-- dump date   	20140619_082145
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
316401000001	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
316401000002	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
316401000003	putative catalytic residues [active]
316401000004	putative nucleotide binding site [chemical binding]; other site
316401000005	putative aspartate binding site [chemical binding]; other site
316401000006	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
316401000007	dimer interface [polypeptide binding]; other site
316401000008	putative threonine allosteric regulatory site; other site
316401000009	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
316401000010	putative threonine allosteric regulatory site; other site
316401000011	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
316401000012	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
316401000013	PS00324 Aspartokinase signature.
316401000014	PS01042 Homoserine dehydrogenase signature.
316401000015	homoserine kinase; Region: thrB; TIGR00191
316401000016	Protein of unknown function; Region: YhfT; pfam10797
316401000017	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
316401000018	PS00627 GHMP kinases putative ATP-binding domain.
316401000019	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
316401000020	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
316401000021	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316401000022	catalytic residue [active]
316401000023	PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site.
316401000024	Protein of unknown function (DUF2502); Region: DUF2502; pfam10697
316401000025	Signal peptide predicted for ETEC0005 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 23 and 24
316401000026	1 probable transmembrane helix predicted for ETEC0005 by TMHMM2.0 at aa 7-29
316401000027	hypothetical protein; Validated; Region: PRK02101
316401000028	PS00225 Crystallins beta and gamma 'Greek key' motif signature.
316401000029	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
316401000030	Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235
316401000031	9 probable transmembrane helices predicted for ETEC0007 by TMHMM2.0 at aa 7-29, 78-100, 141-163, 178-199, 206-228, 300-322, 343-365, 385-407 and 414-436
316401000032	PS00873 Sodium:alanine symporter family signature.
316401000033	transaldolase-like protein; Provisional; Region: PTZ00411
316401000034	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
316401000035	active site
316401000036	dimer interface [polypeptide binding]; other site
316401000037	catalytic residue [active]
316401000038	PS01054 Transaldolase signature 1.
316401000039	PS00958 Transaldolase active site.
316401000040	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
316401000041	MPT binding site; other site
316401000042	trimer interface [polypeptide binding]; other site
316401000043	PS01078 Molybdenum cofactor biosynthesis proteins signature 1.
316401000044	hypothetical protein; Provisional; Region: PRK10659
316401000045	6 probable transmembrane helices predicted for ETEC0010 by TMHMM2.0 at aa 12-34, 38-57, 64-86, 96-118, 125-144 and 148-170
316401000046	PS01114 GPR1/FUN34/yaaH family signature.
316401000047	hypothetical protein; Provisional; Region: PRK10236
316401000048	Domain of unknown function (DUF3944); Region: DUF3944; pfam13099
316401000049	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735
316401000050	hypothetical protein; Provisional; Region: PRK10154
316401000051	Signal peptide predicted for ETEC0012 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.890 between residues 23 and 24
316401000052	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
316401000053	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
316401000054	nucleotide binding site [chemical binding]; other site
316401000055	NEF interaction site [polypeptide binding]; other site
316401000056	SBD interface [polypeptide binding]; other site
316401000057	PS00297 Heat shock hsp70 proteins family signature 1.
316401000058	PS00329 Heat shock hsp70 proteins family signature 2.
316401000059	PS01036 Heat shock hsp70 proteins family signature 3.
316401000060	chaperone protein DnaJ; Provisional; Region: PRK10767
316401000061	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
316401000062	HSP70 interaction site [polypeptide binding]; other site
316401000063	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
316401000064	substrate binding site [polypeptide binding]; other site
316401000065	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
316401000066	Zn binding sites [ion binding]; other site
316401000067	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
316401000068	dimer interface [polypeptide binding]; other site
316401000069	PS00636 Nt-dnaJ domain signature.
316401000070	PS00637 CXXCXGXG dnaJ domain signature.
316401000071	PS00190 Cytochrome c family heme-binding site signature.
316401000072	PS00190 Cytochrome c family heme-binding site signature.
316401000073	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
316401000074	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
316401000075	Hok/gef family; Region: HOK_GEF; pfam01848
316401000076	PS00556 Hok/gef family cell toxic proteins signature.
316401000077	1 probable transmembrane helix predicted for ETEC0016 by TMHMM2.0 at aa 25-44
316401000078	Signal peptide predicted for ETEC0016 by SignalP 2.0 HMM (Signal peptide probability 0.980) with cleavage site probability 0.931 between residues 40 and 41
316401000079	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561
316401000080	Signal peptide predicted for ETEC0017 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.578 between residues 33 and 34
316401000081	11 probable transmembrane helices predicted for ETEC0017 by TMHMM2.0 at aa 7-29, 59-76, 96-115, 125-147, 154-176, 180-202, 215-237, 257-279, 291-313, 328-350 and 357-379
316401000082	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
316401000083	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401000084	The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429
316401000085	putative dimerization interface [polypeptide binding]; other site
316401000086	PS00044 Bacterial regulatory proteins, lysR family signature.
316401000087	Signal peptide predicted for ETEC0020 by SignalP 2.0 HMM (Signal peptide probability 0.968) with cleavage site probability 0.867 between residues 18 and 19
316401000088	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
316401000089	PapC C-terminal domain; Region: PapC_C; pfam13953
316401000090	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
316401000091	Protein of unknown function (DUF2575); Region: DUF2575; pfam10837
316401000092	1 probable transmembrane helix predicted for ETEC0024 by TMHMM2.0 at aa 21-43
316401000093	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
316401000094	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
316401000095	active site
316401000096	Riboflavin kinase; Region: Flavokinase; smart00904
316401000097	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
316401000098	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
316401000099	HIGH motif; other site
316401000100	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
316401000101	active site
316401000102	KMSKS motif; other site
316401000103	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
316401000104	tRNA binding surface [nucleotide binding]; other site
316401000105	anticodon binding site; other site
316401000106	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
316401000107	PS00178 Aminoacyl-transfer RNA synthetases class-I signature.
316401000108	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
316401000109	4 probable transmembrane helices predicted for ETEC0027 by TMHMM2.0 at aa 13-35, 67-86, 99-121 and 136-158
316401000110	PS00855 Signal peptidases II signature.
316401000111	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
316401000112	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
316401000113	PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1.
316401000114	PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2.
316401000115	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
316401000116	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
316401000117	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
316401000118	active site
316401000119	tetramer interface [polypeptide binding]; other site
316401000120	PS01247 Inosine-uridine preferring nucleoside hydrolase family signature.
316401000121	PS00017 ATP/GTP-binding site motif A (P-loop).
316401000122	Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
316401000123	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
316401000124	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
316401000125	PS01298 Dihydrodipicolinate reductase signature.
316401000126	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
316401000127	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
316401000128	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
316401000129	catalytic site [active]
316401000130	subunit interface [polypeptide binding]; other site
316401000131	PS00442 Glutamine amidotransferases class-I active site.
316401000132	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
316401000133	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
316401000134	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
316401000135	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
316401000136	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
316401000137	ATP-grasp domain; Region: ATP-grasp_4; cl17255
316401000138	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
316401000139	IMP binding site; other site
316401000140	dimer interface [polypeptide binding]; other site
316401000141	interdomain contacts; other site
316401000142	partial ornithine binding site; other site
316401000143	Signal peptide predicted for ETEC0033 by SignalP 2.0 HMM (Signal peptide probability 0.643) with cleavage site probability 0.569 between residues 23 and 24
316401000144	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401000145	PS00866 Carbamoyl-phosphate synthase subdomain signature 1.
316401000146	PS00867 Carbamoyl-phosphate synthase subdomain signature 2.
316401000147	PS00866 Carbamoyl-phosphate synthase subdomain signature 1.
316401000148	PS00867 Carbamoyl-phosphate synthase subdomain signature 2.
316401000149	PS00017 ATP/GTP-binding site motif A (P-loop).
316401000150	DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476
316401000151	carnitine operon protein CaiE; Provisional; Region: PRK13627
316401000152	paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745
316401000153	putative trimer interface [polypeptide binding]; other site
316401000154	putative metal binding site [ion binding]; other site
316401000155	carnitinyl-CoA dehydratase; Provisional; Region: PRK03580
316401000156	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
316401000157	substrate binding site [chemical binding]; other site
316401000158	oxyanion hole (OAH) forming residues; other site
316401000159	trimer interface [polypeptide binding]; other site
316401000160	PS00166 Enoyl-CoA hydratase/isomerase signature.
316401000161	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
316401000162	putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008
316401000163	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934
316401000164	acyl-activating enzyme (AAE) consensus motif; other site
316401000165	putative AMP binding site [chemical binding]; other site
316401000166	putative active site [active]
316401000167	putative CoA binding site [chemical binding]; other site
316401000168	PS00455 Putative AMP-binding domain signature.
316401000169	crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525
316401000170	CoA-transferase family III; Region: CoA_transf_3; pfam02515
316401000171	crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354
316401000172	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
316401000173	active site
316401000174	PS00073 Acyl-CoA dehydrogenases signature 2.
316401000175	PS00072 Acyl-CoA dehydrogenases signature 1.
316401000176	L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356
316401000177	12 probable transmembrane helices predicted for ETEC0040 by TMHMM2.0 at aa 13-30, 50-72, 92-114, 141-163, 195-214, 229-251, 264-286, 317-339, 352-374, 410-432, 445-467 and 472-494
316401000178	PS01303 BCCT family of transporters signature.
316401000179	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
316401000180	Ligand binding site [chemical binding]; other site
316401000181	Electron transfer flavoprotein domain; Region: ETF; pfam01012
316401000182	PS01065 Electron transfer flavoprotein beta-subunit signature.
316401000183	putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363
316401000184	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985
316401000185	Ligand binding site [chemical binding]; other site
316401000186	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
316401000187	PS00696 Electron transfer flavoprotein alpha-subunit signature.
316401000188	putative oxidoreductase FixC; Provisional; Region: PRK10157
316401000189	ferredoxin-like protein FixX; Provisional; Region: PRK15449
316401000190	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401000191	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
316401000192	putative substrate translocation pore; other site
316401000193	12 probable transmembrane helices predicted for ETEC0045 by TMHMM2.0 at aa 19-41, 54-76, 85-104, 109-131, 144-166, 171-193, 244-266, 281-303, 310-329, 335-357, 370-392 and 402-421
316401000194	glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871
316401000195	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
316401000196	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
316401000197	TrkA-N domain; Region: TrkA_N; pfam02254
316401000198	13 probable transmembrane helices predicted for ETEC0047 by TMHMM2.0 at aa 5-24, 26-45, 55-72, 85-107, 112-134, 147-169, 179-201, 214-233, 237-254, 267-289, 293-315, 327-349 and 359-381
316401000199	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
316401000200	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
316401000201	folate binding site [chemical binding]; other site
316401000202	NADP+ binding site [chemical binding]; other site
316401000203	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
316401000204	PS00075 Dihydrofolate reductase signature.
316401000205	bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668
316401000206	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
316401000207	active site
316401000208	metal binding site [ion binding]; metal-binding site
316401000209	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
316401000210	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
316401000211	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
316401000212	PS01131 Ribosomal RNA adenine dimethylases signature.
316401000213	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
316401000214	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
316401000215	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
316401000216	SurA N-terminal domain; Region: SurA_N; pfam09312
316401000217	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
316401000218	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
316401000219	PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature.
316401000220	PS00017 ATP/GTP-binding site motif A (P-loop).
316401000221	PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature.
316401000222	Signal peptide predicted for ETEC0053 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 20 and 21
316401000223	LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761
316401000224	OstA-like protein; Region: OstA; pfam03968
316401000225	Organic solvent tolerance protein; Region: OstA_C; pfam04453
316401000226	Signal peptide predicted for ETEC0054 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 24 and 25
316401000227	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
316401000228	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
316401000229	putative metal binding site [ion binding]; other site
316401000230	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
316401000231	HSP70 interaction site [polypeptide binding]; other site
316401000232	1 probable transmembrane helix predicted for ETEC0055 by TMHMM2.0 at aa 7-29
316401000233	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
316401000234	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
316401000235	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
316401000236	active site
316401000237	PS01129 Rlu family of pseudouridine synthase signature.
316401000238	ATP-dependent helicase HepA; Validated; Region: PRK04914
316401000239	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
316401000240	ATP binding site [chemical binding]; other site
316401000241	putative Mg++ binding site [ion binding]; other site
316401000242	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
316401000243	nucleotide binding region [chemical binding]; other site
316401000244	ATP-binding site [chemical binding]; other site
316401000245	DNA polymerase II; Reviewed; Region: PRK05762
316401000246	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784
316401000247	active site
316401000248	catalytic site [active]
316401000249	substrate binding site [chemical binding]; other site
316401000250	DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
316401000251	active site
316401000252	metal-binding site
316401000253	PS00116 DNA polymerase family B signature.
316401000254	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
316401000255	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
316401000256	intersubunit interface [polypeptide binding]; other site
316401000257	active site
316401000258	Zn2+ binding site [ion binding]; other site
316401000259	L-arabinose isomerase; Provisional; Region: PRK02929
316401000260	L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557
316401000261	putative hexamer (dimer of trimers) interface [polypeptide binding]; other site
316401000262	trimer interface [polypeptide binding]; other site
316401000263	putative substrate binding site [chemical binding]; other site
316401000264	putative metal binding site [ion binding]; other site
316401000265	ribulokinase; Provisional; Region: PRK04123
316401000266	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
316401000267	N- and C-terminal domain interface [polypeptide binding]; other site
316401000268	active site
316401000269	MgATP binding site [chemical binding]; other site
316401000270	catalytic site [active]
316401000271	metal binding site [ion binding]; metal-binding site
316401000272	carbohydrate binding site [chemical binding]; other site
316401000273	homodimer interface [polypeptide binding]; other site
316401000274	DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572
316401000275	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
316401000276	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316401000277	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316401000278	PS00041 Bacterial regulatory proteins, araC family signature.
316401000279	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
316401000280	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
316401000281	5 probable transmembrane helices predicted for ETEC0064 by TMHMM2.0 at aa 20-42, 57-79, 147-169, 179-196 and 217-236
316401000282	thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771
316401000283	ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298
316401000284	Walker A/P-loop; other site
316401000285	ATP binding site [chemical binding]; other site
316401000286	Q-loop/lid; other site
316401000287	ABC transporter signature motif; other site
316401000288	Walker B; other site
316401000289	D-loop; other site
316401000290	H-loop/switch region; other site
316401000291	PS00211 ABC transporters family signature.
316401000292	PS00017 ATP/GTP-binding site motif A (P-loop).
316401000293	thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433
316401000294	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401000295	dimer interface [polypeptide binding]; other site
316401000296	conserved gate region; other site
316401000297	putative PBP binding loops; other site
316401000298	ABC-ATPase subunit interface; other site
316401000299	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401000300	dimer interface [polypeptide binding]; other site
316401000301	conserved gate region; other site
316401000302	putative PBP binding loops; other site
316401000303	ABC-ATPase subunit interface; other site
316401000304	12 probable transmembrane helices predicted for ETEC0066 by TMHMM2.0 at aa 13-35, 55-77, 90-112, 132-151, 199-221, 241-260, 293-315, 335-357, 370-392, 407-424, 462-484 and 508-525
316401000305	Signal peptide predicted for ETEC0066 by SignalP 2.0 HMM (Signal peptide probability 0.856) with cleavage site probability 0.598 between residues 29 and 30
316401000306	thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205
316401000307	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
316401000308	PS01037 Bacterial extracellular solute-binding proteins, family 1 signature.
316401000309	Signal peptide predicted for ETEC0067 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 18 and 19
316401000310	transcriptional regulator SgrR; Provisional; Region: PRK13626
316401000311	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
316401000312	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
316401000313	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401000314	sugar efflux transporter; Region: 2A0120; TIGR00899
316401000315	putative substrate translocation pore; other site
316401000316	Signal peptide predicted for ETEC0069 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.666 between residues 30 and 31
316401000317	12 probable transmembrane helices predicted for ETEC0069 by TMHMM2.0 at aa 13-35, 50-69, 82-99, 104-126, 150-172, 176-198, 220-242, 252-274, 283-302, 307-329, 342-364 and 369-387
316401000318	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
316401000319	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
316401000320	substrate binding site [chemical binding]; other site
316401000321	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
316401000322	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
316401000323	substrate binding site [chemical binding]; other site
316401000324	ligand binding site [chemical binding]; other site
316401000325	PS01244 Aconitase family signature 2.
316401000326	PS00450 Aconitase family signature 1.
316401000327	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
316401000328	tartrate dehydrogenase; Region: TTC; TIGR02089
316401000329	PS00470 Isocitrate and isopropylmalate dehydrogenases signature.
316401000330	2-isopropylmalate synthase; Validated; Region: PRK00915
316401000331	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
316401000332	active site
316401000333	catalytic residues [active]
316401000334	metal binding site [ion binding]; metal-binding site
316401000335	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
316401000336	PS00816 Alpha-isopropylmalate and homocitrate synthases signature 2.
316401000337	PS00815 Alpha-isopropylmalate and homocitrate synthases signature 1.
316401000338	leu operon leader peptide; Provisional; Region: PRK09925
316401000339	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
316401000340	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401000341	The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466
316401000342	putative substrate binding pocket [chemical binding]; other site
316401000343	putative dimerization interface [polypeptide binding]; other site
316401000344	PS00044 Bacterial regulatory proteins, lysR family signature.
316401000345	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
316401000346	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979
316401000347	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
316401000348	PYR/PP interface [polypeptide binding]; other site
316401000349	dimer interface [polypeptide binding]; other site
316401000350	TPP binding site [chemical binding]; other site
316401000351	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
316401000352	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
316401000353	TPP-binding site [chemical binding]; other site
316401000354	dimer interface [polypeptide binding]; other site
316401000355	PS00044 Bacterial regulatory proteins, lysR family signature.
316401000356	PS00187 Thiamine pyrophosphate enzymes signature.
316401000357	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
316401000358	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
316401000359	putative valine binding site [chemical binding]; other site
316401000360	dimer interface [polypeptide binding]; other site
316401000361	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
316401000362	PS00430 TonB-dependent receptor proteins signature 1.
316401000363	DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303
316401000364	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
316401000365	DNA binding site [nucleotide binding]
316401000366	domain linker motif; other site
316401000367	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
316401000368	dimerization interface [polypeptide binding]; other site
316401000369	ligand binding site [chemical binding]; other site
316401000370	PS00356 Bacterial regulatory proteins, lacI family signature.
316401000371	mraZ protein; Region: TIGR00242
316401000372	MraZ protein; Region: MraZ; pfam02381
316401000373	MraZ protein; Region: MraZ; pfam02381
316401000374	16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006
316401000375	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
316401000376	cell division protein FtsL; Provisional; Region: PRK10772
316401000377	1 probable transmembrane helix predicted for ETEC0081 by TMHMM2.0 at aa 35-57
316401000378	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
316401000379	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
316401000380	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
316401000381	Signal peptide predicted for ETEC0082 by SignalP 2.0 HMM (Signal peptide probability 0.938) with cleavage site probability 0.446 between residues 45 and 46
316401000382	1 probable transmembrane helix predicted for ETEC0082 by TMHMM2.0 at aa 21-43
316401000383	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
316401000384	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
316401000385	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
316401000386	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
316401000387	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773
316401000388	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
316401000389	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
316401000390	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
316401000391	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
316401000392	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
316401000393	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
316401000394	Mg++ binding site [ion binding]; other site
316401000395	putative catalytic motif [active]
316401000396	putative substrate binding site [chemical binding]; other site
316401000397	10 probable transmembrane helices predicted for ETEC0085 by TMHMM2.0 at aa 15-37, 75-92, 97-114, 134-151, 171-193, 200-219, 234-256, 263-285, 289-311 and 338-357
316401000398	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806
316401000399	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
316401000400	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
316401000401	1 probable transmembrane helix predicted for ETEC0086 by TMHMM2.0 at aa 9-31
316401000402	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401000403	PS00012 Phosphopantetheine attachment site.
316401000404	cell division protein FtsW; Provisional; Region: PRK10774
316401000405	10 probable transmembrane helices predicted for ETEC0087 by TMHMM2.0 at aa 13-32, 47-66, 86-105, 110-132, 175-194, 198-217, 222-244, 307-329, 341-363 and 373-395
316401000406	PS00428 Cell cycle proteins ftsW / rodA / spoVE signature.
316401000407	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
316401000408	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
316401000409	active site
316401000410	homodimer interface [polypeptide binding]; other site
316401000411	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
316401000412	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
316401000413	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
316401000414	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
316401000415	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
316401000416	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
316401000417	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
316401000418	PS00843 D-alanine--D-alanine ligase signature 1.
316401000419	PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide.
316401000420	PS00844 D-alanine--D-alanine ligase signature 2.
316401000421	cell division protein FtsQ; Provisional; Region: PRK10775
316401000422	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
316401000423	Cell division protein FtsQ; Region: FtsQ; pfam03799
316401000424	1 probable transmembrane helix predicted for ETEC0091 by TMHMM2.0 at aa 25-47
316401000425	cell division protein FtsA; Reviewed; Region: ftsA; PRK09472
316401000426	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
316401000427	Cell division protein FtsA; Region: FtsA; pfam14450
316401000428	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401000429	cell division protein FtsZ; Validated; Region: PRK09330
316401000430	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
316401000431	nucleotide binding site [chemical binding]; other site
316401000432	SulA interaction site; other site
316401000433	PS01134 FtsZ protein signature 1.
316401000434	PS01135 FtsZ protein signature 2.
316401000435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
316401000436	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
316401000437	SecA regulator SecM; Provisional; Region: PRK02943
316401000438	Signal peptide predicted for ETEC0095 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.990 between residues 37 and 38
316401000439	1 probable transmembrane helix predicted for ETEC0095 by TMHMM2.0 at aa 15-37
316401000440	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
316401000441	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
316401000442	SEC-C motif; Region: SEC-C; pfam02810
316401000443	PS01312 Protein secA signatures.
316401000444	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
316401000445	active site
316401000446	8-oxo-dGMP binding site [chemical binding]; other site
316401000447	nudix motif; other site
316401000448	metal binding site [ion binding]; metal-binding site
316401000449	PS00893 mutT domain signature.
316401000450	DNA gyrase inhibitor; Reviewed; Region: PRK00418
316401000451	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582
316401000452	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
316401000453	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
316401000454	CoA-binding site [chemical binding]; other site
316401000455	ATP-binding [chemical binding]; other site
316401000456	PS01294 Uncharacterized protein family UPF0038 signature.
316401000457	PS00017 ATP/GTP-binding site motif A (P-loop).
316401000458	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096
316401000459	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
316401000460	active site
316401000461	PS00487 IMP dehydrogenase / GMP reductase signature.
316401000462	type IV pilin biogenesis protein; Provisional; Region: PRK10573
316401000463	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
316401000464	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
316401000465	3 probable transmembrane helices predicted for ETEC0102 by TMHMM2.0 at aa 163-185, 216-235 and 368-390
316401000466	PS00874 Bacterial type II secretion system protein F signature.
316401000467	hypothetical protein; Provisional; Region: PRK10436
316401000468	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
316401000469	Walker A motif; other site
316401000470	ATP binding site [chemical binding]; other site
316401000471	Walker B motif; other site
316401000472	PS00662 Bacterial type II secretion system protein E signature.
316401000473	PS00017 ATP/GTP-binding site motif A (P-loop).
316401000474	putative major pilin subunit; Provisional; Region: PRK10574
316401000475	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
316401000476	Pilin (bacterial filament); Region: Pilin; pfam00114
316401000477	1 probable transmembrane helix predicted for ETEC0104 by TMHMM2.0 at aa 7-29
316401000478	PS00409 Prokaryotic N-terminal methylation site.
316401000479	quinolinate phosphoribosyltransferase; Validated; Region: PRK09016
316401000480	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
316401000481	dimerization interface [polypeptide binding]; other site
316401000482	active site
316401000483	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
316401000484	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
316401000485	amidase catalytic site [active]
316401000486	Zn binding residues [ion binding]; other site
316401000487	substrate binding site [chemical binding]; other site
316401000488	regulatory protein AmpE; Provisional; Region: PRK10987
316401000489	4 probable transmembrane helices predicted for ETEC0107 by TMHMM2.0 at aa 39-58, 63-85, 146-168 and 266-283
316401000490	aromatic amino acid transporter; Provisional; Region: PRK10238
316401000491	12 probable transmembrane helices predicted for ETEC0108 by TMHMM2.0 at aa 20-42, 47-66, 87-109, 119-141, 154-176, 199-221, 241-263, 283-305, 332-354, 358-380, 400-422 and 427-446
316401000492	PS00218 Amino acid permeases signature.
316401000493	Transcriptional regulators [Transcription]; Region: FadR; COG2186
316401000494	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
316401000495	DNA-binding site [nucleotide binding]; DNA binding site
316401000496	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
316401000497	PS00043 Bacterial regulatory proteins, gntR family signature.
316401000498	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
316401000499	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
316401000500	dimer interface [polypeptide binding]; other site
316401000501	TPP-binding site [chemical binding]; other site
316401000502	pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
316401000503	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
316401000504	E3 interaction surface; other site
316401000505	lipoyl attachment site [posttranslational modification]; other site
316401000506	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
316401000507	E3 interaction surface; other site
316401000508	lipoyl attachment site [posttranslational modification]; other site
316401000509	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
316401000510	E3 interaction surface; other site
316401000511	lipoyl attachment site [posttranslational modification]; other site
316401000512	e3 binding domain; Region: E3_binding; pfam02817
316401000513	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
316401000514	PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site.
316401000515	PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site.
316401000516	PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site.
316401000517	PS00017 ATP/GTP-binding site motif A (P-loop).
316401000518	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
316401000519	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
316401000520	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
316401000521	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
316401000522	PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site.
316401000523	Protein of unknown function (DUF3300); Region: DUF3300; pfam11737
316401000524	Protein of unknown function (DUF3106); Region: DUF3106; pfam11304
316401000525	Signal peptide predicted for ETEC0113 by SignalP 2.0 HMM (Signal peptide probability 0.985) with cleavage site probability 0.428 between residues 23 and 24
316401000526	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
316401000527	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
316401000528	substrate binding site [chemical binding]; other site
316401000529	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
316401000530	substrate binding site [chemical binding]; other site
316401000531	ligand binding site [chemical binding]; other site
316401000532	PS00450 Aconitase family signature 1.
316401000533	PS01244 Aconitase family signature 2.
316401000534	hypothetical protein; Provisional; Region: PRK05248
316401000535	S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462
316401000536	spermidine synthase; Provisional; Region: PRK00811
316401000537	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316401000538	S-adenosylmethionine binding site [chemical binding]; other site
316401000539	PS01330 Spermidine/spermine synthases family signature.
316401000540	Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898
316401000541	Signal peptide predicted for ETEC0118 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.563 between residues 24 and 25
316401000542	multicopper oxidase; Provisional; Region: PRK10965
316401000543	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
316401000544	Multicopper oxidase; Region: Cu-oxidase; pfam00394
316401000545	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
316401000546	Signal peptide predicted for ETEC0119 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 28 and 29
316401000547	PS00080 Multicopper oxidases signature 2.
316401000548	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
316401000549	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
316401000550	Trp docking motif [polypeptide binding]; other site
316401000551	putative active site [active]
316401000552	PS00364 Bacterial quinoprotein dehydrogenases signature 2.
316401000553	PS00363 Bacterial quinoprotein dehydrogenases signature 1.
316401000554	5 probable transmembrane helices predicted for ETEC0120 by TMHMM2.0 at aa 13-35, 40-57, 64-81, 96-114 and 121-140
316401000555	Signal peptide predicted for ETEC0120 by SignalP 2.0 HMM (Signal peptide probability 0.726) with cleavage site probability 0.395 between residues 38 and 39
316401000556	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
316401000557	active site
316401000558	PS00103 Purine/pyrimidine phosphoribosyl transferases signature.
316401000559	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
316401000560	active site clefts [active]
316401000561	zinc binding site [ion binding]; other site
316401000562	dimer interface [polypeptide binding]; other site
316401000563	PS00705 Prokaryotic-type carbonic anhydrases signature 2.
316401000564	PS00704 Prokaryotic-type carbonic anhydrases signature 1.
316401000565	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
316401000566	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
316401000567	Walker A/P-loop; other site
316401000568	ATP binding site [chemical binding]; other site
316401000569	Q-loop/lid; other site
316401000570	ABC transporter signature motif; other site
316401000571	Walker B; other site
316401000572	D-loop; other site
316401000573	H-loop/switch region; other site
316401000574	PS00017 ATP/GTP-binding site motif A (P-loop).
316401000575	PS00211 ABC transporters family signature.
316401000576	inner membrane transport permease; Provisional; Region: PRK15066
316401000577	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
316401000578	6 probable transmembrane helices predicted for ETEC0124 by TMHMM2.0 at aa 20-42, 62-84, 104-126, 141-163, 170-192 and 226-248
316401000579	PS00890 ABC-2 type transport system integral membrane proteins signature.
316401000580	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
316401000581	active pocket/dimerization site; other site
316401000582	active site
316401000583	phosphorylation site [posttranslational modification]
316401000584	Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966
316401000585	putative active site [active]
316401000586	putative metal binding site [ion binding]; other site
316401000587	Signal peptide predicted for ETEC0126 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.942 between residues 19 and 20
316401000588	1 probable transmembrane helix predicted for ETEC0126 by TMHMM2.0 at aa 5-23
316401000589	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
316401000590	tetramerization interface [polypeptide binding]; other site
316401000591	active site
316401000592	PS00678 Trp-Asp (WD) repeats signature.
316401000593	Uncharacterized conserved protein [Function unknown]; Region: COG5464
316401000594	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
316401000595	pantoate--beta-alanine ligase; Region: panC; TIGR00018
316401000596	Pantoate-beta-alanine ligase; Region: PanC; cd00560
316401000597	active site
316401000598	ATP-binding site [chemical binding]; other site
316401000599	pantoate-binding site; other site
316401000600	HXXH motif; other site
316401000601	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
316401000602	oligomerization interface [polypeptide binding]; other site
316401000603	active site
316401000604	metal binding site [ion binding]; metal-binding site
316401000605	putative fimbrial-like adhesin protein; Provisional; Region: PRK09723
316401000606	1 probable transmembrane helix predicted for ETEC0131 by TMHMM2.0 at aa 7-29
316401000607	Signal peptide predicted for ETEC0131 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.978 between residues 22 and 23
316401000608	putative fimbrial protein StaF; Provisional; Region: PRK15262
316401000609	1 probable transmembrane helix predicted for ETEC0132 by TMHMM2.0 at aa 12-29
316401000610	Signal peptide predicted for ETEC0132 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.965 between residues 28 and 29
316401000611	putative fimbrial protein StaE; Provisional; Region: PRK15263
316401000612	1 probable transmembrane helix predicted for ETEC0133 by TMHMM2.0 at aa 7-29
316401000613	Signal peptide predicted for ETEC0133 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 28 and 29
316401000614	Fimbrial protein; Region: Fimbrial; cl01416
316401000615	Signal peptide predicted for ETEC0134 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 23 and 24
316401000616	putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828
316401000617	PapC N-terminal domain; Region: PapC_N; pfam13954
316401000618	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
316401000619	PapC C-terminal domain; Region: PapC_C; pfam13953
316401000620	PS01151 Fimbrial biogenesis outer membrane usher protein signature.
316401000621	Signal peptide predicted for ETEC0135 by SignalP 2.0 HMM (Signal peptide probability 0.980) with cleavage site probability 0.978 between residues 29 and 30
316401000622	putative chaperone protein EcpD; Provisional; Region: PRK09926
316401000623	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
316401000624	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
316401000625	PS00635 Gram-negative pili assembly chaperone signature.
316401000626	Signal peptide predicted for ETEC0136 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 25 and 26
316401000627	Fimbrial protein; Region: Fimbrial; cl01416
316401000628	Signal peptide predicted for ETEC0137 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.988 between residues 23 and 24
316401000629	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
316401000630	catalytic center binding site [active]
316401000631	ATP binding site [chemical binding]; other site
316401000632	PS00794 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature.
316401000633	poly(A) polymerase I; Provisional; Region: pcnB; PRK11623
316401000634	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
316401000635	active site
316401000636	NTP binding site [chemical binding]; other site
316401000637	metal binding triad [ion binding]; metal-binding site
316401000638	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
316401000639	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
316401000640	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
316401000641	tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749
316401000642	active site
316401000643	nucleotide binding site [chemical binding]; other site
316401000644	HIGH motif; other site
316401000645	KMSKS motif; other site
316401000646	RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778
316401000647	PS01102 Prokaryotic dksA/traR C4-type zinc finger.
316401000648	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
316401000649	2'-5' RNA ligase; Provisional; Region: PRK15124
316401000650	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
316401000651	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
316401000652	ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664
316401000653	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
316401000654	ATP binding site [chemical binding]; other site
316401000655	putative Mg++ binding site [ion binding]; other site
316401000656	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
316401000657	nucleotide binding region [chemical binding]; other site
316401000658	ATP-binding site [chemical binding]; other site
316401000659	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847
316401000660	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
316401000661	PS00017 ATP/GTP-binding site motif A (P-loop).
316401000662	PS00904 Protein prenyltransferases alpha subunit repeat signature.
316401000663	bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506
316401000664	Transglycosylase; Region: Transgly; pfam00912
316401000665	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
316401000666	1 probable transmembrane helix predicted for ETEC0145 by TMHMM2.0 at aa 65-87
316401000667	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
316401000668	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
316401000669	N-terminal plug; other site
316401000670	ligand-binding site [chemical binding]; other site
316401000671	PS00430 TonB-dependent receptor proteins signature 1.
316401000672	Signal peptide predicted for ETEC0146 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.971 between residues 33 and 34
316401000673	PS01156 TonB-dependent receptor proteins signature 2.
316401000674	iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575
316401000675	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
316401000676	Walker A/P-loop; other site
316401000677	ATP binding site [chemical binding]; other site
316401000678	Q-loop/lid; other site
316401000679	ABC transporter signature motif; other site
316401000680	Walker B; other site
316401000681	D-loop; other site
316401000682	H-loop/switch region; other site
316401000683	PS00017 ATP/GTP-binding site motif A (P-loop).
316401000684	PS00211 ABC transporters family signature.
316401000685	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
316401000686	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
316401000687	siderophore binding site; other site
316401000688	Signal peptide predicted for ETEC0148 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 30 and 31
316401000689	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
316401000690	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
316401000691	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
316401000692	ABC-ATPase subunit  interface; other site
316401000693	dimer interface [polypeptide binding]; other site
316401000694	putative PBP binding regions; other site
316401000695	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
316401000696	ABC-ATPase subunit  interface; other site
316401000697	dimer interface [polypeptide binding]; other site
316401000698	putative PBP binding regions; other site
316401000699	Signal peptide predicted for ETEC0149 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.667 between residues 31 and 32
316401000700	17 probable transmembrane helices predicted for ETEC0149 by TMHMM2.0 at aa 7-29, 57-79, 92-111, 115-137, 144-166, 239-261, 273-291, 301-323, 347-369, 389-411, 424-442, 446-468, 480-499, 525-547, 568-590, 605-624 and 631-653
316401000701	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
316401000702	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
316401000703	inhibitor-cofactor binding pocket; inhibition site
316401000704	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316401000705	catalytic residue [active]
316401000706	PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site.
316401000707	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
316401000708	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
316401000709	Cl- selectivity filter; other site
316401000710	Cl- binding residues [ion binding]; other site
316401000711	pore gating glutamate residue; other site
316401000712	dimer interface [polypeptide binding]; other site
316401000713	H+/Cl- coupling transport residue; other site
316401000714	Signal peptide predicted for ETEC0151 by SignalP 2.0 HMM (Signal peptide probability 0.677) with cleavage site probability 0.485 between residues 52 and 53
316401000715	11 probable transmembrane helices predicted for ETEC0151 by TMHMM2.0 at aa 31-53, 75-97, 124-146, 179-201, 210-232, 252-274, 287-309, 319-341, 354-376, 391-413 and 418-440
316401000716	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
316401000717	PS01152 Hypothetical hesB/yadR/yfhF family signature.
316401000718	hypothetical protein; Provisional; Region: PRK10578
316401000719	UPF0126 domain; Region: UPF0126; pfam03458
316401000720	UPF0126 domain; Region: UPF0126; pfam03458
316401000721	7 probable transmembrane helices predicted for ETEC0153 by TMHMM2.0 at aa 4-23, 30-47, 62-79, 88-105, 115-137, 149-168 and 172-191
316401000722	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
316401000723	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
316401000724	cobalamin binding residues [chemical binding]; other site
316401000725	putative BtuC binding residues; other site
316401000726	dimer interface [polypeptide binding]; other site
316401000727	Signal peptide predicted for ETEC0154 by SignalP 2.0 HMM (Signal peptide probability 0.990) with cleavage site probability 0.963 between residues 22 and 23
316401000728	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
316401000729	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
316401000730	deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926
316401000731	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
316401000732	Zn2+ binding site [ion binding]; other site
316401000733	Mg2+ binding site [ion binding]; other site
316401000734	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
316401000735	serine endoprotease; Provisional; Region: PRK10942
316401000736	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
316401000737	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
316401000738	protein binding site [polypeptide binding]; other site
316401000739	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
316401000740	Signal peptide predicted for ETEC0157 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 26 and 27
316401000741	carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477
316401000742	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
316401000743	hypothetical protein; Provisional; Region: PRK13677
316401000744	phosphodiesterase YaeI; Provisional; Region: PRK11340
316401000745	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
316401000746	putative active site [active]
316401000747	putative metal binding site [ion binding]; other site
316401000748	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
316401000749	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
316401000750	trimer interface [polypeptide binding]; other site
316401000751	active site
316401000752	substrate binding site [chemical binding]; other site
316401000753	CoA binding site [chemical binding]; other site
316401000754	PS00101 Hexapeptide-repeat containing-transferases signature.
316401000755	PII uridylyl-transferase; Provisional; Region: PRK05007
316401000756	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
316401000757	metal binding triad; other site
316401000758	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
316401000759	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
316401000760	Zn2+ binding site [ion binding]; other site
316401000761	Mg2+ binding site [ion binding]; other site
316401000762	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
316401000763	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
316401000764	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
316401000765	active site
316401000766	PS00680 Methionine aminopeptidase subfamily 1 signature.
316401000767	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
316401000768	rRNA interaction site [nucleotide binding]; other site
316401000769	S8 interaction site; other site
316401000770	putative laminin-1 binding site; other site
316401000771	PS00962 Ribosomal protein S2 signature 1.
316401000772	PS00963 Ribosomal protein S2 signature 2.
316401000773	elongation factor Ts; Provisional; Region: tsf; PRK09377
316401000774	UBA/TS-N domain; Region: UBA; pfam00627
316401000775	Elongation factor TS; Region: EF_TS; pfam00889
316401000776	Elongation factor TS; Region: EF_TS; pfam00889
316401000777	PS01126 Elongation factor Ts signature 1.
316401000778	PS01127 Elongation factor Ts signature 2.
316401000779	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
316401000780	putative nucleotide binding site [chemical binding]; other site
316401000781	uridine monophosphate binding site [chemical binding]; other site
316401000782	homohexameric interface [polypeptide binding]; other site
316401000783	ribosome recycling factor; Reviewed; Region: frr; PRK00083
316401000784	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
316401000785	hinge region; other site
316401000786	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
316401000787	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
316401000788	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
316401000789	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
316401000790	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401000791	PS00017 ATP/GTP-binding site motif A (P-loop).
316401000792	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
316401000793	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
316401000794	catalytic residue [active]
316401000795	putative FPP diphosphate  binding site; other site
316401000796	putative FPP binding hydrophobic cleft; other site
316401000797	dimer interface [polypeptide binding]; other site
316401000798	putative IPP diphosphate binding site; other site
316401000799	PS01066 Undecaprenyl pyrophosphate synthetase family signature.
316401000800	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
316401000801	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
316401000802	Signal peptide predicted for ETEC0170 by SignalP 2.0 HMM (Signal peptide probability 0.948) with cleavage site probability 0.763 between residues 29 and 30
316401000803	8 probable transmembrane helices predicted for ETEC0170 by TMHMM2.0 at aa 7-41, 56-74, 87-106, 121-143, 150-172, 192-211, 218-240 and 260-282
316401000804	PS01315 Phosphatidate cytidylyltransferase signature.
316401000805	zinc metallopeptidase RseP; Provisional; Region: PRK10779
316401000806	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
316401000807	active site
316401000808	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
316401000809	protein binding site [polypeptide binding]; other site
316401000810	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
316401000811	putative substrate binding region [chemical binding]; other site
316401000812	4 probable transmembrane helices predicted for ETEC0171 by TMHMM2.0 at aa 2-21, 98-120, 376-398 and 426-445
316401000813	PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.
316401000814	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
316401000815	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
316401000816	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
316401000817	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
316401000818	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
316401000819	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
316401000820	Surface antigen; Region: Bac_surface_Ag; pfam01103
316401000821	Signal peptide predicted for ETEC0172 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.980 between residues 20 and 21
316401000822	periplasmic chaperone; Provisional; Region: PRK10780
316401000823	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
316401000824	Signal peptide predicted for ETEC0173 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 20 and 21
316401000825	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
316401000826	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
316401000827	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
316401000828	trimer interface [polypeptide binding]; other site
316401000829	active site
316401000830	UDP-GlcNAc binding site [chemical binding]; other site
316401000831	lipid binding site [chemical binding]; lipid-binding site
316401000832	PS00101 Hexapeptide-repeat containing-transferases signature.
316401000833	PS00101 Hexapeptide-repeat containing-transferases signature.
316401000834	PS00101 Hexapeptide-repeat containing-transferases signature.
316401000835	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
316401000836	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
316401000837	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
316401000838	active site
316401000839	PS00101 Hexapeptide-repeat containing-transferases signature.
316401000840	PS00101 Hexapeptide-repeat containing-transferases signature.
316401000841	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
316401000842	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
316401000843	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
316401000844	RNA/DNA hybrid binding site [nucleotide binding]; other site
316401000845	active site
316401000846	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
316401000847	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
316401000848	putative active site [active]
316401000849	putative PHP Thumb interface [polypeptide binding]; other site
316401000850	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
316401000851	generic binding surface II; other site
316401000852	generic binding surface I; other site
316401000853	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
316401000854	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
316401000855	lysine decarboxylase LdcC; Provisional; Region: PRK15399
316401000856	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
316401000857	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
316401000858	homodimer interface [polypeptide binding]; other site
316401000859	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316401000860	catalytic residue [active]
316401000861	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
316401000862	PS00703 Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site.
316401000863	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
316401000864	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
316401000865	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
316401000866	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
316401000867	Ligand Binding Site [chemical binding]; other site
316401000868	TilS substrate binding domain; Region: TilS; pfam09179
316401000869	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
316401000870	Rho-binding antiterminator; Provisional; Region: PRK11625
316401000871	hypothetical protein; Provisional; Region: PRK04964
316401000872	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681
316401000873	hypothetical protein; Provisional; Region: PRK09256
316401000874	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
316401000875	PS00745 Prokaryotic-type class I peptide chain release factors signature.
316401000876	lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523
316401000877	NlpE N-terminal domain; Region: NlpE; pfam04170
316401000878	Signal peptide predicted for ETEC0188 by SignalP 2.0 HMM (Signal peptide probability 0.969) with cleavage site probability 0.613 between residues 25 and 26
316401000879	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401000880	PS00283 Soybean trypsin inhibitor (Kunitz) protease inhibitors family signature.
