1557036, 9298646; Product type r : regulator; repressor protein for FtsI 3602228 sufI 7139654 sufI Escherichia coli ED1a repressor protein for FtsI YP_002399527.1 3600816 R 585397 CDS YP_002399528.1 218691316 7141495 complement(3602303..3603040) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92212294, 1557036; Product type e : enzyme; 1-acyl-sn-glycerol-3-phosphate acyltransferase 3603040 plsC 7141495 plsC Escherichia coli ED1a 1-acyl-sn-glycerol-3-phosphate acyltransferase YP_002399528.1 3602303 R 585397 CDS YP_002399529.1 218691317 7139070 complement(3603089..3603244) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3603244 7139070 ECED1_3677 Escherichia coli ED1a hypothetical protein YP_002399529.1 3603089 R 585397 CDS YP_002399530.1 218691318 7141785 complement(3603275..3605533) 1 NC_011745.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 3605533 parC 7141785 parC Escherichia coli ED1a DNA topoisomerase IV subunit A YP_002399530.1 3603275 R 585397 CDS YP_002399531.1 218691319 7144044 complement(3605671..3607278) 1 NC_011745.1 YgiS; uncharacterized periplasmic protein that seems to be part of a binding-protein-dependent transport system; putative binding protein 3607278 ygiS 7144044 ygiS Escherichia coli ED1a putative binding protein YP_002399531.1 3605671 R 585397 CDS YP_002399532.1 218691320 7139659 complement(3607387..3607869) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 3607869 ygiV 7139659 ygiV Escherichia coli ED1a putative transcriptional regulator YP_002399532.1 3607387 R 585397 CDS YP_002399533.1 218691321 7139660 complement(3607922..3608314) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9298646; hypothetical protein 3608314 ygiW 7139660 ygiW Escherichia coli ED1a hypothetical protein YP_002399533.1 3607922 R 585397 CDS YP_002399534.1 218691322 7139661 3608466..3609125 1 NC_011745.1 response regulator in two-component regulatory system with QseC; regulates FlhCD which is the master regulator for flagella and motility genes; DNA-binding transcriptional regulator QseB 3609125 qseB 7139661 qseB Escherichia coli ED1a DNA-binding transcriptional regulator QseB YP_002399534.1 3608466 D 585397 CDS YP_002399535.1 218691323 7141242 3609122..3610471 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21927389; Product type r : regulator; sensor protein QseC 3610471 qseC 7141242 qseC Escherichia coli ED1a sensor protein QseC YP_002399535.1 3609122 D 585397 CDS YP_002399536.1 218691324 7139662 complement(3610855..3611592) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3611592 7139662 ECED1_3685 Escherichia coli ED1a hypothetical protein YP_002399536.1 3610855 R 585397 CDS YP_002399537.1 218691325 7141786 complement(3611568..3612047) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3612047 7141786 ECED1_3686 Escherichia coli ED1a hypothetical protein YP_002399537.1 3611568 R 585397 CDS YP_002399538.1 218691326 7141787 3612297..3612878 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96004656, 96217538; Product type c : carrier; NADPH quinone reductase 3612878 mdaB 7141787 mdaB Escherichia coli ED1a NADPH quinone reductase YP_002399538.1 3612297 D 585397 CDS YP_002399539.1 218691327 7142218 3612909..3613223 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10493123, 9298646, 9600841, 9868784; Product type e : enzyme; quinol monooxygenase 3613223 ygiN 7142218 ygiN Escherichia coli ED1a quinol monooxygenase YP_002399539.1 3612909 D 585397 CDS YP_002399540.1 218691328 7139656 complement(3613268..3614155) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative bifunctional protein: transcriptional regulator and sugar phosphate isomerase 3614155 7139656 ECED1_3689 Escherichia coli ED1a putative bifunctional protein: transcriptional regulator and sugar phosphate isomerase YP_002399540.1 3613268 R 585397 CDS YP_002399541.1 218691329 7140486 complement(3614152..3615162) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative iron compound-binding protein of ABC transporter family 3615162 7140486 ECED1_3690 Escherichia coli ED1a putative iron compound-binding protein of ABC transporter family YP_002399541.1 3614152 R 585397 CDS YP_002399542.1 218691330 7142277 complement(3615110..3616159) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative iron compound permease of ABC transporter family 3616159 7142277 ECED1_3691 Escherichia coli ED1a putative iron compound permease of ABC transporter family YP_002399542.1 3615110 R 585397 CDS YP_002399543.1 218691331 7142278 complement(3616156..3617139) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative iron compound permease of ABC transporter family 3617139 7142278 ECED1_3692 Escherichia coli ED1a putative iron compound permease of ABC transporter family YP_002399543.1 3616156 R 585397 CDS YP_002399544.1 218691332 7142281 3618319..3620460 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative iron compound receptor 3620460 7142281 ECED1_3695 Escherichia coli ED1a putative iron compound receptor YP_002399544.1 3618319 D 585397 CDS YP_002399545.1 218691333 7142282 complement(3620524..3622416) 1 NC_011745.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 3622416 parE 7142282 parE Escherichia coli ED1a DNA topoisomerase IV subunit B YP_002399545.1 3620524 R 585397 CDS YP_002399546.1 218691334 7144045 complement(3622445..3623026) 1 NC_011745.1 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase YqiA 3623026 yqiA 7144045 yqiA Escherichia coli ED1a esterase YqiA YP_002399546.1 3622445 R 585397 CDS YP_002399547.1 218691335 7143209 complement(3623026..3623850) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96411758; Product type e : enzyme; cyclic 3',5'-adenosine monophosphate phosphodiesterase 3623850 cpdA 7143209 cpdA Escherichia coli ED1a cyclic 3',5'-adenosine monophosphate phosphodiesterase YP_002399547.1 3623026 R 585397 CDS YP_002399548.1 218691336 7142041 complement(3623875..3624297) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 3624297 yqiB 7142041 yqiB Escherichia coli ED1a hypothetical protein YP_002399548.1 3623875 R 585397 CDS YP_002399549.1 218691337 7143210 complement(3624298..3624927) 1 NC_011745.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose pyrophosphatase NudF 3624927 nudF 7143210 nudF Escherichia coli ED1a ADP-ribose pyrophosphatase NudF YP_002399549.1 3624298 R 585397 CDS YP_002399550.1 218691338 7139941 3625132..3626613 1 NC_011745.1 trimeric outer membrane protein involved in efflux of hydrophobic/amphipathic molecules; functions with a number of efflux systems in the inner membrane to transport molecules out of the cell; outer membrane channel protein 3626613 tolC 7139941 tolC Escherichia coli ED1a outer membrane channel protein YP_002399550.1 3625132 D 585397 CDS YP_002399551.1 218691339 7141568 3626857..3627432 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3627432 ygiB 7141568 ygiB Escherichia coli ED1a hypothetical protein YP_002399551.1 3626857 D 585397 CDS YP_002399552.1 218691340 7139650 3627438..3628598 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 3628598 ygiC 7139650 ygiC Escherichia coli ED1a hypothetical protein YP_002399552.1 3627438 D 585397 CDS YP_002399553.1 218691341 7139651 3629083..3630879 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8887346, 11534764; Product type e : enzyme; arylsulfate sulfotransferase 3630879 assT 7139651 assT Escherichia coli ED1a arylsulfate sulfotransferase YP_002399553.1 3629083 D 585397 CDS YP_002399554.1 218691342 7142653 3630897..3631565 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8887346, 10600454; Product type e : enzyme; Thiol:disulfide interchange protein dsbA 3631565 dsbA 7142653 dsbA Escherichia coli ED1a Thiol:disulfide interchange protein dsbA YP_002399554.1 3630897 D 585397 CDS YP_002399555.1 218691343 7140520 3631580..3632251 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10600454; Product type pe : putative enzyme; putative disulfide oxidoreductase 3632251 7140520 ECED1_3706 Escherichia coli ED1a putative disulfide oxidoreductase YP_002399555.1 3631580 D 585397 CDS YP_002399556.1 218691344 7142283 complement(3632297..3633112) 1 NC_011745.1 seems to be involved in biofilm formation; in asymptomatic bacteriuria E. coli strains 83972 and VR50, the ygiD gene is upregulated during biofilm formation in urine; hypothetical protein 3633112 zupT 7142283 zupT Escherichia coli ED1a hypothetical protein YP_002399556.1 3632297 R 585397 CDS YP_002399557.1 218691345 7143198 3633228..3634001 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11790762, 1314093; Product type t : transporter; zinc transporter ZupT 3634001 ygiE 7143198 ygiE Escherichia coli ED1a zinc transporter ZupT YP_002399557.1 3633228 D 585397 CDS YP_002399558.1 218691346 7139652 complement(3634063..3634248) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3634248 7139652 ECED1_3709 Escherichia coli ED1a hypothetical protein YP_002399558.1 3634063 R 585397 CDS YP_002399559.1 218691347 7142284 3634804..3635367 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial protein 3635367 ygiL 7142284 ygiL Escherichia coli ED1a putative fimbrial protein YP_002399559.1 3634804 D 585397 CDS YP_002399560.1 218691348 7139655 3635454..3637976 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative outer membrane usher protein 3637976 yqiG 7139655 yqiG Escherichia coli ED1a putative outer membrane usher protein YP_002399560.1 3635454 D 585397 CDS YP_002399561.1 218691349 7143212 3637983..3638732 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative periplasmic pilin chaperone 3638732 yqiH 7143212 yqiH Escherichia coli ED1a putative periplasmic pilin chaperone YP_002399561.1 3637983 D 585397 CDS YP_002399562.1 218691350 7143213 3638729..3639778 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial adhesin 3639778 yqiI 7143213 yqiI Escherichia coli ED1a putative fimbrial adhesin YP_002399562.1 3638729 D 585397 CDS YP_002399563.1 218691351 7143214 complement(3639832..3640485) 1 NC_011745.1 DHBP synthase; functions during riboflavin biosynthesis; 3,4-dihydroxy-2-butanone 4-phosphate synthase 3640485 ribB 7143214 ribB Escherichia coli ED1a 3,4-dihydroxy-2-butanone 4-phosphate synthase YP_002399563.1 3639832 R 585397 CDS YP_002399564.1 218691352 7140765 3640799..3641158 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3641158 yqiC 7140765 yqiC Escherichia coli ED1a hypothetical protein YP_002399564.1 3640799 D 585397 CDS YP_002399565.1 218691353 7143211 complement(3641193..3641393) 1 NC_011745.1 Involved in glycogen synthesis. May be involved in glycogen priming; glycogen synthesis protein GlgS 3641393 glgS 7143211 glgS Escherichia coli ED1a glycogen synthesis protein GlgS YP_002399565.1 3641193 R 585397 CDS YP_002399566.1 218691354 7143189 3641663..3642292 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3642292 yqiJ 7143189 yqiJ Escherichia coli ED1a hypothetical protein YP_002399566.1 3641663 D 585397 CDS YP_002399567.1 218691355 7143215 3642319..3643980 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3643980 yqiK 7143215 yqiK Escherichia coli ED1a hypothetical protein YP_002399567.1 3642319 D 585397 CDS YP_002399568.1 218691356 7141350 complement(3644399..3645832) 1 NC_011745.1 catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose; bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase 3645832 rfaE 7141350 rfaE Escherichia coli ED1a bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase YP_002399568.1 3644399 R 585397 CDS YP_002399569.1 218691357 7141591 complement(3645880..3648720) 1 NC_011745.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase 3648720 glnE 7141591 glnE Escherichia coli ED1a bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase YP_002399569.1 3645880 R 585397 CDS YP_002399570.1 218691358 7142956 complement(3648743..3650044) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8412694; Product type pe : putative enzyme; putative adenylate cyclase 3650044 ygiF 7142956 ygiF Escherichia coli ED1a putative adenylate cyclase YP_002399570.1 3648743 R 585397 CDS YP_002399571.1 218691359 7139653 complement(3650061..3650267) 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 3650267 7139653 ECED1_3723 Escherichia coli ED1a hypothetical protein YP_002399571.1 3650061 R 585397 CDS YP_002399572.1 218691360 7142285 3650286..3650906 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11274153; Product type pr : putative regulator; putative signal transduction protein 3650906 htrG 7142285 htrG Escherichia coli ED1a putative signal transduction protein YP_002399572.1 3650286 D 585397 CDS YP_002399573.1 218691361 7140176 3650970..3652208 1 NC_011745.1 catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases; multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase 3652208 cca 7140176 cca Escherichia coli ED1a multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase YP_002399573.1 3650970 D 585397 CDS YP_002399574.1 218691362 7139312 complement(3652390..3653211) 1 NC_011745.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; undecaprenyl pyrophosphate phosphatase 3653211 bacA 7139312 bacA Escherichia coli ED1a undecaprenyl pyrophosphate phosphatase YP_002399574.1 3652390 R 585397 CDS YP_002399575.1 218691363 7140426 complement(3653302..3653670) 1 NC_011745.1 catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin; bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase 3653670 folB 7140426 folB Escherichia coli ED1a bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase YP_002399575.1 3653302 R 585397 CDS YP_002399576.1 218691364 7142156 3653775..3654392 1 NC_011745.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; putative glycerol-3-phosphate acyltransferase PlsY 3654392 plsY 7142156 plsY Escherichia coli ED1a putative glycerol-3-phosphate acyltransferase PlsY YP_002399576.1 3653775 D 585397 CDS YP_002399577.1 218691365 7139072 complement(3654405..3655337) 1 NC_011745.1 activates expression of genes required for L-tartrate-dependent anaerobic growth on glycerol; transcriptional activator TtdR 3655337 ygiP 7139072 ygiP Escherichia coli ED1a transcriptional activator TtdR YP_002399577.1 3654405 R 585397 CDS YP_002399578.1 218691366 7139657 3655544..3656455 1 NC_011745.1 Involved in the tartrate degradation pathway; tartrate dehydratase subunit alpha 3656455 ttdA 7139657 ttdA Escherichia coli ED1a tartrate dehydratase subunit alpha YP_002399578.1 3655544 D 585397 CDS YP_002399579.1 218691367 7140839 3656452..3657057 1 NC_011745.1 Involved in the tartrate degradation pathway; L(+)-tartrate dehydratase subunit beta 3657057 ttdB 7140839 ttdB Escherichia coli ED1a L(+)-tartrate dehydratase subunit beta YP_002399579.1 3656452 D 585397 CDS YP_002399580.1 218691368 7140840 3657105..3658568 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative tartrate:succinate antiporter 3658568 ygjE 7140840 ygjE Escherichia coli ED1a putative tartrate:succinate antiporter YP_002399580.1 3657105 D 585397 CDS YP_002399581.1 218691369 7139663 complement(3658611..3659624) 1 NC_011745.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; putative DNA-binding/iron metalloprotein/AP endonuclease 3659624 gcp 7139663 gcp Escherichia coli ED1a putative DNA-binding/iron metalloprotein/AP endonuclease YP_002399581.1 3658611 R 585397 CDS YP_002399582.1 218691370 7143166 3659862..3660077 1 NC_011745.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 3660077 rpsU 7143166 rpsU Escherichia coli ED1a 30S ribosomal protein S21 YP_002399582.1 3659862 D 585397 CDS YP_002399583.1 218691371 7140104 3660188..3661933 1 NC_011745.1 synthesizes RNA primers at the replication forks; DNA primase 3661933 dnaG 7140104 dnaG Escherichia coli ED1a DNA primase YP_002399583.1 3660188 D 585397 CDS YP_002399584.1 218691372 7140506 3662128..3663969 1 NC_011745.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria; RNA polymerase sigma factor RpoD 3663969 rpoD 7140506 rpoD Escherichia coli ED1a RNA polymerase sigma factor RpoD YP_002399584.1 3662128 D 585397 CDS YP_002399585.1 218691373 7141487 complement(3664047..3664553) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20412902, 99453007, 6269063, 7567469, 8878487, 9489705; Product type e : enzyme; G/U mismatch-specific DNA glycosylase 3664553 ygjF 7141487 ygjF Escherichia coli ED1a G/U mismatch-specific DNA glycosylase YP_002399585.1 3664047 R 585397 CDS YP_002399586.1 218691374 7140578 complement(3664807..3665571) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative siderophore interacting protein 3665571 yqjH 7140578 yqjH Escherichia coli ED1a putative siderophore interacting protein YP_002399586.1 3664807 R 585397 CDS YP_002399587.1 218691375 7143224 3665859..3666482 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 3666482 yqjI 7143224 yqjI Escherichia coli ED1a putative transcriptional regulator YP_002399587.1 3665859 D 585397 CDS YP_002399588.1 218691376 7143225 complement(3666589..3668109) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20015410, 9380671, 9643537, 9190831; Product type r : regulator; fused signal transducer for aerotaxis sensory component ; methyl accepting chemotaxis component 3668109 aer 7143225 aer Escherichia coli ED1a fused signal transducer for aerotaxis sensory component ; methyl accepting chemotaxis component YP_002399588.1 3666589 R 585397 CDS YP_002399589.1 218691377 7143668 3668500..3669906 1 NC_011745.1 catalyzes the formation of 4-aminobutyraldehyde from putrescine and 2-oxoglutarate; putrescine--2-oxoglutarate aminotransferase 3669906 ygjG 7143668 ygjG Escherichia coli ED1a putrescine--2-oxoglutarate aminotransferase YP_002399589.1 3668500 D 585397 CDS YP_002399590.1 218691378 7139665 complement(3669948..3670280) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11101501; hypothetical protein 3670280 ygjH 7139665 ygjH Escherichia coli ED1a hypothetical protein YP_002399590.1 3669948 R 585397 CDS YP_002399591.1 218691379 7139666 3670499..3671482 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89128452, 2515108, 3939708; Product type r : regulator; DNA-binding transcriptional repressor EbgR 3671482 ebgR 7139666 ebgR Escherichia coli ED1a DNA-binding transcriptional repressor EbgR YP_002399591.1 3670499 D 585397 CDS YP_002399592.1 218691380 7139766 3671666..3674758 1 NC_011745.1 in Escherichia coli this is the second beta-galactosidase system; cryptic beta-D-galactosidase subunit alpha 3674758 ebgA 7139766 ebgA Escherichia coli ED1a cryptic beta-D-galactosidase subunit alpha YP_002399592.1 3671666 D 585397 CDS YP_002399593.1 218691381 7139764 3674755..3675204 1 NC_011745.1 in Escherichia coli this is the second beta-galactosidase system; cryptic beta-D-galactosidase subunit beta 3675204 ebgC 7139764 ebgC Escherichia coli ED1a cryptic beta-D-galactosidase subunit beta YP_002399593.1 3674755 D 585397 CDS YP_002399594.1 218691382 7139765 3675267..3676700 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 3676700 ygjI 7139765 ygjI Escherichia coli ED1a putative transporter YP_002399594.1 3675267 D 585397 CDS YP_002399595.1 218691383 7139667 3676834..3677904 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3677904 ygjJ 7139667 ygjJ Escherichia coli ED1a hypothetical protein YP_002399595.1 3676834 D 585397 CDS YP_002399596.1 218691384 7139668 3677921..3680272 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15213393; Product type pe : putative enzyme; putative glycosyl hydrolase 3680272 ygjK 7139668 ygjK Escherichia coli ED1a putative glycosyl hydrolase YP_002399596.1 3677921 D 585397 CDS YP_002399597.1 218691385 7139669 3680498..3682516 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12840019, 89380266; Product type e : enzyme; 2,4-dienoyl-CoA reductase, NADH and FMN-linked 3682516 fadH 7139669 fadH Escherichia coli ED1a 2,4-dienoyl-CoA reductase, NADH and FMN-linked YP_002399597.1 3680498 D 585397 CDS YP_002399598.1 218691386 7144128 complement(3682561..3682977) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3682977 ygjM 7144128 ygjM Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002399598.1 3682561 R 585397 CDS YP_002399599.1 218691387 7139670 complement(3683248..3684384) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative methyltransferase small domain 3684384 ygjO 7139670 ygjO Escherichia coli ED1a putative methyltransferase small domain YP_002399599.1 3683248 R 585397 CDS YP_002399600.1 218691388 7139671 3684469..3684972 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative metal dependent hydrolase 3684972 ygjP 7139671 ygjP Escherichia coli ED1a putative metal dependent hydrolase YP_002399600.1 3684469 D 585397 CDS YP_002399601.1 218691389 7139672 3685049..3685741 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative thioredoxin-like 3685741 ygjQ 7139672 ygjQ Escherichia coli ED1a putative thioredoxin-like YP_002399601.1 3685049 D 585397 CDS YP_002399602.1 218691390 7139673 3685802..3686806 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative NAD(P)-binding dehydrogenase 3686806 ygjR 7139673 ygjR Escherichia coli ED1a putative NAD(P)-binding dehydrogenase YP_002399602.1 3685802 D 585397 CDS YP_002399603.1 218691391 7143837 3687089..3688054 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12107143, 2108134; Product type pm : putative membrane component; hypothetical protein 3688054 alx 7143837 alx Escherichia coli ED1a hypothetical protein YP_002399603.1 3687089 D 585397 CDS YP_002399604.1 218691392 7143701 3688378..3689622 1 NC_011745.1 involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 3689622 sstT 7143701 sstT Escherichia coli ED1a serine/threonine transporter SstT YP_002399604.1 3688378 D 585397 CDS YP_002399605.1 218691393 7143855 complement(3689626..3690177) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3690177 ygjV 7143855 ygjV Escherichia coli ED1a hypothetical protein YP_002399605.1 3689626 R 585397 CDS YP_002399606.1 218691394 7139467 complement(3690260..3691747) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 4570160, 83114543, 3038546; Product type e : enzyme; altronate hydrolase 3691747 uxaA 7139467 uxaA Escherichia coli ED1a altronate hydrolase YP_002399606.1 3690260 R 585397 CDS YP_002399607.1 218691395 7139155 complement(3691762..3693174) 1 NC_011745.1 catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism; glucuronate isomerase 3693174 uxaC 7139155 uxaC Escherichia coli ED1a glucuronate isomerase YP_002399607.1 3691762 R 585397 CDS YP_002399608.1 218691396 7139836 3695085..3695861 1 NC_011745.1 regulates the exuT, uxaCA and uxuRAB operons which encode genes involved in hexuronate utilization.; DNA-binding transcriptional repressor ExuR 3695861 exuR 7139836 exuR Escherichia coli ED1a DNA-binding transcriptional repressor ExuR YP_002399608.1 3695085 D 585397 CDS YP_002399609.1 218691397 7139834 3696206..3696868 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3696868 yqjA 7139834 yqjA Escherichia coli ED1a hypothetical protein YP_002399609.1 3696206 D 585397 CDS YP_002399610.1 218691398 7143217 3696872..3697255 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11274153; hypothetical protein 3697255 yqjB 7143217 yqjB Escherichia coli ED1a hypothetical protein YP_002399610.1 3696872 D 585397 CDS YP_002399611.1 218691399 7143218 3697402..3697770 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3697770 yqjC 7143218 yqjC Escherichia coli ED1a hypothetical protein YP_002399611.1 3697402 D 585397 CDS YP_002399612.1 218691400 7143219 3697808..3698113 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3698113 yqjD 7143219 yqjD Escherichia coli ED1a hypothetical protein YP_002399612.1 3697808 D 585397 CDS YP_002399613.1 218691401 7143220 3698116..3698520 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3698520 yqjE 7143220 yqjE Escherichia coli ED1a hypothetical protein YP_002399613.1 3698116 D 585397 CDS YP_002399614.1 218691402 7143221 3698510..3698809 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3698809 yqjK 7143221 yqjK Escherichia coli ED1a hypothetical protein YP_002399614.1 3698510 D 585397 CDS YP_002399615.1 218691403 7143226 3698996..3699388 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative quinol oxidase subunit 3699388 yqjF 7143226 yqjF Escherichia coli ED1a putative quinol oxidase subunit YP_002399615.1 3698996 D 585397 CDS YP_002399616.1 218691404 7143222 3699458..3700444 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8478329; Product type e : enzyme; S-transferase 3700444 yqjG 7143222 yqjG Escherichia coli ED1a S-transferase YP_002399616.1 3699458 D 585397 CDS YP_002399617.1 218691405 7143223 3700706..3701095 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3701095 yhaH 7143223 yhaH Escherichia coli ED1a hypothetical protein YP_002399617.1 3700706 D 585397 CDS YP_002399618.1 218691406 7139468 complement(3701129..3702025) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3702025 yhaJ 7139468 yhaJ Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002399618.1 3701129 R 585397 CDS YP_002399619.1 218691407 7139469 3702130..3702831 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative pirin-related protein 3702831 yhaK 7139469 yhaK Escherichia coli ED1a putative pirin-related protein YP_002399619.1 3702130 D 585397 CDS YP_002399620.1 218691408 7139470 3702854..3703018 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3703018 yhaL 7139470 yhaL Escherichia coli ED1a hypothetical protein YP_002399620.1 3702854 D 585397 CDS YP_002399621.1 218691409 7139471 complement(3703152..3704462) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3704462 yhaM 7139471 yhaM Escherichia coli ED1a hypothetical protein YP_002399621.1 3703152 R 585397 CDS YP_002399622.1 218691410 7139472 complement(3704490..3705758) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 3705758 yhaO 7139472 yhaO Escherichia coli ED1a putative transporter YP_002399622.1 3704490 R 585397 CDS YP_002399623.1 218691411 7139473 complement(3706096..3707460) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98143432, 9484901; Product type e : enzyme; L-serine dehydratase 3 3707460 tdcG 7139473 tdcG Escherichia coli ED1a L-serine dehydratase 3 YP_002399623.1 3706096 R 585397 CDS YP_002399624.1 218691412 7141528 complement(3707532..3707921) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12777779, 9484901; Product type e : enzyme; hypothetical protein 3707921 tdcF 7141528 tdcF Escherichia coli ED1a hypothetical protein YP_002399624.1 3707532 R 585397 CDS YP_002399625.1 218691413 7141527 complement(3707935..3710229) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98143432, 9484901; Product type e : enzyme; pyruvate formate-lyase 4/2-ketobutyrate formate-lyase 3710229 tdcE 7141527 tdcE Escherichia coli ED1a pyruvate formate-lyase 4/2-ketobutyrate formate-lyase YP_002399625.1 3707935 R 585397 CDS YP_002399626.1 218691414 7141526 complement(3710263..3711483) 1 NC_011745.1 catalyzes the formation of propanoyl phosphate from propanoate and ATP; TdcD also has acetate kinase activities and functions in anaerobic threonine catabolism; propionate/acetate kinase 3711483 tdcD 7141526 tdcD Escherichia coli ED1a propionate/acetate kinase YP_002399626.1 3710263 R 585397 CDS YP_002399627.1 218691415 7141525 complement(3711497..3712828) 1 NC_011745.1 involved in the import of threonine and serine in combination with the import of a proton; threonine/serine transporter TdcC 3712828 tdcC 7141525 tdcC Escherichia coli ED1a threonine/serine transporter TdcC YP_002399627.1 3711497 R 585397 CDS YP_002399628.1 218691416 7141524 complement(3712850..3713839) 1 NC_011745.1 catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic; threonine dehydratase 3713839 tdcB 7141524 tdcB Escherichia coli ED1a threonine dehydratase YP_002399628.1 3712850 R 585397 CDS YP_002399629.1 218691417 7141523 complement(3713938..3714876) 1 NC_011745.1 regulates the tdcABCDEFG operon which is involved in amino acid degradation; DNA-binding transcriptional activator TdcA 3714876 tdcA 7141523 tdcA Escherichia coli ED1a DNA-binding transcriptional activator TdcA YP_002399629.1 3713938 R 585397 CDS YP_002399630.1 218691418 7141522 3715053..3715409 1 NC_011745.1 participates in controlling the expression of several structural genes for the enzyme threonine dehydratase; TdcR activates the tdcABCDEFG operon; DNA-binding transcriptional activator TdcR 3715409 tdcR 7141522 tdcR Escherichia coli ED1a DNA-binding transcriptional activator TdcR YP_002399630.1 3715053 D 585397 CDS YP_002399631.1 218691419 7141441 complement(3716375..3717601) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20225875, 69151449, 9772162; Product type e : enzyme; glycerate kinase I 3717601 garK 7141441 garK Escherichia coli ED1a glycerate kinase I YP_002399631.1 3716375 R 585397 CDS YP_002399632.1 218691420 7143160 complement(3717617..3718507) 1 NC_011745.1 catalyzes the reduction of tartronate semialdehyde to glycerate; tartronate semialdehyde reductase 3718507 garR 7143160 garR Escherichia coli ED1a tartronate semialdehyde reductase YP_002399632.1 3717617 R 585397 CDS YP_002399633.1 218691421 7143163 complement(3718537..3719304) 1 NC_011745.1 cleaves 5-dehydro-4-deoxy-glucarate and 2-dehydro-3-deoxy-D-glucarate; alpha-dehydro-beta-deoxy-D-glucarate aldolase 3719304 garL 7143163 garL Escherichia coli ED1a alpha-dehydro-beta-deoxy-D-glucarate aldolase YP_002399633.1 3718537 R 585397 CDS YP_002399634.1 218691422 7143162 3721049..3722620 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20225875, 66096392, 81027430, 9772162, 10762278, 2407727; Product type e : enzyme; (D)-galactarate dehydrogenase 3722620 garD 7143162 garD Escherichia coli ED1a (D)-galactarate dehydrogenase YP_002399634.1 3721049 D 585397 CDS YP_002399635.1 218691423 7143159 3722769..3723104 1 NC_011745.1 SohA; PrlF; involved in protein secretion; when overproduced or mutated, it induces growth defect and increased export of a reporter protein; a PrlF mutation induces the activity of the Lon protease, and a Lon-deficient strain suppresses the phenotype conferred by the PrlF mutation; putative regulator PrlF 3723104 sohA 7143159 sohA Escherichia coli ED1a putative regulator PrlF YP_002399635.1 3722769 D 585397 CDS YP_002399636.1 218691424 7143817 3723104..3723568 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3723568 yhaV 7143817 yhaV Escherichia coli ED1a hypothetical protein YP_002399636.1 3723104 D 585397 CDS YP_002399637.1 218691425 7139474 complement(3723623..3724432) 1 NC_011745.1 transcriptional repressor for the agaZVWA and agaSYBCDI operons; DNA-binding transcriptional regulator AgaR 3724432 agaR 7139474 agaR Escherichia coli ED1a DNA-binding transcriptional regulator AgaR YP_002399637.1 3723623 R 585397 CDS YP_002399638.1 218691426 7143676 3724681..3725961 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11976750, 20392444, 10931310, 8932697; Product type e : enzyme; tagatose 6-phosphate aldolase 1, kbaZ subunit 3725961 kbaZ 7143676 kbaZ Escherichia coli ED1a tagatose 6-phosphate aldolase 1, kbaZ subunit YP_002399638.1 3724681 D 585397 CDS YP_002399639.1 218691427 7142487 3725984..3726457 1 NC_011745.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake;involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIB 3726457 agaV 7142487 agaV Escherichia coli ED1a PTS system N-acetylgalactosamine-specific transporter subunit IIB YP_002399639.1 3725984 D 585397 CDS YP_002399640.1 218691428 7143678 3726468..3727247 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative enzyme IIC component of PTS 3727247 7143678 ECED1_3796 Escherichia coli ED1a putative enzyme IIC component of PTS YP_002399640.1 3726468 D 585397 CDS YP_002399641.1 218691429 7142286 3727231..3728115 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative hexose/hexosamine family PTS permease IID component 3728115 7142286 ECED1_3797 Escherichia coli ED1a putative hexose/hexosamine family PTS permease IID component YP_002399641.1 3727231 D 585397 CDS YP_002399642.1 218691430 7142287 3728133..3728567 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphotransferase system enzyme subunit (N-acetyl-galactosamine / galactosamine PTS system enzyme IIA component) 3728567 7142287 ECED1_3798 Escherichia coli ED1a putative phosphotransferase system enzyme subunit (N-acetyl-galactosamine / galactosamine PTS system enzyme IIA component) YP_002399642.1 3728133 D 585397 CDS YP_002399643.1 218691431 7142288 3728543..3729697 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; N-acetylglucosamine-6-phosphate deacetylase 3729697 agaA 7142288 agaA Escherichia coli ED1a N-acetylglucosamine-6-phosphate deacetylase YP_002399643.1 3728543 D 585397 CDS YP_002399644.1 218691432 7143671 3730048..3731202 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689210, 9697096, 14731281, 8932697; Product type e : enzyme; tagatose-6-phosphate ketose/aldose isomerase 3731202 agaS 7143671 agaS Escherichia coli ED1a tagatose-6-phosphate ketose/aldose isomerase YP_002399644.1 3730048 D 585397 CDS YP_002399645.1 218691433 7143677 3731215..3732075 1 NC_011745.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway; tagatose-bisphosphate aldolase 3732075 kbaY 7143677 kbaY Escherichia coli ED1a tagatose-bisphosphate aldolase YP_002399645.1 3731215 D 585397 CDS YP_002399646.1 218691434 7142486 3732242..3732718 1 NC_011745.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIB 3732718 agaB 7142486 agaB Escherichia coli ED1a PTS system N-acetylgalactosamine-specific transporter subunit IIB YP_002399646.1 3732242 D 585397 CDS YP_002399647.1 218691435 7143672 3732757..3733560 1 NC_011745.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane;protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIC 3733560 agaC 7143672 agaC Escherichia coli ED1a PTS system N-acetylgalactosamine-specific transporter subunit IIC YP_002399647.1 3732757 D 585397 CDS YP_002399648.1 218691436 7143673 3733550..3734341 1 NC_011745.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IID 3734341 agaD 7143673 agaD Escherichia coli ED1a PTS system N-acetylgalactosamine-specific transporter subunit IID YP_002399648.1 3733550 D 585397 CDS YP_002399649.1 218691437 7143674 3734342..3735109 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10931310; Product type e : enzyme; galactosamine-6-phosphate isomerase 3735109 agaI 7143674 agaI Escherichia coli ED1a galactosamine-6-phosphate isomerase YP_002399649.1 3734342 D 585397 CDS YP_002399650.1 218691438 7143675 complement(3735159..3736022) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative methyltransferase 3736022 yraL 7143675 yraL Escherichia coli ED1a putative methyltransferase YP_002399650.1 3735159 R 585397 CDS YP_002399651.1 218691439 7143227 3736087..3738123 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3738123 yraM 7143227 yraM Escherichia coli ED1a hypothetical protein YP_002399651.1 3736087 D 585397 CDS YP_002399652.1 218691440 7143228 3738081..3738476 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3738476 yraN 7143228 yraN Escherichia coli ED1a hypothetical protein YP_002399652.1 3738081 D 585397 CDS YP_002399653.1 218691441 7143229 3738496..3739086 1 NC_011745.1 Required for the timely initiation of chromosomal replication via direct interactions with the dnaA initiator protein; DnaA initiator-associating protein DiaA 3739086 yraO 7143229 yraO Escherichia coli ED1a DnaA initiator-associating protein DiaA YP_002399653.1 3738496 D 585397 CDS YP_002399654.1 218691442 7143230 3739096..3739671 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11274153; hypothetical protein 3739671 ecfH 7143230 ecfH Escherichia coli ED1a hypothetical protein YP_002399654.1 3739096 D 585397 CDS YP_002399655.1 218691443 7139767 complement(3739784..3740824) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative permease 3740824 yraQ 7139767 yraQ Escherichia coli ED1a putative permease YP_002399655.1 3739784 R 585397 CDS YP_002399656.1 218691444 7143231 complement(3740897..3741532) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative nucleoside-diphosphate-sugar epimerase 3741532 yraR 7143231 yraR Escherichia coli ED1a putative nucleoside-diphosphate-sugar epimerase YP_002399656.1 3740897 R 585397 CDS YP_002399657.1 218691445 7143232 3741660..3742178 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative intracellular protease 3742178 yhbO 7143232 yhbO Escherichia coli ED1a putative intracellular protease YP_002399657.1 3741660 D 585397 CDS YP_002399658.1 218691446 7139479 complement(3742158..3742601) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3742601 yhbP 7139479 yhbP Escherichia coli ED1a hypothetical protein YP_002399658.1 3742158 R 585397 CDS YP_002399659.1 218691447 7139480 3742652..3742954 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; GIY-YIG nuclease superfamily protein 3742954 yhbQ 7139480 yhbQ Escherichia coli ED1a GIY-YIG nuclease superfamily protein YP_002399659.1 3742652 D 585397 CDS YP_002399660.1 218691448 7139481 complement(3742941..3743444) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acyl-CoA N-acyltransferase domain-containing acyltransferase 3743444 yhbS 7139481 yhbS Escherichia coli ED1a putative acyl-CoA N-acyltransferase domain-containing acyltransferase YP_002399660.1 3742941 R 585397 CDS YP_002399661.1 218691449 7139482 complement(3743438..3743962) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative lipid carrier protein 3743962 yhbT 7139482 yhbT Escherichia coli ED1a putative lipid carrier protein YP_002399661.1 3743438 R 585397 CDS YP_002399662.1 218691450 7139483 3744171..3745166 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10206698; Product type e : enzyme; collagenase-like peptidase 3745166 yhbU 7139483 yhbU Escherichia coli ED1a collagenase-like peptidase YP_002399662.1 3744171 D 585397 CDS YP_002399663.1 218691451 7139484 3745175..3746053 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10206698; Product type e : enzyme; protease 3746053 yhbV 7139484 yhbV Escherichia coli ED1a protease YP_002399663.1 3745175 D 585397 CDS YP_002399664.1 218691452 7139485 3746134..3747141 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 3747141 yhbW 7139485 yhbW Escherichia coli ED1a hypothetical protein YP_002399664.1 3746134 D 585397 CDS YP_002399665.1 218691453 7139486 complement(3747259..3748503) 1 NC_011745.1 tryptophan transporter of high affinity; tryptophan permease 3748503 mtr 7139486 mtr Escherichia coli ED1a tryptophan permease YP_002399665.1 3747259 R 585397 CDS YP_002399666.1 218691454 7139041 complement(3748657..3750546) 1 NC_011745.1 participates in the assembly of the large subunit of the ribosome; plays a key role in optimal cell growth at low temperature and is required for normal cell division; ATP-dependent RNA helicase DeaD 3750546 deaD 7139041 deaD Escherichia coli ED1a ATP-dependent RNA helicase DeaD YP_002399666.1 3748657 R 585397 CDS YP_002399667.1 218691455 7143082 complement(3750726..3751610) 1 NC_011745.1 lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing; lipoprotein NlpI 3751610 nlpI 7143082 nlpI Escherichia coli ED1a lipoprotein NlpI YP_002399667.1 3750726 R 585397 CDS YP_002399668.1 218691456 7140402 complement(3751719..3753923) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87083499, 91198209, 99234021, 99340204, 2432069, 3005122, 6382163, 9008164, 9298646; Product type e : enzyme; polynucleotide phosphorylase/polyadenylase 3753923 pnp 7140402 pnp Escherichia coli ED1a polynucleotide phosphorylase/polyadenylase YP_002399668.1 3751719 R 585397 CDS YP_002399669.1 218691457 7143838 complement(3754101..3754370) 1 NC_011745.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 3754370 rpsO 7143838 rpsO Escherichia coli ED1a 30S ribosomal protein S15 YP_002399669.1 3754101 R 585397 CDS YP_002399670.1 218691458 7140098 complement(3754519..3755463) 1 NC_011745.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 3755463 truB 7140098 truB Escherichia coli ED1a tRNA pseudouridine synthase B YP_002399670.1 3754519 R 585397 CDS YP_002399671.1 218691459 7140828 complement(3755463..3755864) 1 NC_011745.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 3755864 rbfA 7140828 rbfA Escherichia coli ED1a ribosome-binding factor A YP_002399671.1 3755463 R 585397 CDS YP_002399672.1 218691460 7141254 complement(3756028..3758700) 1 NC_011745.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 3758700 infB 7141254 infB Escherichia coli ED1a translation initiation factor IF-2 YP_002399672.1 3756028 R 585397 CDS YP_002399673.1 218691461 7141110 complement(3758725..3760212) 1 NC_011745.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 3760212 nusA 7141110 nusA Escherichia coli ED1a transcription elongation factor NusA YP_002399673.1 3758725 R 585397 CDS YP_002399674.1 218691462 7139959 complement(3760240..3760692) 1 NC_011745.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 3760692 yhbC 7139959 yhbC Escherichia coli ED1a hypothetical protein YP_002399674.1 3760240 R 585397 CDS YP_002399675.1 218691463 7140611 3761323..3762666 1 NC_011745.1 catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis; argininosuccinate synthase 3762666 argG 7140611 argG Escherichia coli ED1a argininosuccinate synthase YP_002399675.1 3761323 D 585397 CDS YP_002399676.1 218691464 7142614 complement(3762674..3764299) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase, inner membrane 3764299 yhbX 7142614 yhbX Escherichia coli ED1a putative hydrolase, inner membrane YP_002399676.1 3762674 R 585397 CDS YP_002399677.1 218691465 7140610 complement(3764857..3765189) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20194819, 21125563, 9020118, 94074540, 9564033, 9644254, 9829959, 99298179, 7556084, 8034620, 8045257, 8244950, 8253068; Product type t : transporter; preprotein translocase subunit SecG 3765189 secG 7140610 secG Escherichia coli ED1a preprotein translocase subunit SecG YP_002399677.1 3764857 R 585397 CDS YP_002399678.1 218691466 7141390 complement(3765417..3766754) 1 NC_011745.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 3766754 glmM 7141390 glmM Escherichia coli ED1a phosphoglucosamine mutase YP_002399678.1 3765417 R 585397 CDS YP_002399679.1 218691467 7143192 complement(3766747..3767595) 1 NC_011745.1 catalyzes the formation of dihydropteroate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate; dihydropteroate synthase 3767595 folP 7143192 folP Escherichia coli ED1a dihydropteroate synthase YP_002399679.1 3766747 R 585397 CDS YP_002399680.1 218691468 7142162 complement(3767685..3769619) 1 NC_011745.1 inner membrane metalloprotease; may be involved in degradation of aberrant cytoplasmic and membrane proteins; ATP-dependent metalloprotease 3769619 hflB 7142162 hflB Escherichia coli ED1a ATP-dependent metalloprotease YP_002399680.1 3767685 R 585397 CDS YP_002399681.1 218691469 7142191 complement(3769719..3770348) 1 NC_011745.1 Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit; 23S rRNA methyltransferase J 3770348 rrmJ 7142191 rrmJ Escherichia coli ED1a 23S rRNA methyltransferase J YP_002399681.1 3769719 R 585397 CDS YP_002399682.1 218691470 7140107 3770474..3770767 1 NC_011745.1 RNA binding protein found associated to pre-50S subunit of the ribosome; putative role in ribosome assembly; necessary for optimal growth but not cell viability; RNA-binding protein YhbY 3770767 yhbY 7140107 yhbY Escherichia coli ED1a RNA-binding protein YhbY YP_002399682.1 3770474 D 585397 CDS YP_002399683.1 218691471 7139488 complement(3770923..3771399) 1 NC_011745.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 3771399 greA 7139488 greA Escherichia coli ED1a transcription elongation factor GreA YP_002399683.1 3770923 R 585397 CDS YP_002399684.1 218691472 7143019 3771647..3773080 1 NC_011745.1 penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase/endopeptidase 3773080 dacB 7143019 dacB Escherichia coli ED1a D-alanyl-D-alanine carboxypeptidase/endopeptidase YP_002399684.1 3771647 D 585397 CDS YP_002399685.1 218691473 7143053 complement(3773121..3774293) 1 NC_011745.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 3774293 obgE 7143053 obgE Escherichia coli ED1a GTPase ObgE YP_002399685.1 3773121 R 585397 CDS YP_002399686.1 218691474 7139964 complement(3774309..3775274) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3775274 yhbE 7139964 yhbE Escherichia coli ED1a hypothetical protein YP_002399686.1 3774309 R 585397 CDS YP_002399687.1 218691475 7139476 complement(3775401..3775658) 1 NC_011745.1 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 3775658 rpmA 7139476 rpmA Escherichia coli ED1a 50S ribosomal protein L27 YP_002399687.1 3775401 R 585397 CDS YP_002399688.1 218691476 7141475 complement(3775679..3775990) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91088242, 94146411, 10094780, 387076, 8312607; Product type s : structure; 50S ribosomal protein L21 3775990 rplU 7141475 rplU Escherichia coli ED1a 50S ribosomal protein L21 YP_002399688.1 3775679 R 585397 CDS YP_002399689.1 218691477 7141470 3776249..3777220 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94311902, 97284515, 2670911, 8037730, 8312607; Product type e : enzyme; octaprenyl diphosphate synthase 3777220 ispB 7141470 ispB Escherichia coli ED1a octaprenyl diphosphate synthase YP_002399689.1 3776249 D 585397 CDS YP_002399690.1 218691478 7142463 3777454..3777732 1 NC_011745.1 activator of maltose metabolism genes; DNA-binding transcriptional regulator Nlp 3777732 sfsB 7142463 sfsB Escherichia coli ED1a DNA-binding transcriptional regulator Nlp YP_002399690.1 3777454 D 585397 CDS YP_002399691.1 218691479 7141405 complement(3777780..3779039) 1 NC_011745.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 3779039 murA 7141405 murA Escherichia coli ED1a UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_002399691.1 3777780 R 585397 CDS YP_002399692.1 218691480 7139045 complement(3779094..3779348) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3779348 yrbA 7139045 yrbA Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002399692.1 3779094 R 585397 CDS YP_002399693.1 218691481 7143233 complement(3779508..3779801) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3779801 yrbB 7143233 yrbB Escherichia coli ED1a hypothetical protein YP_002399693.1 3779508 R 585397 CDS YP_002399694.1 218691482 7143234 complement(3779801..3780436) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9658016; Product type t : transporter; toluene ABC transporter membrane protein 3780436 yrbC 7143234 yrbC Escherichia coli ED1a toluene ABC transporter membrane protein YP_002399694.1 3779801 R 585397 CDS YP_002399695.1 218691483 7143235 complement(3780455..3781006) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9658016; Product type t : transporter; toluene ABC transporter membrane protein 3781006 yrbD 7143235 yrbD Escherichia coli ED1a toluene ABC transporter membrane protein YP_002399695.1 3780455 R 585397 CDS YP_002399696.1 218691484 7143236 complement(3781011..3781793) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9658016; Product type t : transporter; toluene ABC transporter membrane protein 3781793 yrbE 7143236 yrbE Escherichia coli ED1a toluene ABC transporter membrane protein YP_002399696.1 3781011 R 585397 CDS YP_002399697.1 218691485 7143237 complement(3781801..3782610) 1 NC_011745.1 ATP-binding subunit of a putative ABC toluene efflux transporter; putative ABC transporter ATP-binding protein YrbF 3782610 yrbF 7143237 yrbF Escherichia coli ED1a putative ABC transporter ATP-binding protein YrbF YP_002399697.1 3781801 R 585397 CDS YP_002399698.1 218691486 7143238 3782820..3783797 1 NC_011745.1 YrbG; inner membrane protein involved in cell envelope integrity; putative sodium ion/calcium ion exchanger; in E. coli it is non essential for cell viability; member of the YRBG family of cation/Ca2+ exchangers; putative calcium/sodium:proton antiporter 3783797 yrbG 7143238 yrbG Escherichia coli ED1a putative calcium/sodium:proton antiporter YP_002399698.1 3782820 D 585397 CDS YP_002399699.1 218691487 7143239 3783811..3784797 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12805358; Product type e : enzyme; D-arabinose 5-phosphate isomerase 3784797 kdsD 7143239 kdsD Escherichia coli ED1a D-arabinose 5-phosphate isomerase YP_002399699.1 3783811 D 585397 CDS YP_002399700.1 218691488 7142501 3784818..3785384 1 NC_011745.1 forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase 3785384 kdsC 7142501 kdsC Escherichia coli ED1a 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase YP_002399700.1 3784818 D 585397 CDS YP_002399701.1 218691489 7142500 3785381..3785956 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3785956 yrbK 7142500 yrbK Escherichia coli ED1a hypothetical protein YP_002399701.1 3785381 D 585397 CDS YP_002399702.1 218691490 7143240 3785925..3786482 1 NC_011745.1 LptA; periplasmic binding protein part of a putative ABC superfamily of uptake transporters; interacts with LptB protein, the ATP binding component of the uptake system; lipopolysaccharide transport periplasmic protein LptA 3786482 lptA 7143240 lptA Escherichia coli ED1a lipopolysaccharide transport periplasmic protein LptA YP_002399702.1 3785925 D 585397 CDS YP_002399703.1 218691491 7141915 3786489..3787214 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7876255, 9298646, 17056748; Product type pt : putative transporter; putative ABC transporter ATP-binding protein YhbG 3787214 lptB 7141915 lptB Escherichia coli ED1a putative ABC transporter ATP-binding protein YhbG YP_002399703.1 3786489 D 585397 CDS YP_002399704.1 218691492 7141916 3787262..3788695 1 NC_011745.