-- dump date 20140619_082047 -- class Genbank::Feature -- table feature -- table main -- field 1 id -- field 2 type -- field 3 name -- field 4 contig -- field 5 start_pos -- field 6 end_pos -- field 7 strand -- field 8 description -- field 9 chrom_position -- field 10 organism -- field 11 GeneID -- header -- id type name contig start_pos end_pos strand description chrom_position organism GeneID 585397000001 SEQ_END SEQ_END NC_011745.1 5209548 5209548 DR NC_011745.1; contig end 5209548..5209548 Escherichia coli ED1a YP_002396091.1 CDS thrA NC_011745.1 35 2497 D multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartokinase I/homoserine dehydrogenase I 35..2497 Escherichia coli ED1a 7143201 YP_002396092.1 CDS thrB NC_011745.1 2499 3431 D catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 2499..3431 Escherichia coli ED1a 7141551 YP_002396093.1 CDS thrC NC_011745.1 3432 4718 D catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 3432..4718 Escherichia coli ED1a 7141552 YP_002396094.1 CDS yaaX NC_011745.1 4932 5228 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4932..5228 Escherichia coli ED1a 7141553 YP_002396095.1 CDS yaaA NC_011745.1 5278 6054 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5278..6054) Escherichia coli ED1a 7143358 YP_002396096.1 CDS yaaJ NC_011745.1 6124 7554 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative amino acid sodium/proton transporter complement(6124..7554) Escherichia coli ED1a 7139220 YP_002396097.1 CDS talB NC_011745.1 7833 8786 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8332529, 92334977, 11298760, 7592346, 8805555, 9007983, 9298646; Product type e : enzyme; transaldolase B 7833..8786 Escherichia coli ED1a 7143356 YP_002396098.1 CDS mogA NC_011745.1 8901 9488 D forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MogA 8901..9488 Escherichia coli ED1a 7141507 YP_002396099.1 CDS yaaH NC_011745.1 9693 10259 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(9693..10259) Escherichia coli ED1a 7139011 YP_002396100.1 CDS htpY NC_011745.1 10408 11121 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8478327; Product type r : regulator; hypothetical protein complement(10408..11121) Escherichia coli ED1a 7141407 YP_002396101.1 CDS yaaI NC_011745.1 11147 11551 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(11147..11551) Escherichia coli ED1a 7140174 YP_002396102.1 CDS dnaK NC_011745.1 11923 13839 D heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 11923..13839 Escherichia coli ED1a 7143355 YP_002396103.1 CDS dnaJ NC_011745.1 13928 15058 D chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 13928..15058 Escherichia coli ED1a 7140743 YP_002396104.1 CDS ECED1_0015 NC_011745.1 15930 16691 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 15930..16691 Escherichia coli ED1a 7143819 YP_002396105.1 CDS ECED1_0016 NC_011745.1 16675 18204 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Cerebroside-sulfatase 16675..18204 Escherichia coli ED1a 7142828 YP_002396106.1 CDS ECED1_0017 NC_011745.1 18327 19592 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 18327..19592 Escherichia coli ED1a 7142829 YP_002396107.1 CDS nhaA NC_011745.1 19827 20993 D exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH; pH-dependent sodium/proton antiporter 19827..20993 Escherichia coli ED1a 7142830 YP_002396108.1 CDS nhaR NC_011745.1 21053 21958 D Na+/H+ antiporter regulatory protein; activates the genes nhaA and osmC; transcriptional activator NhaR 21053..21958 Escherichia coli ED1a 7140382 YP_002396109.1 CDS rpsT NC_011745.1 22054 22317 R binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 complement(22054..22317) Escherichia coli ED1a 7140384 YP_002396110.1 CDS yaaY NC_011745.1 22420 22638 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 22420..22638 Escherichia coli ED1a 7140103 YP_002396111.1 CDS ribF NC_011745.1 22646 23587 D catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 22646..23587 Escherichia coli ED1a 7143359 YP_002396112.1 CDS ileS NC_011745.1 23630 26446 D IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 23630..26446 Escherichia coli ED1a 7141412 YP_002396113.1 CDS lspA NC_011745.1 26446 26940 D lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 26446..26940 Escherichia coli ED1a 7140234 YP_002396114.1 CDS fkpB NC_011745.1 27048 27497 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 97332650, 2011499; Product type e : enzyme; FKBP-type peptidyl-prolyl cis-trans isomerase 27048..27497 Escherichia coli ED1a 7141927 YP_002396115.1 CDS ispH NC_011745.1 27499 28449 D catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 27499..28449 Escherichia coli ED1a 7144195 YP_002396116.1 CDS rihC NC_011745.1 28515 29429 D catalyzes the hydrolysis of both purine and pyrimidine ribonucleosides; ribonucleoside hydrolase RihC 28515..29429 Escherichia coli ED1a 7142468 YP_002396117.1 CDS ECED1_0028 NC_011745.1 29452 29817 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 29452..29817 Escherichia coli ED1a 7141415 YP_002396118.1 CDS dapB NC_011745.1 29978 30799 D catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 29978..30799 Escherichia coli ED1a 7142831 YP_002396119.1 CDS carA NC_011745.1 31255 32403 D catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 31255..32403 Escherichia coli ED1a 7143063 YP_002396120.1 CDS carB NC_011745.1 32421 35642 D four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 32421..35642 Escherichia coli ED1a 7139306 YP_002396121.1 CDS ECED1_0032 NC_011745.1 35650 35868 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7815937, 6308632; hypothetical protein complement(35650..35868) Escherichia coli ED1a 7139307 YP_002396122.1 CDS caiF NC_011745.1 35903 36298 D regulator of carnitine metabolism; induces the caiTABCDE and fixABCX operons; DNA-binding transcriptional activator CaiF 35903..36298 Escherichia coli ED1a 7142832 YP_002396123.1 CDS caiE NC_011745.1 36417 37007 R involved in the synthesis of a cofactor required for carnitine dehydratase and carnitine racemase activities; carnitine operon protein CaiE complement(36417..37007) Escherichia coli ED1a 7140485 YP_002396124.2 CDS caiD NC_011745.1 37013 37798 R catalyzes the dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA; carnitinyl-CoA dehydratase complement(37013..37798) Escherichia coli ED1a 7140484 YP_002396125.1 CDS caiC NC_011745.1 37904 39472 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15731894, 97189569, 7815937; Product type e : enzyme; putative crotonobetaine/carnitine-CoA ligase complement(37904..39472) Escherichia coli ED1a 7140483 YP_002396126.1 CDS caiB NC_011745.1 39530 40747 R catalyzes formation of L-carnitinyl-CoA by transfering the CoA moiety from gamma-butyrobetainyl-CoA, also catalyzes the formation of crotonobetainyl-CoA by transfer of CoA from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine; crotonobetainyl-CoA:carnitine CoA-transferase complement(39530..40747) Escherichia coli ED1a 7140482 YP_002396127.1 CDS caiA NC_011745.1 40875 42017 R catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA; crotonobetainyl-CoA dehydrogenase complement(40875..42017) Escherichia coli ED1a 7140481 YP_002396128.1 CDS caiT NC_011745.1 42048 43562 R catalyzes the exchange of L-carnitine for gamma-butyrobetaine in carnitine metabolism; L-carnitine/gamma-butyrobetaine antiporter complement(42048..43562) Escherichia coli ED1a 7140480 YP_002396129.1 CDS fixA NC_011745.1 44036 44806 D required for anaerobic carnitine reduction, may act to transfer electrons to crotonobetaine reductase; putative electron transfer flavoprotein FixA 44036..44806 Escherichia coli ED1a 7141101 YP_002396130.1 CDS fixB NC_011745.1 44821 45762 D involved in electron transfer during carnitine metabolism; putative electron transfer flavoprotein FixB 44821..45762 Escherichia coli ED1a 7144189 YP_002396131.1 CDS fixC NC_011745.1 45813 47099 D FAD/NAD(P)-binding domain; possibly part of an electron transfer system required for anaerobic carnitine reduction; putative oxidoreductase FixC 45813..47099 Escherichia coli ED1a 7144190 YP_002396132.1 CDS fixX NC_011745.1 47096 47383 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96066354, 12081978; Product type pc : putative carrier; putative 4Fe-4S ferredoxin 47096..47383 Escherichia coli ED1a 7144191 YP_002396133.1 CDS yaaU NC_011745.1 47442 48773 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 47442..48773 Escherichia coli ED1a 7144192 YP_002396134.1 CDS kefF NC_011745.1 48881 49411 D Required for full activity of KefC, a potassium-proton antiporter; glutathione-regulated potassium-efflux system ancillary protein KefF 48881..49411 Escherichia coli ED1a 7143357 YP_002396135.1 CDS kefC NC_011745.1 49404 51266 D transport system that facilitates potassium-efflux; glutathione-regulated potassium-efflux system protein KefC 49404..51266 Escherichia coli ED1a 7142508 YP_002396136.1 CDS folA NC_011745.1 51458 51937 D catalyzes the reduction of dihydrofolate to tetrahydrofolate; dihydrofolate reductase 51458..51937 Escherichia coli ED1a 7142507 YP_002396137.1 CDS ECED1_0048 NC_011745.1 52023 52256 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative antitoxin of gyrase inhibiting toxin-antitoxin system 52023..52256 Escherichia coli ED1a 7142155 YP_002396138.1 CDS ECED1_0049 NC_011745.1 52259 52573 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative toxin of gyrase inhibiting toxin-antitoxin system 52259..52573 Escherichia coli ED1a 7142833 YP_002396139.1 CDS apaH NC_011745.1 52570 53418 R hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; diadenosine tetraphosphatase complement(52570..53418) Escherichia coli ED1a 7142834 YP_002396140.1 CDS apaG NC_011745.1 53425 53802 R protein associated with Co2+ and Mg2+ efflux; ApaG protein complement(53425..53802) Escherichia coli ED1a 7142589 YP_002396141.1 CDS ksgA NC_011745.1 53805 54626 R catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase complement(53805..54626) Escherichia coli ED1a 7142588 YP_002396142.1 CDS pdxA NC_011745.1 54623 55612 R catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate); 4-hydroxythreonine-4-phosphate dehydrogenase complement(54623..55612) Escherichia coli ED1a 7142522 YP_002396143.1 CDS surA NC_011745.1 55612 56898 R Chaperone involved in the folding of extracytoplasmic proteins, especially OmpA, OmpF and LamB; peptidyl-prolyl cis-trans isomerase SurA complement(55612..56898) Escherichia coli ED1a 7144052 YP_002396144.1 CDS imp NC_011745.1 56951 59305 R determines N-hexane tolerance and is involved in outer membrane permeability; organic solvent tolerance protein complement(56951..59305) Escherichia coli ED1a 7141500 YP_002396145.1 CDS djlA NC_011745.1 59560 60375 D functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system; Dna-J like membrane chaperone protein 59560..60375 Escherichia coli ED1a 7141107 YP_002396146.1 CDS rluA NC_011745.1 60493 61152 R catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs; 23S rRNA/tRNA pseudouridine synthase A complement(60493..61152) Escherichia coli ED1a 7140493 YP_002396147.1 CDS hepA NC_011745.1 61164 64070 R transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA; ATP-dependent helicase HepA complement(61164..64070) Escherichia coli ED1a 7141424 YP_002396148.1 CDS polB NC_011745.1 64234 66585 R Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C; DNA polymerase II complement(64234..66585) Escherichia coli ED1a 7139877 YP_002396149.1 CDS araD NC_011745.1 66660 67355 R catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase complement(66660..67355) Escherichia coli ED1a 7139082 YP_002396150.1 CDS araA NC_011745.1 67640 69142 R catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism; L-arabinose isomerase complement(67640..69142) Escherichia coli ED1a 7142599 YP_002396151.1 CDS araB NC_011745.1 69153 70853 R catalyzes the phosphorylation of ribulose to ribulose 5-phosphate; ribulokinase complement(69153..70853) Escherichia coli ED1a 7142596 YP_002396152.1 CDS araC NC_011745.1 71141 72037 D positive and negative regulator; regulates the araBAD and araFGH operons and other genes involved in the transport and catabolism of L-arabinose; DNA-binding transcriptional regulator AraC 71141..72037 Escherichia coli ED1a 7142597 YP_002396153.1 CDS ECED1_0064 NC_011745.1 72549 73400 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 72549..73400 Escherichia coli ED1a 7142598 YP_002396154.1 CDS ECED1_0065 NC_011745.1 73407 73829 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 73407..73829 Escherichia coli ED1a 7142835 YP_002396155.1 CDS yabI NC_011745.1 73984 74748 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 73984..74748 Escherichia coli ED1a 7142836 YP_002396156.1 CDS thiQ NC_011745.1 74862 75560 R with TbpA and ThiP is part of the thiamine and TPP transport system; thiamine transporter ATP-binding subunit complement(74862..75560) Escherichia coli ED1a 7143360 YP_002396157.1 CDS thiP NC_011745.1 75544 77154 R permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine; thiamine transporter membrane protein complement(75544..77154) Escherichia coli ED1a 7141549 YP_002396158.1 CDS tbpA NC_011745.1 77130 78113 R part of the thiamine and TPP transport system tbpA-thiPQ; thiamine transporter substrate binding subunit complement(77130..78113) Escherichia coli ED1a 7141548 YP_002396159.1 CDS sgrR NC_011745.1 78277 79932 R activates sgrS under glucose-phosphate stress conditions; transcriptional regulator SgrR complement(78277..79932) Escherichia coli ED1a 7140752 YP_002396160.1 CDS leuD NC_011745.1 80260 80865 R catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit complement(80260..80865) Escherichia coli ED1a 7143793 YP_002396161.1 CDS leuC NC_011745.1 80876 82276 R dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit complement(80876..82276) Escherichia coli ED1a 7141878 YP_002396162.1 CDS leuB NC_011745.1 82279 83370 R catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase complement(82279..83370) Escherichia coli ED1a 7141877 YP_002396163.1 CDS leuA NC_011745.1 83370 84941 R catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis; 2-isopropylmalate synthase complement(83370..84941) Escherichia coli ED1a 7141876 YP_002396164.1 CDS leuL NC_011745.1 85034 85120 R involved in attenuation control of the leuABCD operon in leucine biosynthesis; leu operon leader peptide complement(85034..85120) Escherichia coli ED1a 7141875 YP_002396165.1 CDS insA NC_011745.1 86446 86721 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 86446..86721 Escherichia coli ED1a 7141880 YP_002396166.1 CDS insB NC_011745.1 86640 87143 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 86640..87143 Escherichia coli ED1a 7141112 YP_002396167.1 CDS ilvI NC_011745.1 87817 89541 D catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; acetolactate synthase 3 catalytic subunit 87817..89541 Escherichia coli ED1a 7141881 YP_002396168.1 CDS ilvH NC_011745.1 89544 90035 D with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 89544..90035 Escherichia coli ED1a 7140242 YP_002396169.1 CDS fruR NC_011745.1 90215 91219 D binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism; DNA-binding transcriptional regulator FruR 90215..91219 Escherichia coli ED1a 7140241 YP_002396170.1 CDS mraZ NC_011745.1 91821 92279 D MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 91821..92279 Escherichia coli ED1a 7142180 YP_002396171.1 CDS mraW NC_011745.1 92281 93222 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20042184, 10493123, 2187182, 6350821; Product type e : enzyme; S-adenosyl-methyltransferase MraW 92281..93222 Escherichia coli ED1a 7139021 YP_002396172.1 CDS ftsL NC_011745.1 93219 93584 D membrane bound cell division protein at septum containing leucine zipper motif; cell division protein FtsL 93219..93584 Escherichia coli ED1a 7139019 YP_002396173.1 CDS ftsI NC_011745.1 93600 95366 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91072213, 92202178, 94095121, 9603865, 9614966, 1332942, 1447153, 2198024, 2677607, 2681146, 3049550, 3911028, 6350821; Product type e : enzyme; transpeptidase involved in septal peptidoglycan synthesis (penicillin-binding protein 3) 93600..95366 Escherichia coli ED1a 7143117 YP_002396174.1 CDS murE NC_011745.1 95353 96840 D involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 95353..96840 Escherichia coli ED1a 7142192 YP_002396175.1 CDS murF NC_011745.1 96837 98195 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88273095, 90248455, 91310568, 97128642, 11090285, 2668880, 9166795; Product type e : enzyme; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase 96837..98195 Escherichia coli ED1a 7139049 YP_002396176.1 CDS mraY NC_011745.1 98189 99271 D First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 98189..99271 Escherichia coli ED1a 7139050 YP_002396177.1 CDS murD NC_011745.1 99274 100590 D UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 99274..100590 Escherichia coli ED1a 7139020 YP_002396178.1 CDS ftsW NC_011745.1 100590 101834 D integral membrane protein involved in stabilizing FstZ ring during cell division; cell division protein FtsW 100590..101834 Escherichia coli ED1a 7139048 YP_002396179.1 CDS murG NC_011745.1 101831 102898 D UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 101831..102898 Escherichia coli ED1a 7143120 YP_002396180.1 CDS murC NC_011745.1 102952 104427 D Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 102952..104427 Escherichia coli ED1a 7139051 YP_002396181.1 CDS ddl NC_011745.1 104420 105340 D D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanine--D-alanine ligase 104420..105340 Escherichia coli ED1a 7139047 YP_002396182.1 CDS ftsQ NC_011745.1 105342 106172 D involved in septum formation; cell division protein FtsQ 105342..106172 Escherichia coli ED1a 7143081 YP_002396183.1 CDS ftsA NC_011745.1 106169 107431 D ATP-binding involved in recruitment of FtsK to Z ring; essential cell division protein; colocalizes with FtsZ through direct interaction to the septal ring structure; structurally similar to eukaryotic actin; binds directly to the cell membrane; cell division protein FtsA 106169..107431 Escherichia coli ED1a 7143119 YP_002396184.1 CDS ftsZ NC_011745.1 107492 108643 D GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 107492..108643 Escherichia coli ED1a 7142188 YP_002396185.1 CDS lpxC NC_011745.1 108744 109661 D zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 108744..109661 Escherichia coli ED1a 7143123 YP_002396186.1 CDS secM NC_011745.1 109892 110404 D secM translational pause allows for the initiation of secA translation; SecA regulator SecM 109892..110404 Escherichia coli ED1a 7141919 YP_002396187.1 CDS secA NC_011745.1 110466 113171 D functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 110466..113171 Escherichia coli ED1a 7141391 YP_002396188.1 CDS mutT NC_011745.1 113231 113629 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10218109, 89264540, 90136514, 91225007, 97444511, 1309939, 2841285, 3033442, 3288626, 7578113, 9063868; Product type e : enzyme; nucleoside triphosphate pyrophosphohydrolase 113231..113629 Escherichia coli ED1a 7141385 YP_002396189.1 CDS yacF NC_011745.1 114040 114783 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(114040..114783) Escherichia coli ED1a 7139058 YP_002396190.1 CDS coaE NC_011745.1 114783 115403 R catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase complement(114783..115403) Escherichia coli ED1a 7143362 YP_002396191.1 CDS guaC NC_011745.1 115628 116671 D catalyzes the NADPH-dependent deamination of GMP to inosine monophosphate; guanosine 5'-monophosphate oxidoreductase 115628..116671 Escherichia coli ED1a 7142031 YP_002396192.1 CDS hofC NC_011745.1 116706 117908 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96099298, 2904262, 7959070; Product type s : structure; type IV pilin biogenesis protein complement(116706..117908) Escherichia coli ED1a 7139845 YP_002396193.1 CDS hofB NC_011745.1 117898 119283 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96099298, 7959070; Product type pt : putative transporter; hypothetical protein complement(117898..119283) Escherichia coli ED1a 7139907 YP_002396194.1 CDS ppdD NC_011745.1 119293 119733 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20100782, 20271862, 96099298, 7959070; Product type ps : putative structure; putative major pilin subunit complement(119293..119733) Escherichia coli ED1a 7139906 YP_002396195.1 CDS nadC NC_011745.1 119937 120830 R catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; quinolinate phosphoribosyltransferase complement(119937..120830) Escherichia coli ED1a 7139100 YP_002396196.1 CDS ampD NC_011745.1 120918 121469 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90113890, 95047240, 2607970, 7959070; Product type e : enzyme; N-acetyl-anhydromuranmyl-L-alanine amidase 120918..121469 Escherichia coli ED1a 7140332 YP_002396197.1 CDS ampE NC_011745.1 121466 122320 D involved in regulation of beta-lactamase; putative signaling protein; regulatory protein AmpE 121466..122320 Escherichia coli ED1a 7143707 YP_002396198.1 CDS aroP NC_011745.1 122363 123733 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1104763, 90174991, 9150230; Product type t : transporter; aromatic amino acid transporter complement(122363..123733) Escherichia coli ED1a 7143708 YP_002396199.1 CDS ECED1_0111 NC_011745.1 124261 126042 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10702359; hypothetical protein 124261..126042 Escherichia coli ED1a 7142634 YP_002396200.1 CDS ECED1_0112 NC_011745.1 126045 126329 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative Colicin E7 immunity protein 126045..126329 Escherichia coli ED1a 7142837 YP_002396201.1 CDS ECED1_0114 NC_011745.1 126737 127027 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative Colicin E7 immunity protein 126737..127027 Escherichia coli ED1a 7142839 YP_002396202.1 CDS ECED1_0116 NC_011745.1 127430 127726 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative Colicin E7 immunity protein 127430..127726 Escherichia coli ED1a 7142841 YP_002396203.1 CDS pdhR NC_011745.1 128182 128946 D activates lctPRD operon; autoregulates itself through repression of pdhR-aceEF-lpdA operon; regulates pyruvate dehydrogenase complex; transcriptional regulator PdhR 128182..128946 Escherichia coli ED1a 7142842 YP_002396204.1 CDS aceE NC_011745.1 129107 131770 D E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 129107..131770 Escherichia coli ED1a 7140759 YP_002396205.1 CDS aceF NC_011745.1 131785 133677 D E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains; dihydrolipoamide acetyltransferase 131785..133677 Escherichia coli ED1a 7143638 YP_002396206.1 CDS lpd NC_011745.1 133885 135309 D E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 133885..135309 Escherichia coli ED1a 7143639 YP_002396207.1 CDS yacH NC_011745.1 135551 137308 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(135551..137308) Escherichia coli ED1a 7141908 YP_002396208.1 CDS acnB NC_011745.1 137663 140260 D catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate; bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase 137663..140260 Escherichia coli ED1a 7143363 YP_002396209.1 CDS yacL NC_011745.1 140435 140797 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2666401, 7567469; hypothetical protein 140435..140797 Escherichia coli ED1a 7143644 YP_002396210.1 CDS speD NC_011745.1 140835 141629 R S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine; S-adenosylmethionine decarboxylase complement(140835..141629) Escherichia coli ED1a 7143364 YP_002396211.1 CDS speE NC_011745.1 141645 142511 R catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase complement(141645..142511) Escherichia coli ED1a 7143826 YP_002396212.1 CDS yacC NC_011745.1 142617 143135 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2666401; hypothetical protein complement(142617..143135) Escherichia coli ED1a 7143827 YP_002396213.1 CDS cueO NC_011745.1 143130 144680 D laccase; copper-stimulated phenoloxidase and ferroxidase which may be involved in copper detoxification; multicopper oxidase 143130..144680 Escherichia coli ED1a 7143361 YP_002396214.1 CDS gcd NC_011745.1 144727 147117 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10359647, 11604400, 14612441, 91035240, 93123180, 93286127; Product type e : enzyme; glucose dehydrogenase complement(144727..147117) Escherichia coli ED1a 7142081 YP_002396215.1 CDS hpt NC_011745.1 147323 147859 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 13808016, 339828, 6787390, 6801015, 12070315; Product type e : enzyme; hypoxanthine phosphoribosyltransferase 147323..147859 Escherichia coli ED1a 7143164 YP_002396216.1 CDS can NC_011745.1 147900 148562 R catalyzes the interconversion of bicarbonate and carbon dioxide; carbonic anhydrase complement(147900..148562) Escherichia coli ED1a 7139915 YP_002396217.1 CDS yadG NC_011745.1 148671 149597 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATP-binding protein 148671..149597 Escherichia coli ED1a 7139305 YP_002396218.1 CDS yadH NC_011745.1 149594 150364 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10474187; Product type pt : putative transporter; putative ABC transporter membrane protein 149594..150364 Escherichia coli ED1a 7143368 YP_002396219.1 CDS yadI NC_011745.1 150469 150909 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative PTS Enzyme IIA 150469..150909 Escherichia coli ED1a 7143369 YP_002396220.1 CDS yadE NC_011745.1 150973 152202 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative exported polysaccharide deacetylase 150973..152202 Escherichia coli ED1a 7143370 YP_002396221.1 CDS panD NC_011745.1 152206 152586 R Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase complement(152206..152586) Escherichia coli ED1a 7143367 YP_002396222.1 CDS yadD NC_011745.1 152860 153840 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11319082; Product type pe : putative enzyme; putative transposase 152860..153840 Escherichia coli ED1a 7144041 YP_002396223.1 CDS panC NC_011745.1 153922 154773 R catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase complement(153922..154773) Escherichia coli ED1a 7143366 YP_002396224.1 CDS panB NC_011745.1 154785 155579 R catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase complement(154785..155579) Escherichia coli ED1a 7144040 YP_002396225.1 CDS ECED1_0141 NC_011745.1 157002 157598 R Evidence 2b : Function of strongly homologous gene; Product type ps : putative structure; protein yadK, putative fimbrial-like adhesin complement(157002..157598) Escherichia coli ED1a 7142843 YP_002396226.1 CDS ECED1_0142 NC_011745.1 157625 158239 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin protein YadL complement(157625..158239) Escherichia coli ED1a 7142844 YP_002396227.1 CDS ECED1_0143 NC_011745.1 158245 158811 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin protein YadM complement(158245..158811) Escherichia coli ED1a 7142845 YP_002396228.1 CDS htrE NC_011745.1 158828 161416 R similar to the fimbrial usher protein PapC; putative outer membrane usher protein complement(158828..161416) Escherichia coli ED1a 7142846 YP_002396229.1 CDS ecpD NC_011745.1 161451 162191 R Evidence 2b : Function of strongly homologous gene; PubMedId : 93352405, 8102362, 15561151; Product type f : factor; putative chaperone protein EcpD complement(161451..162191) Escherichia coli ED1a 7140175 YP_002396230.1 CDS yadN NC_011745.1 162300 162914 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin exported protein complement(162300..162914) Escherichia coli ED1a 7139771 YP_002396231.1 CDS folK NC_011745.1 163254 163733 R catalyzes the formation of 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine and ATP; 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase complement(163254..163733) Escherichia coli ED1a 7143371 YP_002396232.1 CDS pcnB NC_011745.1 163730 165148 R Polymerase that creates the 3' poly(A) tail found in some mRNA's; poly(A) polymerase I complement(163730..165148) Escherichia coli ED1a 7142160 YP_002396233.1 CDS yadB NC_011745.1 165187 166113 R this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu; glutamyl-Q tRNA(Asp) synthetase complement(165187..166113) Escherichia coli ED1a 7144050 YP_002396234.1 CDS dksA NC_011745.1 166150 166605 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15294157, 90202727, 2013578, 9298646, 9600841; Product type r : regulator; RNA polymerase-binding transcription factor complement(166150..166605) Escherichia coli ED1a 7143365 YP_002396235.1 CDS sfsA NC_011745.1 166783 167487 R Regulatory factor involved in maltose metabolism; sugar fermentation stimulation protein A complement(166783..167487) Escherichia coli ED1a 7140496 YP_002396236.1 CDS ligT NC_011745.1 167502 168032 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 97094878; Product type e : enzyme; 2'-5' RNA ligase complement(167502..168032) Escherichia coli ED1a 7141404 YP_002396237.1 CDS hrpB NC_011745.1 168106 170535 D similar in sequence to the ATP-dependent RNA helicase HrpA; ATP-dependent RNA helicase HrpB 168106..170535 Escherichia coli ED1a 7141887 YP_002396238.1 CDS mrcB NC_011745.1 170629 173163 D bifunctional periplasmic enzyme; contains transglycosylase and transpeptidase activity; major enzyme for peptidoglycan biosynthesis in Escherichia coli; transmembrane protein; forms dimers; three variants, one of which may be a degradation product, while the other appears to result from an alternative initiation site, are found within the cell; penicillin-binding protein 1b 170629..173163 Escherichia coli ED1a 7139917 YP_002396239.1 CDS fhuA NC_011745.1 173383 175641 D involved with the transport of ferrichrome across the outer membrane; binds the ferrichrome-iron ligand and interacts with the TonB protein; ferrichrome outer membrane transporter 173383..175641 Escherichia coli ED1a 7139023 YP_002396240.1 CDS fhuC NC_011745.1 175692 176489 D part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; iron-hydroxamate transporter ATP-binding subunit 175692..176489 Escherichia coli ED1a 7144169 YP_002396241.1 CDS fhuD NC_011745.1 176489 177379 D Part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; binds to all hydroxamate siderophores; iron-hydroxamate transporter substrate-binding subunit 176489..177379 Escherichia coli ED1a 7144171 YP_002396242.1 CDS fhuB NC_011745.1 177376 179358 D part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome; iron-hydroxamate transporter permease subunit 177376..179358 Escherichia coli ED1a 7144172 YP_002396243.1 CDS hemL NC_011745.1 179393 180673 R Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase complement(179393..180673) Escherichia coli ED1a 7144170 YP_002396244.1 CDS clcA NC_011745.1 180898 182319 D Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation; chloride channel protein 180898..182319 Escherichia coli ED1a 7139873 YP_002396245.1 CDS yadR NC_011745.1 182401 182745 D essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors; iron-sulfur cluster insertion protein ErpA 182401..182745 Escherichia coli ED1a 7139368 YP_002396246.1 CDS yadS NC_011745.1 182792 183415 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(182792..183415) Escherichia coli ED1a 7143372 YP_002396247.1 CDS btuF NC_011745.1 183453 184253 R solute binding component of the vitamin B12 transport system BtuCDF; vitamin B12-transporter protein BtuF complement(183453..184253) Escherichia coli ED1a 7143373 YP_002396248.1 CDS pfs NC_011745.1 184246 184944 R enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase complement(184246..184944) Escherichia coli ED1a 7140468 YP_002396249.1 CDS dgt NC_011745.1 185028 186545 D forms a homotetramer; requires magnesium for activity; catalyzes the hydrolysis of dGTP to form deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase 185028..186545 Escherichia coli ED1a 7144073 YP_002396250.1 CDS degP NC_011745.1 186675 188099 D protease Do; required at high temperature; degrades damaged proteins; serine endoprotease 186675..188099 Escherichia coli ED1a 7143109 YP_002396251.1 CDS cdaR NC_011745.1 188254 189411 D regulates the expression of the operons for the enzymes involved in galactarate, glucarate and glycerate utilization; carbohydrate diacid transcriptional activator CdaR 188254..189411 Escherichia coli ED1a 7143086 YP_002396252.1 CDS yaeH NC_011745.1 189465 189851 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(189465..189851) Escherichia coli ED1a 7139323 YP_002396253.1 CDS dapD NC_011745.1 190163 190987 R catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase complement(190163..190987) Escherichia coli ED1a 7143376 YP_002396254.1 CDS glnD NC_011745.1 191018 193690 R catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein; PII uridylyl-transferase complement(191018..193690) Escherichia coli ED1a 7143064 YP_002396255.1 CDS map NC_011745.1 193752 194546 R catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase complement(193752..194546) Escherichia coli ED1a 7142954 YP_002396256.1 CDS rpsB NC_011745.1 194914 195639 D one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 194914..195639 Escherichia coli ED1a 7140762 YP_002396257.1 CDS tsf NC_011745.1 195774 196625 D EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 195774..196625 Escherichia coli ED1a 7140085 YP_002396258.1 CDS pyrH NC_011745.1 196772 197497 D Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 196772..197497 Escherichia coli ED1a 7140834 YP_002396259.1 CDS frr NC_011745.1 197647 198204 D Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 197647..198204 Escherichia coli ED1a 7141237 YP_002396260.1 CDS dxr NC_011745.1 198296 199492 D catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 198296..199492 Escherichia coli ED1a 7142175 YP_002396261.1 CDS ispU NC_011745.1 199678 200439 D catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 199678..200439 Escherichia coli ED1a 7139758 YP_002396262.1 CDS cdsA NC_011745.1 200452 201309 D catalyzes the synthesis of CDP-diglyceride from CTP and phosphatidate; CDP-diglyceride synthase 200452..201309 Escherichia coli ED1a 7142469 YP_002396263.1 CDS yaeL NC_011745.1 201321 202673 D catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response; zinc metallopeptidase RseP 201321..202673 Escherichia coli ED1a 7139326 YP_002396264.1 CDS yaeT NC_011745.1 202703 205135 D part of a complex with YfgL, YfiO, and NlpB involved in outer membrane protein biosynthesis; involved in the assembly of outer membrane proteins; outer membrane protein assembly factor YaeT 202703..205135 Escherichia coli ED1a 7143378 YP_002396265.1 CDS hlpA NC_011745.1 205257 205742 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15101556, 90201355, 97032152, 99386928, 1987124, 2843433, 9298646, 2167239; Product type f : factor; periplasmic chaperone 205257..205742 Escherichia coli ED1a 7143382 YP_002396266.1 CDS lpxD NC_011745.1 205746 206771 D adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 205746..206771 Escherichia coli ED1a 7139901 YP_002396267.1 CDS fabZ NC_011745.1 206876 207331 D in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 206876..207331 Escherichia coli ED1a 7141920 YP_002396268.1 CDS lpxA NC_011745.1 207335 208123 D catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 207335..208123 Escherichia coli ED1a 7144123 YP_002396269.1 CDS lpxB NC_011745.1 208123 209271 D catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; lipid-A-disaccharide synthase 208123..209271 Escherichia coli ED1a 7141917 YP_002396270.1 CDS rnhB NC_011745.1 209268 209864 D RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 209268..209864 Escherichia coli ED1a 7141918 YP_002396271.1 CDS dnaE NC_011745.1 209901 213383 D catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 209901..213383 Escherichia coli ED1a 7141438 YP_002396272.1 CDS accA NC_011745.1 213396 214355 D catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 213396..214355 Escherichia coli ED1a 7140505 YP_002396273.1 CDS ldcC NC_011745.1 214453 216594 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 97480927, 98195734, 98357244, 9226257, 9723924; Product type e : enzyme; lysine decarboxylase 2 214453..216594 Escherichia coli ED1a 7143632 YP_002396274.1 CDS yaeR NC_011745.1 216651 217040 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 216651..217040 Escherichia coli ED1a 7141870 YP_002396275.1 CDS tilS NC_011745.1 217105 218418 D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU; ATP-dependent; responsible for modifying the wobble-base of the CAU anticodon of tRNAIle such that it exhibits proper recognition of the AUA codon rather than the AUG codon and is in turn properly recognized by isoleucyl-tRNA synthetase; tRNA(Ile)-lysidine synthetase 217105..218418 Escherichia coli ED1a 7143381 YP_002396276.1 CDS rof NC_011745.1 218452 218706 R Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination; Rho-binding antiterminator complement(218452..218706) Escherichia coli ED1a 7141558 YP_002396277.1 CDS yaeP NC_011745.1 218699 218899 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(218699..218899) Escherichia coli ED1a 7141445 YP_002396278.1 CDS yaeQ NC_011745.1 219065 219610 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 219065..219610 Escherichia coli ED1a 7143379 YP_002396279.1 CDS yaeJ NC_011745.1 219607 220029 D Evidence 4 : Homologs of previously reported genes of unknown function; peptidyl-tRNA hydrolase domain-containing protein 219607..220029 Escherichia coli ED1a 7143380 YP_002396280.1 CDS nlpE NC_011745.1 220043 220753 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11830644, 95362641, 95362642; Product type lp : lipoprotein; lipoprotein involved with copper homeostasis and adhesion 220043..220753 Escherichia coli ED1a 7143377 YP_002396281.1 CDS yaeF NC_011745.1 220909 221733 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein complement(220909..221733) Escherichia coli ED1a 7140401 YP_002396282.1 CDS proS NC_011745.1 221786 223504 R catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase complement(221786..223504) Escherichia coli ED1a 7143375 YP_002396283.1 CDS yaeB NC_011745.1 223615 224322 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(223615..224322) Escherichia coli ED1a 7139132 YP_002396284.1 CDS rcsF NC_011745.1 224319 224723 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 93094132; Product type pr : putative regulator; outer membrane lipoprotein complement(224319..224723) Escherichia coli ED1a 7143374 YP_002396285.1 CDS metQ NC_011745.1 224841 225656 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12169620, 12218041, 12819857, 1459951; Product type t : transporter; DL-methionine transporter substrate-binding subunit complement(224841..225656) Escherichia coli ED1a 7141571 YP_002396286.1 CDS metI NC_011745.1 225696 226349 R part of the MetNIQ methionine uptake system; DL-methionine transporter permease subunit complement(225696..226349) Escherichia coli ED1a 7142261 YP_002396287.1 CDS metN NC_011745.1 226342 227373 R part of the metNIQ transport system for methionine; DL-methionine transporter ATP-binding subunit complement(226342..227373) Escherichia coli ED1a 7142255 YP_002396288.1 CDS gmhB NC_011745.1 227561 228133 D Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate; D,D-heptose 1,7-bisphosphate phosphatase 227561..228133 Escherichia coli ED1a 7142260 YP_002396289.1 CDS dkgB NC_011745.1 233893 234696 D catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; 2,5-diketo-D-gluconate reductase B 233893..234696 Escherichia coli ED1a 7140572 YP_002396290.1 CDS yafC NC_011745.1 234693 235607 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(234693..235607) Escherichia coli ED1a 7140495 YP_002396291.1 CDS yafD NC_011745.1 235848 236648 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1663890; hypothetical protein 235848..236648 Escherichia coli ED1a 7143383 YP_002396292.1 CDS yafE NC_011745.1 236726 237496 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative S-adenosyl-L-methionine-dependent methyltransferase 236726..237496 Escherichia coli ED1a 7143384 YP_002396293.1 CDS mltD NC_011745.1 237543 238901 R catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; may play a role in recycling muropeptides during cell division and/or cell elongation; in Helicobacter pylori MltD is a endolytic transglycosylase involved mainly in the rearrangement of the peptidoglycan layer of the bacterial cell wall; membrane-bound lytic murein transglycosylase D complement(237543..238901) Escherichia coli ED1a 7143385 YP_002396294.1 CDS gloB NC_011745.1 238973 239728 R catalyzes the hydrolysis of S-D-lactoylglutathione to D-lactic acid and reduced glutathione; plays an important role in cellular detoxification using glutathione; hydroxyacylglutathione hydrolase complement(238973..239728) Escherichia coli ED1a 7138993 YP_002396295.1 CDS yafS NC_011745.1 239762 240484 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative S-adenosyl-L-methionine-dependent methyltransferase 239762..240484 Escherichia coli ED1a 7142965 YP_002396296.1 CDS rnhA NC_011745.1 240481 240948 R An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease H complement(240481..240948) Escherichia coli ED1a 7143394 YP_002396297.1 CDS dnaQ NC_011745.1 241013 241744 D 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 241013..241744 Escherichia coli ED1a 7141437 YP_002396298.1 CDS yafT NC_011745.1 242282 243067 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative aminopeptidase 242282..243067 Escherichia coli ED1a 7140583 YP_002396299.1 CDS ECED1_0222 NC_011745.1 243407 243907 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(243407..243907) Escherichia coli ED1a 7143395 YP_002396300.1 CDS ECED1_0227 NC_011745.1 245272 248799 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein complement(245272..248799) Escherichia coli ED1a 7142850 YP_002396301.1 CDS ECED1_0228 NC_011745.1 248819 250327 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(248819..250327) Escherichia coli ED1a 7142851 YP_002396302.1 CDS ECED1_0229 NC_011745.1 250266 251009 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(250266..251009) Escherichia coli ED1a 7142852 YP_002396303.1 CDS ECED1_0230 NC_011745.1 251006 253768 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative ATP-dependent Clp proteinase Aec27 ATP-binding chain, with chaperone activity complement(251006..253768) Escherichia coli ED1a 7142853 YP_002396304.1 CDS ECED1_0231 NC_011745.1 253778 254542 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein complement(253778..254542) Escherichia coli ED1a 7142854 YP_002396305.1 CDS ECED1_0232 NC_011745.1 254547 255893 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(254547..255893) Escherichia coli ED1a 7142855 YP_002396306.1 CDS ECED1_0233 NC_011745.1 255896 256420 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(255896..256420) Escherichia coli ED1a 7142856 YP_002396307.1 CDS ECED1_0234 NC_011745.1 256417 257709 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(256417..257709) Escherichia coli ED1a 7142857 YP_002396308.1 CDS ECED1_0235 NC_011745.1 257714 258763 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(257714..258763) Escherichia coli ED1a 7142858 YP_002396309.1 CDS ECED1_0236 NC_011745.1 258727 260586 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(258727..260586) Escherichia coli ED1a 7142859 YP_002396310.1 CDS ECED1_0237 NC_011745.1 260574 260999 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(260574..260999) Escherichia coli ED1a 7142860 YP_002396311.1 CDS ECED1_0238 NC_011745.1 261004 262488 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(261004..262488) Escherichia coli ED1a 7142861 YP_002396312.1 CDS ECED1_0239 NC_011745.1 262511 263065 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(262511..263065) Escherichia coli ED1a 7142862 YP_002396313.1 CDS ECED1_0240 NC_011745.1 263724 264242 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 263724..264242 Escherichia coli ED1a 7142863 YP_002396314.1 CDS ECED1_0241 NC_011745.1 264463 266694 D Evidence 4 : Homologs of previously reported genes of unknown function; putative VgrG/E protein associated with Rhs elements 264463..266694 Escherichia coli ED1a 7142864 YP_002396315.1 CDS ECED1_0242 NC_011745.1 266707 267483 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 266707..267483 Escherichia coli ED1a 7142865 YP_002396316.1 CDS ECED1_0243 NC_011745.1 267712 267909 R Evidence 6 : Doubtful CDS; hypothetical protein complement(267712..267909) Escherichia coli ED1a 7142866 YP_002396317.1 CDS ECED1_0244 NC_011745.1 267911 268174 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 267911..268174 Escherichia coli ED1a 7142867 YP_002396318.1 CDS ECED1_0245 NC_011745.1 268144 268464 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 268144..268464 Escherichia coli ED1a 7142868 YP_002396319.1 CDS ECED1_0246 NC_011745.1 268449 269003 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 268449..269003 Escherichia coli ED1a 7142869 YP_002396320.1 CDS ECED1_0247 NC_011745.1 268988 269530 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 268988..269530 Escherichia coli ED1a 7142870 YP_002396321.1 CDS ECED1_0248 NC_011745.1 269515 271191 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 269515..271191 Escherichia coli ED1a 7142871 YP_002396322.1 CDS ECED1_0249 NC_011745.1 271467 271646 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative H-repeat associated protein 271467..271646 Escherichia coli ED1a 7141788 YP_002396323.1 CDS ECED1_0250 NC_011745.1 271746 272147 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transposase 271746..272147 Escherichia coli ED1a 7141789 YP_002396324.1 CDS ECED1_0251 NC_011745.1 272460 272963 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 272460..272963 Escherichia coli ED1a 7141790 YP_002396325.1 CDS ECED1_0252 NC_011745.1 273033 273545 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 273033..273545 Escherichia coli ED1a 7141791 YP_002396326.1 CDS yafV NC_011745.1 273816 274586 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8526497; Product type pe : putative enzyme; hypothetical protein complement(273816..274586) Escherichia coli ED1a 7141792 YP_002396327.1 CDS ivy NC_011745.1 274740 275213 D inactivates vertebrate C-type lysozyme; C-lysozyme inhibitor 274740..275213 Escherichia coli ED1a 7143396 YP_002396328.1 CDS fadE NC_011745.1 275256 277700 R functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA; acyl-CoA dehydrogenase complement(275256..277700) Escherichia coli ED1a 7142477 YP_002396329.1 CDS gmhA NC_011745.1 277940 278518 D catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate; phosphoheptose isomerase 277940..278518 Escherichia coli ED1a 7144127 YP_002396330.1 CDS yafJ NC_011745.1 278723 279490 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glutamine amidotransferases class-II 278723..279490 Escherichia coli ED1a 7141907 YP_002396331.1 CDS yafK NC_011745.1 279461 280201 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(279461..280201) Escherichia coli ED1a 7143386 YP_002396332.1 CDS yafL NC_011745.1 280504 281262 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative exported hydrolase 280504..281262 Escherichia coli ED1a 7143387 YP_002396333.1 CDS fhiA NC_011745.1 282354 284093 R Evidence 7 : Gene remnant; Product type s : structure; flagellar system protein complement(282354..284093) Escherichia coli ED1a 7143390 YP_002396334.1 CDS mbhA NC_011745.1 283933 284823 D Evidence 2b : Function of strongly homologous gene; PubMedId : 15687208; Product type s : structure; hypothetical protein 283933..284823 Escherichia coli ED1a 7144167 YP_002396335.1 CDS dinB NC_011745.1 284894 285949 D involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 284894..285949 Escherichia coli ED1a 7142217 YP_002396336.1 CDS yafN NC_011745.1 286001 286294 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12813093, 14594833; Product type pf : putative factor; putative antitoxin of the YafO-YafN toxin-antitoxin system 286001..286294 Escherichia coli ED1a 7142030 YP_002396337.1 CDS yafO NC_011745.1 286297 286695 D YafO overproduction induces toxicity; it is believed to be the toxin of a toxin-antitoxin pair; unknown function; putative toxin YafO 286297..286695 Escherichia coli ED1a 7143391 YP_002396338.1 CDS yafP NC_011745.1 286705 287157 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12813093; Product type pe : putative enzyme; hypothetical protein 286705..287157 Escherichia coli ED1a 7143392 YP_002396339.1 CDS ECED1_0269 NC_011745.1 287335 288486 D mutations in this gene result in a compromised ability for drug-inducible mexXY expression; expression is inducible by the same ribosome-targeting agents that induce mexXY; hypothetical protein 287335..288486 Escherichia coli ED1a 7143393 YP_002396340.1 CDS prfH NC_011745.1 288597 289097 D similar to release factor 1 and 2; peptide chain release factor-like protein 288597..289097 Escherichia coli ED1a 7141793 YP_002396341.1 CDS pepD NC_011745.1 289154 290611 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1695895, 21101837, 88121730, 92204123, 2651887; Product type e : enzyme; aminoacyl-histidine dipeptidase (peptidase D) complement(289154..290611) Escherichia coli ED1a 7139118 YP_002396342.1 CDS gpt NC_011745.1 290872 291330 D catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively; xanthine-guanine phosphoribosyltransferase 290872..291330 Escherichia coli ED1a 7144060 YP_002396343.1 CDS frsA NC_011745.1 291422 292666 D forms a 1:1 complex with the unphosphorylated from of enzyme IIAGlc; FrsA may promote fermentation; fermentation/respiration switch protein 291422..292666 Escherichia coli ED1a 7143016 YP_002396344.1 CDS crl NC_011745.1 292724 293125 D involved in the expression of csgBA which is involved in curli formation; interacts with sigmaS; DNA-binding transcriptional regulator Crl 292724..293125 Escherichia coli ED1a 7142176 YP_002396345.1 CDS phoE NC_011745.1 293164 294219 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89178658, 89380253, 92219258, 98090453, 1380671, 1848301, 1848682, 6089111, 6341601, 7679770; Product type t : transporter; outer membrane phosphoporin protein E complement(293164..294219) Escherichia coli ED1a 7142054 YP_002396346.1 CDS proB NC_011745.1 294508 295611 D catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 294508..295611 Escherichia coli ED1a 7144104 YP_002396347.1 CDS proA NC_011745.1 295623 296876 D Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 295623..296876 Escherichia coli ED1a 7139128 YP_002396348.1 CDS ECED1_0278 NC_011745.1 297377 298057 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 297377..298057 Escherichia coli ED1a 7140594 YP_002396349.1 CDS ECED1_0279 NC_011745.1 298059 299696 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(298059..299696) Escherichia coli ED1a 7141794 YP_002396350.1 CDS ECED1_0280 NC_011745.1 300366 300614 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative AlpA-family regulatory protein from prophage 300366..300614 Escherichia coli ED1a 7141795 YP_002396351.1 CDS ECED1_0284 NC_011745.1 303545 304108 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 303545..304108 Escherichia coli ED1a 7143752 YP_002396352.1 CDS ECED1_0285 NC_011745.1 304239 306629 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative helicase 304239..306629 Escherichia coli ED1a 7141797 YP_002396353.1 CDS ECED1_0286 NC_011745.1 306647 307027 R Evidence 6 : Doubtful CDS; hypothetical protein complement(306647..307027) Escherichia coli ED1a 7141798 YP_002396354.1 CDS ECED1_0287 NC_011745.1 306893 307204 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 306893..307204 Escherichia coli ED1a 7141799 YP_002396355.1 CDS ECED1_0288 NC_011745.1 307301 308278 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 307301..308278 Escherichia coli ED1a 7141800 YP_002396356.1 CDS ECED1_0293 NC_011745.1 310012 310845 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 310012..310845 Escherichia coli ED1a 7142952 YP_002396357.1 CDS ECED1_0294 NC_011745.1 311068 312057 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase, IS110 family 311068..312057 Escherichia coli ED1a 7141805 YP_002396358.1 CDS ECED1_0295 NC_011745.1 312033 312131 D Evidence 6 : Doubtful CDS; hypothetical protein 312033..312131 Escherichia coli ED1a 7141806 YP_002396359.1 CDS xylE NC_011745.1 312475 313968 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 2820984, 88007632, 91154204, 2836810, 3543693; Product type t : transporter; D-xylose-proton symporter complement(312475..313968) Escherichia coli ED1a 7141807 YP_002396360.1 CDS ECED1_0297 NC_011745.1 314379 315815 D Evidence 2b : Function of strongly homologous gene; Product type t : transporter; Sugar (And other) transporter 314379..315815 Escherichia coli ED1a 7139214 YP_002396361.1 CDS ECED1_0298 NC_011745.1 316227 316709 R Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase IS605 family, IS200 group complement(316227..316709) Escherichia coli ED1a 7141808 YP_002396362.1 CDS ECED1_0299 NC_011745.1 316850 317659 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(316850..317659) Escherichia coli ED1a 7141809 YP_002396363.1 CDS ECED1_0300 NC_011745.1 317684 319189 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1339433; Product type e : enzyme; Methylmalonate-semialdehyde dehydrogenase complement(317684..319189) Escherichia coli ED1a 7141810 YP_002396364.1 CDS ECED1_0301 NC_011745.1 319579 320448 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative AraC-type DNA-binding domain-containing protein 319579..320448 Escherichia coli ED1a 7141811 YP_002396365.1 CDS iolE NC_011745.1 321325 322245 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14993306; Product type e : enzyme; 2-keto-myo-inositol dehydratase 321325..322245 Escherichia coli ED1a 7141812 YP_002396366.1 CDS iolG NC_011745.1 322246 323274 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1761221, 112095; Product type e : enzyme; inositol 2-dehydrogenase 322246..323274 Escherichia coli ED1a 7142445 YP_002396367.1 CDS srfJ NC_011745.1 323372 324715 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10844662; Product type pe : putative enzyme; putative glucosylceramidase 323372..324715 Escherichia coli ED1a 7142446 YP_002396368.1 CDS ECED1_0306 NC_011745.1 324716 325549 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative myo-inositol catabolism protein (iolI-like) 324716..325549 Escherichia coli ED1a 7143839 YP_002396369.1 CDS ECED1_0307 NC_011745.1 325546 326712 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; major facilitator superfamily transporter complement(325546..326712) Escherichia coli ED1a 7141813 YP_002396370.1 CDS ECED1_0310 NC_011745.1 328106 328453 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1310503, 1321417; putative IS91 orf2 complement(328106..328453) Escherichia coli ED1a 7141816 YP_002396371.1 CDS ECED1_0311 NC_011745.1 328589 330526 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative carbohydrate kinase complement(328589..330526) Escherichia coli ED1a 7141817 YP_002396372.1 CDS ECED1_0314 NC_011745.1 330931 332880 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1577690, 11497462; Product type pe : putative enzyme; putative malonic semialdehyde oxidative decarboxylase (iolD-like) 330931..332880 Escherichia coli ED1a 7141818 YP_002396373.1 CDS ECED1_0315 NC_011745.1 333061 334083 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative myo-inositol 2-dehydrogenase (iolG-like) 333061..334083 Escherichia coli ED1a 7141819 YP_002396374.1 CDS ECED1_0316 NC_011745.1 334156 335382 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9099855; Product type pt : putative transporter; putative permeases of the major facilitator superfamily MFS 334156..335382 Escherichia coli ED1a 7141820 YP_002396375.1 CDS ECED1_0317 NC_011745.1 335519 335662 R Evidence 7 : Gene remnant; hypothetical protein complement(335519..335662) Escherichia coli ED1a 7141821 YP_002396376.1 CDS ECED1_0318 NC_011745.1 335652 336053 D Evidence 4 : Homologs of previously reported genes of unknown function; putative transposase, IS3 family 335652..336053 Escherichia coli ED1a 7141822 YP_002396377.1 CDS ECED1_0319 NC_011745.1 336050 336397 D Evidence 4 : Homologs of previously reported genes of unknown function; putative transposase ORF2, IS66 family 336050..336397 Escherichia coli ED1a 7141823 YP_002396378.1 CDS ECED1_0320 NC_011745.1 336447 337853 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transposase ORF 1, IS66 family 336447..337853 Escherichia coli ED1a 7141824 YP_002396379.1 CDS ECED1_0321 NC_011745.1 338061 338222 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 338061..338222 Escherichia coli ED1a 7141825 YP_002396380.1 CDS ECED1_0322 NC_011745.1 338315 339547 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative reverse transcriptase 338315..339547 Escherichia coli ED1a 7141826 YP_002396381.1 CDS ECED1_0323 NC_011745.1 339663 339809 D Evidence 7 : Gene remnant; hypothetical protein 339663..339809 Escherichia coli ED1a 7140766 YP_002396382.1 CDS deoM NC_011745.1 339839 340378 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15385522, 15075407; Product type e : enzyme; Deoxyribose specific mutarotase (partial) complement(339839..340378) Escherichia coli ED1a 7141828 YP_002396383.1 CDS deoP NC_011745.1 340390 341706 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 5385522, 15075407, 10648508; Product type pe : putative enzyme; putative L-fucose permease complement(340390..341706) Escherichia coli ED1a 7143094 YP_002396384.1 CDS deoK NC_011745.1 341734 342750 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10648508, 15385522; Product type e : enzyme; Deoxyribokinase complement(341734..342750) Escherichia coli ED1a 7143095 YP_002396385.1 CDS deoQ NC_011745.1 342954 343739 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15385522, 10648508; Product type pr : putative regulator; putative transcriptional regulator 342954..343739 Escherichia coli ED1a 7143093 YP_002396386.1 CDS ECED1_0328 NC_011745.1 343916 344089 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 343916..344089 Escherichia coli ED1a 7143096 YP_002396387.1 CDS rpmE2 NC_011745.1 345343 345606 D RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 type B 345343..345606 Escherichia coli ED1a 7141830 YP_002396388.1 CDS ykgK NC_011745.1 346782 347372 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 346782..347372 Escherichia coli ED1a 7140954 YP_002396389.1 CDS insA NC_011745.1 347496 347771 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 347496..347771 Escherichia coli ED1a 7140953 YP_002396390.1 CDS insB NC_011745.1 347690 348193 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 347690..348193 Escherichia coli ED1a 7141113 YP_002396391.1 CDS ecpA NC_011745.1 348223 348810 D Evidence 2b : Function of strongly homologous gene; PubMedId : 17563352, 11466275; Product type s : structure; common pilus ECP 348223..348810 Escherichia coli ED1a 7141136 YP_002396392.1 CDS yagY NC_011745.1 348867 349535 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 348867..349535 Escherichia coli ED1a 7139770 YP_002396393.1 CDS yagX NC_011745.1 349561 352086 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 349561..352086 Escherichia coli ED1a 7143399 YP_002396394.1 CDS ECED1_0339 NC_011745.1 353155 353931 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative reductase 353155..353931 Escherichia coli ED1a 7143397 YP_002396395.1 CDS ykgB NC_011745.1 354091 354684 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(354091..354684) Escherichia coli ED1a 7141831 YP_002396396.1 CDS ykgI NC_011745.1 354696 354932 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(354696..354932) Escherichia coli ED1a 7140944 YP_002396397.1 CDS ykgC NC_011745.1 355041 356366 R Involved in disulfide oxidoreductase activity and electron transport; pyridine nucleotide-disulfide oxidoreductase complement(355041..356366) Escherichia coli ED1a 7140952 YP_002396398.1 CDS ykgD NC_011745.1 356593 357447 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative AraC-type DNA-binding transcriptional regulator 356593..357447 Escherichia coli ED1a 7140945 YP_002396399.1 CDS ykgE NC_011745.1 357974 358693 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydroxyacid oxidoreductase (Fe-S centre) 357974..358693 Escherichia coli ED1a 7140946 YP_002396400.1 CDS ykgF NC_011745.1 358704 360131 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase subunit with NAD(P)-binding domain and ferridoxin-like domain 358704..360131 Escherichia coli ED1a 7140947 YP_002396401.1 CDS ykgG NC_011745.1 360124 360819 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 360124..360819 Escherichia coli ED1a 7140948 YP_002396402.1 CDS ECED1_0347 NC_011745.1 360893 361090 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(360893..361090) Escherichia coli ED1a 7140950 YP_002396403.1 CDS ykgH NC_011745.1 361062 361730 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(361062..361730) Escherichia coli ED1a 7141832 YP_002396404.1 CDS ECED1_0349 NC_011745.1 361914 363905 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative adhesin complement(361914..363905) Escherichia coli ED1a 7140951 YP_002396405.1 CDS yahF NC_011745.1 364115 365425 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative enzyme with acyl-CoA domain 364115..365425 Escherichia coli ED1a 7141833 YP_002396406.1 CDS yahG NC_011745.1 365425 366843 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 365425..366843 Escherichia coli ED1a 7143400 YP_002396407.1 CDS yahI NC_011745.1 367090 368040 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7711027, 11523892; Product type pe : putative enzyme; putative carbamate kinase 367090..368040 Escherichia coli ED1a 7143401 YP_002396408.1 CDS yahJ NC_011745.1 368050 369432 D metallo-dependent hydrolase superfamily; deaminase with metallo-dependent hydrolase domain; putative deaminase 368050..369432 Escherichia coli ED1a 7143402 YP_002396409.1 CDS ECED1_0354 NC_011745.1 369696 370139 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 369696..370139 Escherichia coli ED1a 7143403 YP_002396410.1 CDS ECED1_0355 NC_011745.1 370390 371376 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; ribose ABC transporter substrate-binding protein 370390..371376 Escherichia coli ED1a 7141834 YP_002396411.1 CDS ECED1_0356 NC_011745.1 371410 372909 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ATP-binding protein of ABC sugar transport system 371410..372909 Escherichia coli ED1a 7141835 YP_002396412.1 CDS ECED1_0357 NC_011745.1 372902 373873 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; sugar ABC transporter permease 372902..373873 Escherichia coli ED1a 7141836 YP_002396413.1 CDS ECED1_0358 NC_011745.1 373840 374826 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; sugar ABC transporter permease 373840..374826 Escherichia coli ED1a 7141837 YP_002396414.1 CDS yahK NC_011745.1 374913 375962 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase, Zn-dependent and NAD(P)-binding 374913..375962 Escherichia coli ED1a 7141838 YP_002396415.1 CDS ECED1_0360 NC_011745.1 376554 376733 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 376554..376733 Escherichia coli ED1a 7140605 YP_002396416.1 CDS yahN NC_011745.1 376844 377515 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12879215; Product type t : transporter; neutral amino-acid efflux system complement(376844..377515) Escherichia coli ED1a 7141839 YP_002396417.1 CDS yahO NC_011745.1 377662 377937 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 377662..377937 Escherichia coli ED1a 7143405 YP_002396418.1 CDS prpR NC_011745.1 378038 379624 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9325432, 15805526; Product type r : regulator; DNA-binding transcriptional activator complement(378038..379624) Escherichia coli ED1a 7143406 YP_002396419.1 CDS prpB NC_011745.1 379863 380753 D catalyzes the formation of pyruvate and succinate from 2-methylisocitrate; 2-methylisocitrate lyase 379863..380753 Escherichia coli ED1a 7141185 YP_002396420.1 CDS prpC NC_011745.1 380913 382082 D catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity; methylcitrate synthase 380913..382082 Escherichia coli ED1a 7139137 YP_002396421.1 CDS prpD NC_011745.1 382116 383567 D functions in propionate metabolism; involved in isomerization of (2S,3S)-methylcitrate to (2R,3S)-methylisocitrate; also encodes minor aconitase or dehydratase activity; aconitase C; 2-methylcitrate dehydratase 382116..383567 Escherichia coli ED1a 7139138 YP_002396422.1 CDS prpE NC_011745.1 383607 385493 D catalyzes the formation of propionyl-CoA using propionate as a substrate; PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A; not expressed in Escherichia coli when grown on propionate/minimal media; ATP-dependent; propionyl-CoA synthetase 383607..385493 Escherichia coli ED1a 7139139 YP_002396423.1 CDS codB NC_011745.1 385724 386983 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92349961; Product type t : transporter; cytosine permease 385724..386983 Escherichia coli ED1a 7141102 YP_002396424.1 CDS codA NC_011745.1 386973 388256 D Catalyzes the deamination of cytosine to uracil and ammonia; cytosine deaminase 386973..388256 Escherichia coli ED1a 7142037 YP_002396425.1 CDS lacA NC_011745.1 388377 388988 R transfers acetyl group from acetyl-CoA to the 6-hydroxyl of galactopyranosides; exact physiological role is unknown; galactoside O-acetyltransferase complement(388377..388988) Escherichia coli ED1a 7142036 YP_002396426.1 CDS lacY NC_011745.1 389054 390307 R lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments; galactoside permease complement(389054..390307) Escherichia coli ED1a 7141864 YP_002396427.1 CDS lacZ NC_011745.1 390359 393433 R forms a homotetramer; hydrolyzes lactose disaccharide to galactose and glucose; converts lactose to allolactose which is the natural inducer of the lac operon; beta-D-galactosidase complement(390359..393433) Escherichia coli ED1a 7141866 YP_002396428.1 CDS lacI NC_011745.1 393556 394638 R transcriptional repressor of lac operon; forms a homotetramer as a dimer of dimers; binds specific sites in lac operon resulting in DNA looping between the operators; binds allolactose as inducer; lac repressor complement(393556..394638) Escherichia coli ED1a 7141867 YP_002396429.1 CDS mhpR NC_011745.1 394715 395629 R activator of 3-phenylpropionic acid catabolism; DNA-binding transcriptional activator MhpR complement(394715..395629) Escherichia coli ED1a 7141865 YP_002396430.1 CDS mhpA NC_011745.1 395740 397404 D catalyzes the formation of 3-(2,3-dihydroxyphenyl)propionate from 3-(3-hydroxyphenyl)propionate; 3-(3-hydroxyphenyl)propionate hydroxylase 395740..397404 Escherichia coli ED1a 7142275 YP_002396431.1 CDS mhpB NC_011745.1 397406 398350 D catalyzes the cleavage of 3-(2,3-dihydroxyphenyl) propionate into 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate; part of the 3-phenylpropionic acid degradation pathway; member of the protocatechuate 4,5-dioxygenase family; 3-(2,3-dihydroxyphenyl)propionate dioxygenase 397406..398350 Escherichia coli ED1a 7142269 YP_002396432.1 CDS mhpC NC_011745.1 398353 399234 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87008429, 94002258, 15663942; Product type e : enzyme; 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase 398353..399234 Escherichia coli ED1a 7142270 YP_002396433.1 CDS mhpD NC_011745.1 399244 400053 D catalyzes the formation of 2-keto-4-hydroxypentanoic acid from 2-hydroxypentadienoic acid; 2-keto-4-pentenoate hydratase 399244..400053 Escherichia coli ED1a 7142271 YP_002396434.1 CDS mhpF NC_011745.1 400050 401000 D catalyzes the formation of acetyl-CoA from acetalaldehyde; acetaldehyde dehydrogenase 400050..401000 Escherichia coli ED1a 7142272 YP_002396435.1 CDS mhpE NC_011745.1 400997 402010 D catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate; 4-hydroxy-2-ketovalerate aldolase 400997..402010 Escherichia coli ED1a 7142274 YP_002396436.1 CDS mhpT NC_011745.1 402186 403397 D Evidence 2b : Function of strongly homologous gene; PubMedId : 7961399; Product type t : transporter; putative 3-hydroxyphenylpropionic transporter MhpT 402186..403397 Escherichia coli ED1a 7142273 YP_002396437.1 CDS yaiL NC_011745.1 403499 404038 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15115803, 12878731, 13129938; Product type e : enzyme; nucleoprotein/polynucleotide-associated enzyme 403499..404038 Escherichia coli ED1a 7138977 YP_002396438.1 CDS frmB NC_011745.1 404265 405098 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16567800, 15466022; Product type e : enzyme; S-formylglutathione hydrolase complement(404265..405098) Escherichia coli ED1a 7143412 YP_002396439.1 CDS frmA NC_011745.1 405191 406300 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15466022, 87172301, 1731906; Product type e : enzyme; alcohol dehydrogenase class III/glutathione-dependent formaldehyde dehydrogenase complement(405191..406300) Escherichia coli ED1a 7142172 YP_002396440.1 CDS frmR NC_011745.1 406335 406610 R formaldehyde-induced negative regulator of the frmRAB operon; regulator protein FrmR complement(406335..406610) Escherichia coli ED1a 7142171 YP_002396441.1 CDS yaiX NC_011745.1 407573 408283 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transferase complement(407573..408283) Escherichia coli ED1a 7143414 YP_002396442.1 CDS yaiP NC_011745.1 408132 409328 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-associated glycosyltransferase complement(408132..409328) Escherichia coli ED1a 7143418 YP_002396443.1 CDS yaiS NC_011745.1 409338 410024 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(409338..410024) Escherichia coli ED1a 7143415 YP_002396444.1 CDS tauA NC_011745.1 410617 411579 D with TauB and TauC is responsible for taurine uptake.; taurine transporter substrate binding subunit 410617..411579 Escherichia coli ED1a 7143416 YP_002396445.1 CDS tauB NC_011745.1 411592 412359 D Part of the ABC transporter complex tauABC involved in taurine import; taurine transporter ATP-binding subunit 411592..412359 Escherichia coli ED1a 7141517 YP_002396446.1 CDS tauC NC_011745.1 412356 413183 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9401024, 96404792; Product type t : transporter; taurine transporter subunit 412356..413183 Escherichia coli ED1a 7141518 YP_002396447.1 CDS tauD NC_011745.1 413180 414031 D catalyzes the conversion of taurine (2-aminoethanesulfonate) to sulfite and aminoacetaldehyde concurrently with the conversion of alpha-ketoglutarate to succinate and carbon dioxide; non-heme iron oxidase; allows the use of taurine as an alternative sulfur source; forms homodimers; taurine dioxygenase 413180..414031 Escherichia coli ED1a 7141519 YP_002396448.1 CDS hemB NC_011745.1 414071 415045 R catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase complement(414071..415045) Escherichia coli ED1a 7141520 YP_002396449.1 CDS insB NC_011745.1 415220 415723 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' complement(415220..415723) Escherichia coli ED1a 7139866 YP_002396450.1 CDS insA NC_011745.1 415642 415917 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA complement(415642..415917) Escherichia coli ED1a 7141137 YP_002396451.1 CDS ampH NC_011745.1 416099 417256 R this protein has no known enzymatic function; beta-lactam binding protein AmpH complement(416099..417256) Escherichia coli ED1a 7141114 YP_002396452.1 CDS sbmA NC_011745.1 417608 418828 D in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope; transport protein 417608..418828 Escherichia coli ED1a 7143710 YP_002396453.1 CDS yaiW NC_011745.1 418841 419935 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative lipoprotein 418841..419935 Escherichia coli ED1a 7141374 YP_002396454.1 CDS yaiY NC_011745.1 419993 420301 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(419993..420301) Escherichia coli ED1a 7143417 YP_002396455.1 CDS yaiZ NC_011745.1 420429 420773 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 420429..420773 Escherichia coli ED1a 7143419 YP_002396456.1 CDS ddl NC_011745.1 420797 421891 R D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A complement(420797..421891) Escherichia coli ED1a 7143420 YP_002396457.1 CDS yaiB NC_011745.1 422354 422614 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 422354..422614 Escherichia coli ED1a 7143080 YP_002396458.1 CDS phoA NC_011745.1 422715 424130 D Evidence 1b : Function experimentally demonstrated in the studied species; Product type e : enzyme; alkaline phosphatase 422715..424130 Escherichia coli ED1a 7143408 YP_002396459.1 CDS psiF NC_011745.1 424249 424569 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3533724, 2160940; Product type f : factor; hypothetical protein 424249..424569 Escherichia coli ED1a 7144102 YP_002396460.1 CDS adrA NC_011745.1 424671 425786 D catalyzes the conversion of 2 GTP into c-di-GMP; adrA overexpression induces cellulose biosynthesis, cell adherence to abiotic surfaces and swimming and swarming motility; AdrA acts post-transcriptionally on the bcsABZC operon activating cellulose biosynthesis; diguanylate cyclase AdrA 424671..425786 Escherichia coli ED1a 7141189 YP_002396461.1 CDS proC NC_011745.1 425803 426612 R catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase complement(425803..426612) Escherichia coli ED1a 7143409 YP_002396462.1 CDS yaiI NC_011745.1 426732 427190 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 426732..427190 Escherichia coli ED1a 7139129 YP_002396463.1 CDS aroL NC_011745.1 427373 427897 D type II enzyme similar to type I but differentially regulated and with a lower Km; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase II 427373..427897 Escherichia coli ED1a 7143411 YP_002396464.1 CDS yaiA NC_011745.1 427947 428138 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 427947..428138 Escherichia coli ED1a 7142632 YP_002396465.1 CDS aroM NC_011745.1 428396 429073 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 86085675, 3001025; hypothetical protein 428396..429073 Escherichia coli ED1a 7143407 YP_002396466.1 CDS yaiE NC_011745.1 429145 429429 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 429145..429429 Escherichia coli ED1a 7142633 YP_002396467.1 CDS ykiA NC_011745.1 429637 429915 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 429637..429915 Escherichia coli ED1a 7143410 YP_002396468.1 CDS rdgC NC_011745.1 430073 430984 R Required for efficient pilin antigenic variation; recombination associated protein complement(430073..430984) Escherichia coli ED1a 7140956 YP_002396469.1 CDS mak NC_011745.1 431109 432017 D catalyzes phosphorylation of fructose; cytosolic enzyme; fructokinase 431109..432017 Escherichia coli ED1a 7141572 YP_002396470.1 CDS araJ NC_011745.1 432286 433470 R member of the major facilitator superfamily (MFS) of transporters; unknown function; may be associated with transport or processing of arabinose polymers; MFS transport protein AraJ complement(432286..433470) Escherichia coli ED1a 7141943 YP_002396471.1 CDS sbcC NC_011745.1 433596 436739 R with SbcD cleaves DNA hairpin structures; also has 5' single-strand endonuclease activity; exonuclease subunit SbcC complement(433596..436739) Escherichia coli ED1a 7142604 YP_002396472.1 CDS sbcD NC_011745.1 436736 437938 R with SbcC cleaves DNA hairpin structure, also has 5' single-strand endonuclease activity; exonuclease subunit SbcD complement(436736..437938) Escherichia coli ED1a 7141372 YP_002396473.1 CDS phoB NC_011745.1 438128 438817 D two component response regulator for the phosphate regulon; PhoR phosphorylates PhoB; transcriptional regulator PhoB 438128..438817 Escherichia coli ED1a 7141373 YP_002396474.1 CDS phoR NC_011745.1 438875 440170 D membrane-associated histidine protein kinase that phosphorylates phoB in response to environmental signals as part of the two-component phosphate regulatory system phoR/phoB; phosphate regulon sensor protein 438875..440170 Escherichia coli ED1a 7144103 YP_002396475.1 CDS ECED1_0423 NC_011745.1 440181 440291 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(440181..440291) Escherichia coli ED1a 7144108 YP_002396476.1 CDS brnQ NC_011745.1 440577 441896 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 3078876, 6998958, 3550103, 7984428; Product type t : transporter; branched chain amino acid transporter 440577..441896 Escherichia coli ED1a 7141840 YP_002396477.1 CDS proY NC_011745.1 441972 443345 D cryptic permease that may be involved in the transport of proline across the inner membrane; in Salmonella typhimurium, the proY gene is silent unless overexpressed on a multicopy plasmid or activated by a proZ mutation; putative proline-specific permease 441972..443345 Escherichia coli ED1a 7140462 YP_002396478.1 CDS malZ NC_011745.1 443501 445318 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92184757, 1706703, 1918057; Product type e : enzyme; maltodextrin glucosidase 443501..445318 Escherichia coli ED1a 7139136 YP_002396479.1 CDS acpH NC_011745.1 445323 445904 R Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP; acyl carrier protein phosphodiesterase complement(445323..445904) Escherichia coli ED1a 7142206 YP_002396480.1 CDS queA NC_011745.1 445997 447067 D Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine:tRNA ribosyltransferase-isomerase 445997..447067 Escherichia coli ED1a 7143645 YP_002396481.1 CDS tgt NC_011745.1 447122 448249 D Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 447122..448249 Escherichia coli ED1a 7141244 YP_002396482.1 CDS yajC NC_011745.1 448272 448604 D member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 448272..448604 Escherichia coli ED1a 7141538 YP_002396483.1 CDS secD NC_011745.1 448632 450479 D part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 448632..450479 Escherichia coli ED1a 7143421 YP_002396484.1 CDS secF NC_011745.1 450490 451461 D forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 450490..451461 Escherichia coli ED1a 7141387 YP_002396485.1 CDS yajD NC_011745.1 451591 451938 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 451591..451938 Escherichia coli ED1a 7141389 YP_002396486.1 CDS tsx NC_011745.1 451976 452860 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91092502, 91358319, 93352541; Product type m : membrane component; nucleoside channel phage T6/colicin K receptor complement(451976..452860) Escherichia coli ED1a 7143422 YP_002396487.1 CDS yajI NC_011745.1 453159 453698 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein complement(453159..453698) Escherichia coli ED1a 7140837 YP_002396488.1 CDS nrdR NC_011745.1 453849 454298 D Evidence 2b : Function of strongly homologous gene; Product type r : regulator; transcriptional regulator NrdR 453849..454298 Escherichia coli ED1a 7143424 YP_002396489.1 CDS ribD NC_011745.1 454302 455405 D riboflavin biosynthesis protein which catalyzes the deamination and reduction steps in the riboflavin biosynthesis pathway; catalyzes the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 5-amino-6-(5-phosphoribitylamino)uracil; bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase 454302..455405 Escherichia coli ED1a 7139927 YP_002396490.1 CDS ribH NC_011745.1 455494 455964 D RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 455494..455964 Escherichia coli ED1a 7141410 YP_002396491.1 CDS nusB NC_011745.1 455984 456403 D Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 455984..456403 Escherichia coli ED1a 7141411 YP_002396492.1 CDS thiL NC_011745.1 456481 457458 D catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase 456481..457458 Escherichia coli ED1a 7139960 YP_002396493.1 CDS pgpA NC_011745.1 457436 457954 D hydrolyzes phosphatidylglycerophosphate to produce phosphatidylglycerol and phosphate; phosphatidylglycerophosphatase A 457436..457954 Escherichia coli ED1a 7141546 YP_002396494.1 CDS yajO NC_011745.1 458008 458982 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15292217, 16077126; Product type e : enzyme; aldoketo-oxidoreductase, NADP-binding complement(458008..458982) Escherichia coli ED1a 7144078 YP_002396495.1 CDS dxs NC_011745.1 459037 460899 R catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase complement(459037..460899) Escherichia coli ED1a 7143426 YP_002396496.1 CDS ispA NC_011745.1 460924 461823 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89291702, 91210228; Product type e : enzyme; geranyltranstransferase complement(460924..461823) Escherichia coli ED1a 7139759 YP_002396497.1 CDS xseB NC_011745.1 461823 462065 R catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit complement(461823..462065) Escherichia coli ED1a 7142462 YP_002396498.1 CDS thiI NC_011745.1 462271 463719 D Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 462271..463719 Escherichia coli ED1a 7139210 YP_002396499.1 CDS yajL NC_011745.1 463773 464363 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 97039868, 99173753, 99311269; DJ-1 family protein complement(463773..464363) Escherichia coli ED1a 7141545 YP_002396500.1 CDS panE NC_011745.1 464326 465237 R ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis; 2-dehydropantoate 2-reductase complement(464326..465237) Escherichia coli ED1a 7143425 YP_002396501.1 CDS yajQ NC_011745.1 465405 465896 D putative nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription; putative nucleotide-binding protein 465405..465896 Escherichia coli ED1a 7144042 YP_002396502.1 CDS yajR NC_011745.1 466024 467388 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter complement(466024..467388) Escherichia coli ED1a 7143427 YP_002396503.1 CDS cyoE NC_011745.1 467537 468427 R converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase complement(467537..468427) Escherichia coli ED1a 7143428 YP_002396504.1 CDS cyoD NC_011745.1 468439 468768 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90330636, 90366572, 92345252, 9378722, 98021084, 11017202, 2162835; Product type c : carrier; cytochrome o ubiquinol oxidase subunit IV complement(468439..468768) Escherichia coli ED1a 7142106 YP_002396505.1 CDS cyoC NC_011745.1 468768 469382 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90330636, 92345252, 93349845, 9378722, 98021084, 11017202, 2162835, 2168206; Product type c : carrier; cytochrome o ubiquinol oxidase subunit III complement(468768..469382) Escherichia coli ED1a 7142105 YP_002396506.1 CDS cyoB NC_011745.1 469372 471363 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90330636, 92345252, 93349845, 9378722, 98021084, 11017202, 2162835, 2168206; Product type c : carrier; cytochrome o ubiquinol oxidase subunit I complement(469372..471363) Escherichia coli ED1a 7142104 YP_002396507.1 CDS cyoA NC_011745.1 471385 472332 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92112945, 92371427, 9378722, 98021084, 11017202, 1322173, 2162835, 2162837, 2165491, 2168206, 8231804, 8618822; Product type c : carrier; cytochrome o ubiquinol oxidase subunit II complement(471385..472332) Escherichia coli ED1a 7142103 YP_002396508.1 CDS ampG NC_011745.1 472792 474267 R in Escherichia coli this protein is a permease involved in peptidoglycan recycling; member of major facilitator superfamily; MFS; inner membrane protein; muropeptide transporter complement(472792..474267) Escherichia coli ED1a 7142102 YP_002396509.1 CDS yajG NC_011745.1 474311 474889 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein complement(474311..474889) Escherichia coli ED1a 7143709 YP_002396510.1 CDS bolA NC_011745.1 475194 475511 D positive transcriptional regulator of morphogenetic pathway; controlling several genes involved in oxidative stress, acid stress, heat shock, osmotic shock, and carbon-starvation stress; transcriptional regulator BolA 475194..475511 Escherichia coli ED1a 7143423 YP_002396511.1 CDS ECED1_0459 NC_011745.1 475445 475708 D Evidence 6 : Doubtful CDS; hypothetical protein 475445..475708 Escherichia coli ED1a 7140461 YP_002396512.1 CDS tig NC_011745.1 475855 477153 D Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 475855..477153 Escherichia coli ED1a 7141841 YP_002396513.1 CDS clpP NC_011745.1 477399 478022 D hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 477399..478022 Escherichia coli ED1a 7141557 YP_002396514.1 CDS clpX NC_011745.1 478148 479422 D binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 478148..479422 Escherichia coli ED1a 7139376 YP_002396515.1 CDS lon NC_011745.1 479610 481964 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10094703, 14665623, 8939438, 91072263, 97137085, 2984174, 3042779, 3289547, 7988699, 8226758, 8294008; Product type e : enzyme; DNA-binding ATP-dependent protease La 479610..481964 Escherichia coli ED1a 7140767 YP_002396516.1 CDS hupB NC_011745.1 482173 482445 D histone-like DNA-binding protein; transcriptional regulator HU subunit beta 482173..482445 Escherichia coli ED1a 7141906 YP_002396517.1 CDS ppiD NC_011745.1 482637 484508 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9670013; Product type e : enzyme; peptidyl-prolyl cis-trans isomerase D 482637..484508 Escherichia coli ED1a 7140179 YP_002396518.1 CDS ybaV NC_011745.1 484659 485030 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 484659..485030 Escherichia coli ED1a 7139106 YP_002396519.1 CDS ybaW NC_011745.1 485136 485534 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 485136..485534 Escherichia coli ED1a 7138900 YP_002396520.1 CDS queC NC_011745.1 485586 486281 R YbaX; catalyzes the transformation of GTP to 7-cyano-7-deazaguanine (preQ0), as one of the early reactions of quenosine biosynthesis; quenosine is a modified nucleoside that occurs at the wobble position of GUN anticodons in tRNAs for Asn, Asp, Tyr, and His; queuosine biosynthesis protein QueC complement(485586..486281) Escherichia coli ED1a 7138901 YP_002396521.1 CDS ybaE NC_011745.1 486346 488046 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(486346..488046) Escherichia coli ED1a 7141245 YP_002396522.1 CDS cof NC_011745.1 488146 488964 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15292217; Product type e : enzyme; thiamin pyrimidine pyrophosphate hydrolase 488146..488964 Escherichia coli ED1a 7143431 YP_002396523.1 CDS ybaO NC_011745.1 488889 489575 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator (Lrp-like) 488889..489575 Escherichia coli ED1a 7142038 YP_002396524.1 CDS mdlA NC_011745.1 489605 491377 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 94124004, 10850996; Product type pt : putative transporter; putative multidrug transporter membrane\ATP-binding proteins 489605..491377 Escherichia coli ED1a 7138895 YP_002396525.1 CDS mdlB NC_011745.1 491370 493151 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 94124004; Product type pt : putative transporter; putative multidrug transporter membrane\ATP-binding proteins 491370..493151 Escherichia coli ED1a 7142220 YP_002396526.1 CDS glnK NC_011745.1 493332 493670 D indirectly regulates nitrogen metabolism; at high nitrogen levels P-II 2 prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II 2 is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; functionally it is equivalent to protein P-II (GlnB), but itsexpression is driven by the presence of uridylyltransferase, nitrogen regulator I, and the absence of ammonia.; nitrogen regulatory protein P-II 2 493332..493670 Escherichia coli ED1a 7142221 YP_002396527.1 CDS amtB NC_011745.1 493700 494986 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 22020597, 9618533, 10931328, 1645722, 7984428; Product type t : transporter; ammonium transporter 493700..494986 Escherichia coli ED1a 7142959 YP_002396528.1 CDS tesB NC_011745.1 495035 495895 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86139906, 91250410, 10876240; Product type e : enzyme; acyl-CoA thioesterase II complement(495035..495895) Escherichia coli ED1a 7142525 YP_002396529.1 CDS ybaY NC_011745.1 496113 496685 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative lipoprotein 496113..496685 Escherichia coli ED1a 7141535 YP_002396530.1 CDS ybaZ NC_011745.1 496716 497105 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative methylated DNA-protein cysteine alkyltransferase complement(496716..497105) Escherichia coli ED1a 7138902 YP_002396531.1 CDS ybaA NC_011745.1 497406 497759 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 497406..497759 Escherichia coli ED1a 7144166 YP_002396532.1 CDS ylaB NC_011745.1 497801 499351 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(497801..499351) Escherichia coli ED1a 7143429 YP_002396533.1 CDS ylaC NC_011745.1 499515 499985 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(499515..499985) Escherichia coli ED1a 7140957 YP_002396534.1 CDS maa NC_011745.1 500101 500652 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82180540, 91310703, 9600841; Product type e : enzyme; maltose O-acetyltransferase complement(500101..500652) Escherichia coli ED1a 7140958 YP_002396535.1 CDS hha NC_011745.1 500825 501043 R with Hns involved in transcriptional regulation of hemolysin; non-specific DNA-binding protein which affects the production of multiple proteins; hemolysin expression-modulating protein complement(500825..501043) Escherichia coli ED1a 7141939 YP_002396536.1 CDS ybaJ NC_011745.1 501069 501443 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1956303, 7984428, 14645275; hypothetical protein complement(501069..501443) Escherichia coli ED1a 7139883 YP_002396537.1 CDS acrB NC_011745.1 501988 505137 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12351840, 12654283, 15111118, 15155734, 21450803, 94012493, 10920254, 7651136; Product type t : transporter; multidrug efflux system protein complement(501988..505137) Escherichia coli ED1a 7143432 YP_002396538.1 CDS acrA NC_011745.1 505160 506353 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15155734, 21450803, 383699, 390095, 94012493, 10920254, 7651136; Product type t : transporter; multidrug efflux system complement(505160..506353) Escherichia coli ED1a 7143650 YP_002396539.1 CDS acrR NC_011745.1 506495 507142 D regulates the acrAB operon which is involved in susceptibility to dephalothin and cephaloridine; DNA-binding transcriptional repressor AcrR 506495..507142 Escherichia coli ED1a 7143649 YP_002396540.1 CDS kefA NC_011745.1 507270 510632 D small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS; potassium efflux protein KefA 507270..510632 Escherichia coli ED1a 7143654 YP_002396541.1 CDS ybaM NC_011745.1 510844 511005 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(510844..511005) Escherichia coli ED1a 7142505 YP_002396542.1 CDS priC NC_011745.1 511019 511546 R PriC; protein involved in DNA replication; part of the primosome, a protein complex required to restart stalled replication forks; binds the complex formed by PriA, PriB and DNA; PriC-dependent primosome requires a gap to restart DNA replication; stimulates Rep activity at stalled forks; primosomal replication protein N'' complement(511019..511546) Escherichia coli ED1a 7143435 YP_002396543.1 CDS ybaN NC_011745.1 511616 511993 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 511616..511993 Escherichia coli ED1a 7139121 YP_002396544.1 CDS apt NC_011745.1 512146 512697 D catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 512146..512697 Escherichia coli ED1a 7138873 YP_002396545.1 CDS dnaX NC_011745.1 512826 514757 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 512826..514757 Escherichia coli ED1a 7142594 YP_002396546.1 CDS ybaB NC_011745.1 514810 515139 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 15322138, 1698765, 2674903; hypothetical protein 514810..515139 Escherichia coli ED1a 7140512 YP_002396547.1 CDS recR NC_011745.1 515139 515744 D involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 515139..515744 Escherichia coli ED1a 7143430 YP_002396548.1 CDS htpG NC_011745.1 515854 517728 D molecular chaperone; heat shock protein 90 515854..517728 Escherichia coli ED1a 7141584 YP_002396549.1 CDS adk NC_011745.1 517909 518553 D essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 517909..518553 Escherichia coli ED1a 7140172 YP_002396550.1 CDS hemH NC_011745.1 518685 519647 D protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 518685..519647 Escherichia coli ED1a 7143665 YP_002396551.1 CDS aes NC_011745.1 519644 520603 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9401025, 98244813, 2051480, 7721718; Product type e : enzyme; acetyl esterase complement(519644..520603) Escherichia coli ED1a 7139872 YP_002396552.1 CDS gsk NC_011745.1 520755 522059 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90155203, 95238302, 2051480; Product type e : enzyme; inosine/guanosine kinase 520755..522059 Escherichia coli ED1a 7143669 YP_002396553.1 CDS ybaL NC_011745.1 522189 523865 R YbaL; member of the CPA-2 family of antiporters; uncharacterized protein; putative cation:proton antiport protein complement(522189..523865) Escherichia coli ED1a 7143029 YP_002396554.1 CDS fsr NC_011745.1 524103 525323 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21450803, 97074653, 8917080; Product type t : transporter; fosmidomycin efflux system protein complement(524103..525323) Escherichia coli ED1a 7143434 YP_002396555.1 CDS ECED1_0503 NC_011745.1 525359 525544 D Evidence 6 : Doubtful CDS; hypothetical protein 525359..525544 Escherichia coli ED1a 7142186 YP_002396556.1 CDS ushA NC_011745.1 525541 527193 D catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides; bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic 525541..527193 Escherichia coli ED1a 7141842 YP_002396557.1 CDS ybaK NC_011745.1 527230 527709 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(527230..527709) Escherichia coli ED1a 7140150 YP_002396558.1 CDS ybaP NC_011745.1 527913 528707 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(527913..528707) Escherichia coli ED1a 7140744 YP_002396559.1 CDS ECED1_0508 NC_011745.1 528810 529142 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative RelE/ParE family protein, cytotoxic translational repressor of toxin-antitoxin stability system 528810..529142 Escherichia coli ED1a 7138896 YP_002396560.1 CDS ybaQ NC_011745.1 529178 529519 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 529178..529519 Escherichia coli ED1a 7141843 YP_002396561.1 CDS copA NC_011745.1 529577 532081 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12351646, 20105527, 11167016, 11500054, 9868784; Product type t : transporter; copper exporting ATPase complement(529577..532081) Escherichia coli ED1a 7138897 YP_002396562.1 CDS ybaS NC_011745.1 532343 533275 D catalyzes the formation of glutamate from glutamine; glutaminase 532343..533275 Escherichia coli ED1a 7142039 YP_002396563.1 CDS ybaT NC_011745.1 533278 534570 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative nitrogen-containing metabolite transporter 533278..534570 Escherichia coli ED1a 7138898 YP_002396564.1 CDS cueR NC_011745.1 534695 535102 D activator of copper-responsive regulon genes; DNA-binding transcriptional regulator CueR 534695..535102 Escherichia coli ED1a 7138899 YP_002396565.1 CDS ECED1_0514 NC_011745.1 535103 536326 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(535103..536326) Escherichia coli ED1a 7142082 YP_002396566.1 CDS ybbJ NC_011745.1 536444 536899 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(536444..536899) Escherichia coli ED1a 7141844 YP_002396567.1 CDS ybbK NC_011745.1 536899 537816 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative protease, membrane anchored complement(536899..537816) Escherichia coli ED1a 7138906 YP_002396568.1 CDS ybbL NC_011745.1 537962 538639 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATP-binding protein YbbL 537962..538639 Escherichia coli ED1a 7138907 YP_002396569.1 CDS ybbM NC_011745.1 538626 539405 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative permease of an ABC transporter 538626..539405 Escherichia coli ED1a 7138908 YP_002396570.1 CDS ybbN NC_011745.1 539468 540322 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative thioredoxin domain-containing protein complement(539468..540322) Escherichia coli ED1a 7138909 YP_002396571.1 CDS ybbO NC_011745.1 540383 541192 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; short chain dehydrogenase complement(540383..541192) Escherichia coli ED1a 7138910 YP_002396572.1 CDS tesA NC_011745.1 541182 541808 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91270121, 91324311, 93163029, 93252782, 94179121, 99353977, 1864840, 8432696, 8098033; Product type e : enzyme; multifunctional acyl-CoA thioesterase I/protease I/lysophospholipase L1 complement(541182..541808) Escherichia coli ED1a 7138911 YP_002396573.1 CDS ybbA NC_011745.1 541776 542462 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATP-binding protein YbbA 541776..542462 Escherichia coli ED1a 7141534 YP_002396574.1 CDS ybbP NC_011745.1 542459 544873 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type t : transporter; putative ABC transporter permease 542459..544873 Escherichia coli ED1a 7138904 YP_002396575.1 CDS ybbB NC_011745.1 545114 546208 R catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA; tRNA 2-selenouridine synthase complement(545114..546208) Escherichia coli ED1a 7138912 YP_002396576.1 CDS ybbS NC_011745.1 546277 547203 R activator of the allDC-ylbA operon involved in allantoin utilization; DNA-binding transcriptional activator AllS complement(546277..547203) Escherichia coli ED1a 7138905 YP_002396577.1 CDS allA NC_011745.1 547433 547915 D catalyzes the formation of glyoxylate from (S)-ureidoglycolate; ureidoglycolate hydrolase 547433..547915 Escherichia coli ED1a 7138913 YP_002396578.1 CDS allR NC_011745.1 547993 548808 D regulates operons involved in the utilization of allantoin; DNA-binding transcriptional repressor AllR 547993..548808 Escherichia coli ED1a 7143690 YP_002396579.1 CDS gcl NC_011745.1 548808 550676 D catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate; glyoxylate carboligase 548808..550676 Escherichia coli ED1a 7143694 YP_002396580.1 CDS glxR NC_011745.1 550776 551654 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20069628; Product type e : enzyme; tartronate semialdehyde reductase, NADH-dependent 550776..551654 Escherichia coli ED1a 7143165 YP_002396581.1 CDS ybbW NC_011745.1 551824 553185 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1293888; Product type t : transporter; allantoin permease 551824..553185 Escherichia coli ED1a 7142989 YP_002396582.1 CDS allB NC_011745.1 553338 554699 D Plays a crucial role on both purine and pyrimidine metabolism; allantoinase 553338..554699 Escherichia coli ED1a 7138914 YP_002396583.1 CDS ybbY NC_011745.1 554755 556056 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative purine permease YbbY 554755..556056 Escherichia coli ED1a 7143691 YP_002396584.1 CDS glxK NC_011745.1 556078 557223 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20069628; Product type e : enzyme; glycerate kinase II 556078..557223 Escherichia coli ED1a 7138915 YP_002396585.1 CDS ylbA NC_011745.1 557352 558137 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(557352..558137) Escherichia coli ED1a 7142988 YP_002396586.1 CDS allC NC_011745.1 558148 559383 R allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide; allantoate amidohydrolase complement(558148..559383) Escherichia coli ED1a 7140959 YP_002396587.1 CDS allD NC_011745.1 559405 560454 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12460564, 20069628, 69151449; Product type e : enzyme; ureidoglycolate dehydrogenase complement(559405..560454) Escherichia coli ED1a 7143692 YP_002396588.1 CDS fdrA NC_011745.1 560771 562438 D multicopy suppressor of dominant negative ftsH mutations; membrane protein FdrA 560771..562438 Escherichia coli ED1a 7143693 YP_002396589.1 CDS ylbE NC_011745.1 562448 563707 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 562448..563707 Escherichia coli ED1a 7144145 YP_002396590.1 CDS ylbF NC_011745.1 563718 564533 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 563718..564533 Escherichia coli ED1a 7140960 YP_002396591.1 CDS ybcF NC_011745.1 564530 565423 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2464576, 2644189, 7920643, 7940673, 7984428; Product type pe : putative enzyme; carbamate kinase 564530..565423 Escherichia coli ED1a 7140961 YP_002396592.1 CDS purK NC_011745.1 565956 567023 R With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit complement(565956..567023) Escherichia coli ED1a 7138916 YP_002396593.1 CDS purE NC_011745.1 567020 567529 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10074353, 8117684, 89123018, 89123019, 92287929, 10574791; Product type e : enzyme; N5-carboxyaminoimidazole ribonucleotide mutase complement(567020..567529) Escherichia coli ED1a 7141220 YP_002396594.1 CDS ECED1_0543 NC_011745.1 567625 567954 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein complement(567625..567954) Escherichia coli ED1a 7141217 YP_002396595.1 CDS lpxH NC_011745.1 568065 568787 R catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine; UDP-2,3-diacylglucosamine hydrolase complement(568065..568787) Escherichia coli ED1a 7141845 YP_002396596.1 CDS ppiB NC_011745.1 568790 569284 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90272647, 91175755, 1606970, 1864365, 8601841, 9298646, 9600841; Product type e : enzyme; peptidyl-prolyl cis-trans isomerase B complement(568790..569284) Escherichia coli ED1a 7141921 YP_002396597.1 CDS cysS NC_011745.1 569458 570843 D catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 569458..570843 Escherichia coli ED1a 7139104 YP_002396598.1 CDS ybcI NC_011745.1 570879 571400 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(570879..571400) Escherichia coli ED1a 7143045 YP_002396599.1 CDS ybcJ NC_011745.1 571508 571720 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12837795, 1748668, 7567469; Product type pr : putative regulator; hypothetical protein complement(571508..571720) Escherichia coli ED1a 7138918 YP_002396600.1 CDS folD NC_011745.1 571722 572588 R catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase complement(571722..572588) Escherichia coli ED1a 7138919 YP_002396601.1 CDS ECED1_0550 NC_011745.1 572638 572826 D Evidence 6 : Doubtful CDS; hypothetical protein 572638..572826 Escherichia coli ED1a 7142158 YP_002396602.1 CDS tfaQ NC_011745.1 573577 573933 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail fiber assembly protein 573577..573933 Escherichia coli ED1a 7142442 YP_002396603.1 CDS ybcY NC_011745.1 573988 574572 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative AdoMet-dependent methyltransferase; DLP12 prophage complement(573988..574572) Escherichia coli ED1a 7141537 YP_002396604.1 CDS insB NC_011745.1 575113 575616 R Evidence 2b : Function of strongly homologous gene; PubMedId : 12770720, 6265806; Product type h : extrachromosomal origin; Insertion element IS1 1/5/6 protein insB complement(575113..575616) Escherichia coli ED1a 7138922 YP_002396605.1 CDS insA NC_011745.1 575535 575810 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA complement(575535..575810) Escherichia coli ED1a 7141138 YP_002396606.1 CDS ybcH NC_011745.1 577276 578166 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(577276..578166) Escherichia coli ED1a 7139975 YP_002396607.1 CDS nfrA NC_011745.1 578167 581139 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89359086, 94042873, 94042874; Product type m : membrane component; bacteriophage N4 receptor, outer membrane subunit complement(578167..581139) Escherichia coli ED1a 7138917 YP_002396608.1 CDS cusS NC_011745.1 583513 584955 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20461235, 11283292, 11399769; Product type r : regulator; sensor kinase CusS complement(583513..584955) Escherichia coli ED1a 7140380 YP_002396609.1 CDS cusR NC_011745.1 584945 585628 R response regulator in two-component regulatory system with CusS; regulates the copper efflux system; DNA-binding transcriptional activator CusR complement(584945..585628) Escherichia coli ED1a 7142088 YP_002396610.1 CDS cusC NC_011745.1 585785 587167 D with CusA, CusB and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system outer membrane protein CusC 585785..587167 Escherichia coli ED1a 7142087 YP_002396611.1 CDS cusF NC_011745.1 587191 587523 D Evidence 2b : Function of strongly homologous gene; PubMedId : 21125583, 11283292, 11399769, 12813074; Product type f : factor; periplasmic copper-binding protein 587191..587523 Escherichia coli ED1a 7142085 YP_002396612.1 CDS cusB NC_011745.1 587539 588762 D with CusA, CusC and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system membrane fusion protein CusB 587539..588762 Escherichia coli ED1a 7142086 YP_002396613.1 CDS cusA NC_011745.1 588774 591917 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20461235, 21125583, 21178899, 21450803, 11399769, 12813074, 1711024, 7984428; Product type t : transporter; copper/silver efflux system, membrane component 588774..591917 Escherichia coli ED1a 7142084 YP_002396614.1 CDS pheP NC_011745.1 591983 593401 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91267923, 94042931, 8626334; Product type t : transporter; phenylalanine transporter 591983..593401 Escherichia coli ED1a 7142083 YP_002396615.1 CDS ybdG NC_011745.1 593558 594805 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative channel membrane protein complement(593558..594805) Escherichia coli ED1a 7144084 YP_002396616.1 CDS nfnB NC_011745.1 594913 595566 R catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive; dihydropteridine reductase complement(594913..595566) Escherichia coli ED1a 7138927 YP_002396617.1 CDS ybdF NC_011745.1 595645 596013 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(595645..596013) Escherichia coli ED1a 7140376 YP_002396618.1 CDS ybdJ NC_011745.1 596093 596341 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(596093..596341) Escherichia coli ED1a 7138926 YP_002396619.1 CDS ybdK NC_011745.1 596407 597525 R ATP-dependent; carboxylate-amine ligase with weak glutamate--cysteine ligase activity; carboxylate-amine ligase complement(596407..597525) Escherichia coli ED1a 7138929 YP_002396620.1 CDS hokE NC_011745.1 597979 598131 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99291074; Product type f : factor; toxic polypeptide, small 597979..598131 Escherichia coli ED1a 7138930 YP_002396621.1 CDS entD NC_011745.1 598253 598882 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89313305, 90132534, 91035252, 8939709, 9214294; Product type e : enzyme; phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex complement(598253..598882) Escherichia coli ED1a 7139909 YP_002396622.1 CDS fes NC_011745.1 601609 602733 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92291125, 94198561, 2974033; Product type e : enzyme; enterobactin/ferric enterobactin esterase 601609..602733 Escherichia coli ED1a 7144157 YP_002396623.1 CDS ybdZ NC_011745.1 602736 602954 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 602736..602954 Escherichia coli ED1a 7144164 YP_002396624.1 CDS entF NC_011745.1 602951 606832 D with EntB, EntD, and EntE forms the multienzyme complex enterobactin synthase; EntF is the serine activating enzyme which catalyzes the formation of the amide and ester bonds of the cyclic enterobactin; enterobactin synthase subunit F 602951..606832 Escherichia coli ED1a 7138933 YP_002396625.1 CDS fepE NC_011745.1 607209 608213 D part of the ferric enterobactin transport system; necessary for enetrobactin uptake; ferric enterobactin transport protein FepE 607209..608213 Escherichia coli ED1a 7144161 YP_002396626.1 CDS fepC NC_011745.1 608210 609025 R with FepBDE is involved in the transport of ferric enterobactin; iron-enterobactin transporter ATP-binding protein complement(608210..609025) Escherichia coli ED1a 7144162 YP_002396627.1 CDS fepG NC_011745.1 609022 610014 R with FepBCD is involved in the transport of ferric enterobactin; iron-enterobactin transporter permease complement(609022..610014) Escherichia coli ED1a 7144159 YP_002396628.1 CDS fepD NC_011745.1 610011 611015 R with FepBCG is involved in the transport of ferric enterobactin; iron-enterobactin transporter membrane protein complement(610011..611015) Escherichia coli ED1a 7144163 YP_002396629.1 CDS ybdA NC_011745.1 611126 612376 D protein p43; inner membrane protein that exports enterobactin to the periplasmic space; member of the major facilitator superfamily (MFS) of transporters; enterobactin exporter EntS 611126..612376 Escherichia coli ED1a 7144160 YP_002396630.1 CDS fepB NC_011745.1 612380 613336 R with FepCDG is involved in the transport of ferric enterobactin; iron-enterobactin transporter periplasmic binding protein complement(612380..613336) Escherichia coli ED1a 7138923 YP_002396631.1 CDS entC NC_011745.1 613525 614700 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89123153, 90165423, 90241936, 2110093, 2139473; Product type e : enzyme; isochorismate synthase 1 613525..614700 Escherichia coli ED1a 7144158 YP_002396632.1 CDS entE NC_011745.1 614710 616320 D bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate; enterobactin synthase subunit E 614710..616320 Escherichia coli ED1a 7139796 YP_002396633.1 CDS entB NC_011745.1 616334 617191 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20183918, 90241937, 91035252, 9485415, 97361959, 2521621, 2521622; Product type e : enzyme; isochorismatase 616334..617191 Escherichia coli ED1a 7139798 YP_002396634.1 CDS entA NC_011745.1 617191 617937 D catalyzes the formation of 2,3-dihydroxybenzoate from 2,3-dihydro-2,3-dihydroxybenzoate; involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin; 2,3-dihydroxybenzoate-2,3-dehydrogenase 617191..617937 Escherichia coli ED1a 7139795 YP_002396635.1 CDS ybdB NC_011745.1 617940 618353 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2521621, 2521622, 15808744; Product type pe : putative enzyme; hypothetical protein 617940..618353 Escherichia coli ED1a 7139794 YP_002396636.1 CDS ybdD NC_011745.1 620741 620938 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 620741..620938 Escherichia coli ED1a 7142080 YP_002396637.1 CDS ybdH NC_011745.1 620948 622036 R member of the iron-containing alcohol dehydrogenase family; unknown function; hypothetical protein complement(620948..622036) Escherichia coli ED1a 7138925 YP_002396638.1 CDS ybdL NC_011745.1 622145 623305 D catalyzes the transfer of an amino moiety; putative aminotransferase 622145..623305 Escherichia coli ED1a 7138928 YP_002396639.1 CDS ibrB NC_011745.1 623306 623935 R Evidence 2b : Function of strongly homologous gene; PubMedId : 12057959; Product type r : regulator; immunoglobulin-binding regulator complement(623306..623935) Escherichia coli ED1a 7138931 YP_002396640.1 CDS ibrA NC_011745.1 623908 625128 R Evidence 2b : Function of strongly homologous gene; PubMedId : 12057959; Product type r : regulator; immunoglobulin-binding regulator complement(623908..625128) Escherichia coli ED1a 7140219 YP_002396641.1 CDS ybdO NC_011745.1 625275 626213 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative LysR-type DNA-binding transcriptional regulator complement(625275..626213) Escherichia coli ED1a 7140217 YP_002396642.1 CDS dsbG NC_011745.1 626382 627128 R Involved in disulfide bond formation; disulfide isomerase/thiol-disulfide oxidase complement(626382..627128) Escherichia coli ED1a 7138932 YP_002396643.1 CDS ahpC NC_011745.1 627500 628063 D with AhpF catalyzes the conversion of alkyl hydroperoxides to their corresponding alcohols; AhpC reduced the hydroperoxide substrate; alkyl hydroperoxide reductase subunit C 627500..628063 Escherichia coli ED1a 7140524 YP_002396644.1 CDS ahpF NC_011745.1 628234 629799 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89197774, 1592833; Product type e : enzyme; alkyl hydroperoxide reductase F52a subunit 628234..629799 Escherichia coli ED1a 7143681 YP_002396645.1 CDS uspG NC_011745.1 629920 630348 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12732303, 12071968; Product type f : factor; universal stress protein UP12 complement(629920..630348) Escherichia coli ED1a 7143682 YP_002396646.1 CDS rnk NC_011745.1 630705 631115 R Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation; nucleoside diphosphate kinase regulator complement(630705..631115) Escherichia coli ED1a 7139148 YP_002396647.1 CDS rna NC_011745.1 631345 632151 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90151658, 90264307, 2253883, 8188249; Product type e : enzyme; ribonuclease I complement(631345..632151) Escherichia coli ED1a 7141439 YP_002396648.1 CDS citT NC_011745.1 632265 633728 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9696764; Product type t : transporter; citrate:succinate antiporter complement(632265..633728) Escherichia coli ED1a 7141430 YP_002396649.1 CDS citG NC_011745.1 633779 634657 R catalyzes the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA from ATP and 3-dephospho-CoA; triphosphoribosyl-dephospho-CoA synthase complement(633779..634657) Escherichia coli ED1a 7139366 YP_002396650.1 CDS citX NC_011745.1 634632 635183 R 2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase; holo-citrate lyase synthase; CitG forms the prosthetic group precursor 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA which is then transferred to apo-ACP by CitX to produce holo-ACP and pyrophosphate; 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo- citrate lyase complement(634632..635183) Escherichia coli ED1a 7139365 YP_002396651.1 CDS citF NC_011745.1 635187 636719 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 84024606, 87214225; Product type e : enzyme; citrate lyase, citrate-ACP transferase subunit alpha complement(635187..636719) Escherichia coli ED1a 7139367 YP_002396652.1 CDS citE NC_011745.1 636730 637638 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 84024606, 87214225; Product type e : enzyme; citrate lyase, citryl-ACP lyase subunit beta complement(636730..637638) Escherichia coli ED1a 7139364 YP_002396653.1 CDS citD NC_011745.1 637635 637931 R acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate; citrate lyase subunit gamma complement(637635..637931) Escherichia coli ED1a 7139363 YP_002396654.1 CDS citC NC_011745.1 637946 639004 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 84024606, 87214225; Product type e : enzyme; citrate lyase synthetase complement(637946..639004) Escherichia coli ED1a 7139362 YP_002396655.1 CDS citA NC_011745.1 639384 641042 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11889485, 21885746, 9701802; Product type r : regulator; sensory histidine kinase in two-component regulatory system with citB 639384..641042 Escherichia coli ED1a 7139361 YP_002396656.1 CDS dpiA NC_011745.1 641011 641691 D regulates the expression of citAB in citrate fermentation; two-component response regulator DpiA 641011..641691 Escherichia coli ED1a 7139359 YP_002396657.1 CDS dcuC NC_011745.1 641732 643117 R responsible for the transport of C4-dicarboxylates during anaerobic growth; C4-dicarboxylate transporter DcuC complement(641732..643117) Escherichia coli ED1a 7139360 YP_002396658.1 CDS pagP NC_011745.1 643704 644264 D catalyzes the transfer of palmitate to lipid A; palmitoyl transferase 643704..644264 Escherichia coli ED1a 7143076 YP_002396659.1 CDS cspE NC_011745.1 644439 644648 D member of the CspA family; constitutively expressed RNA/ssDNA-binding protein; functions in helping cells adapt to low temperature; aids nucleic acid melting; participates in gene regulation; can act as a transcription antiterminator; cold shock protein CspE 644439..644648 Escherichia coli ED1a 7142048 YP_002396660.1 CDS crcB NC_011745.1 644702 645085 R may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB complement(644702..645085) Escherichia coli ED1a 7142072 YP_002396661.1 CDS ybeM NC_011745.1 645403 645966 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative amidase 645403..645966 Escherichia coli ED1a 7142049 YP_002396662.1 CDS tatE NC_011745.1 646095 646298 D TatE; similar to TatA and found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase protein E 646095..646298 Escherichia coli ED1a 7138938 YP_002396663.1 CDS lipA NC_011745.1 646398 647363 R catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase complement(646398..647363) Escherichia coli ED1a 7141516 YP_002396664.1 CDS ECED1_0625 NC_011745.1 647595 647924 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(647595..647924) Escherichia coli ED1a 7141888 YP_002396665.1 CDS lipB NC_011745.1 648183 648824 R lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B complement(648183..648824) Escherichia coli ED1a 7141847 YP_002396666.1 CDS ybeD NC_011745.1 648925 649188 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8444795; hypothetical protein complement(648925..649188) Escherichia coli ED1a 7141889 YP_002396667.1 CDS dacA NC_011745.1 649298 650509 R penicillin-binding protein 5; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; D-alanyl-D-alanine carboxypeptidase fraction A complement(649298..650509) Escherichia coli ED1a 7138936 YP_002396668.1 CDS rlpA NC_011745.1 650649 651737 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88058785, 2644207; Product type lp : lipoprotein; rare lipoprotein A complement(650649..651737) Escherichia coli ED1a 7143052 YP_002396669.1 CDS mrdB NC_011745.1 651748 652860 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89123070, 90036736, 91072213, 3316191; Product type cp : cell process; cell wall shape-determining protein complement(651748..652860) Escherichia coli ED1a 7141422 YP_002396670.1 CDS mrdA NC_011745.1 652863 654764 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86196149, 87030266, 89174517, 2644207; Product type e : enzyme; penicillin-binding protein 2 complement(652863..654764) Escherichia coli ED1a 7139025 YP_002396671.1 CDS ybeA NC_011745.1 654795 655262 R SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase complement(654795..655262) Escherichia coli ED1a 7139024 YP_002396672.1 CDS ybeB NC_011745.1 655266 655583 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(655266..655583) Escherichia coli ED1a 7138934 YP_002396673.1 CDS phpB NC_011745.1 655843 656454 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7929373; Product type pe : putative enzyme; putative phosphatase with phosphoglycerate mutase domain complement(655843..656454) Escherichia coli ED1a 7138935 YP_002396674.1 CDS nadD NC_011745.1 656478 657119 R transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase complement(656478..657119) Escherichia coli ED1a 7144111 YP_002396675.1 CDS holA NC_011745.1 657121 658152 R required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta complement(657121..658152) Escherichia coli ED1a 7140333 YP_002396676.1 CDS rlpB NC_011745.1 658152 658733 R rare lipoprotein B; involved in the assembly of LPS in the outer membrane; LPS-assembly lipoprotein RlpB complement(658152..658733) Escherichia coli ED1a 7139910 YP_002396677.1 CDS leuS NC_011745.1 658748 661330 R leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase complement(658748..661330) Escherichia coli ED1a 7141423 YP_002396678.1 CDS ybeL NC_011745.1 661565 662047 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11373298, 12105207, 3320963, 7567469; hypothetical protein 661565..662047 Escherichia coli ED1a 7141882 YP_002396679.1 CDS rihA NC_011745.1 662092 663027 R Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively; pyrimidine-specific; ribonucleoside hydrolase 1 complement(662092..663027) Escherichia coli ED1a 7138937 YP_002396680.1 CDS gltL NC_011745.1 663145 663870 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11121068; Product type t : transporter; glutamate and aspartate ABC transporter ATP-binding protein complement(663145..663870) Escherichia coli ED1a 7141413 YP_002396681.1 CDS gltK NC_011745.1 663870 664544 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11121068; Product type t : transporter; glutamate and aspartate ABC transporter membrane protein complement(663870..664544) Escherichia coli ED1a 7142984 YP_002396682.1 CDS gltJ NC_011745.1 664544 665284 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11121068; Product type t : transporter; glutamate and aspartate ABC transporter membrane protein complement(664544..665284) Escherichia coli ED1a 7142983 YP_002396683.1 CDS gltI NC_011745.1 665454 666362 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1091636, 1091635, 10493123, 8740179, 10972807; Product type t : transporter; glutamate and aspartate transporter subunit complement(665454..666362) Escherichia coli ED1a 7140745 YP_002396684.1 CDS ECED1_0646 NC_011745.1 666816 668693 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 666816..668693 Escherichia coli ED1a 7142981 YP_002396685.1 CDS ECED1_0647 NC_011745.1 668629 668823 D Evidence 6 : Doubtful CDS; hypothetical protein 668629..668823 Escherichia coli ED1a 7141848 YP_002396686.1 CDS lnt NC_011745.1 668820 670358 R Transfers the fatty acyl group on membrane lipoproteins; apolipoprotein N-acyltransferase complement(668820..670358) Escherichia coli ED1a 7141849 YP_002396687.1 CDS ybeX NC_011745.1 670383 671261 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1779764; Product type pt : putative transporter; putative divalent ion export protein complement(670383..671261) Escherichia coli ED1a 7141899 YP_002396688.1 CDS ybeY NC_011745.1 671351 671818 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16511207; Product type pe : putative enzyme; putative metalloprotease complement(671351..671818) Escherichia coli ED1a 7138939 YP_002396689.1 CDS ybeZ NC_011745.1 671815 672894 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12762842; Product type pe : putative enzyme; putative enzyme with nucleoside triphosphate hydrolase domain complement(671815..672894) Escherichia coli ED1a 7138940 YP_002396690.1 CDS miaB NC_011745.1 673008 674432 R catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase complement(673008..674432) Escherichia coli ED1a 7138941 YP_002396691.1 CDS ubiF NC_011745.1 674578 675753 D catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol; functions in the biosynthesis of ubiquinone or coenzyme Q; 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase 674578..675753 Escherichia coli ED1a 7138980 YP_002396692.1 CDS asnB NC_011745.1 676993 678657 R functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP; asparagine synthetase B complement(676993..678657) Escherichia coli ED1a 7140633 YP_002396693.1 CDS nagD NC_011745.1 678913 679665 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16430214, 89343637; Product type e : enzyme; UMP phosphatase complement(678913..679665) Escherichia coli ED1a 7142646 YP_002396694.1 CDS nagC NC_011745.1 679713 680933 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15066032, 90136533, 91171292, 92114782, 92356048, 2190615, 2668691, 7545108; Product type r : regulator; DNA-binding transcriptional dual regulator, repressor of N-acetylglucosamine complement(679713..680933) Escherichia coli ED1a 7140339 YP_002396695.1 CDS nagA NC_011745.1 680942 682090 R catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate; N-acetylglucosamine-6-phosphate deacetylase complement(680942..682090) Escherichia coli ED1a 7140338 YP_002396696.1 CDS nagB NC_011745.1 682150 682950 R catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate; glucosamine-6-phosphate deaminase complement(682150..682950) Escherichia coli ED1a 7140336 YP_002396697.1 CDS nagE NC_011745.1 683283 685229 D phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system N-acetyl glucosamine specific transporter subunits IIABC 683283..685229 Escherichia coli ED1a 7140337 YP_002396698.1 CDS glnS NC_011745.1 685432 687096 D catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glutaminyl-tRNA synthetase 685432..687096 Escherichia coli ED1a 7140340 YP_002396699.1 CDS ybfM NC_011745.1 687538 688944 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2118530, 9636669; Product type pt : putative transporter; putative outer membrane porin 687538..688944 Escherichia coli ED1a 7142963 YP_002396700.1 CDS ybfN NC_011745.1 688994 689320 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; putative lipoprotein 688994..689320 Escherichia coli ED1a 7138945 YP_002396701.1 CDS fur NC_011745.1 689404 689850 R negatively regulates a number of operons that encode enzymes involved in iron transport; activated by manganese; forms a homodimer; ferric uptake regulator complement(689404..689850) Escherichia coli ED1a 7138946 YP_002396702.1 CDS ECED1_0665 NC_011745.1 689895 690149 D Evidence 6 : Doubtful CDS; hypothetical protein 689895..690149 Escherichia coli ED1a 7143134 YP_002396703.1 CDS fldA NC_011745.1 690139 690669 R An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin FldA complement(690139..690669) Escherichia coli ED1a 7141850 YP_002396704.1 CDS ybfE NC_011745.1 690809 691102 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20223640, 12427949; Product type cp : cell process; LexA regulated protein complement(690809..691102) Escherichia coli ED1a 7144196 YP_002396705.1 CDS ybfF NC_011745.1 691242 692006 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15808744; Product type pe : putative enzyme; hypothetical protein complement(691242..692006) Escherichia coli ED1a 7138943 YP_002396706.1 CDS seqA NC_011745.1 692191 692736 D negative modulator of the initiation of chromosome replication; replication initiation regulator SeqA 692191..692736 Escherichia coli ED1a 7138944 YP_002396707.1 CDS pgm NC_011745.1 692762 694402 D catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase 692762..694402 Escherichia coli ED1a 7141396 YP_002396708.1 CDS potE NC_011745.1 694459 695778 R catalyzes the uptake of putrescine via a proton symport mechanism, as well as the efflux of putrescine by a putrescine/ornithine antiport system; putrescine transporter complement(694459..695778) Escherichia coli ED1a 7144077 YP_002396709.1 CDS speF NC_011745.1 695775 697973 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92041955; Product type e : enzyme; ornithine decarboxylase complement(695775..697973) Escherichia coli ED1a 7139087 YP_002396710.1 CDS