316401000882	prolyl-tRNA synthetase; Provisional; Region: PRK09194
316401000883	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
316401000884	dimer interface [polypeptide binding]; other site
316401000885	motif 1; other site
316401000886	active site
316401000887	motif 2; other site
316401000888	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
316401000889	putative deacylase active site [active]
316401000890	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
316401000891	active site
316401000892	motif 3; other site
316401000893	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
316401000894	anticodon binding site; other site
316401000895	PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1.
316401000896	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
316401000897	homodimer interaction site [polypeptide binding]; other site
316401000898	cofactor binding site; other site
316401000899	PS01318 Uncharacterized protein family UPF0066 signature.
316401000900	outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781
316401000901	Signal peptide predicted for ETEC0192 by SignalP 2.0 HMM (Signal peptide probability 0.718) with cleavage site probability 0.623 between residues 19 and 20
316401000902	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401000903	DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063
316401000904	lipoprotein, YaeC family; Region: TIGR00363
316401000905	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401000906	Signal peptide predicted for ETEC0193 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.719 between residues 22 and 23
316401000907	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401000908	dimer interface [polypeptide binding]; other site
316401000909	conserved gate region; other site
316401000910	ABC-ATPase subunit interface; other site
316401000911	5 probable transmembrane helices predicted for ETEC0194 by TMHMM2.0 at aa 18-40, 60-78, 82-104, 144-166 and 181-203
316401000912	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
316401000913	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
316401000914	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
316401000915	Walker A/P-loop; other site
316401000916	ATP binding site [chemical binding]; other site
316401000917	Q-loop/lid; other site
316401000918	ABC transporter signature motif; other site
316401000919	Walker B; other site
316401000920	D-loop; other site
316401000921	H-loop/switch region; other site
316401000922	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
316401000923	PS00211 ABC transporters family signature.
316401000924	PS00017 ATP/GTP-binding site motif A (P-loop).
316401000925	D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213
316401000926	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
316401000927	active site
316401000928	motif I; other site
316401000929	motif II; other site
316401000930	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
316401000931	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
316401000932	active site
316401000933	catalytic tetrad [active]
316401000934	PS00798 Aldo/keto reductase family signature 1.
316401000935	Transcriptional regulator [Transcription]; Region: LysR; COG0583
316401000936	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401000937	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478
316401000938	putative effector binding pocket; other site
316401000939	dimerization interface [polypeptide binding]; other site
316401000940	PS00044 Bacterial regulatory proteins, lysR family signature.
316401000941	hypothetical protein; Provisional; Region: PRK05421
316401000942	putative catalytic site [active]
316401000943	putative metal binding site [ion binding]; other site
316401000944	putative phosphate binding site [ion binding]; other site
316401000945	putative catalytic site [active]
316401000946	putative phosphate binding site [ion binding]; other site
316401000947	putative metal binding site [ion binding]; other site
316401000948	Methyltransferase domain; Region: Methyltransf_31; pfam13847
316401000949	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316401000950	S-adenosylmethionine binding site [chemical binding]; other site
316401000951	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
316401000952	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
316401000953	N-acetyl-D-glucosamine binding site [chemical binding]; other site
316401000954	catalytic residue [active]
316401000955	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
316401000956	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
316401000957	PS00922 Prokaryotic transglycosylases signature.
316401000958	Signal peptide predicted for ETEC0201 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.538 between residues 26 and 27
316401000959	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401000960	hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241
316401000961	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316401000962	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
316401000963	RNA/DNA hybrid binding site [nucleotide binding]; other site
316401000964	active site
316401000965	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
316401000966	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
316401000967	active site
316401000968	catalytic site [active]
316401000969	substrate binding site [chemical binding]; other site
316401000970	Methyltransferase domain; Region: Methyltransf_27; pfam13708
316401000971	Methyltransferase domain; Region: Methyltransf_27; pfam13708
316401000972	Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117
316401000973	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
316401000974	catalytic residue [active]
316401000975	Protein of unknown function (DUF1219); Region: DUF1219; pfam06755
316401000976	Similar to Escherichia coli B IS1 transposase. UniProt:A2ULP6 (125 aa) fasta scores: E()=1.1e-46, 98.400% id in 125 aa, and to Shigella boydii serotype 4 (strain sb227). insb UniProt:Q321L1 (EMBL:CP000036 (167 aa) fasta scores: E()=2.9e-47, 99.200% id in 125 aa. This CDS contains a stop codon near the N-terminus
316401000977	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544
316401000978	Signal peptide predicted for ETEC0213 by SignalP 2.0 HMM (Signal peptide probability 0.992) with cleavage site probability 0.733 between residues 19 and 20
316401000980	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
316401000981	sensor kinase CusS; Provisional; Region: PRK09835
316401000982	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
316401000983	dimerization interface [polypeptide binding]; other site
316401000984	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316401000985	dimer interface [polypeptide binding]; other site
316401000986	phosphorylation site [posttranslational modification]
316401000987	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316401000988	ATP binding site [chemical binding]; other site
316401000989	Mg2+ binding site [ion binding]; other site
316401000990	G-X-G motif; other site
316401000991	2 probable transmembrane helices predicted for ETEC0217 by TMHMM2.0 at aa 12-34 and 188-207
316401000992	Signal peptide predicted for ETEC0217 by SignalP 2.0 HMM (Signal peptide probability 0.962) with cleavage site probability 0.822 between residues 38 and 39
316401000993	DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836
316401000994	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316401000995	active site
316401000996	phosphorylation site [posttranslational modification]
316401000997	intermolecular recognition site; other site
316401000998	dimerization interface [polypeptide binding]; other site
316401000999	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
316401001000	DNA binding site [nucleotide binding]
316401001001	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
316401001002	periplasmic copper-binding protein; Provisional; Region: PRK09838
316401001003	Signal peptide predicted for ETEC0220 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.915 between residues 23 and 24
316401001004	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
316401001005	HlyD family secretion protein; Region: HlyD_3; pfam13437
316401001006	Signal peptide predicted for ETEC0221 by SignalP 2.0 HMM (Signal peptide probability 0.973) with cleavage site probability 0.360 between residues 26 and 27
316401001007	1 probable transmembrane helix predicted for ETEC0221 by TMHMM2.0 at aa 7-29
316401001008	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
316401001009	12 probable transmembrane helices predicted for ETEC0222 by TMHMM2.0 at aa 13-32, 342-359, 364-386, 390-412, 446-468, 483-505, 532-554, 874-891, 898-920, 930-952, 985-1002 and 1017-1039
316401001010	Protein of unknown function, DUF; Region: DUF411; cl01142
316401001011	Signal peptide predicted for ETEC0223 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 19 and 20
316401001012	YHS domain; Region: YHS; pfam04945
316401001013	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
316401001014	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
316401001015	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
316401001016	motif II; other site
316401001017	8 probable transmembrane helices predicted for ETEC0224 by TMHMM2.0 at aa 158-177, 192-211, 223-245, 260-282, 415-437, 447-466, 758-780 and 784-806
316401001018	PS00017 ATP/GTP-binding site motif A (P-loop).
316401001019	PS00154 E1-E2 ATPases phosphorylation site.
316401001020	Protein of unknown function (DUF2933); Region: DUF2933; pfam11666
316401001021	Signal peptide predicted for ETEC0225 by SignalP 2.0 HMM (Signal peptide probability 0.937) with cleavage site probability 0.584 between residues 18 and 19
316401001022	2 probable transmembrane helices predicted for ETEC0225 by TMHMM2.0 at aa 4-20 and 27-46
316401001023	Peptidase family M23; Region: Peptidase_M23; pfam01551
316401001024	Signal peptide predicted for ETEC0227 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.987 between residues 20 and 21
316401001025	potential frameshift: common BLAST hit: gi|295697858|ref|YP_003602515.1| copper resistance protein A
316401001026	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
316401001027	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
316401001028	Signal peptide predicted for ETEC0228 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.629 between residues 32 and 33
316401001029	Multicopper oxidase; Region: Cu-oxidase; pfam00394
316401001030	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
316401001031	PS00079 Multicopper oxidases signature 1.
316401001032	PS00080 Multicopper oxidases signature 2.
316401001033	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
316401001034	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
316401001035	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
316401001036	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
316401001037	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
316401001038	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
316401001039	Transposase; Region: HTH_Tnp_1; pfam01527
316401001040	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
316401001041	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
316401001042	CopC domain; Region: CopC; pfam04234
316401001043	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
316401001044	8 probable transmembrane helices predicted for ETEC0234 by TMHMM2.0 at aa 4-26, 39-61, 88-110, 115-137, 152-174, 195-217, 232-254 and 277-299
316401001045	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
316401001046	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316401001047	active site
316401001048	phosphorylation site [posttranslational modification]
316401001049	intermolecular recognition site; other site
316401001050	dimerization interface [polypeptide binding]; other site
316401001051	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
316401001052	DNA binding site [nucleotide binding]
316401001053	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
316401001054	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
316401001055	dimerization interface [polypeptide binding]; other site
316401001056	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316401001057	dimer interface [polypeptide binding]; other site
316401001058	phosphorylation site [posttranslational modification]
316401001059	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316401001060	ATP binding site [chemical binding]; other site
316401001061	Mg2+ binding site [ion binding]; other site
316401001062	G-X-G motif; other site
316401001063	Signal peptide predicted for ETEC0236 by SignalP 2.0 HMM (Signal peptide probability 0.884) with cleavage site probability 0.356 between residues 32 and 33
316401001064	2 probable transmembrane helices predicted for ETEC0236 by TMHMM2.0 at aa 12-34 and 171-190
316401001065	Signal peptide predicted for ETEC0237 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 20 and 21
316401001066	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
316401001067	Transposase; Region: HTH_Tnp_1; pfam01527
316401001068	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
316401001069	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
316401001070	Similar to N-terminus of Escherichia coli o1:k1/apec. isec8 transposase. UniProt:Q19N68 (EMBL:DQ517526 (511 aa) fasta scores: E()=7.8e-123, 88.127% id in 379 aa, and to N-terminus of Escherichia coli. putative uncharacterized protein. UniProt:Q6KD23 (EMBL:AJ586888 (512 aa) fasta scores: E()=2e-124, 92.643% id in 367 aa
316401001071	Similar to C-terminus of Escherichia coli RhsE protein. UniProt:P24211 (682 aa) fasta scores: E()=5.9e-45, 71.875% id in 160 aa, and to C-terminus of Shigella sonnei (strain ss046). rhs core protein with extension. UniProt:Q3Z5C1 (EMBL:CP000038 (1402 aa) fasta scores: E()=3.1e-126, 97.853% id in 326 aa
316401001072	Signal peptide predicted for ETEC0242 by SignalP 2.0 HMM (Signal peptide probability 0.986) with cleavage site probability 0.875 between residues 18 and 19
316401001073	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
316401001074	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
316401001075	Transposase [DNA replication, recombination, and repair]; Region: COG5433
316401001076	Transposase [DNA replication, recombination, and repair]; Region: COG5433
316401001077	C-N hydrolase family amidase; Provisional; Region: PRK10438
316401001078	Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575
316401001079	putative active site [active]
316401001080	catalytic triad [active]
316401001081	dimer interface [polypeptide binding]; other site
316401001082	multimer interface [polypeptide binding]; other site
316401001083	C-lysozyme inhibitor; Provisional; Region: PRK09993
316401001084	Signal peptide predicted for ETEC0245 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 28 and 29
316401001085	PS00017 ATP/GTP-binding site motif A (P-loop).
316401001086	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
316401001087	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
316401001088	active site
316401001089	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
316401001090	2 probable transmembrane helices predicted for ETEC0246 by TMHMM2.0 at aa 10-32 and 39-61
316401001091	Signal peptide predicted for ETEC0246 by SignalP 2.0 HMM (Signal peptide probability 0.749) with cleavage site probability 0.457 between residues 32 and 33
316401001092	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
316401001093	dimer interface [polypeptide binding]; other site
316401001094	active site
316401001095	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
316401001096	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
316401001097	putative active site [active]
316401001098	putative dimer interface [polypeptide binding]; other site
316401001099	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
316401001100	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
316401001101	1 probable transmembrane helix predicted for ETEC0249 by TMHMM2.0 at aa 4-26
316401001102	Signal peptide predicted for ETEC0249 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.822 between residues 19 and 20
316401001103	RelB antitoxin; Region: RelB; cl01171
316401001104	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
316401001105	NlpC/P60 family; Region: NLPC_P60; pfam00877
316401001106	Signal peptide predicted for ETEC0251 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.676 between residues 25 and 26
316401001107	1 probable transmembrane helix predicted for ETEC0251 by TMHMM2.0 at aa 15-37
316401001108	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
316401001110	hypothetical protein; Validated; Region: PRK06778
316401001111	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
316401001112	ligand binding site [chemical binding]; other site
316401001113	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
316401001114	active site
316401001115	DNA polymerase IV; Validated; Region: PRK02406
316401001116	DNA binding site [nucleotide binding]
316401001117	putative antitoxin of the YafO-YafN toxin-antitoxin system; Provisional; Region: PRK09778
316401001118	putative toxin YafO; Provisional; Region: PRK09885
316401001119	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
316401001120	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
316401001121	Coenzyme A binding pocket [chemical binding]; other site
316401001122	Uncharacterized protein family UPF0027; Region: UPF0027; cl17455
316401001123	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
316401001124	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
316401001125	metal binding site [ion binding]; metal-binding site
316401001126	dimer interface [polypeptide binding]; other site
316401001127	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
316401001128	active site
316401001129	PS00103 Purine/pyrimidine phosphoribosyl transferases signature.
316401001130	fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077
316401001131	DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984
316401001132	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
316401001133	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
316401001134	trimer interface [polypeptide binding]; other site
316401001135	eyelet of channel; other site
316401001136	PS00576 General diffusion Gram-negative porins signature.
316401001137	Signal peptide predicted for ETEC0264 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 21 and 22
316401001138	gamma-glutamyl kinase; Provisional; Region: PRK05429
316401001139	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
316401001140	nucleotide binding site [chemical binding]; other site
316401001141	homotetrameric interface [polypeptide binding]; other site
316401001142	putative phosphate binding site [ion binding]; other site
316401001143	putative allosteric binding site; other site
316401001144	PUA domain; Region: PUA; pfam01472
316401001145	PS00902 Glutamate 5-kinase signature.
316401001146	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
316401001147	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
316401001148	putative catalytic cysteine [active]
316401001149	PS01223 Gamma-glutamyl phosphate reductase signature.
316401001150	integrase; Provisional; Region: int; PHA02601
316401001151	P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192
316401001152	Int/Topo IB signature motif; other site
316401001153	Helix-turn-helix domain; Region: HTH_17; pfam12728
316401001154	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
316401001155	Active Sites [active]
316401001156	Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896
316401001157	Predicted transcriptional regulator [Transcription]; Region: COG2932
316401001158	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
316401001159	non-specific DNA binding site [nucleotide binding]; other site
316401001160	salt bridge; other site
316401001161	sequence-specific DNA binding site [nucleotide binding]; other site
316401001162	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
316401001163	Catalytic site [active]
316401001164	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
316401001165	non-specific DNA binding site [nucleotide binding]; other site
316401001166	salt bridge; other site
316401001167	sequence-specific DNA binding site [nucleotide binding]; other site
316401001168	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
316401001169	DNA-binding site [nucleotide binding]; DNA binding site
316401001170	PerC transcriptional activator; Region: PerC; pfam06069
316401001171	DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869
316401001172	PS00092 N-6 Adenine-specific DNA methylases signature.
316401001173	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
316401001174	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
316401001175	KilA-N domain; Region: KilA-N; pfam04383
316401001176	Protein of unknown function (DUF968); Region: DUF968; pfam06147
316401001177	Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530
316401001178	PS00228 Tubulin-beta mRNA autoregulation signal.
316401001179	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
316401001180	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
316401001181	PS00017 ATP/GTP-binding site motif A (P-loop).
316401001182	Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938
316401001183	3 probable transmembrane helices predicted for ETEC0282 by TMHMM2.0 at aa 20-42, 49-71 and 75-94
316401001184	The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes.  But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736
316401001185	N-acetyl-D-glucosamine binding site [chemical binding]; other site
316401001186	catalytic residue [active]
316401001187	1 probable transmembrane helix predicted for ETEC0284 by TMHMM2.0 at aa 7-29
316401001188	Signal peptide predicted for ETEC0285 by SignalP 2.0 HMM (Signal peptide probability 0.987) with cleavage site probability 0.934 between residues 47 and 48
316401001189	1 probable transmembrane helix predicted for ETEC0285 by TMHMM2.0 at aa 20-42
316401001190	1 probable transmembrane helix predicted for ETEC0286 by TMHMM2.0 at aa 20-42
316401001191	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
316401001192	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
316401001193	active site
316401001194	Phage terminase, small subunit; Region: Terminase_4; pfam05119
316401001195	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
316401001196	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401001197	Phage-related protein [Function unknown]; Region: COG4695
316401001198	Phage portal protein; Region: Phage_portal; pfam04860
316401001199	Phage head maturation protease [General function prediction only]; Region: COG3740
316401001200	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
316401001201	Phage capsid family; Region: Phage_capsid; pfam05065
316401001202	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
316401001203	oligomerization interface [polypeptide binding]; other site
316401001204	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
316401001205	Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386
316401001206	Phage tail sheath protein; Region: Phage_sheath_1; pfam04984
316401001207	Phage tail tube protein; Region: Tail_tube; pfam10618
316401001208	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
316401001209	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
316401001210	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
316401001211	PS00017 ATP/GTP-binding site motif A (P-loop).
316401001212	2 probable transmembrane helices predicted for ETEC0300 by TMHMM2.0 at aa 393-415 and 427-449
316401001213	Signal peptide predicted for ETEC0301 by SignalP 2.0 HMM (Signal peptide probability 0.810) with cleavage site probability 0.500 between residues 23 and 24
316401001214	1 probable transmembrane helix predicted for ETEC0301 by TMHMM2.0 at aa 4-26
316401001215	Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228
316401001216	DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157
316401001217	Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379
316401001218	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
316401001219	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
316401001220	Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; pfam06890
316401001221	Phage protein GP46; Region: GP46; pfam07409
316401001222	Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299
316401001223	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3778
316401001224	Phage Tail Collar Domain; Region: Collar; pfam07484
316401001225	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
316401001226	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
316401001227	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
316401001228	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
316401001229	catalytic residues [active]
316401001230	catalytic nucleophile [active]
316401001231	Presynaptic Site I dimer interface [polypeptide binding]; other site
316401001232	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
316401001233	Synaptic Flat tetramer interface [polypeptide binding]; other site
316401001234	Synaptic Site I dimer interface [polypeptide binding]; other site
316401001235	DNA binding site [nucleotide binding]
316401001236	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
316401001237	DNA-binding interface [nucleotide binding]; DNA binding site
316401001238	PS00397 Site-specific recombinases active site.
316401001239	PS00398 Site-specific recombinases signature 2.
316401001240	GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440
316401001241	GIY-YIG motif/motif A; other site
316401001242	putative active site [active]
316401001243	putative metal binding site [ion binding]; other site
316401001244	transcriptional regulator YdeO; Provisional; Region: PRK09940
316401001245	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316401001246	PS00041 Bacterial regulatory proteins, araC family signature.
316401001247	Similar, but truncated at the N-terminus, to Shigella flexneri. TnpF UniProt:Q9XCH9 (EMBL:AF141323 (263 aa) fasta scores: E()=4e-15, 71.212% id in 66 aa, and to N-terminus of Shigella sonnei (strain ss046). IS2 orf2. UniProt:Q3YZL3 (EMBL:CP000038 (117 aa) fasta scores: E()=4.6e-26, 98.571% id in 70 aa
316401001248	integrase; Provisional; Region: PRK09692
316401001249	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
316401001250	active site
316401001251	Int/Topo IB signature motif; other site
316401001252	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
316401001253	AntA/AntB antirepressor; Region: AntA; pfam08346
316401001254	PS00017 ATP/GTP-binding site motif A (P-loop).
316401001255	Domain of unknown function (DUF4222); Region: DUF4222; pfam13973
316401001256	Ash protein family; Region: Phage_ASH; pfam10554
316401001257	1 probable transmembrane helix predicted for ETEC0321 by TMHMM2.0 at aa 260-282
316401001258	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
316401001259	Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778
316401001260	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
316401001261	active site
316401001262	metal binding site [ion binding]; metal-binding site
316401001263	interdomain interaction site; other site
316401001264	PS00017 ATP/GTP-binding site motif A (P-loop).
316401001265	1 probable transmembrane helix predicted for ETEC0329 by TMHMM2.0 at aa 15-37
316401001266	1 probable transmembrane helix predicted for ETEC0334 by TMHMM2.0 at aa 46-65
316401001267	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
316401001268	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
316401001269	Transcriptional regulator [Transcription]; Region: LysR; COG0583
316401001270	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
316401001271	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
316401001272	XdhC Rossmann domain; Region: XdhC_C; pfam13478
316401001273	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
316401001274	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315
316401001275	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
316401001276	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
316401001277	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
316401001278	aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433
316401001279	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2; pfam00111
316401001280	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
316401001281	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
316401001282	PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature.
316401001284	Transposase; Region: HTH_Tnp_1; pfam01527
316401001285	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
316401001286	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
316401001287	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
316401001288	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
316401001289	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
316401001290	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
316401001291	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
316401001292	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
316401001293	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
316401001294	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
316401001295	Signal peptide predicted for ETEC0347 by SignalP 2.0 HMM (Signal peptide probability 0.771) with cleavage site probability 0.760 between residues 24 and 25
316401001296	1 probable transmembrane helix predicted for ETEC0348 by TMHMM2.0 at aa 13-35
316401001297	Signal peptide predicted for ETEC0348 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.740 between residues 27 and 28
316401001298	Signal peptide predicted for ETEC0349 by SignalP 2.0 HMM (Signal peptide probability 0.983) with cleavage site probability 0.807 between residues 23 and 24
316401001299	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
316401001300	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
316401001301	PS00445 FGGY family of carbohydrate kinases signature 2.
316401001302	Signal peptide predicted for ETEC0350 by SignalP 2.0 HMM (Signal peptide probability 0.791) with cleavage site probability 0.767 between residues 29 and 30
316401001303	putative fimbrial protein TcfA; Provisional; Region: PRK15308
316401001304	Signal peptide predicted for ETEC0351 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 20 and 21
316401001305	Signal peptide predicted for ETEC0352 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 22 and 23
316401001306	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
316401001307	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
316401001308	DNA binding residues [nucleotide binding]
316401001309	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
316401001310	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
316401001311	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
316401001312	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
316401001313	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
316401001314	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
316401001315	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
316401001316	1 probable transmembrane helix predicted for ETEC0357 by TMHMM2.0 at aa 21-43
316401001317	PS00017 ATP/GTP-binding site motif A (P-loop).
316401001318	right oriC-binding transcriptional activator; Provisional; Region: PRK15121
316401001319	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316401001320	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
316401001321	Predicted membrane protein [Function unknown]; Region: COG3059
316401001322	3 probable transmembrane helices predicted for ETEC0359 by TMHMM2.0 at aa 16-38, 86-105 and 112-134
316401001323	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
316401001324	Signal peptide predicted for ETEC0360 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 22 and 23
316401001325	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010
316401001326	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
316401001327	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
316401001328	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
316401001329	PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site.
316401001330	PS00017 ATP/GTP-binding site motif A (P-loop).
316401001331	Cupin; Region: Cupin_6; pfam12852
316401001332	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
316401001333	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316401001334	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
316401001335	Cysteine-rich domain; Region: CCG; pfam02754
316401001336	Cysteine-rich domain; Region: CCG; pfam02754
316401001337	iron-sulfur cluster-binding protein; Region: TIGR00273
316401001338	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
316401001339	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
316401001340	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
316401001341	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401001342	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401001343	Uncharacterized conserved protein [Function unknown]; Region: COG1556
316401001344	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
316401001345	2 probable transmembrane helices predicted for ETEC0366 by TMHMM2.0 at aa 24-43 and 186-208
316401001346	choline dehydrogenase; Validated; Region: PRK02106
316401001347	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
316401001348	PS00624 GMC oxidoreductases signature 2.
316401001349	PS00623 GMC oxidoreductases signature 1.
316401001350	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
316401001351	NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090
316401001352	tetrameric interface [polypeptide binding]; other site
316401001353	NAD binding site [chemical binding]; other site
316401001354	catalytic residues [active]
316401001355	PS00070 Aldehyde dehydrogenases cysteine active site.
316401001356	PS00687 Aldehyde dehydrogenases glutamic acid active site.
316401001357	transcriptional regulator BetI; Validated; Region: PRK00767
316401001358	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
316401001359	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
316401001360	PS01081 Bacterial regulatory proteins, tetR family signature.
316401001361	choline transport protein BetT; Provisional; Region: PRK09928
316401001362	12 probable transmembrane helices predicted for ETEC0370 by TMHMM2.0 at aa 13-35, 55-77, 90-112, 142-164, 193-215, 230-252, 264-286, 318-337, 349-368, 399-421, 451-473 and 477-496
316401001363	PS01303 BCCT family of transporters signature.
316401001364	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
316401001365	DNA binding residues [nucleotide binding]
316401001366	dimerization interface [polypeptide binding]; other site
316401001367	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
316401001368	DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094
316401001369	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401001370	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
316401001371	dimerization interface [polypeptide binding]; other site
316401001372	PS00044 Bacterial regulatory proteins, lysR family signature.
316401001373	Signal peptide predicted for ETEC0372 by SignalP 2.0 HMM (Signal peptide probability 0.746) with cleavage site probability 0.738 between residues 25 and 26
316401001374	Protein of unknown function (DUF1097); Region: DUF1097; pfam06496
316401001375	4 probable transmembrane helices predicted for ETEC0373 by TMHMM2.0 at aa 29-51, 58-80, 85-104 and 109-131
316401001376	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
316401001377	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
316401001378	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
316401001379	Protein of unknown function (DUF2877); Region: DUF2877; pfam11392
316401001380	Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074
316401001381	CoA binding domain; Region: CoA_binding; pfam02629
316401001382	CoA-ligase; Region: Ligase_CoA; pfam00549
316401001383	potential frameshift: common BLAST hit: gi|16128306|ref|NP_414855.1| conserved protein
316401001384	membrane protein FdrA; Validated; Region: PRK06091
316401001385	Protein of unknown function (DUF1116); Region: DUF1116; pfam06545
316401001386	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401001387	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
316401001388	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
316401001389	putative substrate binding site [chemical binding]; other site
316401001390	nucleotide binding site [chemical binding]; other site
316401001391	nucleotide binding site [chemical binding]; other site
316401001392	homodimer interface [polypeptide binding]; other site
316401001393	putative deaminase; Validated; Region: PRK06846
316401001394	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
316401001395	active site
316401001396	Signal peptide predicted for ETEC0381 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.860 between residues 33 and 34
316401001397	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
316401001398	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
316401001399	putative NAD(P) binding site [chemical binding]; other site
316401001400	putative substrate binding site [chemical binding]; other site
316401001401	catalytic Zn binding site [ion binding]; other site
316401001402	structural Zn binding site [ion binding]; other site
316401001403	dimer interface [polypeptide binding]; other site
316401001404	PS00190 Cytochrome c family heme-binding site signature.
316401001405	PS00059 Zinc-containing alcohol dehydrogenases signature.
316401001406	PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature.
316401001407	The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949
316401001408	6 probable transmembrane helices predicted for ETEC0385 by TMHMM2.0 at aa 20-42, 54-76, 86-103, 136-153, 163-180 and 200-217
316401001409	hypothetical protein; Provisional; Region: PRK09929
316401001410	Signal peptide predicted for ETEC0386 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 21 and 22
316401001411	propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424
316401001412	Propionate catabolism activator; Region: PrpR_N; pfam06506
316401001413	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316401001414	Walker A motif; other site
316401001415	ATP binding site [chemical binding]; other site
316401001416	Walker B motif; other site
316401001417	arginine finger; other site
316401001418	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
316401001419	PS00688 Sigma-54 interaction domain C-terminal part signature.
316401001420	PS00134 Serine proteases, trypsin family, histidine active site.
316401001421	PS00676 Sigma-54 interaction domain ATP-binding region B signature.
316401001422	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
316401001423	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
316401001424	tetramer interface [polypeptide binding]; other site
316401001425	active site
316401001426	Mg2+/Mn2+ binding site [ion binding]; other site
316401001427	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
316401001428	Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117
316401001429	dimer interface [polypeptide binding]; other site
316401001430	active site
316401001431	citrylCoA binding site [chemical binding]; other site
316401001432	oxalacetate/citrate binding site [chemical binding]; other site
316401001433	coenzyme A binding site [chemical binding]; other site
316401001434	catalytic triad [active]
316401001435	PS00017 ATP/GTP-binding site motif A (P-loop).
316401001436	PS00480 Citrate synthase signature.
316401001437	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
316401001438	2-methylcitrate dehydratase; Region: prpD; TIGR02330
316401001439	PS00225 Crystallins beta and gamma 'Greek key' motif signature.
316401001440	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
316401001441	Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967
316401001442	acyl-activating enzyme (AAE) consensus motif; other site
316401001443	putative AMP binding site [chemical binding]; other site
316401001444	putative active site [active]
316401001445	putative CoA binding site [chemical binding]; other site
316401001446	PS00455 Putative AMP-binding domain signature.
316401001447	nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484
316401001448	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
316401001449	Na binding site [ion binding]; other site
316401001450	putative substrate binding site [chemical binding]; other site
316401001451	12 probable transmembrane helices predicted for ETEC0392 by TMHMM2.0 at aa 21-43, 53-75, 96-118, 128-150, 152-174, 194-216, 223-245, 255-277, 289-311, 321-340, 360-379 and 383-402
316401001452	cytosine deaminase; Provisional; Region: PRK09230
316401001453	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
316401001454	active site
316401001455	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
316401001456	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401001457	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425
316401001458	dimerization interface [polypeptide binding]; other site
316401001459	PS00044 Bacterial regulatory proteins, lysR family signature.
316401001460	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
316401001461	active site clefts [active]
316401001462	zinc binding site [ion binding]; other site
316401001463	dimer interface [polypeptide binding]; other site
316401001464	PS00704 Prokaryotic-type carbonic anhydrases signature 1.
316401001465	PS00705 Prokaryotic-type carbonic anhydrases signature 2.
316401001466	Cyanate lyase [Inorganic ion transport and metabolism]; Region: CynS; COG1513
316401001467	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
316401001468	oligomer interface [polypeptide binding]; other site
316401001469	active site
316401001470	putative cyanate transporter; Provisional; Region: cynX; PRK09705
316401001471	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401001472	12 probable transmembrane helices predicted for ETEC0397 by TMHMM2.0 at aa 2-24, 34-56, 68-85, 90-112, 124-146, 156-173, 201-223, 228-250, 263-282, 287-309, 321-340 and 355-374
316401001473	galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527
316401001474	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
316401001475	active site
316401001476	substrate binding site [chemical binding]; other site
316401001477	trimer interface [polypeptide binding]; other site
316401001478	CoA binding site [chemical binding]; other site
316401001479	PS00101 Hexapeptide-repeat containing-transferases signature.
316401001480	LacY proton/sugar symporter; Region: LacY_symp; pfam01306
316401001481	11 probable transmembrane helices predicted for ETEC0399 by TMHMM2.0 at aa 13-35, 45-67, 76-98, 103-125, 145-164, 168-187, 222-239, 261-283, 304-326, 346-368 and 380-402
316401001482	PS00897 LacY family proton/sugar symporters signature 2.
316401001483	PS00896 LacY family proton/sugar symporters signature 1.
316401001484	beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525
316401001485	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
316401001486	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
316401001487	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
316401001488	Beta galactosidase small chain; Region: Bgal_small_N; pfam02929
316401001489	PS00017 ATP/GTP-binding site motif A (P-loop).
316401001490	PS00608 Glycosyl hydrolases family 2 acid/base catalyst.
316401001491	PS00719 Glycosyl hydrolases family 2 signature 1.
316401001492	lac repressor; Reviewed; Region: lacI; PRK09526
316401001493	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
316401001494	DNA binding site [nucleotide binding]
316401001495	domain linker motif; other site
316401001496	Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574
316401001497	ligand binding site [chemical binding]; other site
316401001498	dimerization interface (open form) [polypeptide binding]; other site
316401001499	dimerization interface (closed form) [polypeptide binding]; other site
316401001500	PS00356 Bacterial regulatory proteins, lacI family signature.
316401001501	PS00225 Crystallins beta and gamma 'Greek key' motif signature.
316401001502	DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834
316401001503	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
316401001504	Bacterial transcriptional regulator; Region: IclR; pfam01614
316401001505	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
316401001506	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
316401001507	Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365
316401001508	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
316401001509	putative active site [active]
316401001510	Fe(II) binding site [ion binding]; other site
316401001511	putative dimer interface [polypeptide binding]; other site
316401001512	putative tetramer interface [polypeptide binding]; other site
316401001513	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
316401001514	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
316401001515	nucleophilic elbow; other site
316401001516	catalytic triad; other site
316401001517	2-keto-4-pentenoate hydratase; Provisional; Region: mhpD; PRK11342
316401001518	acetaldehyde dehydrogenase; Validated; Region: PRK08300
316401001519	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
316401001520	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
316401001521	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
316401001522	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
316401001523	active site
316401001524	catalytic residues [active]
316401001525	metal binding site [ion binding]; metal-binding site
316401001526	DmpG-like communication domain; Region: DmpG_comm; pfam07836
316401001527	putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551
316401001528	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401001529	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401001530	Signal peptide predicted for ETEC0409 by SignalP 2.0 HMM (Signal peptide probability 0.884) with cleavage site probability 0.778 between residues 33 and 34
316401001531	12 probable transmembrane helices predicted for ETEC0409 by TMHMM2.0 at aa 13-35, 50-69, 82-101, 106-128, 141-163, 167-189, 219-241, 251-273, 280-299, 309-331, 338-360 and 370-392
316401001532	PS00216 Sugar transport proteins signature 1.
316401001533	PS00217 Sugar transport proteins signature 2.
316401001534	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122
316401001535	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
316401001536	S-formylglutathione hydrolase; Region: PLN02442
316401001537	PS00300 SRP54-type proteins GTP-binding domain signature.
316401001538	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
316401001539	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
316401001540	substrate binding site [chemical binding]; other site
316401001541	catalytic Zn binding site [ion binding]; other site
316401001542	NAD binding site [chemical binding]; other site
316401001543	structural Zn binding site [ion binding]; other site
316401001544	dimer interface [polypeptide binding]; other site
316401001545	PS00059 Zinc-containing alcohol dehydrogenases signature.
316401001546	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
316401001547	putative metal binding site [ion binding]; other site
316401001548	putative homodimer interface [polypeptide binding]; other site
316401001549	putative homotetramer interface [polypeptide binding]; other site
316401001550	putative homodimer-homodimer interface [polypeptide binding]; other site
316401001551	putative allosteric switch controlling residues; other site
316401001552	1 probable transmembrane helix predicted for ETEC0414 by TMHMM2.0 at aa 5-27
316401001553	Signal peptide predicted for ETEC0414 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 19 and 20
316401001554	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
316401001555	putative trimer interface [polypeptide binding]; other site
316401001556	putative CoA binding site [chemical binding]; other site
316401001557	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
316401001558	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
316401001559	DXD motif; other site
316401001560	4 probable transmembrane helices predicted for ETEC0416 by TMHMM2.0 at aa 4-21, 269-291, 306-328 and 340-362
316401001561	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
316401001562	1 probable transmembrane helix predicted for ETEC0418 by TMHMM2.0 at aa 21-43
316401001563	ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521
316401001564	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
316401001565	substrate binding pocket [chemical binding]; other site
316401001566	membrane-bound complex binding site; other site
316401001567	hinge residues; other site
316401001568	Signal peptide predicted for ETEC0419 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 22 and 23
316401001569	taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248
316401001570	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
316401001571	Walker A/P-loop; other site
316401001572	ATP binding site [chemical binding]; other site
316401001573	Q-loop/lid; other site
316401001574	ABC transporter signature motif; other site
316401001575	Walker B; other site
316401001576	D-loop; other site
316401001577	H-loop/switch region; other site
316401001578	PS00017 ATP/GTP-binding site motif A (P-loop).
316401001579	PS00211 ABC transporters family signature.
316401001580	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
316401001581	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401001582	dimer interface [polypeptide binding]; other site
316401001583	conserved gate region; other site
316401001584	putative PBP binding loops; other site
316401001585	ABC-ATPase subunit interface; other site
316401001586	Signal peptide predicted for ETEC0421 by SignalP 2.0 HMM (Signal peptide probability 0.821) with cleavage site probability 0.391 between residues 42 and 43
316401001587	6 probable transmembrane helices predicted for ETEC0421 by TMHMM2.0 at aa 20-42, 85-107, 119-141, 146-165, 186-208 and 236-258
316401001588	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
316401001589	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
316401001590	taurine dioxygenase; Reviewed; Region: tauD; PRK09553
316401001591	PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide.
316401001592	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
316401001593	dimer interface [polypeptide binding]; other site
316401001594	active site
316401001595	Schiff base residues; other site
316401001596	PS00169 Delta-aminolevulinic acid dehydratase active site.
316401001597	IS2 transposase TnpB; Reviewed; Region: PRK09409
316401001598	HTH-like domain; Region: HTH_21; pfam13276
316401001599	Integrase core domain; Region: rve; pfam00665
316401001600	Integrase core domain; Region: rve_3; pfam13683
316401001601	IS2 repressor TnpA; Reviewed; Region: PRK09413
316401001602	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
316401001603	Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253
316401001604	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
316401001605	Autotransporter beta-domain; Region: Autotransporter; pfam03797
316401001606	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832
316401001607	beta-lactam binding protein AmpH; Provisional; Region: PRK10662
316401001608	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
316401001609	Signal peptide predicted for ETEC0429 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 21 and 22
316401001610	microcin B17 transporter; Reviewed; Region: PRK11098
316401001611	Signal peptide predicted for ETEC0430 by SignalP 2.0 HMM (Signal peptide probability 0.891) with cleavage site probability 0.452 between residues 31 and 32
316401001612	8 probable transmembrane helices predicted for ETEC0430 by TMHMM2.0 at aa 12-31, 57-79, 86-108, 138-160, 204-226, 241-263, 309-327 and 337-359
316401001613	Protein of unknown function (DUF1615); Region: DUF1615; pfam07759
316401001614	Signal peptide predicted for ETEC0431 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.787 between residues 24 and 25
316401001615	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401001616	PS00017 ATP/GTP-binding site motif A (P-loop).