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen; RNA polymerase factor sigma-54 3788695 rpoN 7141916 rpoN Escherichia coli ED1a RNA polymerase factor sigma-54 YP_002399704.1 3787262 D 585397 CDS YP_002399705.1 218691493 7141490 3788718..3789005 1 NC_011745.1 YhbH; resting ribosome-binding protein involved in ribosome stabilization and preservation in stationary phase; binds specifically 100S ribosomes (an inactive ribosome product of a 70S ribosome dimerization); seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing; putative sigma(54) modulation protein 3789005 yhbH 7141490 yhbH Escherichia coli ED1a putative sigma(54) modulation protein YP_002399705.1 3788718 D 585397 CDS YP_002399706.1 218691494 7139477 3789123..3789614 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88212176, 90136533, 90274974, 95020584, 95181483, 7876255, 8025669, 8444818, 9636714; Product type t : transporter; PTS system transporter subunit IIA-like nitrogen-regulatory protein PtsN 3789614 ptsN 7139477 ptsN Escherichia coli ED1a PTS system transporter subunit IIA-like nitrogen-regulatory protein PtsN YP_002399706.1 3789123 D 585397 CDS YP_002399707.1 218691495 7141211 3789660..3790514 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3790514 yhbJ 7141211 yhbJ Escherichia coli ED1a hypothetical protein YP_002399707.1 3789660 D 585397 CDS YP_002399708.1 218691496 7139478 3790511..3790783 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10473571, 95181483, 7876255, 8025669; Product type t : transporter; phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) 3790783 npr 7139478 npr Escherichia coli ED1a phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) YP_002399708.1 3790511 D 585397 CDS YP_002399709.1 218691497 7139756 3790997..3791629 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 89083480; hypothetical protein 3791629 yrbL 7139756 yrbL Escherichia coli ED1a hypothetical protein YP_002399709.1 3790997 D 585397 CDS YP_002399710.1 218691498 7143241 complement(3791626..3792354) 1 NC_011745.1 glycosyltransferase; polymerizes glycan strands in the peptidoglycan; monofunctional biosynthetic peptidoglycan transglycosylase 3792354 mtgA 7143241 mtgA Escherichia coli ED1a monofunctional biosynthetic peptidoglycan transglycosylase YP_002399710.1 3791626 R 585397 CDS YP_002399711.1 218691499 7139037 complement(3792351..3793004) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92246944, 98269038, 1575737, 9603997; Product type pe : putative enzyme; isoprenoid biosynthesis protein with amidotransferase-like domain 3793004 elbB 7139037 elbB Escherichia coli ED1a isoprenoid biosynthesis protein with amidotransferase-like domain YP_002399711.1 3792351 R 585397 CDS YP_002399712.1 218691500 7141351 complement(3793234..3795570) 1 NC_011745.1 sensor-regulator protein which regulates the expression of many genes in response to respiratory growth conditions including anaerobic repression of the arc modulon; hybrid sensory histidine kinase in two-component regulatory system with ArcA; aerobic respiration control sensor protein ArcB 3795570 arcB 7141351 arcB Escherichia coli ED1a aerobic respiration control sensor protein ArcB YP_002399712.1 3793234 R 585397 CDS YP_002399713.1 218691501 7142606 complement(3795666..3796595) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Fe-S oxidoreductase 3796595 yhcC 7142606 yhcC Escherichia coli ED1a putative Fe-S oxidoreductase YP_002399713.1 3795666 R 585397 CDS YP_002399714.1 218691502 7139490 3797177..3801730 1 NC_011745.1 catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate; glutamate synthase subunit alpha 3801730 gltB 7139490 gltB Escherichia coli ED1a glutamate synthase subunit alpha YP_002399714.1 3797177 D 585397 CDS YP_002399715.1 218691503 7142979 3801743..3803161 1 NC_011745.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; glutamate synthase subunit beta 3803161 gltD 7142979 gltD Escherichia coli ED1a glutamate synthase subunit beta YP_002399715.1 3801743 D 585397 CDS YP_002399716.1 218691504 7142980 complement(3803229..3803693) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3803693 yhcH 7142980 yhcH Escherichia coli ED1a hypothetical protein YP_002399716.1 3803229 R 585397 CDS YP_002399717.1 218691505 7139491 complement(3803690..3804565) 1 NC_011745.1 catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein; N-acetylmannosamine kinase 3804565 nanK 7139491 nanK Escherichia coli ED1a N-acetylmannosamine kinase YP_002399717.1 3803690 R 585397 CDS YP_002399718.1 218691506 7140345 complement(3804562..3805251) 1 NC_011745.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase 3805251 nanE 7140345 nanE Escherichia coli ED1a N-acetylmannosamine-6-phosphate 2-epimerase YP_002399718.1 3804562 R 585397 CDS YP_002399719.1 218691507 7140343 complement(3805299..3806789) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96011396, 9864311, 7592358; Product type t : transporter; putative sialic acid transporter 3806789 nanT 7140343 nanT Escherichia coli ED1a putative sialic acid transporter YP_002399719.1 3805299 R 585397 CDS YP_002399720.1 218691508 7140349 complement(3806898..3807791) 1 NC_011745.1 catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid; N-acetylneuraminate lyase 3807791 nanA 7140349 nanA Escherichia coli ED1a N-acetylneuraminate lyase YP_002399720.1 3806898 R 585397 CDS YP_002399721.1 218691509 7140342 complement(3807913..3808704) 1 NC_011745.1 Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization; transcriptional regulator NanR 3808704 nanR 7140342 nanR Escherichia coli ED1a transcriptional regulator NanR YP_002399721.1 3807913 R 585397 CDS YP_002399722.1 218691510 7140347 complement(3808812..3809309) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12445774, 94293773, 1721886, 3029697, 8022275; Product type f : factor; ClpXP protease specificity-enhancing factor 3809309 sspB 7140347 sspB Escherichia coli ED1a ClpXP protease specificity-enhancing factor YP_002399722.1 3808812 R 585397 CDS YP_002399723.1 218691511 7143852 complement(3809315..3809953) 1 NC_011745.1 transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation; stringent starvation protein A 3809953 sspA 7143852 sspA Escherichia coli ED1a stringent starvation protein A YP_002399723.1 3809315 R 585397 CDS YP_002399724.1 218691512 7143851 complement(3810348..3810740) 1 NC_011745.1 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 3810740 rpsI 7143851 rpsI Escherichia coli ED1a 30S ribosomal protein S9 YP_002399724.1 3810348 R 585397 CDS YP_002399725.1 218691513 7140092 complement(3810756..3811184) 1 NC_011745.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 3811184 rplM 7140092 rplM Escherichia coli ED1a 50S ribosomal protein L13 YP_002399725.1 3810756 R 585397 CDS YP_002399726.1 218691514 7141462 complement(3811404..3812531) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3812531 yhcM 7141462 yhcM Escherichia coli ED1a hypothetical protein YP_002399726.1 3811404 R 585397 CDS YP_002399727.1 218691515 7139492 3812725..3813123 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16079137; Product type pe : putative enzyme; cytochrome d ubiquinol oxidase subunit III 3813123 yhcB 7139492 yhcB Escherichia coli ED1a cytochrome d ubiquinol oxidase subunit III YP_002399727.1 3812725 D 585397 CDS YP_002399728.1 218691516 7139489 3813277..3814644 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8830688, 96165272, 8576051, 8576052, 9740056; Product type e : enzyme; serine endoprotease 3814644 degQ 7139489 degQ Escherichia coli ED1a serine endoprotease YP_002399728.1 3813277 D 585397 CDS YP_002399729.1 218691517 7143087 3814734..3815801 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15137941, 15225661, 21352996, 96165272, 99431977, 3322223, 8576051; Product type e : enzyme; serine endoprotease 3815801 degS 7143087 degS Escherichia coli ED1a serine endoprotease YP_002399729.1 3814734 D 585397 CDS YP_002399730.1 218691518 7143088 complement(3815864..3816802) 1 NC_011745.1 oxidizes malate to oxaloacetate; malate dehydrogenase 3816802 mdh 7143088 mdh Escherichia coli ED1a malate dehydrogenase YP_002399730.1 3815864 R 585397 CDS YP_002399731.1 218691519 7142219 3817237..3817707 1 NC_011745.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor 3817707 argR 7142219 argR Escherichia coli ED1a arginine repressor YP_002399731.1 3817237 D 585397 CDS YP_002399732.1 218691520 7142619 3818071..3818334 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3818334 yhcN 7142619 yhcN Escherichia coli ED1a hypothetical protein YP_002399732.1 3818071 D 585397 CDS YP_002399733.1 218691521 7139493 complement(3818389..3818661) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative barnase inhibitor 3818661 yhcO 7139493 yhcO Escherichia coli ED1a putative barnase inhibitor YP_002399733.1 3818389 R 585397 CDS YP_002399734.1 218691522 7139494 complement(3818753..3820720) 1 NC_011745.1 with AaeA forms an efflux pump whose substrates are p-hydroxybenzoic acid 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeB 3820720 aaeB 7139494 aaeB Escherichia coli ED1a p-hydroxybenzoic acid efflux subunit AaeB YP_002399734.1 3818753 R 585397 CDS YP_002399735.1 218691523 7140642 complement(3820726..3821658) 1 NC_011745.1 with AaeB forms an efflux pump whose substrates are p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeA 3821658 aaeA 7140642 aaeA Escherichia coli ED1a p-hydroxybenzoic acid efflux subunit AaeA YP_002399735.1 3820726 R 585397 CDS YP_002399736.1 218691524 7140641 complement(3821666..3821869) 1 NC_011745.1 membrane protein AaeX; the gene is a member of the aaeXAB operon; hypothetical protein 3821869 aaeX 7140641 aaeX Escherichia coli ED1a hypothetical protein YP_002399736.1 3821666 R 585397 CDS YP_002399737.1 218691525 7140644 3822052..3822981 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15489430; Product type r : regulator; putative DNA-binding transcriptional regulator 3822981 aaeR 7140644 aaeR Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002399737.1 3822052 D 585397 CDS YP_002399738.1 218691526 7140643 complement(3823109..3824554) 1 NC_011745.1 responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase; degrades the E. coli plasmid F-encoded CcdA; protease TldD 3824554 tldD 7140643 tldD Escherichia coli ED1a protease TldD YP_002399738.1 3823109 R 585397 CDS YP_002399739.1 218691527 7141561 complement(3824710..3828510) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10960106; Product type pm : putative membrane component; hypothetical protein 3828510 yhdP 7141561 yhdP Escherichia coli ED1a hypothetical protein YP_002399739.1 3824710 R 585397 CDS YP_002399740.1 218691528 7139500 complement(3828578..3830047) 1 NC_011745.1 involved in the processing of the 5'end of 16S rRNA; ribonuclease G 3830047 rng 7139500 rng Escherichia coli ED1a ribonuclease G YP_002399740.1 3828578 R 585397 CDS YP_002399741.1 218691529 7141436 complement(3830037..3830630) 1 NC_011745.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 3830630 yhdE 7141436 yhdE Escherichia coli ED1a Maf-like protein YP_002399741.1 3830037 R 585397 CDS YP_002399742.1 218691530 7139495 complement(3830639..3831127) 1 NC_011745.1 part of cell wall structural complex MreBCD; transmembrane component; rod shape-determining protein MreD 3831127 mreD 7139495 mreD Escherichia coli ED1a rod shape-determining protein MreD YP_002399742.1 3830639 R 585397 CDS YP_002399743.1 218691531 7139028 complement(3831111..3831242) 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 3831242 7139028 ECED1_3899 Escherichia coli ED1a hypothetical protein YP_002399743.1 3831111 R 585397 CDS YP_002399744.1 218691532 7142289 complement(3831127..3832230) 1 NC_011745.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC 3832230 mreC 7142289 mreC Escherichia coli ED1a rod shape-determining protein MreC YP_002399744.1 3831127 R 585397 CDS YP_002399745.1 218691533 7139027 complement(3832296..3833339) 1 NC_011745.1 functions in MreBCD complex in some organisms; rod shape-determining protein MreB 3833339 mreB 7139027 mreB Escherichia coli ED1a rod shape-determining protein MreB YP_002399745.1 3832296 R 585397 CDS YP_002399746.1 218691534 7139026 3833447..3833635 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 3833635 7139026 ECED1_3902 Escherichia coli ED1a hypothetical protein YP_002399746.1 3833447 D 585397 CDS YP_002399747.1 218691535 7142290 complement(3833644..3835584) 1 NC_011745.1 regulates the degradation of the small RNAs CsrB and CsrC; may function to targate RNase E to specific RNA molecules; regulatory protein CsrD 3835584 csrD 7142290 csrD Escherichia coli ED1a regulatory protein CsrD YP_002399747.1 3833644 R 585397 CDS YP_002399748.1 218691536 7142078 3835736..3836710 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase, Zn-dependent and NAD(P)-binding 3836710 yhdH 7142078 yhdH Escherichia coli ED1a putative oxidoreductase, Zn-dependent and NAD(P)-binding YP_002399748.1 3835736 D 585397 CDS YP_002399749.1 218691537 7139496 3836747..3837010 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 3837010 7139496 ECED1_3905 Escherichia coli ED1a hypothetical protein YP_002399749.1 3836747 D 585397 CDS YP_002399750.1 218691538 7142291 3837690..3838160 1 NC_011745.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 3838160 accB 7142291 accB Escherichia coli ED1a acetyl-CoA carboxylase biotin carboxyl carrier protein subunit YP_002399750.1 3837690 D 585397 CDS YP_002399751.1 218691539 7143633 3838171..3839520 1 NC_011745.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 3839520 accC 7143633 accC Escherichia coli ED1a acetyl-CoA carboxylase biotin carboxylase subunit YP_002399751.1 3838171 D 585397 CDS YP_002399752.1 218691540 7143634 complement(3839612..3840658) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3840658 7143634 ECED1_3908 Escherichia coli ED1a hypothetical protein YP_002399752.1 3839612 R 585397 CDS YP_002399753.1 218691541 7142292 complement(3840655..3841617) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative carbohydrate kinase 3841617 7142292 ECED1_3909 Escherichia coli ED1a putative carbohydrate kinase YP_002399753.1 3840655 R 585397 CDS YP_002399754.1 218691542 7142293 complement(3841639..3842628) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter membrane protein 3842628 7142293 ECED1_3910 Escherichia coli ED1a putative sugar ABC transporter membrane protein YP_002399754.1 3841639 R 585397 CDS YP_002399755.1 218691543 7142294 complement(3842629..3844158) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter ATP-binding protein 3844158 7142294 ECED1_3911 Escherichia coli ED1a putative sugar ABC transporter ATP-binding protein YP_002399755.1 3842629 R 585397 CDS YP_002399756.1 218691544 7142295 complement(3844189..3845085) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC-type sugar transport system, periplasmic component 3845085 7142295 ECED1_3912 Escherichia coli ED1a putative ABC-type sugar transport system, periplasmic component YP_002399756.1 3844189 R 585397 CDS YP_002399757.1 218691545 7142296 complement(3845115..3845969) 1 NC_011745.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway; tagatose-bisphosphate aldolase 3845969 gatY 7142296 gatY Escherichia coli ED1a tagatose-bisphosphate aldolase YP_002399757.1 3845115 R 585397 CDS YP_002399758.1 218691546 7142297 3846311..3847141 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DEOR-type transcriptional regulator 3847141 7142297 ECED1_3914 Escherichia coli ED1a putative DEOR-type transcriptional regulator YP_002399758.1 3846311 D 585397 CDS YP_002399759.1 218691547 7142298 3847098..3848108 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative pfkB family carbohydrate kinase 3848108 7142298 ECED1_3915 Escherichia coli ED1a putative pfkB family carbohydrate kinase YP_002399759.1 3847098 D 585397 CDS YP_002399760.1 218691548 7142299 3848201..3848443 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3848443 yhdT 7142299 yhdT Escherichia coli ED1a hypothetical protein YP_002399760.1 3848201 D 585397 CDS YP_002399761.1 218691549 7139501 3848433..3849884 1 NC_011745.1 mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase; sodium/panthothenate symporter 3849884 panF 7139501 panF Escherichia coli ED1a sodium/panthothenate symporter YP_002399761.1 3848433 D 585397 CDS YP_002399762.1 218691550 7144043 3849896..3850777 1 NC_011745.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; ribosomal protein L11 methyltransferase 3850777 prmA 7144043 prmA Escherichia coli ED1a ribosomal protein L11 methyltransferase YP_002399762.1 3849896 D 585397 CDS YP_002399763.1 218691551 7139124 3851106..3852071 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 22095566, 1459953, 1547773, 2835774, 2837762, 8226664; Product type e : enzyme; tRNA-dihydrouridine synthase B 3852071 dusB 7139124 dusB Escherichia coli ED1a tRNA-dihydrouridine synthase B YP_002399763.1 3851106 D 585397 CDS YP_002399764.1 218691552 7140532 3852097..3852393 1 NC_011745.1 Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription; DNA-binding protein Fis 3852393 fis 7140532 fis Escherichia coli ED1a DNA-binding protein Fis YP_002399764.1 3852097 D 585397 CDS YP_002399765.1 218691553 7144187 3852479..3853363 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15028690, 9073062; Product type e : enzyme; putative methyltransferase 3853363 yhdJ 7144187 yhdJ Escherichia coli ED1a putative methyltransferase YP_002399765.1 3852479 D 585397 CDS YP_002399766.1 218691554 7139497 3853447..3853626 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3853626 yhdU 7139497 yhdU Escherichia coli ED1a hypothetical protein YP_002399766.1 3853447 D 585397 CDS YP_002399767.1 218691555 7139502 complement(3853629..3854291) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8203018, 11257026, 8407802, 1720861; Product type r : regulator; DNA-binding transcriptional regulator EnvR 3854291 envR 7139502 envR Escherichia coli ED1a DNA-binding transcriptional regulator EnvR YP_002399767.1 3853629 R 585397 CDS YP_002399768.1 218691556 7139801 3854690..3855847 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94012493, 1720861; Product type lp : lipoprotein; cytoplasmic membrane lipoprotein 3855847 acrE 7139801 acrE Escherichia coli ED1a cytoplasmic membrane lipoprotein YP_002399768.1 3854690 D 585397 CDS YP_002399769.1 218691557 7143652 3855859..3858963 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94262163, 99449638, 1720861, 8407802; Product type t : transporter; multidrug efflux system protein 3858963 acrF 7143652 acrF Escherichia coli ED1a multidrug efflux system protein YP_002399769.1 3855859 D 585397 CDS YP_002399770.1 218691558 7143653 3859001..3859189 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 3859189 7143653 ECED1_3926 Escherichia coli ED1a hypothetical protein YP_002399770.1 3859001 D 585397 CDS YP_002399771.1 218691559 7142300 3859095..3859604 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase IS605 family, IS200 group 3859604 7142300 ECED1_3927 Escherichia coli ED1a transposase IS605 family, IS200 group YP_002399771.1 3859095 D 585397 CDS YP_002399772.1 218691560 7142301 3859928..3860149 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3860149 yhdV 7142301 yhdV Escherichia coli ED1a hypothetical protein YP_002399772.1 3859928 D 585397 CDS YP_002399773.1 218691561 7139503 3860375..3860551 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3860551 7139503 ECED1_3929 Escherichia coli ED1a hypothetical protein YP_002399773.1 3860375 D 585397 CDS YP_002399774.1 218691562 7142302 3860688..3861605 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8898392; Product type t : transporter; amino-acid ABC transporter periplasmic-binding protein 3861605 aapJ 7142302 aapJ Escherichia coli ED1a amino-acid ABC transporter periplasmic-binding protein YP_002399774.1 3860688 D 585397 CDS YP_002399775.1 218691563 7140645 3861673..3862854 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8898392; Product type t : transporter; amino-acid ABC transporter membrane protein 3862854 aapQ 7140645 aapQ Escherichia coli ED1a amino-acid ABC transporter membrane protein YP_002399775.1 3861673 D 585397 CDS YP_002399776.1 218691564 7140648 3862864..3863967 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8898392; Product type t : transporter; amino-acid ABC transporter membrane protein 3863967 aapM 7140648 aapM Escherichia coli ED1a amino-acid ABC transporter membrane protein YP_002399776.1 3862864 D 585397 CDS YP_002399777.1 218691565 7140646 3863975..3864733 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8809753, 8898392; Product type t : transporter; amino-acid ABC transporter ATP-binding protein 3864733 aapP 7140646 aapP Escherichia coli ED1a amino-acid ABC transporter ATP-binding protein YP_002399777.1 3863975 D 585397 CDS YP_002399778.1 218691566 7142816 3870288..3871169 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3871169 yrdA 7142816 yrdA Escherichia coli ED1a hypothetical protein YP_002399778.1 3870288 D 585397 CDS YP_002399779.1 218691567 7143242 complement(3871145..3871402) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3871402 yrdB 7143242 yrdB Escherichia coli ED1a hypothetical protein YP_002399779.1 3871145 R 585397 CDS YP_002399780.1 218691568 7143243 complement(3871399..3872217) 1 NC_011745.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 3872217 aroE 7143243 aroE Escherichia coli ED1a shikimate 5-dehydrogenase YP_002399780.1 3871399 R 585397 CDS YP_002399781.1 218691569 7142627 complement(3872222..3872794) 1 NC_011745.1 RimN; YrdC; required for maturation of 16s RNA; binds preferentially double stranded RNA; putative ribosome maturation factor 3872794 yrdC 7142627 yrdC Escherichia coli ED1a putative ribosome maturation factor YP_002399781.1 3872222 R 585397 CDS YP_002399782.1 218691570 7143244 complement(3872799..3873341) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative DNA topoisomerase 3873341 yrdD 7143244 yrdD Escherichia coli ED1a putative DNA topoisomerase YP_002399782.1 3872799 R 585397 CDS YP_002399783.1 218691571 7143245 complement(3873370..3873843) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8432722; hypothetical protein 3873843 smg 7143245 smg Escherichia coli ED1a hypothetical protein YP_002399783.1 3873370 R 585397 CDS YP_002399784.1 218691572 7143810 complement(3873815..3874939) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8112305, 8432722; DNA protecting protein DprA 3874939 smf 7143810 smf Escherichia coli ED1a DNA protecting protein DprA YP_002399784.1 3873815 R 585397 CDS YP_002399785.1 218691573 7143809 3875069..3875578 1 NC_011745.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 3875578 def 7143809 def Escherichia coli ED1a peptide deformylase YP_002399785.1 3875069 D 585397 CDS YP_002399786.1 218691574 7143085 3875593..3876540 1 NC_011745.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 3876540 fmt 7143085 fmt Escherichia coli ED1a methionyl-tRNA formyltransferase YP_002399786.1 3875593 D 585397 CDS YP_002399787.1 218691575 7142152 3876592..3877881 1 NC_011745.1 catalyzes the methylation of cytosine at position 967 (m5C967) of 16S rRNA; SAM-dependent methyltransferase; 16S rRNA methyltransferase B 3877881 rsmB 7142152 rsmB Escherichia coli ED1a 16S rRNA methyltransferase B YP_002399787.1 3876592 D 585397 CDS YP_002399788.1 218691576 7140114 3877903..3879279 1 NC_011745.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane component 3879279 trkA 7140114 trkA Escherichia coli ED1a potassium transporter peripheral membrane component YP_002399788.1 3877903 D 585397 CDS YP_002399789.1 218691577 7140810 3879409..3879822 1 NC_011745.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel 3879822 mscL 7140810 mscL Escherichia coli ED1a large-conductance mechanosensitive channel YP_002399789.1 3879409 D 585397 CDS YP_002399790.1 218691578 7139032 complement(3879819..3880037) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3880037 yhdL 7139032 yhdL Escherichia coli ED1a hypothetical protein YP_002399790.1 3879819 R 585397 CDS YP_002399791.1 218691579 7139498 complement(3880093..3880518) 1 NC_011745.1 mediates expression of the zinc export protein ZntA in response to high levels of zinc; member of MerR family of transcriptional regulators; zinc-responsive transcriptional regulator 3880518 zntR 7139498 zntR Escherichia coli ED1a zinc-responsive transcriptional regulator YP_002399791.1 3880093 R 585397 CDS YP_002399792.1 218691580 7143277 complement(3880529..3880897) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3880897 yhdN 7143277 yhdN Escherichia coli ED1a hypothetical protein YP_002399792.1 3880529 R 585397 CDS YP_002399793.1 218691581 7139499 complement(3881003..3881386) 1 NC_011745.1 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 3881386 rplQ 7139499 rplQ Escherichia coli ED1a 50S ribosomal protein L17 YP_002399793.1 3881003 R 585397 CDS YP_002399794.1 218691582 7141466 complement(3881427..3882416) 1 NC_011745.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 3882416 rpoA 7141466 rpoA Escherichia coli ED1a DNA-directed RNA polymerase subunit alpha YP_002399794.1 3881427 R 585397 CDS YP_002399795.1 218691583 7141484 complement(3882442..3883062) 1 NC_011745.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 3883062 rpsD 7141484 rpsD Escherichia coli ED1a 30S ribosomal protein S4 YP_002399795.1 3882442 R 585397 CDS YP_002399796.1 218691584 7140087 complement(3883096..3883485) 1 NC_011745.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 3883485 rpsK 7140087 rpsK Escherichia coli ED1a 30S ribosomal protein S11 YP_002399796.1 3883096 R 585397 CDS YP_002399797.1 218691585 7140094 complement(3883502..3883858) 1 NC_011745.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 3883858 rpsM 7140094 rpsM Escherichia coli ED1a 30S ribosomal protein S13 YP_002399797.1 3883502 R 585397 CDS YP_002399798.1 218691586 7140096 complement(3884153..3885484) 1 NC_011745.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 3885484 secY 7140096 secY Escherichia coli ED1a preprotein translocase subunit SecY YP_002399798.1 3884153 R 585397 CDS YP_002399799.1 218691587 7141392 complement(3885492..3885926) 1 NC_011745.1 late assembly protein; 50S ribosomal protein L15 3885926 rplO 7141392 rplO Escherichia coli ED1a 50S ribosomal protein L15 YP_002399799.1 3885492 R 585397 CDS YP_002399800.1 218691588 7141464 complement(3885930..3886109) 1 NC_011745.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 3886109 rpmD 7141464 rpmD Escherichia coli ED1a 50S ribosomal protein L30 YP_002399800.1 3885930 R 585397 CDS YP_002399801.1 218691589 7141478 complement(3886113..3886616) 1 NC_011745.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 3886616 rpsE 7141478 rpsE Escherichia coli ED1a 30S ribosomal protein S5 YP_002399801.1 3886113 R 585397 CDS YP_002399802.1 218691590 7140088 complement(3886631..3886984) 1 NC_011745.1 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 3886984 rplR 7140088 rplR Escherichia coli ED1a 50S ribosomal protein L18 YP_002399802.1 3886631 R 585397 CDS YP_002399803.1 218691591 7141467 complement(3886994..3887527) 1 NC_011745.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 3887527 rplF 7141467 rplF Escherichia coli ED1a 50S ribosomal protein L6 YP_002399803.1 3886994 R 585397 CDS YP_002399804.1 218691592 7141457 complement(3887540..3887932) 1 NC_011745.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 3887932 rpsH 7141457 rpsH Escherichia coli ED1a 30S ribosomal protein S8 YP_002399804.1 3887540 R 585397 CDS YP_002399805.1 218691593 7140091 complement(3887966..3888271) 1 NC_011745.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 3888271 rpsN 7140091 rpsN Escherichia coli ED1a 30S ribosomal protein S14 YP_002399805.1 3887966 R 585397 CDS YP_002399806.1 218691594 7140097 complement(3888286..3888825) 1 NC_011745.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 3888825 rplE 7140097 rplE Escherichia coli ED1a 50S ribosomal protein L5 YP_002399806.1 3888286 R 585397 CDS YP_002399807.1 218691595 7141456 complement(3888840..3889154) 1 NC_011745.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 3889154 rplX 7141456 rplX Escherichia coli ED1a 50S ribosomal protein L24 YP_002399807.1 3888840 R 585397 CDS YP_002399808.1 218691596 7141473 complement(3889165..3889536) 1 NC_011745.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 3889536 rplN 7141473 rplN Escherichia coli ED1a 50S ribosomal protein L14 YP_002399808.1 3889165 R 585397 CDS YP_002399809.1 218691597 7141463 complement(3889701..3889955) 1 NC_011745.1 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 3889955 rpsQ 7141463 rpsQ Escherichia coli ED1a 30S ribosomal protein S17 YP_002399809.1 3889701 R 585397 CDS YP_002399810.1 218691598 7140100 complement(3889955..3890146) 1 NC_011745.1 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 3890146 rpmC 7140100 rpmC Escherichia coli ED1a 50S ribosomal protein L29 YP_002399810.1 3889955 R 585397 CDS YP_002399811.1 218691599 7141477 complement(3890146..3890556) 1 NC_011745.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 3890556 rplP 7141477 rplP Escherichia coli ED1a 50S ribosomal protein L16 YP_002399811.1 3890146 R 585397 CDS YP_002399812.1 218691600 7141465 complement(3890569..3891270) 1 NC_011745.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 3891270 rpsC 7141465 rpsC Escherichia coli ED1a 30S ribosomal protein S3 YP_002399812.1 3890569 R 585397 CDS YP_002399813.1 218691601 7140086 complement(3891288..3891620) 1 NC_011745.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 3891620 rplV 7140086 rplV Escherichia coli ED1a 50S ribosomal protein L22 YP_002399813.1 3891288 R 585397 CDS YP_002399814.1 218691602 7141471 complement(3891635..3891913) 1 NC_011745.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 3891913 rpsS 7141471 rpsS Escherichia coli ED1a 30S ribosomal protein S19 YP_002399814.1 3891635 R 585397 CDS YP_002399815.1 218691603 7140102 complement(3891930..3892751) 1 NC_011745.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 3892751 rplB 7140102 rplB Escherichia coli ED1a 50S ribosomal protein L2 YP_002399815.1 3891930 R 585397 CDS YP_002399816.1 218691604 7141453 complement(3892769..3893071) 1 NC_011745.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 3893071 rplW 7141453 rplW Escherichia coli ED1a 50S ribosomal protein L23 YP_002399816.1 3892769 R 585397 CDS YP_002399817.1 218691605 7141472 complement(3893068..3893673) 1 NC_011745.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 3893673 rplD 7141472 rplD Escherichia coli ED1a 50S ribosomal protein L4 YP_002399817.1 3893068 R 585397 CDS YP_002399818.1 218691606 7141455 complement(3893684..3894313) 1 NC_011745.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 3894313 rplC 7141455 rplC Escherichia coli ED1a 50S ribosomal protein L3 YP_002399818.1 3893684 R 585397 CDS YP_002399819.1 218691607 7141454 complement(3894346..3894657) 1 NC_011745.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 3894657 rpsJ 7141454 rpsJ Escherichia coli ED1a 30S ribosomal protein S10 YP_002399819.1 3894346 R 585397 CDS YP_002399820.1 218691608 7140093 complement(3894895..3895314) 1 NC_011745.1 calcium-binding protein that may be required for the initiation of chromosome replication; chromosome replication protein PioO 3895314 pioO 7140093 pioO Escherichia coli ED1a chromosome replication protein PioO YP_002399820.1 3894895 R 585397 CDS YP_002399821.1 218691609 7143031 3896965..3897780 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 96256608; Product type t : transporter; general secretory pathway component, cryptic 3897780 gspC 7143031 gspC Escherichia coli ED1a general secretory pathway component, cryptic YP_002399821.1 3896965 D 585397 CDS YP_002399822.1 218691610 7143032 3897764..3899716 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 96256608; Product type t : transporter; general secretory pathway component, cryptic 3899716 gspD 7143032 gspD Escherichia coli ED1a general secretory pathway component, cryptic YP_002399822.1 3897764 D 585397 CDS YP_002399823.1 218691611 7143033 3899726..3901207 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 96256608; Product type t : transporter; general secretory pathway component, cryptic 3901207 gspE 7143033 gspE Escherichia coli ED1a general secretory pathway component, cryptic YP_002399823.1 3899726 D 585397 CDS YP_002399824.1 218691612 7143034 3901204..3902400 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 96256608, 7896718; Product type t : transporter; general secretory pathway component, cryptic 3902400 gspF 7143034 gspF Escherichia coli ED1a general secretory pathway component, cryptic YP_002399824.1 3901204 D 585397 CDS YP_002399825.1 218691613 7143035 3902410..3902847 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 95204361, 96256608; Product type t : transporter; pseudopilin, cryptic, general secretion pathway 3902847 gspG 7143035 gspG Escherichia coli ED1a pseudopilin, cryptic, general secretion pathway YP_002399825.1 3902410 D 585397 CDS YP_002399826.1 218691614 7143036 3902855..3903364 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96256608; Product type pt : putative transporter; putative general secretory pathway component, cryptic 3903364 gspH 7143036 gspH Escherichia coli ED1a putative general secretory pathway component, cryptic YP_002399826.1 3902855 D 585397 CDS YP_002399827.1 218691615 7139755 3903361..3903738 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 96256608, 1588814; Product type t : transporter; general secretory pathway component, cryptic 3903738 gspI 7139755 gspI Escherichia coli ED1a general secretory pathway component, cryptic YP_002399827.1 3903361 D 585397 CDS YP_002399828.1 218691616 7139839 3903731..3904318 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96256608; Product type pt : putative transporter; putative general secretory pathway component, cryptic 3904318 gspJ 7139839 gspJ Escherichia coli ED1a putative general secretory pathway component, cryptic YP_002399828.1 3903731 D 585397 CDS YP_002399829.1 218691617 7139840 complement(3904356..3904559) 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 3904559 7139840 ECED1_3997 Escherichia coli ED1a hypothetical protein YP_002399829.1 3904356 R 585397 CDS YP_002399830.1 218691618 7142303 complement(3904749..3907274) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10760150, 10419961, 2661540; Product type e : enzyme; periplasmic endochitinase 3907274 chiA 7142303 chiA Escherichia coli ED1a periplasmic endochitinase YP_002399830.1 3904749 R 585397 CDS YP_002399831.1 218691619 7139344 complement(3907566..3908750) 1 NC_011745.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 3908750 tufA 7139344 tufA Escherichia coli ED1a elongation factor Tu YP_002399831.1 3907566 R 585397 CDS YP_002399832.1 218691620 7140842 complement(3908821..3910935) 1 NC_011745.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 3910935 fusA 7140842 fusA Escherichia coli ED1a elongation factor G YP_002399832.1 3908821 R 585397 CDS YP_002399833.1 218691621 7143135 complement(3911032..3911502) 1 NC_011745.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 3911502 rpsG 7143135 rpsG Escherichia coli ED1a 30S ribosomal protein S7 YP_002399833.1 3911032 R 585397 CDS YP_002399834.1 218691622 7140090 complement(3911599..3911973) 1 NC_011745.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 3911973 rpsL 7140090 rpsL Escherichia coli ED1a 30S ribosomal protein S12 YP_002399834.1 3911599 R 585397 CDS YP_002399835.1 218691623 7140095 complement(3912099..3912386) 1 NC_011745.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusB 3912386 tusB 7140095 tusB Escherichia coli ED1a sulfur transfer complex subunit TusB YP_002399835.1 3912099 R 585397 CDS YP_002399836.1 218691624 7140846 complement(3912393..3912752) 1 NC_011745.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur relay protein TusC 3912752 tusC 7140846 tusC Escherichia coli ED1a sulfur relay protein TusC YP_002399836.1 3912393 R 585397 CDS YP_002399837.1 218691625 7140847 complement(3912752..3913138) 1 NC_011745.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusD 3913138 tusD 7140847 tusD Escherichia coli ED1a sulfur transfer complex subunit TusD YP_002399837.1 3912752 R 585397 CDS YP_002399838.1 218691626 7140848 complement(3913138..3913860) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3913860 yheO 7140848 yheO Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002399838.1 3913138 R 585397 CDS YP_002399839.1 218691627 7139504 complement(3914027..3914839) 1 NC_011745.1 rotamase; FKBP-type peptidyl-prolyl cis-trans isomerase 3914839 fkpA 7139504 fkpA Escherichia coli ED1a FKBP-type peptidyl-prolyl cis-trans isomerase YP_002399839.1 3914027 R 585397 CDS YP_002399840.1 218691628 7144194 3915060..3915278 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3915278 slyX 7144194 slyX Escherichia coli ED1a hypothetical protein YP_002399840.1 3915060 D 585397 CDS YP_002399841.1 218691629 7143808 complement(3915327..3915917) 1 NC_011745.1 rotamase; FKBP-type peptidyl-prolyl cis-trans isomerase 3915917 slyD 7143808 slyD Escherichia coli ED1a FKBP-type peptidyl-prolyl cis-trans isomerase YP_002399841.1 3915327 R 585397 CDS YP_002399842.1 218691630 7143807 complement(3916012..3916212) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3916212 yheV 7143807 yheV Escherichia coli ED1a hypothetical protein YP_002399842.1 3916012 R 585397 CDS YP_002399843.1 218691631 7139508 complement(3916222..3918027) 1 NC_011745.1 involved in potassium efflux; glutathione-regulated potassium-efflux system protein KefB 3918027 kefB 7139508 kefB Escherichia coli ED1a glutathione-regulated potassium-efflux system protein KefB YP_002399843.1 3916222 R 585397 CDS YP_002399844.1 218691632 7142506 complement(3918027..3918581) 1 NC_011745.1 required for KefB activity; glutathione-regulated potassium-efflux system ancillary protein KefG 3918581 kefG 7142506 kefG Escherichia coli ED1a glutathione-regulated potassium-efflux system ancillary protein KefG YP_002399844.1 3918027 R 585397 CDS YP_002399845.1 218691633 7142509 3918709..3920622 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATP-binding protein 3920622 yheS 7142509 yheS Escherichia coli ED1a putative ABC transporter ATP-binding protein YP_002399845.1 3918709 D 585397 CDS YP_002399846.1 218691634 7139505 3920622..3921644 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9889164; Product type pe : putative enzyme; putative hydrolase 3921644 yheT 7139505 yheT Escherichia coli ED1a putative hydrolase YP_002399846.1 3920622 D 585397 CDS YP_002399847.1 218691635 7139506 3921638..3921856 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3921856 yheU 7139506 yheU Escherichia coli ED1a hypothetical protein YP_002399847.1 3921638 D 585397 CDS YP_002399848.1 218691636 7139507 3921910..3922779 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 2559876; Product type e : enzyme; phosphoribulokinase 3922779 prkB 7139507 prkB Escherichia coli ED1a phosphoribulokinase YP_002399848.1 3921910 D 585397 CDS YP_002399849.1 218691637 7139122 complement(3922834..3923238) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3923238 yhfA 7139122 yhfA Escherichia coli ED1a hypothetical protein YP_002399849.1 3922834 R 585397 CDS YP_002399850.1 218691638 7142057 3923318..3923533 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3923533 7142057 ECED1_4020 Escherichia coli ED1a hypothetical protein YP_002399850.1 3923318 D 585397 CDS YP_002399851.1 218691639 7142304 3923540..3924172 1 NC_011745.1 complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons; cAMP-regulatory protein 3924172 crp 7142304 crp Escherichia coli ED1a cAMP-regulatory protein YP_002399851.1 3923540 D 585397 CDS YP_002399852.1 218691640 7142056 3924211..3926313 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3926313 yhfK 7142056 yhfK Escherichia coli ED1a hypothetical protein YP_002399852.1 3924211 D 585397 CDS YP_002399853.1 218691641 7139511 complement(3926380..3927600) 1 NC_011745.1 DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate; bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein 3927600 argD 7139511 argD Escherichia coli ED1a bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein YP_002399853.1 3926380 R 585397 CDS YP_002399854.1 218691642 7142612 complement(3927686..3928249) 1 NC_011745.1 aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; para-aminobenzoate synthase component II 3928249 pabA 7142612 pabA Escherichia coli ED1a para-aminobenzoate synthase component II YP_002399854.1 3927686 R 585397 CDS YP_002399855.1 218691643 7139998 complement(3928281..3928883) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92021789, 94095125, 2007139, 2403545, 2546924, 7549107; Product type cp : cell process; cell filamentation protein Fic 3928883 fic 7139998 fic Escherichia coli ED1a cell filamentation protein Fic YP_002399855.1 3928281 R 585397 CDS YP_002399856.1 218691644 7144177 complement(3928873..3929040) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3929040 yhfG 7144177 yhfG Escherichia coli ED1a hypothetical protein YP_002399856.1 3928873 R 585397 CDS YP_002399857.1 218691645 7139510 complement(3929145..3929717) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90272647, 91175755, 1606970, 2001362, 2007139, 2190212, 2403545, 2546924, 8130188, 8180197; Product type e : enzyme; peptidyl-prolyl cis-trans isomerase A 3929717 ppiA 7139510 ppiA Escherichia coli ED1a peptidyl-prolyl cis-trans isomerase A YP_002399857.1 3929145 R 585397 CDS YP_002399858.1 218691646 7139103 3929988..3931169 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20509826; Product type pt : putative transporter; hypothetical protein 3931169 tsgA 7139103 tsgA Escherichia coli ED1a hypothetical protein YP_002399858.1 3929988 D 585397 CDS YP_002399859.1 218691647 7140835 3931431..3933974 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93062014, 2200672, 2445993, 2543955; Product type e : enzyme; nitrite reductase, large subunit, NAD(P) H-binding 3933974 nirB 7140835 nirB Escherichia coli ED1a nitrite reductase, large subunit, NAD(P) H-binding YP_002399859.1 3931431 D 585397 CDS YP_002399860.1 218691648 7140394 3933971..3934297 1 NC_011745.1 involved in reducing nitrite to ammonium to detoxify nitrite accumulation in anaerobic nitrate-respiring cells and regenerate NAD+; bounds to NirB, the cytoplasmic subunit, whose expression is induced at high nitrate concentrations; nitrite reductase small subunit 3934297 nirD 7140394 nirD Escherichia coli ED1a nitrite reductase small subunit YP_002399860.1 3933971 D 585397 CDS YP_002399861.1 218691649 7140396 3934423..3935229 1 NC_011745.1 member of the FNT family of formate and nitrite transporters; nitrite transporter NirC 3935229 nirC 7140396 nirC Escherichia coli ED1a nitrite transporter NirC YP_002399861.1 3934423 D 585397 CDS YP_002399862.1 218691650 7140395 3935248..3936621 1 NC_011745.1 multifunction enzyme consisting of uroporphyrin-III C-methyltransferase, precorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase; catalyzes the methylation of uroporphyrinogen III to form precorrin-2, then catalyzes formation of sirohydrochlorin from precorrin-2 and finally catalyzed the formation of siroheme from sirohydrochlorin; siroheme synthase 3936621 cysG 7140395 cysG Escherichia coli ED1a siroheme synthase YP_002399862.1 3935248 D 585397 CDS YP_002399863.1 218691651 7139221 3936873..3937040 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3937040 yhfL 7139221 yhfL Escherichia coli ED1a hypothetical protein YP_002399863.1 3936873 D 585397 CDS YP_002399864.1 218691652 7139512 complement(3937148..3938233) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3938233 yhfS 7139512 yhfS Escherichia coli ED1a hypothetical protein YP_002399864.1 3937148 R 585397 CDS YP_002399865.1 218691653 7139513 complement(3938245..3939549) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3939549 yhfT 7139513 yhfT Escherichia coli ED1a hypothetical protein YP_002399865.1 3938245 R 585397 CDS YP_002399866.1 218691654 7139514 complement(3939561..3939914) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3939914 yhfU 7139514 yhfU Escherichia coli ED1a hypothetical protein YP_002399866.1 3939561 R 585397 CDS YP_002399867.1 218691655 7139515 complement(3939925..3940803) 1 NC_011745.1 phosphotriesterase homology protein; PhP; YhfV; member of a family of proteins related to phosphotriesterase (PTE); putative hydrolase 3940803 php 7139515 php Escherichia coli ED1a putative hydrolase YP_002399867.1 3939925 R 585397 CDS YP_002399868.1 218691656 7144110 complement(3940800..3942026) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative mutase 3942026 yhfW 7144110 yhfW Escherichia coli ED1a putative mutase YP_002399868.1 3940800 R 585397 CDS YP_002399869.1 218691657 7139516 complement(3942027..3943190) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative amino acid racemase 3943190 yhfX 7139516 yhfX Escherichia coli ED1a putative amino acid racemase YP_002399869.1 3942027 R 585397 CDS YP_002399870.1 218691658 7139517 complement(3943274..3943636) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3943636 yhfY 7139517 yhfY Escherichia coli ED1a hypothetical protein YP_002399870.1 3943274 R 585397 CDS YP_002399871.1 218691659 7139518 complement(3943653..3944558) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3944558 yhfZ 7139518 yhfZ Escherichia coli ED1a hypothetical protein YP_002399871.1 3943653 R 585397 CDS YP_002399872.1 218691660 7139519 complement(3944718..3945722) 1 NC_011745.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 3945722 trpS 7139519 trpS Escherichia coli ED1a tryptophanyl-tRNA synthetase YP_002399872.1 3944718 R 585397 CDS YP_002399873.1 218691661 7140826 complement(3945715..3946473) 1 NC_011745.1 catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate; phosphoglycolate phosphatase 3946473 gph 7140826 gph Escherichia coli ED1a phosphoglycolate phosphatase YP_002399873.1 3945715 R 585397 CDS YP_002399874.1 218691662 7143011 complement(3946466..3947143) 1 NC_011745.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase 3947143 rpe 7143011 rpe Escherichia coli ED1a ribulose-phosphate 3-epimerase YP_002399874.1 3946466 R 585397 CDS YP_002399875.1 218691663 7141447 complement(3947161..3947997) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90136529, 92262475, 92272672, 2549371, 6300769, 7603433, 8341592; Product type e : enzyme; DNA adenine methylase 3947997 dam 7141447 dam Escherichia coli ED1a DNA adenine methylase YP_002399875.1 3947161 R 585397 CDS YP_002399876.1 218691664 7143060 complement(3948104..3949390) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3949390 damX 7143060 damX Escherichia coli ED1a hypothetical protein YP_002399876.1 3948104 R 585397 CDS YP_002399877.1 218691665 7143061 complement(3949482..3950570) 1 NC_011745.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 3950570 aroB 7143061 aroB Escherichia coli ED1a 3-dehydroquinate synthase YP_002399877.1 3949482 R 585397 CDS YP_002399878.1 218691666 7142624 complement(3950627..3951148) 1 NC_011745.1 type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase I 3951148 aroK 7142624 aroK Escherichia coli ED1a shikimate kinase I YP_002399878.1 3950627 R 585397 CDS YP_002399879.1 218691667 7142631 complement(3951549..3952787) 1 NC_011745.1 outer membrane porin probably involved in uptake of extracellular double-stranded DNA; similar to outer membrane competence protein ComE from Haemophilus influenzae and outer membrane protein PilQ involved in type IV pilus production from Pseudomonas aeruginosa; outer membrane porin HofQ 3952787 hofQ 7142631 hofQ Escherichia coli ED1a outer membrane porin HofQ YP_002399879.1 3951549 R 585397 CDS YP_002399880.1 218691668 7139908 complement(3952699..3953103) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3953103 yrfA 7139908 yrfA Escherichia coli ED1a hypothetical protein YP_002399880.1 3952699 R 585397 CDS YP_002399881.1 218691669 7143246 complement(3953093..3953533) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3953533 yrfB 7143246 yrfB Escherichia coli ED1a hypothetical protein YP_002399881.1 3953093 R 585397 CDS YP_002399882.1 218691670 7143247 complement(3953517..3954056) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial assembly protein (pilN-like) 3954056 yrfC 7143247 yrfC Escherichia coli ED1a putative fimbrial assembly protein (pilN-like) YP_002399882.1 3953517 R 585397 CDS YP_002399883.1 218691671 7143248 complement(3954056..3954835) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative pilus assembly protein 3954835 yrfD 7143248 yrfD Escherichia coli ED1a putative pilus assembly protein YP_002399883.1 3954056 R 585397 CDS YP_002399884.1 218691672 7143249 3954955..3957507 1 NC_011745.1 bifunctional murein transglycosylase/murein transpeptidase; penicillin-binding protein 1A; involved in the synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation; penicillin-insensitive transglycosylase catalyzes the formation of linear glycan strands and the penicillin-sensitive transpeptidase catalyzes the cross-linking of the peptide subunits; peptidoglycan synthetase 3957507 mrcA 7143249 mrcA Escherichia coli ED1a peptidoglycan synthetase YP_002399884.1 3954955 D 585397 CDS YP_002399885.1 218691673 7139022 complement(3957674..3958234) 1 NC_011745.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose diphosphatase NudE 3958234 nudE 7139022 nudE Escherichia coli ED1a ADP-ribose diphosphatase NudE YP_002399885.1 3957674 R 585397 CDS YP_002399886.1 218691674 7139940 3958554..3960689 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11553591; Product type r : regulator; intracellular growth attenuator protein 3960689 igaA 7139940 igaA Escherichia coli ED1a intracellular growth attenuator protein YP_002399886.1 3958554 D 585397 CDS YP_002399887.1 218691675 7140231 3960754..3961422 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase 3961422 yrfG 7140231 yrfG Escherichia coli ED1a putative hydrolase YP_002399887.1 3960754 D 585397 CDS YP_002399888.1 218691676 7143250 3961433..3961834 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9867837, 10675343, 10675344; Product type f : factor; ribosome-associated heat shock protein Hsp15 3961834 hslR 7143250 hslR Escherichia coli ED1a ribosome-associated heat shock protein Hsp15 YP_002399888.1 3961433 D 585397 CDS YP_002399889.1 218691677 7140168 3961859..3962737 1 NC_011745.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 3962737 hslO 7140168 hslO Escherichia coli ED1a Hsp33-like chaperonin YP_002399889.1 3961859 D 585397 CDS YP_002399890.1 218691678 7140167 complement(3962800..3964524) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 20223645; Product type pm : putative membrane component; hypothetical protein 3964524 yhgE 7140167 yhgE Escherichia coli ED1a hypothetical protein YP_002399890.1 3962800 R 585397 CDS YP_002399891.1 218691679 7139521 complement(3964600..3964731) 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 3964731 7139521 ECED1_4062 Escherichia coli ED1a hypothetical protein YP_002399891.1 3964600 R 585397 CDS YP_002399892.1 218691680 7142305 3964903..3966525 1 NC_011745.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase 3966525 pck 7142305 pck Escherichia coli ED1a phosphoenolpyruvate carboxykinase YP_002399892.1 3964903 D 585397 CDS YP_002399893.1 218691681 7144048 complement(3966602..3967954) 1 NC_011745.1 membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR; osmolarity sensor protein 3967954 envZ 7144048 envZ Escherichia coli ED1a osmolarity sensor protein YP_002399893.1 3966602 R 585397 CDS YP_002399894.1 218691682 7139802 complement(3967951..3968670) 1 NC_011745.1 part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation; osmolarity response regulator 3968670 ompR 7139802 ompR Escherichia coli ED1a osmolarity response regulator YP_002399894.1 3967951 R 585397 CDS YP_002399895.1 218691683 7139974 3968898..3969374 1 NC_011745.