kdpE NC_011745.1 698662 699339 R response regulator in two-component regulatory system with KdpD; regulates the kdp operon involved in potassium transport; DNA-binding transcriptional activator KdpE complement(698662..699339) Escherichia coli ED1a 7143828 YP_002396711.1 CDS kdpD NC_011745.1 699336 702020 R sensory histidine kinase in two-component regulatory system with KdpE; signal sensing protein; sensor protein KdpD complement(699336..702020) Escherichia coli ED1a 7142497 YP_002396712.1 CDS kdpC NC_011745.1 702013 702585 R One of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex; potassium-transporting ATPase subunit C complement(702013..702585) Escherichia coli ED1a 7142496 YP_002396713.1 CDS kdpB NC_011745.1 702594 704642 R One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit B complement(702594..704642) Escherichia coli ED1a 7142495 YP_002396714.1 CDS kdpA NC_011745.1 704665 706338 R catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit A complement(704665..706338) Escherichia coli ED1a 7142494 YP_002396715.1 CDS ybfA NC_011745.1 706740 706946 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 706740..706946 Escherichia coli ED1a 7142493 YP_002396716.1 CDS ybgA NC_011745.1 707047 707556 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6325460, 8387990; hypothetical protein 707047..707556 Escherichia coli ED1a 7138942 YP_002396717.1 CDS phr NC_011745.1 707553 708971 D UV-induced DNA repair; converts cyclobutane-type pyrimidine dimers created during exposure to UV ratiation to monomers; light dependent; deoxyribodipyrimidine photolyase 707553..708971 Escherichia coli ED1a 7138947 YP_002396718.1 CDS ybgH NC_011745.1 709013 710494 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15175316; Product type pt : putative transporter; putative transporter complement(709013..710494) Escherichia coli ED1a 7144112 YP_002396719.1 CDS ybgI NC_011745.1 710765 711508 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14519207; putative hydrolase-oxidase 710765..711508 Escherichia coli ED1a 7138951 YP_002396720.1 CDS ybgJ NC_011745.1 711531 712187 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase subunit 711531..712187 Escherichia coli ED1a 7138952 YP_002396721.1 CDS ybgK NC_011745.1 712181 713113 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase subunit 712181..713113 Escherichia coli ED1a 7138953 YP_002396722.1 CDS ybgL NC_011745.1 713103 713837 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1729609; Product type pe : putative enzyme; LamB/YcsF family protein 713103..713837 Escherichia coli ED1a 7138954 YP_002396723.1 CDS nei NC_011745.1 713873 714664 D 5-formyluracil/5-hydroxymethyluracil DNA glycosylase; involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; acts as DNA glycosylase that recognizes and removes damaged bases with a preference for oxidized pyrimidines; has apurinic/apyrimidinic lyase activity; endonuclease VIII 713873..714664 Escherichia coli ED1a 7138955 YP_002396724.1 CDS abrB NC_011745.1 714661 715707 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8002588; Product type ph : phenotype; hypothetical protein complement(714661..715707) Escherichia coli ED1a 7140373 YP_002396725.1 CDS gltA NC_011745.1 716381 717664 R type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase complement(716381..717664) Escherichia coli ED1a 7138956 YP_002396726.1 CDS ECED1_0690 NC_011745.1 717870 718028 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(717870..718028) Escherichia coli ED1a 7142978 YP_002396727.1 CDS sdhC NC_011745.1 718373 718762 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6237244, 89076355, 89123360, 9521736, 99414342, 11259408, 3309132, 6383359, 9822661; Product type m : membrane component; succinate dehydrogenase cytochrome b556 large membrane subunit 718373..718762 Escherichia coli ED1a 7141851 YP_002396728.1 CDS sdhD NC_011745.1 718756 719103 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82124790, 89076355, 9521736, 99414342, 6383359; Product type m : membrane component; succinate dehydrogenase cytochrome b556 small membrane subunit 718756..719103 Escherichia coli ED1a 7141382 YP_002396729.1 CDS sdhA NC_011745.1 719103 720869 D part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 719103..720869 Escherichia coli ED1a 7141383 YP_002396730.1 CDS sdhB NC_011745.1 720885 721601 D part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 720885..721601 Escherichia coli ED1a 7141380 YP_002396731.1 CDS sucA NC_011745.1 722152 724953 D SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 component 722152..724953 Escherichia coli ED1a 7141381 YP_002396732.1 CDS sucB NC_011745.1 724968 726185 D component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA; dihydrolipoamide succinyltransferase 724968..726185 Escherichia coli ED1a 7143863 YP_002396733.1 CDS sucC NC_011745.1 726279 727445 D catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 726279..727445 Escherichia coli ED1a 7143866 YP_002396734.1 CDS sucD NC_011745.1 727445 728314 D Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 727445..728314 Escherichia coli ED1a 7143868 YP_002396735.1 CDS ECED1_0699 NC_011745.1 728554 729669 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 728554..729669 Escherichia coli ED1a 7140151 YP_002396736.1 CDS cydA NC_011745.1 730999 732567 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87299685, 89255232, 91035243, 1689724, 1724280, 2843510, 3138232; Product type c : carrier; cytochrome d terminal oxidase subunit I 730999..732567 Escherichia coli ED1a 7141852 YP_002396737.1 CDS cydB NC_011745.1 732583 733722 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87299685, 89255232, 91035243, 2843510, 3138232; Product type c : carrier; cytochrome d terminal oxidase subunit II 732583..733722 Escherichia coli ED1a 7142098 YP_002396738.1 CDS ybgE NC_011745.1 733850 734143 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 733850..734143 Escherichia coli ED1a 7142099 YP_002396739.1 CDS ybgC NC_011745.1 734293 734697 D catalyzes the hydrolysis of short chain aliphatic acyl-CoA thioesters; physiological role remains unknown; involved in phospholipid metabolism; part of the Tol/Pal system of proteins that are critical for maintaining the integrity of the cell envelope components; acyl-CoA thioester hydrolase YbgC 734293..734697 Escherichia coli ED1a 7138949 YP_002396740.1 CDS tolQ NC_011745.1 734694 735386 D membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolQ 734694..735386 Escherichia coli ED1a 7138948 YP_002396741.1 CDS tolR NC_011745.1 735390 735818 D membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolR 735390..735818 Escherichia coli ED1a 7141569 YP_002396742.1 CDS tolA NC_011745.1 735883 737148 D inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins; cell envelope integrity inner membrane protein TolA 735883..737148 Escherichia coli ED1a 7141570 YP_002396743.1 CDS tolB NC_011745.1 737281 738573 D forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA; translocation protein TolB 737281..738573 Escherichia coli ED1a 7141566 YP_002396744.1 CDS pal NC_011745.1 738608 739129 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11790745, 87133578, 92244043, 99403391, 11173492, 2687247; Product type lp : lipoprotein; peptidoglycan-associated outer membrane lipoprotein 738608..739129 Escherichia coli ED1a 7141567 YP_002396745.1 CDS ybgF NC_011745.1 739139 739930 D periplasmic protein that interacts with TolA; the tol-pal system is probably involved in maintaining cell envelope integrity; tol-pal system protein YbgF 739139..739930 Escherichia coli ED1a 7144038 YP_002396746.1 CDS nadA NC_011745.1 741076 742119 D 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 741076..742119 Escherichia coli ED1a 7140778 YP_002396747.1 CDS pnuC NC_011745.1 742157 742876 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 219824, 90330519; Product type t : transporter; nicotinamide mononucleotide transporter 742157..742876 Escherichia coli ED1a 7140330 YP_002396748.1 CDS zitB NC_011745.1 742873 743814 R involved in zinc efflux across the cytoplasmic membrane; zinc transporter ZitB complement(742873..743814) Escherichia coli ED1a 7139080 YP_002396749.1 CDS ybgS NC_011745.1 743928 744308 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(743928..744308) Escherichia coli ED1a 7143275 YP_002396750.1 CDS aroG NC_011745.1 744620 745672 D catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 744620..745672 Escherichia coli ED1a 7138957 YP_002396751.1 CDS gpmA NC_011745.1 745838 746590 R 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase complement(745838..746590) Escherichia coli ED1a 7142629 YP_002396752.1 CDS galM NC_011745.1 746793 747833 R catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose; aldose 1-epimerase complement(746793..747833) Escherichia coli ED1a 7143012 YP_002396753.1 CDS galK NC_011745.1 747827 748975 R catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase complement(747827..748975) Escherichia coli ED1a 7143151 YP_002396754.1 CDS galT NC_011745.1 748979 750025 R catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P; galactose-1-phosphate uridylyltransferase complement(748979..750025) Escherichia coli ED1a 7143150 YP_002396755.1 CDS galE NC_011745.1 750035 751051 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89274199, 92253563, 92338916, 3022232, 6301942, 8564363, 8611559, 8931134, 9174344, 9271499, 9708982; Product type e : enzyme; UDP-galactose-4-epimerase complement(750035..751051) Escherichia coli ED1a 7143155 YP_002396756.1 CDS modF NC_011745.1 751312 752784 R contains 2 ATP-binding cassettes; involved in the transport of molybdenum; putative molybdenum transport ATP-binding protein ModF complement(751312..752784) Escherichia coli ED1a 7143148 YP_002396757.1 CDS ECED1_0722 NC_011745.1 752712 752858 R Evidence 6 : Doubtful CDS; hypothetical protein complement(752712..752858) Escherichia coli ED1a 7139008 YP_002396758.1 CDS modE NC_011745.1 752852 753640 R represses the modABCD operon and activates the moaABCD and napFDAGHBC operons; DNA-binding transcriptional regulator ModE complement(752852..753640) Escherichia coli ED1a 7141853 YP_002396759.1 CDS ybhT NC_011745.1 753769 753918 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 753769..753918 Escherichia coli ED1a 7139007 YP_002396760.1 CDS modA NC_011745.1 754085 754858 D with ModCB is involved in the high-affinity transport of molybdate; molybdate transporter periplasmic protein 754085..754858 Escherichia coli ED1a 7142662 YP_002396761.1 CDS modB NC_011745.1 754858 755547 D part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE; molybdate ABC transporter permease 754858..755547 Escherichia coli ED1a 7139003 YP_002396762.1 CDS modC NC_011745.1 755550 756608 D Part of the ABC transporter complex modABC involved in molybdenum import; molybdate transporter ATP-binding protein 755550..756608 Escherichia coli ED1a 7139004 YP_002396763.1 CDS ybhA NC_011745.1 756609 757427 R YbhA; catalyzes the dephosphorylation of pyridoxal phosphate, fructose 1,6-bisphosphate, erythrose 4-phosphate and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; phosphotransferase activity observed when using monophosphates as phosphate donor; member of the haloacid dehalogenase-like hydrolases superfamily; phosphotransferase complement(756609..757427) Escherichia coli ED1a 7139005 YP_002396764.1 CDS pgl NC_011745.1 757582 758577 D catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate; 6-phosphogluconolactonase 757582..758577 Escherichia coli ED1a 7138958 YP_002396765.1 CDS ybhH NC_011745.1 759754 760806 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 759754..760806 Escherichia coli ED1a 7138962 YP_002396766.1 CDS ybhI NC_011745.1 760882 762315 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative anion transporter 760882..762315 Escherichia coli ED1a 7138965 YP_002396767.1 CDS ECED1_0734 NC_011745.1 762216 762386 D Evidence 6 : Doubtful CDS; hypothetical protein 762216..762386 Escherichia coli ED1a 7138966 YP_002396768.1 CDS ybhJ NC_011745.1 762498 764759 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11782506; Product type pe : putative enzyme; hypothetical protein 762498..764759 Escherichia coli ED1a 7141854 YP_002396769.1 CDS ybhC NC_011745.1 764900 766183 R outer membrane lipoprotein that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; YbhC localizes to the cellular poles; member of pectinesterase family; putative pectinesterase complement(764900..766183) Escherichia coli ED1a 7138967 YP_002396770.1 CDS ybhB NC_011745.1 766335 766811 R YbhB; similar to rat and human kinase inhibitory proteins; putative kinase inhibitor protein complement(766335..766811) Escherichia coli ED1a 7138960 YP_002396771.1 CDS bioA NC_011745.1 766870 768159 R catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine--8-amino-7-oxononanoate transaminase complement(766870..768159) Escherichia coli ED1a 7138959 YP_002396772.1 CDS bioB NC_011745.1 768246 769286 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11834738, 12475249, 14704425, 14967041, 20250955, 89066784, 94170810, 94190882, 97382445, 11686925; Product type e : enzyme; biotin synthase 768246..769286 Escherichia coli ED1a 7140450 YP_002396773.1 CDS bioF NC_011745.1 769283 770437 D catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 769283..770437 Escherichia coli ED1a 7140451 YP_002396774.1 CDS bioC NC_011745.1 770424 771179 D putative methyltransferase; acyl carrier protein involved in an unidentified step in the synthesis of pimeloyl-CoA, a biotin precursor; member of the bio operon (bioABFCD); in Escherichia coli, bioC-null mutants require biotin for growth; biotin biosynthesis protein BioC 770424..771179 Escherichia coli ED1a 7140454 YP_002396775.1 CDS bioD NC_011745.1 771172 771849 D DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 771172..771849 Escherichia coli ED1a 7140452 YP_002396776.1 CDS uvrB NC_011745.1 772428 774449 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 772428..774449 Escherichia coli ED1a 7140453 YP_002396777.1 CDS ybhK NC_011745.1 774487 775395 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16272399; Product type pe : putative enzyme; putative transferase complement(774487..775395) Escherichia coli ED1a 7139151 YP_002396778.1 CDS ECED1_0745 NC_011745.1 775638 775793 R Evidence 6 : Doubtful CDS; hypothetical protein complement(775638..775793) Escherichia coli ED1a 7138968 YP_002396779.1 CDS moaA NC_011745.1 775792 776781 D together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; molybdenum cofactor biosynthesis protein A 775792..776781 Escherichia coli ED1a 7141855 YP_002396780.1 CDS moaB NC_011745.1 776803 777315 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93368423; Product type pf : putative factor; molybdopterin biosynthesis protein B 776803..777315 Escherichia coli ED1a 7138996 YP_002396781.1 CDS moaC NC_011745.1 777318 777803 D MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC 777318..777803 Escherichia coli ED1a 7138997 YP_002396782.1 CDS moaD NC_011745.1 777796 778041 D catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin synthase small subunit 777796..778041 Escherichia coli ED1a 7138998 YP_002396783.1 CDS moaE NC_011745.1 778043 778495 D catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin guanine dinucleotide biosynthesis protein MoaE 778043..778495 Escherichia coli ED1a 7138999 YP_002396784.1 CDS ybhL NC_011745.1 778632 779336 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 778632..779336 Escherichia coli ED1a 7139000 YP_002396785.1 CDS ybhM NC_011745.1 779542 780255 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 779542..780255 Escherichia coli ED1a 7138969 YP_002396786.1 CDS ybhN NC_011745.1 780291 781247 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(780291..781247) Escherichia coli ED1a 7138970 YP_002396787.1 CDS ybhO NC_011745.1 781247 782488 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20102623, 10634942; Product type e : enzyme; cardiolipin synthase 2 complement(781247..782488) Escherichia coli ED1a 7138971 YP_002396788.1 CDS ybhP NC_011745.1 782485 783246 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative metal-dependent hydrolase complement(782485..783246) Escherichia coli ED1a 7138972 YP_002396789.1 CDS ybhQ NC_011745.1 783379 783789 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 783379..783789 Escherichia coli ED1a 7138973 YP_002396790.1 CDS ybhR NC_011745.1 783751 784857 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter permease complement(783751..784857) Escherichia coli ED1a 7138974 YP_002396791.1 CDS ybhS NC_011745.1 784868 786001 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter permease complement(784868..786001) Escherichia coli ED1a 7138975 YP_002396792.1 CDS ybhF NC_011745.1 785994 787730 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATP-binding protein complement(785994..787730) Escherichia coli ED1a 7139222 YP_002396793.1 CDS ybhG NC_011745.1 787723 788721 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16092522; Product type pt : putative transporter; hypothetical protein complement(787723..788721) Escherichia coli ED1a 7138963 YP_002396794.1 CDS ybiH NC_011745.1 788721 789392 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(788721..789392) Escherichia coli ED1a 7138964 YP_002396795.1 CDS rhlE NC_011745.1 789621 790982 D this helicase is not essential cell growth; ATP-dependent RNA helicase RhlE 789621..790982 Escherichia coli ED1a 7142666 YP_002396796.1 CDS ybiA NC_011745.1 791215 791520 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(791215..791520) Escherichia coli ED1a 7141614 YP_002396797.1 CDS dinG NC_011745.1 791519 793669 D helicase involved in DNA repair and perhaps also replication; ATP-dependent DNA helicase DinG 791519..793669 Escherichia coli ED1a 7142663 YP_002396798.1 CDS ybiB NC_011745.1 793697 794659 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; glycosyl transferase family protein 793697..794659 Escherichia coli ED1a 7140490 YP_002396799.1 CDS ybiC NC_011745.1 794800 795885 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8405966; Product type pe : putative enzyme; hypothetical protein 794800..795885 Escherichia coli ED1a 7142664 YP_002396800.1 CDS ybiJ NC_011745.1 796114 796374 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(796114..796374) Escherichia coli ED1a 7142665 YP_002396801.1 CDS ybiI NC_011745.1 796639 796905 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(796639..796905) Escherichia coli ED1a 7142668 YP_002396802.1 CDS ybiX NC_011745.1 796979 797656 R Evidence 4 : Homologs of previously reported genes of unknown function; putative hydroxylase complement(796979..797656) Escherichia coli ED1a 7142667 YP_002396803.1 CDS fiu NC_011745.1 797872 800154 R Fiu; YbiL; porin involved in the uptake of iron complexed with catecholate siderophores (e.g. dihydroxybenzoylserine, dihydroxybenzoate) and beta lactam agents; Fiu interacts with TonB which provides the energy required for transport across the outer membrane; acts as a receptor for iron-siderophores and microcins E492, M, and H47; outer membrane protein; catecholate siderophore receptor Fiu complement(797872..800154) Escherichia coli ED1a 7142678 YP_002396804.1 CDS ybiM NC_011745.1 800419 800823 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(800419..800823) Escherichia coli ED1a 7144188 YP_002396805.1 CDS ybiN NC_011745.1 800955 801881 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative SAM-dependent methyltransferase 800955..801881 Escherichia coli ED1a 7142669 YP_002396806.1 CDS ybiO NC_011745.1 801878 804103 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein complement(801878..804103) Escherichia coli ED1a 7142670 YP_002396807.1 CDS glnQ NC_011745.1 804220 804942 R similar to ATP-binding component of ABC transporters; glutamine ABC transporter ATP-binding protein complement(804220..804942) Escherichia coli ED1a 7142671 YP_002396808.1 CDS glnP NC_011745.1 804939 805598 R similar to permease component of ABC transporters; mutations impair ability of Escherichia coli to transport and utilize glutamine; glutamine ABC transporter permease complement(804939..805598) Escherichia coli ED1a 7142962 YP_002396809.1 CDS glnH NC_011745.1 805737 806483 R similar to periplasmic-binding component of ABC transporters; glutamine ABC transporter periplasmic protein complement(805737..806483) Escherichia coli ED1a 7142961 YP_002396810.1 CDS dps NC_011745.1 806887 807390 R binds DNA in a non-sequence-specific manner and is abundant during stationary phase; forms a DNA-protein crystal that protects DNA from damage; required for normal starvation response and long-term stationary viability; forms a homododecameric complex and sequesters iron which provides protection against oxidative damage; DNA starvation/stationary phase protection protein Dps complement(806887..807390) Escherichia coli ED1a 7142958 YP_002396811.1 CDS ompX NC_011745.1 808930 809445 D OmpX; involved in cell adhesion; forms an eight-stranded antiparallel beta-barrel that protrudes from the cell surface; mutations in the gene increase cell-surface contact in fimbriated strains but decrease contact in nonfimbriated strains; outer membrane protein X 808930..809445 Escherichia coli ED1a 7141618 YP_002396812.1 CDS ybiP NC_011745.1 809495 811078 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16514146; Product type pe : putative enzyme; hypothetical protein complement(809495..811078) Escherichia coli ED1a 7139977 YP_002396813.1 CDS mntR NC_011745.1 811664 812131 D Transcriptional regulator that represses the manganese transporter MntH when manganese is present; manganese transport regulator MntR 811664..812131 Escherichia coli ED1a 7140149 YP_002396814.1 CDS ybiR NC_011745.1 812128 813246 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 812128..813246 Escherichia coli ED1a 7138995 YP_002396815.1 CDS ybiS NC_011745.1 813304 814224 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10493123, 9298646; hypothetical protein complement(813304..814224) Escherichia coli ED1a 7142673 YP_002396816.1 CDS ybiT NC_011745.1 814443 816035 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11916677; Product type pt : putative transporter; putative ABC transporter ATP-binding protein 814443..816035 Escherichia coli ED1a 7142674 YP_002396817.1 CDS ybiV NC_011745.1 816235 817050 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15657928; Product type e : enzyme; type II HAD phosphatase complement(816235..817050) Escherichia coli ED1a 7142675 YP_002396818.1 CDS ybiW NC_011745.1 817196 819628 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16218870; Product type pe : putative enzyme; putative glycyl radical cofactor protein complement(817196..819628) Escherichia coli ED1a 7142676 YP_002396819.1 CDS ybiY NC_011745.1 819634 820560 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15581584; Product type pe : putative enzyme; putative AdoMet-dependent glycyl radical activating enzyme complement(819634..820560) Escherichia coli ED1a 7142677 YP_002396820.1 CDS fsaA NC_011745.1 820664 821326 D similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 820664..821326 Escherichia coli ED1a 7142679 YP_002396821.1 CDS moeB NC_011745.1 821402 822151 R ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase; molybdopterin biosynthesis protein MoeB complement(821402..822151) Escherichia coli ED1a 7142184 YP_002396822.1 CDS moeA NC_011745.1 822151 823386 R is involved in the formation of active molybdenum cofactor and the chelation of molybdenum; molybdopterin biosynthesis protein MoeA complement(822151..823386) Escherichia coli ED1a 7139010 YP_002396823.1 CDS iaaA NC_011745.1 823590 824555 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15159592, 20508248, 3045084, 7984428; Product type e : enzyme; L-asparaginase 823590..824555 Escherichia coli ED1a 7139009 YP_002396824.1 CDS yliA NC_011745.1 824575 826413 D with GsiBCD is involved in glutathione import; GsiA contains 2 ATP-binding domains; glutathione transporter ATP-binding protein 824575..826413 Escherichia coli ED1a 7140213 YP_002396825.1 CDS yliB NC_011745.1 826433 827971 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 17366475; Product type pt : putative transporter; putative peptide ABC transporter periplasmic-binding protein 826433..827971 Escherichia coli ED1a 7140962 YP_002396826.1 CDS yliC NC_011745.1 827989 828909 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative peptide ABC transporter permease 827989..828909 Escherichia coli ED1a 7140963 YP_002396827.1 CDS yliD NC_011745.1 828912 829823 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative peptide ABC transporter permease 828912..829823 Escherichia coli ED1a 7140964 YP_002396828.1 CDS yliE NC_011745.1 830000 832348 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 830000..832348 Escherichia coli ED1a 7140965 YP_002396829.1 CDS yliF NC_011745.1 832356 833684 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15380559; Product type pe : putative enzyme; putative diguanylate cyclase 832356..833684 Escherichia coli ED1a 7140966 YP_002396830.1 CDS rimO NC_011745.1 833731 835056 R catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit; ribosomal protein S12 methylthiotransferase complement(833731..835056) Escherichia coli ED1a 7140967 YP_002396831.1 CDS bssR NC_011745.1 835269 835652 D BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing; biofilm formation regulatory protein BssR 835269..835652 Escherichia coli ED1a 7140968 YP_002396832.1 CDS yliI NC_011745.1 835763 836878 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16522795, 16864586; Product type e : enzyme; PQQ-dependent aldose sugar dehydrogenase (asd) 835763..836878 Escherichia coli ED1a 7140463 YP_002396833.1 CDS yliJ NC_011745.1 836875 837501 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glutathione S-transferase complement(836875..837501) Escherichia coli ED1a 7140969 YP_002396834.1 CDS dacC NC_011745.1 837748 838950 D penicillin-binding protein 6a; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase fraction C 837748..838950 Escherichia coli ED1a 7140970 YP_002396835.1 CDS deoR NC_011745.1 838997 839755 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89231635, 89336786, 92231401, 2994018; Product type r : regulator; DNA-binding transcriptional repressor DeoR complement(838997..839755) Escherichia coli ED1a 7143054 YP_002396836.1 CDS ybjG NC_011745.1 839813 840409 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15778224; Product type e : enzyme; undecaprenyl pyrophosphate phosphatase complement(839813..840409) Escherichia coli ED1a 7143097 YP_002396837.1 CDS cmr NC_011745.1 840694 841926 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10022825, 12578981, 14688269, 21217867, 21450803, 9079913, 9644262, 99030337, 8655497; Product type t : transporter; multidrug efflux system protein 840694..841926 Escherichia coli ED1a 7142683 YP_002396838.1 CDS ybjH NC_011745.1 841967 842251 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(841967..842251) Escherichia coli ED1a 7139381 YP_002396839.1 CDS ybjI NC_011745.1 842337 843125 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15808744; Product type pe : putative enzyme; putative phosphatase complement(842337..843125) Escherichia coli ED1a 7142684 YP_002396840.1 CDS ybjJ NC_011745.1 843141 844349 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter complement(843141..844349) Escherichia coli ED1a 7142685 YP_002396841.1 CDS ybjK NC_011745.1 844433 844969 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 844433..844969 Escherichia coli ED1a 7142686 YP_002396842.1 CDS ybjL NC_011745.1 845144 846829 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; hypothetical protein complement(845144..846829) Escherichia coli ED1a 7140746 YP_002396843.1 CDS ybjM NC_011745.1 847099 847476 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 847099..847476 Escherichia coli ED1a 7142688 YP_002396844.1 CDS grxA NC_011745.1 847506 847763 R functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase; glutaredoxin 1 complement(847506..847763) Escherichia coli ED1a 7142689 YP_002396845.1 CDS ybjC NC_011745.1 847923 848210 D YbjC; located in the same operon as the nfsA gene; member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress; induced by paraquat; regulated by SoxS; unknown function; hypothetical protein 847923..848210 Escherichia coli ED1a 7143024 YP_002396846.1 CDS nfsA NC_011745.1 848194 848916 D NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds; nitroreductase A 848194..848916 Escherichia coli ED1a 7142680 YP_002396847.1 CDS rimK NC_011745.1 848977 849879 D responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6; ribosomal protein S6 modification protein 848977..849879 Escherichia coli ED1a 7140381 YP_002396848.1 CDS ybjN NC_011745.1 849967 850443 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 849967..850443 Escherichia coli ED1a 7141418 YP_002396849.1 CDS potF NC_011745.1 850792 851904 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93106992, 9651355, 9298646, 8416922; Product type t : transporter; putrescine ABC transporter periplasmic-binding protein 850792..851904 Escherichia coli ED1a 7142690 YP_002396850.1 CDS potG NC_011745.1 851999 853132 D part of the PotFGHI ATP-dependent putrescine transporter; putrescine transporter ATP-binding subunit 851999..853132 Escherichia coli ED1a 7139088 YP_002396851.1 CDS potI NC_011745.1 854082 854927 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93106992; Product type t : transporter; putrescine ABC transporter membrane protein 854082..854927 Escherichia coli ED1a 7139091 YP_002396852.1 CDS ybjO NC_011745.1 854987 855475 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 854987..855475 Escherichia coli ED1a 7139092 YP_002396853.1 CDS rumB NC_011745.1 855516 856643 D RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA; 23S rRNA methyluridine methyltransferase 855516..856643 Escherichia coli ED1a 7142691 YP_002396854.1 CDS artJ NC_011745.1 856672 857403 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93273744, 9298646, 9600841, 8801422; Product type t : transporter; arginine ABC transporter subunit periplasmic-binding protein complement(856672..857403) Escherichia coli ED1a 7140136 YP_002396855.1 CDS artM NC_011745.1 857629 858297 R with ArtPQJI acts to transport arginine across the inner membrane; arginine transporter permease subunit ArtM complement(857629..858297) Escherichia coli ED1a 7142637 YP_002396856.1 CDS artQ NC_011745.1 858297 859013 R with ArtPMJI transports arginine across the inner membrane; arginine transporter permease subunit ArtQ complement(858297..859013) Escherichia coli ED1a 7142638 YP_002396857.1 CDS artI NC_011745.1 859020 859751 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93273744, 9298646, 9600841, 8801422, 9740056; Product type t : transporter; arginine ABC transporter subunit periplasmic-binding protein complement(859020..859751) Escherichia coli ED1a 7142640 YP_002396858.1 CDS artP NC_011745.1 859769 860497 R With ArtMQJI transports arginine across the inner membrane; arginine transporter ATP-binding subunit complement(859769..860497) Escherichia coli ED1a 7142636 YP_002396859.1 CDS ybjP NC_011745.1 860715 861230 R induced during stationary phase and by acivicin (a glutamine analog); regulated by Lrp and RpoS; putative lipoprotein complement(860715..861230) Escherichia coli ED1a 7142639 YP_002396860.1 CDS ybjQ NC_011745.1 861356 861679 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 861356..861679 Escherichia coli ED1a 7142692 YP_002396861.1 CDS ybjR NC_011745.1 861676 862506 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative cell wall amidase and lipoprotein 861676..862506 Escherichia coli ED1a 7142693 YP_002396862.1 CDS ybjS NC_011745.1 862503 863516 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative NAD(P)H-binding oxidoreductase with NAD(P)-binding Rossmann-fold domain complement(862503..863516) Escherichia coli ED1a 7142694 YP_002396863.1 CDS ybjT NC_011745.1 863615 865045 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(863615..865045) Escherichia coli ED1a 7142695 YP_002396864.1 CDS ltaE NC_011745.1 865056 866057 R low- specificity; catalyzes the formation of acetaldehyde and glycine from L-threonine; acts on L-threonine, L-allo-threonine, L-threo-phenylserine, and L-erythro-phenylserine; L-threonine aldolase complement(865056..866057) Escherichia coli ED1a 7142696 YP_002396865.1 CDS poxB NC_011745.1 866094 867812 R catalyzes the formation of acetate from pyruvate; pyruvate dehydrogenase complement(866094..867812) Escherichia coli ED1a 7141928 YP_002396866.1 CDS hcr NC_011745.1 867945 868913 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20117674; Product type e : enzyme; HCP oxidoreductase, NADH-dependent complement(867945..868913) Escherichia coli ED1a 7139094 YP_002396867.1 CDS hcp NC_011745.1 868925 870577 R catalyzes the reduction of hydroxylamine to ammonia and water; hydroxylamine reductase complement(868925..870577) Escherichia coli ED1a 7139857 YP_002396868.1 CDS ybjE NC_011745.1 870721 871620 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter complement(870721..871620) Escherichia coli ED1a 7139856 YP_002396869.1 CDS aqpZ NC_011745.1 872115 872810 R porin involved in osmoregulation allowing water to move into and out of the cell in response to osmotic pressure; aquaporin Z complement(872115..872810) Escherichia coli ED1a 7142682 YP_002396870.1 CDS ybjD NC_011745.1 873236 874894 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 873236..874894 Escherichia coli ED1a 7142595 YP_002396871.1 CDS ybjX NC_011745.1 874891 875883 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(874891..875883) Escherichia coli ED1a 7142681 YP_002396872.1 CDS macA NC_011745.1 875998 877113 D confers macrolide resistance via active drug efflux; macrolide transporter subunit MacA 875998..877113 Escherichia coli ED1a 7142697 YP_002396873.1 CDS macB NC_011745.1 877110 879056 D with MacA is involved in the export of macrolide; macrolide transporter ATP-binding /permease 877110..879056 Escherichia coli ED1a 7141940 YP_002396874.1 CDS cspD NC_011745.1 879129 879353 R inhibits DNA replication at both initiation and elongation steps; stationary phase and starvation inducible; stationary phase/starvation inducible regulatory protein CspD complement(879129..879353) Escherichia coli ED1a 7141941 YP_002396875.1 CDS clpS NC_011745.1 879676 879996 D involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA; ATP-dependent Clp protease adaptor protein ClpS 879676..879996 Escherichia coli ED1a 7142071 YP_002396876.1 CDS clpA NC_011745.1 880027 882303 D ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease; directs protease to specific substrates; ATP-dependent Clp protease ATP-binding subunit 880027..882303 Escherichia coli ED1a 7139377 YP_002396877.1 CDS ECED1_0850 NC_011745.1 883720 884709 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 883720..884709 Escherichia coli ED1a 7139374 YP_002396878.1 CDS ECED1_0851 NC_011745.1 884706 887939 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative CRISPR-associated helicase 884706..887939 Escherichia coli ED1a 7141856 YP_002396879.1 CDS ECED1_0852 NC_011745.1 888269 889576 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 888269..889576 Escherichia coli ED1a 7141857 YP_002396880.1 CDS ECED1_0853 NC_011745.1 889573 890496 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 889573..890496 Escherichia coli ED1a 7141858 YP_002396881.1 CDS ECED1_0854 NC_011745.1 890507 891508 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 890507..891508 Escherichia coli ED1a 7141859 YP_002396882.1 CDS ECED1_0855 NC_011745.1 891477 892073 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 891477..892073 Escherichia coli ED1a 7141860 YP_002396883.1 CDS ECED1_0857 NC_011745.1 892677 892970 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(892677..892970) Escherichia coli ED1a 7140632 YP_002396884.1 CDS infA NC_011745.1 893537 893755 R stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 complement(893537..893755) Escherichia coli ED1a 7141862 YP_002396885.1 CDS aat NC_011745.1 894040 894744 R leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys; leucyl/phenylalanyl-tRNA--protein transferase complement(894040..894744) Escherichia coli ED1a 7141109 YP_002396886.1 CDS cydC NC_011745.1 894786 896507 R in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein complement(894786..896507) Escherichia coli ED1a 7143630 YP_002396887.1 CDS cydD NC_011745.1 896508 898274 R in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein complement(896508..898274) Escherichia coli ED1a 7142100 YP_002396888.1 CDS trxB NC_011745.1 898397 899362 R catalyzes the transfer of electrons from NADPH to thioredoxin; FAD/NAD(P) binding; thioredoxin reductase complement(898397..899362) Escherichia coli ED1a 7142101 YP_002396889.1 CDS lrp NC_011745.1 899906 900400 D mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system; leucine-responsive transcriptional regulator 899906..900400 Escherichia coli ED1a 7140832 YP_002396890.1 CDS ftsK NC_011745.1 900535 904602 D DNA-binding membrane protein required for chromosome resolution and partitioning; DNA translocase FtsK 900535..904602 Escherichia coli ED1a 7141926 YP_002396891.1 CDS lolA NC_011745.1 904758 905372 D participates with LolB in the incorporation of lipoprotein into the outer membrane; outer-membrane lipoprotein carrier protein 904758..905372 Escherichia coli ED1a 7142193 YP_002396892.1 CDS ycaJ NC_011745.1 905383 906726 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7567469, 7628437, 11459952, 11029431; Product type cp : cell process; recombination factor protein RarA 905383..906726 Escherichia coli ED1a 7141900 YP_002396893.1 CDS serS NC_011745.1 906817 908109 D catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 906817..908109 Escherichia coli ED1a 7142702 YP_002396894.1 CDS ECED1_0868 NC_011745.1 909097 909399 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative transcriptional activator from prophage complement(909097..909399) Escherichia coli ED1a 7141400 YP_002396895.1 CDS D NC_011745.1 909444 910568 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; late control gene D protein from prophage complement(909444..910568) Escherichia coli ED1a 7141863 YP_002396896.1 CDS FI NC_011745.1 910723 911910 D Evidence 2b : Function of strongly homologous gene; PubMedId : 1825255; Product type h : extrachromosomal origin; major tail sheath protein FI from bacteriophage 910723..911910 Escherichia coli ED1a 7143050 YP_002396897.1 CDS FII NC_011745.1 911910 912419 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; major tail sheath protein FII from prophage 911910..912419 Escherichia coli ED1a 7144175 YP_002396898.1 CDS ECED1_0872 NC_011745.1 912467 912856 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage tail protein 912467..912856 Escherichia coli ED1a 7144179 YP_002396899.1 CDS ECED1_0873 NC_011745.1 912968 915796 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative tail protein from prophage; putative tail length tape measure motif 912968..915796 Escherichia coli ED1a 7140939 YP_002396900.1 CDS ECED1_0874 NC_011745.1 915762 916298 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative tail protein 915762..916298 Escherichia coli ED1a 7141021 YP_002396901.1 CDS ECED1_0875 NC_011745.1 916309 916896 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(916309..916896) Escherichia coli ED1a 7141022 YP_002396902.1 CDS ECED1_0877 NC_011745.1 916908 918248 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage tail fiber protein complement(916908..918248) Escherichia coli ED1a 7141023 YP_002396903.1 CDS I NC_011745.1 918248 918880 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail protein I (GpI) from prophage complement(918248..918880) Escherichia coli ED1a 7141024 YP_002396904.1 CDS J NC_011745.1 918864 919760 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Baseplate assembly protein GpJ from prophage complement(918864..919760) Escherichia coli ED1a 7140211 YP_002396905.1 CDS W NC_011745.1 919747 920112 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Baseplate assembly protein GpW from prophage complement(919747..920112) Escherichia coli ED1a 7142478 YP_002396906.1 CDS V NC_011745.1 920109 920705 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Baseplate assembly protein GpV from prophage complement(920109..920705) Escherichia coli ED1a 7139169 YP_002396907.1 CDS ECED1_0882 NC_011745.1 920687 921433 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage tail completion protein S complement(920687..921433) Escherichia coli ED1a 7139161 YP_002396908.1 CDS R NC_011745.1 921315 921782 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; phage tail completion protein R complement(921315..921782) Escherichia coli ED1a 7141025 YP_002396909.1 CDS ECED1_0884 NC_011745.1 921795 921968 D Evidence 6 : Doubtful CDS; hypothetical protein 921795..921968 Escherichia coli ED1a 7141247 YP_002396910.1 CDS ECED1_0885 NC_011745.1 922118 924184 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(922118..924184) Escherichia coli ED1a 7141026 YP_002396911.1 CDS ECED1_0886 NC_011745.1 924174 924503 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(924174..924503) Escherichia coli ED1a 7141027 YP_002396912.1 CDS ECED1_0887 NC_011745.1 924292 924744 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(924292..924744) Escherichia coli ED1a 7141028 YP_002396913.1 CDS lys NC_011745.1 924714 925265 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; prophage lysozyme complement(924714..925265) Escherichia coli ED1a 7141029 YP_002396914.1 CDS ECED1_0889 NC_011745.1 925243 925539 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(925243..925539) Escherichia coli ED1a 7141930 YP_002396915.1 CDS X NC_011745.1 925530 925799 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail protein X from prophage complement(925530..925799) Escherichia coli ED1a 7141030 YP_002396916.1 CDS ECED1_0891 NC_011745.1 925730 926224 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage head completion protein L complement(925730..926224) Escherichia coli ED1a 7139197 YP_002396917.1 CDS ECED1_0892 NC_011745.1 926329 927126 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage terminase (endonuclease subunit) complement(926329..927126) Escherichia coli ED1a 7141031 YP_002396918.1 CDS N NC_011745.1 927167 928267 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; capsid proteins (GpN) complement(927167..928267) Escherichia coli ED1a 7141032 YP_002396919.1 CDS ECED1_0894 NC_011745.1 928285 929154 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative capsid scaffolding protein (GpO) complement(928285..929154) Escherichia coli ED1a 7140326 YP_002396920.1 CDS P NC_011745.1 929172 931010 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; terminase, ATPase subunit (GpP) 929172..931010 Escherichia coli ED1a 7141033 YP_002396921.1 CDS ECED1_0896 NC_011745.1 931132 932058 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative portal vertex protein (GpQ) from prophage 931132..932058 Escherichia coli ED1a 7139996 YP_002396922.1 CDS ECED1_0897 NC_011745.1 932124 932627 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(932124..932627) Escherichia coli ED1a 7141034 YP_002396923.1 CDS ECED1_0898 NC_011745.1 932733 932906 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(932733..932906) Escherichia coli ED1a 7141035 YP_002396924.1 CDS ECED1_0899 NC_011745.1 933759 933941 R Evidence 7 : Gene remnant; Product type h : extrachromosomal origin; Single-stranded DNA-binding protein (fragment) complement(933759..933941) Escherichia coli ED1a 7141036 YP_002396925.1 CDS insM NC_011745.1 934069 934371 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS600 934069..934371 Escherichia coli ED1a 7141037 YP_002396926.1 CDS ECED1_0901 NC_011745.1 934407 935225 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS600 934407..935225 Escherichia coli ED1a 7141163 YP_002396927.1 CDS ren NC_011745.1 935376 935783 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Protein ren (modular protein) from prophage complement(935376..935783) Escherichia coli ED1a 7141038 YP_002396928.1 CDS ECED1_0903 NC_011745.1 935711 935920 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(935711..935920) Escherichia coli ED1a 7141588 YP_002396929.1 CDS ECED1_0904 NC_011745.1 935930 936334 R Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein complement(935930..936334) Escherichia coli ED1a 7141039 YP_002396930.1 CDS ECED1_0905 NC_011745.1 936331 938853 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative endonuclease from prophage, replication protein A (GpA) complement(936331..938853) Escherichia coli ED1a 7141040 YP_002396931.1 CDS ECED1_0906 NC_011745.1 938841 939257 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(938841..939257) Escherichia coli ED1a 7141041 YP_002396932.1 CDS ECED1_0907 NC_011745.1 939326 939547 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(939326..939547) Escherichia coli ED1a 7141042 YP_002396933.1 CDS ECED1_0908 NC_011745.1 939748 940395 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 939748..940395 Escherichia coli ED1a 7141043 YP_002396934.1 CDS ECED1_0909 NC_011745.1 940369 940719 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(940369..940719) Escherichia coli ED1a 7141044 YP_002396935.1 CDS ECED1_0910 NC_011745.1 940710 940928 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(940710..940928) Escherichia coli ED1a 7141045 YP_002396936.1 CDS ECED1_0911 NC_011745.1 940925 941161 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(940925..941161) Escherichia coli ED1a 7141046 YP_002396937.1 CDS dam NC_011745.1 941197 942177 R Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; DNA adenine methylase from prophage complement(941197..942177) Escherichia coli ED1a 7141047 YP_002396938.1 CDS ECED1_0913 NC_011745.1 942193 942381 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(942193..942381) Escherichia coli ED1a 7143058 YP_002396939.1 CDS ECED1_0914 NC_011745.1 942411 943001 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative ribonuclease (polynucleotidyl transferase) from prophage complement(942411..943001) Escherichia coli ED1a 7141048 YP_002396940.1 CDS ECED1_0915 NC_011745.1 942992 943264 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(942992..943264) Escherichia coli ED1a 7141049 YP_002396941.1 CDS ECED1_0916 NC_011745.1 943559 943801 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(943559..943801) Escherichia coli ED1a 7141050 YP_002396942.1 CDS ECED1_0917 NC_011745.1 943976 944143 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 943976..944143 Escherichia coli ED1a 7141051 YP_002396943.1 CDS ECED1_0918 NC_011745.1 944317 944694 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(944317..944694) Escherichia coli ED1a 7141052 YP_002396944.1 CDS ECED1_0919 NC_011745.1 944581 945036 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 944581..945036 Escherichia coli ED1a 7141053 YP_002396945.1 CDS ECED1_0920 NC_011745.1 945018 945362 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(945018..945362) Escherichia coli ED1a 7141054 YP_002396946.1 CDS ECED1_0921 NC_011745.1 945121 945645 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(945121..945645) Escherichia coli ED1a 7141055 YP_002396947.1 CDS C NC_011745.1 945608 946090 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; repressor protein C (modular protein) from prophage 945608..946090 Escherichia coli ED1a 7141056 YP_002396948.1 CDS int NC_011745.1 946145 947152 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Integrase 946145..947152 Escherichia coli ED1a 7140470 YP_002396949.1 CDS dmsA NC_011745.1 947452 949896 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91008971, 92011349, 94171715, 10801884, 3062312; Product type e : enzyme; dimethyl sulfoxide reductase, anaerobic subunit A 947452..949896 Escherichia coli ED1a 7141172 YP_002396950.1 CDS dmsB NC_011745.1 949907 950524 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91070067, 91355180, 92011349, 3062312; Product type e : enzyme; dimethyl sulfoxide reductase, anaerobic subunit B 949907..950524 Escherichia coli ED1a 7140498 YP_002396951.1 CDS dmsC NC_011745.1 950526 951389 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91008971, 92011349, 3062312, 8429002; Product type e : enzyme; dimethyl sulfoxide reductase, anaerobic subunit C 950526..951389 Escherichia coli ED1a 7140499 YP_002396952.1 CDS ycaC NC_011745.1 951425 952051 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9782055, 3062312, 11714269; Product type pe : putative enzyme; putative hydrolase complement(951425..952051) Escherichia coli ED1a 7140500 YP_002396953.1 CDS ycaD NC_011745.1 952365 953513 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS family transporter protein 952365..953513 Escherichia coli ED1a 7142699 YP_002396954.1 CDS pflA NC_011745.1 953610 954350 R activates pyruvate formate-lyase 1 under anaerobic conditions; pyruvate formate lyase-activating enzyme 1 complement(953610..954350) Escherichia coli ED1a 7142700 YP_002396955.1 CDS pflB NC_011745.1 954542 956824 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91064082, 92276323, 10504733, 1310545, 2651404, 3053170, 9629924; Product type e : enzyme; pyruvate formate lyase I complement(954542..956824) Escherichia coli ED1a 7144069 YP_002396956.1 CDS focA NC_011745.1 956879 957736 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94293770, 2651404; Product type t : transporter; formate transporter complement(956879..957736) Escherichia coli ED1a 7144070 YP_002396957.1 CDS ycaO NC_011745.1 958142 959902 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(958142..959902) Escherichia coli ED1a 7142154 YP_002396958.1 CDS ycaP NC_011745.1 960032 960724 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 960032..960724 Escherichia coli ED1a 7142704 YP_002396959.1 CDS serC NC_011745.1 960923 962011 D catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase 960923..962011 Escherichia coli ED1a 7142705 YP_002396960.1 CDS aroA NC_011745.1 962082 963365 D catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 962082..963365 Escherichia coli ED1a 7141399 YP_002396961.1 CDS ycaL NC_011745.1 963535 964299 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative lipoprotein with metallohydrolase domain 963535..964299 Escherichia coli ED1a 7142623 YP_002396962.1 CDS cmk NC_011745.1 964472 965155 D Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 964472..965155 Escherichia coli ED1a 7142703 YP_002396963.1 CDS rpsA NC_011745.1 965266 966939 D in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 965266..966939 Escherichia coli ED1a 7139380 YP_002396964.1 CDS ihfB NC_011745.1 967099 967383 D This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit beta 967099..967383 Escherichia coli ED1a 7140084 YP_002396965.1 CDS ycaI NC_011745.1 967589 969853 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 967589..969853 Escherichia coli ED1a 7140233 YP_002396966.1 CDS msbA NC_011745.1 969890 971638 D involved in the transport of lipid A across the inner membrane; lipid transporter ATP-binding/permease 969890..971638 Escherichia coli ED1a 7142701 YP_002396967.1 CDS lpxK NC_011745.1 971635 972621 D transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate; tetraacyldisaccharide 4'-kinase 971635..972621 Escherichia coli ED1a 7139030 YP_002396968.1 CDS ycaQ NC_011745.1 972658 973764 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 972658..973764 Escherichia coli ED1a 7141922 YP_002396969.1 CDS ECED1_0944 NC_011745.1 973761 974579 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS600 complement(973761..974579) Escherichia coli ED1a 7142706 YP_002396970.1 CDS insM NC_011745.1 974615 974917 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS600 complement(974615..974917) Escherichia coli ED1a 7141057 YP_002396971.1 CDS ycaQ NC_011745.1 974933 975157 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 974933..975157 Escherichia coli ED1a 7141164 YP_002396972.1 CDS ycaR NC_011745.1 975209 975391 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 975209..975391 Escherichia coli ED1a 7142707 YP_002396973.1 CDS kdsB NC_011745.1 975388 976134 D CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 975388..976134 Escherichia coli ED1a 7142708 YP_002396974.1 CDS ycbJ NC_011745.1 976288 977181 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 976288..977181 Escherichia coli ED1a 7142499 YP_002396975.1 CDS ycbC NC_011745.1 977158 977937 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(977158..977937) Escherichia coli ED1a 7142712 YP_002396976.1 CDS smtA NC_011745.1 978073 978858 D involved in cellular zinc and cadmium homeostasis by binding excess metal ions to its cysteine sulfurs and histidine nitrogens; expression of smtA in cyanobacteria is repressed by SmtB at low concentrations of zinc; NO elicits release of Zn ions from SmtA; putative metallothionein SmtA 978073..978858 Escherichia coli ED1a 7142710 YP_002396977.1 CDS mukF NC_011745.1 978855 980177 D acts with MukB and MukE to condense the chromosome and allow for segregation during cell division; condesin subunit F 978855..980177 Escherichia coli ED1a 7143813 YP_002396978.1 CDS mukE NC_011745.1 980185 980862 D acts with MukB and MukF to condense the chromosome and allow for segregation during cell division; condesin subunit E 980185..980862 Escherichia coli ED1a 7139044 YP_002396979.1 CDS mukB NC_011745.1 980862 985322 D SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects; cell division protein MukB 980862..985322 Escherichia coli ED1a 7139043 YP_002396980.1 CDS ycbB NC_011745.1 985583 987430 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 985583..987430 Escherichia coli ED1a 7139042 YP_002396981.1 CDS ycbK NC_011745.1 987611 988159 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 987611..988159 Escherichia coli ED1a 7142709 YP_002396982.1 CDS ycbL NC_011745.1 988186 988833 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14529289; Product type pe : putative enzyme; putative metal-binding hydrolase 988186..988833 Escherichia coli ED1a 7142713 YP_002396983.1 CDS aspC NC_011745.1 988883 990073 R catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase complement(988883..990073) Escherichia coli ED1a 7142714 YP_002396984.1 CDS ompF NC_011745.1 990258 991346 R outer membrane porin F; 1a; Ia; b; outer membrane protein F complement(990258..991346) Escherichia coli ED1a 7142650 YP_002396985.1 CDS asnC NC_011745.1 991949 993349 R catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase complement(991949..993349) Escherichia coli ED1a 7139969 YP_002396986.1 CDS pncB NC_011745.1 993518 994720 R catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase complement(993518..994720) Escherichia coli ED1a 7142648 YP_002396987.1 CDS pepN NC_011745.1 994986 997598 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21101837, 86164315, 87163509, 2436977, 3018440; Product type e : enzyme; aminopeptidase N 994986..997598 Escherichia coli ED1a 7139076 YP_002396988.1 CDS ssuB NC_011745.1 997641 998408 R part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic substrate-binding subunit, SsuB the ATP-binding subunit and SsuC the permease; aliphatic sulfonates transport ATP-binding subunit complement(997641..998408) Escherichia coli ED1a 7144062 YP_002396989.1 CDS ssuC NC_011745.1 998405 999196 R part of the ABC type transport system for alkanesulfonate SsuABC; SsuB the ATP-binding subunit and SsuC the permease; alkanesulfonate transporter permease subunit complement(998405..999196) Escherichia coli ED1a 7143857 YP_002396990.1 CDS ssuD NC_011745.1 999208 1000353 R catalyzes the release of sulfite from alkanesulfonates; alkanesulfonate monooxygenase complement(999208..1000353) Escherichia coli ED1a 7143858 YP_002396991.1 CDS ssuA NC_011745.1 1000350 1001309 R part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic subunit SsuB the ATP-binding subunit and SsuC the permease; alkanesulfonate transporter substrate-binding subunit complement(1000350..1001309) Escherichia coli ED1a 7143859 YP_002396992.1 CDS ssuE NC_011745.1 1001302 1001877 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20245523, 99410391, 99436146, 8774726; Product type e : enzyme; NAD(P)H-dependent FMN reductase complement(1001302..1001877) Escherichia coli ED1a 7143856 YP_002396993.1 CDS pyrD NC_011745.1 1002114 1003124 D catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 1002114..1003124 Escherichia coli ED1a 7143860 YP_002396994.1 CDS ycbW NC_011745.1 1003298 1003840 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1003298..1003840 Escherichia coli ED1a 7141233 YP_002396995.1 CDS ycbX NC_011745.1 1003837 1004946 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1327782; Product type pe : putative enzyme; putative 2Fe-2S cluster-containing protein complement(1003837..1004946) Escherichia coli ED1a 7142715 YP_002396996.1 CDS rlmL NC_011745.1 1005044 1007152 D catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA; 23S rRNA m(2)G2445 methyltransferase 1005044..1007152 Escherichia coli ED1a 7142716 YP_002396997.1 CDS uup NC_011745.1 1007164 1009071 D Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth; ABC transporter ATPase 1007164..1009071 Escherichia coli ED1a 7142717 YP_002396998.1 CDS pqiA NC_011745.1 1009201 1010454 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95270582; Product type cp : cell process; paraquat-inducible membrane protein A 1009201..1010454 Escherichia coli ED1a 7139149 YP_002396999.1 CDS pqiB NC_011745.1 1010459 1012099 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95270582; Product type cp : cell process; paraquat-inducible protein B 1010459..1012099 Escherichia coli ED1a 7139111 YP_002397000.1 CDS ymbA NC_011745.1 1012111 1012659 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1012111..1012659 Escherichia coli ED1a 7139112 YP_002397001.1 CDS rmf NC_011745.1 1012915 1013082 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1101029, 90207255, 2832401, 8440252; Product type f : factor; ribosome modulation factor 1012915..1013082 Escherichia coli ED1a 7140972 YP_002397002.1 CDS fabA NC_011745.1 1013152 1013670 R catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP; 3-hydroxydecanoyl-(acyl carrier protein) dehydratase complement(1013152..1013670) Escherichia coli ED1a 7141428 YP_002397003.1 CDS ycbZ NC_011745.1 1013739 1015499 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ATP-dependent protease complement(1013739..1015499) Escherichia coli ED1a 7139837 YP_002397004.1 CDS ycbG NC_011745.1 1015685 1016137 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1015685..1016137 Escherichia coli ED1a 7142718 YP_002397005.1 CDS ompA NC_011745.1 1016215 1017255 R OmpA is believed to be a porin, involved in diffusion of nonspecific small solutes across the outer membrane. It is the most abundant integral protein of the outer membrane of E. coli, and it is known to play a role as a phage receptor, a mediator of F-factor dependent conjugation, and in maintaining the structural shape of the outer membrane; 3a; II*; G; d; outer membrane protein A complement(1016215..1017255) Escherichia coli ED1a 7142711 YP_002397006.1 CDS sulA NC_011745.1 1017611 1018120 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10368140, 91072263, 93163041, 98348458, 3297925, 6253901, 6306396; Product type cp : cell process; SOS cell division inhibitor complement(1017611..1018120) Escherichia coli ED1a 7142461 YP_002397007.1 CDS yccR NC_011745.1 1018339 1018968 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1018339..1018968 Escherichia coli ED1a 7141499 YP_002397008.1 CDS yccS NC_011745.1 1018931 1021084 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1018931..1021084) Escherichia coli ED1a 7142723 YP_002397009.1 CDS yccF NC_011745.1 1021103 1021549 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1021103..1021549) Escherichia coli ED1a 7142724 YP_002397010.1 CDS helD NC_011745.1 1021672 1023726 D catalyzes the ATP-dependent unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand; DNA helicase IV 1021672..1023726 Escherichia coli ED1a 7142720 YP_002397011.1 CDS mgsA NC_011745.1 1023758 1024216 R catalyzes the formation of methylglyoxal from glycerone phosphate; methylglyoxal synthase complement(1023758..1024216) Escherichia coli ED1a 7139864 YP_002397012.1 CDS yccT NC_011745.1 1024312 1024974 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1024312..1024974) Escherichia coli ED1a 7142267 YP_002397013.1 CDS yccU NC_011745.1 1025147 1025560 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative CoA-binding protein 1025147..1025560 Escherichia coli ED1a 7142725 YP_002397014.1 CDS yccV NC_011745.1 1025605 1025922 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12700277, 15569148; Product type f : factor; heat shock protein HspQ complement(1025605..1025922) Escherichia coli ED1a 7142726 YP_002397015.1 CDS yccW NC_011745.1 1025980 1027083 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative AdoMet-dependent methyltransferase complement(1025980..1027083) Escherichia coli ED1a 7142727 YP_002397016.1 CDS yccX NC_011745.1 1027052 1027543 D catalyzes the hydrolysis of acylphosphate; acylphosphatase 1027052..1027543 Escherichia coli ED1a 7142728 YP_002397017.1 CDS tusE NC_011745.1 1027540 1027869 R transfers sulfur from TusBCD complex to MnmA; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein TusE complement(1027540..1027869) Escherichia coli ED1a 7142729 YP_002397018.1 CDS yccA NC_011745.1 1027961 1028620 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6376117; Product type m : membrane component; hypothetical protein complement(1027961..1028620) Escherichia coli ED1a 7140849 YP_002397019.1 CDS ECED1_0994 NC_011745.1 1029028 1030047 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative integrase from prophage complement(1029028..1030047) Escherichia coli ED1a 7142719 YP_002397020.1 CDS ECED1_0995 NC_011745.1 1030025 1030267 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(1030025..1030267) Escherichia coli ED1a 7141058 YP_002397021.1 CDS ECED1_0996 NC_011745.1 1030335 1032806 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative exonuclease from phage origin complement(1030335..1032806) Escherichia coli ED1a 7141059 YP_002397022.1 CDS ECED1_0997 NC_011745.1 1032901 1033089 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1032901..1033089) Escherichia coli ED1a 7141060 YP_002397023.1 CDS dicB NC_011745.1 1033086 1033274 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 3041373; Product type h : extrachromosomal origin; Cell division inhibition protein dicB from bacteriophage origin complement(1033086..1033274) Escherichia coli ED1a 7141061 YP_002397024.1 CDS ECED1_0999 NC_011745.1 1033588 1033848 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1033588..1033848 Escherichia coli ED1a 7143116 YP_002397025.1 CDS ECED1_1000 NC_011745.1 1033778 1034044 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1033778..1034044 Escherichia coli ED1a 7141062 YP_002397026.1 CDS ECED1_1001 NC_011745.1 1034033 1034383 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1034033..1034383) Escherichia coli ED1a 7141063 YP_002397027.1 CDS ydfA NC_011745.1 1034383 1034616 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(1034383..1034616) Escherichia coli ED1a 7141064 YP_002397028.1 CDS ECED1_1003 NC_011745.1 1034810 1035100 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative plasmid stabilization-like protein from prophage complement(1034810..1035100) Escherichia coli ED1a 7139257 YP_002397029.1 CDS ECED1_1004 NC_011745.1 1035100 1035291 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1035100..1035291) Escherichia coli ED1a 7141065 YP_002397030.1 CDS ECED1_1005 NC_011745.1 1035309 1035809 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative regulator of the C1 family from prophage complement(1035309..1035809) Escherichia coli ED1a 7141066 YP_002397031.1 CDS ECED1_1006 NC_011745.1 1035917 1036180 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative regulator of the C1 family (possibly fragment) 1035917..1036180 Escherichia coli ED1a 7141067 YP_002397032.1 CDS ECED1_1007 NC_011745.1 1036177 1036602 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1036177..1036602 Escherichia coli ED1a 7141068 YP_002397033.1 CDS ECED1_1008 NC_011745.1 1036610 1037587 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage replication protein O (weak confidence) 1036610..1037587 Escherichia coli ED1a 7141069 YP_002397034.1 CDS ydaV NC_011745.1 1037594 1038340 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative replication protein 1037594..1038340 Escherichia coli ED1a 7141070 YP_002397035.1 CDS ECED1_1010 NC_011745.1 1038362 1039132 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1038362..1039132 Escherichia coli ED1a 7142015 YP_002397036.1 CDS ECED1_1011 NC_011745.1 1039133 1039570 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1039133..1039570 Escherichia coli ED1a 7141071 YP_002397037.1 CDS ECED1_1012 NC_011745.1 1039738 1040376 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative NUDIX hydrolase 1039738..1040376 Escherichia coli ED1a 7141072 YP_002397038.1 CDS ECED1_1013 NC_011745.1 1040400 1041044 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative 2-deoxyglucose-6-phosphatase 1040400..1041044 Escherichia coli ED1a 7141073 YP_002397039.1 CDS ECED1_1014 NC_011745.1 1041045 1041233 R Evidence 6 : Doubtful CDS; hypothetical protein complement(1041045..1041233) Escherichia coli ED1a 7141074 YP_002397040.1 CDS ydfU NC_011745.1 1042212 1043261 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1042212..1043261 Escherichia coli ED1a 7141076 YP_002397041.1 CDS ECED1_1017 NC_011745.1 1043267 1043467 D Evidence 6 : Doubtful CDS; hypothetical protein 1043267..1043467 Escherichia coli ED1a 7139269 YP_002397042.1 CDS ECED1_1018 NC_011745.1 1043274 1043633 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative crossover junction endodeoxyribonuclease RusA 1043274..1043633 Escherichia coli ED1a 7141077 YP_002397043.1 CDS ECED1_1019 NC_011745.1 1043630 1044202 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1043630..1044202 Escherichia coli ED1a 7141078 YP_002397044.1 CDS ECED1_1020 NC_011745.1 1044297 1044617 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1044297..1044617 Escherichia coli ED1a 7141079 YP_002397045.1 CDS ECED1_1021 NC_011745.1 1044768 1045826 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative DNA adenine methyltransferase ( DNA methylase) from phage origin 1044768..1045826 Escherichia coli ED1a 7141080 YP_002397046.1 CDS ECED1_1022 NC_011745.1 1046684 1048666 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1046684..1048666 Escherichia coli ED1a 7140781 YP_002397047.1 CDS ECED1_1023 NC_011745.1 1048620 1048793 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1048620..1048793 Escherichia coli ED1a 7141082 YP_002397048.1 CDS ECED1_1024 NC_011745.1 1048852 1049316 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1048852..1049316 Escherichia coli ED1a 7141083 YP_002397049.1 CDS essD NC_011745.1 1049392 1049607 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage lysis protein S 1049392..1049607 Escherichia coli ED1a 7141084 YP_002397050.1 CDS ECED1_1026 NC_011745.1 1049612 1050247 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1049612..1050247 Escherichia coli ED1a 7139811 YP_002397051.1 CDS ECED1_1027 NC_011745.1 1050195 1050680 R Evidence 6 : Doubtful CDS; hypothetical protein complement(1050195..1050680) Escherichia coli ED1a 7141085 YP_002397052.1 CDS ydfQ NC_011745.1 1050567 1051100 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-associated lysozyme; Qin prophage 1050567..1051100 Escherichia coli ED1a 7141086 YP_002397053.1 CDS ECED1_1029 NC_011745.1 1051224 1051439 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1051224..1051439 Escherichia coli ED1a 7139263 YP_002397054.1 CDS ECED1_1030 NC_011745.1 1051364 1051585 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1051364..1051585 Escherichia coli ED1a 7141087 YP_002397055.1 CDS rz NC_011745.1 1051582 1052055 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Endopeptidase (Lysis protein) from bacteriophage origin 1051582..1052055 Escherichia coli ED1a 7141088 YP_002397056.1 CDS ECED1_1032 NC_011745.1 1052079 1052303 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1052079..1052303 Escherichia coli ED1a 7141356 YP_002397057.1 CDS ECED1_1033 NC_011745.1 1052758 1053267 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative terminase small subunit (DNA packaging protein Nu1) from bacteriophage origin 1052758..1053267 Escherichia coli ED1a 7141089 YP_002397058.1 CDS ECED1_1034 NC_011745.1 1053182 1055167 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; terminase large subunit (Gp2) 1053182..1055167 Escherichia coli ED1a 7141090 YP_002397059.1 CDS ECED1_1035 NC_011745.1 1055151 1055357 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; head stabilization protein 1055151..1055357 Escherichia coli ED1a 7141091 YP_002397060.1 CDS ECED1_1036 NC_011745.1 1055354 1056946 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; head protein Gp4 1055354..1056946 Escherichia coli ED1a 7141092 YP_002397061.1 CDS ECED1_1037 NC_011745.1 1056936 1058441 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; head-tail preconnector protein GP5 1056936..1058441 Escherichia coli ED1a 7141093 YP_002397062.1 CDS ECED1_1038 NC_011745.1 1058478 1058825 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; major capsid protein D 1058478..1058825 Escherichia coli ED1a 7141094 YP_002397063.1 CDS ECED1_1039 NC_011745.1 1058883 1059911 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; major head protein 1058883..1059911 Escherichia coli ED1a 7141095 YP_002397064.1 CDS ECED1_1040 NC_011745.1 1059964 1060332 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative DNA packaging protein from phage origin 1059964..1060332 Escherichia coli ED1a 7141096 YP_002397065.1 CDS ECED1_1041 NC_011745.1 1060310 1060678 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail attachment protein 1060310..1060678 Escherichia coli ED1a 7141097 YP_002397066.1 CDS ECED1_1042 NC_011745.1 1060694 1061227 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein Z (GpZ) 1060694..1061227 Escherichia coli ED1a 7141098 YP_002397067.1 CDS ECED1_1043 NC_011745.1 1061224 1061619 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein U 1061224..1061619 Escherichia coli ED1a 7141099 YP_002397068.1 CDS V NC_011745.1 1061627 1062373 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; major tail protein V 1061627..1062373 Escherichia coli ED1a 7142827 YP_002397069.1 CDS ECED1_1045 NC_011745.1 1062377 1062826 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein G 1062377..1062826 Escherichia coli ED1a 7139162 YP_002397070.1 CDS ECED1_1046 NC_011745.1 1062853 1063266 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein T 1062853..1063266 Escherichia coli ED1a 7143481 YP_002397071.1 CDS ECED1_1047 NC_011745.1 1063247 1065808 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein H 1063247..1065808 Escherichia coli ED1a 7143482 YP_002397072.1 CDS ECED1_1048 NC_011745.1 1065805 1066134 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein M 1065805..1066134 Escherichia coli ED1a 7143483 YP_002397073.1 CDS ECED1_1049 NC_011745.1 1066032 1066148 R Evidence 6 : Doubtful CDS; hypothetical protein complement(1066032..1066148) Escherichia coli ED1a 7143484 YP_002397074.1 CDS ECED1_1050 NC_011745.1 1066134 1066832 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein L 1066134..1066832 Escherichia coli ED1a 7143485 YP_002397075.1 CDS ECED1_1051 NC_011745.1 1066582 1067586 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail fiber component K 1066582..1067586 Escherichia coli ED1a 7143486 YP_002397076.1 CDS ECED1_1052 NC_011745.1 1067484 1068164 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail assembly protein I 1067484..1068164 Escherichia coli ED1a 7143487 YP_002397077.1 CDS J NC_011745.1 1068370 1071945 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Host specificity protein J from prophage 1068370..1071945 Escherichia coli ED1a 7143488 YP_002397078.1 CDS ECED1_1054 NC_011745.1 1072130 1073683 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative tail fiber protein from prophage 1072130..1073683 Escherichia coli ED1a 7142479 YP_002397079.1 CDS ECED1_1055 NC_011745.1 1073703 1074281 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1073703..1074281 Escherichia coli ED1a 7143489 YP_002397080.1 CDS hyaA NC_011745.1 1075360 1076478 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86192450, 90202716, 92215587; Product type e : enzyme; hydrogenase 1, small subunit 1075360..1076478 Escherichia coli ED1a 7140631 YP_002397081.1 CDS hyaB NC_011745.1 1076475 1078268 D involved in hydrogen cycling during fermentative growth; hydrogenase 1 large subunit 1076475..1078268 Escherichia coli ED1a 7140180 YP_002397082.1 CDS hyaC NC_011745.1 1078287 1078994 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90202716, 91310595, 92215587; Product type c : carrier; hydrogenase 1 b-type cytochrome subunit 1078287..1078994 Escherichia coli ED1a 7140181 YP_002397083.1 CDS hyaD NC_011745.1 1078991 1079578 D HyaD; endopeptidase involved in the cleavage of the C-terminus end of HyaB (the large subunit of hydrogenase 1); hydrogenase 1 maturation protease 1078991..1079578 Escherichia coli ED1a 7140182 YP_002397084.1 CDS hyaE NC_011745.1 1079575 1079973 D involved in processing hydrogenase proteins HyaA and HyaB; hydrogenase-1 operon protein HyaE 1079575..1079973 Escherichia coli ED1a 7140183 YP_002397085.1 CDS hyaF NC_011745.1 1079970 1080827 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90202716, 91310595, 92215587; Product type f : factor; protein involved in nickel incorporation into hydrogenase-1 proteins 1079970..1080827 Escherichia coli ED1a 7140184 YP_002397086.1 CDS appC NC_011745.1 1080961 1082505 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92049231, 96198179; Product type c : carrier; cytochrome bd-II oxidase subunit I 1080961..1082505 Escherichia coli ED1a 7140185 YP_002397087.1 CDS appB NC_011745.1 1082517 1083653 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92049231, 96198179; Product type c : carrier; cytochrome bd-II oxidase subunit II 1082517..1083653 Escherichia coli ED1a 7142593 YP_002397088.1 CDS appA NC_011745.1 1083850 1085148 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20122624, 92049231, 93054596, 10696472, 2168385, 3038201, 8387749; Product type e : enzyme; phosphoanhydride phosphorylase 1083850..1085148 Escherichia coli ED1a 7142592 YP_002397089.1 CDS cspH NC_011745.1 1085136 1085348 R Evidence 2b : Function of strongly homologous gene; PubMedId : 9484881, 9439003; Product type f : factor; stress protein, member of the CspA-family complement(1085136..1085348) Escherichia coli ED1a 7142591 YP_002397090.1 CDS cspG NC_011745.1 1085632 1085844 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9484881, 15466053, 8631696, 9439003; Product type r : regulator; cold shock protein CspG 1085632..1085844 Escherichia coli ED1a 7142074 YP_002397091.1 CDS gnsA NC_011745.1 1086238 1086411 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15317805, 11544213; Product type pr : putative regulator; putative regulator of phosphatidylethanolamine synthesis 1086238..1086411 Escherichia coli ED1a 7142073 YP_002397092.1 CDS yccM NC_011745.1 1086460 1087533 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative 4Fe-4S membrane protein complement(1086460..1087533) Escherichia coli ED1a 7142999 YP_002397093.1 CDS torS NC_011745.1 1087616 1090348 R Member of the two-component regulatory system torS/torR involved in the anaerobic utilization of trimethylamine-N-oxide; hybrid sensory histidine kinase TorS complement(1087616..1090348) Escherichia coli ED1a 7142722 YP_002397094.1 CDS torT NC_011745.1 1090431 1091459 D periplasmic sensory protein associated with the TorRS two-component regulatory system; TMAO reductase system periplasmic protein TorT 1090431..1091459 Escherichia coli ED1a 7140796 YP_002397095.1 CDS torR NC_011745.1 1091432 1092124 R response regulator in two-component regulatory system with TorS; involved in regulation of trimethylamine N-oxide reductase genes; DNA-binding transcriptional regulator TorR complement(1091432..1092124) Escherichia coli ED1a 7140797 YP_002397096.1 CDS torC NC_011745.1 1092254 1093426 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94293785, 94314186, 99340208, 11056172, 11562502; Product type c : carrier; trimethylamine N-oxide (TMAO) reductase I, cytochrome c-type subunit 1092254..1093426 Escherichia coli ED1a 7140795 YP_002397097.1 CDS torA NC_011745.1 1093426 1095972 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88193091, 90089471, 94293785, 8302830, 8022286; Product type e : enzyme; trimethylamine N-oxide (TMAO) reductase I, catalytic subunit 1093426..1095972 Escherichia coli ED1a 7140793 YP_002397098.1 CDS torD NC_011745.1 1095969 1096568 D TorD; involved in the biogenesis of torA; acts on torA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor; chaperone protein TorD 1095969..1096568 Escherichia coli ED1a 7140792 YP_002397099.1 CDS cbpM NC_011745.1 1096925 1097230 R with CpbA modulates the activity of the dnaK chaperone system; interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA; chaperone-modulator protein CbpM complement(1096925..1097230) Escherichia coli ED1a 7140794 YP_002397100.1 CDS cbpA NC_011745.1 1097230 1098150 R functional analog of DnaJ; co-chaperone with DnaK, molecular chaperone in an adaptive response to environmental stresses other than heat shock; curved DNA-binding protein CbpA complement(1097230..1098150) Escherichia coli ED1a 7139310 YP_002397101.1 CDS insA NC_011745.1 1099143 1099418 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 1099143..1099418 Escherichia coli ED1a 7143679 YP_002397102.1 CDS insB NC_011745.1 1099337 1099840 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 1099337..1099840 Escherichia coli ED1a 7141116 YP_002397103.1 CDS yccJ NC_011745.1 1100740 1100967 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1100740..1100967) Escherichia coli ED1a 7143680 YP_002397104.1 CDS wrbA NC_011745.1 1100988 1101566 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16322580, 93296226, 9694845; Product type pr : putative regulator; putative flavoprotein complement(1100988..1101566) Escherichia coli ED1a 7142721 YP_002397105.1 CDS int NC_011745.1 1101563 1102897 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; phage integrase complement(1101563..1102897) Escherichia coli ED1a 7139189 YP_002397106.1 CDS ECED1_1085 NC_011745.1 1102926 1103210 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative excisionase complement(1102926..1103210) Escherichia coli ED1a 7141173 YP_002397107.1 CDS ECED1_1086 NC_011745.1 1103256 1103516 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(1103256..1103516) Escherichia coli ED1a 7143491 YP_002397108.1 CDS ECED1_1087 NC_011745.1 1103555 1104235 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; exonuclease from phage origin complement(1103555..1104235) Escherichia coli ED1a 7143492 YP_002397109.1 CDS ECED1_1088 NC_011745.1 1104232 1105017 R Evidence 2b : Function of strongly homologous gene; PubMedId : 6458018, 6221115; Product type h : extrachromosomal origin; Recombination protein bet from phage origin complement(1104232..1105017) Escherichia coli ED1a 7143493 YP_002397110.1 CDS ECED1_1089 NC_011745.1 1105023 1105319 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative host-nuclease inhibitor protein Gam of bacteriophage complement(1105023..1105319) Escherichia coli ED1a 7143494 YP_002397111.1 CDS ECED1_1090 NC_011745.1 1105316 1107388 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2199308; Product type h : extrachromosomal origin; Exodeoxyribonuclease VIII (putative partial) from phage origin complement(1105316..1107388) Escherichia coli ED1a 7143495 YP_002397112.1 CDS ECED1_1091 NC_011745.1 1107496 1107882 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(1107496..1107882) Escherichia coli ED1a 7143496 YP_002397113.1 CDS kil NC_011745.1 1107966 1108187 R Rac prophage Kil protein; Kil overexpression leads to morphological defects and inhibits cell division; FtsZ inhibitor protein complement(1107966..1108187) Escherichia coli ED1a 7143497 YP_002397114.1 CDS ECED1_1093 NC_011745.1 1108644 1108853 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1108644..1108853 Escherichia coli ED1a 7142512 YP_002397115.1 CDS ECED1_1094 NC_011745.1 1108822 1109202 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(1108822..1109202) Escherichia coli ED1a 7143498 YP_002397116.1 CDS ECED1_1095 NC_011745.1 1109213 1109929 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(1109213..1109929) Escherichia coli ED1a 7143499 YP_002397117.1 CDS N NC_011745.1 1109930 1110313 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Antitermination protein N complement(1109930..1110313) Escherichia coli ED1a 7143500 YP_002397118.1 CDS ECED1_1097 NC_011745.1 1110811 1111587 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(1110811..1111587) Escherichia coli ED1a 7140327 YP_002397119.1 CDS ECED1_1098 NC_011745.1 1111575 1112117 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(1111575..1112117) Escherichia coli ED1a 7143501 YP_002397120.1 CDS CI NC_011745.1 1112164 1112877 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Repressor protein CI from prophage complement(1112164..1112877) Escherichia coli ED1a 7143502 YP_002397121.1 CDS cro NC_011745.1 1112978 1113178 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; regulatory protein cro 1112978..1113178 Escherichia coli ED1a 7139353 YP_002397122.1 CDS cII NC_011745.1 1113317 1113613 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; regulatory protein CII from prophage 1113317..1113613 Escherichia coli ED1a 7142055 YP_002397123.1 CDS ECED1_1102 NC_011745.1 1113628 1113846 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1113628..1113846 Escherichia coli ED1a 7139356 YP_002397124.1 CDS ECED1_1103 NC_011745.1 1113867 1114955 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1113867..1114955 Escherichia coli ED1a 7143503 YP_002397125.1 CDS ydaV NC_011745.1 1114962 1115702 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative replication protein 1114962..1115702 Escherichia coli ED1a 7143504 YP_002397126.1 CDS ECED1_1105 NC_011745.1 1115728 1116498 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1115728..1116498 Escherichia coli ED1a 7142016 YP_002397127.1 CDS ECED1_1106 NC_011745.1 1116508 1116945 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1116508..1116945 Escherichia coli ED1a 7143505 YP_002397128.1 CDS ECED1_1107 NC_011745.1 1116978 1117652 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(1116978..1117652) Escherichia coli ED1a 7143506 YP_002397129.1 CDS ECED1_1108 NC_011745.1 1117546 1117896 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1117546..1117896 Escherichia coli ED1a 7143507 YP_002397130.1 CDS ECED1_1109 NC_011745.1 1117951 1118259 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative transcriptional regulator from the CI family complement(1117951..1118259) Escherichia coli ED1a 7143508 YP_002397131.1 CDS ECED1_1110 NC_011745.1 1118249 1118716 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(1118249..1118716) Escherichia coli ED1a 7143509 YP_002397132.1 CDS ECED1_1111 NC_011745.1 1118898 1119569 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative antirepressor protein Ant from prophage 1118898..1119569 Escherichia coli ED1a 7143510 YP_002397133.1 CDS ECED1_1112 NC_011745.1 1119624 1120034 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative ninB protein 1119624..1120034 Escherichia coli ED1a 7143511 YP_002397134.1 CDS ECED1_1113 NC_011745.1 1120298 1120489 D Evidence 6 : Doubtful CDS; hypothetical protein 1120298..1120489 Escherichia coli ED1a 7143512 YP_002397135.1 CDS rusA NC_011745.1 1120533 1120895 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; crossover junction endodeoxyribonuclease 1120533..1120895 Escherichia coli ED1a 7143513 YP_002397136.1 CDS ninH NC_011745.1 1120892 1121092 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Protein ninH from prophage 1120892..1121092 Escherichia coli ED1a 7140137 YP_002397137.1 CDS ECED1_1116 NC_011745.1 1120980 1121327 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1120980..1121327 Escherichia coli ED1a 7140393 YP_002397138.1 CDS ECED1_1117 NC_011745.1 1121315 1121941 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1121315..1121941 Escherichia coli ED1a 7143514 YP_002397139.1 CDS ECED1_1118 NC_011745.1 1122217 1122456 R Evidence 6 : Doubtful CDS; hypothetical protein complement(1122217..1122456) Escherichia coli ED1a 7143515 YP_002397140.1 CDS ECED1_1119 NC_011745.1 1122679 1122846 D Evidence 6 : Doubtful CDS; hypothetical protein 1122679..1122846 Escherichia coli ED1a 7143516 YP_002397141.1 CDS ECED1_1120 NC_011745.1 1122910 1123068 D Evidence 6 : Doubtful CDS; hypothetical protein 1122910..1123068 Escherichia coli ED1a 7143517 YP_002397142.1 CDS ECED1_1121 NC_011745.1 1123361 1125364 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; hypothetical protein 1123361..1125364 Escherichia coli ED1a 7143518 YP_002397143.1 CDS ECED1_1122 NC_011745.1 1125552 1126016 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1125552..1126016 Escherichia coli ED1a 7143519 YP_002397144.1 CDS S NC_011745.1 1126093 1126308 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2019562; Product type h : extrachromosomal origin; Lysis protein S from bacteriophage origin 1126093..1126308 Escherichia coli ED1a 7143520 YP_002397145.1 CDS ydfQ NC_011745.1 1126313 1126846 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-associated lysozyme; Qin prophage 1126313..1126846 Escherichia coli ED1a 7141362 YP_002397146.1 CDS ECED1_1125 NC_011745.1 1126970 1127185 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1126970..1127185 Escherichia coli ED1a 7139264 YP_002397147.1 CDS ECED1_1126 NC_011745.1 1127110 1127331 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1127110..1127331 Escherichia coli ED1a 7143521 YP_002397148.1 CDS rz NC_011745.1 1127339 1127806 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Endopeptidase (Lysis protein) from bacteriophage origin 1127339..1127806 Escherichia coli ED1a 7143522 YP_002397149.1 CDS ECED1_1128 NC_011745.1 1127983 1128534 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage protein Rha 1127983..1128534 Escherichia coli ED1a 7141357 YP_002397150.1 CDS ECED1_1129 NC_011745.1 1128834 1129616 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative small subunit terminase from prophage 1128834..1129616 Escherichia coli ED1a 7143523 YP_002397151.1 CDS ECED1_1130 NC_011745.1 1129597 1131303 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative large subunit terminase 1129597..1131303 Escherichia coli ED1a 7143524 YP_002397152.1 CDS ECED1_1131 NC_011745.1 1131303 1133447 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative portal protein 1131303..1133447 Escherichia coli ED1a 7143525 YP_002397153.1 CDS ECED1_1132 NC_011745.1 1133605 1134612 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1133605..1134612 Escherichia coli ED1a 7143526 YP_002397154.1 CDS ECED1_1133 NC_011745.1 1134635 1135849 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1134635..1135849 Escherichia coli ED1a 7143527 YP_002397155.1 CDS ECED1_1134 NC_011745.1 1135904 1136296 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1135904..1136296 Escherichia coli ED1a 7143528 YP_002397156.1 CDS ECED1_1135 NC_011745.1 1136347 1136808 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1136347..1136808 Escherichia coli ED1a 7143529 YP_002397157.1 CDS ECED1_1136 NC_011745.1 1136732 1137355 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1136732..1137355 Escherichia coli ED1a 7143530 YP_002397158.1 CDS ECED1_1137 NC_011745.1 1137355 1138005 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1137355..1138005 Escherichia coli ED1a 7143531 YP_002397159.1 CDS ECED1_1138 NC_011745.1 1138002 1139702 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1138002..1139702 Escherichia coli ED1a 7143532 YP_002397160.1 CDS ECED1_1139 NC_011745.1 1139722 1140300 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1139722..1140300 Escherichia coli ED1a 7143533 YP_002397161.1 CDS ECED1_1140 NC_011745.1 1140488 1140637 R Evidence 6 : Doubtful CDS; hypothetical protein complement(1140488..1140637) Escherichia coli ED1a 7143534 YP_002397162.1 CDS ECED1_1141 NC_011745.1 1141109 1142188 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative immunoglobulin-binding protein from phage origin 1141109..1142188 Escherichia coli ED1a 7143535 YP_002397163.1 CDS ECED1_1142 NC_011745.1 1142247 1142747 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1142247..1142747 Escherichia coli ED1a 7143536 YP_002397164.1 CDS ECED1_1143 NC_011745.1 1142747 1142929 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1142747..1142929 Escherichia coli ED1a 7143537 YP_002397165.1 CDS ECED1_1144 NC_011745.1 1143032 1144735 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1143032..1144735 Escherichia coli ED1a 7143538 YP_002397166.1 CDS ECED1_1145 NC_011745.1 1144732 1146000 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1144732..1146000 Escherichia coli ED1a 7143539 YP_002397167.1 CDS ECED1_1146 NC_011745.1 1146015 1146296 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1146015..1146296 Escherichia coli ED1a 7143540 YP_002397168.1 CDS ECED1_1147 NC_011745.1 1146293 1146919 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1146293..1146919 Escherichia coli ED1a 7143541 YP_002397169.1 CDS lom NC_011745.1 1147006 1147737 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; outer membrane protein Lom 1147006..1147737 Escherichia coli ED1a 7143542 YP_002397170.1 CDS ECED1_1149 NC_011745.1 1148165 1148566 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1148165..1148566 Escherichia coli ED1a 7141905 YP_002397171.1 CDS ECED1_1150 NC_011745.1 1148660 1149316 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1148660..1149316 Escherichia coli ED1a 7143543 YP_002397172.1 CDS ECED1_1151 NC_011745.1 1149319 1149765 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1149319..1149765 Escherichia coli ED1a 7143544 YP_002397173.1 CDS ECED1_1152 NC_011745.1 1149775 1150026 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1149775..1150026 Escherichia coli ED1a 7143545 YP_002397174.1 CDS ECED1_1153 NC_011745.1 1150037 1151302 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1150037..1151302 Escherichia coli ED1a 7143546 YP_002397175.1 CDS ECED1_1154 NC_011745.1 1151371 1159734 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1151371..1159734 Escherichia coli ED1a 7143547 YP_002397176.1 CDS ECED1_1155 NC_011745.1 1159885 1160409 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1159885..1160409 Escherichia coli ED1a 7143548 YP_002397177.1 CDS ibrB NC_011745.1 1160498 1161142 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; transcriptional regulator IbrB complement(1160498..1161142) Escherichia coli ED1a 7142526 YP_002397178.1 CDS ibrA NC_011745.1 1161127 1162353 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12057959; Product type r : regulator; immunoglobulin-binding regulator complement(1161127..1162353) Escherichia coli ED1a 7140220 YP_002397179.1 CDS antB NC_011745.1 1162550 1163341 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; phage anti-repressor protein complement(1162550..1163341) Escherichia coli ED1a 7140218 YP_002397180.1 CDS ECED1_1159 NC_011745.1 1163460 1163897 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(1163460..1163897) Escherichia coli ED1a 7142587 YP_002397181.1 CDS ECED1_1160 NC_011745.1 1164544 1164780 D Evidence 6 : Doubtful CDS; hypothetical protein 1164544..1164780 Escherichia coli ED1a 7142527 YP_002397182.1 CDS ymdF NC_011745.1 1164713 1164886 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1164713..1164886 Escherichia coli ED1a 7142528 YP_002397183.1 CDS rutG NC_011745.1 1164969 1166297 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type t : transporter; pyrimidine transporter complement(1164969..1166297) Escherichia coli ED1a 7140976 YP_002397184.1 CDS rutF NC_011745.1 1166318 1166812 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542, 10633095; Product type e : enzyme; alternative pyrimidine degradation pathway flavin:NADH oxidoreductase subunit complement(1166318..1166812) Escherichia coli ED1a 7140144 YP_002397185.1 CDS rutE NC_011745.1 1166823 1167413 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme; hypothetical protein complement(1166823..1167413) Escherichia coli ED1a 7140143 YP_002397186.1 CDS rutD NC_011745.1 1167423 1168223 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme; enzyme of the alternative pyrimidine degradation pathway complement(1167423..1168223) Escherichia coli ED1a 7140142 YP_002397187.1 CDS rutC NC_011745.1 1168231 1168617 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme; enzyme of the alternative pyrimidine degradation pathway complement(1168231..1168617) Escherichia coli ED1a 7140141 YP_002397188.1 CDS rutB NC_011745.1 1168629 1169321 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme; enzyme of the alternative pyrimidine degradation pathway complement(1168629..1169321) Escherichia coli ED1a 7140140 YP_002397189.1 CDS rutA NC_011745.1 1169321 1170469 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme; alternative pyrimidine degradation pathway monooxygenase complement(1169321..1170469) Escherichia coli ED1a 7140139 YP_002397190.1 CDS rutR NC_011745.1 1170693 1171331 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type r : regulator; alternative pyrimidine degradation pathway DNA-binding transcriptional regulator 1170693..1171331 Escherichia coli ED1a 7140138 YP_002397191.1 CDS putA NC_011745.1 1171371 1175333 R proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichai coli this protein also self-regulates transcription via a DNA-binding domain at the N-terminus; forms dimers and is a peripherally membrane-associated protein; trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase complement(1171371..1175333) Escherichia coli ED1a 7140145 YP_002397192.1 CDS putP NC_011745.1 1175756 1177264 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12923181, 88213396, 91227628, 93132799, 98359785, 1400239, 1567896, 3053649, 3053687, 3302614, 3325781, 8119910; Product type t : transporter; proline:sodium symporter 1175756..1177264 Escherichia coli ED1a 7141227 YP_002397193.1 CDS efeU NC_011745.1 1177475 1178314 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type t : transporter; ferrous iron permease 1177475..1178314 Escherichia coli ED1a 7141228 YP_002397194.1 CDS efeO NC_011745.1 1178372 1179499 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 17627767, 10493123; Product type t : transporter; hypothetical protein 1178372..1179499 Escherichia coli ED1a 7139776 YP_002397195.1 CDS efeB NC_011745.1 1179505 1180776 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 17627767, 16551627, 15375152; Product type t : transporter; iron transport heme-binding periplasmic protein 1179505..1180776 Escherichia coli ED1a 7139775 YP_002397196.1 CDS phoH NC_011745.1 1181127 1182191 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8444794, 2160940; Product type pe : putative enzyme; hypothetical protein 1181127..1182191 Escherichia coli ED1a 7139774 YP_002397197.1 CDS ECED1_1176 NC_011745.1 1182780 1183466 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1182780..1183466 Escherichia coli ED1a 7144105 YP_002397198.1 CDS ycdW NC_011745.1 1183879 1184817 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11237876, 10493123; Product type e : enzyme; 2-ketoacid reductase 1183879..1184817 Escherichia coli ED1a 7140630 YP_002397199.1 CDS ycdX NC_011745.1 1184872 1185609 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12661000; Product type pe : putative enzyme; putative hydrolase 1184872..1185609 Escherichia coli ED1a 7142730 YP_002397200.1 CDS ycdY NC_011745.1 1185633 1186187 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1185633..1186187 Escherichia coli ED1a 7142731 YP_002397201.1 CDS ycdZ NC_011745.1 1186289 1186780 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1186289..1186780 Escherichia coli ED1a 7142732 YP_002397202.1 CDS csgG NC_011745.1 1186844 1187677 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8817489; Product type lp : lipoprotein; putative outer membrane lipoprotein involved in curli production assembly/transport complement(1186844..1187677) Escherichia coli ED1a 7142733 YP_002397203.1 CDS csgF NC_011745.1 1187704 1188120 R nucleator protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgF complement(1187704..1188120) Escherichia coli ED1a 7142066 YP_002397204.1 CDS csgE NC_011745.1 1188145 1188534 R chaperone-like protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgE complement(1188145..1188534) Escherichia coli ED1a 7142065 YP_002397205.1 CDS csgD NC_011745.1 1188539 1189189 R activates the csgBA and csgDEFG operons involved in biofilm formation; DNA-binding transcriptional regulator CsgD complement(1188539..1189189) Escherichia coli ED1a 7142064 YP_002397206.1 CDS csgB NC_011745.1 1189932 1190387 D CsgB; functions as a nucleator in the assembly of curli (coiled surface structures) on the cell surface; curlin minor subunit 1189932..1190387 Escherichia coli ED1a 7142063 YP_002397207.1 CDS csgA NC_011745.1 1190428 1190886 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89201357, 93023873, 1677357, 8459772, 8817489, 1357528; Product type s : structure; cryptic curlin major subunit 1190428..1190886 Escherichia coli ED1a 7142061 YP_002397208.1 CDS csgC NC_011745.1 1190945 1191277 D involved in autoagglutination of curliated cells; not involved in production of curli fibers; putative autoagglutination protein 1190945..1191277 Escherichia coli ED1a 7142060 YP_002397209.1 CDS ymdA NC_011745.1 1191398 1191709 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1191398..1191709 Escherichia coli ED1a 7142062 YP_002397210.1 CDS ymdB NC_011745.1 1191804 1192337 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1191804..1192337 Escherichia coli ED1a 7140973 YP_002397211.1 CDS ymdC NC_011745.1 1192339 1193760 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase 1192339..1193760 Escherichia coli ED1a 7140974 YP_002397212.1 CDS mdoC NC_011745.1 1193768 1194925 R required for the transfer of succinyl residues to the glucan backbone; glucans biosynthesis protein complement(1193768..1194925) Escherichia coli ED1a 7140975 YP_002397213.1 CDS ECED1_1192 NC_011745.1 1194970 1195113 R Evidence 6 : Doubtful CDS; hypothetical protein complement(1194970..1195113) Escherichia coli ED1a 7142223 YP_002397214.1 CDS ECED1_1193 NC_011745.1 1195117 1195275 R Evidence 6 : Doubtful CDS; hypothetical protein complement(1195117..1195275) Escherichia coli ED1a 7142530 YP_002397215.1 CDS mdoG NC_011745.1 1195319 1196854 D involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan; glucan biosynthesis protein G 1195319..1196854 Escherichia coli ED1a 7142531 YP_002397216.1 CDS mdoH NC_011745.1 1196847 1199390 D necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space; glucosyltransferase MdoH 1196847..1199390 Escherichia coli ED1a 7142225 YP_002397217.1 CDS yceK NC_011745.1 1199562 1199789 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein 1199562..1199789 Escherichia coli ED1a 7142226 YP_002397218.1 CDS msyB NC_011745.1 1199790 1200164 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 92165719; hypothetical protein complement(1199790..1200164) Escherichia coli ED1a 7143480 YP_002397219.1 CDS mdtG NC_011745.1 1200247 1201473 R Confers resistance to fosfomycin and deoxycholate; drug efflux system protein MdtG complement(1200247..1201473) Escherichia coli ED1a 7139036 YP_002397220.1 CDS lpxL NC_011745.1 1201645 1202565 R Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase complement(1201645..1202565) Escherichia coli ED1a 7142233 YP_002397221.1 CDS yceA NC_011745.1 1202790 1203842 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1840644; hypothetical protein 1202790..1203842 Escherichia coli ED1a 7141923 YP_002397222.1 CDS yceI NC_011745.1 1203884 1204459 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15741337, 11298273, 1840644, 9298646; Product type c : carrier; hypothetical protein complement(1203884..1204459) Escherichia coli ED1a 7142734 YP_002397223.1 CDS yceJ NC_011745.1 1204463 1205029 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative cytochrome b561 complement(1204463..1205029) Escherichia coli ED1a 7142740 YP_002397224.1 CDS solA NC_011745.1 1205451 1206569 R catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids; N-methyltryptophan oxidase complement(1205451..1206569) Escherichia coli ED1a 7142741 YP_002397225.1 CDS bssS NC_011745.1 1206684 1206938 R BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing; biofilm formation regulatory protein BssS complement(1206684..1206938) Escherichia coli ED1a 7143820 YP_002397226.1 CDS dinI NC_011745.1 1207228 1207473 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9606202, 11152126, 11230150, 8682790; Product type f : factor; DNA damage-inducible protein I complement(1207228..1207473) Escherichia coli ED1a 7140464 YP_002397227.1 CDS pyrC NC_011745.1 1207547 1208593 R catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase complement(1207547..1208593) Escherichia coli ED1a 7140491 YP_002397228.1 CDS yceB NC_011745.1 1208699 1209259 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein complement(1208699..1209259) Escherichia coli ED1a 7141232 YP_002397229.1 CDS grxB NC_011745.1 1209393 1210040 R cofactor involved in the reduction of disulfides; glutaredoxin 2 complement(1209393..1210040) Escherichia coli ED1a 7142735 YP_002397230.1 CDS mdtH NC_011745.1 1210104 1211312 R Confers resistance to norfloxacin and enoxacin; multidrug resistance protein MdtH complement(1210104..1211312) Escherichia coli ED1a 7143025 YP_002397231.1 CDS rimJ NC_011745.1 1211548 1212132 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88121676, 90136529, 1356970; Product type e : enzyme; ribosomal-protein-S5-alanine N-acetyltransferase 1211548..1212132 Escherichia coli ED1a 7142234 YP_002397232.1 CDS yceH NC_011745.1 1212143 1212790 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1356970, 2828880; hypothetical protein 1212143..1212790 Escherichia coli ED1a 7141417 YP_002397233.1 CDS mviM NC_011745.1 1212792 1213715 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase with NAD(P)-binding Rossmann-fold domain 1212792..1213715 Escherichia coli ED1a 7142739 YP_002397234.1 CDS mviN NC_011745.1 1213825 1215360 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1213825..1215360 Escherichia coli ED1a 7140324 YP_002397235.1 CDS flgN NC_011745.1 1215400 1215816 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10320579; Product type f : factor; export chaperone for FlgK and FlgL complement(1215400..1215816) Escherichia coli ED1a 7140325 YP_002397236.1 CDS flgM NC_011745.1 1215821 1216114 R regulates the flagellar specific sigma28 transcription factor; anti-sigma28 factor FlgM complement(1215821..1216114) Escherichia coli ED1a 7142123 YP_002397237.1 CDS flgA NC_011745.1 1216190 1216849 R required for the assembly of the flagellar basal body P-ring; flagellar basal body P-ring biosynthesis protein FlgA complement(1216190..1216849) Escherichia coli ED1a 7142122 YP_002397238.1 CDS flgB NC_011745.1 1217004 1217420 D with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella; flagellar basal body rod protein FlgB 1217004..1217420 Escherichia coli ED1a 7144198 YP_002397239.1 CDS flgC NC_011745.1 1217424 1217828 D with FlgF and B makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgC 1217424..1217828 Escherichia coli ED1a 7142027 YP_002397240.1 CDS flgD NC_011745.1 1217840 1218535 D acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production; flagellar basal body rod modification protein 1217840..1218535 Escherichia coli ED1a 7142112 YP_002397241.1 CDS flgE NC_011745.1 1218560 1219765 D the hook connects flagellar basal body to the flagellar filament; flagellar hook protein FlgE 1218560..1219765 Escherichia coli ED1a 7142113 YP_002397242.1 CDS flgF NC_011745.1 1219785 1220540 D FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgF 1219785..1220540 Escherichia coli ED1a 7142114 YP_002397243.1 CDS flgG NC_011745.1 1220712 1221494 D makes up the distal portion of the flagellar basal body rod; flagellar basal body rod protein FlgG 1220712..1221494 Escherichia coli ED1a 7142115 YP_002397244.1 CDS flgH NC_011745.1 1221547 1222245 D part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod; flagellar basal body L-ring protein 1221547..1222245 Escherichia coli ED1a 7142116 YP_002397245.1 CDS flgI NC_011745.1 1222257 1223354 D part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum; flagellar basal body P-ring protein 1222257..1223354 Escherichia coli ED1a 7142117 YP_002397246.1 CDS flgJ NC_011745.1 1223354 1224295 D Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space; flagellar rod assembly protein/muramidase FlgJ 1223354..1224295 Escherichia coli ED1a 7142118 YP_002397247.1 CDS flgK NC_011745.1 1224361 1226004 D with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook; flagellar hook-associated protein FlgK 1224361..1226004 Escherichia coli ED1a 7142119 YP_002397248.1 CDS flgL NC_011745.1 1226016 1226969 D with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of this and other flagellar genes; flagellar hook-associated protein FlgL 1226016..1226969 Escherichia coli ED1a 7142120 YP_002397249.1 CDS rne NC_011745.1 1227164 1230349 R bifunctional ribonuclease E/endoribonuclease/RNA-binding protein/RNA degradosome binding protein; forms part of the membrane-associated degradosome complex along with PNPase, RhlB, and enolase; ribonuclease E complement(1227164..1230349) Escherichia coli ED1a 7142121 YP_002397250.1 CDS rluC NC_011745.1 1230922 1231881 D catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA; 23S rRNA pseudouridylate synthase C 1230922..1231881 Escherichia coli ED1a 7140747 YP_002397251.1 CDS yceF NC_011745.1 1231993 1232577 R Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein complement(1231993..1232577) Escherichia coli ED1a 7141426 YP_002397252.1 CDS yceD NC_011745.1 1232776 1233297 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 90008815, 1447160; hypothetical protein 1232776..1233297 Escherichia coli ED1a 7143836 YP_002397253.1 CDS rpmF NC_011745.1 1233349 1233522 D some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 1233349..1233522 Escherichia coli ED1a 7142736 YP_002397254.1 CDS plsX NC_011745.1 1233603 1234673 D involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; putative glycerol-3-phosphate acyltransferase PlsX 1233603..1234673 Escherichia coli ED1a 7141480 YP_002397255.1 CDS fabH NC_011745.1 1234741 1235694 D FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-(acyl carrier protein) synthase III 1234741..1235694 Escherichia coli ED1a 7139071 YP_002397256.1 CDS fabD NC_011745.1 1235710 1236639 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92052166, 92183950, 92210530, 92234941, 7700236, 7768883, 9298646; Product type e : enzyme; malonyl-CoA-[acyl-carrier-protein] transacylase 1235710..1236639 Escherichia coli ED1a 7144120 YP_002397257.1 CDS fabG NC_011745.1 1236652 1237386 D catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-(acyl-carrier-protein) reductase 1236652..1237386 Escherichia coli ED1a 7144035 YP_002397258.1 CDS acpP NC_011745.1 1237597 1237833 D carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 1237597..1237833 Escherichia coli ED1a 7144119 YP_002397259.1 CDS fabF NC_011745.1 1237920 1239161 D FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase II 1237920..1239161 Escherichia coli ED1a 7143646 YP_002397260.1 CDS pabC NC_011745.1 1239281 1240090 D catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate; 4-amino-4-deoxychorismate lyase 1239281..1240090 Escherichia coli ED1a 7144118 YP_002397261.1 CDS yceG NC_011745.1 1240093 1241115 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 1240093..1241115 Escherichia coli ED1a 7144037 YP_002397262.1 CDS tmk NC_011745.1 1241105 1241746 D catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 1241105..1241746 Escherichia coli ED1a 7142738 YP_002397263.1 CDS holB NC_011745.1 1241743 1242747 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 1241743..1242747 Escherichia coli ED1a 7141562 YP_002397264.1 CDS ycfH NC_011745.1 1242758 1243555 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8505303, 8509334, 10747959; Product type pe : putative enzyme; putative metallodependent hydrolase 1242758..1243555 Escherichia coli ED1a 7139911 YP_002397265.1 CDS ptsG NC_011745.1 1243850 1245283 D phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system glucose-specific transporter subunits IIBC 1243850..1245283 Escherichia coli ED1a 7141946 YP_002397266.1 CDS fhuE NC_011745.1 1245343 1247532 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90286919, 3032906, 10529396; Product type t : transporter; ferric-rhodotorulic acid outer membrane transporter complement(1245343..1247532) Escherichia coli ED1a 7141206 YP_002397267.1 CDS hinT NC_011745.1 1247866 1248225 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15703176, 10493123, 2162465; Product type e : enzyme; purine nucleoside phosphoramidase 1247866..1248225 Escherichia coli ED1a 7144173 YP_002397268.1 CDS ycfL NC_011745.1 1248228 1248605 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1248228..1248605 Escherichia coli ED1a 7139884 YP_002397269.1 CDS ycfM NC_011745.1 1248619 1249260 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative outer membrane lipoprotein 1248619..1249260 Escherichia coli ED1a 7141948 YP_002397270.1 CDS thiK NC_011745.1 1249241 1250065 D catalyzes the phosphorylation of thiamine to thiamine phosphate; thiamine kinase 1249241..1250065 Escherichia coli ED1a 7141949 YP_002397271.1 CDS nagZ NC_011745.1 1250076 1251101 D hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides; beta-hexosaminidase 1250076..1251101 Escherichia coli ED1a 7141950 YP_002397272.1 CDS ycfP NC_011745.1 1251124 1251666 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1251124..1251666 Escherichia coli ED1a 7140341 YP_002397273.1 CDS ndh NC_011745.1 1252065 1253369 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14766919, 20130027, 81256452, 92296775, 94042945, 99441207, 6265208; Product type e : enzyme; respiratory NADH dehydrogenase 2/cupric reductase 1252065..1253369 Escherichia coli ED1a 7141951 YP_002397274.1 CDS ycfJ NC_011745.1 1253596 1254135 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6265208, 7984428; hypothetical protein 1253596..1254135 Escherichia coli ED1a 7140371 YP_002397275.1 CDS ycfQ NC_011745.1 1254197 1254829 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(1254197..1254829) Escherichia coli ED1a 7141947 YP_002397276.1 CDS ycfR NC_011745.1 1255070 1255327 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14727089; hypothetical protein 1255070..1255327 Escherichia coli ED1a 7141952 YP_002397277.1 CDS ycfS NC_011745.1 1255410 1256372 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1255410..1256372) Escherichia coli ED1a 7141953 YP_002397278.1 CDS mfd NC_011745.1 1256515 1259961 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14602898, 90158497, 92107993, 8465200; Product type f : factor; transcription-repair coupling factor complement(1256515..1259961) Escherichia coli ED1a 7141954 YP_002397279.1 CDS ycfT NC_011745.1 1260089 1261162 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1260089..1261162) Escherichia coli ED1a 7142263 YP_002397280.1 CDS lolC NC_011745.1 1261424 1262623 D part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolC 1261424..1262623 Escherichia coli ED1a 7141955 YP_002397281.1 CDS lolD NC_011745.1 1262616 1263317 D outer membrane specific; part of transporter complex lolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone; lipoprotein transporter ATP-binding subunit 1262616..1263317 Escherichia coli ED1a 7141902 YP_002397282.1 CDS lolE NC_011745.1 1263317 1264561 D part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolE 1263317..1264561 Escherichia coli ED1a 7141903 YP_002397283.1 CDS ycfX NC_011745.1 1264590 1265501 D catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine; N-acetyl-D-glucosamine kinase 1264590..1265501 Escherichia coli ED1a 7141904 YP_002397284.1 CDS cobB NC_011745.1 1265517 1266338 D Modulates the activities of several enzymes which are inactive in their acetylated form; NAD-dependent deacetylase 1265517..1266338 Escherichia coli ED1a 7141956 YP_002397285.1 CDS ycfZ NC_011745.1 1266464 1267252 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1266464..1267252) Escherichia coli ED1a 7142032 YP_002397286.1 CDS ymfA NC_011745.1 1267249 1267710 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1267249..1267710) Escherichia coli ED1a 7141957 YP_002397287.1 CDS potD NC_011745.1 1267768 1268814 R can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotD is a periplasmic component that binds the substrate; spermidine/putrescine ABC transporter periplasmic substrate-binding protein complement(1267768..1268814) Escherichia coli ED1a 7140977 YP_002397288.1 CDS potC NC_011745.1 1268811 1269605 R can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component; spermidine/putrescine ABC transporter membrane protein complement(1268811..1269605) Escherichia coli ED1a 7139086 YP_002397289.1 CDS potB NC_011745.1 1269602 1270429 R can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component; spermidine/putrescine ABC transporter membrane protein complement(1269602..1270429) Escherichia coli ED1a 7139085 YP_002397290.1 CDS potA NC_011745.1 1270443 1271579 R functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase; putrescine/spermidine ABC transporter ATPase protein complement(1270443..1271579) Escherichia coli ED1a 7139084 YP_002397291.1 CDS ECED1_1270 NC_011745.1 1271558 1271809 R Evidence 6 : Doubtful CDS; hypothetical protein complement(1271558..1271809) Escherichia coli ED1a 7139083 YP_002397292.1 CDS pepT NC_011745.1 1271829 1273055 D catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T 1271829..1273055 Escherichia coli ED1a 7142532 YP_002397293.1 CDS ycfD NC_011745.1 1273104 1274225 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1273104..1274225) Escherichia coli ED1a 7144065 YP_002397294.1 CDS phoQ NC_011745.1 1274301 1275761 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92105017; Product type r : regulator; sensor protein PhoQ complement(1274301..1275761) Escherichia coli ED1a 7141945 YP_002397295.1 CDS phoP NC_011745.1 1275761 1276432 R response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress; DNA-binding transcriptional regulator PhoP complement(1275761..1276432) Escherichia coli ED1a 7144107 YP_002397296.1 CDS purB NC_011745.1 1276601 1277971 R Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase complement(1276601..1277971) Escherichia coli ED1a 7144106 YP_002397297.1 CDS hflD NC_011745.1 1277975 1278616 R HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis; hypothetical protein complement(1277975..1278616) Escherichia coli ED1a 7141214 YP_002397298.1 CDS mnmA NC_011745.1 1278652 1279758 R catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA complement(1278652..1279758) Escherichia coli ED1a 7139879 YP_002397299.1 CDS ymfB NC_011745.1 1279812 1280273 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15292217; Product type e : enzyme; bifunctional thiamin pyrimidine pyrophosphate hydrolase and thiamin pyrophosphate hydrolase complement(1279812..1280273) Escherichia coli ED1a 7140818 YP_002397300.1 CDS ymfC NC_011745.1 1280283 1280936 R catalyzes the formation of pseudouridine from uracil-2457 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase E complement(1280283..1280936) Escherichia coli ED1a 7140978 YP_002397301.1 CDS icd NC_011745.1 1281108 1282358 D Converts isocitrate to alpha ketoglutarate; isocitrate dehydrogenase 1281108..1282358 Escherichia coli ED1a 7140979 YP_002397302.1 CDS insB NC_011745.1 1282795 1283298 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' complement(1282795..1283298) Escherichia coli ED1a 7141174 YP_002397303.1 CDS insA NC_011745.1 1283217 1283492 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA complement(1283217..1283492) Escherichia coli ED1a 7141140 YP_002397304.1 CDS ECED1_1284 NC_011745.1 1283543 1285537 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative side tail fiber protein from lambdoid prophage complement(1283543..1285537) Escherichia coli ED1a 7141117 YP_002397305.1 CDS insA NC_011745.1 1286469 1286744 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 1286469..1286744 Escherichia coli ED1a 7142535 YP_002397306.1 CDS insB NC_011745.1 1286663 1287166 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 1286663..1287166 Escherichia coli ED1a 7141118 YP_002397307.1 CDS insM NC_011745.1 1287376 1287678 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS600 1287376..1287678 Escherichia coli ED1a 7141141 YP_002397308.1 CDS ECED1_1290 NC_011745.1 1287714 1288532 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS600 1287714..1288532 Escherichia coli ED1a 7141165 YP_002397309.1 CDS ECED1_1291 NC_011745.1 1288438 1288809 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1288438..1288809 Escherichia coli ED1a 7142536 YP_002397310.1 CDS ECED1_1292 NC_011745.1 1288822 1289115 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1288822..1289115 Escherichia coli ED1a 7142537 YP_002397311.1 CDS sitD NC_011745.1 1289207 1290064 R Evidence 2b : Function of strongly homologous gene; PubMedId : 12654809, 10085045; Product type m : membrane component; iron transporter inner membrane component complement(1289207..1290064) Escherichia coli ED1a 7142538 YP_002397312.1 CDS sitC NC_011745.1 1290061 1290918 R Evidence 2b : Function of strongly homologous gene; PubMedId : 12654809, 10085045; Product type m : membrane component; iron transporter inner membrane component complement(1290061..1290918) Escherichia coli ED1a 7143801 YP_002397313.1 CDS sitB NC_011745.1 1290915 1291742 R Evidence 2b : Function of strongly homologous gene; PubMedId : 12654809, 10085045; Product type m : membrane component; iron transport protein, ATP-binding protein complement(1290915..1291742) Escherichia coli ED1a 7143800 YP_002397314.1 CDS sitA NC_011745.1 1291742 1292656 R Evidence 2b : Function of strongly homologous gene; PubMedId : 12654809, 10085045; Product type t : transporter; iron transport protein, periplasmic-binding protein complement(1291742..1292656) Escherichia coli ED1a 7143799 YP_002397315.1 CDS ECED1_1297 NC_011745.1 1293069 1293653 D Evidence 4 : Homologs of previously reported genes of unknown function; putative transcriptional regulator 1293069..1293653 Escherichia coli ED1a 7143798 YP_002397316.1 CDS ECED1_1298 NC_011745.1 1293678 1293965 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acetyltransferase (fragment) complement(1293678..1293965) Escherichia coli ED1a 7142539 YP_002397317.1 CDS ycgX NC_011745.1 1295009 1295413 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1295009..1295413) Escherichia coli ED1a 7140222 YP_002397318.1 CDS ycgE NC_011745.1 1295634 1296365 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(1295634..1296365) Escherichia coli ED1a 7141968 YP_002397319.1 CDS ycgF NC_011745.1 1296570 1297781 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16533062, 15453820; Product type pe : putative enzyme; putative blue-light sensing cyclic-di-GMP phosphodiesterase complement(1296570..1297781) Escherichia coli ED1a 7141959 YP_002397320.1 CDS ycgZ NC_011745.1 1298094 1298330 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1298094..1298330 Escherichia coli ED1a 7141960 YP_002397321.1 CDS ymgA NC_011745.1 1298373 1298645 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1298373..1298645 Escherichia coli ED1a 7141969 YP_002397322.1 CDS ymgB NC_011745.1 1298674 1298940 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1298674..1298940 Escherichia coli ED1a 7140981 YP_002397323.1 CDS ymgC NC_011745.1 1299053 1299301 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1299053..1299301 Escherichia coli ED1a 7140982 YP_002397324.1 CDS ymgF NC_011745.1 1300624 1300842 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1300624..1300842 Escherichia coli ED1a 7141961 YP_002397325.1 CDS ECED1_1310 NC_011745.1 1301240 1301419 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1301240..1301419 Escherichia coli ED1a 7140986 YP_002397326.1 CDS ECED1_1311 NC_011745.1 1301723 1302085 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1301723..1302085 Escherichia coli ED1a 7142541 YP_002397327.1 CDS ECED1_1312 NC_011745.1 1302231 1302758 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1302231..1302758 Escherichia coli ED1a 7142542 YP_002397328.1 CDS ymgD NC_011745.1 1302817 1303146 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1302817..1303146) Escherichia coli ED1a 7142543 YP_002397329.1 CDS ymgG NC_011745.1 1303156 1303431 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1303156..1303431) Escherichia coli ED1a 7140984 YP_002397330.1 CDS minE NC_011745.1 1304792 1305058 R works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell; cell division topological specificity factor MinE complement(1304792..1305058) Escherichia coli ED1a 7140304 YP_002397331.1 CDS minD NC_011745.1 1305062 1305874 R ATPase; with MinC inhibits cell division by blocking formation of the polar Z ring septums; cell division inhibitor MinD complement(1305062..1305874) Escherichia coli ED1a 7138986 YP_002397332.1 CDS minC NC_011745.1 1305898 1306593 R blocks the formation of polar Z-ring septums; septum formation inhibitor complement(1305898..1306593) Escherichia coli ED1a 7138985 YP_002397333.1 CDS ycgJ NC_011745.1 1307113 1307481 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1307113..1307481 Escherichia coli ED1a 7138984 YP_002397334.1 CDS ycgK NC_011745.1 1307601 1308002 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1307601..1308002) Escherichia coli ED1a 7141962 YP_002397335.1 CDS ycgL NC_011745.1 1308211 1308537 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1308211..1308537 Escherichia coli ED1a 7141963 YP_002397336.1 CDS ycgM NC_011745.1 1308609 1309268 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15551868; Product type pe : putative enzyme; hypothetical protein 1308609..1309268 Escherichia coli ED1a 7141964 YP_002397337.1 CDS ycgN NC_011745.1 1309360 1309806 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1309360..1309806 Escherichia coli ED1a 7141965 YP_002397338.1 CDS umuD NC_011745.1 1310605 1311024 D binds with UmuC protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuD 1310605..1311024 Escherichia coli ED1a 7140748 YP_002397339.1 CDS umuC NC_011745.1 1311024 1312286 D binds processed UmuD protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuC 1311024..1312286 Escherichia coli ED1a 7138976 YP_002397340.1 CDS dsbB NC_011745.1 1312331 1312861 R disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein; disulfide bond formation protein B complement(1312331..1312861) Escherichia coli ED1a 7138894 YP_002397341.1 CDS nhaB NC_011745.1 1313007 1314548 R involved in regulation of intracellular pH under alkaline conditions; sodium/proton antiporter complement(1313007..1314548) Escherichia coli ED1a 7140522 YP_002397342.1 CDS fadR NC_011745.1 1314770 1315489 D Multifunctional regulator of fatty acid metabolism; fatty acid metabolism regulator 1314770..1315489 Escherichia coli ED1a 7140383 YP_002397343.1 CDS ycgB NC_011745.1 1315652 1317184 R Evidence 4 : Homologs of previously reported genes of unknown function; SpoVR family protein complement(1315652..1317184) Escherichia coli ED1a 7144130 YP_002397344.1 CDS dadA NC_011745.1 1317514 1318812 D catalyzes the oxidative deamination of D-amino acids; D-amino acid dehydrogenase small subunit 1317514..1318812 Escherichia coli ED1a 7141958 YP_002397345.1 CDS dadX NC_011745.1 1318822 1319892 D catabolic enzyme, converts L-alanine to D-alanine which is then oxidized to pyruvate by dadA; alanine racemase 1318822..1319892 Escherichia coli ED1a 7143056 YP_002397346.1 CDS cvrA NC_011745.1 1319949 1321685 R the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli; potassium/proton antiporter complement(1319949..1321685) Escherichia coli ED1a 7143057 YP_002397347.1 CDS ldcA NC_011745.1 1321780 1322694 R catalyzes the release of D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine; L,D-carboxypeptidase A complement(1321780..1322694) Escherichia coli ED1a 7142092 YP_002397348.1 CDS emtA NC_011745.1 1322794 1323405 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98317285; Product type e : enzyme; lytic murein endotransglycosylase E 1322794..1323405 Escherichia coli ED1a 7141869 YP_002397349.1 CDS ycgR NC_011745.1 1323407 1324141 R Evidence 2b : Function of strongly homologous gene; PubMedId : 11031114; Product type cp : cell process; flagellar function protein complement(1323407..1324141) Escherichia coli ED1a 7139791 YP_002397350.1 CDS ymgE NC_011745.1 1324342 1324596 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative inner membrane protein with transglycosylase-associated domain 1324342..1324596 Escherichia coli ED1a 7141967 YP_002397351.1 CDS prrA NC_011745.1 1324646 1326637 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative outer membrane receptor, probably tonB dependent complement(1324646..1326637) Escherichia coli ED1a 7140985 YP_002397352.1 CDS modD NC_011745.1 1326642 1327496 R involved in molybdenum