316401001617	Protein of unknown function (DUF2755); Region: DUF2755; pfam10954
316401001618	2 probable transmembrane helices predicted for ETEC0432 by TMHMM2.0 at aa 25-47 and 68-90
316401001619	Protein of unknown function (DUF2754); Region: DUF2754; pfam10953
316401001620	2 probable transmembrane helices predicted for ETEC0433 by TMHMM2.0 at aa 13-32 and 37-59
316401001621	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
316401001622	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
316401001623	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
316401001624	PS00844 D-alanine--D-alanine ligase signature 2.
316401001625	PS00843 D-alanine--D-alanine ligase signature 1.
316401001626	PS00017 ATP/GTP-binding site motif A (P-loop).
316401001627	anti-RssB factor; Provisional; Region: PRK10244
316401001628	alkaline phosphatase; Provisional; Region: PRK10518
316401001629	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
316401001630	dimer interface [polypeptide binding]; other site
316401001631	active site
316401001632	Signal peptide predicted for ETEC0436 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.896 between residues 21 and 22
316401001633	PS00123 Alkaline phosphatase active site.
316401001634	PS00017 ATP/GTP-binding site motif A (P-loop).
316401001635	hypothetical protein; Provisional; Region: PRK11505
316401001636	psiF repeat; Region: PsiF_repeat; pfam07769
316401001637	psiF repeat; Region: PsiF_repeat; pfam07769
316401001638	Signal peptide predicted for ETEC0437 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.961 between residues 21 and 22
316401001639	1 probable transmembrane helix predicted for ETEC0437 by TMHMM2.0 at aa 5-22
316401001640	diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245
316401001641	MASE2 domain; Region: MASE2; pfam05230
316401001642	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316401001643	metal binding site [ion binding]; metal-binding site
316401001644	active site
316401001645	I-site; other site
316401001646	5 probable transmembrane helices predicted for ETEC0438 by TMHMM2.0 at aa 41-63, 68-87, 108-130, 145-167 and 174-196
316401001647	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
316401001648	pyrroline-5-carboxylate reductase; Region: PLN02688
316401001649	PS00521 Delta 1-pyrroline-5-carboxylate reductase signature.
316401001650	hypothetical protein; Validated; Region: PRK00124
316401001651	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
316401001652	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
316401001653	ADP binding site [chemical binding]; other site
316401001654	magnesium binding site [ion binding]; other site
316401001655	putative shikimate binding site; other site
316401001656	PS00017 ATP/GTP-binding site motif A (P-loop).
316401001657	PS01128 Shikimate kinase signature.
316401001658	hypothetical protein; Provisional; Region: PRK10380
316401001659	hypothetical protein; Provisional; Region: PRK10481
316401001660	hypothetical protein; Provisional; Region: PRK10579
316401001661	Protein of unknown function (DUF2773); Region: DUF2773; pfam10971
316401001662	DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974
316401001663	fructokinase; Reviewed; Region: PRK09557
316401001664	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
316401001665	nucleotide binding site [chemical binding]; other site
316401001666	PS01125 ROK family signature.
316401001667	MFS transport protein AraJ; Provisional; Region: PRK10091
316401001668	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401001669	putative substrate translocation pore; other site
316401001670	12 probable transmembrane helices predicted for ETEC0448 by TMHMM2.0 at aa 5-27, 42-63, 70-89, 94-116, 129-151, 156-178, 199-221, 236-255, 262-284, 294-316, 323-342 and 352-374
316401001671	Signal peptide predicted for ETEC0448 by SignalP 2.0 HMM (Signal peptide probability 0.940) with cleavage site probability 0.558 between residues 18 and 19
316401001672	exonuclease subunit SbcC; Provisional; Region: PRK10246
316401001673	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316401001674	Walker A/P-loop; other site
316401001675	ATP binding site [chemical binding]; other site
316401001676	Q-loop/lid; other site
316401001677	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316401001678	ABC transporter signature motif; other site
316401001679	Walker B; other site
316401001680	D-loop; other site
316401001681	H-loop/switch region; other site
316401001682	PS00017 ATP/GTP-binding site motif A (P-loop).
316401001683	PS00017 ATP/GTP-binding site motif A (P-loop).
316401001684	exonuclease subunit SbcD; Provisional; Region: PRK10966
316401001685	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
316401001686	active site
316401001687	metal binding site [ion binding]; metal-binding site
316401001688	DNA binding site [nucleotide binding]
316401001689	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
316401001690	transcriptional regulator PhoB; Provisional; Region: PRK10161
316401001691	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316401001692	active site
316401001693	phosphorylation site [posttranslational modification]
316401001694	intermolecular recognition site; other site
316401001695	dimerization interface [polypeptide binding]; other site
316401001696	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
316401001697	DNA binding site [nucleotide binding]
316401001698	phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006
316401001699	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
316401001700	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316401001701	putative active site [active]
316401001702	heme pocket [chemical binding]; other site
316401001703	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316401001704	dimer interface [polypeptide binding]; other site
316401001705	phosphorylation site [posttranslational modification]
316401001706	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316401001707	ATP binding site [chemical binding]; other site
316401001708	Mg2+ binding site [ion binding]; other site
316401001709	G-X-G motif; other site
316401001710	Signal peptide predicted for ETEC0452 by SignalP 2.0 HMM (Signal peptide probability 0.787) with cleavage site probability 0.729 between residues 37 and 38
316401001711	1 probable transmembrane helix predicted for ETEC0452 by TMHMM2.0 at aa 12-34
316401001712	branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433
316401001713	Signal peptide predicted for ETEC0454 by SignalP 2.0 HMM (Signal peptide probability 0.769) with cleavage site probability 0.694 between residues 24 and 25
316401001714	12 probable transmembrane helices predicted for ETEC0454 by TMHMM2.0 at aa 13-35, 45-67, 80-99, 119-141, 148-170, 190-212, 225-247, 276-298, 305-327, 337-359, 371-393 and 408-426
316401001715	putative proline-specific permease; Provisional; Region: proY; PRK10580
316401001716	Spore germination protein; Region: Spore_permease; cl17796
316401001717	Signal peptide predicted for ETEC0455 by SignalP 2.0 HMM (Signal peptide probability 0.977) with cleavage site probability 0.481 between residues 36 and 37
316401001718	12 probable transmembrane helices predicted for ETEC0455 by TMHMM2.0 at aa 16-34, 44-63, 83-105, 120-142, 154-176, 196-218, 239-261, 276-298, 329-351, 356-378, 399-421 and 426-445
316401001719	PS00218 Amino acid permeases signature.
316401001720	maltodextrin glucosidase; Provisional; Region: PRK10785
316401001721	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
316401001722	homodimer interface [polypeptide binding]; other site
316401001723	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
316401001724	active site
316401001725	homodimer interface [polypeptide binding]; other site
316401001726	catalytic site [active]
316401001727	acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045
316401001728	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
316401001729	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
316401001730	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
316401001731	tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449
316401001732	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
316401001733	1 probable transmembrane helix predicted for ETEC0460 by TMHMM2.0 at aa 20-39
316401001734	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
316401001735	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
316401001736	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
316401001737	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
316401001738	Signal peptide predicted for ETEC0461 by SignalP 2.0 HMM (Signal peptide probability 0.688) with cleavage site probability 0.576 between residues 30 and 31
316401001739	6 probable transmembrane helices predicted for ETEC0461 by TMHMM2.0 at aa 7-29, 450-472, 475-497, 502-524, 548-570 and 580-602
316401001740	PS00761 Signal peptidases I signature 3.
316401001741	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
316401001742	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
316401001743	Protein export membrane protein; Region: SecD_SecF; pfam02355
316401001744	6 probable transmembrane helices predicted for ETEC0462 by TMHMM2.0 at aa 24-46, 143-162, 169-191, 195-217, 248-270 and 275-297
316401001745	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
316401001746	active site
316401001747	PS00190 Cytochrome c family heme-binding site signature.
316401001748	nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106
316401001749	Signal peptide predicted for ETEC0464 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 22 and 23
316401001750	hypothetical protein; Provisional; Region: PRK11530
316401001751	Signal peptide predicted for ETEC0465 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.550 between residues 21 and 22
316401001752	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401001753	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
316401001754	ATP cone domain; Region: ATP-cone; pfam03477
316401001755	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
316401001756	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
316401001757	catalytic motif [active]
316401001758	Zn binding site [ion binding]; other site
316401001759	riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227
316401001760	PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature.
316401001761	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
316401001762	homopentamer interface [polypeptide binding]; other site
316401001763	active site
316401001764	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
316401001765	putative RNA binding site [nucleotide binding]; other site
316401001766	thiamine monophosphate kinase; Provisional; Region: PRK05731
316401001767	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
316401001768	ATP binding site [chemical binding]; other site
316401001769	dimerization interface [polypeptide binding]; other site
316401001770	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
316401001771	tetramer interfaces [polypeptide binding]; other site
316401001772	binuclear metal-binding site [ion binding]; other site
316401001773	Signal peptide predicted for ETEC0471 by SignalP 2.0 HMM (Signal peptide probability 0.880) with cleavage site probability 0.748 between residues 44 and 45
316401001774	3 probable transmembrane helices predicted for ETEC0471 by TMHMM2.0 at aa 21-43, 53-75 and 141-163
316401001775	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
316401001776	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
316401001777	active site
316401001778	catalytic tetrad [active]
316401001779	1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204
316401001780	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
316401001781	TPP-binding site; other site
316401001782	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
316401001783	PYR/PP interface [polypeptide binding]; other site
316401001784	dimer interface [polypeptide binding]; other site
316401001785	TPP binding site [chemical binding]; other site
316401001786	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
316401001787	PS00802 Transketolase signature 2.
316401001788	PS00801 Transketolase signature 1.
316401001789	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
316401001790	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
316401001791	substrate binding pocket [chemical binding]; other site
316401001792	chain length determination region; other site
316401001793	substrate-Mg2+ binding site; other site
316401001794	catalytic residues [active]
316401001795	aspartate-rich region 1; other site
316401001796	active site lid residues [active]
316401001797	aspartate-rich region 2; other site
316401001798	PS00017 ATP/GTP-binding site motif A (P-loop).
316401001799	PS00444 Polyprenyl synthetases signature 2.
316401001800	PS00723 Polyprenyl synthetases signature 1.
316401001801	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
316401001802	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
316401001803	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
316401001804	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
316401001805	Ligand Binding Site [chemical binding]; other site
316401001806	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
316401001807	active site residue [active]
316401001808	oxidative-stress-resistance chaperone; Provisional; Region: PRK11574
316401001809	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
316401001810	conserved cys residue [active]
316401001811	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
316401001812	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
316401001813	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
316401001814	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
316401001815	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
316401001816	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401001817	Major Facilitator Superfamily; Region: MFS_1; pfam07690
316401001818	putative substrate translocation pore; other site
316401001819	12 probable transmembrane helices predicted for ETEC0480 by TMHMM2.0 at aa 13-35, 50-72, 79-98, 102-124, 137-159, 164-186, 217-239, 254-273, 280-302, 306-328, 341-363 and 368-385
316401001820	protoheme IX farnesyltransferase; Provisional; Region: PRK13362
316401001821	UbiA prenyltransferase family; Region: UbiA; pfam01040
316401001822	9 probable transmembrane helices predicted for ETEC0481 by TMHMM2.0 at aa 12-34, 38-60, 81-103, 108-127, 134-156, 161-183, 209-231, 235-252 and 264-286
316401001823	PS00943 UbiA prenyltransferase family signature.
316401001824	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
316401001825	Subunit I/III interface [polypeptide binding]; other site
316401001826	Subunit III/IV interface [polypeptide binding]; other site
316401001827	5 probable transmembrane helices predicted for ETEC0483 by TMHMM2.0 at aa 27-49, 69-91, 98-118, 138-160 and 181-203
316401001828	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
316401001829	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
316401001830	D-pathway; other site
316401001831	Putative ubiquinol binding site [chemical binding]; other site
316401001832	Low-spin heme (heme b) binding site [chemical binding]; other site
316401001833	Putative water exit pathway; other site
316401001834	Binuclear center (heme o3/CuB) [ion binding]; other site
316401001835	K-pathway; other site
316401001836	Putative proton exit pathway; other site
316401001837	14 probable transmembrane helices predicted for ETEC0484 by TMHMM2.0 at aa 15-37, 57-79, 105-127, 140-162, 191-213, 233-255, 275-297, 310-332, 347-369, 382-404, 414-436, 457-479, 494-516 and 590-612
316401001838	PS00077 Heme-copper oxidase catalytic subunit, copper B binding region signature.
316401001839	cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525
316401001840	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
316401001841	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
316401001842	3 probable transmembrane helices predicted for ETEC0485 by TMHMM2.0 at aa 12-30, 45-67 and 88-110
316401001843	Signal peptide predicted for ETEC0485 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.594 between residues 30 and 31
316401001844	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401001845	muropeptide transporter; Reviewed; Region: ampG; PRK11902
316401001846	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401001847	putative substrate translocation pore; other site
316401001848	14 probable transmembrane helices predicted for ETEC0486 by TMHMM2.0 at aa 13-35, 50-69, 82-104, 109-131, 144-166, 176-195, 223-245, 260-282, 287-309, 319-341, 354-376, 380-402, 423-445 and 458-480
316401001849	Signal peptide predicted for ETEC0486 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.787 between residues 37 and 38
316401001850	hypothetical protein; Provisional; Region: PRK11627
316401001851	Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923
316401001852	Signal peptide predicted for ETEC0487 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.996 between residues 19 and 20
316401001853	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401001854	transcriptional regulator BolA; Provisional; Region: PRK11628
316401001855	trigger factor; Provisional; Region: tig; PRK01490
316401001856	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
316401001857	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
316401001858	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
316401001859	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
316401001860	oligomer interface [polypeptide binding]; other site
316401001861	active site residues [active]
316401001862	PS00381 Endopeptidase Clp serine active site.
316401001863	PS00382 Endopeptidase Clp histidine active site.
316401001864	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
316401001865	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
316401001866	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316401001867	Walker A motif; other site
316401001868	ATP binding site [chemical binding]; other site
316401001869	Walker B motif; other site
316401001870	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
316401001871	PS00017 ATP/GTP-binding site motif A (P-loop).
316401001872	DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787
316401001873	Found in ATP-dependent protease La (LON); Region: LON; smart00464
316401001874	Found in ATP-dependent protease La (LON); Region: LON; smart00464
316401001875	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316401001876	Walker A motif; other site
316401001877	ATP binding site [chemical binding]; other site
316401001878	Walker B motif; other site
316401001879	arginine finger; other site
316401001880	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
316401001881	PS00178 Aminoacyl-transfer RNA synthetases class-I signature.
316401001882	PS00017 ATP/GTP-binding site motif A (P-loop).
316401001883	PS01046 ATP-dependent serine proteases, lon family, serine active site.
316401001884	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
316401001885	IHF dimer interface [polypeptide binding]; other site
316401001886	IHF - DNA interface [nucleotide binding]; other site
316401001887	PS00045 Bacterial histone-like DNA-binding proteins signature.
316401001888	periplasmic folding chaperone; Provisional; Region: PRK10788
316401001889	SurA N-terminal domain; Region: SurA_N_3; cl07813
316401001890	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
316401001891	1 probable transmembrane helix predicted for ETEC0494 by TMHMM2.0 at aa 13-35
316401001892	PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature.
316401001893	competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426
316401001894	Signal peptide predicted for ETEC0495 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.994 between residues 25 and 26
316401001895	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
316401001896	active site
316401001897	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
316401001898	Ligand Binding Site [chemical binding]; other site
316401001899	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
316401001900	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
316401001901	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
316401001902	thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126
316401001903	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
316401001904	active site
316401001905	motif I; other site
316401001906	motif II; other site
316401001907	PS01228 Hypothetical cof family signature 1.
316401001908	PS01229 Hypothetical cof family signature 2.
316401001909	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
316401001910	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
316401001911	putative DNA binding site [nucleotide binding]; other site
316401001912	putative Zn2+ binding site [ion binding]; other site
316401001913	AsnC family; Region: AsnC_trans_reg; pfam01037
316401001914	PS00519 Bacterial regulatory proteins, asnC family signature.
316401001915	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
316401001916	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
316401001917	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316401001918	Walker A/P-loop; other site
316401001919	ATP binding site [chemical binding]; other site
316401001920	Q-loop/lid; other site
316401001921	ABC transporter signature motif; other site
316401001922	Walker B; other site
316401001923	D-loop; other site
316401001924	H-loop/switch region; other site
316401001925	6 probable transmembrane helices predicted for ETEC0501 by TMHMM2.0 at aa 21-43, 58-77, 129-151, 156-175, 246-268 and 278-300
316401001926	PS00017 ATP/GTP-binding site motif A (P-loop).
316401001927	PS00211 ABC transporters family signature.
316401001928	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790
316401001929	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
316401001930	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
316401001931	Walker A/P-loop; other site
316401001932	ATP binding site [chemical binding]; other site
316401001933	Q-loop/lid; other site
316401001934	ABC transporter signature motif; other site
316401001935	Walker B; other site
316401001936	D-loop; other site
316401001937	H-loop/switch region; other site
316401001938	Signal peptide predicted for ETEC0502 by SignalP 2.0 HMM (Signal peptide probability 0.978) with cleavage site probability 0.624 between residues 37 and 38
316401001939	4 probable transmembrane helices predicted for ETEC0502 by TMHMM2.0 at aa 28-50, 63-85, 163-185 and 249-271
316401001940	PS00017 ATP/GTP-binding site motif A (P-loop).
316401001941	PS00211 ABC transporters family signature.
316401001942	nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665
316401001943	Nitrogen regulatory protein P-II; Region: P-II; smart00938
316401001944	PS00496 P-II protein urydylation site.
316401001945	PS00638 P-II protein C-terminal region signature.
316401001946	ammonium transporter; Provisional; Region: PRK10666
316401001947	Signal peptide predicted for ETEC0504 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.553 between residues 27 and 28
316401001948	12 probable transmembrane helices predicted for ETEC0504 by TMHMM2.0 at aa 9-26, 36-58, 63-85, 120-142, 149-171, 186-205, 218-237, 247-269, 281-303, 307-324, 337-359 and 374-396
316401001949	PS01219 Ammonium transporters signature.
316401001950	acyl-CoA thioesterase II; Provisional; Region: PRK10526
316401001951	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
316401001952	active site
316401001953	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
316401001954	catalytic triad [active]
316401001955	dimer interface [polypeptide binding]; other site
316401001956	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126
316401001957	Signal peptide predicted for ETEC0506 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.963 between residues 20 and 21
316401001958	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401001959	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
316401001960	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
316401001961	DNA binding site [nucleotide binding]
316401001962	active site
316401001963	Uncharacterized conserved protein [Function unknown]; Region: COG5507
316401001964	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
316401001965	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
316401001966	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
316401001967	2 probable transmembrane helices predicted for ETEC0509 by TMHMM2.0 at aa 7-29 and 243-265
316401001968	Signal peptide predicted for ETEC0509 by SignalP 2.0 HMM (Signal peptide probability 0.772) with cleavage site probability 0.598 between residues 31 and 32
316401001969	sigma70 family sigma factor YlaC; Region: YlaC; pfam10777
316401001970	2 probable transmembrane helices predicted for ETEC0510 by TMHMM2.0 at aa 36-55 and 60-79
316401001971	maltose O-acetyltransferase; Provisional; Region: PRK10092
316401001972	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
316401001973	active site
316401001974	substrate binding site [chemical binding]; other site
316401001975	trimer interface [polypeptide binding]; other site
316401001976	CoA binding site [chemical binding]; other site
316401001977	PS00101 Hexapeptide-repeat containing-transferases signature.
316401001978	gene expression modulator; Provisional; Region: PRK10945
316401001979	Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757
316401001980	multidrug efflux system protein AcrB; Provisional; Region: PRK15127
316401001981	Protein export membrane protein; Region: SecD_SecF; cl14618
316401001982	Protein export membrane protein; Region: SecD_SecF; cl14618
316401001983	11 probable transmembrane helices predicted for ETEC0514 by TMHMM2.0 at aa 10-32, 340-359, 369-391, 438-460, 470-492, 542-564, 873-892, 899-921, 926-948, 975-997 and 1007-1029
316401001984	PS00017 ATP/GTP-binding site motif A (P-loop).
316401001985	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
316401001986	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
316401001987	HlyD family secretion protein; Region: HlyD_3; pfam13437
316401001988	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401001989	Signal peptide predicted for ETEC0515 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.716 between residues 24 and 25
316401001990	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
316401001991	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
316401001992	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
316401001993	PS01081 Bacterial regulatory proteins, tetR family signature.
316401001994	hypothetical protein; Provisional; Region: PRK11281
316401001995	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
316401001996	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
316401001997	Mechanosensitive ion channel; Region: MS_channel; pfam00924
316401001998	Signal peptide predicted for ETEC0517 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.887 between residues 33 and 34
316401001999	12 probable transmembrane helices predicted for ETEC0517 by TMHMM2.0 at aa 13-32, 500-522, 557-579, 584-606, 630-647, 658-680, 693-715, 725-747, 795-817, 837-859, 880-902 and 917-939
316401002000	PS01246 Uncharacterized protein family UPF0003 signature.
316401002001	hypothetical protein; Provisional; Region: PRK11038
316401002002	primosomal replication protein N''; Provisional; Region: PRK10093
316401002003	hypothetical protein; Provisional; Region: PRK10527
316401002004	4 probable transmembrane helices predicted for ETEC0520 by TMHMM2.0 at aa 7-26, 46-63, 75-92 and 96-118
316401002005	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
316401002006	active site
316401002007	PS00103 Purine/pyrimidine phosphoribosyl transferases signature.
316401002008	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
316401002009	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316401002010	Walker A motif; other site
316401002011	ATP binding site [chemical binding]; other site
316401002012	Walker B motif; other site
316401002013	DNA polymerase III subunit delta'; Validated; Region: PRK08485
316401002014	arginine finger; other site
316401002015	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
316401002016	DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168
316401002017	DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170
316401002018	PS00017 ATP/GTP-binding site motif A (P-loop).
316401002019	PS00215 Mitochondrial energy transfer proteins signature.
316401002020	hypothetical protein; Validated; Region: PRK00153
316401002021	Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353
316401002022	RecR protein; Region: RecR; pfam02132
316401002023	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
316401002024	putative active site [active]
316401002025	putative metal-binding site [ion binding]; other site
316401002026	tetramer interface [polypeptide binding]; other site
316401002027	PS01300 RecR protein signature.
316401002028	heat shock protein 90; Provisional; Region: PRK05218
316401002029	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316401002030	ATP binding site [chemical binding]; other site
316401002031	Mg2+ binding site [ion binding]; other site
316401002032	G-X-G motif; other site
316401002033	PS00298 Heat shock hsp90 proteins family signature.
316401002034	adenylate kinase; Reviewed; Region: adk; PRK00279
316401002035	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
316401002036	AMP-binding site [chemical binding]; other site
316401002037	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
316401002038	PS00113 Adenylate kinase signature.
316401002039	ferrochelatase; Region: hemH; TIGR00109
316401002040	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
316401002041	C-terminal domain interface [polypeptide binding]; other site
316401002042	active site
316401002043	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
316401002044	active site
316401002045	N-terminal domain interface [polypeptide binding]; other site
316401002046	PS00534 Ferrochelatase signature.
316401002047	acetyl esterase; Provisional; Region: PRK10162
316401002048	PS01174 Lipolytic enzymes G-D-X-G family, putative serine active site.
316401002049	PS01173 Lipolytic enzymes G-D-X-G family, putative histidine active site.
316401002050	inosine/guanosine kinase; Provisional; Region: PRK15074
316401002051	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
316401002052	PS00584 pfkB family of carbohydrate kinases signature 2.
316401002053	putative cation:proton antiport protein; Provisional; Region: PRK10669
316401002054	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
316401002055	TrkA-N domain; Region: TrkA_N; pfam02254
316401002056	12 probable transmembrane helices predicted for ETEC0530 by TMHMM2.0 at aa 4-26, 33-52, 56-78, 87-109, 114-136, 149-171, 184-206, 226-248, 280-299, 302-324, 339-361 and 368-387
316401002057	PS00017 ATP/GTP-binding site motif A (P-loop).
316401002058	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401002059	Major Facilitator Superfamily; Region: MFS_1; pfam07690
316401002060	putative substrate translocation pore; other site
316401002061	10 probable transmembrane helices predicted for ETEC0531 by TMHMM2.0 at aa 26-48, 58-80, 101-123, 180-202, 223-245, 265-287, 294-313, 317-339, 351-373 and 377-399
316401002062	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558
316401002063	Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405
316401002064	active site
316401002065	metal binding site [ion binding]; metal-binding site
316401002066	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
316401002067	Signal peptide predicted for ETEC0532 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.995 between residues 25 and 26
316401002068	PS00785 5'-nucleotidase signature 1.
316401002069	PS00786 5'-nucleotidase signature 2.
316401002070	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
316401002071	putative deacylase active site [active]
316401002072	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735
316401002073	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
316401002074	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
316401002075	non-specific DNA binding site [nucleotide binding]; other site
316401002076	salt bridge; other site
316401002077	sequence-specific DNA binding site [nucleotide binding]; other site
316401002078	copper exporting ATPase; Provisional; Region: copA; PRK10671
316401002079	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
316401002080	metal-binding site [ion binding]
316401002081	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
316401002082	metal-binding site [ion binding]
316401002083	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
316401002084	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
316401002085	motif II; other site
316401002086	8 probable transmembrane helices predicted for ETEC0536 by TMHMM2.0 at aa 189-206, 216-238, 245-267, 282-299, 436-458, 463-485, 778-797 and 802-824
316401002087	PS01229 Hypothetical cof family signature 2.
316401002088	PS00154 E1-E2 ATPases phosphorylation site.
316401002089	PS01047 Heavy-metal-associated domain.
316401002090	glutaminase; Reviewed; Region: PRK12356
316401002091	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
316401002092	amino acid transporter; Region: 2A0306; TIGR00909
316401002093	12 probable transmembrane helices predicted for ETEC0538 by TMHMM2.0 at aa 13-35, 45-67, 88-110, 130-149, 156-178, 193-215, 228-250, 278-300, 321-343, 348-367, 374-396 and 406-423
316401002094	PS00041 Bacterial regulatory proteins, araC family signature.
316401002095	DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227
316401002096	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
316401002097	DNA binding residues [nucleotide binding]
316401002098	dimer interface [polypeptide binding]; other site
316401002099	copper binding site [ion binding]; other site
316401002100	PS00552 Bacterial regulatory proteins, merR family signature.
316401002101	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
316401002102	3 probable transmembrane helices predicted for ETEC0540 by TMHMM2.0 at aa 5-22, 29-48 and 52-74
316401002103	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
316401002104	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
316401002105	PS01270 Band 7 protein family signature.
316401002106	1 probable transmembrane helix predicted for ETEC0541 by TMHMM2.0 at aa 7-29
316401002107	putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247
316401002108	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316401002109	Walker A/P-loop; other site
316401002110	ATP binding site [chemical binding]; other site
316401002111	Q-loop/lid; other site
316401002112	ABC transporter signature motif; other site
316401002113	Walker B; other site
316401002114	D-loop; other site
316401002115	H-loop/switch region; other site
316401002116	PS00017 ATP/GTP-binding site motif A (P-loop).
316401002117	PS00211 ABC transporters family signature.
316401002118	Uncharacterized protein family (UPF0014); Region: UPF0014; pfam03649
316401002119	Signal peptide predicted for ETEC0543 by SignalP 2.0 HMM (Signal peptide probability 0.716) with cleavage site probability 0.611 between residues 27 and 28
316401002120	7 probable transmembrane helices predicted for ETEC0543 by TMHMM2.0 at aa 5-24, 36-58, 63-80, 92-114, 124-146, 192-209 and 219-241
316401002121	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
316401002122	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
316401002123	oxidoreductase; Provisional; Region: PRK08017
316401002124	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
316401002125	NADP binding site [chemical binding]; other site
316401002126	active site
316401002127	steroid binding site; other site
316401002128	PS00061 Short-chain dehydrogenases/reductases family signature.
316401002129	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
316401002130	active site
316401002131	catalytic triad [active]
316401002132	oxyanion hole [active]
316401002133	switch loop; other site
316401002134	PS01098 Lipolytic enzymes G-D-S-L family, serine active site.
316401002135	1 probable transmembrane helix predicted for ETEC0546 by TMHMM2.0 at aa 12-34
316401002136	Signal peptide predicted for ETEC0546 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.788 between residues 26 and 27
316401002137	putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584
316401002138	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
316401002139	Walker A/P-loop; other site
316401002140	ATP binding site [chemical binding]; other site
316401002141	Q-loop/lid; other site
316401002142	ABC transporter signature motif; other site
316401002143	Walker B; other site
316401002144	D-loop; other site
316401002145	H-loop/switch region; other site
316401002146	PS00017 ATP/GTP-binding site motif A (P-loop).
316401002147	PS00211 ABC transporters family signature.
316401002148	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
316401002149	FtsX-like permease family; Region: FtsX; pfam02687
316401002150	FtsX-like permease family; Region: FtsX; pfam02687
316401002151	Signal peptide predicted for ETEC0548 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.585 between residues 33 and 34
316401002152	10 probable transmembrane helices predicted for ETEC0548 by TMHMM2.0 at aa 13-35, 243-262, 291-313, 333-355, 376-398, 403-425, 451-473, 676-698, 732-754 and 769-791
316401002153	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401002154	PAAR motif; Region: PAAR_motif; cl15808
316401002155	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
316401002156	RHS Repeat; Region: RHS_repeat; pfam05593
316401002157	RHS Repeat; Region: RHS_repeat; pfam05593
316401002158	RHS Repeat; Region: RHS_repeat; pfam05593
316401002159	RHS Repeat; Region: RHS_repeat; pfam05593
316401002160	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
316401002161	RHS Repeat; Region: RHS_repeat; pfam05593
316401002162	RHS Repeat; Region: RHS_repeat; pfam05593
316401002163	RHS protein; Region: RHS; pfam03527
316401002164	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
316401002165	Domain of unknown function (DUF4329); Region: DUF4329; pfam14220
316401002166	Signal peptide predicted for ETEC0550 by SignalP 2.0 HMM (Signal peptide probability 0.932) with cleavage site probability 0.376 between residues 17 and 18
316401002167	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401002168	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
316401002169	RHS protein; Region: RHS; pfam03527
316401002170	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
316401002171	hypothetical protein; Provisional; Region: PRK14710
316401002172	eIF3G domain found in eukaryotic translation initiation factor 3 subunit G (eIF-3G) and similar proteins; Region: eIF3G; cl13749
316401002173	1 probable transmembrane helix predicted for ETEC0552 by TMHMM2.0 at aa 11-33
316401002174	Transposase; Region: HTH_Tnp_1; pfam01527
316401002175	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
316401002176	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
316401002177	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
316401002178	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
316401002179	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
316401002180	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
316401002181	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
316401002182	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
316401002183	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
316401002184	1 probable transmembrane helix predicted for ETEC0554A by TMHMM2.0 at aa 34-51
316401002185	Winged helix-turn helix; Region: HTH_29; pfam13551
316401002186	Helix-turn-helix domain; Region: HTH_28; pfam13518
316401002187	Predicted ATPase [General function prediction only]; Region: COG2603
316401002188	Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520
316401002189	active site residue [active]
316401002190	PS00017 ATP/GTP-binding site motif A (P-loop).
316401002191	DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094
316401002192	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401002193	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
316401002194	dimerization interface [polypeptide binding]; other site
316401002195	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
316401002196	ureidoglycolate hydrolase; Provisional; Region: PRK03606
316401002197	DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163
316401002198	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
316401002199	Bacterial transcriptional regulator; Region: IclR; pfam01614
316401002200	PS01051 Bacterial regulatory proteins, iclR family signature.
316401002201	glyoxylate carboligase; Provisional; Region: PRK11269
316401002202	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
316401002203	PYR/PP interface [polypeptide binding]; other site
316401002204	dimer interface [polypeptide binding]; other site
316401002205	TPP binding site [chemical binding]; other site
316401002206	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
316401002207	Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006
316401002208	TPP-binding site [chemical binding]; other site
316401002209	hydroxypyruvate isomerase; Provisional; Region: PRK09997
316401002210	tartronate semialdehyde reductase; Provisional; Region: PRK15059
316401002211	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
316401002212	PS00895 3-hydroxyisobutyrate dehydrogenase signature.
316401002213	nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; Region: SLC-NCS1sbd; cd10323
316401002214	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
316401002215	Na binding site [ion binding]; other site
316401002216	substrate binding site [chemical binding]; other site
316401002217	12 probable transmembrane helices predicted for ETEC0563 by TMHMM2.0 at aa 51-73, 88-110, 117-139, 154-176, 189-211, 226-248, 268-290, 310-332, 345-367, 377-399, 420-439 and 449-468
316401002218	allantoinase; Provisional; Region: PRK08044
316401002219	L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315
316401002220	active site
316401002221	putative uracil/xanthine transporter; Provisional; Region: PRK11412
316401002222	PS00430 TonB-dependent receptor proteins signature 1.
316401002223	12 probable transmembrane helices predicted for ETEC0565 by TMHMM2.0 at aa 15-36, 43-65, 100-122, 129-151, 171-190, 197-214, 229-251, 281-303, 318-340, 347-366, 376-398 and 405-427
316401002224	glycerate kinase II; Provisional; Region: PRK09932
316401002225	PS00017 ATP/GTP-binding site motif A (P-loop).
316401002226	Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257
316401002227	Protein of unknown function (DUF861); Region: Cupin_3; pfam05899
316401002228	Cupin domain; Region: Cupin_2; cl17218
316401002229	allantoate amidohydrolase; Region: AllC; TIGR03176
316401002230	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
316401002231	active site
316401002232	metal binding site [ion binding]; metal-binding site
316401002233	dimer interface [polypeptide binding]; other site
316401002234	ureidoglycolate dehydrogenase; Provisional; Region: PRK15025
316401002235	membrane protein FdrA; Validated; Region: PRK06091
316401002236	CoA binding domain; Region: CoA_binding; pfam02629
316401002237	CoA-ligase; Region: Ligase_CoA; pfam00549
316401002238	Protein of unknown function (DUF1116); Region: DUF1116; pfam06545
316401002239	Protein of unknown function (DUF2877); Region: DUF2877; pfam11392
316401002240	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
316401002241	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
316401002242	putative substrate binding site [chemical binding]; other site
316401002243	nucleotide binding site [chemical binding]; other site
316401002244	nucleotide binding site [chemical binding]; other site
316401002245	homodimer interface [polypeptide binding]; other site
316401002246	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
316401002247	ATP-grasp domain; Region: ATP-grasp; pfam02222
316401002248	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
316401002249	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
316401002250	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
316401002251	putative active site [active]
316401002252	putative metal binding site [ion binding]; other site
316401002253	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
316401002254	substrate binding site [chemical binding]; other site
316401002255	PS00170 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature.
316401002256	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
316401002257	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
316401002258	active site
316401002259	HIGH motif; other site
316401002260	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
316401002261	KMSKS motif; other site
316401002262	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
316401002263	tRNA binding surface [nucleotide binding]; other site
316401002264	anticodon binding site; other site
316401002265	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
316401002266	4 probable transmembrane helices predicted for ETEC0579 by TMHMM2.0 at aa 13-35, 55-77, 84-103 and 148-170
316401002267	ribosome-associated protein; Provisional; Region: PRK11507
316401002268	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
316401002269	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
316401002270	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
316401002271	homodimer interface [polypeptide binding]; other site
316401002272	NADP binding site [chemical binding]; other site
316401002273	substrate binding site [chemical binding]; other site
316401002274	PS00767 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2.
316401002275	PS00766 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 1.
316401002276	PS00017 ATP/GTP-binding site motif A (P-loop).
316401002277	type-1 fimbrial protein subunit A; Provisional; Region: PRK15194
316401002278	Signal peptide predicted for ETEC0582 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.985 between residues 22 and 23
316401002279	fimbrial chaperone protein FimC; Provisional; Region: PRK15195
316401002280	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
316401002281	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
316401002282	Signal peptide predicted for ETEC0583 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 23 and 24
316401002283	1 probable transmembrane helix predicted for ETEC0583 by TMHMM2.0 at aa 7-29
316401002284	PS00635 Gram-negative pili assembly chaperone signature.
316401002285	This CDS has been interrupted by an insertion element protein
316401002286	IS1 transposase; Region: DDE_Tnp_IS1; pfam03400
316401002287	fimbrial-like adhesin; Provisional; Region: fimH; PRK15199
316401002288	fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934
316401002289	Signal peptide predicted for ETEC0587 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 20 and 21
316401002290	transcriptional regulator FimZ; Provisional; Region: PRK09935
316401002291	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316401002292	active site
316401002293	phosphorylation site [posttranslational modification]
316401002294	intermolecular recognition site; other site
316401002295	dimerization interface [polypeptide binding]; other site
316401002296	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
316401002297	DNA binding residues [nucleotide binding]
316401002298	dimerization interface [polypeptide binding]; other site
316401002299	PS00622 Bacterial regulatory proteins, luxR family signature.
316401002300	DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978
316401002301	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316401002302	PS00041 Bacterial regulatory proteins, araC family signature.
316401002303	hypothetical protein; Provisional; Region: PRK09936
316401002304	1 probable transmembrane helix predicted for ETEC0590 by TMHMM2.0 at aa 4-26
316401002305	Signal peptide predicted for ETEC0590 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.967 between residues 20 and 21
316401002306	bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782
316401002307	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
316401002308	TPR motif; other site
316401002309	binding surface
316401002310	Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283
316401002311	PS00017 ATP/GTP-binding site motif A (P-loop).
316401002312	PS00017 ATP/GTP-binding site motif A (P-loop).
316401002313	Signal peptide predicted for ETEC0591 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 27 and 28
316401002314	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234
316401002315	active site
316401002316	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
316401002317	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
316401002318	4 probable transmembrane helices predicted for ETEC0592 by TMHMM2.0 at aa 20-42, 361-383, 393-415 and 422-444
316401002319	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
316401002320	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
316401002321	Transposase [DNA replication, recombination, and repair]; Region: COG5433
316401002322	Transposase [DNA replication, recombination, and repair]; Region: COG5433
316401002323	PAAR motif; Region: PAAR_motif; pfam05488
316401002324	RHS Repeat; Region: RHS_repeat; cl11982
316401002325	RHS Repeat; Region: RHS_repeat; pfam05593
316401002326	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
316401002327	RHS Repeat; Region: RHS_repeat; pfam05593
316401002328	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
316401002329	RHS Repeat; Region: RHS_repeat; pfam05593
316401002330	RHS Repeat; Region: RHS_repeat; cl11982
316401002331	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
316401002332	PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1.
316401002333	Uncharacterized conserved protein [Function unknown]; Region: COG5435
316401002334	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
316401002335	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
316401002336	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
316401002337	sensor kinase CusS; Provisional; Region: PRK09835
316401002338	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
316401002339	dimerization interface [polypeptide binding]; other site
316401002340	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316401002341	dimer interface [polypeptide binding]; other site
316401002342	phosphorylation site [posttranslational modification]
316401002343	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316401002344	ATP binding site [chemical binding]; other site
316401002345	Mg2+ binding site [ion binding]; other site
316401002346	G-X-G motif; other site
316401002347	2 probable transmembrane helices predicted for ETEC0598 by TMHMM2.0 at aa 15-37 and 187-206
316401002348	Signal peptide predicted for ETEC0598 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.995 between residues 32 and 33
316401002349	DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836
316401002350	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316401002351	active site
316401002352	phosphorylation site [posttranslational modification]
316401002353	intermolecular recognition site; other site
316401002354	dimerization interface [polypeptide binding]; other site
316401002355	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
316401002356	DNA binding site [nucleotide binding]
316401002357	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
316401002358	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401002359	periplasmic copper-binding protein; Provisional; Region: PRK09838
316401002360	Signal peptide predicted for ETEC0601 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.996 between residues 22 and 23
316401002361	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
316401002362	HlyD family secretion protein; Region: HlyD_3; pfam13437
316401002363	Signal peptide predicted for ETEC0602 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.631 between residues 28 and 29
316401002364	1 probable transmembrane helix predicted for ETEC0602 by TMHMM2.0 at aa 7-26
316401002365	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
316401002366	12 probable transmembrane helices predicted for ETEC0603 by TMHMM2.0 at aa 13-32, 342-359, 364-386, 390-412, 446-468, 483-505, 532-554, 874-891, 898-920, 924-946, 985-1002 and 1012-1034
316401002367	PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature.
316401002368	phenylalanine transporter; Provisional; Region: PRK10249
316401002369	12 probable transmembrane helices predicted for ETEC0604 by TMHMM2.0 at aa 30-49, 53-70, 98-120, 135-157, 162-184, 206-228, 249-271, 291-313, 340-362, 366-388, 408-430 and 435-452
316401002370	PS00218 Amino acid permeases signature.
316401002371	PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1.
316401002372	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
316401002373	Mechanosensitive ion channel; Region: MS_channel; pfam00924
316401002374	5 probable transmembrane helices predicted for ETEC0605 by TMHMM2.0 at aa 23-45, 68-90, 105-127, 140-162 and 172-194
316401002375	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
316401002376	dimer interface [polypeptide binding]; other site
316401002377	FMN binding site [chemical binding]; other site
316401002378	hypothetical protein; Provisional; Region: PRK10250
316401002379	Protein of unknown function (DUF1158); Region: DUF1158; pfam06643
316401002380	2 probable transmembrane helices predicted for ETEC0608 by TMHMM2.0 at aa 13-35 and 50-72
316401002381	Signal peptide predicted for ETEC0608 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.975 between residues 31 and 32
316401002382	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401002383	gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516
316401002384	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
316401002385	Hok/gef family; Region: HOK_GEF; pfam01848
316401002386	Signal peptide predicted for ETEC0610 by SignalP 2.0 HMM (Signal peptide probability 0.990) with cleavage site probability 0.531 between residues 24 and 25
316401002387	1 probable transmembrane helix predicted for ETEC0610 by TMHMM2.0 at aa 5-24
316401002388	PS00556 Hok/gef family cell toxic proteins signature.
316401002389	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
316401002390	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
316401002391	phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251
316401002392	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
316401002393	outer membrane receptor FepA; Provisional; Region: PRK13524
316401002394	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
316401002395	N-terminal plug; other site
316401002396	ligand-binding site [chemical binding]; other site
316401002397	PS01156 TonB-dependent receptor proteins signature 2.
316401002398	PS00430 TonB-dependent receptor proteins signature 1.
316401002399	Signal peptide predicted for ETEC0613 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 22 and 23
316401002400	enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439
316401002401	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
316401002402	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
316401002403	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251
316401002404	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
316401002405	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
316401002406	acyl-activating enzyme (AAE) consensus motif; other site
316401002407	AMP binding site [chemical binding]; other site
316401002408	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
316401002409	PS00455 Putative AMP-binding domain signature.
316401002410	PS00012 Phosphopantetheine attachment site.
316401002411	LPS O-antigen length regulator; Provisional; Region: PRK10381
316401002412	Chain length determinant protein; Region: Wzz; pfam02706
316401002413	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
316401002414	2 probable transmembrane helices predicted for ETEC0617 by TMHMM2.0 at aa 43-62 and 339-361