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreB 3969374 greB 7139974 greB Escherichia coli ED1a transcription elongation factor GreB YP_002399895.1 3968898 D 585397 CDS YP_002399896.1 218691684 7143020 3969471..3971792 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8755871; Product type f : factor; transcriptional accessory protein 3971792 yhgF 7143020 yhgF Escherichia coli ED1a transcriptional accessory protein YP_002399896.1 3969471 D 585397 CDS YP_002399897.1 218691685 7139522 3972248..3972475 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94012482, 8407793; Product type t : transporter; ferrous iron transport protein A 3972475 feoA 7139522 feoA Escherichia coli ED1a ferrous iron transport protein A YP_002399897.1 3972248 D 585397 CDS YP_002399898.1 218691686 7144154 3972492..3974813 1 NC_011745.1 cytoplasmic membrane ferrous uptake system permease; mutations disrupt the ability of Escherichia coli to take up ferrous iron; GTP-binding protein which requires GTP for efficient iron(II) uptake; ferrous iron transport protein B 3974813 feoB 7144154 feoB Escherichia coli ED1a ferrous iron transport protein B YP_002399898.1 3972492 D 585397 CDS YP_002399899.1 218691687 7144155 3974824..3975060 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3975060 yhgG 7144155 yhgG Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002399899.1 3974824 D 585397 CDS YP_002399900.1 218691688 7139520 complement(3975915..3976685) 1 NC_011745.1 Shows carboxylesterase activity with a preference for short chain fatty acid esters; involved in pimeloyl-CoA synthesis; carboxylesterase BioH 3976685 bioH 7139520 bioH Escherichia coli ED1a carboxylesterase BioH YP_002399900.1 3975915 R 585397 CDS YP_002399901.1 218691689 7140455 3976723..3977406 1 NC_011745.1 involved in high-affinity gluconate transport; gluconate periplasmic binding protein 3977406 gntX 7140455 gntX Escherichia coli ED1a gluconate periplasmic binding protein YP_002399901.1 3976723 D 585397 CDS YP_002399902.1 218691690 7143005 3977465..3978040 1 NC_011745.1 cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source; putative DNA uptake protein 3978040 gntY 7143005 gntY Escherichia coli ED1a putative DNA uptake protein YP_002399902.1 3977465 D 585397 CDS YP_002399903.1 218691691 7143006 3978404..3979720 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 172599, 4574689, 4582156, 93139975, 97141270, 98019089, 2845225, 3040894, 7984428, 9045817; Product type t : transporter; gluconate transporter, high-affinity GNT I system 3979720 gntT 7143006 gntT Escherichia coli ED1a gluconate transporter, high-affinity GNT I system YP_002399903.1 3978404 D 585397 CDS YP_002399904.1 218691692 7143003 complement(3979786..3981870) 1 NC_011745.1 amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase 3981870 malQ 7143003 malQ Escherichia coli ED1a 4-alpha-glucanotransferase YP_002399904.1 3979786 R 585397 CDS YP_002399905.1 218691693 7142201 complement(3981880..3984273) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89033892, 10220320, 10469642, 2845225, 3037809, 3155826, 6283313, 6339728, 6986282, 9009262; Product type e : enzyme; maltodextrin phosphorylase 3984273 malP 7142201 malP Escherichia coli ED1a maltodextrin phosphorylase YP_002399905.1 3981880 R 585397 CDS YP_002399906.1 218691694 7142200 3984896..3987601 1 NC_011745.1 Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides; transcriptional regulator MalT 3987601 malT 7142200 malT Escherichia coli ED1a transcriptional regulator MalT YP_002399906.1 3984896 D 585397 CDS YP_002399907.1 218691695 7142203 complement(3987644..3988660) 1 NC_011745.1 catalyzes the conversion of terminal3'-phosphate of RNA to the 2',3'-cyclicphosphodiester; RNA 3'-terminal-phosphate cyclase 3988660 rtcA 7142203 rtcA Escherichia coli ED1a RNA 3'-terminal-phosphate cyclase YP_002399907.1 3987644 R 585397 CDS YP_002399908.1 218691696 7140130 complement(3988664..3989890) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9738023; hypothetical protein 3989890 rtcB 7140130 rtcB Escherichia coli ED1a hypothetical protein YP_002399908.1 3988664 R 585397 CDS YP_002399909.1 218691697 7140131 3990079..3991677 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9738023, 3045764, 7920643, 7984428; Product type r : regulator; sigma 54-dependent transcriptional regulator of rtcBA expression 3991677 rtcR 7140131 rtcR Escherichia coli ED1a sigma 54-dependent transcriptional regulator of rtcBA expression YP_002399909.1 3990079 D 585397 CDS YP_002399910.1 218691698 7140132 complement(3991659..3992417) 1 NC_011745.1 represses the glpD, glpFK, glpTQ, and glpACB operons involved in glycerol-3-phosphate metabolism; DNA-binding transcriptional repressor GlpR 3992417 glpR 7140132 glpR Escherichia coli ED1a DNA-binding transcriptional repressor GlpR YP_002399910.1 3991659 R 585397 CDS YP_002399911.1 218691699 7142975 complement(3992434..3993264) 1 NC_011745.1 protease responsible for the cleavage between Ser and Asp residues of proteins in regions of high local hydrophilicity; intramembrane serine protease GlpG 3993264 glpG 7142975 glpG Escherichia coli ED1a intramembrane serine protease GlpG YP_002399911.1 3992434 R 585397 CDS YP_002399912.1 218691700 7142972 complement(3993309..3993635) 1 NC_011745.1 belongs to rhodanese family; thiosulfate thiotransferase; in Escherichia coli this enzyme catalyzes the formation of thiocyanate from thiosulfate and cyanide with low efficiency; contains an active site cysteine; thiosulfate sulfurtransferase 3993635 glpE 7142972 glpE Escherichia coli ED1a thiosulfate sulfurtransferase YP_002399912.1 3993309 R 585397 CDS YP_002399913.1 218691701 7142970 3993825..3995330 1 NC_011745.1 in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane; glycerol-3-phosphate dehydrogenase 3995330 glpD 7142970 glpD Escherichia coli ED1a glycerol-3-phosphate dehydrogenase YP_002399913.1 3993825 D 585397 CDS YP_002399914.1 218691702 7142969 complement(3995384..3995989) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3995989 7142969 ECED1_4087 Escherichia coli ED1a hypothetical protein YP_002399914.1 3995384 R 585397 CDS YP_002399915.1 218691703 7142306 complement(3995992..3996759) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3996759 7142306 ECED1_4088 Escherichia coli ED1a hypothetical protein YP_002399915.1 3995992 R 585397 CDS YP_002399916.1 218691704 7142307 complement(3996762..3997472) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3997472 7142307 ECED1_4089 Escherichia coli ED1a hypothetical protein YP_002399916.1 3996762 R 585397 CDS YP_002399917.1 218691705 7142308 complement(3997646..3998776) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15213132; Product type ps : putative structure; putative fimbrial-like adhesin protein AufG 3998776 aufG 7142308 aufG Escherichia coli ED1a putative fimbrial-like adhesin protein AufG YP_002399917.1 3997646 R 585397 CDS YP_002399918.1 218691706 7140423 complement(3998848..3999351) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF2, IS1 3999351 insB 7140423 insB Escherichia coli ED1a transposase ORF2, IS1 YP_002399918.1 3998848 R 585397 CDS YP_002399919.1 218691707 7141152 complement(3999270..3999545) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF 1, IS1 3999545 insA 7141152 insA Escherichia coli ED1a transposase ORF 1, IS1 YP_002399919.1 3999270 R 585397 CDS YP_002399920.1 218691708 7141129 complement(3999574..4000368) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15213132; Product type pf : putative factor; putative fimbrial chaperone AufF 4000368 aufF 7141129 aufF Escherichia coli ED1a putative fimbrial chaperone AufF YP_002399920.1 3999574 R 585397 CDS YP_002399921.1 218691709 7140422 complement(4000313..4000891) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15213132; Product type ps : putative structure; putative minor fimbrial subunit AufE 4000891 aufE 7140422 aufE Escherichia coli ED1a putative minor fimbrial subunit AufE YP_002399921.1 4000313 R 585397 CDS YP_002399922.1 218691710 7140421 complement(4000836..4001432) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative minor fimbrial subunit AufD 4001432 aufD 7140421 aufD Escherichia coli ED1a putative minor fimbrial subunit AufD YP_002399922.1 4000836 R 585397 CDS YP_002399923.1 218691711 7140420 4001474..4001749 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF 1, IS1 4001749 insA 7140420 insA Escherichia coli ED1a transposase ORF 1, IS1 YP_002399923.1 4001474 D 585397 CDS YP_002399924.1 218691712 7141130 4001668..4002171 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF2, IS1 4002171 insB 7141130 insB Escherichia coli ED1a transposase ORF2, IS1 YP_002399924.1 4001668 D 585397 CDS YP_002399925.1 218691713 7141153 complement(4002182..4004308) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15213132; Product type pf : putative factor; putative outer membrane export usher protein AufC 4004308 aufC 7141153 aufC Escherichia coli ED1a putative outer membrane export usher protein AufC YP_002399925.1 4002182 R 585397 CDS YP_002399926.1 218691714 7140419 complement(4004345..4005124) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15213132; Product type pf : putative factor; putative fimbrial chaperone AufB 4005124 aufB 7140419 aufB Escherichia coli ED1a putative fimbrial chaperone AufB YP_002399926.1 4004345 R 585397 CDS YP_002399927.1 218691715 7140417 4006136..4006411 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF 1, IS1 4006411 7140417 ECED1_4101 Escherichia coli ED1a transposase ORF 1, IS1 YP_002399927.1 4006136 D 585397 CDS YP_002399928.1 218691716 7142309 4006330..4006833 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF2, IS1 4006833 insB 7142309 insB Escherichia coli ED1a transposase ORF2, IS1 YP_002399928.1 4006330 D 585397 CDS YP_002399929.1 218691717 7141154 complement(4007172..4009619) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88330897, 91104907, 91236706, 2645169, 2975249, 3047129, 3097003; Product type e : enzyme; glycogen phosphorylase 4009619 glgP 7141154 glgP Escherichia coli ED1a glycogen phosphorylase YP_002399929.1 4007172 R 585397 CDS YP_002399930.1 218691718 7143188 complement(4009638..4011071) 1 NC_011745.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 4011071 glgA 7143188 glgA Escherichia coli ED1a glycogen synthase YP_002399930.1 4009638 R 585397 CDS YP_002399931.1 218691719 7143185 complement(4011071..4012366) 1 NC_011745.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 4012366 glgC 7143185 glgC Escherichia coli ED1a glucose-1-phosphate adenylyltransferase YP_002399931.1 4011071 R 585397 CDS YP_002399932.1 218691720 7143187 complement(4012384..4014357) 1 NC_011745.1 catalyzes the hydrolysis of the alpha-1,6-glucosidic linkages in partially depolymerized glycogen; glycogen debranching enzyme 4014357 glgX 7143187 glgX Escherichia coli ED1a glycogen debranching enzyme YP_002399932.1 4012384 R 585397 CDS YP_002399933.1 218691721 7143190 complement(4014354..4016540) 1 NC_011745.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching enzyme 4016540 glgB 7143190 glgB Escherichia coli ED1a glycogen branching enzyme YP_002399933.1 4014354 R 585397 CDS YP_002399934.1 218691722 7143186 complement(4016813..4017916) 1 NC_011745.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 4017916 asd 7143186 asd Escherichia coli ED1a aspartate-semialdehyde dehydrogenase YP_002399934.1 4016813 R 585397 CDS YP_002399935.1 218691723 7142641 4018108..4018701 1 NC_011745.1 YhgN; Ec0197; hydrolyzes nucleoside triphosphates with an O6 atom-containing purine base to nucleoside monophosphate and pyrophosphate; seems to play a role in the elimination of aberrant purine-derived nucleotides containing the 6-keto group; shows preference for deoxyinosine triphosphate and xanthosine triphosphate over standard nucleoside triphosphates (dATP, dCTP, dGTP, and dTTP); putative dITP- and XTP- hydrolase 4018701 yhgN 7142641 yhgN Escherichia coli ED1a putative dITP- and XTP- hydrolase YP_002399935.1 4018108 D 585397 CDS YP_002399936.1 218691724 7139524 complement(4018758..4020098) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8655507, 9119199, 9135111, 97141270; Product type t : transporter; low affinity gluconate transporter 4020098 gntU 7139524 gntU Escherichia coli ED1a low affinity gluconate transporter YP_002399936.1 4018758 R 585397 CDS YP_002399937.1 218691725 7143004 complement(4020102..4020629) 1 NC_011745.1 thermoresistant; catalyzes the formation of 6-phospho-D-gluconate from gluconate; gluconate kinase 1 4020629 gntK 7143004 gntK Escherichia coli ED1a gluconate kinase 1 YP_002399937.1 4020102 R 585397 CDS YP_002399938.1 218691726 7143000 complement(4020768..4021763) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 172599, 9135111, 93139975, 9537375, 8655507; Product type r : regulator; DNA-binding transcriptional repressor 4021763 gntR 7143000 gntR Escherichia coli ED1a DNA-binding transcriptional repressor YP_002399938.1 4020768 R 585397 CDS YP_002399939.1 218691727 7143002 complement(4021856..4022551) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4022551 yhhW 7143002 yhhW Escherichia coli ED1a hypothetical protein YP_002399939.1 4021856 R 585397 CDS YP_002399940.1 218691728 7139535 complement(4022674..4023711) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10493123; Product type pe : putative enzyme; putative dehydrogenase 4023711 yhhX 7139535 yhhX Escherichia coli ED1a putative dehydrogenase YP_002399940.1 4022674 R 585397 CDS YP_002399941.1 218691729 7141352 4024046..4024534 1 NC_011745.1 YhhY; regulated by the fur regulator; unknown function; putative acetyltransferase YhhY 4024534 yhhY 7141352 yhhY Escherichia coli ED1a putative acetyltransferase YhhY YP_002399941.1 4024046 D 585397 CDS YP_002399942.1 218691730 7139539 4025946..4026440 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4026440 yrhA 7139539 yrhA Escherichia coli ED1a hypothetical protein YP_002399942.1 4025946 D 585397 CDS YP_002399943.1 218691731 7143251 4026890..4027174 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4027174 yrhB 7143251 yrhB Escherichia coli ED1a hypothetical protein YP_002399943.1 4026890 D 585397 CDS YP_002399944.1 218691732 7143252 complement(4027212..4028972) 1 NC_011745.1 periplasmic enzyme; post-translationally processed into two subunits which are required for wild-type enzyme activity; cleaves the gammaglutamyl linkages of compounds such as glutathione and transfer the gammaglutamyl group to other amino acids and peptides; gamma-glutamyltranspeptidase 4028972 ggt 7143252 ggt Escherichia coli ED1a gamma-glutamyltranspeptidase YP_002399944.1 4027212 R 585397 CDS YP_002399945.1 218691733 7143175 4029065..4029505 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4029505 yhhA 7143175 yhhA Escherichia coli ED1a hypothetical protein YP_002399945.1 4029065 D 585397 CDS YP_002399946.1 218691734 7139525 complement(4029492..4030235) 1 NC_011745.1 hydrolyzes diesters during transport at the inner face of the cytoplasmic membrane to glycerol-3-phosphate and alcohol; induced when cells are starved for inorganic phosphate; cytoplasmic glycerophosphodiester phosphodiesterase 4030235 ugpQ 7139525 ugpQ Escherichia coli ED1a cytoplasmic glycerophosphodiester phosphodiesterase YP_002399946.1 4029492 R 585397 CDS YP_002399947.1 218691735 7138877 complement(4030232..4031302) 1 NC_011745.1 part of the UgpABCE glycerol-3-phosphate uptake system; glycerol-3-phosphate transporter ATP-binding subunit 4031302 ugpC 7138877 ugpC Escherichia coli ED1a glycerol-3-phosphate transporter ATP-binding subunit YP_002399947.1 4030232 R 585397 CDS YP_002399948.1 218691736 7138874 complement(4031304..4032149) 1 NC_011745.1 with UgpABC is involved in uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter membrane protein 4032149 ugpE 7138874 ugpE Escherichia coli ED1a glycerol-3-phosphate transporter membrane protein YP_002399948.1 4031304 R 585397 CDS YP_002399949.1 218691737 7138876 complement(4032146..4033033) 1 NC_011745.1 with UgpEC is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter permease 4033033 ugpA 7138876 ugpA Escherichia coli ED1a glycerol-3-phosphate transporter permease YP_002399949.1 4032146 R 585397 CDS YP_002399950.1 218691738 7140869 complement(4033131..4034447) 1 NC_011745.1 with UgpACE is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter periplasmic binding protein 4034447 ugpB 7140869 ugpB Escherichia coli ED1a glycerol-3-phosphate transporter periplasmic binding protein YP_002399950.1 4033131 R 585397 CDS YP_002399951.1 218691739 7140870 complement(4034844..4035557) 1 NC_011745.1 with LivGHMJ and LivGHMK is part of the high-affinity branched-chain amino acid transport system; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding subunit 4035557 livF 7140870 livF Escherichia coli ED1a leucine/isoleucine/valine transporter ATP-binding subunit YP_002399951.1 4034844 R 585397 CDS YP_002399952.1 218691740 7141890 complement(4035559..4036326) 1 NC_011745.1 Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding subunit 4036326 livG 7141890 livG Escherichia coli ED1a leucine/isoleucine/valine transporter ATP-binding subunit YP_002399952.1 4035559 R 585397 CDS YP_002399953.1 218691741 7141891 complement(4036323..4037600) 1 NC_011745.1 Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter permease subunit 4037600 livM 7141891 livM Escherichia coli ED1a leucine/isoleucine/valine transporter permease subunit YP_002399953.1 4036323 R 585397 CDS YP_002399954.1 218691742 7141895 complement(4037597..4038523) 1 NC_011745.1 LivHMGF is the membrane component of the LIV-I/LS branched-chain amino acid transporter; branched-chain amino acid transporter permease subunit LivH 4038523 livH 7141895 livH Escherichia coli ED1a branched-chain amino acid transporter permease subunit LivH YP_002399954.1 4037597 R 585397 CDS YP_002399955.1 218691743 7141892 complement(4038571..4039680) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14702302, 90307651, 2195019, 2649683, 3891753, 4077929, 9298646, 9298646; Product type t : transporter; leucine ABC transporter subunit periplasmic-binding protein 4039680 livK 7141892 livK Escherichia coli ED1a leucine ABC transporter subunit periplasmic-binding protein YP_002399955.1 4038571 R 585397 CDS YP_002399956.1 218691744 7141894 4040104..4040487 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4040487 yhhK 7141894 yhhK Escherichia coli ED1a hypothetical protein YP_002399956.1 4040104 D 585397 CDS YP_002399957.1 218691745 7139528 complement(4040675..4041778) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14702302, 90307651, 2195019, 2649682, 328304, 3891753, 4077929, 9298646, 10972807; Product type t : transporter; leucine/isoleucine/valine ABC transporter subunit periplasmic-binding protein 4041778 livJ 7139528 livJ Escherichia coli ED1a leucine/isoleucine/valine ABC transporter subunit periplasmic-binding protein YP_002399957.1 4040675 R 585397 CDS YP_002399958.1 218691746 7141893 complement(4042049..4042903) 1 NC_011745.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 4042903 rpoH 7141893 rpoH Escherichia coli ED1a RNA polymerase factor sigma-32 YP_002399958.1 4042049 R 585397 CDS YP_002399959.1 218691747 7141489 complement(4043148..4044206) 1 NC_011745.1 putative ABC transporter, membrane protein; cell division protein FtsX 4044206 ftsX 7141489 ftsX Escherichia coli ED1a cell division protein FtsX YP_002399959.1 4043148 R 585397 CDS YP_002399960.1 218691748 7143121 complement(4044199..4044867) 1 NC_011745.1 putative ATP-binding protein of an ATP-binding cassette transporter; when bound to FtsX, FtsEX localizes to the cell division site and plays a role in the assembly or stability of the septal ring under low-salt growth conditions; cell division protein FtsE 4044867 ftsE 7143121 ftsE Escherichia coli ED1a cell division protein FtsE YP_002399960.1 4044199 R 585397 CDS YP_002399961.1 218691749 7142190 complement(4044870..4046366) 1 NC_011745.1 signal recognition protein receptor; functions in the targeting and insertion of membrane proteins; cell division protein FtsY 4046366 ftsY 7142190 ftsY Escherichia coli ED1a cell division protein FtsY YP_002399961.1 4044870 R 585397 CDS YP_002399962.1 218691750 7143122 4046516..4047112 1 NC_011745.1 catalyzes the methylation of 16S rRNA at position G966; 16S rRNA m(2)G966-methyltransferase 4047112 rsmD 7143122 rsmD Escherichia coli ED1a 16S rRNA m(2)G966-methyltransferase YP_002399962.1 4046516 D 585397 CDS YP_002399963.1 218691751 7139526 4047102..4047371 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4047371 yhhL 7139526 yhhL Escherichia coli ED1a hypothetical protein YP_002399963.1 4047102 D 585397 CDS YP_002399964.1 218691752 7139529 complement(4047374..4047733) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4047733 yhhM 7139529 yhhM Escherichia coli ED1a hypothetical protein YP_002399964.1 4047374 R 585397 CDS YP_002399965.1 218691753 7139530 4047874..4048500 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4048500 yhhN 7139530 yhhN Escherichia coli ED1a hypothetical protein YP_002399965.1 4047874 D 585397 CDS YP_002399966.1 218691754 7139531 4048574..4050772 1 NC_011745.1 P-type ATPase involved in the export of lead, cadmium, zinc and mercury; zinc/cadmium/mercury/lead-transporting ATPase 4050772 zntA 7139531 zntA Escherichia coli ED1a zinc/cadmium/mercury/lead-transporting ATPase YP_002399966.1 4048574 D 585397 CDS YP_002399967.1 218691755 7143276 complement(4051041..4051286) 1 NC_011745.1 TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein SirA 4051286 tusA 7143276 tusA Escherichia coli ED1a sulfur transfer protein SirA YP_002399967.1 4051041 R 585397 CDS YP_002399968.1 218691756 7140845 4051507..4052172 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4052172 yhhQ 7140845 yhhQ Escherichia coli ED1a hypothetical protein YP_002399968.1 4051507 D 585397 CDS YP_002399969.1 218691757 7139532 4052245..4052802 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12558182, 8752353; Product type t : transporter; hypothetical protein 4052802 dcrB 7139532 dcrB Escherichia coli ED1a hypothetical protein YP_002399969.1 4052245 D 585397 CDS YP_002399970.1 218691758 7143071 complement(4052806..4054023) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; major facilitator superfamily transporter 4054023 yhhS 7143071 yhhS Escherichia coli ED1a major facilitator superfamily transporter YP_002399970.1 4052806 R 585397 CDS YP_002399971.1 218691759 7139533 4054155..4055204 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4055204 yhhT 7139533 yhhT Escherichia coli ED1a hypothetical protein YP_002399971.1 4054155 D 585397 CDS YP_002399972.1 218691760 7139534 4055259..4055846 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20092861, 10625633, 8939709; Product type e : enzyme; holo-(acyl carrier protein) synthase 2 4055846 acpT 7139534 acpT Escherichia coli ED1a holo-(acyl carrier protein) synthase 2 YP_002399972.1 4055259 D 585397 CDS YP_002399973.1 218691761 7143648 4055957..4057531 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12960164, 7934931, 92077434, 7867647; Product type t : transporter; nickel ABC transporter subunit periplasmic-binding protein 4057531 nikA 7143648 nikA Escherichia coli ED1a nickel ABC transporter subunit periplasmic-binding protein YP_002399973.1 4055957 D 585397 CDS YP_002399974.1 218691762 7140386 4057531..4058475 1 NC_011745.1 with NikACDE is involved in nickel transport into the cell; nickel transporter permease NikB 4058475 nikB 7140386 nikB Escherichia coli ED1a nickel transporter permease NikB YP_002399974.1 4057531 D 585397 CDS YP_002399975.1 218691763 7140387 4058472..4059305 1 NC_011745.1 with NikABDE is involved in nickel transport into the cell; nickel transporter permease NikC 4059305 nikC 7140387 nikC Escherichia coli ED1a nickel transporter permease NikC YP_002399975.1 4058472 D 585397 CDS YP_002399976.1 218691764 7140388 4059305..4060069 1 NC_011745.1 with NikABCE is involved in nickel transport into the cell; nickel transporter ATP-binding protein NikD 4060069 nikD 7140388 nikD Escherichia coli ED1a nickel transporter ATP-binding protein NikD YP_002399976.1 4059305 D 585397 CDS YP_002399977.1 218691765 7140389 4060066..4060872 1 NC_011745.1 with NikABCD is involved with nickel transport into the cell; nickel transporter ATP-binding protein NikE 4060872 nikE 7140389 nikE Escherichia coli ED1a nickel transporter ATP-binding protein NikE YP_002399977.1 4060066 D 585397 CDS YP_002399978.1 218691766 7140390 4060878..4061279 1 NC_011745.1 Inhibits transcription at high concentrations of nickel; nickel responsive regulator 4061279 nikR 7140390 nikR Escherichia coli ED1a nickel responsive regulator YP_002399978.1 4060878 D 585397 CDS YP_002399979.1 218691767 7140391 complement(4061288..4062412) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter membrane protein 4062412 yhhJ 7140391 yhhJ Escherichia coli ED1a putative ABC transporter membrane protein YP_002399979.1 4061288 R 585397 CDS YP_002399980.1 218691768 7139527 complement(4062412..4065147) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20074572; Product type e : enzyme; fused ribosome-associated ATPase: ATP-binding protein ; ATP-binding protein ; putative membrane protein 4065147 rbbA 7139527 rbbA Escherichia coli ED1a fused ribosome-associated ATPase: ATP-binding protein ; ATP-binding protein ; putative membrane protein YP_002399980.1 4062412 R 585397 CDS YP_002399981.1 218691769 7141253 complement(4065144..4066211) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative HlyD family secretion protein 4066211 yhiI 7141253 yhiI Escherichia coli ED1a putative HlyD family secretion protein YP_002399981.1 4065144 R 585397 CDS YP_002399982.1 218691770 7139542 4066933..4067997 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4067997 yhiM 7139542 yhiM Escherichia coli ED1a hypothetical protein YP_002399982.1 4066933 D 585397 CDS YP_002399983.1 218691771 7139543 complement(4068084..4069277) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase with FAD/NAD(P)-binding domain 4069277 yhiN 7139543 yhiN Escherichia coli ED1a putative oxidoreductase with FAD/NAD(P)-binding domain YP_002399983.1 4068084 R 585397 CDS YP_002399984.1 218691772 7139544 4069509..4071008 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87014120; Product type t : transporter; phosphate transporter, low-affinity 4071008 pitA 7139544 pitA Escherichia coli ED1a phosphate transporter, low-affinity YP_002399984.1 4069509 D 585397 CDS YP_002399985.1 218691773 7139065 complement(4071079..4071414) 1 NC_011745.1 ppGpp-dependent, membrane associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress; universal stress protein UspB 4071414 yhiO 7139065 yhiO Escherichia coli ED1a universal stress protein UspB YP_002399985.1 4071079 R 585397 CDS YP_002399986.1 218691774 7139545 4071805..4072239 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12732303, 93086426, 93308072, 94203056, 10499297, 10652104, 10931298, 11157932, 1453957, 8506346, 8932299, 9298646, 9405142; Product type f : factor; universal stress global response regulator 4072239 uspA 7139545 uspA Escherichia coli ED1a universal stress global response regulator YP_002399986.1 4071805 D 585397 CDS YP_002399987.1 218691775 7139145 4072556..4074025 1 NC_011745.1 member of the POT family of peptide transporters; probable proton-dependent peptide transporter function; inner membrane transporter YhiP 4074025 yhiP 7139145 yhiP Escherichia coli ED1a inner membrane transporter YhiP YP_002399987.1 4072556 D 585397 CDS YP_002399988.1 218691776 7139546 complement(4074074..4074826) 1 NC_011745.1 predicted SAM-dependent methyltransferase; putative methyltransferase 4074826 yhiQ 7139546 yhiQ Escherichia coli ED1a putative methyltransferase YP_002399988.1 4074074 R 585397 CDS YP_002399989.1 218691777 7139593 complement(4074834..4076876) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92394891, 1325967, 8366062; Product type e : enzyme; oligopeptidase A 4076876 prlC 7139593 prlC Escherichia coli ED1a oligopeptidase A YP_002399989.1 4074834 R 585397 CDS YP_002399990.1 218691778 7139123 4077079..4077921 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11591672; Product type pe : putative enzyme; putative DNA (exogenous) processing protein 4077921 yhiR 7139123 yhiR Escherichia coli ED1a putative DNA (exogenous) processing protein YP_002399990.1 4077079 D 585397 CDS YP_002399991.1 218691779 7139674 4077993..4079345 1 NC_011745.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 4079345 gor 7139674 gor Escherichia coli ED1a glutathione reductase YP_002399991.1 4077993 D 585397 CDS YP_002399992.1 218691780 7143007 complement(4079399..4079548) 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 4079548 7143007 ECED1_4170 Escherichia coli ED1a hypothetical protein YP_002399992.1 4079399 R 585397 CDS YP_002399993.1 218691781 7142310 4079504..4079725 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 4079725 7142310 ECED1_4171 Escherichia coli ED1a hypothetical protein YP_002399993.1 4079504 D 585397 CDS YP_002399994.1 218691782 7142311 4079817..4080242 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95355341, 7721697; Product type e : enzyme; arsenate reductase 4080242 arsC 7142311 arsC Escherichia coli ED1a arsenate reductase YP_002399994.1 4079817 D 585397 CDS YP_002399995.1 218691783 7139675 4081429..4081995 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94293775, 8022277; Product type lp : lipoprotein; outer membrane lipoprotein 4081995 slp 7139675 slp Escherichia coli ED1a outer membrane lipoprotein YP_002399995.1 4081429 D 585397 CDS YP_002399996.1 218691784 7143803 4082148..4082678 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8022277; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 4082678 yhiF 7143803 yhiF Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002399996.1 4082148 D 585397 CDS YP_002399997.1 218691785 7139541 complement(4082735..4083763) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16275907; Product type e : enzyme; Heme oxygenase 4083763 chuS 7139541 chuS Escherichia coli ED1a Heme oxygenase YP_002399997.1 4082735 R 585397 CDS YP_002399998.1 218691786 7139348 4086400..4087392 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7768795, 9393841, 9680204; Product type pt : putative transporter; putative periplasmic binding protein 4087392 chuT 7139348 chuT Escherichia coli ED1a putative periplasmic binding protein YP_002399998.1 4086400 D 585397 CDS YP_002399999.1 218691787 7139350 4087412..4088749 1 NC_011745.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 4088749 7139350 ECED1_4181 Escherichia coli ED1a coproporphyrinogen III oxidase YP_002399999.1 4087412 D 585397 CDS YP_002400000.1 218691788 7142312 4088762..4089256 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4089256 7142312 ECED1_4182 Escherichia coli ED1a hypothetical protein YP_002400000.1 4088762 D 585397 CDS YP_002400001.1 218691789 7142313 4089256..4089879 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4089879 7142313 ECED1_4183 Escherichia coli ED1a hypothetical protein YP_002400001.1 4089256 D 585397 CDS YP_002400002.1 218691790 7142314 4089928..4090920 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative hemin transport system permease 4090920 chuU 7142314 chuU Escherichia coli ED1a putative hemin transport system permease YP_002400002.1 4089928 D 585397 CDS YP_002400003.1 218691791 7139351 4090917..4091687 1 NC_011745.1 with HmuTU is involved in the transport of hemin; hemin importer ATP-binding subunit 4091687 hmuV 7139351 hmuV Escherichia coli ED1a hemin importer ATP-binding subunit YP_002400003.1 4090917 D 585397 CDS YP_002400004.1 218691792 7139352 complement(4091739..4092386) 1 NC_011745.1 inner membrane protein involved in cell density-dependent acid resistance; part of the acid fitness island (AFI) of E. coli; putative Mg(2+) transport ATPase 4092386 yhiD 7139352 yhiD Escherichia coli ED1a putative Mg(2+) transport ATPase YP_002400004.1 4091739 R 585397 CDS YP_002400005.1 218691793 7139540 complement(4092450..4092776) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94064579, 8885264, 12071744, 8244952, 8455549, 9298646, 9868784; Product type pf : putative factor; acid-resistance protein 4092776 hdeB 7139540 hdeB Escherichia coli ED1a acid-resistance protein YP_002400005.1 4092450 R 585397 CDS YP_002400006.1 218691794 7139860 complement(4092892..4093224) 1 NC_011745.1 inactive form; acid-resistance protein 4093224 hdeA 7139860 hdeA Escherichia coli ED1a acid-resistance protein YP_002400006.1 4092892 R 585397 CDS YP_002400007.1 218691795 7139859 4093479..4094051 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94064579, 8244952, 8455549; Product type pm : putative membrane component; acid-resistance membrane protein 4094051 hdeD 7139859 hdeD Escherichia coli ED1a acid-resistance membrane protein YP_002400007.1 4093479 D 585397 CDS YP_002400008.1 218691796 7139861 4094850..4095377 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12399493, 12940989, 14702398; Product type r : regulator; DNA-binding transcriptional activator 4095377 gadE 7139861 gadE Escherichia coli ED1a DNA-binding transcriptional activator YP_002400008.1 4094850 D 585397 CDS YP_002400009.1 218691797 7143144 4095716..4096873 1 NC_011745.1 with MdtF and tolC is involved in resistance to rhodamine 6G, erythromycin, doxorubicin and other compounds; multidrug efflux system protein MdtE 4096873 mdtE 7143144 mdtE Escherichia coli ED1a multidrug efflux system protein MdtE YP_002400009.1 4095716 D 585397 CDS YP_002400010.1 218691798 7142231 4096898..4100011 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21450803; Product type t : transporter; multidrug transporter, RpoS-dependent 4100011 mdtF 7142231 mdtF Escherichia coli ED1a multidrug transporter, RpoS-dependent YP_002400010.1 4096898 D 585397 CDS YP_002400011.1 218691799 7142232 complement(4100374..4101102) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12446650; Product type r : regulator; DNA-binding transcriptional activator 4101102 gadW 7142232 gadW Escherichia coli ED1a DNA-binding transcriptional activator YP_002400011.1 4100374 R 585397 CDS YP_002400012.1 218691800 7143147 complement(4101471..4102295) 1 NC_011745.1 regulates genes in response to acid and/or during stationary phase; DNA-binding transcriptional regulator GadX 4102295 gadX 7143147 gadX Escherichia coli ED1a DNA-binding transcriptional regulator GadX YP_002400012.1 4101471 R 585397 CDS YP_002400013.1 218691801 7143146 complement(4102664..4104064) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92155241, 92394884, 99406302, 1522060, 1740158, 7764225, 9298646; Product type e : enzyme; glutamate decarboxylase A, PLP-dependent 4104064 gadA 7143146 gadA Escherichia coli ED1a glutamate decarboxylase A, PLP-dependent YP_002400013.1 4102664 R 585397 CDS YP_002400014.1 218691802 7143141 complement(4104275..4105672) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8163487, 14563563; Product type e : enzyme; cytochrome C peroxidase (cpp-like) 4105672 yhjA 7143141 yhjA Escherichia coli ED1a cytochrome C peroxidase (cpp-like) YP_002400014.1 4104275 R 585397 CDS YP_002400015.1 218691803 7139676 4106077..4107726 1 NC_011745.1 cytoplasmic; catalyzes the hydrolysis of trehalose to glucose; trehalase 4107726 treF 7139676 treF Escherichia coli ED1a trehalase YP_002400015.1 4106077 D 585397 CDS YP_002400016.1 218691804 7140807 complement(4107777..4108379) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding response regulator in two-component regulatory system 4108379 yhjB 7140807 yhjB Escherichia coli ED1a putative DNA-binding response regulator in two-component regulatory system YP_002400016.1 4107777 R 585397 CDS YP_002400017.1 218691805 7139677 4108827..4109798 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 4109798 yhjC 7139677 yhjC Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002400017.1 4108827 D 585397 CDS YP_002400018.1 218691806 7139678 4109847..4110860 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4110860 yhjD 7139678 yhjD Escherichia coli ED1a hypothetical protein YP_002400018.1 4109847 D 585397 CDS YP_002400019.1 218691807 7139679 4111253..4112575 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 4112575 yhjE 7139679 yhjE Escherichia coli ED1a putative transporter YP_002400019.1 4111253 D 585397 CDS YP_002400020.1 218691808 7139680 complement(4112616..4114691) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative outer membrane biogenesis protein 4114691 yhjG 7139680 yhjG Escherichia coli ED1a putative outer membrane biogenesis protein YP_002400020.1 4112616 R 585397 CDS YP_002400021.1 218691809 7139681 complement(4114746..4115513) 1 NC_011745.1 in Escherichia coli this protein is involved in flagellar function; EAL domain-containing protein 4115513 yhjH 7139681 yhjH Escherichia coli ED1a EAL domain-containing protein YP_002400021.1 4114746 R 585397 CDS YP_002400022.1 218691810 7139682 4115745..4116674 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 4359651, 13813474; Product type e : enzyme; ketodeoxygluconokinase 4116674 kdgK 7139682 kdgK Escherichia coli ED1a ketodeoxygluconokinase YP_002400022.1 4115745 D 585397 CDS YP_002400023.1 218691811 7142490 complement(4116770..4118266) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9298646; Product type pe : putative enzyme; putative zinc-dependent peptidase 4118266 yhjJ 7142490 yhjJ Escherichia coli ED1a putative zinc-dependent peptidase YP_002400023.1 4116770 R 585397 CDS YP_002400024.1 218691812 7139683 complement(4118486..4119772) 1 NC_011745.1 involved in the transport of C4-dicarboxylates across the membrane; C4-dicarboxylate transporter DctA 4119772 dctA 7139683 dctA Escherichia coli ED1a C4-dicarboxylate transporter DctA YP_002400024.1 4118486 R 585397 CDS YP_002400025.1 218691813 7143072 complement(4119955..4121904) 1 NC_011745.1 HmsP in Yersinia pestis plays a role in invasion of epithelial cells; the EAL-domain portion of HmsP from Y. pestis shows phosphodiesterase activity which is required for the inhibition of biofilm formation; inner membrane protein; similar to a putative phosphodiesterase protein from E. coli; putative phosphodiesterase 4121904 yhjK 7143072 yhjK Escherichia coli ED1a putative phosphodiesterase YP_002400025.1 4119955 R 585397 CDS YP_002400026.1 218691814 7139684 complement(4122026..4125499) 1 NC_011745.1 cellulose is produced by the multicellular morphotypes of E. coli and Salmonella typhimurium; the cellulose biosynthesis genes bcsA, bcsB, bcsZ and bcsC are constitutively transcribed, however, cellulose synthesis is dependent on the expression of adrA; cellulose synthase subunit BcsC 4125499 bcsC 7139684 bcsC Escherichia coli ED1a cellulose synthase subunit BcsC YP_002400026.1 4122026 R 585397 CDS YP_002400027.1 218691815 7140437 complement(4125481..4126587) 1 NC_011745.1 catalyzes the hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; endo-1,4-D-glucanase 4126587 bcsZ 7140437 bcsZ Escherichia coli ED1a endo-1,4-D-glucanase YP_002400027.1 4125481 R 585397 CDS YP_002400028.1 218691816 7140441 complement(4126594..4128933) 1 NC_011745.1 binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP); cellulose synthase regulator protein 4128933 bcsB 7140441 bcsB Escherichia coli ED1a cellulose synthase regulator protein YP_002400028.1 4126594 R 585397 CDS YP_002400029.1 218691817 7140436 complement(4128944..4131562) 1 NC_011745.1 polymerizes uridine 5'-diphosphate glucose to cellulose; acts with BcsB, BcsZ and BcsC in cellulose biosynthesis; cellulose synthase catalytic subunit 4131562 bcsA 7140436 bcsA Escherichia coli ED1a cellulose synthase catalytic subunit YP_002400029.1 4128944 R 585397 CDS YP_002400030.1 218691818 7140435 complement(4131673..4132311) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9054507; Product type pe : putative enzyme; putative chromosome partitioning ATPase 4132311 yhjQ 7140435 yhjQ Escherichia coli ED1a putative chromosome partitioning ATPase YP_002400030.1 4131673 R 585397 CDS YP_002400031.1 218691819 7139685 complement(4132323..4132511) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4132511 yhjR 7139685 yhjR Escherichia coli ED1a hypothetical protein YP_002400031.1 4132323 R 585397 CDS YP_002400032.1 218691820 7139686 4132784..4134355 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11929533, 11260463; Product type pe : putative enzyme; putative cellulose biosynthesis protease 4134355 bcsE 7139686 bcsE Escherichia coli ED1a putative cellulose biosynthesis protease YP_002400032.1 4132784 D 585397 CDS YP_002400033.1 218691821 7140438 4134352..4134543 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4134543 bcsF 7140438 bcsF Escherichia coli ED1a hypothetical protein YP_002400033.1 4134352 D 585397 CDS YP_002400034.1 218691822 7140439 4134540..4136219 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11929533, 11260463; Product type pe : putative enzyme; putative cellulose biosynthesis endoglucanase 4136219 bcsG 7140439 bcsG Escherichia coli ED1a putative cellulose biosynthesis endoglucanase YP_002400034.1 4134540 D 585397 CDS YP_002400035.1 218691823 7141573 complement(4136578..4136739) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4136739 7141573 ECED1_4217 Escherichia coli ED1a hypothetical protein YP_002400035.1 4136578 R 585397 CDS YP_002400036.1 218691824 7142315 4136889..4138160 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 15901718; Product type t : transporter; transporter 4138160 yhjV 7142315 yhjV Escherichia coli ED1a transporter YP_002400036.1 4136889 D 585397 CDS YP_002400037.1 218691825 7139687 complement(4138190..4139194) 1 NC_011745.1 Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides; dipeptide transporter ATP-binding subunit 4139194 dppF 7139687 dppF Escherichia coli ED1a dipeptide transporter ATP-binding subunit YP_002400037.1 4138190 R 585397 CDS YP_002400038.1 218691826 7140518 complement(4139191..4140174) 1 NC_011745.1 DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF; dipeptide transporter ATP-binding subunit 4140174 dppD 7140518 dppD Escherichia coli ED1a dipeptide transporter ATP-binding subunit YP_002400038.1 4139191 R 585397 CDS YP_002400039.1 218691827 7140517 complement(4140185..4141087) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7536291; Product type t : transporter; dipeptide transporter 4141087 dppC 7140517 dppC Escherichia coli ED1a dipeptide transporter YP_002400039.1 4140185 R 585397 CDS YP_002400040.1 218691828 7140516 complement(4141097..4142116) 1 NC_011745.1 transports peptides consisting of two or three amino acids; dipeptide transporter permease DppB 4142116 dppB 7140516 dppB Escherichia coli ED1a dipeptide transporter permease DppB YP_002400040.1 4141097 R 585397 CDS YP_002400041.1 218691829 7140515 complement(4142423..4144030) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91100289, 92065799, 1702779, 1956284, 7536291, 8527431, 8563629, 9298646, 9600841, 9740056, 10972807; Product type t : transporter; dipeptide ABC transporter periplasmic-binding 4144030 dppA 7140515 dppA Escherichia coli ED1a dipeptide ABC transporter periplasmic-binding YP_002400041.1 4142423 R 585397 CDS YP_002400042.1 218691830 7140606 complement(4144939..4146630) 1 NC_011745.1 catalyzes the addition of a phosphoethanolamine group to the outer Kdo residue of lipopolysaccharide; phosphoethanolamine transferase 4146630 eptB 7140606 eptB Escherichia coli ED1a phosphoethanolamine transferase YP_002400042.1 4144939 R 585397 CDS YP_002400043.1 218691831 7139808 complement(4146883..4147407) 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14977923; Product type pm : putative membrane component; LpfE protein 4147407 lpfE 7139808 lpfE Escherichia coli ED1a LpfE protein YP_002400043.1 4146883 R 585397 CDS YP_002400044.1 218691832 7141912 complement(4147413..4148297) 1 NC_011745.1 Evidence 7 : Gene remnant; Product type s : structure; putative minor fimbrial subunit (fragment) 4148297 7141912 ECED1_4226 Escherichia coli ED1a putative minor fimbrial subunit (fragment) YP_002400044.1 4147413 R 585397 CDS YP_002400045.1 218691833 7142316 4148372..4148875 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF2, IS1 4148875 insB 7142316 insB Escherichia coli ED1a transposase ORF2, IS1 YP_002400045.1 4148372 D 585397 CDS YP_002400046.1 218691834 7141155 complement(4148886..4149272) 1 NC_011745.1 Evidence 7 : Gene remnant; Product type s : structure; putative minor fimbrial subunit (fragment) 4149272 7141155 ECED1_4228 Escherichia coli ED1a putative minor fimbrial subunit (fragment) YP_002400046.1 4148886 R 585397 CDS YP_002400047.1 218691835 7142317 complement(4149253..4151784) 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14977923; Product type m : membrane component; outer membrane usher protein lpfC 4151784 lpfC 7142317 lpfC Escherichia coli ED1a outer membrane usher protein lpfC YP_002400047.1 4149253 R 585397 CDS YP_002400048.1 218691836 7141911 complement(4151807..4152493) 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14977923; Product type m : membrane component; Chaperone protein lpfB 4152493 lpfB 7141911 lpfB Escherichia coli ED1a Chaperone protein lpfB YP_002400048.1 4151807 R 585397 CDS YP_002400049.1 218691837 7141910 complement(4152577..4153101) 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14977923; Product type m : membrane component; Long polar fimbria protein A 4153101 lpfA 7141910 lpfA Escherichia coli ED1a Long polar fimbria protein A YP_002400049.1 4152577 R 585397 CDS YP_002400050.1 218691838 7141909 complement(4153425..4154672) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 4154672 yhjX 7141909 yhjX Escherichia coli ED1a putative transporter YP_002400050.1 4153425 R 585397 CDS YP_002400051.1 218691839 7139688 complement(4154856..4155554) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4155554 yhjY 7139688 yhjY Escherichia coli ED1a hypothetical protein YP_002400051.1 4154856 R 585397 CDS YP_002400052.1 218691840 7139689 4155712..4156275 1 NC_011745.1 constitutive, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine; 3-methyl-adenine DNA glycosylase I 4156275 tag 7139689 tag Escherichia coli ED1a 3-methyl-adenine DNA glycosylase I YP_002400052.1 4155712 D 585397 CDS YP_002400053.1 218691841 7141504 4156272..4156712 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11237876; Product type pe : putative enzyme; hypothetical protein 4156712 yiaC 7141504 yiaC Escherichia coli ED1a hypothetical protein YP_002400053.1 4156272 D 585397 CDS YP_002400054.1 218691842 7139693 complement(4156681..4158960) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82119950, 90202748, 2180922, 374979; Product type e : enzyme; biotin sulfoxide reductase 4158960 bisC 7139693 bisC Escherichia coli ED1a biotin sulfoxide reductase YP_002400054.1 4156681 R 585397 CDS YP_002400055.1 218691843 7140458 4159167..4159826 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative outer membrane lipoprotein 4159826 yiaD 7140458 yiaD Escherichia coli ED1a putative outer membrane lipoprotein YP_002400055.1 4159167 D 585397 CDS YP_002400056.1 218691844 7139694 4159930..4160904 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15801772, 11237876, 99030322, 99357626, 9298646, 9811658; Product type e : enzyme; 2-oxo-carboxylic acid reductase 4160904 tiaE 7139694 tiaE Escherichia coli ED1a 2-oxo-carboxylic acid reductase YP_002400056.1 4159930 D 585397 CDS YP_002400057.1 218691845 7141556 complement(4160954..4161664) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4161664 yiaF 7141556 yiaF Escherichia coli ED1a hypothetical protein YP_002400057.1 4160954 R 585397 CDS YP_002400058.1 218691846 7139695 4162098..4162388 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 4162388 yiaG 7139695 yiaG Escherichia coli ED1a putative transcriptional regulator YP_002400058.1 4162098 D 585397 CDS YP_002400059.1 218691847 7139696 4162669..4162881 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20345064, 90115858, 94293754, 94293756, 99177178, 10696873, 1597410, 1961761, 2404279, 7515185, 8197194, 9405743, 9439003, 9692981; Product type f : factor; major cold shock protein 4162881 cspA 7139696 cspA Escherichia coli ED1a major cold shock protein YP_002400059.1 4162669 D 585397 CDS YP_002400060.1 218691848 7142069 complement(4163544..4165613) 1 NC_011745.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta 4165613 glyS 7142069 glyS Escherichia coli ED1a glycyl-tRNA synthetase subunit beta YP_002400060.1 4163544 R 585397 CDS YP_002400061.1 218691849 7142992 complement(4165623..4166534) 1 NC_011745.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 4166534 glyQ 7142992 glyQ Escherichia coli ED1a glycyl-tRNA synthetase subunit alpha YP_002400061.1 4165623 R 585397 CDS YP_002400062.1 218691850 7142991 complement(4166629..4166937) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4166937 ysaB 7142991 ysaB Escherichia coli ED1a hypothetical protein YP_002400062.1 4166629 R 585397 CDS YP_002400063.1 218691851 7143253 4167112..4168107 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4168107 yiaH 7143253 yiaH Escherichia coli ED1a hypothetical protein YP_002400063.1 4167112 D 585397 CDS YP_002400064.1 218691852 7139691 complement(4168630..4168971) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6320721; Product type pm : putative membrane component; hypothetical protein 4168971 yiaB 7139691 yiaB Escherichia coli ED1a hypothetical protein YP_002400064.1 4168630 R 585397 CDS YP_002400065.1 218691853 7139692 complement(4169140..4170594) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6330500, 92366447, 95050816, 6320721; Product type e : enzyme; xylulokinase 4170594 xylB 7139692 xylB Escherichia coli ED1a xylulokinase YP_002400065.1 4169140 R 585397 CDS YP_002400066.1 218691854 7139213 complement(4170666..4171988) 1 NC_011745.1 catalyzes the interconversion of D-xylose to D-xylulose; xylose isomerase 4171988 xylA 7139213 xylA Escherichia coli ED1a xylose isomerase YP_002400066.1 4170666 R 585397 CDS YP_002400067.1 218691855 7139212 4172354..4173346 1 NC_011745.1 periplasmic substrate-binding component of the ATP-dependent xylose transport system; high affinity; D-xylose transporter subunit XylF 4173346 xylF 7139212 xylF Escherichia coli ED1a D-xylose transporter subunit XylF YP_002400067.1 4172354 D 585397 CDS YP_002400068.1 218691856 7139217 4174943..4176124 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94316500; Product type t : transporter; D-xylose ABC transporter membrane protein 4176124 xylH 7139217 xylH Escherichia coli ED1a D-xylose ABC transporter membrane protein YP_002400068.1 4174943 D 585397 CDS YP_002400069.1 218691857 7139218 4176036..4176212 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 4176212 7139218 ECED1_4255 Escherichia coli ED1a hypothetical protein YP_002400069.1 4176036 D 585397 CDS YP_002400070.1 218691858 7142318 4176202..4177380 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6330500, 94316500; Product type r : regulator; DNA-binding transcriptional activator, xylose-binding 4177380 xylR 7142318 xylR Escherichia coli ED1a DNA-binding transcriptional activator, xylose-binding YP_002400070.1 4176202 D 585397 CDS YP_002400071.1 218691859 7139219 complement(4177488..4178312) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1544897; hypothetical protein 4178312 bax 7139219 bax Escherichia coli ED1a hypothetical protein YP_002400071.1 4177488 R 585397 CDS YP_002400072.1 218691860 7140432 4178632..4180662 1 NC_011745.1 periplasmic enzyme that degrades maltodextrins that enter via the outer membrane porin LamB; hydrolyzes alpha-(1,4) glycosidic linkages; contains internal disulfide bonds; periplasmic alpha-amylase 4180662 malS 7140432 malS Escherichia coli ED1a periplasmic alpha-amylase YP_002400072.1 4178632 D 585397 CDS YP_002400073.1 218691861 7142202 4180840..4182093 1 NC_011745.1 transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis; valine--pyruvate transaminase 4182093 avtA 7142202 avtA Escherichia coli ED1a valine--pyruvate transaminase YP_002400073.1 4180840 D 585397 CDS YP_002400074.1 218691862 7140424 complement(4182245..4182718) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative hydrogenase, 4Fe-4S ferredoxin-type component 4182718 yiaI 7140424 yiaI Escherichia coli ED1a putative hydrogenase, 4Fe-4S ferredoxin-type component YP_002400074.1 4182245 R 585397 CDS YP_002400075.1 218691863 7139698 complement(4182820..4183668) 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 20372646, 9826648; Product type r : regulator; DNA-binding transcriptional repressor 4183668 yiaJ 7139698 yiaJ Escherichia coli ED1a DNA-binding transcriptional repressor YP_002400075.1 4182820 R 585397 CDS YP_002400076.1 218691864 7139699 4183869..4184867 1 NC_011745.1 NAD(P)H-dependent; catalyzes the reduction of 2,3-diketo-L-gulonate to 3-keto-L-gulonate; 2,3-diketo-L-gulonate reductase 4184867 yiaK 7139699 yiaK Escherichia coli ED1a 2,3-diketo-L-gulonate reductase YP_002400076.1 4183869 D 585397 CDS YP_002400077.1 218691865 7139700 4184879..4185343 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 21617392; hypothetical protein 4185343 yiaL 7139700 yiaL Escherichia coli ED1a hypothetical protein YP_002400077.1 4184879 D 585397 CDS YP_002400078.1 218691866 7139701 4185366..4186286 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4186286 7139701 ECED1_4265 Escherichia coli ED1a hypothetical protein YP_002400078.1 4185366 D 585397 CDS YP_002400079.1 218691867 7142319 4186400..4186867 1 NC_011745.1 membrane-spanning protein involved in uptake of 2,3-diketo-L-gulonate; part of the tri-partite ATP-independent periplasmic transport system (TRAP) YiaMNO; 2,3-diketo-L-gulonate TRAP transporter small permease YiaM 4186867 yiaM 7142319 yiaM Escherichia coli ED1a 2,3-diketo-L-gulonate TRAP transporter small permease YiaM YP_002400079.1 4186400 D 585397 CDS YP_002400080.1 218691868 7139702 4186672..4188147 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14668138, 21617392; Product type t : transporter; transporter 4188147 yiaN 7139702 yiaN Escherichia coli ED1a transporter YP_002400080.1 4186672 D 585397 CDS YP_002400081.1 218691869 7139703 4188160..4189146 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14668138, 21617392; Product type t : transporter; transporter 4189146 yiaO 7139703 yiaO Escherichia coli ED1a transporter YP_002400081.1 4188160 D 585397 CDS YP_002400082.1 218691870 7139704 4189150..4190646 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21617392, 95050816, 7961955; Product type e : enzyme; L-xylulose kinase 4190646 lyxK 7139704 lyxK Escherichia coli ED1a L-xylulose kinase YP_002400082.1 4189150 D 585397 CDS YP_002400083.1 218691871 7141937 4190643..4191305 1 NC_011745.