transport; molybdenum transport protein ModD complement(1326642..1327496) Escherichia coli ED1a 7141186 YP_002397353.1 CDS ECED1_1340 NC_011745.1 1327493 1328305 R Evidence 4 : Homologs of previously reported genes of unknown function; putative SAM-dependent methyltransferase complement(1327493..1328305) Escherichia coli ED1a 7139006 YP_002397354.1 CDS ECED1_1341 NC_011745.1 1328315 1329073 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ABC transporter ATP-binding protein complement(1328315..1329073) Escherichia coli ED1a 7142544 YP_002397355.1 CDS ECED1_1342 NC_011745.1 1329070 1330050 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative ABC transporter permease complement(1329070..1330050) Escherichia coli ED1a 7142545 YP_002397356.1 CDS ECED1_1343 NC_011745.1 1330050 1331114 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter periplasmic binding protein complement(1330050..1331114) Escherichia coli ED1a 7142546 YP_002397357.1 CDS dhaH NC_011745.1 1333425 1334843 R phosphotransferaese subunit; phosphorylates dihydroxyacetone along with DhaK/DhaL; dihydroxyacetone kinase subunit M complement(1333425..1334843) Escherichia coli ED1a 7140804 YP_002397358.1 CDS dhaL NC_011745.1 1334854 1335486 R with DhaK and DhaM catalyzes the phosphorylation of dihydroxyacetone; dihydroxyacetone kinase subunit DhaL complement(1334854..1335486) Escherichia coli ED1a 7143110 YP_002397359.1 CDS dhaK NC_011745.1 1335497 1336567 R with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase; dihydroxyacetone kinase subunit DhaK complement(1335497..1336567) Escherichia coli ED1a 7143112 YP_002397360.1 CDS dhaR NC_011745.1 1336795 1338714 D Positively regulates the dhaKLM operon from a sigma-70 promoter; DNA-binding transcriptional regulator DhaR 1336795..1338714 Escherichia coli ED1a 7143111 YP_002397361.1 CDS ECED1_1350 NC_011745.1 1338751 1338981 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1338751..1338981) Escherichia coli ED1a 7143113 YP_002397362.1 CDS ychF NC_011745.1 1339119 1340210 R translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD complement(1339119..1340210) Escherichia coli ED1a 7142548 YP_002397363.1 CDS pth NC_011745.1 1340327 1340911 R Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase complement(1340327..1340911) Escherichia coli ED1a 7141972 YP_002397364.1 CDS ychH NC_011745.1 1341189 1341467 D YchH; transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria; ychH presents a class II promoter to bind CRP; unknown function; hypothetical protein 1341189..1341467 Escherichia coli ED1a 7141202 YP_002397365.1 CDS ychM NC_011745.1 1341522 1343201 R putative role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport; putative sulfate transporter YchM complement(1341522..1343201) Escherichia coli ED1a 7141973 YP_002397366.1 CDS prsA NC_011745.1 1343326 1344273 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase complement(1343326..1344273) Escherichia coli ED1a 7141975 YP_002397367.1 CDS ipk NC_011745.1 1344424 1345275 R An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase complement(1344424..1345275) Escherichia coli ED1a 7141187 YP_002397368.1 CDS lolB NC_011745.1 1345275 1345898 R Incorporates lipoproteins in the outer membrane after they are released by the LolA protein; outer membrane lipoprotein LolB complement(1345275..1345898) Escherichia coli ED1a 7142465 YP_002397369.1 CDS hemA NC_011745.1 1346114 1347370 D catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 1346114..1347370 Escherichia coli ED1a 7141901 YP_002397370.1 CDS prfA NC_011745.1 1347412 1348494 D recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 1347412..1348494 Escherichia coli ED1a 7139865 YP_002397371.1 CDS prmC NC_011745.1 1348494 1349327 D HemK; PrmC; transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 1348494..1349327 Escherichia coli ED1a 7139115 YP_002397372.1 CDS ychQ NC_011745.1 1349324 1349716 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10322010; Product type pr : putative regulator; putative transcriptional regulator 1349324..1349716 Escherichia coli ED1a 7139126 YP_002397373.1 CDS ychA NC_011745.1 1349720 1350529 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10322010; Product type pr : putative regulator; putative transcriptional regulator 1349720..1350529 Escherichia coli ED1a 7141978 YP_002397374.1 CDS kdsA NC_011745.1 1350565 1351419 D catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 1350565..1351419 Escherichia coli ED1a 7141970 YP_002397375.1 CDS ldrB NC_011745.1 1351568 1351675 R Evidence 1b : Function experimentally demonstrated in the studied species; Product type f : factor; toxic polypeptide, small complement(1351568..1351675) Escherichia coli ED1a 7142498 YP_002397376.1 CDS chaA NC_011745.1 1352080 1353180 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93266586, 94193576, 94292460; Product type t : transporter; calcium/sodium:proton antiporter complement(1352080..1353180) Escherichia coli ED1a 7140749 YP_002397377.1 CDS chaB NC_011745.1 1353450 1353680 D in Escherichia coli this protein putatively regulates the sodium/proton (also pH-independent calcium/proton) antiporter chaA; has weak affinity for calcium and magnesium ions; cation transport regulator 1353450..1353680 Escherichia coli ED1a 7139329 YP_002397378.1 CDS chaC NC_011745.1 1353817 1354533 D Evidence 1b : Function experimentally demonstrated in the studied species; Product type r : regulator; regulatory protein for cation transport 1353817..1354533 Escherichia coli ED1a 7139330 YP_002397379.1 CDS ychN NC_011745.1 1354577 1354930 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1354577..1354930) Escherichia coli ED1a 7139331 YP_002397380.1 CDS ychP NC_011745.1 1355256 1356509 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7567469; Product type pf : putative factor; hypothetical protein 1355256..1356509 Escherichia coli ED1a 7141976 YP_002397381.1 CDS narL NC_011745.1 1356510 1357160 R two-component response regulator NarL; phosphorylated by NarQ; activates transcription of nitrate and nitrite reductase genes and represses transcription of fumarate reductase; transcriptional regulator NarL complement(1356510..1357160) Escherichia coli ED1a 7141977 YP_002397382.1 CDS narX NC_011745.1 1357153 1358949 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92276349, 92374842, 94083940, 2649492, 2657652, 2668029; Product type r : regulator; nitrate/nitrite sensor protein NarX complement(1357153..1358949) Escherichia coli ED1a 7140362 YP_002397383.1 CDS ECED1_1372 NC_011745.1 1358975 1359193 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1358975..1359193 Escherichia coli ED1a 7140368 YP_002397384.1 CDS narK NC_011745.1 1359288 1360679 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91258310, 2657652, 2668029; Product type t : transporter; nitrate/nitrite transporter 1359288..1360679 Escherichia coli ED1a 7142549 YP_002397385.1 CDS narG NC_011745.1 1361072 1364815 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 74167294, 89384449, 92121125, 2233673, 2668029, 2995309, 3053688, 3308846, 6094247; Product type e : enzyme; nitrate reductase 1 subunit alpha 1361072..1364815 Escherichia coli ED1a 7140361 YP_002397386.1 CDS narH NC_011745.1 1364812 1366350 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 74167294, 89384449, 92121125, 1321049, 2832376, 3053688, 8383531, 8388253, 8664273, 9516445; Product type c : carrier; nitrate reductase 1, beta (Fe-S) subunit 1364812..1366350 Escherichia coli ED1a 7140357 YP_002397387.1 CDS narJ NC_011745.1 1366347 1367057 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89384449, 92121125, 9632249, 2832376; Product type f : factor; nitrate reductase 1 minormolybdenum-cofactor-assembly chaperone 1366347..1367057 Escherichia coli ED1a 7140358 YP_002397388.1 CDS narI NC_011745.1 1367057 1367734 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 75114694, 89384449, 92121125, 2832376, 3053688; Product type c : carrier; nitrate reductase 1, gamma (cytochrome b(NR)) subunit 1367057..1367734 Escherichia coli ED1a 7140360 YP_002397389.1 CDS ECED1_1379 NC_011745.1 1368148 1368300 D Evidence 6 : Doubtful CDS; hypothetical protein 1368148..1368300 Escherichia coli ED1a 7142550 YP_002397390.1 CDS purU NC_011745.1 1369780 1370622 R produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; formyltetrahydrofolate deformylase complement(1369780..1370622) Escherichia coli ED1a 7140628 YP_002397391.1 CDS ychJ NC_011745.1 1370672 1371130 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1370672..1371130) Escherichia coli ED1a 7141226 YP_002397392.1 CDS rssA NC_011745.1 1371204 1372148 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 1371204..1372148 Escherichia coli ED1a 7141974 YP_002397393.1 CDS rssB NC_011745.1 1372240 1373253 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339606, 12912910, 9495753; Product type r : regulator; response regulator of RpoS 1372240..1373253 Escherichia coli ED1a 7140119 YP_002397394.1 CDS galU NC_011745.1 1373455 1374363 D together with GalF subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; UTP--glucose-1-phosphate uridylyltransferase subunit GalU 1373455..1374363 Escherichia coli ED1a 7140120 YP_002397395.1 CDS hns NC_011745.1 1374507 1374920 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89056689, 94335643, 95267838, 95286558, 99355427, 2404280, 11298273; Product type r : regulator; global DNA-binding transcriptional dual regulator H-NS complement(1374507..1374920) Escherichia coli ED1a 7143156 YP_002397396.1 CDS tdk NC_011745.1 1375524 1376141 D catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 1375524..1376141 Escherichia coli ED1a 7139904 YP_002397397.1 CDS adhE NC_011745.1 1377589 1380264 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12783863, 4301680, 89291706, 91200315; Product type e : enzyme; bifunctional acetaldehyde-CoA/alcohol dehydrogenase complement(1377589..1380264) Escherichia coli ED1a 7141161 YP_002397398.1 CDS ychE NC_011745.1 1380741 1381388 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1380741..1381388 Escherichia coli ED1a 7143660 YP_002397399.1 CDS ECED1_1394 NC_011745.1 1381546 1381860 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1381546..1381860) Escherichia coli ED1a 7141971 YP_002397400.1 CDS oppA NC_011745.1 1382126 1383757 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20256410, 86111605, 90256748, 92325017, 2015910, 9298646, 9600841, 2187863, 8740179, 9740056, 10972807; Product type t : transporter; oligopeptide ABC transporter subunit periplasmic-binding protein 1382126..1383757 Escherichia coli ED1a 7142555 YP_002397401.1 CDS oppB NC_011745.1 1383843 1384763 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86111606, 93106975, 2187863; Product type t : transporter; oligopeptide transporter permease 1383843..1384763 Escherichia coli ED1a 7139981 YP_002397402.1 CDS oppC NC_011745.1 1384778 1385686 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86111606; Product type t : transporter; oligopeptide ABC transporter membrane protein 1384778..1385686 Escherichia coli ED1a 7139982 YP_002397403.1 CDS oppD NC_011745.1 1385698 1386711 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86111606; Product type t : transporter; oligopeptide transporter ATP-binding protein 1385698..1386711 Escherichia coli ED1a 7139983 YP_002397404.1 CDS oppF NC_011745.1 1386708 1387712 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86111606; Product type t : transporter; oligopeptide ABC transporter ATP-binding protein 1386708..1387712 Escherichia coli ED1a 7139984 YP_002397405.1 CDS yciU NC_011745.1 1387765 1388094 R highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein; dsDNA-mimic protein complement(1387765..1388094) Escherichia coli ED1a 7139985 YP_002397406.1 CDS cls NC_011745.1 1388129 1389589 R catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol); cardiolipin synthetase complement(1388129..1389589) Escherichia coli ED1a 7141990 YP_002397407.1 CDS ECED1_1402 NC_011745.1 1389621 1389905 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1389621..1389905 Escherichia coli ED1a 7139379 YP_002397408.1 CDS kch NC_011745.1 1389960 1391213 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12220501, 12912904, 94224769, 98319474; Product type t : transporter; voltage-gated potassium channel complement(1389960..1391213) Escherichia coli ED1a 7142556 YP_002397409.1 CDS yciI NC_011745.1 1391513 1391809 R unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity; YciI-like protein complement(1391513..1391809) Escherichia coli ED1a 7142489 YP_002397410.1 CDS tonB NC_011745.1 1391982 1392749 D membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins; transport protein TonB 1391982..1392749 Escherichia coli ED1a 7141983 YP_002397411.1 CDS yciA NC_011745.1 1392789 1393187 R YciA; hydrolase that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA; member of the the acyl coenzyme A hydrolase family of proteins; acyl-CoA thioester hydrolase complement(1392789..1393187) Escherichia coli ED1a 7140651 YP_002397412.1 CDS yciB NC_011745.1 1393293 1393832 R Involved in cell division; probably involved in intracellular septation; intracellular septation protein A complement(1393293..1393832) Escherichia coli ED1a 7141979 YP_002397413.1 CDS yciC NC_011745.1 1393862 1394605 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1393862..1394605) Escherichia coli ED1a 7141980 YP_002397414.1 CDS ompW NC_011745.1 1394960 1395598 D receptor for colicin S4; outer membrane protein W 1394960..1395598 Escherichia coli ED1a 7141981 YP_002397415.1 CDS ECED1_1411 NC_011745.1 1395644 1396774 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; phage integrase complement(1395644..1396774) Escherichia coli ED1a 7139976 YP_002397416.1 CDS ECED1_1412 NC_011745.1 1396752 1397000 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; phage excisionase complement(1396752..1397000) Escherichia coli ED1a 7142557 YP_002397417.1 CDS ECED1_1414 NC_011745.1 1397427 1397930 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1849492, 12770720; Product type h : extrachromosomal origin; Insertion element IS1 1/5/6 protein insB complement(1397427..1397930) Escherichia coli ED1a 7142559 YP_002397418.1 CDS insA NC_011745.1 1397849 1398124 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; Transposase ORF A, IS1 complement(1397849..1398124) Escherichia coli ED1a 7142560 YP_002397419.1 CDS ECED1_1416 NC_011745.1 1398276 1398452 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1398276..1398452 Escherichia coli ED1a 7141119 YP_002397420.1 CDS ECED1_1417 NC_011745.1 1398449 1398964 D Evidence 4 : Homologs of previously reported genes of unknown function; putative prophage protein 1398449..1398964 Escherichia coli ED1a 7142561 YP_002397421.1 CDS rem NC_011745.1 1399895 1400146 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2990907; Product type h : extrachromosomal origin; hypothetical protein 1399895..1400146 Escherichia coli ED1a 7142562 YP_002397422.1 CDS ydfU NC_011745.1 1400493 1401542 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1400493..1401542 Escherichia coli ED1a 7141587 YP_002397423.1 CDS ECED1_1420 NC_011745.1 1401555 1401929 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative crossover junction endodeoxyribonuclease RusA 1401555..1401929 Escherichia coli ED1a 7139270 YP_002397424.1 CDS ECED1_1421 NC_011745.1 1401926 1402747 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative antitermination protein Q of prophage 1401926..1402747 Escherichia coli ED1a 7142563 YP_002397425.1 CDS ECED1_1422 NC_011745.1 1402887 1403171 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1402887..1403171 Escherichia coli ED1a 7142564 YP_002397426.1 CDS ECED1_1426 NC_011745.1 1405815 1407803 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1405815..1407803 Escherichia coli ED1a 7142568 YP_002397427.1 CDS ECED1_1427 NC_011745.1 1407988 1408452 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1407988..1408452 Escherichia coli ED1a 7142569 YP_002397428.1 CDS essD NC_011745.1 1408528 1408743 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage lysis protein S 1408528..1408743 Escherichia coli ED1a 7142570 YP_002397429.1 CDS ECED1_1429 NC_011745.1 1408748 1409737 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1408748..1409737 Escherichia coli ED1a 7139812 YP_002397430.1 CDS ydfQ NC_011745.1 1409774 1410307 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-associated lysozyme; Qin prophage 1409774..1410307 Escherichia coli ED1a 7142571 YP_002397431.1 CDS ECED1_1431 NC_011745.1 1410385 1410597 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1410385..1410597 Escherichia coli ED1a 7139265 YP_002397432.1 CDS ECED1_1432 NC_011745.1 1410578 1410850 D Evidence 6 : Doubtful CDS; hypothetical protein 1410578..1410850 Escherichia coli ED1a 7142572 YP_002397433.1 CDS rz NC_011745.1 1410866 1411444 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Endopeptidase (Lysis protein) from bacteriophage origin 1410866..1411444 Escherichia coli ED1a 7142573 YP_002397434.1 CDS ECED1_1435 NC_011745.1 1411441 1411665 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1411441..1411665 Escherichia coli ED1a 7141358 YP_002397435.1 CDS ECED1_1436 NC_011745.1 1411626 1411901 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1411626..1411901 Escherichia coli ED1a 7142574 YP_002397436.1 CDS ECED1_1438 NC_011745.1 1411995 1412336 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative tonB-like membrane protein from phage origin 1411995..1412336 Escherichia coli ED1a 7142575 YP_002397437.1 CDS ynfO NC_011745.1 1412468 1412668 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(1412468..1412668) Escherichia coli ED1a 7142576 YP_002397438.1 CDS ECED1_1440 NC_011745.1 1412710 1413075 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative endonuclease from phage origin 1412710..1413075 Escherichia coli ED1a 7141016 YP_002397439.1 CDS ECED1_1441 NC_011745.1 1413367 1413930 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative terminase small subunit from phage origin 1413367..1413930 Escherichia coli ED1a 7142577 YP_002397440.1 CDS ECED1_1442 NC_011745.1 1413927 1415588 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative terminase large subunit from phage origin 1413927..1415588 Escherichia coli ED1a 7142578 YP_002397441.1 CDS ECED1_1443 NC_011745.1 1415652 1417589 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative major head protein/prohead protease from phage origin 1415652..1417589 Escherichia coli ED1a 7142579 YP_002397442.1 CDS ECED1_1444 NC_011745.1 1417634 1417855 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1417634..1417855 Escherichia coli ED1a 7142026 YP_002397443.1 CDS ECED1_1445 NC_011745.1 1417801 1419165 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; phage portal protein, HK97 family 1417801..1419165 Escherichia coli ED1a 7142746 YP_002397444.1 CDS ECED1_1446 NC_011745.1 1419162 1420385 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage portal protein 1419162..1420385 Escherichia coli ED1a 7142747 YP_002397445.1 CDS ECED1_1447 NC_011745.1 1420382 1420708 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1420382..1420708 Escherichia coli ED1a 7142748 YP_002397446.1 CDS ECED1_1448 NC_011745.1 1420718 1421068 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; head-tail adaptor from phage origin 1420718..1421068 Escherichia coli ED1a 7142749 YP_002397447.1 CDS ECED1_1449 NC_011745.1 1421044 1421511 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative structural component HK97 gp of phage origin 1421044..1421511 Escherichia coli ED1a 7142750 YP_002397448.1 CDS ECED1_1450 NC_011745.1 1421508 1421852 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative structural component of phage origin 1421508..1421852 Escherichia coli ED1a 7142751 YP_002397449.1 CDS ECED1_1451 NC_011745.1 1421919 1422635 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative major tail subunit of phage origin 1421919..1422635 Escherichia coli ED1a 7142752 YP_002397450.1 CDS ECED1_1452 NC_011745.1 1422641 1423015 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative tail assembly protein of phage origin 1422641..1423015 Escherichia coli ED1a 7142753 YP_002397451.1 CDS ECED1_1453 NC_011745.1 1423039 1423320 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1423039..1423320 Escherichia coli ED1a 7142754 YP_002397452.1 CDS ECED1_1454 NC_011745.1 1423368 1426610 D Evidence 2b : Function of strongly homologous gene; PubMedId : 11686382, 11282477, 9562894, 8878031; Product type f : factor; tail length tape measure protein 1423368..1426610 Escherichia coli ED1a 7142755 YP_002397453.1 CDS ECED1_1455 NC_011745.1 1426603 1426944 D Evidence 2b : Function of strongly homologous gene; PubMedId : 11686382, 11282477, 9562894, 8878031; Product type f : factor; minor tail protein M 1426603..1426944 Escherichia coli ED1a 7142756 YP_002397454.1 CDS ECED1_1456 NC_011745.1 1427151 1428314 D Evidence 2b : Function of strongly homologous gene; Product type t : transporter; outer membrane porin protein from phage origin 1427151..1428314 Escherichia coli ED1a 7142757 YP_002397455.1 CDS ECED1_1457 NC_011745.1 1428504 1429208 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein L 1428504..1429208 Escherichia coli ED1a 7142758 YP_002397456.1 CDS ECED1_1459 NC_011745.1 1428958 1429962 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail fiber component K 1428958..1429962 Escherichia coli ED1a 7142759 YP_002397457.1 CDS ECED1_1460 NC_011745.1 1429860 1430540 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail assembly protein I 1429860..1430540 Escherichia coli ED1a 7142760 YP_002397458.1 CDS ECED1_1463 NC_011745.1 1433250 1433849 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative Lom-like outer membrane protein of phage origin 1433250..1433849 Escherichia coli ED1a 7142763 YP_002397459.1 CDS ECED1_1464 NC_011745.1 1434001 1435509 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative tail fiber protein from phage origin 1434001..1435509 Escherichia coli ED1a 7142764 YP_002397460.1 CDS ECED1_1465 NC_011745.1 1435529 1436107 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1435529..1436107 Escherichia coli ED1a 7142765 YP_002397461.1 CDS ECED1_1466 NC_011745.1 1436140 1436436 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(1436140..1436436) Escherichia coli ED1a 7142766 YP_002397462.1 CDS trpA NC_011745.1 1436760 1437566 R catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha complement(1436760..1437566) Escherichia coli ED1a 7142767 YP_002397463.1 CDS trpB NC_011745.1 1437566 1438759 R catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta complement(1437566..1438759) Escherichia coli ED1a 7140819 YP_002397464.1 CDS trpC NC_011745.1 1438771 1440129 R monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate; bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase complement(1438771..1440129) Escherichia coli ED1a 7140820 YP_002397465.1 CDS trpD NC_011745.1 1440133 1441728 R bifunctional anthranilate synthase II/anthranilate phosphoribosyltransferase; TrpD; forms a heterotetramer with Trp E and the complex catalyzes the formation of anthranilate from chorismate and glutamine; also catalyzes the formation of N-(5-phospho-D-ribosyl)-anthranilate from athranilate and 5-phospho-alpha-D-ribose 1-diphosphate; functions in tryptophan biosynthesis; bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase complement(1440133..1441728) Escherichia coli ED1a 7140821 YP_002397466.1 CDS trpE NC_011745.1 1441728 1443290 R with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I complement(1441728..1443290) Escherichia coli ED1a 7140822 YP_002397468.1 CDS yciV NC_011745.1 1443564 1444445 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1443564..1444445 Escherichia coli ED1a 7140824 YP_002397469.1 CDS yciO NC_011745.1 1444442 1445062 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1444442..1445062 Escherichia coli ED1a 7141991 YP_002397470.1 CDS yciQ NC_011745.1 1445087 1446979 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1445087..1446979 Escherichia coli ED1a 7141987 YP_002397471.1 CDS rluB NC_011745.1 1447192 1448067 D catalyzes the synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA; 23S rRNA pseudouridylate synthase B 1447192..1448067 Escherichia coli ED1a 7141988 YP_002397472.1 CDS btuR NC_011745.1 1448107 1448697 R catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide; cob(I)yrinic acid a,c-diamide adenosyltransferase complement(1448107..1448697) Escherichia coli ED1a 7141425 YP_002397473.1 CDS yciK NC_011745.1 1448694 1449452 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; short chain dehydrogenase complement(1448694..1449452) Escherichia coli ED1a 7140469 YP_002397474.1 CDS sohB NC_011745.1 1449672 1450721 D SohB; periplasmic protein; member of the peptidase S49 family; putative periplasmic protease 1449672..1450721 Escherichia coli ED1a 7141984 YP_002397475.1 CDS yciN NC_011745.1 1450757 1451008 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3029379, 7567469, 9868784; hypothetical protein complement(1450757..1451008) Escherichia coli ED1a 7143818 YP_002397476.1 CDS ECED1_1480 NC_011745.1 1451001 1451156 D Evidence 6 : Doubtful CDS; hypothetical protein 1451001..1451156 Escherichia coli ED1a 7141986 YP_002397477.1 CDS topA NC_011745.1 1451388 1453985 D catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 1451388..1453985 Escherichia coli ED1a 7142768 YP_002397478.1 CDS cysB NC_011745.1 1454195 1455169 D LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation; transcriptional regulator CysB 1454195..1455169 Escherichia coli ED1a 7140790 YP_002397479.1 CDS ECED1_1483 NC_011745.1 1455464 1455628 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1455464..1455628 Escherichia coli ED1a 7142108 YP_002397480.1 CDS ECED1_1484 NC_011745.1 1455610 1455798 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1455610..1455798 Escherichia coli ED1a 7142769 YP_002397481.1 CDS ribA NC_011745.1 1458895 1459485 R catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate; GTP cyclohydrolase II complement(1458895..1459485) Escherichia coli ED1a 7143643 YP_002397482.1 CDS pgpB NC_011745.1 1459655 1460419 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89033893, 92104964; Product type e : enzyme; phosphatidylglycerophosphatase B 1459655..1460419 Escherichia coli ED1a 7141621 YP_002397483.1 CDS yciS NC_011745.1 1460568 1460876 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1460568..1460876 Escherichia coli ED1a 7144079 YP_002397484.1 CDS yciM NC_011745.1 1460883 1462052 D Evidence 4 : Homologs of previously reported genes of unknown function; tetratricopeptide repeat protein 1460883..1462052 Escherichia coli ED1a 7141989 YP_002397485.1 CDS pyrF NC_011745.1 1462244 1462981 D type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 1462244..1462981 Escherichia coli ED1a 7141985 YP_002397486.1 CDS yciH NC_011745.1 1462981 1463307 D involved in start site selection during the initiation of translation; translation initiation factor Sui1 1462981..1463307 Escherichia coli ED1a 7141235 YP_002397487.1 CDS osmB NC_011745.1 1463433 1463651 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92078100, 2644204; Product type lp : lipoprotein; lipoprotein complement(1463433..1463651) Escherichia coli ED1a 7141982 YP_002397488.1 CDS deoT NC_011745.1 1463920 1464669 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16451192; Product type r : regulator; DeoR family DNA-binding transcriptional repressor complement(1463920..1464669) Escherichia coli ED1a 7139987 YP_002397489.1 CDS ECED1_1495 NC_011745.1 1464759 1464941 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1464759..1464941) Escherichia coli ED1a 7143098 YP_002397490.1 CDS gmr NC_011745.1 1465080 1467065 R c-di-GMP phosphodiesterase; probably degrades signalling molecule c-di-GMP; RNase II stability modulator complement(1465080..1467065) Escherichia coli ED1a 7142771 YP_002397491.1 CDS rnb NC_011745.1 1467299 1469230 R Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction; exoribonuclease II complement(1467299..1469230) Escherichia coli ED1a 7142996 YP_002397492.1 CDS yciW NC_011745.1 1469298 1470425 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative amidase or amidotransferase complement(1469298..1470425) Escherichia coli ED1a 7141431 YP_002397493.1 CDS fabI NC_011745.1 1470570 1471358 R Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-(acyl carrier protein) reductase complement(1470570..1471358) Escherichia coli ED1a 7141992 YP_002397494.1 CDS ECED1_1500 NC_011745.1 1471737 1472402 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional repressor 1471737..1472402 Escherichia coli ED1a 7144121 YP_002397495.1 CDS ECED1_1501 NC_011745.1 1472518 1473672 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative efflux protein, membrane fusion (MFP) family 1472518..1473672 Escherichia coli ED1a 7142772 YP_002397496.1 CDS ECED1_1502 NC_011745.1 1473672 1476779 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative efflux pump 1473672..1476779 Escherichia coli ED1a 7142773 YP_002397497.1 CDS ECED1_1503 NC_011745.1 1476783 1478156 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative outer membrane channel protein of an efflux system 1476783..1478156 Escherichia coli ED1a 7142774 YP_002397498.1 CDS ECED1_1504 NC_011745.1 1478165 1479328 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 1478165..1479328 Escherichia coli ED1a 7142775 YP_002397499.1 CDS sapF NC_011745.1 1479376 1480182 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 10720487, 9634580; Product type t : transporter; antimicrobial peptide ABC transporter ATP-binding protein complement(1479376..1480182) Escherichia coli ED1a 7142776 YP_002397500.1 CDS sapD NC_011745.1 1480184 1481176 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 10720487, 9634580, 1987159; Product type t : transporter; antimicrobial peptide ABC transporter ATP-binding protein complement(1480184..1481176) Escherichia coli ED1a 7141368 YP_002397501.1 CDS sapC NC_011745.1 1481176 1482066 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 9634580; Product type t : transporter; antimicrobial peptide ABC transporter permease complement(1481176..1482066) Escherichia coli ED1a 7141367 YP_002397502.1 CDS sapB NC_011745.1 1482053 1483018 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 9634580; Product type t : transporter; antimicrobial peptide ABC transporter permease complement(1482053..1483018) Escherichia coli ED1a 7141366 YP_002397503.1 CDS sapA NC_011745.1 1483015 1484658 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 9634580; Product type t : transporter; antimicrobial peptide ABC transporter periplasmic-binding protein complement(1483015..1484658) Escherichia coli ED1a 7141365 YP_002397504.1 CDS ymjA NC_011745.1 1484971 1485216 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1484971..1485216) Escherichia coli ED1a 7141364 YP_002397505.1 CDS pspF NC_011745.1 1485643 1486620 R transcriptional activator for pspABCE which are induced in response to phage proteins, membrane altering stresses, and impaired proton expor; phage shock protein operon transcriptional activator complement(1485643..1486620) Escherichia coli ED1a 7140988 YP_002397506.1 CDS pspA NC_011745.1 1486786 1487454 D involved in maintaining membrane potential under membrane stress conditions; also acts as a negative transcriptional regulator of the phage shock protein (psp) operon(pspABCDE) by regulating the transcriptional activator PspF; phage shock protein PspA 1486786..1487454 Escherichia coli ED1a 7141195 YP_002397507.1 CDS pspB NC_011745.1 1487508 1487732 D acts together with PspC to induce psp operon during infection with phage, exposure to ethanol or osmotic shock; forms a complex with PspA and C; PspC is required for PspAB binding; phage shock protein B 1487508..1487732 Escherichia coli ED1a 7141190 YP_002397508.1 CDS pspC NC_011745.1 1487732 1488091 D with PsbB forms toxin/antitoxin pair; activates the psp operon in response to phage infection, exposure to ethanol or osmotic shock; DNA-binding transcriptional activator PspC 1487732..1488091 Escherichia coli ED1a 7141191 YP_002397509.1 CDS pspD NC_011745.1 1488100 1488321 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91295203, 97303082; Product type ph : phenotype; peripheral inner membrane phage-shock protein 1488100..1488321 Escherichia coli ED1a 7141192 YP_002397510.1 CDS pspE NC_011745.1 1488396 1488710 D rhodanese; catalyzes the formation of thiocyanate from thiosulfate and hydrogen cyanide; thiosulfate:cyanide sulfurtransferase 1488396..1488710 Escherichia coli ED1a 7141193 YP_002397511.1 CDS ycjM NC_011745.1 1488920 1490599 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glucosyltransferase 1488920..1490599 Escherichia coli ED1a 7141194 YP_002397512.1 CDS ycjN NC_011745.1 1490613 1491905 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter periplasmic-binding protein transporter 1490613..1491905 Escherichia coli ED1a 7141995 YP_002397513.1 CDS ycjO NC_011745.1 1491926 1492807 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter permease 1491926..1492807 Escherichia coli ED1a 7141996 YP_002397514.1 CDS ycjP NC_011745.1 1492794 1493636 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter permease 1492794..1493636 Escherichia coli ED1a 7141997 YP_002397515.1 CDS ycjQ NC_011745.1 1493667 1494719 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase, Zn-dependent and NAD(P)-binding 1493667..1494719 Escherichia coli ED1a 7141998 YP_002397516.1 CDS ycjR NC_011745.1 1494738 1495526 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative isomerase/epimerase 1494738..1495526 Escherichia coli ED1a 7141999 YP_002397517.1 CDS ycjS NC_011745.1 1495536 1496591 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase, NADH-binding 1495536..1496591 Escherichia coli ED1a 7142000 YP_002397518.1 CDS ycjT NC_011745.1 1496588 1498855 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glycosyl hydrolase/phosphorylase 1496588..1498855 Escherichia coli ED1a 7142001 YP_002397519.1 CDS ycjU NC_011745.1 1498852 1499511 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11972617; Product type pe : putative enzyme; putative glucose-1-phosphate phosphodismutase 1498852..1499511 Escherichia coli ED1a 7142002 YP_002397520.1 CDS ycjV NC_011745.1 1499525 1500607 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter ATP-binding protein transporter 1499525..1500607 Escherichia coli ED1a 7142003 YP_002397521.1 CDS ompG NC_011745.1 1500652 1501557 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20464934, 89327119, 9721282; Product type t : transporter; outer membrane porin 1500652..1501557 Escherichia coli ED1a 7142004 YP_002397522.1 CDS ycjW NC_011745.1 1501608 1502606 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(1501608..1502606) Escherichia coli ED1a 7139970 YP_002397523.1 CDS ycjX NC_011745.1 1502763 1504160 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1502763..1504160 Escherichia coli ED1a 7142005 YP_002397524.1 CDS ycjF NC_011745.1 1504157 1505218 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1504157..1505218 Escherichia coli ED1a 7142006 YP_002397525.1 CDS tyrR NC_011745.1 1505366 1506907 D regulates genes involved in the biosynthesis and transport of aromatic amino acids; DNA-binding transcriptional regulator TyrR 1505366..1506907 Escherichia coli ED1a 7141993 YP_002397526.1 CDS tpx NC_011745.1 1506951 1507457 R antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase complement(1506951..1507457) Escherichia coli ED1a 7140853 YP_002397527.1 CDS ycjG NC_011745.1 1507576 1508541 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11747447, 11747448, 7499381; Product type e : enzyme; L-Ala-D/L-Glu epimerase 1507576..1508541 Escherichia coli ED1a 7140801 YP_002397528.1 CDS mpaA NC_011745.1 1508516 1509304 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12511517; Product type e : enzyme; murein peptide amidase A complement(1508516..1509304) Escherichia coli ED1a 7141994 YP_002397529.1 CDS ymjC NC_011745.1 1509535 1510173 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative NAD(P) binding enzyme complement(1509535..1510173) Escherichia coli ED1a 7139014 YP_002397530.1 CDS ycjZ NC_011745.1 1511301 1512200 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 17366475; Product type pr : putative regulator; putative nucleic acid-binding regulator 1511301..1512200 Escherichia coli ED1a 7142009 YP_002397531.1 CDS mppA NC_011745.1 1512537 1514150 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10438753, 9495761; Product type t : transporter; murein tripeptide (L-ala-gamma-D-glutamyl-meso-DAP) ABC transporter subunit periplasmic-binding protein 1512537..1514150 Escherichia coli ED1a 7142010 YP_002397532.1 CDS ynaI NC_011745.1 1514201 1515232 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1514201..1515232) Escherichia coli ED1a 7139016 YP_002397533.1 CDS ynaJ NC_011745.1 1515476 1515733 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1515476..1515733 Escherichia coli ED1a 7140990 YP_002397534.1 CDS uspE NC_011745.1 1515783 1516733 R with UspC and UspD is involved in resistance to UV irradiation; universal stress protein UspE complement(1515783..1516733) Escherichia coli ED1a 7140991 YP_002397535.1 CDS fnr NC_011745.1 1516885 1517637 R Global transcription factor that controls the expression of over 100 target genes in response to anoxia; fumarate/nitrate reduction transcriptional regulator complement(1516885..1517637) Escherichia coli ED1a 7139146 YP_002397536.1 CDS ogt NC_011745.1 1517832 1518347 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88067749, 91161525, 94252990, 98125595, 1520330; Product type e : enzyme; O-6-alkylguanine-DNA:cysteine-protein methyltransferase complement(1517832..1518347) Escherichia coli ED1a 7142153 YP_002397537.1 CDS ECED1_1546 NC_011745.1 1518358 1518549 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1518358..1518549) Escherichia coli ED1a 7139966 YP_002397538.1 CDS ECED1_1547 NC_011745.1 1518879 1519694 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative HTH-type transcriptional regulator complement(1518879..1519694) Escherichia coli ED1a 7140750 YP_002397539.1 CDS ECED1_1548 NC_011745.1 1519788 1520819 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative HlyD family secretion protein 1519788..1520819 Escherichia coli ED1a 7142778 YP_002397540.1 CDS ECED1_1549 NC_011745.1 1520816 1522330 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative drug resistance transporter EmrB/QacA subfamily 1520816..1522330 Escherichia coli ED1a 7142779 YP_002397541.1 CDS ydaL NC_011745.1 1522525 1523088 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1522525..1523088 Escherichia coli ED1a 7142780 YP_002397542.1 CDS ydaM NC_011745.1 1523109 1524341 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16045609; Product type pe : putative enzyme; putative diguanylate cyclase, GG[D/E]EF domain signalling protein complement(1523109..1524341) Escherichia coli ED1a 7142011 YP_002397543.1 CDS zntB NC_011745.1 1524596 1525579 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; zinc transporter 1524596..1525579 Escherichia coli ED1a 7142012 YP_002397544.1 CDS ECED1_1553 NC_011745.1 1525854 1526027 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1525854..1526027 Escherichia coli ED1a 7142013 YP_002397545.1 CDS dbpA NC_011745.1 1526057 1527430 D exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA; ATP-dependent RNA helicase DbpA 1526057..1527430 Escherichia coli ED1a 7140472 YP_002397546.1 CDS ydaO NC_011745.1 1527559 1528494 R TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs; C32 tRNA thiolase complement(1527559..1528494) Escherichia coli ED1a 7143067 YP_002397547.1 CDS ECED1_1557 NC_011745.1 1530364 1530732 R Evidence 4 : Homologs of previously reported genes of unknown function; putative ABC transporter complement(1530364..1530732) Escherichia coli ED1a 7142444 YP_002397548.1 CDS uspF NC_011745.1 1530821 1531255 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12732303, 12381839, 11849540, 9298646; Product type f : factor; stress-induced protein, ATP-binding protein complement(1530821..1531255) Escherichia coli ED1a 7142782 YP_002397549.1 CDS ydbK NC_011745.1 1532895 1536419 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9025293; Product type pe : putative enzyme; putative 2-oxoacid-flavodoxin/oxidoreductase complement(1532895..1536419) Escherichia coli ED1a 7138982 YP_002397550.1 CDS ydbJ NC_011745.1 1536693 1536959 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1536693..1536959 Escherichia coli ED1a 7142021 YP_002397551.1 CDS hslJ NC_011745.1 1536956 1537378 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12892888, 8349564, 9025293; Product type f : factor; heat-inducible protein complement(1536956..1537378) Escherichia coli ED1a 7142020 YP_002397552.1 CDS ldhA NC_011745.1 1537489 1538478 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 4297266, 89123040, 90198524, 8349564, 9025293; Product type e : enzyme; fermentative D-lactate dehydrogenase, NAD-dependent complement(1537489..1538478) Escherichia coli ED1a 7140166 YP_002397553.1 CDS ydbH NC_011745.1 1538686 1541325 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1538686..1541325 Escherichia coli ED1a 7141871 YP_002397554.1 CDS ynbE NC_011745.1 1541322 1541507 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; putative lipoprotein 1541322..1541507 Escherichia coli ED1a 7142019 YP_002397555.1 CDS ydbL NC_011745.1 1541515 1541841 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1541515..1541841 Escherichia coli ED1a 7140992 YP_002397556.1 CDS ydbA NC_011745.1 1542217 1549209 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative cell adhesion autotransported outer membrane protein 1542217..1549209 Escherichia coli ED1a 7142022 YP_002397557.1 CDS ydbC NC_011745.1 1549428 1550294 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 1549428..1550294 Escherichia coli ED1a 7142017 YP_002397558.1 CDS azoR NC_011745.1 1550335 1550940 R FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds; azoreductase complement(1550335..1550940) Escherichia coli ED1a 7142018 YP_002397559.1 CDS hrpA NC_011745.1 1551198 1555043 D involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain; ATP-dependent RNA helicase HrpA 1551198..1555043 Escherichia coli ED1a 7140425 YP_002397560.1 CDS ydcF NC_011745.1 1555316 1556116 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1555316..1556116 Escherichia coli ED1a 7139916 YP_002397561.1 CDS aldA NC_011745.1 1556313 1557752 D NAD-linked; aldehyde dehydrogenase A 1556313..1557752 Escherichia coli ED1a 7142025 YP_002397562.1 CDS gapC NC_011745.1 1557794 1558795 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9622357, 9019141, 1917845, 3780374; Product type e : enzyme; glyceraldehyde-3-phosphate dehydrogenase C complement(1557794..1558795) Escherichia coli ED1a 7143686 YP_002397563.1 CDS cybB NC_011745.1 1558984 1559514 D B-type di-heme cytochrome with a major alpha-absorption peak at 561 nm and a minor peak at 555 nm; cytochrome b561 1558984..1559514 Escherichia coli ED1a 7143158 YP_002397564.1 CDS ydcA NC_011745.1 1559759 1559932 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1559759..1559932 Escherichia coli ED1a 7140152 YP_002397565.1 CDS ydcI NC_011745.1 1560597 1561520 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(1560597..1561520) Escherichia coli ED1a 7140809 YP_002397566.1 CDS ydcJ NC_011745.1 1561737 1563080 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1561737..1563080 Escherichia coli ED1a 7139224 YP_002397567.1 CDS mdoD NC_011745.1 1563335 1564960 D involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans; glucan biosynthesis protein D 1563335..1564960 Escherichia coli ED1a 7139225 YP_002397568.1 CDS ECED1_1581 NC_011745.1 1564881 1565084 R Evidence 6 : Doubtful CDS; hypothetical protein complement(1564881..1565084) Escherichia coli ED1a 7142224 YP_002397569.1 CDS ydcH NC_011745.1 1565100 1565324 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1565100..1565324 Escherichia coli ED1a 7142783 YP_002397570.1 CDS rimL NC_011745.1 1565387 1565926 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89364711; Product type e : enzyme; ribosomal-protein-L7/L12-serine acetyltransferase 1565387..1565926 Escherichia coli ED1a 7139223 YP_002397571.1 CDS ydcK NC_011745.1 1565918 1566898 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein complement(1565918..1566898) Escherichia coli ED1a 7141419 YP_002397572.1 CDS tehA NC_011745.1 1567022 1568014 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94222856, 2060788; Product type t : transporter; potassium-tellurite ethidium and proflavin transporter 1567022..1568014 Escherichia coli ED1a 7139226 YP_002397573.1 CDS tehB NC_011745.1 1568011 1568604 D with TehA confers resistance to tellurite; tellurite resistance protein TehB 1568011..1568604 Escherichia coli ED1a 7141532 YP_002397574.1 CDS ydcL NC_011745.1 1568907 1569575 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; putative lipoprotein 1568907..1569575 Escherichia coli ED1a 7141533 YP_002397575.1 CDS ydcO NC_011745.1 1569610 1570788 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1885518; Product type pt : putative transporter; putative benzoate transporter complement(1569610..1570788) Escherichia coli ED1a 7139227 YP_002397576.1 CDS ydcN NC_011745.1 1570874 1571410 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1570874..1571410 Escherichia coli ED1a 7139230 YP_002397577.1 CDS ydcP NC_011745.1 1571483 1573444 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative peptidase 1571483..1573444 Escherichia coli ED1a 7139229 YP_002397578.1 CDS yncJ NC_011745.1 1573536 1573766 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1573536..1573766) Escherichia coli ED1a 7139231 YP_002397579.1 CDS ydcR NC_011745.1 1574260 1575666 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15223311; Product type pr : putative regulator; putative DNA-binding transcriptional regulator fused with a domain with PLP-binding motif 1574260..1575666 Escherichia coli ED1a 7139232 YP_002397580.1 CDS ydcS NC_011745.1 1575911 1577056 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11683869; Product type pt : putative transporter; putative spermidine/putrescine ABC transporter subunit periplasmic-binding protein transporter 1575911..1577056 Escherichia coli ED1a 7139233 YP_002397581.1 CDS ydcT NC_011745.1 1577074 1578087 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative spermidine/putrescine ABC transporter ATP-binding protein 1577074..1578087 Escherichia coli ED1a 7139234 YP_002397582.1 CDS ydcU NC_011745.1 1578088 1579029 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative spermidine/putrescine ABC transporter permease 1578088..1579029 Escherichia coli ED1a 7139235 YP_002397583.1 CDS ydcV NC_011745.1 1579019 1579813 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative spermidine/putrescine ABC transporter permease 1579019..1579813 Escherichia coli ED1a 7139236 YP_002397584.1 CDS ydcW NC_011745.1 1579835 1581259 D catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation; gamma-aminobutyraldehyde dehydrogenase 1579835..1581259 Escherichia coli ED1a 7139237 YP_002397585.1 CDS ydcX NC_011745.1 1581573 1581821 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1581573..1581821 Escherichia coli ED1a 7139238 YP_002397586.1 CDS ydcY NC_011745.1 1581907 1582140 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1581907..1582140 Escherichia coli ED1a 7139239 YP_002397587.1 CDS ydcZ NC_011745.1 1582141 1582590 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1582141..1582590) Escherichia coli ED1a 7139240 YP_002397588.1 CDS yncA NC_011745.1 1582587 1583105 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acyl-CoA N-acyltransferase domain-containing acyltransferase complement(1582587..1583105) Escherichia coli ED1a 7139241 YP_002397589.1 CDS ECED1_1603 NC_011745.1 1583314 1583550 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1583314..1583550 Escherichia coli ED1a 7140993 YP_002397590.1 CDS yncD NC_011745.1 1583588 1585690 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative iron outer membrane receptor complement(1583588..1585690) Escherichia coli ED1a 7142784 YP_002397591.1 CDS yncE NC_011745.1 1585932 1586993 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1585932..1586993 Escherichia coli ED1a 7140994 YP_002397592.1 CDS ansP NC_011745.1 1587106 1588605 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 76005443; Product type t : transporter; L-asparagine transporter complement(1587106..1588605) Escherichia coli ED1a 7140995 YP_002397593.1 CDS ECED1_1610 NC_011745.1 1590333 1592738 D Evidence 4 : Homologs of previously reported genes of unknown function; putative VgrG/E protein associated with Rhs elements 1590333..1592738 Escherichia coli ED1a 7140998 YP_002397594.1 CDS ECED1_1611 NC_011745.1 1592692 1593519 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative zinc-dependent metallopeptidase 1592692..1593519 Escherichia coli ED1a 7142785 YP_002397595.1 CDS ECED1_1612 NC_011745.1 1593543 1594328 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1593543..1594328 Escherichia coli ED1a 7142786 YP_002397596.1 CDS ECED1_1614 NC_011745.1 1594662 1594877 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1594662..1594877 Escherichia coli ED1a 7142024 YP_002397597.1 CDS yddH NC_011745.1 1595194 1595763 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1595194..1595763) Escherichia coli ED1a 7142788 YP_002397598.1 CDS nhoA NC_011745.1 1595938 1596783 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20267568; Product type e : enzyme; N-hydroxyarylamine O-acetyltransferase 1595938..1596783 Escherichia coli ED1a 7139244 YP_002397599.1 CDS yddE NC_011745.1 1596879 1597772 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14611652, 15103639, 2233673; hypothetical protein complement(1596879..1597772) Escherichia coli ED1a 7140385 YP_002397600.1 CDS narV NC_011745.1 1597852 1598532 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91042410; Product type e : enzyme; nitrate reductase 2 (NRZ) subunit gamma complement(1597852..1598532) Escherichia coli ED1a 7139242 YP_002397601.1 CDS narW NC_011745.1 1598529 1599224 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91042410, 92186712; Product type f : factor; nitrate reductase 2 (NRZ) subunit delta complement(1598529..1599224) Escherichia coli ED1a 7140366 YP_002397602.1 CDS narY NC_011745.1 1599224 1600768 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91042410; Product type c : carrier; nitrate reductase 2 (NRZ) subunit beta complement(1599224..1600768) Escherichia coli ED1a 7140367 YP_002397603.1 CDS narZ NC_011745.1 1600765 1604505 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91042410; Product type e : enzyme; nitrate reductase 2 (NRZ) subunit alpha complement(1600765..1604505) Escherichia coli ED1a 7140369 YP_002397604.1 CDS narU NC_011745.1 1604600 1605988 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95266795, 2233673; Product type t : transporter; nitrate/nitrite transporter complement(1604600..1605988) Escherichia coli ED1a 7140370 YP_002397605.1 CDS yddG NC_011745.1 1606261 1607085 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12410826; Product type t : transporter; hypothetical protein complement(1606261..1607085) Escherichia coli ED1a 7140365 YP_002397606.1 CDS fdnG NC_011745.1 1607374 1610421 D Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; formate dehydrogenase-N subunit alpha, nitrate-inducible 1607374..1610421 Escherichia coli ED1a 7139243 YP_002397607.1 CDS fdnH NC_011745.1 1610434 1611318 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 76005553, 90375017, 92332427, 11884747, 1834669; Product type c : carrier; formate dehydrogenase-N, Fe-S subunit beta, nitrate-inducible 1610434..1611318 Escherichia coli ED1a 7144139 YP_002397608.1 CDS fdnI NC_011745.1 1611311 1611964 D nitrate-inducible, cytochrome b556(fdn) component of formate dehydrogenase; formate dehydrogenase-N subunit gamma 1611311..1611964 Escherichia coli ED1a 7144140 YP_002397609.1 CDS ECED1_1630 NC_011745.1 1612473 1612751 R Evidence 4 : Homologs of previously reported genes of unknown function; putative plasmid maintenance system killer protein complement(1612473..1612751) Escherichia coli ED1a 7139245 YP_002397610.1 CDS adhP NC_011745.1 1612937 1613947 R similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase complement(1612937..1613947) Escherichia coli ED1a 7142789 YP_002397611.1 CDS sfcA NC_011745.1 1614081 1615778 R malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase complement(1614081..1615778) Escherichia coli ED1a 7143661 YP_002397612.1 CDS bdm NC_011745.1 1616174 1616389 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10498711, 13129944; Product type f : factor; biofilm-dependent modulation protein complement(1616174..1616389) Escherichia coli ED1a 7141403 YP_002397613.1 CDS osmC NC_011745.1 1616734 1617165 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14512736, 91350191, 9298646; Product type m : membrane component; osmotically inducible, stress-inducible membrane protein 1616734..1617165 Escherichia coli ED1a 7140442 YP_002397614.1 CDS dos NC_011745.1 1617355 1619754 R heme-regulated phosphodiesterase with phosphodiesterase activity with cAMP but not with cGMP, bis(p-nitrophenyl) phosphate or p-nitrophenyl phosphate; cAMP phosphodiesterase complement(1617355..1619754) Escherichia coli ED1a 7139988 YP_002397615.1 CDS yddW NC_011745.1 1620321 1621640 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10960106; Product type lp : lipoprotein; putative lipoprotein complement(1620321..1621640) Escherichia coli ED1a 7139246 YP_002397616.1 CDS gadC NC_011745.1 1621771 1623306 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15795232, 15489450; Product type t : transporter; glutamate:gamma-aminobutyric acid antiporter complement(1621771..1623306) Escherichia coli ED1a 7139247 YP_002397617.1 CDS gadB NC_011745.1 1623462 1624862 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12912902, 92155241, 92394884, 99406302, 8455549; Product type e : enzyme; glutamate decarboxylase B, PLP-dependent complement(1623462..1624862) Escherichia coli ED1a 7143143 YP_002397618.1 CDS ydeM NC_011745.1 1626487 1627644 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pr : putative regulator; hypothetical protein complement(1626487..1627644) Escherichia coli ED1a 7139113 YP_002397619.1 CDS ydeN NC_011745.1 1627696 1629378 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sulfatase complement(1627696..1629378) Escherichia coli ED1a 7139251 YP_002397620.1 CDS ydeO NC_011745.1 1629780 1630541 R regulates the cellular response to acid resistance; transcriptional regulator YdeO complement(1629780..1630541) Escherichia coli ED1a 7139252 YP_002397621.1 CDS ECED1_1644 NC_011745.1 1630617 1630850 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1630617..1630850) Escherichia coli ED1a 7139253 YP_002397622.1 CDS ydeP NC_011745.1 1631062 1633341 R in Escherichia coli it may be involved in repression of type III secretion system (TTSS) genes of the host cell; involved with increased resistance to low pH; member of the prokaryotic molybdopterin-containing oxidoreductase family; putative oxidoreductase complement(1631062..1633341) Escherichia coli ED1a 7142790 YP_002397623.1 CDS ydeT NC_011745.1 1634039 1634887 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1634039..1634887) Escherichia coli ED1a 7139255 YP_002397624.1 CDS ECED1_1648 NC_011745.1 1634890 1635177 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(1634890..1635177) Escherichia coli ED1a 7139256 YP_002397625.1 CDS hipA NC_011745.1 1635538 1636860 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91358364, 94292428, 15576765; Product type r : regulator; regulator with hipB complement(1635538..1636860) Escherichia coli ED1a 7142791 YP_002397626.1 CDS hipB NC_011745.1 1636860 1637126 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91358364, 94292428, 15576765, 8021189; Product type r : regulator; DNA-binding transcriptional regulator HipB complement(1636860..1637126) Escherichia coli ED1a 7139885 YP_002397627.1 CDS uxaB NC_011745.1 1638417 1639904 R catalyzes the formation of D-tagaturonate from D-altronate; altronate oxidoreductase complement(1638417..1639904) Escherichia coli ED1a 7141001 YP_002397628.1 CDS yneI NC_011745.1 1639968 1641356 R in Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase; putative succinate semialdehyde dehydrogenase complement(1639968..1641356) Escherichia coli ED1a 7139156 YP_002397629.1 CDS yneJ NC_011745.1 1641457 1642338 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1641457..1642338 Escherichia coli ED1a 7141002 YP_002397630.1 CDS ydeA NC_011745.1 1642677 1643867 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10094697, 99369894, 8383113, 10438792; Product type t : transporter; sugar efflux transporter 1642677..1643867 Escherichia coli ED1a 7141003 YP_002397631.1 CDS marC NC_011745.1 1643892 1644557 R protein involved in resistance to different drugs (tetracycline, chloramphenicol, beta-lactams, and quinolones); part of the multiple antibiotic resistance (mar) locus, which is composed by the genes marC and marRAB; unknown function; multiple drug resistance protein MarC complement(1643892..1644557) Escherichia coli ED1a 7139248 YP_002397632.1 CDS marR NC_011745.1 1644769 1645203 D Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes; DNA-binding transcriptional repressor MarR 1644769..1645203 Escherichia coli ED1a 7142214 YP_002397633.1 CDS marA NC_011745.1 1645224 1645607 D transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype; also activates sodA, zwf and micF; DNA-binding transcriptional activator MarA 1645224..1645607 Escherichia coli ED1a 7142215 YP_002397634.1 CDS marB NC_011745.1 1645639 1645857 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8383113; hypothetical protein 1645639..1645857 Escherichia coli ED1a 7142212 YP_002397635.1 CDS celA NC_011745.1 1645914 1647383 R converts 6-phospho-beta-D-glucosyl-(1,4)-D-glucose to glucose and glucose 6-phosphate; required for cellobiose uptake and metabolism; 6-phospho-beta-glucosidase complement(1645914..1647383) Escherichia coli ED1a 7142213 YP_002397636.1 CDS eamA NC_011745.1 1647837 1648736 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20305052; Product type t : transporter; O-acetylserine/cysteine export protein complement(1647837..1648736) Escherichia coli ED1a 7142793 YP_002397637.1 CDS ydeE NC_011745.1 1648931 1650118 D YdeF; uncharacterized member of the major facilitator superfamily (MFS) of transporters; putative MFS-type transporter YdeE 1648931..1650118 Escherichia coli ED1a 7139763 YP_002397638.1 CDS ydeH NC_011745.1 1650560 1651450 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1650560..1651450) Escherichia coli ED1a 7139249 YP_002397639.1 CDS dcp NC_011745.1 1651957 1654002 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 216006, 8226676; Product type e : enzyme; dipeptidyl carboxypeptidase II complement(1651957..1654002) Escherichia coli ED1a 7139250 YP_002397640.1 CDS ydfG NC_011745.1 1654139 1654885 D NADP(+)-dependent; catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine; 3-hydroxy acid dehydrogenase 1654139..1654885 Escherichia coli ED1a 7143070 YP_002397641.1 CDS ydfH NC_011745.1 1654974 1655660 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1654974..1655660 Escherichia coli ED1a 7139258 YP_002397642.1 CDS ydfZ NC_011745.1 1655837 1656040 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12084818; Product type pc : putative carrier; putative selenium carrying protein 1655837..1656040 Escherichia coli ED1a 7139259 YP_002397643.1 CDS ydfI NC_011745.1 1656076 1657536 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative mannonate dehydrogenase complement(1656076..1657536) Escherichia coli ED1a 7139272 YP_002397644.1 CDS ECED1_1672 NC_011745.1 1658161 1658979 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS600 complement(1658161..1658979) Escherichia coli ED1a 7139261 YP_002397645.1 CDS insM NC_011745.1 1659015 1659317 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS600 complement(1659015..1659317) Escherichia coli ED1a 7142794 YP_002397646.1 CDS ECED1_1675 NC_011745.1 1660202 1660546 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative damage-inducible protein from phage origin (dinI-like) 1660202..1660546 Escherichia coli ED1a 7139262 YP_002397647.1 CDS eaaA NC_011745.1 1660913 1664938 R Evidence 2b : Function of strongly homologous gene; PubMedId : 10722621, 17220264, 9194704, 9743528; Product type e : enzyme; peptidase S6, IgA endopeptidase from phage origin complement(1660913..1664938) Escherichia coli ED1a 7142795 YP_002397648.1 CDS ECED1_1677 NC_011745.1 1665212 1665682 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10722621; hypothetical protein complement(1665212..1665682) Escherichia coli ED1a 7139760 YP_002397649.1 CDS eibA NC_011745.1 1665770 1666954 R Evidence 2b : Function of strongly homologous gene; PubMedId : 16988252, 10722621; Product type f : factor; Immunoglobulin-binding protein from phage origin complement(1665770..1666954) Escherichia coli ED1a 7142796 YP_002397650.1 CDS ECED1_1679 NC_011745.1 1667636 1668214 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1667636..1668214) Escherichia coli ED1a 7139778 YP_002397651.1 CDS ECED1_1681 NC_011745.1 1668235 1669716 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative tail fiber protein from prophage complement(1668235..1669716) Escherichia coli ED1a 7142797 YP_002397652.1 CDS J NC_011745.1 1669901 1673431 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Host specificity protein J (tail component) from prophage complement(1669901..1673431) Escherichia coli ED1a 7142798 YP_002397653.1 CDS ECED1_1683 NC_011745.1 1673671 1674351 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail assembly protein I complement(1673671..1674351) Escherichia coli ED1a 7142480 YP_002397654.1 CDS ECED1_1684 NC_011745.1 1674249 1674986 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail fiber component K complement(1674249..1674986) Escherichia coli ED1a 7142799 YP_002397655.1 CDS ECED1_1685 NC_011745.1 1675041 1675955 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type f : factor; putative antirepressor protein from phage origin complement(1675041..1675955) Escherichia coli ED1a 7142800 YP_002397656.1 CDS ECED1_1687 NC_011745.1 1676245 1676517 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7999761, 10426954; Product type pr : putative regulator; putative regulatory protein (mnt like) 1676245..1676517 Escherichia coli ED1a 7142802 YP_002397657.1 CDS ECED1_1688 NC_011745.1 1676517 1677053 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative Clp protease 1676517..1677053 Escherichia coli ED1a 7142803 YP_002397658.1 CDS ECED1_1689 NC_011745.1 1677110 1677862 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein L complement(1677110..1677862) Escherichia coli ED1a 7142804 YP_002397659.1 CDS ECED1_1690 NC_011745.1 1678005 1679168 R Evidence 2b : Function of strongly homologous gene; Product type t : transporter; outer membrane porin protein from phage origin complement(1678005..1679168) Escherichia coli ED1a 7142805 YP_002397660.1 CDS ECED1_1691 NC_011745.1 1679375 1679716 R Evidence 2b : Function of strongly homologous gene; PubMedId : 11686382, 11282477, 9562894, 8878031; Product type f : factor; minor tail protein M complement(1679375..1679716) Escherichia coli ED1a 7142806 YP_002397661.1 CDS ECED1_1692 NC_011745.1 1679709 1682951 R Evidence 2b : Function of strongly homologous gene; Product type f : factor; tail component measure protein in prophage complement(1679709..1682951) Escherichia coli ED1a 7142807 YP_002397662.1 CDS ECED1_1693 NC_011745.1 1683015 1683428 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1683015..1683428) Escherichia coli ED1a 7142808 YP_002397663.1 CDS ECED1_1694 NC_011745.1 1683492 1683773 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1683492..1683773) Escherichia coli ED1a 7142809 YP_002397664.1 CDS ECED1_1695 NC_011745.1 1683797 1684219 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative tail assembly protein in prophage complement(1683797..1684219) Escherichia coli ED1a 7142810 YP_002397665.1 CDS ECED1_1696 NC_011745.1 1684186 1684902 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative major tail subunit in prophage complement(1684186..1684902) Escherichia coli ED1a 7142811 YP_002397666.1 CDS ECED1_1697 NC_011745.1 1684969 1685313 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1684969..1685313) Escherichia coli ED1a 7142812 YP_002397667.1 CDS ECED1_1698 NC_011745.1 1685310 1685756 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative structural component in prophage complement(1685310..1685756) Escherichia coli ED1a 7142813 YP_002397668.1 CDS ECED1_1699 NC_011745.1 1685753 1686103 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative head-tail adaptor in prophage complement(1685753..1686103) Escherichia coli ED1a 7142814 YP_002397669.1 CDS ECED1_1700 NC_011745.1 1686113 1686439 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1686113..1686439) Escherichia coli ED1a 7142815 YP_002397670.1 CDS ECED1_1701 NC_011745.1 1686436 1687659 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1686436..1687659) Escherichia coli ED1a 7142823 YP_002397671.1 CDS ECED1_1702 NC_011745.1 1687656 1689020 R Evidence 2b : Function of strongly homologous gene; Product type s : structure; phage portal protein complement(1687656..1689020) Escherichia coli ED1a 7142824 YP_002397672.1 CDS ECED1_1703 NC_011745.1 1688966 1689187 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1688966..1689187) Escherichia coli ED1a 7142825 YP_002397673.1 CDS ECED1_1704 NC_011745.1 1689232 1691169 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative major head protein/prohead protease in prophage complement(1689232..1691169) Escherichia coli ED1a 7142194 YP_002397674.1 CDS ECED1_1705 NC_011745.1 1691233 1692894 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative large subunit terminase in prophage complement(1691233..1692894) Escherichia coli ED1a 7143440 YP_002397675.1 CDS ECED1_1706 NC_011745.1 1692891 1693454 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative terminase small subunit in prophage complement(1692891..1693454) Escherichia coli ED1a 7143441 YP_002397676.1 CDS ECED1_1707 NC_011745.1 1693744 1694109 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative endonuclease from phage origin complement(1693744..1694109) Escherichia coli ED1a 7143442 YP_002397677.1 CDS ECED1_1708 NC_011745.1 1694091 1694351 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1694091..1694351 Escherichia coli ED1a 7143443 YP_002397678.1 CDS ECED1_1709 NC_011745.1 1694483 1694824 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative tonB-like membrane protein from phage origin complement(1694483..1694824) Escherichia coli ED1a 7143444 YP_002397679.1 CDS ECED1_1710 NC_011745.1 1694745 1695098 R Evidence 6 : Doubtful CDS; Product type h : extrachromosomal origin; hypothetical protein complement(1694745..1695098) Escherichia coli ED1a 7143445 YP_002397680.1 CDS ECED1_1711 NC_011745.1 1695243 1695500 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1695243..1695500) Escherichia coli ED1a 7143446 YP_002397681.1 CDS ECED1_1712 NC_011745.1 1695497 1696063 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(1695497..1696063) Escherichia coli ED1a 7143447 YP_002397682.1 CDS ECED1_1713 NC_011745.1 1696193 1696522 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(1696193..1696522) Escherichia coli ED1a 7143448 YP_002397683.1 CDS ECED1_1714 NC_011745.1 1696497 1696727 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(1696497..1696727) Escherichia coli ED1a 7143449 YP_002397684.1 CDS rz NC_011745.1 1696869 1697420 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Endopeptidase (Lysis protein) from bacteriophage origin complement(1696869..1697420) Escherichia coli ED1a 7143450 YP_002397685.1 CDS ECED1_1718 NC_011745.1 1697555 1697872 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1697555..1697872) Escherichia coli ED1a 7141359 YP_002397686.1 CDS ECED1_1719 NC_011745.1 1697781 1698476 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative antirepressor in prophage complement(1697781..1698476) Escherichia coli ED1a 7143451 YP_002397687.1 CDS ydfQ NC_011745.1 1698750 1699283 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-associated lysozyme; Qin prophage complement(1698750..1699283) Escherichia coli ED1a 7143452 YP_002397688.1 CDS ECED1_1721 NC_011745.1 1699603 1700112 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1699603..1700112) Escherichia coli ED1a 7139266 YP_002397689.1 CDS essD NC_011745.1 1700150 1700332 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage lysis protein S complement(1700150..1700332) Escherichia coli ED1a 7143453 YP_002397690.1 CDS ECED1_1723 NC_011745.1 1700408 1700872 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(1700408..1700872) Escherichia coli ED1a 7139813 YP_002397691.1 CDS ECED1_1724 NC_011745.1 1700931 1701104 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(1700931..1701104) Escherichia coli ED1a 7143454 YP_002397692.1 CDS ECED1_1725 NC_011745.1 1701058 1703046 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1701058..1703046) Escherichia coli ED1a 7143455 YP_002397693.1 CDS ECED1_1726 NC_011745.1 1703573 1704160 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1703573..1704160) Escherichia coli ED1a 7143456 YP_002397694.1 CDS ECED1_1727 NC_011745.1 1704102 1704422 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(1704102..1704422) Escherichia coli ED1a 7143457 YP_002397695.1 CDS ECED1_1728 NC_011745.1 1704742 1705431 R Evidence 2b : Function of strongly homologous gene; PubMedId : 3624233; Product type r : regulator; antitermination protein Q complement(1704742..1705431) Escherichia coli ED1a 7143458 YP_002397696.1 CDS ECED1_1729 NC_011745.1 1705422 1705781 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative crossover junction endodeoxyribonuclease RusA complement(1705422..1705781) Escherichia coli ED1a 7143459 YP_002397697.1 CDS ydfU NC_011745.1 1705794 1706843 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(1705794..1706843) Escherichia coli ED1a 7143460 YP_002397698.1 CDS ECED1_1731 NC_011745.1 1707683 1708369 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1707683..1708369) Escherichia coli ED1a 7139271 YP_002397699.1 CDS ECED1_1733 NC_011745.1 1708523 1708933 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(1708523..1708933) Escherichia coli ED1a 7143461 YP_002397700.1 CDS ECED1_1735 NC_011745.1 1708934 1709677 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1708934..1709677) Escherichia coli ED1a 7143462 YP_002397701.1 CDS ECED1_1736 NC_011745.1 1709693 1710358 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative replication protein in prophage complement(1709693..1710358) Escherichia coli ED1a 7143463 YP_002397702.1 CDS ECED1_1737 NC_011745.1 1710147 1711193 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1710147..1711193) Escherichia coli ED1a 7143464 YP_002397703.1 CDS ECED1_1738 NC_011745.1 1711256 1711681 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(1711256..1711681) Escherichia coli ED1a 7143465 YP_002397704.1 CDS ECED1_1739 NC_011745.1 1711665 1711946 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1711665..1711946) Escherichia coli ED1a 7143466 YP_002397705.1 CDS ECED1_1740 NC_011745.1 1712047 1712466 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1712047..1712466 Escherichia coli ED1a 7143467 YP_002397706.1 CDS ECED1_1741 NC_011745.1 1712539 1712883 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1712539..1712883 Escherichia coli ED1a 7143468 YP_002397707.1 CDS ECED1_1742 NC_011745.1 1712982 1713428 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1712982..1713428) Escherichia coli ED1a 7143469 YP_002397708.1 CDS dicB NC_011745.1 1714132 1714320 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 3041373; Product type h : extrachromosomal origin; Cell division inhibition protein dicB from bacteriophage origin 1714132..1714320 Escherichia coli ED1a 7143470 YP_002397709.1 CDS ECED1_1744 NC_011745.1 1714598 1716955 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2199308; Product type h : extrachromosomal origin; Exodeoxyribonuclease VIII from bacteriophage origin 1714598..1716955 Escherichia coli ED1a 7143115 YP_002397710.1 CDS ECED1_1745 NC_011745.1 1716955 1717278 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative excisionase 1716955..1717278 Escherichia coli ED1a 7143471 YP_002397711.1 CDS intQ NC_011745.1 1717298 1718593 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative defective integrase; Qin prophage 1717298..1718593 Escherichia coli ED1a 7143472 YP_002397712.1 CDS ynfP NC_011745.1 1718613 1718723 R Evidence 6 : Doubtful CDS; hypothetical protein complement(1718613..1718723) Escherichia coli ED1a 7142443 YP_002397713.1 CDS rspB NC_011745.1 1718781 1719800 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7545940; Product type pe : putative enzyme; putative dehydrogenase complement(1718781..1719800) Escherichia coli ED1a 7141017 YP_002397714.1 CDS rspA NC_011745.1 1719812 1721026 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 93341455, 94310441; Product type pe : putative enzyme; putative enolase/dehydratase complement(1719812..1721026) Escherichia coli ED1a 7140118 YP_002397715.1 CDS ynfA NC_011745.1 1721233 1721559 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1721233..1721559) Escherichia coli ED1a 7140116 YP_002397716.1 CDS ynfB NC_011745.1 1721694 1722035 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1721694..1722035 Escherichia coli ED1a 7141004 YP_002397717.1 CDS speG NC_011745.1 1722070 1722630 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94357898; Product type e : enzyme; spermidine N1-acetyltransferase 1722070..1722630 Escherichia coli ED1a 7141005 YP_002397718.1 CDS ynfC NC_011745.1 1722633 1723343 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1722633..1723343) Escherichia coli ED1a 7143829 YP_002397719.1 CDS ynfD NC_011745.1 1723451 1723756 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9868784; hypothetical protein 1723451..1723756 Escherichia coli ED1a 7141006 YP_002397720.1 CDS ynfF NC_011745.1 1726441 1728864 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14522592; Product type e : enzyme; oxidoreductase subunit 1726441..1728864 Escherichia coli ED1a 7141009 YP_002397721.1 CDS ynfG NC_011745.1 1728875 1729492 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14522592; Product type c : carrier; oxidoreductase, Fe-S subunit 1728875..1729492 Escherichia coli ED1a 7141010 YP_002397722.1 CDS ynfH NC_011745.1 1729494 1730348 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14522592; Product type m : membrane component; oxidoreductase, membrane subunit 1729494..1730348 Escherichia coli ED1a 7141011 YP_002397723.1 CDS dmsD NC_011745.1 1730391 1731005 D binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane; twin-argninine leader-binding protein DmsD 1730391..1731005 Escherichia coli ED1a 7141012 YP_002397724.1 CDS clcB NC_011745.1 1731200 1732456 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12384697; Product type pt : putative transporter; putative voltage-gated ClC-type chloride channel ClcB 1731200..1732456 Escherichia coli ED1a 7140501 YP_002397725.1 CDS ynfK NC_011745.1 1732409 1733104 R DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; putative dithiobiotin synthetase complement(1732409..1733104) Escherichia coli ED1a 7139369 YP_002397726.1 CDS dgsA NC_011745.1 1733229 1734449 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10318813, 20490366, 6989798, 99340206, 99395104, 99398866, 7766024; Product type r : regulator; DNA-binding transcriptional repressor complement(1733229..1734449) Escherichia coli ED1a 7141013 YP_002397727.1 CDS ynfL NC_011745.1 1734584 1735477 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(1734584..1735477) Escherichia coli ED1a 7143108 YP_002397728.1 CDS ynfM NC_011745.1 1735584 1736837 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter 1735584..1736837 Escherichia coli ED1a 7141014 YP_002397729.1 CDS asr NC_011745.1 1737262 1737570 D required for growth and survival under moderately acid conditions; acid shock protein 1737262..1737570 Escherichia coli ED1a 7141015 YP_002397730.1 CDS ydgD NC_011745.1 1737846 1738667 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative exported metallopeptidase 1737846..1738667 Escherichia coli ED1a 7142652 YP_002397731.1 CDS mdtI NC_011745.1 1738706 1739035 R with MdtJ is involved in resistance to deoxycholate, nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtI complement(1738706..1739035) Escherichia coli ED1a 7139275 YP_002397732.1 CDS mdtJ NC_011745.1 1739022 1739387 R with MdtI is involved in resistance to deoxycholate , nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtJ complement(1739022..1739387) Escherichia coli ED1a 7142235 YP_002397733.1 CDS ECED1_1771 NC_011745.1 1740262 1740444 R Evidence 6 : Doubtful CDS; hypothetical protein complement(1740262..1740444) Escherichia coli ED1a 7139276 YP_002397734.1 CDS ECED1_1772 NC_011745.1 1740701 1740982 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1740701..1740982) Escherichia coli ED1a 7143473 YP_002397735.1 CDS ECED1_1773 NC_011745.1 1740996 1742657 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage terminase large subunit complement(1740996..1742657) Escherichia coli ED1a 7143474 YP_002397736.1 CDS ECED1_1774 NC_011745.1 1742641 1742997 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage terminase, small subunit complement(1742641..1742997) Escherichia coli ED1a 7143475 YP_002397737.1 CDS ECED1_1775 NC_011745.1 1743289 1743726 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; putative endonuclease complement(1743289..1743726) Escherichia coli ED1a 7143476 YP_002397738.1 CDS ECED1_1777 NC_011745.1 1743726 1744022 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(1743726..1744022) Escherichia coli ED1a 7143477 YP_002397739.1 CDS ECED1_1778 NC_011745.1 1744354 1745565 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative head portal protein complement(1744354..1745565) Escherichia coli ED1a 7143478 YP_002397740.1 CDS ECED1_1779 NC_011745.1 1745567 1746139 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative head maturation protease of prophage complement(1745567..1746139) Escherichia coli ED1a 7143479 YP_002397741.1 CDS ECED1_1780 NC_011745.1 1746179 1747384 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative capsid protein of prophage ( major head protein) complement(1746179..1747384) Escherichia coli ED1a 7143436 YP_002397742.1 CDS ECED1_1781 NC_011745.1 1747637 1747939 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(1747637..1747939) Escherichia coli ED1a 7143437 YP_002397743.1 CDS ECED1_1783 NC_011745.1 1748003 1748371 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8885267; Product type h : extrachromosomal origin; putative transcriptional activator (PerC family) from phage origin complement(1748003..1748371) Escherichia coli ED1a 7143438 YP_002397744.1 CDS ECED1_1784 NC_011745.1 1748262 1748672 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative single stranded DNA-binding protein of prophage complement(1748262..1748672) Escherichia coli ED1a 7140871 YP_002397745.1 CDS ECED1_1785 NC_011745.1 1748669 1748947 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(1748669..1748947) Escherichia coli ED1a 7140872 YP_002397746.1 CDS ECED1_1786 NC_011745.1 1749234 1750982 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; nucleic acid independent nucleoside triphosphatase; phage DNA primase complement(1749234..1750982) Escherichia coli ED1a 7140873 YP_002397747.1 CDS ECED1_1787 NC_011745.1 1750979 1751278 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(1750979..1751278) Escherichia coli ED1a 7140874 YP_002397748.1 CDS ECED1_1788 NC_011745.1 1751284 1751547 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(1751284..1751547) Escherichia coli ED1a 7140875 YP_002397749.1 CDS ECED1_1789 NC_011745.1 1751516 1751707 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(1751516..1751707) Escherichia coli ED1a 7140876 YP_002397750.1 CDS ECED1_1790 NC_011745.1 1751707 1751892 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(1751707..1751892) Escherichia coli ED1a 7140877 YP_002397751.1 CDS ECED1_1791 NC_011745.1 1751885 1752391 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(1751885..1752391) Escherichia coli ED1a 7140878 YP_002397752.1 CDS ECED1_1793 NC_011745.1 1752593 1753045 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1752593..1753045 Escherichia coli ED1a 7140880 YP_002397753.1 CDS ECED1_1794 NC_011745.1 1753103 1753330 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1753103..1753330 Escherichia coli ED1a 7140881 YP_002397754.1 CDS ECED1_1795 NC_011745.1 1753551 1753724 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1753551..1753724 Escherichia coli ED1a 7140882 YP_002397755.1 CDS ECED1_1796 NC_011745.1 1753767 1753955 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1753767..1753955 Escherichia coli ED1a 7140883 YP_002397756.1 CDS ECED1_1797 NC_011745.1 1754225 1754413 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage regulatory protein complement(1754225..1754413) Escherichia coli ED1a 7140884 YP_002397757.1 CDS int NC_011745.1 1754788 1756017 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; integrase of prophage complement(1754788..1756017) Escherichia coli ED1a 7140885 YP_002397758.1 CDS ECED1_1799 NC_011745.1 1755035 1755238 R Evidence 6 : Doubtful CDS; hypothetical protein complement(1755035..1755238) Escherichia coli ED1a 7141175 YP_002397759.1 CDS ydgG NC_011745.1 1756215 1757099 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14727089; Product type pm : putative membrane component; hypothetical protein 1756215..1757099 Escherichia coli ED1a 7140886 YP_002397760.1 CDS pntB NC_011745.1 1757124 1758512 R catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme; pyridine nucleotide transhydrogenase complement(1757124..1758512) Escherichia coli ED1a 7139277 YP_002397761.1 CDS pntA NC_011745.1 1758523 1760055 R forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm; NAD(P) transhydrogenase subunit alpha complement(1758523..1760055) Escherichia coli ED1a 7139079 YP_002397762.1 CDS ydgH NC_011745.1 1760579 1761523 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1760579..1761523 Escherichia coli ED1a 7139078 YP_002397763.1 CDS ydgI NC_011745.1 1761709 1763091 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1311296; Product type pt : putative transporter; putative arginine/ornithine antiporter transporter 1761709..1763091 Escherichia coli ED1a 7139278 YP_002397764.1 CDS folM NC_011745.1 1763128 1763850 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14617668; Product type e : enzyme; short chain dehydrogenase 1763128..1763850 Escherichia coli ED1a 7139279 YP_002397765.1 CDS ydgC NC_011745.1 1763847 1764182 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1763847..1764182) Escherichia coli ED1a 7142161 YP_002397766.1 CDS rstA NC_011745.1 1764302 1765030 D response regulator in two-component regulatory system with RstB; DNA-binding transcriptional regulator RstA 1764302..1765030 Escherichia coli ED1a 7139274 YP_002397767.1 CDS rstB NC_011745.1 1765034 1766335 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93086426, 1495392, 1925016, 2646639; Product type r : regulator; sensor protein RstB 1765034..1766335 Escherichia coli ED1a 7140121 YP_002397768.1 CDS tus NC_011745.1 1766411 1767340 D binds to DNA replication terminator sequences to prevent passage of replication forks; DNA replication terminus site-binding protein 1766411..1767340 Escherichia coli ED1a 7140122 YP_002397769.1 CDS fumC NC_011745.1 1767337 1768740 R class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase complement(1767337..1768740) Escherichia coli ED1a 7140844 YP_002397770.1 CDS fumA NC_011745.1 1768883 1770529 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88193096, 88268900, 92011457, 3005475, 6328431, 9298646; Product type e : enzyme; fumarate hydratase complement(1768883..1770529) Escherichia coli ED1a 7143133 YP_002397771.1 CDS manA NC_011745.1 1770728 1771903 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82100097, 6397402; Product type e : enzyme; mannose-6-phosphate isomerase 1770728..1771903 Escherichia coli ED1a 7143131 YP_002397772.1 CDS ydgA NC_011745.1 1772004 1773512 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1772004..1773512 Escherichia coli ED1a 7142207 YP_002397773.1 CDS uidC NC_011745.1 1773557 1774822 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15774881; Product type t : transporter; putative outer membrane porin protein complement(1773557..1774822) Escherichia coli ED1a 7139273 YP_002397774.1 CDS uidB NC_011745.1 1774861 1776234 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3534890; Product type t : transporter; glucuronide transporter complement(1774861..1776234) Escherichia coli ED1a 7138884 YP_002397775.1 CDS uidA NC_011745.1 1776231 1778042 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87041472, 88038341, 2103475, 8125312; Product type e : enzyme; beta-D-glucuronidase complement(1776231..1778042) Escherichia coli ED1a 7138883 YP_002397776.1 CDS uidR NC_011745.1 1778430 1779020 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88038341, 2823062, 3934044, 11115104; Product type r : regulator; DNA-binding transcriptional repressor complement(1778430..1779020) Escherichia coli ED1a 7138882 YP_002397777.1 CDS hdhA NC_011745.1 1779249 1780016 R Acts on the hydroxyl group at position 7 of the steroid frame; 7-alpha-hydroxysteroid dehydrogenase complement(1779249..1780016) Escherichia coli ED1a 7138885 YP_002397778.1 CDS malI NC_011745.1 1780128 1781156 R regulates malXY which are involved in maltose-glucose transport; DNA-binding transcriptional repressor MalI complement(1780128..1781156) Escherichia coli ED1a 7139863 YP_002397779.1 CDS malX NC_011745.1 1781331 1782923 D phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS); catalyzes the phosphorylation of maltose and glucose concomitant with their translocation across the cell membrane; component IIB catalyzes the phosphorylation of the sugar molecule; IIC forms the translocation channel and contains the substrate specific binding site; bifunctional PTS system maltose and glucose-specific transporter subunits IICB 1781331..1782923 Escherichia coli ED1a 7142197 YP_002397780.1 CDS malY NC_011745.1 1782933 1784105 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20164451, 7665481, 91310596; Product type e : enzyme; bifunctional beta-cystathionase, PLP-dependent and regulator of maltose regulon 1782933..1784105 Escherichia coli ED1a 7142204 YP_002397781.1 CDS add NC_011745.1 1784209 1785210 D catalyzes the formation of inosine from adenosine; adenosine deaminase 1784209..1785210 Escherichia coli ED1a 7142205 YP_002397782.1 CDS ydgJ NC_011745.1 1785246 1786286 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase complement(1785246..1786286) Escherichia coli ED1a 7143658 YP_002397783.1 CDS blr NC_011745.1 1786454 1786654 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20392465, 10931331; Product type m : membrane component; beta-lactam resistance membrane protein 1786454..1786654 Escherichia coli ED1a 7139280 YP_002397784.1 CDS ydgT NC_011745.1 1786928 1787143 D YdgT; in E. coli, when complexed with H-NS or StpA binds a 26 base-pair DNA sequence of oriC; seems to play a role in optimizing the activity of oriC; non-essential; Hha protein paralog; in an hha mutant background, cnu is overexpressed and can compensate hha-induced phenotypes; oriC-binding nucleoid-associated protein 1786928..1787143 Escherichia coli ED1a 7140460 YP_002397785.1 CDS ydgK NC_011745.1 1787229 1787669 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1787229..1787669 Escherichia coli ED1a 7139283 YP_002397786.1 CDS rsxA NC_011745.1 1787746 1788327 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10411911, 10637328, 12773378; Product type pm : putative membrane component; Na(+)-translocating NADH-quinone reductase subunit E 1787746..1788327 Escherichia coli ED1a 7139281 YP_002397787.1 CDS rsxB NC_011745.1 1788327 1788905 D part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfB 1788327..1788905 Escherichia coli ED1a 7140124 YP_002397788.1 CDS rsxC NC_011745.1 1788898 1791024 D part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfC 1788898..1791024 Escherichia coli ED1a 7140125 YP_002397789.1 CDS rnfD NC_011745.1 1791025 1792083 D RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents; electron transport complex protein RnfD 1791025..1792083 Escherichia coli ED1a 7140126 YP_002397790.1 CDS rsxG NC_011745.1 1792087 1792707 D part of membrane-bound complex hought to be involved in electron transport to nitrogen; electron transport complex protein RnfG 1792087..1792707 Escherichia coli ED1a 7140127 YP_002397791.1 CDS rsxE NC_011745.1 1792711 1793406 D in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase; electron transport complex RsxE subunit 1792711..1793406 Escherichia coli ED1a 7140129 YP_002397792.1 CDS nth NC_011745.1 1793406 1794041 D DNA-(apurinic or apyrimidinic site) lyase; has apurinic or apyrimidinic endonuclease activity and DNA N-glycosylase activity; removed damaged DNA at cytosines, thymines and guanines; endonuclease III 1793406..1794041 Escherichia coli ED1a 7140128 YP_002397793.1 CDS tppB NC_011745.1 1794652 1796154 D mutations in this gene confer resistance to the toxic peptide alafosfalin in Salmonella typhimurium; member of proton-dependent oligopeptide transport (POT) system family; in Escherichia coli this gene is regulated by OmpR although not via osmoregulation; putative tripeptide transporter permease 1794652..1796154 Escherichia coli ED1a 7139936 YP_002397794.1 CDS gst NC_011745.1 1796260 1796865 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95096109, 2185038, 9680481; Product type e : enzyme; glutathionine S-transferase 1796260..1796865 Escherichia coli ED1a 7139282 YP_002397795.1 CDS pdxY NC_011745.1 1796909 1797772 R catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxamine kinase complement(1796909..1797772) Escherichia coli ED1a 7139842 YP_002397796.1 CDS tyrS NC_011745.1 1797831 1799105 R catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase complement(1797831..1799105) Escherichia coli ED1a 7144057 YP_002397797.1 CDS pdxH NC_011745.1 1799234 1799890 R catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase complement(1799234..1799890) Escherichia coli ED1a 7140854 YP_002397798.1 CDS ydhA NC_011745.1 1799949 1800278 R MliC; membrane-bound lysozyme inhibitor of c-type lysozyme; lysozyme inhibitor complement(1799949..1800278) Escherichia coli ED1a 7144054 YP_002397799.1 CDS anmK NC_011745.1 1800376 1801485 R catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling; anhydro-N-acetylmuramic acid kinase complement(1800376..1801485) Escherichia coli ED1a 7139284 YP_002397800.1 CDS slyB NC_011745.1 1801759 1802226 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8544813; Product type lp : lipoprotein; putative outer membrane lipoprotein 1801759..1802226 Escherichia coli ED1a 7142582 YP_002397801.1 CDS slyA NC_011745.1 1802273 1802707 R Transcription regulator that can both activate or repress expression; transcriptional regulator SlyA complement(1802273..1802707) Escherichia coli ED1a 7143806 YP_002397802.1 CDS ydhI NC_011745.1 1802908 1803144 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1802908..1803144 Escherichia coli ED1a 7143805 YP_002397803.1 CDS ydhJ NC_011745.1 1803147 1804004 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12900028; Product type e : enzyme; undecaprenyl pyrophosphate phosphatase 1803147..1804004 Escherichia coli ED1a 7139289 YP_002397804.1 CDS ydhK NC_011745.1 1804004 1806016 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1804004..1806016 Escherichia coli ED1a 7139290 YP_002397805.1 CDS sodC NC_011745.1 1806017 1806538 R SodC; copper and zinc binding; converts superoxide radicals to hydrogen peroxide and water; superoxide dismutase complement(1806017..1806538) Escherichia coli ED1a 7139291 YP_002397806.1 CDS ydhF NC_011745.1 1806619 1807515 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase complement(1806619..1807515) Escherichia coli ED1a 7143816 YP_002397807.1 CDS ydhM NC_011745.1 1807990 1808505 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1807990..1808505 Escherichia coli ED1a 7139288 YP_002397808.1 CDS nemA NC_011745.1 1808542 1809639 D FMN-linked; catalyzes the formation of N-ethylsuccinimide from N-ethylmaleimide; N-ethylmaleimide reductase 1808542..1809639 Escherichia coli ED1a 7139292 YP_002397809.1 CDS gloA NC_011745.1 1809720 1810127 D Ni-dependent; catalyzes the formation of S-lactoylglutathione from methylglyoxal and glutathione; glyoxalase I 1809720..1810127 Escherichia coli ED1a 7140374 YP_002397810.1 CDS rnt NC_011745.1 1810230 1810877 D Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A); ribonuclease T 1810230..1810877 Escherichia coli ED1a 7142964 YP_002397811.1 CDS ydhD NC_011745.1 1811249 1811596 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15833738, 15840565, 11950925, 12730244; Product type e : enzyme; hypothetical protein complement(1811249..1811596) Escherichia coli ED1a 7141443 YP_002397812.1 CDS ydhO NC_011745.1 1811931 1812758 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative exported hydrolase 1811931..1812758 Escherichia coli ED1a 7139287 YP_002397813.1 CDS sodB NC_011745.1 1812886 1813467 D SodB; iron binding; present under aerobic and anaerobic conditions; destroys free radicals; superoxide dismutase 1812886..1813467 Escherichia coli ED1a 7139293 YP_002397814.1 CDS ydhP NC_011745.1 1813613 1814782 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative efflux protein; MFS family complement(1813613..1814782) Escherichia coli ED1a 7143815 YP_002397815.1 CDS purR NC_011745.1 1815336 1816361 D binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers; DNA-binding transcriptional repressor PurR 1815336..1816361 Escherichia coli ED1a 7139294 YP_002397816.1 CDS ydhB NC_011745.1 1816358 1817290 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2404765; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(1816358..1817290) Escherichia coli ED1a 7141224 YP_002397817.1 CDS ydhC NC_011745.1 1817403 1818614 D uncharacterized member of the major facilitator superfamily (MFS); inner membrane transport protein YdhC 1817403..1818614 Escherichia coli ED1a 7139285 YP_002397818.1 CDS cfa NC_011745.1 1818905 1820053 D catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge; cyclopropane fatty acyl phospholipid synthase 1818905..1820053 Escherichia coli ED1a 7139286 YP_002397819.1 CDS ribC NC_011745.1 1820093 1820734 R catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha complement(1820093..1820734) Escherichia coli ED1a 7139328 YP_002397820.1 CDS mdtK NC_011745.1 1820949 1822322 D NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones; multidrug efflux protein 1820949..1822322 Escherichia coli ED1a 7142745 YP_002397821.1 CDS ydhQ NC_011745.1 1822363 1823619 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1822363..1823619) Escherichia coli ED1a 7142237 YP_002397822.1 CDS ydhR NC_011745.1 1824192 1824497 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1824192..1824497 Escherichia coli ED1a 7140786 YP_002397823.1 CDS ydhS NC_011745.1 1824623 1826227 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1824623..1826227 Escherichia coli ED1a 7139296 YP_002397824.1 CDS ydhT NC_011745.1 1826239 1827051 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1826239..1827051) Escherichia coli ED1a 7139297 YP_002397825.1 CDS ydhU NC_011745.1 1827055 1827840 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative cytochrome b subunit of a reductase complement(1827055..1827840) Escherichia coli ED1a 7139298 YP_002397826.1 CDS ydhX NC_011745.1 1827837 1828505 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative 4Fe-4S ferridoxin-type subunit of oxidoreductase complement(1827837..1828505) Escherichia coli ED1a 7139299 YP_002397827.1 CDS ydhW NC_011745.1 1828569 1829216 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1828569..1829216) Escherichia coli ED1a 7139303 YP_002397828.1 CDS ydhY NC_011745.1 1831344 1831970 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; hypothetical protein complement(1831344..1831970) Escherichia coli ED1a 7139301 YP_002397829.1 CDS ydhZ NC_011745.1 1832426 1832635 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1832426..1832635) Escherichia coli ED1a 7139304 YP_002397830.1 CDS pykF NC_011745.1 1833193 1834605 D catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1833193..1834605 Escherichia coli ED1a 7142524 YP_002397831.1 CDS lpp NC_011745.1 1834916 1835152 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 334727, 338599, 322142, 353292, 391404, 4261992, 4575979, 6765942; Product type lp : lipoprotein; murein lipoprotein 1834916..1835152 Escherichia coli ED1a 7141230 YP_002397832.1 CDS ynhG NC_011745.1 1835215 1836219 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1835215..1836219) Escherichia coli ED1a 7141914 YP_002397833.1 CDS sufE NC_011745.1 1836368 1836784 R Acts with SufS to catalyze the formation of L-alanine from L-cysteine; cysteine desufuration protein SufE complement(1836368..1836784) Escherichia coli ED1a 7141018 YP_002397834.1 CDS sufS NC_011745.1 1836797 1838017 R catalyzes the formation of L-alanine and selenide or sulfanylcysteine from selenocysteine or cysteine; bifunctional cysteine desulfurase/selenocysteine lyase complement(1836797..1838017) Escherichia coli ED1a 7141494 YP_002397835.1 CDS sufD NC_011745.1 1838014 1839285 R with SufBC activates cysteine desulfurase SufS; cysteine desulfurase activator complex subunit SufD complement(1838014..1839285) Escherichia coli ED1a 7141496 YP_002397836.1 CDS sufC NC_011745.1 1839260 1840006 R part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE; cysteine desulfurase ATPase complement(1839260..1840006) Escherichia coli ED1a 7141493 YP_002397837.1 CDS sufB NC_011745.1 1840016 1841503 R with SufCD activates cysteine desulfurase SufS; cysteine desulfurase activator complex subunit SufB complement(1840016..1841503) Escherichia coli ED1a 7141492 YP_002397838.1 CDS sufA NC_011745.1 1841512 1841880 R functions as a scaffold on which iron-sulfur clusters ([2Fe-2S]; [4Fe-4S]) are assembled; forms a homodimer; similar to IscA protein; iron-sulfur cluster assembly scaffold protein complement(1841512..1841880) Escherichia coli ED1a 7141491 YP_002397839.1 CDS ydiH NC_011745.1 1842429 1842698 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1842429..1842698) Escherichia coli ED1a 7140751 YP_002397840.1 CDS ydiI NC_011745.1 1842717 1843127 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15808744; Product type pe : putative enzyme; hypothetical protein complement(1842717..1843127) Escherichia coli ED1a 7141628 YP_002397841.1 CDS ydiJ NC_011745.1 1843124 1846180 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11102686; Product type pe : putative enzyme; putative FAD-linked oxidoreductase complement(1843124..1846180) Escherichia coli ED1a 7141629 YP_002397842.1 CDS ydiK NC_011745.1 1846394 1847506 D YdiK; inner membrane protein; ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated; unknown function; putative inner membrane protein 1846394..1847506 Escherichia coli ED1a 7141630 YP_002397843.1 CDS ydiL NC_011745.1 1847935 1848291 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1847935..1848291 Escherichia coli ED1a 7140083 YP_002397844.1 CDS ydiM NC_011745.1 1848391 1849605 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter 1848391..1849605 Escherichia coli ED1a 7141632 YP_002397845.1 CDS ydiN NC_011745.1 1849832 1851097 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 1849832..1851097 Escherichia coli ED1a 7141633 YP_002397846.1 CDS ydiB NC_011745.1 1851109 1851975 D YdiB; quinate/shikimate dehydrogenase from Escherichia coli uses both NAD and NAD(P) to convert quinate and shikimate to 3-dehydroquinate and 3-dehydroshikimate; quinate/shikimate dehydrogenase 1851109..1851975 Escherichia coli ED1a 7141634 YP_002397847.1 CDS aroD NC_011745.1 1852006 1852764 D catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase 1852006..1852764 Escherichia coli ED1a 7141624 YP_002397848.1 CDS ydiF NC_011745.1 1852909 1854357 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16253988; Product type e : enzyme; short chain acyl-CoA transferase subunit alpha/beta 1852909..1854357 Escherichia coli ED1a 7142626 YP_002397849.1 CDS insB NC_011745.1 1854292 1854795 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' complement(1854292..1854795) Escherichia coli ED1a 7141627 YP_002397850.1 CDS insA NC_011745.1 1854714 1854989 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA complement(1854714..1854989) Escherichia coli ED1a 7141142 YP_002397851.1 CDS ydiO NC_011745.1 1855294 1856445 D may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain; putative acyl-CoA dehydrogenase 1855294..1856445 Escherichia coli ED1a 7141120 YP_002397852.1 CDS ydiP NC_011745.1 1856488 1857399 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(1856488..1857399) Escherichia coli ED1a 7141635 YP_002397853.1 CDS ECED1_1898 NC_011745.1 1857502 1857678 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1857502..1857678) Escherichia coli ED1a 7141636 YP_002397854.1 CDS ydiQ NC_011745.1 1857715 1858479 D YdiO, YdiQ, YdiR, YdiS, and YdiT may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain; putative electron transfer flavoprotein YdiQ 1857715..1858479 Escherichia coli ED1a 7140887 YP_002397855.1 CDS ydiR NC_011745.1 1858499 1859437 D May play a role in a redox process; electron transfer flavoprotein subunit YdiR 1858499..1859437 Escherichia coli ED1a 7141637 YP_002397856.1 CDS ydiS NC_011745.1 1859492 1860781 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; hypothetical protein 1859492..1860781 Escherichia coli ED1a 7141638 YP_002397857.1 CDS ydiT NC_011745.1 1860778 1861071 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative 4Fe-4S ferredoxin-type oxidoreductase subunit 1860778..1861071 Escherichia coli ED1a 7141639 YP_002397858.1 CDS ydiD NC_011745.1 1861074 1862774 D acts in anaerobic beta-oxidation of fatty acids; possible ligase/synthase involved in anaerobic growth on fatty acids; short chain acyl-CoA synthetase 1861074..1862774 Escherichia coli ED1a 7141640 YP_002397859.1 CDS pps NC_011745.1 1862831 1865209 R catalyzes the formation of phosphoenolpyruvate from pyruvate; phosphoenolpyruvate synthase complement(1862831..1865209) Escherichia coli ED1a 7141625 YP_002397860.1 CDS ydiA NC_011745.1 1865542 1866375 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1865542..1866375 Escherichia coli ED1a 7139109 YP_002397861.1 CDS aroH NC_011745.1 1866532 1867578 D tryptophan sensitive; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate; phospho-2-dehydro-3-deoxyheptonate aldolase 1866532..1867578 Escherichia coli ED1a 7141623 YP_002397862.1 CDS ydiE NC_011745.1 1867710 1867901 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 15039350; hypothetical protein 1867710..1867901 Escherichia coli ED1a 7142630 YP_002397863.1 CDS ydiU NC_011745.1 1867905 1869341 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1867905..1869341) Escherichia coli ED1a 7141626 YP_002397864.1 CDS ydiV NC_011745.1 1869404 1870117 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1869404..1870117) Escherichia coli ED1a 7141641 YP_002397865.1 CDS nlpC NC_011745.1 1870364 1870828 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12620121; Product type lp : lipoprotein; putative peptidase lipoprotein complement(1870364..1870828) Escherichia coli ED1a 7141642 YP_002397866.1 CDS btuD NC_011745.1 1870906 1871655 R ATP-binding protein that acts with the transmembrane protein BtuC and the solute binding protein BtuF to transport vitamin B12 into the cell; vitamin B12-transporter ATPase complement(1870906..1871655) Escherichia coli ED1a 7140399 YP_002397867.1 CDS btuE NC_011745.1 1871655 1872206 R similar to glutathione peroxidase; member of the btuCED operon which is required for vitamin B12 transport across the inner membrane; putative glutathione peroxidase complement(1871655..1872206) Escherichia coli ED1a 7140466 YP_002397868.1 CDS btuC NC_011745.1 1872268 1873248 R with BtuD and BtuF transports vitamin B12 into the cell; vtamin B12-transporter permease complement(1872268..1873248) Escherichia coli ED1a 7140467 YP_002397869.1 CDS ihfA NC_011745.1 1873349 1873648 R This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit alpha complement(1873349..1873648) Escherichia coli ED1a 7140465 YP_002397870.1 CDS pheT NC_011745.1 1873653 1876040 R catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta complement(1873653..1876040) Escherichia coli ED1a 7140232 YP_002397871.1 CDS pheS NC_011745.1 1876055 1877038 R catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha complement(1876055..1877038) Escherichia coli ED1a 7144086 YP_002397873.1 CDS rplT NC_011745.1 1877489 1877845 R binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 complement(1877489..1877845) Escherichia coli ED1a 7144083 YP_002397874.1 CDS rpmI NC_011745.1 1877898 1878095 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93085722, 10094780, 3298224, 3542048, 6325158; Product type s : structure; 50S ribosomal protein L35 complement(1877898..1878095) Escherichia coli ED1a 7141469 YP_002397875.1 CDS thrS NC_011745.1 1878738 1880666 R catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; threonyl-tRNA synthetase complement(1878738..1880666) Escherichia coli ED1a 7141111 YP_002397876.1 CDS ydiY NC_011745.1 1882551 1883309 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1882551..1883309) Escherichia coli ED1a 7140891 YP_002397877.1 CDS pfkB NC_011745.1 1883595 1884524 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 78194149, 88292964, 6235149, 6310120; Product type e : enzyme; 6-phosphofructokinase 2 1883595..1884524 Escherichia coli ED1a 7141643 YP_002397878.1 CDS ydiZ NC_011745.1 1884625 1884915 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1884625..1884915 Escherichia coli ED1a 7144068 YP_002397879.1 CDS yniA NC_011745.1 1885021 1885881 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphotransferase/kinase 1885021..1885881 Escherichia coli ED1a 7141644 YP_002397880.1 CDS yniB NC_011745.1 1885922 1886458 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1885922..1886458) Escherichia coli ED1a 7141019 YP_002397881.1 CDS yniC NC_011745.1 1886605 1887273 D YniC; catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate, mannose 6-phosphate and p-nitrophenyl phosphate; 2-deoxyglucose-6-phosphatase 1886605..1887273 Escherichia coli ED1a 7141020 YP_002397882.1 CDS ydjM NC_011745.1 1887436 1888026 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10760155; Product type pm : putative membrane component; hypothetical protein 1887436..1888026 Escherichia coli ED1a 7139918 YP_002397883.1 CDS ydjN NC_011745.1 1888159 1889550 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative cation-acid symporter 1888159..1889550 Escherichia coli ED1a 7141655 YP_002397884.1 CDS cedA NC_011745.1 1889597 1889860 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9427399; Product type cp : cell process; cell division modulator complement(1889597..1889860) Escherichia coli ED1a 7141656 YP_002397885.1 CDS katE NC_011745.1 1890043 1892304 D Catalase HPII; monofunctional catalase that decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide; hydroperoxidase II 1890043..1892304 Escherichia coli ED1a 7139327 YP_002397886.1 CDS chbG NC_011745.1 1892350 1893108 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 20042356, 1987146, 2179047, 8121401, 9405618; hypothetical protein complement(1892350..1893108) Escherichia coli ED1a 7142484 YP_002397887.1 CDS chbF NC_011745.1 1893121 1894473 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20042356, 90185127, 9405618; Product type e : enzyme; cryptic phospho-beta-glucosidase, NAD(P)-binding complement(1893121..1894473) Escherichia coli ED1a 7139336 YP_002397888.1 CDS chbR NC_011745.1 1894577 1895419 R represses the celABCDF-ydjC operon involved in carbon uptake; DNA-binding transcriptional regulator ChbR complement(1894577..1895419) Escherichia coli ED1a 7139335 YP_002397889.1 CDS chbA NC_011745.1 1895427 1895777 R catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIA complement(1895427..1895777) Escherichia coli ED1a 7139337 YP_002397890.1 CDS chbC NC_011745.1 1895828 1897186 R catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC complement(1895828..1897186) Escherichia coli ED1a 7139332 YP_002397891.1 CDS chbB NC_011745.1 1897271 1897591 R catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIB complement(1897271..1897591) Escherichia coli ED1a 7139334 YP_002397892.1 CDS osmE NC_011745.1 1897890 1898228 R osmotically-inducible lipoprotein E; activator of ntr-like gene protein; DNA-binding transcriptional activator OsmE complement(1897890..1898228) Escherichia coli ED1a 7139333 YP_002397893.1 CDS nadE NC_011745.1 1898430 1899257 D catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase 1898430..1899257 Escherichia coli ED1a 7139989 YP_002397894.1 CDS ydjQ NC_011745.1 1899487 1900374 D 3' incision activity; acts with UvrC; nucleotide excision repair endonuclease 1899487..1900374 Escherichia coli ED1a 7140334 YP_002397895.1 CDS ydjR NC_011745.1 1900334 1900909 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 21862596; hypothetical protein complement(1900334..1900909) Escherichia coli ED1a 7141657 YP_002397896.1 CDS spy NC_011745.1 1901112 1901597 R periplasmic protein induced by stress response via Cpx and BaeSR system; similar to CpxP; periplasmic protein complement(1901112..1901597) Escherichia coli ED1a 7141658 YP_002397897.1 CDS astE NC_011745.1 1901927 1902895 R catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism; succinylglutamate desuccinylase complement(1901927..1902895) Escherichia coli ED1a 7143835 YP_002397898.1 CDS astB NC_011745.1 1902888 1904231 R catalyzes the hydrolysis of 2-N-succinylarginine into 2-N-succinylornithine, ammonia and carbon dioxide in arginine degradation; succinylarginine dihydrolase complement(1902888..1904231) Escherichia coli ED1a 7142658 YP_002397899.1 CDS astD NC_011745.1 1904228 1905706 R a high throughput screen identified this enzyme as an aldehyde dehydrogenase with broad substrate specificity; converts succinylglutamate semialdehyde and NAD to succinylglutamate and NADH; succinylglutamic semialdehyde dehydrogenase complement(1904228..1905706) Escherichia coli ED1a 7142655 YP_002397900.1 CDS astA NC_011745.1 1905703 1906737 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14675764, 98361920; Product type e : enzyme; arginine succinyltransferase complement(1905703..1906737) Escherichia coli ED1a 7142657 YP_002397901.1 CDS astC NC_011745.1 1906734 1907954 R catalyzes the transamination of 2-N-succinylornithine and alpha-ketoglutarate into 2-N-succinylglutamate semialdehyde and glutamate; also functions as the catabolic acetylornithine aminotransferase catalyzing the formation of 2-N-acetylglutamate semialdehyde and glutamate from 2-N-acetylornithine and alpha-ketoglutarate; bifunctional succinylornithine transaminase/acetylornithine transaminase complement(1906734..1907954) Escherichia coli ED1a 7142654 YP_002397902.1 CDS xthA NC_011745.1 1908400 1909206 D removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction; exonuclease III 1908400..1909206 Escherichia coli ED1a 7142656 YP_002397903.1 CDS ydjX NC_011745.1 1909373 1910083 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1909373..1910083 Escherichia coli ED1a 7139211 YP_002397904.1 CDS ydjY NC_011745.1 1910088 1910765 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1910088..1910765 Escherichia coli ED1a 7141659 YP_002397905.1 CDS ydjZ NC_011745.1 1910779 1911486 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1910779..1911486 Escherichia coli ED1a 7141660 YP_002397906.1 CDS ynjA NC_011745.1 1911486 1912034 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1911486..1912034 Escherichia coli ED1a 7141661 YP_002397907.1 CDS ynjB NC_011745.1 1912044 1913210 D Evidence 4 : Homologs of previously reported genes of unknown function; putative ABC transporter solute-binding protein 1912044..1913210 Escherichia coli ED1a 7140243 YP_002397908.1 CDS ynjC NC_011745.1 1913228 1914718 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; fused putative transporter subunits of ABC superfamily: membrane components 1913228..1914718 Escherichia coli ED1a 7140244 YP_002397909.1 CDS ynjD NC_011745.1 1914718 1915371 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sulfate/thiosulfate ABC transporter ATP-binding protein transporter 1914718..1915371 Escherichia coli ED1a 7140245 YP_002397910.1 CDS ynjE NC_011745.1 1915438 1916745 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative exported thiosulfate sulfur transferase / thiosulfate binding protein 1915438..1916745 Escherichia coli ED1a 7140246 YP_002397911.1 CDS ynjF NC_011745.1 1916754 1917374 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type m : membrane component; putative phosphatidyl transferase, inner membrane protein complement(1916754..1917374) Escherichia coli ED1a 7140247 YP_002397912.1 CDS nudG NC_011745.1 1917461 1917868 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21101911; Product type e : enzyme; pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase 1917461..1917868 Escherichia coli ED1a 7140248 YP_002397913.1 CDS gdhA NC_011745.1 1918342 1919685 D converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 1918342..1919685 Escherichia coli ED1a 7139942 YP_002397914.1 CDS topB NC_011745.1 1919762 1921774 R decatenates replicating daughter chromosomes; DNA topoisomerase III complement(1919762..1921774) Escherichia coli ED1a 7143173 YP_002397915.1 CDS selD NC_011745.1 1921722 1922765 R catalyzes the formation of selenophosphate from selenide and ATP; selenophosphate synthetase complement(1921722..1922765) Escherichia coli ED1a 7140791 YP_002397916.1 CDS ECED1_1965 NC_011745.1 1922707 1922856 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1922707..1922856) Escherichia coli ED1a 7141395 YP_002397917.1 CDS ydjA NC_011745.1 1922882 1923433 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein complement(1922882..1923433) Escherichia coli ED1a 7140892 YP_002397918.1 CDS ECED1_1967 NC_011745.1 1923487 1923651 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1923487..1923651 Escherichia coli ED1a 7141645 YP_002397919.1 CDS sppA NC_011745.1 1923594 1925450 D SppA; catalyzes the degradation of cleaved signal peptides; essential to maintain secretion of mature proteins across the membrane; protease 4 1923594..1925450 Escherichia coli ED1a 7140893 YP_002397920.1 CDS ansA NC_011745.1 1925617 1926633 D converts asparagine to aspartate and ammonia; cytoplasmic asparaginase I 1925617..1926633 Escherichia coli ED1a 7143832 YP_002397921.1 CDS pncA NC_011745.1 1926644 1927285 D catalyzes the formation of nicotinate from nicotinamide in NAD biosynthesis and the formation of pyrazinoate from pyrazinamide; nicotinamidase/pyrazinamidase 1926644..1927285 Escherichia coli ED1a 7142583 YP_002397922.1 CDS ydjE NC_011745.1 1927378 1928736 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter complement(1927378..1928736) Escherichia coli ED1a 7139075 YP_002397923.1 CDS ECED1_1972 NC_011745.1 1928709 1928852 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1928709..1928852 Escherichia coli ED1a 7141646 YP_002397924.1 CDS ydjF NC_011745.1 1928854 1929612 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(1928854..1929612) Escherichia coli ED1a 7140894 YP_002397925.1 CDS ydjH NC_011745.1 1930739 1931686 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sugar kinase complement(1930739..1931686) Escherichia coli ED1a 7141649 YP_002397926.1 CDS ydjI NC_011745.1 1931691 1932527 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative aldolase complement(1931691..1932527) Escherichia coli ED1a 7141650 YP_002397927.1 CDS ydjJ NC_011745.1 1932548 1933591 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12897001; Product type pe : putative enzyme; putative iditol dehydrogenase complement(1932548..1933591) Escherichia coli ED1a 7141651 YP_002397928.1 CDS ydjK NC_011745.1 1933608 1934987 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter complement(1933608..1934987) Escherichia coli ED1a 7141652 YP_002397929.1 CDS ydjL NC_011745.1 1935014 1936090 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase, Zn-dependent and NAD(P)-binding complement(1935014..1936090) Escherichia coli ED1a 7141653 YP_002397930.1 CDS yeaC NC_011745.1 1936460 1936732 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1936460..1936732) Escherichia coli ED1a 7141654 YP_002397931.1 CDS msrB NC_011745.1 1936774 1937187 R this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress; methionine sulfoxide reductase B complement(1936774..1937187) Escherichia coli ED1a 7141663 YP_002397932.1 CDS gapA NC_011745.1 1937529 1938524 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 775311, 94131963, 98361923, 1862091, 2124629, 2990926, 7896119, 8636984, 9298646; Product type e : enzyme; glyceraldehyde-3-phosphate dehydrogenase A 1937529..1938524 Escherichia coli ED1a 7139035 YP_002397933.1 CDS yeaD NC_011745.1 1938608 1939492 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1938608..1939492 Escherichia coli ED1a 7143157 YP_002397934.1 CDS yeaE NC_011745.1 1939543 1940397 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase complement(1939543..1940397) Escherichia coli ED1a 7141664 YP_002397935.1 CDS mipA NC_011745.1 1940487 1941233 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10037771, 20267815; Product type f : factor; scaffolding protein for murein synthesizing machinery complement(1940487..1941233) Escherichia coli ED1a 7141665 YP_002397936.1 CDS yeaG NC_011745.1 1941669 1943603 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1941669..1943603 Escherichia coli ED1a 7138988 YP_002397937.1 CDS yeaH NC_011745.1 1943716 1944999 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1943716..1944999 Escherichia coli ED1a 7141666 YP_002397938.1 CDS yeaI NC_011745.1 1945146 1946621 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative diguanylate cyclase 1945146..1946621 Escherichia coli ED1a 7141667 YP_002397939.1 CDS yeaK NC_011745.1 1948335 1948838 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1948335..1948838 Escherichia coli ED1a 7141670 YP_002397940.1 CDS ECED1_1994 NC_011745.1 1948839 1948991 R Evidence 6 : Doubtful CDS; hypothetical protein complement(1948839..1948991) Escherichia coli ED1a 7141671 YP_002397941.1 CDS yeaL NC_011745.1 1949113 1949559 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1949113..1949559 Escherichia coli ED1a 7140895 YP_002397942.1 CDS yeaM NC_011745.1 1949516 1950337 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(1949516..1950337) Escherichia coli ED1a 7141672 YP_002397943.1 CDS yeaN NC_011745.1 1950434 1951615 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter 1950434..1951615 Escherichia coli ED1a 7141673 YP_002397944.1 CDS yeaO NC_011745.1 1951670 1952017 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1951670..1952017 Escherichia coli ED1a 7141674 YP_002397945.1 CDS yoaF NC_011745.1 1952039 1952293 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1952039..1952293) Escherichia coli ED1a 7141675 YP_002397946.1 CDS yeaP NC_011745.1 1952476 1953501 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative diguanylate cyclase 1952476..1953501 Escherichia coli ED1a 7140253 YP_002397947.1 CDS yeaQ NC_011745.1 1953768 1954016 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1953768..1954016) Escherichia coli ED1a 7141676 YP_002397948.1 CDS yoaG NC_011745.1 1954164 1954346 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1954164..1954346) Escherichia coli ED1a 7141677 YP_002397949.1 CDS yeaR NC_011745.1 1954350 1954709 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1954350..1954709) Escherichia coli ED1a 7140254 YP_002397950.1 CDS yeaS NC_011745.1 1954882 1955520 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; leucine export protein LeuE complement(1954882..1955520) Escherichia coli ED1a 7141678 YP_002397951.1 CDS ECED1_2005 NC_011745.1 1955647 1955979 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative LuxR family transcription regulator complement(1955647..1955979) Escherichia coli ED1a 7141679 YP_002397952.1 CDS rnd NC_011745.1 1956063 1957190 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88289400, 89053950, 93015723, 8107670; Product type e : enzyme; ribonuclease D complement(1956063..1957190) Escherichia coli ED1a 7141680 YP_002397953.1 CDS fadD NC_011745.1 1957260 1958945 R Activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase complement(1957260..1958945) Escherichia coli ED1a 7141434 YP_002397954.1 CDS yeaY NC_011745.1 1959150 1959731 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16079137; Product type lp : lipoprotein; putative outer membrane-associated lipoprotein complement(1959150..1959731) Escherichia coli ED1a 7144126 YP_002397955.1 CDS yeaZ NC_011745.1 1959771 1960466 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative peptidase complement(1959771..1960466) Escherichia coli ED1a 7141681 YP_002397956.1 CDS yoaA NC_011745.1 1960524 1962434 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ATP-dependent helicase complement(1960524..1962434) Escherichia coli ED1a 7141682 YP_002397957.1 CDS yoaB NC_011745.1 1962566 1962910 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1962566..1962910 Escherichia coli ED1a 7140249 YP_002397958.1 CDS yoaC NC_011745.1 1963272 1963631 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1963272..1963631 Escherichia coli ED1a 7140250 YP_002397959.1 CDS yoaH NC_011745.1 1963751 1963930 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1963751..1963930) Escherichia coli ED1a 7140251 YP_002397960.1 CDS pabB NC_011745.1 1964004 1965365 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88025006, 91067712, 91302313, 96011382, 6330050, 7896119; Product type e : enzyme; aminodeoxychorismate synthase subunit I 1964004..1965365 Escherichia coli ED1a 7140255 YP_002397961.1 CDS yeaB NC_011745.1 1965369 1965947 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7567469; Product type pe : putative enzyme; hypothetical protein 1965369..1965947 Escherichia coli ED1a 7144036 YP_002397962.1 CDS sdaA NC_011745.1 1966131 1967495 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15155761, 89359152, 91056090, 93170282; Product type e : enzyme; L-serine deaminase I 1966131..1967495 Escherichia coli ED1a 7141662 YP_002397963.1 CDS adrB NC_011745.1 1967626 1969224 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16513732; Product type pe : putative enzyme; putative cyclic di-GMP phosphodiesterase 1967626..1969224 Escherichia coli ED1a 7141377 YP_002397964.1 CDS yoaE NC_011745.1 1969228 1970784 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein complement(1969228..1970784) Escherichia coli ED1a 7143666 YP_002397965.1 CDS manX NC_011745.1 1971248 1972219 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87165962, 90036983, 8131846, 8676384, 9074635, 9298646; Product type t : transporter; fused mannose-specific PTS enzymes: IIA component ; IIB component 1971248..1972219 Escherichia coli ED1a 7140252 YP_002397966.1 CDS manY NC_011745.1 1972282 1973082 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10473571, 87165962, 90036983, 94086520, 97128775, 7811395, 8774730; Product type t : transporter; PTS system mannose-specific protein subunit IIC 1972282..1973082 Escherichia coli ED1a 7142208 YP_002397967.1 CDS manZ NC_011745.1 1973086 1973946 D hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel; PTS system mannose-specific transporter subunit IID 1973086..1973946 Escherichia coli ED1a 7142209 YP_002397968.1 CDS yobD NC_011745.1 1974001 1974459 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1974001..1974459 Escherichia coli ED1a 7142210 YP_002397969.1 CDS yebN NC_011745.1 1974888 1975454 D membrane protein YebN; hypothetical protein 1974888..1975454 Escherichia coli ED1a 7140753 YP_002397970.1 CDS rrmA NC_011745.1 1975451 1976260 R methylates the guanosine in position 745 of 23S rRNA; required for translation and cell growth; 23S rRNA methyltransferase A complement(1975451..1976260) Escherichia coli ED1a 7141690 YP_002397971.1 CDS cspC NC_011745.1 1976426 1976635 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20345064, 21101802, 94293754, 12071744, 7984109, 8022261, 9298646, 9868784, 9921691; Product type f : factor; cold shock-like protein CspC complement(1976426..1976635) Escherichia coli ED1a 7140106 YP_002397972.1 CDS yobF NC_011745.1 1976648 1976791 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1976648..1976791) Escherichia coli ED1a 7142070 YP_002397973.1 CDS yebO NC_011745.1 1977461 1977748 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1977461..1977748) Escherichia coli ED1a 7140259 YP_002397974.1 CDS yobG NC_011745.1 1977823 1977966 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1977823..1977966) Escherichia coli ED1a 7141691 YP_002397975.1 CDS yobH NC_011745.1 1978125 1978364 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1978125..1978364 Escherichia coli ED1a 7140260 YP_002397976.1 CDS kdgR NC_011745.1 1978508 1979299 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15659677, 