316401002415	iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253
316401002416	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
316401002417	Walker A/P-loop; other site
316401002418	ATP binding site [chemical binding]; other site
316401002419	Q-loop/lid; other site
316401002420	ABC transporter signature motif; other site
316401002421	Walker B; other site
316401002422	D-loop; other site
316401002423	H-loop/switch region; other site
316401002424	PS00211 ABC transporters family signature.
316401002425	PS00017 ATP/GTP-binding site motif A (P-loop).
316401002426	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
316401002427	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
316401002428	ABC-ATPase subunit  interface; other site
316401002429	dimer interface [polypeptide binding]; other site
316401002430	putative PBP binding regions; other site
316401002431	8 probable transmembrane helices predicted for ETEC0619 by TMHMM2.0 at aa 7-29, 58-80, 93-112, 116-138, 145-167, 187-209, 240-262 and 302-324
316401002432	Signal peptide predicted for ETEC0619 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.844 between residues 22 and 23
316401002433	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
316401002434	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
316401002435	ABC-ATPase subunit  interface; other site
316401002436	dimer interface [polypeptide binding]; other site
316401002437	putative PBP binding regions; other site
316401002438	9 probable transmembrane helices predicted for ETEC0620 by TMHMM2.0 at aa 10-32, 65-84, 94-116, 121-140, 150-172, 193-215, 240-262, 282-304 and 308-326
316401002439	Signal peptide predicted for ETEC0620 by SignalP 2.0 HMM (Signal peptide probability 0.661) with cleavage site probability 0.469 between residues 32 and 33
316401002440	enterobactin exporter EntS; Provisional; Region: PRK10489
316401002441	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401002442	putative substrate translocation pore; other site
316401002443	11 probable transmembrane helices predicted for ETEC0621 by TMHMM2.0 at aa 20-42, 54-76, 86-104, 111-133, 148-170, 177-199, 214-236, 256-278, 288-307, 314-336 and 377-399
316401002444	iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957
316401002445	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
316401002446	siderophore binding site; other site
316401002447	Signal peptide predicted for ETEC0622 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.990 between residues 26 and 27
316401002448	isochorismate synthase EntC; Provisional; Region: PRK15016
316401002449	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
316401002450	enterobactin synthase subunit E; Provisional; Region: entE; PRK10946
316401002451	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
316401002452	acyl-activating enzyme (AAE) consensus motif; other site
316401002453	active site
316401002454	AMP binding site [chemical binding]; other site
316401002455	substrate binding site [chemical binding]; other site
316401002456	PS00455 Putative AMP-binding domain signature.
316401002457	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
316401002458	hydrophobic substrate binding pocket; other site
316401002459	Isochorismatase family; Region: Isochorismatase; pfam00857
316401002460	active site
316401002461	conserved cis-peptide bond; other site
316401002462	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
316401002463	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
316401002464	2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331
316401002465	putative NAD(P) binding site [chemical binding]; other site
316401002466	active site
316401002467	PS00061 Short-chain dehydrogenases/reductases family signature.
316401002468	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
316401002469	CoenzymeA binding site [chemical binding]; other site
316401002470	subunit interaction site [polypeptide binding]; other site
316401002471	PHB binding site; other site
316401002472	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
316401002473	Carbon starvation protein CstA; Region: CstA; pfam02554
316401002474	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
316401002475	Signal peptide predicted for ETEC0628 by SignalP 2.0 HMM (Signal peptide probability 0.848) with cleavage site probability 0.539 between residues 22 and 23
316401002476	17 probable transmembrane helices predicted for ETEC0628 by TMHMM2.0 at aa 7-26, 32-54, 89-111, 116-138, 159-181, 191-213, 218-240, 255-277, 284-306, 326-348, 361-383, 398-420, 441-463, 468-487, 514-533, 548-570 and 577-599
316401002477	carbon starvation protein A; Provisional; Region: PRK15015
316401002478	1 probable transmembrane helix predicted for cstA by TMHMM2.0 at aa 30-52
316401002479	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
316401002480	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
316401002481	putative active site [active]
316401002482	metal binding site [ion binding]; metal-binding site
316401002483	PS00913 Iron-containing alcohol dehydrogenases signature 1.
316401002484	methionine aminotransferase; Validated; Region: PRK09082
316401002485	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
316401002486	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316401002487	homodimer interface [polypeptide binding]; other site
316401002488	catalytic residue [active]
316401002489	PS00017 ATP/GTP-binding site motif A (P-loop).
316401002490	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
316401002491	ParB-like nuclease domain; Region: ParBc; pfam02195
316401002492	Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969
316401002493	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
316401002494	Active Sites [active]
316401002495	Domain of unknown function (DUF3440); Region: DUF3440; pfam11922
316401002496	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482
316401002497	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401002498	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
316401002499	PS00044 Bacterial regulatory proteins, lysR family signature.
316401002500	disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657
316401002501	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
316401002502	dimerization domain [polypeptide binding]; other site
316401002503	dimer interface [polypeptide binding]; other site
316401002504	catalytic residues [active]
316401002505	Signal peptide predicted for ETEC0634 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 17 and 18
316401002506	alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382
316401002507	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
316401002508	dimer interface [polypeptide binding]; other site
316401002509	decamer (pentamer of dimers) interface [polypeptide binding]; other site
316401002510	catalytic triad [active]
316401002511	peroxidatic and resolving cysteines [active]
316401002512	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
316401002513	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
316401002514	catalytic residue [active]
316401002515	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
316401002516	catalytic residues [active]
316401002517	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
316401002518	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
316401002519	PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site.
316401002520	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
316401002521	Ligand Binding Site [chemical binding]; other site
316401002522	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
316401002523	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
316401002524	NAD binding site [chemical binding]; other site
316401002525	catalytic Zn binding site [ion binding]; other site
316401002526	structural Zn binding site [ion binding]; other site
316401002527	PS00059 Zinc-containing alcohol dehydrogenases signature.
316401002528	1 probable transmembrane helix predicted for ETEC0638A by TMHMM2.0 at aa 36-58
316401002529	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
316401002530	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
316401002531	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
316401002532	B1 nucleotide binding pocket [chemical binding]; other site
316401002533	B2 nucleotide binding pocket [chemical binding]; other site
316401002534	CAS motifs; other site
316401002535	active site
316401002536	PS00531 Ribonuclease T2 family histidine active site 2.
316401002537	PS00530 Ribonuclease T2 family histidine active site 1.
316401002538	Signal peptide predicted for ETEC0640 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.627 between residues 25 and 26
316401002539	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
316401002540	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
316401002541	transmembrane helices; other site
316401002542	13 probable transmembrane helices predicted for ETEC0641 by TMHMM2.0 at aa 7-24, 34-53, 58-75, 95-117, 138-157, 198-220, 233-255, 288-305, 307-329, 339-361, 374-396, 428-450 and 463-485
316401002543	triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096
316401002544	Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697
316401002545	PS00017 ATP/GTP-binding site motif A (P-loop).
316401002546	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
316401002547	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
316401002548	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
316401002549	Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053
316401002550	Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169
316401002551	putative active site [active]
316401002552	(T/H)XGH motif; other site
316401002553	sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053
316401002554	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316401002555	putative active site [active]
316401002556	heme pocket [chemical binding]; other site
316401002557	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316401002558	ATP binding site [chemical binding]; other site
316401002559	Mg2+ binding site [ion binding]; other site
316401002560	G-X-G motif; other site
316401002561	Signal peptide predicted for ETEC0648 by SignalP 2.0 HMM (Signal peptide probability 0.965) with cleavage site probability 0.848 between residues 38 and 39
316401002562	2 probable transmembrane helices predicted for ETEC0648 by TMHMM2.0 at aa 20-42 and 180-202
316401002563	two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046
316401002564	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316401002565	active site
316401002566	phosphorylation site [posttranslational modification]
316401002567	intermolecular recognition site; other site
316401002568	dimerization interface [polypeptide binding]; other site
316401002569	Transcriptional regulator; Region: CitT; pfam12431
316401002570	C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654
316401002571	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
316401002572	12 probable transmembrane helices predicted for ETEC0650 by TMHMM2.0 at aa 4-22, 29-46, 81-103, 124-146, 161-183, 196-218, 238-260, 267-289, 309-331, 343-365, 407-429 and 436-458
316401002573	phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045
316401002574	Signal peptide predicted for ETEC0651 by SignalP 2.0 HMM (Signal peptide probability 0.700) with cleavage site probability 0.674 between residues 25 and 26
316401002575	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
316401002576	DNA-binding site [nucleotide binding]; DNA binding site
316401002577	RNA-binding motif; other site
316401002578	PS00352 'Cold-shock' DNA-binding domain signature.
316401002579	chromosome condensation membrane protein; Provisional; Region: PRK14196
316401002580	4 probable transmembrane helices predicted for ETEC0653 by TMHMM2.0 at aa 4-23, 32-54, 69-91 and 98-120
316401002581	Predicted amidohydrolase [General function prediction only]; Region: COG0388
316401002582	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
316401002583	putative active site [active]
316401002584	catalytic triad [active]
316401002585	putative dimer interface [polypeptide binding]; other site
316401002586	PS01227 Uncharacterized protein family UPF0012 signature.
316401002587	twin arginine translocase protein E; Validated; Region: tatE; PRK03625
316401002588	1 probable transmembrane helix predicted for ETEC0655 by TMHMM2.0 at aa 4-21
316401002589	lipoyl synthase; Provisional; Region: PRK05481
316401002590	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316401002591	FeS/SAM binding site; other site
316401002592	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482
316401002593	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401002594	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
316401002595	substrate binding pocket [chemical binding]; other site
316401002596	dimerization interface [polypeptide binding]; other site
316401002597	PS00044 Bacterial regulatory proteins, lysR family signature.
316401002598	lipoate-protein ligase B; Provisional; Region: PRK14342
316401002599	PS01313 Lipoate-protein ligase B signature.
316401002600	hypothetical protein; Provisional; Region: PRK04998
316401002601	D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793
316401002602	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
316401002603	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
316401002604	Signal peptide predicted for ETEC0660 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 29 and 30
316401002605	rare lipoprotein A; Provisional; Region: PRK10672
316401002606	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
316401002607	Sporulation related domain; Region: SPOR; pfam05036
316401002608	Signal peptide predicted for ETEC0661 by SignalP 2.0 HMM (Signal peptide probability 0.991) with cleavage site probability 0.537 between residues 23 and 24
316401002609	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401002610	cell wall shape-determining protein; Provisional; Region: PRK10794
316401002611	9 probable transmembrane helices predicted for ETEC0662 by TMHMM2.0 at aa 15-37, 50-67, 77-99, 136-155, 160-179, 181-203, 272-294, 306-328 and 338-360
316401002612	PS00428 Cell cycle proteins ftsW / rodA / spoVE signature.
316401002613	Signal peptide predicted for ETEC0662 by SignalP 2.0 HMM (Signal peptide probability 0.913) with cleavage site probability 0.582 between residues 40 and 41
316401002614	penicillin-binding protein 2; Provisional; Region: PRK10795
316401002615	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
316401002616	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
316401002617	1 probable transmembrane helix predicted for ETEC0663 by TMHMM2.0 at aa 21-43
316401002618	rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246
316401002619	ribosome-associated protein; Provisional; Region: PRK11538
316401002620	PS00017 ATP/GTP-binding site motif A (P-loop).
316401002621	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
316401002622	catalytic core [active]
316401002623	PS00175 Phosphoglycerate mutase family phosphohistidine signature.
316401002624	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
316401002625	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
316401002626	active site
316401002627	(T/H)XGH motif; other site
316401002628	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
316401002629	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
316401002630	LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796
316401002631	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401002632	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
316401002633	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
316401002634	HIGH motif; other site
316401002635	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
316401002636	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
316401002637	active site
316401002638	KMSKS motif; other site
316401002639	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
316401002640	tRNA binding surface [nucleotide binding]; other site
316401002641	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
316401002642	PS00178 Aminoacyl-transfer RNA synthetases class-I signature.
316401002643	hypothetical protein; Provisional; Region: PRK11032
316401002644	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
316401002645	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
316401002646	Protein of unknown function (DUF433); Region: DUF433; cl01030
316401002647	MULE transposase domain; Region: MULE; pfam10551
316401002648	PS01007 Transposases, Mutator family, signature.
316401002649	Sel1-like repeats; Region: SEL1; smart00671
316401002650	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
316401002651	Sel1-like repeats; Region: SEL1; smart00671
316401002652	Sel1-like repeats; Region: SEL1; smart00671
316401002653	Sel1-like repeats; Region: SEL1; smart00671
316401002654	Sel1-like repeats; Region: SEL1; smart00671
316401002655	Sel1-like repeats; Region: SEL1; smart00671
316401002656	Sel1-like repeats; Region: SEL1; smart00671
316401002657	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
316401002658	DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271
316401002659	HSP70 interaction site [polypeptide binding]; other site
316401002660	1 probable transmembrane helix predicted for ETEC0675 by TMHMM2.0 at aa 451-473
316401002661	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
316401002662	Sel1-like repeats; Region: SEL1; smart00671
316401002663	Sel1-like repeats; Region: SEL1; smart00671
316401002664	Sel1-like repeats; Region: SEL1; smart00671
316401002665	1 probable transmembrane helix predicted for ETEC0676 by TMHMM2.0 at aa 5-22
316401002666	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
316401002667	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
316401002668	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
316401002669	Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235
316401002670	nucleotide binding site [chemical binding]; other site
316401002671	putative NEF/HSP70 interaction site [polypeptide binding]; other site
316401002672	SBD interface [polypeptide binding]; other site
316401002673	PS01036 Heat shock hsp70 proteins family signature 3.
316401002674	PS00329 Heat shock hsp70 proteins family signature 2.
316401002675	PS00297 Heat shock hsp70 proteins family signature 1.
316401002676	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
316401002677	active site
316401002678	tetramer interface [polypeptide binding]; other site
316401002679	PS01247 Inosine-uridine preferring nucleoside hydrolase family signature.
316401002680	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
316401002681	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
316401002682	Walker A/P-loop; other site
316401002683	ATP binding site [chemical binding]; other site
316401002684	Q-loop/lid; other site
316401002685	ABC transporter signature motif; other site
316401002686	Walker B; other site
316401002687	D-loop; other site
316401002688	H-loop/switch region; other site
316401002689	PS00211 ABC transporters family signature.
316401002690	PS00017 ATP/GTP-binding site motif A (P-loop).
316401002691	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
316401002692	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401002693	dimer interface [polypeptide binding]; other site
316401002694	conserved gate region; other site
316401002695	putative PBP binding loops; other site
316401002696	ABC-ATPase subunit interface; other site
316401002697	5 probable transmembrane helices predicted for ETEC0682 by TMHMM2.0 at aa 15-37, 58-80, 95-112, 155-177 and 197-219
316401002698	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
316401002699	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401002700	dimer interface [polypeptide binding]; other site
316401002701	conserved gate region; other site
316401002702	putative PBP binding loops; other site
316401002703	ABC-ATPase subunit interface; other site
316401002704	5 probable transmembrane helices predicted for ETEC0683 by TMHMM2.0 at aa 31-53, 66-88, 108-127, 179-196 and 211-233
316401002705	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
316401002706	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
316401002707	substrate binding pocket [chemical binding]; other site
316401002708	membrane-bound complex binding site; other site
316401002709	hinge residues; other site
316401002710	Signal peptide predicted for ETEC0684 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 22 and 23
316401002711	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
316401002712	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
316401002713	putative active site [active]
316401002714	catalytic triad [active]
316401002715	putative dimer interface [polypeptide binding]; other site
316401002716	6 probable transmembrane helices predicted for ETEC0685 by TMHMM2.0 at aa 12-34, 54-76, 89-111, 166-188, 195-213 and 489-507
316401002717	Signal peptide predicted for ETEC0685 by SignalP 2.0 HMM (Signal peptide probability 0.892) with cleavage site probability 0.838 between residues 27 and 28
316401002718	magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094
316401002719	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
316401002720	Transporter associated domain; Region: CorC_HlyC; smart01091
316401002721	metal-binding heat shock protein; Provisional; Region: PRK00016
316401002722	PS01306 Uncharacterized protein family UPF0054 signature.
316401002723	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
316401002724	PhoH-like protein; Region: PhoH; pfam02562
316401002725	PS00017 ATP/GTP-binding site motif A (P-loop).
316401002726	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
316401002727	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
316401002728	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316401002729	FeS/SAM binding site; other site
316401002730	TRAM domain; Region: TRAM; pfam01938
316401002731	PS01278 Uncharacterized protein family UPF0004 signature.
316401002732	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020
316401002733	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
316401002734	PS01304 ubiH/COQ6 monooxygenase family signature.
316401002735	asparagine synthetase B; Provisional; Region: asnB; PRK09431
316401002736	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
316401002737	active site
316401002738	dimer interface [polypeptide binding]; other site
316401002739	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
316401002740	Ligand Binding Site [chemical binding]; other site
316401002741	Molecular Tunnel; other site
316401002742	PS00443 Glutamine amidotransferases class-II active site.
316401002743	UMP phosphatase; Provisional; Region: PRK10444
316401002744	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
316401002745	active site
316401002746	motif I; other site
316401002747	motif II; other site
316401002748	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
316401002749	MarR family; Region: MarR; pfam01047
316401002750	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
316401002751	ROK family; Region: ROK; pfam00480
316401002752	PS01125 ROK family signature.
316401002753	N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221
316401002754	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
316401002755	active site
316401002756	dimer interface [polypeptide binding]; other site
316401002757	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
316401002758	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
316401002759	active site
316401002760	trimer interface [polypeptide binding]; other site
316401002761	allosteric site; other site
316401002762	active site lid [active]
316401002763	hexamer (dimer of trimers) interface [polypeptide binding]; other site
316401002764	PS01161 Glucosamine/galactosamine-6-phosphate isomerases signature.
316401002765	PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255
316401002766	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
316401002767	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
316401002768	active site turn [active]
316401002769	phosphorylation site [posttranslational modification]
316401002770	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
316401002771	HPr interaction site; other site
316401002772	glycerol kinase (GK) interaction site [polypeptide binding]; other site
316401002773	active site
316401002774	phosphorylation site [posttranslational modification]
316401002775	10 probable transmembrane helices predicted for ETEC0696 by TMHMM2.0 at aa 39-61, 68-90, 94-111, 132-151, 166-185, 192-214, 229-251, 258-280, 295-317 and 337-359
316401002776	PS01035 PTS EIIB domains cysteine phosphorylation site signature.
316401002777	PS00371 PTS EIIA domains phosphorylation site signature 1.
316401002778	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
316401002779	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
316401002780	active site
316401002781	HIGH motif; other site
316401002782	nucleotide binding site [chemical binding]; other site
316401002783	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
316401002784	KMSKS motif; other site
316401002785	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
316401002786	PS00178 Aminoacyl-transfer RNA synthetases class-I signature.
316401002787	outer membrane porin, OprD family; Region: OprD; pfam03573
316401002788	Signal peptide predicted for ETEC0698 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.963 between residues 32 and 33
316401002789	YbfN-like lipoprotein; Region: YbfN; pfam13982
316401002790	Signal peptide predicted for ETEC0699 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.851 between residues 18 and 19
316401002791	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401002792	ferric uptake regulator; Provisional; Region: fur; PRK09462
316401002793	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
316401002794	metal binding site 2 [ion binding]; metal-binding site
316401002795	putative DNA binding helix; other site
316401002796	metal binding site 1 [ion binding]; metal-binding site
316401002797	dimer interface [polypeptide binding]; other site
316401002798	structural Zn2+ binding site [ion binding]; other site
316401002799	flavodoxin FldA; Validated; Region: PRK09267
316401002800	PS00201 Flavodoxin signature.
316401002801	LexA regulated protein; Provisional; Region: PRK11675
316401002802	acyl-CoA esterase; Provisional; Region: PRK10673
316401002803	PGAP1-like protein; Region: PGAP1; pfam07819
316401002804	replication initiation regulator SeqA; Provisional; Region: PRK11187
316401002805	phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132
316401002806	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
316401002807	active site
316401002808	substrate binding site [chemical binding]; other site
316401002809	metal binding site [ion binding]; metal-binding site
316401002810	PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature.
316401002811	Signal peptide predicted for ETEC0706 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.955 between residues 24 and 25
316401002812	1 probable transmembrane helix predicted for ETEC0706 by TMHMM2.0 at aa 7-24
316401002813	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401002814	Protein of unknown function DUF2625; Region: DUF2625; pfam10946
316401002815	putrescine transporter; Provisional; Region: potE; PRK10655
316401002816	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
316401002817	12 probable transmembrane helices predicted for ETEC0708 by TMHMM2.0 at aa 9-31, 37-59, 89-111, 121-143, 150-172, 187-206, 227-249, 269-291, 323-342, 352-374, 387-405 and 410-429
316401002818	PS00017 ATP/GTP-binding site motif A (P-loop).
316401002819	ornithine decarboxylase; Provisional; Region: PRK13578
316401002820	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
316401002821	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
316401002822	homodimer interface [polypeptide binding]; other site
316401002823	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316401002824	catalytic residue [active]
316401002825	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
316401002826	PS00703 Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site.
316401002827	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
316401002828	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316401002829	active site
316401002830	phosphorylation site [posttranslational modification]
316401002831	intermolecular recognition site; other site
316401002832	dimerization interface [polypeptide binding]; other site
316401002833	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
316401002834	DNA binding site [nucleotide binding]
316401002835	sensor protein KdpD; Provisional; Region: PRK10490
316401002836	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
316401002837	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
316401002838	Ligand Binding Site [chemical binding]; other site
316401002839	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
316401002840	GAF domain; Region: GAF_3; pfam13492
316401002841	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316401002842	dimer interface [polypeptide binding]; other site
316401002843	phosphorylation site [posttranslational modification]
316401002844	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316401002845	ATP binding site [chemical binding]; other site
316401002846	Mg2+ binding site [ion binding]; other site
316401002847	G-X-G motif; other site
316401002848	4 probable transmembrane helices predicted for ETEC0711 by TMHMM2.0 at aa 399-421, 425-444, 449-471 and 476-498
316401002849	PS00017 ATP/GTP-binding site motif A (P-loop).
316401002850	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
316401002851	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
316401002852	PS00294 Prenyl group binding site (CAAX box).
316401002853	7 probable transmembrane helices predicted for ETEC0712 by TMHMM2.0 at aa 36-58, 63-85, 220-242, 252-274, 578-600, 615-634 and 654-676
316401002854	PS00154 E1-E2 ATPases phosphorylation site.
316401002855	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
316401002856	12 probable transmembrane helices predicted for ETEC0713 by TMHMM2.0 at aa 5-24, 62-84, 130-152, 173-195, 253-275, 282-304, 327-349, 354-376, 380-399, 416-438, 483-505 and 526-548
316401002857	Signal peptide predicted for ETEC0713 by SignalP 2.0 HMM (Signal peptide probability 0.948) with cleavage site probability 0.913 between residues 20 and 21
316401002858	PAAR motif; Region: PAAR_motif; cl15808
316401002859	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
316401002860	RHS Repeat; Region: RHS_repeat; pfam05593
316401002861	RHS Repeat; Region: RHS_repeat; pfam05593
316401002862	RHS Repeat; Region: RHS_repeat; pfam05593
316401002863	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
316401002864	RHS Repeat; Region: RHS_repeat; pfam05593
316401002865	RHS Repeat; Region: RHS_repeat; pfam05593
316401002866	RHS protein; Region: RHS; pfam03527
316401002867	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
316401002868	Signal peptide predicted for ETEC0715 by SignalP 2.0 HMM (Signal peptide probability 0.985) with cleavage site probability 0.945 between residues 19 and 20
316401002869	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
316401002870	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
316401002871	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
316401002872	Transposase [DNA replication, recombination, and repair]; Region: COG5433
316401002873	Transposase [DNA replication, recombination, and repair]; Region: COG5433
316401002874	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
316401002875	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
316401002876	Transposase [DNA replication, recombination, and repair]; Region: COG5433
316401002877	hypothetical protein; Provisional; Region: PRK10167
316401002878	Uncharacterized conserved protein [Function unknown]; Region: COG3272
316401002879	deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674
316401002880	DNA photolyase; Region: DNA_photolyase; pfam00875
316401002881	PS00230 Neuraxin and MAP1B proteins repeated region signature.
316401002882	PS00394 DNA photolyases class 1 signature 1.
316401002883	PS00691 DNA photolyases class 1 signature 2.
316401002884	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
316401002885	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401002886	putative substrate translocation pore; other site
316401002887	POT family; Region: PTR2; pfam00854
316401002888	14 probable transmembrane helices predicted for ETEC0721 by TMHMM2.0 at aa 13-35, 50-67, 72-94, 104-126, 139-161, 166-188, 209-231, 235-254, 267-284, 310-332, 344-366, 376-398, 410-432 and 462-479
316401002889	PS01023 PTR2 family proton/oligopeptide symporters signature 2.
316401002890	PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature.
316401002891	PS01022 PTR2 family proton/oligopeptide symporters signature 1.
316401002892	Uncharacterized conserved protein [Function unknown]; Region: COG0327
316401002893	metal-binding protein; Provisional; Region: PRK10799
316401002894	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
316401002895	sensor histidine kinase inhibitor, KipI family; Region: TIGR00370
316401002896	biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724
316401002897	Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800
316401002898	putative active site [active]
316401002899	endonuclease VIII; Provisional; Region: PRK10445
316401002900	N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965
316401002901	DNA binding site [nucleotide binding]
316401002902	catalytic residue [active]
316401002903	putative catalytic residues [active]
316401002904	H2TH interface [polypeptide binding]; other site
316401002905	intercalation triad [nucleotide binding]; other site
316401002906	substrate specificity determining residue; other site
316401002907	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
316401002908	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
316401002909	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
316401002910	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
316401002911	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
316401002912	7 probable transmembrane helices predicted for ETEC0727 by TMHMM2.0 at aa 21-38, 43-62, 69-91, 96-118, 159-178, 193-215 and 274-293
316401002913	Fimbrial protein; Region: Fimbrial; pfam00419
316401002914	Signal peptide predicted for ETEC0728 by SignalP 2.0 HMM (Signal peptide probability 0.867) with cleavage site probability 0.684 between residues 23 and 24
316401002915	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
316401002916	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
316401002917	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
316401002918	PS00635 Gram-negative pili assembly chaperone signature.
316401002919	Signal peptide predicted for ETEC0729 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 20 and 21
316401002920	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401002921	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
316401002922	PapC N-terminal domain; Region: PapC_N; pfam13954
316401002923	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
316401002924	PapC C-terminal domain; Region: PapC_C; pfam13953
316401002925	PS01151 Fimbrial biogenesis outer membrane usher protein signature.
316401002926	Signal peptide predicted for ETEC0730 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 21 and 22
316401002927	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
316401002928	Signal peptide predicted for ETEC0730A by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 23 and 24
316401002929	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
316401002930	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
316401002931	dimer interface [polypeptide binding]; other site
316401002932	active site
316401002933	citrylCoA binding site [chemical binding]; other site
316401002934	NADH binding [chemical binding]; other site
316401002935	cationic pore residues; other site
316401002936	oxalacetate/citrate binding site [chemical binding]; other site
316401002937	coenzyme A binding site [chemical binding]; other site
316401002938	catalytic triad [active]
316401002939	PS00480 Citrate synthase signature.
316401002940	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
316401002941	Iron-sulfur protein interface; other site
316401002942	proximal quinone binding site [chemical binding]; other site
316401002943	SdhD (CybS) interface [polypeptide binding]; other site
316401002944	proximal heme binding site [chemical binding]; other site
316401002945	PS01000 Succinate dehydrogenase cytochrome b subunit signature 1.
316401002946	3 probable transmembrane helices predicted for ETEC0732 by TMHMM2.0 at aa 27-49, 64-86 and 112-128
316401002947	PS01001 Succinate dehydrogenase cytochrome b subunit signature 2.
316401002948	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
316401002949	SdhC subunit interface [polypeptide binding]; other site
316401002950	proximal heme binding site [chemical binding]; other site
316401002951	cardiolipin binding site; other site
316401002952	Iron-sulfur protein interface; other site
316401002953	proximal quinone binding site [chemical binding]; other site
316401002954	3 probable transmembrane helices predicted for ETEC0733 by TMHMM2.0 at aa 16-38, 48-70 and 91-113
316401002955	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958
316401002956	L-aspartate oxidase; Provisional; Region: PRK06175
316401002957	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
316401002958	PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site.
316401002959	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
316401002960	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
316401002961	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401002962	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
316401002963	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
316401002964	TPP-binding site [chemical binding]; other site
316401002965	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
316401002966	dimer interface [polypeptide binding]; other site
316401002967	PYR/PP interface [polypeptide binding]; other site
316401002968	TPP binding site [chemical binding]; other site
316401002969	PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide.
316401002970	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
316401002971	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
316401002972	E3 interaction surface; other site
316401002973	lipoyl attachment site [posttranslational modification]; other site
316401002974	e3 binding domain; Region: E3_binding; pfam02817
316401002975	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
316401002976	PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site.
316401002977	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
316401002978	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
316401002979	CoA-ligase; Region: Ligase_CoA; pfam00549
316401002980	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401002981	PS01217 ATP-citrate lyase / succinyl-CoA ligases family signature 3.
316401002982	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
316401002983	CoA binding domain; Region: CoA_binding; smart00881
316401002984	CoA-ligase; Region: Ligase_CoA; pfam00549
316401002985	PS01216 ATP-citrate lyase / succinyl-CoA ligases family signature 1.
316401002986	PS00399 ATP-citrate lyase / succinyl-CoA ligases family active site.
316401002987	DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764
316401002988	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
316401002989	DNA-binding site [nucleotide binding]; DNA binding site
316401002990	UTRA domain; Region: UTRA; pfam07702
316401002991	PS00043 Bacterial regulatory proteins, gntR family signature.
316401002992	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
316401002993	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
316401002994	active site
316401002995	phosphorylation site [posttranslational modification]
316401002996	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
316401002997	active site
316401002998	P-loop; other site
316401002999	phosphorylation site [posttranslational modification]
316401003000	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
316401003001	8 probable transmembrane helices predicted for ETEC0741 by TMHMM2.0 at aa 316-338, 357-379, 389-411, 431-453, 463-485, 498-520, 574-596 and 603-625
316401003002	alpha-mannosidase; Provisional; Region: PRK09819
316401003003	N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815
316401003004	active site
316401003005	metal binding site [ion binding]; metal-binding site
316401003006	catalytic site [active]
316401003007	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
316401003008	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
316401003009	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
316401003010	9 probable transmembrane helices predicted for ETEC0743 by TMHMM2.0 at aa 20-42, 54-76, 96-118, 130-152, 184-206, 219-238, 387-409, 421-443 and 471-493
316401003011	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003
316401003012	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
316401003013	8 probable transmembrane helices predicted for ETEC0744 by TMHMM2.0 at aa 7-24, 77-99, 123-145, 160-182, 203-225, 262-281, 293-315 and 335-357
316401003014	Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039
316401003015	Signal peptide predicted for ETEC0745 by SignalP 2.0 HMM (Signal peptide probability 0.981) with cleavage site probability 0.641 between residues 23 and 24
316401003016	1 probable transmembrane helix predicted for ETEC0745 by TMHMM2.0 at aa 2-24
316401003017	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401003018	hypothetical protein; Provisional; Region: PRK10588
316401003019	Signal peptide predicted for ETEC0746 by SignalP 2.0 HMM (Signal peptide probability 0.673) with cleavage site probability 0.634 between residues 40 and 41
316401003020	3 probable transmembrane helices predicted for ETEC0746 by TMHMM2.0 at aa 19-36, 46-68 and 73-95
316401003021	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
316401003022	active site
316401003023	PS01328 4-hydroxybenzoyl-CoA thioesterase family active site.
316401003024	colicin uptake protein TolQ; Provisional; Region: PRK10801
316401003025	3 probable transmembrane helices predicted for ETEC0748 by TMHMM2.0 at aa 15-37, 133-155 and 170-192
316401003026	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
316401003027	colicin uptake protein TolR; Provisional; Region: PRK11024
316401003028	1 probable transmembrane helix predicted for ETEC0749 by TMHMM2.0 at aa 17-39
316401003029	cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510
316401003030	cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510
316401003031	TolA C-terminal; Region: TolA; pfam06519
316401003032	1 probable transmembrane helix predicted for ETEC0750 by TMHMM2.0 at aa 13-32
316401003033	PS00017 ATP/GTP-binding site motif A (P-loop).
316401003034	translocation protein TolB; Provisional; Region: tolB; PRK03629
316401003035	TolB amino-terminal domain; Region: TolB_N; pfam04052
316401003036	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
316401003037	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
316401003038	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
316401003039	Signal peptide predicted for ETEC0751 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.995 between residues 21 and 22
316401003040	peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802
316401003041	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
316401003042	ligand binding site [chemical binding]; other site
316401003043	Signal peptide predicted for ETEC0752 by SignalP 2.0 HMM (Signal peptide probability 0.961) with cleavage site probability 0.451 between residues 26 and 27
316401003044	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401003045	PS01068 OmpA-like domain.
316401003046	tol-pal system protein YbgF; Provisional; Region: PRK10803
316401003047	Tetratricopeptide repeat; Region: TPR_6; pfam13174
316401003048	Tetratricopeptide repeat; Region: TPR_6; pfam13174
316401003049	Signal peptide predicted for ETEC0753 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.991 between residues 26 and 27
316401003050	quinolinate synthetase; Provisional; Region: PRK09375
316401003051	nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397
316401003052	6 probable transmembrane helices predicted for ETEC0755 by TMHMM2.0 at aa 20-42, 49-68, 72-89, 110-132, 158-177 and 184-206
316401003053	zinc transporter ZitB; Provisional; Region: PRK03557
316401003054	PS00511 Corticotropin-releasing factor family signature.
316401003055	5 probable transmembrane helices predicted for ETEC0756 by TMHMM2.0 at aa 21-43, 53-71, 84-106, 121-143 and 164-183
316401003056	YbgS-like protein; Region: YbgS; pfam13985
316401003057	PS00141 Eukaryotic and viral aspartyl proteases active site.
316401003058	Signal peptide predicted for ETEC0757 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 24 and 25
316401003059	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
316401003060	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
316401003061	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
316401003062	catalytic core [active]
316401003063	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
316401003064	PS00175 Phosphoglycerate mutase family phosphohistidine signature.
316401003065	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
316401003066	active site
316401003067	catalytic residues [active]
316401003068	PS00545 Aldose 1-epimerase putative active site.
316401003069	galactokinase; Provisional; Region: PRK05101
316401003070	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
316401003071	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
316401003072	PS00627 GHMP kinases putative ATP-binding domain.
316401003073	PS00106 Galactokinase signature.
316401003074	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
316401003075	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
316401003076	dimer interface [polypeptide binding]; other site
316401003077	active site
316401003078	PS00117 Galactose-1-phosphate uridyl transferase family 1 active site signature.
316401003079	UDP-galactose-4-epimerase; Provisional; Region: PRK10675
316401003080	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
316401003081	NAD binding site [chemical binding]; other site
316401003082	homodimer interface [polypeptide binding]; other site
316401003083	active site
316401003084	substrate binding site [chemical binding]; other site
316401003085	putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938
316401003086	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
316401003087	Walker A/P-loop; other site
316401003088	ATP binding site [chemical binding]; other site
316401003089	Q-loop/lid; other site
316401003090	ABC transporter signature motif; other site
316401003091	Walker B; other site
316401003092	D-loop; other site
316401003093	H-loop/switch region; other site
316401003094	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316401003095	Walker A/P-loop; other site
316401003096	ATP binding site [chemical binding]; other site
316401003097	Q-loop/lid; other site
316401003098	ABC transporter signature motif; other site
316401003099	Walker B; other site
316401003100	D-loop; other site
316401003101	H-loop/switch region; other site
316401003102	PS00017 ATP/GTP-binding site motif A (P-loop).
316401003103	PS00017 ATP/GTP-binding site motif A (P-loop).
316401003104	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
316401003105	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
316401003106	molybdenum-pterin binding domain; Region: Mop; TIGR00638
316401003107	TOBE domain; Region: TOBE; pfam03459
316401003108	Protein of unknown function (DUF2592); Region: DUF2592; pfam10766
316401003109	1 probable transmembrane helix predicted for ETEC0766 by TMHMM2.0 at aa 7-29
316401003110	molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677
316401003111	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
316401003112	substrate binding pocket [chemical binding]; other site
316401003113	membrane-bound complex binding site; other site
316401003114	hinge residues; other site
316401003115	PS00430 TonB-dependent receptor proteins signature 1.
316401003116	Signal peptide predicted for ETEC0767 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 24 and 25
316401003117	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
316401003118	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401003119	putative PBP binding loops; other site
316401003120	ABC-ATPase subunit interface; other site
316401003121	5 probable transmembrane helices predicted for ETEC0768 by TMHMM2.0 at aa 15-37, 49-71, 86-108, 136-158 and 197-219
316401003122	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
316401003123	molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144
316401003124	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316401003125	Walker A/P-loop; other site
316401003126	ATP binding site [chemical binding]; other site
316401003127	Q-loop/lid; other site
316401003128	ABC transporter signature motif; other site
316401003129	Walker B; other site
316401003130	D-loop; other site
316401003131	H-loop/switch region; other site
316401003132	molybdenum-pterin binding domain; Region: Mop; TIGR00638
316401003133	PS00017 ATP/GTP-binding site motif A (P-loop).
316401003134	PS00211 ABC transporters family signature.
316401003135	pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530
316401003136	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
316401003137	motif II; other site
316401003138	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
316401003139	PS01229 Hypothetical cof family signature 2.
316401003140	PS01228 Hypothetical cof family signature 1.
316401003141	6-phosphogluconolactonase; Provisional; Region: PRK11028
316401003142	This CDS has been interrupted by an insertion sequence transposase
316401003143	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
316401003144	PrpF protein; Region: PrpF; pfam04303
316401003145	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
316401003146	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
316401003147	transmembrane helices; other site
316401003148	Signal peptide predicted for ETEC0775 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.598 between residues 28 and 29
316401003149	15 probable transmembrane helices predicted for ETEC0775 by TMHMM2.0 at aa 5-27, 31-48, 55-72, 87-105, 112-134, 149-166, 178-200, 220-242, 274-293, 297-314, 327-349, 364-381, 386-408, 418-440 and 445-464
316401003150	2 probable transmembrane helices predicted for ETEC0776 by TMHMM2.0 at aa 7-29 and 39-61
316401003151	Signal peptide predicted for ETEC0776 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.957 between residues 27 and 28
316401003152	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
316401003153	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
316401003154	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
316401003155	PS00017 ATP/GTP-binding site motif A (P-loop).
316401003156	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
316401003157	putative hydratase; Provisional; Region: PRK11413
316401003158	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
316401003159	substrate binding site [chemical binding]; other site
316401003160	ligand binding site [chemical binding]; other site
316401003161	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
316401003162	substrate binding site [chemical binding]; other site
316401003163	acyl-CoA thioesterase; Provisional; Region: PRK10531
316401003164	putative pectinesterase; Region: PLN02432; cl01911
316401003165	PS00503 Pectinesterase signature 2.
316401003166	PS00800 Pectinesterase signature 1.
316401003167	Signal peptide predicted for ETEC0779 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.843 between residues 23 and 24
316401003168	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401003169	Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003
316401003170	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
316401003171	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
316401003172	Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome.  They belong to the superfamily...; Region: INT_Lambda_C; cd00800
316401003173	dimer interface [polypeptide binding]; other site
316401003174	active site
316401003175	Int/Topo IB signature motif; other site
316401003176	3 probable transmembrane helices predicted for ETEC0782 by TMHMM2.0 at aa 30-52, 67-84 and 104-126
316401003177	Protein of unknown function (DUF1382); Region: DUF1382; pfam07131
316401003178	YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588
316401003179	phage recombination protein Bet; Region: bet_lambda; TIGR01913
316401003180	Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064
316401003181	Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301
316401003182	Protein of unknown function (DUF2528); Region: DUF2528; pfam10800
316401003183	2 probable transmembrane helices predicted for ETEC0790 by TMHMM2.0 at aa 41-63 and 102-124
316401003184	Antirestriction protein Ral; Region: Ral; pfam11058
316401003185	Superinfection exclusion protein B; Region: SieB; pfam14163
316401003186	2 probable transmembrane helices predicted for ETEC0792 by TMHMM2.0 at aa 13-31 and 46-68
316401003187	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
316401003188	non-specific DNA binding site [nucleotide binding]; other site
316401003189	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
316401003190	salt bridge; other site
316401003191	sequence-specific DNA binding site [nucleotide binding]; other site
316401003192	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
316401003193	Catalytic site [active]
316401003194	DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744
316401003195	Bacteriophage CII protein; Region: Phage_CII; pfam05269
316401003196	Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492
316401003197	Replication protein P; Region: Phage_lambda_P; pfam06992
316401003198	NinB protein; Region: NinB; pfam05772
316401003199	phage N-6-adenine-methyltransferase; Region: phage_N6A_met; TIGR01712
316401003200	PS00092 N-6 Adenine-specific DNA methylases signature.
316401003201	hypothetical protein; Region: PHA01519
316401003202	endodeoxyribonuclease RUS; Reviewed; Region: PRK09786
316401003203	Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530
316401003204	PS00228 Tubulin-beta mRNA autoregulation signal.
316401003205	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
316401003206	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
316401003207	trimer interface [polypeptide binding]; other site
316401003208	eyelet of channel; other site
316401003209	PS00576 General diffusion Gram-negative porins signature.
316401003210	Signal peptide predicted for ETEC0806 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 23 and 24
316401003211	Lysis protein S; Region: Lysis_S; pfam04971
316401003212	2 probable transmembrane helices predicted for ETEC0807 by TMHMM2.0 at aa 7-26 and 36-58
316401003213	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
316401003214	catalytic residues [active]
316401003215	Signal peptide predicted for ETEC0808 by SignalP 2.0 HMM (Signal peptide probability 0.927) with cleavage site probability 0.349 between residues 21 and 22
316401003216	Lipoprotein Rz1 precursor; Region: Rz1; pfam06085
316401003217	Signal peptide predicted for ETEC0809 by SignalP 2.0 HMM (Signal peptide probability 0.978) with cleavage site probability 0.516 between residues 19 and 20
316401003218	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401003219	Cation transport protein; Region: TrkH; cl17365
316401003220	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
316401003221	11 probable transmembrane helices predicted for ETEC0810 by TMHMM2.0 at aa 12-34, 39-58, 71-93, 139-161, 188-207, 241-263, 276-298, 334-356, 398-420, 430-452 and 459-481