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate; 3-keto-L-gulonate-6-phosphate decarboxylase 4191305 sgbH 7141937 sgbH Escherichia coli ED1a 3-keto-L-gulonate-6-phosphate decarboxylase YP_002400083.1 4190643 D 585397 CDS YP_002400084.1 218691872 7140323 4191298..4192158 1 NC_011745.1 L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate; putative L-xylulose 5-phosphate 3-epimerase 4192158 sgbU 7140323 sgbU Escherichia coli ED1a putative L-xylulose 5-phosphate 3-epimerase YP_002400084.1 4191298 D 585397 CDS YP_002400085.1 218691873 7141704 4192152..4192847 1 NC_011745.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 4192847 sgbE 7141704 sgbE Escherichia coli ED1a L-ribulose-5-phosphate 4-epimerase YP_002400085.1 4192152 D 585397 CDS YP_002400086.1 218691874 7141406 complement(4192894..4194432) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95286498, 7768815; Product type e : enzyme; aldehyde dehydrogenase B 4194432 aldB 7141406 aldB Escherichia coli ED1a aldehyde dehydrogenase B YP_002400086.1 4192894 R 585397 CDS YP_002400087.1 218691875 7143687 complement(4194540..4195835) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4195835 7143687 ECED1_4274 Escherichia coli ED1a hypothetical protein YP_002400087.1 4194540 R 585397 CDS YP_002400088.1 218691876 7142320 complement(4195965..4197116) 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2935393; Product type e : enzyme; putative alcohol dehydrogenase 4197116 yiaY 7142320 yiaY Escherichia coli ED1a putative alcohol dehydrogenase YP_002400088.1 4195965 R 585397 CDS YP_002400089.1 218691877 7139705 complement(4197307..4199151) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90264431, 91317715, 9315303, 94148228, 2140572, 2531290; Product type f : factor; selenocysteinyl-tRNA-specific translation factor 4199151 selB 7139705 selB Escherichia coli ED1a selenocysteinyl-tRNA-specific translation factor YP_002400089.1 4197307 R 585397 CDS YP_002400090.1 218691878 7141394 complement(4199148..4200539) 1 NC_011745.1 catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis; selenocysteine synthase 4200539 selA 7141394 selA Escherichia coli ED1a selenocysteine synthase YP_002400090.1 4199148 R 585397 CDS YP_002400091.1 218691879 7141393 complement(4200637..4201245) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8387990; Product type pe : putative enzyme; putative glutathione S-transferase 4201245 yibF 7141393 yibF Escherichia coli ED1a putative glutathione S-transferase YP_002400091.1 4200637 R 585397 CDS YP_002400092.1 218691880 7139707 complement(4201316..4202452) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4202452 yibH 7139707 yibH Escherichia coli ED1a hypothetical protein YP_002400092.1 4201316 R 585397 CDS YP_002400093.1 218691881 7139708 complement(4202455..4202817) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4202817 yibI 7139708 yibI Escherichia coli ED1a hypothetical protein YP_002400093.1 4202455 R 585397 CDS YP_002400094.1 218691882 7139709 4203354..4205267 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92052139, 92283796, 94131964, 1946374, 3135464, 3142516, 6309813, 9551558; Product type t : transporter; fused mannitol-specific PTS enzymes: IIA components ; IIB components ; IIC components 4205267 mtlA 7139709 mtlA Escherichia coli ED1a fused mannitol-specific PTS enzymes: IIA components ; IIB components ; IIC components YP_002400094.1 4203354 D 585397 CDS YP_002400095.1 218691883 7139038 4205586..4206734 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90254197, 1964486, 3135464, 6384188, 8300537, 13295236; Product type e : enzyme; mannitol-1-phosphate 5-dehydrogenase 4206734 mtlD 7139038 mtlD Escherichia coli ED1a mannitol-1-phosphate 5-dehydrogenase YP_002400095.1 4205586 D 585397 CDS YP_002400096.1 218691884 7139039 4206734..4207321 1 NC_011745.1 Acts as a repressor of the mtlAD operon; mannitol repressor protein 4207321 mtlR 7139039 mtlR Escherichia coli ED1a mannitol repressor protein YP_002400096.1 4206734 D 585397 CDS YP_002400097.1 218691885 7139040 complement(4207332..4207541) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4207541 yibT 7139040 yibT Escherichia coli ED1a hypothetical protein YP_002400097.1 4207332 R 585397 CDS YP_002400098.1 218691886 7139714 4207825..4208187 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4208187 yibL 7139714 yibL Escherichia coli ED1a hypothetical protein YP_002400098.1 4207825 D 585397 CDS YP_002400099.1 218691887 7139711 complement(4208443..4208679) 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 4208679 7139711 ECED1_4286 Escherichia coli ED1a hypothetical protein YP_002400099.1 4208443 R 585397 CDS YP_002400100.1 218691888 7142321 4208745..4209428 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4209428 7142321 ECED1_4287 Escherichia coli ED1a hypothetical protein YP_002400100.1 4208745 D 585397 CDS YP_002400101.1 218691889 7142322 4209472..4214274 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative hemagglutinin adhesin 4214274 7142322 ECED1_4288 Escherichia coli ED1a putative hemagglutinin adhesin YP_002400101.1 4209472 D 585397 CDS YP_002400102.1 218691890 7142323 4214686..4216341 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94012541, 11283302, 11785976, 8407843; Product type t : transporter; L-lactate permease 4216341 lldP 7142323 lldP Escherichia coli ED1a L-lactate permease YP_002400102.1 4214686 D 585397 CDS YP_002400103.1 218691891 7141897 4216341..4217117 1 NC_011745.1 represses the lctPRD operon; DNA-binding transcriptional repressor LldR 4217117 lldR 7141897 lldR Escherichia coli ED1a DNA-binding transcriptional repressor LldR YP_002400103.1 4216341 D 585397 CDS YP_002400104.1 218691892 7141898 4217114..4218304 1 NC_011745.1 flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration; L-lactate dehydrogenase 4218304 lldD 7141898 lldD Escherichia coli ED1a L-lactate dehydrogenase YP_002400104.1 4217114 D 585397 CDS YP_002400105.1 218691893 7141896 4218352..4218825 1 NC_011745.1 member of the SPOUT superfamily of RNA methyltransferases; no methyltransferase activity observed with certain tRNA substrates; putative tRNA/rRNA methyltransferase YibK 4218825 yibK 7141896 yibK Escherichia coli ED1a putative tRNA/rRNA methyltransferase YibK YP_002400105.1 4218352 D 585397 CDS YP_002400106.1 218691894 7139710 complement(4218880..4219701) 1 NC_011745.1 catalyzes the O-acetylation of serine; serine acetyltransferase 4219701 cysE 7139710 cysE Escherichia coli ED1a serine acetyltransferase YP_002400106.1 4218880 R 585397 CDS YP_002400107.1 218691895 7142111 complement(4219781..4220800) 1 NC_011745.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 4220800 gpsA 7142111 gpsA Escherichia coli ED1a NAD(P)H-dependent glycerol-3-phosphate dehydrogenase YP_002400107.1 4219781 R 585397 CDS YP_002400108.1 218691896 7143015 complement(4220800..4221267) 1 NC_011745.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB 4221267 secB 7143015 secB Escherichia coli ED1a preprotein translocase subunit SecB YP_002400108.1 4220800 R 585397 CDS YP_002400109.1 218691897 7141386 complement(4221331..4221582) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94316500, 95024051, 99175138, 11031118, 7937896, 8636094, 9973569; Product type c : carrier; glutaredoxin 3 4221582 grxC 7141386 grxC Escherichia coli ED1a glutaredoxin 3 YP_002400109.1 4221331 R 585397 CDS YP_002400110.1 218691898 7143026 complement(4221723..4222154) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative rhodanese-related sulfurtransferase 4222154 yibN 7143026 yibN Escherichia coli ED1a putative rhodanese-related sulfurtransferase YP_002400110.1 4221723 R 585397 CDS YP_002400111.1 218691899 7139712 4222399..4223943 1 NC_011745.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate; phosphoglyceromutase 4223943 gpmI 7139712 gpmI Escherichia coli ED1a phosphoglyceromutase YP_002400111.1 4222399 D 585397 CDS YP_002400112.1 218691900 7143013 4223977..4225236 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12113939, 21972773; Product type cp : cell process; hypothetical protein 4225236 envC 7143013 envC Escherichia coli ED1a hypothetical protein YP_002400112.1 4223977 D 585397 CDS YP_002400113.1 218691901 7139800 4225240..4226199 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative polysaccharide deacetylase 4226199 yibQ 7139800 yibQ Escherichia coli ED1a putative polysaccharide deacetylase YP_002400113.1 4225240 D 585397 CDS YP_002400114.1 218691902 7139713 complement(4226186..4227220) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15659689, 2647748; Product type pe : putative enzyme; putative glycosyl transferase 4227220 yibD 7139713 yibD Escherichia coli ED1a putative glycosyl transferase YP_002400114.1 4226186 R 585397 CDS YP_002400115.1 218691903 7139706 complement(4227459..4228484) 1 NC_011745.1 converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism; L-threonine 3-dehydrogenase 4228484 tdh 7139706 tdh Escherichia coli ED1a L-threonine 3-dehydrogenase YP_002400115.1 4227459 R 585397 CDS YP_002400116.1 218691904 7141530 complement(4228494..4229690) 1 NC_011745.1 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine; 2-amino-3-ketobutyrate coenzyme A ligase 4229690 kbl 7141530 kbl Escherichia coli ED1a 2-amino-3-ketobutyrate coenzyme A ligase YP_002400116.1 4228494 R 585397 CDS YP_002400117.1 218691905 7142488 complement(4229965..4230822) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4230822 htrL 7142488 htrL Escherichia coli ED1a hypothetical protein YP_002400117.1 4229965 R 585397 CDS YP_002400118.1 218691906 7140177 4231126..4232058 1 NC_011745.1 catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose; ADP-L-glycero-D-mannoheptose-6-epimerase 4232058 rfaD 7140177 rfaD Escherichia coli ED1a ADP-L-glycero-D-mannoheptose-6-epimerase YP_002400118.1 4231126 D 585397 CDS YP_002400119.1 218691907 7139172 4232068..4233114 1 NC_011745.1 catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core; ADP-heptose:LPS heptosyltransferase II 4233114 waaF 7139172 waaF Escherichia coli ED1a ADP-heptose:LPS heptosyltransferase II YP_002400119.1 4232068 D 585397 CDS YP_002400120.1 218691908 7139173 4233118..4234110 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20507564, 92250420, 93239678, 9446588, 1624462, 8478319; Product type e : enzyme; ADP-heptose:LPS heptosyl transferase I 4234110 waaC 7139173 waaC Escherichia coli ED1a ADP-heptose:LPS heptosyl transferase I YP_002400120.1 4233118 D 585397 CDS YP_002400121.1 218691909 7139171 4234107..4235315 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1657881; Product type e : enzyme; O-antigen ligase 4235315 rfaL 7139171 rfaL Escherichia coli ED1a O-antigen ligase YP_002400121.1 4234107 D 585397 CDS YP_002400122.1 218691910 7141596 complement(4235350..4236492) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; lipopolysaccharide 1, 2-N-acetylglucosaminetransferase 4236492 rfaK 7141596 rfaK Escherichia coli ED1a lipopolysaccharide 1, 2-N-acetylglucosaminetransferase YP_002400122.1 4235350 R 585397 CDS YP_002400123.1 218691911 7141595 complement(4236501..4237514) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92210496, 92250420, 92325066, 99251135, 1624461; Product type e : enzyme; lipopolysaccharide 1,2-glucosyltransferase 4237514 rfaJ 7141595 rfaJ Escherichia coli ED1a lipopolysaccharide 1,2-glucosyltransferase YP_002400123.1 4236501 R 585397 CDS YP_002400124.1 218691912 7141594 complement(4237539..4238246) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1624462, 8041620, 9278503, 92250420, 92325067, 9756860; Product type e : enzyme; lipopolysaccharide core biosynthesis protein 4238246 rfaY 7141594 rfaY Escherichia coli ED1a lipopolysaccharide core biosynthesis protein YP_002400124.1 4237539 R 585397 CDS YP_002400125.1 218691913 7141597 complement(4238272..4239279) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92210496, 92250420, 92325066, 9765561, 1624461; Product type e : enzyme; lipopolysaccharide 1,3-galactosyltransferase 4239279 rfaI 7141597 rfaI Escherichia coli ED1a lipopolysaccharide 1,3-galactosyltransferase YP_002400125.1 4238272 R 585397 CDS YP_002400126.1 218691914 7141593 complement(4239322..4240128) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21101922, 92121133, 92210496, 9756860, 1732225; Product type e : enzyme; kinase that phosphorylates core heptose of lipopolysaccharide 4240128 waaP 7141593 waaP Escherichia coli ED1a kinase that phosphorylates core heptose of lipopolysaccharide YP_002400126.1 4239322 R 585397 CDS YP_002400127.1 218691915 7139175 complement(4240112..4241236) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92121133, 92210496, 92250420, 1447141, 1732225, 7988890; Product type e : enzyme; glucosyltransferase I 4241236 waaG 7139175 waaG Escherichia coli ED1a glucosyltransferase I YP_002400127.1 4240112 R 585397 CDS YP_002400128.1 218691916 7139174 complement(4241233..4242291) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9756860, 1447141, 1732225; Product type e : enzyme; lipopolysaccharide core biosynthesis protein 4242291 waaQ 7139174 waaQ Escherichia coli ED1a lipopolysaccharide core biosynthesis protein YP_002400128.1 4241233 R 585397 CDS YP_002400129.1 218691917 7139176 4242704..4243981 1 NC_011745.1 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A; 3-deoxy-D-manno-octulosonic-acid transferase 4243981 kdtA 7139176 kdtA Escherichia coli ED1a 3-deoxy-D-manno-octulosonic-acid transferase YP_002400129.1 4242704 D 585397 CDS YP_002400130.1 218691918 7142502 4243989..4244468 1 NC_011745.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 4244468 coaD 7142502 coaD Escherichia coli ED1a phosphopantetheine adenylyltransferase YP_002400130.1 4243989 D 585397 CDS YP_002400131.1 218691919 7142029 complement(4244507..4245316) 1 NC_011745.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 4245316 mutM 7142029 mutM Escherichia coli ED1a formamidopyrimidine-DNA glycosylase YP_002400131.1 4244507 R 585397 CDS YP_002400132.1 218691920 7139056 complement(4245414..4245581) 1 NC_011745.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 4245581 rpmG 7139056 rpmG Escherichia coli ED1a 50S ribosomal protein L33 YP_002400132.1 4245414 R 585397 CDS YP_002400133.1 218691921 7141481 complement(4245602..4245838) 1 NC_011745.1 required for 70S ribosome assembly; 50S ribosomal protein L28 4245838 rpmB 7141481 rpmB Escherichia coli ED1a 50S ribosomal protein L28 YP_002400133.1 4245602 R 585397 CDS YP_002400134.1 218691922 7141476 complement(4246055..4246723) 1 NC_011745.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC 4246723 radC 7141476 radC Escherichia coli ED1a DNA repair protein RadC YP_002400134.1 4246055 R 585397 CDS YP_002400135.1 218691923 7139725 4246895..4248115 1 NC_011745.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 4248115 dfp 7139725 dfp Escherichia coli ED1a bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase YP_002400135.1 4246895 D 585397 CDS YP_002400136.1 218691924 7143100 4248096..4248551 1 NC_011745.1 catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 4248551 dut 7143100 dut Escherichia coli ED1a deoxyuridine 5'-triphosphate nucleotidohydrolase YP_002400136.1 4248096 D 585397 CDS YP_002400137.1 218691925 7142742 4248658..4249254 1 NC_011745.1 FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly; nucleoid occlusion protein 4249254 slmA 7142742 slmA Escherichia coli ED1a nucleoid occlusion protein YP_002400137.1 4248658 D 585397 CDS YP_002400138.1 218691926 7140841 complement(4249291..4249932) 1 NC_011745.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 4249932 pyrE 7140841 pyrE Escherichia coli ED1a orotate phosphoribosyltransferase YP_002400138.1 4249291 R 585397 CDS YP_002400139.1 218691927 7141234 complement(4249998..4250738) 1 NC_011745.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 4250738 rph 7141234 rph Escherichia coli ED1a ribonuclease PH YP_002400139.1 4249998 R 585397 CDS YP_002400140.1 218691928 7141448 4250841..4251704 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4251704 yicC 7141448 yicC Escherichia coli ED1a hypothetical protein YP_002400140.1 4250841 D 585397 CDS YP_002400141.1 218691929 7139715 4251956..4252573 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4252573 yicG 7139715 yicG Escherichia coli ED1a hypothetical protein YP_002400141.1 4251956 D 585397 CDS YP_002400142.1 218691930 7139717 complement(4252570..4254252) 1 NC_011745.1 this ligase is similar to LigA but it lacks the C-terminal BRCT domain; catalyzes strand joining of nicked DNA in the presence of a divalent cation and NAD+; NAD-dependent DNA ligase LigB 4254252 ligB 7139717 ligB Escherichia coli ED1a NAD-dependent DNA ligase LigB YP_002400142.1 4252570 R 585397 CDS YP_002400143.1 218691931 7141886 4254510..4255133 1 NC_011745.1 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 4255133 gmk 7141886 gmk Escherichia coli ED1a guanylate kinase YP_002400143.1 4254510 D 585397 CDS YP_002400144.1 218691932 7142995 4255188..4255463 1 NC_011745.1 promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 4255463 rpoZ 7142995 rpoZ Escherichia coli ED1a DNA-directed RNA polymerase subunit omega YP_002400144.1 4255188 D 585397 CDS YP_002400145.1 218691933 7140082 4255482..4257590 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12224635, 89255395, 93266525, 94068533, 2005134, 2549050; Product type e : enzyme; bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 4257590 spoT 7140082 spoT Escherichia coli ED1a bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase YP_002400145.1 4255482 D 585397 CDS YP_002400146.1 218691934 7143831 4257597..4258286 1 NC_011745.1 specifically modifies tRNA at position G18; tRNA guanosine-2'-O-methyltransferase 4258286 trmH 7143831 trmH Escherichia coli ED1a tRNA guanosine-2'-O-methyltransferase YP_002400146.1 4257597 D 585397 CDS YP_002400147.1 218691935 7140817 4258292..4260373 1 NC_011745.1 catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 4260373 recG 7140817 recG Escherichia coli ED1a ATP-dependent DNA helicase RecG YP_002400147.1 4258292 D 585397 CDS YP_002400148.1 218691936 7141579 complement(4260407..4261612) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91203811, 93106943, 1544582, 2017136, 2254324; Product type t : transporter; glutamate transporter 4261612 gltS 7141579 gltS Escherichia coli ED1a glutamate transporter YP_002400148.1 4260407 R 585397 CDS YP_002400149.1 218691937 7142986 4261892..4263283 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 4263283 yicE 7142986 yicE Escherichia coli ED1a putative transporter YP_002400149.1 4261892 D 585397 CDS YP_002400150.1 218691938 7139716 4263404..4265113 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4265113 yicH 7139716 yicH Escherichia coli ED1a hypothetical protein YP_002400150.1 4263404 D 585397 CDS YP_002400151.1 218691939 7139718 complement(4265157..4265876) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative sugar related regulatory protein 4265876 7139718 ECED1_4341 Escherichia coli ED1a putative sugar related regulatory protein YP_002400151.1 4265157 R 585397 CDS YP_002400152.1 218691940 7142324 complement(4265818..4266783) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sugar kinase/transcriptional regulator. ATPase domain 4266783 7142324 ECED1_4342 Escherichia coli ED1a putative sugar kinase/transcriptional regulator. ATPase domain YP_002400152.1 4265818 R 585397 CDS YP_002400153.1 218691941 7142325 complement(4266798..4267658) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 4267658 7142325 ECED1_4343 Escherichia coli ED1a hypothetical protein YP_002400153.1 4266798 R 585397 CDS YP_002400154.1 218691942 7142326 complement(4267739..4268590) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sugar aldolase 4268590 7142326 ECED1_4344 Escherichia coli ED1a putative sugar aldolase YP_002400154.1 4267739 R 585397 CDS YP_002400155.1 218691943 7142327 complement(4268602..4269693) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative phosphotransferase system, fructose-specific IIC component 4269693 7142327 ECED1_4345 Escherichia coli ED1a putative phosphotransferase system, fructose-specific IIC component YP_002400155.1 4268602 R 585397 CDS YP_002400156.1 218691944 7142328 complement(4269718..4270032) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative phosphotransferase system, fructose-specific IIB subunit 4270032 7142328 ECED1_4346 Escherichia coli ED1a putative phosphotransferase system, fructose-specific IIB subunit YP_002400156.1 4269718 R 585397 CDS YP_002400157.1 218691945 7142329 complement(4270050..4270520) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative phosphotransferase system (PTS), fructose-specific IIA component 4270520 7142329 ECED1_4347 Escherichia coli ED1a putative phosphotransferase system (PTS), fructose-specific IIA component YP_002400157.1 4270050 R 585397 CDS YP_002400158.1 218691946 7142330 complement(4270547..4272100) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative PTS system transcriptional antiterminator 4272100 7142330 ECED1_4348 Escherichia coli ED1a putative PTS system transcriptional antiterminator YP_002400158.1 4270547 R 585397 CDS YP_002400159.1 218691947 7142331 complement(4272395..4274713) 1 NC_011745.1 catalyzes the transfer of alpha-xylosyl residue from alpha-xyloside to xylose, glucose, mannose, fructose, maltose, isomaltose, nigerose, kojibiose, sucrose, and trehalose; shows higher activity against alpha-xylosyl fluoride, isoprimeverose (6-O-alpha-xylopyranosyl-glucopyranose), and alpha-xyloside in xyloglucan oligosaccharides; alpha-xylosidase YicI 4274713 yicI 7142331 yicI Escherichia coli ED1a alpha-xylosidase YicI YP_002400159.1 4272395 R 585397 CDS YP_002400160.1 218691948 7139719 complement(4274723..4276105) 1 NC_011745.1 may be involved in the transport of galactosides-pentoses-hexuronides; putative transporter 4276105 yicJ 7139719 yicJ Escherichia coli ED1a putative transporter YP_002400160.1 4274723 R 585397 CDS YP_002400161.1 218691949 7140579 4276416..4277582 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative RhuM-like cytoplasmic protein 4277582 7140579 ECED1_4351 Escherichia coli ED1a putative RhuM-like cytoplasmic protein YP_002400161.1 4276416 D 585397 CDS YP_002400162.1 218691950 7142332 4278152..4278649 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4278649 7142332 ECED1_4352 Escherichia coli ED1a hypothetical protein YP_002400162.1 4278152 D 585397 CDS YP_002400163.1 218691951 7142333 4278816..4279739 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4279739 yicL 7142333 yicL Escherichia coli ED1a hypothetical protein YP_002400163.1 4278816 D 585397 CDS YP_002400164.1 218691952 7139721 complement(4279743..4280561) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88298691, 89359178, 9914480, 3003106; Product type lp : lipoprotein; cytoplasmic membrane lipoprotein-28 4280561 nlpA 7139721 nlpA Escherichia coli ED1a cytoplasmic membrane lipoprotein-28 YP_002400164.1 4279743 R 585397 CDS YP_002400165.1 218691953 7140397 4280714..4281076 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4281076 yicS 7140397 yicS Escherichia coli ED1a hypothetical protein YP_002400165.1 4280714 D 585397 CDS YP_002400166.1 218691954 7139726 complement(4281117..4282472) 1 NC_011745.1 experimental results in Escherichia coli suggest that this gene encodes an inosine export protein; member of major facilitator superfamily; MFS; ribonucleoside transporter 4282472 nepI 7139726 nepI Escherichia coli ED1a ribonucleoside transporter YP_002400166.1 4281117 R 585397 CDS YP_002400167.1 218691955 7139722 complement(4282518..4282970) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4282970 yicN 7139722 yicN Escherichia coli ED1a hypothetical protein YP_002400167.1 4282518 R 585397 CDS YP_002400168.1 218691956 7139723 complement(4283023..4284357) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative xanthine/uracil permease 4284357 yicO 7139723 yicO Escherichia coli ED1a putative xanthine/uracil permease YP_002400168.1 4283023 R 585397 CDS YP_002400169.1 218691957 7139724 4284532..4286298 1 NC_011745.1 catalyzes the formation of hypoxanthine from adenine; in E. coli this activity has been detected in mutant strains but not in wild type; cryptic adenine deaminase 4286298 ade 7139724 ade Escherichia coli ED1a cryptic adenine deaminase YP_002400169.1 4284532 D 585397 CDS YP_002400170.1 218691958 7143659 complement(4286344..4287735) 1 NC_011745.1 cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate; sugar phosphate antiporter 4287735 uhpT 7143659 uhpT Escherichia coli ED1a sugar phosphate antiporter YP_002400170.1 4286344 R 585397 CDS YP_002400171.1 218691959 7138881 complement(4287873..4289192) 1 NC_011745.1 membrane protein regulates uhpT expression; regulatory protein UhpC 4289192 uhpC 7138881 uhpC Escherichia coli ED1a regulatory protein UhpC YP_002400171.1 4287873 R 585397 CDS YP_002400172.1 218691960 7138880 complement(4289202..4290704) 1 NC_011745.1 Member of the two-component regulatory system UhpB/UhpA involved in the regulation of the uptake of hexose ph; sensory histidine kinase UhpB 4290704 uhpB 7138880 uhpB Escherichia coli ED1a sensory histidine kinase UhpB YP_002400172.1 4289202 R 585397 CDS YP_002400173.1 218691961 7138879 complement(4290704..4291294) 1 NC_011745.1 response regulator in two-component regulatory system wtih UhpB; phosphorylated UhpA is a positive activator uhpT, a hexose phosphates transporter; DNA-binding transcriptional activator UhpA 4291294 uhpA 7138879 uhpA Escherichia coli ED1a DNA-binding transcriptional activator UhpA YP_002400173.1 4290704 R 585397 CDS YP_002400174.1 218691962 7138878 4291709..4292569 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4292569 7138878 ECED1_4365 Escherichia coli ED1a hypothetical protein YP_002400174.1 4291709 D 585397 CDS YP_002400175.1 218691963 7142334 complement(4292760..4293050) 1 NC_011745.1 with IlvB catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase small subunit; acetolactate synthase 1 regulatory subunit 4293050 ilvN 7142334 ilvN Escherichia coli ED1a acetolactate synthase 1 regulatory subunit YP_002400175.1 4292760 R 585397 CDS YP_002400176.1 218691964 7141105 complement(4293054..4294742) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 2989782, 85242083, 92380929, 2989781; Product type e : enzyme; acetolactate synthase catalytic subunit 4294742 ilvB 7141105 ilvB Escherichia coli ED1a acetolactate synthase catalytic subunit YP_002400176.1 4293054 R 585397 CDS YP_002400177.1 218691965 7140236 complement(4294848..4294946) 1 NC_011745.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide; ilvB operon leader peptide 4294946 ivbL 7140236 ivbL Escherichia coli ED1a ilvB operon leader peptide YP_002400177.1 4294848 R 585397 CDS YP_002400178.1 218691966 7142476 4295347..4296531 1 NC_011745.1 multidrug efflux protein involved in adaptation to low energy shock; multidrug resistance protein D 4296531 emrD 7142476 emrD Escherichia coli ED1a multidrug resistance protein D YP_002400178.1 4295347 D 585397 CDS YP_002400179.1 218691967 7139787 complement(4296539..4297036) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 4297036 yidF 7139787 yidF Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002400179.1 4296539 R 585397 CDS YP_002400180.1 218691968 7139732 complement(4297033..4297395) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4297395 yidG 7139732 yidG Escherichia coli ED1a hypothetical protein YP_002400180.1 4297033 R 585397 CDS YP_002400181.1 218691969 7139733 complement(4297385..4297732) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4297732 yidH 7139733 yidH Escherichia coli ED1a hypothetical protein YP_002400181.1 4297385 R 585397 CDS YP_002400182.1 218691970 7139734 complement(4297792..4299285) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sulfatase/phosphatase 4299285 yidJ 7139734 yidJ Escherichia coli ED1a putative sulfatase/phosphatase YP_002400182.1 4297792 R 585397 CDS YP_002400183.1 218691971 7139735 complement(4299282..4300997) 1 NC_011745.1 uncharacterized member of the SSS superfamily of sodium-dependent solute transporters; unknown function; putative symporter YidK 4300997 yidK 7139735 yidK Escherichia coli ED1a putative symporter YidK YP_002400183.1 4299282 R 585397 CDS YP_002400184.1 218691972 7139736 4301134..4302030 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 4302030 yidL 7139736 yidL Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002400184.1 4301134 D 585397 CDS YP_002400185.1 218691973 7139737 complement(4302120..4303781) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1356969; Product type pt : putative transporter; hypothetical protein 4303781 yidE 7139737 yidE Escherichia coli ED1a hypothetical protein YP_002400185.1 4302120 R 585397 CDS YP_002400186.1 218691974 7139731 complement(4303978..4304406) 1 NC_011745.1 16 kDa heat shock protein B; associates with aggregated proteins, together with ibpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; ATP-independent; heat shock chaperone IbpB 4304406 ibpB 7139731 ibpB Escherichia coli ED1a heat shock chaperone IbpB YP_002400186.1 4303978 R 585397 CDS YP_002400187.1 218691975 7140216 complement(4304518..4304931) 1 NC_011745.1 with IbpB associates with aggregated proteins to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; heat shock protein IbpA 4304931 ibpA 7140216 ibpA Escherichia coli ED1a heat shock protein IbpA YP_002400187.1 4304518 R 585397 CDS YP_002400188.1 218691976 7140215 4305237..4305569 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4305569 yidQ 7140215 yidQ Escherichia coli ED1a hypothetical protein YP_002400188.1 4305237 D 585397 CDS YP_002400189.1 218691977 7139738 complement(4305573..4306787) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4306787 yidR 7139738 yidR Escherichia coli ED1a hypothetical protein YP_002400189.1 4305573 R 585397 CDS YP_002400190.1 218691978 7139739 4306867..4307988 1 NC_011745.1 FAD/NAD(P)-binding domain; putative oxidoreductase 4307988 cbrA 7139739 cbrA Escherichia coli ED1a putative oxidoreductase YP_002400190.1 4306867 D 585397 CDS YP_002400191.1 218691979 7139311 complement(4307949..4309241) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 79020349; Product type t : transporter; D-galactonate transporter 4309241 dgoT 7139311 dgoT Escherichia coli ED1a D-galactonate transporter YP_002400191.1 4307949 R 585397 CDS YP_002400192.1 218691980 7143107 complement(4309361..4310509) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 79020349; Product type e : enzyme; galactonate dehydratase 4310509 dgoD 7143107 dgoD Escherichia coli ED1a galactonate dehydratase YP_002400192.1 4309361 R 585397 CDS YP_002400193.1 218691981 7143104 complement(4310506..4311123) 1 NC_011745.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-galactonate 6-phosphate; functions in galactonate metabolism; 2-dehydro-3-deoxy-6-phosphogalactonate aldolase 4311123 dgoA 7143104 dgoA Escherichia coli ED1a 2-dehydro-3-deoxy-6-phosphogalactonate aldolase YP_002400193.1 4310506 R 585397 CDS YP_002400194.1 218691982 7143103 complement(4311107..4311985) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 79020349; Product type e : enzyme; 2-oxo-3-deoxygalactonate kinase 4311985 dgoK 7143103 dgoK Escherichia coli ED1a 2-oxo-3-deoxygalactonate kinase YP_002400194.1 4311107 R 585397 CDS YP_002400195.1 218691983 7143105 complement(4311982..4312671) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 79020349; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 4312671 dgoR 7143105 dgoR Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002400195.1 4311982 R 585397 CDS YP_002400196.1 218691984 7143106 4312932..4313606 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein 4313606 yidX 7143106 yidX Escherichia coli ED1a hypothetical protein YP_002400196.1 4312932 D 585397 CDS YP_002400197.1 218691985 7139740 complement(4313650..4314462) 1 NC_011745.1 YidA; catalyzes the dephosphorylation of erythrose 4-phosphate (preferred substrate), mannose 1-phosphate and p-nitrophenyl phosphate; hydrolyzes the alpha-D-glucose-1-phosphate but not the beta form; member of the haloacid dehalogenase-like hydrolases superfamily and Cof family of proteins; sugar phosphatase 4314462 yidA 7139740 yidA Escherichia coli ED1a sugar phosphatase YP_002400197.1 4313650 R 585397 CDS YP_002400198.1 218691986 7139727 complement(4314577..4314975) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4314975 yidB 7139727 yidB Escherichia coli ED1a hypothetical protein YP_002400198.1 4314577 R 585397 CDS YP_002400199.1 218691987 7139728 complement(4315215..4317629) 1 NC_011745.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 4317629 gyrB 7139728 gyrB Escherichia coli ED1a DNA gyrase subunit B YP_002400199.1 4315215 R 585397 CDS YP_002400200.1 218691988 7139853 complement(4317658..4318731) 1 NC_011745.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 4318731 recF 7139853 recF Escherichia coli ED1a recombination protein F YP_002400200.1 4317658 R 585397 CDS YP_002400201.1 218691989 7141578 complement(4318731..4319831) 1 NC_011745.1 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 4319831 dnaN 7141578 dnaN Escherichia coli ED1a DNA polymerase III subunit beta YP_002400201.1 4318731 R 585397 CDS YP_002400202.1 218691990 7140509 complement(4319836..4321239) 1 NC_011745.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 4321239 dnaA 7140509 dnaA Escherichia coli ED1a chromosomal replication initiation protein YP_002400202.1 4319836 R 585397 CDS YP_002400203.1 218691991 7140502 4321846..4321986 1 NC_011745.1 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 4321986 rpmH 7140502 rpmH Escherichia coli ED1a 50S ribosomal protein L34 YP_002400203.1 4321846 D 585397 CDS YP_002400204.1 218691992 7141482 4322003..4322362 1 NC_011745.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 4322362 rnpA 7141482 rnpA Escherichia coli ED1a ribonuclease P YP_002400204.1 4322003 D 585397 CDS YP_002400205.1 218691993 7141440 4322326..4322583 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4322583 yidD 7141440 yidD Escherichia coli ED1a hypothetical protein YP_002400205.1 4322326 D 585397 CDS YP_002400206.1 218691994 7139730 4322586..4324232 1 NC_011745.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; putative inner membrane protein translocase component YidC 4324232 yidC 7139730 yidC Escherichia coli ED1a putative inner membrane protein translocase component YidC YP_002400206.1 4322586 D 585397 CDS YP_002400207.1 218691995 7139729 4324338..4325702 1 NC_011745.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 4325702 trmE 7139729 trmE Escherichia coli ED1a tRNA modification GTPase TrmE YP_002400207.1 4324338 D 585397 CDS YP_002400208.1 218691996 7140816 4325944..4326018 1 NC_011745.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide; tryptophanase leader peptide 4326018 tnaC 7140816 tnaC Escherichia coli ED1a tryptophanase leader peptide YP_002400208.1 4325944 D 585397 CDS YP_002400209.1 218691997 7141565 4326239..4327654 1 NC_011745.1 tryptophan indole-lyase; catalyzes the formation of indole and pyruvate from tryptophan; tryptophanase 4327654 tnaA 7141565 tnaA Escherichia coli ED1a tryptophanase YP_002400209.1 4326239 D 585397 CDS YP_002400210.1 218691998 7141563 4327746..4328993 1 NC_011745.1 tryptophan transporter of low affinity; tryptophan permease TnaB 4328993 tnaB 7141563 tnaB Escherichia coli ED1a tryptophan permease TnaB YP_002400210.1 4327746 D 585397 CDS YP_002400211.1 218691999 7141564 4329125..4330300 1 NC_011745.1 Confers resistance to chloramphenicol; multidrug efflux system protein MdtL 4330300 mdtL 7141564 mdtL Escherichia coli ED1a multidrug efflux system protein MdtL YP_002400211.1 4329125 D 585397 CDS YP_002400212.1 218692000 7142238 4330275..4331234 1 NC_011745.1 Involved in anaerobic NO protection; DNA-binding transcriptional regulator YidZ 4331234 yidZ 7142238 yidZ Escherichia coli ED1a DNA-binding transcriptional regulator YidZ YP_002400212.1 4330275 D 585397 CDS YP_002400213.1 218692001 7139741 4331379..4332140 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphopantetheinyl transferase 4332140 yieE 7139741 yieE Escherichia coli ED1a putative phosphopantetheinyl transferase YP_002400213.1 4331379 D 585397 CDS YP_002400214.1 218692002 7139742 4332162..4332728 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14766567; Product type e : enzyme; chromate reductase, Class I, flavoprotein 4332728 yieF 7139742 yieF Escherichia coli ED1a chromate reductase, Class I, flavoprotein YP_002400214.1 4332162 D 585397 CDS YP_002400215.1 218692003 7139743 complement(4332781..4334118) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4334118 yieG 7139743 yieG Escherichia coli ED1a hypothetical protein YP_002400215.1 4332781 R 585397 CDS YP_002400216.1 218692004 7139744 4334285..4334950 1 NC_011745.1 YieH; catalyzes the dephosphorylation of phosphoenolpyruvate, AMP and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; member of the haloacid dehalogenase-like hydrolases superfamily; 6-phosphogluconate phosphatase 4334950 yieH 7139744 yieH Escherichia coli ED1a 6-phosphogluconate phosphatase YP_002400216.1 4334285 D 585397 CDS YP_002400217.1 218692005 7139745 4335017..4335490 1 NC_011745.1 might be involved in hypersensitivity to nitrofurzone; putative inner membrane protein 4335490 yieI 7139745 yieI Escherichia coli ED1a putative inner membrane protein YP_002400217.1 4335017 D 585397 CDS YP_002400218.1 218692006 7139746 complement(4335572..4336294) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative 6-phosphogluconolactonase 4336294 yieK 7139746 yieK Escherichia coli ED1a putative 6-phosphogluconolactonase YP_002400218.1 4335572 R 585397 CDS YP_002400219.1 218692007 7139747 complement(4336309..4337505) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative xylanase 4337505 yieL 7139747 yieL Escherichia coli ED1a putative xylanase YP_002400219.1 4336309 R 585397 CDS YP_002400220.1 218692008 7139748 complement(4337505..4339121) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10027967; Product type t : transporter; carbohydrate-specific outer membrane porin, cryptic 4339121 bglH 7139748 bglH Escherichia coli ED1a carbohydrate-specific outer membrane porin, cryptic YP_002400220.1 4337505 R 585397 CDS YP_002400221.1 218692009 7140447 complement(4339207..4340601) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87222180, 88297127, 92334140, 3034860, 3309161; Product type e : enzyme; cryptic phospho-beta-glucosidase B 4340601 bglB 7140447 bglB Escherichia coli ED1a cryptic phospho-beta-glucosidase B YP_002400221.1 4339207 R 585397 CDS YP_002400222.1 218692010 7140444 complement(4340620..4342569) 1 NC_011745.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system beta-glucoside-specific transporter subunits IIABC 4342569 bglF 7140444 bglF Escherichia coli ED1a PTS system beta-glucoside-specific transporter subunits IIABC YP_002400222.1 4340620 R 585397 CDS YP_002400223.1 218692011 7140445 complement(4342628..4343464) 1 NC_011745.1 positive regulator of the beta-glucoside operon; transcriptional antiterminator; transcriptional antiterminator BglG 4343464 bglG 7140445 bglG Escherichia coli ED1a transcriptional antiterminator BglG YP_002400223.1 4342628 R 585397 CDS YP_002400224.1 218692012 7140446 complement(4343750..4344475) 1 NC_011745.1 regulates several genes involved in high affinity phosphate uptake; under conditions of high phosphate concentrations downregulates the PHO regulon; transcriptional regulator PhoU 4344475 phoU 7140446 phoU Escherichia coli ED1a transcriptional regulator PhoU YP_002400224.1 4343750 R 585397 CDS YP_002400225.1 218692013 7144109 complement(4344490..4345263) 1 NC_011745.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 4345263 pstB 7144109 pstB Escherichia coli ED1a phosphate transporter ATP-binding protein YP_002400225.1 4344490 R 585397 CDS YP_002400226.1 218692014 7141198 complement(4345354..4346244) 1 NC_011745.1 Part of the ABC transporter complex PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease subunit PtsA 4346244 pstA 7141198 pstA Escherichia coli ED1a phosphate transporter permease subunit PtsA YP_002400226.1 4345354 R 585397 CDS YP_002400227.1 218692015 7141197 complement(4346244..4347203) 1 NC_011745.1 part of the ATP-dependent phosphate uptake system PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease subunit PstC 4347203 pstC 7141197 pstC Escherichia coli ED1a phosphate transporter permease subunit PstC YP_002400227.1 4346244 R 585397 CDS YP_002400228.1 218692016 7141199 complement(4347290..4348330) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90133909, 2215649, 6321434, 6365894, 9228942, 9298646, 9671506; Product type t : transporter; phosphate ABC transporter periplasmic substrate-binding protein PstS 4348330 pstS 7141199 pstS Escherichia coli ED1a phosphate ABC transporter periplasmic substrate-binding protein PstS YP_002400228.1 4347290 R 585397 CDS YP_002400229.1 218692017 7141200 complement(4348644..4350473) 1 NC_011745.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 4350473 glmS 7141200 glmS Escherichia coli ED1a glucosamine--fructose-6-phosphate aminotransferase YP_002400229.1 4348644 R 585397 CDS YP_002400230.1 218692018 7143193 complement(4350634..4352004) 1 NC_011745.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 4352004 glmU 7143193 glmU Escherichia coli ED1a bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase YP_002400230.1 4350634 R 585397 CDS YP_002400231.1 218692019 7143194 complement(4352358..4352777) 1 NC_011745.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon 4352777 atpC 7143194 atpC Escherichia coli ED1a F0F1 ATP synthase subunit epsilon YP_002400231.1 4352358 R 585397 CDS YP_002400232.1 218692020 7140410 complement(4352798..4354180) 1 NC_011745.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta 4354180 atpD 7140410 atpD Escherichia coli ED1a F0F1 ATP synthase subunit beta YP_002400232.1 4352798 R 585397 CDS YP_002400233.1 218692021 7140411 complement(4354207..4355070) 1 NC_011745.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma 4355070 atpG 7140411 atpG Escherichia coli ED1a F0F1 ATP synthase subunit gamma YP_002400233.1 4354207 R 585397 CDS YP_002400234.1 218692022 7140414 complement(4355121..4356662) 1 NC_011745.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha 4356662 atpA 7140414 atpA Escherichia coli ED1a F0F1 ATP synthase subunit alpha YP_002400234.1 4355121 R 585397 CDS YP_002400235.1 218692023 7140408 complement(4356675..4357208) 1 NC_011745.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta 4357208 atpH 7140408 atpH Escherichia coli ED1a F0F1 ATP synthase subunit delta YP_002400235.1 4356675 R 585397 CDS YP_002400236.1 218692024 7140415 complement(4357223..4357693) 1 NC_011745.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B 4357693 atpF 7140415 atpF Escherichia coli ED1a F0F1 ATP synthase subunit B YP_002400236.1 4357223 R 585397 CDS YP_002400237.1 218692025 7140413 complement(4357755..4357994) 1 NC_011745.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C 4357994 atpE 7140413 atpE Escherichia coli ED1a F0F1 ATP synthase subunit C YP_002400237.1 4357755 R 585397 CDS YP_002400238.1 218692026 7140412 complement(4358041..4358856) 1 NC_011745.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A 4358856 atpB 7140412 atpB Escherichia coli ED1a F0F1 ATP synthase subunit A YP_002400238.1 4358041 R 585397 CDS YP_002400239.1 218692027 7140409 complement(4358865..4359245) 1 NC_011745.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation; F0F1 ATP synthase subunit I 4359245 atpI 7140409 atpI Escherichia coli ED1a F0F1 ATP synthase subunit I YP_002400239.1 4358865 R 585397 CDS YP_002400240.1 218692028 7140416 complement(4359862..4360485) 1 NC_011745.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 4360485 gidB 7140416 gidB Escherichia coli ED1a 16S rRNA methyltransferase GidB YP_002400240.1 4359862 R 585397 CDS YP_002400241.1 218692029 7143177 complement(4360549..4362438) 1 NC_011745.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA 4362438 gidA 7143177 gidA Escherichia coli ED1a tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA YP_002400241.1 4360549 R 585397 CDS YP_002400242.1 218692030 7143176 complement(4362817..4363260) 1 NC_011745.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin 4363260 mioC 7143176 mioC Escherichia coli ED1a flavodoxin YP_002400242.1 4362817 R 585397 CDS YP_002400243.1 218692031 7138987 complement(4363350..4363808) 1 NC_011745.1 transcriptional repressor of asnA which codes for aspartate-ammonia ligase; DNA-binding transcriptional regulator AsnC 4363808 asnC 7138987 asnC Escherichia coli ED1a DNA-binding transcriptional regulator AsnC YP_002400243.1 4363350 R 585397 CDS YP_002400244.1 218692032 7142647 4363960..4364952 1 NC_011745.1 catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA 4364952 asnA 7142647 asnA Escherichia coli ED1a asparagine synthetase AsnA YP_002400244.1 4363960 D 585397 CDS YP_002400245.1 218692033 7142645 complement(4364957..4366408) 1 NC_011745.1 contains a von Willibrand factor type A domain; stimulates the ATPase activity of RavA; hypothetical protein 4366408 yieM 7142645 yieM Escherichia coli ED1a hypothetical protein YP_002400245.1 4364957 R 585397 CDS YP_002400246.1 218692034 7139749 complement(4366402..4367898) 1 NC_011745.1 interacts with LdcI, lysine decarboxylase; may be active in late log/ early stationary phase; regulatory ATPase RavA 4367898 ravA 7139749 ravA Escherichia coli ED1a regulatory ATPase RavA YP_002400246.1 4366402 R 585397 CDS YP_002400247.1 218692035 7141252 4368121..4369989 1 NC_011745.1 Responsible for the low-affinity transport of potassium into the cell; involved in potassium ion uptake under hyper-osmotic stress at a low pH; potassium transport protein Kup 4369989 trkD 7141252 trkD Escherichia coli ED1a potassium transport protein Kup YP_002400247.1 4368121 D 585397 CDS YP_002400248.1 218692036 7140811 4370156..4370575 1 NC_011745.1 cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source; D-ribose pyranase 4370575 rbsD 7140811 rbsD Escherichia coli ED1a D-ribose pyranase YP_002400248.1 4370156 D 585397 CDS YP_002400249.1 218692037 7141259 4370583..4372088 1 NC_011745.1 with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain; D-ribose transporter ATP binding protein 4372088 rbsA 7141259 rbsA Escherichia coli ED1a D-ribose transporter ATP binding protein YP_002400249.1 4370583 D 585397 CDS YP_002400250.1 218692038 7141256 4372093..4373058 1 NC_011745.1 functions to transport ribose at high affinity; forms a complex with RbsA2C2B; ribose ABC transporter permease 4373058 rbsC 7141256 rbsC Escherichia coli ED1a ribose ABC transporter permease YP_002400250.1 4372093 D 585397 CDS YP_002400251.1 218692039 7141258 4373083..4373973 1 NC_011745.1 periplasmic substrate-binding component of the ATP-dependent ribose transport system; D-ribose transporter subunit RbsB 4373973 rbsB 7141258 rbsB Escherichia coli ED1a D-ribose transporter subunit RbsB YP_002400251.1 4373083 D 585397 CDS YP_002400252.1 218692040 7141257 4374099..4375028 1 NC_011745.1 catalyzes the formation of D-ribose 5-phosphate from ribose; ribokinase 4375028 rbsK 7141257 rbsK Escherichia coli ED1a ribokinase YP_002400252.1 4374099 D 585397 CDS YP_002400253.1 218692041 7141260 4375032..4376024 1 NC_011745.1 DNA-binding transcriptional repressor of ribose metabolism; transcriptional repressor RbsR 4376024 rbsR 7141260 rbsR Escherichia coli ED1a transcriptional repressor RbsR YP_002400253.1 4375032 D 585397 CDS YP_002400254.1 218692042 7141261 complement(4375990..4377417) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 20218988, 12107133; Product type t : transporter; multidrug or homocysteine efflux system 4377417 hsrA 7141261 hsrA Escherichia coli ED1a multidrug or homocysteine efflux system YP_002400254.1 4375990 R 585397 CDS YP_002400255.1 218692043 7140171 complement(4377440..4378132) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 4378132 yieP 7140171 yieP Escherichia coli ED1a putative transcriptional regulator YP_002400255.1 4377440 R 585397 CDS YP_002400256.1 218692044 7140582 complement(4383930..4384769) 1 NC_011745.1 Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon; transcriptional regulator HdfR 4384769 hdfR 7140582 hdfR Escherichia coli ED1a transcriptional regulator HdfR YP_002400256.1 4383930 R 585397 CDS YP_002400257.1 218692045 7139862 4384888..4385226 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4385226 yifE 7139862 yifE Escherichia coli ED1a hypothetical protein YP_002400257.1 4384888 D 585397 CDS YP_002400258.1 218692046 7139752 complement(4385251..4386801) 1 NC_011745.1 among the AAA+ ATPases, the YifB protease family belongs to the Helix 2 insert clade; unknown function; putative ATP-dependent protease 4386801 yifB 7139752 yifB Escherichia coli ED1a putative ATP-dependent protease YP_002400258.1 4385251 R 585397 CDS YP_002400259.1 218692047 7139751 4387124..4387222 1 NC_011745.