4359651; Product type r : regulator; DNA-binding transcriptional repressor KdgR complement(1978508..1979299) Escherichia coli ED1a 7140261 YP_002397977.1 CDS yebQ NC_011745.1 1979476 1980849 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter 1979476..1980849 Escherichia coli ED1a 7142491 YP_002397978.1 CDS htpX NC_011745.1 1980895 1981776 R putative metalloprotease; heat shock protein HtpX complement(1980895..1981776) Escherichia coli ED1a 7141692 YP_002397979.1 CDS prc NC_011745.1 1981968 1984016 R Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3; carboxy-terminal protease complement(1981968..1984016) Escherichia coli ED1a 7140173 YP_002397980.1 CDS proQ NC_011745.1 1984036 1984734 R affects solute and DNA transport through an unknown mechanism; putative solute/DNA competence effector complement(1984036..1984734) Escherichia coli ED1a 7139114 YP_002397981.1 CDS yebR NC_011745.1 1984831 1985382 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1984831..1985382) Escherichia coli ED1a 7139131 YP_002397982.1 CDS yebS NC_011745.1 1985458 1986741 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1985458..1986741 Escherichia coli ED1a 7141693 YP_002397983.1 CDS yebT NC_011745.1 1986710 1989343 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1986710..1989343 Escherichia coli ED1a 7141694 YP_002397984.1 CDS yebU NC_011745.1 1989423 1990862 D in Escherichia coli this enzyme specifically methylates C1407 of the 16S rRNA; rRNA (cytosine-C(5)-)-methyltransferase RsmF 1989423..1990862 Escherichia coli ED1a 7141695 YP_002397985.1 CDS yebV NC_011745.1 1990980 1991216 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1990980..1991216 Escherichia coli ED1a 7141696 YP_002397986.1 CDS yebW NC_011745.1 1991237 1991512 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1991237..1991512 Escherichia coli ED1a 7141697 YP_002397987.1 CDS pphA NC_011745.1 1991513 1992169 R Plays a key role in signaling protein misfolding via the cpxR/cpxA transducing system; modulates the phosphorylated status of many phosphoproteins; serine/threonine protein phosphatase 1 complement(1991513..1992169) Escherichia coli ED1a 7141698 YP_002397988.1 CDS ECED1_2043 NC_011745.1 1992394 1992546 R Evidence 6 : Doubtful CDS; hypothetical protein complement(1992394..1992546) Escherichia coli ED1a 7140154 YP_002397989.1 CDS yebY NC_011745.1 1992564 1992905 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1992564..1992905) Escherichia coli ED1a 7140897 YP_002397990.1 CDS yebZ NC_011745.1 1992918 1993790 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1992918..1993790) Escherichia coli ED1a 7141699 YP_002397991.1 CDS yobA NC_011745.1 1993794 1994168 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1993794..1994168) Escherichia coli ED1a 7141700 YP_002397992.1 CDS holE NC_011745.1 1994307 1994537 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15090519, 92147649, 92156151, 94131961, 1575709, 8341603, 8505306; Product type e : enzyme; DNA polymerase III subunit theta 1994307..1994537 Escherichia coli ED1a 7140256 YP_002397993.1 CDS yobB NC_011745.1 1994639 1995295 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1994639..1995295 Escherichia coli ED1a 7139914 YP_002397994.1 CDS exoX NC_011745.1 1995318 1995980 D 3'-5' exonuclease activity on single or double-strand DNA; exodeoxyribonuclease X 1995318..1995980 Escherichia coli ED1a 7140257 YP_002397995.1 CDS ptrB NC_011745.1 1995977 1998037 R PtrB; oligopeptidase that cleaves peptide bonds following arginine and lysine residues; protease 2 complement(1995977..1998037) Escherichia coli ED1a 7139833 YP_002397996.1 CDS yebE NC_011745.1 1998246 1998905 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1998246..1998905) Escherichia coli ED1a 7141204 YP_002397997.1 CDS yebF NC_011745.1 1999232 1999600 R secreted protein; unknown function; hypothetical protein complement(1999232..1999600) Escherichia coli ED1a 7141686 YP_002397998.1 CDS yebG NC_011745.1 1999655 1999945 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9368369, 99403401; Product type cp : cell process; DNA damage-inducible protein YebG complement(1999655..1999945) Escherichia coli ED1a 7141687 YP_002397999.1 CDS purT NC_011745.1 2000079 2001257 D non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis; phosphoribosylglycinamide formyltransferase 2 2000079..2001257 Escherichia coli ED1a 7141688 YP_002398000.1 CDS eda NC_011745.1 2001300 2001941 R catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase complement(2001300..2001941) Escherichia coli ED1a 7141225 YP_002398001.1 CDS edd NC_011745.1 2001978 2003789 R catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate; phosphogluconate dehydratase complement(2001978..2003789) Escherichia coli ED1a 7139772 YP_002398002.1 CDS zwf NC_011745.1 2004024 2005499 R catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase complement(2004024..2005499) Escherichia coli ED1a 7139773 YP_002398003.1 CDS yebK NC_011745.1 2005837 2006706 D Represses the expression of the zwf, eda, glp and gap; DNA-binding transcriptional regulator HexR 2005837..2006706 Escherichia coli ED1a 7143200 YP_002398004.1 CDS pykA NC_011745.1 2006834 2008276 D catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 2006834..2008276 Escherichia coli ED1a 7141689 YP_002398005.1 CDS lpxM NC_011745.1 2008408 2009379 R Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase complement(2008408..2009379) Escherichia coli ED1a 7141229 YP_002398006.1 CDS yebA NC_011745.1 2009498 2010820 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1732206; Product type pe : putative enzyme; hypothetical protein complement(2009498..2010820) Escherichia coli ED1a 7141924 YP_002398007.1 CDS znuA NC_011745.1 2010836 2011768 R involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter periplasmic component complement(2010836..2011768) Escherichia coli ED1a 7141683 YP_002398008.1 CDS znuC NC_011745.1 2011847 2012602 D involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter ATPase 2011847..2012602 Escherichia coli ED1a 7143278 YP_002398009.1 CDS znuB NC_011745.1 2012599 2013384 D involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter membrane component 2012599..2013384 Escherichia coli ED1a 7143280 YP_002398010.1 CDS ruvB NC_011745.1 2013529 2014539 R promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB complement(2013529..2014539) Escherichia coli ED1a 7143279 YP_002398011.1 CDS ruvA NC_011745.1 2014548 2015159 R plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA complement(2014548..2015159) Escherichia coli ED1a 7140147 YP_002398012.1 CDS yebB NC_011745.1 2015434 2016036 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2015434..2016036 Escherichia coli ED1a 7140146 YP_002398013.1 CDS ruvC NC_011745.1 2016038 2016559 R endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase complement(2016038..2016559) Escherichia coli ED1a 7141684 YP_002398014.1 CDS yebC NC_011745.1 2016594 2017334 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2016594..2017334) Escherichia coli ED1a 7140148 YP_002398015.1 CDS ntpA NC_011745.1 2017363 2017806 R converts dATP to dAMP and pyrophosphate; dATP pyrophosphohydrolase complement(2017363..2017806) Escherichia coli ED1a 7141685 YP_002398016.1 CDS aspS NC_011745.1 2017808 2019580 R catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase complement(2017808..2019580) Escherichia coli ED1a 7139937 YP_002398017.1 CDS yecD NC_011745.1 2019890 2020456 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 2019890..2020456 Escherichia coli ED1a 7142651 YP_002398018.1 CDS ECED1_2074 NC_011745.1 2020811 2021059 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative damage-inducible protein dinI-like 2020811..2021059 Escherichia coli ED1a 7141703 YP_002398019.1 CDS eaaA NC_011745.1 2021426 2025451 R Evidence 2b : Function of strongly homologous gene; PubMedId : 10722621, 17220264, 9194704, 9743528; Product type e : enzyme; peptidase S6, IgA endopeptidase from phage origin complement(2021426..2025451) Escherichia coli ED1a 7140898 YP_002398020.1 CDS ECED1_2076 NC_011745.1 2025725 2026195 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10722621; hypothetical protein complement(2025725..2026195) Escherichia coli ED1a 7139761 YP_002398021.1 CDS eibD NC_011745.1 2026283 2027836 R Evidence 2b : Function of strongly homologous gene; PubMedId : 10722621; Product type h : extrachromosomal origin; Immunoglobulin-binding protein from prophage P-EibD complement(2026283..2027836) Escherichia coli ED1a 7140899 YP_002398022.1 CDS ECED1_2079 NC_011745.1 2027817 2028041 R Evidence 6 : Doubtful CDS; hypothetical protein complement(2027817..2028041) Escherichia coli ED1a 7139780 YP_002398023.1 CDS ECED1_2080 NC_011745.1 2028317 2028892 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10722621; Product type h : extrachromosomal origin; hypothetical protein complement(2028317..2028892) Escherichia coli ED1a 7140900 YP_002398024.1 CDS ECED1_2081 NC_011745.1 2028912 2030474 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10722621; Product type h : extrachromosomal origin; putative tail fiber protein from prophage complement(2028912..2030474) Escherichia coli ED1a 7140901 YP_002398025.1 CDS J NC_011745.1 2030659 2034234 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Host specificity protein J (tail component) from phage origin complement(2030659..2034234) Escherichia coli ED1a 7140902 YP_002398026.1 CDS ECED1_2083 NC_011745.1 2034444 2035124 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail assembly protein I complement(2034444..2035124) Escherichia coli ED1a 7142481 YP_002398027.1 CDS ECED1_2084 NC_011745.1 2035022 2036026 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail fiber component K complement(2035022..2036026) Escherichia coli ED1a 7140903 YP_002398028.1 CDS ECED1_2085 NC_011745.1 2035776 2036474 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein L complement(2035776..2036474) Escherichia coli ED1a 7140904 YP_002398029.1 CDS ECED1_2086 NC_011745.1 2036460 2036576 D Evidence 6 : Doubtful CDS; hypothetical protein 2036460..2036576 Escherichia coli ED1a 7140905 YP_002398030.1 CDS ECED1_2087 NC_011745.1 2036474 2036803 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein M complement(2036474..2036803) Escherichia coli ED1a 7140906 YP_002398031.1 CDS ECED1_2088 NC_011745.1 2036800 2039373 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein H complement(2036800..2039373) Escherichia coli ED1a 7140907 YP_002398032.1 CDS ECED1_2089 NC_011745.1 2039354 2039767 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein T complement(2039354..2039767) Escherichia coli ED1a 7140908 YP_002398033.1 CDS ECED1_2090 NC_011745.1 2039794 2040225 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein G complement(2039794..2040225) Escherichia coli ED1a 7140909 YP_002398034.1 CDS ECED1_2091 NC_011745.1 2040239 2040991 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; major tail protein V complement(2040239..2040991) Escherichia coli ED1a 7140910 YP_002398035.1 CDS ECED1_2092 NC_011745.1 2040999 2041394 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein U complement(2040999..2041394) Escherichia coli ED1a 7140911 YP_002398036.1 CDS ECED1_2093 NC_011745.1 2041391 2041966 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein Z (GpZ) complement(2041391..2041966) Escherichia coli ED1a 7140912 YP_002398037.1 CDS ECED1_2094 NC_011745.1 2041982 2042335 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail attachment protein complement(2041982..2042335) Escherichia coli ED1a 7140913 YP_002398038.1 CDS ECED1_2095 NC_011745.1 2042328 2042759 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2042328..2042759) Escherichia coli ED1a 7140914 YP_002398039.1 CDS ECED1_2096 NC_011745.1 2042763 2043791 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; major head protein complement(2042763..2043791) Escherichia coli ED1a 7140915 YP_002398040.1 CDS ECED1_2097 NC_011745.1 2043849 2044196 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; major capsid protein D complement(2043849..2044196) Escherichia coli ED1a 7140916 YP_002398041.1 CDS ECED1_2098 NC_011745.1 2044233 2045738 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; head-tail preconnector protein GP5 complement(2044233..2045738) Escherichia coli ED1a 7140917 YP_002398042.1 CDS ECED1_2099 NC_011745.1 2045728 2047320 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; head protein Gp4 complement(2045728..2047320) Escherichia coli ED1a 7140918 YP_002398043.1 CDS ECED1_2100 NC_011745.1 2047317 2047523 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; head stabilization protein complement(2047317..2047523) Escherichia coli ED1a 7140919 YP_002398044.1 CDS ECED1_2101 NC_011745.1 2047507 2049492 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; terminase large subunit (Gp2) complement(2047507..2049492) Escherichia coli ED1a 7140920 YP_002398045.1 CDS ECED1_2102 NC_011745.1 2049407 2049916 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative terminase small subunit (DNA packaging protein Nu1) from bacteriophage origin complement(2049407..2049916) Escherichia coli ED1a 7140921 YP_002398046.1 CDS ECED1_2103 NC_011745.1 2050078 2050410 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2050078..2050410) Escherichia coli ED1a 7140922 YP_002398047.1 CDS ECED1_2104 NC_011745.1 2050371 2050595 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2050371..2050595) Escherichia coli ED1a 7140923 YP_002398048.1 CDS rz NC_011745.1 2050592 2051086 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Endopeptidase (Lysis protein) from bacteriophage origin complement(2050592..2051086) Escherichia coli ED1a 7140924 YP_002398049.1 CDS ECED1_2106 NC_011745.1 2051088 2051261 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2051088..2051261) Escherichia coli ED1a 7141360 YP_002398050.1 CDS ydfQ NC_011745.1 2051385 2051918 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-associated lysozyme; Qin prophage complement(2051385..2051918) Escherichia coli ED1a 7140925 YP_002398051.1 CDS ECED1_2108 NC_011745.1 2052238 2052873 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2052238..2052873) Escherichia coli ED1a 7139267 YP_002398052.1 CDS essD NC_011745.1 2052878 2053093 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2019562; Product type pe : putative enzyme; putative phage lysis protein S; DLP12 prophage complement(2052878..2053093) Escherichia coli ED1a 7140926 YP_002398053.1 CDS ECED1_2111 NC_011745.1 2055621 2055911 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2055621..2055911) Escherichia coli ED1a 7139814 YP_002398054.1 CDS ECED1_2112 NC_011745.1 2056023 2056430 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative antitermination protein Q complement(2056023..2056430) Escherichia coli ED1a 7140927 YP_002398055.1 CDS ECED1_2113 NC_011745.1 2056433 2057428 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2056433..2057428) Escherichia coli ED1a 7140928 YP_002398056.1 CDS ECED1_2114 NC_011745.1 2057430 2058257 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2057430..2058257) Escherichia coli ED1a 7140929 YP_002398057.1 CDS ECED1_2115 NC_011745.1 2058408 2058803 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative Crossover junction endodeoxyribonuclease complement(2058408..2058803) Escherichia coli ED1a 7140930 YP_002398058.1 CDS ECED1_2116 NC_011745.1 2058800 2059126 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative LexA repressor complement(2058800..2059126) Escherichia coli ED1a 7140931 YP_002398059.1 CDS ECED1_2117 NC_011745.1 2059123 2059809 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage AdoMet-dependent methyltransferase complement(2059123..2059809) Escherichia coli ED1a 7140932 YP_002398060.1 CDS yfdN NC_011745.1 2059776 2060270 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2059776..2060270) Escherichia coli ED1a 7140933 YP_002398061.1 CDS ECED1_2119 NC_011745.1 2060267 2061250 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative replication protein from phage (modular protein) complement(2060267..2061250) Escherichia coli ED1a 7144012 YP_002398062.1 CDS ECED1_2120 NC_011745.1 2061247 2061546 R Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein complement(2061247..2061546) Escherichia coli ED1a 7140934 YP_002398063.1 CDS ECED1_2121 NC_011745.1 2061543 2061767 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2061543..2061767) Escherichia coli ED1a 7140935 YP_002398064.1 CDS ECED1_2122 NC_011745.1 2061764 2062927 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2061764..2062927) Escherichia coli ED1a 7140936 YP_002398065.1 CDS ymfL NC_011745.1 2062924 2063481 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative nucleic acid-binding protein; e14 prophage complement(2062924..2063481) Escherichia coli ED1a 7140937 YP_002398066.1 CDS ECED1_2125 NC_011745.1 2063474 2063734 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative lambda repressor-like DNA-binding domains complement(2063474..2063734) Escherichia coli ED1a 7140980 YP_002398067.1 CDS ECED1_2126 NC_011745.1 2063832 2064524 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative repressor protein CI 2063832..2064524 Escherichia coli ED1a 7140938 YP_002398068.1 CDS ECED1_2127 NC_011745.1 2065084 2066151 D Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 2065084..2066151 Escherichia coli ED1a 7141100 YP_002398069.1 CDS yfdR NC_011745.1 2066242 2066778 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2066242..2066778 Escherichia coli ED1a 7142743 YP_002398070.1 CDS ECED1_2129 NC_011745.1 2066769 2067380 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2066769..2067380 Escherichia coli ED1a 7144013 YP_002398071.1 CDS ECED1_2130 NC_011745.1 2067344 2067601 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2067344..2067601 Escherichia coli ED1a 7139999 YP_002398072.1 CDS ECED1_2131 NC_011745.1 2067598 2068293 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; putative EA22-like protein 2067598..2068293 Escherichia coli ED1a 7140000 YP_002398073.1 CDS ECED1_2132 NC_011745.1 2068214 2068867 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2068214..2068867 Escherichia coli ED1a 7140001 YP_002398074.1 CDS ECED1_2133 NC_011745.1 2068916 2069194 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2068916..2069194 Escherichia coli ED1a 7140002 YP_002398075.1 CDS ECED1_2134 NC_011745.1 2069198 2069344 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2069198..2069344 Escherichia coli ED1a 7140003 YP_002398076.1 CDS ECED1_2135 NC_011745.1 2069353 2069589 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative excisionase 2069353..2069589 Escherichia coli ED1a 7140004 YP_002398077.1 CDS int NC_011745.1 2069645 2070958 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; integrase 2069645..2070958 Escherichia coli ED1a 7140005 YP_002398078.1 CDS yecE NC_011745.1 2070985 2071710 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2129559, 7984428; hypothetical protein 2070985..2071710 Escherichia coli ED1a 7141176 YP_002398079.1 CDS yecN NC_011745.1 2071763 2072158 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2071763..2072158 Escherichia coli ED1a 7140534 YP_002398080.1 CDS yecO NC_011745.1 2072199 2072942 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11746687; Product type e : enzyme; AdoMet-dependent methyltransferase 2072199..2072942 Escherichia coli ED1a 7140541 YP_002398081.1 CDS yecP NC_011745.1 2072939 2073910 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2072939..2073910 Escherichia coli ED1a 7140542 YP_002398082.1 CDS torZ NC_011745.1 2073946 2076375 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 97077292, 11004177; Product type e : enzyme; trimethylamine N-oxide reductase system III, catalytic subunit complement(2073946..2076375) Escherichia coli ED1a 7140543 YP_002398083.1 CDS torY NC_011745.1 2076400 2077500 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20461225, 8919859; Product type c : carrier; TMAO reductase III (TorYZ), cytochrome c-type subunit complement(2076400..2077500) Escherichia coli ED1a 7140799 YP_002398084.1 CDS cutC NC_011745.1 2077888 2078634 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95362641, 7635807; Product type t : transporter; copper homeostasis protein CutC complement(2077888..2078634) Escherichia coli ED1a 7140798 YP_002398085.1 CDS yecM NC_011745.1 2078648 2079214 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12660999; Product type pe : putative enzyme; hypothetical protein complement(2078648..2079214) Escherichia coli ED1a 7142090 YP_002398086.1 CDS argS NC_011745.1 2079430 2081163 D catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 2079430..2081163 Escherichia coli ED1a 7140540 YP_002398087.1 CDS flhE NC_011745.1 2081216 2081608 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8002587, 1482109, 89181349; hypothetical protein complement(2081216..2081608) Escherichia coli ED1a 7142620 YP_002398088.1 CDS flhA NC_011745.1 2081608 2083686 R membrane protein involved in the flagellar export apparatus; flagellar biosynthesis protein FlhA complement(2081608..2083686) Escherichia coli ED1a 7142128 YP_002398089.1 CDS flhB NC_011745.1 2083679 2084827 R membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export; flagellar biosynthesis protein FlhB complement(2083679..2084827) Escherichia coli ED1a 7142124 YP_002398090.1 CDS cheZ NC_011745.1 2085016 2085660 R cytosolic phosphatase which functions in the chemotaxis signal transduction complex by controlling the level of phosphorylated CheY through dephosphorylation; chemotaxis regulator CheZ complement(2085016..2085660) Escherichia coli ED1a 7142125 YP_002398091.1 CDS cheY NC_011745.1 2085671 2086060 R chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble; chemotaxis regulatory protein CheY complement(2085671..2086060) Escherichia coli ED1a 7139343 YP_002398092.1 CDS cheB NC_011745.1 2086075 2087124 R regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins; chemotaxis-specific methylesterase complement(2086075..2087124) Escherichia coli ED1a 7139342 YP_002398093.1 CDS cheR NC_011745.1 2087127 2087987 R methylates the MCP; chemotaxis methyltransferase CheR complement(2087127..2087987) Escherichia coli ED1a 7139339 YP_002398094.1 CDS tar NC_011745.1 2088278 2089939 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90094243, 92165727, 6305515, 9315712; Product type r : regulator; methyl-accepting chemotaxis protein II complement(2088278..2089939) Escherichia coli ED1a 7141509 YP_002398095.1 CDS cheW NC_011745.1 2090084 2090587 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91126073, 91296802, 91317710, 2002011, 3510184; Product type r : regulator; purine-binding chemotaxis protein complement(2090084..2090587) Escherichia coli ED1a 7140754 YP_002398096.1 CDS cheA NC_011745.1 2090608 2092572 R chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY; sensory histidine kinase/signal sensing protein; CheA is the histidine kinase component; chemotaxis protein CheA complement(2090608..2092572) Escherichia coli ED1a 7139341 YP_002398097.1 CDS motB NC_011745.1 2092577 2093503 R with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotB complement(2092577..2093503) Escherichia coli ED1a 7139338 YP_002398098.1 CDS motA NC_011745.1 2093500 2094387 R With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotA complement(2093500..2094387) Escherichia coli ED1a 7139013 YP_002398099.1 CDS flhC NC_011745.1 2094514 2095092 R With FlhD is involved in the activation of class 2 flagellar genes and as well as a number of other genetic systems; transcriptional activator FlhC complement(2094514..2095092) Escherichia coli ED1a 7139012 YP_002398100.1 CDS flhD NC_011745.1 2095095 2095454 R with FlhC is involved in the activation of class 2 flagellar genes and is involved in the regulation of a number of other genetic systems; transcriptional activator FlhD complement(2095095..2095454) Escherichia coli ED1a 7142126 YP_002398101.1 CDS yecG NC_011745.1 2096225 2096653 D ppGpp-dependent; membrane-associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress; universal stress protein UspC 2096225..2096653 Escherichia coli ED1a 7142127 YP_002398102.1 CDS otsA NC_011745.1 2096660 2098084 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92078100, 92121128, 93302496, 8045430; Product type e : enzyme; trehalose-6-phosphate synthase complement(2096660..2098084) Escherichia coli ED1a 7140536 YP_002398103.1 CDS otsB NC_011745.1 2098059 2098859 R biosynthetic; catalyzes the formation of trehalose and phosphate from trehalose-6-phosphate; expression is increased under osmotic stress and induced during the transition to stationary phase and by decreased temperature; trehalose-6-phosphate phosphatase complement(2098059..2098859) Escherichia coli ED1a 7139991 YP_002398104.1 CDS araH NC_011745.1 2099026 2100015 R Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose transporter permease complement(2099026..2100015) Escherichia coli ED1a 7139992 YP_002398105.1 CDS araG NC_011745.1 2100027 2101541 R Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose transporter ATP-binding protein complement(2100027..2101541) Escherichia coli ED1a 7142603 YP_002398106.1 CDS araF NC_011745.1 2101611 2102645 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89255061, 90375534, 2445996, 326784, 326785, 6885805, 7031057, 9298646; Product type t : transporter; L-arabinose ABC transporter subunit periplasmic-binding protein complement(2101611..2102645) Escherichia coli ED1a 7142602 YP_002398107.1 CDS insB NC_011745.1 2103261 2103764 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' complement(2103261..2103764) Escherichia coli ED1a 7142601 YP_002398108.1 CDS insA NC_011745.1 2103683 2103958 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; Transposase ORF A, IS1 complement(2103683..2103958) Escherichia coli ED1a 7141143 YP_002398109.1 CDS yecI NC_011745.1 2104168 2104671 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative ferritin-like protein 2104168..2104671 Escherichia coli ED1a 7141121 YP_002398110.1 CDS yecJ NC_011745.1 2104750 2105001 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2104750..2105001) Escherichia coli ED1a 7140538 YP_002398111.1 CDS ECED1_2171 NC_011745.1 2105113 2105259 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2105113..2105259 Escherichia coli ED1a 7140755 YP_002398112.1 CDS yecR NC_011745.1 2105465 2105788 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2105465..2105788 Escherichia coli ED1a 7140006 YP_002398113.1 CDS ftn NC_011745.1 2105959 2106456 D cytoplasmic iron storage protein; ferritin 2105959..2106456 Escherichia coli ED1a 7140544 YP_002398114.1 CDS yecH NC_011745.1 2106494 2106733 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2106494..2106733) Escherichia coli ED1a 7142187 YP_002398115.1 CDS tyrP NC_011745.1 2106924 2108135 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89008121, 2022620; Product type t : transporter; tyrosine transporter 2106924..2108135 Escherichia coli ED1a 7140537 YP_002398116.1 CDS yecA NC_011745.1 2108197 2108862 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2108197..2108862) Escherichia coli ED1a 7140852 YP_002398117.1 CDS pgsA NC_011745.1 2109512 2110060 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 381294, 7007311, 94253011, 1323047, 3003065, 8917447; Product type e : enzyme; phosphatidylglycerophosphate synthetase complement(2109512..2110060) Escherichia coli ED1a 7140624 YP_002398118.1 CDS uvrC NC_011745.1 2110117 2111949 R The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C complement(2110117..2111949) Escherichia coli ED1a 7144080 YP_002398119.1 CDS uvrY NC_011745.1 2111946 2112602 R in Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system; in Salmonella SirA and BarA regulate virulence gene expression also via the Csr system; response regulator complement(2111946..2112602) Escherichia coli ED1a 7139152 YP_002398120.1 CDS yecF NC_011745.1 2113061 2113285 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3515318, 7567469; hypothetical protein 2113061..2113285 Escherichia coli ED1a 7139154 YP_002398121.1 CDS sdiA NC_011745.1 2113353 2114075 R regulates genes involved in cell division; DNA-binding transcriptional activator SdiA complement(2113353..2114075) Escherichia coli ED1a 7140535 YP_002398122.1 CDS yecC NC_011745.1 2114305 2115057 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative amino-acid ABC transporter ATP-binding protein YecC complement(2114305..2115057) Escherichia coli ED1a 7141384 YP_002398123.1 CDS yecS NC_011745.1 2115054 2115722 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter permease complement(2115054..2115722) Escherichia coli ED1a 7141702 YP_002398124.1 CDS yedO NC_011745.1 2115737 2116723 R catalyzes the formation of pyruvate from D-cysteine; D-cysteine desulfhydrase complement(2115737..2116723) Escherichia coli ED1a 7140545 YP_002398125.1 CDS fliY NC_011745.1 2116828 2117628 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96125225, 8450713, 8774726, 9298646, 9740056; Product type t : transporter; cystine transporter subunit complement(2116828..2117628) Escherichia coli ED1a 7140553 YP_002398126.1 CDS fliZ NC_011745.1 2117716 2118267 R expression activator of the class 2 type of flagellar operons, essential to achieve maximal cell motility; activator of type 1 fimbrial gene expression; cell density-responsive regulator; FliZ in Salmonella typhimurium induces HilA, an activator of invasion genes necessary to achieve full virulence; flagella biosynthesis protein FliZ complement(2117716..2118267) Escherichia coli ED1a 7142148 YP_002398127.1 CDS fliA NC_011745.1 2118313 2119032 R sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes; flagellar biosynthesis sigma factor complement(2118313..2119032) Escherichia coli ED1a 7142149 YP_002398128.1 CDS fliC NC_011745.1 2119197 2120657 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7690024; Product type s : structure; Flagellin (Phase 1-C flagellin) complement(2119197..2120657) Escherichia coli ED1a 7142129 YP_002398129.1 CDS fliD NC_011745.1 2120834 2122324 D involved in flagellin assembly; flagellar capping protein 2120834..2122324 Escherichia coli ED1a 7142130 YP_002398130.1 CDS fliS NC_011745.1 2122339 2122749 D flagellin specific chaperone; flagellar protein FliS 2122339..2122749 Escherichia coli ED1a 7142131 YP_002398131.1 CDS fliT NC_011745.1 2122749 2123114 D binds flagellar cap subunits (FliD) and seems to prevents their oligomerization prior to its translocation through the flagellum-specific type III export pathway; acts as a repressor of flagellar class 2 operons by preventing FlhD2C2 to bind the promoter and inhibiting the FlhD2C2-dependent transcription; member of the type III cytoplasmic chaperone family; flagellar biosynthesis protein FliT 2122749..2123114 Escherichia coli ED1a 7142146 YP_002398132.1 CDS amyA NC_011745.1 2123192 2124679 D converts 1,4-alpha-D-glucans to maltodextrin; cytoplasmic alpha-amylase 2123192..2124679 Escherichia coli ED1a 7142147 YP_002398133.1 CDS yedD NC_011745.1 2124713 2125126 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2124713..2125126) Escherichia coli ED1a 7142581 YP_002398134.1 CDS yedE NC_011745.1 2125313 2126518 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; putative inner membrane protein 2125313..2126518 Escherichia coli ED1a 7140547 YP_002398135.1 CDS yedF NC_011745.1 2126515 2126748 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2126515..2126748 Escherichia coli ED1a 7140548 YP_002398136.1 CDS yedK NC_011745.1 2126855 2127526 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2126855..2127526 Escherichia coli ED1a 7140549 YP_002398137.1 CDS ydcM NC_011745.1 2127566 2128774 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transposase complement(2127566..2128774) Escherichia coli ED1a 7140552 YP_002398138.1 CDS ECED1_2198 NC_011745.1 2128752 2128898 R Evidence 6 : Doubtful CDS; hypothetical protein complement(2128752..2128898) Escherichia coli ED1a 7139228 YP_002398139.1 CDS yncK NC_011745.1 2128782 2129069 D Evidence 7 : Gene remnant; hypothetical protein 2128782..2129069 Escherichia coli ED1a 7140007 YP_002398140.1 CDS ECED1_2200 NC_011745.1 2129788 2129961 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(2129788..2129961) Escherichia coli ED1a 7141000 YP_002398141.1 CDS ybcM NC_011745.1 2130161 2130862 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12270809; Product type pr : putative regulator; putative DNA-binding transcriptional regulator; DLP12 prophage complement(2130161..2130862) Escherichia coli ED1a 7140008 YP_002398142.1 CDS ybcL NC_011745.1 2130967 2131518 R DLP12 prophage; similar to PEBP/RK1P protein family in eukaryotes that inhibits MEK phosphorylation by Raf-1; crystal structure suggests similar properties but exact function is unknown; putative kinase inhibitor complement(2130967..2131518) Escherichia coli ED1a 7138921 YP_002398143.1 CDS emrE NC_011745.1 2131687 2132199 R member of the small MDR (multidrug resistance) family of transporters; in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin; proton-dependent secondary transporter which exchanges protons for compound translocation; multidrug efflux protein complement(2131687..2132199) Escherichia coli ED1a 7138920 YP_002398144.1 CDS fliE NC_011745.1 2132353 2132667 R forms a junction between the M-ring and FlgB during flagella biosynthesis; flagellar hook-basal body protein FliE complement(2132353..2132667) Escherichia coli ED1a 7139788 YP_002398145.1 CDS fliF NC_011745.1 2132882 2134540 D the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod; flagellar MS-ring protein 2132882..2134540 Escherichia coli ED1a 7142132 YP_002398146.1 CDS fliG NC_011745.1 2134533 2135528 D One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein G 2134533..2135528 Escherichia coli ED1a 7142133 YP_002398147.1 CDS fliH NC_011745.1 2135521 2136207 D binds to and inhibits the function of flagella specific ATPase FliI; flagellar assembly protein H 2135521..2136207 Escherichia coli ED1a 7142134 YP_002398148.1 CDS fliI NC_011745.1 2136207 2137580 D involved in type III protein export during flagellum assembly; flagellum-specific ATP synthase 2136207..2137580 Escherichia coli ED1a 7142135 YP_002398149.1 CDS fliJ NC_011745.1 2137599 2138042 D rod/hook and filament chaperone; flagellar biosynthesis chaperone 2137599..2138042 Escherichia coli ED1a 7142136 YP_002398150.1 CDS fliK NC_011745.1 2138039 2139166 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1482109, 8631687; Product type s : structure; flagellar hook-length control protein 2138039..2139166 Escherichia coli ED1a 7142137 YP_002398151.1 CDS fliL NC_011745.1 2139271 2139735 D interacts with cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring; flagellar basal body-associated protein FliL 2139271..2139735 Escherichia coli ED1a 7142138 YP_002398152.1 CDS fliM NC_011745.1 2139740 2140744 D with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation; flagellar motor switch protein FliM 2139740..2140744 Escherichia coli ED1a 7142139 YP_002398153.1 CDS fliN NC_011745.1 2140741 2141154 D One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein FliN 2140741..2141154 Escherichia coli ED1a 7142140 YP_002398154.1 CDS fliO NC_011745.1 2141157 2141522 D with FlhA, FlhB, FliP, FliQ and FliR is one of the membrane components of the flagellar export apparatus; flagellar biosynthesis protein FliO 2141157..2141522 Escherichia coli ED1a 7142141 YP_002398155.1 CDS fliP NC_011745.1 2141522 2142259 D FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliP 2141522..2142259 Escherichia coli ED1a 7142142 YP_002398156.1 CDS fliQ NC_011745.1 2142269 2142538 D with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliQ 2142269..2142538 Escherichia coli ED1a 7142143 YP_002398157.1 CDS fliR NC_011745.1 2142546 2143331 D FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliR 2142546..2143331 Escherichia coli ED1a 7142144 YP_002398158.1 CDS rcsA NC_011745.1 2143621 2144244 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14514676, 14766922, 20167175, 90130299, 91154130, 92048476, 9882673, 7534408; Product type r : regulator; DNA-binding transcriptional activator, co-regulator with RcsB 2143621..2144244 Escherichia coli ED1a 7142145 YP_002398159.1 CDS dsrB NC_011745.1 2144288 2144476 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 96324407, 7534408; hypothetical protein complement(2144288..2144476) Escherichia coli ED1a 7141263 YP_002398160.1 CDS yodD NC_011745.1 2144639 2144866 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2144639..2144866 Escherichia coli ED1a 7140530 YP_002398161.1 CDS yedP NC_011745.1 2145164 2145979 D catalyzes the hydrolysis of mannosyl-3-phosphoglycerate to form the osmolyte mannosylglycerate; mannosyl-3-phosphoglycerate phosphatase 2145164..2145979 Escherichia coli ED1a 7140528 YP_002398162.1 CDS yedQ NC_011745.1 2145976 2147670 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16530465; Product type pe : putative enzyme; putative diguanylate cyclase complement(2145976..2147670) Escherichia coli ED1a 7140554 YP_002398163.1 CDS ECED1_2223 NC_011745.1 2147591 2147779 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2147591..2147779) Escherichia coli ED1a 7140555 YP_002398164.1 CDS yodC NC_011745.1 2147841 2148023 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2147841..2148023) Escherichia coli ED1a 7140009 YP_002398165.1 CDS yedI NC_011745.1 2148102 2149019 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(2148102..2149019) Escherichia coli ED1a 7140264 YP_002398166.1 CDS yedA NC_011745.1 2149192 2150112 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2149192..2150112 Escherichia coli ED1a 7140550 YP_002398167.1 CDS vsr NC_011745.1 2150101 2150571 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90330522, 92049708, 94049122, 10360178, 10612397, 10871403, 2527357; Product type e : enzyme; DNA mismatch endonuclease of very short patch repair complement(2150101..2150571) Escherichia coli ED1a 7140546 YP_002398168.1 CDS dcm NC_011745.1 2150552 2151970 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90280700, 91285397, 93367813, 2198248, 2527357; Product type e : enzyme; DNA cytosine methylase complement(2150552..2151970) Escherichia coli ED1a 7139168 YP_002398169.1 CDS yedJ NC_011745.1 2152037 2152732 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7567469; Product type pe : putative enzyme; hypothetical protein complement(2152037..2152732) Escherichia coli ED1a 7143069 YP_002398170.1 CDS yedR NC_011745.1 2152772 2153137 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(2152772..2153137) Escherichia coli ED1a 7140551 YP_002398171.1 CDS ECED1_2231 NC_011745.1 2153633 2154775 D Evidence 2b : Function of strongly homologous gene; Product type pm : putative membrane component; outer membrane protein F 2153633..2154775 Escherichia coli ED1a 7140112 YP_002398172.1 CDS hchA NC_011745.1 2155367 2156218 D Hsp31 stabilizes early unfolding protein intermediates under severe heat stress; chaperone protein HchA 2155367..2156218 Escherichia coli ED1a 7140010 YP_002398173.1 CDS yedV NC_011745.1 2156326 2157684 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15522865; Product type rc : receptor; sensory kinase in two-component regulatory system with YedW complement(2156326..2157684) Escherichia coli ED1a 7139855 YP_002398174.1 CDS yedW NC_011745.1 2157684 2158355 R induced by CusR in the presence of copper; YedW induces the expression of the upstream gene yedV (encoding a sensor kinase) as well as yedW; yedVW is one of four copper regulons found in E. coli; part of the copper homeostasis mechanism; confers resistance to copper and several drugs when induced; transcriptional regulatory protein YedW complement(2157684..2158355) Escherichia coli ED1a 7140557 YP_002398175.1 CDS yedX NC_011745.1 2158488 2158901 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2158488..2158901 Escherichia coli ED1a 7140558 YP_002398176.1 CDS yedY NC_011745.1 2159010 2160014 D in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ; putative sulfite oxidase subunit YedY 2159010..2160014 Escherichia coli ED1a 7140559 YP_002398177.1 CDS yedZ NC_011745.1 2160015 2160650 D in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme; putative sulfite oxidase subunit YedZ 2160015..2160650 Escherichia coli ED1a 7140560 YP_002398178.1 CDS yodA NC_011745.1 2160907 2161557 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12077457, 12480884, 12909634, 9579078; hypothetical protein 2160907..2161557 Escherichia coli ED1a 7140561 YP_002398179.1 CDS ECED1_2239 NC_011745.1 2161667 2161816 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2161667..2161816 Escherichia coli ED1a 7140262 YP_002398180.1 CDS yodB NC_011745.1 2161900 2162430 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16042411; Product type pc : putative carrier; putative cytochrome 2161900..2162430 Escherichia coli ED1a 7140011 YP_002398181.1 CDS yeeI NC_011745.1 2163183 2163980 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2163183..2163980 Escherichia coli ED1a 7140623 YP_002398182.1 CDS int NC_011745.1 2164318 2165580 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; integrase 2164318..2165580 Escherichia coli ED1a 7140787 YP_002398183.1 CDS irp NC_011745.1 2165774 2167078 R catalyzes the conversion of chorismate to salicylate in the biosynthesis of the siderophore yersiniabactin; salicylate synthase Irp9 complement(2165774..2167078) Escherichia coli ED1a 7141177 YP_002398184.1 CDS irp NC_011745.1 2167106 2168509 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; yersiniabactin-iron transporter permease YbtX complement(2167106..2168509) Escherichia coli ED1a 7142448 YP_002398185.1 CDS irp NC_011745.1 2168379 2170208 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10231486, 11320115; Product type t : transporter; yersiniabactin-iron ABC transporter permease ATP-binding protein YbtQ complement(2168379..2170208) Escherichia coli ED1a 7142449 YP_002398186.1 CDS irp NC_011745.1 2170168 2171970 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10231486, 11320115; Product type t : transporter; yersiniabactin-iron ABC transporter permease ATP-binding protein YbtP complement(2170168..2171970) Escherichia coli ED1a 7142450 YP_002398187.1 CDS ybtA NC_011745.1 2172137 2173096 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8930916; Product type r : regulator; AraC family transcriptional regulator 2172137..2173096 Escherichia coli ED1a 7142451 YP_002398188.1 CDS irp NC_011745.1 2173269 2179394 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15719346, 15582399, 8366034, 11927258, 9709002; Product type e : enzyme; High-molecular-weight nonribosomal peptide/polyketide synthetase 2 2173269..2179394 Escherichia coli ED1a 7142698 YP_002398189.1 CDS irp NC_011745.1 2179482 2188973 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15719346, 15582399, 11927258; Product type e : enzyme; High-molecular-weight nonribosomal peptide/polyketide synthetase 1 2179482..2188973 Escherichia coli ED1a 7142452 YP_002398190.1 CDS irp NC_011745.1 2188910 2190070 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11927258; Product type e : enzyme; Thiazolinyl-S-HMWP1 reductase YbtU 2188910..2190070 Escherichia coli ED1a 7142453 YP_002398191.1 CDS irp NC_011745.1 2190067 2190870 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative thioesterase YbtT 2190067..2190870 Escherichia coli ED1a 7142454 YP_002398192.1 CDS irp NC_011745.1 2190874 2192451 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9818149, 11927258, 9709002; Product type e : enzyme; salicyl-AMP ligase YbtE 2190874..2192451 Escherichia coli ED1a 7142455 YP_002398193.1 CDS fyuA NC_011745.1 2192582 2194603 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7896707, 7984105; Product type rc : receptor; yersiniabactin/pesticin outer membrane receptor (IRPC) 2192582..2194603 Escherichia coli ED1a 7142456 YP_002398194.1 CDS ECED1_2255 NC_011745.1 2195417 2196400 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2195417..2196400 Escherichia coli ED1a 7143137 YP_002398195.1 CDS ECED1_2256 NC_011745.1 2196744 2196929 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2196744..2196929 Escherichia coli ED1a 7140012 YP_002398196.1 CDS ECED1_2257 NC_011745.1 2196914 2197495 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2196914..2197495 Escherichia coli ED1a 7140013 YP_002398197.1 CDS ECED1_2258 NC_011745.1 2197485 2197694 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative lambdoid prophage protein from the DksA/TraR family with a zinc finger 2197485..2197694 Escherichia coli ED1a 7140014 YP_002398198.1 CDS ECED1_2259 NC_011745.1 2197937 2198065 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2197937..2198065 Escherichia coli ED1a 7140015 YP_002398199.1 CDS ECED1_2260 NC_011745.1 2198634 2198867 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2198634..2198867 Escherichia coli ED1a 7140016 YP_002398200.1 CDS ECED1_2261 NC_011745.1 2198922 2199650 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14731283, 15546668, 16428391; Product type ps : putative structure; putative type IV secretory pathway VirB1 component 2198922..2199650 Escherichia coli ED1a 7140017 YP_002398201.1 CDS ECED1_2262 NC_011745.1 2199650 2199943 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14731283, 15546668, 16428391; Product type ps : putative structure; putative type IV secretory pathway VirB2 component 2199650..2199943 Escherichia coli ED1a 7140018 YP_002398202.1 CDS ECED1_2263 NC_011745.1 2199956 2202694 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14731283, 15546668, 16428391; Product type ps : putative structure; putative type IV secretory pathway VirB4 component 2199956..2202694 Escherichia coli ED1a 7140019 YP_002398203.1 CDS ECED1_2264 NC_011745.1 2202712 2203419 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14731283, 15546668, 16428391; Product type ps : putative structure; putative type IV secretory pathway VirB5 component 2202712..2203419 Escherichia coli ED1a 7140020 YP_002398204.1 CDS ECED1_2265 NC_011745.1 2203427 2203669 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14731283, 15546668, 16428391; hypothetical protein 2203427..2203669 Escherichia coli ED1a 7140021 YP_002398205.1 CDS ECED1_2266 NC_011745.1 2203673 2204746 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14731283, 15546668, 16428391; Product type ps : putative structure; putative type IV secretory pathway VirB6 component 2203673..2204746 Escherichia coli ED1a 7140022 YP_002398206.1 CDS ECED1_2267 NC_011745.1 2204968 2205651 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14731283, 15546668, 16428391; Product type ps : putative structure; putative type IV secretory pathway VirB8 component 2204968..2205651 Escherichia coli ED1a 7140023 YP_002398207.1 CDS ECED1_2268 NC_011745.1 2205648 2206556 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14731283, 15546668, 16428391; Product type ps : putative structure; putative type IV secretory pathway VirB9 component 2205648..2206556 Escherichia coli ED1a 7140024 YP_002398208.1 CDS ECED1_2269 NC_011745.1 2206586 2207842 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14731283, 15546668, 16428391; Product type ps : putative structure; putative type IV secretory pathway VirB10 component 2206586..2207842 Escherichia coli ED1a 7140025 YP_002398209.1 CDS ECED1_2270 NC_011745.1 2207832 2208857 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14731283, 15546668, 16428391, 2370849, 2233252; Product type ps : putative structure; putative type IV secretory pathway VirB11 component 2207832..2208857 Escherichia coli ED1a 7140026 YP_002398210.1 CDS ECED1_2271 NC_011745.1 2208854 2209252 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2208854..2209252 Escherichia coli ED1a 7140027 YP_002398211.1 CDS kikA NC_011745.1 2209288 2209593 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14731283, 8029323, 7891554, 8812785, 1569033; Product type h : extrachromosomal origin; putative plasmid conjugation protein 2209288..2209593 Escherichia coli ED1a 7140028 YP_002398212.1 CDS ECED1_2273 NC_011745.1 2209627 2209932 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14731283; hypothetical protein 2209627..2209932 Escherichia coli ED1a 7142511 YP_002398213.1 CDS ECED1_2274 NC_011745.1 2210612 2212501 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14731283, 10940031; Product type h : extrachromosomal origin; putative MobB mobilization protein 2210612..2212501 Escherichia coli ED1a 7140029 YP_002398214.1 CDS ECED1_2275 NC_011745.1 2212511 2213257 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14731283, 10940031, 11251827; Product type h : extrachromosomal origin; putative MobC mobilization protein 2212511..2213257 Escherichia coli ED1a 7140030 YP_002398215.1 CDS ECED1_2276 NC_011745.1 2213451 2214497 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14731283, 10686096; Product type pc : putative carrier; putative Antirestriction protein ardC complement(2213451..2214497) Escherichia coli ED1a 7140031 YP_002398216.1 CDS ECED1_2277 NC_011745.1 2215060 2215323 R Evidence 2b : Function of strongly homologous gene; PubMedId : 7737514, 1718819, 15126494, 7737514; Product type pe : putative enzyme; Transposase, ORF A, IS3 family, IS407 group complement(2215060..2215323) Escherichia coli ED1a 7140032 YP_002398217.1 CDS ECED1_2278 NC_011745.1 2215465 2216523 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2215465..2216523) Escherichia coli ED1a 7140033 YP_002398218.1 CDS ECED1_2279 NC_011745.1 2216529 2218313 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2216529..2218313) Escherichia coli ED1a 7140034 YP_002398219.1 CDS ECED1_2280 NC_011745.1 2218310 2219875 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative type I restriction modification system protein complement(2218310..2219875) Escherichia coli ED1a 7140035 YP_002398220.1 CDS ECED1_2281 NC_011745.1 2219872 2221545 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8412658; Product type pe : putative enzyme; putative HsdM; type I restriction modification enzyme methylase subunit complement(2219872..2221545) Escherichia coli ED1a 7140036 YP_002398221.1 CDS yeeJ NC_011745.1 2222625 2229728 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15659678; Product type f : factor; adhesin 2222625..2229728 Escherichia coli ED1a 7140037 YP_002398222.1 CDS shiA NC_011745.1 2231357 2232673 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 5332864, 9524262; Product type t : transporter; shikimate transporter 2231357..2232673 Escherichia coli ED1a 7140039 YP_002398223.1 CDS amn NC_011745.1 2232775 2234229 D Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile; AMP nucleosidase 2232775..2234229 Escherichia coli ED1a 7143795 YP_002398224.1 CDS yeeN NC_011745.1 2234572 2235288 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2234572..2235288 Escherichia coli ED1a 7143705 YP_002398225.1 CDS ECED1_2290 NC_011745.1 2235527 2235673 D Evidence 6 : Doubtful CDS; hypothetical protein 2235527..2235673 Escherichia coli ED1a 7140568 YP_002398226.1 CDS yeeO NC_011745.1 2235917 2237560 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16042411; Product type pt : putative transporter; hypothetical protein complement(2235917..2237560) Escherichia coli ED1a 7140622 YP_002398227.1 CDS int NC_011745.1 2237821 2239095 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Prophage integrase 2237821..2239095 Escherichia coli ED1a 7140788 YP_002398228.1 CDS ECED1_2294 NC_011745.1 2239142 2240596 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative SpnT protein complement(2239142..2240596) Escherichia coli ED1a 7141178 YP_002398229.1 CDS ECED1_2295 NC_011745.1 2240713 2242611 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; site-specific DNA-methyltransferase, component of type III restriction-modification system 2240713..2242611 Escherichia coli ED1a 7140041 YP_002398230.1 CDS ECED1_2296 NC_011745.1 2242621 2245581 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Type III restriction-modification system site-specific deoxyribonuclease 2242621..2245581 Escherichia coli ED1a 7140042 YP_002398231.1 CDS ECED1_2297 NC_011745.1 2245708 2247279 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative PilV-like protein complement(2245708..2247279) Escherichia coli ED1a 7140043 YP_002398232.1 CDS ECED1_2298 NC_011745.1 2247584 2247907 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2247584..2247907) Escherichia coli ED1a 7140044 YP_002398233.1 CDS ECED1_2299 NC_011745.1 2247991 2248506 R Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein complement(2247991..2248506) Escherichia coli ED1a 7140045 YP_002398234.1 CDS ECED1_2300 NC_011745.1 2248553 2249062 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(2248553..2249062) Escherichia coli ED1a 7140046 YP_002398235.1 CDS ECED1_2301 NC_011745.1 2250056 2250403 R Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein complement(2250056..2250403) Escherichia coli ED1a 7140047 YP_002398236.1 CDS ECED1_2302 NC_011745.1 2250400 2250594 R Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein complement(2250400..2250594) Escherichia coli ED1a 7140048 YP_002398237.1 CDS ECED1_2303 NC_011745.1 2250746 2251747 D Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 2250746..2251747 Escherichia coli ED1a 7140049 YP_002398238.1 CDS ECED1_2304 NC_011745.1 2252468 2253949 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative mobilization protein 2252468..2253949 Escherichia coli ED1a 7140050 YP_002398239.1 CDS ECED1_2305 NC_011745.1 2254094 2255050 R Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; putative Radical SAM superfamily complement(2254094..2255050) Escherichia coli ED1a 7140051 YP_002398240.1 CDS ECED1_2306 NC_011745.1 2255050 2256069 R Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; putative Radical SAM superfamily complement(2255050..2256069) Escherichia coli ED1a 7140052 YP_002398241.1 CDS ECED1_2307 NC_011745.1 2256059 2256274 R Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein complement(2256059..2256274) Escherichia coli ED1a 7140053 YP_002398242.1 CDS ECED1_2308 NC_011745.1 2256344 2256490 R Evidence 6 : Doubtful CDS; Product type h : extrachromosomal origin; hypothetical protein complement(2256344..2256490) Escherichia coli ED1a 7140054 YP_002398243.1 CDS ECED1_2309 NC_011745.1 2257134 2257439 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2257134..2257439) Escherichia coli ED1a 7140055 YP_002398244.1 CDS ECED1_2310 NC_011745.1 2257420 2257980 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative lipoprotein complement(2257420..2257980) Escherichia coli ED1a 7140056 YP_002398245.1 CDS ECED1_2311 NC_011745.1 2257986 2258552 R Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein complement(2257986..2258552) Escherichia coli ED1a 7140057 YP_002398246.1 CDS ECED1_2312 NC_011745.1 2258726 2259073 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative transcriptional regulator 2258726..2259073 Escherichia coli ED1a 7140058 YP_002398247.1 CDS ECED1_2313 NC_011745.1 2259980 2260549 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative replication protein 2259980..2260549 Escherichia coli ED1a 7140059 YP_002398248.1 CDS ECED1_2314 NC_011745.1 2260546 2261346 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2260546..2261346 Escherichia coli ED1a 7140060 YP_002398249.1 CDS ECED1_2315 NC_011745.1 2261579 2262559 D Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 2261579..2262559 Escherichia coli ED1a 7140061 YP_002398250.1 CDS ECED1_2316 NC_011745.1 2262696 2263175 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2262696..2263175 Escherichia coli ED1a 7140062 YP_002398251.1 CDS hns NC_011745.1 2263334 2263738 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89056689, 94335643, 95267838, 95286558, 99355427, 2404280, 11298273; Product type r : regulator; DNA-binding protein H-NS (Histone-like protein HLP-II) 2263334..2263738 Escherichia coli ED1a 7140063 YP_002398252.1 CDS ECED1_2318 NC_011745.1 2263864 2264244 R Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein complement(2263864..2264244) Escherichia coli ED1a 7139905 YP_002398253.1 CDS ECED1_2319 NC_011745.1 2264296 2264586 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2264296..2264586) Escherichia coli ED1a 7140064 YP_002398254.1 CDS ECED1_2320 NC_011745.1 2264665 2265003 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2264665..2265003) Escherichia coli ED1a 7140065 YP_002398255.1 CDS ECED1_2321 NC_011745.1 2264990 2265319 R Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein complement(2264990..2265319) Escherichia coli ED1a 7140066 YP_002398256.1 CDS ECED1_2322 NC_011745.1 2265335 2265553 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative DNA binding protein from phage origin complement(2265335..2265553) Escherichia coli ED1a 7140067 YP_002398257.1 CDS ECED1_2323 NC_011745.1 2265701 2266564 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2265701..2266564) Escherichia coli ED1a 7140068 YP_002398258.1 CDS cbl NC_011745.1 2267005 2267955 R LysR-type transcriptional regulator similar to CysB; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates two operons consisting of ABC transporters that are part of the cys regulon; regulated by CysB; transcriptional regulator Cbl complement(2267005..2267955) Escherichia coli ED1a 7140069 YP_002398259.1 CDS nac NC_011745.1 2268057 2268974 R Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation; nitrogen assimilation transcriptional regulator complement(2268057..2268974) Escherichia coli ED1a 7139308 YP_002398260.1 CDS erfK NC_011745.1 2269432 2270364 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9298646; hypothetical protein complement(2269432..2270364) Escherichia coli ED1a 7140789 YP_002398261.1 CDS cobT NC_011745.1 2270429 2271508 R catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase complement(2270429..2271508) Escherichia coli ED1a 7139810 YP_002398262.1 CDS cobS NC_011745.1 2271520 2272263 R catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole; cobalamin synthase complement(2271520..2272263) Escherichia coli ED1a 7142034 YP_002398263.1 CDS cobU NC_011745.1 2272260 2272805 R catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP; adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase complement(2272260..2272805) Escherichia coli ED1a 7142033 YP_002398264.1 CDS ECED1_2332 NC_011745.1 2273270 2273434 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2273270..2273434) Escherichia coli ED1a 7140070 YP_002398265.1 CDS ECED1_2334 NC_011745.1 2275552 2275677 R Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF A, IS911 (fragment) complement(2275552..2275677) Escherichia coli ED1a 7140072 YP_002398266.1 CDS ECED1_2335 NC_011745.1 2275712 2275855 R Evidence 7 : Gene remnant; hypothetical protein complement(2275712..2275855) Escherichia coli ED1a 7140073 YP_002398267.1 CDS ECED1_2336 NC_011745.1 2275902 2276054 D Evidence 6 : Doubtful CDS; hypothetical protein 2275902..2276054 Escherichia coli ED1a 7140074 YP_002398268.1 CDS ECED1_2337 NC_011745.1 2276161 2276277 D Evidence 6 : Doubtful CDS; hypothetical protein 2276161..2276277 Escherichia coli ED1a 7140075 YP_002398269.1 CDS ECED1_2340 NC_011745.1 2277701 2278459 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2277701..2278459 Escherichia coli ED1a 7140078 YP_002398270.1 CDS ECED1_2341 NC_011745.1 2278516 2279481 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2278516..2279481 Escherichia coli ED1a 7140079 YP_002398271.1 CDS ECED1_2342 NC_011745.1 2279484 2280518 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphotriesterase-related protein 2279484..2280518 Escherichia coli ED1a 7142826 YP_002398272.1 CDS ECED1_2347 NC_011745.1 2282833 2283240 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2282833..2283240) Escherichia coli ED1a 7143285 YP_002398273.1 CDS ECED1_2348 NC_011745.1 2283228 2283635 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2283228..2283635) Escherichia coli ED1a 7143286 YP_002398274.1 CDS ECED1_2349 NC_011745.1 2283889 2284494 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2283889..2284494) Escherichia coli ED1a 7143287 YP_002398275.1 CDS ECED1_2351 NC_011745.1 2285285 2285653 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2285285..2285653 Escherichia coli ED1a 7143288 YP_002398276.1 CDS ECED1_2352 NC_011745.1 2285735 2286214 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7519596; Product type h : extrachromosomal origin; putative antirestriction protein of plasmid origin 2285735..2286214 Escherichia coli ED1a 7143289 YP_002398277.1 CDS yeeS NC_011745.1 2286260 2286706 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11053371; Product type pf : putative factor; putative DNA repair protein; CP4-44 prophage 2286260..2286706 Escherichia coli ED1a 7143290 YP_002398278.1 CDS yeeT NC_011745.1 2286769 2286990 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2286769..2286990 Escherichia coli ED1a 7139385 YP_002398279.1 CDS yeeU NC_011745.1 2287064 2287432 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594833; Product type h : extrachromosomal origin; CP4-44 prophage YeeV-YeeU toxin-antitoxin system toxin 2287064..2287432 Escherichia coli ED1a 7139390 YP_002398280.1 CDS yoeF NC_011745.1 2288527 2288883 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2288527..2288883 Escherichia coli ED1a 7139400 YP_002398281.1 CDS yeeX NC_011745.1 2288984 2289379 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2288984..2289379) Escherichia coli ED1a 7140266 YP_002398282.1 CDS yeeA NC_011745.1 2289485 2290543 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(2289485..2290543) Escherichia coli ED1a 7139410 YP_002398283.1 CDS sbmC NC_011745.1 2290742 2291215 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11850398, 9442027, 8709849; Product type r : regulator; DNA gyrase inhibitor complement(2290742..2291215) Escherichia coli ED1a 7140562 YP_002398284.1 CDS dacD NC_011745.1 2291334 2292500 R removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; penicillin-binding protein 6B; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase complement(2291334..2292500) Escherichia coli ED1a 7141375 YP_002398285.1 CDS sbcB NC_011745.1 2292709 2294136 D Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates; exonuclease I 2292709..2294136 Escherichia coli ED1a 7143055 YP_002398286.1 CDS yeeD NC_011745.1 2294179 2294406 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2294179..2294406) Escherichia coli ED1a 7141371 YP_002398287.1 CDS yeeE NC_011745.1 2294420 2295478 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(2294420..2295478) Escherichia coli ED1a 7140563 YP_002398288.1 CDS yeeF NC_011745.1 2295657 2297015 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative amino-acid/amine transporter complement(2295657..2297015) Escherichia coli ED1a 7140564 YP_002398289.1 CDS yeeY NC_011745.1 2297282 2298211 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(2297282..2298211) Escherichia coli ED1a 7140565 YP_002398290.1 CDS yeeZ NC_011745.1 2298257 2299081 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative epimerase, with NAD(P)-binding Rossmann-fold domain complement(2298257..2299081) Escherichia coli ED1a 7139411 YP_002398292.1 CDS hisG NC_011745.1 2299703 2300602 D long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase 2299703..2300602 Escherichia coli ED1a 7139896 YP_002398293.1 CDS hisD NC_011745.1 2300608 2301912 D catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 2300608..2301912 Escherichia coli ED1a 7139892 YP_002398294.1 CDS hisC NC_011745.1 2301909 2302979 D catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 2301909..2302979 Escherichia coli ED1a 7139890 YP_002398295.1 CDS hisB NC_011745.1 2302979 2304046 D catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate; imidazole glycerol-phosphate dehydratase/histidinol phosphatase 2302979..2304046 Escherichia coli ED1a 7139889 YP_002398296.1 CDS hisH NC_011745.1 2304046 2304636 D with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 2304046..2304636 Escherichia coli ED1a 7139888 YP_002398297.1 CDS hisA NC_011745.1 2304636 2305373 D catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 2304636..2305373 Escherichia coli ED1a 7139893 YP_002398298.1 CDS hisF NC_011745.1 2305355 2306131 D catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 2305355..2306131 Escherichia coli ED1a 7139887 YP_002398299.1 CDS hisI NC_011745.1 2306125 2306736 D catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis; bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein 2306125..2306736 Escherichia coli ED1a 7139891 YP_002398300.1 CDS cld NC_011745.1 2306833 2307867 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98241528; Product type r : regulator; regulator of length of O-antigen component of lipopolysaccharide chains complement(2306833..2307867) Escherichia coli ED1a 7139894 YP_002398301.1 CDS ugd NC_011745.1 2307957 2309123 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9150218, 96326333; Product type e : enzyme; UDP-glucose 6-dehydrogenase complement(2307957..2309123) Escherichia coli ED1a 7139370 YP_002398302.1 CDS gnd NC_011745.1 2309371 2310777 R catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase complement(2309371..2310777) Escherichia coli ED1a 7140868 YP_002398303.1 CDS wbdN NC_011745.1 2311026 2311832 R Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Glycosyltransferase complement(2311026..2311832) Escherichia coli ED1a 7142997 YP_002398304.1 CDS ECED1_2380 NC_011745.1 2311811 2312857 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glycosyltransferase WbdM complement(2311811..2312857) Escherichia coli ED1a 7139177 YP_002398305.1 CDS ECED1_2381 NC_011745.1 2312902 2313624 R Evidence 5 : No homology to any previously reported sequences; putative glycosyltransferase complement(2312902..2313624) Escherichia coli ED1a 7143291 YP_002398306.1 CDS ECED1_2382 NC_011745.1 2315130 2315936 R Evidence 5 : No homology to any previously reported sequences; putative glycosyltransferase complement(2315130..2315936) Escherichia coli ED1a 7143292 YP_002398307.1 CDS ECED1_2383 NC_011745.1 2315933 2317105 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative CDP-glycerol:poly(Glycerophosphate) glycerophosphotransferase complement(2315933..2317105) Escherichia coli ED1a 7143293 YP_002398308.1 CDS ECED1_2384 NC_011745.1 2317089 2318390 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2317089..2318390) Escherichia coli ED1a 7143294 YP_002398309.1 CDS tagD NC_011745.1 2318463 2318858 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11882717, 1906926, 8393871, 9182537, 11487587, 10508782; Product type e : enzyme; glycerol-3-phosphate cytidylyltransferase complement(2318463..2318858) Escherichia coli ED1a 7143295 YP_002398310.1 CDS ECED1_2386 NC_011745.1 2319224 2320261 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89274199, 92253563, 92338916, 3022232, 6301942, 8564363, 8611559, 893113; Product type e : enzyme; UDP-glucose 4-epimerase complement(2319224..2320261) Escherichia coli ED1a 7141505 YP_002398311.1 CDS galF NC_011745.1 2320893 2321786 R together with GalU subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; UTP--glucose-1-phosphate uridylyltransferase subunit GalF complement(2320893..2321786) Escherichia coli ED1a 7143296 YP_002398312.1 CDS gne NC_011745.1 2322029 2323024 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11976290; Product type e : enzyme; UDP-N-acetylglucosamine 4-epimerase (UDP-GlcNAc 4-epimerase) complement(2322029..2323024) Escherichia coli ED1a 7143149 YP_002398313.1 CDS wcaM NC_011745.1 2323182 2324576 R WcaM from Salmonella enterica is essential for biofilm formation on HEp-2 cells and chicken intestinal tissue but not on a plastic surface; may be involved in the biosynthesis of colanic acid; putative colanic acid biosynthesis protein complement(2323182..2324576) Escherichia coli ED1a 7142998 YP_002398314.1 CDS wcaL NC_011745.1 2324587 2325807 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96326333; Product type pe : putative enzyme; putative glycosyl transferase complement(2324587..2325807) Escherichia coli ED1a 7139188 YP_002398315.1 CDS wcaK NC_011745.1 2325804 2327084 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96326333, 8759852, 11004393; Product type pe : putative enzyme; putative pyruvyl transferase complement(2325804..2327084) Escherichia coli ED1a 7139187 YP_002398316.1 CDS wzxC NC_011745.1 2327456 2328934 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96326333, 8759852; Product type pt : putative transporter; colanic acid exporter complement(2327456..2328934) Escherichia coli ED1a 7139186 YP_002398317.1 CDS wcaJ NC_011745.1 2328936 2330330 R WcaJ; glucose-1-phosphate transferase responsible for the addition of the first glucose-1-phosphate from UDP-glucose to the lipid carrier undecaprenyl phosphate in the biosynthesis of colanic acid; putative UDP-glucose lipid carrier transferase complement(2328936..2330330) Escherichia coli ED1a 7139193 YP_002398318.1 CDS cpsG NC_011745.1 2330385 2331755 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93106949, 96326333, 7815923, 8759852; Product type e : enzyme; phosphomannomutase complement(2330385..2331755) Escherichia coli ED1a 7139185 YP_002398319.1 CDS cpsB NC_011745.1 2332036 2333472 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82100097, 85006781, 92048476, 93122523, 96326333, 7815923, 8759852; Product type e : enzyme; mannose-1-phosphate guanyltransferase complement(2332036..2333472) Escherichia coli ED1a 7142044 YP_002398320.1 CDS wcaI NC_011745.1 2333475 2334698 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15670885, 96326333; Product type pe : putative enzyme; putative glycosyl transferase complement(2333475..2334698) Escherichia coli ED1a 7142043 YP_002398321.1 CDS nudD NC_011745.1 2334695 2335174 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96326333, 10913267, 7592609, 7815923, 8759852; Product type e : enzyme; GDP-mannose mannosyl hydrolase complement(2334695..2335174) Escherichia coli ED1a 7139184 YP_002398322.1 CDS fcl NC_011745.1 2335177 2336142 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96326333, 98132401, 9862812, 7815923, 8759852, 9473059; Product type e : enzyme; bifunctional GDP-fucose synthetase: GDP-4-dehydro-6-deoxy-D-mannose epimerase and GDP-4-dehydro-6-L-deoxygalactose reductase complement(2335177..2336142) Escherichia coli ED1a 7139939 YP_002398323.1 CDS gmd NC_011745.1 2336145 2337266 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20139699, 97400210, 10673432, 7815923, 8759852, 9257704, 14299611; Product type e : enzyme; GDP-D-mannose dehydratase, NAD(P)-binding complement(2336145..2337266) Escherichia coli ED1a 7144135 YP_002398324.1 CDS wcaF NC_011745.1 2337293 2337841 R acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); putative colanic acid biosynthesis acetyltransferase WcaF complement(2337293..2337841) Escherichia coli ED1a 7142993 YP_002398325.1 CDS wcaE NC_011745.1 2337857 2338603 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11371548, 96326333, 8759852; Product type pe : putative enzyme; putative glycosyl transferase complement(2337857..2338603) Escherichia coli ED1a 7139183 YP_002398326.1 CDS wcaD NC_011745.1 2338614 2339831 R essential for colanic acid biosynthesis; colanic acid is an exopolysaccharide produced under stress conditions that confers acid and heat tolerance; putative colanic acid biosynthesis protein complement(2338614..2339831) Escherichia coli ED1a 7139182 YP_002398327.1 CDS wcaC NC_011745.1 2339806 2341023 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96326333; Product type pe : putative enzyme; putative glycosyl transferase complement(2339806..2341023) Escherichia coli ED1a 7139181 YP_002398328.1 CDS wcaB NC_011745.1 2341020 2341508 R acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); wcaB is induced in sessile bacteria and by osmotic shock, and repressed when grown in rich medium; putative colanic acid biosynthesis acetyltransferase WcaB complement(2341020..2341508) Escherichia coli ED1a 7139180 YP_002398329.1 CDS wcaA NC_011745.1 2341511 2342350 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96326333; Product type pe : putative enzyme; putative glycosyl transferase complement(2341511..2342350) Escherichia coli ED1a 7139179 YP_002398330.1 CDS wzc NC_011745.1 2342506 2344668 R Wzc; catalyzes the autophosphorylation on tyrosine residues which downregulates the biosynthesis of colonic acid (an extracellular polysaccharide); tyrosine kinase complement(2342506..2344668) Escherichia coli ED1a 7139178 YP_002398331.1 CDS wzb NC_011745.1 2344671 2345114 R Wzb shows phosphatase activity towards the autophosphorylated Wzc protein, which induces colanic acid biosynthesis; catalyzes the phosphorylation of UDP-glucose dehydrogenase, an enzyme involved in colanic acid biosynthesis; tyrosine phosphatase complement(2344671..2345114) Escherichia coli ED1a 7139192 YP_002398332.1 CDS wza NC_011745.1 2345120 2346259 R Evidence 2b : Function of strongly homologous gene; PubMedId : 15090537, 96326333, 8759852, 8763957; Product type lp : lipoprotein; capsular polysaccharide translocation lipoprotein complement(2345120..2346259) Escherichia coli ED1a 7139191 YP_002398333.1 CDS yegH NC_011745.1 2346918 2348501 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; fused putative membrane protein ; putative membrane protein 2346918..2348501 Escherichia coli ED1a 7139190 YP_002398334.1 CDS asmA NC_011745.1 2348775 2350628 R YegA; inner membrane protein involved in the assembly of outer membrane proteins (OMPs); asmA-null mutants show low lipopolysaccharide (LPS) levels, suggesting a role in LPS biogenesis and/or in restricting outer membrane fluidity, resulting on altered assembly of OMPs; putative assembly protein complement(2348775..2350628) Escherichia coli ED1a 7139415 YP_002398335.1 CDS dcd NC_011745.1 2350650 2351231 R Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase complement(2350650..2351231) Escherichia coli ED1a 7142644 YP_002398336.1 CDS udk NC_011745.1 2351323 2351964 R functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase complement(2351323..2351964) Escherichia coli ED1a 7143068 YP_002398337.1 CDS yegE NC_011745.1 2352282 2355599 D contains a MASE1 (Membrane-Associated Sensor) domain; potentially involved in signal transduction; putative sensor protein 2352282..2355599 Escherichia coli ED1a 7140866 YP_002398338.1 CDS alkA NC_011745.1 2355717 2356565 R inducible, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine; 3-methyl-adenine DNA glycosylase II complement(2355717..2356565) Escherichia coli ED1a 7139414 YP_002398339.1 CDS yegD NC_011745.1 2356699 2358051 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 6094528, 7940673, 7984428; Product type pf : putative factor; putative chaperone 2356699..2358051 Escherichia coli ED1a 7143688 YP_002398340.1 CDS yegI NC_011745.1 2358064 2360010 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2358064..2360010) Escherichia coli ED1a 7139413 YP_002398341.1 CDS yegJ NC_011745.1 2360210 2360671 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2360210..2360671 Escherichia coli ED1a 7139416 YP_002398342.1 CDS yegK NC_011745.1 2360736 2361497 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2360736..2361497) Escherichia coli ED1a 7139417 YP_002398343.1 CDS yegL NC_011745.1 2361494 2362153 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2361494..2362153) Escherichia coli ED1a 7139418 YP_002398344.1 CDS mdtA NC_011745.1 2363041 2364288 D Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtA 2363041..2364288 Escherichia coli ED1a 7140156 YP_002398345.1 CDS mdtB NC_011745.1 2364288 2367410 D Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtB 2364288..2367410 Escherichia coli ED1a 7142227 YP_002398346.1 CDS mdtC NC_011745.1 2367411 2370488 D Part of a tripartite efflux system composed of MdtA, MdtB and MdtC; confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtC 2367411..2370488 Escherichia coli ED1a 7142228 YP_002398347.1 CDS mdtD NC_011745.1 2370489 2371904 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12107134, 21450803, 8282725; Product type t : transporter; multidrug efflux system protein MdtE 2370489..2371904 Escherichia coli ED1a 7142229 YP_002398348.1 CDS baeS NC_011745.1 2371901 2373304 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94110256, 8282725; Product type r : regulator; signal transduction histidine-protein kinase BaeS 2371901..2373304 Escherichia coli ED1a 7142230 YP_002398349.1 CDS baeR NC_011745.1 2373301 2374023 D response regulator in two-component regulatory system with BaeS; regulator of RNA synthesis, flagellar biosynthesis, chemotaxis and transport; DNA-binding transcriptional regulator BaeR 2373301..2374023 Escherichia coli ED1a 7140428 YP_002398350.1 CDS yegP NC_011745.1 2374203 2374535 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2374203..2374535 Escherichia coli ED1a 7140427 YP_002398351.1 CDS ECED1_2427 NC_011745.1 2374660 2375274 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2374660..2375274) Escherichia coli ED1a 7139420 YP_002398352.1 CDS ECED1_2428 NC_011745.1 2375326 2377473 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2375326..2377473) Escherichia coli ED1a 7143304 YP_002398353.1 CDS ECED1_2429 NC_011745.1 2377445 2378161 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2377445..2378161) Escherichia coli ED1a 7143305 YP_002398354.1 CDS ECED1_2430 NC_011745.1 2378161 2379375 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2378161..2379375) Escherichia coli ED1a 7143306 YP_002398355.1 CDS yegQ NC_011745.1 2379863 2381224 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative peptidase 2379863..2381224 Escherichia coli ED1a 7143307 YP_002398356.1 CDS ogrK NC_011745.1 2381497 2381715 R in E. coli K-12 this is in prophage P2 remnant; DNA-binding transcriptional regulator complement(2381497..2381715) Escherichia coli ED1a 7140157 YP_002398357.1 CDS GpD NC_011745.1 2381796 2382959 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 3458177; Product type h : extrachromosomal origin; phage late control gene D protein complement(2381796..2382959) Escherichia coli ED1a 7139965 YP_002398358.1 CDS GpU NC_011745.1 2382959 2383438 R Evidence 2b : Function of strongly homologous gene; PubMedId : 12426340; Product type h : extrachromosomal origin; tail assembly protein (GpU) complement(2382959..2383438) Escherichia coli ED1a 7143009 YP_002398359.1 CDS GpT NC_011745.1 2383453 2385900 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail fiber protein T complement(2383453..2385900) Escherichia coli ED1a 7143018 YP_002398360.1 CDS GpE NC_011745.1 2386045 2386320 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail protein E (GpE) complement(2386045..2386320) Escherichia coli ED1a 7143308 YP_002398361.1 CDS ECED1_2438 NC_011745.1 2386377 2386895 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; major tail sheath protein FII complement(2386377..2386895) Escherichia coli ED1a 7143010 YP_002398362.1 CDS ECED1_2439 NC_011745.1 2386908 2388098 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; major tail sheath protein FI complement(2386908..2388098) Escherichia coli ED1a 7143309 YP_002398363.1 CDS ECED1_2440 NC_011745.1 2388417 2388806 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2388417..2388806 Escherichia coli ED1a 7143310 YP_002398364.1 CDS ECED1_2441 NC_011745.1 2388829 2389515 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; site-specific recombinase, phage integrase family complement(2388829..2389515) Escherichia coli ED1a 7143311 YP_002398365.1 CDS ECED1_2442 NC_011745.1 2389520 2390362 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2389520..2390362) Escherichia coli ED1a 7143312 YP_002398366.1 CDS ECED1_2443 NC_011745.1 2390783 2391310 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage tail fiber assembly protein (GpG) complement(2390783..2391310) Escherichia coli ED1a 7143313 YP_002398367.1 CDS ECED1_2444 NC_011745.1 2391314 2393419 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative tail fiber protein (GpH) complement(2391314..2393419) Escherichia coli ED1a 7143314 YP_002398368.1 CDS ECED1_2445 NC_011745.1 2393430 2393960 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail protein I (GpI) complement(2393430..2393960) Escherichia coli ED1a 7143315 YP_002398369.1 CDS ECED1_2446 NC_011745.1 2393953 2394861 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Baseplate assembly protein GpJ complement(2393953..2394861) Escherichia coli ED1a 7143316 YP_002398370.1 CDS ECED1_2447 NC_011745.1 2394866 2395213 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Baseplate assembly protein GpW complement(2394866..2395213) Escherichia coli ED1a 7143317 YP_002398371.1 CDS ECED1_2448 NC_011745.1 2395210 2395863 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Baseplate assembly protein GpV complement(2395210..2395863) Escherichia coli ED1a 7143318 YP_002398372.1 CDS ECED1_2449 NC_011745.1 2395929 2396642 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2395929..2396642 Escherichia coli ED1a 7143319 YP_002398373.1 CDS yegR NC_011745.1 2397082 2397399 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2397082..2397399) Escherichia coli ED1a 7143320 YP_002398374.1 CDS insB NC_011745.1 2398536 2399039 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' complement(2398536..2399039) Escherichia coli ED1a 7139423 YP_002398375.1 CDS insA NC_011745.1 2398958 2399233 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA complement(2398958..2399233) Escherichia coli ED1a 7141144 YP_002398376.1 CDS yegU NC_011745.1 2399313 2400317 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative (phospho)hydrolase 2399313..2400317 Escherichia coli ED1a 7141122 YP_002398377.1 CDS yegV NC_011745.1 2400314 2401279 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative kinase 2400314..2401279 Escherichia coli ED1a 7139424 YP_002398378.1 CDS yegW NC_011745.1 2401253 2401999 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(2401253..2401999) Escherichia coli ED1a 7139425 YP_002398379.1 CDS yegX NC_011745.1 2402051 2402869 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-bound hydrolase complement(2402051..2402869) Escherichia coli ED1a 7139426 YP_002398380.1 CDS thiD NC_011745.1 2402934 2403734 R catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase complement(2402934..2403734) Escherichia coli ED1a 7139427 YP_002398381.1 CDS thiM NC_011745.1 2403731 2404519 R catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase complement(2403731..2404519) Escherichia coli ED1a 7141540 YP_002398382.1 CDS yohL NC_011745.1 2404742 2405014 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2404742..2405014) Escherichia coli ED1a 7140756 YP_002398383.1 CDS rncA NC_011745.1 2405135 2405959 D membrane protein conferring nickel and cobalt resistance; nickel/cobalt efflux protein RcnA 2405135..2405959 Escherichia coli ED1a 7140273 YP_002398384.1 CDS yohN NC_011745.1 2405998 2406516 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2405998..2406516 Escherichia coli ED1a 7141433 YP_002398385.1 CDS yehA NC_011745.1 2406598 2407632 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative exported fimbrial-like adhesin protein complement(2406598..2407632) Escherichia coli ED1a 7140274 YP_002398386.1 CDS yehB NC_011745.1 2407648 2410128 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(2407648..2410128) Escherichia coli ED1a 7139428 YP_002398387.1 CDS yehC NC_011745.1 2410144 2410818 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative membrane-associated pilin chaperone complement(2410144..2410818) Escherichia coli ED1a 7139429 YP_002398388.1 CDS yehD NC_011745.1 2410899 2411441 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin protein complement(2410899..2411441) Escherichia coli ED1a 7139430 YP_002398389.1 CDS yehE NC_011745.1 2411735 2412016 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2411735..2412016) Escherichia coli ED1a 7139431 YP_002398390.1 CDS mrp NC_011745.1 2412279 2413388 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91080852, 15601724, 2259334; Product type t : transporter; putative ATPase complement(2412279..2413388) Escherichia coli ED1a 7139432 YP_002398391.1 CDS metG NC_011745.1 2413520 2415553 D methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 2413520..2415553 Escherichia coli ED1a 7139029 YP_002398392.1 CDS ECED1_2471 NC_011745.1 2415694 2419482 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2156810; Product type pr : putative regulator; putative Molybdate metabolism regulator (molR) 2415694..2419482 Escherichia coli ED1a 7142253 YP_002398393.1 CDS yehI NC_011745.1 2419492 2423124 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2419492..2423124 Escherichia coli ED1a 7143321 YP_002398394.1 CDS yehK NC_011745.1 2423185 2423505 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2423185..2423505 Escherichia coli ED1a 7139433 YP_002398395.1 CDS yehL NC_011745.1 2424081 2425169 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16428726; Product type pf : putative factor; putative ABC superfamily protein 2424081..2425169 Escherichia coli ED1a 7139434 YP_002398396.1 CDS yehM NC_011745.1 2425180 2427459 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2425180..2427459 Escherichia coli ED1a 7139435 YP_002398397.1 CDS yehP NC_011745.1 2427452 2428588 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2427452..2428588 Escherichia coli ED1a 7139436 YP_002398398.1 CDS yehQ NC_011745.1 2428585 2430588 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2428585..2430588 Escherichia coli ED1a 7139437 YP_002398399.1 CDS yehR NC_011745.1 2430713 2431174 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type lp : lipoprotein; hypothetical protein 2430713..2431174 Escherichia coli ED1a 7139438 YP_002398400.1 CDS yehS NC_011745.1 2431215 2431685 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2431215..2431685) Escherichia coli ED1a 7139439 YP_002398401.1 CDS yehT NC_011745.1 2431732 2432451 R unknown function; when overproduced it confers drug-resistance; putative two-component response-regulatory protein YehT complement(2431732..2432451) Escherichia coli ED1a 7139440 YP_002398402.1 CDS yehU NC_011745.1 2432448 2434133 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15522865, 15322361; Product type rc : receptor; sensory kinase in two-component system with YehT complement(2432448..2434133) Escherichia coli ED1a 7139441 YP_002398403.1 CDS ECED1_2483 NC_011745.1 2434648 2434896 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative damage-inducible protein dinI-like 2434648..2434896 Escherichia coli ED1a 7139442 YP_002398404.1 CDS eaaA NC_011745.1 2435263 2439288 R Evidence 2b : Function of strongly homologous gene; PubMedId : 10722621, 17220264; Product type h : extrachromosomal origin; serine protease autotransporter complement(2435263..2439288) Escherichia coli ED1a 7143322 YP_002398405.1 CDS ECED1_2485 NC_011745.1 2439562 2440032 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10722621; hypothetical protein complement(2439562..2440032) Escherichia coli ED1a 7139762 YP_002398406.1 CDS eibA NC_011745.1 2440120 2441310 R Evidence 2b : Function of strongly homologous gene; PubMedId : 10722621; Product type h : extrachromosomal origin; Immunoglobulin-binding protein from prophage P-EibA complement(2440120..2441310) Escherichia coli ED1a 7143323 YP_002398407.1 CDS ECED1_2487 NC_011745.1 2441992 2442648 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10722621; Product type h : extrachromosomal origin; hypothetical protein complement(2441992..2442648) Escherichia coli ED1a 7139779 YP_002398408.1 CDS ECED1_2488 NC_011745.1 2442590 2444071 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative tail fiber protein from prophage complement(2442590..2444071) Escherichia coli ED1a 7143324 YP_002398409.1 CDS J NC_011745.1 2444256 2447786 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Host specificity protein J (tail component) from prophage complement(2444256..2447786) Escherichia coli ED1a 7143325 YP_002398410.1 CDS ECED1_2490 NC_011745.1 2448026 2448706 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail assembly protein I complement(2448026..2448706) Escherichia coli ED1a 7142482 YP_002398411.1 CDS ECED1_2491 NC_011745.1 2448604 2449341 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail fiber component K complement(2448604..2449341) Escherichia coli ED1a 7143326 YP_002398412.1 CDS ECED1_2492 NC_011745.1 2449396 2450310 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative antirepressor protein in prophage complement(2449396..2450310) Escherichia coli ED1a 7143327 YP_002398413.1 CDS ECED1_2494 NC_011745.1 2450600 2450872 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7999761, 10426954; Product type pr : putative regulator; putative regulatory protein (mnt like) 2450600..2450872 Escherichia coli ED1a 7143329 YP_002398414.1 CDS ECED1_2495 NC_011745.1 2450872 2451408 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative Clp protease 2450872..2451408 Escherichia coli ED1a 7143330 YP_002398415.1 CDS ECED1_2496 NC_011745.1 2451465 2452217 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein L complement(2451465..2452217) Escherichia coli ED1a 7143331 YP_002398416.1 CDS ECED1_2497 NC_011745.1 2452360 2453523 R Evidence 2b : Function of strongly homologous gene; Product type t : transporter; outer membrane porin protein from phage origin complement(2452360..2453523) Escherichia coli ED1a 7143332 YP_002398417.1 CDS ECED1_2498 NC_011745.1 2453730 2454071 R Evidence 2b : Function of strongly homologous gene; PubMedId : 11686382, 11282477, 9562894, 8878031; Product type f : factor; minor tail protein M complement(2453730..2454071) Escherichia coli ED1a 7143333 YP_002398418.1 CDS ECED1_2499 NC_011745.1 2454064 2457306 R Evidence 2b : Function of strongly homologous gene; Product type f : factor; tail component measure protein in prophage complement(2454064..2457306) Escherichia coli ED1a 7143334 YP_002398419.1 CDS ECED1_2500 NC_011745.1 2457370 2457783 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2457370..2457783) Escherichia coli ED1a 7143335 YP_002398420.1 CDS ECED1_2501 NC_011745.1 2457847 2458128 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2457847..2458128) Escherichia coli ED1a 7143336 YP_002398421.1 CDS ECED1_2502 NC_011745.1 2458152 2458574 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative tail assembly protein in prophage complement(2458152..2458574) Escherichia coli ED1a 7143337 YP_002398422.1 CDS ECED1_2503 NC_011745.1 2458541 2459257 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative major tail subunit in prophage complement(2458541..2459257) Escherichia coli ED1a 7143338 YP_002398423.1 CDS ECED1_2504 NC_011745.1 2459324 2459668 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2459324..2459668) Escherichia coli ED1a 7143339 YP_002398424.1 CDS ECED1_2505 NC_011745.1 2459665 2460111 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative structural component HK97 gp of phage origin complement(2459665..2460111) Escherichia coli ED1a 7143340 YP_002398425.1 CDS ECED1_2506 NC_011745.1 2460108 2460458 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative head-tail adaptor in prophage complement(2460108..2460458) Escherichia coli ED1a 7143341 YP_002398426.1 CDS ECED1_2507 NC_011745.1 2460468 2460794 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2460468..2460794) Escherichia coli ED1a 7143342 YP_002398427.1 CDS ECED1_2508 NC_011745.1 2460791 2462014 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2460791..2462014) Escherichia coli ED1a 7143343 YP_002398428.1 CDS ECED1_2509 NC_011745.1 2462011 2463375 R Evidence 2b : Function of strongly homologous gene; Product type s : structure; phage portal protein complement(2462011..2463375) Escherichia coli ED1a 7143344 YP_002398429.1 CDS ECED1_2510 NC_011745.1 2463321 2463542 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2463321..2463542) Escherichia coli ED1a 7143345 YP_002398430.1 CDS ECED1_2511 NC_011745.1 2463587 2465524 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative major head protein/prohead protease in prophage complement(2463587..2465524) Escherichia coli ED1a 7143346 YP_002398431.1 CDS ECED1_2512 NC_011745.1 2465588 2467249 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative terminase large subunit from phage origin complement(2465588..2467249) Escherichia coli ED1a 7143347 YP_002398432.1 CDS ECED1_2513 NC_011745.1 2467246 2467809 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative terminase small subunit in prophage complement(2467246..2467809) Escherichia coli ED1a 7143348 YP_002398433.1 CDS ECED1_2514 NC_011745.1 2468099 2468464 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative endonuclease from phage origin complement(2468099..2468464) Escherichia coli ED1a 7143349 YP_002398434.1 CDS ECED1_2515 NC_011745.1 2468446 2468706 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2468446..2468706 Escherichia coli ED1a 7143350 YP_002398435.1 CDS ECED1_2516 NC_011745.1 2468838 2469179 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative tonB-like membrane protein from phage origin complement(2468838..2469179) Escherichia coli ED1a 7143351 YP_002398436.1 CDS ECED1_2517 NC_011745.1 2469100 2469453 R Evidence 6 : Doubtful CDS; Product type h : extrachromosomal origin; hypothetical protein complement(2469100..2469453) Escherichia coli ED1a 7143352 YP_002398437.1 CDS ECED1_2518 NC_011745.1 2469598 2469855 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2469598..2469855) Escherichia coli ED1a 7143353 YP_002398438.1 CDS ECED1_2519 NC_011745.1 2469852 2470418 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2469852..2470418) Escherichia coli ED1a 7142744 YP_002398439.1 CDS ECED1_2520 NC_011745.1 2470548 2470877 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2470548..2470877) Escherichia coli ED1a 7140649 YP_002398440.1 CDS ECED1_2521 NC_011745.1 2470852 2471082 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2470852..2471082) Escherichia coli ED1a 7140652 YP_002398441.1 CDS rz NC_011745.1 2471224 2471775 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Endopeptidase (Lysis protein) from bacteriophage origin complement(2471224..2471775) Escherichia coli ED1a 7140653 YP_002398442.1 CDS ECED1_2525 NC_011745.1 2471910 2472227 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2471910..2472227) Escherichia coli ED1a 7141361 YP_002398443.1 CDS ECED1_2526 NC_011745.1 2472136 2472831 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative antirepressor in prophage complement(2472136..2472831) Escherichia coli ED1a 7140654 YP_002398444.1 CDS ydfQ NC_011745.1 2473105 2473638 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-associated lysozyme; Qin prophage complement(2473105..2473638) Escherichia coli ED1a 7140655 YP_002398445.1 CDS ECED1_2528 NC_011745.1 2473700 2473939 D Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 2473700..2473939 Escherichia coli ED1a 7139268 YP_002398446.1 CDS ECED1_2529 NC_011745.1 2473872 2474402 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2473872..2474402) Escherichia coli ED1a 7140656 YP_002398447.1 CDS essD NC_011745.1 2474407 2474622 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage lysis protein S complement(2474407..2474622) Escherichia coli ED1a 7140657 YP_002398448.1 CDS ECED1_2531 NC_011745.1 2474698 2475141 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2474698..2475141) Escherichia coli ED1a 7139815 YP_002398449.1 CDS ECED1_2532 NC_011745.1 2475221 2475394 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2475221..2475394) Escherichia coli ED1a 7140658 YP_002398450.1 CDS ECED1_2533 NC_011745.1 2475348 2477345 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2475348..2477345) Escherichia coli ED1a 7140659 YP_002398451.1 CDS ECED1_2534 NC_011745.1 2478222 2478386 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2478222..2478386) Escherichia coli ED1a 7140660 YP_002398452.1 CDS ECED1_2535 NC_011745.1 2478383 2478886 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2478383..2478886) Escherichia coli ED1a 7140661 YP_002398453.1 CDS ECED1_2536 NC_011745.1 2479121 2479639 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage antitermination protein Q complement(2479121..2479639) Escherichia coli ED1a 7140621 YP_002398454.1 CDS ninG NC_011745.1 2479683 2480288 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Protein ninG from prophage complement(2479683..2480288) Escherichia coli ED1a 7140663 YP_002398455.1 CDS roi NC_011745.1 2480288 2481016 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; DNA-binding protein from phage origin complement(2480288..2481016) Escherichia coli ED1a 7140392 YP_002398456.1 CDS ant NC_011745.1 2481085 2481798 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Ant antirepressor protein from prophage complement(2481085..2481798) Escherichia coli ED1a 7141446 YP_002398457.1 CDS ECED1_2540 NC_011745.1 2481738 2481971 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2481738..2481971) Escherichia coli ED1a 7142586 YP_002398458.1 CDS ECED1_2541 NC_011745.1 2482256 2482810 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative DNA N-6-adenine-methyltransferase from phage origin complement(2482256..2482810) Escherichia coli ED1a 7140664 YP_002398459.1 CDS ECED1_2542 NC_011745.1 2482780 2483328 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative prophage protein ninB complement(2482780..2483328) Escherichia coli ED1a 7140665 YP_002398460.1 CDS ECED1_2543 NC_011745.1 2483183 2483425 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2483183..2483425) Escherichia coli ED1a 7140666 YP_002398461.1 CDS ECED1_2544 NC_011745.1 2483430 2483645 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2483430..2483645) Escherichia coli ED1a 7140667 YP_002398462.1 CDS ECED1_2545 NC_011745.1 2483731 2484021 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Ren protein from phage origin complement(2483731..2484021) Escherichia coli ED1a 7140668 YP_002398463.1 CDS ECED1_2546 NC_011745.1 2484018 2484719 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative replication protein P of bacteriophage complement(2484018..2484719) Escherichia coli ED1a 7140669 YP_002398464.1 CDS O NC_011745.1 2484716 2485654 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; replication protein from bacteriophage origin complement(2484716..2485654) Escherichia coli ED1a 7140670 YP_002398465.1 CDS ECED1_2548 NC_011745.1 2485687 2485986 R Evidence 2b : Function of strongly homologous gene; PubMedId : 375198; Product type h : extrachromosomal origin; regulatory protein CII from phage origin complement(2485687..2485986) Escherichia coli ED1a 7139980 YP_002398466.1 CDS ECED1_2549 NC_011745.1 2486126 2486383 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative repressor protein from phage complement(2486126..2486383) Escherichia coli ED1a 7140671 YP_002398467.1 CDS cI NC_011745.1 2486453 2487100 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Repressor protein CI from phage 2486453..2487100 Escherichia coli ED1a 7140672 YP_002398468.1 CDS ECED1_2551 NC_011745.1 2487097 2487585 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2487097..2487585 Escherichia coli ED1a 7139354 YP_002398469.1 CDS ECED1_2552 NC_011745.1 2487582 2488202 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2487582..2488202 Escherichia coli ED1a 7140673 YP_002398470.1 CDS ECED1_2553 NC_011745.1 2488636 2488980 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9501914; Product type h : extrachromosomal origin; N protein (anti-termination protein) 2488636..2488980 Escherichia coli ED1a 7140674 YP_002398471.1 CDS ECED1_2554 NC_011745.1 2488982 2489665 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2488982..2489665 Escherichia coli ED1a 7140675 YP_002398472.1 CDS kil NC_011745.1 2489897 2490166 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Host killing protein from bacteriophage origin 2489897..2490166 Escherichia coli ED1a 7140676 YP_002398473.1 CDS ECED1_2556 NC_011745.1 2490240 2490536 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative host-nuclease inhibitor protein Gam of bacteriophage 2490240..2490536 Escherichia coli ED1a 7142513 YP_002398474.1 CDS ECED1_2557 NC_011745.1 2490542 2491327 D Evidence 2b : Function of strongly homologous gene; PubMedId : 6458018, 6221115; Product type h : extrachromosomal origin; Recombination protein bet from phage origin 2490542..2491327 Escherichia coli ED1a 7140677 YP_002398475.1 CDS ECED1_2558 NC_011745.1 2491324 2492004 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; exonuclease from phage origin 2491324..2492004 Escherichia coli ED1a 7140678 YP_002398476.1 CDS ECED1_2559 NC_011745.1 2492156 2492908 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2492156..2492908 Escherichia coli ED1a 7140679 YP_002398477.1 CDS ECED1_2560 NC_011745.1 2492778 2493131 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2492778..2493131 Escherichia coli ED1a 7140680 YP_002398478.1 CDS ECED1_2561 NC_011745.1 2493230 2493451 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2493230..2493451 Escherichia coli ED1a 7140681 YP_002398479.1 CDS ECED1_2562 NC_011745.1 2493448 2494143 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2493448..2494143 Escherichia coli ED1a 7140682 YP_002398480.1 CDS ECED1_2563 NC_011745.1 2494064 2494336 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2494064..2494336 Escherichia coli ED1a 7140683 YP_002398481.1 CDS ECED1_2564 NC_011745.1 2494339 2494617 D Evidence 7 : Gene remnant; Product type h : extrachromosomal origin; hypothetical protein 2494339..2494617 Escherichia coli ED1a 7140684 YP_002398482.1 CDS ECED1_2565 NC_011745.1 2494457 2494810 D Evidence 7 : Gene remnant; Product type h : extrachromosomal origin; hypothetical protein 2494457..2494810 Escherichia coli ED1a 7140685 YP_002398483.1 CDS ECED1_2566 NC_011745.1 2494838 2495173 D Evidence 7 : Gene remnant; Product type h : extrachromosomal origin; hypothetical protein 2494838..2495173 Escherichia coli ED1a 7140686 YP_002398484.1 CDS ECED1_2567 NC_011745.1 2495222 2495500 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2495222..2495500 Escherichia coli ED1a 7140687 YP_002398485.1 CDS xis NC_011745.1 2495657 2495911 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Excisionase 2495657..2495911 Escherichia coli ED1a 7140688 YP_002398486.1 CDS int NC_011745.1 2495945 2497231 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; phage integrase 2495945..2497231 Escherichia coli ED1a 7139208 YP_002398487.1 CDS mlrA NC_011745.1 2497306 2497953 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11489123; Product type r : regulator; DNA-binding transcriptional regulator 2497306..2497953 Escherichia coli ED1a 7141179 YP_002398488.1 CDS yehW NC_011745.1 2498101 2498832 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter permease complement(2498101..2498832) Escherichia coli ED1a 7138989 YP_002398489.1 CDS yehX NC_011745.1 2498837 2499763 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATP-binding protein transporter complement(2498837..2499763) Escherichia coli ED1a 7139443 YP_002398490.1 CDS yehY NC_011745.1 2499756 2500913 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter permease complement(2499756..2500913) Escherichia coli ED1a 7139444 YP_002398491.1 CDS yehZ NC_011745.1 2500920 2501837 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15251200; Product type pt : putative transporter; putative ABC transporter periplasmic-binding protein complement(2500920..2501837) Escherichia coli ED1a 7139445 YP_002398492.1 CDS bglX NC_011745.1 2502027 2504324 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96303506; Product type e : enzyme; beta-D-glucoside glucohydrolase complement(2502027..2504324) Escherichia coli ED1a 7139446 YP_002398493.1 CDS dld NC_011745.1 2504520 2506235 D component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent; D-lactate dehydrogenase 2504520..2506235 Escherichia coli ED1a 7140449 YP_002398494.1 CDS pbpG NC_011745.1 2506274 2507206 R specifically hydrolyze the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi; Penicillin-binding protein 7; D-alanyl-D-alanine endopeptidase complement(2506274..2507206) Escherichia coli ED1a 7140497 YP_002398495.1 CDS yohC NC_011745.1 2507380 2507967 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(2507380..2507967) Escherichia coli ED1a 7144047 YP_002398496.1 CDS yohD NC_011745.1 2508137 2508715 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2508137..2508715 Escherichia coli ED1a 7140267 YP_002398497.1 CDS yohF NC_011745.1 2508835 2509596 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; acetoin dehydrogenase complement(2508835..2509596) Escherichia coli ED1a 7140268 YP_002398498.1 CDS yohG NC_011745.1 2509649 2510737 R may be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug resistance outer membrane protein MdtQ complement(2509649..2510737) Escherichia coli ED1a 7140269 YP_002398499.1 CDS ECED1_2585 NC_011745.1 2511639 2512706 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transposase, IS110 family 2511639..2512706 Escherichia coli ED1a 7140270 YP_002398500.1 CDS ECED1_2586 NC_011745.1 2512915 2513097 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2512915..2513097 Escherichia coli ED1a 7140689 YP_002398501.1 CDS dusC NC_011745.1 2513166 2514182 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 22095566; Product type e : enzyme; tRNA-dihydrouridine synthase C complement(2513166..2514182) Escherichia coli ED1a 7140690 YP_002398502.1 CDS yohJ NC_011745.1 2514355 2514753 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2514355..2514753 Escherichia coli ED1a 7140533 YP_002398503.1 CDS yohK NC_011745.1 2514750 2515445 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2514750..2515445 Escherichia coli ED1a 7140271 YP_002398504.1 CDS cdd NC_011745.1 2515575 2516459 D Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 2515575..2516459 Escherichia coli ED1a 7140272 YP_002398505.1 CDS sanA NC_011745.1 2516609 2517328 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 96125233, 1567863, 8550448; hypothetical protein 2516609..2517328 Escherichia coli ED1a 7139324 YP_002398506.1 CDS yeiS NC_011745.1 2517331 2517570 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2517331..2517570 Escherichia coli ED1a 7141363 YP_002398507.1 CDS yeiT NC_011745.1 2517764 2519002 D function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain; putative oxidoreductase 2517764..2519002 Escherichia coli ED1a 7139459 YP_002398508.1 CDS yeiA NC_011745.1 2518996 2520231 D catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines; dihydropyrimidine dehydrogenase 2518996..2520231 Escherichia coli ED1a 7139460 YP_002398509.1 CDS mglC NC_011745.1 2520474 2521484 R ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex; beta-methylgalactoside transporter inner membrane component complement(2520474..2521484) Escherichia coli ED1a 7139447 YP_002398510.1 CDS mglA NC_011745.1 2521500 2523020 R with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains; galactose/methyl galaxtoside transporter ATP-binding protein complement(2521500..2523020) Escherichia coli ED1a 7142266 YP_002398511.1 CDS mglB NC_011745.1 2523081 2524079 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87286407, 92049246, 1719366, 3057628, 3302609, 3600760, 6340108, 6885805, 7012152, 9298646; Product type t : transporter; methyl-galactoside ABC transporter subunit periplasmic-binding protein complement(2523081..2524079) Escherichia coli ED1a 7142264 YP_002398512.1 CDS galS NC_011745.1 2524359 2525399 R negative regulator of the mglBAC operon for galactose utilization; DNA-binding transcriptional regulator GalS complement(2524359..2525399) Escherichia coli ED1a 7142265 YP_002398513.1 CDS ECED1_2599 NC_011745.1 2525389 2525592 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2525389..2525592 Escherichia coli ED1a 7143154 YP_002398514.1 CDS yeiB NC_011745.1 2525541 2526698 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(2525541..2526698) Escherichia coli ED1a 7140691 YP_002398515.1 CDS folE NC_011745.1 2526715 2527383 R involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I complement(2526715..2527383) Escherichia coli ED1a 7139448 YP_002398516.1 CDS ECED1_2602 NC_011745.1 2527537 2527713 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2527537..2527713 Escherichia coli ED1a 7142159 YP_002398517.1 CDS frmC NC_011745.1 2527641 2528477 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16567800; Product type e : enzyme; S-formylglutathione hydrolase 2527641..2528477 Escherichia coli ED1a 7140692 YP_002398518.1 CDS cirA NC_011745.1 2528509 2530434 R Cir; FeuA; CirA; receptor protein for siderophores (colicin IA, IB and V) and microcins (E492, H47, and M); TonB-dependent; able to transport monomers, dimer, and linear trimers of 2,3-dihydorxybenzoylserine; outer membrane protein; colicin I receptor complement(2528509..2530434) Escherichia coli ED1a 7142173 YP_002398519.1 CDS lysP NC_011745.1 2530792 2532261 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92250419, 94252996, 1315732, 7551055; Product type t : transporter; lysine transporter complement(2530792..2532261) Escherichia coli ED1a 7139358 YP_002398520.1 CDS yeiE NC_011745.1 2532466 2533347 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12400704, 1315732; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(2532466..2533347) Escherichia coli ED1a 7141933 YP_002398521.1 CDS yeiH NC_011745.1 2533446 2534495 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2533446..2534495 Escherichia coli ED1a 7139450 YP_002398522.1 CDS nfo NC_011745.1 2534569 2535426 D Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues; endonuclease IV 2534569..2535426 Escherichia coli ED1a 7139451 YP_002398523.1 CDS yeiI NC_011745.1 2535430 2536518 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 2535430..2536518 Escherichia coli ED1a 7140377 YP_002398524.1 CDS rihB NC_011745.1 2536786 2537727 R Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively; ribonucleoside hydrolase 2 complement(2536786..2537727) Escherichia coli ED1a 7139452 YP_002398525.1 CDS yeiL NC_011745.1 2537896 2538555 D activator of nucleoside metabolism; DNA-binding transcriptional activator YeiL 2537896..2538555 Escherichia coli ED1a 7141414 YP_002398526.1 CDS yeiM NC_011745.1 2538622 2539872 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sodium/proton nucleoside transporter complement(2538622..2539872) Escherichia coli ED1a 7139453 YP_002398527.1 CDS yeiN NC_011745.1 2539966 2540904 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2539966..2540904) Escherichia coli ED1a 7139454 YP_002398528.1 CDS yeiC NC_011745.1 2540892 2541947 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein complement(2540892..2541947) Escherichia coli ED1a 7139455 YP_002398529.1 CDS fruA NC_011745.1 2542289 2543980 R phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system fructose-specific transporter subunits IIBC complement(2542289..2543980) Escherichia coli ED1a 7139449 YP_002398530.1 CDS fruK NC_011745.1 2543997 2544935 R converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers; 1-phosphofructokinase complement(2543997..2544935) Escherichia coli ED1a 7142177 YP_002398531.1 CDS fruB NC_011745.1 2544935 2546065 R phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr; bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein complement(2544935..2546065) Escherichia coli ED1a 7142179 YP_002398532.1 CDS ECED1_2620 NC_011745.1 2547611 2547997 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2547611..2547997) Escherichia coli ED1a 7141402 YP_002398533.1 CDS yeiP NC_011745.1 2548020 2548592 D Stimulates the peptidyltransferase activity of the 70S ribosome and enhances dipeptide synthesis with N-formylmethionyl-tRNA and puromycin in vitro, suggesting its involvement in the formation of the first peptide bond of a protein; elongation factor P 2548020..2548592 Escherichia coli ED1a 7140693 YP_002398534.1 CDS yeiQ NC_011745.1 2548815 2550281 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sugar dehydrogenase, NAD-dependent 2548815..2550281 Escherichia coli ED1a 7139456 YP_002398535.1 CDS yeiR NC_011745.1 2550399 2551385 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 2550399..2551385 Escherichia coli ED1a 7139457 YP_002398536.1 CDS yeiU NC_011745.1 2551424 2552137 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15778224; Product type e : enzyme; undecaprenyl pyrophosphate phosphatase 2551424..2552137 Escherichia coli ED1a 7139458 YP_002398537.1 CDS spr NC_011745.1 2552549 2553115 D by similarity, Spr seems to have peptidase activity; involved in thermoresistance; putative outer membrane lipoprotein 2552549..2553115 Escherichia coli ED1a 7139461 YP_002398538.1 CDS rtn NC_011745.1 2553296 2554852 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2553296..2554852 Escherichia coli ED1a 7143833 YP_002398539.1 CDS yejB NC_011745.1 2556749 2557843 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative oligopeptide transporter subunit; permease component of ABC superfamily 2556749..2557843 Escherichia coli ED1a 7139463 YP_002398540.1 CDS yejE NC_011745.1 2557843 2558757 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative oligopeptide ABC transporter permease 2557843..2558757 Escherichia coli ED1a 7139464 YP_002398541.1 CDS yejF NC_011745.1 2558870 2560459 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative oligopeptide ABC transporter subunits ATP-binding protein 2558870..2560459 Escherichia coli ED1a 7143791 YP_002398542.1 CDS yejG NC_011745.1 2560463 2560807 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2560463..2560807) Escherichia coli ED1a 7143953 YP_002398543.1 CDS bcr NC_011745.1 2561140 2562330 R Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance; bicyclomycin/multidrug efflux system complement(2561140..2562330) Escherichia coli ED1a 7143954 YP_002398544.1 CDS rsuA NC_011745.1 2562358 2563053 R catalyzes the synthesis pseudouridine from uracil-516 in 16S ribosomal RNA; 16S rRNA pseudouridylate synthase A complement(2562358..2563053) Escherichia coli ED1a 7140434 YP_002398545.1 CDS yejH NC_011745.1 2563203 2564963 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative nucleic acid ATP-dependent helicase 2563203..2564963 Escherichia coli ED1a 7140123 YP_002398546.1 CDS rplY NC_011745.1 2565088 2565372 D the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 2565088..2565372 Escherichia coli ED1a 7143955 YP_002398547.1 CDS yejK NC_011745.1 2565511 2566518 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99296598, 10368163; Product type f : factor; nucleoid-associated protein NdpA complement(2565511..2566518) Escherichia coli ED1a 7141474 YP_002398548.1 CDS yejL NC_011745.1 2566700 2566927 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2566700..2566927 Escherichia coli ED1a 7143956 YP_002398549.1 CDS yejM NC_011745.1 2566947 2568707 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase, inner membrane-associated 2566947..2568707 Escherichia coli ED1a 7143957 YP_002398550.1 CDS intA NC_011745.1 2569059 2570318 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; integrase from prophage 2569059..2570318 Escherichia coli ED1a 7142523 YP_002398551.1 CDS ECED1_2641 NC_011745.1 2570396 2570647 D Evidence 6 : Doubtful CDS; hypothetical protein 2570396..2570647 Escherichia coli ED1a 7141183 YP_002398552.1 CDS ECED1_2642 NC_011745.1 2570815 2571021 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2570815..2571021 Escherichia coli ED1a 7140694 YP_002398553.1 CDS ECED1_2643 NC_011745.1 2571170 2571358 R Evidence 6 : Doubtful CDS; Product type h : extrachromosomal origin; hypothetical protein complement(2571170..2571358) Escherichia coli ED1a 7140695 YP_002398554.1 CDS ECED1_2644 NC_011745.1 2571401 2571592 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; putative repressor complement(2571401..2571592) Escherichia coli ED1a 7140696 YP_002398555.1 CDS ECED1_2645 NC_011745.1 2571628 2572284 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8491703; Product type h : extrachromosomal origin; putative lcd-like protein from phage origin (C-term) 2571628..2572284 Escherichia coli ED1a 7140697 YP_002398556.1 CDS ECED1_2646 NC_011745.1 2572238 2572597 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2572238..2572597 Escherichia coli ED1a 7140698 YP_002398557.1 CDS ECED1_2647 NC_011745.1 2572604 2572903 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2572604..2572903 Escherichia coli ED1a 7140699 YP_002398558.1 CDS ECED1_2648 NC_011745.1 2572885 2575041 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2572885..2575041 Escherichia coli ED1a 7140700 YP_002398559.1 CDS ECED1_2649 NC_011745.1 2575640 2576062 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative single stranded DNA-binding protein of prophage 2575640..2576062 Escherichia coli ED1a 7140701 YP_002398560.1 CDS ECED1_2650 NC_011745.1 2576478 2576684 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2576478..2576684 Escherichia coli ED1a 7140702 YP_002398561.1 CDS gp NC_011745.1 2576684 2577739 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; major head protein from prophage 2576684..2577739 Escherichia coli ED1a 7140703 YP_002398562.1 CDS ECED1_2652 NC_011745.1 2577752 2578087 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative head decoration protein from prophage 2577752..2578087 Escherichia coli ED1a 7143008 YP_002398563.1 CDS ECED1_2653 NC_011745.1 2578100 2578513 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative head-tail preconnector protein from prophage 2578100..2578513 Escherichia coli ED1a 7140704 YP_002398564.1 CDS ECED1_2654 NC_011745.1 2579176 2579457 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2579176..2579457 Escherichia coli ED1a 7140705 YP_002398565.1 CDS ECED1_2655 NC_011745.1 2579714 2579896 D Evidence 6 : Doubtful CDS; hypothetical protein 2579714..2579896 Escherichia coli ED1a 7140706 YP_002398566.1 CDS ECED1_2656 NC_011745.1 2580599 2581084 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative autotransporter outer membrane protein complement(2580599..2581084) Escherichia coli ED1a 7140707 YP_002398567.1 CDS narP NC_011745.1 2581716 2582363 D nitrate/nitrite response regulator NarP; NarP is phosphorylated by NarX and NarQ and can activate fdnG and nitrite or nitrate reductase systems; represses expression of other anaerobic genes; transcriptional regulator NarP 2581716..2582363 Escherichia coli ED1a 7140708 YP_002398568.1 CDS ccmH NC_011745.1 2582398 2583450 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 11756453, 12196152, 87260957, 91194558, 95362656, 9914305, 7635817; Product type pe : putative enzyme; heme lyase CcmH complement(2582398..2583450) Escherichia coli ED1a 7140363 YP_002398569.1 CDS ccmG NC_011745.1 2583447 2584004 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 12196152, 9716493, 9770295, 11256948, 11350062, 11843181, 7635817, 9537397; Product type e : enzyme; periplasmic thioredoxin of cytochrome c-type biogenesis complement(2583447..2584004) Escherichia coli ED1a 7139322 YP_002398570.1 CDS ccmF NC_011745.1 2584001 2585944 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 11756453, 12196152, 87260957, 8842153, 91194558, 95362656, 9716493, 7635817; Product type e : enzyme; heme lyase CcmF complement(2584001..2585944) Escherichia coli ED1a 7139321 YP_002398571.1 CDS ccmE NC_011745.1 2585941 2586420 R CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane; cytochrome c-type biogenesis protein CcmE complement(2585941..2586420) Escherichia coli ED1a 7139320 YP_002398572.1 CDS ccmD NC_011745.1 2586417 2586626 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 12196152, 95362656, 9716493, 7635817; Product type f : factor; cytochrome c biogenesis protein complement(2586417..2586626) Escherichia coli ED1a 7139319 YP_002398573.1 CDS ccmC NC_011745.1 2586623 2587360 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 12196152, 14532274, 21413853, 95362656, 7635817; Product type t : transporter; heme ABC transporter membrane protein complement(2586623..2587360) Escherichia coli ED1a 7139318 YP_002398574.1 CDS ccmB NC_011745.1 2587402 2588064 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 12196152, 95362656, 9716493, 7635817; Product type t : transporter; heme ABC transporter membrane protein complement(2587402..2588064) Escherichia coli ED1a 7139317 YP_002398575.1 CDS ccmA NC_011745.1 2588061 2588684 R ATP-binding protein; required for proper cytochrome c maturation; cytochrome c biogenesis protein CcmA complement(2588061..2588684) Escherichia coli ED1a 7139316 YP_002398576.1 CDS napC NC_011745.1 2588697 2589299 R with NapABDFGH functions as a nitrate reductase; NapC functions as an electron shuttle between NapAB and NapGH or quinone; cytochrome c-type protein NapC complement(2588697..2589299) Escherichia coli ED1a 7139315 YP_002398577.1 CDS napB NC_011745.1 2589309 2589758 R small subunit of periplasmic nitrate reductase; receives electrons from the membrane-bound NapC and passes them to NapA; citrate reductase cytochrome c-type subunit complement(2589309..2589758) Escherichia coli ED1a 7140352 YP_002398578.1 CDS napH NC_011745.1 2589755 2590618 R part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; quinol dehydrogenase membrane component complement(2589755..2590618) Escherichia coli ED1a 7140351 YP_002398579.1 CDS napG NC_011745.1 2590605 2591300 R part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway; quinol dehydrogenase periplasmic component complement(2590605..2591300) Escherichia coli ED1a 7140356 YP_002398580.1 CDS napA NC_011745.1 2591307 2593793 R periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC; nitrate reductase catalytic subunit complement(2591307..2593793) Escherichia coli ED1a 7140355 YP_002398581.1 CDS napD NC_011745.1 2593790 2594053 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96228696, 99395037; Product type f : factor; assembly protein for periplasmic nitrate reductase complement(2593790..2594053) Escherichia coli ED1a 7140350 YP_002398582.1 CDS napF NC_011745.1 2594043 2594537 R Predicted role in electron transfer to the periplasmic nitrate reductase protein NapA.; ferredoxin-type protein complement(2594043..2594537) Escherichia coli ED1a 7140353 YP_002398583.1 CDS ECED1_2674 NC_011745.1 2594637 2594810 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2594637..2594810 Escherichia coli ED1a 7140354 YP_002398584.1 CDS eco NC_011745.1 2594945 2595433 D serine protease inhibitor, inhibits trypsin and other proteases; ecotin 2594945..2595433 Escherichia coli ED1a 7140709 YP_002398585.1 CDS mqo NC_011745.1 2595583 2597229 R malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; malate:quinone oxidoreductase complement(2595583..2597229) Escherichia coli ED1a 7139769 YP_002398586.1 CDS yojI NC_011745.1 2597447 2599090 R efflux pump for the antibacterial peptide microcin J25; multidrug transporter membrane component/ATP-binding protein complement(2597447..2599090) Escherichia coli ED1a 7139018 YP_002398587.1 CDS alkB NC_011745.1 2599166 2599816 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12226668, 12517444, 12862460, 14527653, 87057220, 88151899, 92017669, 3536913, 3887409, 7928996; Product type e : enzyme; N1-methyladenine or N3-methylcytosine DNA lesion oxidative demethylase complement(2599166..2599816) Escherichia coli ED1a 7140275 YP_002398588.1 CDS ada NC_011745.1 2599816 2600880 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91073391, 93272965, 94252990; Product type r : regulator; fused DNA-binding transcriptional dual regulator ; O6-methylguanine-DNA methyltransferase complement(2599816..2600880) Escherichia coli ED1a 7143689 YP_002398589.1 CDS yojL NC_011745.1 2600954 2602009 R catalyzes the conversion of aminoimidazole ribotide to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine moiety of thiamine; involved in the maintenance and/or assembly of sulfur clusters; periplasmic lipoporotein anchored to the inner membrane; part of the thiamine pyrophosphate biosynthesis pathway; thiamine biosynthesis lipoprotein ApbE complement(2600954..2602009) Escherichia coli ED1a 7143657 YP_002398590.1 CDS ompC NC_011745.1 2602121 2603248 R allows for ions and hydrophilic solutes to cross the outer membrane; outer membrane porin protein C complement(2602121..2603248) Escherichia coli ED1a 7140276 YP_002398591.1 CDS rcsD NC_011745.1 2603987 2606659 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11758943, 12864862, 21206231, 2404948, 7984428; Product type r : regulator; phosphotransfer intermediate protein in two-component regulatory system with RcsBC 2603987..2606659 Escherichia coli ED1a 7138983 YP_002398592.1 CDS rcsB NC_011745.1 2606676 2607326 D two-component response regulator RscB regulates the genes involved in capsule biosynthesis and cell division; probably phosphorylated by RcsC or RcsF; transcriptional regulator RcsB 2606676..2607326 Escherichia coli ED1a 7143439 YP_002398593.1 CDS rcsC NC_011745.1 2607412 2610213 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11758943, 12864862, 14651646, 20032358, 21450811, 88227838, 90130299, 92048476, 9209051, 2404948, 8366025; Product type r : regulator; hybrid sensory kinase in two-component regulatory system with RcsB and YojN complement(2607412..2610213) Escherichia coli ED1a 7141264 YP_002398594.1 CDS atoS NC_011745.1 2610428 2612254 D with AtoC is a member of a two-component regulatory system involved in the transcriptional regulation of the ato genes for acetoacetate metabolism; sensory histidine kinase AtoS 2610428..2612254 Escherichia coli ED1a 7141265 YP_002398595.1 CDS atoC NC_011745.1 2612251 2613636 D with AtoS is a two-component regulatory system involved in the transcriptional regulation