316401003222	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
316401003223	ParB-like nuclease domain; Region: ParBc; pfam02195
316401003224	Terminase small subunit; Region: Terminase_2; cl01513
316401003225	Phage terminase large subunit; Region: Terminase_3; cl12054
316401003226	Terminase-like family; Region: Terminase_6; pfam03237
316401003227	PS00017 ATP/GTP-binding site motif A (P-loop).
316401003228	Domain of unknown function (DUF4055); Region: DUF4055; pfam13264
316401003229	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
316401003230	P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651
316401003231	Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554
316401003232	PS00215 Mitochondrial energy transfer proteins signature.
316401003233	Phage-related minor tail protein [Function unknown]; Region: COG5281
316401003234	Prophage tail length tape measure protein; Region: TMP_2; pfam06791
316401003235	Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718
316401003236	Phage minor tail protein; Region: Phage_min_tail; pfam05939
316401003237	Phage-related protein [Function unknown]; Region: gp18; COG4672
316401003238	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073
316401003239	MPN+ (JAMM) motif; other site
316401003240	Zinc-binding site [ion binding]; other site
316401003241	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
316401003242	NlpC/P60 family; Region: NLPC_P60; cl17555
316401003243	Phage-related protein, tail component [Function unknown]; Region: COG4723
316401003244	2 probable transmembrane helices predicted for ETEC0832 by TMHMM2.0 at aa 89-111 and 116-138
316401003245	Phage-related protein, tail component [Function unknown]; Region: COG4733
316401003246	Putative phage tail protein; Region: Phage-tail_3; pfam13550
316401003247	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
316401003248	Interdomain contacts; other site
316401003249	Cytokine receptor motif; other site
316401003250	Domain of unknown function (DUF1983); Region: DUF1983; pfam09327
316401003251	Fibronectin type III protein; Region: DUF3672; pfam12421
316401003252	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
316401003253	Signal peptide predicted for ETEC0834 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.950 between residues 24 and 25
316401003254	PS00694 Enterobacterial virulence outer membrane protein signature 1.
316401003255	PS00695 Enterobacterial virulence outer membrane protein signature 2.
316401003256	Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400
316401003257	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
316401003258	Phage Tail Collar Domain; Region: Collar; pfam07484
316401003259	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
316401003260	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
316401003261	substrate binding site [chemical binding]; other site
316401003262	adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986
316401003263	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
316401003264	inhibitor-cofactor binding pocket; inhibition site
316401003265	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316401003266	catalytic residue [active]
316401003267	PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site.
316401003268	biotin synthase; Provisional; Region: PRK15108
316401003269	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316401003270	FeS/SAM binding site; other site
316401003271	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
316401003272	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
316401003273	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
316401003274	substrate-cofactor binding pocket; other site
316401003275	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316401003276	catalytic residue [active]
316401003277	PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site.
316401003278	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
316401003279	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316401003280	S-adenosylmethionine binding site [chemical binding]; other site
316401003281	AAA domain; Region: AAA_26; pfam13500
316401003282	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
316401003283	Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109
316401003284	ADP binding site [chemical binding]; other site
316401003285	excinuclease ABC subunit B; Provisional; Region: PRK05298
316401003286	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
316401003287	ATP binding site [chemical binding]; other site
316401003288	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
316401003289	nucleotide binding region [chemical binding]; other site
316401003290	ATP-binding site [chemical binding]; other site
316401003291	Ultra-violet resistance protein B; Region: UvrB; pfam12344
316401003292	UvrB/uvrC motif; Region: UVR; pfam02151
316401003293	PS00017 ATP/GTP-binding site motif A (P-loop).
316401003294	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
316401003295	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
316401003296	putative substrate binding pocket [chemical binding]; other site
316401003297	dimer interface [polypeptide binding]; other site
316401003298	phosphate binding site [ion binding]; other site
316401003299	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
316401003300	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316401003301	FeS/SAM binding site; other site
316401003302	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
316401003303	PS01305 moaA / nifB / pqqE family signature.
316401003304	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
316401003305	MPT binding site; other site
316401003306	trimer interface [polypeptide binding]; other site
316401003307	PS01078 Molybdenum cofactor biosynthesis proteins signature 1.
316401003308	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
316401003309	trimer interface [polypeptide binding]; other site
316401003310	dimer interface [polypeptide binding]; other site
316401003311	putative active site [active]
316401003312	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
316401003313	MoaE interaction surface [polypeptide binding]; other site
316401003314	MoeB interaction surface [polypeptide binding]; other site
316401003315	thiocarboxylated glycine; other site
316401003316	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
316401003317	MoaE homodimer interface [polypeptide binding]; other site
316401003318	MoaD interaction [polypeptide binding]; other site
316401003319	active site residues [active]
316401003320	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
316401003321	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
316401003322	7 probable transmembrane helices predicted for ETEC0851 by TMHMM2.0 at aa 21-43, 58-77, 84-106, 110-132, 139-161, 165-184 and 209-231
316401003323	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
316401003324	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
316401003325	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
316401003326	PS00017 ATP/GTP-binding site motif A (P-loop).
316401003327	IS1 transposase; Region: DDE_Tnp_IS1; pfam03400
316401003328	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
316401003329	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
316401003330	7 probable transmembrane helices predicted for ETEC0854 by TMHMM2.0 at aa 20-39, 54-71, 78-100, 105-127, 134-156, 160-179 and 207-229
316401003331	Predicted integral membrane protein [Function unknown]; Region: COG0392
316401003332	8 probable transmembrane helices predicted for ETEC0855 by TMHMM2.0 at aa 13-30, 50-72, 85-107, 131-153, 166-185, 205-227, 234-256 and 281-303
316401003333	Signal peptide predicted for ETEC0855 by SignalP 2.0 HMM (Signal peptide probability 0.990) with cleavage site probability 0.929 between residues 31 and 32
316401003334	cardiolipin synthase 2; Provisional; Region: PRK11263
316401003335	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
316401003336	putative active site [active]
316401003337	catalytic site [active]
316401003338	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
316401003339	putative active site [active]
316401003340	catalytic site [active]
316401003341	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
316401003342	putative catalytic site [active]
316401003343	putative metal binding site [ion binding]; other site
316401003344	putative phosphate binding site [ion binding]; other site
316401003345	Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076
316401003346	4 probable transmembrane helices predicted for ETEC0858 by TMHMM2.0 at aa 13-32, 36-58, 79-96 and 100-119
316401003347	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
316401003348	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
316401003349	6 probable transmembrane helices predicted for ETEC0859 by TMHMM2.0 at aa 24-46, 173-195, 223-245, 255-277, 284-303 and 341-363
316401003350	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
316401003351	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
316401003352	6 probable transmembrane helices predicted for ETEC0860 by TMHMM2.0 at aa 27-49, 182-204, 231-253, 263-285, 292-314 and 348-370
316401003353	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
316401003354	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
316401003355	Walker A/P-loop; other site
316401003356	ATP binding site [chemical binding]; other site
316401003357	Q-loop/lid; other site
316401003358	ABC transporter signature motif; other site
316401003359	Walker B; other site
316401003360	D-loop; other site
316401003361	H-loop/switch region; other site
316401003362	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
316401003363	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
316401003364	Walker A/P-loop; other site
316401003365	ATP binding site [chemical binding]; other site
316401003366	Q-loop/lid; other site
316401003367	ABC transporter signature motif; other site
316401003368	Walker B; other site
316401003369	D-loop; other site
316401003370	H-loop/switch region; other site
316401003371	PS00017 ATP/GTP-binding site motif A (P-loop).
316401003372	PS00211 ABC transporters family signature.
316401003373	PS00017 ATP/GTP-binding site motif A (P-loop).
316401003374	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
316401003375	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
316401003376	HlyD family secretion protein; Region: HlyD_3; pfam13437
316401003377	1 probable transmembrane helix predicted for ETEC0862 by TMHMM2.0 at aa 7-26
316401003378	Signal peptide predicted for ETEC0862 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.684 between residues 20 and 21
316401003379	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552
316401003380	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
316401003381	PS01081 Bacterial regulatory proteins, tetR family signature.
316401003382	helicase 45; Provisional; Region: PTZ00424
316401003383	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
316401003384	ATP binding site [chemical binding]; other site
316401003385	Mg++ binding site [ion binding]; other site
316401003386	motif III; other site
316401003387	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
316401003388	nucleotide binding region [chemical binding]; other site
316401003389	ATP-binding site [chemical binding]; other site
316401003390	PS00017 ATP/GTP-binding site motif A (P-loop).
316401003391	PS00039 DEAD-box subfamily ATP-dependent helicases signature.
316401003392	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3236
316401003393	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
316401003394	DEAD_2; Region: DEAD_2; pfam06733
316401003395	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
316401003396	PS00017 ATP/GTP-binding site motif A (P-loop).
316401003397	glycosyl transferase family protein; Provisional; Region: PRK08136
316401003398	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
316401003399	putative dehydrogenase; Provisional; Region: PRK10098
316401003400	PS00017 ATP/GTP-binding site motif A (P-loop).
316401003401	hypothetical protein; Provisional; Region: PRK10259
316401003402	1 probable transmembrane helix predicted for ETEC0869 by TMHMM2.0 at aa 7-29
316401003403	Signal peptide predicted for ETEC0869 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 22 and 23
316401003404	hypothetical protein; Provisional; Region: PRK11019
316401003405	PS01102 Prokaryotic dksA/traR C4-type zinc finger.
316401003406	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
316401003407	catecholate siderophore receptor Fiu; Provisional; Region: PRK09840
316401003408	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
316401003409	N-terminal plug; other site
316401003410	ligand-binding site [chemical binding]; other site
316401003411	PS00430 TonB-dependent receptor proteins signature 1.
316401003412	1 probable transmembrane helix predicted for ETEC0872 by TMHMM2.0 at aa 12-34
316401003413	Signal peptide predicted for ETEC0872 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.949 between residues 33 and 34
316401003414	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
316401003415	1 probable transmembrane helix predicted for ETEC0873 by TMHMM2.0 at aa 5-24
316401003416	Signal peptide predicted for ETEC0873 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 22 and 23
316401003417	23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727
316401003418	Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971
316401003419	putative mechanosensitive channel protein; Provisional; Region: PRK11465
316401003420	Mechanosensitive ion channel; Region: MS_channel; pfam00924
316401003421	11 probable transmembrane helices predicted for ETEC0875 by TMHMM2.0 at aa 5-27, 138-160, 181-203, 218-240, 268-287, 292-314, 335-357, 372-394, 432-451, 466-488 and 509-531
316401003422	Signal peptide predicted for ETEC0875 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 18 and 19
316401003423	glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493
316401003424	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
316401003425	Walker A/P-loop; other site
316401003426	ATP binding site [chemical binding]; other site
316401003427	Q-loop/lid; other site
316401003428	ABC transporter signature motif; other site
316401003429	Walker B; other site
316401003430	D-loop; other site
316401003431	H-loop/switch region; other site
316401003432	PS00211 ABC transporters family signature.
316401003433	PS00017 ATP/GTP-binding site motif A (P-loop).
316401003434	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
316401003435	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401003436	dimer interface [polypeptide binding]; other site
316401003437	conserved gate region; other site
316401003438	putative PBP binding loops; other site
316401003439	ABC-ATPase subunit interface; other site
316401003440	3 probable transmembrane helices predicted for ETEC0877 by TMHMM2.0 at aa 20-42, 54-76 and 187-209
316401003441	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
316401003442	glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495
316401003443	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
316401003444	substrate binding pocket [chemical binding]; other site
316401003445	membrane-bound complex binding site; other site
316401003446	hinge residues; other site
316401003447	PS01039 Bacterial extracellular solute-binding proteins, family 3 signature.
316401003448	Signal peptide predicted for ETEC0878 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 22 and 23
316401003449	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
316401003450	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
316401003451	dimerization interface [polypeptide binding]; other site
316401003452	DPS ferroxidase diiron center [ion binding]; other site
316401003453	ion pore; other site
316401003454	PS00819 Dps protein family signature 2.
316401003455	PS00818 Dps protein family signature 1.
316401003456	threonine and homoserine efflux system; Provisional; Region: PRK10532
316401003457	EamA-like transporter family; Region: EamA; pfam00892
316401003458	10 probable transmembrane helices predicted for ETEC0880 by TMHMM2.0 at aa 9-31, 37-59, 72-89, 93-115, 122-139, 144-166, 179-198, 203-225, 238-257 and 261-283
316401003459	Signal peptide predicted for ETEC0880 by SignalP 2.0 HMM (Signal peptide probability 0.937) with cleavage site probability 0.858 between residues 31 and 32
316401003460	outer membrane protein X; Provisional; Region: ompX; PRK09408
316401003461	Signal peptide predicted for ETEC0881 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.991 between residues 23 and 24
316401003462	1 probable transmembrane helix predicted for ETEC0881 by TMHMM2.0 at aa 7-29
316401003463	PS00694 Enterobacterial virulence outer membrane protein signature 1.
316401003464	PS00695 Enterobacterial virulence outer membrane protein signature 2.
316401003465	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
316401003466	Sulfatase; Region: Sulfatase; pfam00884
316401003467	4 probable transmembrane helices predicted for ETEC0882 by TMHMM2.0 at aa 32-54, 63-85, 105-127 and 144-166
316401003468	manganese transport regulator MntR; Provisional; Region: PRK11050
316401003469	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
316401003470	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
316401003471	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
316401003472	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
316401003473	transmembrane helices; other site
316401003474	9 probable transmembrane helices predicted for ETEC0885 by TMHMM2.0 at aa 13-32, 42-64, 84-106, 159-181, 202-219, 223-242, 249-268, 312-334 and 347-369
316401003475	L,D-transpeptidase; Provisional; Region: PRK10260
316401003476	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
316401003477	1 probable transmembrane helix predicted for ETEC0886 by TMHMM2.0 at aa 7-29
316401003478	Signal peptide predicted for ETEC0886 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.989 between residues 24 and 25
316401003479	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
316401003480	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316401003481	Walker A/P-loop; other site
316401003482	ATP binding site [chemical binding]; other site
316401003483	Q-loop/lid; other site
316401003484	ABC transporter signature motif; other site
316401003485	Walker B; other site
316401003486	D-loop; other site
316401003487	H-loop/switch region; other site
316401003488	ABC transporter; Region: ABC_tran_2; pfam12848
316401003489	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
316401003490	PS00017 ATP/GTP-binding site motif A (P-loop).
316401003491	PS00017 ATP/GTP-binding site motif A (P-loop).
316401003492	Protein of unknown function (DUF1479); Region: DUF1479; pfam07350
316401003493	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
316401003494	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
316401003495	active site
316401003496	motif I; other site
316401003497	motif II; other site
316401003498	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
316401003499	PS01229 Hypothetical cof family signature 2.
316401003500	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
316401003501	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
316401003502	dimer interface [polypeptide binding]; other site
316401003503	active site
316401003504	glycine loop; other site
316401003505	PS00850 Glycine radical signature.
316401003506	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
316401003507	PS01087 Radical activating enzymes signature.
316401003508	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
316401003509	active site
316401003510	intersubunit interactions; other site
316401003511	catalytic residue [active]
316401003512	PS01054 Transaldolase signature 1.
316401003513	PS00958 Transaldolase active site.
316401003514	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
316401003515	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
316401003516	ATP binding site [chemical binding]; other site
316401003517	substrate interface [chemical binding]; other site
316401003518	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680
316401003519	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
316401003520	dimer interface [polypeptide binding]; other site
316401003521	putative functional site; other site
316401003522	putative MPT binding site; other site
316401003523	PS01079 Molybdenum cofactor biosynthesis proteins signature 2.
316401003524	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
316401003525	catalytic nucleophile [active]
316401003526	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
316401003527	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
316401003528	Walker A/P-loop; other site
316401003529	ATP binding site [chemical binding]; other site
316401003530	Q-loop/lid; other site
316401003531	ABC transporter signature motif; other site
316401003532	Walker B; other site
316401003533	D-loop; other site
316401003534	H-loop/switch region; other site
316401003535	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
316401003536	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
316401003537	Walker A/P-loop; other site
316401003538	ATP binding site [chemical binding]; other site
316401003539	Q-loop/lid; other site
316401003540	ABC transporter signature motif; other site
316401003541	Walker B; other site
316401003542	D-loop; other site
316401003543	H-loop/switch region; other site
316401003544	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
316401003545	PS00017 ATP/GTP-binding site motif A (P-loop).
316401003546	PS00211 ABC transporters family signature.
316401003547	PS00017 ATP/GTP-binding site motif A (P-loop).
316401003548	PS00211 ABC transporters family signature.
316401003549	glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413
316401003550	The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499
316401003551	Signal peptide predicted for ETEC0897 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 26 and 27
316401003552	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401003553	PS01040 Bacterial extracellular solute-binding proteins, family 5 signature.
316401003554	glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081
316401003555	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401003556	dimer interface [polypeptide binding]; other site
316401003557	conserved gate region; other site
316401003558	putative PBP binding loops; other site
316401003559	ABC-ATPase subunit interface; other site
316401003560	6 probable transmembrane helices predicted for ETEC0898 by TMHMM2.0 at aa 9-31, 101-123, 135-157, 172-189, 227-249 and 278-300
316401003561	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
316401003562	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
316401003563	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
316401003564	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401003565	dimer interface [polypeptide binding]; other site
316401003566	conserved gate region; other site
316401003567	putative PBP binding loops; other site
316401003568	ABC-ATPase subunit interface; other site
316401003569	6 probable transmembrane helices predicted for ETEC0899 by TMHMM2.0 at aa 40-62, 107-129, 136-158, 163-185, 209-231 and 266-288
316401003570	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
316401003571	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
316401003572	Signal peptide predicted for ETEC0900 by SignalP 2.0 HMM (Signal peptide probability 0.745) with cleavage site probability 0.523 between residues 35 and 36
316401003573	2 probable transmembrane helices predicted for ETEC0900 by TMHMM2.0 at aa 10-32 and 287-309
316401003574	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
316401003575	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316401003576	metal binding site [ion binding]; metal-binding site
316401003577	active site
316401003578	I-site; other site
316401003579	Signal peptide predicted for ETEC0901 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.965 between residues 23 and 24
316401003580	2 probable transmembrane helices predicted for ETEC0901 by TMHMM2.0 at aa 7-29 and 228-250
316401003581	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401003582	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
316401003583	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
316401003584	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
316401003585	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316401003586	FeS/SAM binding site; other site
316401003587	PS01278 Uncharacterized protein family UPF0004 signature.
316401003588	biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302
316401003589	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
316401003590	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
316401003591	Signal peptide predicted for ETEC0904 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.995 between residues 20 and 21
316401003592	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
316401003593	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
316401003594	putative C-terminal domain interface [polypeptide binding]; other site
316401003595	putative GSH binding site (G-site) [chemical binding]; other site
316401003596	putative dimer interface [polypeptide binding]; other site
316401003597	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
316401003598	N-terminal domain interface [polypeptide binding]; other site
316401003599	dimer interface [polypeptide binding]; other site
316401003600	substrate binding pocket (H-site) [chemical binding]; other site
316401003601	D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001
316401003602	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
316401003603	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
316401003604	Signal peptide predicted for ETEC0906 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 27 and 28
316401003605	DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681
316401003606	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
316401003607	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
316401003608	PS00894 Bacterial regulatory proteins, deoR family signature.
316401003609	PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385
316401003610	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
316401003611	active site
316401003612	4 probable transmembrane helices predicted for ETEC0908 by TMHMM2.0 at aa 27-49, 56-78, 121-143 and 150-172
316401003613	multidrug efflux system translocase MdfA; Provisional; Region: PRK15402
316401003614	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401003615	putative substrate translocation pore; other site
316401003616	12 probable transmembrane helices predicted for ETEC0909 by TMHMM2.0 at aa 12-31, 51-73, 86-103, 108-130, 143-165, 169-188, 220-242, 257-279, 286-308, 313-335, 348-367 and 377-399
316401003617	PS00216 Sugar transport proteins signature 1.
316401003618	1 probable transmembrane helix predicted for ETEC0910 by TMHMM2.0 at aa 5-27
316401003619	Signal peptide predicted for ETEC0910 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 22 and 23
316401003620	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
316401003621	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
316401003622	active site
316401003623	motif I; other site
316401003624	motif II; other site
316401003625	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
316401003626	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
316401003627	PS01229 Hypothetical cof family signature 2.
316401003628	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401003629	putative substrate translocation pore; other site
316401003630	Major Facilitator Superfamily; Region: MFS_1; pfam07690
316401003631	12 probable transmembrane helices predicted for ETEC0912 by TMHMM2.0 at aa 12-34, 49-71, 78-100, 104-126, 139-161, 165-187, 208-230, 253-275, 282-301, 305-327, 340-362 and 367-389
316401003632	Signal peptide predicted for ETEC0912 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.955 between residues 29 and 30
316401003633	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
316401003634	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
316401003635	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
316401003636	putative transporter; Provisional; Region: PRK04972
316401003637	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
316401003638	TrkA-C domain; Region: TrkA_C; pfam02080
316401003639	TrkA-C domain; Region: TrkA_C; pfam02080
316401003640	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
316401003641	9 probable transmembrane helices predicted for ETEC0914 by TMHMM2.0 at aa 13-35, 64-86, 93-115, 159-181, 383-402, 406-428, 449-471, 476-498 and 535-557
316401003642	Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045
316401003643	Signal peptide predicted for ETEC0915 by SignalP 2.0 HMM (Signal peptide probability 0.812) with cleavage site probability 0.367 between residues 26 and 27
316401003644	4 probable transmembrane helices predicted for ETEC0915 by TMHMM2.0 at aa 7-26, 36-55, 62-84 and 94-116
316401003645	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
316401003646	GSH binding site [chemical binding]; other site
316401003647	catalytic residues [active]
316401003648	PS00195 Glutaredoxin active site.
316401003649	Protein of unknown function (DUF1418); Region: DUF1418; pfam07214
316401003650	2 probable transmembrane helices predicted for ETEC0917 by TMHMM2.0 at aa 7-29 and 44-66
316401003651	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
316401003652	dimer interface [polypeptide binding]; other site
316401003653	FMN binding site [chemical binding]; other site
316401003654	NADPH bind site [chemical binding]; other site
316401003655	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
316401003656	RimK-like ATP-grasp domain; Region: RimK; pfam08443
316401003657	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
316401003658	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
316401003659	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
316401003660	Signal peptide predicted for ETEC0921 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.946 between residues 26 and 27
316401003661	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
316401003662	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316401003663	Walker A/P-loop; other site
316401003664	ATP binding site [chemical binding]; other site
316401003665	Q-loop/lid; other site
316401003666	ABC transporter signature motif; other site
316401003667	Walker B; other site
316401003668	D-loop; other site
316401003669	H-loop/switch region; other site
316401003670	TOBE domain; Region: TOBE_2; pfam08402
316401003671	PS00017 ATP/GTP-binding site motif A (P-loop).
316401003672	PS00211 ABC transporters family signature.
316401003673	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
316401003674	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401003675	dimer interface [polypeptide binding]; other site
316401003676	conserved gate region; other site
316401003677	putative PBP binding loops; other site
316401003678	ABC-ATPase subunit interface; other site
316401003679	PS00133 Zinc carboxypeptidases, zinc-binding region 2 signature.
316401003680	6 probable transmembrane helices predicted for ETEC0923 by TMHMM2.0 at aa 31-52, 100-122, 135-157, 186-208, 229-251 and 284-306
316401003681	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
316401003682	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
316401003683	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401003684	dimer interface [polypeptide binding]; other site
316401003685	conserved gate region; other site
316401003686	putative PBP binding loops; other site
316401003687	ABC-ATPase subunit interface; other site
316401003688	6 probable transmembrane helices predicted for ETEC0924 by TMHMM2.0 at aa 13-35, 69-91, 104-126, 141-163, 184-206 and 242-264
316401003689	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
316401003690	Protein of unknown function (DUF2593); Region: DUF2593; pfam10767
316401003691	4 probable transmembrane helices predicted for ETEC0925 by TMHMM2.0 at aa 21-43, 65-87, 94-116 and 131-153
316401003692	23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085
316401003693	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316401003694	S-adenosylmethionine binding site [chemical binding]; other site
316401003695	PS01230 RNA methyltransferase trmA family signature 1.
316401003696	PS01231 RNA methyltransferase trmA family signature 2.
316401003697	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
316401003698	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
316401003699	substrate binding pocket [chemical binding]; other site
316401003700	membrane-bound complex binding site; other site
316401003701	hinge residues; other site
316401003702	PS01039 Bacterial extracellular solute-binding proteins, family 3 signature.
316401003703	Signal peptide predicted for ETEC0927 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.994 between residues 19 and 20
316401003704	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401003705	dimer interface [polypeptide binding]; other site
316401003706	conserved gate region; other site
316401003707	putative PBP binding loops; other site
316401003708	ABC-ATPase subunit interface; other site
316401003709	5 probable transmembrane helices predicted for ETEC0928 by TMHMM2.0 at aa 15-37, 46-68, 83-105, 155-174 and 189-211
316401003710	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
316401003711	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401003712	dimer interface [polypeptide binding]; other site
316401003713	conserved gate region; other site
316401003714	putative PBP binding loops; other site
316401003715	ABC-ATPase subunit interface; other site
316401003716	4 probable transmembrane helices predicted for ETEC0929 by TMHMM2.0 at aa 10-32, 45-67, 101-118 and 201-223
316401003717	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
316401003718	Signal peptide predicted for ETEC0929 by SignalP 2.0 HMM (Signal peptide probability 0.983) with cleavage site probability 0.696 between residues 29 and 30
316401003719	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
316401003720	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
316401003721	substrate binding pocket [chemical binding]; other site
316401003722	membrane-bound complex binding site; other site
316401003723	hinge residues; other site
316401003724	PS01039 Bacterial extracellular solute-binding proteins, family 3 signature.
316401003725	Signal peptide predicted for ETEC0930 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 19 and 20
316401003726	arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124
316401003727	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316401003728	Walker A/P-loop; other site
316401003729	ATP binding site [chemical binding]; other site
316401003730	Q-loop/lid; other site
316401003731	ABC transporter signature motif; other site
316401003732	Walker B; other site
316401003733	D-loop; other site
316401003734	H-loop/switch region; other site
316401003735	PS00211 ABC transporters family signature.
316401003736	PS00017 ATP/GTP-binding site motif A (P-loop).
316401003737	putative lipoprotein; Provisional; Region: PRK10533
316401003738	Signal peptide predicted for ETEC0932 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.792 between residues 27 and 28
316401003739	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401003740	hypothetical protein; Provisional; Region: PRK02877
316401003741	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
316401003742	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
316401003743	amidase catalytic site [active]
316401003744	Zn binding residues [ion binding]; other site
316401003745	substrate binding site [chemical binding]; other site
316401003746	Signal peptide predicted for ETEC0934 by SignalP 2.0 HMM (Signal peptide probability 0.955) with cleavage site probability 0.433 between residues 20 and 21
316401003747	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401003748	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
316401003749	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
316401003750	NAD(P) binding site [chemical binding]; other site
316401003751	active site
316401003752	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
316401003753	atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245
316401003754	putative NAD(P) binding site [chemical binding]; other site
316401003755	putative active site [active]
316401003756	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
316401003757	1 probable transmembrane helix predicted for ETEC0936 by TMHMM2.0 at aa 438-460
316401003758	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
316401003759	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
316401003760	tetramer interface [polypeptide binding]; other site
316401003761	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316401003762	catalytic residue [active]
316401003763	pyruvate dehydrogenase; Provisional; Region: PRK09124
316401003764	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
316401003765	PYR/PP interface [polypeptide binding]; other site
316401003766	dimer interface [polypeptide binding]; other site
316401003767	tetramer interface [polypeptide binding]; other site
316401003768	TPP binding site [chemical binding]; other site
316401003769	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
316401003770	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
316401003771	TPP-binding site [chemical binding]; other site
316401003772	PS00187 Thiamine pyrophosphate enzymes signature.
316401003773	HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684
316401003774	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
316401003775	FAD binding pocket [chemical binding]; other site
316401003776	FAD binding motif [chemical binding]; other site
316401003777	phosphate binding motif [ion binding]; other site
316401003778	beta-alpha-beta structure motif; other site
316401003779	NAD binding pocket [chemical binding]; other site
316401003780	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
316401003781	catalytic loop [active]
316401003782	iron binding site [ion binding]; other site
316401003783	hybrid cluster protein; Provisional; Region: PRK05290
316401003784	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
316401003785	ACS interaction site; other site
316401003786	CODH interaction site; other site
316401003787	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
316401003788	hybrid metal cluster; other site
316401003789	PS00017 ATP/GTP-binding site motif A (P-loop).
316401003790	Predicted membrane protein [Function unknown]; Region: COG2431
316401003791	8 probable transmembrane helices predicted for ETEC0941 by TMHMM2.0 at aa 4-20, 32-51, 61-83, 111-133, 138-155, 167-189, 204-226 and 276-298
316401003792	PS00041 Bacterial regulatory proteins, araC family signature.
316401003793	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
316401003794	amphipathic channel; other site
316401003795	Asn-Pro-Ala signature motifs; other site
316401003796	6 probable transmembrane helices predicted for ETEC0942 by TMHMM2.0 at aa 7-29, 33-55, 81-103, 127-149, 156-178 and 205-227
316401003797	PS00501 Signal peptidases I serine active site.
316401003798	PS00221 MIP family signature.
316401003799	Signal peptide predicted for ETEC0942 by SignalP 2.0 HMM (Signal peptide probability 0.985) with cleavage site probability 0.967 between residues 26 and 27
316401003800	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401003801	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
316401003802	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
316401003803	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
316401003804	putative active site [active]
316401003805	putative metal-binding site [ion binding]; other site
316401003806	PS00017 ATP/GTP-binding site motif A (P-loop).
316401003807	Protein of unknown function (DUF535); Region: DUF535; pfam04393
316401003808	macrolide transporter subunit MacA; Provisional; Region: PRK11578
316401003809	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
316401003810	HlyD family secretion protein; Region: HlyD_3; pfam13437
316401003811	Signal peptide predicted for ETEC0945 by SignalP 2.0 HMM (Signal peptide probability 0.752) with cleavage site probability 0.731 between residues 30 and 31
316401003812	1 probable transmembrane helix predicted for ETEC0945 by TMHMM2.0 at aa 12-29
316401003813	Similar to C-terminus of Escherichia coli o1:k1/apec. macb1 UniProt:A1A9B7 (EMBL:CP000468 (648 aa) fasta scores: E()=2.1e-137, 100.000% id in 389 aa
316401003815	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
316401003816	DNA-binding site [nucleotide binding]; DNA binding site
316401003817	RNA-binding motif; other site
316401003818	PS00352 'Cold-shock' DNA-binding domain signature.
316401003819	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
316401003820	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
316401003821	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316401003822	Walker A motif; other site
316401003823	ATP binding site [chemical binding]; other site
316401003824	Walker B motif; other site
316401003825	arginine finger; other site
316401003826	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316401003827	Walker A motif; other site
316401003828	ATP binding site [chemical binding]; other site
316401003829	Walker B motif; other site
316401003830	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
316401003831	PS00017 ATP/GTP-binding site motif A (P-loop).
316401003832	PS00870 Chaperonins clpA/B signature 1.
316401003833	PS00017 ATP/GTP-binding site motif A (P-loop).
316401003834	PS00871 Chaperonins clpA/B signature 2.
316401003835	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
316401003836	rRNA binding site [nucleotide binding]; other site
316401003837	predicted 30S ribosome binding site; other site
316401003838	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
316401003839	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
316401003840	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
316401003841	ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247
316401003842	Walker A/P-loop; other site
316401003843	ATP binding site [chemical binding]; other site
316401003844	Q-loop/lid; other site
316401003845	ABC transporter signature motif; other site
316401003846	Walker B; other site
316401003847	D-loop; other site
316401003848	H-loop/switch region; other site
316401003849	PS00211 ABC transporters family signature.
316401003850	PS00017 ATP/GTP-binding site motif A (P-loop).
316401003851	6 probable transmembrane helices predicted for ETEC0954 by TMHMM2.0 at aa 20-42, 47-69, 133-155, 160-182, 246-268 and 278-300
316401003852	Signal peptide predicted for ETEC0954 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.891 between residues 49 and 50
316401003853	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174
316401003854	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
316401003855	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316401003856	Walker A/P-loop; other site
316401003857	ATP binding site [chemical binding]; other site
316401003858	Q-loop/lid; other site
316401003859	ABC transporter signature motif; other site
316401003860	Walker B; other site
316401003861	D-loop; other site
316401003862	H-loop/switch region; other site
316401003863	PS00211 ABC transporters family signature.
316401003864	PS00017 ATP/GTP-binding site motif A (P-loop).
316401003865	5 probable transmembrane helices predicted for ETEC0955 by TMHMM2.0 at aa 24-46, 61-80, 137-159, 163-185 and 246-268
316401003866	thioredoxin reductase; Provisional; Region: PRK10262
316401003867	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
316401003868	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
316401003869	PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site.
316401003870	Signal peptide predicted for ETEC0956 by SignalP 2.0 HMM (Signal peptide probability 0.987) with cleavage site probability 0.968 between residues 25 and 26
316401003871	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
316401003872	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
316401003873	putative DNA binding site [nucleotide binding]; other site
316401003874	putative Zn2+ binding site [ion binding]; other site
316401003875	AsnC family; Region: AsnC_trans_reg; pfam01037
316401003876	PS00519 Bacterial regulatory proteins, asnC family signature.
316401003877	DNA translocase FtsK; Provisional; Region: PRK10263
316401003878	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
316401003879	DNA translocase FtsK; Provisional; Region: PRK10263
316401003880	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
316401003881	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
316401003882	5 probable transmembrane helices predicted for ETEC0958 by TMHMM2.0 at aa 22-44, 75-97, 110-132, 137-158 and 165-187
316401003883	PS00017 ATP/GTP-binding site motif A (P-loop).
316401003884	periplasmic chaperone LolA; Region: lolA; TIGR00547
316401003885	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
316401003886	Signal peptide predicted for ETEC0959 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.995 between residues 22 and 23
316401003887	recombination factor protein RarA; Reviewed; Region: PRK13342
316401003888	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316401003889	Walker A motif; other site
316401003890	ATP binding site [chemical binding]; other site
316401003891	Walker B motif; other site
316401003892	arginine finger; other site
316401003893	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
316401003894	PS00017 ATP/GTP-binding site motif A (P-loop).
316401003895	seryl-tRNA synthetase; Provisional; Region: PRK05431
316401003896	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
316401003897	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
316401003898	dimer interface [polypeptide binding]; other site
316401003899	active site
316401003900	motif 1; other site
316401003901	motif 2; other site
316401003902	motif 3; other site
316401003903	PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1.
316401003904	anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990
316401003905	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
316401003906	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
316401003907	putative [Fe4-S4] binding site [ion binding]; other site
316401003908	putative molybdopterin cofactor binding site [chemical binding]; other site
316401003909	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
316401003910	putative molybdopterin cofactor binding site; other site
316401003911	Signal peptide predicted for ETEC0962 by SignalP 2.0 HMM (Signal peptide probability 0.981) with cleavage site probability 0.971 between residues 45 and 46
316401003912	PS00551 Prokaryotic molybdopterin oxidoreductases signature 1.
316401003913	PS00490 Prokaryotic molybdopterin oxidoreductases signature 2.
316401003914	PS00932 Prokaryotic molybdopterin oxidoreductases signature 3.
316401003915	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
316401003916	4Fe-4S binding domain; Region: Fer4; pfam00037
316401003917	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401003918	PS00190 Cytochrome c family heme-binding site signature.
316401003919	DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976
316401003920	8 probable transmembrane helices predicted for ETEC0964 by TMHMM2.0 at aa 10-32, 45-67, 82-104, 117-134, 149-171, 184-206, 226-243 and 255-277
316401003921	Isochorismatase family; Region: Isochorismatase; pfam00857
316401003922	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
316401003923	catalytic triad [active]
316401003924	dimer interface [polypeptide binding]; other site
316401003925	conserved cis-peptide bond; other site
316401003926	putative MFS family transporter protein; Provisional; Region: PRK03633
316401003927	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401003928	putative substrate translocation pore; other site
316401003929	Signal peptide predicted for ETEC0966 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.763 between residues 23 and 24
316401003930	12 probable transmembrane helices predicted for ETEC0966 by TMHMM2.0 at aa 7-29, 44-66, 73-92, 97-119, 131-150, 160-182, 204-226, 236-258, 265-282, 286-308, 320-342 and 352-369
316401003931	PS00237 G-protein coupled receptors signature.
316401003932	PS00225 Crystallins beta and gamma 'Greek key' motif signature.
316401003933	Amino acid permease; Region: AA_permease_2; pfam13520
316401003934	12 probable transmembrane helices predicted for ETEC0967 by TMHMM2.0 at aa 12-34, 38-60, 73-95, 128-147, 159-181, 196-218, 239-261, 288-310, 341-363, 378-400, 413-435 and 445-467
316401003935	Transcriptional regulator [Transcription]; Region: LysR; COG0583
316401003936	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401003937	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
316401003938	putative effector binding pocket; other site
316401003939	putative dimerization interface [polypeptide binding]; other site
316401003940	PS00044 Bacterial regulatory proteins, lysR family signature.
316401003941	hypothetical protein; Provisional; Region: PRK09739
316401003942	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
316401003943	pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145
316401003944	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316401003945	FeS/SAM binding site; other site
316401003946	PS01087 Radical activating enzymes signature.
316401003947	PS00190 Cytochrome c family heme-binding site signature.
316401003948	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
316401003949	Pyruvate formate lyase 1; Region: PFL1; cd01678
316401003950	coenzyme A binding site [chemical binding]; other site
316401003951	active site
316401003952	catalytic residues [active]
316401003953	glycine loop; other site
316401003954	PS00850 Glycine radical signature.
316401003955	formate transporter; Provisional; Region: PRK10805
316401003956	6 probable transmembrane helices predicted for ETEC0972 by TMHMM2.0 at aa 35-57, 77-99, 119-141, 161-183, 195-217 and 256-278
316401003957	PS01006 Formate and nitrite transporters signature 2.
316401003958	PS01005 Formate and nitrite transporters signature 1.
316401003959	uncharacterized domain; Region: TIGR00702
316401003960	YcaO-like family; Region: YcaO; pfam02624
316401003961	Predicted membrane protein [Function unknown]; Region: COG2323
316401003962	3 probable transmembrane helices predicted for ETEC0974 by TMHMM2.0 at aa 15-37, 50-69 and 74-91
316401003963	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
316401003964	homodimer interface [polypeptide binding]; other site
316401003965	substrate-cofactor binding pocket; other site
316401003966	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316401003967	catalytic residue [active]
316401003968	PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site.
316401003969	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
316401003970	Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554
316401003971	hinge; other site
316401003972	active site
316401003973	PS00017 ATP/GTP-binding site motif A (P-loop).
316401003974	PS00104 EPSP synthase signature 1.
316401003975	PS00885 EPSP synthase signature 2.
316401003976	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
316401003977	Signal peptide predicted for ETEC0977 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.772 between residues 25 and 26
316401003978	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401003979	cytidylate kinase; Provisional; Region: cmk; PRK00023
316401003980	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
316401003981	CMP-binding site; other site
316401003982	The sites determining sugar specificity; other site
316401003983	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
316401003984	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
316401003985	RNA binding site [nucleotide binding]; other site
316401003986	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
316401003987	RNA binding site [nucleotide binding]; other site
316401003988	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
316401003989	RNA binding site [nucleotide binding]; other site
316401003990	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
316401003991	RNA binding site [nucleotide binding]; other site
316401003992	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
316401003993	RNA binding site [nucleotide binding]; other site
316401003994	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
316401003995	IHF dimer interface [polypeptide binding]; other site
316401003996	IHF - DNA interface [nucleotide binding]; other site
316401003997	PS00045 Bacterial histone-like DNA-binding proteins signature.
316401003998	ComEC family competence protein; Provisional; Region: PRK11539
316401003999	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
316401004000	ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360
316401004001	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
316401004002	7 probable transmembrane helices predicted for ETEC0981 by TMHMM2.0 at aa 7-29, 39-61, 222-244, 254-276, 322-344, 359-381 and 388-410
316401004003	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401004004	lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176
316401004005	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
316401004006	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
316401004007	Walker A/P-loop; other site
316401004008	ATP binding site [chemical binding]; other site
316401004009	Q-loop/lid; other site
316401004010	ABC transporter signature motif; other site
316401004011	Walker B; other site
316401004012	D-loop; other site
316401004013	H-loop/switch region; other site
316401004014	Signal peptide predicted for ETEC0982 by SignalP 2.0 HMM (Signal peptide probability 0.612) with cleavage site probability 0.358 between residues 38 and 39
316401004015	5 probable transmembrane helices predicted for ETEC0982 by TMHMM2.0 at aa 21-43, 63-85, 141-163, 167-186 and 245-267
316401004016	PS00017 ATP/GTP-binding site motif A (P-loop).
316401004017	PS00211 ABC transporters family signature.
316401004018	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
316401004019	tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682
316401004020	1 probable transmembrane helix predicted for ETEC0983 by TMHMM2.0 at aa 15-34
316401004021	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
316401004022	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
316401004023	hypothetical protein; Provisional; Region: PRK11827
316401004024	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
316401004025	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
316401004026	Ligand binding site; other site
316401004027	oligomer interface; other site
316401004028	hypothetical protein; Provisional; Region: PRK10593
316401004029	Uncharacterized conserved protein [Function unknown]; Region: COG1434
316401004030	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
316401004031	putative active site [active]
316401004032	2 probable transmembrane helices predicted for ETEC0988 by TMHMM2.0 at aa 10-32 and 39-58
316401004033	Signal peptide predicted for ETEC0988 by SignalP 2.0 HMM (Signal peptide probability 0.886) with cleavage site probability 0.429 between residues 36 and 37
316401004034	Methyltransferase domain; Region: Methyltransf_31; pfam13847
316401004035	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316401004036	S-adenosylmethionine binding site [chemical binding]; other site
316401004037	PS00017 ATP/GTP-binding site motif A (P-loop).
316401004038	condesin subunit F; Provisional; Region: PRK05260
316401004039	condesin subunit E; Provisional; Region: PRK05256
316401004040	Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096
316401004041	MukB N-terminal; Region: MukB; pfam04310
316401004042	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
316401004043	PS00017 ATP/GTP-binding site motif A (P-loop).
316401004044	murein L,D-transpeptidase; Provisional; Region: PRK10594
316401004045	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
316401004046	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
316401004047	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
316401004048	Signal peptide predicted for ETEC0993 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.995 between residues 30 and 31