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide; ilvG operon leader peptide 4387222 ilvL 7139751 ilvL Escherichia coli ED1a ilvG operon leader peptide YP_002400259.1 4387124 D 585397 CDS YP_002400260.1 218692048 7141705 4387362..4389008 1 NC_011745.1 catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; acetolactate synthase 2 catalytic subunit 4389008 ilvG 7141705 ilvG Escherichia coli ED1a acetolactate synthase 2 catalytic subunit YP_002400260.1 4387362 D 585397 CDS YP_002400261.1 218692049 7140240 4389005..4389268 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92332418, 92380929, 1569580, 3550695, 3897211; Product type e : enzyme; acetolactate synthase 2 regulatory subunit 4389268 ilvM 7140240 ilvM Escherichia coli ED1a acetolactate synthase 2 regulatory subunit YP_002400261.1 4389005 D 585397 CDS YP_002400262.1 218692050 7141104 4389288..4390217 1 NC_011745.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 4390217 ilvE 7141104 ilvE Escherichia coli ED1a branched-chain amino acid aminotransferase YP_002400262.1 4389288 D 585397 CDS YP_002400263.1 218692051 7140239 4390282..4392132 1 NC_011745.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 4392132 ilvD 7140239 ilvD Escherichia coli ED1a dihydroxy-acid dehydratase YP_002400263.1 4390282 D 585397 CDS YP_002400264.1 218692052 7140238 4392135..4393679 1 NC_011745.1 threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway; threonine dehydratase 4393679 ilvA 7140238 ilvA Escherichia coli ED1a threonine dehydratase YP_002400264.1 4392135 D 585397 CDS YP_002400265.1 218692053 7140235 complement(4393676..4394650) 1 NC_011745.1 participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate; DNA-binding transcriptional regulator IlvY 4394650 ilvY 7140235 ilvY Escherichia coli ED1a DNA-binding transcriptional regulator IlvY YP_002400265.1 4393676 R 585397 CDS YP_002400266.1 218692054 7141106 4394716..4396191 1 NC_011745.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 4396191 ilvC 7141106 ilvC Escherichia coli ED1a ketol-acid reductoisomerase YP_002400266.1 4394716 D 585397 CDS YP_002400267.1 218692055 7140237 complement(4396237..4396518) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94215709, 7878732, 7925971, 8163020; Product type e : enzyme; peptidyl-prolyl cis-trans isomerase C 4396518 ppiC 7140237 ppiC Escherichia coli ED1a peptidyl-prolyl cis-trans isomerase C YP_002400267.1 4396237 R 585397 CDS YP_002400268.1 218692056 7139105 4396605..4398626 1 NC_011745.1 single-stranded DNA-dependent ATPase; initiates unwinding at a nick in the DNA; involved in DNA replication; ATP-dependent DNA helicase Rep 4398626 rep 7139105 rep Escherichia coli ED1a ATP-dependent DNA helicase Rep YP_002400268.1 4396605 D 585397 CDS YP_002400269.1 218692057 7141589 complement(4398673..4400157) 1 NC_011745.1 catalyzes the conversion of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) to guanosine 5'-diphosphate,3'-diphosphate (ppGpp); pppGpp and ppGpp control the stringent response during amino acid starvation; guanosine pentaphosphate phosphohydrolase 4400157 gpp 7141589 gpp Escherichia coli ED1a guanosine pentaphosphate phosphohydrolase YP_002400269.1 4398673 R 585397 CDS YP_002400270.1 218692058 7143014 complement(4400163..4400342) 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 4400342 7143014 ECED1_4464 Escherichia coli ED1a hypothetical protein YP_002400270.1 4400163 R 585397 CDS YP_002400271.1 218692059 7142335 complement(4400293..4401558) 1 NC_011745.1 enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation; ATP-dependent RNA helicase RhlB 4401558 rhlB 7142335 rhlB Escherichia coli ED1a ATP-dependent RNA helicase RhlB YP_002400271.1 4400293 R 585397 CDS YP_002400272.1 218692060 7141613 4401689..4402018 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90202710, 91154193, 92250497, 99175138, 10489448, 1094461, 10947986, 1561103, 2181145, 2193685, 3891733, 4616096, 4883076, 6098320, 6099324, 7812718, 8098620, 8253691; Product type c : carrier; thioredoxin 4402018 trxA 7141613 trxA Escherichia coli ED1a thioredoxin YP_002400272.1 4401689 D 585397 CDS YP_002400273.1 218692061 7140831 4402159..4402260 1 NC_011745.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide; putative rho operon leader peptide 4402260 rhoL 7140831 rhoL Escherichia coli ED1a putative rho operon leader peptide YP_002400273.1 4402159 D 585397 CDS YP_002400274.1 218692062 7141616 4402345..4403604 1 NC_011745.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 4403604 rho 7141616 rho Escherichia coli ED1a transcription termination factor Rho YP_002400274.1 4402345 D 585397 CDS YP_002400275.1 218692063 7141615 4403844..4404947 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92114763, 94245613, 94292435, 10629198, 11024259, 11700352, 11832520, 1722555, 1730666; Product type e : enzyme; UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase 4404947 rfe 7141615 rfe Escherichia coli ED1a UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase YP_002400275.1 4403844 D 585397 CDS YP_002400276.1 218692064 7141598 4404959..4406005 1 NC_011745.1 Enterobacterial Common Antigen (ECA) polysaccharide chain length modulation protein; lipopolysaccharide biosynthesis protein WzzE 4406005 wzzE 7141598 wzzE Escherichia coli ED1a lipopolysaccharide biosynthesis protein WzzE YP_002400276.1 4404959 D 585397 CDS YP_002400277.1 218692065 7139196 4406061..4407191 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90212314, 90337949, 92112804, 94042873, 11106477, 7559340, 8170390, 8226648; Product type e : enzyme; UDP-N-acetyl glucosamine-2-epimerase 4407191 rffE 7139196 rffE Escherichia coli ED1a UDP-N-acetyl glucosamine-2-epimerase YP_002400277.1 4406061 D 585397 CDS YP_002400278.1 218692066 7141602 4407188..4408450 1 NC_011745.1 catalyzes the oxidation of UDP-N-acetyl-D-mannosamine to UDP-N-acetylmannosaminuronic acid; UDP-N-acetyl-D-mannosamine dehydrogenase 4408450 wecC 7141602 wecC Escherichia coli ED1a UDP-N-acetyl-D-mannosamine dehydrogenase YP_002400278.1 4407188 D 585397 CDS YP_002400279.1 218692067 7141601 4408450..4409517 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88086930, 90212314, 90337949, 92112804, 92174908, 94018634, 94042873, 7559340; Product type e : enzyme; dTDP-glucose 4,6-dehydratase 4409517 rffG 7141601 rffG Escherichia coli ED1a dTDP-glucose 4,6-dehydratase YP_002400279.1 4408450 D 585397 CDS YP_002400280.1 218692068 7141603 4409536..4410417 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94292435, 96032389; Product type e : enzyme; glucose-1-phosphate thymidylyltransferase 4410417 rffH 7141603 rffH Escherichia coli ED1a glucose-1-phosphate thymidylyltransferase YP_002400280.1 4409536 D 585397 CDS YP_002400281.1 218692069 7141604 4410395..4411069 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90212314, 90337949, 92112804, 8366065; Product type e : enzyme; TDP-fucosamine acetyltransferase 4411069 rffC 7141604 rffC Escherichia coli ED1a TDP-fucosamine acetyltransferase YP_002400281.1 4410395 D 585397 CDS YP_002400282.1 218692070 7141600 4411074..4412204 1 NC_011745.1 catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis; TDP-4-oxo-6-deoxy-D-glucose transaminase 4412204 rffA 7141600 rffA Escherichia coli ED1a TDP-4-oxo-6-deoxy-D-glucose transaminase YP_002400282.1 4411074 D 585397 CDS YP_002400283.1 218692071 7141599 4412206..4413456 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12621029, 20044778; Product type t : transporter; O-antigen translocase 4413456 wzxE 7141599 wzxE Escherichia coli ED1a O-antigen translocase YP_002400283.1 4412206 D 585397 CDS YP_002400284.1 218692072 7139194 4413453..4414532 1 NC_011745.1 catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis; 4-alpha-L-fucosyltransferase 4414532 rffT 7139194 rffT Escherichia coli ED1a 4-alpha-L-fucosyltransferase YP_002400284.1 4413453 D 585397 CDS YP_002400285.1 218692073 7141606 4414529..4415881 1 NC_011745.1 enterobacterial common antigen polymerase; putative common antigen polymerase 4415881 wzyE 7141606 wzyE Escherichia coli ED1a putative common antigen polymerase YP_002400285.1 4414529 D 585397 CDS YP_002400286.1 218692074 7139195 4415884..4416624 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88086874, 90337949, 92112804; Product type e : enzyme; putative UDP-N-acetyl-D-mannosaminuronic acid transferase 4416624 rffM 7139195 rffM Escherichia coli ED1a putative UDP-N-acetyl-D-mannosaminuronic acid transferase YP_002400286.1 4415884 D 585397 CDS YP_002400287.1 218692075 7141605 4416815..4418200 1 NC_011745.1 uncharacterized member of the amino acid-polyamine-organocation (APC) superfamily of amino acid transporters; unknown function; putative transport protein YifK 4418200 yifK 7141605 yifK Escherichia coli ED1a putative transport protein YifK YP_002400287.1 4416815 D 585397 CDS YP_002400288.1 218692076 7140587 4418886..4420121 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11222759, 2180918, 12419807, 14749327; Product type pr : putative regulator; regulator of arylsulfatase activity 4420121 aslB 7140587 aslB Escherichia coli ED1a regulator of arylsulfatase activity YP_002400288.1 4418886 D 585397 CDS YP_002400289.1 218692077 7142643 complement(4420212..4421867) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16766528, 92358234, 15477040; Product type e : enzyme; arylsulfatase-like enzyme 4421867 aslA 7142643 aslA Escherichia coli ED1a arylsulfatase-like enzyme YP_002400289.1 4420212 R 585397 CDS YP_002400290.1 218692078 7141353 complement(4422546..4423742) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 89041586; Product type pe : putative enzyme; putative protoheme IX biogenesis protein 4423742 hemY 7141353 hemY Escherichia coli ED1a putative protoheme IX biogenesis protein YP_002400290.1 4422546 R 585397 CDS YP_002400291.1 218692079 7139876 complement(4423745..4424962) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 89098348, 92358234, 3054815, 3062586, 9298646; Product type pe : putative enzyme; putative uroporphyrinogen III C-methyltransferase 4424962 hemX 7139876 hemX Escherichia coli ED1a putative uroporphyrinogen III C-methyltransferase YP_002400291.1 4423745 R 585397 CDS YP_002400292.1 218692080 7139875 complement(4424984..4425724) 1 NC_011745.1 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis; uroporphyrinogen-III synthase 4425724 hemD 7139875 hemD Escherichia coli ED1a uroporphyrinogen-III synthase YP_002400292.1 4424984 R 585397 CDS YP_002400293.1 218692081 7139868 complement(4425721..4426662) 1 NC_011745.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 4426662 hemC 7139868 hemC Escherichia coli ED1a porphobilinogen deaminase YP_002400293.1 4425721 R 585397 CDS YP_002400294.1 218692082 7139867 4427049..4429595 1 NC_011745.1 catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP; adenylate cyclase 4429595 cyaA 7139867 cyaA Escherichia coli ED1a adenylate cyclase YP_002400294.1 4427049 D 585397 CDS YP_002400295.1 218692083 7142093 complement(4429635..4429955) 1 NC_011745.1 defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly; frataxin-like protein 4429955 cyaY 7142093 cyaY Escherichia coli ED1a frataxin-like protein YP_002400295.1 4429635 R 585397 CDS YP_002400296.1 218692084 7142094 4430425..4430628 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; putative lipoprotein 4430628 yifL 7142094 yifL Escherichia coli ED1a putative lipoprotein YP_002400296.1 4430425 D 585397 CDS YP_002400297.1 218692085 7139754 4430665..4431489 1 NC_011745.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 4431489 dapF 7139754 dapF Escherichia coli ED1a diaminopimelate epimerase YP_002400297.1 4430665 D 585397 CDS YP_002400298.1 218692086 7143066 4431486..4432193 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4432193 yigA 7143066 yigA Escherichia coli ED1a hypothetical protein YP_002400298.1 4431486 D 585397 CDS YP_002400299.1 218692087 7142276 4432190..4433086 1 NC_011745.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC 4433086 xerC 7142276 xerC Escherichia coli ED1a site-specific tyrosine recombinase XerC YP_002400299.1 4432190 D 585397 CDS YP_002400300.1 218692088 7139206 4433086..4433802 1 NC_011745.1 YigB; member of the haloacid dehalogenase (HAD)-like hydrolases superfamily of protein; unknown function; flavin mononucleotide phosphatase 4433802 yigB 7139206 yigB Escherichia coli ED1a flavin mononucleotide phosphatase YP_002400300.1 4433086 D 585397 CDS YP_002400301.1 218692089 7142873 4433886..4436048 1 NC_011745.1 unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair.; DNA-dependent helicase II 4436048 uvrD 7142873 uvrD Escherichia coli ED1a DNA-dependent helicase II YP_002400301.1 4433886 D 585397 CDS YP_002400302.1 218692090 7139153 complement(4436103..4437005) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4437005 7139153 ECED1_4499 Escherichia coli ED1a hypothetical protein YP_002400302.1 4436103 R 585397 CDS YP_002400303.1 218692091 7142336 complement(4437088..4437852) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4437852 yigE 7142336 yigE Escherichia coli ED1a hypothetical protein YP_002400303.1 4437088 R 585397 CDS YP_002400304.1 218692092 7142874 4438222..4439172 1 NC_011745.1 responsible for the influx of magnesium ions; magnesium/nickel/cobalt transporter CorA 4439172 corA 7142874 corA Escherichia coli ED1a magnesium/nickel/cobalt transporter CorA YP_002400304.1 4438222 D 585397 CDS YP_002400305.1 218692093 7142040 complement(4439208..4439705) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4439705 7142040 ECED1_4502 Escherichia coli ED1a hypothetical protein YP_002400305.1 4439208 R 585397 CDS YP_002400306.1 218692094 7142337 complement(4439702..4440550) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4440550 7142337 ECED1_4503 Escherichia coli ED1a hypothetical protein YP_002400306.1 4439702 R 585397 CDS YP_002400307.1 218692095 7142338 complement(4440860..4441750) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative chloramphenicol resistance permease 4441750 rarD 7142338 rarD Escherichia coli ED1a putative chloramphenicol resistance permease YP_002400307.1 4440860 R 585397 CDS YP_002400308.1 218692096 7141251 complement(4441802..4442269) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4442269 yigI 7141251 yigI Escherichia coli ED1a hypothetical protein YP_002400308.1 4441802 R 585397 CDS YP_002400309.1 218692097 7142875 4442434..4443303 1 NC_011745.1 catalyzes the hydrolysis of phosphatidylcholine; phospholipase A 4443303 pldA 7142875 pldA Escherichia coli ED1a phospholipase A YP_002400309.1 4442434 D 585397 CDS YP_002400310.1 218692098 7139067 4443428..4445257 1 NC_011745.1 functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway; ATP-dependent DNA helicase RecQ 4445257 recQ 7139067 recQ Escherichia coli ED1a ATP-dependent DNA helicase RecQ YP_002400310.1 4443428 D 585397 CDS YP_002400311.1 218692099 7141583 4445321..4445941 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99313167, 10386596, 3027506; Product type t : transporter; threonine efflux system 4445941 rhtC 7141583 rhtC Escherichia coli ED1a threonine efflux system YP_002400311.1 4445321 D 585397 CDS YP_002400312.1 218692100 7141620 complement(4446002..4446622) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99313167, 10386596; Product type t : transporter; homoserine/homoserine lactone efflux protein 4446622 rhtB 7141620 rhtB Escherichia coli ED1a homoserine/homoserine lactone efflux protein YP_002400312.1 4446002 R 585397 CDS YP_002400313.1 218692101 7141619 4446733..4447755 1 NC_011745.1 lecithinase B; catalyzes the conversion of 1-lysophosphatidylcholine to glycerophosphocholine; can also hydrolyze 2-acyl glycerophosphoethanolamine and other substrates; lysophospholipase L2 4447755 pldB 7141619 pldB Escherichia coli ED1a lysophospholipase L2 YP_002400313.1 4446733 D 585397 CDS YP_002400314.1 218692102 7139068 4447763..4448563 1 NC_011745.1 purine and pyrimidine nucleotides are secondary substrates; yigL expression is regulated by heat shock, osmotic shock and starvation of glucose, phosphate or ammonium; putative sugar phosphatase 4448563 yigL 7139068 yigL Escherichia coli ED1a putative sugar phosphatase YP_002400314.1 4447763 D 585397 CDS YP_002400315.1 218692103 7142876 4448639..4449538 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4449538 yigM 7142876 yigM Escherichia coli ED1a hypothetical protein YP_002400315.1 4448639 D 585397 CDS YP_002400316.1 218692104 7142877 complement(4449426..4450379) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90384950, 96303520, 2205852, 2643109; Product type r : regulator; DNA-binding transcriptional activator, homocysteine-binding 4450379 metR 7142877 metR Escherichia coli ED1a DNA-binding transcriptional activator, homocysteine-binding YP_002400316.1 4449426 R 585397 CDS YP_002400317.1 218692105 7142262 4450497..4452758 1 NC_011745.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 4452758 metE 7142262 metE Escherichia coli ED1a 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase YP_002400317.1 4450497 D 585397 CDS YP_002400318.1 218692106 7142251 4453065..4453655 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4453655 7142251 ECED1_4515 Escherichia coli ED1a hypothetical protein YP_002400318.1 4453065 D 585397 CDS YP_002400319.1 218692107 7142339 4453697..4455205 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9200688; Product type t : transporter; fused glucose-specific PTS enzymes: IIBcomponent and IIC component 4455205 ptsG 7142339 ptsG Escherichia coli ED1a fused glucose-specific PTS enzymes: IIBcomponent and IIC component YP_002400319.1 4453697 D 585397 CDS YP_002400320.1 218692108 7141207 4455256..4457253 1 NC_011745.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 4457253 7141207 ECED1_4517 Escherichia coli ED1a transketolase YP_002400320.1 4455256 D 585397 CDS YP_002400321.1 218692109 7142340 complement(4457283..4458128) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4458128 7142340 ECED1_4518 Escherichia coli ED1a hypothetical protein YP_002400321.1 4457283 R 585397 CDS YP_002400322.1 218692110 7142341 complement(4458328..4459233) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcritional regulator 4459233 7142341 ECED1_4519 Escherichia coli ED1a putative transcritional regulator YP_002400322.1 4458328 R 585397 CDS YP_002400323.1 218692111 7142342 complement(4459311..4460534) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative permease 4460534 7142342 ECED1_4520 Escherichia coli ED1a putative permease YP_002400323.1 4459311 R 585397 CDS YP_002400324.1 218692112 7142343 complement(4460560..4460949) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4460949 7142343 ECED1_4521 Escherichia coli ED1a hypothetical protein YP_002400324.1 4460560 R 585397 CDS YP_002400325.1 218692113 7142344 complement(4460966..4461922) 1 NC_011745.1 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 4461922 7142344 ECED1_4522 Escherichia coli ED1a carbamate kinase YP_002400325.1 4460966 R 585397 CDS YP_002400326.1 218692114 7142345 complement(4461915..4463390) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4463390 7142345 ECED1_4523 Escherichia coli ED1a hypothetical protein YP_002400326.1 4461915 R 585397 CDS YP_002400327.1 218692115 7142346 complement(4463336..4464895) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative succinyl-CoA synthetase subunit alpha 4464895 7142346 ECED1_4524 Escherichia coli ED1a putative succinyl-CoA synthetase subunit alpha YP_002400327.1 4463336 R 585397 CDS YP_002400328.1 218692116 7142347 complement(4464990..4465850) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4465850 7142347 ECED1_4525 Escherichia coli ED1a hypothetical protein YP_002400328.1 4464990 R 585397 CDS YP_002400329.1 218692117 7142348 complement(4465856..4466524) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative Isochorismate hydrolase 4466524 7142348 ECED1_4526 Escherichia coli ED1a putative Isochorismate hydrolase YP_002400329.1 4465856 R 585397 CDS YP_002400330.1 218692118 7142349 complement(4466781..4467656) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12676709; Product type pe : putative enzyme; putative hydrolase 4467656 ysgA 7142349 ysgA Escherichia coli ED1a putative hydrolase YP_002400330.1 4466781 R 585397 CDS YP_002400331.1 218692119 7143254 4467846..4468616 1 NC_011745.1 catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway; uridine phosphorylase 4468616 udp 7143254 udp Escherichia coli ED1a uridine phosphorylase YP_002400331.1 4467846 D 585397 CDS YP_002400332.1 218692120 7140867 complement(4468651..4470141) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4470141 7140867 ECED1_4529 Escherichia coli ED1a hypothetical protein YP_002400332.1 4468651 R 585397 CDS YP_002400333.1 218692121 7142350 complement(4470154..4470663) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative permease subunit 4470663 7142350 ECED1_4530 Escherichia coli ED1a putative permease subunit YP_002400333.1 4470154 R 585397 CDS YP_002400334.1 218692122 7142351 complement(4470677..4471651) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative periplasmic binding protein 4471651 7142351 ECED1_4531 Escherichia coli ED1a putative periplasmic binding protein YP_002400334.1 4470677 R 585397 CDS YP_002400335.1 218692123 7142352 complement(4471676..4472305) 1 NC_011745.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-galactonate 6-phosphate; functions in galactonate metabolism; 2-dehydro-3-deoxy-6-phosphogalactonate aldolase 4472305 7142352 ECED1_4532 Escherichia coli ED1a 2-dehydro-3-deoxy-6-phosphogalactonate aldolase YP_002400335.1 4471676 R 585397 CDS YP_002400336.1 218692124 7142353 complement(4472295..4473299) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; acidic carbohydrate kinase 4473299 7142353 ECED1_4533 Escherichia coli ED1a acidic carbohydrate kinase YP_002400336.1 4472295 R 585397 CDS YP_002400337.1 218692125 7142354 complement(4473323..4474177) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 4474177 7142354 ECED1_4534 Escherichia coli ED1a putative transcriptional regulator YP_002400337.1 4473323 R 585397 CDS YP_002400338.1 218692126 7142355 4474307..4475734 1 NC_011745.1 YigN; nuclease that may cleave DNA structures arising during the recombination of short-inverted repeats and thereby prevents the inversion of the internal sequence; transcription is induced by DNA-damaging agents such as nalidixic acid or mitomycin C in a LexA-dependent manner; DNA recombination protein RmuC 4475734 rmuC 7142355 rmuC Escherichia coli ED1a DNA recombination protein RmuC YP_002400338.1 4474307 D 585397 CDS YP_002400339.1 218692127 7141429 4475829..4476584 1 NC_011745.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase 4476584 ubiE 7141429 ubiE Escherichia coli ED1a ubiquinone/menaquinone biosynthesis methyltransferase YP_002400339.1 4475829 D 585397 CDS YP_002400340.1 218692128 7140860 4476598..4477203 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4477203 yigP 7140860 yigP Escherichia coli ED1a hypothetical protein YP_002400340.1 4476598 D 585397 CDS YP_002400341.1 218692129 7142878 4477200..4478840 1 NC_011745.1 an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions; putative ubiquinone biosynthesis protein UbiB 4478840 ubiB 7142878 ubiB Escherichia coli ED1a putative ubiquinone biosynthesis protein UbiB YP_002400341.1 4477200 D 585397 CDS YP_002400342.1 218692130 7140857 4478919..4479188 1 NC_011745.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase protein A 4479188 tatA 7140857 tatA Escherichia coli ED1a twin arginine translocase protein A YP_002400342.1 4478919 D 585397 CDS YP_002400343.1 218692131 7141512 4479192..4479707 1 NC_011745.1 mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase 4479707 tatB 7141512 tatB Escherichia coli ED1a sec-independent translocase YP_002400343.1 4479192 D 585397 CDS YP_002400344.1 218692132 7141513 4479710..4480486 1 NC_011745.1 with TatABE forms the twin-arginine translocation complex which is involved in the transport of proteins across the cytoplasmic membrane; twin-arginine protein translocation system subunit TatC 4480486 tatC 7141513 tatC Escherichia coli ED1a twin-arginine protein translocation system subunit TatC YP_002400344.1 4479710 D 585397 CDS YP_002400345.1 218692133 7141514 4480528..4481310 1 NC_011745.1 magnesium dependent; not involved in the Sec-independent protein export system; DNase TatD 4481310 tatD 7141514 tatD Escherichia coli ED1a DNase TatD YP_002400345.1 4480528 D 585397 CDS YP_002400346.1 218692134 7141515 complement(4481307..4481795) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92011415, 92250420, 92261317, 1584020, 12007406; Product type r : regulator; transcriptional activator RfaH 4481795 rfaH 7141515 rfaH Escherichia coli ED1a transcriptional activator RfaH YP_002400346.1 4481307 R 585397 CDS YP_002400347.1 218692135 7141592 4481962..4483455 1 NC_011745.1 catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol; 3-octaprenyl-4-hydroxybenzoate decarboxylase 4483455 ubiD 7141592 ubiD Escherichia coli ED1a 3-octaprenyl-4-hydroxybenzoate decarboxylase YP_002400347.1 4481962 D 585397 CDS YP_002400348.1 218692136 7140859 4483501..4484202 1 NC_011745.1 NAD(P)H-flavin reductase; catalyzes the reversible oxidation/reduction of NAD(P) and flavine mononucleotide; in Salmonella and E. coli this protein also reduces aquacob(III)alamin to cob(II)alamin; FMN reductase 4484202 fre 7140859 fre Escherichia coli ED1a FMN reductase YP_002400348.1 4483501 D 585397 CDS YP_002400349.1 218692137 7142170 complement(4484484..4485647) 1 NC_011745.1 FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; 3-ketoacyl-CoA thiolase 4485647 fadA 7142170 fadA Escherichia coli ED1a 3-ketoacyl-CoA thiolase YP_002400349.1 4484484 R 585397 CDS YP_002400350.1 218692138 7144124 complement(4485657..4487846) 1 NC_011745.1 includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; multifunctional fatty acid oxidation complex subunit alpha 4487846 fadB 7144124 fadB Escherichia coli ED1a multifunctional fatty acid oxidation complex subunit alpha YP_002400350.1 4485657 R 585397 CDS YP_002400351.1 218692139 7144125 4488036..4489367 1 NC_011745.1 catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters; proline dipeptidase 4489367 pepQ 7144125 pepQ Escherichia coli ED1a proline dipeptidase YP_002400351.1 4488036 D 585397 CDS YP_002400352.1 218692140 7144064 4489367..4489981 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15103642; Product type pf : putative factor; hypothetical protein 4489981 yigZ 7144064 yigZ Escherichia coli ED1a hypothetical protein YP_002400352.1 4489367 D 585397 CDS YP_002400353.1 218692141 7142879 4490020..4491471 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91100357, 2243799, 7896723; Product type t : transporter; potassium transporter 4491471 trkH 7142879 trkH Escherichia coli ED1a potassium transporter YP_002400353.1 4490020 D 585397 CDS YP_002400354.1 218692142 7140812 4491483..4492028 1 NC_011745.1 catalyzes the oxidation of protoporphyrinogen IX to form protoporphyrin IX; protoporphyrinogen oxidase 4492028 hemG 7140812 hemG Escherichia coli ED1a protoporphyrinogen oxidase YP_002400354.1 4491483 D 585397 CDS YP_002400355.1 218692143 7140740 complement(4497608..4498120) 1 NC_011745.1 in Escherichia coli the MobB protein is not essential but has been found to interact with multiple proteins involved in the molybdopterin guanine dinucleotide cofactor biosynthesis pathway; molybdopterin-guanine dinucleotide biosynthesis protein B 4498120 mobB 7140740 mobB Escherichia coli ED1a molybdopterin-guanine dinucleotide biosynthesis protein B YP_002400355.1 4497608 R 585397 CDS YP_002400356.1 218692144 7139002 complement(4498117..4498701) 1 NC_011745.1 in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis; molybdopterin-guanine dinucleotide biosynthesis protein MobA 4498701 mobA 7139002 mobA Escherichia coli ED1a molybdopterin-guanine dinucleotide biosynthesis protein MobA YP_002400356.1 4498117 R 585397 CDS YP_002400357.1 218692145 7139001 4498771..4499040 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4499040 yihD 7139001 yihD Escherichia coli ED1a hypothetical protein YP_002400357.1 4498771 D 585397 CDS YP_002400358.1 218692146 7142881 4499117..4500103 1 NC_011745.1 catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages; serine/threonine protein kinase 4500103 yihE 7142881 yihE Escherichia coli ED1a serine/threonine protein kinase YP_002400358.1 4499117 D 585397 CDS YP_002400359.1 218692147 7142882 4500120..4500746 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12498799, 93264419, 94016574, 94206930, 99298180, 10210188, 1429594, 1740115, 1934062, 8413591, 8494885, 8521518, 9194175, 9298646, 9300489, 9572841, 9600841, 9655827; Product type e : enzyme; periplasmic protein disulfide isomerase I 4500746 dsbA 7142882 dsbA Escherichia coli ED1a periplasmic protein disulfide isomerase I YP_002400359.1 4500120 D 585397 CDS YP_002400360.1 218692148 7140521 4500901..4502331 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4502331 yihF 7140521 yihF Escherichia coli ED1a hypothetical protein YP_002400360.1 4500901 D 585397 CDS YP_002400361.1 218692149 7142883 complement(4502372..4503304) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acyltransferase 4503304 yihG 7142883 yihG Escherichia coli ED1a putative acyltransferase YP_002400361.1 4502372 R 585397 CDS YP_002400362.1 218692150 7142884 4503668..4506454 1 NC_011745.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 4506454 polA 7142884 polA Escherichia coli ED1a DNA polymerase I YP_002400362.1 4503668 D 585397 CDS YP_002400363.1 218692151 7143830 complement(4506836..4507432) 1 NC_011745.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 4507432 engB 7143830 engB Escherichia coli ED1a ribosome biogenesis GTP-binding protein YsxC YP_002400363.1 4506836 R 585397 CDS YP_002400364.1 218692152 7142077 4508050..4508559 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4508559 yihI 7142077 yihI Escherichia coli ED1a hypothetical protein YP_002400364.1 4508050 D 585397 CDS YP_002400365.1 218692153 7142885 4508748..4510121 1 NC_011745.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 4510121 hemN 7142885 hemN Escherichia coli ED1a coproporphyrinogen III oxidase YP_002400365.1 4508748 D 585397 CDS YP_002400366.1 218692154 7139874 complement(4510576..4511985) 1 NC_011745.1 response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes; interacts with sigma-54; nitrogen regulation protein NR(I) 4511985 glnG 7139874 glnG Escherichia coli ED1a nitrogen regulation protein NR(I) YP_002400366.1 4510576 R 585397 CDS YP_002400367.1 218692155 7142957 complement(4511997..4513046) 1 NC_011745.1 sensory histidine kinase in two-component regulatory system with GlnG; acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC by phosphorylation/dephosphorylation; nitrogen regulation protein NR(II) 4513046 glnL 7142957 glnL Escherichia coli ED1a nitrogen regulation protein NR(II) YP_002400367.1 4511997 R 585397 CDS YP_002400368.1 218692156 7142960 complement(4513220..4514629) 1 NC_011745.1 forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme; glutamine synthetase 4514629 glnA 7142960 glnA Escherichia coli ED1a glutamine synthetase YP_002400368.1 4513220 R 585397 CDS YP_002400369.1 218692157 7143195 complement(4514763..4514909) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4514909 7143195 ECED1_4572 Escherichia coli ED1a hypothetical protein YP_002400369.1 4514763 R 585397 CDS YP_002400370.1 218692158 7142356 4515002..4516825 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9642082, 7783627, 9298646, 9622352; Product type f : factor; GTP-binding protein 4516825 bipA 7142356 bipA Escherichia coli ED1a GTP-binding protein YP_002400370.1 4515002 D 585397 CDS YP_002400371.1 218692159 7140456 complement(4516927..4517619) 1 NC_011745.1 porin involved in the transport of small molecular weight solutes (up to 600 Daltons) across the cell wall; specific substrate still unknown; outer membrane porin L 4517619 ompL 7140456 ompL Escherichia coli ED1a outer membrane porin L YP_002400371.1 4516927 R 585397 CDS YP_002400372.1 218692160 7139971 complement(4517687..4519090) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 4519090 yihO 7139971 yihO Escherichia coli ED1a putative transporter YP_002400372.1 4517687 R 585397 CDS YP_002400373.1 218692161 7142886 complement(4519133..4520551) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 4520551 yihP 7142886 yihP Escherichia coli ED1a putative transporter YP_002400373.1 4519133 R 585397 CDS YP_002400374.1 218692162 7142887 complement(4520564..4522600) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15294295; Product type e : enzyme; alpha-glucosidase 4522600 yihQ 7142887 yihQ Escherichia coli ED1a alpha-glucosidase YP_002400374.1 4520564 R 585397 CDS YP_002400375.1 218692163 7142888 complement(4522706..4523581) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative permease 4523581 7142888 ECED1_4578 Escherichia coli ED1a putative permease YP_002400375.1 4522706 R 585397 CDS YP_002400376.1 218692164 7142357 complement(4523642..4524544) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative aldose-1-epimerase 4524544 yihR 7142357 yihR Escherichia coli ED1a putative aldose-1-epimerase YP_002400376.1 4523642 R 585397 CDS YP_002400377.1 218692165 7142889 complement(4524611..4525852) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glucosamine isomerase 4525852 yihS 7142889 yihS Escherichia coli ED1a putative glucosamine isomerase YP_002400377.1 4524611 R 585397 CDS YP_002400378.1 218692166 7142890 complement(4525868..4526746) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative aldolase 4526746 yihT 7142890 yihT Escherichia coli ED1a putative aldolase YP_002400378.1 4525868 R 585397 CDS YP_002400379.1 218692167 7142891 complement(4526770..4527666) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase with NAD(P)-binding Rossmann-fold domain 4527666 yihU 7142891 yihU Escherichia coli ED1a putative oxidoreductase with NAD(P)-binding Rossmann-fold domain YP_002400379.1 4526770 R 585397 CDS YP_002400380.1 218692168 7142892 4527834..4528730 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sugar kinase 4528730 yihV 7142892 yihV Escherichia coli ED1a putative sugar kinase YP_002400380.1 4527834 D 585397 CDS YP_002400381.1 218692169 7142893 4528764..4529549 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 4529549 yihW 7142893 yihW Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002400381.1 4528764 D 585397 CDS YP_002400382.1 218692170 7142894 4529648..4530247 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; phosphatase 4530247 yihX 7142894 yihX Escherichia coli ED1a phosphatase YP_002400382.1 4529648 D 585397 CDS YP_002400383.1 218692171 7142895 4530241..4531113 1 NC_011745.1 RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease; ribonuclease BN 4531113 rbn 7142895 rbn Escherichia coli ED1a ribonuclease BN YP_002400383.1 4530241 D 585397 CDS YP_002400384.1 218692172 7141255 4531110..4531547 1 NC_011745.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 4531547 dtd 7141255 dtd Escherichia coli ED1a D-tyrosyl-tRNA(Tyr) deacylase YP_002400384.1 4531110 D 585397 CDS YP_002400385.1 218692173 7140531 4531544..4532533 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acetyltransferase 4532533 yiiD 7140531 yiiD Escherichia coli ED1a putative acetyltransferase YP_002400385.1 4531544 D 585397 CDS YP_002400386.1 218692174 7142896 complement(4532597..4533580) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative lipase 4533580 7142896 ECED1_4589 Escherichia coli ED1a putative lipase YP_002400386.1 4532597 R 585397 CDS YP_002400387.1 218692175 7140488 4533734..4534045 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4534045 7140488 ECED1_4590 Escherichia coli ED1a hypothetical protein YP_002400387.1 4533734 D 585397 CDS YP_002400388.1 218692176 7143550 4534046..4534336 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative transcriptional regulator 4534336 7143550 ECED1_4591 Escherichia coli ED1a putative transcriptional regulator YP_002400388.1 4534046 D 585397 CDS YP_002400389.1 218692177 7143551 4534695..4534973 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4534973 7143551 ECED1_4592 Escherichia coli ED1a hypothetical protein YP_002400389.1 4534695 D 585397 CDS YP_002400390.1 218692178 7143552 4535369..4535587 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 4535587 yiiE 7143552 yiiE Escherichia coli ED1a putative transcriptional regulator YP_002400390.1 4535369 D 585397 CDS YP_002400391.1 218692179 7142897 complement(4535803..4536732) 1 NC_011745.1 required for the formation of active formate dehydrogenase; formate dehydrogenase accessory protein FdhE 4536732 fdhE 7142897 fdhE Escherichia coli ED1a formate dehydrogenase accessory protein FdhE YP_002400391.1 4535803 R 585397 CDS YP_002400392.1 218692180 7144137 complement(4536729..4537364) 1 NC_011745.1 cytochrome b556(FDO) component; heme containing; formate dehydrogenase-O subunit gamma 4537364 fdoI 7144137 fdoI Escherichia coli ED1a formate dehydrogenase-O subunit gamma YP_002400392.1 4536729 R 585397 CDS YP_002400393.1 218692181 7144144 complement(4537361..4538263) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91317715, 8522521, 9852007; Product type c : carrier; formate dehydrogenase-O, Fe-S subunit 4538263 fdoH 7144144 fdoH Escherichia coli ED1a formate dehydrogenase-O, Fe-S subunit YP_002400393.1 4537361 R 585397 CDS YP_002400394.1 218692182 7144143 complement(4538276..4541326) 1 NC_011745.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; formate dehydrogenase-O, large subunit 4541326 fdoG 7144143 fdoG Escherichia coli ED1a formate dehydrogenase-O, large subunit YP_002400394.1 4538276 R 585397 CDS YP_002400395.1 218692183 7144142 4541520..4542353 1 NC_011745.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth; formate dehydrogenase accessory protein 4542353 fdhD 7144142 fdhD Escherichia coli ED1a formate dehydrogenase accessory protein YP_002400395.1 4541520 D 585397 CDS YP_002400396.1 218692184 7144136 4542441..4542995 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4542995 7144136 ECED1_4600 Escherichia coli ED1a hypothetical protein YP_002400396.1 4542441 D 585397 CDS YP_002400397.1 218692185 7143553 4543349..4544743 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative glycoporin 4544743 7143553 ECED1_4601 Escherichia coli ED1a putative glycoporin YP_002400397.1 4543349 D 585397 CDS YP_002400398.1 218692186 7143554 complement(4544784..4545098) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15060078; Product type e : enzyme; L-rhamnose mutarotase 4545098 yiiL 7143554 yiiL Escherichia coli ED1a L-rhamnose mutarotase YP_002400398.1 4544784 R 585397 CDS YP_002400399.1 218692187 7142898 complement(4545108..4545932) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90128204, 93374854, 8396120; Product type e : enzyme; rhamnulose-1-phosphate aldolase 4545932 rhaD 7142898 rhaD Escherichia coli ED1a rhamnulose-1-phosphate aldolase YP_002400399.1 4545108 R 585397 CDS YP_002400400.1 218692188 7141609 complement(4546117..4547376) 1 NC_011745.1 catalyzes the formation of L-rhamnulose from L-rhamnose; L-rhamnose isomerase 4547376 rhaA 7141609 rhaA Escherichia coli ED1a L-rhamnose isomerase YP_002400400.1 4546117 R 585397 CDS YP_002400401.1 218692189 7141607 complement(4547373..4548842) 1 NC_011745.1 catalyzes the ATP-dependent phosphorylation of rhamnulose; rhamnulokinase 4548842 rhaB 7141607 rhaB Escherichia coli ED1a rhamnulokinase YP_002400401.1 4547373 R 585397 CDS YP_002400402.1 218692190 7141608 4549130..4549966 1 NC_011745.1 activates the expression of the rhaBAD operon and rhaT gene; transcriptional activator RhaS 4549966 rhaS 7141608 rhaS Escherichia coli ED1a transcriptional activator RhaS YP_002400402.1 4549130 D 585397 CDS YP_002400403.1 218692191 7141611 4549950..4550888 1 NC_011745.1 activates the expression of rhaRS in response to L-rhamnose; transcriptional activator RhaR 4550888 rhaR 7141611 rhaR Escherichia coli ED1a transcriptional activator RhaR YP_002400403.1 4549950 D 585397 CDS YP_002400404.1 218692192 7141610 complement(4550885..4551919) 1 NC_011745.1 transports L-rhamnose and L-lyxose into the cell; rhamnose-proton symporter 4551919 rhaT 7141610 rhaT Escherichia coli ED1a rhamnose-proton symporter YP_002400404.1 4550885 R 585397 CDS YP_002400405.1 218692193 7141612 4552205..4552825 1 NC_011745.1 SodA; manganese binding; only present under aerobic conditions; destroys free radicals; superoxide dismutase 4552825 sodA 7141612 sodA Escherichia coli ED1a superoxide dismutase YP_002400405.1 4552205 D 585397 CDS YP_002400406.1 218692194 7143814 4553043..4553987 1 NC_011745.1 transports degraded pectin products into the bacterial cell; 2-keto-3-deoxygluconate permease 4553987 kdgT 7143814 kdgT Escherichia coli ED1a 2-keto-3-deoxygluconate permease YP_002400406.1 4553043 D 585397 CDS YP_002400407.1 218692195 7142492 4554136..4554810 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4554810 yiiM 7142492 yiiM Escherichia coli ED1a hypothetical protein YP_002400407.1 4554136 D 585397 CDS YP_002400408.1 218692196 7142899 complement(4554981..4556354) 1 NC_011745.1 part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors; two-component sensor protein 4556354 cpxA 7142899 cpxA Escherichia coli ED1a two-component sensor protein YP_002400408.1 4554981 R 585397 CDS YP_002400409.1 218692197 7142045 complement(4556351..4557049) 1 NC_011745.1 response regulator in two-component regulatory system with CpxA; part of the envelope stress response system; DNA-binding transcriptional regulator CpxR 4557049 cpxR 7142045 cpxR Escherichia coli ED1a DNA-binding transcriptional regulator CpxR YP_002400409.1 4556351 R 585397 CDS YP_002400410.1 218692198 7142047 4557199..4557699 1 NC_011745.1 repressor of the Cpx envelope stress response pathway which occurs via periplasmic interactions with CpxA; CpxP is degraded by DegP protease especially in the presence of misfolded substrates; periplasmic repressor CpxP 4557699 cpxP 7142047 cpxP Escherichia coli ED1a periplasmic repressor CpxP YP_002400410.1 4557199 D 585397 CDS YP_002400411.1 218692199 7142046 4557848..4558750 1 NC_011745.1 member of cation diffusion facilitator family; CDF; membrane-bound; induced by both zinc and iron, but does not induce resistance to zinc; can transport zinc(II) in a proton-dependent manner; instead this protein induces iron resistance; forms dimers; ferrous iron efflux protein F 4558750 fieF 7142046 fieF Escherichia coli ED1a ferrous iron efflux protein F YP_002400411.1 4557848 D 585397 CDS YP_002400412.1 218692200 7144178 4558931..4559893 1 NC_011745.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 4559893 pfkA 7144178 pfkA Escherichia coli ED1a 6-phosphofructokinase YP_002400412.1 4558931 D 585397 CDS YP_002400413.1 218692201 7144067 4560213..4561202 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91161616, 2002055, 3158524, 8774726, 9298646; Product type t : transporter; sulfate transporter subunit 4561202 sbp 7144067 sbp Escherichia coli ED1a sulfate transporter subunit YP_002400413.1 4560213 D 585397 CDS YP_002400414.1 218692202 7141376 4561309..4562064 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86008270, 2995360, 3158524; Product type e : enzyme; CDP-diacylglycerol pyrophosphatase 4562064 cdh 7141376 cdh Escherichia coli ED1a CDP-diacylglycerol pyrophosphatase YP_002400414.1 4561309 D 585397 CDS YP_002400415.1 218692203 7139325 complement(4562119..4562886) 1 NC_011745.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 4562886 tpiA 7139325 tpiA Escherichia coli ED1a triosephosphate isomerase YP_002400415.1 4562119 R 585397 CDS YP_002400416.1 218692204 7140800 complement(4562994..4563593) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4563593 yiiQ 7140800 yiiQ Escherichia coli ED1a hypothetical protein YP_002400416.1 4562994 R 585397 CDS YP_002400417.1 218692205 7142900 4563694..4564134 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4564134 yiiR 7142900 yiiR Escherichia coli ED1a hypothetical protein YP_002400417.1 4563694 D 585397 CDS YP_002400418.1 218692206 7142901 4564346..4564645 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4564645 yiiS 7142901 yiiS Escherichia coli ED1a hypothetical protein YP_002400418.1 4564346 D 585397 CDS YP_002400419.1 218692207 7142902 4564672..4565100 1 NC_011745.1 with UspC and Usp E is involved in resistance to UV radiation; universal stress protein UspD 4565100 yiiT 7142902 yiiT Escherichia coli ED1a universal stress protein UspD YP_002400419.1 4564672 D 585397 CDS YP_002400420.1 218692208 7142903 complement(4565105..4565851) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93194782, 94092163, 95050480, 95362685, 1400248, 2834327, 7961651, 8449868, 9149148; Product type e : enzyme; ferredoxin-NADP reductase 4565851 fpr 7142903 fpr Escherichia coli ED1a ferredoxin-NADP reductase YP_002400420.1 4565105 R 585397 CDS YP_002400421.1 218692209 7142164 complement(4565948..4566958) 1 NC_011745.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II 4566958 glpX 7142164 glpX Escherichia coli ED1a fructose 1,6-bisphosphatase II YP_002400421.1 4565948 R 585397 CDS YP_002400422.1 218692210 7142977 complement(4567129..4568637) 1 NC_011745.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase 4568637 glpK 7142977 glpK Escherichia coli ED1a glycerol kinase YP_002400422.1 4567129 R 585397 CDS YP_002400423.1 218692211 7142973 complement(4568660..4569505) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12629974, 12948772, 14646142, 15004242, 90094250, 92210584, 11039922, 11101882, 11226336, 11964478, 1372899, 2544860, 6998951; Product type t : transporter; glycerol facilitator 4569505 glpF 7142973 glpF Escherichia coli ED1a glycerol facilitator YP_002400423.1 4568660 R 585397 CDS YP_002400424.1 218692212 7142971 4569930..4570175 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4570175 yiiU 7142971 yiiU Escherichia coli ED1a hypothetical protein YP_002400424.1 4569930 D 585397 CDS YP_002400425.1 218692213 7142904 complement(4570260..4570745) 1 NC_011745.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA 4570745 rraA 7142904 rraA Escherichia coli ED1a ribonuclease activity regulator protein RraA YP_002400425.1 4570260 R 585397 CDS YP_002400426.1 218692214 7140105 complement(4570838..4571764) 1 NC_011745.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase 4571764 menA 7140105 menA Escherichia coli ED1a 1,4-dihydroxy-2-naphthoate octaprenyltransferase YP_002400426.1 4570838 R 585397 CDS YP_002400427.1 218692215 7142241 complement(4571831..4573162) 1 NC_011745.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU 4573162 hslU 7142241 hslU Escherichia coli ED1a ATP-dependent protease ATP-binding subunit HslU YP_002400427.1 4571831 R 585397 CDS YP_002400428.1 218692216 7140169 complement(4573172..4573702) 1 NC_011745.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit 4573702 hslV 7140169 hslV Escherichia coli ED1a ATP-dependent protease peptidase subunit YP_002400428.1 4573172 R 585397 CDS YP_002400429.1 218692217 7140170 complement(4573795..4574754) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9282742, 93285993, 8509333; Product type cp : cell process; essential cell division protein FtsN 4574754 ftsN 7140170 ftsN Escherichia coli ED1a essential cell division protein FtsN YP_002400429.1 4573795 R 585397 CDS YP_002400430.1 218692218 7143118 complement(4574846..4575871) 1 NC_011745.1 negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins; DNA-binding transcriptional regulator CytR 4575871 cytR 7143118 cytR Escherichia coli ED1a DNA-binding transcriptional regulator CytR YP_002400430.1 4574846 R 585397 CDS YP_002400431.1 218692219 7143049 complement(4576027..4578225) 1 NC_011745.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 4578225 priA 7143049 priA Escherichia coli ED1a primosome assembly protein PriA YP_002400431.1 4576027 R 585397 CDS YP_002400432.1 218692220 7139119 4578428..4578640 1 NC_011745.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 4578640 rpmE 7139119 rpmE Escherichia coli ED1a 50S ribosomal protein L31 YP_002400432.1 4578428 D 585397 CDS YP_002400433.1 218692221 7141479 complement(4578701..4579309) 1 NC_011745.1 member of the NlpC/P60 superfamily of peptidases; putative peptidoglycan peptidase 4579309 yiiX 7141479 yiiX Escherichia coli ED1a putative peptidoglycan peptidase YP_002400433.1 4578701 R 585397 CDS YP_002400434.1 218692222 7142905 complement(4579369..4579824) 1 NC_011745.1 when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis; transcriptional repressor protein MetJ 4579824 metJ 7142905 metJ Escherichia coli ED1a transcriptional repressor protein MetJ YP_002400434.1 4579369 R 585397 CDS YP_002400435.1 218692223 7142256 4579963..4581123 1 NC_011745.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase 4581123 metB 7142256 metB Escherichia coli ED1a cystathionine gamma-synthase YP_002400435.1 4579963 D 585397 CDS YP_002400436.1 218692224 7142249 4581126..4583558 1 NC_011745.1 multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartate kinase II/homoserine dehydrogenase II 4583558 metL 7142249 metL Escherichia coli ED1a bifunctional aspartate kinase II/homoserine dehydrogenase II YP_002400436.1 4581126 D 585397 CDS YP_002400437.1 218692225 7142259 complement(4583776..4584636) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type m : membrane component; nucleoside channel phage T6/colicin K receptor 4584636 tsx 7142259 tsx Escherichia coli ED1a nucleoside channel phage T6/colicin K receptor YP_002400437.1 4583776 R 585397 CDS YP_002400438.1 218692226 7140838 complement(4584713..4586257) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative 5'-nucleotidase/2',3'-cyclic phosphodiesterase 4586257 7140838 ECED1_4645 Escherichia coli ED1a putative 5'-nucleotidase/2',3'-cyclic phosphodiesterase YP_002400438.1 4584713 R 585397 CDS YP_002400439.1 218692227 7143555 4586204..4587469 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphoesterase 4587469 7143555 ECED1_4646 Escherichia coli ED1a putative phosphoesterase YP_002400439.1 4586204 D 585397 CDS YP_002400440.1 218692228 7143556 4587851..4588741 1 NC_011745.1 MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor; 5,10-methylenetetrahydrofolate reductase 4588741 metF 7143556 metF Escherichia coli ED1a 5,10-methylenetetrahydrofolate reductase YP_002400440.1 4587851 D 585397 CDS YP_002400441.1 218692229 7142252 4589070..4591250 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90292022, 94209230, 3045098; Product type e : enzyme; catalase/hydroperoxidase HPI(I) 4591250 katG 7142252 katG Escherichia coli ED1a catalase/hydroperoxidase HPI(I) YP_002400441.1 4589070 D 585397 CDS YP_002400442.1 218692230 7142485 4591344..4592249 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative permease 4592249 yijE 7142485 yijE Escherichia coli ED1a putative permease YP_002400442.1 4591344 D 585397 CDS YP_002400443.1 218692231 7142907 complement(4592276..4592893) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4592893 yijF 7142907 yijF Escherichia coli ED1a hypothetical protein YP_002400443.1 4592276 R 585397 CDS YP_002400444.1 218692232 7142908 complement(4593169..4594272) 1 NC_011745.1 forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; glycerol dehydrogenase 4594272 gldA 7142908 gldA Escherichia coli ED1a glycerol dehydrogenase YP_002400444.1 4593169 R 585397 CDS YP_002400445.1 218692233 7143184 complement(4594283..4594945) 1 NC_011745.