of the ato genes for acetoacetate metabolism; acetoacetate metabolism regulatory protein AtoC 2612251..2613636 Escherichia coli ED1a 7140407 YP_002398596.1 CDS atoD NC_011745.1 2613832 2614494 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 73032600, 87083402; Product type c : carrier; acetyl-CoA:acetoacetyl-CoA transferase subunit alpha 2613832..2614494 Escherichia coli ED1a 7142661 YP_002398597.1 CDS atoA NC_011745.1 2614494 2615144 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 73032600, 87083402; Product type c : carrier; acetyl-CoA:acetoacetyl-CoA transferase subunit beta 2614494..2615144 Escherichia coli ED1a 7141944 YP_002398598.1 CDS ECED1_2689 NC_011745.1 2615134 2615295 D Evidence 6 : Doubtful CDS; hypothetical protein 2615134..2615295 Escherichia coli ED1a 7142659 YP_002398599.1 CDS atoE NC_011745.1 2615141 2616463 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 73032600, 87083402; Product type t : transporter; short chain fatty acid transporter 2615141..2616463 Escherichia coli ED1a 7144034 YP_002398600.1 CDS atoB NC_011745.1 2616494 2617678 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 73032600, 87083402; Product type c : carrier; acetyl-CoA acetyltransferase 2616494..2617678 Escherichia coli ED1a 7140406 YP_002398601.1 CDS yfaP NC_011745.1 2617752 2618528 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2617752..2618528) Escherichia coli ED1a 7142660 YP_002398602.1 CDS yfaQ NC_011745.1 2618533 2620182 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2618533..2620182) Escherichia coli ED1a 7143964 YP_002398603.1 CDS ECED1_2694 NC_011745.1 2620183 2624802 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative large extracellular alpha-helical protein complement(2620183..2624802) Escherichia coli ED1a 7143965 YP_002398604.1 CDS yfaT NC_011745.1 2624721 2625344 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2624721..2625344) Escherichia coli ED1a 7143872 YP_002398605.1 CDS yfaA NC_011745.1 2625341 2627029 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2625341..2627029) Escherichia coli ED1a 7143966 YP_002398606.1 CDS gyrA NC_011745.1 2627178 2629805 R negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A complement(2627178..2629805) Escherichia coli ED1a 7143959 YP_002398607.1 CDS ubiG NC_011745.1 2629952 2630674 D Involved in ubiquinone biosynthesis; 3-demethylubiquinone-9 3-methyltransferase 2629952..2630674 Escherichia coli ED1a 7139852 YP_002398608.1 CDS yfaL NC_011745.1 2630814 2634578 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15659678; Product type f : factor; adhesin complement(2630814..2634578) Escherichia coli ED1a 7140862 YP_002398609.1 CDS nrdA NC_011745.1 2635254 2637539 D Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 2635254..2637539 Escherichia coli ED1a 7143962 YP_002398610.1 CDS nrdB NC_011745.1 2637729 2638859 D B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA; ribonucleotide-diphosphate reductase subunit beta 2637729..2638859 Escherichia coli ED1a 7139919 YP_002398611.1 CDS yfaE NC_011745.1 2638859 2639113 D plays a role in maintenance and possibly the biosynthesis of diferric-tyrosyl radical cofactor, essential for nucleotide reduction catalyzed by ribonucleotide reductases; 2Fe-2S ferredoxin YfaE 2638859..2639113 Escherichia coli ED1a 7139920 YP_002398612.1 CDS inaA NC_011745.1 2639167 2639817 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 92165728, 1537798, 6087316; hypothetical protein complement(2639167..2639817) Escherichia coli ED1a 7143961 YP_002398613.1 CDS glpQ NC_011745.1 2640020 2641096 R hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic; glycerophosphodiester phosphodiesterase complement(2640020..2641096) Escherichia coli ED1a 7141108 YP_002398614.1 CDS glpT NC_011745.1 2641101 2642459 R catalyzes the uptake of glycerol-3-phosphate into the cell with the simultaneous export of inorganic phosphate from the cell; sn-glycerol-3-phosphate transporter complement(2641101..2642459) Escherichia coli ED1a 7142974 YP_002398615.1 CDS glpA NC_011745.1 2642732 2644360 D anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor; sn-glycerol-3-phosphate dehydrogenase subunit A 2642732..2644360 Escherichia coli ED1a 7142976 YP_002398616.1 CDS glpB NC_011745.1 2644350 2645609 D sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters; anaerobic glycerol-3-phosphate dehydrogenase subunit B 2644350..2645609 Escherichia coli ED1a 7142966 YP_002398617.1 CDS glpC NC_011745.1 2645606 2646796 D anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate; sn-glycerol-3-phosphate dehydrogenase subunit C 2645606..2646796 Escherichia coli ED1a 7142967 YP_002398618.1 CDS yfaD NC_011745.1 2646989 2647900 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2646989..2647900 Escherichia coli ED1a 7142968 YP_002398619.1 CDS ypaA NC_011745.1 2647910 2648134 D Evidence 7 : Gene remnant; hypothetical protein 2647910..2648134 Escherichia coli ED1a 7143960 YP_002398620.1 CDS yfaU NC_011745.1 2648175 2648978 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12454498, 16511168, 8550403; Product type pe : putative enzyme; putative aldolase complement(2648175..2648978) Escherichia coli ED1a 7140277 YP_002398621.1 CDS yfaV NC_011745.1 2648996 2650285 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative carboxylate transporter; phthalate permease family complement(2648996..2650285) Escherichia coli ED1a 7143967 YP_002398622.1 CDS yfaW NC_011745.1 2650342 2651559 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative epimerase/enolase/dehydratase complement(2650342..2651559) Escherichia coli ED1a 7143968 YP_002398623.1 CDS yfaX NC_011745.1 2651562 2652344 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(2651562..2652344) Escherichia coli ED1a 7143969 YP_002398624.1 CDS yfaY NC_011745.1 2652564 2653766 R Evidence 4 : Homologs of previously reported genes of unknown function; competence damage-inducible protein A complement(2652564..2653766) Escherichia coli ED1a 7143970 YP_002398625.1 CDS yfaZ NC_011745.1 2653866 2654408 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative outer membrane porin protein complement(2653866..2654408) Escherichia coli ED1a 7143971 YP_002398626.1 CDS yfaO NC_011745.1 2654687 2655112 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16430214; Product type pe : putative enzyme; putative NUDIX hydrolase 2654687..2655112 Escherichia coli ED1a 7143972 YP_002398627.1 CDS ais NC_011745.1 2655151 2655753 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2655151..2655753) Escherichia coli ED1a 7143963 YP_002398628.1 CDS yfbE NC_011745.1 2656043 2657200 D catalyzes the conversion of UDP-4-keto-arabinose to UDP-4-amino-4-deoxy-L-arabinose; UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase 2656043..2657200 Escherichia coli ED1a 7143684 YP_002398629.1 CDS yfbF NC_011745.1 2657204 2658172 D catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate; undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase 2657204..2658172 Escherichia coli ED1a 7143974 YP_002398630.1 CDS yfbG NC_011745.1 2658172 2660154 D Bifunctional polymyxin resistance arnA protein; catalyzes the decarboxylation of UDP-glucuronic acid to UDP-4-keto-arabinose and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose to form UDP-L-4-formamido-arabinose; active in certain mutant strains; bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase 2658172..2660154 Escherichia coli ED1a 7143975 YP_002398631.1 CDS yfbH NC_011745.1 2660151 2661041 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2660151..2661041 Escherichia coli ED1a 7143976 YP_002398632.1 CDS arnT NC_011745.1 2661041 2662693 D catalyzes the addition of 4-amino-4-deoxy-L-arabinose to lipid A; 4-amino-4-deoxy-L-arabinose transferase 2661041..2662693 Escherichia coli ED1a 7143977 YP_002398633.1 CDS yfbW NC_011745.1 2662690 2663025 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2662690..2663025 Escherichia coli ED1a 7142622 YP_002398634.1 CDS yfbJ NC_011745.1 2662743 2663411 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2662743..2663411 Escherichia coli ED1a 7143988 YP_002398635.1 CDS pmrD NC_011745.1 2663405 2663671 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96015440, 15569938; Product type pt : putative transporter; polymyxin resistance protein B complement(2663405..2663671) Escherichia coli ED1a 7143978 YP_002398636.1 CDS menE NC_011745.1 2663781 2665136 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96186953, 8626063; Product type e : enzyme; O-succinylbenzoic acid--CoA ligase complement(2663781..2665136) Escherichia coli ED1a 7139074 YP_002398637.1 CDS menC NC_011745.1 2665133 2666095 R catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase complement(2665133..2666095) Escherichia coli ED1a 7142245 YP_002398638.1 CDS menB NC_011745.1 2666095 2666952 R catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase complement(2666095..2666952) Escherichia coli ED1a 7142243 YP_002398639.1 CDS yfbB NC_011745.1 2666967 2667725 R catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; acyl-CoA thioester hydrolase YfbB complement(2666967..2667725) Escherichia coli ED1a 7142242 YP_002398640.1 CDS menD NC_011745.1 2667722 2669392 R SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase complement(2667722..2669392) Escherichia coli ED1a 7143973 YP_002398641.1 CDS menF NC_011745.1 2669481 2670776 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9150206, 96140724, 2666397, 7984428, 8549818, 8764478; Product type e : enzyme; isochorismate synthase 2 complement(2669481..2670776) Escherichia coli ED1a 7142244 YP_002398642.1 CDS elaB NC_011745.1 2670855 2671160 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2670855..2671160) Escherichia coli ED1a 7142246 YP_002398643.1 CDS elaA NC_011745.1 2671215 2671676 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein complement(2671215..2671676) Escherichia coli ED1a 7139782 YP_002398644.1 CDS elaC NC_011745.1 2671741 2672658 D member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 2671741..2672658 Escherichia coli ED1a 7139781 YP_002398645.1 CDS yfbK NC_011745.1 2672779 2674521 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2672779..2674521) Escherichia coli ED1a 7139783 YP_002398646.1 CDS yfbL NC_011745.1 2674659 2675630 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-associated peptidase 2674659..2675630 Escherichia coli ED1a 7143979 YP_002398647.1 CDS yfbM NC_011745.1 2675733 2676236 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2675733..2676236 Escherichia coli ED1a 7143980 YP_002398648.1 CDS nuoN NC_011745.1 2676303 2677760 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit N complement(2676303..2677760) Escherichia coli ED1a 7143981 YP_002398649.1 CDS nuoM NC_011745.1 2677767 2679296 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit M complement(2677767..2679296) Escherichia coli ED1a 7139956 YP_002398650.1 CDS nuoL NC_011745.1 2679460 2681301 R Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit L complement(2679460..2681301) Escherichia coli ED1a 7139955 YP_002398651.1 CDS nuoK NC_011745.1 2681298 2681600 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit K complement(2681298..2681600) Escherichia coli ED1a 7139954 YP_002398652.1 CDS nuoJ NC_011745.1 2681597 2682151 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit J complement(2681597..2682151) Escherichia coli ED1a 7139953 YP_002398653.1 CDS nuoI NC_011745.1 2682163 2682705 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I complement(2682163..2682705) Escherichia coli ED1a 7139952 YP_002398654.1 CDS nuoH NC_011745.1 2682720 2683697 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit H complement(2682720..2683697) Escherichia coli ED1a 7139951 YP_002398655.1 CDS nuoG NC_011745.1 2683694 2686426 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit G complement(2683694..2686426) Escherichia coli ED1a 7139950 YP_002398656.1 CDS nuoF NC_011745.1 2686473 2687810 R shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase; NADH dehydrogenase I subunit F complement(2686473..2687810) Escherichia coli ED1a 7139949 YP_002398657.1 CDS nuoE NC_011745.1 2687807 2688307 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit E complement(2687807..2688307) Escherichia coli ED1a 7139948 YP_002398658.1 CDS nuoC NC_011745.1 2688310 2690112 R NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms; bifunctional NADH:ubiquinone oxidoreductase subunit C/D complement(2688310..2690112) Escherichia coli ED1a 7139947 YP_002398659.1 CDS nuoB NC_011745.1 2690206 2690868 R The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B complement(2690206..2690868) Escherichia coli ED1a 7139946 YP_002398660.1 CDS nuoA NC_011745.1 2690884 2691327 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit A complement(2690884..2691327) Escherichia coli ED1a 7139945 YP_002398661.1 CDS lrhA NC_011745.1 2691957 2692895 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12123461, 9882671, 7565112; Product type r : regulator; DNA-binding transcriptional repressor of flagellar, motility and chemotaxis genes complement(2691957..2692895) Escherichia coli ED1a 7139944 YP_002398662.1 CDS yfbQ NC_011745.1 2693815 2695032 D broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase AlaT 2693815..2695032 Escherichia coli ED1a 7141925 YP_002398663.1 CDS yfbR NC_011745.1 2695116 2695715 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15489502; Product type e : enzyme; hypothetical protein 2695116..2695715 Escherichia coli ED1a 7143982 YP_002398664.1 CDS yfbS NC_011745.1 2695774 2697606 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter complement(2695774..2697606) Escherichia coli ED1a 7143983 YP_002398665.1 CDS yfbT NC_011745.1 2697693 2698343 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphatase complement(2697693..2698343) Escherichia coli ED1a 7143984 YP_002398666.1 CDS yfbU NC_011745.1 2698354 2698848 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2698354..2698848) Escherichia coli ED1a 7143985 YP_002398667.1 CDS yfbV NC_011745.1 2698931 2699386 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(2698931..2699386) Escherichia coli ED1a 7143986 YP_002398668.1 CDS ackA NC_011745.1 2699724 2700926 D AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 2699724..2700926 Escherichia coli ED1a 7143987 YP_002398669.1 CDS pta NC_011745.1 2701001 2703145 D catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 2701001..2703145 Escherichia coli ED1a 7143641 YP_002398670.1 CDS yfcC NC_011745.1 2703335 2704855 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pc : putative carrier; hypothetical protein 2703335..2704855 Escherichia coli ED1a 7141201 YP_002398671.1 CDS yfcD NC_011745.1 2704889 2705431 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16430214; Product type pe : putative enzyme; putative NUDIX hydrolase complement(2704889..2705431) Escherichia coli ED1a 7143990 YP_002398672.1 CDS yfcE NC_011745.1 2705489 2706043 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; phosphodiesterase complement(2705489..2706043) Escherichia coli ED1a 7143991 YP_002398673.1 CDS yfcF NC_011745.1 2706096 2706740 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein complement(2706096..2706740) Escherichia coli ED1a 7143992 YP_002398674.1 CDS yfcG NC_011745.1 2706876 2707523 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; glutathione S-transferase 2706876..2707523 Escherichia coli ED1a 7143993 YP_002398675.1 CDS folX NC_011745.1 2707580 2707942 D catalyzes the formation of dihydromonapterin triphosphate from dihydroneopterin triphosphate; D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase 2707580..2707942 Escherichia coli ED1a 7143994 YP_002398676.1 CDS yfcH NC_011745.1 2707963 2708856 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pe : putative enzyme; hypothetical protein 2707963..2708856 Escherichia coli ED1a 7142163 YP_002398677.1 CDS yfcI NC_011745.1 2708904 2709794 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transposase complement(2708904..2709794) Escherichia coli ED1a 7143995 YP_002398678.1 CDS hisP NC_011745.1 2709990 2710763 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10373434, 3313284, 91060556; Product type t : transporter; histidine/lysine/arginine/ornithine transporter subunit complement(2709990..2710763) Escherichia coli ED1a 7143996 YP_002398679.1 CDS hisM NC_011745.1 2710771 2711487 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10373434, 3313284; Product type t : transporter; histidine/lysine/arginine/ornithine ABC transporter membrane protein complement(2710771..2711487) Escherichia coli ED1a 7139898 YP_002398680.1 CDS hisQ NC_011745.1 2711484 2712170 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10373434; Product type t : transporter; histidine/lysine/arginine/ornithine ABC transporter membrane protein complement(2711484..2712170) Escherichia coli ED1a 7139897 YP_002398681.1 CDS hisJ NC_011745.1 2712260 2713042 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10373434, 6449635, 8161536, 9298646, 9600841, 9740056; Product type t : transporter; histidine/lysine/arginine/ornithine ABC transporter subunit periplasmic-binding protein complement(2712260..2713042) Escherichia coli ED1a 7139899 YP_002398682.1 CDS argT NC_011745.1 2713263 2714045 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 4583243, 87308226, 3040734, 9298646; Product type t : transporter; lysine/arginine/ornithine ABC transporter subunit periplasmic-binding protein complement(2713263..2714045) Escherichia coli ED1a 7139895 YP_002398683.1 CDS ubiX NC_011745.1 2714311 2714880 R catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase complement(2714311..2714880) Escherichia coli ED1a 7142621 YP_002398684.1 CDS purF NC_011745.1 2714975 2716492 R Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase complement(2714975..2716492) Escherichia coli ED1a 7140864 YP_002398685.1 CDS cvpA NC_011745.1 2716529 2717017 R membrane protein required for colicin V production; colicin V production protein complement(2716529..2717017) Escherichia coli ED1a 7141218 YP_002398686.1 CDS dedD NC_011745.1 2717367 2718029 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3040734; hypothetical protein complement(2717367..2718029) Escherichia coli ED1a 7142091 YP_002398687.1 CDS folC NC_011745.1 2718019 2719287 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3040739, 91112811, 92041808, 1989505, 3040734; Product type e : enzyme; bifunctional folylpolyglutamate synthase/ dihydrofolate synthase complement(2718019..2719287) Escherichia coli ED1a 7143084 YP_002398688.1 CDS accD NC_011745.1 2719357 2720271 R catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta complement(2719357..2720271) Escherichia coli ED1a 7142157 YP_002398689.1 CDS dedA NC_011745.1 2720427 2721086 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3029016, 3040734, 7678242; Product type pm : putative membrane component; hypothetical protein complement(2720427..2721086) Escherichia coli ED1a 7143635 YP_002398690.1 CDS truA NC_011745.1 2721169 2721981 R mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A complement(2721169..2721981) Escherichia coli ED1a 7143083 YP_002398691.1 CDS usg NC_011745.1 2721981 2722994 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 92380957, 92380982, 93123150, 2681152, 2991861, 3029016; Product type pe : putative enzyme; putative semialdehyde dehydrogenase complement(2721981..2722994) Escherichia coli ED1a 7140827 YP_002398692.1 CDS pdxB NC_011745.1 2723060 2724196 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90036695, 91035267, 2681152, 2991861, 3029016; Product type e : enzyme; erythronate-4-phosphate dehydrogenase complement(2723060..2724196) Escherichia coli ED1a 7139143 YP_002398693.1 CDS flk NC_011745.1 2724295 2725290 D in Salmonella typhimurium Flk regulates flagellar biosynthesis by inhibition of the flagellar-associated type III secretion system; lowers secretion levels of the anti-sigma28 factor FlgM to the periplasm; inner membrane-anchored protein; flagella biosynthesis regulator 2724295..2725290 Escherichia coli ED1a 7144053 YP_002398694.1 CDS yfcJ NC_011745.1 2725287 2726465 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; hypothetical protein complement(2725287..2726465) Escherichia coli ED1a 7142150 YP_002398695.1 CDS fabB NC_011745.1 2726730 2727950 R FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase I complement(2726730..2727950) Escherichia coli ED1a 7143997 YP_002398696.1 CDS mnmC NC_011745.1 2728109 2730115 D catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules; 5-methylaminomethyl-2-thiouridine methyltransferase 2728109..2730115 Escherichia coli ED1a 7139838 YP_002398697.1 CDS yfcL NC_011745.1 2730236 2730514 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2730236..2730514) Escherichia coli ED1a 7140814 YP_002398698.1 CDS yfcM NC_011745.1 2730548 2731096 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2730548..2731096) Escherichia coli ED1a 7143998 YP_002398699.1 CDS yfcA NC_011745.1 2731096 2731905 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(2731096..2731905) Escherichia coli ED1a 7143999 YP_002398700.1 CDS mepA NC_011745.1 2731905 2732729 R D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm; penicillin-insensitive murein endopeptidase complement(2731905..2732729) Escherichia coli ED1a 7143989 YP_002398701.1 CDS aroC NC_011745.1 2732733 2733818 R catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase complement(2732733..2733818) Escherichia coli ED1a 7142247 YP_002398702.1 CDS prmB NC_011745.1 2733853 2734785 R involved in methylation of ribosomal protein L3; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase complement(2733853..2734785) Escherichia coli ED1a 7142625 YP_002398703.1 CDS yfcN NC_011745.1 2734951 2735502 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2734951..2735502 Escherichia coli ED1a 7139125 YP_002398704.1 CDS ECED1_2796 NC_011745.1 2735826 2736683 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2735826..2736683) Escherichia coli ED1a 7144000 YP_002398705.1 CDS yfcP NC_011745.1 2736670 2737197 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative exported fimbrial-like adhesin protein complement(2736670..2737197) Escherichia coli ED1a 7143873 YP_002398706.1 CDS yfcQ NC_011745.1 2737194 2737673 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin exported protein complement(2737194..2737673) Escherichia coli ED1a 7144001 YP_002398707.1 CDS yfcR NC_011745.1 2737670 2738239 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin exported protein complement(2737670..2738239) Escherichia coli ED1a 7144002 YP_002398708.1 CDS yfcS NC_011745.1 2738190 2738942 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative periplasmic pilus exported chaperone complement(2738190..2738942) Escherichia coli ED1a 7144003 YP_002398709.1 CDS yfcU NC_011745.1 2738962 2741616 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative export usher protein complement(2738962..2741616) Escherichia coli ED1a 7144004 YP_002398710.1 CDS yfcV NC_011745.1 2741691 2742257 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin exported protein complement(2741691..2742257) Escherichia coli ED1a 7144005 YP_002398711.1 CDS sixA NC_011745.1 2742824 2743309 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10089421, 20200300, 9489669; Product type e : enzyme; phosphohistidine phosphatase complement(2742824..2743309) Escherichia coli ED1a 7144006 YP_002398712.1 CDS fadJ NC_011745.1 2743512 2745656 R multifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities: forms a heterotetramer with FadI; similar to FadA2B2 complex; involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate; multifunctional fatty acid oxidation complex subunit alpha complement(2743512..2745656) Escherichia coli ED1a 7143802 YP_002398713.1 CDS fadI NC_011745.1 2745656 2746966 R FadI; fatty acid oxidation complex component beta; functions in a heterotetramer with FadJ; similar to FadA2B2 complex; functions in beta-oxidation of fatty acids during anaerobic growth; 3-ketoacyl-CoA thiolase complement(2745656..2746966) Escherichia coli ED1a 7144007 YP_002398714.1 CDS yfcZ NC_011745.1 2747148 2747432 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2747148..2747432) Escherichia coli ED1a 7144008 YP_002398715.1 CDS fadL NC_011745.1 2747798 2749144 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15178802, 2840553, 3286621, 91100327, 1987139, 9119048; Product type t : transporter; long-chain fatty acid outer membrane transporter 2747798..2749144 Escherichia coli ED1a 7144009 YP_002398716.1 CDS vacJ NC_011745.1 2749206 2749961 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8145644, 15352239; Product type lp : lipoprotein; putative lipoprotein complement(2749206..2749961) Escherichia coli ED1a 7144129 YP_002398717.1 CDS ECED1_2809 NC_011745.1 2749987 2750157 R Evidence 6 : Doubtful CDS; hypothetical protein complement(2749987..2750157) Escherichia coli ED1a 7139164 YP_002398718.1 CDS yfdC NC_011745.1 2750255 2751187 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2750255..2751187 Escherichia coli ED1a 7143874 YP_002398719.1 CDS dsdC NC_011745.1 2751437 2752372 R regulates the synthesis and expression of the dsdXA operon and dadA gene; DNA-binding transcriptional regulator DsdC complement(2751437..2752372) Escherichia coli ED1a 7141409 YP_002398720.1 CDS dsdX NC_011745.1 2752590 2753927 D member of the Gnt family of gluconate transporters; not involved in gluconate transport; unknown function; permease DsdX 2752590..2753927 Escherichia coli ED1a 7140526 YP_002398721.1 CDS dsdA NC_011745.1 2753945 2755273 D catalyzes the formation of pyruvate from serine; D-serine dehydratase 2753945..2755273 Escherichia coli ED1a 7140527 YP_002398722.1 CDS emrY NC_011745.1 2755381 2756919 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20378313; Product type pt : putative transporter; putative multidrug efflux system complement(2755381..2756919) Escherichia coli ED1a 7140525 YP_002398723.1 CDS emrK NC_011745.1 2756919 2758082 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20378313; Product type t : transporter; EmrKY-TolC multidrug resistance efflux pump, membrane fusion protein component complement(2756919..2758082) Escherichia coli ED1a 7139790 YP_002398724.1 CDS evgA NC_011745.1 2758498 2759112 D response regulator in two-component regulatory system with EvgS; phosphorylated EvgA activates ompC, emrKY, gadABC, hdeAB and others genes; involved in acid resistance, osmotic adaption, and drug resistance; DNA-binding transcriptional activator EvgA 2758498..2759112 Escherichia coli ED1a 7139789 YP_002398725.1 CDS evgS NC_011745.1 2759117 2762710 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14523115, 93173621, 9501520, 10923791, 1289796, 8125343, 9535079; Product type r : regulator; hybrid sensory histidine kinase in two-component regulatory system with EvgA 2759117..2762710 Escherichia coli ED1a 7139828 YP_002398726.1 CDS yfdE NC_011745.1 2762766 2763911 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein complement(2762766..2763911) Escherichia coli ED1a 7139829 YP_002398727.1 CDS yfdV NC_011745.1 2763985 2764929 R member of the AEC family of auxin efflux transporters; unknown function; putative transporter YfdV complement(2763985..2764929) Escherichia coli ED1a 7144011 YP_002398728.1 CDS oxc NC_011745.1 2764999 2766693 R catalyzes the formation of formyl-CoA from oxalyl-CoA; putative oxalyl-CoA decarboxylase complement(2764999..2766693) Escherichia coli ED1a 7144014 YP_002398729.1 CDS frc NC_011745.1 2766747 2767997 R catalyzes the formation of oxalyl-CoA from oxalate and Formyl-CoA; formyl-coenzyme A transferase complement(2766747..2767997) Escherichia coli ED1a 7139993 YP_002398730.1 CDS yfdX NC_011745.1 2768509 2769141 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11157960; hypothetical protein complement(2768509..2769141) Escherichia coli ED1a 7142165 YP_002398731.1 CDS ypdI NC_011745.1 2769436 2769711 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15183873; Product type lp : lipoprotein; putative lipoprotein 2769436..2769711 Escherichia coli ED1a 7144015 YP_002398732.1 CDS yfdY NC_011745.1 2769788 2770030 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14727089; Product type pm : putative membrane component; hypothetical protein complement(2769788..2770030) Escherichia coli ED1a 7140286 YP_002398733.1 CDS ddg NC_011745.1 2770383 2771303 D Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(palmitoleoyl)-lipid IVA in cells subjected to cold shock; lipid A biosynthesis palmitoleoyl acyltransferase 2770383..2771303 Escherichia coli ED1a 7144016 YP_002398734.1 CDS yfdZ NC_011745.1 2771795 2773033 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; aminotransferase complement(2771795..2773033) Escherichia coli ED1a 7140757 YP_002398735.1 CDS ypdA NC_011745.1 2773410 2775107 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15522865; Product type prc : putative receptor; putative sensory kinase in two-component system with YpdB 2773410..2775107 Escherichia coli ED1a 7144017 YP_002398736.1 CDS ypdB NC_011745.1 2775104 2775859 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15522865; Product type pr : putative regulator; putative response regulator in two-component system with YpdA 2775104..2775859 Escherichia coli ED1a 7140278 YP_002398737.1 CDS ypdC NC_011745.1 2775872 2776729 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding protein 2775872..2776729 Escherichia coli ED1a 7140279 YP_002398738.1 CDS ypdD NC_011745.1 2776732 2779227 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative fused PTS enzymes (multiphosphoryl transfer protein): Hpr component ; enzyme I component ; enzyme IIA component complement(2776732..2779227) Escherichia coli ED1a 7140280 YP_002398739.1 CDS ypdE NC_011745.1 2779252 2780289 R metalloprotein; exoaminopeptidase complement(2779252..2780289) Escherichia coli ED1a 7140281 YP_002398740.1 CDS ypdF NC_011745.1 2780289 2781374 R Xaa-Pro aminopeptidase; limited methionine aminopeptidase; aminopeptidase complement(2780289..2781374) Escherichia coli ED1a 7140282 YP_002398741.1 CDS ypdG NC_011745.1 2781390 2782637 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative enzyme IIC component of PTS complement(2781390..2782637) Escherichia coli ED1a 7140283 YP_002398742.1 CDS ypdH NC_011745.1 2782659 2782985 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative enzyme IIB component of PTS complement(2782659..2782985) Escherichia coli ED1a 7140284 YP_002398743.1 CDS glk NC_011745.1 2783204 2784169 R catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate; glucokinase complement(2783204..2784169) Escherichia coli ED1a 7140285 YP_002398744.1 CDS yfeO NC_011745.1 2784373 2785629 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; hypothetical protein 2784373..2785629 Escherichia coli ED1a 7143191 YP_002398745.1 CDS ypeC NC_011745.1 2785744 2786070 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2785744..2786070 Escherichia coli ED1a 7144026 YP_002398746.1 CDS mntH NC_011745.1 2786211 2787449 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20177822, 20305051, 10712688, 10844693; Product type t : transporter; manganese transport protein MntH complement(2786211..2787449) Escherichia coli ED1a 7140289 YP_002398747.1 CDS nupC NC_011745.1 2787785 2788987 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 374403, 8022285, 7007808, 827549, 4563236, 1512211; Product type t : transporter; nucleoside (except guanosine) transporter 2787785..2788987 Escherichia coli ED1a 7138994 YP_002398748.1 CDS insM NC_011745.1 2790888 2791190 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS600 2790888..2791190 Escherichia coli ED1a 7144018 YP_002398749.1 CDS ECED1_2842 NC_011745.1 2791226 2792044 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS600 2791226..2792044 Escherichia coli ED1a 7141167 YP_002398750.1 CDS ECED1_2844 NC_011745.1 2792589 2792747 R Evidence 6 : Doubtful CDS; hypothetical protein complement(2792589..2792747) Escherichia coli ED1a 7144019 YP_002398751.1 CDS yfeC NC_011745.1 2793010 2793354 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative nucleic acid-binding transcriptional regulator 2793010..2793354 Escherichia coli ED1a 7140620 YP_002398752.1 CDS yfeD NC_011745.1 2793356 2793748 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative nucleic acid-binding transcriptional regulator 2793356..2793748 Escherichia coli ED1a 7144020 YP_002398753.1 CDS gltX NC_011745.1 2793799 2795214 R Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase complement(2793799..2795214) Escherichia coli ED1a 7144021 YP_002398754.1 CDS xapR NC_011745.1 2795981 2796865 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10400599, 7007808, 2201776, 7559336; Product type r : regulator; DNA-binding transcriptional activator XapR complement(2795981..2796865) Escherichia coli ED1a 7140573 YP_002398755.1 CDS xapB NC_011745.1 2797117 2798373 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96032385, 7559336; Product type t : transporter; xanthosine transporter complement(2797117..2798373) Escherichia coli ED1a 7139201 YP_002398756.1 CDS xapA NC_011745.1 2798434 2799267 R catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase complement(2798434..2799267) Escherichia coli ED1a 7139200 YP_002398757.1 CDS yfeN NC_011745.1 2799516 2800280 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 2799516..2800280 Escherichia coli ED1a 7139199 YP_002398758.1 CDS yfeR NC_011745.1 2800319 2801245 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(2800319..2801245) Escherichia coli ED1a 7144025 YP_002398759.1 CDS yfeH NC_011745.1 2801335 2802333 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative sodium/bile acid symporter family (mazG-like) 2801335..2802333 Escherichia coli ED1a 7144027 YP_002398760.1 CDS ypeB NC_011745.1 2802330 2802548 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2802330..2802548) Escherichia coli ED1a 7144023 YP_002398761.1 CDS ligA NC_011745.1 2802550 2804565 R this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA complement(2802550..2804565) Escherichia coli ED1a 7140288 YP_002398762.1 CDS zipA NC_011745.1 2804636 2805622 R interacts with cell division protein FitsZ and may be required to anchor septal ring structure; cell division protein ZipA complement(2804636..2805622) Escherichia coli ED1a 7141885 YP_002398763.1 CDS cysZ NC_011745.1 2805864 2806625 D putative role in sulfur assimilation; putative sulfate transport protein CysZ 2805864..2806625 Escherichia coli ED1a 7143274 YP_002398764.1 CDS cysK NC_011745.1 2806810 2807781 D CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis; cysteine synthase A 2806810..2807781 Escherichia coli ED1a 7143048 YP_002398765.1 CDS ptsH NC_011745.1 2808165 2808422 D Evidence 1b : Function experimentally demonstrated in the studied species; Product type t : transporter; PTS system phosphohistidinoprotein-hexose phosphotransferase subunit Hpr 2808165..2808422 Escherichia coli ED1a 7143040 YP_002398766.1 CDS ptsI NC_011745.1 2808467 2810194 D Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system; phosphoenolpyruvate-protein phosphotransferase 2808467..2810194 Escherichia coli ED1a 7141209 YP_002398767.1 CDS crr NC_011745.1 2810235 2810744 D functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose; PTS system glucose-specific transporter subunit 2810235..2810744 Escherichia coli ED1a 7141210 YP_002398768.1 CDS pdxK NC_011745.1 2810787 2811638 R catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxal kinase complement(2810787..2811638) Escherichia coli ED1a 7142058 YP_002398769.1 CDS yfeK NC_011745.1 2811743 2812111 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2811743..2812111 Escherichia coli ED1a 7144056 YP_002398770.1 CDS cysM NC_011745.1 2812129 2813025 R catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide; cysteine synthase B complement(2812129..2813025) Escherichia coli ED1a 7144024 YP_002398771.1 CDS cysA NC_011745.1 2813160 2814257 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90202710, 90264334, 2188958, 7665461; Product type t : transporter; sulfate/thiosulfate transporter subunit complement(2813160..2814257) Escherichia coli ED1a 7143041 YP_002398772.1 CDS cysW NC_011745.1 2814247 2815122 R Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import; sulfate/thiosulfate transporter permease subunit complement(2814247..2815122) Escherichia coli ED1a 7142107 YP_002398773.1 CDS cysU NC_011745.1 2815122 2815955 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90264334, 2188958; Product type t : transporter; sulfate/thiosulfate transporter subunit complement(2815122..2815955) Escherichia coli ED1a 7143047 YP_002398774.1 CDS cysP NC_011745.1 2815955 2816971 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90264335, 2188959, 9298646; Product type t : transporter; thiosulfate transporter subunit complement(2815955..2816971) Escherichia coli ED1a 7143046 YP_002398775.1 CDS ucpA NC_011745.1 2817129 2817920 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 97385354, 2188959, 7984428, 9241368; Product type pe : putative enzyme; short chain dehydrogenase complement(2817129..2817920) Escherichia coli ED1a 7143043 YP_002398776.1 CDS murQ NC_011745.1 2818200 2819096 D catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway; N-acetylmuramic acid-6-phosphate etherase 2818200..2819096 Escherichia coli ED1a 7140865 YP_002398777.1 CDS murP NC_011745.1 2819100 2820524 D belongs to PEP-dependent PTS system; contains the PTS EIIBC domains; involved in uptake of exogenous N-acetylmuramic acid (MurNAc); requires crr-encoded enzyme IIA-glucose component; PTS system N-acetylmuramic acid transporter subunits EIIBC 2819100..2820524 Escherichia coli ED1a 7144028 YP_002398778.1 CDS yfeX NC_011745.1 2820704 2821603 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2820704..2821603) Escherichia coli ED1a 7139053 YP_002398779.1 CDS yfeY NC_011745.1 2821699 2822274 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12900013, 7764507; hypothetical protein complement(2821699..2822274) Escherichia coli ED1a 7144029 YP_002398780.1 CDS yfeZ NC_011745.1 2822335 2822784 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(2822335..2822784) Escherichia coli ED1a 7144030 YP_002398781.1 CDS ypeA NC_011745.1 2822771 2823196 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acetyltransferase complement(2822771..2823196) Escherichia coli ED1a 7144031 YP_002398782.1 CDS amiA NC_011745.1 2823410 2824279 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21348478, 6137479, 87242501, 1903834, 8300522; Product type e : enzyme; N-acetylmuramoyl-l-alanine amidase I 2823410..2824279 Escherichia coli ED1a 7140287 YP_002398783.1 CDS hemF NC_011745.1 2824283 2825182 D catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis; coproporphyrinogen III oxidase 2824283..2825182 Escherichia coli ED1a 7143702 YP_002398784.1 CDS yfeG NC_011745.1 2825188 2826240 R activates the transcription of the ethanolamine utilization operon; transcriptional regulator EutR complement(2825188..2826240) Escherichia coli ED1a 7139870 YP_002398785.1 CDS yffI NC_011745.1 2826286 2826786 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10464203; Product type ps : putative structure; putative ethanolaminosome structural protein with putative role in ethanolamine utilization complement(2826286..2826786) Escherichia coli ED1a 7144022 YP_002398786.1 CDS eutL NC_011745.1 2826877 2827458 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type ps : putative structure; putative carboxysome-related structural protein with putative role in ethanolamine utilization complement(2826877..2827458) Escherichia coli ED1a 7142580 YP_002398787.1 CDS eutC NC_011745.1 2827468 2828355 R catalyzes the formation of acetaldehyde from ethanolamine; ethanolamine ammonia-lyase small subunit complement(2827468..2828355) Escherichia coli ED1a 7139824 YP_002398788.1 CDS eutB NC_011745.1 2828376 2829737 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3905806, 10464203; Product type e : enzyme; ethanolamine ammonia-lyase, large subunit, heavy chain complement(2828376..2829737) Escherichia coli ED1a 7139818 YP_002398789.1 CDS eutA NC_011745.1 2829749 2831152 R ethanolamine utilization protein EutA; reactivating factor for ethanolamine ammonia lyase complement(2829749..2831152) Escherichia coli ED1a 7139817 YP_002398790.1 CDS eutH NC_011745.1 2831149 2832375 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7868611, 10464203; Product type pt : putative transporter; putative ethanolamine transporter complement(2831149..2832375) Escherichia coli ED1a 7139816 YP_002398791.1 CDS eutG NC_011745.1 2832592 2833779 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pe : putative enzyme; putative alcohol dehydrogenase in ethanolamine utilization; ethanolaminosome complement(2832592..2833779) Escherichia coli ED1a 7139821 YP_002398792.1 CDS eutJ NC_011745.1 2833769 2834605 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pf : putative factor; putative chaperonin, ethanolamine utilization protein complement(2833769..2834605) Escherichia coli ED1a 7139820 YP_002398793.1 CDS eutE NC_011745.1 2834616 2836019 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pe : putative enzyme; putative aldehyde dehydrogenase, ethanolamine utilization protein complement(2834616..2836019) Escherichia coli ED1a 7139823 YP_002398794.1 CDS cchB NC_011745.1 2836031 2836318 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type ps : putative structure; putative carboxysome-like ethanolaminosome structural protein, ethanolamine utilization protein complement(2836031..2836318) Escherichia coli ED1a 7139819 YP_002398795.1 CDS cchA NC_011745.1 2836425 2836718 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type ps : putative structure; putative carboxysome-like ethanolaminosome structural protein, ethanolamine utilization protein complement(2836425..2836718) Escherichia coli ED1a 7139314 YP_002398796.1 CDS eutD NC_011745.1 2836757 2837773 R in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; phosphotransacetylase complement(2836757..2837773) Escherichia coli ED1a 7139313 YP_002398797.1 CDS eutT NC_011745.1 2837770 2838573 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pe : putative enzyme; putative cobalamin adenosyltransferase in ethanolamine utilization complement(2837770..2838573) Escherichia coli ED1a 7139822 YP_002398798.1 CDS eutQ NC_011745.1 2838570 2839271 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10464203; hypothetical protein complement(2838570..2839271) Escherichia coli ED1a 7139827 YP_002398799.1 CDS eutP NC_011745.1 2839246 2839725 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pe : putative enzyme; putative nucleoside triphosphate hydrolase domain-containing protein complement(2839246..2839725) Escherichia coli ED1a 7139826 YP_002398800.1 CDS ypfE NC_011745.1 2839738 2840073 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type ps : putative structure; putative carboxysome-like ethanolaminosome structural protein with putative role in ethanol utilization complement(2839738..2840073) Escherichia coli ED1a 7139825 YP_002398801.1 CDS maeB NC_011745.1 2840366 2842645 R NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; malic enzyme complement(2840366..2842645) Escherichia coli ED1a 7140290 YP_002398802.1 CDS talA NC_011745.1 2842934 2843884 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90230300; Product type e : enzyme; transaldolase A 2842934..2843884 Escherichia coli ED1a 7141942 YP_002398803.1 CDS tktB NC_011745.1 2843904 2845907 D catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 2843904..2845907 Escherichia coli ED1a 7141506 YP_002398804.1 CDS ypfG NC_011745.1 2845984 2847027 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2845984..2847027) Escherichia coli ED1a 7141560 YP_002398805.1 CDS yffH NC_011745.1 2847153 2847728 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative NUDIX hydrolase complement(2847153..2847728) Escherichia coli ED1a 7140291 YP_002398806.1 CDS aegA NC_011745.1 2847796 2849775 R unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic); putative oxidoreductase Fe-S binding subunit complement(2847796..2849775) Escherichia coli ED1a 7144033 YP_002398807.1 CDS narQ NC_011745.1 2849981 2851681 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92374842, 1508040, 1528845; Product type r : regulator; nitrate/nitrite sensor protein NarQ 2849981..2851681 Escherichia coli ED1a 7143667 YP_002398808.1 CDS acrD NC_011745.1 2851845 2854958 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12426336, 20158894, 21450803, 79216220, 10692383, 1644752; Product type t : transporter; aminoglycoside/multidrug efflux system 2851845..2854958 Escherichia coli ED1a 7140364 YP_002398809.1 CDS yffB NC_011745.1 2855497 2855853 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2855497..2855853 Escherichia coli ED1a 7143651 YP_002398810.1 CDS dapE NC_011745.1 2855857 2856984 D dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.; succinyl-diaminopimelate desuccinylase 2855857..2856984 Escherichia coli ED1a 7144032 YP_002398811.1 CDS ypfN NC_011745.1 2857012 2857212 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2857012..2857212 Escherichia coli ED1a 7143065 YP_002398812.1 CDS ypfH NC_011745.1 2857293 2857991 R Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase YpfH complement(2857293..2857991) Escherichia coli ED1a 7140295 YP_002398813.1 CDS ypfI NC_011745.1 2858065 2860080 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase complement(2858065..2860080) Escherichia coli ED1a 7140292 YP_002398814.1 CDS ypfJ NC_011745.1 2860095 2860958 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2860095..2860958) Escherichia coli ED1a 7140293 YP_002398815.1 CDS purC NC_011745.1 2861126 2861839 R catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase complement(2861126..2861839) Escherichia coli ED1a 7140294 YP_002398816.1 CDS nlpB NC_011745.1 2862052 2863086 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91358331, 1885529, 2120198; Product type lp : lipoprotein; lipoprotein complement(2862052..2863086) Escherichia coli ED1a 7141215 YP_002398817.1 CDS dapA NC_011745.1 2863103 2863981 R catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase complement(2863103..2863981) Escherichia coli ED1a 7140398 YP_002398818.1 CDS gcvR NC_011745.1 2864127 2864699 D negative transcriptional regulator of the gcvTHP operon; glycine cleavage system transcriptional repressor 2864127..2864699 Escherichia coli ED1a 7143062 YP_002398819.1 CDS bcp NC_011745.1 2864699 2865169 D bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine; thioredoxin-dependent thiol peroxidase 2864699..2865169 Escherichia coli ED1a 7143171 YP_002398820.1 CDS perM NC_011745.1 2865268 2866329 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative permease complement(2865268..2866329) Escherichia coli ED1a 7140433 YP_002398821.1 CDS yfgC NC_011745.1 2866542 2868005 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative peptidase 2866542..2868005 Escherichia coli ED1a 7144066 YP_002398822.1 CDS yfgD NC_011745.1 2868026 2868385 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 2868026..2868385 Escherichia coli ED1a 7143713 YP_002398823.1 CDS hda NC_011745.1 2868523 2869269 R controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP; DNA replication initiation factor complement(2868523..2869269) Escherichia coli ED1a 7143714 YP_002398824.1 CDS uraA NC_011745.1 2869319 2870608 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8332529, 7721693; Product type t : transporter; uracil transporter complement(2869319..2870608) Escherichia coli ED1a 7139858 YP_002398825.1 CDS upp NC_011745.1 2870694 2871320 R Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase complement(2870694..2871320) Escherichia coli ED1a 7139142 YP_002398826.1 CDS purM NC_011745.1 2871645 2872682 D catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 2871645..2872682 Escherichia coli ED1a 7139141 YP_002398827.1 CDS purN NC_011745.1 2872682 2873320 D glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 2872682..2873320 Escherichia coli ED1a 7141222 YP_002398828.1 CDS ppk NC_011745.1 2873492 2875558 D catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase 2873492..2875558 Escherichia coli ED1a 7141223 YP_002398829.1 CDS ppx NC_011745.1 2875563 2877104 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93107072, 94025037, 94165003, 8212131, 8380170; Product type e : enzyme; exopolyphosphatase 2875563..2877104 Escherichia coli ED1a 7139107 YP_002398830.1 CDS yfgF NC_011745.1 2877143 2879386 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(2877143..2879386) Escherichia coli ED1a 7139110 YP_002398831.1 CDS ECED1_2928 NC_011745.1 2879615 2879893 R Evidence 6 : Doubtful CDS; hypothetical protein complement(2879615..2879893) Escherichia coli ED1a 7143715 YP_002398832.1 CDS yfgH NC_011745.1 2880240 2880758 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative outer membrane lipoprotein 2880240..2880758 Escherichia coli ED1a 7143877 YP_002398833.1 CDS yfgI NC_011745.1 2880774 2881313 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2880774..2881313 Escherichia coli ED1a 7143716 YP_002398834.1 CDS guaA NC_011745.1 2881408 2882985 R contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase complement(2881408..2882985) Escherichia coli ED1a 7143717 YP_002398835.1 CDS guaB NC_011745.1 2883054 2884520 R catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase complement(2883054..2884520) Escherichia coli ED1a 7139843 YP_002398836.1 CDS xseA NC_011745.1 2884682 2886058 D bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 2884682..2886058 Escherichia coli ED1a 7139844 YP_002398837.1 CDS ECED1_2934 NC_011745.1 2886127 2886396 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2886127..2886396) Escherichia coli ED1a 7139209 YP_002398838.1 CDS insB NC_011745.1 2886398 2886901 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' complement(2886398..2886901) Escherichia coli ED1a 7143878 YP_002398839.1 CDS insA NC_011745.1 2886820 2887095 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; Transposase ORF A, IS1 complement(2886820..2887095) Escherichia coli ED1a 7141145 YP_002398840.1 CDS ECED1_2939 NC_011745.1 2895001 2895978 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12540539; Product type pm : putative membrane component; putative outer membrane protein (sivI-like) complement(2895001..2895978) Escherichia coli ED1a 7143880 YP_002398841.1 CDS ECED1_2940 NC_011745.1 2896033 2897982 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8500884, 3304658, 12540539; Product type pf : putative factor; putative intimin complement(2896033..2897982) Escherichia coli ED1a 7143881 YP_002398842.1 CDS ECED1_2941 NC_011745.1 2898398 2898613 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2898398..2898613) Escherichia coli ED1a 7143882 YP_002398843.1 CDS engA NC_011745.1 2898676 2900148 R EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA complement(2898676..2900148) Escherichia coli ED1a 7143883 YP_002398844.1 CDS yfgL NC_011745.1 2900266 2901444 R with YaeT, YfiO, and NlpB forms a complex involved in outer membrane protein biogenesis; outer membrane protein assembly complex subunit YfgL complement(2900266..2901444) Escherichia coli ED1a 7143099 YP_002398845.1 CDS yfgM NC_011745.1 2901455 2902075 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2901455..2902075) Escherichia coli ED1a 7143718 YP_002398846.1 CDS hisS NC_011745.1 2902093 2903367 R catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase complement(2902093..2903367) Escherichia coli ED1a 7143719 YP_002398847.1 CDS ispG NC_011745.1 2903478 2904596 R catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase complement(2903478..2904596) Escherichia coli ED1a 7140758 YP_002398848.1 CDS yfgA NC_011745.1 2904623 2905630 R Evidence 4 : Homologs of previously reported genes of unknown function; cytoskeletal protein RodZ complement(2904623..2905630) Escherichia coli ED1a 7142467 YP_002398849.1 CDS yfgB NC_011745.1 2905915 2907069 R 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N complement(2905915..2907069) Escherichia coli ED1a 7143711 YP_002398850.1 CDS ndk NC_011745.1 2907219 2907650 R catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase complement(2907219..2907650) Escherichia coli ED1a 7143712 YP_002398851.1 CDS pbpC NC_011745.1 2907799 2910111 R penicillin-insensitive transglycosylase/transpeptidase; penicillin-binding protein 1C complement(2907799..2910111) Escherichia coli ED1a 7140372 YP_002398852.1 CDS yfhM NC_011745.1 2910112 2915073 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2910112..2915073) Escherichia coli ED1a 7144046 YP_002398853.1 CDS sseA NC_011745.1 2915280 2916125 D catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds; 3-mercaptopyruvate sulfurtransferase 2915280..2916125 Escherichia coli ED1a 7143728 YP_002398854.1 CDS sseB NC_011745.1 2916618 2917394 R enhances serine sensitivity caused by inhibition of homoserine dehydrogenase I; enhanced serine sensitivity protein SseB complement(2916618..2917394) Escherichia coli ED1a 7140760 YP_002398855.1 CDS pepB NC_011745.1 2917536 2918819 R catalyzes the removal of an N-terminal amino acid from a peptide or arylamide; aminopeptidase B complement(2917536..2918819) Escherichia coli ED1a 7143849 YP_002398856.1 CDS yfhJ NC_011745.1 2918878 2919078 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10393315; Product type pf : putative factor; hypothetical protein complement(2918878..2919078) Escherichia coli ED1a 7144059 YP_002398857.1 CDS fdx NC_011745.1 2919090 2919425 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10393315, 20013001, 92283811, 94181532, 11551196, 1317854, 4375562, 8300516; Product type c : carrier; [2Fe-2S] ferredoxin complement(2919090..2919425) Escherichia coli ED1a 7143725 YP_002398858.1 CDS hscA NC_011745.1 2919427 2921277 R involved in the maturation of iron-sulfur cluster-containing proteins; chaperone protein HscA complement(2919427..2921277) Escherichia coli ED1a 7144146 YP_002398859.1 CDS hscB NC_011745.1 2921294 2921809 R J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins; co-chaperone HscB complement(2921294..2921809) Escherichia coli ED1a 7140081 YP_002398860.1 CDS iscA NC_011745.1 2921905 2922228 R forms iron-sulfur clusters of ferredoxin [2FE-2S]; binds iron in the presence of the thioredoxin reductase system; forms homodimers and tetramers; similar to SufA protein; iron-sulfur cluster assembly protein complement(2921905..2922228) Escherichia coli ED1a 7140162 YP_002398861.1 CDS iscU NC_011745.1 2922245 2922631 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10393315, 11994302, 15153099; Product type f : factor; scaffold protein complement(2922245..2922631) Escherichia coli ED1a 7142457 YP_002398862.1 CDS iscS NC_011745.1 2922659 2923873 R catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis; cysteine desulfurase complement(2922659..2923873) Escherichia coli ED1a 7142460 YP_002398863.1 CDS iscR NC_011745.1 2923985 2924473 R regulates the expression of the iscRSUA operon; DNA-binding transcriptional regulator IscR complement(2923985..2924473) Escherichia coli ED1a 7142459 YP_002398864.1 CDS yfhQ NC_011745.1 2924743 2925483 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10393315; Product type pe : putative enzyme; putative methyltransferase complement(2924743..2925483) Escherichia coli ED1a 7142458 YP_002398865.1 CDS suhB NC_011745.1 2925602 2926405 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6389495, 90202735, 95095968, 10747806, 2138605, 8002619; Product type e : enzyme; inositol monophosphatase 2925602..2926405 Escherichia coli ED1a 7143729 YP_002398866.1 CDS yfhR NC_011745.1 2926523 2927404 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative peptidase 2926523..2927404 Escherichia coli ED1a 7141498 YP_002398867.1 CDS csiE NC_011745.1 2927595 2928875 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95020540, 96154950; Product type cp : cell process; stationary phase inducible protein CsiE 2927595..2928875 Escherichia coli ED1a 7143730 YP_002398868.1 CDS hcaT NC_011745.1 2928867 2930006 R putative transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters; putative 3-phenylpropionic acid transporter complement(2928867..2930006) Escherichia coli ED1a 7142067 YP_002398869.1 CDS ECED1_2969 NC_011745.1 2930226 2930378 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2930226..2930378 Escherichia coli ED1a 7139854 YP_002398870.1 CDS yphA NC_011745.1 2930330 2930797 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2930330..2930797 Escherichia coli ED1a 7143884 YP_002398871.1 CDS yphB NC_011745.1 2930957 2931829 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2930957..2931829) Escherichia coli ED1a 7140296 YP_002398872.1 CDS yphC NC_011745.1 2931841 2932902 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase, Zn-dependent and NAD(P)-binding complement(2931841..2932902) Escherichia coli ED1a 7140297 YP_002398873.1 CDS yphD NC_011745.1 2932968 2933966 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter membrane protein complement(2932968..2933966) Escherichia coli ED1a 7140298 YP_002398874.1 CDS yphE NC_011745.1 2933991 2935502 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; fused putative sugar transporter subunits of ABC superfamily: ATP-binding proteins complement(2933991..2935502) Escherichia coli ED1a 7140299 YP_002398875.1 CDS yphF NC_011745.1 2935525 2936508 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9298646; Product type pt : putative transporter; putative sugar ABC transporter periplasmic-binding protein complement(2935525..2936508) Escherichia coli ED1a 7140300 YP_002398876.1 CDS yphG NC_011745.1 2936605 2939886 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2936605..2939886) Escherichia coli ED1a 7140301 YP_002398877.1 CDS yphH NC_011745.1 2940004 2941197 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 2940004..2941197 Escherichia coli ED1a 7140302 YP_002398878.1 CDS glyA NC_011745.1 2941261 2942514 R catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase complement(2941261..2942514) Escherichia coli ED1a 7140303 YP_002398879.1 CDS hmp NC_011745.1 2942843 2944033 D flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine; nitric oxide dioxygenase 2942843..2944033 Escherichia coli ED1a 7142990 YP_002398880.1 CDS glnB NC_011745.1 2944078 2944416 R indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; nitrogen regulatory protein P-II 1 complement(2944078..2944416) Escherichia coli ED1a 7139903 YP_002398881.1 CDS yfhA NC_011745.1 2944477 2945811 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8226691, 8412694; Product type pr : putative regulator; putative DNA-binding response regulator in two-component system complement(2944477..2945811) Escherichia coli ED1a 7143196 YP_002398882.1 CDS yfhG NC_011745.1 2945801 2946514 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2945801..2946514) Escherichia coli ED1a 7143720 YP_002398883.1 CDS yfhK NC_011745.1 2946679 2948106 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative sensory kinase in two-component system complement(2946679..2948106) Escherichia coli ED1a 7143723 YP_002398884.1 CDS purL NC_011745.1 2948682 2952569 R catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase complement(2948682..2952569) Escherichia coli ED1a 7140761 YP_002398885.1 CDS yfhD NC_011745.1 2952965 2954383 D YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function; putative transglycosylase 2952965..2954383 Escherichia coli ED1a 7141221 YP_002398886.1 CDS tadA NC_011745.1 2954380 2954916 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12110595; Product type e : enzyme; tRNA-specific adenosine deaminase complement(2954380..2954916) Escherichia coli ED1a 7143722 YP_002398887.1 CDS yfhB NC_011745.1 2954941 2955576 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2954941..2955576) Escherichia coli ED1a 7141503 YP_002398888.1 CDS yfhH NC_011745.1 2955785 2956633 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 2955785..2956633 Escherichia coli ED1a 7143721 YP_002398889.1 CDS yfhL NC_011745.1 2956689 2956949 D Evidence 2b : Function of strongly homologous gene; PubMedId : 8765743, 8880900; Product type c : carrier; ferredoxin 2956689..2956949 Escherichia coli ED1a 7143724 YP_002398890.1 CDS ECED1_2991 NC_011745.1 2957220 2957384 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2957220..2957384) Escherichia coli ED1a 7140158 YP_002398891.1 CDS acpS NC_011745.1 2957644 2958024 R Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase complement(2957644..2958024) Escherichia coli ED1a 7140159 YP_002398892.1 CDS pdxJ NC_011745.1 2958024 2958755 R involved in the de novo synthesis of pyridoxine (Vitamin B6); pyridoxine 5'-phosphate synthase complement(2958024..2958755) Escherichia coli ED1a 7143647 YP_002398893.1 CDS recO NC_011745.1 2958767 2959495 R involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO complement(2958767..2959495) Escherichia coli ED1a 7144055 YP_002398894.1 CDS era NC_011745.1 2959507 2960412 R Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era complement(2959507..2960412) Escherichia coli ED1a 7141582 YP_002398895.1 CDS rnc NC_011745.1 2960409 2961089 R cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III complement(2960409..2961089) Escherichia coli ED1a 7139809 YP_002398896.1 CDS lepB NC_011745.1 2961361 2962335 R catalyzes the cleavage of the amino-terminal leader peptide from secretory proteins; signal peptidase I complement(2961361..2962335) Escherichia coli ED1a 7141432 YP_002398897.1 CDS lepA NC_011745.1 2962351 2964150 R binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA complement(2962351..2964150) Escherichia coli ED1a 7141874 YP_002398898.1 CDS rseC NC_011745.1 2964348 2964827 R involved in the reduction of the SoxR iron-sulfur cluster; SoxR reducing system protein RseC complement(2964348..2964827) Escherichia coli ED1a 7141873 YP_002398899.1 CDS rseB NC_011745.1 2964824 2965780 R periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP; periplasmic negative regulator of sigmaE complement(2964824..2965780) Escherichia coli ED1a 7140111 YP_002398900.1 CDS rseA NC_011745.1 2965780 2966430 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9159522, 97303092, 99431977, 7768826; Product type f : factor; anti-RNA polymerase sigma factor SigE complement(2965780..2966430) Escherichia coli ED1a 7140110 YP_002398901.1 CDS rpoE NC_011745.1 2966463 2967038 R Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE complement(2966463..2967038) Escherichia coli ED1a 7140109 YP_002398902.1 CDS nadB NC_011745.1 2967446 2969068 D catalyzes the formation of oxaloacetate from L-aspartate; L-aspartate oxidase 2967446..2969068 Escherichia coli ED1a 7141488 YP_002398903.1 CDS yfiC NC_011745.1 2969053 2969790 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative S-adenosyl-L-methionine-dependent methyltransferase complement(2969053..2969790) Escherichia coli ED1a 7140331 YP_002398904.1 CDS srmB NC_011745.1 2969922 2971256 D facilitates an early step in the assembly of the 50S subunit of the ribosome; ATP-dependent RNA helicase SrmB 2969922..2971256 Escherichia coli ED1a 7143733 YP_002398905.1 CDS yfiE NC_011745.1 2971289 2972170 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(2971289..2972170) Escherichia coli ED1a 7143845 YP_002398906.1 CDS yfiK NC_011745.1 2972273 2972860 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12562784; Product type t : transporter; neutral amino-acid efflux protein 2972273..2972860 Escherichia coli ED1a 7143735 YP_002398907.1 CDS yfiD NC_011745.1 2972916 2973299 R stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit; autonomous glycyl radical cofactor GrcA complement(2972916..2973299) Escherichia coli ED1a 7143738 YP_002398908.1 CDS ung NC_011745.1 2973604 2974293 D Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 2973604..2974293 Escherichia coli ED1a 7143734 YP_002398909.1 CDS yfiF NC_011745.1 2974341 2975378 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative methyltransferase complement(2974341..2975378) Escherichia coli ED1a 7139140 YP_002398910.1 CDS ECED1_3013 NC_011745.1 2975368 2975571 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2975368..2975571) Escherichia coli ED1a 7143736 YP_002398911.1 CDS trxC NC_011745.1 2975585 2976004 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12952960, 9388228, 99175138, 10644706; Product type c : carrier; thioredoxin 2 2975585..2976004 Escherichia coli ED1a 7143886 YP_002398912.1 CDS yfiP NC_011745.1 2976073 2976771 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2976073..2976771 Escherichia coli ED1a 7140833 YP_002398913.1 CDS yfiQ NC_011745.1 2976803 2979463 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; fused acyl-CoA synthetase: NAD(P)-binding subunit ; ATP-binding subunit 2976803..2979463 Escherichia coli ED1a 7143743 YP_002398914.1 CDS pssA NC_011745.1 2979577 2980932 D catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome; phosphatidylserine synthase 2979577..2980932 Escherichia coli ED1a 7143744 YP_002398915.1 CDS yfiM NC_011745.1 2981029 2981301 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2981029..2981301 Escherichia coli ED1a 7141196 YP_002398916.1 CDS kgtP NC_011745.1 2981298 2982596 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91219460, 1709493, 2053984, 2118499, 2190187, 8419306; Product type t : transporter; alpha-ketoglutarate transporter complement(2981298..2982596) Escherichia coli ED1a 7143740 YP_002398917.1 CDS insB NC_011745.1 2982758 2983261 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS1 complement(2982758..2983261) Escherichia coli ED1a 7142510 YP_002398918.1 CDS insA NC_011745.1 2983180 2983455 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF 1, IS1 complement(2983180..2983455) Escherichia coli ED1a 7141146 YP_002398919.1 CDS ECED1_3022 NC_011745.1 2983716 2983952 R Evidence 7 : Gene remnant; Product type pe : putative enzyme; hypothetical protein complement(2983716..2983952) Escherichia coli ED1a 7141124 YP_002398920.1 CDS ECED1_3023 NC_011745.1 2984030 2984362 R Evidence 7 : Gene remnant; hypothetical protein complement(2984030..2984362) Escherichia coli ED1a 7143887 YP_002398921.1 CDS ECED1_3024 NC_011745.1 2984278 2984682 R Evidence 7 : Gene remnant; Product type pe : putative enzyme; hypothetical protein complement(2984278..2984682) Escherichia coli ED1a 7143888 YP_002398922.1 CDS ECED1_3025 NC_011745.1 2984926 2985648 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group complement(2984926..2985648) Escherichia coli ED1a 7143889 YP_002398923.1 CDS clpB NC_011745.1 2991853 2994426 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14550559, 14640692, 91294166, 93015925, 93388583, 99428468; Product type f : factor; protein disaggregation chaperone complement(2991853..2994426) Escherichia coli ED1a 7142817 YP_002398924.1 CDS yfiH NC_011745.1 2994556 2995287 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1906060, 2066329; hypothetical protein complement(2994556..2995287) Escherichia coli ED1a 7140160 YP_002398925.1 CDS rluD NC_011745.1 2995284 2996264 R responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase D complement(2995284..2996264) Escherichia coli ED1a 7143737 YP_002398926.1 CDS yfiO NC_011745.1 2996399 2997136 D with YaeT, NlpB and YfgL forms a complex involved in the proper assembly and/or targeting of OMPs to the outer membrane; involved in resistance to ampicillin and tetracycline; outer membrane protein assembly complex subunit YfiO 2996399..2997136 Escherichia coli ED1a 7141427 YP_002398927.1 CDS yfiA NC_011745.1 2997406 2997747 D associated with 30S ribosomal subunit; interferes with translation elongation; translation inhibitor protein RaiA 2997406..2997747 Escherichia coli ED1a 7143742 YP_002398929.1 CDS pheA NC_011745.1 2997997 2999157 D catalyzing the formation of prephenate from chorismate and the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; bifunctional chorismate mutase/prephenate dehydratase 2997997..2999157 Escherichia coli ED1a 7144082 YP_002398930.1 CDS tyrA NC_011745.1 2999200 3000321 R catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis; bifunctional chorismate mutase/prephenate dehydrogenase complement(2999200..3000321) Escherichia coli ED1a 7144081 YP_002398931.1 CDS aroF NC_011745.1 3000332 3001402 R catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase complement(3000332..3001402) Escherichia coli ED1a 7140850 YP_002398932.1 CDS yfiL NC_011745.1 3001613 3001978 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6396419; hypothetical protein 3001613..3001978 Escherichia coli ED1a 7142628 YP_002398933.1 CDS yfiR NC_011745.1 3002127 3002645 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3002127..3002645 Escherichia coli ED1a 7143739 YP_002398934.1 CDS yfiN NC_011745.1 3002635 3003861 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; hypothetical protein 3002635..3003861 Escherichia coli ED1a 7143745 YP_002398935.1 CDS yfiB NC_011745.1 3003877 3004359 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96032391; Product type pm : putative membrane component; putative outer membrane lipoprotein 3003877..3004359 Escherichia coli ED1a 7143741 YP_002398936.1 CDS rplS NC_011745.1 3004436 3004783 R this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 complement(3004436..3004783) Escherichia coli ED1a 7143732 YP_002398937.1 CDS trmD NC_011745.1 3004825 3005592 R methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase complement(3004825..3005592) Escherichia coli ED1a 7141468 YP_002398938.1 CDS rimM NC_011745.1 3005623 3006171 R Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM complement(3005623..3006171) Escherichia coli ED1a 7140815 YP_002398939.1 CDS rpsP NC_011745.1 3006190 3006438 R binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 complement(3006190..3006438) Escherichia coli ED1a 7141420 YP_002398940.1 CDS ffh NC_011745.1 3006575 3007936 R with 4.5S RNA forms a signal recognition particle involved in targeting and integration of inner membrane proteins; signal recognition particle protein complement(3006575..3007936) Escherichia coli ED1a 7140099 YP_002398941.1 CDS ypjD NC_011745.1 3008028 3008894 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3008028..3008894 Escherichia coli ED1a 7144165 YP_002398942.1 CDS yfjD NC_011745.1 3009005 3010201 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3009005..3010201 Escherichia coli ED1a 7140305 YP_002398943.1 CDS grpE NC_011745.1 3010256 3010849 R with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE complement(3010256..3010849) Escherichia coli ED1a 7143747 YP_002398944.1 CDS ppnK NC_011745.1 3010972 3011850 D catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 3010972..3011850 Escherichia coli ED1a 7143023 YP_002398945.1 CDS recN NC_011745.1 3011936 3013597 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87259985, 91355307, 95058623, 3037486; Product type cp : cell process; recombination and repair protein 3011936..3013597 Escherichia coli ED1a 7143746 YP_002398946.1 CDS smpA NC_011745.1 3013746 3014087 D Evidence 2b : Function of strongly homologous gene; PubMedId : 2045357; Product type lp : lipoprotein; hypothetical protein 3013746..3014087 Escherichia coli ED1a 7141581 YP_002398947.1 CDS yfjF NC_011745.1 3014149 3014439 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3014149..3014439) Escherichia coli ED1a 7143811 YP_002398948.1 CDS yfjG NC_011745.1 3014429 3014905 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3014429..3014905) Escherichia coli ED1a 7143748 YP_002398949.1 CDS smpB NC_011745.1 3015037 3015519 D binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 3015037..3015519 Escherichia coli ED1a 7143749 YP_002398950.1 CDS ECED1_3061 NC_011745.1 3016220 3016702 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 3016220..3016702 Escherichia coli ED1a 7143853 YP_002398951.1 CDS D NC_011745.1 3017016 3018116 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; late control gene D protein complement(3017016..3018116) Escherichia coli ED1a 7143892 YP_002398952.1 CDS U NC_011745.1 3018113 3018598 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; bacteriophage tail protein GpU complement(3018113..3018598) Escherichia coli ED1a 7143051 YP_002398953.1 CDS ECED1_3064 NC_011745.1 3018595 3021672 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage tail tape measure protein complement(3018595..3021672) Escherichia coli ED1a 7140855 YP_002398954.1 CDS ECED1_3065 NC_011745.1 3021799 3022101 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage tail protein E complement(3021799..3022101) Escherichia coli ED1a 7143893 YP_002398955.1 CDS fII NC_011745.1 3022156 3022671 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; major tail sheath protein FII complement(3022156..3022671) Escherichia coli ED1a 7143894 YP_002398956.1 CDS fI NC_011745.1 3022681 3023853 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; major tail sheath protein FI complement(3022681..3023853) Escherichia coli ED1a 7144180 YP_002398957.1 CDS pin NC_011745.1 3023996 3024568 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3891522, 3894006, 6310572; Product type h : extrachromosomal origin; site-specific DNA recombinase; e14 prophage complement(3023996..3024568) Escherichia coli ED1a 7144176 YP_002398958.1 CDS ECED1_3069 NC_011745.1 3024590 3025126 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative variable tail fiber protein from prophage (fragment) 3024590..3025126 Escherichia coli ED1a 7139063 YP_002398959.1 CDS tfaE NC_011745.1 3025126 3025728 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative tail fiber chaperone (assembly protein); e14 prophage 3025126..3025728 Escherichia coli ED1a 7143895 YP_002398960.1 CDS ECED1_3071 NC_011745.1 3025700 3026119 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(3025700..3026119) Escherichia coli ED1a 7141536 YP_002398961.1 CDS I NC_011745.1 3027534 3028139 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail protein I (GpI) complement(3027534..3028139) Escherichia coli ED1a 7143897 YP_002398962.1 CDS J NC_011745.1 3028132 3029079 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Baseplate assembly protein GpJ complement(3028132..3029079) Escherichia coli ED1a 7140212 YP_002398963.1 CDS W NC_011745.1 3029027 3029386 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Baseplate assembly protein GpW complement(3029027..3029386) Escherichia coli ED1a 7142483 YP_002398964.1 CDS V NC_011745.1 3029383 3029961 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Baseplate assembly protein GpV complement(3029383..3029961) Escherichia coli ED1a 7139170 YP_002398965.1 CDS ECED1_3077 NC_011745.1 3030030 3030476 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage tail completion protein complement(3030030..3030476) Escherichia coli ED1a 7139163 YP_002398966.1 CDS R NC_011745.1 3030469 3030921 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail completion protein R (GpR) complement(3030469..3030921) Escherichia coli ED1a 7143898 YP_002398967.1 CDS ECED1_3079 NC_011745.1 3030863 3031153 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(3030863..3031153) Escherichia coli ED1a 7141248 YP_002398968.1 CDS ECED1_3080 NC_011745.1 3030996 3031424 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative regulatory protein complement(3030996..3031424) Escherichia coli ED1a 7143899 YP_002398969.1 CDS ECED1_3081 NC_011745.1 3031421 3031870 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(3031421..3031870) Escherichia coli ED1a 7143900 YP_002398970.1 CDS R NC_011745.1 3031800 3032312 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; putative lysozyme protein R of prophage complement(3031800..3032312) Escherichia coli ED1a 7143901 YP_002398971.1 CDS ECED1_3083 NC_011745.1 3032293 3032508 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative secretory protein complement(3032293..3032508) Escherichia coli ED1a 7141249 YP_002398972.1 CDS X NC_011745.1 3032512 3032715 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; phage tail protein X (GpX) complement(3032512..3032715) Escherichia coli ED1a 7143902 YP_002398973.1 CDS L NC_011745.1 3032715 3033242 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; head completion/stabilization protein (GpL) complement(3032715..3033242) Escherichia coli ED1a 7139198 YP_002398974.1 CDS M NC_011745.1 3033275 3033925 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; terminase, endonuclease subunit (GpM) complement(3033275..3033925) Escherichia coli ED1a 7141706 YP_002398975.1 CDS N NC_011745.1 3033929 3034987 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor capsid protein H1 and H2, major capsid protein N* complement(3033929..3034987) Escherichia coli ED1a 7141938 YP_002398976.1 CDS O NC_011745.1 3035004 3035837 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; putative capsid scaffolding protein GpO complement(3035004..3035837) Escherichia coli ED1a 7140328 YP_002398977.1 CDS P NC_011745.1 3035980 3037746 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; terminase, ATPase subunit (GpP) 3035980..3037746 Escherichia coli ED1a 7139963 YP_002398978.1 CDS ECED1_3090 NC_011745.1 3037743 3038780 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage portal protein 3037743..3038780 Escherichia coli ED1a 7139997 YP_002398979.1 CDS ECED1_3091 NC_011745.1 3038818 3039666 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3038818..3039666) Escherichia coli ED1a 7143903 YP_002398980.1 CDS ECED1_3092 NC_011745.1 3039676 3040338 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative repressor protein from prophage complement(3039676..3040338) Escherichia coli ED1a 7143904 YP_002398981.1 CDS ECED1_3093 NC_011745.1 3040358 3041167 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(3040358..3041167) Escherichia coli ED1a 7143905 YP_002398982.1 CDS ECED1_3094 NC_011745.1 3041531 3041836 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative DinI-like damage-inducible protein complement(3041531..3041836) Escherichia coli ED1a 7143906 YP_002398983.1 CDS ECED1_3096 NC_011745.1 3042117 3042473 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(3042117..3042473) Escherichia coli ED1a 7143908 YP_002398984.1 CDS ECED1_3097 NC_011745.1 3042470 3044557 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative bacteriophage replication gene A protein complement(3042470..3044557) Escherichia coli ED1a 7143909 YP_002398985.1 CDS dam NC_011745.1 3044554 3045483 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; site-specific DNA-methyltransferase complement(3044554..3045483) Escherichia coli ED1a 7143910 YP_002398986.1 CDS insB NC_011745.1 3045587 3046090 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS1 complement(3045587..3046090) Escherichia coli ED1a 7143059 YP_002398987.1 CDS insA NC_011745.1 3046009 3046284 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF 1, IS1 complement(3046009..3046284) Escherichia coli ED1a 7141147 YP_002398988.1 CDS ECED1_3102 NC_011745.1 3046335 3046547 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(3046335..3046547) Escherichia coli ED1a 7141125 YP_002398989.1 CDS ECED1_3103 NC_011745.1 3046484 3046711 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative DksA/TraR protein family with a zinc finger complement(3046484..3046711) Escherichia coli ED1a 7143911 YP_002398990.1 CDS ECED1_3104 NC_011745.1 3046711 3046950 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3046711..3046950) Escherichia coli ED1a 7143912 YP_002398991.1 CDS ECED1_3105 NC_011745.1 3047012 3047353 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3047012..3047353) Escherichia coli ED1a 7143913 YP_002398992.1 CDS cII NC_011745.1 3047775 3048284 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; regulatory protein cII complement(3047775..3048284) Escherichia coli ED1a 7143914 YP_002398993.1 CDS ECED1_3107 NC_011745.1 3048317 3048559 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage regulatory protein complement(3048317..3048559) Escherichia coli ED1a 7139357 YP_002398994.1 CDS cI NC_011745.1 3048681 3049313 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; phage regulatory protein cI 3048681..3049313 Escherichia coli ED1a 7143915 YP_002398995.1 CDS int NC_011745.1 3049316 3050332 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Integrase 3049316..3050332 Escherichia coli ED1a 7139355 YP_002398996.1 CDS ECED1_3110 NC_011745.1 3050343 3051011 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3050343..3051011 Escherichia coli ED1a 7141180 YP_002398997.1 CDS ygaT NC_011745.1 3051824 3052801 D in Escherichia coli this gene is induced by carbon starvation and depends on sigma S and cAMP-CRP; the structure of the Gab protein shows it is a member of non-heme iron (II)-dependent oxygenase superfamily which includes clavamini acid synthases; forms homotetramers in solution; hypothetical protein 3051824..3052801 Escherichia coli ED1a 7143916 YP_002398998.1 CDS ygaF NC_011745.1 3052821 3054089 D catalyzed the formation of 2-ketoglutarate from 2-hydroxyglutarate; hydroxyglutarate oxidase 3052821..3054089 Escherichia coli ED1a 7143759 YP_002398999.1 CDS gabD NC_011745.1 3054112 3055560 D catalyzes the formation of succinate from succinate semialdehyde; NADP dependent; succinate-semialdehyde dehydrogenase I 3054112..3055560 Escherichia coli ED1a 7143755 YP_002399000.1 CDS gabT NC_011745.1 3055574 3056854 D catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; 4-aminobutyrate aminotransferase 3055574..3056854 Escherichia coli ED1a 7143138 YP_002399001.1 CDS gabP NC_011745.1 3057091 3058491 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94127927, 9685361, 8297211; Product type t : transporter; gamma-aminobutyrate transporter 3057091..3058491 Escherichia coli ED1a 7143140 YP_002399002.1 CDS csiR NC_011745.1 3058512 3059174 D regulator of gab gene expression; DNA-binding transcriptional regulator CsiR 3058512..3059174 Escherichia coli ED1a 7143139 YP_002399003.1 CDS ygaU NC_011745.1 3059175 3059624 R Evidence 4 : Homologs of previously reported genes of unknown function; LysM domain/BON superfamily protein complement(3059175..3059624) Escherichia coli ED1a 7142068 YP_002399004.1 CDS yqaE NC_011745.1 3059708 3059866 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(3059708..3059866) Escherichia coli ED1a 7143760 YP_002399005.1 CDS ygaV NC_011745.1 3060049 3060348 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3060049..3060348 Escherichia coli ED1a 7140308 YP_002399006.1 CDS ygaP NC_011745.1 3060358 3060882 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pe : putative enzyme; hypothetical protein 3060358..3060882 Escherichia coli ED1a 7143761 YP_002399007.1 CDS stpA NC_011745.1 3060929 3061333 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20485613, 93126121, 9643551, 98132400, 99415935, 1480493, 7961433; Product type r : regulator; DNA binding protein, nucleoid-associated complement(3060929..3061333) Escherichia coli ED1a 7143758 YP_002399008.1 CDS ygaW NC_011745.1 3062000 3062449 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3062000..3062449 Escherichia coli ED1a 7143862 YP_002399009.1 CDS ygaC NC_011745.1 3062486 3062830 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7961433; hypothetical protein complement(3062486..3062830) Escherichia coli ED1a 7143762 YP_002399010.1 CDS ygaM NC_011745.1 3062970 3063311 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3062970..3063311 Escherichia coli ED1a 7143753 YP_002399011.1 CDS ECED1_3126 NC_011745.1 3063368 3064702 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; bifunctional aminotransaminase/GntR family transcriptional regulator complement(3063368..3064702) Escherichia coli ED1a 7143757 YP_002399012.1 CDS ECED1_3127 NC_011745.1 3064790 3065221 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3064790..3065221 Escherichia coli ED1a 7143917 YP_002399013.1 CDS nrdH NC_011745.1 3065429 3065674 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9218434, 11441020, 8820648; Product type pc : putative carrier; glutaredoxin-like protein 3065429..3065674 Escherichia coli ED1a 7143918 YP_002399014.1 CDS nrdI NC_011745.1 3065671 3066081 D in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein 3065671..3066081 Escherichia coli ED1a 7139925 YP_002399015.1 CDS nrdE NC_011745.1 3066054 3068198 D Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 3066054..3068198 Escherichia coli ED1a 7139926 YP_002399016.1 CDS nrdF NC_011745.1 3068208 3069167 D B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 3068208..3069167 Escherichia coli ED1a 7139922 YP_002399017.1 CDS proV NC_011745.1 3069524 3070726 D with ProWX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter ATP-binding subunit 3069524..3070726 Escherichia coli ED1a 7139923 YP_002399018.1 CDS proW NC_011745.1 3070719 3071783 D with ProVX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter membrane protein 3070719..3071783 Escherichia coli ED1a 7139133 YP_002399019.1 CDS proX NC_011745.1 3071840 3072832 D with ProVW, part of the high-affinity transport system for the osmoprotectant glycine betaine; glycine betaine transporter periplasmic subunit 3071840..3072832 Escherichia coli ED1a 7139134 YP_002399020.1 CDS ECED1_3135 NC_011745.1 3073024 3074208 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16000740; Product type pt : putative transporter; putative transport protein (ousB-like) 3073024..3074208 Escherichia coli ED1a 7139135 YP_002399021.1 CDS ygaZ NC_011745.1 3074332 3075069 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 3074332..3075069 Escherichia coli ED1a 7143919 YP_002399022.1 CDS ygaH NC_011745.1 3075059 3075394 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3075059..3075394 Escherichia coli ED1a 7143763 YP_002399023.1 CDS mprA NC_011745.1 3075485 3076015 D DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; negative regulator of the multidrug operon emrAB; transcriptional repressor MprA 3075485..3076015 Escherichia coli ED1a 7143756 YP_002399024.1 CDS emrA NC_011745.1 3076142 3077314 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21450803, 93285984, 94262163, 1409590, 8203018; Product type t : transporter; multidrug efflux system 3076142..3077314 Escherichia coli ED1a 7139017 YP_002399025.1 CDS emrB NC_011745.1 3077331 3078869 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21450803, 93285984, 94262163, 1409590; Product type t : transporter; multidrug efflux system protein 3077331..3078869 Escherichia coli ED1a 7139785 YP_002399026.1 CDS luxS NC_011745.1 3078933 3079448 R catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase complement(3078933..3079448) Escherichia coli ED1a 7139786 YP_002399027.1 CDS gshA NC_011745.1 3079598 3081154 R involved in the first step of glutathione biosynthesis; glutamate--cysteine ligase complement(3079598..3081154) Escherichia coli ED1a 7138981 YP_002399028.1 CDS yqaA NC_011745.1 3081227 3081655 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(3081227..3081655) Escherichia coli ED1a 7143027 YP_002399029.1 CDS yqaB NC_011745.1 3081652 3082218 R YqaB; catalyzes the dephosphorylation of fructose 1-phosphate, 6-phosphogluconate and p-nitrophenyl phosphate (pNPP); presents beta-phosphoglucomutase activity at a lower extent; fructose-1-phosphatase complement(3081652..3082218) Escherichia coli ED1a 7140306 YP_002399030.1 CDS csrA NC_011745.1 3083407 3083592 R affects carbohydrate metabolism; has regulatory role in many processes; carbon storage regulator complement(3083407..3083592) Escherichia coli ED1a 7140613 YP_002399031.1 CDS alaS NC_011745.1 3083827 3086457 R Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase complement(3083827..3086457) Escherichia coli ED1a 7142075 YP_002399032.1 CDS recX NC_011745.1 3086586 3087086 R binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX complement(3086586..3087086) Escherichia coli ED1a 7143685 YP_002399033.1 CDS recA NC_011745.1 3087155 3088216 R catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A complement(3087155..3088216) Escherichia coli ED1a 7141585 YP_002399034.1 CDS ygaD NC_011745.1 3088296 3088793 R Evidence 4 : Homologs of previously reported genes of unknown function; competence damage-inducible protein A complement(3088296..3088793) Escherichia coli ED1a 7141574 YP_002399035.1 CDS mltB NC_011745.1 3088938 3090023 R membrane-bound lytic murein transglycosylase B; catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan; murein hydrolase B complement(3088938..3090023) Escherichia coli ED1a 7143754 YP_002399036.1 CDS srlA NC_011745.1 3090280 3090843 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87194727, 1334233, 3553176; Product type t : transporter; PTS system glucitol/sorbitol-specific transporter subunit IIC 3090280..3090843 Escherichia coli ED1a 7138991 YP_002399037.1 CDS srlE NC_011745.1 3090840 3091799 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1100602, 3553176; Product type t : transporter; PTS system glucitol/sorbitol-specific transporter subunit IIB 3090840..3091799 Escherichia coli ED1a 7143840 YP_002399038.1 CDS srlB NC_011745.1 3091810 3092181 D phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system glucitol/sorbitol-specific transporter subunit IIA 3091810..3092181 Escherichia coli ED1a 7143843 YP_002399039.1 CDS srlD NC_011745.1 3092185 3092964 D catalyzes the conversion of sorbitol 6-phosphate into fructose 6-phosphate; sorbitol-6-phosphate dehydrogenase 3092185..3092964 Escherichia coli ED1a 7143841 YP_002399040.1 CDS gutM NC_011745.1 3093071 3093430 D regulator for glucitol utilization; DNA-binding transcriptional activator GutM 3093071..3093430 Escherichia coli ED1a 7143842 YP_002399041.1 CDS srlR NC_011745.1 3093497 3094270 D regulates genes involved in glucitol utilization; DNA-binding transcriptional repressor SrlR 3093497..3094270 Escherichia coli ED1a 7139850 YP_002399042.1 CDS gutQ NC_011745.1 3094263 3095228 D catalyzes the conversion of D-arabinose 5-phosphate to D-ribulose-5-phosphate; D-arabinose 5-phosphate isomerase 3094263..3095228 Escherichia coli ED1a 7143844 YP_002399043.1 CDS norR NC_011745.1 3095225 3096739 R Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon; anaerobic nitric oxide reductase transcription regulator complement(3095225..3096739) Escherichia coli ED1a 7139851 YP_002399044.1 CDS norV NC_011745.1 3096926 3098365 D detoxifies nitric oxide using NADH; anaerobic nitric oxide reductase flavorubredoxin 3096926..3098365 Escherichia coli ED1a 7140403 YP_002399045.1 CDS norW NC_011745.1 3098362 3099495 D catalyzes the reduction of the rubredoxin moiety of nitric oxide reductase; nitric oxide reductase 3098362..3099495 Escherichia coli ED1a 7140404 YP_002399046.1 CDS hypF NC_011745.1 3099717 3101969 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12377778, 92255260, 8661925; Product type e : enzyme; carbamoyl phosphate phosphatase and maturation protein for [NiFe] hydrogenases complement(3099717..3101969) Escherichia coli ED1a 7140475 YP_002399047.1 CDS hydN NC_011745.1 3102122 3102649 R involved in electron transport from formate to hydrogen; electron transport protein HydN complement(3102122..3102649) Escherichia coli ED1a 7140209 YP_002399048.1 CDS ECED1_3163 NC_011745.1 3102798 3102971 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(3102798..3102971) Escherichia coli ED1a 7140203 YP_002399049.1 CDS ECED1_3164 NC_011745.1 3103077 3103505 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3103077..3103505 Escherichia coli ED1a 7143920 YP_002399050.1 CDS ECED1_3165 NC_011745.1 3103597 3104016 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative HTH-type transcriptional regulator ygjM complement(3103597..3104016) Escherichia coli ED1a 7143921 YP_002399051.1 CDS ECED1_3166 NC_011745.1 3104013 3104324 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3104013..3104324) Escherichia coli ED1a 7143922 YP_002399052.1 CDS ECED1_3167 NC_011745.1 3104487 3105260 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3104487..3105260) Escherichia coli ED1a 7143923 YP_002399053.1 CDS hycI NC_011745.1 3105285 3105755 R involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE; hydrogenase 3 maturation protease complement(3105285..3105755) Escherichia coli ED1a 7143924 YP_002399054.1 CDS hycH NC_011745.1 3105748 3106158 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92215587, 92326636, 1625581, 2187144, 7851435; Product type f : factor; protein required for maturation of hydrogenase 3 complement(3105748..3106158) Escherichia coli ED1a 7140202 YP_002399055.1 CDS hycG NC_011745.1 3106155 3106922 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90251163, 92215587, 92326636, 2187144; Product type e : enzyme; hydrogenase 3 and formate hydrogenase complex subunit HycG complement(3106155..3106922) Escherichia coli ED1a 7140201 YP_002399056.1 CDS hycF NC_011745.1 3106922 3107464 R electron transfer protein for hydrogenase-3; the formate hydrogenlyase complex comprises of a formate dehydrogenase, unidentified electron carriers and hydrogenase-3; in this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate; formate hydrogenlyase complex iron-sulfur subunit complement(3106922..3107464) Escherichia coli ED1a 7140200 YP_002399057.1 CDS hycE NC_011745.1 3107474 3109183 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92215587, 92326636, 94170785, 2187144, 8125094; Product type e : enzyme; hydrogenase 3, large subunit complement(3107474..3109183) Escherichia coli ED1a 7140199 YP_002399058.1 CDS hycD NC_011745.1 3109201 3110124 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90251163, 92215587, 92326636; Product type m : membrane component; hydrogenase 3, membrane subunit complement(3109201..3110124) Escherichia coli ED1a 7140198 YP_002399059.1 CDS hycC NC_011745.1 3110127 3111953 R catalyzes the oxidation of formate to carbon dioxide and molecular hydrogen; formate hydrogenlyase comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (subunit 3); formate hydrogenlyase subunit 3 complement(3110127..3111953) Escherichia coli ED1a 7140197 YP_002399060.1 CDS hycB NC_011745.1 3111950 3112561 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90251163, 92215587, 92326636, 2187144; Product type c : carrier; hydrogenase 3, Fe-S subunit complement(3111950..3112561) Escherichia coli ED1a 7140196 YP_002399061.1 CDS hycA NC_011745.1 3112686 3113147 R regulates several genes involved in the formate hydrogenlyase system; seems to prevent binding of FhlA transcriptional activator to the activator sequence of hyc operon; formate hydrogenlyase regulatory protein HycA complement(3112686..3113147) Escherichia coli ED1a 7140195 YP_002399062.1 CDS hypA NC_011745.1 3113359 3113709 D plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein 3113359..3113709 Escherichia coli ED1a 7140194 YP_002399063.1 CDS hypB NC_011745.1 3113713 3114585 D GTP hydrolase involved in nickel liganding into hydrogenases; hydrogenase nickel incorporation protein HypB 3113713..3114585 Escherichia coli ED1a 7140204 YP_002399064.1 CDS hypC NC_011745.1 3114576 3114848 D HypC; accessory protein necessary for maturation of the hydrogenase isoforms 1, 2 and 3; forms a complex with HypD, HypE, and HypF proteins, which is the site of ligand biosynthesis and attachment to the iron atom of the NiFe site in the hydrogenase; hydrogenase assembly chaperone 3114576..3114848 Escherichia coli ED1a 7140205 YP_002399065.1 CDS hypD NC_011745.1 3114848 3115969 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91194542, 92255260, 1849603; Product type f : factor; protein required for maturation of hydrogenases 3114848..3115969 Escherichia coli ED1a 7140206 YP_002399066.1 CDS hypE NC_011745.1 3116008 3116976 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91194542, 9485446, 1849603; Product type e : enzyme; carbamoyl phosphate phosphatase, hydrogenase 3 maturation protein 3116008..3116976 Escherichia coli ED1a 7140207 YP_002399067.1 CDS fhlA NC_011745.1 3117050 3119128 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20307603, 21557168, 90368529, 92140045, 94018617, 2118503, 2280686; Product type r : regulator; DNA-binding transcriptional activator 3117050..3119128 Escherichia coli ED1a 7140208 YP_002399068.1 CDS ECED1_3184 NC_011745.1 3119134 3119601 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative molybdenum-pterin-binding-protein 3119134..3119601 Escherichia coli ED1a 7144168 YP_002399069.1 CDS ygbA NC_011745.1 3119640 3119984 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3119640..3119984) Escherichia coli ED1a 7143925 YP_002399070.1 CDS mutS NC_011745.1 3120270 3122831 D This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 3120270..3122831 Escherichia coli ED1a 7143764 YP_002399071.1 CDS pphB NC_011745.1 3122937 3123593 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9130712; Product type e : enzyme; serine/threonine-specific protein phosphatase 2 3122937..3123593 Escherichia coli ED1a 7139057 YP_002399072.1 CDS ygbI NC_011745.1 3123644 3124441 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(3123644..3124441) Escherichia coli ED1a 7139102 YP_002399073.1 CDS ygbJ NC_011745.1 3124607 3125515 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative NAD(P)-binding Rossmann-fold domain-containing dehydrogenase 3124607..3125515 Escherichia coli ED1a 7143766 YP_002399074.1 CDS ygbK NC_011745.1 3125512 3126774 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11520622; hypothetical protein 3125512..3126774 Escherichia coli ED1a 7143767 YP_002399075.1 CDS ygbL NC_011745.1 3126771 3127409 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative aldolase 3126771..3127409 Escherichia coli ED1a 7143768 YP_002399076.1 CDS ygbM NC_011745.1 3127414 3128190 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3127414..3128190 Escherichia coli ED1a 7143769 YP_002399077.1 CDS ygbN NC_011745.1 3128279 3129643 D member of the Gnt family of gluconate transporters; not involved in gluconate transport; unknown function; inner membrane permease YgbN 3128279..3129643 Escherichia coli ED1a 7143770 YP_002399078.1 CDS ECED1_3194 NC_011745.1 3129786 3130829 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative exported Zn-dependent hydrolase complement(3129786..3130829) Escherichia coli ED1a 7143771 YP_002399079.1 CDS ECED1_3195 NC_011745.1 3131054 3131605 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9694845; Product type pf : putative factor; hypothetical protein 3131054..3131605 Escherichia coli ED1a 7143926 YP_002399080.1 CDS rpoS NC_011745.1 3131776 3132768 R sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor controls a regulon of genes required for protection against external stresses; RNA polymerase sigma factor RpoS complement(3131776..3132768) Escherichia coli ED1a 7143927 YP_002399081.1 CDS nlpD NC_011745.1 3132831 3133970 R outer membrane lipoprotein involved in stationary-phase cell survival; similar to LppB virulence determinant from Haemophilus somnus; lipoprotein NlpD complement(3132831..3133970) Escherichia coli ED1a 7139757 YP_002399082.1 CDS pcm NC_011745.1 3134110 3134736 R catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins; protein-L-isoaspartate O-methyltransferase complement(3134110..3134736) Escherichia coli ED1a 7140400 YP_002399083.1 CDS surE NC_011745.1 3134730 3135491 R catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate; stationary phase survival protein SurE complement(3134730..3135491) Escherichia coli ED1a 7144049 YP_002399084.1 CDS truD NC_011745.1 3135472 3136521 R catalyzes the modification of U13 in tRNA(Glu); tRNA pseudouridine synthase D complement(3135472..3136521) Escherichia coli ED1a 7141501 YP_002399085.1 CDS ispF NC_011745.1 3136518 3136997 R catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase complement(3136518..3136997) Escherichia coli ED1a 7140830 YP_002399086.1 CDS ispD NC_011745.1 3136997 3137707 R 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase complement(3136997..3137707) Escherichia coli ED1a 7142466 YP_002399087.1 CDS ftsB NC_011745.1 3137726 3138037 R forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein; cell division protein FtsB complement(3137726..3138037) Escherichia coli ED1a 7142464 YP_002399088.1 CDS ygbE NC_011745.1 3138230 3138553 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(3138230..3138553) Escherichia coli ED1a 7142189 YP_002399089.1 CDS cysC NC_011745.1 3138603 3139208 R converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis; adenylylsulfate kinase complement(3138603..3139208) Escherichia coli ED1a 7143765 YP_002399090.1 CDS cysN NC_011745.1 3139208 3140635 R may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ; sulfate adenylyltransferase subunit 1 complement(3139208..3140635) Escherichia coli ED1a 7142109 YP_002399091.1 CDS cysD NC_011745.1 3140637 3141545 R with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; sulfate adenylyltransferase subunit 2 complement(3140637..3141545) Escherichia coli ED1a 7143042 YP_002399092.1 CDS iap NC_011745.1 3141797 3142834 D catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3; alkaline phosphatase isozyme conversion aminopeptidase 3141797..3142834 Escherichia coli ED1a 7142110 YP_002399093.1 CDS ECED1_3210 NC_011745.1 3142959 3143111 R Evidence 1b : Function experimentally demonstrated in the studied species; Product type pm : putative membrane component; small toxic peptide complement(3142959..3143111) Escherichia coli ED1a 7140214 YP_002399094.1 CDS cysH NC_011745.1 3143376 3144110 R catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite; phosphoadenosine phosphosulfate reductase complement(3143376..3144110) Escherichia coli ED1a 7143928 YP_002399095.1 CDS cysI NC_011745.1 3144184 3145896 R hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide; sulfite reductase subunit beta complement(3144184..3145896) Escherichia coli ED1a 7143037 YP_002399096.1 CDS cysJ NC_011745.1 3145896 3147695 R catalyzes the reduction of sulfite to sulfide in the biosynthesis of L-cysteine from sulfate; a flavoprotein with flavin reductase activity; sulfite reductase subunit alpha complement(3145896..3147695) Escherichia coli ED1a 7143038 YP_002399097.1 CDS ygcM NC_011745.1 3148011 3148376 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12123838; Product type e : enzyme; 6-pyruvoyl tetrahydrobiopterin synthase 3148011..3148376 Escherichia coli ED1a 7143039 YP_002399098.1 CDS ygcN NC_011745.1 3148454 3149725 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase with FAD/NAD(P)-binding domain 3148454..3149725 Escherichia coli ED1a 7143775 YP_002399099.1 CDS ygcO NC_011745.1 3149716 3149976 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative 4Fe-4S cluster-containing protein 3149716..3149976 Escherichia coli ED1a 7143776 YP_002399100.1 CDS ygcP NC_011745.1 3149993 3150568 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative anti-terminator regulatory protein 3149993..3150568 Escherichia coli ED1a 7143777 YP_002399101.1 CDS ygcQ NC_011745.1 3150716 3151576 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative flavoprotein complement(3150716..3151576) Escherichia coli ED1a 7143778 YP_002399102.1 CDS ygcR NC_011745.1 3151573 3152355 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative flavoprotein complement(3151573..3152355) Escherichia coli ED1a 7143779 YP_002399103.1 CDS ygcS NC_011745.1 3152327 3153664 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter complement(3152327..3153664) Escherichia coli ED1a 7143780 YP_002399104.1 CDS ygcU NC_011745.1 3153758 3155212 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative FAD containing dehydrogenase complement(3153758..3155212) Escherichia coli ED1a 7143781 YP_002399105.1 CDS ygcW NC_011745.1 3155282 3156067 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative deoxygluconate dehydrogenase complement(3155282..3156067) Escherichia coli ED1a 7143782 YP_002399106.1 CDS yqcE NC_011745.1 3156386 3157663 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 3156386..3157663 Escherichia coli ED1a 7143783 YP_002399107.1 CDS ygcE NC_011745.1 3157690 3159168 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative kinase 3157690..3159168 Escherichia coli ED1a 7140311 YP_002399108.1 CDS ygcF NC_011745.1 3159581 3160252 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3159581..3160252) Escherichia coli ED1a 7143772 YP_002399109.1 CDS ECED1_3226 NC_011745.1 3160425 3161027 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3160425..3161027 Escherichia coli ED1a 7143773 YP_002399110.1 CDS ygcG NC_011745.1 3161011 3161934 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3161011..3161934 Escherichia coli ED1a 7143929 YP_002399111.1 CDS ECED1_3228 NC_011745.1 3161949 3163097 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3161949..3163097 Escherichia coli ED1a 7143774 YP_002399112.1 CDS ECED1_3230 NC_011745.1 3163091 3163975 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3163091..3163975 Escherichia coli ED1a 7143930 YP_002399113.1 CDS ECED1_3231 NC_011745.1 3163785 3164051 D Evidence 6 : Doubtful CDS; hypothetical protein 3163785..3164051 Escherichia coli ED1a 7143931 YP_002399114.1 CDS eno NC_011745.1 3164035 3165333 R enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase complement(3164035..3165333) Escherichia coli ED1a 7143932 YP_002399115.1 CDS pyrG NC_011745.1 3165421 3167058 R CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase complement(3165421..3167058) Escherichia coli ED1a 7139793 YP_002399116.1 CDS mazG NC_011745.1 3167286 3168077 R functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era; nucleoside triphosphate pyrophosphohydrolase complement(3167286..3168077) Escherichia coli ED1a 7141236 YP_002399117.1 CDS chpA NC_011745.1 3168149 3168484 R MazF; endoribonuclease; toxin of the ChpA-ChpR toxin-antitoxin system; toxin ChpA complement(3168149..3168484) Escherichia coli ED1a 7142216 YP_002399118.1 CDS chpR NC_011745.1 3168484 3168732 R part of the MazF-MazE toxin-antitoxin system; conteracts MazF; antitoxin MazE complement(3168484..3168732) Escherichia coli ED1a 7139345 YP_002399119.1 CDS relA NC_011745.1 3168810 3171044 R (p)ppGpp synthetase; catalyzes the formation of pppGpp and ppGpp from ATP and GTP or GDP; GDP/GTP pyrophosphokinase complement(3168810..3171044) Escherichia coli ED1a 7139346 YP_002399120.1 CDS rumA NC_011745.1 3171092 3172393 R in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]; 23S rRNA 5-methyluridine methyltransferase complement(3171092..3172393) Escherichia coli ED1a 7141586 YP_002399121.1 CDS barA NC_011745.1 3172450 3175206 D part of the two-component regulatory system with UvrY; involved in the regulation of carbon metabolism via the csrA/csrB regulatory system; hybrid sensory histidine kinase BarA 3172450..3175206 Escherichia coli ED1a 7140135 YP_002399122.1 CDS gudD NC_011745.1 3175437 3176777 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20233700, 9772162, 10762278, 13971911; Product type e : enzyme; (D)-glucarate dehydratase 1 complement(3175437..3176777) Escherichia coli ED1a 7140429 YP_002399123.1 CDS gudX NC_011745.1 3176798 3178138 R Evidence 2b : Function of strongly homologous gene; PubMedId : 9772162; Product type e : enzyme; glucarate dehydratase complement(3176798..3178138) Escherichia coli ED1a 7139847 YP_002399124.1 CDS gudP NC_011745.1 3178140 3179492 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10762278; Product type pt : putative transporter; putative D-glucarate transporter complement(3178140..3179492) Escherichia coli ED1a 7139849 YP_002399125.1 CDS yqcA NC_011745.1 3179926 3180375 R An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin complement(3179926..3180375) Escherichia coli ED1a 7139848 YP_002399126.1 CDS truC NC_011745.1 3180393 3181175 R catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp; tRNA pseudouridine synthase C complement(3180393..3181175) Escherichia coli ED1a 7140309 YP_002399127.1 CDS yqcC NC_011745.1 3181175 3181504 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3181175..3181504) Escherichia coli ED1a 7140829 YP_002399128.1 CDS syd NC_011745.1 3182126 3182671 R putative SecY regulator that either chelates excess SecY or negatively regulates the SecYE translocase function; SecY interacting protein Syd complement(3182126..3182671) Escherichia coli ED1a 7142076 YP_002399129.1 CDS queF NC_011745.1 3182739 3183587 D catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 3182739..3183587 Escherichia coli ED1a 7141502 YP_002399130.1 CDS ygdH NC_011745.1 3183699 3185063 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3183699..3185063 Escherichia coli ED1a 7141246 YP_002399131.1 CDS sdaC NC_011745.1 3185620 3186909 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8752353, 8026499; Product type pt : putative transporter; putative serine transporter 3185620..3186909 Escherichia coli ED1a 7143787 YP_002399132.1 CDS sdaB NC_011745.1 3186967 3188334 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91193203, 93215657, 8385012; Product type e : enzyme; L-serine deaminase II 3186967..3188334 Escherichia coli ED1a 7141379 YP_002399133.1 CDS xni NC_011745.1 3188356 3189201 D has 3'-5' exonuclease activity that preferentially acts on ssDNA; also 3'-phosphodiesterase activity at sites with 3' incised apurinic/apyrimidinic sites; can remove 3' phosphoglycolate groups; exonuclease IX 3188356..3189201 Escherichia coli ED1a 7141378 YP_002399134.1 CDS fucO NC_011745.1 3189306 3190457 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88142551, 89291720, 2553671, 2661535, 2664711, 8385012; Product type e : enzyme; L-1,2-propanediol oxidoreductase complement(3189306..3190457) Escherichia coli ED1a 7139832 YP_002399135.1 CDS fucA NC_011745.1 3190482 3191129 R catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase complement(3190482..3191129) Escherichia coli ED1a 7143127 YP_002399136.1 CDS fucP NC_011745.1 3191676 3192992 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88142551, 90036697, 2553671, 2664711, 7783647; Product type t : transporter; L-fucose transporter 3191676..3192992 Escherichia coli ED1a 7143124 YP_002399137.1 CDS fucI NC_011745.1 3193025 3194800 D catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose; L-fucose isomerase 3193025..3194800 Escherichia coli ED1a 7143128 YP_002399138.1 CDS fucK NC_011745.1 3194879 3196327 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88142551, 90036697, 2664711, 13905785; Product type e : enzyme; L-fuculokinase 3194879..3196327 Escherichia coli ED1a 7143125 YP_002399139.1 CDS fucU NC_011745.1 3196329 3196751 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15060078, 12738765, 80049526, 2664711; Product type e : enzyme; L-fucose mutarotase 3196329..3196751 Escherichia coli ED1a 7143126 YP_002399140.1 CDS fucR NC_011745.1 3196809 3197540 D regulates expression of genes involved in L-fucose utilization; DNA-binding transcriptional activator FucR 3196809..3197540 Escherichia coli ED1a 7143130 YP_002399141.1 CDS ygdE NC_011745.1 3197584 3198684 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 21188420, 7704273; Product type pe : putative enzyme; putative RNA 2'-O-ribose methyltransferase complement(3197584..3198684) Escherichia coli ED1a 7143129 YP_002399142.1 CDS ygdD NC_011745.1 3198677 3199072 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7704273; Product type pm : putative membrane component; hypothetical protein complement(3198677..3199072) Escherichia coli ED1a 7143786 YP_002399143.1 CDS gcvA NC_011745.1 3199091 3200008 R Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence; DNA-binding transcriptional activator GcvA complement(3199091..3200008) Escherichia coli ED1a 7143785 YP_002399144.1 CDS ECED1_3262 NC_011745.1 3200326 3200619 D Evidence 6 : Doubtful CDS; hypothetical protein 3200326..3200619 Escherichia coli ED1a 7143168 YP_002399145.1 CDS ygdI NC_011745.1 3200359 3200586 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3200359..3200586) Escherichia coli ED1a 7143933 YP_002399146.1 CDS csdA NC_011745.1 3200778 3201983 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15148362, 9278392, 10739946, 10829016; Product type e : enzyme; cysteine sulfinate desulfinase 3200778..3201983 Escherichia coli ED1a 7143788 YP_002399147.1 CDS ygdK NC_011745.1 3201983 3202426 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative Fe-S metabolism protein (sufE-like) 3201983..3202426 Escherichia coli ED1a 7142059 YP_002399148.1 CDS ygdL NC_011745.1 3202477 3203283 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3202477..3203283) Escherichia coli ED1a 7143789 YP_002399149.1 CDS mltA NC_011745.1 3203360 3204457 R membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase A complement(3203360..3204457) Escherichia coli ED1a 7143790 YP_002399150.1 CDS ECED1_3268 NC_011745.1 3205042 3205998 R Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; 2-hydroxyacid dehydrogenase complement(3205042..3205998) Escherichia coli ED1a 7140576 YP_002399151.1 CDS ECED1_3269 NC_011745.1 3206061 3206657 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphosugar isomerase complement(3206061..3206657) Escherichia coli ED1a 7143934 YP_002399152.1 CDS ECED1_3270 NC_011745.1 3206660 3207835 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative aminotransferase complement(3206660..3207835) Escherichia coli ED1a 7143935 YP_002399153.1 CDS ECED1_3271 NC_011745.1 3207835 3209415 R Evidence 2b : Function of strongly homologous gene; Product type t : transporter; PTS system maltose and glucose-specific transporter subunit IIABC complement(3207835..3209415) Escherichia coli ED1a 7143936 YP_002399154.1 CDS ECED1_3272 NC_011745.1 3209447 3210328 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcription antiterminator complement(3209447..3210328) Escherichia coli ED1a 7143937 YP_002399155.1 CDS amiC NC_011745.1 3210529 3211782 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12787347, 21348478; Product type e : enzyme; N-acetylmuramoyl-L-alanine amidase complement(3210529..3211782) Escherichia coli ED1a 7143938 YP_002399156.1 CDS argA NC_011745.1 3212014 3213345 D catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; N-acetylglutamate synthase 3212014..3213345 Escherichia coli ED1a 7143704 YP_002399157.1 CDS recD NC_011745.1 3213407 3215233 R helicase/nuclease; with RecBC catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit alpha complement(3213407..3215233) Escherichia coli ED1a 7142609 YP_002399158.1 CDS recB NC_011745.1 3215233 3218775 R helicase/nuclease; with RecCD catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit beta complement(3215233..3218775) Escherichia coli ED1a 7141577 YP_002399159.1 CDS ptr NC_011745.1 3218768 3221656 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91193232, 1570301, 3308636, 3534791, 3537960, 8099278; Product type e : enzyme; protease III complement(3218768..3221656) Escherichia coli ED1a 7141575 YP_002399160.1 CDS recC NC_011745.1 3221832 3225200 R catalyzes ATP-dependent exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides; component of the RecBCD (Exo V) helicase/nuclease complex that is essential for recombination; exonuclease V subunit gamma complement(3221832..3225200) Escherichia coli ED1a 7141203 YP_002399161.1 CDS ppdC NC_011745.1 3225213 3225536 R Evidence 2b : Function of strongly homologous gene; PubMedId : 7934814; Product type e : enzyme; hypothetical protein complement(3225213..3225536) Escherichia coli ED1a 7141576 YP_002399162.1 CDS ygdB NC_011745.1 3225521 3225928 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3225521..3225928) Escherichia coli ED1a 7139099 YP_002399163.1 CDS ppdB NC_011745.1 3225925 3226488 R Evidence 2b : Function of strongly homologous gene; PubMedId : 7934814; Product type e : enzyme; hypothetical protein complement(3225925..3226488) Escherichia coli ED1a 7143784 YP_002399164.1 CDS ppdA NC_011745.1 3226479 3226949 R Evidence 2b : Function of strongly homologous gene; PubMedId : 7934814; Product type e : enzyme; hypothetical protein complement(3226479..3226949) Escherichia coli ED1a 7139098 YP_002399165.1 CDS thyA NC_011745.1 3227134 3227928 R ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase complement(3227134..3227928) Escherichia coli ED1a 7139097 YP_002399166.1 CDS lgt NC_011745.1 3227935 3228810 R transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase complement(3227935..3228810) Escherichia coli ED1a 7141555 YP_002399167.1 CDS ptsP NC_011745.1 3228961 3231207 R member of a second PTS chain involved in nitrogen metabolism; PtsP phosphorylates NPr; fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain complement(3228961..3231207) Escherichia coli ED1a 7141884 YP_002399168.1 CDS nudH NC_011745.1 3231220 3231750 R hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase complement(3231220..3231750) Escherichia coli ED1a 7141212 YP_002399169.1 CDS mutH NC_011745.1 3232435 3233124 D MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair; DNA mismatch repair protein 3232435..3233124 Escherichia coli ED1a 7139943 YP_002399170.1 CDS ygdQ NC_011745.1 3233193 3233906 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3233193..3233906 Escherichia coli ED1a 7139054 YP_002399171.1 CDS ygdR NC_011745.1 3234044 3234262 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3234044..3234262 Escherichia coli ED1a 7139465 YP_002399172.1 CDS tas NC_011745.1 3234370 3235410 D complements the prephenate dehydrogenase dysfunction of an Escherichia coli tyrosine auxotroph strain; member of the aldo/keto reductase 2 family; crystal structure of purified Escherichia coli protein shows bound NADPH; putative aldo-keto reductase 3234370..3235410 Escherichia coli ED1a 7139594 YP_002399173.1 CDS ygeD NC_011745.1 3235442 3236635 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8300626; Product type pm : putative membrane component; lysophospholipid transporter LplT complement(3235442..3236635) Escherichia coli ED1a 7141511 YP_002399174.1 CDS aas NC_011745.1 3236628 3238787 R Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase complement(3236628..3238787) Escherichia coli ED1a 7139596 YP_002399175.1 CDS galR NC_011745.1 3239373 3240404 D controls transcription of galETKM; DNA-binding transcriptional regulator GalR 3239373..3240404 Escherichia coli ED1a 7139979 YP_002399176.1 CDS lysA NC_011745.1 3240411 3241673 R catalyzes the decarboxylation of diaminopimelate into lysine; pyridoxal phosphate(PLP)-binding; diaminopimelate decarboxylase complement(3240411..3241673) Escherichia coli ED1a 7143153 YP_002399177.1 CDS lysR NC_011745.1 3241795 3242730 D activates the transcription of the lysA gene encoding diaminopimelate decarboxylase; DNA-binding transcriptional regulator LysR 3241795..3242730 Escherichia coli ED1a 7141931 YP_002399178.1 CDS ygeA NC_011745.1 3242717 3243409 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15135544; Product type pe : putative enzyme; putative racemase complement(3242717..3243409) Escherichia coli ED1a 7141934 YP_002399179.1 CDS araE NC_011745.1 3243538 3244956 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7030324, 90239116, 91154204, 2836407, 3543693, 6319708; Product type t : transporter; arabinose transporter complement(3243538..3244956) Escherichia coli ED1a 7139595 YP_002399180.1 CDS kduD NC_011745.1 3245294 3246055 R catalyzes the formation of 3-dehydro-2-deoxy-D-gluconate from 2-deoxy-D-gluconate; 2-deoxy-D-gluconate 3-dehydrogenase complement(3245294..3246055) Escherichia coli ED1a 7142600 YP_002399181.1 CDS kduI NC_011745.1 3246085 3246921 R 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate; 5-keto-4-deoxyuronate isomerase complement(3246085..3246921) Escherichia coli ED1a 7142503 YP_002399182.1 CDS yqeF NC_011745.1 3247208 3248389 R Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis; acetyl-CoA acetyltransferase complement(3247208..3248389) Escherichia coli ED1a 7142504 YP_002399183.1 CDS yqeG NC_011745.1 3248644 3249804 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 3248644..3249804 Escherichia coli ED1a 7140315 YP_002399184.1 CDS Q NC_011745.1 3250881 3251273 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Antitermination protein Q from prophage complement(3250881..3251273) Escherichia coli ED1a 7140316 YP_002399185.1 CDS ECED1_3304 NC_011745.1 3251464 3251631 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(3251464..3251631) Escherichia coli ED1a 7141240 YP_002399186.1 CDS ECED1_3305 NC_011745.1 3251789 3252256 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3251789..3252256) Escherichia coli ED1a 7143939 YP_002399187.1 CDS yjhC NC_011745.1 3252837 3253940 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase; KpLE2 phage-like element complement(3252837..3253940) Escherichia coli ED1a 7143940 YP_002399188.1 CDS yjhB NC_011745.1 3253953 3255170 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sialic acid transporter complement(3253953..3255170) Escherichia coli ED1a 7139575 YP_002399189.1 CDS ECED1_3309 NC_011745.1 3255918 3256358 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative single-stranded DNA-binding protein (SSB) (Helix-destabilizing protein) complement(3255918..3256358) Escherichia coli ED1a 7139574 YP_002399190.1 CDS ECED1_3310 NC_011745.1 3256355 3256804 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(3256355..3256804) Escherichia coli ED1a 7143941 YP_002399191.1 CDS ECED1_3311 NC_011745.1 3257092 3258912 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative DNA primase from prophage complement(3257092..3258912) Escherichia coli ED1a 7143942 YP_002399192.1 CDS ECED1_3312 NC_011745.1 3258909 3259202 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3258909..3259202) Escherichia coli ED1a 7143943 YP_002399193.1 CDS ECED1_3313 NC_011745.1 3259260 3259463 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3259260..3259463) Escherichia coli ED1a 7143944 YP_002399194.1 CDS ECED1_3314 NC_011745.1 3259641 3260939 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3259641..3260939) Escherichia coli ED1a 7143945 YP_002399195.1 CDS ECED1_3316 NC_011745.1 3260557 3260835 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3260557..3260835 Escherichia coli ED1a 7143946 YP_002399196.1 CDS ECED1_3317 NC_011745.1 3260936 3261154 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(3260936..3261154) Escherichia coli ED1a 7143947 YP_002399197.1 CDS ECED1_3318 NC_011745.1 3261141 3261878 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3261141..3261878) Escherichia coli ED1a 7143948 YP_002399198.1 CDS ECED1_3319 NC_011745.1 3261871 3262386 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(3261871..3262386) Escherichia coli ED1a 7143949 YP_002399199.1 CDS ECED1_3320 NC_011745.1 3262451 3262654 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative regulatory protein from prophage (AlpA family) complement(3262451..3262654) Escherichia coli ED1a 7143950 YP_002399200.1 CDS ECED1_3322 NC_011745.1 3262917 3263084 D Evidence 6 : Doubtful CDS; hypothetical protein 3262917..3263084 Escherichia coli ED1a 7143951 YP_002399201.1 CDS ECED1_3323 NC_011745.1 3263062 3263235 D Evidence 6 : Doubtful CDS; hypothetical protein 3263062..3263235 Escherichia coli ED1a 7143952 YP_002399202.1 CDS int NC_011745.1 3263297 3264550 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Integrase from prophage complement(3263297..3264550) Escherichia coli ED1a 7142872 YP_002399203.1 CDS ygeR NC_011745.1 3264828 3265583 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15150243; Product type r : regulator; Tetratricopeptide repeat transcriptional regulator complement(3264828..3265583) Escherichia coli ED1a 7140612 YP_002399204.1 CDS xdhA NC_011745.1 3266036 3268294 D putative molybdenum cofactor-binding protein; participates in purine salvage; xanthine dehydrogenase subunit XdhA 3266036..3268294 Escherichia coli ED1a 7139597 YP_002399205.1 CDS xdhB NC_011745.1 3268305 3269183 D FAD-binding subunit; with XdhA and XdhC participates in purine salvage; xanthine dehydrogenase subunit XdhB 3268305..3269183 Escherichia coli ED1a 7139202 YP_002399206.1 CDS xdhC NC_011745.1 3269180 3269659 D iron-sulfur-binding subunit; with XdhA and XdhB participates in purine salvage; xanthine dehydrogenase subunit XdhC 3269180..3269659 Escherichia coli ED1a 7139203 YP_002399207.1 CDS ygeV NC_011745.1 3269699 3271477 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(3269699..3271477) Escherichia coli ED1a 7139204 YP_002399208.1 CDS ygeW NC_011745.1 3271953 3273143 D Evidence 4 : Homologs of previously reported genes of unknown function; aspartate/ornithine carbamoyltransferase family protein 3271953..3273143 Escherichia coli ED1a 7139598 YP_002399209.1 CDS ygeX NC_011745.1 3273201 3274397 D catalyzes the formation of pyruvate from 2,3-diaminopropionate; diaminopropionate ammonia-lyase 3273201..3274397 Escherichia coli ED1a 7139599 YP_002399210.1 CDS ygeY NC_011745.1 3274455 3275666 D Zn-dependent extracellular dipeptidase; similar to succinyl-diaminopimelate desuccinylases; peptidase 3274455..3275666 Escherichia coli ED1a 7139600 YP_002399211.1 CDS hyuA NC_011745.1 3275720 3277105 D catalyzes the hydrolytic cleavage of hydantoin with aromatic side chains at the 5'position; phenylhydantoinase 3275720..3277105 Escherichia coli ED1a 7139601 YP_002399212.1 CDS yqeA NC_011745.1 3277153 3278085 D catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 3277153..3278085 Escherichia coli ED1a 7140210 YP_002399213.1 CDS yqeB NC_011745.1 3278126 3279751 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3278126..3279751) Escherichia coli ED1a 7140312 YP_002399214.1 CDS yqeC NC_011745.1 3279799 3280569 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3279799..3280569) Escherichia coli ED1a 7140313 YP_002399215.1 CDS ygfJ NC_011745.1 3280673 3281251 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3280673..3281251 Escherichia coli ED1a 7140314 YP_002399216.1 CDS ygfK NC_011745.1 3281573 3284671 D with YgfM and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfK mutants are unable to reduce selenate; involved