316401004049	PS00092 N-6 Adenine-specific DNA methylases signature.
316401004050	PS00225 Crystallins beta and gamma 'Greek key' motif signature.
316401004051	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
316401004052	Peptidase M15; Region: Peptidase_M15_3; cl01194
316401004053	Signal peptide predicted for ETEC0994 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 30 and 31
316401004054	1 probable transmembrane helix predicted for ETEC0994 by TMHMM2.0 at aa 12-34
316401004055	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
316401004056	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
316401004057	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
316401004058	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316401004059	homodimer interface [polypeptide binding]; other site
316401004060	catalytic residue [active]
316401004061	PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site.
316401004062	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
316401004063	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
316401004064	trimer interface [polypeptide binding]; other site
316401004065	eyelet of channel; other site
316401004066	PS00576 General diffusion Gram-negative porins signature.
316401004067	Signal peptide predicted for ETEC0997 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 22 and 23
316401004068	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
316401004069	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
316401004070	putative dimer interface [polypeptide binding]; other site
316401004071	putative anticodon binding site; other site
316401004072	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
316401004073	homodimer interface [polypeptide binding]; other site
316401004074	motif 1; other site
316401004075	motif 2; other site
316401004076	active site
316401004077	motif 3; other site
316401004078	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
316401004079	PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1.
316401004080	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
316401004081	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
316401004082	active site
316401004083	aminopeptidase N; Provisional; Region: pepN; PRK14015
316401004084	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
316401004085	active site
316401004086	Zn binding site [ion binding]; other site
316401004087	PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.
316401004088	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
316401004089	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
316401004090	Walker A/P-loop; other site
316401004091	ATP binding site [chemical binding]; other site
316401004092	Q-loop/lid; other site
316401004093	ABC transporter signature motif; other site
316401004094	Walker B; other site
316401004095	D-loop; other site
316401004096	H-loop/switch region; other site
316401004097	PS00211 ABC transporters family signature.
316401004098	PS00017 ATP/GTP-binding site motif A (P-loop).
316401004099	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
316401004100	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401004101	dimer interface [polypeptide binding]; other site
316401004102	conserved gate region; other site
316401004103	putative PBP binding loops; other site
316401004104	ABC-ATPase subunit interface; other site
316401004105	7 probable transmembrane helices predicted for ETEC1002 by TMHMM2.0 at aa 12-34, 68-90, 103-122, 126-148, 161-183, 188-210 and 223-245
316401004106	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
316401004107	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
316401004108	active site
316401004109	dimer interface [polypeptide binding]; other site
316401004110	non-prolyl cis peptide bond; other site
316401004111	insertion regions; other site
316401004112	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
316401004113	substrate binding pocket [chemical binding]; other site
316401004114	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
316401004115	membrane-bound complex binding site; other site
316401004116	hinge residues; other site
316401004117	Signal peptide predicted for ETEC1004 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.914 between residues 21 and 22
316401004118	NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569
316401004119	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
316401004120	Fimbrial protein; Region: Fimbrial; cl01416
316401004121	Signal peptide predicted for ETEC1006 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 21 and 22
316401004122	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
316401004123	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
316401004124	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
316401004125	Signal peptide predicted for ETEC1007 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 26 and 27
316401004126	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401004127	outer membrane usher protein; Provisional; Region: PRK15193
316401004128	PapC N-terminal domain; Region: PapC_N; pfam13954
316401004129	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
316401004130	PapC C-terminal domain; Region: PapC_C; pfam13953
316401004131	Signal peptide predicted for ETEC1008 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.923 between residues 35 and 36
316401004132	1 probable transmembrane helix predicted for ETEC1008 by TMHMM2.0 at aa 9-31
316401004133	PS01151 Fimbrial biogenesis outer membrane usher protein signature.
316401004134	PS00017 ATP/GTP-binding site motif A (P-loop).
316401004135	Transposase; Region: HTH_Tnp_1; pfam01527
316401004136	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
316401004137	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
316401004138	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
316401004139	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
316401004140	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
316401004141	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
316401004142	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
316401004143	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
316401004144	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
316401004145	Fimbrial protein; Region: Fimbrial; cl01416
316401004146	Fimbrial protein; Region: Fimbrial; cl01416
316401004147	Signal peptide predicted for ETEC1012 by SignalP 2.0 HMM (Signal peptide probability 0.969) with cleavage site probability 0.966 between residues 24 and 25
316401004148	1 probable transmembrane helix predicted for ETEC1012 by TMHMM2.0 at aa 7-24
316401004149	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
316401004150	Signal peptide predicted for ETEC1013 by SignalP 2.0 HMM (Signal peptide probability 0.948) with cleavage site probability 0.944 between residues 22 and 23
316401004151	putativi pili assembly chaperone; Provisional; Region: PRK11385
316401004152	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
316401004153	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
316401004154	Signal peptide predicted for ETEC1014 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.815 between residues 26 and 27
316401004155	1 probable transmembrane helix predicted for ETEC1014 by TMHMM2.0 at aa 7-29
316401004156	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
316401004157	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
316401004158	quinone interaction residues [chemical binding]; other site
316401004159	active site
316401004160	catalytic residues [active]
316401004161	FMN binding site [chemical binding]; other site
316401004162	substrate binding site [chemical binding]; other site
316401004163	PS00911 Dihydroorotate dehydrogenase signature 1.
316401004164	PS00912 Dihydroorotate dehydrogenase signature 2.
316401004165	Protein of unknown function (DUF1379); Region: DUF1379; pfam07126
316401004166	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
316401004167	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
316401004168	MOSC domain; Region: MOSC; pfam03473
316401004169	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
316401004170	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
316401004171	catalytic loop [active]
316401004172	iron binding site [ion binding]; other site
316401004173	PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature.
316401004174	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
316401004175	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
316401004176	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
316401004177	Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170
316401004178	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316401004179	S-adenosylmethionine binding site [chemical binding]; other site
316401004180	PS01261 Uncharacterized protein family UPF0020 signature.
316401004181	PS00092 N-6 Adenine-specific DNA methylases signature.
316401004182	ABC transporter ATPase component; Reviewed; Region: PRK11147
316401004183	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316401004184	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316401004185	Walker A/P-loop; other site
316401004186	Walker A/P-loop; other site
316401004187	ATP binding site [chemical binding]; other site
316401004188	ATP binding site [chemical binding]; other site
316401004189	Q-loop/lid; other site
316401004190	Q-loop/lid; other site
316401004191	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
316401004192	ABC transporter signature motif; other site
316401004193	Walker B; other site
316401004194	D-loop; other site
316401004195	ABC transporter; Region: ABC_tran_2; pfam12848
316401004196	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
316401004197	PS00017 ATP/GTP-binding site motif A (P-loop).
316401004198	PS00211 ABC transporters family signature.
316401004199	PS00017 ATP/GTP-binding site motif A (P-loop).
316401004200	PS00211 ABC transporters family signature.
316401004201	paraquat-inducible membrane protein A; Provisional; Region: PRK15103
316401004202	Paraquat-inducible protein A; Region: PqiA; pfam04403
316401004203	Paraquat-inducible protein A; Region: PqiA; pfam04403
316401004204	8 probable transmembrane helices predicted for ETEC1020 by TMHMM2.0 at aa 53-75, 100-122, 135-157, 162-184, 255-277, 304-326, 350-372 and 377-399
316401004205	paraquat-inducible protein B; Provisional; Region: PRK10807
316401004206	mce related protein; Region: MCE; pfam02470
316401004207	mce related protein; Region: MCE; pfam02470
316401004208	mce related protein; Region: MCE; pfam02470
316401004209	DASH complex subunit Duo1; Region: DASH_Duo1; pfam08651
316401004210	1 probable transmembrane helix predicted for ETEC1021 by TMHMM2.0 at aa 16-38
316401004211	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
316401004212	Protein of unknown function (DUF330); Region: DUF330; pfam03886
316401004213	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401004214	ribosome modulation factor; Provisional; Region: PRK14563
316401004215	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
316401004216	active site 1 [active]
316401004217	dimer interface [polypeptide binding]; other site
316401004218	active site 2 [active]
316401004219	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
316401004220	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
316401004221	Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097
316401004222	outer membrane protein A; Reviewed; Region: PRK10808
316401004223	OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389
316401004224	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
316401004225	ligand binding site [chemical binding]; other site
316401004226	PS01068 OmpA-like domain.
316401004227	Signal peptide predicted for ETEC1027 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.947 between residues 21 and 22
316401004228	cell division inhibitor SulA; Region: sula; TIGR00623
316401004229	Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070
316401004230	TfoX C-terminal domain; Region: TfoX_C; pfam04994
316401004231	TIGR01666 family membrane protein; Region: YCCS
316401004232	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
316401004233	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
316401004234	9 probable transmembrane helices predicted for ETEC1030 by TMHMM2.0 at aa 13-35, 86-108, 115-137, 141-163, 398-420, 440-459, 466-483, 488-510 and 517-534
316401004235	PS00217 Sugar transport proteins signature 2.
316401004236	Predicted membrane protein [Function unknown]; Region: COG3304
316401004237	Domain of unknown function (DUF307); Region: DUF307; pfam03733
316401004238	Domain of unknown function (DUF307); Region: DUF307; pfam03733
316401004239	3 probable transmembrane helices predicted for ETEC1031 by TMHMM2.0 at aa 15-37, 77-99 and 103-125
316401004240	DNA helicase IV; Provisional; Region: helD; PRK11054
316401004241	DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462
316401004242	Part of AAA domain; Region: AAA_19; pfam13245
316401004243	Family description; Region: UvrD_C_2; pfam13538
316401004244	PS00017 ATP/GTP-binding site motif A (P-loop).
316401004245	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
316401004246	active site
316401004247	dimer interfaces [polypeptide binding]; other site
316401004248	catalytic residues [active]
316401004249	PS01335 Methylglyoxal synthase active site.
316401004250	hypothetical protein; Provisional; Region: PRK03641
316401004251	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110
316401004252	Signal peptide predicted for ETEC1034 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.996 between residues 20 and 21
316401004253	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
316401004254	heat shock protein HspQ; Provisional; Region: PRK14129
316401004255	23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128
316401004256	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
316401004257	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
316401004258	putative RNA binding site [nucleotide binding]; other site
316401004259	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316401004260	S-adenosylmethionine binding site [chemical binding]; other site
316401004261	PS00294 Prenyl group binding site (CAAX box).
316401004262	Acylphosphatase; Region: Acylphosphatase; cl00551
316401004263	PS00150 Acylphosphatase signature 1.
316401004264	PS00151 Acylphosphatase signature 2.
316401004265	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
316401004266	sulfur transfer protein TusE; Provisional; Region: PRK11508
316401004267	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
316401004268	YccA-like proteins; Region: YccA_like; cd10433
316401004269	7 probable transmembrane helices predicted for ETEC1040 by TMHMM2.0 at aa 21-40, 45-67, 74-96, 106-125, 132-154, 159-181 and 194-216
316401004270	PS01243 Uncharacterized protein family UPF0005 signature.
316401004271	Signal peptide predicted for ETEC1040 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.937 between residues 41 and 42
316401004272	hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391
316401004273	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
316401004274	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
316401004275	Signal peptide predicted for ETEC1041 by SignalP 2.0 HMM (Signal peptide probability 0.632) with cleavage site probability 0.631 between residues 45 and 46
316401004276	2 probable transmembrane helices predicted for ETEC1041 by TMHMM2.0 at aa 20-39 and 326-348
316401004277	hydrogenase 1 large subunit; Provisional; Region: PRK10170
316401004278	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
316401004279	PS00507 Nickel-dependent hydrogenases large subunit signature 1.
316401004280	PS00508 Nickel-dependent hydrogenases large subunit signature 2.
316401004281	hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171
316401004282	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
316401004283	PS00882 Nickel-dependent hydrogenases b-type cytochrome subunit signature 1.
316401004284	4 probable transmembrane helices predicted for ETEC1043 by TMHMM2.0 at aa 20-39, 59-81, 128-150 and 186-203
316401004285	PS00883 Nickel-dependent hydrogenases b-type cytochrome subunit signature 2.
316401004286	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
316401004287	putative substrate-binding site; other site
316401004288	nickel binding site [ion binding]; other site
316401004289	HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965
316401004290	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
316401004291	cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035
316401004292	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
316401004293	9 probable transmembrane helices predicted for ETEC1047 by TMHMM2.0 at aa 20-42, 54-76, 96-118, 125-147, 186-208, 215-237, 387-409, 421-443 and 466-488
316401004294	cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028
316401004295	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
316401004296	8 probable transmembrane helices predicted for ETEC1048 by TMHMM2.0 at aa 7-24, 78-100, 121-143, 166-188, 209-231, 263-285, 292-314 and 334-356
316401004297	glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173
316401004298	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
316401004299	catalytic core [active]
316401004300	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
316401004301	Signal peptide predicted for ETEC1049 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 22 and 23
316401004302	PS00616 Histidine acid phosphatases phosphohistidine signature.
316401004303	PS00778 Histidine acid phosphatases active site signature.
316401004304	cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841
316401004305	Chain length determinant protein; Region: Wzz; pfam02706
316401004306	Chain length determinant protein; Region: Wzz; cl15801
316401004307	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
316401004308	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
316401004309	Nucleotide binding site [chemical binding]; other site
316401004310	PS00017 ATP/GTP-binding site motif A (P-loop).
316401004311	2 probable transmembrane helices predicted for ETEC1050 by TMHMM2.0 at aa 33-52 and 425-447
316401004312	Low molecular weight phosphatase family; Region: LMWPc; cd00115
316401004313	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
316401004314	active site
316401004315	PS00017 ATP/GTP-binding site motif A (P-loop).
316401004316	polysaccharide export protein Wza; Provisional; Region: PRK15078
316401004317	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
316401004318	SLBB domain; Region: SLBB; pfam10531
316401004319	SLBB domain; Region: SLBB; pfam10531
316401004320	Signal peptide predicted for ETEC1052 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.372 between residues 22 and 23
316401004321	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401004322	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
316401004323	Signal peptide predicted for ETEC1053 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 21 and 22
316401004324	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401004325	Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251
316401004326	Signal peptide predicted for ETEC1054 by SignalP 2.0 HMM (Signal peptide probability 0.990) with cleavage site probability 0.984 between residues 22 and 23
316401004327	Protein of unknown function (DUF2886); Region: DUF2886; pfam11102
316401004328	Signal peptide predicted for ETEC1055 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.458 between residues 24 and 25
316401004329	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401004330	2 probable transmembrane helices predicted for ETEC1056 by TMHMM2.0 at aa 5-22 and 59-81
316401004331	Signal peptide predicted for ETEC1056 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 21 and 22
316401004332	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
316401004333	DNA-binding site [nucleotide binding]; DNA binding site
316401004334	RNA-binding motif; other site
316401004335	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
316401004336	DNA-binding site [nucleotide binding]; DNA binding site
316401004337	RNA-binding motif; other site
316401004338	PS00352 'Cold-shock' DNA-binding domain signature.
316401004339	cold shock gene; Provisional; Region: PRK09891
316401004340	Signal peptide predicted for ETEC1059 by SignalP 2.0 HMM (Signal peptide probability 0.631) with cleavage site probability 0.500 between residues 31 and 32
316401004341	1 probable transmembrane helix predicted for ETEC1059 by TMHMM2.0 at aa 16-38
316401004342	GnsA/GnsB family; Region: GnsAB; pfam08178
316401004343	quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477
316401004344	4Fe-4S binding domain; Region: Fer4_5; pfam12801
316401004345	4Fe-4S binding domain; Region: Fer4_5; pfam12801
316401004346	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
316401004347	5 probable transmembrane helices predicted for ETEC1061 by TMHMM2.0 at aa 37-54, 92-114, 159-181, 196-218 and 310-332
316401004348	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401004349	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401004350	hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466
316401004351	HAMP domain; Region: HAMP; pfam00672
316401004352	dimerization interface [polypeptide binding]; other site
316401004353	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316401004354	dimer interface [polypeptide binding]; other site
316401004355	phosphorylation site [posttranslational modification]
316401004356	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316401004357	ATP binding site [chemical binding]; other site
316401004358	Mg2+ binding site [ion binding]; other site
316401004359	G-X-G motif; other site
316401004360	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316401004361	active site
316401004362	phosphorylation site [posttranslational modification]
316401004363	intermolecular recognition site; other site
316401004364	dimerization interface [polypeptide binding]; other site
316401004365	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
316401004366	putative binding surface; other site
316401004367	active site
316401004368	PS00687 Aldehyde dehydrogenases glutamic acid active site.
316401004369	2 probable transmembrane helices predicted for ETEC1062 by TMHMM2.0 at aa 10-32 and 331-353
316401004370	Signal peptide predicted for ETEC1062 by SignalP 2.0 HMM (Signal peptide probability 0.987) with cleavage site probability 0.594 between residues 26 and 27
316401004371	TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936
316401004372	TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306
316401004373	putative ligand binding site [chemical binding]; other site
316401004374	Signal peptide predicted for ETEC1063 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 18 and 19
316401004375	DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766
316401004376	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316401004377	active site
316401004378	phosphorylation site [posttranslational modification]
316401004379	intermolecular recognition site; other site
316401004380	dimerization interface [polypeptide binding]; other site
316401004381	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
316401004382	DNA binding site [nucleotide binding]
316401004383	trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032
316401004384	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
316401004385	1 probable transmembrane helix predicted for ETEC1065 by TMHMM2.0 at aa 17-39
316401004386	PS00190 Cytochrome c family heme-binding site signature.
316401004387	PS00190 Cytochrome c family heme-binding site signature.
316401004388	PS00190 Cytochrome c family heme-binding site signature.
316401004389	PS00190 Cytochrome c family heme-binding site signature.
316401004390	trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102
316401004391	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
316401004392	molybdopterin cofactor binding site [chemical binding]; other site
316401004393	substrate binding site [chemical binding]; other site
316401004394	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
316401004395	molybdopterin cofactor binding site; other site
316401004396	Signal peptide predicted for ETEC1066 by SignalP 2.0 HMM (Signal peptide probability 0.957) with cleavage site probability 0.885 between residues 39 and 40
316401004397	PS00490 Prokaryotic molybdopterin oxidoreductases signature 2.
316401004398	PS00932 Prokaryotic molybdopterin oxidoreductases signature 3.
316401004399	chaperone protein TorD; Validated; Region: torD; PRK04976
316401004400	chaperone-modulator protein CbpM; Provisional; Region: PRK10265
316401004401	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
316401004402	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
316401004403	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
316401004404	HSP70 interaction site [polypeptide binding]; other site
316401004405	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
316401004406	substrate binding site [polypeptide binding]; other site
316401004407	dimer interface [polypeptide binding]; other site
316401004408	PS00636 Nt-dnaJ domain signature.
316401004409	hypothetical protein; Provisional; Region: PRK09784
316401004410	glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173
316401004411	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
316401004412	catalytic core [active]
316401004413	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
316401004414	Signal peptide predicted for ETEC1071 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 22 and 23
316401004415	PS00616 Histidine acid phosphatases phosphohistidine signature.
316401004416	PS00778 Histidine acid phosphatases active site signature.
316401004417	hypothetical protein; Provisional; Region: PRK10174
316401004418	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
316401004419	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
316401004420	General stress protein [General function prediction only]; Region: GsiB; COG3729
316401004421	PS00017 ATP/GTP-binding site motif A (P-loop).
316401004422	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
316401004423	11 probable transmembrane helices predicted for ETEC1075 by TMHMM2.0 at aa 53-75, 82-99, 109-131, 144-163, 173-190, 197-219, 243-265, 285-307, 322-344, 351-373 and 399-421
316401004424	PS01116 Xanthine/uracil permeases family signature.
316401004425	pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615
316401004426	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
316401004427	putative FMN binding site [chemical binding]; other site
316401004428	PS00294 Prenyl group binding site (CAAX box).
316401004429	pyrimidine utilization protein D; Region: RutD; TIGR03611
316401004430	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
316401004431	homotrimer interaction site [polypeptide binding]; other site
316401004432	putative active site [active]
316401004433	PS01094 Uncharacterized protein family UPF0076 signature.
316401004434	Signal peptide predicted for ETEC1079 by SignalP 2.0 HMM (Signal peptide probability 0.899) with cleavage site probability 0.889 between residues 24 and 25
316401004435	pyrimidine utilization protein A; Region: RutA; TIGR03612
316401004436	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
316401004437	active site
316401004438	dimer interface [polypeptide binding]; other site
316401004439	non-prolyl cis peptide bond; other site
316401004440	insertion regions; other site
316401004441	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
316401004442	HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008
316401004443	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
316401004444	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
316401004445	trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809
316401004446	Predicted transcriptional regulator [Transcription]; Region: COG3905
316401004447	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
316401004448	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
316401004449	Glutamate binding site [chemical binding]; other site
316401004450	NAD binding site [chemical binding]; other site
316401004451	catalytic residues [active]
316401004452	PS00070 Aldehyde dehydrogenases cysteine active site.
316401004453	PS00687 Aldehyde dehydrogenases glutamic acid active site.
316401004454	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
316401004455	Na binding site [ion binding]; other site
316401004456	12 probable transmembrane helices predicted for ETEC1084 by TMHMM2.0 at aa 7-26, 66-88, 125-147, 162-184, 191-213, 233-255, 275-297, 329-351, 372-391, 401-423, 428-450 and 455-473
316401004457	PS00456 Sodium:solute symporter family signature 1.
316401004458	PS00457 Sodium:solute symporter family signature 2.
316401004459	FTR1 family protein; Region: TIGR00145
316401004460	7 probable transmembrane helices predicted for ETEC1085 by TMHMM2.0 at aa 10-29, 36-58, 73-92, 122-144, 154-176, 183-205 and 251-273
316401004461	PS00435 Peroxidases proximal heme-ligand signature.
316401004462	inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378
316401004463	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
316401004464	Imelysin; Region: Peptidase_M75; pfam09375
316401004465	Signal peptide predicted for ETEC1086 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 26 and 27
316401004466	Tat-translocated enzyme; Region: tat_substr_1; TIGR01412
316401004467	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
316401004468	Signal peptide predicted for ETEC1087 by SignalP 2.0 HMM (Signal peptide probability 0.991) with cleavage site probability 0.990 between residues 35 and 36
316401004469	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401004470	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
316401004471	hypothetical protein; Provisional; Region: PRK10536
316401004472	PS00017 ATP/GTP-binding site motif A (P-loop).
316401004473	putative PGA biosynthesis protein; Provisional; Region: pgaD; PRK14585
316401004474	2 probable transmembrane helices predicted for ETEC1089 by TMHMM2.0 at aa 13-35 and 55-74
316401004475	N-glycosyltransferase; Provisional; Region: PRK11204
316401004476	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
316401004477	DXD motif; other site
316401004478	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
316401004479	5 probable transmembrane helices predicted for ETEC1090 by TMHMM2.0 at aa 5-27, 33-55, 322-344, 359-381 and 393-415
316401004480	outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582
316401004481	N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964
316401004482	putative active site [active]
316401004483	putative metal binding site [ion binding]; other site
316401004484	PS00225 Crystallins beta and gamma 'Greek key' motif signature.
316401004485	Signal peptide predicted for ETEC1091 by SignalP 2.0 HMM (Signal peptide probability 0.970) with cleavage site probability 0.403 between residues 28 and 29
316401004486	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401004488	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
316401004489	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316401004490	metal binding site [ion binding]; metal-binding site
316401004491	active site
316401004492	I-site; other site
316401004493	8 probable transmembrane helices predicted for ETEC1093 by TMHMM2.0 at aa 7-29, 44-66, 75-97, 112-131, 151-168, 191-213, 220-242 and 257-274
316401004494	putative transposase OrfB; Reviewed; Region: PHA02517
316401004495	HTH-like domain; Region: HTH_21; pfam13276
316401004496	Integrase core domain; Region: rve; pfam00665
316401004497	Integrase core domain; Region: rve_2; pfam13333
316401004498	Transposase; Region: HTH_Tnp_1; cl17663
316401004499	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
316401004500	Acyl transferase domain; Region: Acyl_transf_1; cl08282
316401004501	8 probable transmembrane helices predicted for ETEC1097 by TMHMM2.0 at aa 17-39, 44-66, 87-109, 119-141, 162-181, 201-223, 256-278 and 288-310
316401004502	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
316401004503	putative ligand binding site [chemical binding]; other site
316401004504	NAD binding site [chemical binding]; other site
316401004505	dimerization interface [polypeptide binding]; other site
316401004506	catalytic site [active]
316401004507	PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3.
316401004508	putative hydrolase; Validated; Region: PRK09248
316401004509	Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437
316401004510	active site
316401004511	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
316401004512	Protein of unknown function (DUF1097); Region: DUF1097; pfam06496
316401004513	Signal peptide predicted for ETEC1101 by SignalP 2.0 HMM (Signal peptide probability 0.689) with cleavage site probability 0.524 between residues 41 and 42
316401004514	5 probable transmembrane helices predicted for ETEC1101 by TMHMM2.0 at aa 20-42, 49-68, 72-94, 99-118 and 123-145
316401004515	curli production assembly/transport protein CsgG; Provisional; Region: PRK15184
316401004516	Signal peptide predicted for ETEC1102 by SignalP 2.0 HMM (Signal peptide probability 0.978) with cleavage site probability 0.508 between residues 25 and 26
316401004517	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401004518	curli assembly protein CsgF; Provisional; Region: PRK10050
316401004519	1 probable transmembrane helix predicted for ETEC1103 by TMHMM2.0 at aa 7-26
316401004520	Signal peptide predicted for ETEC1103 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.997 between residues 19 and 20
316401004521	curli assembly protein CsgE; Provisional; Region: PRK10386
316401004522	PS00626 Regulator of chromosome condensation (RCC1) signature 2.
316401004523	Signal peptide predicted for ETEC1104 by SignalP 2.0 HMM (Signal peptide probability 0.877) with cleavage site probability 0.873 between residues 22 and 23
316401004524	DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100
316401004525	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
316401004526	DNA binding residues [nucleotide binding]
316401004527	dimerization interface [polypeptide binding]; other site
316401004528	PS00622 Bacterial regulatory proteins, luxR family signature.
316401004529	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
316401004530	Curlin associated repeat; Region: Curlin_rpt; pfam07012
316401004531	Curlin associated repeat; Region: Curlin_rpt; pfam07012
316401004532	Signal peptide predicted for ETEC1106 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.958 between residues 21 and 22
316401004533	major curlin subunit; Provisional; Region: csgA; PRK10051
316401004534	Curlin associated repeat; Region: Curlin_rpt; pfam07012
316401004535	Curlin associated repeat; Region: Curlin_rpt; pfam07012
316401004536	Signal peptide predicted for ETEC1107 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 20 and 21
316401004537	Fimbrial protein; Region: Fimbrial; cl01416
316401004538	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
316401004539	putative ADP-ribose binding site [chemical binding]; other site
316401004540	putative active site [active]
316401004541	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
316401004542	PLD-like domain; Region: PLDc_2; pfam13091
316401004543	putative active site [active]
316401004544	catalytic site [active]
316401004545	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
316401004546	PLD-like domain; Region: PLDc_2; pfam13091
316401004547	putative active site [active]
316401004548	catalytic site [active]
316401004549	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
316401004550	Acyltransferase family; Region: Acyl_transf_3; pfam01757
316401004551	10 probable transmembrane helices predicted for ETEC1112 by TMHMM2.0 at aa 17-39, 54-76, 88-110, 136-158, 179-198, 213-235, 242-261, 276-295, 308-330 and 334-356
316401004552	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
316401004553	Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349
316401004554	Signal peptide predicted for ETEC1113 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 22 and 23
316401004555	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
316401004556	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
316401004557	Ligand binding site; other site
316401004558	DXD motif; other site
316401004559	6 probable transmembrane helices predicted for ETEC1114 by TMHMM2.0 at aa 139-156, 194-216, 512-534, 568-590, 603-625 and 680-702
316401004560	PS00213 Lipocalin signature.
316401004561	lipoprotein; Provisional; Region: PRK10175
316401004562	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401004563	secY/secA suppressor protein; Provisional; Region: PRK11467
316401004564	drug efflux system protein MdtG; Provisional; Region: PRK09874
316401004565	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401004566	putative substrate translocation pore; other site
316401004567	10 probable transmembrane helices predicted for ETEC1117 by TMHMM2.0 at aa 17-39, 54-76, 110-132, 142-164, 171-193, 224-246, 253-275, 290-308, 315-337 and 374-396
316401004568	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
316401004569	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
316401004570	putative acyl-acceptor binding pocket; other site
316401004571	1 probable transmembrane helix predicted for ETEC1118 by TMHMM2.0 at aa 16-38
316401004572	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
316401004573	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
316401004574	active site residue [active]
316401004575	PS00017 ATP/GTP-binding site motif A (P-loop).
316401004576	hypothetical protein; Provisional; Region: PRK03757
316401004577	PS00387 Inorganic pyrophosphatase signature.
316401004578	Signal peptide predicted for ETEC1120 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 22 and 23
316401004579	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
316401004580	4 probable transmembrane helices predicted for ETEC1121 by TMHMM2.0 at aa 21-43, 58-76, 96-118 and 151-173
316401004581	IS1 transposase; Region: DDE_Tnp_IS1; pfam03400
316401004582	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
316401004583	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
316401004584	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
316401004585	PS00017 ATP/GTP-binding site motif A (P-loop).
316401004586	Protein of unknown function (DUF2770); Region: DUF2770; pfam10968
316401004587	1 probable transmembrane helix predicted for ETEC1123 by TMHMM2.0 at aa 21-43
316401004588	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
316401004589	hydroxyglutarate oxidase; Provisional; Region: PRK11728
316401004590	biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301
316401004591	DNA damage-inducible protein I; Provisional; Region: PRK10597
316401004592	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
316401004593	active site
316401004594	substrate binding pocket [chemical binding]; other site
316401004595	dimer interface [polypeptide binding]; other site
316401004596	PS00483 Dihydroorotase signature 2.
316401004597	PS00482 Dihydroorotase signature 1.
316401004598	lipoprotein; Provisional; Region: PRK10598
316401004599	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401004600	Signal peptide predicted for ETEC1128 by SignalP 2.0 HMM (Signal peptide probability 0.982) with cleavage site probability 0.519 between residues 18 and 19
316401004601	glutaredoxin 2; Provisional; Region: PRK10387
316401004602	GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037
316401004603	C-terminal domain interface [polypeptide binding]; other site
316401004604	GSH binding site (G-site) [chemical binding]; other site
316401004605	catalytic residues [active]
316401004606	putative dimer interface [polypeptide binding]; other site
316401004607	C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199
316401004608	N-terminal domain interface [polypeptide binding]; other site
316401004609	PS00195 Glutaredoxin active site.
316401004610	multidrug resistance protein MdtH; Provisional; Region: PRK11646
316401004611	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401004612	putative substrate translocation pore; other site
316401004613	10 probable transmembrane helices predicted for ETEC1130 by TMHMM2.0 at aa 13-35, 99-116, 136-158, 163-185, 210-232, 247-264, 277-296, 300-322, 335-357 and 367-386
316401004614	ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809
316401004615	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
316401004616	hypothetical protein; Provisional; Region: PRK11239
316401004617	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132
316401004618	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
316401004619	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
316401004620	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
316401004621	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
316401004622	MviN-like protein; Region: MVIN; pfam03023
316401004623	Signal peptide predicted for ETEC1134 by SignalP 2.0 HMM (Signal peptide probability 0.987) with cleavage site probability 0.688 between residues 23 and 24
316401004624	13 probable transmembrane helices predicted for ETEC1134 by TMHMM2.0 at aa 26-45, 82-104, 133-152, 159-181, 186-203, 237-259, 274-296, 316-338, 353-375, 382-404, 408-427, 444-466 and 481-503
316401004625	flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459
316401004626	anti-sigma28 factor FlgM; Provisional; Region: PRK10810
316401004627	Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261
316401004628	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
316401004629	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
316401004630	Signal peptide predicted for ETEC1137 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.969 between residues 21 and 22
316401004631	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
316401004632	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
316401004633	PS00588 Flagella basal body rod proteins signature.
316401004634	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
316401004635	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
316401004636	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
316401004637	PS00588 Flagella basal body rod proteins signature.
316401004638	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
316401004639	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
316401004640	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
316401004641	Signal peptide predicted for ETEC1140 by SignalP 2.0 HMM (Signal peptide probability 0.698) with cleavage site probability 0.674 between residues 28 and 29
316401004642	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
316401004643	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
316401004644	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
316401004645	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
316401004646	PS00588 Flagella basal body rod proteins signature.
316401004647	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787
316401004648	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
316401004649	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
316401004650	PS00588 Flagella basal body rod proteins signature.
316401004651	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
316401004652	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
316401004653	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
316401004654	PS00588 Flagella basal body rod proteins signature.
316401004655	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
316401004656	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
316401004657	Signal peptide predicted for ETEC1144 by SignalP 2.0 HMM (Signal peptide probability 0.972) with cleavage site probability 0.758 between residues 33 and 34
316401004658	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401004659	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
316401004660	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
316401004661	Signal peptide predicted for ETEC1145 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.968 between residues 19 and 20
316401004662	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
316401004663	Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951
316401004664	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
316401004665	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147
316401004666	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
316401004667	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
316401004668	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027
316401004669	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
316401004670	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
316401004671	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
316401004672	homodimer interface [polypeptide binding]; other site
316401004673	oligonucleotide binding site [chemical binding]; other site
316401004674	Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111
316401004675	Protein of unknown function (DUF2655); Region: DUF2655; pfam10848
316401004676	PS00017 ATP/GTP-binding site motif A (P-loop).
316401004677	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
316401004678	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
316401004679	RNA binding surface [nucleotide binding]; other site
316401004680	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
316401004681	active site
316401004682	PS01129 Rlu family of pseudouridine synthase signature.
316401004683	Maf-like protein; Region: Maf; pfam02545
316401004684	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
316401004685	active site
316401004686	dimer interface [polypeptide binding]; other site
316401004687	hypothetical protein; Provisional; Region: PRK11193
316401004688	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
316401004689	putative phosphate acyltransferase; Provisional; Region: PRK05331
316401004690	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
316401004691	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
316401004692	dimer interface [polypeptide binding]; other site
316401004693	active site
316401004694	CoA binding pocket [chemical binding]; other site
316401004695	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
316401004696	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
316401004697	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
316401004698	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
316401004699	NAD(P) binding site [chemical binding]; other site
316401004700	homotetramer interface [polypeptide binding]; other site
316401004701	homodimer interface [polypeptide binding]; other site
316401004702	active site
316401004703	PS00061 Short-chain dehydrogenases/reductases family signature.
316401004704	acyl carrier protein; Provisional; Region: acpP; PRK00982
316401004705	PS00012 Phosphopantetheine attachment site.
316401004706	PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature.
316401004707	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
316401004708	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
316401004709	dimer interface [polypeptide binding]; other site
316401004710	active site
316401004711	Signal peptide predicted for ETEC1160 by SignalP 2.0 HMM (Signal peptide probability 0.875) with cleavage site probability 0.786 between residues 20 and 21
316401004712	PS00606 Beta-ketoacyl synthases active site.
316401004713	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
316401004714	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
316401004715	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316401004716	catalytic residue [active]
316401004717	PS00770 Aminotransferases class-IV signature.
316401004718	conserved hypothetical protein, YceG family; Region: TIGR00247
316401004719	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
316401004720	dimerization interface [polypeptide binding]; other site
316401004721	Signal peptide predicted for ETEC1162 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.462 between residues 20 and 21
316401004722	1 probable transmembrane helix predicted for ETEC1162 by TMHMM2.0 at aa 5-24
316401004723	thymidylate kinase; Validated; Region: tmk; PRK00698
316401004724	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
316401004725	TMP-binding site; other site
316401004726	ATP-binding site [chemical binding]; other site
316401004727	PS00017 ATP/GTP-binding site motif A (P-loop).
316401004728	PS01331 Thymidylate kinase signature.
316401004729	DNA polymerase III subunit delta'; Validated; Region: PRK07993
316401004730	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
316401004731	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
316401004732	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
316401004733	active site
316401004734	PS01137 Uncharacterized protein family UPF0006 signature 1.
316401004735	PS01091 Uncharacterized protein family UPF0006 signature 3.
316401004736	PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089
316401004737	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
316401004738	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
316401004739	active site turn [active]
316401004740	phosphorylation site [posttranslational modification]
316401004741	10 probable transmembrane helices predicted for ETEC1166 by TMHMM2.0 at aa 21-43, 53-72, 79-101, 116-133, 154-176, 191-213, 250-272, 282-304, 309-331 and 354-376
316401004742	PS01035 PTS EIIB domains cysteine phosphorylation site signature.
316401004743	ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003
316401004744	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
316401004745	N-terminal plug; other site
316401004746	ligand-binding site [chemical binding]; other site
316401004747	PS01156 TonB-dependent receptor proteins signature 2.
316401004748	PS00430 TonB-dependent receptor proteins signature 1.
316401004749	Signal peptide predicted for ETEC1167 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 36 and 37
316401004750	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
316401004751	nucleotide binding site/active site [active]
316401004752	HIT family signature motif; other site
316401004753	catalytic residue [active]
316401004754	PS00892 HIT family signature.
316401004755	Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417
316401004756	Signal peptide predicted for ETEC1170 by SignalP 2.0 HMM (Signal peptide probability 0.948) with cleavage site probability 0.483 between residues 23 and 24
316401004757	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401004758	thiamine kinase; Region: ycfN_thiK; TIGR02721
316401004759	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
316401004760	active site
316401004761	substrate binding site [chemical binding]; other site
316401004762	ATP binding site [chemical binding]; other site
316401004763	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
316401004764	beta-hexosaminidase; Provisional; Region: PRK05337
316401004765	PS00775 Glycosyl hydrolases family 3 active site.
316401004766	hypothetical protein; Provisional; Region: PRK04940
316401004767	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
316401004768	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
316401004769	hypothetical protein; Provisional; Region: PRK11280
316401004770	Signal peptide predicted for ETEC1175 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.652 between residues 23 and 24
316401004771	1 probable transmembrane helix predicted for ETEC1175 by TMHMM2.0 at aa 5-27
316401004772	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
316401004773	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
316401004774	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
316401004775	Signal peptide predicted for ETEC1177 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.992 between residues 22 and 23
316401004776	L,D-transpeptidase; Provisional; Region: PRK10260
316401004777	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
316401004778	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
316401004779	Signal peptide predicted for ETEC1178 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.943 between residues 28 and 29
316401004780	1 probable transmembrane helix predicted for ETEC1178 by TMHMM2.0 at aa 7-26
316401004781	transcription-repair coupling factor; Provisional; Region: PRK10689
316401004782	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
316401004783	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
316401004784	ATP binding site [chemical binding]; other site
316401004785	putative Mg++ binding site [ion binding]; other site
316401004786	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
316401004787	nucleotide binding region [chemical binding]; other site
316401004788	ATP-binding site [chemical binding]; other site
316401004789	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
316401004790	PS00017 ATP/GTP-binding site motif A (P-loop).
316401004791	Predicted membrane protein [Function unknown]; Region: COG4763
316401004792	Acyltransferase family; Region: Acyl_transf_3; pfam01757
316401004793	8 probable transmembrane helices predicted for ETEC1180 by TMHMM2.0 at aa 13-32, 47-69, 90-112, 134-156, 163-185, 229-251, 272-294 and 309-331
316401004794	outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814
316401004795	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
316401004796	FtsX-like permease family; Region: FtsX; pfam02687
316401004797	4 probable transmembrane helices predicted for ETEC1181 by TMHMM2.0 at aa 25-47, 266-288, 318-340 and 360-382
316401004798	lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629
316401004799	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
316401004800	Walker A/P-loop; other site
316401004801	ATP binding site [chemical binding]; other site
316401004802	Q-loop/lid; other site
316401004803	ABC transporter signature motif; other site
316401004804	Walker B; other site
316401004805	D-loop; other site
316401004806	H-loop/switch region; other site
316401004807	PS00017 ATP/GTP-binding site motif A (P-loop).
316401004808	PS00211 ABC transporters family signature.
316401004809	outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146
316401004810	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
316401004811	FtsX-like permease family; Region: FtsX; pfam02687
316401004812	4 probable transmembrane helices predicted for ETEC1183 by TMHMM2.0 at aa 21-43, 270-292, 319-341 and 375-397
316401004813	PS00027 'Homeobox' domain signature.
316401004814	fructokinase; Reviewed; Region: PRK09557
316401004815	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
316401004816	nucleotide binding site [chemical binding]; other site
316401004817	PS01125 ROK family signature.
316401004818	PS00017 ATP/GTP-binding site motif A (P-loop).
316401004819	PS00030 Eukaryotic putative RNA-binding region RNP-1 signature.
316401004820	NAD-dependent deacetylase; Provisional; Region: PRK00481
316401004821	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
316401004822	NAD+ binding site [chemical binding]; other site
316401004823	substrate binding site [chemical binding]; other site
316401004824	Zn binding site [ion binding]; other site
316401004825	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
316401004826	4 probable transmembrane helices predicted for ETEC1186 by TMHMM2.0 at aa 5-27, 183-202, 207-229 and 239-258
316401004827	Signal peptide predicted for ETEC1186 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.813 between residues 20 and 21
316401004828	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
316401004829	2 probable transmembrane helices predicted for ETEC1187 by TMHMM2.0 at aa 7-29 and 120-142
316401004830	spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501
316401004831	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
316401004832	Signal peptide predicted for ETEC1188 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 23 and 24
316401004833	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
316401004834	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401004835	dimer interface [polypeptide binding]; other site
316401004836	conserved gate region; other site
316401004837	putative PBP binding loops; other site
316401004838	ABC-ATPase subunit interface; other site
316401004839	6 probable transmembrane helices predicted for ETEC1189 by TMHMM2.0 at aa 5-27, 64-86, 99-121, 126-148, 176-195 and 230-252
316401004840	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
316401004841	Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003
316401004842	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
316401004843	Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome.  They belong to the superfamily...; Region: INT_Lambda_C; cd00800
316401004844	dimer interface [polypeptide binding]; other site
316401004845	active site
316401004846	Int/Topo IB signature motif; other site
316401004847	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
316401004848	active site
316401004849	catalytic site [active]