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 4594945 fsaB 7143184 fsaB Escherichia coli ED1a fructose-6-phosphate aldolase YP_002400445.1 4594283 R 585397 CDS YP_002400446.1 218692234 7142185 complement(4594957..4597458) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 95291446, 7773398; Product type t : transporter; fused putative PTS enzymes: Hpr component ; enzyme I component ; enzyme IIA component 4597458 ptsA 7142185 ptsA Escherichia coli ED1a fused putative PTS enzymes: Hpr component ; enzyme I component ; enzyme IIA component YP_002400446.1 4594957 R 585397 CDS YP_002400447.1 218692235 7141205 4597767..4598846 1 NC_011745.1 FrwC with FrwB, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; forms translocation channel and contains the specific substrate-binding site; putative fructose-like permease EIIC subunit 2 4598846 frwC 7141205 frwC Escherichia coli ED1a putative fructose-like permease EIIC subunit 2 YP_002400447.1 4597767 D 585397 CDS YP_002400448.1 218692236 7142182 4598861..4599181 1 NC_011745.1 FrwB with FrwC, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system (PTS) permease which may phosphorylate and transport sugars into the cell; cytoplasmic protein that interacts with complex EIIA; contains the second phosphorylation site of the PTS; putative PTS system fructose-like transporter subunit EIIB 4599181 frwB 7142182 frwB Escherichia coli ED1a putative PTS system fructose-like transporter subunit EIIB YP_002400448.1 4598861 D 585397 CDS YP_002400449.1 218692237 7142181 4599232..4601529 1 NC_011745.1 involved in production of D-lactate from glucose under microaerobic conditions; cytoplasmic protein; putative formate acetyltransferase 2 4601529 pflD 7142181 pflD Escherichia coli ED1a putative formate acetyltransferase 2 YP_002400449.1 4599232 D 585397 CDS YP_002400450.1 218692238 7144072 4601495..4602373 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95291446, 14673546, 7773398; Product type e : enzyme; pyruvate formate lyase II activase 4602373 pflC 7144072 pflC Escherichia coli ED1a pyruvate formate lyase II activase YP_002400450.1 4601495 D 585397 CDS YP_002400451.1 218692239 7144071 4602375..4602716 1 NC_011745.1 FrwD with FrwB, FrwC and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; phosphorylated by EIIA; FrwB homolog; putative fructose-like phosphotransferase EIIB subunit 3 4602716 frwD 7144071 frwD Escherichia coli ED1a putative fructose-like phosphotransferase EIIB subunit 3 YP_002400451.1 4602375 D 585397 CDS YP_002400452.1 218692240 7142183 complement(4602703..4603554) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 4603554 yijO 7142183 yijO Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002400452.1 4602703 R 585397 CDS YP_002400453.1 218692241 7142909 complement(4603780..4605513) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10456927; Product type pm : putative membrane component; hypothetical protein 4605513 yijP 7142909 yijP Escherichia coli ED1a hypothetical protein YP_002400453.1 4603780 R 585397 CDS YP_002400454.1 218692242 7142910 complement(4605696..4608347) 1 NC_011745.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 4608347 ppc 7142910 ppc Escherichia coli ED1a phosphoenolpyruvate carboxylase YP_002400454.1 4605696 R 585397 CDS YP_002400455.1 218692243 7139096 complement(4608649..4609800) 1 NC_011745.1 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis; acetylornithine deacetylase 4609800 argE 7139096 argE Escherichia coli ED1a acetylornithine deacetylase YP_002400455.1 4608649 R 585397 CDS YP_002400456.1 218692244 7142613 4609954..4610958 1 NC_011745.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase 4610958 argC 7142613 argC Escherichia coli ED1a N-acetyl-gamma-glutamyl-phosphate reductase YP_002400456.1 4609954 D 585397 CDS YP_002400457.1 218692245 7142611 4610969..4611742 1 NC_011745.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 4611742 argB 7142611 argB Escherichia coli ED1a acetylglutamate kinase YP_002400457.1 4610969 D 585397 CDS YP_002400458.1 218692246 7142610 4611803..4613176 1 NC_011745.1 catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 4613176 argH 7142610 argH Escherichia coli ED1a argininosuccinate lyase YP_002400458.1 4611803 D 585397 CDS YP_002400459.1 218692247 7142615 4613614..4614888 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 93341455, 94310441; Product type pe : putative enzyme; putative enolase/dehydratase 4614888 rspA 7142615 rspA Escherichia coli ED1a putative enolase/dehydratase YP_002400459.1 4613614 D 585397 CDS YP_002400460.1 218692248 7140117 4614955..4616238 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 4616238 7140117 ECED1_4667 Escherichia coli ED1a putative transporter YP_002400460.1 4614955 D 585397 CDS YP_002400461.1 218692249 7139995 4616490..4617407 1 NC_011745.1 Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA; DNA-binding transcriptional regulator OxyR 4617407 oxyR 7139995 oxyR Escherichia coli ED1a DNA-binding transcriptional regulator OxyR YP_002400461.1 4616490 D 585397 CDS YP_002400462.1 218692250 7139994 complement(4617390..4618790) 1 NC_011745.1 catalyzes the conversion of NADPH to NADH; soluble pyridine nucleotide transhydrogenase 4618790 sthA 7139994 sthA Escherichia coli ED1a soluble pyridine nucleotide transhydrogenase YP_002400462.1 4617390 R 585397 CDS YP_002400463.1 218692251 7143861 4619120..4620265 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7730270; Product type e : enzyme; hippurate hydrolase 4620265 7143861 ECED1_4670 Escherichia coli ED1a hippurate hydrolase YP_002400463.1 4619120 D 585397 CDS YP_002400464.1 218692252 7143558 4620308..4621624 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative proton/ carboxylic acid permease 4621624 7143558 ECED1_4671 Escherichia coli ED1a putative proton/ carboxylic acid permease YP_002400464.1 4620308 D 585397 CDS YP_002400465.1 218692253 7143559 4621674..4622378 1 NC_011745.1 negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis; DNA-binding transcriptional repressor FabR 4622378 fabR 7143559 fabR Escherichia coli ED1a DNA-binding transcriptional repressor FabR YP_002400465.1 4621674 D 585397 CDS YP_002400466.1 218692254 7144122 4622378..4622737 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4622737 yijD 7144122 yijD Escherichia coli ED1a hypothetical protein YP_002400466.1 4622378 D 585397 CDS YP_002400467.1 218692255 7142906 complement(4622777..4623877) 1 NC_011745.1 catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs; tRNA (uracil-5-)-methyltransferase 4623877 trmA 7142906 trmA Escherichia coli ED1a tRNA (uracil-5-)-methyltransferase YP_002400467.1 4622777 R 585397 CDS YP_002400468.2 229598867 7140768 4624246..4626084 1 NC_011745.1 involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space; vitamin B12/cobalamin outer membrane transporter 4626084 btuB 7140768 btuB Escherichia coli ED1a vitamin B12/cobalamin outer membrane transporter YP_002400468.2 4624246 D 585397 CDS YP_002400469.1 218692257 7143560 4626029..4626886 1 NC_011745.1 converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 4626886 murI 7143560 murI Escherichia coli ED1a glutamate racemase YP_002400469.1 4626029 D 585397 CDS YP_002400470.1 218692258 7140741 4632408..4633436 1 NC_011745.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 4633436 murB 7140741 murB Escherichia coli ED1a UDP-N-acetylenolpyruvoylglucosamine reductase YP_002400470.1 4632408 D 585397 CDS YP_002400471.1 218692259 7139046 4633433..4634398 1 NC_011745.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 4634398 birA 7139046 birA Escherichia coli ED1a biotin--protein ligase YP_002400471.1 4633433 D 585397 CDS YP_002400472.1 218692260 7140457 complement(4634427..4635377) 1 NC_011745.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 4635377 coaA 7140457 coaA Escherichia coli ED1a pantothenate kinase YP_002400472.1 4634427 R 585397 CDS YP_002400473.1 218692261 7140595 4636295..4637479 1 NC_011745.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 4637479 tufB 7140595 tufB Escherichia coli ED1a elongation factor Tu YP_002400473.1 4636295 D 585397 CDS YP_002400474.1 218692262 7140843 4637709..4638092 1 NC_011745.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 4638092 secE 7140843 secE Escherichia coli ED1a preprotein translocase subunit SecE YP_002400474.1 4637709 D 585397 CDS YP_002400475.1 218692263 7141388 4638094..4638639 1 NC_011745.1 Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 4638639 nusG 7141388 nusG Escherichia coli ED1a transcription antitermination protein NusG YP_002400475.1 4638094 D 585397 CDS YP_002400476.1 218692264 7139961 4638798..4639226 1 NC_011745.1 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 4639226 rplK 7139961 rplK Escherichia coli ED1a 50S ribosomal protein L11 YP_002400476.1 4638798 D 585397 CDS YP_002400477.1 218692265 7141460 4639230..4639934 1 NC_011745.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 4639934 rplA 7141460 rplA Escherichia coli ED1a 50S ribosomal protein L1 YP_002400477.1 4639230 D 585397 CDS YP_002400478.1 218692266 7141452 4640226..4640723 1 NC_011745.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 4640723 rplJ 7141452 rplJ Escherichia coli ED1a 50S ribosomal protein L10 YP_002400478.1 4640226 D 585397 CDS YP_002400479.1 218692267 7141459 4640790..4641155 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90094251, 92210551, 10094780, 3309338, 377281, 4573678, 773698, 8603708, 9298646, 9515737, 9600841, 9868784; Product type s : structure; 50S ribosomal subunit protein L7/L12 4641155 rplL 7141459 rplL Escherichia coli ED1a 50S ribosomal subunit protein L7/L12 YP_002400479.1 4640790 D 585397 CDS YP_002400480.1 218692268 7141461 4641475..4645503 1 NC_011745.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 4645503 rpoB 7141461 rpoB Escherichia coli ED1a DNA-directed RNA polymerase subunit beta YP_002400480.1 4641475 D 585397 CDS YP_002400481.1 218692269 7141485 4645580..4649803 1 NC_011745.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 4649803 rpoC 7141485 rpoC Escherichia coli ED1a DNA-directed RNA polymerase subunit beta' YP_002400481.1 4645580 D 585397 CDS YP_002400482.1 218692270 7141486 complement(4650045..4651178) 1 NC_011745.1 in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center; thiamine biosynthesis protein ThiH 4651178 thiH 7141486 thiH Escherichia coli ED1a thiamine biosynthesis protein ThiH YP_002400482.1 4650045 R 585397 CDS YP_002400483.1 218692271 7141544 complement(4651175..4651945) 1 NC_011745.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase 4651945 thiG 7141544 thiG Escherichia coli ED1a thiazole synthase YP_002400483.1 4651175 R 585397 CDS YP_002400484.1 218692272 7141543 complement(4651947..4652147) 1 NC_011745.1 with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate; sulfur carrier protein ThiS 4652147 thiS 7141543 thiS Escherichia coli ED1a sulfur carrier protein ThiS YP_002400484.1 4651947 R 585397 CDS YP_002400485.1 218692273 7141550 complement(4652131..4652886) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8432721, 94089392, 98298179, 10082377, 9632726; Product type e : enzyme; thiamin (thiazole moiety) biosynthesis protein 4652886 thiF 7141550 thiF Escherichia coli ED1a thiamin (thiazole moiety) biosynthesis protein YP_002400485.1 4652131 R 585397 CDS YP_002400486.1 218692274 7141542 complement(4652879..4653514) 1 NC_011745.1 catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate; thiamine-phosphate pyrophosphorylase 4653514 thiE 7141542 thiE Escherichia coli ED1a thiamine-phosphate pyrophosphorylase YP_002400486.1 4652879 R 585397 CDS YP_002400487.1 218692275 7141541 complement(4653514..4655409) 1 NC_011745.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC 4655409 thiC 7141541 thiC Escherichia coli ED1a thiamine biosynthesis protein ThiC YP_002400487.1 4653514 R 585397 CDS YP_002400488.1 218692276 7140769 complement(4655642..4656118) 1 NC_011745.1 binds specifically to the major sigma factor sigma 70; active in stationary phase; anti-RNA polymerase sigma 70 factor 4656118 rsd 7140769 rsd Escherichia coli ED1a anti-RNA polymerase sigma 70 factor YP_002400488.1 4655642 R 585397 CDS YP_002400489.1 218692277 7140108 4656213..4656986 1 NC_011745.1 can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates; NADH pyrophosphatase 4656986 nudC 7140108 nudC Escherichia coli ED1a NADH pyrophosphatase YP_002400489.1 4656213 D 585397 CDS YP_002400490.1 218692278 7139938 4657026..4658090 1 NC_011745.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 4658090 hemE 7139938 hemE Escherichia coli ED1a uroporphyrinogen decarboxylase YP_002400490.1 4657026 D 585397 CDS YP_002400491.1 218692279 7139869 4658100..4658771 1 NC_011745.1 Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA; cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures; endonuclease V 4658771 nfi 7139869 nfi Escherichia coli ED1a endonuclease V YP_002400491.1 4658100 D 585397 CDS YP_002400492.1 218692280 7140375 4658814..4659404 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4659404 yjaG 7140375 yjaG Escherichia coli ED1a hypothetical protein YP_002400492.1 4658814 D 585397 CDS YP_002400493.1 218692281 7142913 4659591..4659863 1 NC_011745.1 histone-like DNA-binding protein; transcriptional regulator HU subunit alpha 4659863 hupA 7142913 hupA Escherichia coli ED1a transcriptional regulator HU subunit alpha YP_002400493.1 4659591 D 585397 CDS YP_002400494.1 218692282 7140178 4659876..4660571 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4660571 yjaH 7140178 yjaH Escherichia coli ED1a hypothetical protein YP_002400494.1 4659876 D 585397 CDS YP_002400495.1 218692283 7142914 complement(4660573..4661133) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98362023, 9694902; Product type pf : putative factor; zinc resistance protein 4661133 zraP 7142914 zraP Escherichia coli ED1a zinc resistance protein YP_002400495.1 4660573 R 585397 CDS YP_002400496.1 218692284 7143281 4661230..4662606 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21140164, 89327164, 92255260, 11243806, 2666400; Product type r : regulator; sensor protein ZraS 4662606 zraS 7143281 zraS Escherichia coli ED1a sensor protein ZraS YP_002400496.1 4661230 D 585397 CDS YP_002400497.1 218692285 7143197 4662603..4663928 1 NC_011745.1 DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein; transcriptional regulatory protein ZraR 4663928 zraR 7143197 zraR Escherichia coli ED1a transcriptional regulatory protein ZraR YP_002400497.1 4662603 D 585397 CDS YP_002400498.1 218692286 7142955 complement(4663925..4665214) 1 NC_011745.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 4665214 purD 7142955 purD Escherichia coli ED1a phosphoribosylamine--glycine ligase YP_002400498.1 4663925 R 585397 CDS YP_002400499.1 218692287 7141216 complement(4665226..4666815) 1 NC_011745.1 involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 4666815 purH 7141216 purH Escherichia coli ED1a bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase YP_002400499.1 4665226 R 585397 CDS YP_002400500.1 218692288 7140742 4672518..4672901 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2412207; hypothetical protein 4672901 yjaA 7140742 yjaA Escherichia coli ED1a hypothetical protein YP_002400500.1 4672518 D 585397 CDS YP_002400501.1 218692289 7142911 complement(4672964..4673407) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; hypothetical protein 4673407 yjaB 7142911 yjaB Escherichia coli ED1a hypothetical protein YP_002400501.1 4672964 R 585397 CDS YP_002400502.1 218692290 7142912 4673564..4674493 1 NC_011745.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase 4674493 metA 7142912 metA Escherichia coli ED1a homoserine O-succinyltransferase YP_002400502.1 4673564 D 585397 CDS YP_002400503.1 218692291 7142248 4674762..4676363 1 NC_011745.1 Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle; malate synthase 4676363 aceB 7142248 aceB Escherichia coli ED1a malate synthase YP_002400503.1 4674762 D 585397 CDS YP_002400504.1 218692292 7143637 4676393..4677697 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91295197, 92112731, 92353108, 2836370, 3049537, 3060852, 3276689, 3290857, 3291954, 7826335; Product type e : enzyme; isocitrate lyase 4677697 aceA 7143637 aceA Escherichia coli ED1a isocitrate lyase YP_002400504.1 4676393 D 585397 CDS YP_002400505.1 218692293 7143636 4677913..4679637 1 NC_011745.1 catalyzes the phosphorylation/dephosphorylation of the enzyme isocitrate dehydrogenase on a specific serine which regulates activity; unphosphorylated IDH is fully active when cells are grown on glucose while the enzyme becomes phosphorylated and inactive in the presence of acetate or ethanol; bifunctional isocitrate dehydrogenase kinase/phosphatase protein 4679637 aceK 7143636 aceK Escherichia coli ED1a bifunctional isocitrate dehydrogenase kinase/phosphatase protein YP_002400505.1 4677913 D 585397 CDS YP_002400506.1 218692294 7143640 complement(4679654..4680478) 1 NC_011745.1 regulates the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase and isocitrate dehydrogenase kinase/phosphorylase; transcriptional repressor IclR 4680478 iclR 7143640 iclR Escherichia coli ED1a transcriptional repressor IclR YP_002400506.1 4679654 R 585397 CDS YP_002400507.1 218692295 7140223 4680678..4684361 1 NC_011745.1 one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity; B12-dependent methionine synthase 4684361 metH 7140223 metH Escherichia coli ED1a B12-dependent methionine synthase YP_002400507.1 4680678 D 585397 CDS YP_002400508.1 218692296 7142254 4684415..4684741 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4684741 7142254 ECED1_4726 Escherichia coli ED1a hypothetical protein YP_002400508.1 4684415 D 585397 CDS YP_002400509.1 218692297 7143561 4684784..4685233 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4685233 7143561 ECED1_4727 Escherichia coli ED1a hypothetical protein YP_002400509.1 4684784 D 585397 CDS YP_002400510.1 218692298 7143562 4685404..4687035 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 4687035 yjbB 7143562 yjbB Escherichia coli ED1a putative transporter YP_002400510.1 4685404 D 585397 CDS YP_002400511.1 218692299 7142916 complement(4687125..4687814) 1 NC_011745.1 alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family; peptidase E 4687814 pepE 7142916 pepE Escherichia coli ED1a peptidase E YP_002400511.1 4687125 R 585397 CDS YP_002400512.1 218692300 7144061 complement(4688196..4689437) 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7947968, 7652212; Product type e : enzyme; L-sorbose 1-phosphate reductase 4689437 7144061 ECED1_4730 Escherichia coli ED1a L-sorbose 1-phosphate reductase YP_002400512.1 4688196 R 585397 CDS YP_002400513.1 218692301 7143563 complement(4689477..4690331) 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7947968, 7700234; Product type t : transporter; sorbose permease IID component 4690331 7143563 ECED1_4731 Escherichia coli ED1a sorbose permease IID component YP_002400513.1 4689477 R 585397 CDS YP_002400514.1 218692302 7143564 complement(4690312..4691109) 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7947968, 7700234; Product type t : transporter; sorbose permease IIC component (PTS system) 4691109 7143564 ECED1_4732 Escherichia coli ED1a sorbose permease IIC component (PTS system) YP_002400514.1 4690312 R 585397 CDS YP_002400515.1 218692303 7143565 complement(4691175..4691669) 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7947968, 7700234, 12662934; Product type t : transporter; sorbose-specific phosphotransferase enzyme IIB component (PTS system) 4691669 7143565 ECED1_4733 Escherichia coli ED1a sorbose-specific phosphotransferase enzyme IIB component (PTS system) YP_002400515.1 4691175 R 585397 CDS YP_002400516.1 218692304 7143566 complement(4691669..4692076) 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7947968; Product type t : transporter; sorbose-specific phosphotransferase enzyme IIA component (PTS system) 4692076 7143566 ECED1_4734 Escherichia coli ED1a sorbose-specific phosphotransferase enzyme IIA component (PTS system) YP_002400516.1 4691669 R 585397 CDS YP_002400517.1 218692305 7143567 complement(4692086..4692892) 1 NC_011745.1 Converts D-sorbitol-dphosphate to D-fructose-6-phosphate; sorbitol-6-phosphate 2-dehydrogenase 4692892 7143567 ECED1_4735 Escherichia coli ED1a sorbitol-6-phosphate 2-dehydrogenase YP_002400517.1 4692086 R 585397 CDS YP_002400518.1 218692306 7143568 complement(4692962..4693993) 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7947968; Product type r : regulator; sorbitol/sorbose operon activator 4693993 7143568 ECED1_4736 Escherichia coli ED1a sorbitol/sorbose operon activator YP_002400518.1 4692962 R 585397 CDS YP_002400519.1 218692307 7143569 4694257..4695129 1 NC_011745.1 catalyzes the synthesis of pseudouridine from U-2604 in the 23S ribosomal RNA; 23S rRNA pseudouridine synthase F 4695129 yjbC 7143569 yjbC Escherichia coli ED1a 23S rRNA pseudouridine synthase F YP_002400519.1 4694257 D 585397 CDS YP_002400520.1 218692308 7142917 complement(4695130..4695402) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4695402 yjbD 7142917 yjbD Escherichia coli ED1a hypothetical protein YP_002400520.1 4695130 R 585397 CDS YP_002400521.1 218692309 7142918 complement(4695655..4697004) 1 NC_011745.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive; aspartate kinase III 4697004 lysC 7142918 lysC Escherichia coli ED1a aspartate kinase III YP_002400521.1 4695655 R 585397 CDS YP_002400522.1 218692310 7140770 4697529..4699178 1 NC_011745.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 4699178 pgi 7140770 pgi Escherichia coli ED1a glucose-6-phosphate isomerase YP_002400522.1 4697529 D 585397 CDS YP_002400523.1 218692311 7144074 complement(4699657..4699986) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4699986 7144074 ECED1_4741 Escherichia coli ED1a hypothetical protein YP_002400523.1 4699657 R 585397 CDS YP_002400524.1 218692312 7143570 4700105..4700743 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; putative lipoprotein 4700743 yjbF 7143570 yjbF Escherichia coli ED1a putative lipoprotein YP_002400524.1 4700105 D 585397 CDS YP_002400525.1 218692313 7142919 4700740..4701477 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4701477 yjbG 7142919 yjbG Escherichia coli ED1a hypothetical protein YP_002400525.1 4700740 D 585397 CDS YP_002400526.1 218692314 7142920 4701477..4703573 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative porin 4703573 yjbH 7142920 yjbH Escherichia coli ED1a putative porin YP_002400526.1 4701477 D 585397 CDS YP_002400527.1 218692315 7142921 4703577..4703738 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 4703738 7142921 ECED1_4745 Escherichia coli ED1a hypothetical protein YP_002400527.1 4703577 D 585397 CDS YP_002400528.1 218692316 7143571 complement(4703620..4703898) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4703898 7143571 ECED1_4746 Escherichia coli ED1a hypothetical protein YP_002400528.1 4703620 R 585397 CDS YP_002400529.1 218692317 7143572 4704113..4704523 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10986267; Product type pm : putative membrane component; phosphate-starvation-inducible protein PsiE 4704523 yjbA 7143572 yjbA Escherichia coli ED1a phosphate-starvation-inducible protein PsiE YP_002400529.1 4704113 D 585397 CDS YP_002400530.1 218692318 7142915 complement(4704617..4705507) 1 NC_011745.1 with MalKFE is involved in the transport of maltose into the cell; maltose transporter permease 4705507 malG 7142915 malG Escherichia coli ED1a maltose transporter permease YP_002400530.1 4704617 R 585397 CDS YP_002400531.1 218692319 7142196 complement(4705522..4707066) 1 NC_011745.1 with MalKGE is involved in maltose transport into the cell; maltose transporter membrane protein 4707066 malF 7142196 malF Escherichia coli ED1a maltose transporter membrane protein YP_002400531.1 4705522 R 585397 CDS YP_002400532.1 218692320 7142195 complement(4707220..4708410) 1 NC_011745.1 functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis; maltose ABC transporter periplasmic protein 4708410 malE 7142195 malE Escherichia coli ED1a maltose ABC transporter periplasmic protein YP_002400532.1 4707220 R 585397 CDS YP_002400533.1 218692321 7142359 4708775..4709890 1 NC_011745.1 with malEFG is involved in import of maltose/maltodextrin; maltose/maltodextrin transporter ATP-binding protein 4709890 malK 7142359 malK Escherichia coli ED1a maltose/maltodextrin transporter ATP-binding protein YP_002400533.1 4708775 D 585397 CDS YP_002400534.1 218692322 7142198 4709962..4711302 1 NC_011745.1 porin involved in the transport of maltose and maltodextrins; maltoporin 4711302 lamB 7142198 lamB Escherichia coli ED1a maltoporin YP_002400534.1 4709962 D 585397 CDS YP_002400535.1 218692323 7141868 4711534..4712454 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87141162, 2434655, 6086106; Product type pt : putative transporter; maltose regulon periplasmic protein 4712454 malM 7141868 malM Escherichia coli ED1a maltose regulon periplasmic protein YP_002400535.1 4711534 D 585397 CDS YP_002400536.1 218692324 7142199 4712633..4713130 1 NC_011745.1 catalyzes the formation of 4-hydroxybenzoate from chorismate; chorismate pyruvate lyase 4713130 ubiC 7142199 ubiC Escherichia coli ED1a chorismate pyruvate lyase YP_002400536.1 4712633 D 585397 CDS YP_002400537.1 218692325 7140858 4713143..4714015 1 NC_011745.1 catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway; 4-hydroxybenzoate octaprenyltransferase 4714015 ubiA 7140858 ubiA Escherichia coli ED1a 4-hydroxybenzoate octaprenyltransferase YP_002400537.1 4713143 D 585397 CDS YP_002400538.1 218692326 7140856 complement(4714170..4716593) 1 NC_011745.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase 4716593 plsB 7140856 plsB Escherichia coli ED1a glycerol-3-phosphate acyltransferase YP_002400538.1 4714170 R 585397 CDS YP_002400539.1 218692327 7139069 4716764..4717132 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10220339, 6257698, 86278195, 88111690, 2984194, 6309817, 8071224; Product type e : enzyme; diacylglycerol kinase 4717132 dgkA 7139069 dgkA Escherichia coli ED1a diacylglycerol kinase YP_002400539.1 4716764 D 585397 CDS YP_002400540.1 218692328 7143102 4717242..4717850 1 NC_011745.1 Represses a number of genes involved in the response to DNA damage; LexA repressor 4717850 lexA 7143102 lexA Escherichia coli ED1a LexA repressor YP_002400540.1 4717242 D 585397 CDS YP_002400541.1 218692329 7141883 4717869..4719248 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87165788; Product type cp : cell process; DNA-damage-inducible SOS response protein 4719248 dinF 7141883 dinF Escherichia coli ED1a DNA-damage-inducible SOS response protein YP_002400541.1 4717869 D 585397 CDS YP_002400542.1 218692330 7140489 4719364..4719573 1 NC_011745.1 unknown function; highly abundant protein in vivo; overexpressed under high NaCl concentrations; part of the sigma S regulon; non-essential; putative stress-response protein 4719573 yjbJ 7140489 yjbJ Escherichia coli ED1a putative stress-response protein YP_002400542.1 4719364 D 585397 CDS YP_002400543.1 218692331 7142922 complement(4719615..4720130) 1 NC_011745.1 Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes znuACB; zinc uptake transcriptional repressor 4720130 zur 7142922 zur Escherichia coli ED1a zinc uptake transcriptional repressor YP_002400543.1 4719615 R 585397 CDS YP_002400544.1 218692332 7143199 4720286..4721281 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 22095566; Product type e : enzyme; tRNA-dihydrouridine synthase A 4721281 yjbN 7143199 yjbN Escherichia coli ED1a tRNA-dihydrouridine synthase A YP_002400544.1 4720286 D 585397 CDS YP_002400545.1 218692333 7142923 4721205..4721657 1 NC_011745.1 coordinately regulated along with pspA; PspF-dependent induction in response to secretin overexpression in Yersinia; phage shock protein G 4721657 pspG 7142923 pspG Escherichia coli ED1a phage shock protein G YP_002400545.1 4721205 D 585397 CDS YP_002400546.1 218692334 7142924 complement(4721822..4722805) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94089392, 7602590; Product type e : enzyme; quinone oxidoreductase, NADPH-dependent 4722805 qor 7142924 qor Escherichia coli ED1a quinone oxidoreductase, NADPH-dependent YP_002400546.1 4721822 R 585397 CDS YP_002400547.1 218692335 7141241 4722888..4724303 1 NC_011745.1 unwinds double stranded DNA; replicative DNA helicase 4724303 dnaB 7141241 dnaB Escherichia coli ED1a replicative DNA helicase YP_002400547.1 4722888 D 585397 CDS YP_002400548.1 218692336 7140503 4724356..4725435 1 NC_011745.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 4725435 alr 7140503 alr Escherichia coli ED1a alanine racemase YP_002400548.1 4724356 D 585397 CDS YP_002400549.1 218692337 7143695 4725688..4726881 1 NC_011745.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 4726881 tyrB 7143695 tyrB Escherichia coli ED1a aromatic amino acid aminotransferase YP_002400549.1 4725688 D 585397 CDS YP_002400550.1 218692338 7143865 4729840..4730994 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10739245, 6376124; Product type e : enzyme; dihydrolipoamide succinyltransferase (E2 component) 4730994 sucB 7143865 sucB Escherichia coli ED1a dihydrolipoamide succinyltransferase (E2 component) YP_002400550.1 4729840 D 585397 CDS YP_002400551.1 218692339 7143867 4731182..4732423 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative dihydrolipoyl dehydrogenase, E3 component (lpd-like) 4732423 7143867 ECED1_4772 Escherichia coli ED1a putative dihydrolipoyl dehydrogenase, E3 component (lpd-like) YP_002400551.1 4731182 D 585397 CDS YP_002400552.1 218692340 7143573 4732445..4733614 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type e : enzyme; Succinyl-CoA synthetase subunit beta (SCS-beta) 4733614 sucC 7143573 sucC Escherichia coli ED1a Succinyl-CoA synthetase subunit beta (SCS-beta) YP_002400552.1 4732445 D 585397 CDS YP_002400553.1 218692341 7143869 4733627..4734499 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type e : enzyme; Succinyl-CoA synthetase subunit alpha (SCS-alpha) 4734499 sucD 7143869 sucD Escherichia coli ED1a Succinyl-CoA synthetase subunit alpha (SCS-alpha) YP_002400553.1 4733627 D 585397 CDS YP_002400554.1 218692342 7143871 4734705..4736210 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 4736210 7143871 ECED1_4775 Escherichia coli ED1a putative transporter YP_002400554.1 4734705 D 585397 CDS YP_002400555.1 218692343 7143576 complement(4737283..4738641) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 3671068; Product type r : regulator; C4-dicarboxylate transport transcriptional regulatory protein 4738641 dctD 7143576 dctD Escherichia coli ED1a C4-dicarboxylate transport transcriptional regulatory protein YP_002400555.1 4737283 R 585397 CDS YP_002400556.1 218692344 7143073 complement(4738634..4740454) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2134335; Product type prc : putative receptor; putative C4-dicarboxylate transport sensor protein (dctB-like) 4740454 7143073 ECED1_4779 Escherichia coli ED1a putative C4-dicarboxylate transport sensor protein (dctB-like) YP_002400556.1 4738634 R 585397 CDS YP_002400557.1 218692345 7143577 4740731..4741444 1 NC_011745.1 Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity; acid phosphatase/phosphotransferase 4741444 aphA 7143577 aphA Escherichia coli ED1a acid phosphatase/phosphotransferase YP_002400557.1 4740731 D 585397 CDS YP_002400558.1 218692346 7142590 4741555..4741971 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11972052; hypothetical protein 4741971 yjbQ 7142590 yjbQ Escherichia coli ED1a hypothetical protein YP_002400558.1 4741555 D 585397 CDS YP_002400559.1 218692347 7142925 4741975..4742331 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4742331 yjbR 7142925 yjbR Escherichia coli ED1a hypothetical protein YP_002400559.1 4741975 D 585397 CDS YP_002400560.1 218692348 7142926 complement(4742366..4745188) 1 NC_011745.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 4745188 uvrA 7142926 uvrA Escherichia coli ED1a excinuclease ABC subunit A YP_002400560.1 4742366 R 585397 CDS YP_002400561.1 218692349 7139150 4745442..4745978 1 NC_011745.1 binds to single stranded DNA and PriA helcase facilitate replication restart; single-stranded DNA-binding protein 4745978 ssb 7139150 ssb Escherichia coli ED1a single-stranded DNA-binding protein YP_002400561.1 4745442 D 585397 CDS YP_002400562.1 218692350 7143847 complement(4746077..4746358) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4746358 yjcB 7143847 yjcB Escherichia coli ED1a hypothetical protein YP_002400562.1 4746077 R 585397 CDS YP_002400563.1 218692351 7142927 4746787..4748373 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative signal transduction protein 4748373 yjcC 7142927 yjcC Escherichia coli ED1a putative signal transduction protein YP_002400563.1 4746787 D 585397 CDS YP_002400564.1 218692352 7142928 complement(4748376..4748699) 1 NC_011745.1 regulates genes involved in response to oxidative stress; DNA-binding transcriptional regulator SoxS 4748699 soxS 7142928 soxS Escherichia coli ED1a DNA-binding transcriptional regulator SoxS YP_002400564.1 4748376 R 585397 CDS YP_002400565.1 218692353 7143822 4748785..4749249 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91210176, 91360349, 94139656, 9564045, 10207625, 12670967, 1653416, 1708380, 7673113, 8065907, 8306957, 8631739, 8969171, 9019397, 9092651, 9204707; Product type r : regulator; DNA-binding transcriptional dual regulator, Fe-S center for redox-sensing 4749249 soxR 7143822 soxR Escherichia coli ED1a DNA-binding transcriptional dual regulator, Fe-S center for redox-sensing YP_002400565.1 4748785 D 585397 CDS YP_002400566.1 218692354 7141354 4749796..4751145 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative permease 4751145 yjcD 7141354 yjcD Escherichia coli ED1a putative permease YP_002400566.1 4749796 D 585397 CDS YP_002400567.1 218692355 7142929 4751296..4752945 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 21557160, 11479290; Product type pt : putative transporter; putative cation/proton antiporter 4752945 yjcE 7142929 yjcE Escherichia coli ED1a putative cation/proton antiporter YP_002400567.1 4751296 D 585397 CDS YP_002400568.1 218692356 7142930 complement(4752981..4753865) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative LuxR family transcription regulator 4753865 7142930 ECED1_4792 Escherichia coli ED1a putative LuxR family transcription regulator YP_002400568.1 4752981 R 585397 CDS YP_002400569.1 218692357 7143578 4753969..4754379 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4754379 7143578 ECED1_4793 Escherichia coli ED1a hypothetical protein YP_002400569.1 4753969 D 585397 CDS YP_002400570.1 218692358 7143579 4754372..4755061 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4755061 7143579 ECED1_4794 Escherichia coli ED1a hypothetical protein YP_002400570.1 4754372 D 585397 CDS YP_002400571.1 218692359 7143580 complement(4755100..4756749) 1 NC_011745.1 member of the sodium:solute symporter family; cotranscribed with the acs gene which encodes acetyl coenzyme A synthase; mutations affect acetate uptake; acetate permease 4756749 actP 7143580 actP Escherichia coli ED1a acetate permease YP_002400571.1 4755100 R 585397 CDS YP_002400572.1 218692360 7143656 complement(4756746..4757060) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14563880; Product type pm : putative membrane component; hypothetical protein 4757060 yjcH 7143656 yjcH Escherichia coli ED1a hypothetical protein YP_002400572.1 4756746 R 585397 CDS YP_002400573.1 218692361 7142931 complement(4757273..4759231) 1 NC_011745.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA; acetyl-CoA synthetase 4759231 acs 7142931 acs Escherichia coli ED1a acetyl-CoA synthetase YP_002400573.1 4757273 R 585397 CDS YP_002400574.1 218692362 7143655 4759623..4761059 1 NC_011745.1 catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552; cytochrome c552 4761059 nrfA 7143655 nrfA Escherichia coli ED1a cytochrome c552 YP_002400574.1 4759623 D 585397 CDS YP_002400575.1 218692363 7139928 4761104..4761670 1 NC_011745.1 part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia; cytochrome c nitrite reductase pentaheme subunit 4761670 nrfB 7139928 nrfB Escherichia coli ED1a cytochrome c nitrite reductase pentaheme subunit YP_002400575.1 4761104 D 585397 CDS YP_002400576.1 218692364 7139929 4761667..4762338 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94335626, 8057835; Product type c : carrier; formate-dependent nitrite reductase, 4Fe4S subunit 4762338 nrfC 7139929 nrfC Escherichia coli ED1a formate-dependent nitrite reductase, 4Fe4S subunit YP_002400576.1 4761667 D 585397 CDS YP_002400577.1 218692365 7139930 4762335..4763291 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91058381, 94335626, 8057835; Product type e : enzyme; formate-dependent nitrite reductase, membrane subunit 4763291 nrfD 7139930 nrfD Escherichia coli ED1a formate-dependent nitrite reductase, membrane subunit YP_002400577.1 4762335 D 585397 CDS YP_002400578.1 218692366 7139931 4763371..4765029 1 NC_011745.1 with NrfF and NrfG catalyzes the insertion of heme into cytochrome c552; heme lyase subunit NrfE 4765029 nrfE 7139931 nrfE Escherichia coli ED1a heme lyase subunit NrfE YP_002400578.1 4763371 D 585397 CDS YP_002400579.1 218692367 7139932 4765022..4765405 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91058381, 94335626, 9593308, 8057835, 8842153; Product type f : factor; formate-dependent nitrite reductase complex subunit NrfF 4765405 nrfF 7139932 nrfF Escherichia coli ED1a formate-dependent nitrite reductase complex subunit NrfF YP_002400579.1 4765022 D 585397 CDS YP_002400580.1 218692368 7139933 4765402..4765998 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91058381, 94335626, 9593308, 8057835, 8842153; Product type f : factor; formate-dependent nitrite reductase complex subunit NrfG 4765998 nrfG 7139933 nrfG Escherichia coli ED1a formate-dependent nitrite reductase complex subunit NrfG YP_002400580.1 4765402 D 585397 CDS YP_002400581.1 218692369 7139934 4766341..4767654 1 NC_011745.1 carrier protein part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system; glutamate/aspartate:proton symporter 4767654 gltP 7139934 gltP Escherichia coli ED1a glutamate/aspartate:proton symporter YP_002400581.1 4766341 D 585397 CDS YP_002400582.1 218692370 7142985 complement(4768369..4769058) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4769058 yjcO 7142985 yjcO Escherichia coli ED1a hypothetical protein YP_002400582.1 4768369 R 585397 CDS YP_002400583.1 218692371 7142932 complement(4769169..4769873) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATP-binding protein YddO 4769873 7142932 ECED1_4807 Escherichia coli ED1a putative ABC transporter ATP-binding protein YddO YP_002400583.1 4769169 R 585397 CDS YP_002400584.1 218692372 7143581 complement(4769860..4770756) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative dipeptide/oligopeptide/nickel transport system, ATPase 4770756 7143581 ECED1_4808 Escherichia coli ED1a putative dipeptide/oligopeptide/nickel transport system, ATPase YP_002400584.1 4769860 R 585397 CDS YP_002400585.1 218692373 7143582 complement(4770689..4771522) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative dipeptide/nickel transporter, Inner membrane permease subunit (yddQ) 4771522 7143582 ECED1_4809 Escherichia coli ED1a putative dipeptide/nickel transporter, Inner membrane permease subunit (yddQ) YP_002400585.1 4770689 R 585397 CDS YP_002400586.1 218692374 7143583 complement(4771522..4772664) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative dipeptide/nickel transporter, Inner membrane permease subunit (yddR) 4772664 7143583 ECED1_4810 Escherichia coli ED1a putative dipeptide/nickel transporter, Inner membrane permease subunit (yddR) YP_002400586.1 4771522 R 585397 CDS YP_002400587.1 218692375 7143584 complement(4772671..4774239) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC-type dipeptide transport system, periplasmic component 4774239 7143584 ECED1_4811 Escherichia coli ED1a putative ABC-type dipeptide transport system, periplasmic component YP_002400587.1 4772671 R 585397 CDS YP_002400588.1 218692376 7143585 complement(4774614..4776761) 1 NC_011745.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; formate dehydrogenase-H, selenopolypeptide subunit 4776761 fdhF 7143585 fdhF Escherichia coli ED1a formate dehydrogenase-H, selenopolypeptide subunit YP_002400588.1 4774614 R 585397 CDS YP_002400589.1 218692377 7144138 complement(4776959..4778425) 1 NC_011745.1 part of a multidrug efflux system involved in resistance to acriflavin, puromycin, erytjhromycin and tetraphenylarsonium chloride; member of the outer membrane factor (OMF) family; putative outer membrane efflux protein MdtP 4778425 yjcP 7144138 yjcP Escherichia coli ED1a putative outer membrane efflux protein MdtP YP_002400589.1 4776959 R 585397 CDS YP_002400590.1 218692378 7142933 complement(4778422..4780473) 1 NC_011745.1 possibly part of a tripartite efflux system composed of MdtN, MdtO and MdtP which could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug efflux system protein MdtO 4780473 yjcQ 7142933 yjcQ Escherichia coli ED1a multidrug efflux system protein MdtO YP_002400590.1 4778422 R 585397 CDS YP_002400591.1 218692379 7142934 complement(4780473..4781504) 1 NC_011745.1 with MdtO and MdtP is involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug resistance protein MdtN 4781504 yjcR 7142934 yjcR Escherichia coli ED1a multidrug resistance protein MdtN YP_002400591.1 4780473 R 585397 CDS YP_002400592.1 218692380 7142935 complement(4782044..4784005) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1587481; Product type pe : putative enzyme; putative alkyl sulfatase 4784005 yjcS 7142935 yjcS Escherichia coli ED1a putative alkyl sulfatase YP_002400592.1 4782044 R 585397 CDS YP_002400593.1 218692381 7142936 complement(4784266..4785195) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20026827, 9401019; Product type e : enzyme; D-allose kinase 4785195 alsK 7142936 alsK Escherichia coli ED1a D-allose kinase YP_002400593.1 4784266 R 585397 CDS YP_002400594.1 218692382 7143700 complement(4785179..4785874) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20026827, 9401019; Product type e : enzyme; allulose-6-phosphate 3-epimerase 4785874 alsE 7143700 alsE Escherichia coli ED1a allulose-6-phosphate 3-epimerase YP_002400594.1 4785179 R 585397 CDS YP_002400595.1 218692383 7143699 complement(4785885..4786865) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20026827, 9401019; Product type t : transporter; D-allose transporter subunit 4786865 alsC 7143699 alsC Escherichia coli ED1a D-allose transporter subunit YP_002400595.1 4785885 R 585397 CDS YP_002400596.1 218692384 7143698 complement(4786844..4788376) 1 NC_011745.1 with AlsBC acts to import allose into the cell; AlsA contain 2 ATP-binding domains; D-allose transporter ATP-binding protein 4788376 alsA 7143698 alsA Escherichia coli ED1a D-allose transporter ATP-binding protein YP_002400596.1 4786844 R 585397 CDS YP_002400597.1 218692385 7143696 complement(4788504..4789439) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20026827, 9401019, 10064713, 8576032; Product type t : transporter; D-allose transporter subunit 4789439 alsB 7143696 alsB Escherichia coli ED1a D-allose transporter subunit YP_002400597.1 4788504 R 585397 CDS YP_002400598.1 218692386 7143697 complement(4789498..4790388) 1 NC_011745.1 involved in rpiB and als operon repression; DNA-binding transcriptional repressor RpiR 4790388 rpiR 7143697 rpiR Escherichia coli ED1a DNA-binding transcriptional repressor RpiR YP_002400598.1 4789498 R 585397 CDS YP_002400599.1 218692387 7141451 4790747..4791196 1 NC_011745.1 catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity; ribose-5-phosphate isomerase B 4791196 rpiB 7141451 rpiB Escherichia coli ED1a ribose-5-phosphate isomerase B YP_002400599.1 4790747 D 585397 CDS YP_002400600.1 218692388 7141450 4791265..4791594 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4791594 yjdP 7141450 yjdP Escherichia coli ED1a hypothetical protein YP_002400600.1 4791265 D 585397 CDS YP_002400601.1 218692389 7142946 complement(4791622..4792380) 1 NC_011745.1 required for the use of phosphonates and phosphite as phosphorus sources; carbon-phosphorus lyase complex accessory protein 4792380 phnP 7142946 phnP Escherichia coli ED1a carbon-phosphorus lyase complex accessory protein YP_002400601.1 4791622 R 585397 CDS YP_002400602.1 218692390 7144101 complement(4792382..4792816) 1 NC_011745.1 PhnO in Salmonella enterica catalyzes the acetylation of a range of aminoalkylphosphonic acids; part of the biochemical pathway that enables the cell to use phosphonates as a phosphorus source; Escherichia coli uses a different mechanism of phosphonate catabolism where PhnO is not essential and seems to play a regulatory role; aminoalkylphosphonic acid N-acetyltransferase 4792816 phnO 7144101 phnO Escherichia coli ED1a aminoalkylphosphonic acid N-acetyltransferase YP_002400602.1 4792382 R 585397 CDS YP_002400603.1 218692391 7144100 complement(4792803..4793360) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12700258, 91100346, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; ribose 1,5-bisphosphokinase 4793360 phnN 7144100 phnN Escherichia coli ED1a ribose 1,5-bisphosphokinase YP_002400603.1 4792803 R 585397 CDS YP_002400604.1 218692392 7144099 complement(4793360..4794496) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91100346, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit 4794496 phnM 7144099 phnM Escherichia coli ED1a carbon-phosphorus lyase complex subunit YP_002400604.1 4793360 R 585397 CDS YP_002400605.1 218692393 7144098 complement(4794493..4795173) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit 4795173 phnL 7144098 phnL Escherichia coli ED1a carbon-phosphorus lyase complex subunit YP_002400605.1 4794493 R 585397 CDS YP_002400606.1 218692394 7144097 complement(4795284..4796042) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; phosphonate C-P lyase system protein PhnK 4796042 phnK 7144097 phnK Escherichia coli ED1a phosphonate C-P lyase system protein PhnK YP_002400606.1 4795284 R 585397 CDS YP_002400607.1 218692395 7144096 complement(4796039..4796884) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit 4796884 phnJ 7144096 phnJ Escherichia coli ED1a carbon-phosphorus lyase complex subunit YP_002400607.1 4796039 R 585397 CDS YP_002400608.1 218692396 7144095 complement(4796877..4797941) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit 4797941 phnI 7144095 phnI Escherichia coli ED1a carbon-phosphorus lyase complex subunit YP_002400608.1 4796877 R 585397 CDS YP_002400609.1 218692397 7144094 complement(4797941..4798525) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit 4798525 phnH 7144094 phnH Escherichia coli ED1a carbon-phosphorus lyase complex subunit YP_002400609.1 4797941 R 585397 CDS YP_002400610.1 218692398 7144093 complement(4798522..4798974) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit 4798974 phnG 7144093 phnG Escherichia coli ED1a carbon-phosphorus lyase complex subunit YP_002400610.1 4798522 R 585397 CDS YP_002400611.1 218692399 7144092 complement(4798975..4799700) 1 NC_011745.1 may be involved in phosphonate uptake and biodegradation; phosphonate metabolism transcriptional regulator PhnF 4799700 phnF 7144092 phnF Escherichia coli ED1a phosphonate metabolism transcriptional regulator PhnF YP_002400611.1 4798975 R 585397 CDS YP_002400612.1 218692400 7144091 complement(4799721..4800563) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; phosphonates transport system permease 4800563 phnE 7144091 phnE Escherichia coli ED1a phosphonates transport system permease YP_002400612.1 4799721 R 585397 CDS YP_002400613.1 218692401 7144090 complement(4800606..4801622) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type t : transporter; phosphonate/organophosphate ester ABC transporter periplasmic binding protein 4801622 phnD 7144090 phnD Escherichia coli ED1a phosphonate/organophosphate ester ABC transporter periplasmic binding protein YP_002400613.1 4800606 R 585397 CDS YP_002400614.1 218692402 7144089 complement(4801647..4802435) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type t : transporter; phosphonate/organophosphate ester transporter subunit 4802435 phnC 7144089 phnC Escherichia coli ED1a phosphonate/organophosphate ester transporter subunit YP_002400614.1 4801647 R 585397 CDS YP_002400615.1 218692403 7144088 complement(4802568..4803011) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 93328121, 9650256, 2155230; hypothetical protein 4803011 phnB 7144088 phnB Escherichia coli ED1a hypothetical protein YP_002400615.1 4802568 R 585397 CDS YP_002400616.1 218692404 7144087 complement(4803171..4803653) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9650256, 2155230; Product type pt : putative transporter; putative alkylphosphonate uptake protein in phosphonate metabolism 4803653 7144087 ECED1_4842 Escherichia coli ED1a putative alkylphosphonate uptake protein in phosphonate metabolism YP_002400616.1 4803171 R 585397 CDS YP_002400617.1 218692405 7143586 4803908..4806136 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4806136 yjdA 7143586 yjdA Escherichia coli ED1a hypothetical protein YP_002400617.1 4803908 D 585397 CDS YP_002400618.1 218692406 7142938 4806133..4807011 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4807011 yjcZ 7142938 yjcZ Escherichia coli ED1a hypothetical protein YP_002400618.1 4806133 D 585397 CDS YP_002400619.1 218692407 7142937 4807275..4808777 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10049386, 12525168, 92165733, 93132799, 9871325, 99376621, 8421314; Product type t : transporter; proline/glycine betaine transporter 4808777 proP 7142937 proP Escherichia coli ED1a proline/glycine betaine transporter YP_002400619.1 4807275 D 585397 CDS YP_002400620.1 218692408 7139130 complement(4808954..4810045) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94110256, 8282725; Product type r : regulator; sensor protein BasS/PmrB 4810045 basS 7139130 basS Escherichia coli ED1a sensor protein BasS/PmrB YP_002400620.1 4808954 R 585397 CDS YP_002400621.1 218692409 7140431 complement(4810055..4810723) 1 NC_011745.1 response regulator in two-component regulatory system with BasS; DNA-binding transcriptional regulator BasR 4810723 basR 7140431 basR Escherichia coli ED1a DNA-binding transcriptional regulator BasR YP_002400621.1 4810055 R 585397 CDS YP_002400622.1 218692410 7140430 complement(4810720..4812363) 1 NC_011745.1 with ZipA and an unidentified 24 kDa protein forms a complex involved in cell division; putative cell division protein 4812363 eptA 7140430 eptA Escherichia coli ED1a putative cell division protein YP_002400622.1 4810720 R 585397 CDS YP_002400623.1 218692411 7139807 complement(4812467..4813804) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12867448; Product type t : transporter; arginine:agmatin antiporter 4813804 adiC 7139807 adiC Escherichia coli ED1a arginine:agmatin antiporter YP_002400623.1 4812467 R 585397 CDS YP_002400624.1 218692412 7143663 complement(4813941..4814702) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : c; Product type r : regulator; DNA-binding transcriptional activator 4814702 adiY 7143663 adiY Escherichia coli ED1a DNA-binding transcriptional activator YP_002400624.1 4813941 R 585397 CDS YP_002400625.1 218692413 7143664 complement(4815038..4817308) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93186686, 2830169, 4204273, 8383109; Product type e : enzyme; biodegradative arginine decarboxylase 4817308 adiA 7143664 adiA Escherichia coli ED1a biodegradative arginine decarboxylase YP_002400625.1 4815038 R 585397 CDS YP_002400626.1 218692414 7143662 complement(4817504..4818412) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90060832, 9108148, 1445207, 2684786, 2830169; Product type r : regulator; DNA-binding transcriptional regulator MelR 4818412 melR 7143662 melR Escherichia coli ED1a DNA-binding transcriptional regulator MelR YP_002400626.1 4817504 R 585397 CDS YP_002400627.1 218692415 7142240 4818695..4820050 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87174747, 88162811, 90248411, 2831880, 3031590, 6329200; Product type e : enzyme; alpha-galactosidase, NAD(P)-binding 4820050 melA 7142240 melA Escherichia coli ED1a alpha-galactosidase, NAD(P)-binding YP_002400627.1 4818695 D 585397 CDS YP_002400628.1 218692416 7142239 complement(4820047..4820697) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4820697 yjdF 7142239 yjdF Escherichia coli ED1a hypothetical protein YP_002400628.1 4820047 R 585397 CDS YP_002400629.1 218692417 7142940 complement(4820820..4822466) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86142617, 88193096, 89255123, 2656658; Product type e : enzyme; anaerobic class I fumarate hydratase 4822466 fumB 7142940 fumB Escherichia coli ED1a anaerobic class I fumarate hydratase YP_002400629.1 4820820 R 585397 CDS YP_002400630.1 218692418 7143132 complement(4822544..4823884) 1 NC_011745.