in purine salvage process; seems to act as an oxidoreductase, but sequence similarity suggests it is a dihydrothymine dehydrogenase; putative selenate reductase subunit YgfK 3281573..3284671 Escherichia coli ED1a 7139605 YP_002399217.1 CDS ssnA NC_011745.1 3284674 3286002 D in Escherichia coli expression is induced in response to phase-specific signals and controlled by RpoS; putative chlorohydrolase/aminohydrolase 3284674..3286002 Escherichia coli ED1a 7139606 YP_002399218.1 CDS ygfM NC_011745.1 3286053 3286832 D with YgfK and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfM contains a FAD domain; putative selenate reductase subunit YgfM 3286053..3286832 Escherichia coli ED1a 7143850 YP_002399219.1 CDS xdhD NC_011745.1 3286829 3289699 D with YgfK and YgfM forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; molybdopterin-containing enzyme; oxidase activity toward hypoxanthine and xanthine can be detected if these substrates are present at high concentration; putative selenate reductase subunit YgfN 3286829..3289699 Escherichia coli ED1a 7139607 YP_002399220.1 CDS ygfO NC_011745.1 3289864 3291264 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20372655, 98213740; Product type pt : putative transporter; putative transporter 3289864..3291264 Escherichia coli ED1a 7139205 YP_002399221.1 CDS guaD NC_011745.1 3291279 3292598 D Catalyzes the deamination of guanine; guanine deaminase 3291279..3292598 Escherichia coli ED1a 7139608 YP_002399222.1 CDS ygfQ NC_011745.1 3292634 3294001 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 3292634..3294001 Escherichia coli ED1a 7139846 YP_002399223.1 CDS ygfS NC_011745.1 3294037 3294525 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative oxidoreductase, 4Fe-4S ferredoxin-type subunit complement(3294037..3294525) Escherichia coli ED1a 7139609 YP_002399224.1 CDS ygfT NC_011745.1 3294525 3296444 R unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic); putative oxidoreductase Fe-S binding subunit complement(3294525..3296444) Escherichia coli ED1a 7139610 YP_002399225.1 CDS ygfU NC_011745.1 3296880 3298328 D Evidence 2b : Function of strongly homologous gene; PubMedId : 9098051; Product type t : transporter; transporter 3296880..3298328 Escherichia coli ED1a 7139611 YP_002399226.1 CDS idi NC_011745.1 3298578 3299126 D catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate; isopentenyl-diphosphate delta-isomerase 3298578..3299126 Escherichia coli ED1a 7139612 YP_002399227.1 CDS lysS NC_011745.1 3299169 3300686 R class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase complement(3299169..3300686) Escherichia coli ED1a 7140224 YP_002399228.1 CDS prfB NC_011745.1 3300696 3301794 R recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 complement(join(3300696..3301718,3301720..3301794)) Escherichia coli ED1a 7141935 YP_002399229.1 CDS recJ NC_011745.1 3301885 3303618 R 5'-3' single-stranded-DNA-specific exonuclease; ssDNA exonuclease RecJ complement(3301885..3303618) Escherichia coli ED1a 7139116 YP_002399230.1 CDS dsbC NC_011745.1 3303624 3304334 R DsbC; periplasmic protein with protein disulfide isomerase activity; this protein also shows disulfide oxidoreductase activity; thiol:disulfide interchange protein DsbC complement(3303624..3304334) Escherichia coli ED1a 7141580 YP_002399231.1 CDS xerD NC_011745.1 3304359 3305255 R site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD complement(3304359..3305255) Escherichia coli ED1a 7140523 YP_002399232.1 CDS fldB NC_011745.1 3305367 3305888 D An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic; flavodoxin FldB 3305367..3305888 Escherichia coli ED1a 7139207 YP_002399233.1 CDS ygfX NC_011745.1 3305928 3306335 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3305928..3306335) Escherichia coli ED1a 7144197 YP_002399234.1 CDS ygfY NC_011745.1 3306316 3306582 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3306316..3306582) Escherichia coli ED1a 7139613 YP_002399235.1 CDS ygfZ NC_011745.1 3306825 3307805 D physiological role is not clear; not essential for growth but mutants grow poorly; mutations suppress hda null mutations; may be involved in regulation of ATP-DnaA levels; may also be involved in regulation of tRNA modifications; can bind folic acid and tetrahydrofolate; forms a three domain ring-like structure with a central channel; structurally similar to DMGO protein from A. globiformis; shows sequence similarity to yeast CAF17 transcriptional regulator; putative global regulator 3306825..3307805 Escherichia coli ED1a 7139614 YP_002399236.1 CDS yqfA NC_011745.1 3307882 3308541 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative hemolysin, inner membrane subunit complement(3307882..3308541) Escherichia coli ED1a 7139615 YP_002399237.1 CDS yqfB NC_011745.1 3308705 3309016 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3308705..3309016) Escherichia coli ED1a 7140317 YP_002399238.1 CDS bglA NC_011745.1 3309055 3310494 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87222180, 88297127, 92334140; Product type e : enzyme; 6-phospho-beta-glucosidase A 3309055..3310494 Escherichia coli ED1a 7140318 YP_002399239.1 CDS gcvP NC_011745.1 3310660 3313533 R acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase complement(3310660..3313533) Escherichia coli ED1a 7140443 YP_002399240.1 CDS gcvH NC_011745.1 3313651 3314040 R part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor; glycine cleavage system protein H complement(3313651..3314040) Escherichia coli ED1a 7143170 YP_002399241.1 CDS gcvT NC_011745.1 3314064 3315158 R catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T complement(3314064..3315158) Escherichia coli ED1a 7143169 YP_002399242.1 CDS visC NC_011745.1 3315606 3316808 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1339425; Product type pe : putative enzyme; hypothetical protein complement(3315606..3316808) Escherichia coli ED1a 7143172 YP_002399243.1 CDS ubiH NC_011745.1 3316831 3318009 R Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone; 2-octaprenyl-6-methoxyphenyl hydroxylase complement(3316831..3318009) Escherichia coli ED1a 7139167 YP_002399244.1 CDS pepP NC_011745.1 3318006 3319331 R exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue; substrate can be as short as a dipeptide; proline aminopeptidase P II complement(3318006..3319331) Escherichia coli ED1a 7140863 YP_002399245.1 CDS ygfB NC_011745.1 3319357 3319935 R the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown; hypothetical protein complement(3319357..3319935) Escherichia coli ED1a 7144063 YP_002399246.1 CDS zapA NC_011745.1 3320103 3320432 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 412171; Product type cp : cell process; Z-ring-associated protein 3320103..3320432 Escherichia coli ED1a 7139603 YP_002399247.1 CDS ygfA NC_011745.1 3320732 3321280 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14727089, 2579060; Product type pe : putative enzyme; putative ligase 3320732..3321280 Escherichia coli ED1a 7143854 YP_002399248.1 CDS serA NC_011745.1 3321669 3322901 R catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase complement(3321669..3322901) Escherichia coli ED1a 7141349 YP_002399249.1 CDS rpiA NC_011745.1 3323157 3323816 R Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A complement(3323157..3323816) Escherichia coli ED1a 7141397 YP_002399250.1 CDS yqfE NC_011745.1 3323872 3324102 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3323872..3324102) Escherichia coli ED1a 7141449 YP_002399251.1 CDS argP NC_011745.1 3324243 3325136 D specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport; chromosome replication initiation inhibitor protein 3324243..3325136 Escherichia coli ED1a 7140319 YP_002399252.1 CDS ygfI NC_011745.1 3326430 3327326 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(3326430..3327326) Escherichia coli ED1a 7140971 YP_002399253.1 CDS yggE NC_011745.1 3327484 3328224 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3327484..3328224) Escherichia coli ED1a 7139604 YP_002399254.1 CDS argO NC_011745.1 3328317 3328952 R Involved in the export of arginine; arginine exporter protein complement(3328317..3328952) Escherichia coli ED1a 7139618 YP_002399255.1 CDS mscS NC_011745.1 3329091 3329951 R participates in the regulation of osmotic pressure changes within the cel; mechanosensitive channel MscS complement(3329091..3329951) Escherichia coli ED1a 7142617 YP_002399256.1 CDS fbaA NC_011745.1 3330142 3331221 R catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase complement(3330142..3331221) Escherichia coli ED1a 7139033 YP_002399257.1 CDS pgk NC_011745.1 3331436 3332599 R Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase complement(3331436..3332599) Escherichia coli ED1a 7144131 YP_002399258.1 CDS epd NC_011745.1 3332649 3333668 R NAD-dependent; catalyzes the formation of 4-phosphoerythronate from erythrose 4-phosphate in the biosynthesis of pyridoxine 5'-phosphate; erythrose 4-phosphate dehydrogenase complement(3332649..3333668) Escherichia coli ED1a 7144075 YP_002399259.1 CDS ECED1_3384 NC_011745.1 3334040 3334471 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3334040..3334471 Escherichia coli ED1a 7139803 YP_002399260.1 CDS ECED1_3385 NC_011745.1 3334494 3335072 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC-type transport system 3334494..3335072 Escherichia coli ED1a 7141266 YP_002399261.1 CDS ECED1_3386 NC_011745.1 3335073 3335780 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC-type transport system 3335073..3335780 Escherichia coli ED1a 7141267 YP_002399262.1 CDS ECED1_3387 NC_011745.1 3335762 3336445 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ATP-binding protein of ABC transport system 3335762..3336445 Escherichia coli ED1a 7141268 YP_002399263.1 CDS ECED1_3388 NC_011745.1 3336406 3337116 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ATP-binding protein of ABC transport system 3336406..3337116 Escherichia coli ED1a 7141269 YP_002399264.1 CDS frcK NC_011745.1 3337088 3337801 R Evidence 4 : Homologs of previously reported genes of unknown function; putative fructose transport system kinase complement(3337088..3337801) Escherichia coli ED1a 7141270 YP_002399265.1 CDS yggD NC_011745.1 3337798 3338307 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(3337798..3338307) Escherichia coli ED1a 7139616 YP_002399266.1 CDS yggP NC_011745.1 3338641 3339918 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative dehydrogenase complement(3338641..3339918) Escherichia coli ED1a 7139620 YP_002399267.1 CDS cmtA NC_011745.1 3339933 3341321 R Evidence 2b : Function of strongly homologous gene; PubMedId : 8353127; Product type t : transporter; fused mannitol-specific PTS enzymes: IIB component ; IIC component complement(3339933..3341321) Escherichia coli ED1a 7139627 YP_002399268.1 CDS cmtB NC_011745.1 3341349 3341792 R TolM; with CmtA (IIBC), CmtB possibly forms the mannitol-like permease component of the cryptic mannitol phosphotransferase system, which phosphorylates and transports various carbohydrates and polyhydric alcohols in Escherichia coli; cytoplasmic protein; putative mannitol phosphotransferase subunit EIIA complement(3341349..3341792) Escherichia coli ED1a 7139382 YP_002399269.1 CDS ECED1_3396 NC_011745.1 3342109 3343077 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane protease 3342109..3343077 Escherichia coli ED1a 7139383 YP_002399270.1 CDS tktA NC_011745.1 3343296 3345287 R catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase complement(3343296..3345287) Escherichia coli ED1a 7141271 YP_002399271.1 CDS yggG NC_011745.1 3345565 3346323 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1310091; Product type pe : putative enzyme; putative peptidase 3345565..3346323 Escherichia coli ED1a 7141559 YP_002399272.1 CDS speB NC_011745.1 3346527 3347447 R catalyzes the formation of putrescine from agmatine; agmatinase complement(3346527..3347447) Escherichia coli ED1a 7139621 YP_002399273.1 CDS ECED1_3400 NC_011745.1 3347583 3348314 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3347583..3348314) Escherichia coli ED1a 7143824 YP_002399274.1 CDS speA NC_011745.1 3348460 3350436 R catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis; arginine decarboxylase complement(3348460..3350436) Escherichia coli ED1a 7141272 YP_002399275.1 CDS yqgB NC_011745.1 3350445 3350591 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3350445..3350591) Escherichia coli ED1a 7143823 YP_002399276.1 CDS yqgC NC_011745.1 3350712 3350927 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3350712..3350927 Escherichia coli ED1a 7140321 YP_002399277.1 CDS yqgD NC_011745.1 3350924 3351175 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(3350924..3351175) Escherichia coli ED1a 7140322 YP_002399278.1 CDS metK NC_011745.1 3351231 3352385 D catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 3351231..3352385 Escherichia coli ED1a 7143354 YP_002399279.1 CDS galP NC_011745.1 3352821 3354215 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9182541; Product type t : transporter; D-galactose transporter 3352821..3354215 Escherichia coli ED1a 7142257 YP_002399280.1 CDS sprT NC_011745.1 3354292 3354789 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7984428, 8113204; hypothetical protein 3354292..3354789 Escherichia coli ED1a 7143152 YP_002399281.1 CDS endA NC_011745.1 3354884 3355591 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 72060411, 92335461, 4955462, 7867949, 8113204; Product type e : enzyme; DNA-specific endonuclease I 3354884..3355591 Escherichia coli ED1a 7143834 YP_002399282.1 CDS yggJ NC_011745.1 3355671 3356402 D in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 3355671..3356402 Escherichia coli ED1a 7139792 YP_002399283.1 CDS gshB NC_011745.1 3356415 3357365 D catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione; glutathione synthetase 3356415..3357365 Escherichia coli ED1a 7139623 YP_002399284.1 CDS yqgE NC_011745.1 3357474 3358037 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3357474..3358037 Escherichia coli ED1a 7143028 YP_002399285.1 CDS yqgF NC_011745.1 3358037 3358453 D similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 3358037..3358453 Escherichia coli ED1a 7143202 YP_002399286.1 CDS yggR NC_011745.1 3358627 3359607 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1676385; Product type t : transporter; transporter complement(3358627..3359607) Escherichia coli ED1a 7143203 YP_002399287.1 CDS yggS NC_011745.1 3359625 3360329 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 3359625..3360329 Escherichia coli ED1a 7139628 YP_002399288.1 CDS yggT NC_011745.1 3360347 3360913 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3360347..3360913 Escherichia coli ED1a 7139629 YP_002399289.1 CDS yggU NC_011745.1 3360910 3361200 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12975589; hypothetical protein 3360910..3361200 Escherichia coli ED1a 7139630 YP_002399290.1 CDS yggV NC_011745.1 3361208 3361801 D HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; putative deoxyribonucleotide triphosphate pyrophosphatase 3361208..3361801 Escherichia coli ED1a 7139631 YP_002399291.1 CDS yggW NC_011745.1 3361794 3362930 D catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 3361794..3362930 Escherichia coli ED1a 7139632 YP_002399292.1 CDS yggM NC_011745.1 3362999 3364006 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3362999..3364006) Escherichia coli ED1a 7139633 YP_002399293.1 CDS ansB NC_011745.1 3364123 3365169 R catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis; L-asparaginase II complement(3364123..3365169) Escherichia coli ED1a 7139625 YP_002399294.1 CDS yggN NC_011745.1 3365345 3366064 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11274153; hypothetical protein complement(3365345..3366064) Escherichia coli ED1a 7142584 YP_002399295.1 CDS yggL NC_011745.1 3366248 3366574 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3366248..3366574) Escherichia coli ED1a 7139626 YP_002399296.1 CDS trmB NC_011745.1 3366574 3367293 R tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase complement(3366574..3367293) Escherichia coli ED1a 7139624 YP_002399297.1 CDS mutY NC_011745.1 3367454 3368506 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14730969, 20187555, 20316830, 20580749, 21438845, 90046892, 92409600, 9801309, 2001994, 2197596, 9846876; Product type e : enzyme; adenine DNA glycosylase 3367454..3368506 Escherichia coli ED1a 7139622 YP_002399298.1 CDS yggX NC_011745.1 3368534 3368809 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594836, 10493123, 9298646, 9868784; Product type f : factor; hypothetical protein 3368534..3368809 Escherichia coli ED1a 7139059 YP_002399299.1 CDS mltC NC_011745.1 3368874 3369953 D Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase C 3368874..3369953 Escherichia coli ED1a 7139634 YP_002399300.1 CDS nupG NC_011745.1 3370155 3371411 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88029453, 90323001, 3311747; Product type t : transporter; nucleoside transporter 3370155..3371411 Escherichia coli ED1a 7138992 YP_002399301.1 CDS speC NC_011745.1 3371460 3373595 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87222180, 87260820; Product type e : enzyme; ornithine decarboxylase complement(3371460..3373595) Escherichia coli ED1a 7139958 YP_002399302.1 CDS yqgA NC_011745.1 3373994 3374701 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3373994..3374701 Escherichia coli ED1a 7143825 YP_002399303.1 CDS ECED1_3430 NC_011745.1 3375080 3376342 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; integrase 3375080..3376342 Escherichia coli ED1a 7140577 YP_002399304.1 CDS insB NC_011745.1 3376706 3377023 R Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS1 complement(3376706..3377023) Escherichia coli ED1a 7141148 YP_002399305.1 CDS insA NC_011745.1 3376942 3377217 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF 1, IS1 complement(3376942..3377217) Escherichia coli ED1a 7141149 YP_002399306.1 CDS ECED1_3434 NC_011745.1 3377360 3378859 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative Amino acid transporter complement(3377360..3378859) Escherichia coli ED1a 7141126 YP_002399307.1 CDS ECED1_3435 NC_011745.1 3378934 3381303 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Orn/Lys/Arg decarboxylase complement(3378934..3381303) Escherichia coli ED1a 7141274 YP_002399308.1 CDS ECED1_3436 NC_011745.1 3381408 3382877 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; hypothetical protein complement(3381408..3382877) Escherichia coli ED1a 7141275 YP_002399309.1 CDS ECED1_3437 NC_011745.1 3383130 3383402 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase InsA (ORF1) IS1 3383130..3383402 Escherichia coli ED1a 7141276 YP_002399310.1 CDS ECED1_3438 NC_011745.1 3383429 3383788 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase InsB (ORF2) IS1 3383429..3383788 Escherichia coli ED1a 7141277 YP_002399311.1 CDS ECED1_3439 NC_011745.1 3383824 3384048 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3383824..3384048 Escherichia coli ED1a 7141278 YP_002399312.1 CDS ECED1_3440 NC_011745.1 3384411 3384806 D Evidence 4 : Homologs of previously reported genes of unknown function; putative Zn-dependent alcohol dehydrogenases 3384411..3384806 Escherichia coli ED1a 7141279 YP_002399313.1 CDS ECED1_3442 NC_011745.1 3386302 3387837 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3386302..3387837) Escherichia coli ED1a 7141281 YP_002399314.1 CDS ECED1_3443 NC_011745.1 3388076 3388474 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3388076..3388474) Escherichia coli ED1a 7141282 YP_002399315.1 CDS ECED1_3444 NC_011745.1 3388546 3388983 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3388546..3388983) Escherichia coli ED1a 7141283 YP_002399316.1 CDS ECED1_3445 NC_011745.1 3389576 3389767 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3389576..3389767 Escherichia coli ED1a 7141284 YP_002399317.1 CDS ECED1_3446 NC_011745.1 3389820 3390128 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3389820..3390128) Escherichia coli ED1a 7141285 YP_002399318.1 CDS ECED1_3447 NC_011745.1 3390149 3390550 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3390149..3390550) Escherichia coli ED1a 7141286 YP_002399319.1 CDS ECED1_3448 NC_011745.1 3390999 3392117 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative propanol dehydrogenase 3390999..3392117 Escherichia coli ED1a 7141287 YP_002399320.1 CDS ECED1_3449 NC_011745.1 3392257 3392943 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10498708; hypothetical protein 3392257..3392943 Escherichia coli ED1a 7141288 YP_002399321.1 CDS ECED1_3450 NC_011745.1 3392998 3393756 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative ethanolamine utilization protein (eutJ-like) 3392998..3393756 Escherichia coli ED1a 7141289 YP_002399322.1 CDS ECED1_3451 NC_011745.1 3393740 3394465 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3393740..3394465 Escherichia coli ED1a 7141290 YP_002399323.1 CDS ECED1_3452 NC_011745.1 3394477 3394746 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative Ethanolamine utilization protein (eutN-like) 3394477..3394746 Escherichia coli ED1a 7141291 YP_002399324.1 CDS ECED1_3453 NC_011745.1 3394774 3395271 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3394774..3395271 Escherichia coli ED1a 7141292 YP_002399325.1 CDS ECED1_3455 NC_011745.1 3395189 3396496 D catalyzes the formation of propanoyl phosphate from propanoate and ATP; TdcD also has acetate kinase activities and functions in anaerobic threonine catabolism; propionate/acetate kinase 3395189..3396496 Escherichia coli ED1a 7141293 YP_002399326.1 CDS ECED1_3456 NC_011745.1 3396730 3397062 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10498708; Product type ps : putative structure; putative propanediol utilization protein, polyhedral bodies (pduA-like) 3396730..3397062 Escherichia coli ED1a 7141294 YP_002399327.1 CDS ECED1_3457 NC_011745.1 3397084 3397869 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative propanediol utilization protein, polyhedral bodies (pduB-like) 3397084..3397869 Escherichia coli ED1a 7141295 YP_002399328.1 CDS ECED1_3458 NC_011745.1 3397930 3399456 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7868611, 10464203; Product type pe : putative enzyme; putative acetaldehyde/propionaldehyde dehydrogenase 3397930..3399456 Escherichia coli ED1a 7141296 YP_002399329.1 CDS ECED1_3459 NC_011745.1 3399480 3399779 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3399480..3399779 Escherichia coli ED1a 7141297 YP_002399330.1 CDS ECED1_3460 NC_011745.1 3399655 3400365 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8626329; hypothetical protein 3399655..3400365 Escherichia coli ED1a 7141298 YP_002399331.1 CDS ECED1_3461 NC_011745.1 3400414 3402966 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Formate C-acetyltransferase 3400414..3402966 Escherichia coli ED1a 7141299 YP_002399332.1 CDS ECED1_3462 NC_011745.1 3403075 3403992 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 3053170; Product type pe : putative enzyme; putative pyruvate formate-lyase 3-activating enzyme 3403075..3403992 Escherichia coli ED1a 7141300 YP_002399333.1 CDS ECED1_3463 NC_011745.1 3404129 3405034 D Evidence 4 : Homologs of previously reported genes of unknown function; putative permease 3404129..3405034 Escherichia coli ED1a 7141301 YP_002399334.1 CDS ECED1_3464 NC_011745.1 3405520 3406059 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative maturase-related protein 3405520..3406059 Escherichia coli ED1a 7141302 YP_002399335.1 CDS ECED1_3465 NC_011745.1 3406087 3406608 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative maturase-related protein 3406087..3406608 Escherichia coli ED1a 7141303 YP_002399336.1 CDS ECED1_3467 NC_011745.1 3406707 3406820 D Evidence 6 : Doubtful CDS; hypothetical protein 3406707..3406820 Escherichia coli ED1a 7141304 YP_002399337.1 CDS ECED1_3468 NC_011745.1 3407158 3408420 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3407158..3408420 Escherichia coli ED1a 7140763 YP_002399338.1 CDS ECED1_3469 NC_011745.1 3408437 3409492 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3408437..3409492 Escherichia coli ED1a 7141306 YP_002399339.1 CDS metK NC_011745.1 3409621 3410772 D catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 3409621..3410772 Escherichia coli ED1a 7141307 YP_002399340.1 CDS ECED1_3472 NC_011745.1 3410721 3411362 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3410721..3411362 Escherichia coli ED1a 7142258 YP_002399341.1 CDS ECED1_3474 NC_011745.1 3411855 3412064 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3411855..3412064) Escherichia coli ED1a 7141309 YP_002399342.1 CDS ECED1_3475 NC_011745.1 3412335 3412706 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3412335..3412706) Escherichia coli ED1a 7141310 YP_002399343.1 CDS ECED1_3476 NC_011745.1 3412806 3413870 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3412806..3413870) Escherichia coli ED1a 7141311 YP_002399344.1 CDS ECED1_3478 NC_011745.1 3414392 3414583 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3414392..3414583 Escherichia coli ED1a 7141160 YP_002399345.1 CDS ECED1_3479 NC_011745.1 3414619 3414852 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3414619..3414852) Escherichia coli ED1a 7141313 YP_002399346.1 CDS ECED1_3480 NC_011745.1 3414921 3415685 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3414921..3415685) Escherichia coli ED1a 7141314 YP_002399347.1 CDS ECED1_3481 NC_011745.1 3415843 3416574 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3415843..3416574) Escherichia coli ED1a 7141315 YP_002399348.1 CDS ECED1_3482 NC_011745.1 3418027 3419250 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3418027..3419250) Escherichia coli ED1a 7141316 YP_002399349.1 CDS ECED1_3483 NC_011745.1 3419351 3420235 D Evidence 4 : Homologs of previously reported genes of unknown function; putative GTPase 3419351..3420235 Escherichia coli ED1a 7141317 YP_002399350.1 CDS ECED1_3485 NC_011745.1 3421161 3421943 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3421161..3421943 Escherichia coli ED1a 7141318 YP_002399351.1 CDS ECED1_3486 NC_011745.1 3421949 3422182 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3421949..3422182 Escherichia coli ED1a 7141319 YP_002399352.1 CDS ECED1_3487 NC_011745.1 3422272 3423090 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3422272..3423090 Escherichia coli ED1a 7141320 YP_002399353.1 CDS ECED1_3488 NC_011745.1 3423182 3423667 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7519596; Product type pf : putative factor; putative antirestriction protein (klcA-like) 3423182..3423667 Escherichia coli ED1a 7141321 YP_002399354.1 CDS yeeS NC_011745.1 3423713 3424159 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11053371; Product type pf : putative factor; putative DNA repair protein; CP4-44 prophage 3423713..3424159 Escherichia coli ED1a 7141322 YP_002399355.1 CDS yeeT NC_011745.1 3424222 3424443 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 3424222..3424443 Escherichia coli ED1a 7139386 YP_002399356.1 CDS ECED1_3491 NC_011745.1 3424443 3424556 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3424443..3424556 Escherichia coli ED1a 7139391 YP_002399357.1 CDS yeeU NC_011745.1 3424606 3424974 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594833; Product type h : extrachromosomal origin; CP4-44 prophage YeeV-YeeU toxin-antitoxin system toxin 3424606..3424974 Escherichia coli ED1a 7141323 YP_002399358.1 CDS yeeV NC_011745.1 3425064 3425438 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594833; Product type h : extrachromosomal origin; toxin of the YeeV-YeeU toxin-antitoxin system; CP4-44 prophage 3425064..3425438 Escherichia coli ED1a 7139396 YP_002399359.1 CDS yeeW NC_011745.1 3425435 3425923 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3425435..3425923 Escherichia coli ED1a 7139401 YP_002399360.1 CDS ECED1_3495 NC_011745.1 3425890 3426132 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3425890..3426132 Escherichia coli ED1a 7139405 YP_002399361.1 CDS ECED1_3497 NC_011745.1 3427130 3427705 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3427130..3427705) Escherichia coli ED1a 7141325 YP_002399362.1 CDS ECED1_3498 NC_011745.1 3427895 3428038 R Evidence 6 : Doubtful CDS; hypothetical protein complement(3427895..3428038) Escherichia coli ED1a 7141326 YP_002399363.1 CDS ECED1_3499 NC_011745.1 3428164 3429861 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3428164..3429861) Escherichia coli ED1a 7141327 YP_002399364.1 CDS ECED1_3500 NC_011745.1 3429755 3431263 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3429755..3431263) Escherichia coli ED1a 7141328 YP_002399365.1 CDS ECED1_3501 NC_011745.1 3431803 3432033 D Rac prophage; hypothetical protein 3431803..3432033 Escherichia coli ED1a 7141329 YP_002399366.1 CDS ECED1_3503 NC_011745.1 3433205 3433639 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative PilM protein 3433205..3433639 Escherichia coli ED1a 7141331 YP_002399367.1 CDS ECED1_3504 NC_011745.1 3433848 3435449 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative type IV pilus outer membrane secretin lipoprotein 3433848..3435449 Escherichia coli ED1a 7141332 YP_002399368.1 CDS ECED1_3505 NC_011745.1 3435461 3436768 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative Pilin accessory protein pilO 3435461..3436768 Escherichia coli ED1a 7141333 YP_002399369.1 CDS pilP NC_011745.1 3436758 3437219 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12011003; Product type s : structure; Pilus type IV assembly protein 3436758..3437219 Escherichia coli ED1a 7141334 YP_002399370.1 CDS pilQ NC_011745.1 3437229 3438749 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; Type IV pilus (ATPase) 3437229..3438749 Escherichia coli ED1a 7144114 YP_002399371.1 CDS ECED1_3508 NC_011745.1 3438685 3439851 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; membrane protein 3438685..3439851 Escherichia coli ED1a 7144115 YP_002399372.1 CDS pilS NC_011745.1 3439903 3440436 D Evidence 2b : Function of strongly homologous gene; PubMedId : 12011003; Product type pm : putative membrane component; major pillin subunit 3439903..3440436 Escherichia coli ED1a 7141335 YP_002399373.1 CDS ECED1_3510 NC_011745.1 3440495 3440971 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; Peptidoglycan-binding-like protein 3440495..3440971 Escherichia coli ED1a 7144116 YP_002399374.1 CDS pilU NC_011745.1 3440978 3441634 D Evidence 2b : Function of strongly homologous gene; PubMedId : 12011003; Product type pm : putative membrane component; Prepilin peptidase 3440978..3441634 Escherichia coli ED1a 7141336 YP_002399375.1 CDS pilV NC_011745.1 3441631 3442974 D Evidence 2b : Function of strongly homologous gene; PubMedId : 3029698; Product type m : membrane component; minor pilin subunit 3441631..3442974 Escherichia coli ED1a 7144117 YP_002399376.1 CDS pilV NC_011745.1 3442979 3443368 R Evidence 2b : Function of strongly homologous gene; PubMedId : 9603870; Product type m : membrane component; fragment of prepilin, shufflon protein (C-ter part) complement(3442979..3443368) Escherichia coli ED1a 7138978 YP_002399377.1 CDS pilV NC_011745.1 3443371 3443604 D Evidence 2b : Function of strongly homologous gene; PubMedId : 9603870; Product type m : membrane component; fragment of prepilin, shufflon protein (C-ter part) 3443371..3443604 Escherichia coli ED1a 7139060 YP_002399378.1 CDS pilV NC_011745.1 3443601 3443834 R Evidence 2b : Function of strongly homologous gene; PubMedId : 9603870; Product type m : membrane component; fragment of pilV protein, Shufflon protein (C-ter part) complement(3443601..3443834) Escherichia coli ED1a 7139061 YP_002399379.1 CDS rci NC_011745.1 3443889 3445013 D Evidence 2b : Function of strongly homologous gene; PubMedId : 3065610; Product type e : enzyme; Shufflon-specific DNA recombinase 3443889..3445013 Escherichia coli ED1a 7139062 YP_002399380.1 CDS ECED1_3518 NC_011745.1 3445332 3445484 R Evidence 6 : Doubtful CDS; hypothetical protein complement(3445332..3445484) Escherichia coli ED1a 7141262 YP_002399381.1 CDS ECED1_3519 NC_011745.1 3445574 3446395 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 3445574..3446395 Escherichia coli ED1a 7141337 YP_002399382.1 CDS traF NC_011745.1 3446437 3447687 D Evidence 4 : Homologs of previously reported genes of unknown function; putative plasmid transfer protein 3446437..3447687 Escherichia coli ED1a 7141338 YP_002399383.1 CDS ECED1_3523 NC_011745.1 3452520 3452912 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(3452520..3452912) Escherichia coli ED1a 7141370 YP_002399384.1 CDS ECED1_3524 NC_011745.1 3453276 3453668 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3453276..3453668 Escherichia coli ED1a 7141339 YP_002399385.1 CDS ECED1_3525 NC_011745.1 3453728 3454009 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3453728..3454009 Escherichia coli ED1a 7141340 YP_002399386.1 CDS ECED1_3526 NC_011745.1 3453999 3455792 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(3453999..3455792) Escherichia coli ED1a 7141341 YP_002399387.1 CDS ECED1_3527 NC_011745.1 3455947 3456684 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(3455947..3456684) Escherichia coli ED1a 7141342 YP_002399388.1 CDS ECED1_3528 NC_011745.1 3456810 3457607 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3456810..3457607) Escherichia coli ED1a 7141343 YP_002399389.1 CDS ECED1_3529 NC_011745.1 3457619 3458599 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3457619..3458599) Escherichia coli ED1a 7141344 YP_002399390.1 CDS ECED1_3530 NC_011745.1 3458674 3459135 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(3458674..3459135) Escherichia coli ED1a 7141345 YP_002399391.1 CDS ECED1_3531 NC_011745.1 3459185 3459808 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(3459185..3459808) Escherichia coli ED1a 7141346 YP_002399392.1 CDS ECED1_3532 NC_011745.1 3459591 3460025 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(3459591..3460025) Escherichia coli ED1a 7140487 YP_002399393.1 CDS ECED1_3533 NC_011745.1 3460061 3461143 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3460061..3461143) Escherichia coli ED1a 7141707 YP_002399394.1 CDS ECED1_3534 NC_011745.1 3461137 3461556 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(3461137..3461556) Escherichia coli ED1a 7141708 YP_002399395.1 CDS ECED1_3535 NC_011745.1 3461673 3462152 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(3461673..3462152) Escherichia coli ED1a 7141709 YP_002399396.1 CDS ECED1_3536 NC_011745.1 3462253 3462639 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(3462253..3462639) Escherichia coli ED1a 7141710 YP_002399397.1 CDS insA NC_011745.1 3463210 3463485 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF 1, IS1 3463210..3463485 Escherichia coli ED1a 7141711 YP_002399398.1 CDS insB NC_011745.1 3463404 3463907 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF2, IS1 3463404..3463907 Escherichia coli ED1a 7141127 YP_002399399.1 CDS ECED1_3539 NC_011745.1 3464521 3465216 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3464521..3465216 Escherichia coli ED1a 7141150 YP_002399400.1 CDS ECED1_3540 NC_011745.1 3465251 3465523 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3465251..3465523) Escherichia coli ED1a 7141712 YP_002399401.1 CDS ECED1_3541 NC_011745.1 3465523 3466230 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3465523..3466230) Escherichia coli ED1a 7141713 YP_002399402.1 CDS ECED1_3542 NC_011745.1 3467642 3468058 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3467642..3468058 Escherichia coli ED1a 7141714 YP_002399403.1 CDS rpmE2 NC_011745.1 3469375 3469638 R RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 type B complement(3469375..3469638) Escherichia coli ED1a 7141715 YP_002399404.1 CDS ECED1_3544 NC_011745.1 3469747 3469893 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(3469747..3469893) Escherichia coli ED1a 7140955 YP_002399405.1 CDS ECED1_3545 NC_011745.1 3470064 3470795 D Evidence 1b : Function experimentally demonstrated in the studied species; Product type m : membrane component; conjugal transfer surface exclusion protein TraT 3470064..3470795 Escherichia coli ED1a 7141716 YP_002399406.1 CDS ECED1_3546 NC_011745.1 3470843 3471847 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8451198, 8276869; Product type pe : putative enzyme; putative Restriction enzyme subunit beta complement(3470843..3471847) Escherichia coli ED1a 7141717 YP_002399407.1 CDS ECED1_3547 NC_011745.1 3471816 3473705 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8451198, 8276869; Product type pe : putative enzyme; putative Restriction enzyme subunit alpha complement(3471816..3473705) Escherichia coli ED1a 7141718 YP_002399408.1 CDS ECED1_3549 NC_011745.1 3475015 3475890 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3475015..3475890) Escherichia coli ED1a 7143101 YP_002399409.1 CDS ECED1_3550 NC_011745.1 3476314 3476583 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3476314..3476583) Escherichia coli ED1a 7141720 YP_002399410.1 CDS ireA NC_011745.1 3476932 3478980 R iron-responsive element (ireA); ireA gene is located on pathogenicity island I (PAI I); outer membrane protein; putative iron-regulated outer membrane virulence protein complement(3476932..3478980) Escherichia coli ED1a 7141721 YP_002399411.1 CDS ECED1_3552 NC_011745.1 3479148 3479303 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(3479148..3479303) Escherichia coli ED1a 7142447 YP_002399412.1 CDS ECED1_3553 NC_011745.1 3479803 3480057 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3479803..3480057 Escherichia coli ED1a 7141722 YP_002399413.1 CDS ECED1_3554 NC_011745.1 3480094 3481614 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3480094..3481614) Escherichia coli ED1a 7141723 YP_002399414.1 CDS ECED1_3555 NC_011745.1 3481618 3482010 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(3481618..3482010) Escherichia coli ED1a 7141724 YP_002399415.1 CDS ECED1_3556 NC_011745.1 3481976 3483457 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3481976..3483457) Escherichia coli ED1a 7141725 YP_002399416.1 CDS ECED1_3557 NC_011745.1 3483409 3484383 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3483409..3484383) Escherichia coli ED1a 7141726 YP_002399417.1 CDS ECED1_3558 NC_011745.1 3484380 3484778 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3484380..3484778) Escherichia coli ED1a 7141727 YP_002399418.1 CDS ECED1_3559 NC_011745.1 3484642 3484920 R Evidence 6 : Doubtful CDS; hypothetical protein complement(3484642..3484920) Escherichia coli ED1a 7141728 YP_002399419.1 CDS ECED1_3560 NC_011745.1 3485005 3487095 R IrgA-homologue adhesin (Iha); TonB-dependent; acts as a specific receptor of enterobactin; fur-regulated; urovirulence factor; bifunctional enterobactin receptor/adhesin protein complement(3485005..3487095) Escherichia coli ED1a 7141729 YP_002399420.1 CDS ECED1_3561 NC_011745.1 3487487 3487873 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3487487..3487873) Escherichia coli ED1a 7141730 YP_002399421.1 CDS ECED1_3562 NC_011745.1 3487870 3490686 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative plasmid-related outer membrane ATPase complement(3487870..3490686) Escherichia coli ED1a 7141731 YP_002399422.1 CDS ECED1_3563 NC_011745.1 3490686 3491099 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; putative lipoprotein complement(3490686..3491099) Escherichia coli ED1a 7141732 YP_002399423.1 CDS ECED1_3564 NC_011745.1 3491117 3492595 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3491117..3492595) Escherichia coli ED1a 7141733 YP_002399424.1 CDS ECED1_3565 NC_011745.1 3492585 3493493 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3492585..3493493) Escherichia coli ED1a 7141734 YP_002399425.1 CDS ECED1_3566 NC_011745.1 3493490 3494137 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3493490..3494137) Escherichia coli ED1a 7141735 YP_002399426.1 CDS ECED1_3567 NC_011745.1 3494134 3494511 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3494134..3494511) Escherichia coli ED1a 7141736 YP_002399427.1 CDS ECED1_3568 NC_011745.1 3494518 3494895 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3494518..3494895) Escherichia coli ED1a 7141737 YP_002399428.1 CDS ECED1_3569 NC_011745.1 3494926 3495168 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3494926..3495168) Escherichia coli ED1a 7141738 YP_002399429.1 CDS ECED1_3570 NC_011745.1 3495168 3495530 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3495168..3495530) Escherichia coli ED1a 7141739 YP_002399430.1 CDS ECED1_3571 NC_011745.1 3495622 3496188 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3495622..3496188 Escherichia coli ED1a 7141740 YP_002399431.1 CDS ECED1_3572 NC_011745.1 3496223 3496387 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(3496223..3496387) Escherichia coli ED1a 7141741 YP_002399432.1 CDS ECED1_3573 NC_011745.1 3496643 3497410 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3496643..3497410) Escherichia coli ED1a 7141742 YP_002399433.1 CDS ECED1_3574 NC_011745.1 3497385 3499502 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative plasmid transfer protein complement(3497385..3499502) Escherichia coli ED1a 7141743 YP_002399434.1 CDS ECED1_3575 NC_011745.1 3499495 3500325 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(3499495..3500325) Escherichia coli ED1a 7141744 YP_002399435.1 CDS ECED1_3576 NC_011745.1 3500297 3500899 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme; putative restriction endonuclease complement(3500297..3500899) Escherichia coli ED1a 7141745 YP_002399436.1 CDS ECED1_3577 NC_011745.1 3500896 3501426 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3500896..3501426) Escherichia coli ED1a 7141746 YP_002399437.1 CDS ECED1_3578 NC_011745.1 3501423 3502085 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Lytic transglycosylase, catalytic complement(3501423..3502085) Escherichia coli ED1a 7141747 YP_002399438.1 CDS ECED1_3579 NC_011745.1 3502064 3502786 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3502064..3502786) Escherichia coli ED1a 7141748 YP_002399439.1 CDS ECED1_3580 NC_011745.1 3502791 3503558 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3502791..3503558) Escherichia coli ED1a 7141749 YP_002399440.1 CDS ECED1_3582 NC_011745.1 3504291 3504500 R Evidence 7 : Gene remnant; hypothetical protein complement(3504291..3504500) Escherichia coli ED1a 7144113 YP_002399441.1 CDS ECED1_3584 NC_011745.1 3505063 3506586 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative reverse transcriptase protein from putative prophage or plasmid complement(3505063..3506586) Escherichia coli ED1a 7140764 YP_002399442.1 CDS ECED1_3587 NC_011745.1 3508002 3508181 R Evidence 6 : Doubtful CDS; hypothetical protein complement(3508002..3508181) Escherichia coli ED1a 7141754 YP_002399443.1 CDS ECED1_3588 NC_011745.1 3508255 3509214 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3508255..3509214) Escherichia coli ED1a 7141755 YP_002399444.1 CDS ssb NC_011745.1 3509261 3509818 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type cp : cell process; Single-stranded DNA-binding protein complement(3509261..3509818) Escherichia coli ED1a 7141756 YP_002399445.1 CDS ECED1_3590 NC_011745.1 3509831 3510052 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3509831..3510052) Escherichia coli ED1a 7143846 YP_002399446.1 CDS ECED1_3591 NC_011745.1 3510146 3510559 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3510146..3510559) Escherichia coli ED1a 7141757 YP_002399447.1 CDS ECED1_3592 NC_011745.1 3510670 3510825 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3510670..3510825 Escherichia coli ED1a 7141758 YP_002399448.1 CDS kpsF NC_011745.1 3511600 3512619 D Evidence 2b : Function of strongly homologous gene; PubMedId : 8253690; Product type e : enzyme; Polysialic acid capsule expression protein 3511600..3512619 Escherichia coli ED1a 7141759 YP_002399449.1 CDS kpsE NC_011745.1 3512691 3513839 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8253690; Product type t : transporter; Capsule polysaccharide export inner-membrane protein 3512691..3513839 Escherichia coli ED1a 7142517 YP_002399450.1 CDS kpsD NC_011745.1 3513860 3515539 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8021185; Product type t : transporter; Polysialic acid transport protein 3513860..3515539 Escherichia coli ED1a 7142516 YP_002399451.1 CDS kpsU NC_011745.1 3515549 3516289 D CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 3515549..3516289 Escherichia coli ED1a 7142515 YP_002399452.1 CDS kpsC NC_011745.1 3516286 3518313 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8397187, 8326861; Product type t : transporter; Capsule polysaccharide export protein 3516286..3518313 Escherichia coli ED1a 7142521 YP_002399453.1 CDS kpsS NC_011745.1 3518348 3519586 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8397187, 8326861; Product type t : transporter; Capsule polysaccharide export protein 3518348..3519586 Escherichia coli ED1a 7142514 YP_002399454.1 CDS ECED1_3599 NC_011745.1 3519707 3520348 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3519707..3520348) Escherichia coli ED1a 7142519 YP_002399455.1 CDS ECED1_3600 NC_011745.1 3520436 3523888 R Evidence 4 : Homologs of previously reported genes of unknown function; putative hydrolase complement(3520436..3523888) Escherichia coli ED1a 7141760 YP_002399456.1 CDS kpsT NC_011745.1 3524137 3524805 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1856162, 8051103, 2082146; Product type t : transporter; Polysialic acid transport ATP-binding protein kpsT complement(3524137..3524805) Escherichia coli ED1a 7141761 YP_002399457.1 CDS kpsM NC_011745.1 3524802 3525638 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1856162, 7715449; Product type t : transporter; Polysialic acid transport protein complement(3524802..3525638) Escherichia coli ED1a 7142520 YP_002399458.1 CDS yghD NC_011745.1 3526751 3527287 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative general secretion pathway protein YghD complement(3526751..3527287) Escherichia coli ED1a 7142518 YP_002399459.1 CDS yghE NC_011745.1 3527289 3528467 R similar to general secretory pathway protein L; GspL-like protein complement(3527289..3528467) Escherichia coli ED1a 7139637 YP_002399460.1 CDS ECED1_3605 NC_011745.1 3528464 3529441 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; GspK-like type II secretion protein complement(3528464..3529441) Escherichia coli ED1a 7139638 YP_002399461.1 CDS ECED1_3606 NC_011745.1 3529438 3530043 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3529438..3530043) Escherichia coli ED1a 7141762 YP_002399462.1 CDS ECED1_3607 NC_011745.1 3530040 3530411 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative GspI-like type II secretion protein complement(3530040..3530411) Escherichia coli ED1a 7141763 YP_002399463.1 CDS ECED1_3608 NC_011745.1 3530408 3530971 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3530408..3530971) Escherichia coli ED1a 7141764 YP_002399464.1 CDS ECED1_3609 NC_011745.1 3530975 3531457 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative general secretion pathway protein G (epsG-like) complement(3530975..3531457) Escherichia coli ED1a 7141765 YP_002399465.1 CDS epsF NC_011745.1 3531447 3532670 R Evidence 2b : Function of strongly homologous gene; Product type t : transporter; General secretion pathway protein F complement(3531447..3532670) Escherichia coli ED1a 7141766 YP_002399466.1 CDS epsE NC_011745.1 3532670 3534163 R Evidence 2b : Function of strongly homologous gene; Product type t : transporter; general secretion pathway protein E complement(3532670..3534163) Escherichia coli ED1a 7139806 YP_002399467.1 CDS epsD NC_011745.1 3534163 3536223 R Evidence 2b : Function of strongly homologous gene; Product type t : transporter; general secretion pathway protein D complement(3534163..3536223) Escherichia coli ED1a 7139805 YP_002399468.1 CDS yghF NC_011745.1 3536253 3537212 R part of the general (type II) secretion pathway (GSP), a signal sequence-dependent process responsible for protein export; involved in trans-location of exoproteins from the cytoplasm to the periplasm; putative type II secretion protein GspC complement(3536253..3537212) Escherichia coli ED1a 7139804 YP_002399469.1 CDS yghG NC_011745.1 3537230 3537640 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3537230..3537640) Escherichia coli ED1a 7139639 YP_002399470.1 CDS pppA NC_011745.1 3537706 3538515 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98175453; Product type e : enzyme; bifunctional prepilin leader peptidase and methylase complement(3537706..3538515) Escherichia coli ED1a 7139640 YP_002399471.1 CDS yghJ NC_011745.1 3538679 3543259 R Evidence 2b : Function of strongly homologous gene; PubMedId : 1644747; Product type lp : lipoprotein; inner membrane lipoprotein complement(3538679..3543259) Escherichia coli ED1a 7139108 YP_002399472.1 CDS yghK NC_011745.1 3543725 3545407 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11785976, 21178909, 11283302; Product type t : transporter; glycolate transporter complement(3543725..3545407) Escherichia coli ED1a 7139641 YP_002399473.1 CDS glcB NC_011745.1 3545763 3547934 R catalyzes the formation of malate from glyoxylate and acetyl-CoA; malate synthase G complement(3545763..3547934) Escherichia coli ED1a 7140471 YP_002399474.1 CDS glcG NC_011745.1 3547956 3548360 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3547956..3548360) Escherichia coli ED1a 7143178 YP_002399475.1 CDS glcE NC_011745.1 3549597 3550649 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96178972, 8606183; Product type e : enzyme; glycolate oxidase FAD binding subunit complement(3549597..3550649) Escherichia coli ED1a 7143182 YP_002399476.1 CDS glcD NC_011745.1 3550649 3552148 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96178972, 8606183; Product type e : enzyme; glycolate oxidase subunit GlcD complement(3550649..3552148) Escherichia coli ED1a 7143181 YP_002399477.1 CDS glcC NC_011745.1 3552399 3553163 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96178972, 9880556, 8606183; Product type r : regulator; DNA-binding transcriptional regulator GlcC 3552399..3553163 Escherichia coli ED1a 7143180 YP_002399478.1 CDS yghO NC_011745.1 3553170 3554312 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(3553170..3554312) Escherichia coli ED1a 7143179 YP_002399479.1 CDS ECED1_3626 NC_011745.1 3556404 3557318 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative epimerase 3556404..3557318 Escherichia coli ED1a 7141767 YP_002399480.1 CDS ECED1_3627 NC_011745.1 3557350 3557598 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3557350..3557598 Escherichia coli ED1a 7141768 YP_002399481.1 CDS ECED1_3628 NC_011745.1 3557598 3558770 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative 8-amino-7-oxononanoate synthase 3557598..3558770 Escherichia coli ED1a 7141769 YP_002399482.1 CDS ECED1_3629 NC_011745.1 3558805 3559965 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3558805..3559965) Escherichia coli ED1a 7141770 YP_002399483.1 CDS ECED1_3630 NC_011745.1 3559881 3560951 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3559881..3560951) Escherichia coli ED1a 7141771 YP_002399484.1 CDS ECED1_3631 NC_011745.1 3560982 3561542 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator complement(3560982..3561542) Escherichia coli ED1a 7141772 YP_002399485.1 CDS ECED1_3632 NC_011745.1 3561542 3562378 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3561542..3562378) Escherichia coli ED1a 7141773 YP_002399486.1 CDS ECED1_3633 NC_011745.1 3562378 3563727 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein complement(3562378..3563727) Escherichia coli ED1a 7141774 YP_002399487.1 CDS yghR NC_011745.1 3563773 3564531 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3563773..3564531) Escherichia coli ED1a 7141775 YP_002399488.1 CDS yghS NC_011745.1 3564563 3565276 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3564563..3565276) Escherichia coli ED1a 7139644 YP_002399489.1 CDS yghT NC_011745.1 3565451 3566143 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3565451..3566143 Escherichia coli ED1a 7139645 YP_002399490.1 CDS pitB NC_011745.1 3566192 3567691 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21336523, 21382172, 7775463; Product type t : transporter; phosphate transporter complement(3566192..3567691) Escherichia coli ED1a 7139646 YP_002399491.1 CDS gss NC_011745.1 3567983 3569842 R catalyzes the formation of glutathionylspermidine from glutathione and spermidine; also catalyzes the reverse reaction; bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase complement(3567983..3569842) Escherichia coli ED1a 7139066 YP_002399492.1 CDS yghU NC_011745.1 3570047 3570913 D YghU; B2989; one of eight putative glutathione transferase proteins from E. coli; putative glutathione S-transferase YghU 3570047..3570913 Escherichia coli ED1a 7139841 YP_002399493.1 CDS hybG NC_011745.1 3571055 3571303 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92215587, 94292472, 8021226; Product type pf : putative factor; hydrogenase 2 accessory protein HypG complement(3571055..3571303) Escherichia coli ED1a 7139647 YP_002399494.1 CDS hybF NC_011745.1 3571316 3571657 R plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein HybF complement(3571316..3571657) Escherichia coli ED1a 7140192 YP_002399495.1 CDS hybE NC_011745.1 3571650 3572138 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94292472, 8021226; Product type f : factor; hydrogenase 2-specific chaperone complement(3571650..3572138) Escherichia coli ED1a 7140191 YP_002399496.1 CDS hybD NC_011745.1 3572131 3572625 R protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC); hydrogenase 2 maturation endopeptidase complement(3572131..3572625) Escherichia coli ED1a 7140190 YP_002399497.1 CDS hybC NC_011745.1 3572625 3574328 R involved in hydrogen uptake; hydrogenase 2 large subunit complement(3572625..3574328) Escherichia coli ED1a 7140189 YP_002399498.1 CDS hybB NC_011745.1 3574325 3575503 R HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits; putative hydrogenase 2 b cytochrome subunit complement(3574325..3575503) Escherichia coli ED1a 7140188 YP_002399499.1 CDS hybA NC_011745.1 3575493 3576479 R Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2; hydrogenase 2 protein HybA complement(3575493..3576479) Escherichia coli ED1a 7140187 YP_002399500.1 CDS hybO NC_011745.1 3576482 3577600 R involved in hydrogen uptake; hydrogenase 2 small subunit complement(3576482..3577600) Escherichia coli ED1a 7140186 YP_002399501.1 CDS ECED1_3648 NC_011745.1 3577607 3577792 R Evidence 6 : Doubtful CDS; hypothetical protein complement(3577607..3577792) Escherichia coli ED1a 7140193 YP_002399502.1 CDS yghW NC_011745.1 3577789 3578076 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3577789..3578076) Escherichia coli ED1a 7141776 YP_002399503.1 CDS ECED1_3650 NC_011745.1 3578195 3579121 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3578195..3579121) Escherichia coli ED1a 7139648 YP_002399504.1 CDS yghZ NC_011745.1 3579239 3580279 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12583903; Product type e : enzyme; aldo-keto reductase 3579239..3580279 Escherichia coli ED1a 7141777 YP_002399505.1 CDS yqhA NC_011745.1 3580319 3580813 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(3580319..3580813) Escherichia coli ED1a 7139649 YP_002399506.1 CDS yghA NC_011745.1 3581004 3581888 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; oxidoreductase 3581004..3581888 Escherichia coli ED1a 7143204 YP_002399507.1 CDS exbD NC_011745.1 3581927 3582352 R membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbD complement(3581927..3582352) Escherichia coli ED1a 7139635 YP_002399508.1 CDS exbB NC_011745.1 3582359 3583093 R membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbB complement(3582359..3583093) Escherichia coli ED1a 7139831 YP_002399509.1 CDS ECED1_3657 NC_011745.1 3583086 3583241 R Evidence 6 : Doubtful CDS; hypothetical protein complement(3583086..3583241) Escherichia coli ED1a 7139830 YP_002399510.1 CDS metC NC_011745.1 3583345 3584532 D catalyzes the formation of L-homocysteine from cystathionine; cystathionine beta-lyase 3583345..3584532 Escherichia coli ED1a 7141778 YP_002399511.1 CDS yghB NC_011745.1 3584672 3585331 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3584672..3585331 Escherichia coli ED1a 7142250 YP_002399512.1 CDS yqhC NC_011745.1 3585371 3586327 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(3585371..3586327) Escherichia coli ED1a 7139636 YP_002399513.1 CDS yqhD NC_011745.1 3586464 3587627 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15327949; Product type e : enzyme; alcohol dehydrogenase, NAD(P)-dependent 3586464..3587627 Escherichia coli ED1a 7143205 YP_002399514.1 CDS dkgA NC_011745.1 3587732 3588559 D methylglyoxal reductase/#-keto ester reductase; catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; also catalyzes the reduction of methylglyoxal, ethyl-2-methylacetoacetate and ethyl-acetoacetate; 2,5-diketo-D-gluconate reductase A 3587732..3588559 Escherichia coli ED1a 7143206 YP_002399515.1 CDS yqhG NC_011745.1 3588759 3589688 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3588759..3589688 Escherichia coli ED1a 7140494 YP_002399516.1 CDS insB NC_011745.1 3589623 3590126 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF2, IS1 complement(3589623..3590126) Escherichia coli ED1a 7143207 YP_002399517.1 CDS insA NC_011745.1 3590045 3590320 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF 1, IS1 complement(3590045..3590320) Escherichia coli ED1a 7141151 YP_002399518.1 CDS yqhH NC_011745.1 3590512 3590769 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; putative outer membrane lipoprotein 3590512..3590769 Escherichia coli ED1a 7141128 YP_002399519.1 CDS ygiQ NC_011745.1 3590811 3593030 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3590811..3593030) Escherichia coli ED1a 7143208 YP_002399520.1 CDS ECED1_3668 NC_011745.1 3593282 3594031 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative regulator 3593282..3594031 Escherichia coli ED1a 7139658 YP_002399521.1 CDS ECED1_3669 NC_011745.1 3594356 3595828 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Fructuronate reductase 3594356..3595828 Escherichia coli ED1a 7141779 YP_002399522.1 CDS ECED1_3670 NC_011745.1 3595825 3596841 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative L-threonine 3-dehydrogenase 3595825..3596841 Escherichia coli ED1a 7141780 YP_002399523.1 CDS ECED1_3671 NC_011745.1 3596852 3597862 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Ureidoglycolate dehydrogenase 3596852..3597862 Escherichia coli ED1a 7141781 YP_002399524.1 CDS ECED1_3672 NC_011745.1 3597935 3598918 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative c4-dicarboxylate transport system binding protein 3597935..3598918 Escherichia coli ED1a 7141782 YP_002399525.1 CDS ECED1_3673 NC_011745.1 3598960 3599442 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative TRAP-type C4-dicarboxylate transport system small permease component 3598960..3599442 Escherichia coli ED1a 7141783 YP_002399526.1 CDS ygiK NC_011745.1 3599411 3600745 D Evidence 2b : Function of strongly homologous gene; Product type t : transporter; c4-dicarboxylate permease 3599411..3600745 Escherichia coli ED1a 7141784 YP_002399527.1 CDS sufI NC_011745.1 3600816 3602228 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88314889, 1557036, 9298646; Product type r : regulator; repressor protein for FtsI complement(3600816..3602228) Escherichia coli ED1a 7139654 YP_002399528.1 CDS plsC NC_011745.1 3602303 3603040 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92212294, 1557036; Product type e : enzyme; 1-acyl-sn-glycerol-3-phosphate acyltransferase complement(3602303..3603040) Escherichia coli ED1a 7141495 YP_002399529.1 CDS ECED1_3677 NC_011745.1 3603089 3603244 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3603089..3603244) Escherichia coli ED1a 7139070 YP_002399530.1 CDS parC NC_011745.1 3603275 3605533 R decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A complement(3603275..3605533) Escherichia coli ED1a 7141785 YP_002399531.1 CDS ygiS NC_011745.1 3605671 3607278 R YgiS; uncharacterized periplasmic protein that seems to be part of a binding-protein-dependent transport system; putative binding protein complement(3605671..3607278) Escherichia coli ED1a 7144044 YP_002399532.1 CDS ygiV NC_011745.1 3607387 3607869 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator complement(3607387..3607869) Escherichia coli ED1a 7139659 YP_002399533.1 CDS ygiW NC_011745.1 3607922 3608314 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9298646; hypothetical protein complement(3607922..3608314) Escherichia coli ED1a 7139660 YP_002399534.1 CDS qseB NC_011745.1 3608466 3609125 D response regulator in two-component regulatory system with QseC; regulates FlhCD which is the master regulator for flagella and motility genes; DNA-binding transcriptional regulator QseB 3608466..3609125 Escherichia coli ED1a 7139661 YP_002399535.1 CDS qseC NC_011745.1 3609122 3610471 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21927389; Product type r : regulator; sensor protein QseC 3609122..3610471 Escherichia coli ED1a 7141242 YP_002399536.1 CDS ECED1_3685 NC_011745.1 3610855 3611592 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3610855..3611592) Escherichia coli ED1a 7139662 YP_002399537.1 CDS ECED1_3686 NC_011745.1 3611568 3612047 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3611568..3612047) Escherichia coli ED1a 7141786 YP_002399538.1 CDS mdaB NC_011745.1 3612297 3612878 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96004656, 96217538; Product type c : carrier; NADPH quinone reductase 3612297..3612878 Escherichia coli ED1a 7141787 YP_002399539.1 CDS ygiN NC_011745.1 3612909 3613223 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10493123, 9298646, 9600841, 9868784; Product type e : enzyme; quinol monooxygenase 3612909..3613223 Escherichia coli ED1a 7142218 YP_002399540.1 CDS ECED1_3689 NC_011745.1 3613268 3614155 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative bifunctional protein: transcriptional regulator and sugar phosphate isomerase complement(3613268..3614155) Escherichia coli ED1a 7139656 YP_002399541.1 CDS ECED1_3690 NC_011745.1 3614152 3615162 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative iron compound-binding protein of ABC transporter family complement(3614152..3615162) Escherichia coli ED1a 7140486 YP_002399542.1 CDS ECED1_3691 NC_011745.1 3615110 3616159 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative iron compound permease of ABC transporter family complement(3615110..3616159) Escherichia coli ED1a 7142277 YP_002399543.1 CDS ECED1_3692 NC_011745.1 3616156 3617139 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative iron compound permease of ABC transporter family complement(3616156..3617139) Escherichia coli ED1a 7142278 YP_002399544.1 CDS ECED1_3695 NC_011745.1 3618319 3620460 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative iron compound receptor 3618319..3620460 Escherichia coli ED1a 7142281 YP_002399545.1 CDS parE NC_011745.1 3620524 3622416 R decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B complement(3620524..3622416) Escherichia coli ED1a 7142282 YP_002399546.1 CDS yqiA NC_011745.1 3622445 3623026 R Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase YqiA complement(3622445..3623026) Escherichia coli ED1a 7144045 YP_002399547.1 CDS cpdA NC_011745.1 3623026 3623850 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96411758; Product type e : enzyme; cyclic 3',5'-adenosine monophosphate phosphodiesterase complement(3623026..3623850) Escherichia coli ED1a 7143209 YP_002399548.1 CDS yqiB NC_011745.1 3623875 3624297 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein complement(3623875..3624297) Escherichia coli ED1a 7142041 YP_002399549.1 CDS nudF NC_011745.1 3624298 3624927 R ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose pyrophosphatase NudF complement(3624298..3624927) Escherichia coli ED1a 7143210 YP_002399550.1 CDS tolC NC_011745.1 3625132 3626613 D trimeric outer membrane protein involved in efflux of hydrophobic/amphipathic molecules; functions with a number of efflux systems in the inner membrane to transport molecules out of the cell; outer membrane channel protein 3625132..3626613 Escherichia coli ED1a 7139941 YP_002399551.1 CDS ygiB NC_011745.1 3626857 3627432 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3626857..3627432 Escherichia coli ED1a 7141568 YP_002399552.1 CDS ygiC NC_011745.1 3627438 3628598 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 3627438..3628598 Escherichia coli ED1a 7139650 YP_002399553.1 CDS assT NC_011745.1 3629083 3630879 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8887346, 11534764; Product type e : enzyme; arylsulfate sulfotransferase 3629083..3630879 Escherichia coli ED1a 7139651 YP_002399554.1 CDS dsbA NC_011745.1 3630897 3631565 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8887346, 10600454; Product type e : enzyme; Thiol:disulfide interchange protein dsbA 3630897..3631565 Escherichia coli ED1a 7142653 YP_002399555.1 CDS ECED1_3706 NC_011745.1 3631580 3632251 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10600454; Product type pe : putative enzyme; putative disulfide oxidoreductase 3631580..3632251 Escherichia coli ED1a 7140520 YP_002399556.1 CDS zupT NC_011745.1 3632297 3633112 R seems to be involved in biofilm formation; in asymptomatic bacteriuria E. coli strains 83972 and VR50, the ygiD gene is upregulated during biofilm formation in urine; hypothetical protein complement(3632297..3633112) Escherichia coli ED1a 7142283 YP_002399557.1 CDS ygiE NC_011745.1 3633228 3634001 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11790762, 1314093; Product type t : transporter; zinc transporter ZupT 3633228..3634001 Escherichia coli ED1a 7143198 YP_002399558.1 CDS ECED1_3709 NC_011745.1 3634063 3634248 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3634063..3634248) Escherichia coli ED1a 7139652 YP_002399559.1 CDS ygiL NC_011745.1 3634804 3635367 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial protein 3634804..3635367 Escherichia coli ED1a 7142284 YP_002399560.1 CDS yqiG NC_011745.1 3635454 3637976 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative outer membrane usher protein 3635454..3637976 Escherichia coli ED1a 7139655 YP_002399561.1 CDS yqiH NC_011745.1 3637983 3638732 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative periplasmic pilin chaperone 3637983..3638732 Escherichia coli ED1a 7143212 YP_002399562.1 CDS yqiI NC_011745.1 3638729 3639778 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial adhesin 3638729..3639778 Escherichia coli ED1a 7143213 YP_002399563.1 CDS ribB NC_011745.1 3639832 3640485 R DHBP synthase; functions during riboflavin biosynthesis; 3,4-dihydroxy-2-butanone 4-phosphate synthase complement(3639832..3640485) Escherichia coli ED1a 7143214 YP_002399564.1 CDS yqiC NC_011745.1 3640799 3641158 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3640799..3641158 Escherichia coli ED1a 7140765 YP_002399565.1 CDS glgS NC_011745.1 3641193 3641393 R Involved in glycogen synthesis. May be involved in glycogen priming; glycogen synthesis protein GlgS complement(3641193..3641393) Escherichia coli ED1a 7143211 YP_002399566.1 CDS yqiJ NC_011745.1 3641663 3642292 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3641663..3642292 Escherichia coli ED1a 7143189 YP_002399567.1 CDS yqiK NC_011745.1 3642319 3643980 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3642319..3643980 Escherichia coli ED1a 7143215 YP_002399568.1 CDS rfaE NC_011745.1 3644399 3645832 R catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose; bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase complement(3644399..3645832) Escherichia coli ED1a 7141350 YP_002399569.1 CDS glnE NC_011745.1 3645880 3648720 R catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase complement(3645880..3648720) Escherichia coli ED1a 7141591 YP_002399570.1 CDS ygiF NC_011745.1 3648743 3650044 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8412694; Product type pe : putative enzyme; putative adenylate cyclase complement(3648743..3650044) Escherichia coli ED1a 7142956 YP_002399571.1 CDS ECED1_3723 NC_011745.1 3650061 3650267 R Evidence 6 : Doubtful CDS; hypothetical protein complement(3650061..3650267) Escherichia coli ED1a 7139653 YP_002399572.1 CDS htrG NC_011745.1 3650286 3650906 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11274153; Product type pr : putative regulator; putative signal transduction protein 3650286..3650906 Escherichia coli ED1a 7142285 YP_002399573.1 CDS cca NC_011745.1 3650970 3652208 D catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases; multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase 3650970..3652208 Escherichia coli ED1a 7140176 YP_002399574.1 CDS bacA NC_011745.1 3652390 3653211 R BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; undecaprenyl pyrophosphate phosphatase complement(3652390..3653211) Escherichia coli ED1a 7139312 YP_002399575.1 CDS folB NC_011745.1 3653302 3653670 R catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin; bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase complement(3653302..3653670) Escherichia coli ED1a 7140426 YP_002399576.1 CDS plsY NC_011745.1 3653775 3654392 D involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; putative glycerol-3-phosphate acyltransferase PlsY 3653775..3654392 Escherichia coli ED1a 7142156 YP_002399577.1 CDS ygiP NC_011745.1 3654405 3655337 R activates expression of genes required for L-tartrate-dependent anaerobic growth on glycerol; transcriptional activator TtdR complement(3654405..3655337) Escherichia coli ED1a 7139072 YP_002399578.1 CDS ttdA NC_011745.1 3655544 3656455 D Involved in the tartrate degradation pathway; tartrate dehydratase subunit alpha 3655544..3656455 Escherichia coli ED1a 7139657 YP_002399579.1 CDS ttdB NC_011745.1 3656452 3657057 D Involved in the tartrate degradation pathway; L(+)-tartrate dehydratase subunit beta 3656452..3657057 Escherichia coli ED1a 7140839 YP_002399580.1 CDS ygjE NC_011745.1 3657105 3658568 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative tartrate:succinate antiporter 3657105..3658568 Escherichia coli ED1a 7140840 YP_002399581.1 CDS gcp NC_011745.1 3658611 3659624 R in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; putative DNA-binding/iron metalloprotein/AP endonuclease complement(3658611..3659624) Escherichia coli ED1a 7139663 YP_002399582.1 CDS rpsU NC_011745.1 3659862 3660077 D a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 3659862..3660077 Escherichia coli ED1a 7143166 YP_002399583.1 CDS dnaG NC_011745.1 3660188 3661933 D synthesizes RNA primers at the replication forks; DNA primase 3660188..3661933 Escherichia coli ED1a 7140104 YP_002399584.1 CDS rpoD NC_011745.1 3662128 3663969 D sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria; RNA polymerase sigma factor RpoD 3662128..3663969 Escherichia coli ED1a 7140506 YP_002399585.1 CDS ygjF NC_011745.1 3664047 3664553 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20412902, 99453007, 6269063, 7567469, 8878487, 9489705; Product type e : enzyme; G/U mismatch-specific DNA glycosylase complement(3664047..3664553) Escherichia coli ED1a 7141487 YP_002399586.1 CDS yqjH NC_011745.1 3664807 3665571 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative siderophore interacting protein complement(3664807..3665571) Escherichia coli ED1a 7140578 YP_002399587.1 CDS yqjI NC_011745.1 3665859 3666482 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 3665859..3666482 Escherichia coli ED1a 7143224 YP_002399588.1 CDS aer NC_011745.1 3666589 3668109 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20015410, 9380671, 9643537, 9190831; Product type r : regulator; fused signal transducer for aerotaxis sensory component ; methyl accepting chemotaxis component complement(3666589..3668109) Escherichia coli ED1a 7143225 YP_002399589.1 CDS ygjG NC_011745.1 3668500 3669906 D catalyzes the formation of 4-aminobutyraldehyde from putrescine and 2-oxoglutarate; putrescine--2-oxoglutarate aminotransferase 3668500..3669906 Escherichia coli ED1a 7143668 YP_002399590.1 CDS ygjH NC_011745.1 3669948 3670280 R Evidence 2b : Function of strongly homologous gene; PubMedId : 11101501; hypothetical protein complement(3669948..3670280) Escherichia coli ED1a 7139665 YP_002399591.1 CDS ebgR NC_011745.1 3670499 3671482 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89128452, 2515108, 3939708; Product type r : regulator; DNA-binding transcriptional repressor EbgR 3670499..3671482 Escherichia coli ED1a 7139666 YP_002399592.1 CDS ebgA NC_011745.1 3671666 3674758 D in Escherichia coli this is the second beta-galactosidase system; cryptic beta-D-galactosidase subunit alpha 3671666..3674758 Escherichia coli ED1a 7139766 YP_002399593.1 CDS ebgC NC_011745.1 3674755 3675204 D in Escherichia coli this is the second beta-galactosidase system; cryptic beta-D-galactosidase subunit beta 3674755..3675204 Escherichia coli ED1a 7139764 YP_002399594.1 CDS ygjI NC_011745.1 3675267 3676700 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 3675267..3676700 Escherichia coli ED1a 7139765 YP_002399595.1 CDS ygjJ NC_011745.1 3676834 3677904 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3676834..3677904 Escherichia coli ED1a 7139667 YP_002399596.1 CDS ygjK NC_011745.1 3677921 3680272 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15213393; Product type pe : putative enzyme; putative glycosyl hydrolase 3677921..3680272 Escherichia coli ED1a 7139668 YP_002399597.1 CDS fadH NC_011745.1 3680498 3682516 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12840019, 89380266; Product type e : enzyme; 2,4-dienoyl-CoA reductase, NADH and FMN-linked 3680498..3682516 Escherichia coli ED1a 7139669 YP_002399598.1 CDS ygjM NC_011745.1 3682561 3682977 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(3682561..3682977) Escherichia coli ED1a 7144128 YP_002399599.1 CDS ygjO NC_011745.1 3683248 3684384 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative methyltransferase small domain complement(3683248..3684384) Escherichia coli ED1a 7139670 YP_002399600.1 CDS ygjP NC_011745.1 3684469 3684972 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative metal dependent hydrolase 3684469..3684972 Escherichia coli ED1a 7139671 YP_002399601.1 CDS ygjQ NC_011745.1 3685049 3685741 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative thioredoxin-like 3685049..3685741 Escherichia coli ED1a 7139672 YP_002399602.1 CDS ygjR NC_011745.1 3685802 3686806 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative NAD(P)-binding dehydrogenase 3685802..3686806 Escherichia coli ED1a 7139673 YP_002399603.1 CDS alx NC_011745.1 3687089 3688054 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12107143, 2108134; Product type pm : putative membrane component; hypothetical protein 3687089..3688054 Escherichia coli ED1a 7143837 YP_002399604.1 CDS sstT NC_011745.1 3688378 3689622 D involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 3688378..3689622 Escherichia coli ED1a 7143701 YP_002399605.1 CDS ygjV NC_011745.1 3689626 3690177 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(3689626..3690177) Escherichia coli ED1a 7143855 YP_002399606.1 CDS uxaA NC_011745.1 3690260 3691747 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 4570160, 83114543, 3038546; Product type e : enzyme; altronate hydrolase complement(3690260..3691747) Escherichia coli ED1a 7139467 YP_002399607.1 CDS uxaC NC_011745.1 3691762 3693174 R catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism; glucuronate isomerase complement(3691762..3693174) Escherichia coli ED1a 7139155 YP_002399608.1 CDS exuR NC_011745.1 3695085 3695861 D regulates the exuT, uxaCA and uxuRAB operons which encode genes involved in hexuronate utilization.; DNA-binding transcriptional repressor ExuR 3695085..3695861 Escherichia coli ED1a 7139836 YP_002399609.1 CDS yqjA NC_011745.1 3696206 3696868 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3696206..3696868 Escherichia coli ED1a 7139834 YP_002399610.1 CDS yqjB NC_011745.1 3696872 3697255 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11274153; hypothetical protein 3696872..3697255 Escherichia coli ED1a 7143217 YP_002399611.1 CDS yqjC NC_011745.1 3697402 3697770 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3697402..3697770 Escherichia coli ED1a 7143218 YP_002399612.1 CDS yqjD NC_011745.1 3697808 3698113 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3697808..3698113 Escherichia coli ED1a 7143219 YP_002399613.1 CDS yqjE NC_011745.1 3698116 3698520 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3698116..3698520 Escherichia coli ED1a 7143220 YP_002399614.1 CDS yqjK NC_011745.1 3698510 3698809 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3698510..3698809 Escherichia coli ED1a 7143221 YP_002399615.1 CDS yqjF NC_011745.1 3698996 3699388 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative quinol oxidase subunit 3698996..3699388 Escherichia coli ED1a 7143226 YP_002399616.1 CDS yqjG NC_011745.1 3699458 3700444 D Evidence 2b : Function of strongly homologous gene; PubMedId : 8478329; Product type e : enzyme; S-transferase 3699458..3700444 Escherichia coli ED1a 7143222 YP_002399617.1 CDS yhaH NC_011745.1 3700706 3701095 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3700706..3701095 Escherichia coli ED1a 7143223 YP_002399618.1 CDS yhaJ NC_011745.1 3701129 3702025 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(3701129..3702025) Escherichia coli ED1a 7139468 YP_002399619.1 CDS yhaK NC_011745.1 3702130 3702831 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative pirin-related protein 3702130..3702831 Escherichia coli ED1a 7139469 YP_002399620.1 CDS yhaL NC_011745.1 3702854 3703018 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3702854..3703018 Escherichia coli ED1a 7139470 YP_002399621.1 CDS yhaM NC_011745.1 3703152 3704462 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3703152..3704462) Escherichia coli ED1a 7139471 YP_002399622.1 CDS yhaO NC_011745.1 3704490 3705758 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter complement(3704490..3705758) Escherichia coli ED1a 7139472 YP_002399623.1 CDS tdcG NC_011745.1 3706096 3707460 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98143432, 9484901; Product type e : enzyme; L-serine dehydratase 3 complement(3706096..3707460) Escherichia coli ED1a 7139473 YP_002399624.1 CDS tdcF NC_011745.1 3707532 3707921 R Evidence 2b : Function of strongly homologous gene; PubMedId : 12777779, 9484901; Product type e : enzyme; hypothetical protein complement(3707532..3707921) Escherichia coli ED1a 7141528 YP_002399625.1 CDS tdcE NC_011745.1 3707935 3710229 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98143432, 9484901; Product type e : enzyme; pyruvate formate-lyase 4/2-ketobutyrate formate-lyase complement(3707935..3710229) Escherichia coli ED1a 7141527 YP_002399626.1 CDS tdcD NC_011745.1 3710263 3711483 R catalyzes the formation of propanoyl phosphate from propanoate and ATP; TdcD also has acetate kinase activities and functions in anaerobic threonine catabolism; propionate/acetate kinase complement(3710263..3711483) Escherichia coli ED1a 7141526 YP_002399627.1 CDS tdcC NC_011745.1 3711497 3712828 R involved in the import of threonine and serine in combination with the import of a proton; threonine/serine transporter TdcC complement(3711497..3712828) Escherichia coli ED1a 7141525 YP_002399628.1 CDS tdcB NC_011745.1 3712850 3713839 R catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic; threonine dehydratase complement(3712850..3713839) Escherichia coli ED1a 7141524 YP_002399629.1 CDS tdcA NC_011745.1 3713938 3714876 R regulates the tdcABCDEFG operon which is involved in amino acid degradation; DNA-binding transcriptional activator TdcA complement(3713938..3714876) Escherichia coli ED1a 7141523 YP_002399630.1 CDS tdcR NC_011745.1 3715053 3715409 D participates in controlling the expression of several structural genes for the enzyme threonine dehydratase; TdcR activates the tdcABCDEFG operon; DNA-binding transcriptional activator TdcR 3715053..3715409 Escherichia coli ED1a 7141522 YP_002399631.1 CDS garK NC_011745.1 3716375 3717601 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20225875, 69151449, 9772162; Product type e : enzyme; glycerate kinase I complement(3716375..3717601) Escherichia coli ED1a 7141441 YP_002399632.1 CDS garR NC_011745.1 3717617 3718507 R catalyzes the reduction of tartronate semialdehyde to glycerate; tartronate semialdehyde reductase complement(3717617..3718507) Escherichia coli ED1a 7143160 YP_002399633.1 CDS garL NC_011745.1 3718537 3719304 R cleaves 5-dehydro-4-deoxy-glucarate and 2-dehydro-3-deoxy-D-glucarate; alpha-dehydro-beta-deoxy-D-glucarate aldolase complement(3718537..3719304) Escherichia coli ED1a 7143163 YP_002399634.1 CDS garD NC_011745.1 3721049 3722620 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20225875, 66096392, 81027430, 9772162, 10762278, 2407727; Product type e : enzyme; (D)-galactarate dehydrogenase 3721049..3722620 Escherichia coli ED1a 7143162 YP_002399635.1 CDS sohA NC_011745.1 3722769 3723104 D SohA; PrlF; involved in protein secretion; when overproduced or mutated, it induces growth defect and increased export of a reporter protein; a PrlF mutation induces the activity of the Lon protease, and a Lon-deficient strain suppresses the phenotype conferred by the PrlF mutation; putative regulator PrlF 3722769..3723104 Escherichia coli ED1a 7143159 YP_002399636.1 CDS yhaV NC_011745.1 3723104 3723568 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3723104..3723568 Escherichia coli ED1a 7143817 YP_002399637.1 CDS agaR NC_011745.1 3723623 3724432 R transcriptional repressor for the agaZVWA and agaSYBCDI operons; DNA-binding transcriptional regulator AgaR complement(3723623..3724432) Escherichia coli ED1a 7139474 YP_002399638.1 CDS kbaZ NC_011745.1 3724681 3725961 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11976750, 20392444, 10931310, 8932697; Product type e : enzyme; tagatose 6-phosphate aldolase 1, kbaZ subunit 3724681..3725961 Escherichia coli ED1a 7143676 YP_002399639.1 CDS agaV NC_011745.1 3725984 3726457 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake;involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIB 3725984..3726457 Escherichia coli ED1a 7142487 YP_002399640.1 CDS ECED1_3796 NC_011745.1 3726468 3727247 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative enzyme IIC component of PTS 3726468..3727247 Escherichia coli ED1a 7143678 YP_002399641.1 CDS ECED1_3797 NC_011745.1 3727231 3728115 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative hexose/hexosamine family PTS permease IID component 3727231..3728115 Escherichia coli ED1a 7142286 YP_002399642.1 CDS ECED1_3798 NC_011745.1 3728133 3728567 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphotransferase system enzyme subunit (N-acetyl-galactosamine / galactosamine PTS system enzyme IIA component) 3728133..3728567 Escherichia coli ED1a 7142287 YP_002399643.1 CDS agaA NC_011745.1 3728543 3729697 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; N-acetylglucosamine-6-phosphate deacetylase 3728543..3729697 Escherichia coli ED1a 7142288 YP_002399644.1 CDS agaS NC_011745.1 3730048 3731202 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689210, 9697096, 14731281, 8932697; Product type e : enzyme; tagatose-6-phosphate ketose/aldose isomerase 3730048..3731202 Escherichia coli ED1a 7143671 YP_002399645.1 CDS kbaY NC_011745.1 3731215 3732075 D catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway; tagatose-bisphosphate aldolase 3731215..3732075 Escherichia coli ED1a 7143677 YP_002399646.1 CDS agaB NC_011745.1 3732242 3732718 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIB 3732242..3732718 Escherichia coli ED1a 7142486 YP_002399647.1 CDS agaC NC_011745.1 3732757 3733560 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane;protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIC 3732757..3733560 Escherichia coli ED1a 7143672 YP_002399648.1 CDS agaD NC_011745.1 3733550 3734341 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IID 3733550..3734341 Escherichia coli ED1a 7143673 YP_002399649.1 CDS agaI NC_011745.1 3734342 3735109 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10931310; Product type e : enzyme; galactosamine-6-phosphate isomerase 3734342..3735109 Escherichia coli ED1a 7143674 YP_002399650.1 CDS yraL NC_011745.1 3735159 3736022 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative methyltransferase complement(3735159..3736022) Escherichia coli ED1a 7143675 YP_002399651.1 CDS yraM NC_011745.1 3736087 3738123 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3736087..3738123 Escherichia coli ED1a 7143227 YP_002399652.1 CDS yraN NC_011745.1 3738081 3738476 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3738081..3738476 Escherichia coli ED1a 7143228 YP_002399653.1 CDS yraO NC_011745.1 3738496 3739086 D Required for the timely initiation of chromosomal replication via direct interactions with the dnaA initiator protein; DnaA initiator-associating protein DiaA 3738496..3739086 Escherichia coli ED1a 7143229 YP_002399654.1 CDS ecfH NC_011745.1 3739096 3739671 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11274153; hypothetical protein 3739096..3739671 Escherichia coli ED1a 7143230 YP_002399655.1 CDS yraQ NC_011745.1 3739784 3740824 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative permease complement(3739784..3740824) Escherichia coli ED1a 7139767 YP_002399656.1 CDS yraR NC_011745.1 3740897 3741532 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative nucleoside-diphosphate-sugar epimerase complement(3740897..3741532) Escherichia coli ED1a 7143231 YP_002399657.1 CDS yhbO NC_011745.1 3741660 3742178 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative intracellular protease 3741660..3742178 Escherichia coli ED1a 7143232 YP_002399658.1 CDS yhbP NC_011745.1 3742158 3742601 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3742158..3742601) Escherichia coli ED1a 7139479 YP_002399659.1 CDS yhbQ NC_011745.1 3742652 3742954 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; GIY-YIG nuclease superfamily protein 3742652..3742954 Escherichia coli ED1a 7139480 YP_002399660.1 CDS yhbS NC_011745.1 3742941 3743444 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acyl-CoA N-acyltransferase domain-containing acyltransferase complement(3742941..3743444) Escherichia coli ED1a 7139481 YP_002399661.1 CDS yhbT NC_011745.1 3743438 3743962 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative lipid carrier protein complement(3743438..3743962) Escherichia coli ED1a 7139482 YP_002399662.1 CDS yhbU NC_011745.1 3744171 3745166 D Evidence 2b : Function of strongly homologous gene; PubMedId : 10206698; Product type e : enzyme; collagenase-like peptidase 3744171..3745166 Escherichia coli ED1a 7139483 YP_002399663.1 CDS yhbV NC_011745.1 3745175 3746053 D Evidence 2b : Function of strongly homologous gene; PubMedId : 10206698; Product type e : enzyme; protease 3745175..3746053 Escherichia coli ED1a 7139484 YP_002399664.1 CDS yhbW NC_011745.1 3746134 3747141 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 3746134..3747141 Escherichia coli ED1a 7139485 YP_002399665.1 CDS mtr NC_011745.1 3747259 3748503 R tryptophan transporter of high affinity; tryptophan permease complement(3747259..3748503) Escherichia coli ED1a 7139486 YP_002399666.1 CDS deaD NC_011745.1 3748657 3750546 R participates in the assembly of the large subunit of the ribosome; plays a key role in optimal cell growth at low temperature and is required for normal cell division; ATP-dependent RNA helicase DeaD complement(3748657..3750546) Escherichia coli ED1a 7139041 YP_002399667.1 CDS nlpI NC_011745.1 3750726 3751610 R lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing; lipoprotein NlpI complement(3750726..3751610) Escherichia coli ED1a 7143082 YP_002399668.1 CDS pnp NC_011745.1 3751719 3753923 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87083499, 91198209, 99234021, 99340204, 2432069, 3005122, 6382163, 9008164, 9298646; Product type e : enzyme; polynucleotide phosphorylase/polyadenylase complement(3751719..3753923) Escherichia coli ED1a 7140402 YP_002399669.1 CDS rpsO NC_011745.1 3754101 3754370 R primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 complement(3754101..3754370) Escherichia coli ED1a 7143838 YP_002399670.1 CDS truB NC_011745.1 3754519 3755463 R catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B complement(3754519..3755463) Escherichia coli ED1a 7140098 YP_002399671.1 CDS rbfA NC_011745.1 3755463 3755864 R associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A complement(3755463..3755864) Escherichia coli ED1a 7140828 YP_002399672.1 CDS infB NC_011745.1 3756028 3758700 R Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 complement(3756028..3758700) Escherichia coli ED1a 7141254 YP_002399673.1 CDS nusA NC_011745.1 3758725 3760212 R modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA complement(3758725..3760212) Escherichia coli ED1a 7141110 YP_002399674.1 CDS yhbC NC_011745.1 3760240 3760692 R in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein complement(3760240..3760692) Escherichia coli ED1a 7139959 YP_002399675.1 CDS argG NC_011745.1 3761323 3762666 D catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis; argininosuccinate synthase 3761323..3762666 Escherichia coli ED1a 7140611 YP_002399676.1 CDS yhbX NC_011745.1 3762674 3764299 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase, inner membrane complement(3762674..3764299) Escherichia coli ED1a 7142614 YP_002399677.1 CDS secG NC_011745.1 3764857 3765189 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20194819, 21125563, 9020118, 94074540, 9564033, 9644254, 9829959, 99298179, 7556084, 8034620, 8045257, 8244950, 8253068; Product type t : transporter; preprotein translocase subunit SecG complement(3764857..3765189) Escherichia coli ED1a 7140610 YP_002399678.1 CDS glmM NC_011745.1 3765417 3766754 R catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase complement(3765417..3766754) Escherichia coli ED1a 7141390 YP_002399679.1 CDS folP NC_011745.1 3766747 3767595 R catalyzes the formation of dihydropteroate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate; dihydropteroate synthase complement(3766747..3767595) Escherichia coli ED1a 7143192 YP_002399680.1 CDS hflB NC_011745.1 3767685 3769619 R inner membrane metalloprotease; may be involved in degradation of aberrant cytoplasmic and membrane proteins; ATP-dependent metalloprotease complement(3767685..3769619) Escherichia coli ED1a 7142162 YP_002399681.1 CDS rrmJ NC_011745.1 3769719 3770348 R Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit; 23S rRNA methyltransferase J complement(3769719..3770348) Escherichia coli ED1a 7142191 YP_002399682.1 CDS yhbY NC_011745.1 3770474 3770767 D RNA binding protein found associated to pre-50S subunit of the ribosome; putative role in ribosome assembly; necessary for optimal growth but not cell viability; RNA-binding protein YhbY 3770474..3770767 Escherichia coli ED1a 7140107 YP_002399683.1 CDS greA NC_011745.1 3770923 3771399 R necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA complement(3770923..3771399) Escherichia coli ED1a 7139488 YP_002399684.1 CDS dacB NC_011745.1 3771647 3773080 D penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase/endopeptidase 3771647..3773080 Escherichia coli ED1a 7143019 YP_002399685.1 CDS obgE NC_011745.1 3773121 3774293 R essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE complement(3773121..3774293) Escherichia coli ED1a 7143053 YP_002399686.1 CDS yhbE NC_011745.1 3774309 3775274 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(3774309..3775274) Escherichia coli ED1a 7139964 YP_002399687.1 CDS rpmA NC_011745.1 3775401 3775658 R involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 complement(3775401..3775658) Escherichia coli ED1a 7139476 YP_002399688.1 CDS rplU NC_011745.1 3775679 3775990 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91088242, 94146411, 10094780, 387076, 8312607; Product type s : structure; 50S ribosomal protein L21 complement(3775679..3775990) Escherichia coli ED1a 7141475 YP_002399689.1 CDS ispB NC_011745.1 3776249 3777220 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94311902, 97284515, 2670911, 8037730, 8312607; Product type e : enzyme; octaprenyl diphosphate synthase 3776249..3777220 Escherichia coli ED1a 7141470 YP_002399690.1 CDS sfsB NC_011745.1 3777454 3777732 D activator of maltose metabolism genes; DNA-binding transcriptional regulator Nlp 3777454..3777732 Escherichia coli ED1a 7142463 YP_002399691.1 CDS murA NC_011745.1 3777780 3779039 R adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase complement(3777780..3779039) Escherichia coli ED1a 7141405 YP_002399692.1 CDS yrbA NC_011745.1 3779094 3779348 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(3779094..3779348) Escherichia coli ED1a 7139045 YP_002399693.1 CDS yrbB NC_011745.1 3779508 3779801 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3779508..3779801) Escherichia coli ED1a 7143233 YP_002399694.1 CDS yrbC NC_011745.1 3779801 3780436 R Evidence 2b : Function of strongly homologous gene; PubMedId : 9658016; Product type t : transporter; toluene ABC transporter membrane protein complement(3779801..3780436) Escherichia coli ED1a 7143234 YP_002399695.1 CDS yrbD NC_011745.1 3780455 3781006 R Evidence 2b : Function of strongly homologous gene; PubMedId : 9658016; Product type t : transporter; toluene ABC transporter membrane protein complement(3780455..3781006) Escherichia coli ED1a 7143235 YP_002399696.1 CDS yrbE NC_011745.1 3781011 3781793 R Evidence 2b : Function of strongly homologous gene; PubMedId : 9658016; Product type t : transporter; toluene ABC transporter membrane protein complement(3781011..3781793) Escherichia coli ED1a 7143236 YP_002399697.1 CDS yrbF NC_011745.1 3781801 3782610 R ATP-binding subunit of a putative ABC toluene efflux transporter; putative ABC transporter ATP-binding protein YrbF complement(3781801..3782610) Escherichia coli ED1a 7143237 YP_002399698.1 CDS yrbG NC_011745.1 3782820 3783797 D YrbG; inner membrane protein involved in cell envelope integrity; putative sodium ion/calcium ion exchanger; in E. coli it is non essential for cell viability; member of the YRBG family of cation/Ca2+ exchangers; putative calcium/sodium:proton antiporter 3782820..3783797 Escherichia coli ED1a 7143238 YP_002399699.1 CDS kdsD NC_011745.1 3783811 3784797 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12805358; Product type e : enzyme; D-arabinose 5-phosphate isomerase 3783811..3784797 Escherichia coli ED1a 7143239 YP_002399700.1 CDS kdsC NC_011745.1 3784818 3785384 D forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase 3784818..3785384 Escherichia coli ED1a 7142501 YP_002399701.1 CDS yrbK NC_011745.1 3785381 3785956 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3785381..3785956 Escherichia coli ED1a 7142500 YP_002399702.1 CDS lptA NC_011745.1 3785925 3786482 D LptA; periplasmic binding protein part of a putative ABC superfamily of uptake transporters; interacts with LptB protein, the ATP binding component of the uptake system; lipopolysaccharide transport periplasmic protein LptA 3785925..3786482 Escherichia coli ED1a 7143240 YP_002399703.1 CDS lptB NC_011745.1 3786489 3787214 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7876255, 9298646, 17056748; Product type pt : putative transporter; putative ABC transporter ATP-binding protein YhbG 3786489..3787214 Escherichia coli ED1a 7141915 YP_002399704.1 CDS rpoN NC_011745.1 3787262 3788695 D sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen; RNA polymerase factor sigma-54 3787262..3788695 Escherichia coli ED1a 7141916 YP_002399705.1 CDS yhbH NC_011745.1 3788718 3789005 D YhbH; resting ribosome-binding protein involved in ribosome stabilization and preservation in stationary phase; binds specifically 100S ribosomes (an inactive ribosome product of a 70S ribosome dimerization); seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing; putative sigma(54) modulation protein 3788718..3789005 Escherichia coli ED1a 7141490 YP_002399706.1 CDS ptsN NC_011745.1 3789123 3789614 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88212176, 90136533, 90274974, 95020584, 95181483, 7876255, 8025669, 8444818, 9636714; Product type t : transporter; PTS system transporter subunit IIA-like nitrogen-regulatory protein PtsN 3789123..3789614 Escherichia coli ED1a 7139477 YP_002399707.1 CDS yhbJ NC_011745.1 3789660 3790514 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3789660..3790514 Escherichia coli ED1a 7141211 YP_002399708.1 CDS npr NC_011745.1 3790511 3790783 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10473571, 95181483, 7876255, 8025669; Product type t : transporter; phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) 3790511..3790783 Escherichia coli ED1a 7139478 YP_002399709.1 CDS yrbL NC_011745.1 3790997 3791629 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 89083480; hypothetical protein 3790997..3791629 Escherichia coli ED1a 7139756 YP_002399710.1 CDS mtgA NC_011745.1 3791626 3792354 R glycosyltransferase; polymerizes glycan strands in the peptidoglycan; monofunctional biosynthetic peptidoglycan transglycosylase complement(3791626..3792354) Escherichia coli ED1a 7143241 YP_002399711.1 CDS elbB NC_011745.1 3792351 3793004 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92246944, 98269038, 1575737, 9603997; Product type pe : putative enzyme; isoprenoid biosynthesis protein with amidotransferase-like domain complement(3792351..3793004) Escherichia coli ED1a 7139037 YP_002399712.1 CDS arcB NC_011745.1 3793234 3795570 R sensor-regulator protein which regulates the expression of many genes in response to respiratory growth conditions including anaerobic repression of the arc modulon; hybrid sensory histidine kinase in two-component regulatory system with ArcA; aerobic respiration control sensor protein ArcB complement(3793234..3795570) Escherichia coli ED1a 7141351 YP_002399713.1 CDS yhcC NC_011745.1 3795666 3796595 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Fe-S oxidoreductase complement(3795666..3796595) Escherichia coli ED1a 7142606 YP_002399714.1 CDS gltB NC_011745.1 3797177 3801730 D catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate; glutamate synthase subunit alpha 3797177..3801730 Escherichia coli ED1a 7139490 YP_002399715.1 CDS gltD NC_011745.1 3801743 3803161 D glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; glutamate synthase subunit beta 3801743..3803161 Escherichia coli ED1a 7142979 YP_002399716.1 CDS yhcH NC_011745.1 3803229 3803693 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3803229..3803693) Escherichia coli ED1a 7142980 YP_002399717.1 CDS nanK NC_011745.1 3803690 3804565 R catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein; N-acetylmannosamine kinase complement(3803690..3804565) Escherichia coli ED1a 7139491 YP_002399718.1 CDS nanE NC_011745.1 3804562 3805251 R Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase complement(3804562..3805251) Escherichia coli ED1a 7140345 YP_002399719.1 CDS nanT NC_011745.1 3805299 3806789 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96011396, 9864311, 7592358; Product type t : transporter; putative sialic acid transporter complement(3805299..3806789) Escherichia coli ED1a 7140343 YP_002399720.1 CDS nanA NC_011745.1 3806898 3807791 R catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid; N-acetylneuraminate lyase complement(3806898..3807791) Escherichia coli ED1a 7140349 YP_002399721.1 CDS nanR NC_011745.1 3807913 3808704 R Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization; transcriptional regulator NanR complement(3807913..3808704) Escherichia coli ED1a 7140342 YP_002399722.1 CDS sspB NC_011745.1 3808812 3809309 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12445774, 94293773, 1721886, 3029697, 8022275; Product type f : factor; ClpXP protease specificity-enhancing factor complement(3808812..3809309) Escherichia coli ED1a 7140347 YP_002399723.1 CDS sspA NC_011745.1 3809315 3809953 R transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation; stringent starvation protein A complement(3809315..3809953) Escherichia coli ED1a 7143852 YP_002399724.1 CDS rpsI NC_011745.1 3810348 3810740 R forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 complement(3810348..3810740) Escherichia coli ED1a 7143851 YP_002399725.1 CDS rplM NC_011745.1 3810756 3811184 R in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 complement(3810756..3811184) Escherichia coli ED1a 7140092 YP_002399726.1 CDS yhcM NC_011745.1 3811404 3812531 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3811404..3812531) Escherichia coli ED1a 7141462 YP_002399727.1 CDS yhcB NC_011745.1 3812725 3813123 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16079137; Product type pe : putative enzyme; cytochrome d ubiquinol oxidase subunit III 3812725..3813123 Escherichia coli ED1a 7139492 YP_002399728.1 CDS degQ NC_011745.1 3813277 3814644 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8830688, 96165272, 8576051, 8576052, 9740056; Product type e : enzyme; serine endoprotease 3813277..3814644 Escherichia coli ED1a 7139489 YP_002399729.1 CDS degS NC_011745.1 3814734 3815801 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15137941, 15225661, 21352996, 96165272, 99431977, 3322223, 8576051; Product type e : enzyme; serine endoprotease 3814734..3815801 Escherichia coli ED1a 7143087 YP_002399730.1 CDS mdh NC_011745.1 3815864 3816802 R oxidizes malate to oxaloacetate; malate dehydrogenase complement(3815864..3816802) Escherichia coli ED1a 7143088 YP_002399731.1 CDS argR NC_011745.1 3817237 3817707 D regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor 3817237..3817707 Escherichia coli ED1a 7142219 YP_002399732.1 CDS yhcN NC_011745.1 3818071 3818334 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3818071..3818334 Escherichia coli ED1a 7142619 YP_002399733.1 CDS yhcO NC_011745.1 3818389 3818661 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative barnase inhibitor complement(3818389..3818661) Escherichia coli ED1a 7139493 YP_002399734.1 CDS aaeB NC_011745.1 3818753 3820720 R with AaeA forms an efflux pump whose substrates are p-hydroxybenzoic acid 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeB complement(3818753..3820720) Escherichia coli ED1a 7139494 YP_002399735.1 CDS aaeA NC_011745.1 3820726 3821658 R with AaeB forms an efflux pump whose substrates are p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeA complement(3820726..3821658) Escherichia coli ED1a 7140642 YP_002399736.1 CDS aaeX NC_011745.1 3821666 3821869 R membrane protein AaeX; the gene is a member of the aaeXAB operon; hypothetical protein complement(3821666..3821869) Escherichia coli ED1a 7140641 YP_002399737.1 CDS aaeR NC_011745.1 3822052 3822981 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15489430; Product type r : regulator; putative DNA-binding transcriptional regulator 3822052..3822981 Escherichia coli ED1a 7140644 YP_002399738.1 CDS tldD NC_011745.1 3823109 3824554 R responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase; degrades the E. coli plasmid F-encoded CcdA; protease TldD complement(3823109..3824554) Escherichia coli ED1a 7140643 YP_002399739.1 CDS yhdP NC_011745.1 3824710 3828510 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10960106; Product type pm : putative membrane component; hypothetical protein complement(3824710..3828510) Escherichia coli ED1a 7141561 YP_002399740.1 CDS rng NC_011745.1 3828578 3830047 R involved in the processing of the 5'end of 16S rRNA; ribonuclease G complement(3828578..3830047) Escherichia coli ED1a 7139500 YP_002399741.1 CDS yhdE NC_011745.1 3830037 3830630 R Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein complement(3830037..3830630) Escherichia coli ED1a 7141436 YP_002399742.1 CDS mreD NC_011745.1 3830639 3831127 R part of cell wall structural complex MreBCD; transmembrane component; rod shape-determining protein MreD complement(3830639..3831127) Escherichia coli ED1a 7139495 YP_002399743.1 CDS ECED1_3899 NC_011745.1 3831111 3831242 R Evidence 6 : Doubtful CDS; hypothetical protein complement(3831111..3831242) Escherichia coli ED1a 7139028 YP_002399744.1 CDS mreC NC_011745.1 3831127 3832230 R in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC complement(3831127..3832230) Escherichia coli ED1a 7142289 YP_002399745.1 CDS mreB NC_011745.1 3832296 3833339 R functions in MreBCD complex in some organisms; rod shape-determining protein MreB complement(3832296..3833339) Escherichia coli ED1a 7139027 YP_002399746.1 CDS ECED1_3902 NC_011745.1 3833447 3833635 D Evidence 6 : Doubtful CDS; hypothetical protein 3833447..3833635 Escherichia coli ED1a 7139026 YP_002399747.1 CDS csrD NC_011745.1 3833644 3835584 R regulates the degradation of the small RNAs CsrB and CsrC; may function to targate RNase E to specific RNA molecules; regulatory protein CsrD complement(3833644..3835584) Escherichia coli ED1a 7142290 YP_002399748.1 CDS yhdH NC_011745.1 3835736 3836710 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase, Zn-dependent and NAD(P)-binding 3835736..3836710 Escherichia coli ED1a 7142078 YP_002399749.1 CDS ECED1_3905 NC_011745.1 3836747 3837010 D Evidence 6 : Doubtful CDS; hypothetical protein 3836747..3837010 Escherichia coli ED1a 7139496 YP_002399750.1 CDS accB NC_011745.1 3837690 3838160 D composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 3837690..3838160 Escherichia coli ED1a 7142291 YP_002399751.1 CDS accC NC_011745.1 3838171 3839520 D an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 3838171..3839520 Escherichia coli ED1a 7143633 YP_002399752.1 CDS ECED1_3908 NC_011745.1 3839612 3840658 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3839612..3840658) Escherichia coli ED1a 7143634 YP_002399753.1 CDS ECED1_3909 NC_011745.1 3840655 3841617 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative carbohydrate kinase complement(3840655..3841617) Escherichia coli ED1a 7142292 YP_002399754.1 CDS ECED1_3910 NC_011745.1 3841639 3842628 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter membrane protein complement(3841639..3842628) Escherichia coli ED1a 7142293 YP_002399755.1 CDS ECED1_3911 NC_011745.1 3842629 3844158 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter ATP-binding protein complement(3842629..3844158) Escherichia coli ED1a 7142294 YP_002399756.1 CDS ECED1_3912 NC_011745.1 3844189 3845085 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC-type sugar transport system, periplasmic component complement(3844189..3845085) Escherichia coli ED1a 7142295 YP_002399757.1 CDS gatY NC_011745.1 3845115 3845969 R catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway; tagatose-bisphosphate aldolase complement(3845115..3845969) Escherichia coli ED1a 7142296 YP_002399758.1 CDS ECED1_3914 NC_011745.1 3846311 3847141 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DEOR-type transcriptional regulator 3846311..3847141 Escherichia coli ED1a 7142297 YP_002399759.1 CDS ECED1_3915 NC_011745.1 3847098 3848108 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative pfkB family carbohydrate kinase 3847098..3848108 Escherichia coli ED1a 7142298 YP_002399760.1 CDS yhdT NC_011745.1 3848201 3848443 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3848201..3848443 Escherichia coli ED1a 7142299 YP_002399761.1 CDS panF NC_011745.1 3848433 3849884 D mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase; sodium/panthothenate symporter 3848433..3849884 Escherichia coli ED1a 7139501 YP_002399762.1 CDS prmA NC_011745.1 3849896 3850777 D methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; ribosomal protein L11 methyltransferase 3849896..3850777 Escherichia coli ED1a 7144043 YP_002399763.1 CDS dusB NC_011745.1 3851106 3852071 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 22095566, 1459953, 1547773, 2835774, 2837762, 8226664; Product type e : enzyme; tRNA-dihydrouridine synthase B 3851106..3852071 Escherichia coli ED1a 7139124 YP_002399764.1 CDS fis NC_011745.1 3852097 3852393 D Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription; DNA-binding protein Fis 3852097..3852393 Escherichia coli ED1a 7140532 YP_002399765.1 CDS yhdJ NC_011745.1 3852479 3853363 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15028690, 9073062; Product type e : enzyme; putative methyltransferase 3852479..3853363 Escherichia coli ED1a 7144187 YP_002399766.1 CDS yhdU NC_011745.1 3853447 3853626 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3853447..3853626 Escherichia coli ED1a 7139497 YP_002399767.1 CDS envR NC_011745.1 3853629 3854291 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8203018, 11257026, 8407802, 1720861; Product type r : regulator; DNA-binding transcriptional regulator EnvR complement(3853629..3854291) Escherichia coli ED1a 7139502 YP_002399768.1 CDS acrE NC_011745.1 3854690 3855847 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94012493, 1720861; Product type lp : lipoprotein; cytoplasmic membrane lipoprotein 3854690..3855847 Escherichia coli ED1a 7139801 YP_002399769.1 CDS acrF NC_011745.1 3855859 3858963 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94262163, 99449638, 1720861, 8407802; Product type t : transporter; multidrug efflux system protein 3855859..3858963 Escherichia coli ED1a 7143652 YP_002399770.1 CDS ECED1_3926 NC_011745.1 3859001 3859189 D Evidence 6 : Doubtful CDS; hypothetical protein 3859001..3859189 Escherichia coli ED1a 7143653 YP_002399771.1 CDS ECED1_3927 NC_011745.1 3859095 3859604 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase IS605 family, IS200 group 3859095..3859604 Escherichia coli ED1a 7142300 YP_002399772.1 CDS yhdV NC_011745.1 3859928 3860149 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3859928..3860149 Escherichia coli ED1a 7142301 YP_002399773.1 CDS ECED1_3929 NC_011745.1 3860375 3860551 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3860375..3860551 Escherichia coli ED1a 7139503 YP_002399774.1 CDS aapJ NC_011745.1 3860688 3861605 D Evidence 2b : Function of strongly homologous gene; PubMedId : 8898392; Product type t : transporter; amino-acid ABC transporter periplasmic-binding protein 3860688..3861605 Escherichia coli ED1a 7142302 YP_002399775.1 CDS aapQ NC_011745.1 3861673 3862854 D Evidence 2b : Function of strongly homologous gene; PubMedId : 8898392; Product type t : transporter; amino-acid ABC transporter membrane protein 3861673..3862854 Escherichia coli ED1a 7140645 YP_002399776.1 CDS aapM NC_011745.1 3862864 3863967 D Evidence 2b : Function of strongly homologous gene; PubMedId : 8898392; Product type t : transporter; amino-acid ABC transporter membrane protein 3862864..3863967 Escherichia coli ED1a 7140648 YP_002399777.1 CDS aapP NC_011745.1 3863975 3864733 D Evidence 2b : Function of strongly homologous gene; PubMedId : 8809753, 8898392; Product type t : transporter; amino-acid ABC transporter ATP-binding protein 3863975..3864733 Escherichia coli ED1a 7140646 YP_002399778.1 CDS yrdA NC_011745.1 3870288 3871169 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3870288..3871169 Escherichia coli ED1a 7142816 YP_002399779.1 CDS yrdB NC_011745.1 3871145 3871402 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3871145..3871402) Escherichia coli ED1a 7143242 YP_002399780.1 CDS aroE NC_011745.1 3871399 3872217 R AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase complement(3871399..3872217) Escherichia coli ED1a 7143243 YP_002399781.1 CDS yrdC NC_011745.1 3872222 3872794 R RimN; YrdC; required for maturation of 16s RNA; binds preferentially double stranded RNA; putative ribosome maturation factor complement(3872222..3872794) Escherichia coli ED1a 7142627 YP_002399782.1 CDS yrdD NC_011745.1 3872799 3873341 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative DNA topoisomerase complement(3872799..3873341) Escherichia coli ED1a 7143244 YP_002399783.1 CDS smg NC_011745.1 3873370 3873843 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8432722; hypothetical protein complement(3873370..3873843) Escherichia coli ED1a 7143245 YP_002399784.1 CDS smf NC_011745.1 3873815 3874939 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8112305, 8432722; DNA protecting protein DprA complement(3873815..3874939) Escherichia coli ED1a 7143810 YP_002399785.1 CDS def NC_011745.1 3875069 3875578 D cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 3875069..3875578 Escherichia coli ED1a 7143809 YP_002399786.1 CDS fmt NC_011745.1 3875593 3876540 D modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 3875593..3876540 Escherichia coli ED1a 7143085 YP_002399787.1 CDS rsmB NC_011745.1 3876592 3877881 D catalyzes the methylation of cytosine at position 967 (m5C967) of 16S rRNA; SAM-dependent methyltransferase; 16S rRNA methyltransferase B 3876592..3877881 Escherichia coli ED1a 7142152 YP_002399788.1 CDS trkA NC_011745.1 3877903 3879279 D involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane component 3877903..3879279 Escherichia coli ED1a 7140114 YP_002399789.1 CDS mscL NC_011745.1 3879409 3879822 D forms homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel 3879409..3879822 Escherichia coli ED1a 7140810 YP_002399790.1 CDS yhdL NC_011745.1 3879819 3880037 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3879819..3880037) Escherichia coli ED1a 7139032 YP_002399791.1 CDS zntR NC_011745.1 3880093 3880518 R mediates expression of the zinc export protein ZntA in response to high levels of zinc; member of MerR family of transcriptional regulators; zinc-responsive transcriptional regulator complement(3880093..3880518) Escherichia coli ED1a 7139498 YP_002399792.1 CDS yhdN NC_011745.1 3880529 3880897 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3880529..3880897) Escherichia coli ED1a 7143277 YP_002399793.1 CDS rplQ NC_011745.1 3881003 3881386 R is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 complement(3881003..3881386) Escherichia coli ED1a 7139499 YP_002399794.1 CDS rpoA NC_011745.1 3881427 3882416 R catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha complement(3881427..3882416) Escherichia coli ED1a 7141466 YP_002399795.1 CDS rpsD NC_011745.1 3882442 3883062 R primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 complement(3882442..3883062) Escherichia coli ED1a 7141484 YP_002399796.1 CDS rpsK NC_011745.1 3883096 3883485 R located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 complement(3883096..3883485) Escherichia coli ED1a 7140087 YP_002399797.1 CDS rpsM NC_011745.1 3883502 3883858 R located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 complement(3883502..3883858) Escherichia coli ED1a 7140094 YP_002399798.1 CDS secY NC_011745.1 3884153 3885484 R forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY complement(3884153..3885484) Escherichia coli ED1a 7140096 YP_002399799.1 CDS rplO NC_011745.1 3885492 3885926 R late assembly protein; 50S ribosomal protein L15 complement(3885492..3885926) Escherichia coli ED1a 7141392 YP_002399800.1 CDS rpmD NC_011745.1 3885930 3886109 R L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 complement(3885930..3886109) Escherichia coli ED1a 7141464 YP_002399801.1 CDS rpsE NC_011745.1 3886113 3886616 R located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 complement(3886113..3886616) Escherichia coli ED1a 7141478 YP_002399802.1 CDS rplR NC_011745.1 3886631 3886984 R binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 complement(3886631..3886984) Escherichia coli ED1a 7140088 YP_002399803.1 CDS rplF NC_011745.1 3886994 3887527 R ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 complement(3886994..3887527) Escherichia coli ED1a 7141467 YP_002399804.1 CDS rpsH NC_011745.1 3887540 3887932 R binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 complement(3887540..3887932) Escherichia coli ED1a 7141457 YP_002399805.1 CDS rpsN NC_011745.1 3887966 3888271 R located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 complement(3887966..3888271) Escherichia coli ED1a 7140091 YP_002399806.1 CDS rplE NC_011745.1 3888286 3888825 R part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 complement(3888286..3888825) Escherichia coli ED1a 7140097 YP_002399807.1 CDS rplX NC_011745.1 3888840 3889154 R assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 complement(3888840..3889154) Escherichia coli ED1a 7141456 YP_002399808.1 CDS rplN NC_011745.1 3889165 3889536 R binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 complement(3889165..3889536) Escherichia coli ED1a 7141473 YP_002399809.1 CDS rpsQ NC_011745.1 3889701 3889955 R primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 complement(3889701..3889955) Escherichia coli ED1a 7141463 YP_002399810.1 CDS rpmC NC_011745.1 3889955 3890146 R one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 complement(3889955..3890146) Escherichia coli ED1a 7140100 YP_002399811.1 CDS rplP NC_011745.1 3890146 3890556 R located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 complement(3890146..3890556) Escherichia coli ED1a 7141477 YP_002399812.1 CDS rpsC NC_011745.1 3890569 3891270 R forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 complement(3890569..3891270) Escherichia coli ED1a 7141465 YP_002399813.1 CDS rplV NC_011745.1 3891288 3891620 R binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 complement(3891288..3891620) Escherichia coli ED1a 7140086 YP_002399814.1 CDS rpsS NC_011745.1 3891635 3891913 R protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 complement(3891635..3891913) Escherichia coli ED1a 7141471 YP_002399815.1 CDS rplB NC_011745.1 3891930 3892751 R one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 complement(3891930..3892751) Escherichia coli ED1a 7140102 YP_002399816.1 CDS rplW NC_011745.1 3892769 3893071 R binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 complement(3892769..3893071) Escherichia coli ED1a 7141453 YP_002399817.1 CDS rplD NC_011745.1 3893068 3893673 R L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 complement(3893068..3893673) Escherichia coli ED1a 7141472 YP_002399818.1 CDS rplC NC_011745.1 3893684 3894313 R binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 complement(3893684..3894313) Escherichia coli ED1a 7141455 YP_002399819.1 CDS rpsJ NC_011745.1 3894346 3894657 R NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 complement(3894346..3894657) Escherichia coli ED1a 7141454 YP_002399820.1 CDS pioO NC_011745.1 3894895 3895314 R calcium-binding protein that may be required for the initiation of chromosome replication; chromosome replication protein PioO complement(3894895..3895314) Escherichia coli ED1a 7140093 YP_002399821.1 CDS gspC NC_011745.1 3896965 3897780 D Evidence 2b : Function of strongly homologous gene; PubMedId : 96256608; Product type t : transporter; general secretory pathway component, cryptic 3896965..3897780 Escherichia coli ED1a 7143031 YP_002399822.1 CDS gspD NC_011745.1 3897764 3899716 D Evidence 2b : Function of strongly homologous gene; PubMedId : 96256608; Product type t : transporter; general secretory pathway component, cryptic 3897764..3899716 Escherichia coli ED1a 7143032 YP_002399823.1 CDS gspE NC_011745.1 3899726 3901207 D Evidence 2b : Function of strongly homologous gene; PubMedId : 96256608; Product type t : transporter; general secretory pathway component, cryptic 3899726..3901207 Escherichia coli ED1a 7143033 YP_002399824.1 CDS gspF NC_011745.1 3901204 3902400 D Evidence 2b : Function of strongly homologous gene; PubMedId : 96256608, 7896718; Product type t : transporter; general secretory pathway component, cryptic 3901204..3902400 Escherichia coli ED1a 7143034 YP_002399825.1 CDS gspG NC_011745.1 3902410 3902847 D Evidence 2b : Function of strongly homologous gene; PubMedId : 95204361, 96256608; Product type t : transporter; pseudopilin, cryptic, general secretion pathway 3902410..3902847 Escherichia coli ED1a 7143035 YP_002399826.1 CDS gspH NC_011745.1 3902855 3903364 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96256608; Product type pt : putative transporter; putative general secretory pathway component, cryptic 3902855..3903364 Escherichia coli ED1a 7143036 YP_002399827.1 CDS gspI NC_011745.1 3903361 3903738 D Evidence 2b : Function of strongly homologous gene; PubMedId : 96256608, 1588814; Product type t : transporter; general secretory pathway component, cryptic 3903361..3903738 Escherichia coli ED1a 7139755 YP_002399828.1 CDS gspJ NC_011745.1 3903731 3904318 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96256608; Product type pt : putative transporter; putative general secretory pathway component, cryptic 3903731..3904318 Escherichia coli ED1a 7139839 YP_002399829.1 CDS ECED1_3997 NC_011745.1 3904356 3904559 R Evidence 6 : Doubtful CDS; hypothetical protein complement(3904356..3904559) Escherichia coli ED1a 7139840 YP_002399830.1 CDS chiA NC_011745.1 3904749 3907274 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10760150, 10419961, 2661540; Product type e : enzyme; periplasmic endochitinase complement(3904749..3907274) Escherichia coli ED1a 7142303 YP_002399831.1 CDS tufA NC_011745.1 3907566 3908750 R EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu complement(3907566..3908750) Escherichia coli ED1a 7139344 YP_002399832.1 CDS fusA NC_011745.1 3908821 3910935 R EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G complement(3908821..3910935) Escherichia coli ED1a 7140842 YP_002399833.1 CDS rpsG NC_011745.1 3911032 3911502 R binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 complement(3911032..3911502) Escherichia coli ED1a 7143135 YP_002399834.1 CDS rpsL NC_011745.1 3911599 3911973 R interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 complement(3911599..3911973) Escherichia coli ED1a 7140090 YP_002399835.1 CDS tusB NC_011745.1 3912099 3912386 R in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusB complement(3912099..3912386) Escherichia coli ED1a 7140095 YP_002399836.1 CDS tusC NC_011745.1 3912393 3912752 R in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur relay protein TusC complement(3912393..3912752) Escherichia coli ED1a 7140846 YP_002399837.1 CDS tusD NC_011745.1 3912752 3913138 R in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusD complement(3912752..3913138) Escherichia coli ED1a 7140847 YP_002399838.1 CDS yheO NC_011745.1 3913138 3913860 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(3913138..3913860) Escherichia coli ED1a 7140848 YP_002399839.1 CDS fkpA NC_011745.1 3914027 3914839 R rotamase; FKBP-type peptidyl-prolyl cis-trans isomerase complement(3914027..3914839) Escherichia coli ED1a 7139504 YP_002399840.1 CDS slyX NC_011745.1 3915060 3915278 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3915060..3915278 Escherichia coli ED1a 7144194 YP_002399841.1 CDS slyD NC_011745.1 3915327 3915917 R rotamase; FKBP-type peptidyl-prolyl cis-trans isomerase complement(3915327..3915917) Escherichia coli ED1a 7143808 YP_002399842.1 CDS yheV NC_011745.1 3916012 3916212 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3916012..3916212) Escherichia coli ED1a 7143807 YP_002399843.1 CDS kefB NC_011745.1 3916222 3918027 R involved in potassium efflux; glutathione-regulated potassium-efflux system protein KefB complement(3916222..3918027) Escherichia coli ED1a 7139508 YP_002399844.1 CDS kefG NC_011745.1 3918027 3918581 R required for KefB activity; glutathione-regulated potassium-efflux system ancillary protein KefG complement(3918027..3918581) Escherichia coli ED1a 7142506 YP_002399845.1 CDS yheS NC_011745.1 3918709 3920622 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATP-binding protein 3918709..3920622 Escherichia coli ED1a 7142509 YP_002399846.1 CDS yheT NC_011745.1 3920622 3921644 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9889164; Product type pe : putative enzyme; putative hydrolase 3920622..3921644 Escherichia coli ED1a 7139505 YP_002399847.1 CDS yheU NC_011745.1 3921638 3921856 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3921638..3921856 Escherichia coli ED1a 7139506 YP_002399848.1 CDS prkB NC_011745.1 3921910 3922779 D Evidence 2b : Function of strongly homologous gene; PubMedId : 2559876; Product type e : enzyme; phosphoribulokinase 3921910..3922779 Escherichia coli ED1a 7139507 YP_002399849.1 CDS yhfA NC_011745.1 3922834 3923238 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3922834..3923238) Escherichia coli ED1a 7139122 YP_002399850.1 CDS ECED1_4020 NC_011745.1 3923318 3923533 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3923318..3923533 Escherichia coli ED1a 7142057 YP_002399851.1 CDS crp NC_011745.1 3923540 3924172 D complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons; cAMP-regulatory protein 3923540..3924172 Escherichia coli ED1a 7142304 YP_002399852.1 CDS yhfK NC_011745.1 3924211 3926313 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3924211..3926313 Escherichia coli ED1a 7142056 YP_002399853.1 CDS argD NC_011745.1 3926380 3927600 R DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate; bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein complement(3926380..3927600) Escherichia coli ED1a 7139511 YP_002399854.1 CDS pabA NC_011745.1 3927686 3928249 R aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; para-aminobenzoate synthase component II complement(3927686..3928249) Escherichia coli ED1a 7142612 YP_002399855.1 CDS fic NC_011745.1 3928281 3928883 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92021789, 