316401004850	substrate binding site [chemical binding]; other site
316401004851	Protein of unknown function (DUF1482); Region: DUF1482; pfam07358
316401004852	DicB protein; Region: DicB; pfam05358
316401004855	Protein of unknown function (DUF1391); Region: DUF1391; pfam07151
316401004856	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
316401004857	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
316401004858	Catalytic site [active]
316401004859	Protein of unknown function (DUF1019); Region: DUF1019; pfam06254
316401004860	primosomal protein DnaI; Provisional; Region: PRK02854
316401004861	Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163
316401004863	Protein of unknown function (DUF968); Region: DUF968; pfam06147
316401004864	PS00190 Cytochrome c family heme-binding site signature.
316401004865	Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570
316401004866	Protein of unknown function (DUF1133); Region: DUF1133; pfam06576
316401004867	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316401004868	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
316401004869	DNA methylase; Region: N6_N4_Mtase; pfam01555
316401004870	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
316401004871	PS00092 N-6 Adenine-specific DNA methylases signature.
316401004872	Protein of unknown function (DUF3927); Region: DUF3927; pfam13064
316401004873	Signal peptide predicted for ETEC1212 by SignalP 2.0 HMM (Signal peptide probability 0.926) with cleavage site probability 0.519 between residues 30 and 31
316401004874	2 probable transmembrane helices predicted for ETEC1212 by TMHMM2.0 at aa 5-22 and 27-46
316401004875	Signal peptide predicted for ETEC1213 by SignalP 2.0 HMM (Signal peptide probability 0.700) with cleavage site probability 0.454 between residues 36 and 37
316401004876	2 probable transmembrane helices predicted for ETEC1213 by TMHMM2.0 at aa 20-42 and 54-76
316401004877	Protein of unknown function (DUF754); Region: DUF754; pfam05449
316401004878	3 probable transmembrane helices predicted for ETEC1214 by TMHMM2.0 at aa 10-29, 42-59 and 64-82
316401004879	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
316401004880	1 probable transmembrane helix predicted for ETEC1216 by TMHMM2.0 at aa 34-56
316401004881	Signal peptide predicted for ETEC1219 by SignalP 2.0 HMM (Signal peptide probability 0.861) with cleavage site probability 0.822 between residues 18 and 19
316401004882	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401004883	Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471
316401004884	Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525
316401004885	Bacteriophage capsid protein [General function prediction only]; Region: COG5511
316401004886	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
316401004887	Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022
316401004888	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
316401004889	tandem repeat interface [polypeptide binding]; other site
316401004890	oligomer interface [polypeptide binding]; other site
316401004891	active site residues [active]
316401004892	Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924
316401004893	Transposase; Region: HTH_Tnp_1; pfam01527
316401004894	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
316401004895	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
316401004896	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
316401004897	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
316401004898	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
316401004899	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
316401004900	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
316401004901	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
316401004902	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
316401004903	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
316401004904	DNA packaging protein FI; Region: Packaging_FI; pfam14000
316401004905	Phage Head-Tail Attachment; Region: Phage_attach; pfam05354
316401004906	Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763
316401004907	Phage minor tail protein U; Region: Phage_tail_U; pfam06141
316401004908	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
316401004909	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
316401004910	Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894
316401004911	Minor tail protein T; Region: Phage_tail_T; pfam06223
316401004912	Phage-related minor tail protein [Function unknown]; Region: COG5281
316401004913	Prophage tail length tape measure protein; Region: TMP_2; pfam06791
316401004914	Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718
316401004915	Phage-related protein [Function unknown]; Region: gp18; COG4672
316401004916	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073
316401004917	MPN+ (JAMM) motif; other site
316401004918	Zinc-binding site [ion binding]; other site
316401004919	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
316401004920	NlpC/P60 family; Region: NLPC_P60; cl17555
316401004921	Phage-related protein, tail component [Function unknown]; Region: COG4723
316401004922	2 probable transmembrane helices predicted for ETEC1240 by TMHMM2.0 at aa 102-124 and 129-151
316401004923	Phage-related protein, tail component [Function unknown]; Region: COG4733
316401004924	Putative phage tail protein; Region: Phage-tail_3; pfam13550
316401004925	Domain of unknown function (DUF1983); Region: DUF1983; pfam09327
316401004926	Fibronectin type III protein; Region: DUF3672; pfam12421
316401004927	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
316401004928	Signal peptide predicted for ETEC1242 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 24 and 25
316401004929	PS00694 Enterobacterial virulence outer membrane protein signature 1.
316401004930	PS00695 Enterobacterial virulence outer membrane protein signature 2.
316401004931	Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400
316401004932	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
316401004933	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
316401004934	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
316401004935	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
316401004936	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
316401004937	Phage-related tail fibre protein [General function prediction only]; Region: COG5301
316401004938	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
316401004939	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
316401004940	catalytic residues [active]
316401004941	catalytic nucleophile [active]
316401004942	PS00397 Site-specific recombinases active site.
316401004943	Methyltransferase domain; Region: Methyltransf_12; pfam08242
316401004944	S-adenosylmethionine binding site [chemical binding]; other site
316401004945	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
316401004946	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401004947	dimer interface [polypeptide binding]; other site
316401004948	conserved gate region; other site
316401004949	putative PBP binding loops; other site
316401004950	ABC-ATPase subunit interface; other site
316401004951	6 probable transmembrane helices predicted for ETEC1249 by TMHMM2.0 at aa 5-27, 59-81, 88-110, 141-163, 184-206 and 240-262
316401004952	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
316401004953	putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452
316401004954	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316401004955	Walker A/P-loop; other site
316401004956	ATP binding site [chemical binding]; other site
316401004957	Q-loop/lid; other site
316401004958	ABC transporter signature motif; other site
316401004959	Walker B; other site
316401004960	D-loop; other site
316401004961	H-loop/switch region; other site
316401004962	TOBE domain; Region: TOBE_2; pfam08402
316401004963	PS00211 ABC transporters family signature.
316401004964	PS00017 ATP/GTP-binding site motif A (P-loop).
316401004965	Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195
316401004966	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
316401004967	metal binding site [ion binding]; metal-binding site
316401004968	dimer interface [polypeptide binding]; other site
316401004969	PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1.
316401004970	PS00759 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2.
316401004971	Uncharacterized conserved protein [Function unknown]; Region: COG2850
316401004972	Cupin-like domain; Region: Cupin_8; pfam13621
316401004973	sensor protein PhoQ; Provisional; Region: PRK10815
316401004974	PhoQ Sensor; Region: PhoQ_Sensor; pfam08918
316401004975	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
316401004976	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
316401004977	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316401004978	ATP binding site [chemical binding]; other site
316401004979	Mg2+ binding site [ion binding]; other site
316401004980	G-X-G motif; other site
316401004981	1 probable transmembrane helix predicted for ETEC1253 by TMHMM2.0 at aa 110-132
316401004982	DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816
316401004983	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316401004984	active site
316401004985	phosphorylation site [posttranslational modification]
316401004986	intermolecular recognition site; other site
316401004987	dimerization interface [polypeptide binding]; other site
316401004988	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
316401004989	DNA binding site [nucleotide binding]
316401004990	adenylosuccinate lyase; Provisional; Region: PRK09285
316401004991	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
316401004992	tetramer interface [polypeptide binding]; other site
316401004993	active site
316401004994	PS00163 Fumarate lyases signature.
316401004995	putative lysogenization regulator; Reviewed; Region: PRK00218
316401004996	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
316401004997	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420
316401004998	PS00070 Aldehyde dehydrogenases cysteine active site.
316401004999	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
316401005000	nudix motif; other site
316401005001	PS00893 mutT domain signature.
316401005002	23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394
316401005003	Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566
316401005004	probable active site [active]
316401005005	PS01149 Rsu family of pseudouridine synthase signature.
316401005006	isocitrate dehydrogenase; Validated; Region: PRK07362
316401005007	isocitrate dehydrogenase; Reviewed; Region: PRK07006
316401005008	PS00470 Isocitrate and isopropylmalate dehydrogenases signature.
316401005009	anti-adapter protein IraM; Provisional; Region: PRK09919
316401005010	Protein of unknown function (DUF1398); Region: DUF1398; pfam07166
316401005011	transcriptional regulator MirA; Provisional; Region: PRK15043
316401005012	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
316401005013	DNA binding residues [nucleotide binding]
316401005014	PS00552 Bacterial regulatory proteins, merR family signature.
316401005016	Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798
316401005017	Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798
316401005018	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
316401005019	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
316401005020	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
316401005021	Signal peptide predicted for ETEC1269 by SignalP 2.0 HMM (Signal peptide probability 0.671) with cleavage site probability 0.577 between residues 22 and 23
316401005022	2 probable transmembrane helices predicted for ETEC1269 by TMHMM2.0 at aa 5-27 and 222-239
316401005023	2 probable transmembrane helices predicted for ETEC1270 by TMHMM2.0 at aa 9-31 and 36-58
316401005026	Signal peptide predicted for ETEC1274 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 19 and 20
316401005027	Signal peptide predicted for ETEC1275 by SignalP 2.0 HMM (Signal peptide probability 0.909) with cleavage site probability 0.675 between residues 24 and 25
316401005028	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
316401005029	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
316401005030	cell division inhibitor MinD; Provisional; Region: PRK10818
316401005031	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
316401005032	Switch I; other site
316401005033	Switch II; other site
316401005034	PS00017 ATP/GTP-binding site motif A (P-loop).
316401005035	septum formation inhibitor; Reviewed; Region: minC; PRK03511
316401005036	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
316401005037	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
316401005038	Fels-1 Prophage Protein-like; Region: Fels1; pfam05666
316401005039	Fels-1 Prophage Protein-like; Region: Fels1; pfam05666
316401005040	Signal peptide predicted for ETEC1281 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.515 between residues 24 and 25
316401005041	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
316401005042	Signal peptide predicted for ETEC1282 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.827 between residues 22 and 23
316401005043	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100
316401005044	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
316401005045	hypothetical protein; Provisional; Region: PRK10691
316401005046	hypothetical protein; Provisional; Region: PRK05170
316401005047	hemolysin E; Provisional; Region: hlyE; PRK11376
316401005048	1 probable transmembrane helix predicted for ETEC1286 by TMHMM2.0 at aa 181-203
316401005049	PS00136 Serine proteases, subtilase family, aspartic acid active site.
316401005050	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
316401005051	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
316401005052	Catalytic site [active]
316401005053	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
316401005054	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
316401005055	active site
316401005056	DNA binding site [nucleotide binding]
316401005057	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
316401005058	disulfide bond formation protein B; Provisional; Region: PRK01749
316401005059	4 probable transmembrane helices predicted for ETEC1289 by TMHMM2.0 at aa 13-32, 42-64, 71-89 and 145-162
316401005060	Signal peptide predicted for ETEC1289 by SignalP 2.0 HMM (Signal peptide probability 0.885) with cleavage site probability 0.867 between residues 24 and 25
316401005061	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
316401005062	transmembrane helices; other site
316401005063	12 probable transmembrane helices predicted for ETEC1290 by TMHMM2.0 at aa 26-48, 61-80, 95-117, 122-144, 148-165, 197-219, 239-261, 299-331, 346-368, 389-411, 453-472 and 479-501
316401005064	fatty acid metabolism regulator; Provisional; Region: PRK04984
316401005065	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
316401005066	DNA-binding site [nucleotide binding]; DNA binding site
316401005067	FadR C-terminal domain; Region: FadR_C; pfam07840
316401005068	PS00043 Bacterial regulatory proteins, gntR family signature.
316401005069	SpoVR family protein; Provisional; Region: PRK11767
316401005070	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
316401005071	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
316401005072	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
316401005073	alanine racemase; Reviewed; Region: dadX; PRK03646
316401005074	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
316401005075	active site
316401005076	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
316401005077	substrate binding site [chemical binding]; other site
316401005078	catalytic residues [active]
316401005079	dimer interface [polypeptide binding]; other site
316401005080	PS00395 Alanine racemase pyridoxal-phosphate attachment site.
316401005081	NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263
316401005082	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
316401005083	TrkA-C domain; Region: TrkA_C; pfam02080
316401005084	Transporter associated domain; Region: CorC_HlyC; smart01091
316401005085	11 probable transmembrane helices predicted for ETEC1295 by TMHMM2.0 at aa 4-26, 31-53, 57-74, 87-109, 119-141, 195-217, 232-254, 267-289, 299-321, 334-356 and 361-383
316401005086	Signal peptide predicted for ETEC1295 by SignalP 2.0 HMM (Signal peptide probability 0.690) with cleavage site probability 0.422 between residues 30 and 31
316401005087	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
316401005088	dimer interface [polypeptide binding]; other site
316401005089	catalytic triad [active]
316401005090	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
316401005091	Flagellar regulator YcgR; Region: YcgR; pfam07317
316401005092	PilZ domain; Region: PilZ; pfam07238
316401005093	hypothetical protein; Provisional; Region: PRK10457
316401005094	3 probable transmembrane helices predicted for ETEC1299 by TMHMM2.0 at aa 4-22, 27-49 and 59-81
316401005095	trehalase; Provisional; Region: treA; PRK13271
316401005096	Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626
316401005097	PS00928 Trehalase signature 2.
316401005098	PS00927 Trehalase signature 1.
316401005099	Signal peptide predicted for ETEC1301 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 30 and 31
316401005100	dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377
316401005101	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412
316401005102	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
316401005103	dimerization domain swap beta strand [polypeptide binding]; other site
316401005104	regulatory protein interface [polypeptide binding]; other site
316401005105	active site
316401005106	regulatory phosphorylation site [posttranslational modification]; other site
316401005107	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
316401005108	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
316401005109	dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005
316401005110	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468
316401005111	Dak1 domain; Region: Dak1; pfam02733
316401005112	DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388
316401005113	PAS domain; Region: PAS; smart00091
316401005114	putative active site [active]
316401005115	heme pocket [chemical binding]; other site
316401005116	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316401005117	Walker A motif; other site
316401005118	ATP binding site [chemical binding]; other site
316401005119	Walker B motif; other site
316401005120	arginine finger; other site
316401005121	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
316401005122	PS00675 Sigma-54 interaction domain ATP-binding region A signature.
316401005123	PS00676 Sigma-54 interaction domain ATP-binding region B signature.
316401005124	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343
316401005125	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
316401005126	Autotransporter beta-domain; Region: Autotransporter; pfam03797
316401005127	GTP-binding protein YchF; Reviewed; Region: PRK09601
316401005128	YchF GTPase; Region: YchF; cd01900
316401005129	G1 box; other site
316401005130	GTP/Mg2+ binding site [chemical binding]; other site
316401005131	Switch I region; other site
316401005132	G2 box; other site
316401005133	Switch II region; other site
316401005134	G3 box; other site
316401005135	G4 box; other site
316401005136	G5 box; other site
316401005137	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
316401005138	PS00017 ATP/GTP-binding site motif A (P-loop).
316401005139	PS00443 Glutamine amidotransferases class-II active site.
316401005140	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
316401005141	putative active site [active]
316401005142	catalytic residue [active]
316401005143	PS00217 Sugar transport proteins signature 2.
316401005144	PS01196 Peptidyl-tRNA hydrolase signature 2.
316401005145	PS01195 Peptidyl-tRNA hydrolase signature 1.
316401005146	hypothetical protein; Provisional; Region: PRK10692
316401005147	Signal peptide predicted for ETEC1309 by SignalP 2.0 HMM (Signal peptide probability 0.896) with cleavage site probability 0.381 between residues 24 and 25
316401005148	2 probable transmembrane helices predicted for ETEC1309 by TMHMM2.0 at aa 7-29 and 42-64
316401005149	putative transporter; Provisional; Region: PRK11660
316401005150	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
316401005151	Sulfate transporter family; Region: Sulfate_transp; pfam00916
316401005152	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
316401005153	11 probable transmembrane helices predicted for ETEC1310 by TMHMM2.0 at aa 34-56, 61-83, 103-125, 130-152, 177-199, 212-234, 278-300, 313-335, 345-367, 369-388 and 408-439
316401005154	PS01130 Sulfate transporters signature.
316401005155	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
316401005156	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
316401005157	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
316401005158	active site
316401005159	PS00103 Purine/pyrimidine phosphoribosyl transferases signature.
316401005160	PS00114 Phosphoribosyl pyrophosphate synthetase signature.
316401005161	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
316401005162	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
316401005163	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
316401005164	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
316401005165	outer membrane lipoprotein LolB; Region: lolB; TIGR00548
316401005166	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
316401005167	Signal peptide predicted for ETEC1313 by SignalP 2.0 HMM (Signal peptide probability 0.615) with cleavage site probability 0.448 between residues 23 and 24
316401005168	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
316401005169	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
316401005170	tRNA; other site
316401005171	putative tRNA binding site [nucleotide binding]; other site
316401005172	putative NADP binding site [chemical binding]; other site
316401005173	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
316401005174	PS00747 Glutamyl-tRNA reductase signature.
316401005175	peptide chain release factor 1; Validated; Region: prfA; PRK00591
316401005176	This domain is found in peptide chain release factors; Region: PCRF; smart00937
316401005177	RF-1 domain; Region: RF-1; pfam00472
316401005178	PS00745 Prokaryotic-type class I peptide chain release factors signature.
316401005179	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
316401005180	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316401005181	PS00092 N-6 Adenine-specific DNA methylases signature.
316401005182	hypothetical protein; Provisional; Region: PRK10278
316401005183	4 probable transmembrane helices predicted for ETEC1317 by TMHMM2.0 at aa 10-28, 40-59, 74-93 and 105-124
316401005184	hypothetical protein; Provisional; Region: PRK10941
316401005185	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
316401005186	PS00030 Eukaryotic putative RNA-binding region RNP-1 signature.
316401005187	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
316401005188	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
316401005189	Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940
316401005190	1 probable transmembrane helix predicted for ETEC1320 by TMHMM2.0 at aa 15-32
316401005191	Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940
316401005192	1 probable transmembrane helix predicted for ETEC1321 by TMHMM2.0 at aa 10-32
316401005193	calcium/sodium:proton antiporter; Provisional; Region: PRK10599
316401005194	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
316401005195	11 probable transmembrane helices predicted for ETEC1322 by TMHMM2.0 at aa 13-32, 36-58, 71-93, 108-127, 139-161, 166-188, 221-238, 258-280, 287-309, 319-341 and 346-365
316401005196	cation transport regulator; Reviewed; Region: chaB; PRK09582
316401005197	Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703
316401005198	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
316401005199	putative active site pocket [active]
316401005200	dimerization interface [polypeptide binding]; other site
316401005201	putative catalytic residue [active]
316401005202	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
316401005203	Protein of unknown function (DUF433); Region: DUF433; cl01030
316401005204	MULE transposase domain; Region: MULE; pfam10551
316401005205	PS01007 Transposases, Mutator family, signature.
316401005206	Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553
316401005207	putative invasin; Provisional; Region: PRK10177
316401005208	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
316401005209	transcriptional regulator NarL; Provisional; Region: PRK10651
316401005210	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316401005211	active site
316401005212	phosphorylation site [posttranslational modification]
316401005213	intermolecular recognition site; other site
316401005214	dimerization interface [polypeptide binding]; other site
316401005215	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
316401005216	DNA binding residues [nucleotide binding]
316401005217	dimerization interface [polypeptide binding]; other site
316401005218	PS00622 Bacterial regulatory proteins, luxR family signature.
316401005219	nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600
316401005220	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
316401005221	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
316401005222	dimerization interface [polypeptide binding]; other site
316401005223	Histidine kinase; Region: HisKA_3; pfam07730
316401005224	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316401005225	ATP binding site [chemical binding]; other site
316401005226	Mg2+ binding site [ion binding]; other site
316401005227	G-X-G motif; other site
316401005228	2 probable transmembrane helices predicted for ETEC1329 by TMHMM2.0 at aa 15-37 and 152-174
316401005229	Signal peptide predicted for ETEC1329 by SignalP 2.0 HMM (Signal peptide probability 0.988) with cleavage site probability 0.651 between residues 33 and 34
316401005230	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
316401005231	12 probable transmembrane helices predicted for ETEC1330 by TMHMM2.0 at aa 38-60, 75-97, 104-123, 133-155, 176-198, 213-235, 256-278, 288-307, 320-339, 354-376, 404-421 and 436-458
316401005232	respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580
316401005233	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
316401005234	[4Fe-4S] binding site [ion binding]; other site
316401005235	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
316401005236	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
316401005237	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
316401005238	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
316401005239	molybdopterin cofactor binding site; other site
316401005240	PS00551 Prokaryotic molybdopterin oxidoreductases signature 1.
316401005241	PS00490 Prokaryotic molybdopterin oxidoreductases signature 2.
316401005242	PS00037 Myb DNA-binding domain repeat signature 1.
316401005243	PS00932 Prokaryotic molybdopterin oxidoreductases signature 3.
316401005244	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
316401005245	4Fe-4S binding domain; Region: Fer4; cl02805
316401005246	PS00190 Cytochrome c family heme-binding site signature.
316401005247	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
316401005248	respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351
316401005249	5 probable transmembrane helices predicted for ETEC1334 by TMHMM2.0 at aa 4-26, 47-69, 89-108, 127-149 and 184-206
316401005250	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
316401005251	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
316401005252	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
316401005253	putative active site [active]
316401005254	putative substrate binding site [chemical binding]; other site
316401005255	putative cosubstrate binding site; other site
316401005256	catalytic site [active]
316401005257	SEC-C motif; Region: SEC-C; pfam02810
316401005258	hypothetical protein; Provisional; Region: PRK04233
316401005259	hypothetical protein; Provisional; Region: PRK10279
316401005260	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
316401005261	active site
316401005262	nucleophile elbow; other site
316401005263	PS01237 Uncharacterized protein family UPF0028 signature.
316401005264	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316401005265	active site
316401005266	response regulator of RpoS; Provisional; Region: PRK10693
316401005267	phosphorylation site [posttranslational modification]
316401005268	intermolecular recognition site; other site
316401005269	dimerization interface [polypeptide binding]; other site
316401005270	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
316401005271	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
316401005272	active site
316401005273	tetramer interface; other site
316401005274	PS00017 ATP/GTP-binding site motif A (P-loop).
316401005275	global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947
316401005276	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
316401005277	PS00017 ATP/GTP-binding site motif A (P-loop).
316401005278	thymidine kinase; Provisional; Region: PRK04296
316401005279	PS00603 Thymidine kinase cellular-type signature.
316401005280	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
316401005281	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
316401005282	putative catalytic cysteine [active]
316401005283	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
316401005284	putative active site [active]
316401005285	metal binding site [ion binding]; metal-binding site
316401005286	PS00060 Iron-containing alcohol dehydrogenases signature 2.
316401005287	PS00913 Iron-containing alcohol dehydrogenases signature 1.
316401005288	hypothetical protein; Provisional; Region: PRK11111
316401005289	6 probable transmembrane helices predicted for ETEC1344 by TMHMM2.0 at aa 10-32, 52-74, 78-100, 120-142, 146-168 and 189-211
316401005290	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
316401005291	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
316401005292	peptide binding site [polypeptide binding]; other site
316401005293	Signal peptide predicted for ETEC1345 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 26 and 27
316401005294	1 probable transmembrane helix predicted for ETEC1345 by TMHMM2.0 at aa 9-31
316401005295	PS01040 Bacterial extracellular solute-binding proteins, family 5 signature.
316401005296	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
316401005297	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401005298	dimer interface [polypeptide binding]; other site
316401005299	conserved gate region; other site
316401005300	putative PBP binding loops; other site
316401005301	ABC-ATPase subunit interface; other site
316401005302	6 probable transmembrane helices predicted for ETEC1346 by TMHMM2.0 at aa 13-30, 102-121, 134-156, 166-188, 228-250 and 278-300
316401005303	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
316401005304	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
316401005305	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
316401005306	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401005307	dimer interface [polypeptide binding]; other site
316401005308	conserved gate region; other site
316401005309	putative PBP binding loops; other site
316401005310	ABC-ATPase subunit interface; other site
316401005311	6 probable transmembrane helices predicted for ETEC1347 by TMHMM2.0 at aa 40-62, 103-125, 138-160, 164-183, 214-236 and 268-290
316401005312	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
316401005313	oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473
316401005314	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
316401005315	Walker A/P-loop; other site
316401005316	ATP binding site [chemical binding]; other site
316401005317	Q-loop/lid; other site
316401005318	ABC transporter signature motif; other site
316401005319	Walker B; other site
316401005320	D-loop; other site
316401005321	H-loop/switch region; other site
316401005322	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
316401005323	PS00017 ATP/GTP-binding site motif A (P-loop).
316401005324	PS00211 ABC transporters family signature.
316401005325	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
316401005326	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
316401005327	Walker A/P-loop; other site
316401005328	ATP binding site [chemical binding]; other site
316401005329	Q-loop/lid; other site
316401005330	ABC transporter signature motif; other site
316401005331	Walker B; other site
316401005332	D-loop; other site
316401005333	H-loop/switch region; other site
316401005334	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
316401005335	PS00017 ATP/GTP-binding site motif A (P-loop).
316401005336	PS00211 ABC transporters family signature.
316401005337	dsDNA-mimic protein; Reviewed; Region: PRK05094
316401005338	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
316401005339	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
316401005340	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
316401005341	putative active site [active]
316401005342	catalytic site [active]
316401005343	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158
316401005344	putative active site [active]
316401005345	catalytic site [active]
316401005346	2 probable transmembrane helices predicted for ETEC1351 by TMHMM2.0 at aa 10-29 and 36-58
316401005347	voltage-gated potassium channel; Provisional; Region: PRK10537
316401005348	Ion channel; Region: Ion_trans_2; pfam07885
316401005349	TrkA-N domain; Region: TrkA_N; pfam02254
316401005350	7 probable transmembrane helices predicted for ETEC1352 by TMHMM2.0 at aa 21-43, 58-80, 87-106, 110-127, 134-156, 171-193 and 200-222
316401005351	YciI-like protein; Reviewed; Region: PRK11370
316401005352	transport protein TonB; Provisional; Region: PRK10819
316401005353	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
316401005354	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
316401005355	intracellular septation protein A; Reviewed; Region: PRK00259
316401005356	5 probable transmembrane helices predicted for ETEC1356 by TMHMM2.0 at aa 22-44, 51-68, 78-95, 119-141 and 151-170
316401005357	hypothetical protein; Provisional; Region: PRK02868
316401005358	6 probable transmembrane helices predicted for ETEC1357 by TMHMM2.0 at aa 20-42, 87-109, 118-140, 144-166, 187-209 and 219-241
316401005359	Signal peptide predicted for ETEC1357 by SignalP 2.0 HMM (Signal peptide probability 0.851) with cleavage site probability 0.700 between residues 38 and 39
316401005360	outer membrane protein W; Provisional; Region: PRK10959
316401005361	Signal peptide predicted for ETEC1358 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 21 and 22
316401005362	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685
316401005363	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
316401005364	dimerization interface [polypeptide binding]; other site
316401005365	metal binding site [ion binding]; metal-binding site
316401005366	General stress protein [General function prediction only]; Region: GsiB; COG3729
316401005367	PS00017 ATP/GTP-binding site motif A (P-loop).
316401005368	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
316401005369	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
316401005370	substrate binding site [chemical binding]; other site
316401005371	active site
316401005372	catalytic residues [active]
316401005373	heterodimer interface [polypeptide binding]; other site
316401005374	PS00167 Tryptophan synthase alpha chain signature.
316401005375	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
316401005376	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
316401005377	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316401005378	catalytic residue [active]
316401005379	PS00168 Tryptophan synthase beta chain pyridoxal-phosphate attachment site.
316401005380	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
316401005381	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
316401005382	active site
316401005383	ribulose/triose binding site [chemical binding]; other site
316401005384	phosphate binding site [ion binding]; other site
316401005385	substrate (anthranilate) binding pocket [chemical binding]; other site
316401005386	product (indole) binding pocket [chemical binding]; other site
316401005387	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
316401005388	active site
316401005389	PS00614 Indole-3-glycerol phosphate synthase signature.
316401005390	bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522
316401005391	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
316401005392	glutamine binding [chemical binding]; other site
316401005393	catalytic triad [active]
316401005394	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
316401005395	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
316401005396	PS00442 Glutamine amidotransferases class-I active site.
316401005397	anthranilate synthase component I; Provisional; Region: PRK13564
316401005398	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
316401005399	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
316401005400	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
316401005401	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
316401005402	active site
316401005403	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
316401005404	hypothetical protein; Provisional; Region: PRK11630
316401005405	PS01147 SUA5/yciO/yrdC family signature.
316401005406	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
316401005407	Signal peptide predicted for ETEC1370 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 23 and 24
316401005408	5 probable transmembrane helices predicted for ETEC1370 by TMHMM2.0 at aa 249-266, 397-419, 429-448, 460-482 and 492-514
316401005409	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
316401005410	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
316401005411	RNA binding surface [nucleotide binding]; other site
316401005412	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
316401005413	probable active site [active]
316401005414	PS01149 Rsu family of pseudouridine synthase signature.
316401005415	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
316401005416	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
316401005417	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
316401005418	homodimer interface [polypeptide binding]; other site
316401005419	Walker A motif; other site
316401005420	ATP binding site [chemical binding]; other site
316401005421	hydroxycobalamin binding site [chemical binding]; other site
316401005422	Walker B motif; other site
316401005423	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
316401005424	Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340
316401005425	NADP binding site [chemical binding]; other site
316401005426	homodimer interface [polypeptide binding]; other site
316401005427	active site
316401005428	PS00061 Short-chain dehydrogenases/reductases family signature.
316401005429	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
316401005430	putative inner membrane peptidase; Provisional; Region: PRK11778
316401005431	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
316401005432	tandem repeat interface [polypeptide binding]; other site
316401005433	oligomer interface [polypeptide binding]; other site
316401005434	active site residues [active]
316401005435	2 probable transmembrane helices predicted for ETEC1374 by TMHMM2.0 at aa 10-32 and 190-207
316401005436	hypothetical protein; Provisional; Region: PRK11037
316401005437	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
316401005438	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
316401005439	active site
316401005440	interdomain interaction site; other site
316401005441	putative metal-binding site [ion binding]; other site
316401005442	nucleotide binding site [chemical binding]; other site
316401005443	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
316401005444	domain I; other site
316401005445	DNA binding groove [nucleotide binding]
316401005446	phosphate binding site [ion binding]; other site
316401005447	domain II; other site
316401005448	domain III; other site
316401005449	nucleotide binding site [chemical binding]; other site
316401005450	catalytic site [active]
316401005451	domain IV; other site
316401005452	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
316401005453	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
316401005454	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
316401005455	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
316401005456	PS00396 Prokaryotic DNA topoisomerase I active site.
316401005457	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
316401005458	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401005459	The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443
316401005460	substrate binding site [chemical binding]; other site
316401005461	putative dimerization interface [polypeptide binding]; other site
316401005462	PS00044 Bacterial regulatory proteins, lysR family signature.
316401005463	PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site.
316401005464	1 probable transmembrane helix predicted for ETEC1378 by TMHMM2.0 at aa 19-41
316401005465	aconitate hydratase; Validated; Region: PRK09277
316401005466	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
316401005467	substrate binding site [chemical binding]; other site
316401005468	ligand binding site [chemical binding]; other site
316401005469	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
316401005470	substrate binding site [chemical binding]; other site
316401005471	PS00450 Aconitase family signature 1.
316401005472	PS01244 Aconitase family signature 2.
316401005473	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
316401005474	dimerization interface [polypeptide binding]; other site
316401005475	active site
316401005476	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
316401005477	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
316401005478	active site
316401005479	Signal peptide predicted for ETEC1382 by SignalP 2.0 HMM (Signal peptide probability 0.890) with cleavage site probability 0.687 between residues 22 and 23
316401005480	6 probable transmembrane helices predicted for ETEC1382 by TMHMM2.0 at aa 7-29, 49-68, 75-92, 157-179, 186-208 and 212-229
316401005481	Predicted membrane protein [Function unknown]; Region: COG3771
316401005482	Signal peptide predicted for ETEC1383 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.704 between residues 22 and 23
316401005483	2 probable transmembrane helices predicted for ETEC1383 by TMHMM2.0 at aa 5-23 and 43-65
316401005484	Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956
316401005485	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
316401005486	TPR motif; other site
316401005487	binding surface
316401005488	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
316401005489	binding surface
316401005490	TPR motif; other site
316401005491	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
316401005492	active site
316401005493	dimer interface [polypeptide binding]; other site
316401005494	PS00156 Orotidine 5'-phosphate decarboxylase active site.
316401005495	translation initiation factor Sui1; Validated; Region: PRK06824
316401005496	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
316401005497	putative rRNA binding site [nucleotide binding]; other site
316401005498	PS01118 Translation initiation factor SUI1 signature.
316401005499	lipoprotein; Provisional; Region: PRK10540
316401005500	Signal peptide predicted for ETEC1387 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.672 between residues 25 and 26
316401005501	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
316401005502	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
316401005503	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
316401005504	RNase II stability modulator; Provisional; Region: PRK10060
316401005505	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316401005506	putative active site [active]
316401005507	heme pocket [chemical binding]; other site
316401005508	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316401005509	metal binding site [ion binding]; metal-binding site
316401005510	active site
316401005511	I-site; other site
316401005512	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
316401005513	exoribonuclease II; Provisional; Region: PRK05054
316401005514	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
316401005515	RNB domain; Region: RNB; pfam00773
316401005516	S1 RNA binding domain; Region: S1; pfam00575
316401005517	PS01175 Ribonuclease II family signature.
316401005518	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950
316401005519	Uncharacterized conserved protein [Function unknown]; Region: COG2128
316401005520	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984
316401005521	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
316401005522	NAD binding site [chemical binding]; other site
316401005523	homotetramer interface [polypeptide binding]; other site
316401005524	homodimer interface [polypeptide binding]; other site
316401005525	substrate binding site [chemical binding]; other site
316401005526	active site
316401005527	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
316401005528	putative active site [active]
316401005529	antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112
316401005530	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
316401005531	Walker A/P-loop; other site
316401005532	ATP binding site [chemical binding]; other site
316401005533	Q-loop/lid; other site
316401005534	ABC transporter signature motif; other site
316401005535	Walker B; other site
316401005536	D-loop; other site
316401005537	H-loop/switch region; other site
316401005538	PS00211 ABC transporters family signature.
316401005539	PS00017 ATP/GTP-binding site motif A (P-loop).
316401005540	antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093
316401005541	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
316401005542	Walker A/P-loop; other site
316401005543	ATP binding site [chemical binding]; other site
316401005544	Q-loop/lid; other site
316401005545	ABC transporter signature motif; other site
316401005546	Walker B; other site
316401005547	D-loop; other site
316401005548	H-loop/switch region; other site
316401005549	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
316401005550	PS00017 ATP/GTP-binding site motif A (P-loop).
316401005551	antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111
316401005552	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
316401005553	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401005554	dimer interface [polypeptide binding]; other site
316401005555	conserved gate region; other site
316401005556	putative PBP binding loops; other site
316401005557	ABC-ATPase subunit interface; other site
316401005558	5 probable transmembrane helices predicted for ETEC1396 by TMHMM2.0 at aa 30-52, 100-122, 137-170, 201-223 and 261-283
316401005559	antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110
316401005560	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401005561	dimer interface [polypeptide binding]; other site
316401005562	conserved gate region; other site
316401005563	putative PBP binding loops; other site
316401005564	ABC-ATPase subunit interface; other site
316401005565	5 probable transmembrane helices predicted for ETEC1397 by TMHMM2.0 at aa 9-31, 80-102, 109-131, 251-273 and 286-308
316401005566	Signal peptide predicted for ETEC1397 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.640 between residues 27 and 28
316401005567	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
316401005568	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
316401005569	peptide binding site [polypeptide binding]; other site
316401005570	PS01040 Bacterial extracellular solute-binding proteins, family 5 signature.
316401005571	Signal peptide predicted for ETEC1398 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 21 and 22
316401005572	Protein of unknown function (DUF2543); Region: DUF2543; pfam10820
316401005573	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
316401005574	12 probable transmembrane helices predicted for ETEC1400 by TMHMM2.0 at aa 21-40, 55-77, 98-120, 135-157, 162-182, 202-221, 242-264, 290-312, 341-360, 364-386, 399-418 and 423-442
316401005575	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
316401005576	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
316401005577	PS00181 Glutamine synthetase putative ATP-binding region signature.
316401005578	gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366
316401005579	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
316401005580	catalytic triad [active]
316401005581	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
316401005582	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
316401005583	non-specific DNA binding site [nucleotide binding]; other site
316401005584	salt bridge; other site
316401005585	sequence-specific DNA binding site [nucleotide binding]; other site
316401005586	Cupin domain; Region: Cupin_2; pfam07883
316401005587	gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847
316401005588	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
316401005589	NAD(P) binding site [chemical binding]; other site
316401005590	catalytic residues [active]
316401005591	PS00017 ATP/GTP-binding site motif A (P-loop).
316401005592	PS00687 Aldehyde dehydrogenases glutamic acid active site.
316401005593	PS00070 Aldehyde dehydrogenases cysteine active site.
316401005594	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
316401005595	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
316401005596	4-aminobutyrate transaminase; Provisional; Region: PRK09792
316401005597	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
316401005598	inhibitor-cofactor binding pocket; inhibition site
316401005599	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316401005600	catalytic residue [active]
316401005601	PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site.
316401005602	phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608
316401005603	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316401005604	Walker A motif; other site
316401005605	ATP binding site [chemical binding]; other site
316401005606	Walker B motif; other site
316401005607	arginine finger; other site
316401005608	PS00688 Sigma-54 interaction domain C-terminal part signature.
316401005609	PS00676 Sigma-54 interaction domain ATP-binding region B signature.
316401005610	phage shock protein PspA; Provisional; Region: PRK10698
316401005611	phage shock protein B; Provisional; Region: pspB; PRK09458
316401005612	1 probable transmembrane helix predicted for ETEC1409 by TMHMM2.0 at aa 4-26
316401005613	DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697
316401005614	phage shock protein C; Region: phageshock_pspC; TIGR02978
316401005615	1 probable transmembrane helix predicted for ETEC1410 by TMHMM2.0 at aa 39-61
316401005616	peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497
316401005617	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
316401005618	active site residue [active]
316401005619	Signal peptide predicted for ETEC1412 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 19 and 20
316401005620	Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356
316401005621	sucrose phosphorylase; Provisional; Region: PRK13840
316401005622	active site
316401005623	homodimer interface [polypeptide binding]; other site
316401005624	catalytic site [active]
316401005625	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
316401005626	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
316401005627	Signal peptide predicted for ETEC1414 by SignalP 2.0 HMM (Signal peptide probability 0.926) with cleavage site probability 0.610 between residues 23 and 24
316401005628	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
316401005629	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401005630	dimer interface [polypeptide binding]; other site
316401005631	conserved gate region; other site
316401005632	putative PBP binding loops; other site
316401005633	ABC-ATPase subunit interface; other site
316401005634	Signal peptide predicted for ETEC1415 by SignalP 2.0 HMM (Signal peptide probability 0.978) with cleavage site probability 0.904 between residues 30 and 31
316401005635	6 probable transmembrane helices predicted for ETEC1415 by TMHMM2.0 at aa 13-35, 76-98, 110-127, 164-186, 208-230 and 265-282
316401005636	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
316401005637	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
316401005638	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401005639	dimer interface [polypeptide binding]; other site
316401005640	conserved gate region; other site
316401005641	putative PBP binding loops; other site
316401005642	ABC-ATPase subunit interface; other site
316401005643	Signal peptide predicted for ETEC1416 by SignalP 2.0 HMM (Signal peptide probability 0.962) with cleavage site probability 0.694 between residues 32 and 33
316401005644	7 probable transmembrane helices predicted for ETEC1416 by TMHMM2.0 at aa 12-34, 78-100, 117-139, 143-165, 186-205, 215-237 and 242-264
316401005645	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
316401005646	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
316401005647	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
316401005648	putative NAD(P) binding site [chemical binding]; other site
316401005649	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
316401005650	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
316401005651	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
316401005652	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
316401005653	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
316401005654	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
316401005655	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
316401005656	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
316401005657	beta-phosphoglucomutase; Region: bPGM; TIGR01990
316401005658	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
316401005659	motif II; other site
316401005660	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
316401005661	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
316401005662	Walker A/P-loop; other site
316401005663	ATP binding site [chemical binding]; other site
316401005664	Q-loop/lid; other site
316401005665	ABC transporter signature motif; other site
316401005666	Walker B; other site
316401005667	D-loop; other site
316401005668	H-loop/switch region; other site
316401005669	TOBE domain; Region: TOBE_2; pfam08402
316401005670	PS00017 ATP/GTP-binding site motif A (P-loop).
316401005671	PS00211 ABC transporters family signature.
316401005672	Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381
316401005673	Signal peptide predicted for ETEC1423 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.848 between residues 21 and 22
316401005674	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401005675	Transcriptional regulators [Transcription]; Region: PurR; COG1609
316401005676	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
316401005677	DNA binding site [nucleotide binding]
316401005678	domain linker motif; other site
316401005679	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
316401005680	putative dimerization interface [polypeptide binding]; other site
316401005681	putative ligand binding site [chemical binding]; other site
316401005682	PS00356 Bacterial regulatory proteins, lacI family signature.
316401005683	Predicted ATPase [General function prediction only]; Region: COG3106
316401005684	PS00017 ATP/GTP-binding site motif A (P-loop).
316401005685	hypothetical protein; Provisional; Region: PRK05415
316401005686	TIGR01620 family protein; Region: hyp_HI0043
316401005687	3 probable transmembrane helices predicted for ETEC1426 by TMHMM2.0 at aa 70-89, 99-121 and 211-233
316401005688	DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820
316401005689	N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877
316401005690	putative aromatic amino acid binding site; other site
316401005691	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316401005692	Walker A motif; other site
316401005693	ATP binding site [chemical binding]; other site
316401005694	Walker B motif; other site
316401005695	arginine finger; other site
316401005696	PS00675 Sigma-54 interaction domain ATP-binding region A signature.
316401005697	PS00676 Sigma-54 interaction domain ATP-binding region B signature.
316401005698	PS00688 Sigma-54 interaction domain C-terminal part signature.
316401005699	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
316401005700	dimer interface [polypeptide binding]; other site
316401005701	catalytic triad [active]
316401005702	peroxidatic and resolving cysteines [active]
316401005703	PS01265 Tpx family signature.
316401005704	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
316401005705	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
316401005706	active site
316401005707	PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1.
316401005708	PS00909 Mandelate racemase / muconate lactonizing enzyme family signature 2.
316401005709	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
316401005710	Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904
316401005711	putative active site [active]
316401005712	Zn binding site [ion binding]; other site
316401005713	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
316401005714	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
316401005715	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
316401005716	Transcriptional regulator [Transcription]; Region: LysR; COG0583
316401005717	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401005718	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
316401005719	putative effector binding pocket; other site
316401005720	putative dimerization interface [polypeptide binding]; other site
316401005721	PS00044 Bacterial regulatory proteins, lysR family signature.
316401005722	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
316401005723	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
316401005724	peptide binding site [polypeptide binding]; other site
316401005725	Signal peptide predicted for ETEC1434 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.979 between residues 22 and 23
316401005726	PS01040 Bacterial extracellular solute-binding proteins, family 5 signature.
316401005727	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
316401005728	Mechanosensitive ion channel; Region: MS_channel; pfam00924
316401005729	PS01246 Uncharacterized protein family UPF0003 signature.
316401005730	4 probable transmembrane helices predicted for ETEC1435 by TMHMM2.0 at aa 10-32, 39-61, 76-98 and 126-148
316401005731	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401005732	Protein of unknown function (DUF2534); Region: DUF2534; pfam10749
316401005733	Signal peptide predicted for ETEC1436 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.868 between residues 32 and 33
316401005734	2 probable transmembrane helices predicted for ETEC1436 by TMHMM2.0 at aa 13-35 and 60-82
316401005735	universal stress protein UspE; Provisional; Region: PRK11175
316401005736	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
316401005737	Ligand Binding Site [chemical binding]; other site
316401005738	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
316401005739	Ligand Binding Site [chemical binding]; other site
316401005740	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
316401005741	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
316401005742	ligand binding site [chemical binding]; other site
316401005743	flexible hinge region; other site
316401005744	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
316401005745	putative switch regulator; other site
316401005746	non-specific DNA interactions [nucleotide binding]; other site
316401005747	DNA binding site [nucleotide binding]
316401005748	sequence specific DNA binding site [nucleotide binding]; other site
316401005749	putative cAMP binding site [chemical binding]; other site
316401005750	PS00042 Bacterial regulatory proteins, crp family signature.
316401005751	O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286
316401005752	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
316401005753	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
316401005754	DNA binding site [nucleotide binding]
316401005755	active site
316401005756	PS00374 Methylated-DNA--protein-cysteine methyltransferase active site.
316401005757	putative aminobenzoyl-glutamate transporter; Provisional; Region: abgT; PRK11339
316401005758	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
316401005759	13 probable transmembrane helices predicted for ETEC1440 by TMHMM2.0 at aa 30-52, 87-109, 121-139, 143-160, 165-187, 214-231, 259-281, 301-323, 344-366, 381-403, 408-430, 440-458 and 470-492
316401005760	M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673
316401005761	amidohydrolase; Region: amidohydrolases; TIGR01891
316401005762	putative metal binding site [ion binding]; other site
316401005763	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
316401005764	Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546
316401005765	metal binding site [ion binding]; metal-binding site
316401005766	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
316401005767	putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791
316401005768	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401005769	The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418
316401005770	putative substrate binding pocket [chemical binding]; other site
316401005771	putative dimerization interface [polypeptide binding]; other site
316401005772	PS00041 Bacterial regulatory proteins, araC family signature.
316401005773	PS00044 Bacterial regulatory proteins, lysR family signature.
316401005774	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
316401005775	Smr domain; Region: Smr; pfam01713
316401005776	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401005777	PAS domain S-box; Region: sensory_box; TIGR00229
316401005778	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316401005779	putative active site [active]
316401005780	heme pocket [chemical binding]; other site
316401005781	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
316401005782	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316401005783	metal binding site [ion binding]; metal-binding site
316401005784	active site
316401005785	I-site; other site
316401005786	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
316401005787	Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833
316401005788	Cl binding site [ion binding]; other site
316401005789	oligomer interface [polypeptide binding]; other site
316401005790	2 probable transmembrane helices predicted for ETEC1447 by TMHMM2.0 at aa 272-294 and 299-321
316401005791	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
316401005792	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
316401005793	ATP binding site [chemical binding]; other site
316401005794	Mg++ binding site [ion binding]; other site
316401005795	motif III; other site
316401005796	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
316401005797	nucleotide binding region [chemical binding]; other site
316401005798	ATP-binding site [chemical binding]; other site
316401005799	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
316401005800	putative RNA binding site [nucleotide binding]; other site
316401005801	PS00017 ATP/GTP-binding site motif A (P-loop).
316401005802	PS00039 DEAD-box subfamily ATP-dependent helicases signature.
316401005803	PS00017 ATP/GTP-binding site motif A (P-loop).
316401005804	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
316401005805	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
316401005806	Ligand Binding Site [chemical binding]; other site
316401005807	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
316401005808	Ligand Binding Site [chemical binding]; other site
316401005809	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
316401005810	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
316401005811	trimer interface [polypeptide binding]; other site
316401005812	eyelet of channel; other site
316401005813	PS00626 Regulator of chromosome condensation (RCC1) signature 2.
316401005814	Signal peptide predicted for ETEC1451 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 21 and 22
316401005815	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
316401005816	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
316401005817	dimer interface [polypeptide binding]; other site
316401005818	PYR/PP interface [polypeptide binding]; other site
316401005819	TPP binding site [chemical binding]; other site
316401005820	substrate binding site [chemical binding]; other site
316401005821	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
316401005822	Domain of unknown function; Region: EKR; smart00890
316401005823	4Fe-4S binding domain; Region: Fer4_6; pfam12837
316401005824	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
316401005825	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
316401005826	TPP-binding site [chemical binding]; other site
316401005827	dimer interface [polypeptide binding]; other site
316401005828	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401005829	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401005830	PS00024 Hemopexin domain signature.