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters; anaerobic C4-dicarboxylate transporter 4823884 dcuB 7143132 dcuB Escherichia coli ED1a anaerobic C4-dicarboxylate transporter YP_002400630.1 4822544 R 585397 CDS YP_002400631.1 218692419 7143075 complement(4824455..4825174) 1 NC_011745.1 response regulator in two-component regulatory system with DcuS; phosphorylated DcuR activates transcription of genes involved in anaerobic fumarate respiration; DNA-binding transcriptional activator DcuR 4825174 dcuR 7143075 dcuR Escherichia coli ED1a DNA-binding transcriptional activator DcuR YP_002400631.1 4824455 R 585397 CDS YP_002400632.1 218692420 7143077 complement(4825171..4826802) 1 NC_011745.1 C4-dicarboxylate-sensing histidine kinase; part of two-component regulatory system with DcuR; regulates anaerobic fumarate respiration; sensory histidine kinase DcuS 4826802 dcuS 7143077 dcuS Escherichia coli ED1a sensory histidine kinase DcuS YP_002400632.1 4825171 R 585397 CDS YP_002400633.1 218692421 7143078 4826983..4827213 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4827213 yjdI 7143078 yjdI Escherichia coli ED1a hypothetical protein YP_002400633.1 4826983 D 585397 CDS YP_002400634.1 218692422 7142941 4827225..4827497 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acyl-CoA N-acyltransferase domain-containing acyltransferase 4827497 yjdJ 7142941 yjdJ Escherichia coli ED1a putative acyl-CoA N-acyltransferase domain-containing acyltransferase YP_002400634.1 4827225 D 585397 CDS YP_002400635.1 218692423 7142942 4827725..4828021 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4828021 yjdK 7142942 yjdK Escherichia coli ED1a hypothetical protein YP_002400635.1 4827725 D 585397 CDS YP_002400636.1 218692424 7142943 4828049..4828222 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4828222 yjdO 7142943 yjdO Escherichia coli ED1a hypothetical protein YP_002400636.1 4828049 D 585397 CDS YP_002400637.1 218692425 7142945 complement(4828341..4829858) 1 NC_011745.1 class II; inducible; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; induced by high temperature, anaerobiosis, and low pH; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 4829858 lysU 7142945 lysU Escherichia coli ED1a lysyl-tRNA synthetase YP_002400637.1 4828341 R 585397 CDS YP_002400638.1 218692426 7141936 complement(4830095..4831552) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 4831552 yjdL 7141936 yjdL Escherichia coli ED1a putative transporter YP_002400638.1 4830095 R 585397 CDS YP_002400639.1 218692427 7142944 complement(4831611..4833758) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92105022, 92210511, 1370290, 1556085, 4204273; Product type e : enzyme; lysine decarboxylase 1 4833758 cadA 7142944 cadA Escherichia coli ED1a lysine decarboxylase 1 YP_002400639.1 4831611 R 585397 CDS YP_002400640.1 218692428 7140477 complement(4833838..4835172) 1 NC_011745.1 antiporter protein responsible for lysine import and cadaverine export; member of the lysine-dependent acid resistance system 4 (AR4); inner membrane protein; lysine/cadaverine antiporter 4835172 cadB 7140477 cadB Escherichia coli ED1a lysine/cadaverine antiporter YP_002400640.1 4833838 R 585397 CDS YP_002400641.1 218692429 7140478 complement(4835538..4837076) 1 NC_011745.1 regulates the cadBA operon; DNA-binding transcriptional activator CadC 4837076 cadC 7140478 cadC Escherichia coli ED1a DNA-binding transcriptional activator CadC YP_002400641.1 4835538 R 585397 CDS YP_002400642.1 218692430 7140479 4837363..4837581 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4837581 7140479 ECED1_4870 Escherichia coli ED1a hypothetical protein YP_002400642.1 4837363 D 585397 CDS YP_002400643.1 218692431 7143588 complement(4838491..4838733) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4838733 7143588 ECED1_4872 Escherichia coli ED1a hypothetical protein YP_002400643.1 4838491 R 585397 CDS YP_002400644.1 218692432 7143589 complement(4838700..4839188) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4839188 yeeW 7143589 yeeW Escherichia coli ED1a hypothetical protein YP_002400644.1 4838700 R 585397 CDS YP_002400645.1 218692433 7139406 complement(4839185..4839559) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594833; Product type h : extrachromosomal origin; toxin of the YeeV-YeeU toxin-antitoxin system; CP4-44 prophage 4839559 yeeV 7139406 yeeV Escherichia coli ED1a toxin of the YeeV-YeeU toxin-antitoxin system; CP4-44 prophage YP_002400645.1 4839185 R 585397 CDS YP_002400646.1 218692434 7139402 complement(4839649..4840017) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594833; Product type h : extrachromosomal origin; CP4-44 prophage YeeV-YeeU toxin-antitoxin system toxin 4840017 yeeU 7139402 yeeU Escherichia coli ED1a CP4-44 prophage YeeV-YeeU toxin-antitoxin system toxin YP_002400646.1 4839649 R 585397 CDS YP_002400647.1 218692435 7139397 complement(4840067..4840180) 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 4840180 7139397 ECED1_4876 Escherichia coli ED1a hypothetical protein YP_002400647.1 4840067 R 585397 CDS YP_002400648.1 218692436 7143590 complement(4840180..4840401) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 4840401 yeeT 7143590 yeeT Escherichia coli ED1a hypothetical protein YP_002400648.1 4840180 R 585397 CDS YP_002400649.1 218692437 7139392 complement(4840464..4840910) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11053371; Product type pf : putative factor; putative DNA repair protein; CP4-44 prophage 4840910 yeeS 7139392 yeeS Escherichia coli ED1a putative DNA repair protein; CP4-44 prophage YP_002400649.1 4840464 R 585397 CDS YP_002400650.1 218692438 7139387 complement(4840956..4841294) 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 4841294 7139387 ECED1_4879 Escherichia coli ED1a hypothetical protein YP_002400650.1 4840956 R 585397 CDS YP_002400651.1 218692439 7143592 complement(4841495..4842313) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4842313 7143592 ECED1_4881 Escherichia coli ED1a hypothetical protein YP_002400651.1 4841495 R 585397 CDS YP_002400652.1 218692440 7143593 complement(4842413..4842646) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4842646 7143593 ECED1_4882 Escherichia coli ED1a hypothetical protein YP_002400652.1 4842413 R 585397 CDS YP_002400653.1 218692441 7143594 complement(4842725..4843180) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4843180 7143594 ECED1_4883 Escherichia coli ED1a hypothetical protein YP_002400653.1 4842725 R 585397 CDS YP_002400654.1 218692442 7143595 complement(4843256..4845778) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4845778 7143595 ECED1_4884 Escherichia coli ED1a hypothetical protein YP_002400654.1 4843256 R 585397 CDS YP_002400655.1 218692443 7143597 complement(4846976..4847659) 1 NC_011745.1 Evidence 7 : Gene remnant; hypothetical protein 4847659 7143597 ECED1_4886 Escherichia coli ED1a hypothetical protein YP_002400655.1 4846976 R 585397 CDS YP_002400656.1 218692444 7143598 4847548..4847823 1 NC_011745.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF3 (fragment), ISEc8, IS66 family 4847823 7143598 ECED1_4887 Escherichia coli ED1a transposase ORF3 (fragment), ISEc8, IS66 family YP_002400656.1 4847548 D 585397 CDS YP_002400657.1 218692445 7143599 4848031..4848192 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4848192 7143599 ECED1_4888 Escherichia coli ED1a hypothetical protein YP_002400657.1 4848031 D 585397 CDS YP_002400658.1 218692446 7143600 4848285..4849517 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative reverse transcriptase 4849517 7143600 ECED1_4889 Escherichia coli ED1a putative reverse transcriptase YP_002400658.1 4848285 D 585397 CDS YP_002400659.1 218692447 7143602 4850007..4850432 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative transposase OrfA from plasmid origin 4850432 7143602 ECED1_4891 Escherichia coli ED1a putative transposase OrfA from plasmid origin YP_002400659.1 4850007 D 585397 CDS YP_002400660.1 218692448 7143603 4850429..4850779 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative transposase ORF2, IS66 family 4850779 7143603 ECED1_4892 Escherichia coli ED1a putative transposase ORF2, IS66 family YP_002400660.1 4850429 D 585397 CDS YP_002400661.1 218692449 7143604 4850810..4852453 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4852453 7143604 ECED1_4893 Escherichia coli ED1a hypothetical protein YP_002400661.1 4850810 D 585397 CDS YP_002400662.1 218692450 7143605 complement(4852600..4852824) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4852824 7143605 ECED1_4894 Escherichia coli ED1a hypothetical protein YP_002400662.1 4852600 R 585397 CDS YP_002400663.1 218692451 7143606 complement(4853058..4855148) 1 NC_011745.1 IrgA-homologue adhesin (Iha); TonB-dependent; acts as a specific receptor of enterobactin; fur-regulated; urovirulence factor; bifunctional enterobactin receptor/adhesin protein 4855148 7143606 ECED1_4895 Escherichia coli ED1a bifunctional enterobactin receptor/adhesin protein YP_002400663.1 4853058 R 585397 CDS YP_002400664.1 218692452 7143610 4857556..4857720 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4857720 7143610 ECED1_4899 Escherichia coli ED1a hypothetical protein YP_002400664.1 4857556 D 585397 CDS YP_002400665.1 218692453 7143611 complement(4858519..4858677) 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 4858677 7143611 ECED1_4900 Escherichia coli ED1a hypothetical protein YP_002400665.1 4858519 R 585397 CDS YP_002400666.1 218692454 7143612 complement(4858683..4860962) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 4313071, 6456229, 7044820, 7042696, 6749806; Product type rc : receptor; Ferric aerobactin receptor 4860962 iutA 7143612 iutA Escherichia coli ED1a Ferric aerobactin receptor YP_002400666.1 4858683 R 585397 CDS YP_002400667.1 218692455 7142475 complement(4860884..4862221) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3275632, 10064136; Product type e : enzyme; L-lysine 6-monooxygenase 4862221 iucD 7142475 iucD Escherichia coli ED1a L-lysine 6-monooxygenase YP_002400667.1 4860884 R 585397 CDS YP_002400668.1 218692456 7142474 complement(4862218..4863960) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3087960; Product type e : enzyme; Aerobactin siderophore biosynthesis protein 4863960 iucC 7142474 iucC Escherichia coli ED1a Aerobactin siderophore biosynthesis protein YP_002400668.1 4862218 R 585397 CDS YP_002400669.1 218692457 7142473 complement(4863960..4864907) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3087960; Product type e : enzyme; aerobactin siderophore biosynthesis N(6)-hydroxylysine acetylase 4864907 iucB 7142473 iucB Escherichia coli ED1a aerobactin siderophore biosynthesis N(6)-hydroxylysine acetylase YP_002400669.1 4863960 R 585397 CDS YP_002400670.1 218692458 7142472 complement(4864908..4866698) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3087960; Product type e : enzyme; aerobactin siderophore biosynthesis protein 4866698 iucA 7142472 iucA Escherichia coli ED1a aerobactin siderophore biosynthesis protein YP_002400670.1 4864908 R 585397 CDS YP_002400671.1 218692459 7143796 complement(4867561..4867911) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative transposase ORF2, IS66 family 4867911 7143796 ECED1_4907 Escherichia coli ED1a putative transposase ORF2, IS66 family YP_002400671.1 4867561 R 585397 CDS YP_002400672.1 218692460 7143613 complement(4867908..4868333) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative transposase 4868333 7143613 ECED1_4908 Escherichia coli ED1a putative transposase YP_002400672.1 4867908 R 585397 CDS YP_002400673.1 218692461 7143614 4868361..4868564 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4868564 7143614 ECED1_4909 Escherichia coli ED1a hypothetical protein YP_002400673.1 4868361 D 585397 CDS YP_002400674.1 218692462 7143615 4868539..4868802 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4868802 7143615 ECED1_4910 Escherichia coli ED1a hypothetical protein YP_002400674.1 4868539 D 585397 CDS YP_002400675.1 218692463 7143616 4868995..4869912 1 NC_011745.1 catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid; N-acetylneuraminate lyase 4869912 7143616 ECED1_4911 Escherichia coli ED1a N-acetylneuraminate lyase YP_002400675.1 4868995 D 585397 CDS YP_002400676.1 218692464 7143617 4869946..4870821 1 NC_011745.1 catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein; N-acetylmannosamine kinase 4870821 nanK 7143617 nanK Escherichia coli ED1a N-acetylmannosamine kinase YP_002400676.1 4869946 D 585397 CDS YP_002400677.1 218692465 7140346 4870834..4872342 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; putative sialic acid transporter 4872342 7140346 ECED1_4913 Escherichia coli ED1a putative sialic acid transporter YP_002400677.1 4870834 D 585397 CDS YP_002400678.1 218692466 7143618 4872346..4873176 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4873176 7143618 ECED1_4914 Escherichia coli ED1a hypothetical protein YP_002400678.1 4872346 D 585397 CDS YP_002400679.1 218692467 7143619 4873192..4873932 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15743943; Product type pm : putative membrane component; putative N-acetylneuraminic acid outer membrane channel protein nanC 4873932 7143619 ECED1_4915 Escherichia coli ED1a putative N-acetylneuraminic acid outer membrane channel protein nanC YP_002400679.1 4873192 D 585397 CDS YP_002400680.1 218692468 7143620 4873936..4875054 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; N-acetylneuraminic acid mutarotase 4875054 7143620 ECED1_4916 Escherichia coli ED1a N-acetylneuraminic acid mutarotase YP_002400680.1 4873936 D 585397 CDS YP_002400681.1 218692469 7143621 4875104..4876039 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase 4876039 7143621 ECED1_4917 Escherichia coli ED1a putative hydrolase YP_002400681.1 4875104 D 585397 CDS YP_002400682.1 218692470 7143622 complement(4876075..4876809) 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type r : regulator; Transcriptional regulator 4876809 nanR 7143622 nanR Escherichia coli ED1a Transcriptional regulator YP_002400682.1 4876075 R 585397 CDS YP_002400683.1 218692471 7140348 4876906..4877895 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4877895 7140348 ECED1_4919 Escherichia coli ED1a hypothetical protein YP_002400683.1 4876906 D 585397 CDS YP_002400684.1 218692472 7143624 complement(4879739..4881001) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Prophage integrase 4881001 int 7143624 int Escherichia coli ED1a Prophage integrase YP_002400684.1 4879739 R 585397 CDS YP_002400685.1 218692473 7140604 complement(4881381..4881956) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1370290; Product type pr : putative regulator; putative transcriptional regulator 4881956 yjdC 7140604 yjdC Escherichia coli ED1a putative transcriptional regulator YP_002400685.1 4881381 R 585397 CDS YP_002400686.1 218692474 7142939 complement(4881993..4883690) 1 NC_011745.1 two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm; thiol:disulfide interchange protein 4883690 dipZ 7142939 dipZ Escherichia coli ED1a thiol:disulfide interchange protein YP_002400686.1 4881993 R 585397 CDS YP_002400687.1 218692475 7140492 complement(4883666..4884004) 1 NC_011745.1 copper binding protein required for copper tolerance; involved in resistance toward heavy metals; divalent-cation tolerance protein CutA 4884004 cutA 7140492 cutA Escherichia coli ED1a divalent-cation tolerance protein CutA YP_002400687.1 4883666 R 585397 CDS YP_002400688.1 218692476 7142089 complement(4884120..4885421) 1 NC_011745.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB; anaerobic C4-dicarboxylate transporter 4885421 dcuA 7142089 dcuA Escherichia coli ED1a anaerobic C4-dicarboxylate transporter YP_002400688.1 4884120 R 585397 CDS YP_002400689.1 218692477 7143074 complement(4885539..4886975) 1 NC_011745.1 catalyzes the formation of fumarate from aspartate; aspartate ammonia-lyase 4886975 aspA 7143074 aspA Escherichia coli ED1a aspartate ammonia-lyase YP_002400689.1 4885539 R 585397 CDS YP_002400690.1 218692478 7142649 4887312..4887788 1 NC_011745.1 F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein; FxsA protein 4887788 fxsA 7142649 fxsA Escherichia coli ED1a FxsA protein YP_002400690.1 4887312 D 585397 CDS YP_002400691.1 218692479 7143136 complement(4887804..4889060) 1 NC_011745.1 uncharacterized member of the APC superfamily of amino acid transporters; unknown function; inner membrane protein YjeH 4889060 yjeH 7143136 yjeH Escherichia coli ED1a inner membrane protein YjeH YP_002400691.1 4887804 R 585397 CDS YP_002400692.1 218692480 7142949 4889336..4889629 1 NC_011745.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 4889629 groES 7142949 groES Escherichia coli ED1a co-chaperonin GroES YP_002400692.1 4889336 D 585397 CDS YP_002400693.1 218692481 7143022 4889673..4891319 1 NC_011745.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL 4891319 groEL 7143022 groEL Escherichia coli ED1a chaperonin GroEL YP_002400693.1 4889673 D 585397 CDS YP_002400694.1 218692482 7143021 4891457..4891810 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4891810 yjeI 7143021 yjeI Escherichia coli ED1a hypothetical protein YP_002400694.1 4891457 D 585397 CDS YP_002400695.1 218692483 7142950 complement(4891860..4892729) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4892729 yjeJ 7142950 yjeJ Escherichia coli ED1a hypothetical protein YP_002400695.1 4891860 R 585397 CDS YP_002400696.1 218692484 7142951 complement(4892964..4893992) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2019591, 10629195; Product type pe : putative enzyme; putative lysine aminomutase 4893992 yjeK 7142951 yjeK Escherichia coli ED1a putative lysine aminomutase YP_002400696.1 4892964 R 585397 CDS YP_002400697.1 218692485 7142953 4894034..4894600 1 NC_011745.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 4894600 efp 7142953 efp Escherichia coli ED1a elongation factor P YP_002400697.1 4894034 D 585397 CDS YP_002400698.1 218692486 7139777 4894888..4895034 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98344100, 9677290; Product type lp : lipoprotein; entericidin B membrane lipoprotein 4895034 ecnB 7139777 ecnB Escherichia coli ED1a entericidin B membrane lipoprotein YP_002400698.1 4894888 D 585397 CDS YP_002400699.1 218692487 7139768 4895210..4895527 1 NC_011745.1 member of the SMR family of proton-dependent drug efflux transporters; quaternary ammonium compound efflux pump; confers resistance to cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations; quaternary ammonium compound-resistance protein SugE 4895527 sugE 7139768 sugE Escherichia coli ED1a quaternary ammonium compound-resistance protein SugE YP_002400699.1 4895210 D 585397 CDS YP_002400700.1 218692488 7141497 complement(4895524..4896057) 1 NC_011745.1 lipocalin; globomycin-sensitive outer membrane lipoprotein; outer membrane lipoprotein Blc 4896057 blc 7141497 blc Escherichia coli ED1a outer membrane lipoprotein Blc YP_002400700.1 4895524 R 585397 CDS YP_002400701.1 218692489 7140459 complement(4896146..4897279) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92212899, 97464439, 99421326, 10595535, 6795623, 7041115, 9819201; Product type e : enzyme; beta-lactamase 4897279 ampC 7140459 ampC Escherichia coli ED1a beta-lactamase YP_002400701.1 4896146 R 585397 CDS YP_002400702.1 218692490 7143706 complement(4897342..4897701) 1 NC_011745.1 in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane; fumarate reductase subunit D 4897701 frdD 7143706 frdD Escherichia coli ED1a fumarate reductase subunit D YP_002400702.1 4897342 R 585397 CDS YP_002400703.1 218692491 7142169 complement(4897712..4898107) 1 NC_011745.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase subunit C 4898107 frdC 7142169 frdC Escherichia coli ED1a fumarate reductase subunit C YP_002400703.1 4897712 R 585397 CDS YP_002400704.1 218692492 7142168 complement(4898118..4898852) 1 NC_011745.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase iron-sulfur subunit 4898852 frdB 7142168 frdB Escherichia coli ED1a fumarate reductase iron-sulfur subunit YP_002400704.1 4898118 R 585397 CDS YP_002400705.1 218692493 7142167 complement(4898845..4900653) 1 NC_011745.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase flavoprotein subunit 4900653 frdA 7142167 frdA Escherichia coli ED1a fumarate reductase flavoprotein subunit YP_002400705.1 4898845 R 585397 CDS YP_002400706.1 218692494 7142166 4900978..4901955 1 NC_011745.1 lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase 4901955 poxA 7142166 poxA Escherichia coli ED1a lysyl-tRNA synthetase YP_002400706.1 4900978 D 585397 CDS YP_002400707.1 218692495 7139093 4902132..4903628 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 4903628 yjeM 7139093 yjeM Escherichia coli ED1a putative transporter YP_002400707.1 4902132 D 585397 CDS YP_002400708.1 218692496 7138875 complement(4903827..4907150) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; hypothetical protein 4907150 yjeP 7138875 yjeP Escherichia coli ED1a hypothetical protein YP_002400708.1 4903827 R 585397 CDS YP_002400709.1 218692497 7139548 complement(4907172..4908140) 1 NC_011745.1 catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine; phosphatidylserine decarboxylase 4908140 psd 7139548 psd Escherichia coli ED1a phosphatidylserine decarboxylase YP_002400709.1 4907172 R 585397 CDS YP_002400710.1 218692498 7141188 complement(4908237..4909289) 1 NC_011745.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase 4909289 rsgA 7141188 rsgA Escherichia coli ED1a ribosome-associated GTPase YP_002400710.1 4908237 R 585397 CDS YP_002400711.1 218692499 7140113 4909384..4909929 1 NC_011745.1 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 4909929 orn 7140113 orn Escherichia coli ED1a oligoribonuclease YP_002400711.1 4909384 D 585397 CDS YP_002400712.1 218692500 7140599 complement(4910708..4911847) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative Fe-S electron transport protein 4911847 yjeS 7140599 yjeS Escherichia coli ED1a putative Fe-S electron transport protein YP_002400712.1 4910708 R 585397 CDS YP_002400713.1 218692501 7139549 4911825..4913393 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 4913393 yjeF 7139549 yjeF Escherichia coli ED1a hypothetical protein YP_002400713.1 4911825 D 585397 CDS YP_002400714.1 218692502 7142948 4913365..4913826 1 NC_011745.1 possibly involved in cell wall synthesis; putative ATPase 4913826 yjeE 7142948 yjeE Escherichia coli ED1a putative ATPase YP_002400714.1 4913365 D 585397 CDS YP_002400715.1 218692503 7142947 4913830..4915176 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21348478, 87242501, 1594459, 7511774; Product type e : enzyme; N-acetylmuramoyl-l-alanine amidase II 4915176 amiB 7142947 amiB Escherichia coli ED1a N-acetylmuramoyl-l-alanine amidase II YP_002400715.1 4913830 D 585397 CDS YP_002400716.1 218692504 7143703 4915186..4917033 1 NC_011745.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 4917033 mutL 7143703 mutL Escherichia coli ED1a DNA mismatch repair protein YP_002400716.1 4915186 D 585397 CDS YP_002400717.1 218692505 7139055 4917026..4917976 1 NC_011745.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 4917976 miaA 7139055 miaA Escherichia coli ED1a tRNA delta(2)-isopentenylpyrophosphate transferase YP_002400717.1 4917026 D 585397 CDS YP_002400718.1 218692506 7138979 4918062..4918370 1 NC_011745.1 Stimulates the elongation of poly(A) tails; RNA-binding protein Hfq 4918370 hfq 7138979 hfq Escherichia coli ED1a RNA-binding protein Hfq YP_002400718.1 4918062 D 585397 CDS YP_002400719.1 218692507 7139882 4918446..4919726 1 NC_011745.1 involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein; putative GTPase HflX 4919726 hflX 7139882 hflX Escherichia coli ED1a putative GTPase HflX YP_002400719.1 4918446 D 585397 CDS YP_002400720.1 218692508 7139881 4919812..4921071 1 NC_011745.1 with HflC inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflK 4921071 hflK 7139881 hflK Escherichia coli ED1a FtsH protease regulator HflK YP_002400720.1 4919812 D 585397 CDS YP_002400721.1 218692509 7139880 4921074..4922078 1 NC_011745.1 with HflK inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflC 4922078 hflC 7139880 hflC Escherichia coli ED1a FtsH protease regulator HflC YP_002400721.1 4921074 D 585397 CDS YP_002400722.1 218692510 7139878 4922160..4922357 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4922357 yjeT 7139878 yjeT Escherichia coli ED1a hypothetical protein YP_002400722.1 4922160 D 585397 CDS YP_002400723.1 218692511 7139550 4922461..4923759 1 NC_011745.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 4923759 purA 7139550 purA Escherichia coli ED1a adenylosuccinate synthetase YP_002400723.1 4922461 D 585397 CDS YP_002400724.1 218692512 7141213 4923964..4924389 1 NC_011745.1 negatively regulates the transcription of genes upregulated by nitrosative stress; transcriptional repressor NsrR 4924389 nsrR 7141213 nsrR Escherichia coli ED1a transcriptional repressor NsrR YP_002400724.1 4923964 D 585397 CDS YP_002400725.1 218692513 7139935 4924428..4926869 1 NC_011745.1 3'-5'exoribonuclease that acts nonspecifically on poly(A), poly(U) and ribosomal RNAs; exoribonuclease R 4926869 rnr 7139935 rnr Escherichia coli ED1a exoribonuclease R YP_002400725.1 4924428 D 585397 CDS YP_002400726.1 218692514 7141442 4926960..4927691 1 NC_011745.1 Specifically methylates the ribose of guanosine 2251 in 23S rRNA; 23S rRNA (guanosine-2'-O-)-methyltransferase 4927691 rlmB 7141442 rlmB Escherichia coli ED1a 23S rRNA (guanosine-2'-O-)-methyltransferase YP_002400726.1 4926960 D 585397 CDS YP_002400727.1 218692515 7141421 4927818..4928219 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4928219 yjfI 7141421 yjfI Escherichia coli ED1a hypothetical protein YP_002400727.1 4927818 D 585397 CDS YP_002400728.1 218692516 7139553 4928238..4928936 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator effector protein 4928936 yjfJ 7139553 yjfJ Escherichia coli ED1a putative transcriptional regulator effector protein YP_002400728.1 4928238 D 585397 CDS YP_002400729.1 218692517 7139554 4928986..4929645 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4929645 yjfK 7139554 yjfK Escherichia coli ED1a hypothetical protein YP_002400729.1 4928986 D 585397 CDS YP_002400730.1 218692518 7139555 4929663..4930061 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4930061 yjfL 7139555 yjfL Escherichia coli ED1a hypothetical protein YP_002400730.1 4929663 D 585397 CDS YP_002400731.1 218692519 7139556 4930071..4930709 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4930709 yjfM 7139556 yjfM Escherichia coli ED1a hypothetical protein YP_002400731.1 4930071 D 585397 CDS YP_002400732.1 218692520 7139552 4931959..4933584 1 NC_011745.1 catalyzes the formation of 3-methylcrotonyl-CoA from isovaleryl-CoA; isovaleryl CoA dehydrogenase 4933584 aidB 7139552 aidB Escherichia coli ED1a isovaleryl CoA dehydrogenase YP_002400732.1 4931959 D 585397 CDS YP_002400733.1 218692521 7143683 complement(4933701..4933976) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4933976 yjfN 7143683 yjfN Escherichia coli ED1a hypothetical protein YP_002400733.1 4933701 R 585397 CDS YP_002400734.1 218692522 7139558 complement(4934125..4934454) 1 NC_011745.1 in Escherichia coli, mutation of this gene affects biofilm maturation, stress response, and motility; putative biofilm stress and motility protein A 4934454 yjfO 7139558 yjfO Escherichia coli ED1a putative biofilm stress and motility protein A YP_002400734.1 4934125 R 585397 CDS YP_002400735.1 218692523 7139559 4934636..4935385 1 NC_011745.1 YjfP; esterase activity towards palmitoyl-CoA and pNP-butyrate in vitro; unknown function and substrate in vivo; esterase 4935385 yjfP 7139559 yjfP Escherichia coli ED1a esterase YP_002400735.1 4934636 D 585397 CDS YP_002400736.1 218692524 7139560 complement(4935382..4936137) 1 NC_011745.1 negative regulator of ulaG and ulaABCDEF; transcriptional repressor UlaR 4936137 ulaR 7139560 ulaR Escherichia coli ED1a transcriptional repressor UlaR YP_002400736.1 4935382 R 585397 CDS YP_002400737.1 218692525 7138893 complement(4936245..4937309) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12644495, 15808744; Product type pe : putative enzyme; putative L-ascorbate 6-phosphate lactonase 4937309 ulaG 7138893 ulaG Escherichia coli ED1a putative L-ascorbate 6-phosphate lactonase YP_002400737.1 4936245 R 585397 CDS YP_002400738.1 218692526 7138892 4937664..4939061 1 NC_011745.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 4939061 ulaA 7138892 ulaA Escherichia coli ED1a PTS system ascorbate-specific transporter subunit IIC YP_002400738.1 4937664 D 585397 CDS YP_002400739.1 218692527 7138886 4939077..4939382 1 NC_011745.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system L-ascorbate-specific transporter subunit IIB 4939382 ulaB 7138886 ulaB Escherichia coli ED1a PTS system L-ascorbate-specific transporter subunit IIB YP_002400739.1 4939077 D 585397 CDS YP_002400740.1 218692528 7138887 4939392..4939856 1 NC_011745.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system L-ascorbate-specific transporter subunit IIA 4939856 ulaC 7138887 ulaC Escherichia coli ED1a PTS system L-ascorbate-specific transporter subunit IIA YP_002400740.1 4939392 D 585397 CDS YP_002400741.1 218692529 7138888 4939870..4940520 1 NC_011745.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase 4940520 ulaD 7138888 ulaD Escherichia coli ED1a 3-keto-L-gulonate-6-phosphate decarboxylase YP_002400741.1 4939870 D 585397 CDS YP_002400742.1 218692530 7138889 complement(4940792..4941640) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9987116; hypothetical protein 4941640 7138889 ECED1_4984 Escherichia coli ED1a hypothetical protein YP_002400742.1 4940792 R 585397 CDS YP_002400743.1 218692531 7139407 complement(4941919..4942422) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4942422 yeeW 7139407 yeeW Escherichia coli ED1a hypothetical protein YP_002400743.1 4941919 R 585397 CDS YP_002400744.1 218692532 7139408 complement(4942419..4942898) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594833; Product type f : factor; toxin of the YeeV-YeeU toxin-antitoxin system 4942898 yeeV 7139408 yeeV Escherichia coli ED1a toxin of the YeeV-YeeU toxin-antitoxin system YP_002400744.1 4942419 R 585397 CDS YP_002400745.1 218692533 7139403 complement(4942843..4943217) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594833; Product type h : extrachromosomal origin; CP4-44 prophage YeeV-YeeU toxin-antitoxin system toxin 4943217 yeeU 7139403 yeeU Escherichia coli ED1a CP4-44 prophage YeeV-YeeU toxin-antitoxin system toxin YP_002400745.1 4942843 R 585397 CDS YP_002400746.1 218692534 7139398 complement(4943297..4943518) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 4943518 yeeT 7139398 yeeT Escherichia coli ED1a hypothetical protein YP_002400746.1 4943297 R 585397 CDS YP_002400747.1 218692535 7139393 complement(4943605..4944096) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11053371; Product type pf : putative factor; putative DNA repair protein; CP4-44 prophage 4944096 yeeS 7139393 yeeS Escherichia coli ED1a putative DNA repair protein; CP4-44 prophage YP_002400747.1 4943605 R 585397 CDS YP_002400748.1 218692536 7139388 complement(4944097..4944435) 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 4944435 7139388 ECED1_4991 Escherichia coli ED1a hypothetical protein YP_002400748.1 4944097 R 585397 CDS YP_002400749.1 218692537 7143627 complement(4944636..4945457) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4945457 7143627 ECED1_4993 Escherichia coli ED1a hypothetical protein YP_002400749.1 4944636 R 585397 CDS YP_002400750.1 218692538 7143628 4945561..4945749 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4945749 7143628 ECED1_4994 Escherichia coli ED1a hypothetical protein YP_002400750.1 4945561 D 585397 CDS YP_002400751.1 218692539 7142358 complement(4945870..4946325) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4946325 7142358 ECED1_4996 Escherichia coli ED1a hypothetical protein YP_002400751.1 4945870 R 585397 CDS YP_002400752.1 218692540 7142361 4947970..4948242 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4948242 7142361 ECED1_4998 Escherichia coli ED1a hypothetical protein YP_002400752.1 4947970 D 585397 CDS YP_002400753.1 218692541 7142362 complement(4948314..4948547) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4948547 7142362 ECED1_4999 Escherichia coli ED1a hypothetical protein YP_002400753.1 4948314 R 585397 CDS YP_002400754.1 218692542 7142363 complement(4948514..4948729) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4948729 7142363 ECED1_5000 Escherichia coli ED1a hypothetical protein YP_002400754.1 4948514 R 585397 CDS YP_002400755.1 218692543 7142364 complement(4948790..4949479) 1 NC_011745.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase 4949479 nanE 7142364 nanE Escherichia coli ED1a N-acetylmannosamine-6-phosphate 2-epimerase YP_002400755.1 4948790 R 585397 CDS YP_002400756.1 218692544 7140344 complement(4949479..4951080) 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1508157; Product type e : enzyme; PTS system glucose-specific enzyme II, ABC component 4951080 ptsG 7140344 ptsG Escherichia coli ED1a PTS system glucose-specific enzyme II, ABC component YP_002400756.1 4949479 R 585397 CDS YP_002400757.1 218692545 7141208 4951202..4952026 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative Transcriptional regulator 4952026 7141208 ECED1_5003 Escherichia coli ED1a putative Transcriptional regulator YP_002400757.1 4951202 D 585397 CDS YP_002400758.1 218692546 7142365 4952260..4952535 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF 1, IS1 4952535 insA 7142365 insA Escherichia coli ED1a transposase ORF 1, IS1 YP_002400758.1 4952260 D 585397 CDS YP_002400759.1 218692547 7141131 4952454..4952957 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF 2, IS1 4952957 7141131 ECED1_5005 Escherichia coli ED1a transposase ORF 2, IS1 YP_002400759.1 4952454 D 585397 CDS YP_002400760.1 218692548 7139372 4953561..4953965 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative transposase 4953965 7139372 ECED1_5008 Escherichia coli ED1a putative transposase YP_002400760.1 4953561 D 585397 CDS YP_002400761.1 218692549 7142367 4953962..4954309 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative transposase ORF2, IS66 family 4954309 7142367 ECED1_5009 Escherichia coli ED1a putative transposase ORF2, IS66 family YP_002400761.1 4953962 D 585397 CDS YP_002400762.1 218692550 7142368 4954358..4955896 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transposase ORF 1, IS66 family 4955896 7142368 ECED1_5010 Escherichia coli ED1a putative transposase ORF 1, IS66 family YP_002400762.1 4954358 D 585397 CDS YP_002400763.1 218692551 7142370 complement(4956276..4957166) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 4957166 7142370 ECED1_5013 Escherichia coli ED1a transposase ORF B, IS629 YP_002400763.1 4956276 R 585397 CDS YP_002400764.1 218692552 7142371 complement(4957163..4957489) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS629 4957489 7142371 ECED1_5014 Escherichia coli ED1a transposase ORF A, IS629 YP_002400764.1 4957163 R 585397 CDS YP_002400765.1 218692553 7142372 complement(4957761..4958513) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4958513 7142372 ECED1_5015 Escherichia coli ED1a hypothetical protein YP_002400765.1 4957761 R 585397 CDS YP_002400766.1 218692554 7142373 complement(4958464..4959879) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase subunit with NAD(P)-binding domain and ferridoxin-like domain 4959879 ykgF 7142373 ykgF Escherichia coli ED1a putative oxidoreductase subunit with NAD(P)-binding domain and ferridoxin-like domain YP_002400766.1 4958464 R 585397 CDS YP_002400767.1 218692555 7140949 complement(4959890..4960609) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4960609 7140949 ECED1_5017 Escherichia coli ED1a hypothetical protein YP_002400767.1 4959890 R 585397 CDS YP_002400768.1 218692556 7142374 complement(4960659..4962215) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; L-lactate permease 4962215 7142374 ECED1_5018 Escherichia coli ED1a L-lactate permease YP_002400768.1 4960659 R 585397 CDS YP_002400769.1 218692557 7142375 4962552..4962743 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; Periplasmic oligopeptide-binding protein (fragment) 4962743 7142375 ECED1_5020 Escherichia coli ED1a Periplasmic oligopeptide-binding protein (fragment) YP_002400769.1 4962552 D 585397 CDS YP_002400770.1 218692558 7142376 4962971..4963246 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 4963246 insA 7142376 insA Escherichia coli ED1a IS1 repressor protein InsA YP_002400770.1 4962971 D 585397 CDS YP_002400771.1 218692559 7142378 4964439..4964678 1 NC_011745.1 Evidence 7 : Gene remnant; hypothetical protein 4964678 7142378 ECED1_5026 Escherichia coli ED1a hypothetical protein YP_002400771.1 4964439 D 585397 CDS YP_002400772.1 218692560 7142379 4964823..4965095 1 NC_011745.1 Evidence 7 : Gene remnant; hypothetical protein 4965095 7142379 ECED1_5027 Escherichia coli ED1a hypothetical protein YP_002400772.1 4964823 D 585397 CDS YP_002400773.1 218692561 7142380 complement(4965329..4965601) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type rc : receptor; Neurotensin receptor R8 4965601 7142380 ECED1_5028 Escherichia coli ED1a Neurotensin receptor R8 YP_002400773.1 4965329 R 585397 CDS YP_002400774.1 218692562 7142381 complement(4965598..4965813) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4965813 7142381 ECED1_5029 Escherichia coli ED1a hypothetical protein YP_002400774.1 4965598 R 585397 CDS YP_002400775.1 218692563 7142382 complement(4965817..4966200) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4966200 7142382 ECED1_5030 Escherichia coli ED1a hypothetical protein YP_002400775.1 4965817 R 585397 CDS YP_002400776.1 218692564 7142383 complement(4966197..4966388) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4966388 7142383 ECED1_5031 Escherichia coli ED1a hypothetical protein YP_002400776.1 4966197 R 585397 CDS YP_002400777.1 218692565 7142384 complement(4966476..4966796) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4966796 7142384 ECED1_5032 Escherichia coli ED1a hypothetical protein YP_002400777.1 4966476 R 585397 CDS YP_002400778.1 218692566 7142385 complement(4967122..4967346) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4967346 7142385 ECED1_5033 Escherichia coli ED1a hypothetical protein YP_002400778.1 4967122 R 585397 CDS YP_002400779.1 218692567 7142386 complement(4967580..4968599) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10678953; Product type prc : putative receptor; Iha adhesin (partial) 4968599 7142386 ECED1_5034 Escherichia coli ED1a Iha adhesin (partial) YP_002400779.1 4967580 R 585397 CDS YP_002400780.1 218692568 7142387 complement(4968569..4968712) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4968712 7142387 ECED1_5035 Escherichia coli ED1a hypothetical protein YP_002400780.1 4968569 R 585397 CDS YP_002400781.1 218692569 7142388 complement(4969073..4969267) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4969267 7142388 ECED1_5036 Escherichia coli ED1a hypothetical protein YP_002400781.1 4969073 R 585397 CDS YP_002400782.1 218692570 7142389 complement(4969319..4969498) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4969498 7142389 ECED1_5037 Escherichia coli ED1a hypothetical protein YP_002400782.1 4969319 R 585397 CDS YP_002400783.1 218692571 7142390 4969606..4969884 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4969884 7142390 ECED1_5038 Escherichia coli ED1a hypothetical protein YP_002400783.1 4969606 D 585397 CDS YP_002400784.1 218692572 7142391 complement(4970139..4970312) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4970312 7142391 ECED1_5039 Escherichia coli ED1a hypothetical protein YP_002400784.1 4970139 R 585397 CDS YP_002400785.1 218692573 7142392 complement(4970570..4971616) 1 NC_011745.1 Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import; ferric transporter ATP-binding subunit 4971616 fbpC 7142392 fbpC Escherichia coli ED1a ferric transporter ATP-binding subunit YP_002400785.1 4970570 R 585397 CDS YP_002400786.1 218692574 7144134 complement(4971628..4973763) 1 NC_011745.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8807793; Product type m : membrane component; permease component of transport system for ferric iron 4973763 fbpB 7144134 fbpB Escherichia coli ED1a permease component of transport system for ferric iron YP_002400786.1 4971628 R 585397 CDS YP_002400787.1 218692575 7144133 complement(4973775..4974806) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative periplasmic ferric iron-binding protein 4974806 afuA 7144133 afuA Escherichia coli ED1a putative periplasmic ferric iron-binding protein YP_002400787.1 4973775 R 585397 CDS YP_002400788.1 218692576 7143670 complement(4974803..4976119) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 3301805, 1569007, 8349544; Product type pr : putative regulator; putative regulatory protein 4976119 7143670 ECED1_5043 Escherichia coli ED1a putative regulatory protein YP_002400788.1 4974803 R 585397 CDS YP_002400789.1 218692577 7142393 complement(4976192..4977733) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1569007; Product type pt : putative transporter; putative sensor histidine protein kinase (uhpB-like) 4977733 7142393 ECED1_5044 Escherichia coli ED1a putative sensor histidine protein kinase (uhpB-like) YP_002400789.1 4976192 R 585397 CDS YP_002400790.1 218692578 7142394 complement(4977733..4978362) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative response regulator 4978362 7142394 ECED1_5045 Escherichia coli ED1a putative response regulator YP_002400790.1 4977733 R 585397 CDS YP_002400791.1 218692579 7142395 complement(4978645..4979826) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative prophage integrase 4979826 7142395 ECED1_5046 Escherichia coli ED1a putative prophage integrase YP_002400791.1 4978645 R 585397 CDS YP_002400792.1 218692580 7142396 4980073..4980816 1 NC_011745.1 UlaE; catalyzes the epimerization of L-ribulose-5-phosphate into L-xylulose-5-phosphate; part of the anaerobic L-ascorbate degradation pathway; L-xylulose 5-phosphate 3-epimerase 4980816 ulaE 7142396 ulaE Escherichia coli ED1a L-xylulose 5-phosphate 3-epimerase YP_002400792.1 4980073 D 585397 CDS YP_002400793.1 218692581 7138890 4980816..4981502 1 NC_011745.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 4981502 sgaE 7138890 sgaE Escherichia coli ED1a L-ribulose-5-phosphate 4-epimerase YP_002400793.1 4980816 D 585397 CDS YP_002400794.1 218692582 7138891 complement(4981632..4981907) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4981907 yjfY 7138891 yjfY Escherichia coli ED1a hypothetical protein YP_002400794.1 4981632 R 585397 CDS YP_002400795.1 218692583 7139561 4982235..4982630 1 NC_011745.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 4982630 rpsF 7139561 rpsF Escherichia coli ED1a 30S ribosomal protein S6 YP_002400795.1 4982235 D 585397 CDS YP_002400796.1 218692584 7140089 4982637..4982951 1 NC_011745.1 binds single-stranded DNA at the primosome assembly site; primosomal replication protein N 4982951 priB 7140089 priB Escherichia coli ED1a primosomal replication protein N YP_002400796.1 4982637 D 585397 CDS YP_002400797.1 218692585 7139120 4982956..4983183 1 NC_011745.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 4983183 rpsR 7139120 rpsR Escherichia coli ED1a 30S ribosomal protein S18 YP_002400797.1 4982956 D 585397 CDS YP_002400798.1 218692586 7140101 4983225..4983674 1 NC_011745.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 4983674 rplI 7140101 rplI Escherichia coli ED1a 50S ribosomal protein L9 YP_002400798.1 4983225 D 585397 CDS YP_002400799.1 218692587 7141458 4984076..4984567 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4984567 7141458 ECED1_5054 Escherichia coli ED1a hypothetical protein YP_002400799.1 4984076 D 585397 CDS YP_002400800.1 218692588 7142397 4984570..4985838 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4985838 7142397 ECED1_5055 Escherichia coli ED1a hypothetical protein YP_002400800.1 4984570 D 585397 CDS YP_002400801.1 218692589 7142398 complement(4985981..4987258) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative Hexuronate transporter 4987258 7142398 ECED1_5056 Escherichia coli ED1a putative Hexuronate transporter YP_002400801.1 4985981 R 585397 CDS YP_002400802.1 218692590 7142399 complement(4987351..4989423) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 4989423 7142399 ECED1_5057 Escherichia coli ED1a putative oxidoreductase YP_002400802.1 4987351 R 585397 CDS YP_002400803.1 218692591 7142400 complement(4989420..4990961) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative CoA transferase 4990961 7142400 ECED1_5058 Escherichia coli ED1a putative CoA transferase YP_002400803.1 4989420 R 585397 CDS YP_002400804.1 218692592 7142401 complement(4990971..4991747) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acyl-CoA hydratase 4991747 7142401 ECED1_5059 Escherichia coli ED1a putative acyl-CoA hydratase YP_002400804.1 4990971 R 585397 CDS YP_002400805.1 218692593 7142402 complement(4991757..4992599) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 4992599 7142402 ECED1_5060 Escherichia coli ED1a hypothetical protein YP_002400805.1 4991757 R 585397 CDS YP_002400806.1 218692594 7142403 complement(4992609..4993400) 1 NC_011745.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-(acyl-carrier-protein) reductase 4993400 7142403 ECED1_5061 Escherichia coli ED1a 3-ketoacyl-(acyl-carrier-protein) reductase YP_002400806.1 4992609 R 585397 CDS YP_002400807.1 218692595 7142404 4993541..4994260 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 4994260 ytfA 7142404 ytfA Escherichia coli ED1a putative transcriptional regulator YP_002400807.1 4993541 D 585397 CDS YP_002400808.1 218692596 7143255 complement(4994244..4994882) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8559074; Product type ps : putative structure; putative cell envelope opacity-associated protein 4994882 ytfB 7143255 ytfB Escherichia coli ED1a putative cell envelope opacity-associated protein YP_002400808.1 4994244 R 585397 CDS YP_002400809.1 218692597 7143256 4995100..4995720 1 NC_011745.1 FKBP-type; rotamase; catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; peptidyl-prolyl cis-trans isomerase 4995720 fklB 7143256 fklB Escherichia coli ED1a peptidyl-prolyl cis-trans isomerase YP_002400809.1 4995100 D 585397 CDS YP_002400810.1 218692598 7144193 4996029..4997432 1 NC_011745.1 involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine; D-alanine/D-serine/glycine permease 4997432 cycA 7144193 cycA Escherichia coli ED1a D-alanine/D-serine/glycine permease YP_002400810.1 4996029 D 585397 CDS YP_002400811.1 218692599 7142097 4997338..4997997 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4997997 7142097 ECED1_5066 Escherichia coli ED1a hypothetical protein YP_002400811.1 4997338 D 585397 CDS YP_002400812.1 218692600 7142405 4998042..4999163 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4999163 7142405 ECED1_5067 Escherichia coli ED1a hypothetical protein YP_002400812.1 4998042 D 585397 CDS YP_002400813.1 218692601 7142406 complement(4999410..5000072) 1 NC_011745.1 Involved in anaerobic NO protection and iron metabolism; iron-sulfur cluster repair di-iron protein 5000072 ytfE 7142406 ytfE Escherichia coli ED1a iron-sulfur cluster repair di-iron protein YP_002400813.1 4999410 R 585397 CDS YP_002400814.1 218692602 7143257 complement(5000180..5001154) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 5001154 ytfF 7143257 ytfF Escherichia coli ED1a hypothetical protein YP_002400814.1 5000180 R 585397 CDS YP_002400815.1 218692603 7143258 complement(5001253..5002113) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14747727; Product type e : enzyme; NAD(P)H:quinone oxidoreductase 5002113 ytfG 7143258 ytfG Escherichia coli ED1a NAD(P)H:quinone oxidoreductase YP_002400815.1 5001253 R 585397 CDS YP_002400816.1 218692604 7143259 5002202..5002582 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20088838; Product type pr : putative regulator; putative transcriptional regulator 5002582 ytfH 7143259 ytfH Escherichia coli ED1a putative transcriptional regulator YP_002400816.1 5002202 D 585397 CDS YP_002400817.1 218692605 7143260 complement(5002711..5004654) 1 NC_011745.1 periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate; bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein 5004654 cpdB 7143260 cpdB Escherichia coli ED1a bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein YP_002400817.1 5002711 R 585397 CDS YP_002400818.1 218692606 7142042 5004844..5005584 1 NC_011745.1 catalyzes the formation of AMP from adenosine-3',5'-bisphosphate; adenosine-3'(2'),5'-bisphosphate nucleotidase 5005584 cysQ 7142042 cysQ Escherichia coli ED1a adenosine-3'(2'),5'-bisphosphate nucleotidase YP_002400818.1 5004844 D 585397 CDS YP_002400819.1 218692607 7143044 complement(5005574..5006131) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9298646; Product type pr : putative regulator; putative transcriptional regulator 5006131 ytfJ 7143044 ytfJ Escherichia coli ED1a putative transcriptional regulator YP_002400819.1 5005574 R 585397 CDS YP_002400820.1 218692608 7143261 5006456..5006662 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5006662 ytfK 7143261 ytfK Escherichia coli ED1a hypothetical protein YP_002400820.1 5006456 D 585397 CDS YP_002400821.1 218692609 7143262 complement(5006740..5008083) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 5008083 ytfL 7143262 ytfL Escherichia coli ED1a hypothetical protein YP_002400821.1 5006740 R 585397 CDS YP_002400822.1 218692610 7143263 complement(5008406..5009044) 1 NC_011745.