94095125, 2007139, 2403545, 2546924, 7549107; Product type cp : cell process; cell filamentation protein Fic complement(3928281..3928883) Escherichia coli ED1a 7139998 YP_002399856.1 CDS yhfG NC_011745.1 3928873 3929040 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3928873..3929040) Escherichia coli ED1a 7144177 YP_002399857.1 CDS ppiA NC_011745.1 3929145 3929717 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90272647, 91175755, 1606970, 2001362, 2007139, 2190212, 2403545, 2546924, 8130188, 8180197; Product type e : enzyme; peptidyl-prolyl cis-trans isomerase A complement(3929145..3929717) Escherichia coli ED1a 7139510 YP_002399858.1 CDS tsgA NC_011745.1 3929988 3931169 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20509826; Product type pt : putative transporter; hypothetical protein 3929988..3931169 Escherichia coli ED1a 7139103 YP_002399859.1 CDS nirB NC_011745.1 3931431 3933974 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93062014, 2200672, 2445993, 2543955; Product type e : enzyme; nitrite reductase, large subunit, NAD(P) H-binding 3931431..3933974 Escherichia coli ED1a 7140835 YP_002399860.1 CDS nirD NC_011745.1 3933971 3934297 D involved in reducing nitrite to ammonium to detoxify nitrite accumulation in anaerobic nitrate-respiring cells and regenerate NAD+; bounds to NirB, the cytoplasmic subunit, whose expression is induced at high nitrate concentrations; nitrite reductase small subunit 3933971..3934297 Escherichia coli ED1a 7140394 YP_002399861.1 CDS nirC NC_011745.1 3934423 3935229 D member of the FNT family of formate and nitrite transporters; nitrite transporter NirC 3934423..3935229 Escherichia coli ED1a 7140396 YP_002399862.1 CDS cysG NC_011745.1 3935248 3936621 D multifunction enzyme consisting of uroporphyrin-III C-methyltransferase, precorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase; catalyzes the methylation of uroporphyrinogen III to form precorrin-2, then catalyzes formation of sirohydrochlorin from precorrin-2 and finally catalyzed the formation of siroheme from sirohydrochlorin; siroheme synthase 3935248..3936621 Escherichia coli ED1a 7140395 YP_002399863.1 CDS yhfL NC_011745.1 3936873 3937040 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3936873..3937040 Escherichia coli ED1a 7139221 YP_002399864.1 CDS yhfS NC_011745.1 3937148 3938233 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3937148..3938233) Escherichia coli ED1a 7139512 YP_002399865.1 CDS yhfT NC_011745.1 3938245 3939549 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(3938245..3939549) Escherichia coli ED1a 7139513 YP_002399866.1 CDS yhfU NC_011745.1 3939561 3939914 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3939561..3939914) Escherichia coli ED1a 7139514 YP_002399867.1 CDS php NC_011745.1 3939925 3940803 R phosphotriesterase homology protein; PhP; YhfV; member of a family of proteins related to phosphotriesterase (PTE); putative hydrolase complement(3939925..3940803) Escherichia coli ED1a 7139515 YP_002399868.1 CDS yhfW NC_011745.1 3940800 3942026 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative mutase complement(3940800..3942026) Escherichia coli ED1a 7144110 YP_002399869.1 CDS yhfX NC_011745.1 3942027 3943190 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative amino acid racemase complement(3942027..3943190) Escherichia coli ED1a 7139516 YP_002399870.1 CDS yhfY NC_011745.1 3943274 3943636 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3943274..3943636) Escherichia coli ED1a 7139517 YP_002399871.1 CDS yhfZ NC_011745.1 3943653 3944558 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3943653..3944558) Escherichia coli ED1a 7139518 YP_002399872.1 CDS trpS NC_011745.1 3944718 3945722 R catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase complement(3944718..3945722) Escherichia coli ED1a 7139519 YP_002399873.1 CDS gph NC_011745.1 3945715 3946473 R catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate; phosphoglycolate phosphatase complement(3945715..3946473) Escherichia coli ED1a 7140826 YP_002399874.1 CDS rpe NC_011745.1 3946466 3947143 R catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase complement(3946466..3947143) Escherichia coli ED1a 7143011 YP_002399875.1 CDS dam NC_011745.1 3947161 3947997 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90136529, 92262475, 92272672, 2549371, 6300769, 7603433, 8341592; Product type e : enzyme; DNA adenine methylase complement(3947161..3947997) Escherichia coli ED1a 7141447 YP_002399876.1 CDS damX NC_011745.1 3948104 3949390 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3948104..3949390) Escherichia coli ED1a 7143060 YP_002399877.1 CDS aroB NC_011745.1 3949482 3950570 R catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase complement(3949482..3950570) Escherichia coli ED1a 7143061 YP_002399878.1 CDS aroK NC_011745.1 3950627 3951148 R type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase I complement(3950627..3951148) Escherichia coli ED1a 7142624 YP_002399879.1 CDS hofQ NC_011745.1 3951549 3952787 R outer membrane porin probably involved in uptake of extracellular double-stranded DNA; similar to outer membrane competence protein ComE from Haemophilus influenzae and outer membrane protein PilQ involved in type IV pilus production from Pseudomonas aeruginosa; outer membrane porin HofQ complement(3951549..3952787) Escherichia coli ED1a 7142631 YP_002399880.1 CDS yrfA NC_011745.1 3952699 3953103 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3952699..3953103) Escherichia coli ED1a 7139908 YP_002399881.1 CDS yrfB NC_011745.1 3953093 3953533 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(3953093..3953533) Escherichia coli ED1a 7143246 YP_002399882.1 CDS yrfC NC_011745.1 3953517 3954056 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial assembly protein (pilN-like) complement(3953517..3954056) Escherichia coli ED1a 7143247 YP_002399883.1 CDS yrfD NC_011745.1 3954056 3954835 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative pilus assembly protein complement(3954056..3954835) Escherichia coli ED1a 7143248 YP_002399884.1 CDS mrcA NC_011745.1 3954955 3957507 D bifunctional murein transglycosylase/murein transpeptidase; penicillin-binding protein 1A; involved in the synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation; penicillin-insensitive transglycosylase catalyzes the formation of linear glycan strands and the penicillin-sensitive transpeptidase catalyzes the cross-linking of the peptide subunits; peptidoglycan synthetase 3954955..3957507 Escherichia coli ED1a 7143249 YP_002399885.1 CDS nudE NC_011745.1 3957674 3958234 R ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose diphosphatase NudE complement(3957674..3958234) Escherichia coli ED1a 7139022 YP_002399886.1 CDS igaA NC_011745.1 3958554 3960689 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11553591; Product type r : regulator; intracellular growth attenuator protein 3958554..3960689 Escherichia coli ED1a 7139940 YP_002399887.1 CDS yrfG NC_011745.1 3960754 3961422 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase 3960754..3961422 Escherichia coli ED1a 7140231 YP_002399888.1 CDS hslR NC_011745.1 3961433 3961834 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9867837, 10675343, 10675344; Product type f : factor; ribosome-associated heat shock protein Hsp15 3961433..3961834 Escherichia coli ED1a 7143250 YP_002399889.1 CDS hslO NC_011745.1 3961859 3962737 D becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 3961859..3962737 Escherichia coli ED1a 7140168 YP_002399890.1 CDS yhgE NC_011745.1 3962800 3964524 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 20223645; Product type pm : putative membrane component; hypothetical protein complement(3962800..3964524) Escherichia coli ED1a 7140167 YP_002399891.1 CDS ECED1_4062 NC_011745.1 3964600 3964731 R Evidence 6 : Doubtful CDS; hypothetical protein complement(3964600..3964731) Escherichia coli ED1a 7139521 YP_002399892.1 CDS pck NC_011745.1 3964903 3966525 D PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase 3964903..3966525 Escherichia coli ED1a 7142305 YP_002399893.1 CDS envZ NC_011745.1 3966602 3967954 R membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR; osmolarity sensor protein complement(3966602..3967954) Escherichia coli ED1a 7144048 YP_002399894.1 CDS ompR NC_011745.1 3967951 3968670 R part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation; osmolarity response regulator complement(3967951..3968670) Escherichia coli ED1a 7139802 YP_002399895.1 CDS greB NC_011745.1 3968898 3969374 D necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreB 3968898..3969374 Escherichia coli ED1a 7139974 YP_002399896.1 CDS yhgF NC_011745.1 3969471 3971792 D Evidence 2b : Function of strongly homologous gene; PubMedId : 8755871; Product type f : factor; transcriptional accessory protein 3969471..3971792 Escherichia coli ED1a 7143020 YP_002399897.1 CDS feoA NC_011745.1 3972248 3972475 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94012482, 8407793; Product type t : transporter; ferrous iron transport protein A 3972248..3972475 Escherichia coli ED1a 7139522 YP_002399898.1 CDS feoB NC_011745.1 3972492 3974813 D cytoplasmic membrane ferrous uptake system permease; mutations disrupt the ability of Escherichia coli to take up ferrous iron; GTP-binding protein which requires GTP for efficient iron(II) uptake; ferrous iron transport protein B 3972492..3974813 Escherichia coli ED1a 7144154 YP_002399899.1 CDS yhgG NC_011745.1 3974824 3975060 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3974824..3975060 Escherichia coli ED1a 7144155 YP_002399900.1 CDS bioH NC_011745.1 3975915 3976685 R Shows carboxylesterase activity with a preference for short chain fatty acid esters; involved in pimeloyl-CoA synthesis; carboxylesterase BioH complement(3975915..3976685) Escherichia coli ED1a 7139520 YP_002399901.1 CDS gntX NC_011745.1 3976723 3977406 D involved in high-affinity gluconate transport; gluconate periplasmic binding protein 3976723..3977406 Escherichia coli ED1a 7140455 YP_002399902.1 CDS gntY NC_011745.1 3977465 3978040 D cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source; putative DNA uptake protein 3977465..3978040 Escherichia coli ED1a 7143005 YP_002399903.1 CDS gntT NC_011745.1 3978404 3979720 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 172599, 4574689, 4582156, 93139975, 97141270, 98019089, 2845225, 3040894, 7984428, 9045817; Product type t : transporter; gluconate transporter, high-affinity GNT I system 3978404..3979720 Escherichia coli ED1a 7143006 YP_002399904.1 CDS malQ NC_011745.1 3979786 3981870 R amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase complement(3979786..3981870) Escherichia coli ED1a 7143003 YP_002399905.1 CDS malP NC_011745.1 3981880 3984273 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89033892, 10220320, 10469642, 2845225, 3037809, 3155826, 6283313, 6339728, 6986282, 9009262; Product type e : enzyme; maltodextrin phosphorylase complement(3981880..3984273) Escherichia coli ED1a 7142201 YP_002399906.1 CDS malT NC_011745.1 3984896 3987601 D Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides; transcriptional regulator MalT 3984896..3987601 Escherichia coli ED1a 7142200 YP_002399907.1 CDS rtcA NC_011745.1 3987644 3988660 R catalyzes the conversion of terminal3'-phosphate of RNA to the 2',3'-cyclicphosphodiester; RNA 3'-terminal-phosphate cyclase complement(3987644..3988660) Escherichia coli ED1a 7142203 YP_002399908.1 CDS rtcB NC_011745.1 3988664 3989890 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9738023; hypothetical protein complement(3988664..3989890) Escherichia coli ED1a 7140130 YP_002399909.1 CDS rtcR NC_011745.1 3990079 3991677 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9738023, 3045764, 7920643, 7984428; Product type r : regulator; sigma 54-dependent transcriptional regulator of rtcBA expression 3990079..3991677 Escherichia coli ED1a 7140131 YP_002399910.1 CDS glpR NC_011745.1 3991659 3992417 R represses the glpD, glpFK, glpTQ, and glpACB operons involved in glycerol-3-phosphate metabolism; DNA-binding transcriptional repressor GlpR complement(3991659..3992417) Escherichia coli ED1a 7140132 YP_002399911.1 CDS glpG NC_011745.1 3992434 3993264 R protease responsible for the cleavage between Ser and Asp residues of proteins in regions of high local hydrophilicity; intramembrane serine protease GlpG complement(3992434..3993264) Escherichia coli ED1a 7142975 YP_002399912.1 CDS glpE NC_011745.1 3993309 3993635 R belongs to rhodanese family; thiosulfate thiotransferase; in Escherichia coli this enzyme catalyzes the formation of thiocyanate from thiosulfate and cyanide with low efficiency; contains an active site cysteine; thiosulfate sulfurtransferase complement(3993309..3993635) Escherichia coli ED1a 7142972 YP_002399913.1 CDS glpD NC_011745.1 3993825 3995330 D in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane; glycerol-3-phosphate dehydrogenase 3993825..3995330 Escherichia coli ED1a 7142970 YP_002399914.1 CDS ECED1_4087 NC_011745.1 3995384 3995989 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3995384..3995989) Escherichia coli ED1a 7142969 YP_002399915.1 CDS ECED1_4088 NC_011745.1 3995992 3996759 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3995992..3996759) Escherichia coli ED1a 7142306 YP_002399916.1 CDS ECED1_4089 NC_011745.1 3996762 3997472 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3996762..3997472) Escherichia coli ED1a 7142307 YP_002399917.1 CDS aufG NC_011745.1 3997646 3998776 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15213132; Product type ps : putative structure; putative fimbrial-like adhesin protein AufG complement(3997646..3998776) Escherichia coli ED1a 7142308 YP_002399918.1 CDS insB NC_011745.1 3998848 3999351 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF2, IS1 complement(3998848..3999351) Escherichia coli ED1a 7140423 YP_002399919.1 CDS insA NC_011745.1 3999270 3999545 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF 1, IS1 complement(3999270..3999545) Escherichia coli ED1a 7141152 YP_002399920.1 CDS aufF NC_011745.1 3999574 4000368 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15213132; Product type pf : putative factor; putative fimbrial chaperone AufF complement(3999574..4000368) Escherichia coli ED1a 7141129 YP_002399921.1 CDS aufE NC_011745.1 4000313 4000891 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15213132; Product type ps : putative structure; putative minor fimbrial subunit AufE complement(4000313..4000891) Escherichia coli ED1a 7140422 YP_002399922.1 CDS aufD NC_011745.1 4000836 4001432 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative minor fimbrial subunit AufD complement(4000836..4001432) Escherichia coli ED1a 7140421 YP_002399923.1 CDS insA NC_011745.1 4001474 4001749 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF 1, IS1 4001474..4001749 Escherichia coli ED1a 7140420 YP_002399924.1 CDS insB NC_011745.1 4001668 4002171 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF2, IS1 4001668..4002171 Escherichia coli ED1a 7141130 YP_002399925.1 CDS aufC NC_011745.1 4002182 4004308 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15213132; Product type pf : putative factor; putative outer membrane export usher protein AufC complement(4002182..4004308) Escherichia coli ED1a 7141153 YP_002399926.1 CDS aufB NC_011745.1 4004345 4005124 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15213132; Product type pf : putative factor; putative fimbrial chaperone AufB complement(4004345..4005124) Escherichia coli ED1a 7140419 YP_002399927.1 CDS ECED1_4101 NC_011745.1 4006136 4006411 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF 1, IS1 4006136..4006411 Escherichia coli ED1a 7140417 YP_002399928.1 CDS insB NC_011745.1 4006330 4006833 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF2, IS1 4006330..4006833 Escherichia coli ED1a 7142309 YP_002399929.1 CDS glgP NC_011745.1 4007172 4009619 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88330897, 91104907, 91236706, 2645169, 2975249, 3047129, 3097003; Product type e : enzyme; glycogen phosphorylase complement(4007172..4009619) Escherichia coli ED1a 7141154 YP_002399930.1 CDS glgA NC_011745.1 4009638 4011071 R catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase complement(4009638..4011071) Escherichia coli ED1a 7143188 YP_002399931.1 CDS glgC NC_011745.1 4011071 4012366 R catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase complement(4011071..4012366) Escherichia coli ED1a 7143185 YP_002399932.1 CDS glgX NC_011745.1 4012384 4014357 R catalyzes the hydrolysis of the alpha-1,6-glucosidic linkages in partially depolymerized glycogen; glycogen debranching enzyme complement(4012384..4014357) Escherichia coli ED1a 7143187 YP_002399933.1 CDS glgB NC_011745.1 4014354 4016540 R catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching enzyme complement(4014354..4016540) Escherichia coli ED1a 7143190 YP_002399934.1 CDS asd NC_011745.1 4016813 4017916 R catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase complement(4016813..4017916) Escherichia coli ED1a 7143186 YP_002399935.1 CDS yhgN NC_011745.1 4018108 4018701 D YhgN; Ec0197; hydrolyzes nucleoside triphosphates with an O6 atom-containing purine base to nucleoside monophosphate and pyrophosphate; seems to play a role in the elimination of aberrant purine-derived nucleotides containing the 6-keto group; shows preference for deoxyinosine triphosphate and xanthosine triphosphate over standard nucleoside triphosphates (dATP, dCTP, dGTP, and dTTP); putative dITP- and XTP- hydrolase 4018108..4018701 Escherichia coli ED1a 7142641 YP_002399936.1 CDS gntU NC_011745.1 4018758 4020098 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8655507, 9119199, 9135111, 97141270; Product type t : transporter; low affinity gluconate transporter complement(4018758..4020098) Escherichia coli ED1a 7139524 YP_002399937.1 CDS gntK NC_011745.1 4020102 4020629 R thermoresistant; catalyzes the formation of 6-phospho-D-gluconate from gluconate; gluconate kinase 1 complement(4020102..4020629) Escherichia coli ED1a 7143004 YP_002399938.1 CDS gntR NC_011745.1 4020768 4021763 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 172599, 9135111, 93139975, 9537375, 8655507; Product type r : regulator; DNA-binding transcriptional repressor complement(4020768..4021763) Escherichia coli ED1a 7143000 YP_002399939.1 CDS yhhW NC_011745.1 4021856 4022551 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4021856..4022551) Escherichia coli ED1a 7143002 YP_002399940.1 CDS yhhX NC_011745.1 4022674 4023711 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10493123; Product type pe : putative enzyme; putative dehydrogenase complement(4022674..4023711) Escherichia coli ED1a 7139535 YP_002399941.1 CDS yhhY NC_011745.1 4024046 4024534 D YhhY; regulated by the fur regulator; unknown function; putative acetyltransferase YhhY 4024046..4024534 Escherichia coli ED1a 7141352 YP_002399942.1 CDS yrhA NC_011745.1 4025946 4026440 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4025946..4026440 Escherichia coli ED1a 7139539 YP_002399943.1 CDS yrhB NC_011745.1 4026890 4027174 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4026890..4027174 Escherichia coli ED1a 7143251 YP_002399944.1 CDS ggt NC_011745.1 4027212 4028972 R periplasmic enzyme; post-translationally processed into two subunits which are required for wild-type enzyme activity; cleaves the gammaglutamyl linkages of compounds such as glutathione and transfer the gammaglutamyl group to other amino acids and peptides; gamma-glutamyltranspeptidase complement(4027212..4028972) Escherichia coli ED1a 7143252 YP_002399945.1 CDS yhhA NC_011745.1 4029065 4029505 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4029065..4029505 Escherichia coli ED1a 7143175 YP_002399946.1 CDS ugpQ NC_011745.1 4029492 4030235 R hydrolyzes diesters during transport at the inner face of the cytoplasmic membrane to glycerol-3-phosphate and alcohol; induced when cells are starved for inorganic phosphate; cytoplasmic glycerophosphodiester phosphodiesterase complement(4029492..4030235) Escherichia coli ED1a 7139525 YP_002399947.1 CDS ugpC NC_011745.1 4030232 4031302 R part of the UgpABCE glycerol-3-phosphate uptake system; glycerol-3-phosphate transporter ATP-binding subunit complement(4030232..4031302) Escherichia coli ED1a 7138877 YP_002399948.1 CDS ugpE NC_011745.1 4031304 4032149 R with UgpABC is involved in uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter membrane protein complement(4031304..4032149) Escherichia coli ED1a 7138874 YP_002399949.1 CDS ugpA NC_011745.1 4032146 4033033 R with UgpEC is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter permease complement(4032146..4033033) Escherichia coli ED1a 7138876 YP_002399950.1 CDS ugpB NC_011745.1 4033131 4034447 R with UgpACE is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter periplasmic binding protein complement(4033131..4034447) Escherichia coli ED1a 7140869 YP_002399951.1 CDS livF NC_011745.1 4034844 4035557 R with LivGHMJ and LivGHMK is part of the high-affinity branched-chain amino acid transport system; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding subunit complement(4034844..4035557) Escherichia coli ED1a 7140870 YP_002399952.1 CDS livG NC_011745.1 4035559 4036326 R Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding subunit complement(4035559..4036326) Escherichia coli ED1a 7141890 YP_002399953.1 CDS livM NC_011745.1 4036323 4037600 R Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter permease subunit complement(4036323..4037600) Escherichia coli ED1a 7141891 YP_002399954.1 CDS livH NC_011745.1 4037597 4038523 R LivHMGF is the membrane component of the LIV-I/LS branched-chain amino acid transporter; branched-chain amino acid transporter permease subunit LivH complement(4037597..4038523) Escherichia coli ED1a 7141895 YP_002399955.1 CDS livK NC_011745.1 4038571 4039680 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14702302, 90307651, 2195019, 2649683, 3891753, 4077929, 9298646, 9298646; Product type t : transporter; leucine ABC transporter subunit periplasmic-binding protein complement(4038571..4039680) Escherichia coli ED1a 7141892 YP_002399956.1 CDS yhhK NC_011745.1 4040104 4040487 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4040104..4040487 Escherichia coli ED1a 7141894 YP_002399957.1 CDS livJ NC_011745.1 4040675 4041778 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14702302, 90307651, 2195019, 2649682, 328304, 3891753, 4077929, 9298646, 10972807; Product type t : transporter; leucine/isoleucine/valine ABC transporter subunit periplasmic-binding protein complement(4040675..4041778) Escherichia coli ED1a 7139528 YP_002399958.1 CDS rpoH NC_011745.1 4042049 4042903 R binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 complement(4042049..4042903) Escherichia coli ED1a 7141893 YP_002399959.1 CDS ftsX NC_011745.1 4043148 4044206 R putative ABC transporter, membrane protein; cell division protein FtsX complement(4043148..4044206) Escherichia coli ED1a 7141489 YP_002399960.1 CDS ftsE NC_011745.1 4044199 4044867 R putative ATP-binding protein of an ATP-binding cassette transporter; when bound to FtsX, FtsEX localizes to the cell division site and plays a role in the assembly or stability of the septal ring under low-salt growth conditions; cell division protein FtsE complement(4044199..4044867) Escherichia coli ED1a 7143121 YP_002399961.1 CDS ftsY NC_011745.1 4044870 4046366 R signal recognition protein receptor; functions in the targeting and insertion of membrane proteins; cell division protein FtsY complement(4044870..4046366) Escherichia coli ED1a 7142190 YP_002399962.1 CDS rsmD NC_011745.1 4046516 4047112 D catalyzes the methylation of 16S rRNA at position G966; 16S rRNA m(2)G966-methyltransferase 4046516..4047112 Escherichia coli ED1a 7143122 YP_002399963.1 CDS yhhL NC_011745.1 4047102 4047371 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4047102..4047371 Escherichia coli ED1a 7139526 YP_002399964.1 CDS yhhM NC_011745.1 4047374 4047733 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4047374..4047733) Escherichia coli ED1a 7139529 YP_002399965.1 CDS yhhN NC_011745.1 4047874 4048500 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4047874..4048500 Escherichia coli ED1a 7139530 YP_002399966.1 CDS zntA NC_011745.1 4048574 4050772 D P-type ATPase involved in the export of lead, cadmium, zinc and mercury; zinc/cadmium/mercury/lead-transporting ATPase 4048574..4050772 Escherichia coli ED1a 7139531 YP_002399967.1 CDS tusA NC_011745.1 4051041 4051286 R TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein SirA complement(4051041..4051286) Escherichia coli ED1a 7143276 YP_002399968.1 CDS yhhQ NC_011745.1 4051507 4052172 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4051507..4052172 Escherichia coli ED1a 7140845 YP_002399969.1 CDS dcrB NC_011745.1 4052245 4052802 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12558182, 8752353; Product type t : transporter; hypothetical protein 4052245..4052802 Escherichia coli ED1a 7139532 YP_002399970.1 CDS yhhS NC_011745.1 4052806 4054023 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; major facilitator superfamily transporter complement(4052806..4054023) Escherichia coli ED1a 7143071 YP_002399971.1 CDS yhhT NC_011745.1 4054155 4055204 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4054155..4055204 Escherichia coli ED1a 7139533 YP_002399972.1 CDS acpT NC_011745.1 4055259 4055846 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20092861, 10625633, 8939709; Product type e : enzyme; holo-(acyl carrier protein) synthase 2 4055259..4055846 Escherichia coli ED1a 7139534 YP_002399973.1 CDS nikA NC_011745.1 4055957 4057531 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12960164, 7934931, 92077434, 7867647; Product type t : transporter; nickel ABC transporter subunit periplasmic-binding protein 4055957..4057531 Escherichia coli ED1a 7143648 YP_002399974.1 CDS nikB NC_011745.1 4057531 4058475 D with NikACDE is involved in nickel transport into the cell; nickel transporter permease NikB 4057531..4058475 Escherichia coli ED1a 7140386 YP_002399975.1 CDS nikC NC_011745.1 4058472 4059305 D with NikABDE is involved in nickel transport into the cell; nickel transporter permease NikC 4058472..4059305 Escherichia coli ED1a 7140387 YP_002399976.1 CDS nikD NC_011745.1 4059305 4060069 D with NikABCE is involved in nickel transport into the cell; nickel transporter ATP-binding protein NikD 4059305..4060069 Escherichia coli ED1a 7140388 YP_002399977.1 CDS nikE NC_011745.1 4060066 4060872 D with NikABCD is involved with nickel transport into the cell; nickel transporter ATP-binding protein NikE 4060066..4060872 Escherichia coli ED1a 7140389 YP_002399978.1 CDS nikR NC_011745.1 4060878 4061279 D Inhibits transcription at high concentrations of nickel; nickel responsive regulator 4060878..4061279 Escherichia coli ED1a 7140390 YP_002399979.1 CDS yhhJ NC_011745.1 4061288 4062412 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter membrane protein complement(4061288..4062412) Escherichia coli ED1a 7140391 YP_002399980.1 CDS rbbA NC_011745.1 4062412 4065147 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20074572; Product type e : enzyme; fused ribosome-associated ATPase: ATP-binding protein ; ATP-binding protein ; putative membrane protein complement(4062412..4065147) Escherichia coli ED1a 7139527 YP_002399981.1 CDS yhiI NC_011745.1 4065144 4066211 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative HlyD family secretion protein complement(4065144..4066211) Escherichia coli ED1a 7141253 YP_002399982.1 CDS yhiM NC_011745.1 4066933 4067997 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4066933..4067997 Escherichia coli ED1a 7139542 YP_002399983.1 CDS yhiN NC_011745.1 4068084 4069277 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase with FAD/NAD(P)-binding domain complement(4068084..4069277) Escherichia coli ED1a 7139543 YP_002399984.1 CDS pitA NC_011745.1 4069509 4071008 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87014120; Product type t : transporter; phosphate transporter, low-affinity 4069509..4071008 Escherichia coli ED1a 7139544 YP_002399985.1 CDS yhiO NC_011745.1 4071079 4071414 R ppGpp-dependent, membrane associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress; universal stress protein UspB complement(4071079..4071414) Escherichia coli ED1a 7139065 YP_002399986.1 CDS uspA NC_011745.1 4071805 4072239 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12732303, 93086426, 93308072, 94203056, 10499297, 10652104, 10931298, 11157932, 1453957, 8506346, 8932299, 9298646, 9405142; Product type f : factor; universal stress global response regulator 4071805..4072239 Escherichia coli ED1a 7139545 YP_002399987.1 CDS yhiP NC_011745.1 4072556 4074025 D member of the POT family of peptide transporters; probable proton-dependent peptide transporter function; inner membrane transporter YhiP 4072556..4074025 Escherichia coli ED1a 7139145 YP_002399988.1 CDS yhiQ NC_011745.1 4074074 4074826 R predicted SAM-dependent methyltransferase; putative methyltransferase complement(4074074..4074826) Escherichia coli ED1a 7139546 YP_002399989.1 CDS prlC NC_011745.1 4074834 4076876 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92394891, 1325967, 8366062; Product type e : enzyme; oligopeptidase A complement(4074834..4076876) Escherichia coli ED1a 7139593 YP_002399990.1 CDS yhiR NC_011745.1 4077079 4077921 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11591672; Product type pe : putative enzyme; putative DNA (exogenous) processing protein 4077079..4077921 Escherichia coli ED1a 7139123 YP_002399991.1 CDS gor NC_011745.1 4077993 4079345 D catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 4077993..4079345 Escherichia coli ED1a 7139674 YP_002399992.1 CDS ECED1_4170 NC_011745.1 4079399 4079548 R Evidence 6 : Doubtful CDS; hypothetical protein complement(4079399..4079548) Escherichia coli ED1a 7143007 YP_002399993.1 CDS ECED1_4171 NC_011745.1 4079504 4079725 D Evidence 6 : Doubtful CDS; hypothetical protein 4079504..4079725 Escherichia coli ED1a 7142310 YP_002399994.1 CDS arsC NC_011745.1 4079817 4080242 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95355341, 7721697; Product type e : enzyme; arsenate reductase 4079817..4080242 Escherichia coli ED1a 7142311 YP_002399995.1 CDS slp NC_011745.1 4081429 4081995 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94293775, 8022277; Product type lp : lipoprotein; outer membrane lipoprotein 4081429..4081995 Escherichia coli ED1a 7139675 YP_002399996.1 CDS yhiF NC_011745.1 4082148 4082678 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8022277; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 4082148..4082678 Escherichia coli ED1a 7143803 YP_002399997.1 CDS chuS NC_011745.1 4082735 4083763 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16275907; Product type e : enzyme; Heme oxygenase complement(4082735..4083763) Escherichia coli ED1a 7139541 YP_002399998.1 CDS chuT NC_011745.1 4086400 4087392 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7768795, 9393841, 9680204; Product type pt : putative transporter; putative periplasmic binding protein 4086400..4087392 Escherichia coli ED1a 7139348 YP_002399999.1 CDS ECED1_4181 NC_011745.1 4087412 4088749 D catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 4087412..4088749 Escherichia coli ED1a 7139350 YP_002400000.1 CDS ECED1_4182 NC_011745.1 4088762 4089256 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4088762..4089256 Escherichia coli ED1a 7142312 YP_002400001.1 CDS ECED1_4183 NC_011745.1 4089256 4089879 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4089256..4089879 Escherichia coli ED1a 7142313 YP_002400002.1 CDS chuU NC_011745.1 4089928 4090920 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative hemin transport system permease 4089928..4090920 Escherichia coli ED1a 7142314 YP_002400003.1 CDS hmuV NC_011745.1 4090917 4091687 D with HmuTU is involved in the transport of hemin; hemin importer ATP-binding subunit 4090917..4091687 Escherichia coli ED1a 7139351 YP_002400004.1 CDS yhiD NC_011745.1 4091739 4092386 R inner membrane protein involved in cell density-dependent acid resistance; part of the acid fitness island (AFI) of E. coli; putative Mg(2+) transport ATPase complement(4091739..4092386) Escherichia coli ED1a 7139352 YP_002400005.1 CDS hdeB NC_011745.1 4092450 4092776 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94064579, 8885264, 12071744, 8244952, 8455549, 9298646, 9868784; Product type pf : putative factor; acid-resistance protein complement(4092450..4092776) Escherichia coli ED1a 7139540 YP_002400006.1 CDS hdeA NC_011745.1 4092892 4093224 R inactive form; acid-resistance protein complement(4092892..4093224) Escherichia coli ED1a 7139860 YP_002400007.1 CDS hdeD NC_011745.1 4093479 4094051 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94064579, 8244952, 8455549; Product type pm : putative membrane component; acid-resistance membrane protein 4093479..4094051 Escherichia coli ED1a 7139859 YP_002400008.1 CDS gadE NC_011745.1 4094850 4095377 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12399493, 12940989, 14702398; Product type r : regulator; DNA-binding transcriptional activator 4094850..4095377 Escherichia coli ED1a 7139861 YP_002400009.1 CDS mdtE NC_011745.1 4095716 4096873 D with MdtF and tolC is involved in resistance to rhodamine 6G, erythromycin, doxorubicin and other compounds; multidrug efflux system protein MdtE 4095716..4096873 Escherichia coli ED1a 7143144 YP_002400010.1 CDS mdtF NC_011745.1 4096898 4100011 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21450803; Product type t : transporter; multidrug transporter, RpoS-dependent 4096898..4100011 Escherichia coli ED1a 7142231 YP_002400011.1 CDS gadW NC_011745.1 4100374 4101102 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12446650; Product type r : regulator; DNA-binding transcriptional activator complement(4100374..4101102) Escherichia coli ED1a 7142232 YP_002400012.1 CDS gadX NC_011745.1 4101471 4102295 R regulates genes in response to acid and/or during stationary phase; DNA-binding transcriptional regulator GadX complement(4101471..4102295) Escherichia coli ED1a 7143147 YP_002400013.1 CDS gadA NC_011745.1 4102664 4104064 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92155241, 92394884, 99406302, 1522060, 1740158, 7764225, 9298646; Product type e : enzyme; glutamate decarboxylase A, PLP-dependent complement(4102664..4104064) Escherichia coli ED1a 7143146 YP_002400014.1 CDS yhjA NC_011745.1 4104275 4105672 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8163487, 14563563; Product type e : enzyme; cytochrome C peroxidase (cpp-like) complement(4104275..4105672) Escherichia coli ED1a 7143141 YP_002400015.1 CDS treF NC_011745.1 4106077 4107726 D cytoplasmic; catalyzes the hydrolysis of trehalose to glucose; trehalase 4106077..4107726 Escherichia coli ED1a 7139676 YP_002400016.1 CDS yhjB NC_011745.1 4107777 4108379 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding response regulator in two-component regulatory system complement(4107777..4108379) Escherichia coli ED1a 7140807 YP_002400017.1 CDS yhjC NC_011745.1 4108827 4109798 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 4108827..4109798 Escherichia coli ED1a 7139677 YP_002400018.1 CDS yhjD NC_011745.1 4109847 4110860 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4109847..4110860 Escherichia coli ED1a 7139678 YP_002400019.1 CDS yhjE NC_011745.1 4111253 4112575 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 4111253..4112575 Escherichia coli ED1a 7139679 YP_002400020.1 CDS yhjG NC_011745.1 4112616 4114691 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative outer membrane biogenesis protein complement(4112616..4114691) Escherichia coli ED1a 7139680 YP_002400021.1 CDS yhjH NC_011745.1 4114746 4115513 R in Escherichia coli this protein is involved in flagellar function; EAL domain-containing protein complement(4114746..4115513) Escherichia coli ED1a 7139681 YP_002400022.1 CDS kdgK NC_011745.1 4115745 4116674 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 4359651, 13813474; Product type e : enzyme; ketodeoxygluconokinase 4115745..4116674 Escherichia coli ED1a 7139682 YP_002400023.1 CDS yhjJ NC_011745.1 4116770 4118266 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9298646; Product type pe : putative enzyme; putative zinc-dependent peptidase complement(4116770..4118266) Escherichia coli ED1a 7142490 YP_002400024.1 CDS dctA NC_011745.1 4118486 4119772 R involved in the transport of C4-dicarboxylates across the membrane; C4-dicarboxylate transporter DctA complement(4118486..4119772) Escherichia coli ED1a 7139683 YP_002400025.1 CDS yhjK NC_011745.1 4119955 4121904 R HmsP in Yersinia pestis plays a role in invasion of epithelial cells; the EAL-domain portion of HmsP from Y. pestis shows phosphodiesterase activity which is required for the inhibition of biofilm formation; inner membrane protein; similar to a putative phosphodiesterase protein from E. coli; putative phosphodiesterase complement(4119955..4121904) Escherichia coli ED1a 7143072 YP_002400026.1 CDS bcsC NC_011745.1 4122026 4125499 R cellulose is produced by the multicellular morphotypes of E. coli and Salmonella typhimurium; the cellulose biosynthesis genes bcsA, bcsB, bcsZ and bcsC are constitutively transcribed, however, cellulose synthesis is dependent on the expression of adrA; cellulose synthase subunit BcsC complement(4122026..4125499) Escherichia coli ED1a 7139684 YP_002400027.1 CDS bcsZ NC_011745.1 4125481 4126587 R catalyzes the hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; endo-1,4-D-glucanase complement(4125481..4126587) Escherichia coli ED1a 7140437 YP_002400028.1 CDS bcsB NC_011745.1 4126594 4128933 R binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP); cellulose synthase regulator protein complement(4126594..4128933) Escherichia coli ED1a 7140441 YP_002400029.1 CDS bcsA NC_011745.1 4128944 4131562 R polymerizes uridine 5'-diphosphate glucose to cellulose; acts with BcsB, BcsZ and BcsC in cellulose biosynthesis; cellulose synthase catalytic subunit complement(4128944..4131562) Escherichia coli ED1a 7140436 YP_002400030.1 CDS yhjQ NC_011745.1 4131673 4132311 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9054507; Product type pe : putative enzyme; putative chromosome partitioning ATPase complement(4131673..4132311) Escherichia coli ED1a 7140435 YP_002400031.1 CDS yhjR NC_011745.1 4132323 4132511 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4132323..4132511) Escherichia coli ED1a 7139685 YP_002400032.1 CDS bcsE NC_011745.1 4132784 4134355 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11929533, 11260463; Product type pe : putative enzyme; putative cellulose biosynthesis protease 4132784..4134355 Escherichia coli ED1a 7139686 YP_002400033.1 CDS bcsF NC_011745.1 4134352 4134543 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4134352..4134543 Escherichia coli ED1a 7140438 YP_002400034.1 CDS bcsG NC_011745.1 4134540 4136219 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11929533, 11260463; Product type pe : putative enzyme; putative cellulose biosynthesis endoglucanase 4134540..4136219 Escherichia coli ED1a 7140439 YP_002400035.1 CDS ECED1_4217 NC_011745.1 4136578 4136739 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4136578..4136739) Escherichia coli ED1a 7141573 YP_002400036.1 CDS yhjV NC_011745.1 4136889 4138160 D Evidence 2b : Function of strongly homologous gene; PubMedId : 15901718; Product type t : transporter; transporter 4136889..4138160 Escherichia coli ED1a 7142315 YP_002400037.1 CDS dppF NC_011745.1 4138190 4139194 R Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides; dipeptide transporter ATP-binding subunit complement(4138190..4139194) Escherichia coli ED1a 7139687 YP_002400038.1 CDS dppD NC_011745.1 4139191 4140174 R DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF; dipeptide transporter ATP-binding subunit complement(4139191..4140174) Escherichia coli ED1a 7140518 YP_002400039.1 CDS dppC NC_011745.1 4140185 4141087 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7536291; Product type t : transporter; dipeptide transporter complement(4140185..4141087) Escherichia coli ED1a 7140517 YP_002400040.1 CDS dppB NC_011745.1 4141097 4142116 R transports peptides consisting of two or three amino acids; dipeptide transporter permease DppB complement(4141097..4142116) Escherichia coli ED1a 7140516 YP_002400041.1 CDS dppA NC_011745.1 4142423 4144030 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91100289, 92065799, 1702779, 1956284, 7536291, 8527431, 8563629, 9298646, 9600841, 9740056, 10972807; Product type t : transporter; dipeptide ABC transporter periplasmic-binding complement(4142423..4144030) Escherichia coli ED1a 7140515 YP_002400042.1 CDS eptB NC_011745.1 4144939 4146630 R catalyzes the addition of a phosphoethanolamine group to the outer Kdo residue of lipopolysaccharide; phosphoethanolamine transferase complement(4144939..4146630) Escherichia coli ED1a 7140606 YP_002400043.1 CDS lpfE NC_011745.1 4146883 4147407 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14977923; Product type pm : putative membrane component; LpfE protein complement(4146883..4147407) Escherichia coli ED1a 7139808 YP_002400044.1 CDS ECED1_4226 NC_011745.1 4147413 4148297 R Evidence 7 : Gene remnant; Product type s : structure; putative minor fimbrial subunit (fragment) complement(4147413..4148297) Escherichia coli ED1a 7141912 YP_002400045.1 CDS insB NC_011745.1 4148372 4148875 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF2, IS1 4148372..4148875 Escherichia coli ED1a 7142316 YP_002400046.1 CDS ECED1_4228 NC_011745.1 4148886 4149272 R Evidence 7 : Gene remnant; Product type s : structure; putative minor fimbrial subunit (fragment) complement(4148886..4149272) Escherichia coli ED1a 7141155 YP_002400047.1 CDS lpfC NC_011745.1 4149253 4151784 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14977923; Product type m : membrane component; outer membrane usher protein lpfC complement(4149253..4151784) Escherichia coli ED1a 7142317 YP_002400048.1 CDS lpfB NC_011745.1 4151807 4152493 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14977923; Product type m : membrane component; Chaperone protein lpfB complement(4151807..4152493) Escherichia coli ED1a 7141911 YP_002400049.1 CDS lpfA NC_011745.1 4152577 4153101 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14977923; Product type m : membrane component; Long polar fimbria protein A complement(4152577..4153101) Escherichia coli ED1a 7141910 YP_002400050.1 CDS yhjX NC_011745.1 4153425 4154672 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter complement(4153425..4154672) Escherichia coli ED1a 7141909 YP_002400051.1 CDS yhjY NC_011745.1 4154856 4155554 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4154856..4155554) Escherichia coli ED1a 7139688 YP_002400052.1 CDS tag NC_011745.1 4155712 4156275 D constitutive, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine; 3-methyl-adenine DNA glycosylase I 4155712..4156275 Escherichia coli ED1a 7139689 YP_002400053.1 CDS yiaC NC_011745.1 4156272 4156712 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11237876; Product type pe : putative enzyme; hypothetical protein 4156272..4156712 Escherichia coli ED1a 7141504 YP_002400054.1 CDS bisC NC_011745.1 4156681 4158960 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82119950, 90202748, 2180922, 374979; Product type e : enzyme; biotin sulfoxide reductase complement(4156681..4158960) Escherichia coli ED1a 7139693 YP_002400055.1 CDS yiaD NC_011745.1 4159167 4159826 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative outer membrane lipoprotein 4159167..4159826 Escherichia coli ED1a 7140458 YP_002400056.1 CDS tiaE NC_011745.1 4159930 4160904 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15801772, 11237876, 99030322, 99357626, 9298646, 9811658; Product type e : enzyme; 2-oxo-carboxylic acid reductase 4159930..4160904 Escherichia coli ED1a 7139694 YP_002400057.1 CDS yiaF NC_011745.1 4160954 4161664 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4160954..4161664) Escherichia coli ED1a 7141556 YP_002400058.1 CDS yiaG NC_011745.1 4162098 4162388 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 4162098..4162388 Escherichia coli ED1a 7139695 YP_002400059.1 CDS cspA NC_011745.1 4162669 4162881 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20345064, 90115858, 94293754, 94293756, 99177178, 10696873, 1597410, 1961761, 2404279, 7515185, 8197194, 9405743, 9439003, 9692981; Product type f : factor; major cold shock protein 4162669..4162881 Escherichia coli ED1a 7139696 YP_002400060.1 CDS glyS NC_011745.1 4163544 4165613 R glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta complement(4163544..4165613) Escherichia coli ED1a 7142069 YP_002400061.1 CDS glyQ NC_011745.1 4165623 4166534 R glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha complement(4165623..4166534) Escherichia coli ED1a 7142992 YP_002400062.1 CDS ysaB NC_011745.1 4166629 4166937 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4166629..4166937) Escherichia coli ED1a 7142991 YP_002400063.1 CDS yiaH NC_011745.1 4167112 4168107 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4167112..4168107 Escherichia coli ED1a 7143253 YP_002400064.1 CDS yiaB NC_011745.1 4168630 4168971 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6320721; Product type pm : putative membrane component; hypothetical protein complement(4168630..4168971) Escherichia coli ED1a 7139691 YP_002400065.1 CDS xylB NC_011745.1 4169140 4170594 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6330500, 92366447, 95050816, 6320721; Product type e : enzyme; xylulokinase complement(4169140..4170594) Escherichia coli ED1a 7139692 YP_002400066.1 CDS xylA NC_011745.1 4170666 4171988 R catalyzes the interconversion of D-xylose to D-xylulose; xylose isomerase complement(4170666..4171988) Escherichia coli ED1a 7139213 YP_002400067.1 CDS xylF NC_011745.1 4172354 4173346 D periplasmic substrate-binding component of the ATP-dependent xylose transport system; high affinity; D-xylose transporter subunit XylF 4172354..4173346 Escherichia coli ED1a 7139212 YP_002400068.1 CDS xylH NC_011745.1 4174943 4176124 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94316500; Product type t : transporter; D-xylose ABC transporter membrane protein 4174943..4176124 Escherichia coli ED1a 7139217 YP_002400069.1 CDS ECED1_4255 NC_011745.1 4176036 4176212 D Evidence 6 : Doubtful CDS; hypothetical protein 4176036..4176212 Escherichia coli ED1a 7139218 YP_002400070.1 CDS xylR NC_011745.1 4176202 4177380 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6330500, 94316500; Product type r : regulator; DNA-binding transcriptional activator, xylose-binding 4176202..4177380 Escherichia coli ED1a 7142318 YP_002400071.1 CDS bax NC_011745.1 4177488 4178312 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1544897; hypothetical protein complement(4177488..4178312) Escherichia coli ED1a 7139219 YP_002400072.1 CDS malS NC_011745.1 4178632 4180662 D periplasmic enzyme that degrades maltodextrins that enter via the outer membrane porin LamB; hydrolyzes alpha-(1,4) glycosidic linkages; contains internal disulfide bonds; periplasmic alpha-amylase 4178632..4180662 Escherichia coli ED1a 7140432 YP_002400073.1 CDS avtA NC_011745.1 4180840 4182093 D transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis; valine--pyruvate transaminase 4180840..4182093 Escherichia coli ED1a 7142202 YP_002400074.1 CDS yiaI NC_011745.1 4182245 4182718 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative hydrogenase, 4Fe-4S ferredoxin-type component complement(4182245..4182718) Escherichia coli ED1a 7140424 YP_002400075.1 CDS yiaJ NC_011745.1 4182820 4183668 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 20372646, 9826648; Product type r : regulator; DNA-binding transcriptional repressor complement(4182820..4183668) Escherichia coli ED1a 7139698 YP_002400076.1 CDS yiaK NC_011745.1 4183869 4184867 D NAD(P)H-dependent; catalyzes the reduction of 2,3-diketo-L-gulonate to 3-keto-L-gulonate; 2,3-diketo-L-gulonate reductase 4183869..4184867 Escherichia coli ED1a 7139699 YP_002400077.1 CDS yiaL NC_011745.1 4184879 4185343 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 21617392; hypothetical protein 4184879..4185343 Escherichia coli ED1a 7139700 YP_002400078.1 CDS ECED1_4265 NC_011745.1 4185366 4186286 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4185366..4186286 Escherichia coli ED1a 7139701 YP_002400079.1 CDS yiaM NC_011745.1 4186400 4186867 D membrane-spanning protein involved in uptake of 2,3-diketo-L-gulonate; part of the tri-partite ATP-independent periplasmic transport system (TRAP) YiaMNO; 2,3-diketo-L-gulonate TRAP transporter small permease YiaM 4186400..4186867 Escherichia coli ED1a 7142319 YP_002400080.1 CDS yiaN NC_011745.1 4186672 4188147 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14668138, 21617392; Product type t : transporter; transporter 4186672..4188147 Escherichia coli ED1a 7139702 YP_002400081.1 CDS yiaO NC_011745.1 4188160 4189146 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14668138, 21617392; Product type t : transporter; transporter 4188160..4189146 Escherichia coli ED1a 7139703 YP_002400082.1 CDS lyxK NC_011745.1 4189150 4190646 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21617392, 95050816, 7961955; Product type e : enzyme; L-xylulose kinase 4189150..4190646 Escherichia coli ED1a 7139704 YP_002400083.1 CDS sgbH NC_011745.1 4190643 4191305 D catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate; 3-keto-L-gulonate-6-phosphate decarboxylase 4190643..4191305 Escherichia coli ED1a 7141937 YP_002400084.1 CDS sgbU NC_011745.1 4191298 4192158 D L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate; putative L-xylulose 5-phosphate 3-epimerase 4191298..4192158 Escherichia coli ED1a 7140323 YP_002400085.1 CDS sgbE NC_011745.1 4192152 4192847 D catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 4192152..4192847 Escherichia coli ED1a 7141704 YP_002400086.1 CDS aldB NC_011745.1 4192894 4194432 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95286498, 7768815; Product type e : enzyme; aldehyde dehydrogenase B complement(4192894..4194432) Escherichia coli ED1a 7141406 YP_002400087.1 CDS ECED1_4274 NC_011745.1 4194540 4195835 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4194540..4195835) Escherichia coli ED1a 7143687 YP_002400088.1 CDS yiaY NC_011745.1 4195965 4197116 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2935393; Product type e : enzyme; putative alcohol dehydrogenase complement(4195965..4197116) Escherichia coli ED1a 7142320 YP_002400089.1 CDS selB NC_011745.1 4197307 4199151 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90264431, 91317715, 9315303, 94148228, 2140572, 2531290; Product type f : factor; selenocysteinyl-tRNA-specific translation factor complement(4197307..4199151) Escherichia coli ED1a 7139705 YP_002400090.1 CDS selA NC_011745.1 4199148 4200539 R catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis; selenocysteine synthase complement(4199148..4200539) Escherichia coli ED1a 7141394 YP_002400091.1 CDS yibF NC_011745.1 4200637 4201245 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8387990; Product type pe : putative enzyme; putative glutathione S-transferase complement(4200637..4201245) Escherichia coli ED1a 7141393 YP_002400092.1 CDS yibH NC_011745.1 4201316 4202452 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4201316..4202452) Escherichia coli ED1a 7139707 YP_002400093.1 CDS yibI NC_011745.1 4202455 4202817 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(4202455..4202817) Escherichia coli ED1a 7139708 YP_002400094.1 CDS mtlA NC_011745.1 4203354 4205267 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92052139, 92283796, 94131964, 1946374, 3135464, 3142516, 6309813, 9551558; Product type t : transporter; fused mannitol-specific PTS enzymes: IIA components ; IIB components ; IIC components 4203354..4205267 Escherichia coli ED1a 7139709 YP_002400095.1 CDS mtlD NC_011745.1 4205586 4206734 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90254197, 1964486, 3135464, 6384188, 8300537, 13295236; Product type e : enzyme; mannitol-1-phosphate 5-dehydrogenase 4205586..4206734 Escherichia coli ED1a 7139038 YP_002400096.1 CDS mtlR NC_011745.1 4206734 4207321 D Acts as a repressor of the mtlAD operon; mannitol repressor protein 4206734..4207321 Escherichia coli ED1a 7139039 YP_002400097.1 CDS yibT NC_011745.1 4207332 4207541 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4207332..4207541) Escherichia coli ED1a 7139040 YP_002400098.1 CDS yibL NC_011745.1 4207825 4208187 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4207825..4208187 Escherichia coli ED1a 7139714 YP_002400099.1 CDS ECED1_4286 NC_011745.1 4208443 4208679 R Evidence 6 : Doubtful CDS; hypothetical protein complement(4208443..4208679) Escherichia coli ED1a 7139711 YP_002400100.1 CDS ECED1_4287 NC_011745.1 4208745 4209428 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4208745..4209428 Escherichia coli ED1a 7142321 YP_002400101.1 CDS ECED1_4288 NC_011745.1 4209472 4214274 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative hemagglutinin adhesin 4209472..4214274 Escherichia coli ED1a 7142322 YP_002400102.1 CDS lldP NC_011745.1 4214686 4216341 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94012541, 11283302, 11785976, 8407843; Product type t : transporter; L-lactate permease 4214686..4216341 Escherichia coli ED1a 7142323 YP_002400103.1 CDS lldR NC_011745.1 4216341 4217117 D represses the lctPRD operon; DNA-binding transcriptional repressor LldR 4216341..4217117 Escherichia coli ED1a 7141897 YP_002400104.1 CDS lldD NC_011745.1 4217114 4218304 D flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration; L-lactate dehydrogenase 4217114..4218304 Escherichia coli ED1a 7141898 YP_002400105.1 CDS yibK NC_011745.1 4218352 4218825 D member of the SPOUT superfamily of RNA methyltransferases; no methyltransferase activity observed with certain tRNA substrates; putative tRNA/rRNA methyltransferase YibK 4218352..4218825 Escherichia coli ED1a 7141896 YP_002400106.1 CDS cysE NC_011745.1 4218880 4219701 R catalyzes the O-acetylation of serine; serine acetyltransferase complement(4218880..4219701) Escherichia coli ED1a 7139710 YP_002400107.1 CDS gpsA NC_011745.1 4219781 4220800 R catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase complement(4219781..4220800) Escherichia coli ED1a 7142111 YP_002400108.1 CDS secB NC_011745.1 4220800 4221267 R molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB complement(4220800..4221267) Escherichia coli ED1a 7143015 YP_002400109.1 CDS grxC NC_011745.1 4221331 4221582 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94316500, 95024051, 99175138, 11031118, 7937896, 8636094, 9973569; Product type c : carrier; glutaredoxin 3 complement(4221331..4221582) Escherichia coli ED1a 7141386 YP_002400110.1 CDS yibN NC_011745.1 4221723 4222154 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative rhodanese-related sulfurtransferase complement(4221723..4222154) Escherichia coli ED1a 7143026 YP_002400111.1 CDS gpmI NC_011745.1 4222399 4223943 D catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate; phosphoglyceromutase 4222399..4223943 Escherichia coli ED1a 7139712 YP_002400112.1 CDS envC NC_011745.1 4223977 4225236 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12113939, 21972773; Product type cp : cell process; hypothetical protein 4223977..4225236 Escherichia coli ED1a 7143013 YP_002400113.1 CDS yibQ NC_011745.1 4225240 4226199 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative polysaccharide deacetylase 4225240..4226199 Escherichia coli ED1a 7139800 YP_002400114.1 CDS yibD NC_011745.1 4226186 4227220 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15659689, 2647748; Product type pe : putative enzyme; putative glycosyl transferase complement(4226186..4227220) Escherichia coli ED1a 7139713 YP_002400115.1 CDS tdh NC_011745.1 4227459 4228484 R converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism; L-threonine 3-dehydrogenase complement(4227459..4228484) Escherichia coli ED1a 7139706 YP_002400116.1 CDS kbl NC_011745.1 4228494 4229690 R catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine; 2-amino-3-ketobutyrate coenzyme A ligase complement(4228494..4229690) Escherichia coli ED1a 7141530 YP_002400117.1 CDS htrL NC_011745.1 4229965 4230822 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4229965..4230822) Escherichia coli ED1a 7142488 YP_002400118.1 CDS rfaD NC_011745.1 4231126 4232058 D catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose; ADP-L-glycero-D-mannoheptose-6-epimerase 4231126..4232058 Escherichia coli ED1a 7140177 YP_002400119.1 CDS waaF NC_011745.1 4232068 4233114 D catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core; ADP-heptose:LPS heptosyltransferase II 4232068..4233114 Escherichia coli ED1a 7139172 YP_002400120.1 CDS waaC NC_011745.1 4233118 4234110 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20507564, 92250420, 93239678, 9446588, 1624462, 8478319; Product type e : enzyme; ADP-heptose:LPS heptosyl transferase I 4233118..4234110 Escherichia coli ED1a 7139173 YP_002400121.1 CDS rfaL NC_011745.1 4234107 4235315 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1657881; Product type e : enzyme; O-antigen ligase 4234107..4235315 Escherichia coli ED1a 7139171 YP_002400122.1 CDS rfaK NC_011745.1 4235350 4236492 R Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; lipopolysaccharide 1, 2-N-acetylglucosaminetransferase complement(4235350..4236492) Escherichia coli ED1a 7141596 YP_002400123.1 CDS rfaJ NC_011745.1 4236501 4237514 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92210496, 92250420, 92325066, 99251135, 1624461; Product type e : enzyme; lipopolysaccharide 1,2-glucosyltransferase complement(4236501..4237514) Escherichia coli ED1a 7141595 YP_002400124.1 CDS rfaY NC_011745.1 4237539 4238246 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1624462, 8041620, 9278503, 92250420, 92325067, 9756860; Product type e : enzyme; lipopolysaccharide core biosynthesis protein complement(4237539..4238246) Escherichia coli ED1a 7141594 YP_002400125.1 CDS rfaI NC_011745.1 4238272 4239279 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92210496, 92250420, 92325066, 9765561, 1624461; Product type e : enzyme; lipopolysaccharide 1,3-galactosyltransferase complement(4238272..4239279) Escherichia coli ED1a 7141597 YP_002400126.1 CDS waaP NC_011745.1 4239322 4240128 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21101922, 92121133, 92210496, 9756860, 1732225; Product type e : enzyme; kinase that phosphorylates core heptose of lipopolysaccharide complement(4239322..4240128) Escherichia coli ED1a 7141593 YP_002400127.1 CDS waaG NC_011745.1 4240112 4241236 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92121133, 92210496, 92250420, 1447141, 1732225, 7988890; Product type e : enzyme; glucosyltransferase I complement(4240112..4241236) Escherichia coli ED1a 7139175 YP_002400128.1 CDS waaQ NC_011745.1 4241233 4242291 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9756860, 1447141, 1732225; Product type e : enzyme; lipopolysaccharide core biosynthesis protein complement(4241233..4242291) Escherichia coli ED1a 7139174 YP_002400129.1 CDS kdtA NC_011745.1 4242704 4243981 D catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A; 3-deoxy-D-manno-octulosonic-acid transferase 4242704..4243981 Escherichia coli ED1a 7139176 YP_002400130.1 CDS coaD NC_011745.1 4243989 4244468 D Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 4243989..4244468 Escherichia coli ED1a 7142502 YP_002400131.1 CDS mutM NC_011745.1 4244507 4245316 R Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase complement(4244507..4245316) Escherichia coli ED1a 7142029 YP_002400132.1 CDS rpmG NC_011745.1 4245414 4245581 R in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 complement(4245414..4245581) Escherichia coli ED1a 7139056 YP_002400133.1 CDS rpmB NC_011745.1 4245602 4245838 R required for 70S ribosome assembly; 50S ribosomal protein L28 complement(4245602..4245838) Escherichia coli ED1a 7141481 YP_002400134.1 CDS radC NC_011745.1 4246055 4246723 R Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC complement(4246055..4246723) Escherichia coli ED1a 7141476 YP_002400135.1 CDS dfp NC_011745.1 4246895 4248115 D catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 4246895..4248115 Escherichia coli ED1a 7139725 YP_002400136.1 CDS dut NC_011745.1 4248096 4248551 D catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 4248096..4248551 Escherichia coli ED1a 7143100 YP_002400137.1 CDS slmA NC_011745.1 4248658 4249254 D FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly; nucleoid occlusion protein 4248658..4249254 Escherichia coli ED1a 7142742 YP_002400138.1 CDS pyrE NC_011745.1 4249291 4249932 R involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase complement(4249291..4249932) Escherichia coli ED1a 7140841 YP_002400139.1 CDS rph NC_011745.1 4249998 4250738 R RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH complement(4249998..4250738) Escherichia coli ED1a 7141234 YP_002400140.1 CDS yicC NC_011745.1 4250841 4251704 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4250841..4251704 Escherichia coli ED1a 7141448 YP_002400141.1 CDS yicG NC_011745.1 4251956 4252573 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4251956..4252573 Escherichia coli ED1a 7139715 YP_002400142.1 CDS ligB NC_011745.1 4252570 4254252 R this ligase is similar to LigA but it lacks the C-terminal BRCT domain; catalyzes strand joining of nicked DNA in the presence of a divalent cation and NAD+; NAD-dependent DNA ligase LigB complement(4252570..4254252) Escherichia coli ED1a 7139717 YP_002400143.1 CDS gmk NC_011745.1 4254510 4255133 D Essential for recycling GMP and indirectly, cGMP; guanylate kinase 4254510..4255133 Escherichia coli ED1a 7141886 YP_002400144.1 CDS rpoZ NC_011745.1 4255188 4255463 D promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 4255188..4255463 Escherichia coli ED1a 7142995 YP_002400145.1 CDS spoT NC_011745.1 4255482 4257590 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12224635, 89255395, 93266525, 94068533, 2005134, 2549050; Product type e : enzyme; bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 4255482..4257590 Escherichia coli ED1a 7140082 YP_002400146.1 CDS trmH NC_011745.1 4257597 4258286 D specifically modifies tRNA at position G18; tRNA guanosine-2'-O-methyltransferase 4257597..4258286 Escherichia coli ED1a 7143831 YP_002400147.1 CDS recG NC_011745.1 4258292 4260373 D catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 4258292..4260373 Escherichia coli ED1a 7140817 YP_002400148.1 CDS gltS NC_011745.1 4260407 4261612 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91203811, 93106943, 1544582, 2017136, 2254324; Product type t : transporter; glutamate transporter complement(4260407..4261612) Escherichia coli ED1a 7141579 YP_002400149.1 CDS yicE NC_011745.1 4261892 4263283 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 4261892..4263283 Escherichia coli ED1a 7142986 YP_002400150.1 CDS yicH NC_011745.1 4263404 4265113 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4263404..4265113 Escherichia coli ED1a 7139716 YP_002400151.1 CDS ECED1_4341 NC_011745.1 4265157 4265876 R Evidence 4 : Homologs of previously reported genes of unknown function; putative sugar related regulatory protein complement(4265157..4265876) Escherichia coli ED1a 7139718 YP_002400152.1 CDS ECED1_4342 NC_011745.1 4265818 4266783 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sugar kinase/transcriptional regulator. ATPase domain complement(4265818..4266783) Escherichia coli ED1a 7142324 YP_002400153.1 CDS ECED1_4343 NC_011745.1 4266798 4267658 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein complement(4266798..4267658) Escherichia coli ED1a 7142325 YP_002400154.1 CDS ECED1_4344 NC_011745.1 4267739 4268590 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sugar aldolase complement(4267739..4268590) Escherichia coli ED1a 7142326 YP_002400155.1 CDS ECED1_4345 NC_011745.1 4268602 4269693 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative phosphotransferase system, fructose-specific IIC component complement(4268602..4269693) Escherichia coli ED1a 7142327 YP_002400156.1 CDS ECED1_4346 NC_011745.1 4269718 4270032 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative phosphotransferase system, fructose-specific IIB subunit complement(4269718..4270032) Escherichia coli ED1a 7142328 YP_002400157.1 CDS ECED1_4347 NC_011745.1 4270050 4270520 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative phosphotransferase system (PTS), fructose-specific IIA component complement(4270050..4270520) Escherichia coli ED1a 7142329 YP_002400158.1 CDS ECED1_4348 NC_011745.1 4270547 4272100 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative PTS system transcriptional antiterminator complement(4270547..4272100) Escherichia coli ED1a 7142330 YP_002400159.1 CDS yicI NC_011745.1 4272395 4274713 R catalyzes the transfer of alpha-xylosyl residue from alpha-xyloside to xylose, glucose, mannose, fructose, maltose, isomaltose, nigerose, kojibiose, sucrose, and trehalose; shows higher activity against alpha-xylosyl fluoride, isoprimeverose (6-O-alpha-xylopyranosyl-glucopyranose), and alpha-xyloside in xyloglucan oligosaccharides; alpha-xylosidase YicI complement(4272395..4274713) Escherichia coli ED1a 7142331 YP_002400160.1 CDS yicJ NC_011745.1 4274723 4276105 R may be involved in the transport of galactosides-pentoses-hexuronides; putative transporter complement(4274723..4276105) Escherichia coli ED1a 7139719 YP_002400161.1 CDS ECED1_4351 NC_011745.1 4276416 4277582 D Evidence 4 : Homologs of previously reported genes of unknown function; putative RhuM-like cytoplasmic protein 4276416..4277582 Escherichia coli ED1a 7140579 YP_002400162.1 CDS ECED1_4352 NC_011745.1 4278152 4278649 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4278152..4278649 Escherichia coli ED1a 7142332 YP_002400163.1 CDS yicL NC_011745.1 4278816 4279739 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4278816..4279739 Escherichia coli ED1a 7142333 YP_002400164.1 CDS nlpA NC_011745.1 4279743 4280561 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88298691, 89359178, 9914480, 3003106; Product type lp : lipoprotein; cytoplasmic membrane lipoprotein-28 complement(4279743..4280561) Escherichia coli ED1a 7139721 YP_002400165.1 CDS yicS NC_011745.1 4280714 4281076 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4280714..4281076 Escherichia coli ED1a 7140397 YP_002400166.1 CDS nepI NC_011745.1 4281117 4282472 R experimental results in Escherichia coli suggest that this gene encodes an inosine export protein; member of major facilitator superfamily; MFS; ribonucleoside transporter complement(4281117..4282472) Escherichia coli ED1a 7139726 YP_002400167.1 CDS yicN NC_011745.1 4282518 4282970 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4282518..4282970) Escherichia coli ED1a 7139722 YP_002400168.1 CDS yicO NC_011745.1 4283023 4284357 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative xanthine/uracil permease complement(4283023..4284357) Escherichia coli ED1a 7139723 YP_002400169.1 CDS ade NC_011745.1 4284532 4286298 D catalyzes the formation of hypoxanthine from adenine; in E. coli this activity has been detected in mutant strains but not in wild type; cryptic adenine deaminase 4284532..4286298 Escherichia coli ED1a 7139724 YP_002400170.1 CDS uhpT NC_011745.1 4286344 4287735 R cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate; sugar phosphate antiporter complement(4286344..4287735) Escherichia coli ED1a 7143659 YP_002400171.1 CDS uhpC NC_011745.1 4287873 4289192 R membrane protein regulates uhpT expression; regulatory protein UhpC complement(4287873..4289192) Escherichia coli ED1a 7138881 YP_002400172.1 CDS uhpB NC_011745.1 4289202 4290704 R Member of the two-component regulatory system UhpB/UhpA involved in the regulation of the uptake of hexose ph; sensory histidine kinase UhpB complement(4289202..4290704) Escherichia coli ED1a 7138880 YP_002400173.1 CDS uhpA NC_011745.1 4290704 4291294 R response regulator in two-component regulatory system wtih UhpB; phosphorylated UhpA is a positive activator uhpT, a hexose phosphates transporter; DNA-binding transcriptional activator UhpA complement(4290704..4291294) Escherichia coli ED1a 7138879 YP_002400174.1 CDS ECED1_4365 NC_011745.1 4291709 4292569 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4291709..4292569 Escherichia coli ED1a 7138878 YP_002400175.1 CDS ilvN NC_011745.1 4292760 4293050 R with IlvB catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase small subunit; acetolactate synthase 1 regulatory subunit complement(4292760..4293050) Escherichia coli ED1a 7142334 YP_002400176.1 CDS ilvB NC_011745.1 4293054 4294742 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 2989782, 85242083, 92380929, 2989781; Product type e : enzyme; acetolactate synthase catalytic subunit complement(4293054..4294742) Escherichia coli ED1a 7141105 YP_002400177.1 CDS ivbL NC_011745.1 4294848 4294946 R Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide; ilvB operon leader peptide complement(4294848..4294946) Escherichia coli ED1a 7140236 YP_002400178.1 CDS emrD NC_011745.1 4295347 4296531 D multidrug efflux protein involved in adaptation to low energy shock; multidrug resistance protein D 4295347..4296531 Escherichia coli ED1a 7142476 YP_002400179.1 CDS yidF NC_011745.1 4296539 4297036 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(4296539..4297036) Escherichia coli ED1a 7139787 YP_002400180.1 CDS yidG NC_011745.1 4297033 4297395 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(4297033..4297395) Escherichia coli ED1a 7139732 YP_002400181.1 CDS yidH NC_011745.1 4297385 4297732 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(4297385..4297732) Escherichia coli ED1a 7139733 YP_002400182.1 CDS yidJ NC_011745.1 4297792 4299285 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sulfatase/phosphatase complement(4297792..4299285) Escherichia coli ED1a 7139734 YP_002400183.1 CDS yidK NC_011745.1 4299282 4300997 R uncharacterized member of the SSS superfamily of sodium-dependent solute transporters; unknown function; putative symporter YidK complement(4299282..4300997) Escherichia coli ED1a 7139735 YP_002400184.1 CDS yidL NC_011745.1 4301134 4302030 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 4301134..4302030 Escherichia coli ED1a 7139736 YP_002400185.1 CDS yidE NC_011745.1 4302120 4303781 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1356969; Product type pt : putative transporter; hypothetical protein complement(4302120..4303781) Escherichia coli ED1a 7139737 YP_002400186.1 CDS ibpB NC_011745.1 4303978 4304406 R 16 kDa heat shock protein B; associates with aggregated proteins, together with ibpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; ATP-independent; heat shock chaperone IbpB complement(4303978..4304406) Escherichia coli ED1a 7139731 YP_002400187.1 CDS ibpA NC_011745.1 4304518 4304931 R with IbpB associates with aggregated proteins to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; heat shock protein IbpA complement(4304518..4304931) Escherichia coli ED1a 7140216 YP_002400188.1 CDS yidQ NC_011745.1 4305237 4305569 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4305237..4305569 Escherichia coli ED1a 7140215 YP_002400189.1 CDS yidR NC_011745.1 4305573 4306787 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4305573..4306787) Escherichia coli ED1a 7139738 YP_002400190.1 CDS cbrA NC_011745.1 4306867 4307988 D FAD/NAD(P)-binding domain; putative oxidoreductase 4306867..4307988 Escherichia coli ED1a 7139739 YP_002400191.1 CDS dgoT NC_011745.1 4307949 4309241 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 79020349; Product type t : transporter; D-galactonate transporter complement(4307949..4309241) Escherichia coli ED1a 7139311 YP_002400192.1 CDS dgoD NC_011745.1 4309361 4310509 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 79020349; Product type e : enzyme; galactonate dehydratase complement(4309361..4310509) Escherichia coli ED1a 7143107 YP_002400193.1 CDS dgoA NC_011745.1 4310506 4311123 R catalyzes the formation of D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-galactonate 6-phosphate; functions in galactonate metabolism; 2-dehydro-3-deoxy-6-phosphogalactonate aldolase complement(4310506..4311123) Escherichia coli ED1a 7143104 YP_002400194.1 CDS dgoK NC_011745.1 4311107 4311985 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 79020349; Product type e : enzyme; 2-oxo-3-deoxygalactonate kinase complement(4311107..4311985) Escherichia coli ED1a 7143103 YP_002400195.1 CDS dgoR NC_011745.1 4311982 4312671 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 79020349; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(4311982..4312671) Escherichia coli ED1a 7143105 YP_002400196.1 CDS yidX NC_011745.1 4312932 4313606 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein 4312932..4313606 Escherichia coli ED1a 7143106 YP_002400197.1 CDS yidA NC_011745.1 4313650 4314462 R YidA; catalyzes the dephosphorylation of erythrose 4-phosphate (preferred substrate), mannose 1-phosphate and p-nitrophenyl phosphate; hydrolyzes the alpha-D-glucose-1-phosphate but not the beta form; member of the haloacid dehalogenase-like hydrolases superfamily and Cof family of proteins; sugar phosphatase complement(4313650..4314462) Escherichia coli ED1a 7139740 YP_002400198.1 CDS yidB NC_011745.1 4314577 4314975 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4314577..4314975) Escherichia coli ED1a 7139727 YP_002400199.1 CDS gyrB NC_011745.1 4315215 4317629 R negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B complement(4315215..4317629) Escherichia coli ED1a 7139728 YP_002400200.1 CDS recF NC_011745.1 4317658 4318731 R Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F complement(4317658..4318731) Escherichia coli ED1a 7139853 YP_002400201.1 CDS dnaN NC_011745.1 4318731 4319831 R binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta complement(4318731..4319831) Escherichia coli ED1a 7141578 YP_002400202.1 CDS dnaA NC_011745.1 4319836 4321239 R binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein complement(4319836..4321239) Escherichia coli ED1a 7140509 YP_002400203.1 CDS rpmH NC_011745.1 4321846 4321986 D in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 4321846..4321986 Escherichia coli ED1a 7140502 YP_002400204.1 CDS rnpA NC_011745.1 4322003 4322362 D protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 4322003..4322362 Escherichia coli ED1a 7141482 YP_002400205.1 CDS yidD NC_011745.1 4322326 4322583 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4322326..4322583 Escherichia coli ED1a 7141440 YP_002400206.1 CDS yidC NC_011745.1 4322586 4324232 D functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; putative inner membrane protein translocase component YidC 4322586..4324232 Escherichia coli ED1a 7139730 YP_002400207.1 CDS trmE NC_011745.1 4324338 4325702 D in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 4324338..4325702 Escherichia coli ED1a 7139729 YP_002400208.1 CDS tnaC NC_011745.1 4325944 4326018 D Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide; tryptophanase leader peptide 4325944..4326018 Escherichia coli ED1a 7140816 YP_002400209.1 CDS tnaA NC_011745.1 4326239 4327654 D tryptophan indole-lyase; catalyzes the formation of indole and pyruvate from tryptophan; tryptophanase 4326239..4327654 Escherichia coli ED1a 7141565 YP_002400210.1 CDS tnaB NC_011745.1 4327746 4328993 D tryptophan transporter of low affinity; tryptophan permease TnaB 4327746..4328993 Escherichia coli ED1a 7141563 YP_002400211.1 CDS mdtL NC_011745.1 4329125 4330300 D Confers resistance to chloramphenicol; multidrug efflux system protein MdtL 4329125..4330300 Escherichia coli ED1a 7141564 YP_002400212.1 CDS yidZ NC_011745.1 4330275 4331234 D Involved in anaerobic NO protection; DNA-binding transcriptional regulator YidZ 4330275..4331234 Escherichia coli ED1a 7142238 YP_002400213.1 CDS yieE NC_011745.1 4331379 4332140 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphopantetheinyl transferase 4331379..4332140 Escherichia coli ED1a 7139741 YP_002400214.1 CDS yieF NC_011745.1 4332162 4332728 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14766567; Product type e : enzyme; chromate reductase, Class I, flavoprotein 4332162..4332728 Escherichia coli ED1a 7139742 YP_002400215.1 CDS yieG NC_011745.1 4332781 4334118 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(4332781..4334118) Escherichia coli ED1a 7139743 YP_002400216.1 CDS yieH NC_011745.1 4334285 4334950 D YieH; catalyzes the dephosphorylation of phosphoenolpyruvate, AMP and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; member of the haloacid dehalogenase-like hydrolases superfamily; 6-phosphogluconate phosphatase 4334285..4334950 Escherichia coli ED1a 7139744 YP_002400217.1 CDS yieI NC_011745.1 4335017 4335490 D might be involved in hypersensitivity to nitrofurzone; putative inner membrane protein 4335017..4335490 Escherichia coli ED1a 7139745 YP_002400218.1 CDS yieK NC_011745.1 4335572 4336294 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative 6-phosphogluconolactonase complement(4335572..4336294) Escherichia coli ED1a 7139746 YP_002400219.1 CDS yieL NC_011745.1 4336309 4337505 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative xylanase complement(4336309..4337505) Escherichia coli ED1a 7139747 YP_002400220.1 CDS bglH NC_011745.1 4337505 4339121 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10027967; Product type t : transporter; carbohydrate-specific outer membrane porin, cryptic complement(4337505..4339121) Escherichia coli ED1a 7139748 YP_002400221.1 CDS bglB NC_011745.1 4339207 4340601 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87222180, 88297127, 92334140, 3034860, 3309161; Product type e : enzyme; cryptic phospho-beta-glucosidase B complement(4339207..4340601) Escherichia coli ED1a 7140447 YP_002400222.1 CDS bglF NC_011745.1 4340620 4342569 R phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system beta-glucoside-specific transporter subunits IIABC complement(4340620..4342569) Escherichia coli ED1a 7140444 YP_002400223.1 CDS bglG NC_011745.1 4342628 4343464 R positive regulator of the beta-glucoside operon; transcriptional antiterminator; transcriptional antiterminator BglG complement(4342628..4343464) Escherichia coli ED1a 7140445 YP_002400224.1 CDS phoU NC_011745.1 4343750 4344475 R regulates several genes involved in high affinity phosphate uptake; under conditions of high phosphate concentrations downregulates the PHO regulon; transcriptional regulator PhoU complement(4343750..4344475) Escherichia coli ED1a 7140446 YP_002400225.1 CDS pstB NC_011745.1 4344490 4345263 R ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein complement(4344490..4345263) Escherichia coli ED1a 7144109 YP_002400226.1 CDS pstA NC_011745.1 4345354 4346244 R Part of the ABC transporter complex PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease subunit PtsA complement(4345354..4346244) Escherichia coli ED1a 7141198 YP_002400227.1 CDS pstC NC_011745.1 4346244 4347203 R part of the ATP-dependent phosphate uptake system PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease subunit PstC complement(4346244..4347203) Escherichia coli ED1a 7141197 YP_002400228.1 CDS pstS NC_011745.1 4347290 4348330 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90133909, 2215649, 6321434, 6365894, 9228942, 9298646, 9671506; Product type t : transporter; phosphate ABC transporter periplasmic substrate-binding protein PstS complement(4347290..4348330) Escherichia coli ED1a 7141199 YP_002400229.1 CDS glmS NC_011745.1 4348644 4350473 R Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase complement(4348644..4350473) Escherichia coli ED1a 7141200 YP_002400230.1 CDS glmU NC_011745.1 4350634 4352004 R forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase complement(4350634..4352004) Escherichia coli ED1a 7143193 YP_002400231.1 CDS atpC NC_011745.1 4352358 4352777 R part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon complement(4352358..4352777) Escherichia coli ED1a 7143194 YP_002400232.1 CDS atpD NC_011745.1 4352798 4354180 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta complement(4352798..4354180) Escherichia coli ED1a 7140410 YP_002400233.1 CDS atpG NC_011745.1 4354207 4355070 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma complement(4354207..4355070) Escherichia coli ED1a 7140411 YP_002400234.1 CDS atpA NC_011745.1 4355121 4356662 R produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha complement(4355121..4356662) Escherichia coli ED1a 7140414 YP_002400235.1 CDS atpH NC_011745.1 4356675 4357208 R Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta complement(4356675..4357208) Escherichia coli ED1a 7140408 YP_002400236.1 CDS atpF NC_011745.1 4357223 4357693 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B complement(4357223..4357693) Escherichia coli ED1a 7140415 YP_002400237.1 CDS atpE NC_011745.1 4357755 4357994 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C complement(4357755..4357994) Escherichia coli ED1a 7140413 YP_002400238.1 CDS atpB NC_011745.1 4358041 4358856 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A complement(4358041..4358856) Escherichia coli ED1a 7140412 YP_002400239.1 CDS atpI NC_011745.1 4358865 4359245 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation; F0F1 ATP synthase subunit I complement(4358865..4359245) Escherichia coli ED1a 7140409 YP_002400240.1 CDS gidB NC_011745.1 4359862 4360485 R glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB complement(4359862..4360485) Escherichia coli ED1a 7140416 YP_002400241.1 CDS gidA NC_011745.1 4360549 4362438 R GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA complement(4360549..4362438) Escherichia coli ED1a 7143177 YP_002400242.1 CDS mioC NC_011745.1 4362817 4363260 R An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin complement(4362817..4363260) Escherichia coli ED1a 7143176 YP_002400243.1 CDS asnC NC_011745.1 4363350 4363808 R transcriptional repressor of asnA which codes for aspartate-ammonia ligase; DNA-binding transcriptional regulator AsnC complement(4363350..4363808) Escherichia coli ED1a 7138987 YP_002400244.1 CDS asnA NC_011745.1 4363960 4364952 D catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA 4363960..4364952 Escherichia coli ED1a 7142647 YP_002400245.1 CDS yieM NC_011745.1 4364957 4366408 R contains a von Willibrand factor type A domain; stimulates the ATPase activity of RavA; hypothetical protein complement(4364957..4366408) Escherichia coli ED1a 7142645 YP_002400246.1 CDS ravA NC_011745.1 4366402 4367898 R interacts with LdcI, lysine decarboxylase; may be active in late log/ early stationary phase; regulatory ATPase RavA complement(4366402..4367898) Escherichia coli ED1a 7139749 YP_002400247.1 CDS trkD NC_011745.1 4368121 4369989 D Responsible for the low-affinity transport of potassium into the cell; involved in potassium ion uptake under hyper-osmotic stress at a low pH; potassium transport protein Kup 4368121..4369989 Escherichia coli ED1a 7141252 YP_002400248.1 CDS rbsD NC_011745.1 4370156 4370575 D cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source; D-ribose pyranase 4370156..4370575 Escherichia coli ED1a 7140811 YP_002400249.1 CDS rbsA NC_011745.1 4370583 4372088 D with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain; D-ribose transporter ATP binding protein 4370583..4372088 Escherichia coli ED1a 7141259 YP_002400250.1 CDS rbsC NC_011745.1 4372093 4373058 D functions to transport ribose at high affinity; forms a complex with RbsA2C2B; ribose ABC transporter permease 4372093..4373058 Escherichia coli ED1a 7141256 YP_002400251.1 CDS rbsB NC_011745.1 4373083 4373973 D periplasmic substrate-binding component of the ATP-dependent ribose transport system; D-ribose transporter subunit RbsB 4373083..4373973 Escherichia coli ED1a 7141258 YP_002400252.1 CDS rbsK NC_011745.1 4374099 4375028 D catalyzes the formation of D-ribose 5-phosphate from ribose; ribokinase 4374099..4375028 Escherichia coli ED1a 7141257 YP_002400253.1 CDS rbsR NC_011745.1 4375032 4376024 D DNA-binding transcriptional repressor of ribose metabolism; transcriptional repressor RbsR 4375032..4376024 Escherichia coli ED1a 7141260 YP_002400254.1 CDS hsrA NC_011745.1 4375990 4377417 R Evidence 2b : Function of strongly homologous gene; PubMedId : 20218988, 12107133; Product type t : transporter; multidrug or homocysteine efflux system complement(4375990..4377417) Escherichia coli ED1a 7141261 YP_002400255.1 CDS yieP NC_011745.1 4377440 4378132 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator complement(4377440..4378132) Escherichia coli ED1a 7140171 YP_002400256.1 CDS hdfR NC_011745.1 4383930 4384769 R Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon; transcriptional regulator HdfR complement(4383930..4384769) Escherichia coli ED1a 7140582 YP_002400257.1 CDS yifE NC_011745.1 4384888 4385226 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4384888..4385226 Escherichia coli ED1a 7139862 YP_002400258.1 CDS yifB NC_011745.1 4385251 4386801 R among the AAA+ ATPases, the YifB protease family belongs to the Helix 2 insert clade; unknown function; putative ATP-dependent protease complement(4385251..4386801) Escherichia coli ED1a 7139752 YP_002400259.1 CDS ilvL NC_011745.1 4387124 4387222 D Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide; ilvG operon leader peptide 4387124..4387222 Escherichia coli ED1a 7139751 YP_002400260.1 CDS ilvG NC_011745.1 4387362 4389008 D catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; acetolactate synthase 2 catalytic subunit 4387362..4389008 Escherichia coli ED1a 7141705 YP_002400261.1 CDS ilvM NC_011745.1 4389005 4389268 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92332418, 92380929, 1569580, 3550695, 3897211; Product type e : enzyme; acetolactate synthase 2 regulatory subunit 4389005..4389268 Escherichia coli ED1a 7140240 YP_002400262.1 CDS ilvE NC_011745.1 4389288 4390217 D catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 4389288..4390217 Escherichia coli ED1a 7141104 YP_002400263.1 CDS ilvD NC_011745.1 4390282 4392132 D catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 4390282..4392132 Escherichia coli ED1a 7140239 YP_002400264.1 CDS ilvA NC_011745.1 4392135 4393679 D threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway; threonine dehydratase 4392135..4393679 Escherichia coli ED1a 7140238 YP_002400265.1 CDS ilvY NC_011745.1 4393676 4394650 R participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate; DNA-binding transcriptional regulator IlvY complement(4393676..4394650) Escherichia coli ED1a 7140235 YP_002400266.1 CDS ilvC NC_011745.1 4394716 4396191 D catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 4394716..4396191 Escherichia coli ED1a 7141106 YP_002400267.1 CDS ppiC NC_011745.1 4396237 4396518 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94215709, 7878732, 7925971, 8163020; Product type e : enzyme; peptidyl-prolyl cis-trans isomerase C complement(4396237..4396518) Escherichia coli ED1a 7140237 YP_002400268.1 CDS rep NC_011745.1 4396605 4398626 D single-stranded DNA-dependent ATPase; initiates unwinding at a nick in the DNA; involved in DNA replication; ATP-dependent DNA helicase Rep 4396605..4398626 Escherichia coli ED1a 7139105 YP_002400269.1 CDS gpp NC_011745.1 4398673 4400157 R catalyzes the conversion of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) to guanosine 5'-diphosphate,3'-diphosphate (ppGpp); pppGpp and ppGpp control the stringent response during amino acid starvation; guanosine pentaphosphate phosphohydrolase complement(4398673..4400157) Escherichia coli ED1a 7141589 YP_002400270.1 CDS ECED1_4464 NC_011745.1 4400163 4400342 R Evidence 6 : Doubtful CDS; hypothetical protein complement(4400163..4400342) Escherichia coli ED1a 7143014 YP_002400271.1 CDS rhlB NC_011745.1 4400293 4401558 R enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation; ATP-dependent RNA helicase RhlB complement(4400293..4401558) Escherichia coli ED1a 7142335 YP_002400272.1 CDS trxA NC_011745.1 4401689 4402018 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90202710, 91154193, 92250497, 99175138, 10489448, 1094461, 10947986, 1561103, 2181145, 2193685, 3891733, 4616096, 4883076, 6098320, 6099324, 7812718, 8098620, 8253691; Product type c : carrier; thioredoxin 4401689..4402018 Escherichia coli ED1a 7141613 YP_002400273.1 CDS rhoL NC_011745.1 4402159 4402260 D Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide; putative rho operon leader peptide 4402159..4402260 Escherichia coli ED1a 7140831 YP_002400274.1 CDS rho NC_011745.1 4402345 4403604 D An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 4402345..4403604 Escherichia coli ED1a 7141616 YP_002400275.1 CDS rfe NC_011745.1 4403844 4404947 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92114763, 94245613, 94292435, 10629198, 11024259, 11700352, 11832520, 1722555, 1730666; Product type e : enzyme; UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase 4403844..4404947 Escherichia coli ED1a 7141615 YP_002400276.1 CDS wzzE NC_011745.1 4404959 4406005 D Enterobacterial Common Antigen (ECA) polysaccharide chain length modulation protein; lipopolysaccharide biosynthesis protein WzzE 4404959..4406005 Escherichia coli ED1a 7141598 YP_002400277.1 CDS rffE NC_011745.1 4406061 4407191 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90212314, 90337949, 92112804, 94042873, 11106477, 7559340, 8170390, 8226648; Product type e : enzyme; UDP-N-acetyl glucosamine-2-epimerase 4406061..4407191 Escherichia coli ED1a 7139196 YP_002400278.1 CDS wecC NC_011745.1 4407188 4408450 D catalyzes the oxidation of UDP-N-acetyl-D-mannosamine to UDP-N-acetylmannosaminuronic acid; UDP-N-acetyl-D-mannosamine dehydrogenase 4407188..4408450 Escherichia coli ED1a 7141602 YP_002400279.1 CDS rffG NC_011745.1 4408450 4409517 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88086930, 90212314, 90337949, 92112804, 92174908, 94018634, 94042873, 7559340; Product type e : enzyme; dTDP-glucose 4,6-dehydratase 4408450..4409517 Escherichia coli ED1a 7141601 YP_002400280.1 CDS rffH NC_011745.1 4409536 4410417 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94292435, 96032389; Product type e : enzyme; glucose-1-phosphate thymidylyltransferase 4409536..4410417 Escherichia coli ED1a 7141603 YP_002400281.1 CDS rffC NC_011745.1 4410395 4411069 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90212314, 90337949, 92112804, 8366065; Product type e : enzyme; TDP-fucosamine acetyltransferase 4410395..4411069 Escherichia coli ED1a 7141604 YP_002400282.1 CDS rffA NC_011745.1 4411074 4412204 D catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis; TDP-4-oxo-6-deoxy-D-glucose transaminase 4411074..4412204 Escherichia coli ED1a 7141600 YP_002400283.1 CDS wzxE NC_011745.1 4412206 4413456 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12621029, 20044778; Product type t : transporter; O-antigen translocase 4412206..4413456 Escherichia coli ED1a 7141599 YP_002400284.1 CDS rffT NC_011745.1 4413453 4414532 D catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis; 4-alpha-L-fucosyltransferase 4413453..4414532 Escherichia coli ED1a 7139194 YP_002400285.1 CDS wzyE NC_011745.1 4414529 4415881 D enterobacterial common antigen polymerase; putative common antigen polymerase 4414529..4415881 Escherichia coli ED1a 7141606 YP_002400286.1 CDS rffM NC_011745.1 4415884 4416624 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88086874, 90337949, 92112804; Product type e : enzyme; putative UDP-N-acetyl-D-mannosaminuronic acid transferase 4415884..4416624 Escherichia coli ED1a 7139195 YP_002400287.1 CDS yifK NC_011745.1 4416815 4418200 D uncharacterized member of the amino acid-polyamine-organocation (APC) superfamily of amino acid transporters; unknown function; putative transport protein YifK 4416815..4418200 Escherichia coli ED1a 7141605 YP_002400288.1 CDS aslB NC_011745.1 4418886 4420121 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11222759, 2180918, 12419807, 14749327; Product type pr : putative regulator; regulator of arylsulfatase activity 4418886..4420121 Escherichia coli ED1a 7140587 YP_002400289.1 CDS aslA NC_011745.1 4420212 4421867 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16766528, 92358234, 15477040; Product type e : enzyme; arylsulfatase-like enzyme complement(4420212..4421867) Escherichia coli ED1a 7142643 YP_002400290.1 CDS hemY NC_011745.1 4422546 4423742 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 89041586; Product type pe : putative enzyme; putative protoheme IX biogenesis protein complement(4422546..4423742) Escherichia coli ED1a 7141353 YP_002400291.1 CDS hemX NC_011745.1 4423745 4424962 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 89098348, 92358234, 3054815, 3062586, 9298646; Product type pe : putative enzyme; putative uroporphyrinogen III C-methyltransferase complement(4423745..4424962) Escherichia coli ED1a 7139876 YP_002400292.1 CDS hemD NC_011745.1 4424984 4425724 R catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis; uroporphyrinogen-III synthase complement(4424984..4425724) Escherichia coli ED1a 7139875 YP_002400293.1 CDS hemC NC_011745.1 4425721 4426662 R transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase complement(4425721..4426662) Escherichia coli ED1a 7139868 YP_002400294.1 CDS cyaA NC_011745.1 4427049 4429595 D catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP; adenylate cyclase 4427049..4429595 Escherichia coli ED1a 7139867 YP_002400295.1 CDS cyaY NC_011745.1 4429635 4429955 R defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly; frataxin-like protein complement(4429635..4429955) Escherichia coli ED1a 7142093 YP_002400296.1 CDS yifL NC_011745.1 4430425 4430628 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; putative lipoprotein 4430425..4430628 Escherichia coli ED1a 7142094 YP_002400297.1 CDS dapF NC_011745.1 4430665 4431489 D involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 4430665..4431489 Escherichia coli ED1a 7139754 YP_002400298.1 CDS yigA NC_011745.1 4431486 4432193 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4431486..4432193 Escherichia coli ED1a 7143066 YP_002400299.1 CDS xerC NC_011745.1 4432190 4433086 D site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC 4432190..4433086 Escherichia coli ED1a 7142276 YP_002400300.1 CDS yigB NC_011745.1 4433086 4433802 D YigB; member of the haloacid dehalogenase (HAD)-like hydrolases superfamily of protein; unknown function; flavin mononucleotide phosphatase 4433086..4433802 Escherichia coli ED1a 7139206 YP_002400301.1 CDS uvrD NC_011745.1 4433886 4436048 D unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair.; DNA-dependent helicase II 4433886..4436048 Escherichia coli ED1a 7142873 YP_002400302.1 CDS ECED1_4499 NC_011745.1 4436103 4437005 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4436103..4437005) Escherichia coli ED1a 7139153 YP_002400303.1 CDS yigE NC_011745.1 4437088 4437852 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4437088..4437852) Escherichia coli ED1a 7142336 YP_002400304.1 CDS corA NC_011745.1 4438222 4439172 D responsible for the influx of magnesium ions; magnesium/nickel/cobalt transporter CorA 4438222..4439172 Escherichia coli ED1a 7142874 YP_002400305.1 CDS ECED1_4502 NC_011745.1 4439208 4439705 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4439208..4439705) Escherichia coli ED1a 7142040 YP_002400306.1 CDS ECED1_4503 NC_011745.1 4439702 4440550 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4439702..4440550) Escherichia coli ED1a 7142337 YP_002400307.1 CDS rarD NC_011745.1 4440860 4441750 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative chloramphenicol resistance permease complement(4440860..4441750) Escherichia coli ED1a 7142338 YP_002400308.1 CDS yigI NC_011745.1 4441802 4442269 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4441802..4442269) Escherichia coli ED1a 7141251 YP_002400309.1 CDS pldA NC_011745.1 4442434 4443303 D catalyzes the hydrolysis of phosphatidylcholine; phospholipase A 4442434..4443303 Escherichia coli ED1a 7142875 YP_002400310.1 CDS recQ NC_011745.1 4443428 4445257 D functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway; ATP-dependent DNA helicase RecQ 4443428..4445257 Escherichia coli ED1a 7139067 YP_002400311.1 CDS rhtC NC_011745.1 4445321 4445941 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99313167, 10386596, 3027506; Product type t : transporter; threonine efflux system 4445321..4445941 Escherichia coli ED1a 7141583 YP_002400312.1 CDS rhtB NC_011745.1 4446002 4446622 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99313167, 10386596; Product type t : transporter; homoserine/homoserine lactone efflux protein complement(4446002..4446622) Escherichia coli ED1a 7141620 YP_002400313.1 CDS pldB NC_011745.1 4446733 4447755 D lecithinase B; catalyzes the conversion of 1-lysophosphatidylcholine to glycerophosphocholine; can also hydrolyze 2-acyl glycerophosphoethanolamine and other substrates; lysophospholipase L2 4446733..4447755 Escherichia coli ED1a 7141619 YP_002400314.1 CDS yigL NC_011745.1 4447763 4448563 D purine and pyrimidine nucleotides are secondary substrates; yigL expression is regulated by heat shock, osmotic shock and starvation of glucose, phosphate or ammonium; putative sugar phosphatase 4447763..4448563 Escherichia coli ED1a 7139068 YP_002400315.1 CDS yigM NC_011745.1 4448639 4449538 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4448639..4449538 Escherichia coli ED1a 7142876 YP_002400316.1 CDS metR NC_011745.1 4449426 4450379 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90384950, 96303520, 2205852, 2643109; Product type r : regulator; DNA-binding transcriptional activator, homocysteine-binding complement(4449426..4450379) Escherichia coli ED1a 7142877 YP_002400317.1 CDS metE NC_011745.1 4450497 4452758 D catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 4450497..4452758 Escherichia coli ED1a 7142262 YP_002400318.1 CDS ECED1_4515 NC_011745.1 4453065 4453655 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4453065..4453655 Escherichia coli ED1a 7142251 YP_002400319.1 CDS ptsG NC_011745.1 4453697 4455205 D Evidence 2b : Function of strongly homologous gene; PubMedId : 9200688; Product type t : transporter; fused glucose-specific PTS enzymes: IIBcomponent and IIC component 4453697..4455205 Escherichia coli ED1a 7142339 YP_002400320.1 CDS ECED1_4517 NC_011745.1 4455256 4457253 D catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 4455256..4457253 Escherichia coli ED1a 7141207 YP_002400321.1 CDS ECED1_4518 NC_011745.1 4457283 4458128 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4457283..4458128) Escherichia coli ED1a 7142340 YP_002400322.1 CDS ECED1_4519 NC_011745.1 4458328 4459233 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcritional regulator complement(4458328..4459233) Escherichia coli ED1a 7142341 YP_002400323.1 CDS ECED1_4520 NC_011745.1 4459311 4460534 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative permease complement(4459311..4460534) Escherichia coli ED1a 7142342 YP_002400324.1 CDS ECED1_4521 NC_011745.1 4460560 4460949 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4460560..4460949) Escherichia coli ED1a 7142343 YP_002400325.1 CDS ECED1_4522 NC_011745.1 4460966 4461922 R catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase complement(4460966..4461922) Escherichia coli ED1a 7142344 YP_002400326.1 CDS ECED1_4523 NC_011745.1 4461915 4463390 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4461915..4463390) Escherichia coli ED1a 7142345 YP_002400327.1 CDS ECED1_4524 NC_011745.1 4463336 4464895 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative succinyl-CoA synthetase subunit alpha complement(4463336..4464895) Escherichia coli ED1a 7142346 YP_002400328.1 CDS ECED1_4525 NC_011745.1 4464990 4465850 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4464990..4465850) Escherichia coli ED1a 7142347 YP_002400329.1 CDS ECED1_4526 NC_011745.1 4465856 4466524 R Evidence 4 : Homologs of previously reported genes of unknown function; putative Isochorismate hydrolase complement(4465856..4466524) Escherichia coli ED1a 7142348 YP_002400330.1 CDS ysgA NC_011745.1 4466781 4467656 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12676709; Product type pe : putative enzyme; putative hydrolase complement(4466781..4467656) Escherichia coli ED1a 7142349 YP_002400331.1 CDS udp NC_011745.1 4467846 4468616 D catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway; uridine phosphorylase 4467846..4468616 Escherichia coli ED1a 7143254 YP_002400332.1 CDS ECED1_4529 NC_011745.1 4468651 4470141 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4468651..4470141) Escherichia coli ED1a 7140867 YP_002400333.1 CDS ECED1_4530 NC_011745.1 4470154 4470663 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative permease subunit complement(4470154..4470663) Escherichia coli ED1a 7142350 YP_002400334.1 CDS ECED1_4531 NC_011745.1 4470677 4471651 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative periplasmic binding protein complement(4470677..4471651) Escherichia coli ED1a 7142351 YP_002400335.1 CDS ECED1_4532 NC_011745.1 4471676 4472305 R catalyzes the formation of D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-galactonate 6-phosphate; functions in galactonate metabolism; 2-dehydro-3-deoxy-6-phosphogalactonate aldolase complement(4471676..4472305) Escherichia coli ED1a 7142352 YP_002400336.1 CDS ECED1_4533 NC_011745.1 4472295 4473299 R Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; acidic carbohydrate kinase complement(4472295..4473299) Escherichia coli ED1a 7142353 YP_002400337.1 CDS ECED1_4534 NC_011745.1 4473323 4474177 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator complement(4473323..4474177) Escherichia coli ED1a 7142354 YP_002400338.1 CDS rmuC NC_011745.1 4474307 4475734 D YigN; nuclease that may cleave DNA structures arising during the recombination of short-inverted repeats and thereby prevents the inversion of the internal sequence; transcription is induced by DNA-damaging agents such as nalidixic acid or mitomycin C in a LexA-dependent manner; DNA recombination protein RmuC 4474307..4475734 Escherichia coli ED1a 7142355 YP_002400339.1 CDS ubiE NC_011745.1 4475829 4476584 D Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase 4475829..4476584 Escherichia coli ED1a 7141429 YP_002400340.1 CDS yigP NC_011745.1 4476598 4477203 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4476598..4477203 Escherichia coli ED1a 7140860 YP_002400341.1 CDS ubiB NC_011745.1 4477200 4478840 D an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions; putative ubiquinone biosynthesis protein UbiB 4477200..4478840 Escherichia coli ED1a 7142878 YP_002400342.1 CDS tatA NC_011745.1 4478919 4479188 D TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase protein A 4478919..4479188 Escherichia coli ED1a 7140857 YP_002400343.1 CDS tatB NC_011745.1 4479192 4479707 D mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase 4479192..4479707 Escherichia coli ED1a 7141512 YP_002400344.1 CDS tatC NC_011745.1 4479710 4480486 D with TatABE forms the twin-arginine translocation complex which is involved in the transport of proteins across the cytoplasmic membrane; twin-arginine protein translocation system subunit TatC 4479710..4480486 Escherichia coli ED1a 7141513 YP_002400345.1 CDS tatD NC_011745.1 4480528 4481310 D magnesium dependent; not involved in the Sec-independent protein export system; DNase TatD 4480528..4481310 Escherichia coli ED1a 7141514 YP_002400346.1 CDS rfaH NC_011745.1 4481307 4481795 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92011415, 92250420, 92261317, 1584020, 12007406; Product type r : regulator; transcriptional activator RfaH complement(4481307..4481795) Escherichia coli ED1a 7141515 YP_002400347.1 CDS ubiD NC_011745.1 4481962 4483455 D catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol; 3-octaprenyl-4-hydroxybenzoate decarboxylase 4481962..4483455 Escherichia coli ED1a 7141592 YP_002400348.1 CDS fre NC_011745.1 4483501 4484202 D NAD(P)H-flavin reductase; catalyzes the reversible oxidation/reduction of NAD(P) and flavine mononucleotide; in Salmonella and E. coli this protein also reduces aquacob(III)alamin to cob(II)alamin; FMN reductase 4483501..4484202 Escherichia coli ED1a 7140859 YP_002400349.1 CDS fadA NC_011745.1 4484484 4485647 R FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; 3-ketoacyl-CoA thiolase complement(4484484..4485647) Escherichia coli ED1a 7142170 YP_002400350.1 CDS fadB NC_011745.1 4485657 4487846 R includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; multifunctional fatty acid oxidation complex subunit alpha complement(4485657..4487846) Escherichia coli ED1a 7144124 YP_002400351.1 CDS pepQ NC_011745.1 4488036 4489367 D catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters; proline dipeptidase 4488036..4489367 Escherichia coli ED1a 7144125 YP_002400352.1 CDS yigZ NC_011745.1 4489367 4489981 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15103642; Product type pf : putative factor; hypothetical protein 4489367..4489981 Escherichia coli ED1a 7144064 YP_002400353.1 CDS trkH NC_011745.1 4490020 4491471 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91100357, 2243799, 7896723; Product type t : transporter; potassium transporter 4490020..4491471 Escherichia coli ED1a 7142879 YP_002400354.1 CDS hemG NC_011745.1 4491483 4492028 D catalyzes the oxidation of protoporphyrinogen IX to form protoporphyrin IX; protoporphyrinogen oxidase 4491483..4492028 Escherichia coli ED1a 7140812 YP_002400355.1 CDS mobB NC_011745.1 4497608 4498120 R in Escherichia coli the MobB protein is not essential but has been found to interact with multiple proteins involved in the molybdopterin guanine dinucleotide cofactor biosynthesis pathway; molybdopterin-guanine dinucleotide biosynthesis protein B complement(4497608..4498120) Escherichia coli ED1a 7140740 YP_002400356.1 CDS mobA NC_011745.1 4498117 4498701 R in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis; molybdopterin-guanine dinucleotide biosynthesis protein MobA complement(4498117..4498701) Escherichia coli ED1a 7139002 YP_002400357.1 CDS yihD NC_011745.1 4498771 4499040 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4498771..4499040 Escherichia coli ED1a 7139001 YP_002400358.1 CDS yihE NC_011745.1 4499117 4500103 D catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages; serine/threonine protein kinase 4499117..4500103 Escherichia coli ED1a 7142881 YP_002400359.1 CDS dsbA NC_011745.1 4500120 4500746 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12498799, 93264419, 94016574, 94206930, 99298180, 10210188, 1429594, 1740115, 1934062, 8413591, 8494885, 8521518, 9194175, 9298646, 9300489, 9572841, 9600841, 9655827; Product type e : enzyme; periplasmic protein disulfide isomerase I 4500120..4500746 Escherichia coli ED1a 7142882 YP_002400360.1 CDS yihF NC_011745.1 4500901 4502331 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4500901..4502331 Escherichia coli ED1a 7140521 YP_002400361.1 CDS yihG NC_011745.1 4502372 4503304 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acyltransferase complement(4502372..4503304) Escherichia coli ED1a 7142883 YP_002400362.1 CDS polA NC_011745.1 4503668 4506454 D has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 4503668..4506454 Escherichia coli ED1a 7142884 YP_002400363.1 CDS engB NC_011745.1 4506836 4507432 R binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC complement(4506836..4507432) Escherichia coli ED1a 7143830 YP_002400364.1 CDS yihI NC_011745.1 4508050 4508559 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4508050..4508559 Escherichia coli ED1a 7142077 YP_002400365.1 CDS hemN NC_011745.1 4508748 4510121 D catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 4508748..4510121 Escherichia coli ED1a 7142885 YP_002400366.1 CDS glnG NC_011745.1 4510576 4511985 R response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes; interacts with sigma-54; nitrogen regulation protein NR(I) complement(4510576..4511985) Escherichia coli ED1a 7139874 YP_002400367.1 CDS glnL NC_011745.1 4511997 4513046 R sensory histidine kinase in two-component regulatory system with GlnG; acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC by phosphorylation/dephosphorylation; nitrogen regulation protein NR(II) complement(4511997..4513046) Escherichia coli ED1a 7142957 YP_002400368.1 CDS glnA NC_011745.1 4513220 4514629 R forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme; glutamine synthetase complement(4513220..4514629) Escherichia coli ED1a 7142960 YP_002400369.1 CDS ECED1_4572 NC_011745.1 4514763 4514909 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4514763..4514909) Escherichia coli ED1a 7143195 YP_002400370.1 CDS bipA NC_011745.1 4515002 4516825 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9642082, 7783627, 9298646, 9622352; Product type f : factor; GTP-binding protein 4515002..4516825 Escherichia coli ED1a 7142356 YP_002400371.1 CDS ompL NC_011745.1 4516927 4517619 R porin involved in the transport of small molecular weight solutes (up to 600 Daltons) across the cell wall; specific substrate still unknown; outer membrane porin L complement(4516927..4517619) Escherichia coli ED1a 7140456 YP_002400372.1 CDS yihO NC_011745.1 4517687 4519090 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter complement(4517687..4519090) Escherichia coli ED1a 7139971 YP_002400373.1 CDS yihP NC_011745.1 4519133 4520551 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter complement(4519133..4520551) Escherichia coli ED1a 7142886 YP_002400374.1 CDS yihQ NC_011745.1 4520564 4522600 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15294295; Product type e : enzyme; alpha-glucosidase complement(4520564..4522600) Escherichia coli ED1a 7142887 YP_002400375.1 CDS ECED1_4578 NC_011745.1 4522706 4523581 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative permease complement(4522706..4523581) Escherichia coli ED1a 7142888 YP_002400376.1 CDS yihR NC_011745.1 4523642 4524544 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative aldose-1-epimerase complement(4523642..4524544) Escherichia coli ED1a 7142357 YP_002400377.1 CDS yihS NC_011745.1 4524611 4525852 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glucosamine isomerase complement(4524611..4525852) Escherichia coli ED1a 7142889 YP_002400378.1 CDS yihT NC_011745.1 4525868 4526746 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative aldolase complement(4525868..4526746) Escherichia coli ED1a 7142890 YP_002400379.1 CDS yihU NC_011745.1 4526770 4527666 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase with NAD(P)-binding Rossmann-fold domain complement(4526770..4527666) Escherichia coli ED1a 7142891 YP_002400380.1 CDS yihV NC_011745.1 4527834 4528730 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sugar kinase 4527834..4528730 Escherichia coli ED1a 7142892 YP_002400381.1 CDS yihW NC_011745.1 4528764 4529549 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 4528764..4529549 Escherichia coli ED1a 7142893 YP_002400382.1 CDS yihX NC_011745.1 4529648 4530247 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; phosphatase 4529648..4530247 Escherichia coli ED1a 7142894 YP_002400383.1 CDS rbn NC_011745.1 4530241 4531113 D RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease; ribonuclease BN 4530241..4531113 Escherichia coli ED1a 7142895 YP_002400384.1 CDS dtd NC_011745.1 4531110 4531547 D hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 4531110..4531547 Escherichia coli ED1a 7141255 YP_002400385.1 CDS yiiD NC_011745.1 4531544 4532533 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acetyltransferase 4531544..4532533 Escherichia coli ED1a 7140531 YP_002400386.1 CDS ECED1_4589 NC_011745.1 4532597 4533580 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative lipase complement(4532597..4533580) Escherichia coli ED1a 7142896 YP_002400387.1 CDS ECED1_4590 NC_011745.1 4533734 4534045 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4533734..4534045 Escherichia coli ED1a 7140488 YP_002400388.1 CDS ECED1_4591 NC_011745.1 4534046 4534336 D Evidence 4 : Homologs of previously reported genes of unknown function; putative transcriptional regulator 4534046..4534336 Escherichia coli ED1a 7143550 YP_002400389.1 CDS ECED1_4592 NC_011745.1 4534695 4534973 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4534695..4534973 Escherichia coli ED1a 7143551 YP_002400390.1 CDS yiiE NC_011745.1 4535369 4535587 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 4535369..4535587 Escherichia coli ED1a 7143552 YP_002400391.1 CDS fdhE NC_011745.1 4535803 4536732 R required for the formation of active formate dehydrogenase; formate dehydrogenase accessory protein FdhE complement(4535803..4536732) Escherichia coli ED1a 7142897 YP_002400392.1 CDS fdoI NC_011745.1 4536729 4537364 R cytochrome b556(FDO) component; heme containing; formate dehydrogenase-O subunit gamma complement(4536729..4537364) Escherichia coli ED1a 7144137 YP_002400393.1 CDS fdoH NC_011745.1 4537361 4538263 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91317715, 8522521, 9852007; Product type c : carrier; formate dehydrogenase-O, Fe-S subunit complement(4537361..4538263) Escherichia coli ED1a 7144144 YP_002400394.1 CDS fdoG NC_011745.1 4538276 4541326 R Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; formate dehydrogenase-O, large subunit complement(4538276..4541326) Escherichia coli ED1a 7144143 YP_002400395.1 CDS fdhD NC_011745.1 4541520 4542353 D involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth; formate dehydrogenase accessory protein 4541520..4542353 Escherichia coli ED1a 7144142 YP_002400396.1 CDS ECED1_4600 NC_011745.1 4542441 4542995 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4542441..4542995 Escherichia coli ED1a 7144136 YP_002400397.1 CDS ECED1_4601 NC_011745.1 4543349 4544743 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative glycoporin 4543349..4544743 Escherichia coli ED1a 7143553 YP_002400398.1 CDS yiiL NC_011745.1 4544784 4545098 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15060078; Product type e : enzyme; L-rhamnose mutarotase complement(4544784..4545098) Escherichia coli ED1a 7143554 YP_002400399.1 CDS rhaD NC_011745.1 4545108 4545932 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90128204, 93374854, 8396120; Product type e : enzyme; rhamnulose-1-phosphate aldolase complement(4545108..4545932) Escherichia coli ED1a 7142898 YP_002400400.1 CDS rhaA NC_011745.1 4546117 4547376 R catalyzes the formation of L-rhamnulose from L-rhamnose; L-rhamnose isomerase complement(4546117..4547376) Escherichia coli ED1a 7141609 YP_002400401.1 CDS rhaB NC_011745.1 4547373 4548842 R catalyzes the ATP-dependent phosphorylation of rhamnulose; rhamnulokinase complement(4547373..4548842) Escherichia coli ED1a 7141607 YP_002400402.1 CDS rhaS NC_011745.1 4549130 4549966 D activates the expression of the rhaBAD operon and rhaT gene; transcriptional activator RhaS 4549130..4549966 Escherichia coli ED1a 7141608 YP_002400403.1 CDS rhaR NC_011745.1 4549950 4550888 D activates the expression of rhaRS in response to L-rhamnose; transcriptional activator RhaR 4549950..4550888 Escherichia coli ED1a 7141611 YP_002400404.1 CDS rhaT NC_011745.1 4550885 4551919 R transports L-rhamnose and L-lyxose into the cell; rhamnose-proton symporter complement(4550885..4551919) Escherichia coli ED1a 7141610 YP_002400405.1 CDS sodA NC_011745.1 4552205 4552825 D SodA; manganese binding; only present under aerobic conditions; destroys free radicals; superoxide dismutase 4552205..4552825 Escherichia coli ED1a 7141612 YP_002400406.1 CDS kdgT NC_011745.1 4553043 4553987 D transports degraded pectin products into the bacterial cell; 2-keto-3-deoxygluconate permease 4553043..4553987 Escherichia coli ED1a 7143814 YP_002400407.1 CDS yiiM NC_011745.1 4554136 4554810 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4554136..4554810 Escherichia coli ED1a 7142492 YP_002400408.1 CDS cpxA NC_011745.1 4554981 4556354 R part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors; two-component sensor protein complement(4554981..4556354) Escherichia coli ED1a 7142899 YP_002400409.1 CDS cpxR NC_011745.1 4556351 4557049 R response regulator in two-component regulatory system with CpxA; part of the envelope stress response system; DNA-binding transcriptional regulator CpxR complement(4556351..4557049) Escherichia coli ED1a 7142045 YP_002400410.1 CDS cpxP NC_011745.1 4557199 4557699 D repressor of the Cpx envelope stress response pathway which occurs via periplasmic interactions with CpxA; CpxP is degraded by DegP protease especially in the presence of misfolded substrates; periplasmic repressor CpxP 4557199..4557699 Escherichia coli ED1a 7142047 YP_002400411.1 CDS fieF NC_011745.1 4557848 4558750 D member of cation diffusion facilitator family; CDF; membrane-bound; induced by both zinc and iron, but does not induce resistance to zinc; can transport zinc(II) in a proton-dependent manner; instead this protein induces iron resistance; forms dimers; ferrous iron efflux protein F 4557848..4558750 Escherichia coli ED1a 7142046 YP_002400412.1 CDS pfkA NC_011745.1 4558931 4559893 D catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 4558931..4559893 Escherichia coli ED1a 7144178 YP_002400413.1 CDS sbp NC_011745.1 4560213 4561202 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91161616, 2002055, 3158524, 8774726, 9298646; Product type t : transporter; sulfate transporter subunit 4560213..4561202 Escherichia coli ED1a 7144067 YP_002400414.1 CDS cdh NC_011745.1 4561309 4562064 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86008270, 2995360, 3158524; Product type e : enzyme; CDP-diacylglycerol pyrophosphatase 4561309..4562064 Escherichia coli ED1a 7141376 YP_002400415.1 CDS tpiA NC_011745.1 4562119 4562886 R Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase complement(4562119..4562886) Escherichia coli ED1a 7139325 YP_002400416.1 CDS yiiQ NC_011745.1 4562994 4563593 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4562994..4563593) Escherichia coli ED1a 7140800 YP_002400417.1 CDS yiiR NC_011745.1 4563694 4564134 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4563694..4564134 Escherichia coli ED1a 7142900 YP_002400418.1 CDS yiiS NC_011745.1 4564346 4564645 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4564346..4564645 Escherichia coli ED1a 7142901 YP_002400419.1 CDS yiiT NC_011745.1 4564672 4565100 D with UspC and Usp E is involved in resistance to UV radiation; universal stress protein UspD 4564672..4565100 Escherichia coli ED1a 7142902 YP_002400420.1 CDS fpr NC_011745.1 4565105 4565851 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93194782, 94092163, 95050480, 95362685, 1400248, 2834327, 7961651, 8449868, 9149148; Product type e : enzyme; ferredoxin-NADP reductase complement(4565105..4565851) Escherichia coli ED1a 7142903 YP_002400421.1 CDS glpX NC_011745.1 4565948 4566958 R type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II complement(4565948..4566958) Escherichia coli ED1a 7142164 YP_002400422.1 CDS glpK NC_011745.1 4567129 4568637 R Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase complement(4567129..4568637) Escherichia coli ED1a 7142977 YP_002400423.1 CDS glpF NC_011745.1 4568660 4569505 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12629974, 12948772, 14646142, 15004242, 90094250, 92210584, 11039922, 11101882, 11226336, 11964478, 1372899, 2544860, 6998951; Product type t : transporter; glycerol facilitator complement(4568660..4569505) Escherichia coli ED1a 7142973 YP_002400424.1 CDS yiiU NC_011745.1 4569930 4570175 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4569930..4570175 Escherichia coli ED1a 7142971 YP_002400425.1 CDS rraA NC_011745.1 4570260 4570745 R regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA complement(4570260..4570745) Escherichia coli ED1a 7142904 YP_002400426.1 CDS menA NC_011745.1 4570838 4571764 R catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase complement(4570838..4571764) Escherichia coli ED1a 7140105 YP_002400427.1 CDS hslU NC_011745.1 4571831 4573162 R heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU complement(4571831..4573162) Escherichia coli ED1a 7142241 YP_002400428.1 CDS hslV NC_011745.1 4573172 4573702 R heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit complement(4573172..4573702) Escherichia coli ED1a 7140169 YP_002400429.1 CDS ftsN NC_011745.1 4573795 4574754 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9282742, 93285993, 8509333; Product type cp : cell process; essential cell division protein FtsN complement(4573795..4574754) Escherichia coli ED1a 7140170 YP_002400430.1 CDS cytR NC_011745.1 4574846 4575871 R negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins; DNA-binding transcriptional regulator CytR complement(4574846..4575871) Escherichia coli ED1a 7143118 YP_002400431.1 CDS priA NC_011745.1 4576027 4578225 R binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA complement(4576027..4578225) Escherichia coli ED1a 7143049 YP_002400432.1 CDS rpmE NC_011745.1 4578428 4578640 D RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 4578428..4578640 Escherichia coli ED1a 7139119 YP_002400433.1 CDS yiiX NC_011745.1 4578701 4579309 R member of the NlpC/P60 superfamily of peptidases; putative peptidoglycan peptidase complement(4578701..4579309) Escherichia coli ED1a 7141479 YP_002400434.1 CDS metJ NC_011745.1 4579369 4579824 R when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis; transcriptional repressor protein MetJ complement(4579369..4579824) Escherichia coli ED1a 7142905 YP_002400435.1 CDS metB NC_011745.1 4579963 4581123 D catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase 4579963..4581123 Escherichia coli ED1a 7142256 YP_002400436.1 CDS metL NC_011745.1 4581126 4583558 D multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartate kinase II/homoserine dehydrogenase II 4581126..4583558 Escherichia coli ED1a 7142249 YP_002400437.1 CDS tsx NC_011745.1 4583776 4584636 R Evidence 1b : Function experimentally demonstrated in the studied species; Product type m : membrane component; nucleoside channel phage T6/colicin K receptor complement(4583776..4584636) Escherichia coli ED1a 7142259 YP_002400438.1 CDS ECED1_4645 NC_011745.1 4584713 4586257 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative 5'-nucleotidase/2',3'-cyclic phosphodiesterase complement(4584713..4586257) Escherichia coli ED1a 7140838 YP_002400439.1 CDS ECED1_4646 NC_011745.1 4586204 4587469 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphoesterase 4586204..4587469 Escherichia coli ED1a 7143555 YP_002400440.1 CDS metF NC_011745.1 4587851 4588741 D MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor; 5,10-methylenetetrahydrofolate reductase 4587851..4588741 Escherichia coli ED1a 7143556 YP_002400441.1 CDS katG NC_011745.1 4589070 4591250 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90292022, 94209230, 3045098; Product type e : enzyme; catalase/hydroperoxidase HPI(I) 4589070..4591250 Escherichia coli ED1a 7142252 YP_002400442.1 CDS yijE NC_011745.1 4591344 4592249 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative permease 4591344..4592249 Escherichia coli ED1a 7142485 YP_002400443.1 CDS yijF NC_011745.1 4592276 4592893 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4592276..4592893) Escherichia coli ED1a 7142907 YP_002400444.1 CDS gldA NC_011745.1 4593169 4594272 R forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; glycerol dehydrogenase complement(4593169..4594272) Escherichia coli ED1a 7142908 YP_002400445.1 CDS fsaB NC_011745.1 4594283 4594945 R similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase complement(4594283..4594945) Escherichia coli ED1a 7143184 YP_002400446.1 CDS ptsA NC_011745.1 4594957 4597458 R Evidence 2b : Function of strongly homologous gene; PubMedId : 95291446, 7773398; Product type t : transporter; fused putative PTS enzymes: Hpr component ; enzyme I component ; enzyme IIA component complement(4594957..4597458) Escherichia coli ED1a 7142185 YP_002400447.1 CDS frwC NC_011745.1 4597767 4598846 D FrwC with FrwB, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; forms translocation channel and contains the specific substrate-binding site; putative fructose-like permease EIIC subunit 2 4597767..4598846 Escherichia coli ED1a 7141205 YP_002400448.1 CDS frwB NC_011745.1 4598861 4599181 D FrwB with FrwC, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system (PTS) permease which may phosphorylate and transport sugars into the cell; cytoplasmic protein that interacts with complex EIIA; contains the second phosphorylation site of the PTS; putative PTS system fructose-like transporter subunit EIIB 4598861..4599181 Escherichia coli ED1a 7142182 YP_002400449.1 CDS pflD NC_011745.1 4599232 4601529 D involved in production of D-lactate from glucose under microaerobic conditions; cytoplasmic protein; putative formate acetyltransferase 2 4599232..4601529 Escherichia coli ED1a 7142181 YP_002400450.1 CDS pflC NC_011745.1 4601495 4602373 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95291446, 14673546, 7773398; Product type e : enzyme; pyruvate formate lyase II activase 4601495..4602373 Escherichia coli ED1a 7144072 YP_002400451.1 CDS frwD NC_011745.1 4602375 4602716 D FrwD with FrwB, FrwC and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; phosphorylated by EIIA; FrwB homolog; putative fructose-like phosphotransferase EIIB subunit 3 4602375..4602716 Escherichia coli ED1a 7144071 YP_002400452.1 CDS yijO NC_011745.1 4602703 4603554 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(4602703..4603554) Escherichia coli ED1a 7142183 YP_002400453.1 CDS yijP NC_011745.1 4603780 4605513 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10456927; Product type pm : putative membrane component; hypothetical protein complement(4603780..4605513) Escherichia coli ED1a 7142909 YP_002400454.1 CDS ppc NC_011745.1 4605696 4608347 R catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase complement(4605696..4608347) Escherichia coli ED1a 7142910 YP_002400455.1 CDS argE NC_011745.1 4608649 4609800 R catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis; acetylornithine deacetylase complement(4608649..4609800) Escherichia coli ED1a 7139096 YP_002400456.1 CDS argC NC_011745.1 4609954 4610958 D catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase 4609954..4610958 Escherichia coli ED1a 7142613 YP_002400457.1 CDS argB NC_011745.1 4610969 4611742 D catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 4610969..4611742 Escherichia coli ED1a 7142611 YP_002400458.1 CDS argH NC_011745.1 4611803 4613176 D catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 4611803..4613176 Escherichia coli ED1a 7142610 YP_002400459.1 CDS rspA NC_011745.1 4613614 4614888 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 93341455, 94310441; Product type pe : putative enzyme; putative enolase/dehydratase 4613614..4614888 Escherichia coli ED1a 7142615 YP_002400460.1 CDS ECED1_4667 NC_011745.1 4614955 4616238 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 4614955..4616238 Escherichia coli ED1a 7140117 YP_002400461.1 CDS oxyR NC_011745.1 4616490 4617407 D Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA; DNA-binding transcriptional regulator OxyR 4616490..4617407 Escherichia coli ED1a 7139995 YP_002400462.1 CDS sthA NC_011745.1 4617390 4618790 R catalyzes the conversion of NADPH to NADH; soluble pyridine nucleotide transhydrogenase complement(4617390..4618790) Escherichia coli ED1a 7139994 YP_002400463.1 CDS ECED1_4670 NC_011745.1 4619120 4620265 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7730270; Product type e : enzyme; hippurate hydrolase 4619120..4620265 Escherichia coli ED1a 7143861 YP_002400464.1 CDS ECED1_4671 NC_011745.1 4620308 4621624 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative proton/ carboxylic acid permease 4620308..4621624 Escherichia coli ED1a 7143558 YP_002400465.1 CDS fabR NC_011745.1 4621674 4622378 D negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis; DNA-binding transcriptional repressor FabR 4621674..4622378 Escherichia coli ED1a 7143559 YP_002400466.1 CDS yijD NC_011745.1 4622378 4622737 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4622378..4622737 Escherichia coli ED1a 7144122 YP_002400467.1 CDS trmA NC_011745.1 4622777 4623877 R catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs; tRNA (uracil-5-)-methyltransferase complement(4622777..4623877) Escherichia coli ED1a 7142906 YP_002400468.2 CDS btuB NC_011745.1 4624246 4626084 D involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space; vitamin B12/cobalamin outer membrane transporter 4624246..4626084 Escherichia coli ED1a 7140768 YP_002400469.1 CDS murI NC_011745.1 4626029 4626886 D converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 4626029..4626886 Escherichia coli ED1a 7143560 YP_002400470.1 CDS murB NC_011745.1 4632408 4633436 D catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 4632408..4633436 Escherichia coli ED1a 7140741 YP_002400471.1 CDS birA NC_011745.1 4633433 4634398 D catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 4633433..4634398 Escherichia coli ED1a 7139046 YP_002400472.1 CDS coaA NC_011745.1 4634427 4635377 R catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase complement(4634427..4635377) Escherichia coli ED1a 7140457 YP_002400473.1 CDS tufB NC_011745.1 4636295 4637479 D EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 4636295..4637479 Escherichia coli ED1a 7140595 YP_002400474.1 CDS secE NC_011745.1 4637709 4638092 D forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 4637709..4638092 Escherichia coli ED1a 7140843 YP_002400475.1 CDS nusG NC_011745.1 4638094 4638639 D Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 4638094..4638639 Escherichia coli ED1a 7141388 YP_002400476.1 CDS rplK NC_011745.1 4638798 4639226 D binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 4638798..4639226 Escherichia coli ED1a 7139961 YP_002400477.1 CDS rplA NC_011745.1 4639230 4639934 D in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 4639230..4639934 Escherichia coli ED1a 7141460 YP_002400478.1 CDS rplJ NC_011745.1 4640226 4640723 D binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 4640226..4640723 Escherichia coli ED1a 7141452 YP_002400479.1 CDS rplL NC_011745.1 4640790 4641155 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90094251, 92210551, 10094780, 3309338, 377281, 4573678, 773698, 8603708, 9298646, 9515737, 9600841, 9868784; Product type s : structure; 50S ribosomal subunit protein L7/L12 4640790..4641155 Escherichia coli ED1a 7141459 YP_002400480.1 CDS rpoB NC_011745.1 4641475 4645503 D DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 4641475..4645503 Escherichia coli ED1a 7141461 YP_002400481.1 CDS rpoC NC_011745.1 4645580 4649803 D DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 4645580..4649803 Escherichia coli ED1a 7141485 YP_002400482.1 CDS thiH NC_011745.1 4650045 4651178 R in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center; thiamine biosynthesis protein ThiH complement(4650045..4651178) Escherichia coli ED1a 7141486 YP_002400483.1 CDS thiG NC_011745.1 4651175 4651945 R functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase complement(4651175..4651945) Escherichia coli ED1a 7141544 YP_002400484.1 CDS thiS NC_011745.1 4651947 4652147 R with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate; sulfur carrier protein ThiS complement(4651947..4652147) Escherichia coli ED1a 7141543 YP_002400485.1 CDS thiF NC_011745.1 4652131 4652886 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8432721, 94089392, 98298179, 10082377, 9632726; Product type e : enzyme; thiamin (thiazole moiety) biosynthesis protein complement(4652131..4652886) Escherichia coli ED1a 7141550 YP_002400486.1 CDS thiE NC_011745.1 4652879 4653514 R catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate; thiamine-phosphate pyrophosphorylase complement(4652879..4653514) Escherichia coli ED1a 7141542 YP_002400487.1 CDS thiC NC_011745.1 4653514 4655409 R required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC complement(4653514..4655409) Escherichia coli ED1a 7141541 YP_002400488.1 CDS rsd NC_011745.1 4655642 4656118 R binds specifically to the major sigma factor sigma 70; active in stationary phase; anti-RNA polymerase sigma 70 factor complement(4655642..4656118) Escherichia coli ED1a 7140769 YP_002400489.1 CDS nudC NC_011745.1 4656213 4656986 D can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates; NADH pyrophosphatase 4656213..4656986 Escherichia coli ED1a 7140108 YP_002400490.1 CDS hemE NC_011745.1 4657026 4658090 D catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 4657026..4658090 Escherichia coli ED1a 7139938 YP_002400491.1 CDS nfi NC_011745.1 4658100 4658771 D Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA; cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures; endonuclease V 4658100..4658771 Escherichia coli ED1a 7139869 YP_002400492.1 CDS yjaG NC_011745.1 4658814 4659404 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4658814..4659404 Escherichia coli ED1a 7140375 YP_002400493.1 CDS hupA NC_011745.1 4659591 4659863 D histone-like DNA-binding protein; transcriptional regulator HU subunit alpha 4659591..4659863 Escherichia coli ED1a 7142913 YP_002400494.1 CDS yjaH NC_011745.1 4659876 4660571 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4659876..4660571 Escherichia coli ED1a 7140178 YP_002400495.1 CDS zraP NC_011745.1 4660573 4661133 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98362023, 9694902; Product type pf : putative factor; zinc resistance protein complement(4660573..4661133) Escherichia coli ED1a 7142914 YP_002400496.1 CDS zraS NC_011745.1 4661230 4662606 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21140164, 89327164, 92255260, 11243806, 2666400; Product type r : regulator; sensor protein ZraS 4661230..4662606 Escherichia coli ED1a 7143281 YP_002400497.1 CDS zraR NC_011745.1 4662603 4663928 D DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein; transcriptional regulatory protein ZraR 4662603..4663928 Escherichia coli ED1a 7143197 YP_002400498.1 CDS purD NC_011745.1 4663925 4665214 R catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase complement(4663925..4665214) Escherichia coli ED1a 7142955 YP_002400499.1 CDS purH NC_011745.1 4665226 4666815 R involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase complement(4665226..4666815) Escherichia coli ED1a 7141216 YP_002400500.1 CDS yjaA NC_011745.1 4672518 4672901 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2412207; hypothetical protein 4672518..4672901 Escherichia coli ED1a 7140742 YP_002400501.1 CDS yjaB NC_011745.1 4672964 4673407 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; hypothetical protein complement(4672964..4673407) Escherichia coli ED1a 7142911 YP_002400502.1 CDS metA NC_011745.1 4673564 4674493 D catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase 4673564..4674493 Escherichia coli ED1a 7142912 YP_002400503.1 CDS aceB NC_011745.1 4674762 4676363 D Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle; malate synthase 4674762..4676363 Escherichia coli ED1a 7142248 YP_002400504.1 CDS aceA NC_011745.1 4676393 4677697 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91295197, 92112731, 92353108, 2836370, 3049537, 3060852, 3276689, 3290857, 3291954, 7826335; Product type e : enzyme; isocitrate lyase 4676393..4677697 Escherichia coli ED1a 7143637 YP_002400505.1 CDS aceK NC_011745.1 4677913 4679637 D catalyzes the phosphorylation/dephosphorylation of the enzyme isocitrate dehydrogenase on a specific serine which regulates activity; unphosphorylated IDH is fully active when cells are grown on glucose while the enzyme becomes phosphorylated and inactive in the presence of acetate or ethanol; bifunctional isocitrate dehydrogenase kinase/phosphatase protein 4677913..4679637 Escherichia coli ED1a 7143636 YP_002400506.1 CDS iclR NC_011745.1 4679654 4680478 R regulates the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase and isocitrate dehydrogenase kinase/phosphorylase; transcriptional repressor IclR complement(4679654..4680478) Escherichia coli ED1a 7143640 YP_002400507.1 CDS metH NC_011745.1 4680678 4684361 D one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity; B12-dependent methionine synthase 4680678..4684361 Escherichia coli ED1a 7140223 YP_002400508.1 CDS ECED1_4726 NC_011745.1 4684415 4684741 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4684415..4684741 Escherichia coli ED1a 7142254 YP_002400509.1 CDS ECED1_4727 NC_011745.1 4684784 4685233 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4684784..4685233 Escherichia coli ED1a 7143561 YP_002400510.1 CDS yjbB NC_011745.1 4685404 4687035 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 4685404..4687035 Escherichia coli ED1a 7143562 YP_002400511.1 CDS pepE NC_011745.1 4687125 4687814 R alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family; peptidase E complement(4687125..4687814) Escherichia coli ED1a 7142916 YP_002400512.1 CDS ECED1_4730 NC_011745.1 4688196 4689437 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7947968, 7652212; Product type e : enzyme; L-sorbose 1-phosphate reductase complement(4688196..4689437) Escherichia coli ED1a 7144061 YP_002400513.1 CDS ECED1_4731 NC_011745.1 4689477 4690331 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7947968, 7700234; Product type t : transporter; sorbose permease IID component complement(4689477..4690331) Escherichia coli ED1a 7143563 YP_002400514.1 CDS ECED1_4732 NC_011745.1 4690312 4691109 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7947968, 7700234; Product type t : transporter; sorbose permease IIC component (PTS system) complement(4690312..4691109) Escherichia coli ED1a 7143564 YP_002400515.1 CDS ECED1_4733 NC_011745.1 4691175 4691669 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7947968, 7700234, 12662934; Product type t : transporter; sorbose-specific phosphotransferase enzyme IIB component (PTS system) complement(4691175..4691669) Escherichia coli ED1a 7143565 YP_002400516.1 CDS ECED1_4734 NC_011745.1 4691669 4692076 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7947968; Product type t : transporter; sorbose-specific phosphotransferase enzyme IIA component (PTS system) complement(4691669..4692076) Escherichia coli ED1a 7143566 YP_002400517.1 CDS ECED1_4735 NC_011745.1 4692086 4692892 R Converts D-sorbitol-dphosphate to D-fructose-6-phosphate; sorbitol-6-phosphate 2-dehydrogenase complement(4692086..4692892) Escherichia coli ED1a 7143567 YP_002400518.1 CDS ECED1_4736 NC_011745.1 4692962 4693993 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7947968; Product type r : regulator; sorbitol/sorbose operon activator complement(4692962..4693993) Escherichia coli ED1a 7143568 YP_002400519.1 CDS yjbC NC_011745.1 4694257 4695129 D catalyzes the synthesis of pseudouridine from U-2604 in the 23S ribosomal RNA; 23S rRNA pseudouridine synthase F 4694257..4695129 Escherichia coli ED1a 7143569 YP_002400520.1 CDS yjbD NC_011745.1 4695130 4695402 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4695130..4695402) Escherichia coli ED1a 7142917 YP_002400521.1 CDS lysC NC_011745.1 4695655 4697004 R catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive; aspartate kinase III complement(4695655..4697004) Escherichia coli ED1a 7142918 YP_002400522.1 CDS pgi NC_011745.1 4697529 4699178 D functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 4697529..4699178 Escherichia coli ED1a 7140770 YP_002400523.1 CDS ECED1_4741 NC_011745.1 4699657 4699986 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4699657..4699986) Escherichia coli ED1a 7144074 YP_002400524.1 CDS yjbF NC_011745.1 4700105 4700743 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; putative lipoprotein 4700105..4700743 Escherichia coli ED1a 7143570 YP_002400525.1 CDS yjbG NC_011745.1 4700740 4701477 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4700740..4701477 Escherichia coli ED1a 7142919 YP_002400526.1 CDS yjbH NC_011745.1 4701477 4703573 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative porin 4701477..4703573 Escherichia coli ED1a 7142920 YP_002400527.1 CDS ECED1_4745 NC_011745.1 4703577 4703738 D Evidence 6 : Doubtful CDS; hypothetical protein 4703577..4703738 Escherichia coli ED1a 7142921 YP_002400528.1 CDS ECED1_4746 NC_011745.1 4703620 4703898 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4703620..4703898) Escherichia coli ED1a 7143571 YP_002400529.1 CDS yjbA NC_011745.1 4704113 4704523 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10986267; Product type pm : putative membrane component; phosphate-starvation-inducible protein PsiE 4704113..4704523 Escherichia coli ED1a 7143572 YP_002400530.1 CDS malG NC_011745.1 4704617 4705507 R with MalKFE is involved in the transport of maltose into the cell; maltose transporter permease complement(4704617..4705507) Escherichia coli ED1a 7142915 YP_002400531.1 CDS malF NC_011745.1 4705522 4707066 R with MalKGE is involved in maltose transport into the cell; maltose transporter membrane protein complement(4705522..4707066) Escherichia coli ED1a 7142196 YP_002400532.1 CDS malE NC_011745.1 4707220 4708410 R functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis; maltose ABC transporter periplasmic protein complement(4707220..4708410) Escherichia coli ED1a 7142195 YP_002400533.1 CDS malK NC_011745.1 4708775 4709890 D with malEFG is involved in import of maltose/maltodextrin; maltose/maltodextrin transporter ATP-binding protein 4708775..4709890 Escherichia coli ED1a 7142359 YP_002400534.1 CDS lamB NC_011745.1 4709962 4711302 D porin involved in the transport of maltose and maltodextrins; maltoporin 4709962..4711302 Escherichia coli ED1a 7142198 YP_002400535.1 CDS malM NC_011745.1 4711534 4712454 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87141162, 2434655, 6086106; Product type pt : putative transporter; maltose regulon periplasmic protein 4711534..4712454 Escherichia coli ED1a 7141868 YP_002400536.1 CDS ubiC NC_011745.1 4712633 4713130 D catalyzes the formation of 4-hydroxybenzoate from chorismate; chorismate pyruvate lyase 4712633..4713130 Escherichia coli ED1a 7142199 YP_002400537.1 CDS ubiA NC_011745.1 4713143 4714015 D catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway; 4-hydroxybenzoate octaprenyltransferase 4713143..4714015 Escherichia coli ED1a 7140858 YP_002400538.1 CDS plsB NC_011745.1 4714170 4716593 R PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase complement(4714170..4716593) Escherichia coli ED1a 7140856 YP_002400539.1 CDS dgkA NC_011745.1 4716764 4717132 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10220339, 6257698, 86278195, 88111690, 2984194, 6309817, 8071224; Product type e : enzyme; diacylglycerol kinase 4716764..4717132 Escherichia coli ED1a 7139069 YP_002400540.1 CDS lexA NC_011745.1 4717242 4717850 D Represses a number of genes involved in the response to DNA damage; LexA repressor 4717242..4717850 Escherichia coli ED1a 7143102 YP_002400541.1 CDS dinF NC_011745.1 4717869 4719248 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87165788; Product type cp : cell process; DNA-damage-inducible SOS response protein 4717869..4719248 Escherichia coli ED1a 7141883 YP_002400542.1 CDS yjbJ NC_011745.1 4719364 4719573 D unknown function; highly abundant protein in vivo; overexpressed under high NaCl concentrations; part of the sigma S regulon; non-essential; putative stress-response protein 4719364..4719573 Escherichia coli ED1a 7140489 YP_002400543.1 CDS zur NC_011745.1 4719615 4720130 R Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes znuACB; zinc uptake transcriptional repressor complement(4719615..4720130) Escherichia coli ED1a 7142922 YP_002400544.1 CDS yjbN NC_011745.1 4720286 4721281 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 22095566; Product type e : enzyme; tRNA-dihydrouridine synthase A 4720286..4721281 Escherichia coli ED1a 7143199 YP_002400545.1 CDS pspG NC_011745.1 4721205 4721657 D coordinately regulated along with pspA; PspF-dependent induction in response to secretin overexpression in Yersinia; phage shock protein G 4721205..4721657 Escherichia coli ED1a 7142923 YP_002400546.1 CDS qor NC_011745.1 4721822 4722805 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94089392, 7602590; Product type e : enzyme; quinone oxidoreductase, NADPH-dependent complement(4721822..4722805) Escherichia coli ED1a 7142924 YP_002400547.1 CDS dnaB NC_011745.1 4722888 4724303 D unwinds double stranded DNA; replicative DNA helicase 4722888..4724303 Escherichia coli ED1a 7141241 YP_002400548.1 CDS alr NC_011745.1 4724356 4725435 D converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 4724356..4725435 Escherichia coli ED1a 7140503 YP_002400549.1 CDS tyrB NC_011745.1 4725688 4726881 D catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 4725688..4726881 Escherichia coli ED1a 7143695 YP_002400550.1 CDS sucB NC_011745.1 4729840 4730994 D Evidence 2b : Function of strongly homologous gene; PubMedId : 10739245, 6376124; Product type e : enzyme; dihydrolipoamide succinyltransferase (E2 component) 4729840..4730994 Escherichia coli ED1a 7143865 YP_002400551.1 CDS ECED1_4772 NC_011745.1 4731182 4732423 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative dihydrolipoyl dehydrogenase, E3 component (lpd-like) 4731182..4732423 Escherichia coli ED1a 7143867 YP_002400552.1 CDS sucC NC_011745.1 4732445 4733614 D Evidence 1b : Function experimentally demonstrated in the studied species; Product type e : enzyme; Succinyl-CoA synthetase subunit beta (SCS-beta) 4732445..4733614 Escherichia coli ED1a 7143573 YP_002400553.1 CDS sucD NC_011745.1 4733627 4734499 D Evidence 1b : Function experimentally demonstrated in the studied species; Product type e : enzyme; Succinyl-CoA synthetase subunit alpha (SCS-alpha) 4733627..4734499 Escherichia coli ED1a 7143869 YP_002400554.1 CDS ECED1_4775 NC_011745.1 4734705 4736210 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 4734705..4736210 Escherichia coli ED1a 7143871 YP_002400555.1 CDS dctD NC_011745.1 4737283 4738641 R Evidence 2b : Function of strongly homologous gene; PubMedId : 3671068; Product type r : regulator; C4-dicarboxylate transport transcriptional regulatory protein complement(4737283..4738641) Escherichia coli ED1a 7143576 YP_002400556.1 CDS ECED1_4779 NC_011745.1 4738634 4740454 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2134335; Product type prc : putative receptor; putative C4-dicarboxylate transport sensor protein (dctB-like) complement(4738634..4740454) Escherichia coli ED1a 7143073 YP_002400557.1 CDS aphA NC_011745.1 4740731 4741444 D Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity; acid phosphatase/phosphotransferase 4740731..4741444 Escherichia coli ED1a 7143577 YP_002400558.1 CDS yjbQ NC_011745.1 4741555 4741971 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11972052; hypothetical protein 4741555..4741971 Escherichia coli ED1a 7142590 YP_002400559.1 CDS yjbR NC_011745.1 4741975 4742331 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4741975..4742331 Escherichia coli ED1a 7142925 YP_002400560.1 CDS uvrA NC_011745.1 4742366 4745188 R The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A complement(4742366..4745188) Escherichia coli ED1a 7142926 YP_002400561.1 CDS ssb NC_011745.1 4745442 4745978 D binds to single stranded DNA and PriA helcase facilitate replication restart; single-stranded DNA-binding protein 4745442..4745978 Escherichia coli ED1a 7139150 YP_002400562.1 CDS yjcB NC_011745.1 4746077 4746358 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(4746077..4746358) Escherichia coli ED1a 7143847 YP_002400563.1 CDS yjcC NC_011745.1 4746787 4748373 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative signal transduction protein 4746787..4748373 Escherichia coli ED1a 7142927 YP_002400564.1 CDS soxS NC_011745.1 4748376 4748699 R regulates genes involved in response to oxidative stress; DNA-binding transcriptional regulator SoxS complement(4748376..4748699) Escherichia coli ED1a 7142928 YP_002400565.1 CDS soxR NC_011745.1 4748785 4749249 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91210176, 91360349, 94139656, 9564045, 10207625, 12670967, 1653416, 1708380, 7673113, 8065907, 8306957, 8631739, 8969171, 9019397, 9092651, 9204707; Product type r : regulator; DNA-binding transcriptional dual regulator, Fe-S center for redox-sensing 4748785..4749249 Escherichia coli ED1a 7143822 YP_002400566.1 CDS yjcD NC_011745.1 4749796 4751145 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative permease 4749796..4751145 Escherichia coli ED1a 7141354 YP_002400567.1 CDS yjcE NC_011745.1 4751296 4752945 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 21557160, 11479290; Product type pt : putative transporter; putative cation/proton antiporter 4751296..4752945 Escherichia coli ED1a 7142929 YP_002400568.1 CDS ECED1_4792 NC_011745.1 4752981 4753865 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative LuxR family transcription regulator complement(4752981..4753865) Escherichia coli ED1a 7142930 YP_002400569.1 CDS ECED1_4793 NC_011745.1 4753969 4754379 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4753969..4754379 Escherichia coli ED1a 7143578 YP_002400570.1 CDS ECED1_4794 NC_011745.1 4754372 4755061 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4754372..4755061 Escherichia coli ED1a 7143579 YP_002400571.1 CDS actP NC_011745.1 4755100 4756749 R member of the sodium:solute symporter family; cotranscribed with the acs gene which encodes acetyl coenzyme A synthase; mutations affect acetate uptake; acetate permease complement(4755100..4756749) Escherichia coli ED1a 7143580 YP_002400572.1 CDS yjcH NC_011745.1 4756746 4757060 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14563880; Product type pm : putative membrane component; hypothetical protein complement(4756746..4757060) Escherichia coli ED1a 7143656 YP_002400573.1 CDS acs NC_011745.1 4757273 4759231 R Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA; acetyl-CoA synthetase complement(4757273..4759231) Escherichia coli ED1a 7142931 YP_002400574.1 CDS nrfA NC_011745.1 4759623 4761059 D catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552; cytochrome c552 4759623..4761059 Escherichia coli ED1a 7143655 YP_002400575.1 CDS nrfB NC_011745.1 4761104 4761670 D part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia; cytochrome c nitrite reductase pentaheme subunit 4761104..4761670 Escherichia coli ED1a 7139928 YP_002400576.1 CDS nrfC NC_011745.1 4761667 4762338 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94335626, 8057835; Product type c : carrier; formate-dependent nitrite reductase, 4Fe4S subunit 4761667..4762338 Escherichia coli ED1a 7139929 YP_002400577.1 CDS nrfD NC_011745.1 4762335 4763291 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91058381, 94335626, 8057835; Product type e : enzyme; formate-dependent nitrite reductase, membrane subunit 4762335..4763291 Escherichia coli ED1a 7139930 YP_002400578.1 CDS nrfE NC_011745.1 4763371 4765029 D with NrfF and NrfG catalyzes the insertion of heme into cytochrome c552; heme lyase subunit NrfE 4763371..4765029 Escherichia coli ED1a 7139931 YP_002400579.1 CDS nrfF NC_011745.1 4765022 4765405 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91058381, 94335626, 9593308, 8057835, 8842153; Product type f : factor; formate-dependent nitrite reductase complex subunit NrfF 4765022..4765405 Escherichia coli ED1a 7139932 YP_002400580.1 CDS nrfG NC_011745.1 4765402 4765998 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91058381, 94335626, 9593308, 8057835, 8842153; Product type f : factor; formate-dependent nitrite reductase complex subunit NrfG 4765402..4765998 Escherichia coli ED1a 7139933 YP_002400581.1 CDS gltP NC_011745.1 4766341 4767654 D carrier protein part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system; glutamate/aspartate:proton symporter 4766341..4767654 Escherichia coli ED1a 7139934 YP_002400582.1 CDS yjcO NC_011745.1 4768369 4769058 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4768369..4769058) Escherichia coli ED1a 7142985 YP_002400583.1 CDS ECED1_4807 NC_011745.1 4769169 4769873 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATP-binding protein YddO complement(4769169..4769873) Escherichia coli ED1a 7142932 YP_002400584.1 CDS ECED1_4808 NC_011745.1 4769860 4770756 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative dipeptide/oligopeptide/nickel transport system, ATPase complement(4769860..4770756) Escherichia coli ED1a 7143581 YP_002400585.1 CDS ECED1_4809 NC_011745.1 4770689 4771522 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative dipeptide/nickel transporter, Inner membrane permease subunit (yddQ) complement(4770689..4771522) Escherichia coli ED1a 7143582 YP_002400586.1 CDS ECED1_4810 NC_011745.1 4771522 4772664 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative dipeptide/nickel transporter, Inner membrane permease subunit (yddR) complement(4771522..4772664) Escherichia coli ED1a 7143583 YP_002400587.1 CDS ECED1_4811 NC_011745.1 4772671 4774239 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC-type dipeptide transport system, periplasmic component complement(4772671..4774239) Escherichia coli ED1a 7143584 YP_002400588.1 CDS fdhF NC_011745.1 4774614 4776761 R Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; formate dehydrogenase-H, selenopolypeptide subunit complement(4774614..4776761) Escherichia coli ED1a 7143585 YP_002400589.1 CDS yjcP NC_011745.1 4776959 4778425 R part of a multidrug efflux system involved in resistance to acriflavin, puromycin, erytjhromycin and tetraphenylarsonium chloride; member of the outer membrane factor (OMF) family; putative outer membrane efflux protein MdtP complement(4776959..4778425) Escherichia coli ED1a 7144138 YP_002400590.1 CDS yjcQ NC_011745.1 4778422 4780473 R possibly part of a tripartite efflux system composed of MdtN, MdtO and MdtP which could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug efflux system protein MdtO complement(4778422..4780473) Escherichia coli ED1a 7142933 YP_002400591.1 CDS yjcR NC_011745.1 4780473 4781504 R with MdtO and MdtP is involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug resistance protein MdtN complement(4780473..4781504) Escherichia coli ED1a 7142934 YP_002400592.1 CDS yjcS NC_011745.1 4782044 4784005 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1587481; Product type pe : putative enzyme; putative alkyl sulfatase complement(4782044..4784005) Escherichia coli ED1a 7142935 YP_002400593.1 CDS alsK NC_011745.1 4784266 4785195 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20026827, 9401019; Product type e : enzyme; D-allose kinase complement(4784266..4785195) Escherichia coli ED1a 7142936 YP_002400594.1 CDS alsE NC_011745.1 4785179 4785874 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20026827, 9401019; Product type e : enzyme; allulose-6-phosphate 3-epimerase complement(4785179..4785874) Escherichia coli ED1a 7143700 YP_002400595.1 CDS alsC NC_011745.1 4785885 4786865 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20026827, 9401019; Product type t : transporter; D-allose transporter subunit complement(4785885..4786865) Escherichia coli ED1a 7143699 YP_002400596.1 CDS alsA NC_011745.1 4786844 4788376 R with AlsBC acts to import allose into the cell; AlsA contain 2 ATP-binding domains; D-allose transporter ATP-binding protein complement(4786844..4788376) Escherichia coli ED1a 7143698 YP_002400597.1 CDS alsB NC_011745.1 4788504 4789439 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20026827, 9401019, 10064713, 8576032; Product type t : transporter; D-allose transporter subunit complement(4788504..4789439) Escherichia coli ED1a 7143696 YP_002400598.1 CDS rpiR NC_011745.1 4789498 4790388 R involved in rpiB and als operon repression; DNA-binding transcriptional repressor RpiR complement(4789498..4790388) Escherichia coli ED1a 7143697 YP_002400599.1 CDS rpiB NC_011745.1 4790747 4791196 D catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity; ribose-5-phosphate isomerase B 4790747..4791196 Escherichia coli ED1a 7141451 YP_002400600.1 CDS yjdP NC_011745.1 4791265 4791594 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4791265..4791594 Escherichia coli ED1a 7141450 YP_002400601.1 CDS phnP NC_011745.1 4791622 4792380 R required for the use of phosphonates and phosphite as phosphorus sources; carbon-phosphorus lyase complex accessory protein complement(4791622..4792380) Escherichia coli ED1a 7142946 YP_002400602.1 CDS phnO NC_011745.1 4792382 4792816 R PhnO in Salmonella enterica catalyzes the acetylation of a range of aminoalkylphosphonic acids; part of the biochemical pathway that enables the cell to use phosphonates as a phosphorus source; Escherichia coli uses a different mechanism of phosphonate catabolism where PhnO is not essential and seems to play a regulatory role; aminoalkylphosphonic acid N-acetyltransferase complement(4792382..4792816) Escherichia coli ED1a 7144101 YP_002400603.1 CDS phnN NC_011745.1 4792803 4793360 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12700258, 91100346, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; ribose 1,5-bisphosphokinase complement(4792803..4793360) Escherichia coli ED1a 7144100 YP_002400604.1 CDS phnM NC_011745.1 4793360 4794496 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91100346, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit complement(4793360..4794496) Escherichia coli ED1a 7144099 YP_002400605.1 CDS phnL NC_011745.1 4794493 4795173 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit complement(4794493..4795173) Escherichia coli ED1a 7144098 YP_002400606.1 CDS phnK NC_011745.1 4795284 4796042 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; phosphonate C-P lyase system protein PhnK complement(4795284..4796042) Escherichia coli ED1a 7144097 YP_002400607.1 CDS phnJ NC_011745.1 4796039 4796884 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit complement(4796039..4796884) Escherichia coli ED1a 7144096 YP_002400608.1 CDS phnI NC_011745.1 4796877 4797941 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit complement(4796877..4797941) Escherichia coli ED1a 7144095 YP_002400609.1 CDS phnH NC_011745.1 4797941 4798525 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit complement(4797941..4798525) Escherichia coli ED1a 7144094 YP_002400610.1 CDS phnG NC_011745.1 4798522 4798974 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit complement(4798522..4798974) Escherichia coli ED1a 7144093 YP_002400611.1 CDS phnF NC_011745.1 4798975 4799700 R may be involved in phosphonate uptake and biodegradation; phosphonate metabolism transcriptional regulator PhnF complement(4798975..4799700) Escherichia coli ED1a 7144092 YP_002400612.1 CDS phnE NC_011745.1 4799721 4800563 R Evidence 2b : Function of strongly homologous gene; Product type t : transporter; phosphonates transport system permease complement(4799721..4800563) Escherichia coli ED1a 7144091 YP_002400613.1 CDS phnD NC_011745.1 4800606 4801622 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type t : transporter; phosphonate/organophosphate ester ABC transporter periplasmic binding protein complement(4800606..4801622) Escherichia coli ED1a 7144090 YP_002400614.1 CDS phnC NC_011745.1 4801647 4802435 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type t : transporter; phosphonate/organophosphate ester transporter subunit complement(4801647..4802435) Escherichia coli ED1a 7144089 YP_002400615.1 CDS phnB NC_011745.1 4802568 4803011 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 93328121, 9650256, 2155230; hypothetical protein complement(4802568..4803011) Escherichia coli ED1a 7144088 YP_002400616.1 CDS ECED1_4842 NC_011745.1 4803171 4803653 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9650256, 2155230; Product type pt : putative transporter; putative alkylphosphonate uptake protein in phosphonate metabolism complement(4803171..4803653) Escherichia coli ED1a 7144087 YP_002400617.1 CDS yjdA NC_011745.1 4803908 4806136 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4803908..4806136 Escherichia coli ED1a 7143586 YP_002400618.1 CDS yjcZ NC_011745.1 4806133 4807011 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4806133..4807011 Escherichia coli ED1a 7142938 YP_002400619.1 CDS proP NC_011745.1 4807275 4808777 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10049386, 12525168, 92165733, 93132799, 9871325, 99376621, 8421314; Product type t : transporter; proline/glycine betaine transporter 4807275..4808777 Escherichia coli ED1a 7142937 YP_002400620.1 CDS basS NC_011745.1 4808954 4810045 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94110256, 8282725; Product type r : regulator; sensor protein BasS/PmrB complement(4808954..4810045) Escherichia coli ED1a 7139130 YP_002400621.1 CDS basR NC_011745.1 4810055 4810723 R response regulator in two-component regulatory system with BasS; DNA-binding transcriptional regulator BasR complement(4810055..4810723) Escherichia coli ED1a 7140431 YP_002400622.1 CDS eptA NC_011745.1 4810720 4812363 R with ZipA and an unidentified 24 kDa protein forms a complex involved in cell division; putative cell division protein complement(4810720..4812363) Escherichia coli ED1a 7140430 YP_002400623.1 CDS adiC NC_011745.1 4812467 4813804 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12867448; Product type t : transporter; arginine:agmatin antiporter complement(4812467..4813804) Escherichia coli ED1a 7139807 YP_002400624.1 CDS adiY NC_011745.1 4813941 4814702 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : c; Product type r : regulator; DNA-binding transcriptional activator complement(4813941..4814702) Escherichia coli ED1a 7143663 YP_002400625.1 CDS adiA NC_011745.1 4815038 4817308 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93186686, 2830169, 4204273, 8383109; Product type e : enzyme; biodegradative arginine decarboxylase complement(4815038..4817308) Escherichia coli ED1a 7143664 YP_002400626.1 CDS melR NC_011745.1 4817504 4818412 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90060832, 9108148, 1445207, 2684786, 2830169; Product type r : regulator; DNA-binding transcriptional regulator MelR complement(4817504..4818412) Escherichia coli ED1a 7143662 YP_002400627.1 CDS melA NC_011745.1 4818695 4820050 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87174747, 88162811, 90248411, 2831880, 3031590, 6329200; Product type e : enzyme; alpha-galactosidase, NAD(P)-binding 4818695..4820050 Escherichia coli ED1a 7142240 YP_002400628.1 CDS yjdF NC_011745.1 4820047 4820697 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(4820047..4820697) Escherichia coli ED1a 7142239 YP_002400629.1 CDS fumB NC_011745.1 4820820 4822466 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86142617, 88193096, 89255123, 2656658; Product type e : enzyme; anaerobic class I fumarate hydratase complement(4820820..4822466) Escherichia coli ED1a 7142940 YP_002400630.1 CDS dcuB NC_011745.1 4822544 4823884 R functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters; anaerobic C4-dicarboxylate transporter complement(4822544..4823884) Escherichia coli ED1a 7143132 YP_002400631.1 CDS dcuR NC_011745.1 4824455 4825174 R response regulator in two-component regulatory system with DcuS; phosphorylated DcuR activates transcription of genes involved in anaerobic fumarate respiration; DNA-binding transcriptional activator DcuR complement(4824455..4825174) Escherichia coli ED1a 7143075 YP_002400632.1 CDS dcuS NC_011745.1 4825171 4826802 R C4-dicarboxylate-sensing histidine kinase; part of two-component regulatory system with DcuR; regulates anaerobic fumarate respiration; sensory histidine kinase DcuS complement(4825171..4826802) Escherichia coli ED1a 7143077 YP_002400633.1 CDS yjdI NC_011745.1 4826983 4827213 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4826983..4827213 Escherichia coli ED1a 7143078 YP_002400634.1 CDS yjdJ NC_011745.1 4827225 4827497 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acyl-CoA N-acyltransferase domain-containing acyltransferase 4827225..4827497 Escherichia coli ED1a 7142941 YP_002400635.1 CDS yjdK NC_011745.1 4827725 4828021 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4827725..4828021 Escherichia coli ED1a 7142942 YP_002400636.1 CDS yjdO NC_011745.1 4828049 4828222 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4828049..4828222 Escherichia coli ED1a 7142943 YP_002400637.1 CDS lysU NC_011745.1 4828341 4829858 R class II; inducible; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; induced by high temperature, anaerobiosis, and low pH; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase complement(4828341..4829858) Escherichia coli ED1a 7142945 YP_002400638.1 CDS yjdL NC_011745.1 4830095 4831552 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter complement(4830095..4831552) Escherichia coli ED1a 7141936 YP_002400639.1 CDS cadA NC_011745.1 4831611 4833758 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92105022, 92210511, 1370290, 1556085, 4204273; Product type e : enzyme; lysine decarboxylase 1 complement(4831611..4833758) Escherichia coli ED1a 7142944 YP_002400640.1 CDS cadB NC_011745.1 4833838 4835172 R antiporter protein responsible for lysine import and cadaverine export; member of the lysine-dependent acid resistance system 4 (AR4); inner membrane protein; lysine/cadaverine antiporter complement(4833838..4835172) Escherichia coli ED1a 7140477 YP_002400641.1 CDS cadC NC_011745.1 4835538 4837076 R regulates the cadBA operon; DNA-binding transcriptional activator CadC complement(4835538..4837076) Escherichia coli ED1a 7140478 YP_002400642.1 CDS ECED1_4870 NC_011745.1 4837363 4837581 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4837363..4837581 Escherichia coli ED1a 7140479 YP_002400643.1 CDS ECED1_4872 NC_011745.1 4838491 4838733 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4838491..4838733) Escherichia coli ED1a 7143588 YP_002400644.1 CDS yeeW NC_011745.1 4838700 4839188 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4838700..4839188) Escherichia coli ED1a 7143589 YP_002400645.1 CDS yeeV NC_011745.1 4839185 4839559 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594833; Product type h : extrachromosomal origin; toxin of the YeeV-YeeU toxin-antitoxin system; CP4-44 prophage complement(4839185..4839559) Escherichia coli ED1a 7139406 YP_002400646.1 CDS yeeU NC_011745.1 4839649 4840017 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594833; Product type h : extrachromosomal origin; CP4-44 prophage YeeV-YeeU toxin-antitoxin system toxin complement(4839649..4840017) Escherichia coli ED1a 7139402 YP_002400647.1 CDS ECED1_4876 NC_011745.1 4840067 4840180 R Evidence 6 : Doubtful CDS; hypothetical protein complement(4840067..4840180) Escherichia coli ED1a 7139397 YP_002400648.1 CDS yeeT NC_011745.1 4840180 4840401 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(4840180..4840401) Escherichia coli ED1a 7143590 YP_002400649.1 CDS yeeS NC_011745.1 4840464 4840910 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11053371; Product type pf : putative factor; putative DNA repair protein; CP4-44 prophage complement(4840464..4840910) Escherichia coli ED1a 7139392 YP_002400650.1 CDS ECED1_4879 NC_011745.1 4840956 4841294 R Evidence 6 : Doubtful CDS; hypothetical protein complement(4840956..4841294) Escherichia coli ED1a 7139387 YP_002400651.1 CDS ECED1_4881 NC_011745.1 4841495 4842313 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4841495..4842313) Escherichia coli ED1a 7143592 YP_002400652.1 CDS ECED1_4882 NC_011745.1 4842413 4842646 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4842413..4842646) Escherichia coli ED1a 7143593 YP_002400653.1 CDS ECED1_4883 NC_011745.1 4842725 4843180 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4842725..4843180) Escherichia coli ED1a 7143594 YP_002400654.1 CDS ECED1_4884 NC_011745.1 4843256 4845778 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(4843256..4845778) Escherichia coli ED1a 7143595 YP_002400655.1 CDS ECED1_4886 NC_011745.1 4846976 4847659 R Evidence 7 : Gene remnant; hypothetical protein complement(4846976..4847659) Escherichia coli ED1a 7143597 YP_002400656.1 CDS ECED1_4887 NC_011745.1 4847548 4847823 D Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF3 (fragment), ISEc8, IS66 family 4847548..4847823 Escherichia coli ED1a 7143598 YP_002400657.1 CDS ECED1_4888 NC_011745.1 4848031 4848192 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4848031..4848192 Escherichia coli ED1a 7143599 YP_002400658.1 CDS ECED1_4889 NC_011745.1 4848285 4849517 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative reverse transcriptase 4848285..4849517 Escherichia coli ED1a 7143600 YP_002400659.1 CDS ECED1_4891 NC_011745.1 4850007 4850432 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative transposase OrfA from plasmid origin 4850007..4850432 Escherichia coli ED1a 7143602 YP_002400660.1 CDS ECED1_4892 NC_011745.1 4850429 4850779 D Evidence 4 : Homologs of previously reported genes of unknown function; putative transposase ORF2, IS66 family 4850429..4850779 Escherichia coli ED1a 7143603 YP_002400661.1 CDS ECED1_4893 NC_011745.1 4850810 4852453 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4850810..4852453 Escherichia coli ED1a 7143604 YP_002400662.1 CDS ECED1_4894 NC_011745.1 4852600 4852824 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4852600..4852824) Escherichia coli ED1a 7143605 YP_002400663.1 CDS ECED1_4895 NC_011745.1 4853058 4855148 R IrgA-homologue adhesin (Iha); TonB-dependent; acts as a specific receptor of enterobactin; fur-regulated; urovirulence factor; bifunctional enterobactin receptor/adhesin protein complement(4853058..4855148) Escherichia coli ED1a 7143606 YP_002400664.1 CDS ECED1_4899 NC_011745.1 4857556 4857720 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4857556..4857720 Escherichia coli ED1a 7143610 YP_002400665.1 CDS ECED1_4900 NC_011745.1 4858519 4858677 R Evidence 6 : Doubtful CDS; hypothetical protein complement(4858519..4858677) Escherichia coli ED1a 7143611 YP_002400666.1 CDS iutA NC_011745.1 4858683 4860962 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 4313071, 6456229, 7044820, 7042696, 6749806; Product type rc : receptor; Ferric aerobactin receptor complement(4858683..4860962) Escherichia coli ED1a 7143612 YP_002400667.1 CDS iucD NC_011745.1 4860884 4862221 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3275632, 10064136; Product type e : enzyme; L-lysine 6-monooxygenase complement(4860884..4862221) Escherichia coli ED1a 7142475 YP_002400668.1 CDS iucC NC_011745.1 4862218 4863960 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3087960; Product type e : enzyme; Aerobactin siderophore biosynthesis protein complement(4862218..4863960) Escherichia coli ED1a 7142474 YP_002400669.1 CDS iucB NC_011745.1 4863960 4864907 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3087960; Product type e : enzyme; aerobactin siderophore biosynthesis N(6)-hydroxylysine acetylase complement(4863960..4864907) Escherichia coli ED1a 7142473 YP_002400670.1 CDS iucA NC_011745.1 4864908 4866698 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3087960; Product type e : enzyme; aerobactin siderophore biosynthesis protein complement(4864908..4866698) Escherichia coli ED1a 7142472 YP_002400671.1 CDS ECED1_4907 NC_011745.1 4867561 4867911 R Evidence 4 : Homologs of previously reported genes of unknown function; putative transposase ORF2, IS66 family complement(4867561..4867911) Escherichia coli ED1a 7143796 YP_002400672.1 CDS ECED1_4908 NC_011745.1 4867908 4868333 R Evidence 4 : Homologs of previously reported genes of unknown function; putative transposase complement(4867908..4868333) Escherichia coli ED1a 7143613 YP_002400673.1 CDS ECED1_4909 NC_011745.1 4868361 4868564 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4868361..4868564 Escherichia coli ED1a 7143614 YP_002400674.1 CDS ECED1_4910 NC_011745.1 4868539 4868802 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4868539..4868802 Escherichia coli ED1a 7143615 YP_002400675.1 CDS ECED1_4911 NC_011745.1 4868995 4869912 D catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid; N-acetylneuraminate lyase 4868995..4869912 Escherichia coli ED1a 7143616 YP_002400676.1 CDS nanK NC_011745.1 4869946 4870821 D catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein; N-acetylmannosamine kinase 4869946..4870821 Escherichia coli ED1a 7143617 YP_002400677.1 CDS ECED1_4913 NC_011745.1 4870834 4872342 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; putative sialic acid transporter 4870834..4872342 Escherichia coli ED1a 7140346 YP_002400678.1 CDS ECED1_4914 NC_011745.1 4872346 4873176 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4872346..4873176 Escherichia coli ED1a 7143618 YP_002400679.1 CDS ECED1_4915 NC_011745.1 4873192 4873932 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15743943; Product type pm : putative membrane component; putative N-acetylneuraminic acid outer membrane channel protein nanC 4873192..4873932 Escherichia coli ED1a 7143619 YP_002400680.1 CDS ECED1_4916 NC_011745.1 4873936 4875054 D Evidence 4 : Homologs of previously reported genes of unknown function; N-acetylneuraminic acid mutarotase 4873936..4875054 Escherichia coli ED1a 7143620 YP_002400681.1 CDS ECED1_4917 NC_011745.1 4875104 4876039 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase 4875104..4876039 Escherichia coli ED1a 7143621 YP_002400682.1 CDS nanR NC_011745.1 4876075 4876809 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type r : regulator; Transcriptional regulator complement(4876075..4876809) Escherichia coli ED1a 7143622 YP_002400683.1 CDS ECED1_4919 NC_011745.1 4876906 4877895 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4876906..4877895 Escherichia coli ED1a 7140348 YP_002400684.1 CDS int NC_011745.1 4879739 4881001 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Prophage integrase complement(4879739..4881001) Escherichia coli ED1a 7143624 YP_002400685.1 CDS yjdC NC_011745.1 4881381 4881956 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1370290; Product type pr : putative regulator; putative transcriptional regulator complement(4881381..4881956) Escherichia coli ED1a 7140604 YP_002400686.1 CDS dipZ NC_011745.1 4881993 4883690 R two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm; thiol:disulfide interchange protein complement(4881993..4883690) Escherichia coli ED1a 7142939 YP_002400687.1 CDS cutA NC_011745.1 4883666 4884004 R copper binding protein required for copper tolerance; involved in resistance toward heavy metals; divalent-cation tolerance protein CutA complement(4883666..4884004) Escherichia coli ED1a 7140492 YP_002400688.1 CDS dcuA NC_011745.1 4884120 4885421 R functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB; anaerobic C4-dicarboxylate transporter complement(4884120..4885421) Escherichia coli ED1a 7142089 YP_002400689.1 CDS aspA NC_011745.1 4885539 4886975 R catalyzes the formation of fumarate from aspartate; aspartate ammonia-lyase complement(4885539..4886975) Escherichia coli ED1a 7143074 YP_002400690.1 CDS fxsA NC_011745.1 4887312 4887788 D F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein; FxsA protein 4887312..4887788 Escherichia coli ED1a 7142649 YP_002400691.1 CDS yjeH NC_011745.1 4887804 4889060 R uncharacterized member of the APC superfamily of amino acid transporters; unknown function; inner membrane protein YjeH complement(4887804..4889060) Escherichia coli ED1a 7143136 YP_002400692.1 CDS groES NC_011745.1 4889336 4889629 D 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 4889336..4889629 Escherichia coli ED1a 7142949 YP_002400693.1 CDS groEL NC_011745.1 4889673 4891319 D 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL 4889673..4891319 Escherichia coli ED1a 7143022 YP_002400694.1 CDS yjeI NC_011745.1 4891457 4891810 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4891457..4891810 Escherichia coli ED1a 7143021 YP_002400695.1 CDS yjeJ NC_011745.1 4891860 4892729 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4891860..4892729) Escherichia coli ED1a 7142950 YP_002400696.1 CDS yjeK NC_011745.1 4892964 4893992 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2019591, 10629195; Product type pe : putative enzyme; putative lysine aminomutase complement(4892964..4893992) Escherichia coli ED1a 7142951 YP_002400697.1 CDS efp NC_011745.1 4894034 4894600 D Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 4894034..4894600 Escherichia coli ED1a 7142953 YP_002400698.1 CDS ecnB NC_011745.1 4894888 4895034 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98344100, 9677290; Product type lp : lipoprotein; entericidin B membrane lipoprotein 4894888..4895034 Escherichia coli ED1a 7139777 YP_002400699.1 CDS sugE NC_011745.1 4895210 4895527 D member of the SMR family of proton-dependent drug efflux transporters; quaternary ammonium compound efflux pump; confers resistance to cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations; quaternary ammonium compound-resistance protein SugE 4895210..4895527 Escherichia coli ED1a 7139768 YP_002400700.1 CDS blc NC_011745.1 4895524 4896057 R lipocalin; globomycin-sensitive outer membrane lipoprotein; outer membrane lipoprotein Blc complement(4895524..4896057) Escherichia coli ED1a 7141497 YP_002400701.1 CDS ampC NC_011745.1 4896146 4897279 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92212899, 97464439, 99421326, 10595535, 6795623, 7041115, 9819201; Product type e : enzyme; beta-lactamase complement(4896146..4897279) Escherichia coli ED1a 7140459 YP_002400702.1 CDS frdD NC_011745.1 4897342 4897701 R in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane; fumarate reductase subunit D complement(4897342..4897701) Escherichia coli ED1a 7143706 YP_002400703.1 CDS frdC NC_011745.1 4897712 4898107 R part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase subunit C complement(4897712..4898107) Escherichia coli ED1a 7142169 YP_002400704.1 CDS frdB NC_011745.1 4898118 4898852 R part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase iron-sulfur subunit complement(4898118..4898852) Escherichia coli ED1a 7142168 YP_002400705.1 CDS frdA NC_011745.1 4898845 4900653 R part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase flavoprotein subunit complement(4898845..4900653) Escherichia coli ED1a 7142167 YP_002400706.1 CDS poxA NC_011745.1 4900978 4901955 D lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase 4900978..4901955 Escherichia coli ED1a 7142166 YP_002400707.1 CDS yjeM NC_011745.1 4902132 4903628 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 4902132..4903628 Escherichia coli ED1a 7139093 YP_002400708.1 CDS yjeP NC_011745.1 4903827 4907150 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; hypothetical protein complement(4903827..4907150) Escherichia coli ED1a 7138875 YP_002400709.1 CDS psd NC_011745.1 4907172 4908140 R catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine; phosphatidylserine decarboxylase complement(4907172..4908140) Escherichia coli ED1a 7139548 YP_002400710.1 CDS rsgA NC_011745.1 4908237 4909289 R EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase complement(4908237..4909289) Escherichia coli ED1a 7141188 YP_002400711.1 CDS orn NC_011745.1 4909384 4909929 D 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 4909384..4909929 Escherichia coli ED1a 7140113 YP_002400712.1 CDS yjeS NC_011745.1 4910708 4911847 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative Fe-S electron transport protein complement(4910708..4911847) Escherichia coli ED1a 7140599 YP_002400713.1 CDS yjeF NC_011745.1 4911825 4913393 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 4911825..4913393 Escherichia coli ED1a 7139549 YP_002400714.1 CDS yjeE NC_011745.1 4913365 4913826 D possibly involved in cell wall synthesis; putative ATPase 4913365..4913826 Escherichia coli ED1a 7142948 YP_002400715.1 CDS amiB NC_011745.1 4913830 4915176 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21348478, 87242501, 1594459, 7511774; Product type e : enzyme; N-acetylmuramoyl-l-alanine amidase II 4913830..4915176 Escherichia coli ED1a 7142947 YP_002400716.1 CDS mutL NC_011745.1 4915186 4917033 D This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 4915186..4917033 Escherichia coli ED1a 7143703 YP_002400717.1 CDS miaA NC_011745.1 4917026 4917976 D IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 4917026..4917976 Escherichia coli ED1a 7139055 YP_002400718.1 CDS hfq NC_011745.1 4918062 4918370 D Stimulates the elongation of poly(A) tails; RNA-binding protein Hfq 4918062..4918370 Escherichia coli ED1a 7138979 YP_002400719.1 CDS hflX NC_011745.1 4918446 4919726 D involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein; putative GTPase HflX 4918446..4919726 Escherichia coli ED1a 7139882 YP_002400720.1 CDS hflK NC_011745.1 4919812 4921071 D with HflC inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflK 4919812..4921071 Escherichia coli ED1a 7139881 YP_002400721.1 CDS hflC NC_011745.1 4921074 4922078 D with HflK inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflC 4921074..4922078 Escherichia coli ED1a 7139880 YP_002400722.1 CDS yjeT NC_011745.1 4922160 4922357 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4922160..4922357 Escherichia coli ED1a 7139878 YP_002400723.1 CDS purA NC_011745.1 4922461 4923759 D catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 4922461..4923759 Escherichia coli ED1a 7139550 YP_002400724.1 CDS nsrR NC_011745.1 4923964 4924389 D negatively regulates the transcription of genes upregulated by nitrosative stress; transcriptional repressor NsrR 4923964..4924389 Escherichia coli ED1a 7141213 YP_002400725.1 CDS rnr NC_011745.1 4924428 4926869 D 3'-5'exoribonuclease that acts nonspecifically on poly(A), poly(U) and ribosomal RNAs; exoribonuclease R 4924428..4926869 Escherichia coli ED1a 7139935 YP_002400726.1 CDS rlmB NC_011745.1 4926960 4927691 D Specifically methylates the ribose of guanosine 2251 in 23S rRNA; 23S rRNA (guanosine-2'-O-)-methyltransferase 4926960..4927691 Escherichia coli ED1a 7141442 YP_002400727.1 CDS yjfI NC_011745.1 4927818 4928219 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4927818..4928219 Escherichia coli ED1a 7141421 YP_002400728.1 CDS yjfJ NC_011745.1 4928238 4928936 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator effector protein 4928238..4928936 Escherichia coli ED1a 7139553 YP_002400729.1 CDS yjfK NC_011745.1 4928986 4929645 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4928986..4929645 Escherichia coli ED1a 7139554 YP_002400730.1 CDS yjfL NC_011745.1 4929663 4930061 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4929663..4930061 Escherichia coli ED1a 7139555 YP_002400731.1 CDS yjfM NC_011745.1 4930071 4930709 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4930071..4930709 Escherichia coli ED1a 7139556 YP_002400732.1 CDS aidB NC_011745.1 4931959 4933584 D catalyzes the formation of 3-methylcrotonyl-CoA from isovaleryl-CoA; isovaleryl CoA dehydrogenase 4931959..4933584 Escherichia coli ED1a 7139552 YP_002400733.1 CDS yjfN NC_011745.1 4933701 4933976 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4933701..4933976) Escherichia coli ED1a 7143683 YP_002400734.1 CDS yjfO NC_011745.1 4934125 4934454 R in Escherichia coli, mutation of this gene affects biofilm maturation, stress response, and motility; putative biofilm stress and motility protein A complement(4934125..4934454) Escherichia coli ED1a 7139558 YP_002400735.1 CDS yjfP NC_011745.1 4934636 4935385 D YjfP; esterase activity towards palmitoyl-CoA and pNP-butyrate in vitro; unknown function and substrate in vivo; esterase 4934636..4935385 Escherichia coli ED1a 7139559 YP_002400736.1 CDS ulaR NC_011745.1 4935382 4936137 R negative regulator of ulaG and ulaABCDEF; transcriptional repressor UlaR complement(4935382..4936137) Escherichia coli ED1a 7139560 YP_002400737.1 CDS ulaG NC_011745.1 4936245 4937309 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12644495, 15808744; Product type pe : putative enzyme; putative L-ascorbate 6-phosphate lactonase complement(4936245..4937309) Escherichia coli ED1a 7138893 YP_002400738.1 CDS ulaA NC_011745.1 4937664 4939061 D membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 4937664..4939061 Escherichia coli ED1a 7138892 YP_002400739.1 CDS ulaB NC_011745.1 4939077 4939382 D involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system L-ascorbate-specific transporter subunit IIB 4939077..4939382 Escherichia coli ED1a 7138886 YP_002400740.1 CDS ulaC NC_011745.1 4939392 4939856 D involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system L-ascorbate-specific transporter subunit IIA 4939392..4939856 Escherichia coli ED1a 7138887 YP_002400741.1 CDS ulaD NC_011745.1 4939870 4940520 D catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase 4939870..4940520 Escherichia coli ED1a 7138888 YP_002400742.1 CDS ECED1_4984 NC_011745.1 4940792 4941640 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9987116; hypothetical protein complement(4940792..4941640) Escherichia coli ED1a 7138889 YP_002400743.1 CDS yeeW NC_011745.1 4941919 4942422 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4941919..4942422) Escherichia coli ED1a 7139407 YP_002400744.1 CDS yeeV NC_011745.1 4942419 4942898 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594833; Product type f : factor; toxin of the YeeV-YeeU toxin-antitoxin system complement(4942419..4942898) Escherichia coli ED1a 7139408 YP_002400745.1 CDS yeeU NC_011745.1 4942843 4943217 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594833; Product type h : extrachromosomal origin; CP4-44 prophage YeeV-YeeU toxin-antitoxin system toxin complement(4942843..4943217) Escherichia coli ED1a 7139403 YP_002400746.1 CDS yeeT NC_011745.1 4943297 4943518 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(4943297..4943518) Escherichia coli ED1a 7139398 YP_002400747.1 CDS yeeS NC_011745.1 4943605 4944096 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11053371; Product type pf : putative factor; putative DNA repair protein; CP4-44 prophage complement(4943605..4944096) Escherichia coli ED1a 7139393 YP_002400748.1 CDS ECED1_4991 NC_011745.1 4944097 4944435 R Evidence 6 : Doubtful CDS; hypothetical protein complement(4944097..4944435) Escherichia coli ED1a 7139388 YP_002400749.1 CDS ECED1_4993 NC_011745.1 4944636 4945457 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4944636..4945457) Escherichia coli ED1a 7143627 YP_002400750.1 CDS ECED1_4994 NC_011745.1 4945561 4945749 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4945561..4945749 Escherichia coli ED1a 7143628 YP_002400751.1 CDS ECED1_4996 NC_011745.1 4945870 4946325 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4945870..4946325) Escherichia coli ED1a 7142358 YP_002400752.1 CDS ECED1_4998 NC_011745.1 4947970 4948242 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4947970..4948242 Escherichia coli ED1a 7142361 YP_002400753.1 CDS ECED1_4999 NC_011745.1 4948314 4948547 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(4948314..4948547) Escherichia coli ED1a 7142362 YP_002400754.1 CDS ECED1_5000 NC_011745.1 4948514 4948729 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(4948514..4948729) Escherichia coli ED1a 7142363 YP_002400755.1 CDS nanE NC_011745.1 4948790 4949479 R Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase complement(4948790..4949479) Escherichia coli ED1a 7142364 YP_002400756.1 CDS ptsG NC_011745.1 4949479 4951080 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1508157; Product type e : enzyme; PTS system glucose-specific enzyme II, ABC component complement(4949479..4951080) Escherichia coli ED1a 7140344 YP_002400757.1 CDS ECED1_5003 NC_011745.1 4951202 4952026 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative Transcriptional regulator 4951202..4952026 Escherichia coli ED1a 7141208 YP_002400758.1 CDS insA NC_011745.1 4952260 4952535 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF 1, IS1 4952260..4952535 Escherichia coli ED1a 7142365 YP_002400759.1 CDS ECED1_5005 NC_011745.1 4952454 4952957 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF 2, IS1 4952454..4952957 Escherichia coli ED1a 7141131 YP_002400760.1 CDS ECED1_5008 NC_011745.1 4953561 4953965 D Evidence 4 : Homologs of previously reported genes of unknown function; putative transposase 4953561..4953965 Escherichia coli ED1a 7139372 YP_002400761.1 CDS ECED1_5009 NC_011745.1 4953962 4954309 D Evidence 4 : Homologs of previously reported genes of unknown function; putative transposase ORF2, IS66 family 4953962..4954309 Escherichia coli ED1a 7142367 YP_002400762.1 CDS ECED1_5010 NC_011745.1 4954358 4955896 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transposase ORF 1, IS66 family 4954358..4955896 Escherichia coli ED1a 7142368 YP_002400763.1 CDS ECED1_5013 NC_011745.1 4956276 4957166 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 complement(4956276..4957166) Escherichia coli ED1a 7142370 YP_002400764.1 CDS ECED1_5014 NC_011745.1 4957163 4957489 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS629 complement(4957163..4957489) Escherichia coli ED1a 7142371 YP_002400765.1 CDS ECED1_5015 NC_011745.1 4957761 4958513 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4957761..4958513) Escherichia coli ED1a 7142372 YP_002400766.1 CDS ykgF NC_011745.1 4958464 4959879 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase subunit with NAD(P)-binding domain and ferridoxin-like domain complement(4958464..4959879) Escherichia coli ED1a 7142373 YP_002400767.1 CDS ECED1_5017 NC_011745.1 4959890 4960609 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4959890..4960609) Escherichia coli ED1a 7140949 YP_002400768.1 CDS ECED1_5018 NC_011745.1 4960659 4962215 R Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; L-lactate permease complement(4960659..4962215) Escherichia coli ED1a 7142374 YP_002400769.1 CDS ECED1_5020 NC_011745.1 4962552 4962743 D Evidence 2b : Function of strongly homologous gene; Product type t : transporter; Periplasmic oligopeptide-binding protein (fragment) 4962552..4962743 Escherichia coli ED1a 7142375 YP_002400770.1 CDS insA NC_011745.1 4962971 4963246 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 4962971..4963246 Escherichia coli ED1a 7142376 YP_002400771.1 CDS ECED1_5026 NC_011745.1 4964439 4964678 D Evidence 7 : Gene remnant; hypothetical protein 4964439..4964678 Escherichia coli ED1a 7142378 YP_002400772.1 CDS ECED1_5027 NC_011745.1 4964823 4965095 D Evidence 7 : Gene remnant; hypothetical protein 4964823..4965095 Escherichia coli ED1a 7142379 YP_002400773.1 CDS ECED1_5028 NC_011745.1 4965329 4965601 R Evidence 2b : Function of strongly homologous gene; Product type rc : receptor; Neurotensin receptor R8 complement(4965329..4965601) Escherichia coli ED1a 7142380 YP_002400774.1 CDS ECED1_5029 NC_011745.1 4965598 4965813 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4965598..4965813) Escherichia coli ED1a 7142381 YP_002400775.1 CDS ECED1_5030 NC_011745.1 4965817 4966200 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4965817..4966200) Escherichia coli ED1a 7142382 YP_002400776.1 CDS ECED1_5031 NC_011745.1 4966197 4966388 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4966197..4966388) Escherichia coli ED1a 7142383 YP_002400777.1 CDS ECED1_5032 NC_011745.1 4966476 4966796 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4966476..4966796) Escherichia coli ED1a 7142384 YP_002400778.1 CDS ECED1_5033 NC_011745.1 4967122 4967346 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4967122..4967346) Escherichia coli ED1a 7142385 YP_002400779.1 CDS ECED1_5034 NC_011745.1 4967580 4968599 R Evidence 2b : Function of strongly homologous gene; PubMedId : 10678953; Product type prc : putative receptor; Iha adhesin (partial) complement(4967580..4968599) Escherichia coli ED1a 7142386 YP_002400780.1 CDS ECED1_5035 NC_011745.1 4968569 4968712 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(4968569..4968712) Escherichia coli ED1a 7142387 YP_002400781.1 CDS ECED1_5036 NC_011745.1 4969073 4969267 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4969073..4969267) Escherichia coli ED1a 7142388 YP_002400782.1 CDS ECED1_5037 NC_011745.1 4969319 4969498 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4969319..4969498) Escherichia coli ED1a 7142389 YP_002400783.1 CDS ECED1_5038 NC_011745.1 4969606 4969884 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4969606..4969884 Escherichia coli ED1a 7142390 YP_002400784.1 CDS ECED1_5039 NC_011745.1 4970139 4970312 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4970139..4970312) Escherichia coli ED1a 7142391 YP_002400785.1 CDS fbpC NC_011745.1 4970570 4971616 R Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import; ferric transporter ATP-binding subunit complement(4970570..4971616) Escherichia coli ED1a 7142392 YP_002400786.1 CDS fbpB NC_011745.1 4971628 4973763 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8807793; Product type m : membrane component; permease component of transport system for ferric iron complement(4971628..4973763) Escherichia coli ED1a 7144134 YP_002400787.1 CDS afuA NC_011745.1 4973775 4974806 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative periplasmic ferric iron-binding protein complement(4973775..4974806) Escherichia coli ED1a 7144133 YP_002400788.1 CDS ECED1_5043 NC_011745.1 4974803 4976119 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 3301805, 1569007, 8349544; Product type pr : putative regulator; putative regulatory protein complement(4974803..4976119) Escherichia coli ED1a 7143670 YP_002400789.1 CDS ECED1_5044 NC_011745.1 4976192 4977733 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1569007; Product type pt : putative transporter; putative sensor histidine protein kinase (uhpB-like) complement(4976192..4977733) Escherichia coli ED1a 7142393 YP_002400790.1 CDS ECED1_5045 NC_011745.1 4977733 4978362 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative response regulator complement(4977733..4978362) Escherichia coli ED1a 7142394 YP_002400791.1 CDS ECED1_5046 NC_011745.1 4978645 4979826 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative prophage integrase complement(4978645..4979826) Escherichia coli ED1a 7142395 YP_002400792.1 CDS ulaE NC_011745.1 4980073 4980816 D UlaE; catalyzes the epimerization of L-ribulose-5-phosphate into L-xylulose-5-phosphate; part of the anaerobic L-ascorbate degradation pathway; L-xylulose 5-phosphate 3-epimerase 4980073..4980816 Escherichia coli ED1a 7142396 YP_002400793.1 CDS sgaE NC_011745.1 4980816 4981502 D catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 4980816..4981502 Escherichia coli ED1a 7138890 YP_002400794.1 CDS yjfY NC_011745.1 4981632 4981907 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4981632..4981907) Escherichia coli ED1a 7138891 YP_002400795.1 CDS rpsF NC_011745.1 4982235 4982630 D binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 4982235..4982630 Escherichia coli ED1a 7139561 YP_002400796.1 CDS priB NC_011745.1 4982637 4982951 D binds single-stranded DNA at the primosome assembly site; primosomal replication protein N 4982637..4982951 Escherichia coli ED1a 7140089 YP_002400797.1 CDS rpsR NC_011745.1 4982956 4983183 D binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 4982956..4983183 Escherichia coli ED1a 7139120 YP_002400798.1 CDS rplI NC_011745.1 4983225 4983674 D in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 4983225..4983674 Escherichia coli ED1a 7140101 YP_002400799.1 CDS ECED1_5054 NC_011745.1 4984076 4984567 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4984076..4984567 Escherichia coli ED1a 7141458 YP_002400800.1 CDS ECED1_5055 NC_011745.1 4984570 4985838 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4984570..4985838 Escherichia coli ED1a 7142397 YP_002400801.1 CDS ECED1_5056 NC_011745.1 4985981 4987258 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative Hexuronate transporter complement(4985981..4987258) Escherichia coli ED1a 7142398 YP_002400802.1 CDS ECED1_5057 NC_011745.1 4987351 4989423 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase complement(4987351..4989423) Escherichia coli ED1a 7142399 YP_002400803.1 CDS ECED1_5058 NC_011745.1 4989420 4990961 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative CoA transferase complement(4989420..4990961) Escherichia coli ED1a 7142400 YP_002400804.1 CDS ECED1_5059 NC_011745.1 4990971 4991747 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acyl-CoA hydratase complement(4990971..4991747) Escherichia coli ED1a 7142401 YP_002400805.1 CDS ECED1_5060 NC_011745.1 4991757 4992599 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein complement(4991757..4992599) Escherichia coli ED1a 7142402 YP_002400806.1 CDS ECED1_5061 NC_011745.1 4992609 4993400 R catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-(acyl-carrier-protein) reductase complement(4992609..4993400) Escherichia coli ED1a 7142403 YP_002400807.1 CDS ytfA NC_011745.1 4993541 4994260 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 4993541..4994260 Escherichia coli ED1a 7142404 YP_002400808.1 CDS ytfB NC_011745.1 4994244 4994882 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8559074; Product type ps : putative structure; putative cell envelope opacity-associated protein complement(4994244..4994882) Escherichia coli ED1a 7143255 YP_002400809.1 CDS fklB NC_011745.1 4995100 4995720 D FKBP-type; rotamase; catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; peptidyl-prolyl cis-trans isomerase 4995100..4995720 Escherichia coli ED1a 7143256 YP_002400810.1 CDS cycA NC_011745.1 4996029 4997432 D involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine; D-alanine/D-serine/glycine permease 4996029..4997432 Escherichia coli ED1a 7144193 YP_002400811.1 CDS ECED1_5066 NC_011745.1 4997338 4997997 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4997338..4997997 Escherichia coli ED1a 7142097 YP_002400812.1 CDS ECED1_5067 NC_011745.1 4998042 4999163 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4998042..4999163 Escherichia coli ED1a 7142405 YP_002400813.1 CDS ytfE NC_011745.1 4999410 5000072 R Involved in anaerobic NO protection and iron metabolism; iron-sulfur cluster repair di-iron protein complement(4999410..5000072) Escherichia coli ED1a 7142406 YP_002400814.1 CDS ytfF NC_011745.1 5000180 5001154 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(5000180..5001154) Escherichia coli ED1a 7143257 YP_002400815.1 CDS ytfG NC_011745.1 5001253 5002113 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14747727; Product type e : enzyme; NAD(P)H:quinone oxidoreductase complement(5001253..5002113) Escherichia coli ED1a 7143258 YP_002400816.1 CDS ytfH NC_011745.1 5002202 5002582 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20088838; Product type pr : putative regulator; putative transcriptional regulator 5002202..5002582 Escherichia coli ED1a 7143259 YP_002400817.1 CDS cpdB NC_011745.1 5002711 5004654 R periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate; bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein complement(5002711..5004654) Escherichia coli ED1a 7143260 YP_002400818.1 CDS cysQ NC_011745.1 5004844 5005584 D catalyzes the formation of AMP from adenosine-3',5'-bisphosphate; adenosine-3'(2'),5'-bisphosphate nucleotidase 5004844..5005584 Escherichia coli ED1a 7142042 YP_002400819.1 CDS ytfJ NC_011745.1 5005574 5006131 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9298646; Product type pr : putative regulator; putative transcriptional regulator complement(5005574..5006131) Escherichia coli ED1a 7143044 YP_002400820.1 CDS ytfK NC_011745.1 5006456 5006662 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5006456..5006662 Escherichia coli ED1a 7143261 YP_002400821.1 CDS ytfL NC_011745.1 5006740 5008083 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(5006740..5008083) Escherichia coli ED1a 7143262 YP_002400822.1 CDS msrA NC_011745.1 5008406 5009044 R this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A complement(5008406..5009044) Escherichia coli ED1a 7143263 YP_002400823.1 CDS ytfM NC_011745.1 5009250 5010983 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 5009250..5010983 Escherichia coli ED1a 7139034 YP_002400824.1 CDS ytfN NC_011745.1 5010980 5014759 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5010980..5014759 Escherichia coli ED1a 7143264 YP_002400825.1 CDS ytfP NC_011745.1 5014762 5015103 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5014762..5015103 Escherichia coli ED1a 7143265 YP_002400826.1 CDS ECED1_5081 NC_011745.1 5015253 5016725 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5015253..5016725 Escherichia coli ED1a 7143266 YP_002400827.1 CDS ppa NC_011745.1 5017139 5017669 R catalyzes the hydrolysis of pyrophosphate to phosphate; inorganic pyrophosphatase complement(5017139..5017669) Escherichia coli ED1a 7142407 YP_002400828.1 CDS ECED1_5083 NC_011745.1 5017641 5017829 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(5017641..5017829) Escherichia coli ED1a 7139095 YP_002400829.1 CDS ytfQ NC_011745.1 5017981 5018937 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9298646; Product type pt : putative transporter; putative sugar ABC transporter periplasmic-binding protein 5017981..5018937 Escherichia coli ED1a 7142408 YP_002400830.1 CDS ytfR NC_011745.1 5019077 5020579 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter ATP-binding protein 5019077..5020579 Escherichia coli ED1a 7143267 YP_002400831.1 CDS ytfT NC_011745.1 5020569 5021921 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter membrane protein 5020569..5021921 Escherichia coli ED1a 7143268 YP_002400832.1 CDS fbp NC_011745.1 5021957 5022955 R catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate; fructose-1,6-bisphosphatase complement(5021957..5022955) Escherichia coli ED1a 7143269 YP_002400833.1 CDS mpl NC_011745.1 5023131 5024504 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96404780, 2843822, 7984428, 8808921; Product type e : enzyme; UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase 5023131..5024504 Escherichia coli ED1a 7144132 YP_002400834.1 CDS yjgA NC_011745.1 5024662 5025213 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5024662..5025213) Escherichia coli ED1a 7139015 YP_002400835.1 CDS pmbA NC_011745.1 5025307 5026659 D protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD; peptidase PmbA 5025307..5026659 Escherichia coli ED1a 7139562 YP_002400836.1 CDS cybC NC_011745.1 5026842 5027228 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1761034, 8499452, 10393541; Product type c : carrier; soluble cytochrome b562 5026842..5027228 Escherichia coli ED1a 7139073 YP_002400837.1 CDS nrdG NC_011745.1 5027273 5027737 R activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions; anaerobic ribonucleotide reductase-activating protein complement(5027273..5027737) Escherichia coli ED1a 7142096 YP_002400838.1 CDS nrdD NC_011745.1 5027895 5030033 R Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase complement(5027895..5030033) Escherichia coli ED1a 7139924 YP_002400839.1 CDS treC NC_011745.1 5030427 5032082 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90264345, 93302496, 8083158, 8421692; Product type e : enzyme; trehalose-6-phosphate hydrolase complement(5030427..5032082) Escherichia coli ED1a 7139921 YP_002400840.1 CDS treB NC_011745.1 5032132 5033553 R phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system trehalose(maltose)-specific transporter subunits IIBC complement(5032132..5033553) Escherichia coli ED1a 7140806 YP_002400841.1 CDS treR NC_011745.1 5033672 5034619 R regulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon; trehalose repressor complement(5033672..5034619) Escherichia coli ED1a 7140805 YP_002400842.1 CDS mgtA NC_011745.1 5034998 5037694 D P-type ATPase involved in magnesium influx; magnesium-transporting ATPase MgtA 5034998..5037694 Escherichia coli ED1a 7140808 YP_002400843.1 CDS yjgF NC_011745.1 5037900 5038286 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12515541, 10493123, 10595546, 9298646; Product type pe : putative enzyme; ketoacid-binding protein complement(5037900..5038286) Escherichia coli ED1a 7142268 YP_002400844.1 CDS pyrI NC_011745.1 5038359 5038820 R involved in the allosteric regulation of aspartate carbamoyltransferase; aspartate carbamoyltransferase regulatory subunit complement(5038359..5038820) Escherichia coli ED1a 7139565 YP_002400845.1 CDS pyrB NC_011745.1 5038833 5039768 R catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase catalytic subunit complement(5038833..5039768) Escherichia coli ED1a 7141238 YP_002400846.1 CDS pyrL NC_011745.1 5039772 5039906 R Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide; pyrBI operon leader peptide complement(5039772..5039906) Escherichia coli ED1a 7141231 YP_002400847.1 CDS ECED1_5101 NC_011745.1 5039996 5040550 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative arginine repressor complement(5039996..5040550) Escherichia coli ED1a 7141239 YP_002400848.1 CDS ECED1_5102 NC_011745.1 5040600 5042048 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5040600..5042048) Escherichia coli ED1a 7142409 YP_002400849.1 CDS arcB NC_011745.1 5042060 5043091 R catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway; ornithine carbamoyltransferase complement(5042060..5043091) Escherichia coli ED1a 7142410 YP_002400850.1 CDS arcC NC_011745.1 5043088 5044044 R reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase complement(5043088..5044044) Escherichia coli ED1a 7142607 YP_002400851.1 CDS ECED1_5105 NC_011745.1 5044031 5045254 R catalyzes the degradation of arginine to citruline and ammonia; arginine deiminase complement(5044031..5045254) Escherichia coli ED1a 7142608 YP_002400852.1 CDS yjgK NC_011745.1 5045929 5046381 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11115104; hypothetical protein 5045929..5046381 Escherichia coli ED1a 7142411 YP_002400853.1 CDS argI NC_011745.1 5046426 5047430 R catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; E. coli K12 has two genes, argF and argI, capable of producing functional ornithine carbamoyltransferase; when both are active in the same cell, the two gene products form a family of four hybrid trimeric isoenzymes designated, FFF, FFI, FII, and III; ornithine carbamoyltransferase subunit F complement(5046426..5047430) Escherichia coli ED1a 7139566 YP_002400854.1 CDS yjgD NC_011745.1 5047592 5048008 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5047592..5048008 Escherichia coli ED1a 7142616 YP_002400855.1 CDS yjgM NC_011745.1 5048185 5048688 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acetyltransferase complement(5048185..5048688) Escherichia coli ED1a 7139564 YP_002400856.1 CDS yjgN NC_011745.1 5048881 5050068 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type m : membrane component; hypothetical protein 5048881..5050068 Escherichia coli ED1a 7139567 YP_002400857.1 CDS valS NC_011745.1 5050115 5052970 R valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase complement(5050115..5052970) Escherichia coli ED1a 7139568 YP_002400858.1 CDS holC NC_011745.1 5052970 5053413 R binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit chi complement(5052970..5053413) Escherichia coli ED1a 7139165 YP_002400859.1 CDS pepA NC_011745.1 5053671 5055182 R catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase complement(5053671..5055182) Escherichia coli ED1a 7139912 YP_002400860.1 CDS yjgP NC_011745.1 5055449 5056549 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 5055449..5056549 Escherichia coli ED1a 7144058 YP_002400861.1 CDS yjgQ NC_011745.1 5056549 5057631 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 5056549..5057631 Escherichia coli ED1a 7139569 YP_002400862.1 CDS yjgR NC_011745.1 5057793 5059295 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ATPase complement(5057793..5059295) Escherichia coli ED1a 7139570 YP_002400863.1 CDS idnR NC_011745.1 5059373 5060371 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9119199, 98324983, 9658018; Product type r : regulator; DNA-binding transcriptional repressor, 5-gluconate-binding complement(5059373..5060371) Escherichia coli ED1a 7139571 YP_002400864.1 CDS idnO NC_011745.1 5061821 5062585 R Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate; gluconate 5-dehydrogenase complement(5061821..5062585) Escherichia coli ED1a 7140230 YP_002400865.1 CDS idnD NC_011745.1 5062609 5063640 R NAD-binding; L-idonate 5-dehydrogenase complement(5062609..5063640) Escherichia coli ED1a 7140227 YP_002400866.1 CDS idnK NC_011745.1 5063857 5064420 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87310381, 93139975, 98324983, 9658018, 14832279; Product type e : enzyme; D-gluconate kinase 5063857..5064420 Escherichia coli ED1a 7140225 YP_002400867.1 CDS yjgB NC_011745.1 5064424 5065443 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12147722; Product type pe : putative enzyme; putative alcohol dehydrogenase, Zn-dependent and NAD(P)-binding complement(5064424..5065443) Escherichia coli ED1a 7140226 YP_002400868.1 CDS ECED1_5124 NC_011745.1 5065518 5065745 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5065518..5065745) Escherichia coli ED1a 7139563 YP_002400869.1 CDS intB NC_011745.1 5065985 5067175 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative integrase; KpLE2 phage-like element 5065985..5067175 Escherichia coli ED1a 7140600 YP_002400870.1 CDS ECED1_5127 NC_011745.1 5068276 5068470 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 5068276..5068470 Escherichia coli ED1a 7142413 YP_002400871.1 CDS yjgZ NC_011745.1 5068502 5068831 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5068502..5068831 Escherichia coli ED1a 7142414 YP_002400872.1 CDS insH NC_011745.1 5069061 5070077 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15766797, 6281654; Product type h : extrachromosomal origin; IS5 transposase and trans-activator; CP4-44 prophage complement(5069061..5070077) Escherichia coli ED1a 7139572 YP_002400873.1 CDS ECED1_5130 NC_011745.1 5069937 5070140 D Evidence 6 : Doubtful CDS; hypothetical protein 5069937..5070140 Escherichia coli ED1a 7141162 YP_002400874.1 CDS ECED1_5131 NC_011745.1 5070095 5070880 D Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF A, IS100 (fragment) 5070095..5070880 Escherichia coli ED1a 7142415 YP_002400875.1 CDS ECED1_5134 NC_011745.1 5071703 5071891 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(5071703..5071891) Escherichia coli ED1a 7142418 YP_002400876.1 CDS ECED1_5135 NC_011745.1 5071863 5072078 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5071863..5072078 Escherichia coli ED1a 7142419 YP_002400877.1 CDS ECED1_5136 NC_011745.1 5072110 5073402 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5072110..5073402) Escherichia coli ED1a 7142420 YP_002400878.1 CDS ECED1_5138 NC_011745.1 5073450 5075453 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14702297; Product type t : transporter; betaine-carnitine-choline transporter family member BetU complement(5073450..5075453) Escherichia coli ED1a 7142421 YP_002400879.1 CDS ECED1_5139 NC_011745.1 5075601 5076419 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS600 complement(5075601..5076419) Escherichia coli ED1a 7142422 YP_002400880.1 CDS insM NC_011745.1 5076455 5076757 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS600 complement(5076455..5076757) Escherichia coli ED1a 7142423 YP_002400881.1 CDS msbB NC_011745.1 5076938 5077882 R Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase complement(5076938..5077882) Escherichia coli ED1a 7141168 YP_002400882.1 CDS virK NC_011745.1 5077947 5078897 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1406277; Product type r : regulator; regulator of virG protein complement(5077947..5078897) Escherichia coli ED1a 7139031 YP_002400883.1 CDS ECED1_5143 NC_011745.1 5078902 5079990 R Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Glycosyl transferase complement(5078902..5079990) Escherichia coli ED1a 7139166 YP_002400884.1 CDS shf NC_011745.1 5079993 5080814 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative polysaccharide deacetylase complement(5079993..5080814) Escherichia coli ED1a 7142424 YP_002400885.1 CDS ECED1_5145 NC_011745.1 5080979 5081323 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS911 5080979..5081323 Escherichia coli ED1a 7143794 YP_002400886.1 CDS ECED1_5147 NC_011745.1 5082396 5083919 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative reverse transcriptase-like protein from putative prophage or plasmid 5082396..5083919 Escherichia coli ED1a 7141170 YP_002400887.1 CDS yjhV NC_011745.1 5084414 5084827 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5084414..5084827 Escherichia coli ED1a 7142427 YP_002400888.1 CDS fecE NC_011745.1 5085385 5086152 R Part of the FecBCDE citrate-dependent iron (III) transport system; iron-dicitrate transporter ATP-binding subunit complement(5085385..5086152) Escherichia coli ED1a 7139578 YP_002400889.1 CDS ECED1_5152 NC_011745.1 5085956 5086120 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5085956..5086120 Escherichia coli ED1a 7144151 YP_002400890.1 CDS fecD NC_011745.1 5086153 5087109 R Ferric citrate binds FecA and is transported across the outer membrane while transmits a signal across the cytoplasmic membrane protein FecR. FecR transmits a signal across the membrane and activates the cytoplasmic FecI that directs the RNA polymerase to express the fecABCDE operon (which encodes the ferric citrate outer membrane receptor and the ferric citrate ABC transporter), as well as fecIR. FecD is one of two (along with FecC) integral membrane protein components of the iron dicitrate ABC transporter.; iron-dicitrate transporter subunit FecD complement(5086153..5087109) Escherichia coli ED1a 7142428 YP_002400891.1 CDS fecC NC_011745.1 5087106 5088104 R part of the FecBCDE citrate-dependent iron (III) transport system; iron-dicitrate transporter permease subunit complement(5087106..5088104) Escherichia coli ED1a 7144150 YP_002400892.1 CDS fecB NC_011745.1 5088101 5089003 R part of the ABC transporter involved in the uptake of citrate-dependent Fe(3+); iron-dicitrate transporter substrate-binding subunit complement(5088101..5089003) Escherichia coli ED1a 7144149 YP_002400893.1 CDS fecA NC_011745.1 5089048 5091372 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90105402, 91072220, 92269759, 2836368; Product type t : transporter; ferric citrate outer membrane transporter; KpLE2 phage-like element complement(5089048..5091372) Escherichia coli ED1a 7144148 YP_002400894.1 CDS fecR NC_011745.1 5091459 5092412 R with FecA forms the FecAR signal transduction system; ferric citrate binds FecA and transmits a signal across the outer membrane to FecR. FecR transmits a signal across the cytoplasmic membrane and activates the sigma 70 protein FecI that directs the RNA polymerase to express the fecABCDE operon; fec operon regulator FecR complement(5091459..5092412) Escherichia coli ED1a 7144147 YP_002400895.1 CDS fecI NC_011745.1 5092409 5092930 R Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor regulates the genes for iron dicitrate transport; RNA polymerase sigma factor FecI complement(5092409..5092930) Escherichia coli ED1a 7144153 YP_002400896.1 CDS insA NC_011745.1 5093222 5093497 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF 1, IS1 5093222..5093497 Escherichia coli ED1a 7144152 YP_002400897.1 CDS insB NC_011745.1 5093416 5093919 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF2, IS1 5093416..5093919 Escherichia coli ED1a 7141133 YP_002400898.1 CDS ECED1_5162 NC_011745.1 5095101 5095310 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5095101..5095310) Escherichia coli ED1a 7141158 YP_002400899.1 CDS ECED1_5163 NC_011745.1 5095674 5097047 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5095674..5097047 Escherichia coli ED1a 7142429 YP_002400900.1 CDS ECED1_5166 NC_011745.1 5098721 5099068 R Evidence 4 : Homologs of previously reported genes of unknown function; putative transposase ORF2, IS66 family complement(5098721..5099068) Escherichia coli ED1a 7142432 YP_002400901.1 CDS ECED1_5167 NC_011745.1 5099065 5099466 R Evidence 4 : Homologs of previously reported genes of unknown function; putative transposase, IS3 family complement(5099065..5099466) Escherichia coli ED1a 7142433 YP_002400902.1 CDS ECED1_5168 NC_011745.1 5099800 5100234 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5099800..5100234) Escherichia coli ED1a 7142434 YP_002400903.1 CDS ECED1_5169 NC_011745.1 5100222 5100629 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5100222..5100629) Escherichia coli ED1a 7142435 YP_002400904.1 CDS ECED1_5170 NC_011745.1 5100883 5101488 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5100883..5101488) Escherichia coli ED1a 7142436 YP_002400905.1 CDS ECED1_5171 NC_011745.1 5102199 5102408 R Evidence 2b : Function of strongly homologous gene; PubMedId : 1956303, 8145648, 1484495; Product type f : factor; hemolysin expression-modulating protein complement(5102199..5102408) Escherichia coli ED1a 7142437 YP_002400906.1 CDS ECED1_5172 NC_011745.1 5102914 5103315 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; putative Prophage CP4-57 regulatory protein 5102914..5103315 Escherichia coli ED1a 7142438 YP_002400907.1 CDS ECED1_5173 NC_011745.1 5103374 5103973 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5103374..5103973 Escherichia coli ED1a 7142439 YP_002400908.1 CDS ECED1_5174 NC_011745.1 5103959 5104195 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5103959..5104195) Escherichia coli ED1a 7142440 YP_002400909.1 CDS ECED1_5175 NC_011745.1 5105467 5106486 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5105467..5106486 Escherichia coli ED1a 7140650 YP_002400910.1 CDS ECED1_5176 NC_011745.1 5106557 5107468 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5106557..5107468 Escherichia coli ED1a 7140710 YP_002400911.1 CDS flu NC_011745.1 5107795 5110923 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20392470, 97257509, 99212225, 2661530, 9298646; Product type h : extrachromosomal origin; antigen 43 (Ag43) phase-variable biofilm formation autotransporter; CP4-44 prophage 5107795..5110923 Escherichia coli ED1a 7142470 YP_002400912.1 CDS ECED1_5178 NC_011745.1 5111038 5113560 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 5111038..5113560 Escherichia coli ED1a 7142151 YP_002400913.1 CDS ECED1_5179 NC_011745.1 5113636 5114091 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5113636..5114091 Escherichia coli ED1a 7140712 YP_002400914.1 CDS ECED1_5181 NC_011745.1 5114212 5114400 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5114212..5114400) Escherichia coli ED1a 7140714 YP_002400915.1 CDS ECED1_5182 NC_011745.1 5114504 5115325 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5114504..5115325 Escherichia coli ED1a 7140715 YP_002400916.1 CDS ECED1_5183 NC_011745.1 5115380 5115865 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7519596; Product type pf : putative factor; putative antirestriction protein (klcA-like) 5115380..5115865 Escherichia coli ED1a 7140716 YP_002400917.1 CDS yeeS NC_011745.1 5115866 5116357 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11053371; Product type pf : putative factor; putative DNA repair protein; CP4-44 prophage 5115866..5116357 Escherichia coli ED1a 7140717 YP_002400918.1 CDS yeeT NC_011745.1 5116420 5116641 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 5116420..5116641 Escherichia coli ED1a 7139389 YP_002400919.1 CDS ECED1_5186 NC_011745.1 5116641 5116754 D Evidence 6 : Doubtful CDS; hypothetical protein 5116641..5116754 Escherichia coli ED1a 7139394 YP_002400920.1 CDS yeeU NC_011745.1 5116804 5117172 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594833; Product type h : extrachromosomal origin; CP4-44 prophage YeeV-YeeU toxin-antitoxin system toxin 5116804..5117172 Escherichia coli ED1a 7140718 YP_002400921.1 CDS yeeV NC_011745.1 5117262 5117636 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594833; Product type h : extrachromosomal origin; toxin of the YeeV-YeeU toxin-antitoxin system; CP4-44 prophage 5117262..5117636 Escherichia coli ED1a 7139399 YP_002400922.1 CDS yeeW NC_011745.1 5117633 5118121 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5117633..5118121 Escherichia coli ED1a 7139404 YP_002400923.1 CDS ECED1_5190 NC_011745.1 5118088 5118330 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5118088..5118330 Escherichia coli ED1a 7139409 YP_002400924.1 CDS ECED1_5191 NC_011745.1 5118415 5118567 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5118415..5118567 Escherichia coli ED1a 7140719 YP_002400925.1 CDS yjhS NC_011745.1 5122882 5123862 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5122882..5123862) Escherichia coli ED1a 7141590 YP_002400926.1 CDS yjhT NC_011745.1 5123927 5125033 R Evidence 4 : Homologs of previously reported genes of unknown function; N-acetylneuraminic acid mutarotase complement(5123927..5125033) Escherichia coli ED1a 7139576 YP_002400927.1 CDS yjhA NC_011745.1 5125053 5125769 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15743943; Product type t : transporter; N-acetylnuraminic acid outer membrane channel protein complement(5125053..5125769) Escherichia coli ED1a 7139577 YP_002400928.1 CDS ECED1_5196 NC_011745.1 5126567 5126974 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5126567..5126974) Escherichia coli ED1a 7139573 YP_002400929.1 CDS fimB NC_011745.1 5127234 5127836 D inversion of on/off regulator of fimA; tyrosine recombinase 5127234..5127836 Escherichia coli ED1a 7140721 YP_002400930.1 CDS fimE NC_011745.1 5128314 5128910 D inversion of on/off regulator of fimA; tyrosine recombinase 5128314..5128910 Escherichia coli ED1a 7144182 YP_002400931.1 CDS fimA NC_011745.1 5129391 5129939 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6146599, 6147250, 90220509, 93106965, 2858471, 6123483; Product type s : structure; major type 1 subunit fimbrin 5129391..5129939 Escherichia coli ED1a 7144185 YP_002400932.1 CDS fimI NC_011745.1 5130004 5130543 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12897022, 11673421, 6147250; Product type s : structure; type 1 pilus biosynthesis fimbrial protein 5130004..5130543 Escherichia coli ED1a 7144181 YP_002400933.1 CDS fimC NC_011745.1 5130580 5131305 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20450729, 90220509, 93155127, 93391362, 1363735, 8104335, 8636962, 9783748; Product type f : factor; chaperone, periplasmic 5130580..5131305 Escherichia coli ED1a 7144186 YP_002400934.1 CDS fimD-fimH NC_011745.1 5131367 5133103 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1970114, 89056689, 93155127, 93391362, 1971261, 2890081, 2900235, 790547; Product type s : structure; outer membrane usher protein FimD/type 1 fimbriae minor component 5131367..5133103 Escherichia coli ED1a 7144183 YP_002400935.1 CDS uxuA NC_011745.1 5133832 5135016 D catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate; mannonate dehydratase 5133832..5135016 Escherichia coli ED1a 7143001 YP_002400936.1 CDS uxuB NC_011745.1 5135097 5136557 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 73203083, 77222076, 14401695; Product type e : enzyme; D-mannonate oxidoreductase, NAD-binding 5135097..5136557 Escherichia coli ED1a 7139158 YP_002400937.1 CDS uxuR NC_011745.1 5136772 5137545 D regulates the expression of uxuBA; DNA-binding transcriptional repressor UxuR 5136772..5137545 Escherichia coli ED1a 7139159 YP_002400938.1 CDS yjiN NC_011745.1 5137674 5138954 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(5137674..5138954) Escherichia coli ED1a 7139160 YP_002400939.1 CDS ECED1_5208 NC_011745.1 5139139 5140059 D Evidence 4 : Homologs of previously reported genes of unknown function; putative transposase 5139139..5140059 Escherichia coli ED1a 7139580 YP_002400940.1 CDS ECED1_5209 NC_011745.1 5140253 5140324 D Evidence 6 : Doubtful CDS; hypothetical protein 5140253..5140324 Escherichia coli ED1a 7140722 YP_002400941.1 CDS ECED1_5210 NC_011745.1 5140339 5142546 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5140339..5142546 Escherichia coli ED1a 7140723 YP_002400942.1 CDS yjiW NC_011745.1 5142593 5142991 R involved in the degradation of RNA; may be involved in the recycling of RNA during the SOS response; endoribonuclease SymE complement(5142593..5142991) Escherichia coli ED1a 7140724 YP_002400943.1 CDS hsdS NC_011745.1 5143155 5144909 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9108149, 2642743; Product type e : enzyme; Type I restriction enzyme EcoAI specificity protein (S protein) (S.EcoAI) complement(5143155..5144909) Escherichia coli ED1a 7141355 YP_002400944.1 CDS hsdM NC_011745.1 5144909 5146414 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8412658, 1409708; Product type e : enzyme; Type I restriction enzyme EcoEI M protein (M.EcoEI) complement(5144909..5146414) Escherichia coli ED1a 7140165 YP_002400945.1 CDS hsdR NC_011745.1 5146445 5148877 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9837717, 10373579, 10733903, 8412658; Product type e : enzyme; Type I restriction enzyme EcoAI R protein (R.EcoAI) complement(5146445..5148877) Escherichia coli ED1a 7140163 YP_002400946.1 CDS ECED1_5216 NC_011745.1 5149509 5150807 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5149509..5150807 Escherichia coli ED1a 7140725 YP_002400947.1 CDS yjiA NC_011745.1 5150876 5151832 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14696199; Product type pe : putative enzyme; putative GTP-binding protein YjiA complement(5150876..5151832) Escherichia coli ED1a 7140726 YP_002400948.1 CDS yjiX NC_011745.1 5151843 5152046 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5151843..5152046) Escherichia coli ED1a 7139579 YP_002400949.1 CDS yjiY NC_011745.1 5152164 5154314 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(5152164..5154314) Escherichia coli ED1a 7139582 YP_002400950.1 CDS tsr NC_011745.1 5154691 5156355 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20015410, 89034150, 91317710, 10466731, 2033064, 6213619, 6402709, 8384293; Product type r : regulator; methyl-accepting chemotaxis protein I, serine sensor receptor 5154691..5156355 Escherichia coli ED1a 7139583 YP_002400951.1 CDS ECED1_5221 NC_011745.1 5156398 5157669 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative C4-dicarboxylate transporter, large permease (dctM-like) complement(5156398..5157669) Escherichia coli ED1a 7140836 YP_002400952.1 CDS ECED1_5222 NC_011745.1 5157666 5158139 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative tripartite ATP-independent periplasmic transporter (dctQ-like) complement(5157666..5158139) Escherichia coli ED1a 7140727 YP_002400953.1 CDS ECED1_5223 NC_011745.1 5158203 5159174 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative C4-dicarboxylate-binding periplasmic protein (dctP-like) complement(5158203..5159174) Escherichia coli ED1a 7140728 YP_002400954.1 CDS ECED1_5224 NC_011745.1 5159844 5161517 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative Na(+)/H(+) exchanger 5159844..5161517 Escherichia coli ED1a 7140729 YP_002400955.1 CDS yjjM NC_011745.1 5161688 5162593 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(5161688..5162593) Escherichia coli ED1a 7140730 YP_002400956.1 CDS yjjN NC_011745.1 5162732 5163754 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase, Zn-dependent and NAD(P)-binding 5162732..5163754 Escherichia coli ED1a 7139590 YP_002400957.1 CDS mdoB NC_011745.1 5163891 5166182 R catalyzes the transfer of phosphoglycerol to the glucan backbone; phosphoglycerol transferase I complement(5163891..5166182) Escherichia coli ED1a 7139591 YP_002400958.1 CDS yjjA NC_011745.1 5166436 5166930 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5166436..5166930) Escherichia coli ED1a 7142222 YP_002400959.1 CDS dnaC NC_011745.1 5166979 5167716 R acts to load the DnaB helicase onto the initiation site during DNA replication; DNA replication protein DnaC complement(5166979..5167716) Escherichia coli ED1a 7139584 YP_002400960.1 CDS dnaT NC_011745.1 5167719 5168258 R This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'; primosomal protein DnaI complement(5167719..5168258) Escherichia coli ED1a 7140504 YP_002400961.2 CDS yjjB NC_011745.1 5168366 5168839 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(5168366..5168839) Escherichia coli ED1a 7140511 YP_002400962.1 CDS yjjP NC_011745.1 5168830 5169600 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(5168830..5169600) Escherichia coli ED1a 7139585 YP_002400963.1 CDS insA NC_011745.1 5170267 5170542 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF 1, IS1 5170267..5170542 Escherichia coli ED1a 7139592 YP_002400964.1 CDS insB NC_011745.1 5170461 5170964 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF2, IS1 5170461..5170964 Escherichia coli ED1a 7141134 YP_002400965.1 CDS yjjQ NC_011745.1 5170997 5171722 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 5170997..5171722 Escherichia coli ED1a 7141159 YP_002400966.1 CDS bglJ NC_011745.1 5171734 5172357 D regulator for the transport and utilization of the aromatic beta-glucosides arbutin and silicin; DNA-binding transcriptional activator BglJ 5171734..5172357 Escherichia coli ED1a 7139547 YP_002400967.1 CDS fhuF NC_011745.1 5172395 5173183 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11931550, 14756576, 3323834, 9990318; Product type c : carrier; ferric iron reductase involved in ferric hydroximate transport complement(5172395..5173183) Escherichia coli ED1a 7140448 YP_002400968.1 CDS ECED1_5238 NC_011745.1 5173213 5173560 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5173213..5173560 Escherichia coli ED1a 7144174 YP_002400969.1 CDS ECED1_5239 NC_011745.1 5173416 5173571 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5173416..5173571 Escherichia coli ED1a 7140731 YP_002400970.1 CDS rsmC NC_011745.1 5174121 5175152 R 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit; 16S ribosomal RNA m2G1207 methyltransferase complement(5174121..5175152) Escherichia coli ED1a 7140601 YP_002400971.1 CDS holD NC_011745.1 5175255 5175668 D with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit psi 5175255..5175668 Escherichia coli ED1a 7140115 YP_002400972.1 CDS rimI NC_011745.1 5175637 5176083 D alanine acetyltransferase that specifically acetylates ribosomal protein S18; ribosomal-protein-alanine N-acetyltransferase 5175637..5176083 Escherichia coli ED1a 7139913 YP_002400973.1 CDS yjjG NC_011745.1 5176098 5176775 D manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily; nucleotidase 5176098..5176775 Escherichia coli ED1a 7141416 YP_002400974.1 CDS prfC NC_011745.1 5176866 5178455 D stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 5176866..5178455 Escherichia coli ED1a 7139586 YP_002400975.1 CDS osmY NC_011745.1 5178848 5179453 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1317380, 8253679, 9298646, 9600841; Product type cp : cell process; periplasmic protein 5178848..5179453 Escherichia coli ED1a 7139117 YP_002400976.1 CDS ytjA NC_011745.1 5179562 5179741 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5179562..5179741 Escherichia coli ED1a 7139990 YP_002400977.1 CDS yjjU NC_011745.1 5179863 5180936 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative esterase 5179863..5180936 Escherichia coli ED1a 7143270 YP_002400978.1 CDS yjjV NC_011745.1 5180933 5181712 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative deoxyribonuclease YjjV 5180933..5181712 Escherichia coli ED1a 7142028 YP_002400979.1 CDS yjjW NC_011745.1 5181929 5182792 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative pyruvate formate lyase activating enzyme complement(5181929..5182792) Escherichia coli ED1a 7140940 YP_002400980.1 CDS yjjI NC_011745.1 5182764 5184314 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5182764..5184314) Escherichia coli ED1a 7140941 YP_002400981.1 CDS deoC NC_011745.1 5184572 5185351 D catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 5184572..5185351 Escherichia coli ED1a 7139587 YP_002400982.1 CDS deoA NC_011745.1 5185429 5186751 D Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate; thymidine phosphorylase 5185429..5186751 Escherichia coli ED1a 7143091 YP_002400983.1 CDS deoB NC_011745.1 5186803 5188026 D catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 5186803..5188026 Escherichia coli ED1a 7143089 YP_002400984.1 CDS deoD NC_011745.1 5188083 5188802 D catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 5188083..5188802 Escherichia coli ED1a 7143090 YP_002400985.1 CDS yjjJ NC_011745.1 5188969 5190300 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; hypothetical protein 5188969..5190300 Escherichia coli ED1a 7143092 YP_002400986.1 CDS lplA NC_011745.1 5190301 5191317 R Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl on the lipoate-dependent enzymes. Creates an amide linkage that joins the free carboxyl group of lipoic acid to the epsilon-amino group of a specific lysine residue in lipoyl domain of apoproteins; lipoate-protein ligase A complement(5190301..5191317) Escherichia coli ED1a 7139588 YP_002400987.1 CDS ytjB NC_011745.1 5191345 5191989 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2684780; hypothetical protein complement(5191345..5191989) Escherichia coli ED1a 7141913 YP_002400988.1 CDS serB NC_011745.1 5192095 5193063 D catalyzes the formation of serine from O-phosphoserine; phosphoserine phosphatase 5192095..5193063 Escherichia coli ED1a 7143271 YP_002400989.1 CDS radA NC_011745.1 5193112 5194494 D Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 5193112..5194494 Escherichia coli ED1a 7141398 YP_002400990.1 CDS nadR NC_011745.1 5194515 5195747 D catalyzes the formation of NAD(+) from nicotinamide ribonucleotide; nicotinamide-nucleotide adenylyltransferase 5194515..5195747 Escherichia coli ED1a 7141250 YP_002400991.1 CDS ECED1_5262 NC_011745.1 5195761 5196171 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5195761..5196171 Escherichia coli ED1a 7140335 YP_002400992.1 CDS ECED1_5263 NC_011745.1 5196173 5196457 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5196173..5196457 Escherichia coli ED1a 7140733 YP_002400993.1 CDS yjjK NC_011745.1 5196513 5198180 R ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; putative ABC transporter ATP-binding protein complement(5196513..5198180) Escherichia coli ED1a 7140734 YP_002400994.1 CDS slt NC_011745.1 5198387 5200324 D catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan; lytic murein transglycosylase 5198387..5200324 Escherichia coli ED1a 7139589 YP_002400995.1 CDS trpR NC_011745.1 5200414 5200740 D When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription; Trp operon repressor 5200414..5200740 Escherichia coli ED1a 7143804 YP_002400996.1 CDS yjjX NC_011745.1 5200813 5201349 R pyrophosphatase; has activity against dUTP and dITP; the crystal structure of the Vibrio protein showed similarity to Methanococcus janaschii Mj0226; in Vibrio cholerae this gene is part of the Mba operon that is involved in regulation and maintenance of biofilms; in Escherichia coli overexpression of this gene leads to resistance to an HMP analog; NTPase complement(5200813..5201349) Escherichia coli ED1a 7140825 YP_002400997.1 CDS ytjC NC_011745.1 5201392 5202039 D catalyzes reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate; phosphoglycerate mutase 5201392..5202039 Escherichia coli ED1a 7140942 YP_002400998.1 CDS rob NC_011745.1 5202036 5202905 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20264525, 20309711, 93194823, 96405618, 8449900; Product type r : regulator; DNA-binding transcriptional activator complement(5202036..5202905) Escherichia coli ED1a 7143272 YP_002400999.1 CDS creA NC_011745.1 5203116 5203589 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3531171, 8449900; hypothetical protein 5203116..5203589 Escherichia coli ED1a 7141444 YP_002401000.1 CDS creB NC_011745.1 5203602 5204291 D response regulator in two-component regulatory system with CreC; CreB protein is phosphorylated by sensor protein phospho-CreC; involved in catabolic regulation; DNA-binding response regulator CreB 5203602..5204291 Escherichia coli ED1a 7142050 YP_002401001.1 CDS creC NC_011745.1 5204291 5205715 D part of a two-component regulatory system with CreB or PhoB; involved in catabolic regulation; sensory histidine kinase CreC 5204291..5205715 Escherichia coli ED1a 7142051 YP_002401002.1 CDS creD NC_011745.1 5205773 5207125 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88216172, 2835585, 2984198, 3531171; Product type m : membrane component; hypothetical protein 5205773..5207125 Escherichia coli ED1a 7142052 YP_002401003.1 CDS arcA NC_011745.1 5207185 5207901 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15028693, 21167794, 21317451, 91008980, 91358353, 92380937, 9514749, 9632255, 2984198, 7565118, 9298646; Product type r : regulator; two-component response regulator complement(5207185..5207901) Escherichia coli ED1a 7142053 YP_002401004.1 CDS yjtD NC_011745.1 5208537 5209223 D member of the SPOUT superfamily of methyltransferases; putative RNA methyltransferase 5208537..5209223 Escherichia coli ED1a 7142605 YP_002401005.1 CDS thrL NC_011745.1 5209437 5209502 D involved in threonine biosynthesis; controls the expression of the thrLABC operon; thr operon leader peptide 5209437..5209502 Escherichia coli ED1a 7140943 ECED1_tRNA1 tRNA ECED1_tRNA1 NC_011745.1 230109 230185 D tRNA-Ile 230109..230185 Escherichia coli ED1a 7142818 ECED1_tRNA2 tRNA ECED1_tRNA2 NC_011745.1 230228 230303 D tRNA-Ala 230228..230303 Escherichia coli ED1a 7140773 ECED1_tRNA3 tRNA ECED1_tRNA3 NC_011745.1 233654 233730 D tRNA-Asp 233654..233730 Escherichia coli ED1a 7140738 ECED1_tRNA4 tRNA ECED1_tRNA4 NC_011745.1 241877 241953 D tRNA-Asp 241877..241953 Escherichia coli ED1a 7140510 ECED1_tRNA5 tRNA ECED1_tRNA5 NC_011745.1 296991 297066 D tRNA-Thr 296991..297066 Escherichia coli ED1a 7139127 ECED1_tRNA6 tRNA ECED1_tRNA6 NC_011745.1 376514 376594 D tRNA-OTHER 376514..376594 Escherichia coli ED1a 7143404 ECED1_tRNA7 tRNA ECED1_tRNA7 NC_011745.1 572859 572935 D tRNA-Arg 572859..572935 Escherichia coli ED1a 7141846 ECED1_tRNA91 tRNA ECED1_tRNA91 NC_011745.1 675907 675981 R tRNA-Gln complement(675907..675981) Escherichia coli ED1a 7140861 ECED1_tRNA90 tRNA ECED1_tRNA90 NC_011745.1 676019 676093 R tRNA-Gln complement(676019..676093) Escherichia coli ED1a 7140640 ECED1_tRNA89 tRNA ECED1_tRNA89 NC_011745.1 676142 676218 R tRNA-Met complement(676142..676218) Escherichia coli ED1a 7140639 ECED1_tRNA88 tRNA ECED1_tRNA88 NC_011745.1 676234 676308 R tRNA-Gln complement(676234..676308) Escherichia coli ED1a 7140637 ECED1_tRNA87 tRNA ECED1_tRNA87 NC_011745.1 676343 676417 R tRNA-Gln complement(676343..676417) Escherichia coli ED1a 7140636 ECED1_tRNA86 tRNA ECED1_tRNA86 NC_011745.1 676441 676525 R tRNA-Leu complement(676441..676525) Escherichia coli ED1a 7140635 ECED1_tRNA85 tRNA ECED1_tRNA85 NC_011745.1 676536 676612 R tRNA-Met complement(676536..676612) Escherichia coli ED1a 7140634 ECED1_tRNA8 tRNA ECED1_tRNA8 NC_011745.1 740095 740170 D tRNA-Lys 740095..740170 Escherichia coli ED1a 7138950 ECED1_tRNA9 tRNA ECED1_tRNA9 NC_011745.1 740206 740281 D tRNA-Val 740206..740281 Escherichia coli ED1a 7140627 ECED1_tRNA10 tRNA ECED1_tRNA10 NC_011745.1 740284 740359 D tRNA-Lys 740284..740359 Escherichia coli ED1a 7140638 ECED1_tRNA11 tRNA ECED1_tRNA11 NC_011745.1 740411 740486 D tRNA-Val 740411..740486 Escherichia coli ED1a 7140774 ECED1_tRNA12 tRNA ECED1_tRNA12 NC_011745.1 740490 740565 D tRNA-Lys 740490..740565 Escherichia coli ED1a 7140775 ECED1_tRNA13 tRNA ECED1_tRNA13 NC_011745.1 740614 740689 D tRNA-Lys 740614..740689 Escherichia coli ED1a 7140776 ECED1_tRNA14 tRNA ECED1_tRNA14 NC_011745.1 740723 740798 D tRNA-Lys 740723..740798 Escherichia coli ED1a 7140777 ECED1_tRNA84 tRNA ECED1_tRNA84 NC_011745.1 892184 892271 R tRNA-Ser complement(892184..892271) Escherichia coli ED1a 7141861 ECED1_tRNA15 tRNA ECED1_tRNA15 NC_011745.1 1045867 1045942 D tRNA-Met 1045867..1045942 Escherichia coli ED1a 7141081 ECED1_tRNA16 tRNA ECED1_tRNA16 NC_011745.1 1045952 1046028 D tRNA-Arg 1045952..1046028 Escherichia coli ED1a 7140779 ECED1_tRNA17 tRNA ECED1_tRNA17 NC_011745.1 1046042 1046118 D tRNA-Arg 1046042..1046118 Escherichia coli ED1a 7140780 ECED1_tRNA83 tRNA ECED1_tRNA83 NC_011745.1 1074846 1074933 R tRNA-Ser complement(1074846..1074933) Escherichia coli ED1a 7143490 ECED1_tRNA82 tRNA ECED1_tRNA82 NC_011745.1 1183559 1183646 R tRNA-Ser complement(1183559..1183646) Escherichia coli ED1a 7142529 ECED1_tRNA81 tRNA ECED1_tRNA81 NC_011745.1 1369418 1369502 R tRNA-Tyr complement(1369418..1369502) Escherichia coli ED1a 7140134 ECED1_tRNA80 tRNA ECED1_tRNA80 NC_011745.1 1369536 1369620 R tRNA-Tyr complement(1369536..1369620) Escherichia coli ED1a 7140629 ECED1_tRNA18 tRNA ECED1_tRNA18 NC_011745.1 1404421 1404496 D tRNA-Met 1404421..1404496 Escherichia coli ED1a 7142567 ECED1_tRNA19 tRNA ECED1_tRNA19 NC_011745.1 1404506 1404582 D tRNA-Arg 1404506..1404582 Escherichia coli ED1a 7140782 ECED1_tRNA20 tRNA ECED1_tRNA20 NC_011745.1 1823927 1824003 D tRNA-Val 1823927..1824003 Escherichia coli ED1a 7139295 ECED1_tRNA21 tRNA ECED1_tRNA21 NC_011745.1 1824008 1824084 D tRNA-Val 1824008..1824084 Escherichia coli ED1a 7140785 ECED1_tRNA79 tRNA ECED1_tRNA79 NC_011745.1 2109058 2109144 R tRNA-Leu complement(2109058..2109144) Escherichia coli ED1a 7141701 ECED1_tRNA78 tRNA ECED1_tRNA78 NC_011745.1 2109157 2109230 R tRNA-Cys complement(2109157..2109230) Escherichia coli ED1a 7140626 ECED1_tRNA77 tRNA ECED1_tRNA77 NC_011745.1 2109285 2109360 R tRNA-Gly complement(2109285..2109360) Escherichia coli ED1a 7140625 ECED1_tRNA76 tRNA ECED1_tRNA76 NC_011745.1 2163000 2163089 R tRNA-Ser complement(2163000..2163089) Escherichia coli ED1a 7140263 ECED1_tRNA22 tRNA ECED1_tRNA22 NC_011745.1 2164081 2164156 D tRNA-Asn 2164081..2164156 Escherichia coli ED1a 7140566 ECED1_tRNA75 tRNA ECED1_tRNA75 NC_011745.1 2235741 2235816 R tRNA-Asn complement(2235741..2235816) Escherichia coli ED1a 7140040 ECED1_tRNA23 tRNA ECED1_tRNA23 NC_011745.1 2237565 2237640 D tRNA-Asn 2237565..2237640 Escherichia coli ED1a 7141103 ECED1_tRNA24 tRNA ECED1_tRNA24 NC_011745.1 2269301 2269376 D tRNA-Asn 2269301..2269376 Escherichia coli ED1a 7140329 ECED1_tRNA74 tRNA ECED1_tRNA74 NC_011745.1 2478983 2479057 R tRNA-OTHER complement(2478983..2479057) Escherichia coli ED1a 7140662 ECED1_tRNA25 tRNA ECED1_tRNA25 NC_011745.1 2568782 2568858 D tRNA-Pro 2568782..2568858 Escherichia coli ED1a 7143958 ECED1_tRNA26 tRNA ECED1_tRNA26 NC_011745.1 2751263 2751337 D tRNA-Arg 2751263..2751337 Escherichia coli ED1a 7144010 ECED1_tRNA73 tRNA ECED1_tRNA73 NC_011745.1 2792699 2792774 R tRNA-Ala complement(2792699..2792774) Escherichia coli ED1a 7143876 ECED1_tRNA27 tRNA ECED1_tRNA27 NC_011745.1 2795473 2795548 D tRNA-Val 2795473..2795548 Escherichia coli ED1a 7142987 ECED1_tRNA28 tRNA ECED1_tRNA28 NC_011745.1 2795593 2795668 D tRNA-Val 2795593..2795668 Escherichia coli ED1a 7140569 ECED1_tRNA29 tRNA ECED1_tRNA29 NC_011745.1 2795715 2795790 D tRNA-Val 2795715..2795790 Escherichia coli ED1a 7140570 ECED1_tRNA30 tRNA ECED1_tRNA30 NC_011745.1 2795795 2795870 D tRNA-Lys 2795795..2795870 Escherichia coli ED1a 7140571 ECED1_tRNA72 tRNA ECED1_tRNA72 NC_011745.1 2989709 2989784 R tRNA-Glu complement(2989709..2989784) Escherichia coli ED1a 7143298 ECED1_tRNA71 tRNA ECED1_tRNA71 NC_011745.1 3082499 3082575 R tRNA-Arg complement(3082499..3082575) Escherichia coli ED1a 7140307 ECED1_tRNA70 tRNA ECED1_tRNA70 NC_011745.1 3082639 3082715 R tRNA-Arg complement(3082639..3082715) Escherichia coli ED1a 7140618 ECED1_tRNA69 tRNA ECED1_tRNA69 NC_011745.1 3082778 3082854 R tRNA-Arg complement(3082778..3082854) Escherichia coli ED1a 7140617 ECED1_tRNA68 tRNA ECED1_tRNA68 NC_011745.1 3082919 3082995 R tRNA-Arg complement(3082919..3082995) Escherichia coli ED1a 7140615 ECED1_tRNA67 tRNA ECED1_tRNA67 NC_011745.1 3082999 3083091 R tRNA-Ser complement(3082999..3083091) Escherichia coli ED1a 7140614 ECED1_tRNA31 tRNA ECED1_tRNA31 NC_011745.1 3204666 3204742 D tRNA-Met 3204666..3204742 Escherichia coli ED1a 7138990 ECED1_tRNA32 tRNA ECED1_tRNA32 NC_011745.1 3204776 3204852 D tRNA-Met 3204776..3204852 Escherichia coli ED1a 7140574 ECED1_tRNA33 tRNA ECED1_tRNA33 NC_011745.1 3204886 3204962 D tRNA-Met 3204886..3204962 Escherichia coli ED1a 7140575 ECED1_tRNA66 tRNA ECED1_tRNA66 NC_011745.1 3264676 3264749 R tRNA-Gly complement(3264676..3264749) Escherichia coli ED1a 7141181 ECED1_tRNA34 tRNA ECED1_tRNA34 NC_011745.1 3374807 3374882 D tRNA-Phe 3374807..3374882 Escherichia coli ED1a 7140320 ECED1_tRNA35 tRNA ECED1_tRNA35 NC_011745.1 3664678 3664753 D tRNA-Met 3664678..3664753 Escherichia coli ED1a 7139664 ECED1_tRNA65 tRNA ECED1_tRNA65 NC_011745.1 3760899 3760975 R tRNA-Met complement(3760899..3760975) Escherichia coli ED1a 7139475 ECED1_tRNA64 tRNA ECED1_tRNA64 NC_011745.1 3764756 3764842 R tRNA-Leu complement(3764756..3764842) Escherichia coli ED1a 7139487 ECED1_tRNA63 tRNA ECED1_tRNA63 NC_011745.1 3864951 3865026 R tRNA-Thr complement(3864951..3865026) Escherichia coli ED1a 7140736 ECED1_tRNA62 tRNA ECED1_tRNA62 NC_011745.1 3868338 3868413 R tRNA-Ala complement(3868338..3868413) Escherichia coli ED1a 7143297 ECED1_tRNA61 tRNA ECED1_tRNA61 NC_011745.1 3868456 3868532 R tRNA-Ile complement(3868456..3868532) Escherichia coli ED1a 7140608 ECED1_tRNA60 tRNA ECED1_tRNA60 NC_011745.1 4144774 4144850 R tRNA-Pro complement(4144774..4144850) Escherichia coli ED1a 7140514 ECED1_tRNA36 tRNA ECED1_tRNA36 NC_011745.1 4276398 4276488 D tRNA-Sec 4276398..4276488 Escherichia coli ED1a 7139720 ECED1_tRNA37 tRNA ECED1_tRNA37 NC_011745.1 4380238 4380313 D tRNA-Glu 4380238..4380313 Escherichia coli ED1a 7142819 ECED1_tRNA38 tRNA ECED1_tRNA38 NC_011745.1 4383674 4383750 D tRNA-Asp 4383674..4383750 Escherichia coli ED1a 7140739 ECED1_tRNA39 tRNA ECED1_tRNA39 NC_011745.1 4383759 4383834 D tRNA-Trp 4383759..4383834 Escherichia coli ED1a 7140581 ECED1_tRNA40 tRNA ECED1_tRNA40 NC_011745.1 4418303 4418379 D tRNA-Arg 4418303..4418379 Escherichia coli ED1a 7139753 ECED1_tRNA41 tRNA ECED1_tRNA41 NC_011745.1 4418438 4418513 D tRNA-His 4418438..4418513 Escherichia coli ED1a 7140584 ECED1_tRNA42 tRNA ECED1_tRNA42 NC_011745.1 4418534 4418620 D tRNA-Leu 4418534..4418620 Escherichia coli ED1a 7140585 ECED1_tRNA43 tRNA ECED1_tRNA43 NC_011745.1 4418663 4418739 D tRNA-Pro 4418663..4418739 Escherichia coli ED1a 7140586 ECED1_tRNA44 tRNA ECED1_tRNA44 NC_011745.1 4494014 4494090 D tRNA-Ile 4494014..4494090 Escherichia coli ED1a 7142820 ECED1_tRNA45 tRNA ECED1_tRNA45 NC_011745.1 4494133 4494208 D tRNA-Ala 4494133..4494208 Escherichia coli ED1a 7140588 ECED1_tRNA46 tRNA ECED1_tRNA46 NC_011745.1 4628889 4628964 D tRNA-Glu 4628889..4628964 Escherichia coli ED1a 7142821 ECED1_tRNA47 tRNA ECED1_tRNA47 NC_011745.1 4635739 4635814 D tRNA-Thr 4635739..4635814 Escherichia coli ED1a 7139384 ECED1_tRNA48 tRNA ECED1_tRNA48 NC_011745.1 4635823 4635907 D tRNA-Tyr 4635823..4635907 Escherichia coli ED1a 7140591 ECED1_tRNA49 tRNA ECED1_tRNA49 NC_011745.1 4636024 4636098 D tRNA-Gly 4636024..4636098 Escherichia coli ED1a 7140592 ECED1_tRNA50 tRNA ECED1_tRNA50 NC_011745.1 4636105 4636180 D tRNA-Thr 4636105..4636180 Escherichia coli ED1a 7140593 ECED1_tRNA51 tRNA ECED1_tRNA51 NC_011745.1 4669059 4669134 D tRNA-Glu 4669059..4669134 Escherichia coli ED1a 7142822 ECED1_tRNA59 tRNA ECED1_tRNA59 NC_011745.1 4881199 4881274 R tRNA-Phe complement(4881199..4881274) Escherichia coli ED1a 7141182 ECED1_tRNA52 tRNA ECED1_tRNA52 NC_011745.1 4910140 4910215 D tRNA-Gly 4910140..4910215 Escherichia coli ED1a 7139986 ECED1_tRNA53 tRNA ECED1_tRNA53 NC_011745.1 4910252 4910327 D tRNA-Gly 4910252..4910327 Escherichia coli ED1a 7140597 ECED1_tRNA54 tRNA ECED1_tRNA54 NC_011745.1 4910363 4910438 D tRNA-Gly 4910363..4910438 Escherichia coli ED1a 7140598 ECED1_tRNA55 tRNA ECED1_tRNA55 NC_011745.1 5065639 5065723 D tRNA-Leu 5065639..5065723 Escherichia coli ED1a 7142412 ECED1_tRNA58 tRNA ECED1_tRNA58 NC_011745.1 5173599 5173685 R tRNA-Leu complement(5173599..5173685) Escherichia coli ED1a 7140732 ECED1_tRNA57 tRNA ECED1_tRNA57 NC_011745.1 5173720 5173806 R tRNA-Leu complement(5173720..5173806) Escherichia coli ED1a 7140603 ECED1_tRNA56 tRNA ECED1_tRNA56 NC_011745.1 5173835 5173921 R tRNA-Leu complement(5173835..5173921) Escherichia coli ED1a 7140602 ECED1_16S_3 rRNA ECED1_16S_3 NC_011745.1 228499 230040 D ribosomal RNA 16S 228499..230040 Escherichia coli ED1a 7142994 ECED1_23S_3 rRNA ECED1_23S_3 NC_011745.1 230487 233390 D ribosomal RNA 23S 230487..233390 Escherichia coli ED1a 7140784 ECED1_5S_4 rRNA ECED1_5S_4 NC_011745.1 233483 233602 D ribosomal RNA 5S 233483..233602 Escherichia coli ED1a 7143299 ECED1_5S_3 rRNA ECED1_5S_3 NC_011745.1 2986400 2986519 R ribosomal RNA 5S complement(2986400..2986519) Escherichia coli ED1a 7143891 ECED1_23S_2 rRNA ECED1_23S_2 NC_011745.1 2986612 2989515 R ribosomal RNA 23S complement(2986612..2989515) Escherichia coli ED1a 7140737 ECED1_16S_2 rRNA ECED1_16S_2 NC_011745.1 2989870 2991411 R ribosomal RNA 16S complement(2989870..2991411) Escherichia coli ED1a 7140619 ECED1_5S_2 rRNA ECED1_5S_2 NC_011745.1 3864798 3864910 R ribosomal RNA 5S complement(3864798..3864910) Escherichia coli ED1a 7140647 ECED1_5S_1 rRNA ECED1_5S_1 NC_011745.1 3865039 3865158 R ribosomal RNA 5S complement(3865039..3865158) Escherichia coli ED1a 7140609 ECED1_23S_1 rRNA ECED1_23S_1 NC_011745.1 3865251 3868154 R ribosomal RNA 23S complement(3865251..3868154) Escherichia coli ED1a 7140735 ECED1_16S_1 rRNA ECED1_16S_1 NC_011745.1 3868601 3870142 R ribosomal RNA 16S complement(3868601..3870142) Escherichia coli ED1a 7140607 ECED1_16S_4 rRNA ECED1_16S_4 NC_011745.1 4378611 4380152 D ribosomal RNA 16S 4378611..4380152 Escherichia coli ED1a 7139750 ECED1_23S_4 rRNA ECED1_23S_4 NC_011745.1 4380507 4383410 D ribosomal RNA 23S 4380507..4383410 Escherichia coli ED1a 7140580 ECED1_5S_5 rRNA ECED1_5S_5 NC_011745.1 4383503 4383622 D ribosomal RNA 5S 4383503..4383622 Escherichia coli ED1a 7143300 ECED1_16S_5 rRNA ECED1_16S_5 NC_011745.1 4492404 4493945 D ribosomal RNA 16S 4492404..4493945 Escherichia coli ED1a 7139871 ECED1_23S_5 rRNA ECED1_23S_5 NC_011745.1 4494392 4497295 D ribosomal RNA 23S 4494392..4497295 Escherichia coli ED1a 7140589 ECED1_5S_6 rRNA ECED1_5S_6 NC_011745.1 4497388 4497507 D ribosomal RNA 5S 4497388..4497507 Escherichia coli ED1a 7143301 ECED1_16S_6 rRNA ECED1_16S_6 NC_011745.1 4627262 4628803 D ribosomal RNA 16S 4627262..4628803 Escherichia coli ED1a 7139052 ECED1_23S_6 rRNA ECED1_23S_6 NC_011745.1 4629158 4632061 D ribosomal RNA 23S 4629158..4632061 Escherichia coli ED1a 7140590 ECED1_5S_7 rRNA ECED1_5S_7 NC_011745.1 4632154 4632273 D ribosomal RNA 5S 4632154..4632273 Escherichia coli ED1a 7143302 ECED1_16S_7 rRNA ECED1_16S_7 NC_011745.1 4667432 4668973 D ribosomal RNA 16S 4667432..4668973 Escherichia coli ED1a 7141219 ECED1_23S_7 rRNA ECED1_23S_7 NC_011745.1 4669328 4672231 D ribosomal RNA 23S 4669328..4672231 Escherichia coli ED1a 7140596 ECED1_5S_8 rRNA ECED1_5S_8 NC_011745.1 4672324 4672443 D ribosomal RNA 5S 4672324..4672443 Escherichia coli ED1a 7143303