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A 5009044 msrA 7143263 msrA Escherichia coli ED1a methionine sulfoxide reductase A YP_002400822.1 5008406 R 585397 CDS YP_002400823.1 218692611 7139034 5009250..5010983 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 5010983 ytfM 7139034 ytfM Escherichia coli ED1a hypothetical protein YP_002400823.1 5009250 D 585397 CDS YP_002400824.1 218692612 7143264 5010980..5014759 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5014759 ytfN 7143264 ytfN Escherichia coli ED1a hypothetical protein YP_002400824.1 5010980 D 585397 CDS YP_002400825.1 218692613 7143265 5014762..5015103 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5015103 ytfP 7143265 ytfP Escherichia coli ED1a hypothetical protein YP_002400825.1 5014762 D 585397 CDS YP_002400826.1 218692614 7143266 5015253..5016725 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5016725 7143266 ECED1_5081 Escherichia coli ED1a hypothetical protein YP_002400826.1 5015253 D 585397 CDS YP_002400827.1 218692615 7142407 complement(5017139..5017669) 1 NC_011745.1 catalyzes the hydrolysis of pyrophosphate to phosphate; inorganic pyrophosphatase 5017669 ppa 7142407 ppa Escherichia coli ED1a inorganic pyrophosphatase YP_002400827.1 5017139 R 585397 CDS YP_002400828.1 218692616 7139095 complement(5017641..5017829) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5017829 7139095 ECED1_5083 Escherichia coli ED1a hypothetical protein YP_002400828.1 5017641 R 585397 CDS YP_002400829.1 218692617 7142408 5017981..5018937 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9298646; Product type pt : putative transporter; putative sugar ABC transporter periplasmic-binding protein 5018937 ytfQ 7142408 ytfQ Escherichia coli ED1a putative sugar ABC transporter periplasmic-binding protein YP_002400829.1 5017981 D 585397 CDS YP_002400830.1 218692618 7143267 5019077..5020579 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter ATP-binding protein 5020579 ytfR 7143267 ytfR Escherichia coli ED1a putative sugar ABC transporter ATP-binding protein YP_002400830.1 5019077 D 585397 CDS YP_002400831.1 218692619 7143268 5020569..5021921 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter membrane protein 5021921 ytfT 7143268 ytfT Escherichia coli ED1a putative sugar ABC transporter membrane protein YP_002400831.1 5020569 D 585397 CDS YP_002400832.1 218692620 7143269 complement(5021957..5022955) 1 NC_011745.1 catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate; fructose-1,6-bisphosphatase 5022955 fbp 7143269 fbp Escherichia coli ED1a fructose-1,6-bisphosphatase YP_002400832.1 5021957 R 585397 CDS YP_002400833.1 218692621 7144132 5023131..5024504 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96404780, 2843822, 7984428, 8808921; Product type e : enzyme; UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase 5024504 mpl 7144132 mpl Escherichia coli ED1a UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase YP_002400833.1 5023131 D 585397 CDS YP_002400834.1 218692622 7139015 complement(5024662..5025213) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5025213 yjgA 7139015 yjgA Escherichia coli ED1a hypothetical protein YP_002400834.1 5024662 R 585397 CDS YP_002400835.1 218692623 7139562 5025307..5026659 1 NC_011745.1 protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD; peptidase PmbA 5026659 pmbA 7139562 pmbA Escherichia coli ED1a peptidase PmbA YP_002400835.1 5025307 D 585397 CDS YP_002400836.1 218692624 7139073 5026842..5027228 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1761034, 8499452, 10393541; Product type c : carrier; soluble cytochrome b562 5027228 cybC 7139073 cybC Escherichia coli ED1a soluble cytochrome b562 YP_002400836.1 5026842 D 585397 CDS YP_002400837.1 218692625 7142096 complement(5027273..5027737) 1 NC_011745.1 activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions; anaerobic ribonucleotide reductase-activating protein 5027737 nrdG 7142096 nrdG Escherichia coli ED1a anaerobic ribonucleotide reductase-activating protein YP_002400837.1 5027273 R 585397 CDS YP_002400838.1 218692626 7139924 complement(5027895..5030033) 1 NC_011745.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase 5030033 nrdD 7139924 nrdD Escherichia coli ED1a anaerobic ribonucleoside triphosphate reductase YP_002400838.1 5027895 R 585397 CDS YP_002400839.1 218692627 7139921 complement(5030427..5032082) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90264345, 93302496, 8083158, 8421692; Product type e : enzyme; trehalose-6-phosphate hydrolase 5032082 treC 7139921 treC Escherichia coli ED1a trehalose-6-phosphate hydrolase YP_002400839.1 5030427 R 585397 CDS YP_002400840.1 218692628 7140806 complement(5032132..5033553) 1 NC_011745.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system trehalose(maltose)-specific transporter subunits IIBC 5033553 treB 7140806 treB Escherichia coli ED1a PTS system trehalose(maltose)-specific transporter subunits IIBC YP_002400840.1 5032132 R 585397 CDS YP_002400841.1 218692629 7140805 complement(5033672..5034619) 1 NC_011745.1 regulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon; trehalose repressor 5034619 treR 7140805 treR Escherichia coli ED1a trehalose repressor YP_002400841.1 5033672 R 585397 CDS YP_002400842.1 218692630 7140808 5034998..5037694 1 NC_011745.1 P-type ATPase involved in magnesium influx; magnesium-transporting ATPase MgtA 5037694 mgtA 7140808 mgtA Escherichia coli ED1a magnesium-transporting ATPase MgtA YP_002400842.1 5034998 D 585397 CDS YP_002400843.1 218692631 7142268 complement(5037900..5038286) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12515541, 10493123, 10595546, 9298646; Product type pe : putative enzyme; ketoacid-binding protein 5038286 yjgF 7142268 yjgF Escherichia coli ED1a ketoacid-binding protein YP_002400843.1 5037900 R 585397 CDS YP_002400844.1 218692632 7139565 complement(5038359..5038820) 1 NC_011745.1 involved in the allosteric regulation of aspartate carbamoyltransferase; aspartate carbamoyltransferase regulatory subunit 5038820 pyrI 7139565 pyrI Escherichia coli ED1a aspartate carbamoyltransferase regulatory subunit YP_002400844.1 5038359 R 585397 CDS YP_002400845.1 218692633 7141238 complement(5038833..5039768) 1 NC_011745.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase catalytic subunit 5039768 pyrB 7141238 pyrB Escherichia coli ED1a aspartate carbamoyltransferase catalytic subunit YP_002400845.1 5038833 R 585397 CDS YP_002400846.1 218692634 7141231 complement(5039772..5039906) 1 NC_011745.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide; pyrBI operon leader peptide 5039906 pyrL 7141231 pyrL Escherichia coli ED1a pyrBI operon leader peptide YP_002400846.1 5039772 R 585397 CDS YP_002400847.1 218692635 7141239 complement(5039996..5040550) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative arginine repressor 5040550 7141239 ECED1_5101 Escherichia coli ED1a putative arginine repressor YP_002400847.1 5039996 R 585397 CDS YP_002400848.1 218692636 7142409 complement(5040600..5042048) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5042048 7142409 ECED1_5102 Escherichia coli ED1a hypothetical protein YP_002400848.1 5040600 R 585397 CDS YP_002400849.1 218692637 7142410 complement(5042060..5043091) 1 NC_011745.1 catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway; ornithine carbamoyltransferase 5043091 arcB 7142410 arcB Escherichia coli ED1a ornithine carbamoyltransferase YP_002400849.1 5042060 R 585397 CDS YP_002400850.1 218692638 7142607 complement(5043088..5044044) 1 NC_011745.1 reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 5044044 arcC 7142607 arcC Escherichia coli ED1a carbamate kinase YP_002400850.1 5043088 R 585397 CDS YP_002400851.1 218692639 7142608 complement(5044031..5045254) 1 NC_011745.1 catalyzes the degradation of arginine to citruline and ammonia; arginine deiminase 5045254 7142608 ECED1_5105 Escherichia coli ED1a arginine deiminase YP_002400851.1 5044031 R 585397 CDS YP_002400852.1 218692640 7142411 5045929..5046381 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11115104; hypothetical protein 5046381 yjgK 7142411 yjgK Escherichia coli ED1a hypothetical protein YP_002400852.1 5045929 D 585397 CDS YP_002400853.1 218692641 7139566 complement(5046426..5047430) 1 NC_011745.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; E. coli K12 has two genes, argF and argI, capable of producing functional ornithine carbamoyltransferase; when both are active in the same cell, the two gene products form a family of four hybrid trimeric isoenzymes designated, FFF, FFI, FII, and III; ornithine carbamoyltransferase subunit F 5047430 argI 7139566 argI Escherichia coli ED1a ornithine carbamoyltransferase subunit F YP_002400853.1 5046426 R 585397 CDS YP_002400854.1 218692642 7142616 5047592..5048008 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5048008 yjgD 7142616 yjgD Escherichia coli ED1a hypothetical protein YP_002400854.1 5047592 D 585397 CDS YP_002400855.1 218692643 7139564 complement(5048185..5048688) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acetyltransferase 5048688 yjgM 7139564 yjgM Escherichia coli ED1a putative acetyltransferase YP_002400855.1 5048185 R 585397 CDS YP_002400856.1 218692644 7139567 5048881..5050068 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type m : membrane component; hypothetical protein 5050068 yjgN 7139567 yjgN Escherichia coli ED1a hypothetical protein YP_002400856.1 5048881 D 585397 CDS YP_002400857.1 218692645 7139568 complement(5050115..5052970) 1 NC_011745.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 5052970 valS 7139568 valS Escherichia coli ED1a valyl-tRNA synthetase YP_002400857.1 5050115 R 585397 CDS YP_002400858.1 218692646 7139165 complement(5052970..5053413) 1 NC_011745.1 binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit chi 5053413 holC 7139165 holC Escherichia coli ED1a DNA polymerase III subunit chi YP_002400858.1 5052970 R 585397 CDS YP_002400859.1 218692647 7139912 complement(5053671..5055182) 1 NC_011745.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase 5055182 pepA 7139912 pepA Escherichia coli ED1a leucyl aminopeptidase YP_002400859.1 5053671 R 585397 CDS YP_002400860.1 218692648 7144058 5055449..5056549 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 5056549 yjgP 7144058 yjgP Escherichia coli ED1a hypothetical protein YP_002400860.1 5055449 D 585397 CDS YP_002400861.1 218692649 7139569 5056549..5057631 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 5057631 yjgQ 7139569 yjgQ Escherichia coli ED1a hypothetical protein YP_002400861.1 5056549 D 585397 CDS YP_002400862.1 218692650 7139570 complement(5057793..5059295) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ATPase 5059295 yjgR 7139570 yjgR Escherichia coli ED1a putative ATPase YP_002400862.1 5057793 R 585397 CDS YP_002400863.1 218692651 7139571 complement(5059373..5060371) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9119199, 98324983, 9658018; Product type r : regulator; DNA-binding transcriptional repressor, 5-gluconate-binding 5060371 idnR 7139571 idnR Escherichia coli ED1a DNA-binding transcriptional repressor, 5-gluconate-binding YP_002400863.1 5059373 R 585397 CDS YP_002400864.1 218692652 7140230 complement(5061821..5062585) 1 NC_011745.1 Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate; gluconate 5-dehydrogenase 5062585 idnO 7140230 idnO Escherichia coli ED1a gluconate 5-dehydrogenase YP_002400864.1 5061821 R 585397 CDS YP_002400865.1 218692653 7140227 complement(5062609..5063640) 1 NC_011745.1 NAD-binding; L-idonate 5-dehydrogenase 5063640 idnD 7140227 idnD Escherichia coli ED1a L-idonate 5-dehydrogenase YP_002400865.1 5062609 R 585397 CDS YP_002400866.1 218692654 7140225 5063857..5064420 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87310381, 93139975, 98324983, 9658018, 14832279; Product type e : enzyme; D-gluconate kinase 5064420 idnK 7140225 idnK Escherichia coli ED1a D-gluconate kinase YP_002400866.1 5063857 D 585397 CDS YP_002400867.1 218692655 7140226 complement(5064424..5065443) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12147722; Product type pe : putative enzyme; putative alcohol dehydrogenase, Zn-dependent and NAD(P)-binding 5065443 yjgB 7140226 yjgB Escherichia coli ED1a putative alcohol dehydrogenase, Zn-dependent and NAD(P)-binding YP_002400867.1 5064424 R 585397 CDS YP_002400868.1 218692656 7139563 complement(5065518..5065745) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5065745 7139563 ECED1_5124 Escherichia coli ED1a hypothetical protein YP_002400868.1 5065518 R 585397 CDS YP_002400869.1 218692657 7140600 5065985..5067175 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative integrase; KpLE2 phage-like element 5067175 intB 7140600 intB Escherichia coli ED1a putative integrase; KpLE2 phage-like element YP_002400869.1 5065985 D 585397 CDS YP_002400870.1 218692658 7142413 5068276..5068470 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 5068470 7142413 ECED1_5127 Escherichia coli ED1a hypothetical protein YP_002400870.1 5068276 D 585397 CDS YP_002400871.1 218692659 7142414 5068502..5068831 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5068831 yjgZ 7142414 yjgZ Escherichia coli ED1a hypothetical protein YP_002400871.1 5068502 D 585397 CDS YP_002400872.1 218692660 7139572 complement(5069061..5070077) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15766797, 6281654; Product type h : extrachromosomal origin; IS5 transposase and trans-activator; CP4-44 prophage 5070077 insH 7139572 insH Escherichia coli ED1a IS5 transposase and trans-activator; CP4-44 prophage YP_002400872.1 5069061 R 585397 CDS YP_002400873.1 218692661 7141162 5069937..5070140 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 5070140 7141162 ECED1_5130 Escherichia coli ED1a hypothetical protein YP_002400873.1 5069937 D 585397 CDS YP_002400874.1 218692662 7142415 5070095..5070880 1 NC_011745.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF A, IS100 (fragment) 5070880 7142415 ECED1_5131 Escherichia coli ED1a transposase ORF A, IS100 (fragment) YP_002400874.1 5070095 D 585397 CDS YP_002400875.1 218692663 7142418 complement(5071703..5071891) 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5071891 7142418 ECED1_5134 Escherichia coli ED1a hypothetical protein YP_002400875.1 5071703 R 585397 CDS YP_002400876.1 218692664 7142419 5071863..5072078 1 NC_011745.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5072078 7142419 ECED1_5135 Escherichia coli ED1a hypothetical protein YP_002400876.1 5071863 D 585397 CDS YP_002400877.1 218692665 7142420 complement(5072110..5073402) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5073402 7142420 ECED1_5136 Escherichia coli ED1a hypothetical protein YP_002400877.1 5072110 R 585397 CDS YP_002400878.1 218692666 7142421 complement(5073450..5075453) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14702297; Product type t : transporter; betaine-carnitine-choline transporter family member BetU 5075453 7142421 ECED1_5138 Escherichia coli ED1a betaine-carnitine-choline transporter family member BetU YP_002400878.1 5073450 R 585397 CDS YP_002400879.1 218692667 7142422 complement(5075601..5076419) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS600 5076419 7142422 ECED1_5139 Escherichia coli ED1a transposase ORF B, IS600 YP_002400879.1 5075601 R 585397 CDS YP_002400880.1 218692668 7142423 complement(5076455..5076757) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS600 5076757 insM 7142423 insM Escherichia coli ED1a transposase ORF A, IS600 YP_002400880.1 5076455 R 585397 CDS YP_002400881.1 218692669 7141168 complement(5076938..5077882) 1 NC_011745.1 Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase 5077882 msbB 7141168 msbB Escherichia coli ED1a lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase YP_002400881.1 5076938 R 585397 CDS YP_002400882.1 218692670 7139031 complement(5077947..5078897) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1406277; Product type r : regulator; regulator of virG protein 5078897 virK 7139031 virK Escherichia coli ED1a regulator of virG protein YP_002400882.1 5077947 R 585397 CDS YP_002400883.1 218692671 7139166 complement(5078902..5079990) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Glycosyl transferase 5079990 7139166 ECED1_5143 Escherichia coli ED1a Glycosyl transferase YP_002400883.1 5078902 R 585397 CDS YP_002400884.1 218692672 7142424 complement(5079993..5080814) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative polysaccharide deacetylase 5080814 shf 7142424 shf Escherichia coli ED1a putative polysaccharide deacetylase YP_002400884.1 5079993 R 585397 CDS YP_002400885.1 218692673 7143794 5080979..5081323 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS911 5081323 7143794 ECED1_5145 Escherichia coli ED1a transposase ORF A, IS911 YP_002400885.1 5080979 D 585397 CDS YP_002400886.1 218692674 7141170 5082396..5083919 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative reverse transcriptase-like protein from putative prophage or plasmid 5083919 7141170 ECED1_5147 Escherichia coli ED1a putative reverse transcriptase-like protein from putative prophage or plasmid YP_002400886.1 5082396 D 585397 CDS YP_002400887.1 218692675 7142427 5084414..5084827 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5084827 yjhV 7142427 yjhV Escherichia coli ED1a hypothetical protein YP_002400887.1 5084414 D 585397 CDS YP_002400888.1 218692676 7139578 complement(5085385..5086152) 1 NC_011745.1 Part of the FecBCDE citrate-dependent iron (III) transport system; iron-dicitrate transporter ATP-binding subunit 5086152 fecE 7139578 fecE Escherichia coli ED1a iron-dicitrate transporter ATP-binding subunit YP_002400888.1 5085385 R 585397 CDS YP_002400889.1 218692677 7144151 5085956..5086120 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5086120 7144151 ECED1_5152 Escherichia coli ED1a hypothetical protein YP_002400889.1 5085956 D 585397 CDS YP_002400890.1 218692678 7142428 complement(5086153..5087109) 1 NC_011745.1 Ferric citrate binds FecA and is transported across the outer membrane while transmits a signal across the cytoplasmic membrane protein FecR. FecR transmits a signal across the membrane and activates the cytoplasmic FecI that directs the RNA polymerase to express the fecABCDE operon (which encodes the ferric citrate outer membrane receptor and the ferric citrate ABC transporter), as well as fecIR. FecD is one of two (along with FecC) integral membrane protein components of the iron dicitrate ABC transporter.; iron-dicitrate transporter subunit FecD 5087109 fecD 7142428 fecD Escherichia coli ED1a iron-dicitrate transporter subunit FecD YP_002400890.1 5086153 R 585397 CDS YP_002400891.1 218692679 7144150 complement(5087106..5088104) 1 NC_011745.1 part of the FecBCDE citrate-dependent iron (III) transport system; iron-dicitrate transporter permease subunit 5088104 fecC 7144150 fecC Escherichia coli ED1a iron-dicitrate transporter permease subunit YP_002400891.1 5087106 R 585397 CDS YP_002400892.1 218692680 7144149 complement(5088101..5089003) 1 NC_011745.1 part of the ABC transporter involved in the uptake of citrate-dependent Fe(3+); iron-dicitrate transporter substrate-binding subunit 5089003 fecB 7144149 fecB Escherichia coli ED1a iron-dicitrate transporter substrate-binding subunit YP_002400892.1 5088101 R 585397 CDS YP_002400893.1 218692681 7144148 complement(5089048..5091372) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90105402, 91072220, 92269759, 2836368; Product type t : transporter; ferric citrate outer membrane transporter; KpLE2 phage-like element 5091372 fecA 7144148 fecA Escherichia coli ED1a ferric citrate outer membrane transporter; KpLE2 phage-like element YP_002400893.1 5089048 R 585397 CDS YP_002400894.1 218692682 7144147 complement(5091459..5092412) 1 NC_011745.1 with FecA forms the FecAR signal transduction system; ferric citrate binds FecA and transmits a signal across the outer membrane to FecR. FecR transmits a signal across the cytoplasmic membrane and activates the sigma 70 protein FecI that directs the RNA polymerase to express the fecABCDE operon; fec operon regulator FecR 5092412 fecR 7144147 fecR Escherichia coli ED1a fec operon regulator FecR YP_002400894.1 5091459 R 585397 CDS YP_002400895.1 218692683 7144153 complement(5092409..5092930) 1 NC_011745.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor regulates the genes for iron dicitrate transport; RNA polymerase sigma factor FecI 5092930 fecI 7144153 fecI Escherichia coli ED1a RNA polymerase sigma factor FecI YP_002400895.1 5092409 R 585397 CDS YP_002400896.1 218692684 7144152 5093222..5093497 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF 1, IS1 5093497 insA 7144152 insA Escherichia coli ED1a transposase ORF 1, IS1 YP_002400896.1 5093222 D 585397 CDS YP_002400897.1 218692685 7141133 5093416..5093919 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF2, IS1 5093919 insB 7141133 insB Escherichia coli ED1a transposase ORF2, IS1 YP_002400897.1 5093416 D 585397 CDS YP_002400898.1 218692686 7141158 complement(5095101..5095310) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5095310 7141158 ECED1_5162 Escherichia coli ED1a hypothetical protein YP_002400898.1 5095101 R 585397 CDS YP_002400899.1 218692687 7142429 5095674..5097047 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5097047 7142429 ECED1_5163 Escherichia coli ED1a hypothetical protein YP_002400899.1 5095674 D 585397 CDS YP_002400900.1 218692688 7142432 complement(5098721..5099068) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative transposase ORF2, IS66 family 5099068 7142432 ECED1_5166 Escherichia coli ED1a putative transposase ORF2, IS66 family YP_002400900.1 5098721 R 585397 CDS YP_002400901.1 218692689 7142433 complement(5099065..5099466) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative transposase, IS3 family 5099466 7142433 ECED1_5167 Escherichia coli ED1a putative transposase, IS3 family YP_002400901.1 5099065 R 585397 CDS YP_002400902.1 218692690 7142434 complement(5099800..5100234) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5100234 7142434 ECED1_5168 Escherichia coli ED1a hypothetical protein YP_002400902.1 5099800 R 585397 CDS YP_002400903.1 218692691 7142435 complement(5100222..5100629) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5100629 7142435 ECED1_5169 Escherichia coli ED1a hypothetical protein YP_002400903.1 5100222 R 585397 CDS YP_002400904.1 218692692 7142436 complement(5100883..5101488) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5101488 7142436 ECED1_5170 Escherichia coli ED1a hypothetical protein YP_002400904.1 5100883 R 585397 CDS YP_002400905.1 218692693 7142437 complement(5102199..5102408) 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 1956303, 8145648, 1484495; Product type f : factor; hemolysin expression-modulating protein 5102408 7142437 ECED1_5171 Escherichia coli ED1a hemolysin expression-modulating protein YP_002400905.1 5102199 R 585397 CDS YP_002400906.1 218692694 7142438 5102914..5103315 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; putative Prophage CP4-57 regulatory protein 5103315 7142438 ECED1_5172 Escherichia coli ED1a putative Prophage CP4-57 regulatory protein YP_002400906.1 5102914 D 585397 CDS YP_002400907.1 218692695 7142439 5103374..5103973 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5103973 7142439 ECED1_5173 Escherichia coli ED1a hypothetical protein YP_002400907.1 5103374 D 585397 CDS YP_002400908.1 218692696 7142440 complement(5103959..5104195) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5104195 7142440 ECED1_5174 Escherichia coli ED1a hypothetical protein YP_002400908.1 5103959 R 585397 CDS YP_002400909.1 218692697 7140650 5105467..5106486 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5106486 7140650 ECED1_5175 Escherichia coli ED1a hypothetical protein YP_002400909.1 5105467 D 585397 CDS YP_002400910.1 218692698 7140710 5106557..5107468 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5107468 7140710 ECED1_5176 Escherichia coli ED1a hypothetical protein YP_002400910.1 5106557 D 585397 CDS YP_002400911.1 218692699 7142470 5107795..5110923 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20392470, 97257509, 99212225, 2661530, 9298646; Product type h : extrachromosomal origin; antigen 43 (Ag43) phase-variable biofilm formation autotransporter; CP4-44 prophage 5110923 flu 7142470 flu Escherichia coli ED1a antigen 43 (Ag43) phase-variable biofilm formation autotransporter; CP4-44 prophage YP_002400911.1 5107795 D 585397 CDS YP_002400912.1 218692700 7142151 5111038..5113560 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 5113560 7142151 ECED1_5178 Escherichia coli ED1a hypothetical protein YP_002400912.1 5111038 D 585397 CDS YP_002400913.1 218692701 7140712 5113636..5114091 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5114091 7140712 ECED1_5179 Escherichia coli ED1a hypothetical protein YP_002400913.1 5113636 D 585397 CDS YP_002400914.1 218692702 7140714 complement(5114212..5114400) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5114400 7140714 ECED1_5181 Escherichia coli ED1a hypothetical protein YP_002400914.1 5114212 R 585397 CDS YP_002400915.1 218692703 7140715 5114504..5115325 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5115325 7140715 ECED1_5182 Escherichia coli ED1a hypothetical protein YP_002400915.1 5114504 D 585397 CDS YP_002400916.1 218692704 7140716 5115380..5115865 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7519596; Product type pf : putative factor; putative antirestriction protein (klcA-like) 5115865 7140716 ECED1_5183 Escherichia coli ED1a putative antirestriction protein (klcA-like) YP_002400916.1 5115380 D 585397 CDS YP_002400917.1 218692705 7140717 5115866..5116357 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11053371; Product type pf : putative factor; putative DNA repair protein; CP4-44 prophage 5116357 yeeS 7140717 yeeS Escherichia coli ED1a putative DNA repair protein; CP4-44 prophage YP_002400917.1 5115866 D 585397 CDS YP_002400918.1 218692706 7139389 5116420..5116641 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 5116641 yeeT 7139389 yeeT Escherichia coli ED1a hypothetical protein YP_002400918.1 5116420 D 585397 CDS YP_002400919.1 218692707 7139394 5116641..5116754 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 5116754 7139394 ECED1_5186 Escherichia coli ED1a hypothetical protein YP_002400919.1 5116641 D 585397 CDS YP_002400920.1 218692708 7140718 5116804..5117172 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594833; Product type h : extrachromosomal origin; CP4-44 prophage YeeV-YeeU toxin-antitoxin system toxin 5117172 yeeU 7140718 yeeU Escherichia coli ED1a CP4-44 prophage YeeV-YeeU toxin-antitoxin system toxin YP_002400920.1 5116804 D 585397 CDS YP_002400921.1 218692709 7139399 5117262..5117636 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594833; Product type h : extrachromosomal origin; toxin of the YeeV-YeeU toxin-antitoxin system; CP4-44 prophage 5117636 yeeV 7139399 yeeV Escherichia coli ED1a toxin of the YeeV-YeeU toxin-antitoxin system; CP4-44 prophage YP_002400921.1 5117262 D 585397 CDS YP_002400922.1 218692710 7139404 5117633..5118121 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5118121 yeeW 7139404 yeeW Escherichia coli ED1a hypothetical protein YP_002400922.1 5117633 D 585397 CDS YP_002400923.1 218692711 7139409 5118088..5118330 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5118330 7139409 ECED1_5190 Escherichia coli ED1a hypothetical protein YP_002400923.1 5118088 D 585397 CDS YP_002400924.1 218692712 7140719 5118415..5118567 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5118567 7140719 ECED1_5191 Escherichia coli ED1a hypothetical protein YP_002400924.1 5118415 D 585397 CDS YP_002400925.1 218692713 7141590 complement(5122882..5123862) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5123862 yjhS 7141590 yjhS Escherichia coli ED1a hypothetical protein YP_002400925.1 5122882 R 585397 CDS YP_002400926.1 218692714 7139576 complement(5123927..5125033) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; N-acetylneuraminic acid mutarotase 5125033 yjhT 7139576 yjhT Escherichia coli ED1a N-acetylneuraminic acid mutarotase YP_002400926.1 5123927 R 585397 CDS YP_002400927.1 218692715 7139577 complement(5125053..5125769) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15743943; Product type t : transporter; N-acetylnuraminic acid outer membrane channel protein 5125769 yjhA 7139577 yjhA Escherichia coli ED1a N-acetylnuraminic acid outer membrane channel protein YP_002400927.1 5125053 R 585397 CDS YP_002400928.1 218692716 7139573 complement(5126567..5126974) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5126974 7139573 ECED1_5196 Escherichia coli ED1a hypothetical protein YP_002400928.1 5126567 R 585397 CDS YP_002400929.1 218692717 7140721 5127234..5127836 1 NC_011745.1 inversion of on/off regulator of fimA; tyrosine recombinase 5127836 fimB 7140721 fimB Escherichia coli ED1a tyrosine recombinase YP_002400929.1 5127234 D 585397 CDS YP_002400930.1 218692718 7144182 5128314..5128910 1 NC_011745.1 inversion of on/off regulator of fimA; tyrosine recombinase 5128910 fimE 7144182 fimE Escherichia coli ED1a tyrosine recombinase YP_002400930.1 5128314 D 585397 CDS YP_002400931.1 218692719 7144185 5129391..5129939 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6146599, 6147250, 90220509, 93106965, 2858471, 6123483; Product type s : structure; major type 1 subunit fimbrin 5129939 fimA 7144185 fimA Escherichia coli ED1a major type 1 subunit fimbrin YP_002400931.1 5129391 D 585397 CDS YP_002400932.1 218692720 7144181 5130004..5130543 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12897022, 11673421, 6147250; Product type s : structure; type 1 pilus biosynthesis fimbrial protein 5130543 fimI 7144181 fimI Escherichia coli ED1a type 1 pilus biosynthesis fimbrial protein YP_002400932.1 5130004 D 585397 CDS YP_002400933.1 218692721 7144186 5130580..5131305 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20450729, 90220509, 93155127, 93391362, 1363735, 8104335, 8636962, 9783748; Product type f : factor; chaperone, periplasmic 5131305 fimC 7144186 fimC Escherichia coli ED1a chaperone, periplasmic YP_002400933.1 5130580 D 585397 CDS YP_002400934.1 218692722 7144183 5131367..5133103 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1970114, 89056689, 93155127, 93391362, 1971261, 2890081, 2900235, 790547; Product type s : structure; outer membrane usher protein FimD/type 1 fimbriae minor component 5133103 fimD-fimH 7144183 fimD-fimH Escherichia coli ED1a outer membrane usher protein FimD/type 1 fimbriae minor component YP_002400934.1 5131367 D 585397 CDS YP_002400935.1 218692723 7143001 5133832..5135016 1 NC_011745.1 catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate; mannonate dehydratase 5135016 uxuA 7143001 uxuA Escherichia coli ED1a mannonate dehydratase YP_002400935.1 5133832 D 585397 CDS YP_002400936.1 218692724 7139158 5135097..5136557 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 73203083, 77222076, 14401695; Product type e : enzyme; D-mannonate oxidoreductase, NAD-binding 5136557 uxuB 7139158 uxuB Escherichia coli ED1a D-mannonate oxidoreductase, NAD-binding YP_002400936.1 5135097 D 585397 CDS YP_002400937.1 218692725 7139159 5136772..5137545 1 NC_011745.1 regulates the expression of uxuBA; DNA-binding transcriptional repressor UxuR 5137545 uxuR 7139159 uxuR Escherichia coli ED1a DNA-binding transcriptional repressor UxuR YP_002400937.1 5136772 D 585397 CDS YP_002400938.1 218692726 7139160 complement(5137674..5138954) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 5138954 yjiN 7139160 yjiN Escherichia coli ED1a hypothetical protein YP_002400938.1 5137674 R 585397 CDS YP_002400939.1 218692727 7139580 5139139..5140059 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative transposase 5140059 7139580 ECED1_5208 Escherichia coli ED1a putative transposase YP_002400939.1 5139139 D 585397 CDS YP_002400940.1 218692728 7140722 5140253..5140324 1 NC_011745.1 Evidence 6 : Doubtful CDS; hypothetical protein 5140324 7140722 ECED1_5209 Escherichia coli ED1a hypothetical protein YP_002400940.1 5140253 D 585397 CDS YP_002400941.1 218692729 7140723 5140339..5142546 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5142546 7140723 ECED1_5210 Escherichia coli ED1a hypothetical protein YP_002400941.1 5140339 D 585397 CDS YP_002400942.1 218692730 7140724 complement(5142593..5142991) 1 NC_011745.1 involved in the degradation of RNA; may be involved in the recycling of RNA during the SOS response; endoribonuclease SymE 5142991 yjiW 7140724 yjiW Escherichia coli ED1a endoribonuclease SymE YP_002400942.1 5142593 R 585397 CDS YP_002400943.1 218692731 7141355 complement(5143155..5144909) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9108149, 2642743; Product type e : enzyme; Type I restriction enzyme EcoAI specificity protein (S protein) (S.EcoAI) 5144909 hsdS 7141355 hsdS Escherichia coli ED1a Type I restriction enzyme EcoAI specificity protein (S protein) (S.EcoAI) YP_002400943.1 5143155 R 585397 CDS YP_002400944.1 218692732 7140165 complement(5144909..5146414) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8412658, 1409708; Product type e : enzyme; Type I restriction enzyme EcoEI M protein (M.EcoEI) 5146414 hsdM 7140165 hsdM Escherichia coli ED1a Type I restriction enzyme EcoEI M protein (M.EcoEI) YP_002400944.1 5144909 R 585397 CDS YP_002400945.1 218692733 7140163 complement(5146445..5148877) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9837717, 10373579, 10733903, 8412658; Product type e : enzyme; Type I restriction enzyme EcoAI R protein (R.EcoAI) 5148877 hsdR 7140163 hsdR Escherichia coli ED1a Type I restriction enzyme EcoAI R protein (R.EcoAI) YP_002400945.1 5146445 R 585397 CDS YP_002400946.1 218692734 7140725 5149509..5150807 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5150807 7140725 ECED1_5216 Escherichia coli ED1a hypothetical protein YP_002400946.1 5149509 D 585397 CDS YP_002400947.1 218692735 7140726 complement(5150876..5151832) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14696199; Product type pe : putative enzyme; putative GTP-binding protein YjiA 5151832 yjiA 7140726 yjiA Escherichia coli ED1a putative GTP-binding protein YjiA YP_002400947.1 5150876 R 585397 CDS YP_002400948.1 218692736 7139579 complement(5151843..5152046) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5152046 yjiX 7139579 yjiX Escherichia coli ED1a hypothetical protein YP_002400948.1 5151843 R 585397 CDS YP_002400949.1 218692737 7139582 complement(5152164..5154314) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 5154314 yjiY 7139582 yjiY Escherichia coli ED1a hypothetical protein YP_002400949.1 5152164 R 585397 CDS YP_002400950.1 218692738 7139583 5154691..5156355 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20015410, 89034150, 91317710, 10466731, 2033064, 6213619, 6402709, 8384293; Product type r : regulator; methyl-accepting chemotaxis protein I, serine sensor receptor 5156355 tsr 7139583 tsr Escherichia coli ED1a methyl-accepting chemotaxis protein I, serine sensor receptor YP_002400950.1 5154691 D 585397 CDS YP_002400951.1 218692739 7140836 complement(5156398..5157669) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative C4-dicarboxylate transporter, large permease (dctM-like) 5157669 7140836 ECED1_5221 Escherichia coli ED1a putative C4-dicarboxylate transporter, large permease (dctM-like) YP_002400951.1 5156398 R 585397 CDS YP_002400952.1 218692740 7140727 complement(5157666..5158139) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative tripartite ATP-independent periplasmic transporter (dctQ-like) 5158139 7140727 ECED1_5222 Escherichia coli ED1a putative tripartite ATP-independent periplasmic transporter (dctQ-like) YP_002400952.1 5157666 R 585397 CDS YP_002400953.1 218692741 7140728 complement(5158203..5159174) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative C4-dicarboxylate-binding periplasmic protein (dctP-like) 5159174 7140728 ECED1_5223 Escherichia coli ED1a putative C4-dicarboxylate-binding periplasmic protein (dctP-like) YP_002400953.1 5158203 R 585397 CDS YP_002400954.1 218692742 7140729 5159844..5161517 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative Na(+)/H(+) exchanger 5161517 7140729 ECED1_5224 Escherichia coli ED1a putative Na(+)/H(+) exchanger YP_002400954.1 5159844 D 585397 CDS YP_002400955.1 218692743 7140730 complement(5161688..5162593) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 5162593 yjjM 7140730 yjjM Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002400955.1 5161688 R 585397 CDS YP_002400956.1 218692744 7139590 5162732..5163754 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase, Zn-dependent and NAD(P)-binding 5163754 yjjN 7139590 yjjN Escherichia coli ED1a putative oxidoreductase, Zn-dependent and NAD(P)-binding YP_002400956.1 5162732 D 585397 CDS YP_002400957.1 218692745 7139591 complement(5163891..5166182) 1 NC_011745.1 catalyzes the transfer of phosphoglycerol to the glucan backbone; phosphoglycerol transferase I 5166182 mdoB 7139591 mdoB Escherichia coli ED1a phosphoglycerol transferase I YP_002400957.1 5163891 R 585397 CDS YP_002400958.1 218692746 7142222 complement(5166436..5166930) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5166930 yjjA 7142222 yjjA Escherichia coli ED1a hypothetical protein YP_002400958.1 5166436 R 585397 CDS YP_002400959.1 218692747 7139584 complement(5166979..5167716) 1 NC_011745.1 acts to load the DnaB helicase onto the initiation site during DNA replication; DNA replication protein DnaC 5167716 dnaC 7139584 dnaC Escherichia coli ED1a DNA replication protein DnaC YP_002400959.1 5166979 R 585397 CDS YP_002400960.1 218692748 7140504 complement(5167719..5168258) 1 NC_011745.1 This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'; primosomal protein DnaI 5168258 dnaT 7140504 dnaT Escherichia coli ED1a primosomal protein DnaI YP_002400960.1 5167719 R 585397 CDS YP_002400961.2 229598868 7140511 complement(5168366..5168839) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 5168839 yjjB 7140511 yjjB Escherichia coli ED1a hypothetical protein YP_002400961.2 5168366 R 585397 CDS YP_002400962.1 218692750 7139585 complement(5168830..5169600) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 5169600 yjjP 7139585 yjjP Escherichia coli ED1a hypothetical protein YP_002400962.1 5168830 R 585397 CDS YP_002400963.1 218692751 7139592 5170267..5170542 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF 1, IS1 5170542 insA 7139592 insA Escherichia coli ED1a transposase ORF 1, IS1 YP_002400963.1 5170267 D 585397 CDS YP_002400964.1 218692752 7141134 5170461..5170964 1 NC_011745.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF2, IS1 5170964 insB 7141134 insB Escherichia coli ED1a transposase ORF2, IS1 YP_002400964.1 5170461 D 585397 CDS YP_002400965.1 218692753 7141159 5170997..5171722 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 5171722 yjjQ 7141159 yjjQ Escherichia coli ED1a putative DNA-binding transcriptional regulator YP_002400965.1 5170997 D 585397 CDS YP_002400966.1 218692754 7139547 5171734..5172357 1 NC_011745.1 regulator for the transport and utilization of the aromatic beta-glucosides arbutin and silicin; DNA-binding transcriptional activator BglJ 5172357 bglJ 7139547 bglJ Escherichia coli ED1a DNA-binding transcriptional activator BglJ YP_002400966.1 5171734 D 585397 CDS YP_002400967.1 218692755 7140448 complement(5172395..5173183) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11931550, 14756576, 3323834, 9990318; Product type c : carrier; ferric iron reductase involved in ferric hydroximate transport 5173183 fhuF 7140448 fhuF Escherichia coli ED1a ferric iron reductase involved in ferric hydroximate transport YP_002400967.1 5172395 R 585397 CDS YP_002400968.1 218692756 7144174 5173213..5173560 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5173560 7144174 ECED1_5238 Escherichia coli ED1a hypothetical protein YP_002400968.1 5173213 D 585397 CDS YP_002400969.1 218692757 7140731 5173416..5173571 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5173571 7140731 ECED1_5239 Escherichia coli ED1a hypothetical protein YP_002400969.1 5173416 D 585397 CDS YP_002400970.1 218692758 7140601 complement(5174121..5175152) 1 NC_011745.1 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit; 16S ribosomal RNA m2G1207 methyltransferase 5175152 rsmC 7140601 rsmC Escherichia coli ED1a 16S ribosomal RNA m2G1207 methyltransferase YP_002400970.1 5174121 R 585397 CDS YP_002400971.1 218692759 7140115 5175255..5175668 1 NC_011745.1 with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit psi 5175668 holD 7140115 holD Escherichia coli ED1a DNA polymerase III subunit psi YP_002400971.1 5175255 D 585397 CDS YP_002400972.1 218692760 7139913 5175637..5176083 1 NC_011745.1 alanine acetyltransferase that specifically acetylates ribosomal protein S18; ribosomal-protein-alanine N-acetyltransferase 5176083 rimI 7139913 rimI Escherichia coli ED1a ribosomal-protein-alanine N-acetyltransferase YP_002400972.1 5175637 D 585397 CDS YP_002400973.1 218692761 7141416 5176098..5176775 1 NC_011745.1 manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily; nucleotidase 5176775 yjjG 7141416 yjjG Escherichia coli ED1a nucleotidase YP_002400973.1 5176098 D 585397 CDS YP_002400974.1 218692762 7139586 5176866..5178455 1 NC_011745.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 5178455 prfC 7139586 prfC Escherichia coli ED1a peptide chain release factor 3 YP_002400974.1 5176866 D 585397 CDS YP_002400975.1 218692763 7139117 5178848..5179453 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1317380, 8253679, 9298646, 9600841; Product type cp : cell process; periplasmic protein 5179453 osmY 7139117 osmY Escherichia coli ED1a periplasmic protein YP_002400975.1 5178848 D 585397 CDS YP_002400976.1 218692764 7139990 5179562..5179741 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5179741 ytjA 7139990 ytjA Escherichia coli ED1a hypothetical protein YP_002400976.1 5179562 D 585397 CDS YP_002400977.1 218692765 7143270 5179863..5180936 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative esterase 5180936 yjjU 7143270 yjjU Escherichia coli ED1a putative esterase YP_002400977.1 5179863 D 585397 CDS YP_002400978.1 218692766 7142028 5180933..5181712 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative deoxyribonuclease YjjV 5181712 yjjV 7142028 yjjV Escherichia coli ED1a putative deoxyribonuclease YjjV YP_002400978.1 5180933 D 585397 CDS YP_002400979.1 218692767 7140940 complement(5181929..5182792) 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative pyruvate formate lyase activating enzyme 5182792 yjjW 7140940 yjjW Escherichia coli ED1a putative pyruvate formate lyase activating enzyme YP_002400979.1 5181929 R 585397 CDS YP_002400980.1 218692768 7140941 complement(5182764..5184314) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5184314 yjjI 7140941 yjjI Escherichia coli ED1a hypothetical protein YP_002400980.1 5182764 R 585397 CDS YP_002400981.1 218692769 7139587 5184572..5185351 1 NC_011745.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 5185351 deoC 7139587 deoC Escherichia coli ED1a deoxyribose-phosphate aldolase YP_002400981.1 5184572 D 585397 CDS YP_002400982.1 218692770 7143091 5185429..5186751 1 NC_011745.1 Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate; thymidine phosphorylase 5186751 deoA 7143091 deoA Escherichia coli ED1a thymidine phosphorylase YP_002400982.1 5185429 D 585397 CDS YP_002400983.1 218692771 7143089 5186803..5188026 1 NC_011745.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 5188026 deoB 7143089 deoB Escherichia coli ED1a phosphopentomutase YP_002400983.1 5186803 D 585397 CDS YP_002400984.1 218692772 7143090 5188083..5188802 1 NC_011745.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 5188802 deoD 7143090 deoD Escherichia coli ED1a purine nucleoside phosphorylase YP_002400984.1 5188083 D 585397 CDS YP_002400985.1 218692773 7143092 5188969..5190300 1 NC_011745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; hypothetical protein 5190300 yjjJ 7143092 yjjJ Escherichia coli ED1a hypothetical protein YP_002400985.1 5188969 D 585397 CDS YP_002400986.1 218692774 7139588 complement(5190301..5191317) 1 NC_011745.1 Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl on the lipoate-dependent enzymes. Creates an amide linkage that joins the free carboxyl group of lipoic acid to the epsilon-amino group of a specific lysine residue in lipoyl domain of apoproteins; lipoate-protein ligase A 5191317 lplA 7139588 lplA Escherichia coli ED1a lipoate-protein ligase A YP_002400986.1 5190301 R 585397 CDS YP_002400987.1 218692775 7141913 complement(5191345..5191989) 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2684780; hypothetical protein 5191989 ytjB 7141913 ytjB Escherichia coli ED1a hypothetical protein YP_002400987.1 5191345 R 585397 CDS YP_002400988.1 218692776 7143271 5192095..5193063 1 NC_011745.1 catalyzes the formation of serine from O-phosphoserine; phosphoserine phosphatase 5193063 serB 7143271 serB Escherichia coli ED1a phosphoserine phosphatase YP_002400988.1 5192095 D 585397 CDS YP_002400989.1 218692777 7141398 5193112..5194494 1 NC_011745.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 5194494 radA 7141398 radA Escherichia coli ED1a DNA repair protein RadA YP_002400989.1 5193112 D 585397 CDS YP_002400990.1 218692778 7141250 5194515..5195747 1 NC_011745.1 catalyzes the formation of NAD(+) from nicotinamide ribonucleotide; nicotinamide-nucleotide adenylyltransferase 5195747 nadR 7141250 nadR Escherichia coli ED1a nicotinamide-nucleotide adenylyltransferase YP_002400990.1 5194515 D 585397 CDS YP_002400991.1 218692779 7140335 5195761..5196171 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5196171 7140335 ECED1_5262 Escherichia coli ED1a hypothetical protein YP_002400991.1 5195761 D 585397 CDS YP_002400992.1 218692780 7140733 5196173..5196457 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5196457 7140733 ECED1_5263 Escherichia coli ED1a hypothetical protein YP_002400992.1 5196173 D 585397 CDS YP_002400993.1 218692781 7140734 complement(5196513..5198180) 1 NC_011745.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; putative ABC transporter ATP-binding protein 5198180 yjjK 7140734 yjjK Escherichia coli ED1a putative ABC transporter ATP-binding protein YP_002400993.1 5196513 R 585397 CDS YP_002400994.1 218692782 7139589 5198387..5200324 1 NC_011745.1 catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan; lytic murein transglycosylase 5200324 slt 7139589 slt Escherichia coli ED1a lytic murein transglycosylase YP_002400994.1 5198387 D 585397 CDS YP_002400995.1 218692783 7143804 5200414..5200740 1 NC_011745.1 When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription; Trp operon repressor 5200740 trpR 7143804 trpR Escherichia coli ED1a Trp operon repressor YP_002400995.1 5200414 D 585397 CDS YP_002400996.1 218692784 7140825 complement(5200813..5201349) 1 NC_011745.1 pyrophosphatase; has activity against dUTP and dITP; the crystal structure of the Vibrio protein showed similarity to Methanococcus janaschii Mj0226; in Vibrio cholerae this gene is part of the Mba operon that is involved in regulation and maintenance of biofilms; in Escherichia coli overexpression of this gene leads to resistance to an HMP analog; NTPase 5201349 yjjX 7140825 yjjX Escherichia coli ED1a NTPase YP_002400996.1 5200813 R 585397 CDS YP_002400997.1 218692785 7140942 5201392..5202039 1 NC_011745.1 catalyzes reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate; phosphoglycerate mutase 5202039 ytjC 7140942 ytjC Escherichia coli ED1a phosphoglycerate mutase YP_002400997.1 5201392 D 585397 CDS YP_002400998.1 218692786 7143272 complement(5202036..5202905) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20264525, 20309711, 93194823, 96405618, 8449900; Product type r : regulator; DNA-binding transcriptional activator 5202905 rob 7143272 rob Escherichia coli ED1a DNA-binding transcriptional activator YP_002400998.1 5202036 R 585397 CDS YP_002400999.1 218692787 7141444 5203116..5203589 1 NC_011745.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3531171, 8449900; hypothetical protein 5203589 creA 7141444 creA Escherichia coli ED1a hypothetical protein YP_002400999.1 5203116 D 585397 CDS YP_002401000.1 218692788 7142050 5203602..5204291 1 NC_011745.1 response regulator in two-component regulatory system with CreC; CreB protein is phosphorylated by sensor protein phospho-CreC; involved in catabolic regulation; DNA-binding response regulator CreB 5204291 creB 7142050 creB Escherichia coli ED1a DNA-binding response regulator CreB YP_002401000.1 5203602 D 585397 CDS YP_002401001.1 218692789 7142051 5204291..5205715 1 NC_011745.1 part of a two-component regulatory system with CreB or PhoB; involved in catabolic regulation; sensory histidine kinase CreC 5205715 creC 7142051 creC Escherichia coli ED1a sensory histidine kinase CreC YP_002401001.1 5204291 D 585397 CDS YP_002401002.1 218692790 7142052 5205773..5207125 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88216172, 2835585, 2984198, 3531171; Product type m : membrane component; hypothetical protein 5207125 creD 7142052 creD Escherichia coli ED1a hypothetical protein YP_002401002.1 5205773 D 585397 CDS YP_002401003.1 218692791 7142053 complement(5207185..5207901) 1 NC_011745.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15028693, 21167794, 21317451, 91008980, 91358353, 92380937, 9514749, 9632255, 2984198, 7565118, 9298646; Product type r : regulator; two-component response regulator 5207901 arcA 7142053 arcA Escherichia coli ED1a two-component response regulator YP_002401003.1 5207185 R 585397 CDS YP_002401004.1 218692792 7142605 5208537..5209223 1 NC_011745.1 member of the SPOUT superfamily of methyltransferases; putative RNA methyltransferase 5209223 yjtD 7142605 yjtD Escherichia coli ED1a putative RNA methyltransferase YP_002401004.1 5208537 D 585397 CDS YP_002401005.1 218692793 7140943 5209437..5209502 1 NC_011745.1 involved in threonine biosynthesis; controls the expression of the thrLABC operon; thr operon leader peptide 5209502 thrL 7140943 thrL Escherichia coli ED1a thr operon leader peptide YP_002401005.1 5209437 D 585397 CDS