316401005831	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
316401005832	Domain of unknown function (DUF333); Region: DUF333; pfam03891
316401005833	Signal peptide predicted for ETEC1453 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.773 between residues 24 and 25
316401005834	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401005835	heat-inducible protein; Provisional; Region: PRK10449
316401005836	Signal peptide predicted for ETEC1454 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.592 between residues 19 and 20
316401005837	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401005838	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
316401005839	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
316401005840	putative ligand binding site [chemical binding]; other site
316401005841	putative NAD binding site [chemical binding]; other site
316401005842	catalytic site [active]
316401005843	PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3.
316401005844	PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2.
316401005845	PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature.
316401005846	PS00017 ATP/GTP-binding site motif A (P-loop).
316401005847	hypothetical protein; Provisional; Region: PRK10695
316401005848	Signal peptide predicted for ETEC1456 by SignalP 2.0 HMM (Signal peptide probability 0.984) with cleavage site probability 0.670 between residues 34 and 35
316401005849	1 probable transmembrane helix predicted for ETEC1456 by TMHMM2.0 at aa 7-29
316401005850	PS00591 Glycosyl hydrolases family 10 active site.
316401005851	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
316401005852	Signal peptide predicted for ETEC1457 by SignalP 2.0 HMM (Signal peptide probability 0.979) with cleavage site probability 0.755 between residues 24 and 25
316401005853	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401005854	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784
316401005855	Signal peptide predicted for ETEC1458 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 21 and 22
316401005856	1 probable transmembrane helix predicted for ETEC1458 by TMHMM2.0 at aa 5-24
316401005857	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
316401005858	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316401005859	Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; Region: ALDH_PADH_NahF; cd07113
316401005860	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
316401005861	NAD(P) binding site [chemical binding]; other site
316401005862	catalytic residues [active]
316401005863	PS00687 Aldehyde dehydrogenases glutamic acid active site.
316401005864	PS00070 Aldehyde dehydrogenases cysteine active site.
316401005865	tyramine oxidase; Provisional; Region: tynA; PRK14696
316401005866	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
316401005867	Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727
316401005868	Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728
316401005869	Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179
316401005870	PS01165 Copper amine oxidase copper-binding site signature.
316401005871	PS01164 Copper amine oxidase topaquinone signature.
316401005872	Signal peptide predicted for ETEC1461 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.916 between residues 30 and 31
316401005873	bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563
316401005874	N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128
316401005875	substrate binding site [chemical binding]; other site
316401005876	dimer interface [polypeptide binding]; other site
316401005877	NADP binding site [chemical binding]; other site
316401005878	catalytic residues [active]
316401005879	MaoC_C  The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452
316401005880	substrate binding site [chemical binding]; other site
316401005881	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
316401005882	phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
316401005883	phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781
316401005884	phenylacetate-CoA oxygenase, PaaI subunit; Region: PA_CoA_Oxy3; TIGR02158
316401005885	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
316401005886	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
316401005887	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
316401005888	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
316401005889	FAD binding pocket [chemical binding]; other site
316401005890	FAD binding motif [chemical binding]; other site
316401005891	phosphate binding motif [ion binding]; other site
316401005892	beta-alpha-beta structure motif; other site
316401005893	NAD(p) ribose binding residues [chemical binding]; other site
316401005894	NAD binding pocket [chemical binding]; other site
316401005895	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
316401005896	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
316401005897	catalytic loop [active]
316401005898	iron binding site [ion binding]; other site
316401005899	PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature.
316401005900	enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674
316401005901	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
316401005902	substrate binding site [chemical binding]; other site
316401005903	oxyanion hole (OAH) forming residues; other site
316401005904	trimer interface [polypeptide binding]; other site
316401005905	PS00166 Enoyl-CoA hydratase/isomerase signature.
316401005906	enoyl-CoA hydratase; Provisional; Region: PRK08140
316401005907	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
316401005908	substrate binding site [chemical binding]; other site
316401005909	oxyanion hole (OAH) forming residues; other site
316401005910	trimer interface [polypeptide binding]; other site
316401005911	3-hydroxyacyl-CoA dehydrogenase PaaC; Region: PaaC-3OHAcCoADH; TIGR02279
316401005912	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
316401005913	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
316401005914	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
316401005915	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
316401005916	CoenzymeA binding site [chemical binding]; other site
316401005917	subunit interaction site [polypeptide binding]; other site
316401005918	PHB binding site; other site
316401005919	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
316401005920	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
316401005921	dimer interface [polypeptide binding]; other site
316401005922	active site
316401005923	PS00098 Thiolases acyl-enzyme intermediate signature.
316401005924	PS00737 Thiolases signature 2.
316401005925	PS00099 Thiolases active site.
316401005926	Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913
316401005927	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
316401005928	active site
316401005929	AMP binding site [chemical binding]; other site
316401005930	homodimer interface [polypeptide binding]; other site
316401005931	acyl-activating enzyme (AAE) consensus motif; other site
316401005932	CoA binding site [chemical binding]; other site
316401005933	PS00190 Cytochrome c family heme-binding site signature.
316401005934	PaaX-like protein; Region: PaaX; pfam07848
316401005935	phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277
316401005936	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
316401005937	phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287
316401005938	paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745
316401005939	putative trimer interface [polypeptide binding]; other site
316401005940	putative metal binding site [ion binding]; other site
316401005941	Autotransporter beta-domain; Region: Autotransporter; pfam03797
316401005942	Signal peptide predicted for ETEC1476 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 21 and 22
316401005943	PS00761 Signal peptidases I signature 3.
316401005944	PS00639 Eukaryotic thiol (cysteine) proteases histidine active site.
316401005945	PS00639 Eukaryotic thiol (cysteine) proteases histidine active site.
316401005946	PS00639 Eukaryotic thiol (cysteine) proteases histidine active site.
316401005947	PS00639 Eukaryotic thiol (cysteine) proteases histidine active site.
316401005948	PS00639 Eukaryotic thiol (cysteine) proteases histidine active site.
316401005949	PS00639 Eukaryotic thiol (cysteine) proteases histidine active site.
316401005950	PS00639 Eukaryotic thiol (cysteine) proteases histidine active site.
316401005951	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
316401005952	Protein of unknown function (DUF433); Region: DUF433; cl01030
316401005953	MULE transposase domain; Region: MULE; pfam10551
316401005954	PS01007 Transposases, Mutator family, signature.
316401005955	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
316401005956	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
316401005957	active site
316401005958	catalytic tetrad [active]
316401005959	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
316401005960	Protein of unknown function (DUF2773); Region: DUF2773; pfam10971
316401005961	Signal peptide predicted for ETEC1479 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.994 between residues 24 and 25
316401005962	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
316401005963	Signal peptide predicted for ETEC1480 by SignalP 2.0 HMM (Signal peptide probability 0.976) with cleavage site probability 0.960 between residues 50 and 51
316401005964	5 probable transmembrane helices predicted for ETEC1480 by TMHMM2.0 at aa 31-64, 85-107, 117-139, 152-169 and 174-196
316401005965	PS00237 G-protein coupled receptors signature.
316401005966	Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589
316401005967	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
316401005968	9 probable transmembrane helices predicted for ETEC1481 by TMHMM2.0 at aa 5-24, 37-56, 61-83, 95-117, 137-159, 166-188, 208-230, 237-256 and 276-293
316401005969	PS00017 ATP/GTP-binding site motif A (P-loop).
316401005970	PS01315 Phosphatidate cytidylyltransferase signature.
316401005971	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
316401005972	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
316401005973	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316401005974	S-adenosylmethionine binding site [chemical binding]; other site
316401005975	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
316401005976	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
316401005977	active site
316401005978	Dual specificity phosphatase, catalytic domain; Region: DSPc; smart00195
316401005979	active site
316401005980	catalytic residues [active]
316401005981	Signal peptide predicted for ETEC1483 by SignalP 2.0 HMM (Signal peptide probability 0.890) with cleavage site probability 0.723 between residues 26 and 27
316401005982	8 probable transmembrane helices predicted for ETEC1483 by TMHMM2.0 at aa 7-29, 49-71, 83-105, 120-142, 155-172, 176-195, 211-233 and 238-260
316401005983	PS00383 Tyrosine specific protein phosphatases active site.
316401005984	azoreductase; Reviewed; Region: PRK00170
316401005985	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
316401005986	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
316401005987	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
316401005988	ATP binding site [chemical binding]; other site
316401005989	putative Mg++ binding site [ion binding]; other site
316401005990	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
316401005991	nucleotide binding region [chemical binding]; other site
316401005992	ATP-binding site [chemical binding]; other site
316401005993	Helicase associated domain (HA2); Region: HA2; pfam04408
316401005994	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
316401005995	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
316401005996	PS00017 ATP/GTP-binding site motif A (P-loop).
316401005997	Uncharacterized conserved protein [Function unknown]; Region: COG1434
316401005998	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
316401005999	putative active site [active]
316401006000	Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088
316401006001	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
316401006002	NAD binding site [chemical binding]; other site
316401006003	catalytic residues [active]
316401006004	substrate binding site [chemical binding]; other site
316401006005	PS00687 Aldehyde dehydrogenases glutamic acid active site.
316401006006	PS00070 Aldehyde dehydrogenases cysteine active site.
316401006007	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
316401006008	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
316401006009	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
316401006010	PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site.
316401006011	PS00430 TonB-dependent receptor proteins signature 1.
316401006012	cytochrome b561; Provisional; Region: PRK11513
316401006013	4 probable transmembrane helices predicted for ETEC1489 by TMHMM2.0 at aa 12-34, 40-62, 83-105 and 140-162
316401006014	hypothetical protein; Provisional; Region: PRK10040
316401006015	Signal peptide predicted for ETEC1490 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.999 between residues 20 and 21
316401006016	small toxic polypeptide; Provisional; Region: PRK09738
316401006017	1 probable transmembrane helix predicted for ETEC1491 by TMHMM2.0 at aa 7-29
316401006018	PS00556 Hok/gef family cell toxic proteins signature.
316401006019	Signal peptide predicted for ETEC1491 by SignalP 2.0 HMM (Signal peptide probability 0.938) with cleavage site probability 0.874 between residues 24 and 25
316401006020	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
316401006021	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
316401006022	dimer interface [polypeptide binding]; other site
316401006023	ligand binding site [chemical binding]; other site
316401006024	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
316401006025	dimerization interface [polypeptide binding]; other site
316401006026	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316401006027	dimer interface [polypeptide binding]; other site
316401006028	putative CheW interface [polypeptide binding]; other site
316401006029	Signal peptide predicted for ETEC1493 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.823 between residues 39 and 40
316401006030	2 probable transmembrane helices predicted for ETEC1493 by TMHMM2.0 at aa 20-42 and 199-221
316401006031	PS00538 Bacterial chemotaxis sensory transducers signature.
316401006032	PS00287 Cysteine proteases inhibitors signature.
316401006033	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
316401006034	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401006035	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
316401006036	dimerization interface [polypeptide binding]; other site
316401006037	PS00044 Bacterial regulatory proteins, lysR family signature.
316401006038	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
316401006039	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
316401006040	PS00237 G-protein coupled receptors signature.
316401006041	PS00294 Prenyl group binding site (CAAX box).
316401006042	Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131
316401006043	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
316401006044	Signal peptide predicted for ETEC1496 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 22 and 23
316401006045	hypothetical protein; Provisional; Region: PRK11415
316401006046	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
316401006047	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
316401006048	Coenzyme A binding pocket [chemical binding]; other site
316401006049	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
316401006050	putative trimer interface [polypeptide binding]; other site
316401006051	putative CoA binding site [chemical binding]; other site
316401006052	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208
316401006053	putative trimer interface [polypeptide binding]; other site
316401006054	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
316401006055	putative CoA binding site [chemical binding]; other site
316401006056	putative trimer interface [polypeptide binding]; other site
316401006057	putative CoA binding site [chemical binding]; other site
316401006058	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
316401006059	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324
316401006060	gating phenylalanine in ion channel; other site
316401006061	8 probable transmembrane helices predicted for ETEC1500 by TMHMM2.0 at aa 7-29, 44-66, 79-101, 157-179, 200-219, 229-247, 254-276 and 286-308
316401006062	tellurite resistance protein TehB; Provisional; Region: PRK11207
316401006063	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316401006064	S-adenosylmethionine binding site [chemical binding]; other site
316401006065	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
316401006066	Signal peptide predicted for ETEC1502 by SignalP 2.0 HMM (Signal peptide probability 0.992) with cleavage site probability 0.586 between residues 24 and 25
316401006067	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401006068	Similar, but truncated at the N and C termini, to Escherichia coli E24377A transposase, is605 family. UniProt:A7ZMR8 (315 aa) fasta scores: E()=5.5e-40, 96.154% id in 104 aa
316401006069	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
316401006070	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
316401006071	Probable transposase; Region: OrfB_IS605; pfam01385
316401006072	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
316401006073	Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135
316401006074	benzoate transporter; Region: benE; TIGR00843
316401006075	10 probable transmembrane helices predicted for ETEC1504 by TMHMM2.0 at aa 10-30, 43-65, 92-114, 121-143, 163-185, 206-225, 245-267, 288-310, 315-337 and 350-372
316401006076	PS00041 Bacterial regulatory proteins, araC family signature.
316401006077	Signal peptide predicted for ETEC1504 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.651 between residues 25 and 26
316401006078	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
316401006079	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
316401006080	non-specific DNA binding site [nucleotide binding]; other site
316401006081	salt bridge; other site
316401006082	sequence-specific DNA binding site [nucleotide binding]; other site
316401006083	Cupin domain; Region: Cupin_2; pfam07883
316401006084	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
316401006085	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
316401006086	Peptidase family U32; Region: Peptidase_U32; pfam01136
316401006087	Collagenase; Region: DUF3656; pfam12392
316401006088	PS01276 Peptidase family U32 signature.
316401006089	Protein of unknown function (DUF2554); Region: DUF2554; pfam10829
316401006090	Signal peptide predicted for ETEC1507 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 22 and 23
316401006091	YcfA-like protein; Region: YcfA; pfam07927
316401006092	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
316401006093	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
316401006094	sequence-specific DNA binding site [nucleotide binding]; other site
316401006095	salt bridge; other site
316401006096	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
316401006097	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
316401006098	DNA-binding site [nucleotide binding]; DNA binding site
316401006099	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
316401006100	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316401006101	homodimer interface [polypeptide binding]; other site
316401006102	catalytic residue [active]
316401006103	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
316401006104	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
316401006105	Signal peptide predicted for ETEC1511 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 22 and 23
316401006106	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
316401006107	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316401006108	Walker A/P-loop; other site
316401006109	ATP binding site [chemical binding]; other site
316401006110	Q-loop/lid; other site
316401006111	ABC transporter signature motif; other site
316401006112	Walker B; other site
316401006113	D-loop; other site
316401006114	H-loop/switch region; other site
316401006115	TOBE domain; Region: TOBE_2; pfam08402
316401006116	PS00017 ATP/GTP-binding site motif A (P-loop).
316401006117	PS00211 ABC transporters family signature.
316401006118	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401006119	dimer interface [polypeptide binding]; other site
316401006120	conserved gate region; other site
316401006121	putative PBP binding loops; other site
316401006122	ABC-ATPase subunit interface; other site
316401006123	PS00430 TonB-dependent receptor proteins signature 1.
316401006124	8 probable transmembrane helices predicted for ETEC1513 by TMHMM2.0 at aa 30-52, 88-110, 123-145, 155-177, 184-206, 229-251, 256-275 and 285-304
316401006125	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
316401006126	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
316401006127	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401006128	ABC-ATPase subunit interface; other site
316401006129	6 probable transmembrane helices predicted for ETEC1514 by TMHMM2.0 at aa 12-34, 71-93, 100-122, 132-154, 180-202 and 234-256
316401006130	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
316401006131	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
316401006132	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
316401006133	tetrameric interface [polypeptide binding]; other site
316401006134	NAD binding site [chemical binding]; other site
316401006135	catalytic residues [active]
316401006136	substrate binding site [chemical binding]; other site
316401006137	PS00687 Aldehyde dehydrogenases glutamic acid active site.
316401006138	Protein of unknown function (DUF2566); Region: DUF2566; pfam10753
316401006139	2 probable transmembrane helices predicted for ETEC1516 by TMHMM2.0 at aa 24-43 and 50-72
316401006140	Protein of unknown function (DUF2526); Region: DUF2526; pfam10735
316401006141	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
316401006142	5 probable transmembrane helices predicted for ETEC1518 by TMHMM2.0 at aa 5-27, 32-54, 69-88, 95-117 and 122-144
316401006143	Signal peptide predicted for ETEC1518 by SignalP 2.0 HMM (Signal peptide probability 0.775) with cleavage site probability 0.486 between residues 20 and 21
316401006144	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
316401006145	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
316401006146	Coenzyme A binding pocket [chemical binding]; other site
316401006147	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
316401006148	Prostaglandin dehydrogenases; Region: PGDH; cd05288
316401006149	NAD(P) binding site [chemical binding]; other site
316401006150	substrate binding site [chemical binding]; other site
316401006151	dimer interface [polypeptide binding]; other site
316401006152	colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414
316401006153	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
316401006154	DNA-binding site [nucleotide binding]; DNA binding site
316401006155	FCD domain; Region: FCD; pfam07729
316401006156	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
316401006157	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
316401006158	N-terminal plug; other site
316401006159	ligand-binding site [chemical binding]; other site
316401006160	Signal peptide predicted for ETEC1522 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 23 and 24
316401006161	PQQ-like domain; Region: PQQ_2; pfam13360
316401006162	Signal peptide predicted for ETEC1523 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 30 and 31
316401006163	PS00017 ATP/GTP-binding site motif A (P-loop).
316401006164	L-asparagine permease; Provisional; Region: PRK15049
316401006165	12 probable transmembrane helices predicted for ETEC1524 by TMHMM2.0 at aa 37-59, 64-86, 107-129, 144-166, 171-193, 213-235, 260-282, 302-324, 351-373, 377-399, 420-442 and 446-468
316401006166	PS00218 Amino acid permeases signature.
316401006167	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
316401006168	C-terminal domain interface [polypeptide binding]; other site
316401006169	GSH binding site (G-site) [chemical binding]; other site
316401006170	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
316401006171	dimer interface [polypeptide binding]; other site
316401006172	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
316401006173	dimer interface [polypeptide binding]; other site
316401006174	N-terminal domain interface [polypeptide binding]; other site
316401006175	substrate binding pocket (H-site) [chemical binding]; other site
316401006176	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
316401006177	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
316401006178	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
316401006179	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
316401006180	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
316401006181	RHS Repeat; Region: RHS_repeat; pfam05593
316401006182	RHS Repeat; Region: RHS_repeat; pfam05593
316401006183	RHS Repeat; Region: RHS_repeat; pfam05593
316401006184	RHS Repeat; Region: RHS_repeat; pfam05593
316401006185	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
316401006186	RHS Repeat; Region: RHS_repeat; pfam05593
316401006187	RHS Repeat; Region: RHS_repeat; pfam05593
316401006188	RHS protein; Region: RHS; pfam03527
316401006189	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
316401006190	1 probable transmembrane helix predicted for ETEC1529 by TMHMM2.0 at aa 7-25
316401006192	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
316401006193	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
316401006194	Transposase [DNA replication, recombination, and repair]; Region: COG5433
316401006195	Transposase [DNA replication, recombination, and repair]; Region: COG5433
316401006196	4-oxalocrotonate tautomerase; Provisional; Region: PRK01271
316401006197	active site 1 [active]
316401006198	dimer interface [polypeptide binding]; other site
316401006199	hexamer interface [polypeptide binding]; other site
316401006200	active site 2 [active]
316401006201	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
316401006202	N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047
316401006203	hypothetical protein; Provisional; Region: PRK10281
316401006204	respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351
316401006205	5 probable transmembrane helices predicted for ETEC1536 by TMHMM2.0 at aa 10-29, 50-69, 89-111, 128-150 and 185-207
316401006206	nitrate reductase 2 subunit delta; Provisional; Region: PRK15054
316401006207	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
316401006208	PS00190 Cytochrome c family heme-binding site signature.
316401006209	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
316401006210	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
316401006211	[4Fe-4S] binding site [ion binding]; other site
316401006212	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
316401006213	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
316401006214	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
316401006215	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
316401006216	molybdopterin cofactor binding site; other site
316401006217	PS00932 Prokaryotic molybdopterin oxidoreductases signature 3.
316401006218	PS00490 Prokaryotic molybdopterin oxidoreductases signature 2.
316401006219	PS00551 Prokaryotic molybdopterin oxidoreductases signature 1.
316401006221	potential frameshift: common BLAST hit: gi|260867911|ref|YP_003234313.1| T3SS effector-like protein EspR
316401006222	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
316401006223	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
316401006224	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
316401006225	Signal peptide predicted for ETEC1543 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 21 and 22
316401006226	aromatic amino acid exporter; Provisional; Region: PRK11689
316401006227	9 probable transmembrane helices predicted for ETEC1544 by TMHMM2.0 at aa 15-37, 44-66, 76-94, 101-120, 135-157, 164-186, 196-218, 225-247 and 251-270
316401006228	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
316401006229	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
316401006230	[4Fe-4S] binding site [ion binding]; other site
316401006231	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
316401006232	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
316401006233	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
316401006234	molybdopterin cofactor binding site; other site
316401006235	PS00551 Prokaryotic molybdopterin oxidoreductases signature 1.
316401006236	PS00932 Prokaryotic molybdopterin oxidoreductases signature 3.
316401006237	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
316401006238	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
316401006239	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401006240	1 probable transmembrane helix predicted for ETEC1546 by TMHMM2.0 at aa 260-279
316401006241	formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179
316401006242	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
316401006243	Signal peptide predicted for ETEC1547 by SignalP 2.0 HMM (Signal peptide probability 0.630) with cleavage site probability 0.357 between residues 41 and 42
316401006244	4 probable transmembrane helices predicted for ETEC1547 by TMHMM2.0 at aa 21-40, 55-77, 117-139 and 154-176
316401006245	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
316401006246	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
316401006247	NAD binding site [chemical binding]; other site
316401006248	substrate binding site [chemical binding]; other site
316401006249	catalytic Zn binding site [ion binding]; other site
316401006250	tetramer interface [polypeptide binding]; other site
316401006251	structural Zn binding site [ion binding]; other site
316401006252	PS00059 Zinc-containing alcohol dehydrogenases signature.
316401006253	PS00190 Cytochrome c family heme-binding site signature.
316401006254	malate dehydrogenase; Provisional; Region: PRK13529
316401006255	Malic enzyme, N-terminal domain; Region: malic; pfam00390
316401006256	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
316401006257	NAD(P) binding site [chemical binding]; other site
316401006258	PS00331 Malic enzymes signature.
316401006259	30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057
316401006260	Putative biofilm-dependent modulation protein; Region: BDM; cl11581
316401006261	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
316401006262	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
316401006263	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
316401006264	Walker A/P-loop; other site
316401006265	ATP binding site [chemical binding]; other site
316401006266	Q-loop/lid; other site
316401006267	ABC transporter signature motif; other site
316401006268	Walker B; other site
316401006269	D-loop; other site
316401006270	H-loop/switch region; other site
316401006271	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
316401006272	PS00211 ABC transporters family signature.
316401006273	PS00017 ATP/GTP-binding site motif A (P-loop).
316401006274	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
316401006275	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
316401006276	Walker A/P-loop; other site
316401006277	ATP binding site [chemical binding]; other site
316401006278	Q-loop/lid; other site
316401006279	ABC transporter signature motif; other site
316401006280	Walker B; other site
316401006281	D-loop; other site
316401006282	H-loop/switch region; other site
316401006283	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
316401006284	PS00211 ABC transporters family signature.
316401006285	PS00017 ATP/GTP-binding site motif A (P-loop).
316401006286	D-ala-D-ala transporter subunit; Provisional; Region: PRK09881
316401006287	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
316401006288	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401006289	dimer interface [polypeptide binding]; other site
316401006290	conserved gate region; other site
316401006291	putative PBP binding loops; other site
316401006292	ABC-ATPase subunit interface; other site
316401006293	5 probable transmembrane helices predicted for ETEC1555 by TMHMM2.0 at aa 32-54, 99-121, 142-164, 217-239 and 260-282
316401006294	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
316401006295	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
316401006296	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401006297	dimer interface [polypeptide binding]; other site
316401006298	conserved gate region; other site
316401006299	putative PBP binding loops; other site
316401006300	ABC-ATPase subunit interface; other site
316401006301	7 probable transmembrane helices predicted for ETEC1556 by TMHMM2.0 at aa 12-34, 103-125, 138-160, 196-218, 247-269, 273-295 and 308-330
316401006302	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
316401006304	D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178
316401006305	cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359
316401006306	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316401006307	putative active site [active]
316401006308	heme pocket [chemical binding]; other site
316401006309	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316401006310	putative active site [active]
316401006311	heme pocket [chemical binding]; other site
316401006312	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316401006313	metal binding site [ion binding]; metal-binding site
316401006314	active site
316401006315	I-site; other site
316401006316	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
316401006317	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
316401006318	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316401006319	metal binding site [ion binding]; metal-binding site
316401006320	active site
316401006321	I-site; other site
316401006322	Signal peptide predicted for ETEC1560 by SignalP 2.0 HMM (Signal peptide probability 0.650) with cleavage site probability 0.482 between residues 17 and 18
316401006323	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
316401006324	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
316401006325	Signal peptide predicted for ETEC1561 by SignalP 2.0 HMM (Signal peptide probability 0.902) with cleavage site probability 0.465 between residues 30 and 31
316401006326	glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910
316401006327	12 probable transmembrane helices predicted for ETEC1562 by TMHMM2.0 at aa 13-30, 40-62, 95-117, 132-151, 158-180, 195-217, 238-260, 288-310, 335-357, 372-394, 407-429 and 444-466
316401006328	Signal peptide predicted for ETEC1562 by SignalP 2.0 HMM (Signal peptide probability 0.955) with cleavage site probability 0.905 between residues 28 and 29
316401006329	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
316401006330	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316401006331	catalytic residue [active]
316401006332	PS00392 DDC / GAD / HDC / TyrDC pyridoxal-phosphate attachment site.
316401006333	PS01039 Bacterial extracellular solute-binding proteins, family 3 signature.
316401006334	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
316401006335	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
316401006336	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
316401006337	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
316401006338	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
316401006339	PS00143 Insulinase family, zinc-binding region signature.
316401006340	1 probable transmembrane helix predicted for ETEC1564 by TMHMM2.0 at aa 7-29
316401006341	Signal peptide predicted for ETEC1564 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.943 between residues 26 and 27
316401006342	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
316401006343	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
316401006344	PS00017 ATP/GTP-binding site motif A (P-loop).
316401006345	Signal peptide predicted for ETEC1565 by SignalP 2.0 HMM (Signal peptide probability 0.779) with cleavage site probability 0.636 between residues 19 and 20
316401006346	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
316401006347	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
316401006348	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
316401006349	PS00211 ABC transporters family signature.
316401006350	PS00017 ATP/GTP-binding site motif A (P-loop).
316401006351	5 probable transmembrane helices predicted for ETEC1566 by TMHMM2.0 at aa 30-52, 72-94, 151-173, 188-210 and 284-306
316401006352	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
316401006353	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316401006354	FeS/SAM binding site; other site
316401006355	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
316401006356	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
316401006357	Sulfatase; Region: Sulfatase; pfam00884
316401006358	Signal peptide predicted for ETEC1568 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.995 between residues 29 and 30
316401006359	transcriptional regulator YdeO; Provisional; Region: PRK09940
316401006360	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316401006361	PS00041 Bacterial regulatory proteins, araC family signature.
316401006362	putative oxidoreductase; Provisional; Region: PRK09939
316401006363	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
316401006364	putative molybdopterin cofactor binding site [chemical binding]; other site
316401006365	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
316401006366	putative molybdopterin cofactor binding site; other site
316401006367	Mannose binding  domain of FimH and related proteins; Region: FimH_man-bind; cd10466
316401006368	mannosyl binding site [chemical binding]; other site
316401006369	Signal peptide predicted for ETEC1571 by SignalP 2.0 HMM (Signal peptide probability 0.979) with cleavage site probability 0.966 between residues 24 and 25
316401006370	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
316401006371	Signal peptide predicted for ETEC1572 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 23 and 24
316401006372	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
316401006373	IS2 repressor TnpA; Reviewed; Region: PRK09413
316401006374	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
316401006375	IS2 transposase TnpB; Reviewed; Region: PRK09409
316401006376	HTH-like domain; Region: HTH_21; pfam13276
316401006377	Integrase core domain; Region: rve; pfam00665
316401006378	Integrase core domain; Region: rve_3; pfam13683
316401006379	Similar to C-terminus of Escherichia coli (strain K12) fimd outer membrane usher protein fimd precursor. UniProt:P30130 (878 aa) fasta scores: E()=8.2e-36, 59.006% id in 161 aa, and to C-terminus of Escherichia coli (strain k12). ydet UniProt:P76137 (EMBL:U00096 (382 aa) fasta scores: E()=2.3e-60, 100.000% id in 161 aa
316401006380	HipA N-terminal domain; Region: Couple_hipA; pfam13657
316401006381	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
316401006382	HipA-like N-terminal domain; Region: HipA_N; pfam07805
316401006383	HipA-like C-terminal domain; Region: HipA_C; pfam07804
316401006384	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
316401006385	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
316401006386	non-specific DNA binding site [nucleotide binding]; other site
316401006387	salt bridge; other site
316401006388	sequence-specific DNA binding site [nucleotide binding]; other site
316401006389	potential frameshift: common BLAST hit: gi|378713086|ref|YP_005277979.1| outer membrane autotransporter barrel domain-containing protein
316401006390	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
316401006391	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
316401006392	Autotransporter beta-domain; Region: Autotransporter; pfam03797
316401006393	putative lipoprotein/autotransporter domain-containing protein; Provisional; Region: PRK14849
316401006394	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
316401006395	PS00017 ATP/GTP-binding site motif A (P-loop).
316401006396	Signal peptide predicted for ETEC1580 by SignalP 2.0 HMM (Signal peptide probability 0.976) with cleavage site probability 0.949 between residues 61 and 62
316401006397	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401006398	autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939
316401006399	Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775
316401006400	putative N- and C-terminal domain interface [polypeptide binding]; other site
316401006401	putative active site [active]
316401006402	putative MgATP binding site [chemical binding]; other site
316401006403	catalytic site [active]
316401006404	metal binding site [ion binding]; metal-binding site
316401006405	putative carbohydrate binding site [chemical binding]; other site
316401006406	transcriptional regulator LsrR; Provisional; Region: PRK15418
316401006407	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
316401006408	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
316401006409	autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439
316401006410	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
316401006411	Walker A/P-loop; other site
316401006412	ATP binding site [chemical binding]; other site
316401006413	Q-loop/lid; other site
316401006414	ABC transporter signature motif; other site
316401006415	Walker B; other site
316401006416	D-loop; other site
316401006417	H-loop/switch region; other site
316401006418	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
316401006419	PS00017 ATP/GTP-binding site motif A (P-loop).
316401006420	PS00211 ABC transporters family signature.
316401006421	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
316401006422	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
316401006423	TM-ABC transporter signature motif; other site
316401006424	Signal peptide predicted for ETEC1584 by SignalP 2.0 HMM (Signal peptide probability 0.674) with cleavage site probability 0.613 between residues 27 and 28
316401006425	9 probable transmembrane helices predicted for ETEC1584 by TMHMM2.0 at aa 13-27, 37-59, 66-85, 90-112, 119-141, 156-178, 208-230, 250-272 and 279-301
316401006426	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
316401006427	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
316401006428	TM-ABC transporter signature motif; other site
316401006429	9 probable transmembrane helices predicted for ETEC1585 by TMHMM2.0 at aa 7-26, 36-58, 65-84, 88-110, 123-145, 160-182, 211-233, 248-279 and 292-311
316401006430	autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408
316401006431	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
316401006432	ligand binding site [chemical binding]; other site
316401006433	Signal peptide predicted for ETEC1586 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 26 and 27
316401006434	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
316401006435	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
316401006436	putative active site; other site
316401006437	catalytic residue [active]
316401006438	PS00225 Crystallins beta and gamma 'Greek key' motif signature.
316401006439	autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486
316401006440	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
316401006441	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316401006442	S-adenosylmethionine binding site [chemical binding]; other site
316401006443	Predicted membrane protein [Function unknown]; Region: COG3781
316401006444	3 probable transmembrane helices predicted for ETEC1590 by TMHMM2.0 at aa 20-42, 52-74 and 218-240
316401006445	altronate oxidoreductase; Provisional; Region: PRK03643
316401006446	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
316401006447	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
316401006448	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
316401006449	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316401006450	metal binding site [ion binding]; metal-binding site
316401006451	active site
316401006452	I-site; other site
316401006453	3 probable transmembrane helices predicted for ETEC1592 by TMHMM2.0 at aa 20-42, 61-83 and 98-120
316401006454	3 probable transmembrane helices predicted for ETEC1592A by TMHMM2.0 at aa 22-41, 62-84 and 88-110
316401006455	Domain of unknown function (DUF4186); Region: DUF4186; pfam13811
316401006456	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
316401006457	glutaminase; Provisional; Region: PRK00971
316401006458	putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968
316401006459	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
316401006460	NAD(P) binding site [chemical binding]; other site
316401006461	catalytic residues [active]
316401006462	PS00070 Aldehyde dehydrogenases cysteine active site.
316401006463	Transcriptional regulator [Transcription]; Region: LysR; COG0583
316401006464	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401006465	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
316401006466	putative dimerization interface [polypeptide binding]; other site
316401006467	PS00044 Bacterial regulatory proteins, lysR family signature.
316401006468	putative arabinose transporter; Provisional; Region: PRK03545
316401006469	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401006470	putative substrate translocation pore; other site
316401006471	12 probable transmembrane helices predicted for ETEC1598 by TMHMM2.0 at aa 12-34, 49-71, 80-99, 104-126, 138-160, 170-192, 204-226, 246-265, 272-294, 304-326, 333-352 and 362-384
316401006472	inner membrane protein; Provisional; Region: PRK10995
316401006473	5 probable transmembrane helices predicted for ETEC1599 by TMHMM2.0 at aa 10-32, 44-66, 71-93, 150-172 and 192-214
316401006474	DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512
316401006475	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
316401006476	PS01117 Bacterial regulatory proteins, marR family signature.
316401006477	PS00190 Cytochrome c family heme-binding site signature.
316401006478	DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511
316401006479	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316401006480	PS00041 Bacterial regulatory proteins, araC family signature.
316401006481	hypothetical protein; Provisional; Region: PRK10106
316401006482	Signal peptide predicted for ETEC1602 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.964 between residues 21 and 22
316401006483	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
316401006484	EamA-like transporter family; Region: EamA; pfam00892
316401006485	EamA-like transporter family; Region: EamA; pfam00892
316401006486	10 probable transmembrane helices predicted for ETEC1603 by TMHMM2.0 at aa 7-29, 33-52, 61-83, 87-109, 116-135, 140-162, 174-196, 211-233, 246-263 and 267-289
316401006487	putative transporter; Provisional; Region: PRK10054
316401006488	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401006489	putative substrate translocation pore; other site
316401006490	Signal peptide predicted for ETEC1604 by SignalP 2.0 HMM (Signal peptide probability 0.988) with cleavage site probability 0.798 between residues 24 and 25
316401006491	12 probable transmembrane helices predicted for ETEC1604 by TMHMM2.0 at aa 12-34, 44-66, 75-94, 99-121, 134-156, 160-182, 208-230, 245-264, 271-293, 298-320, 341-360 and 364-381
316401006492	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
316401006493	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
316401006494	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316401006495	metal binding site [ion binding]; metal-binding site
316401006496	active site
316401006497	I-site; other site
316401006498	IS1 transposase; Region: DDE_Tnp_IS1; pfam03400
316401006499	hypothetical protein; Validated; Region: PRK03657
316401006500	dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280
316401006501	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
316401006502	active site
316401006503	Zn binding site [ion binding]; other site
316401006504	PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.
316401006505	malonic semialdehyde reductase; Provisional; Region: PRK10538
316401006506	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
316401006507	putative NAD(P) binding site [chemical binding]; other site
316401006508	homodimer interface [polypeptide binding]; other site
316401006509	homotetramer interface [polypeptide binding]; other site
316401006510	active site
316401006511	PS00061 Short-chain dehydrogenases/reductases family signature.
316401006512	Transcriptional regulators [Transcription]; Region: GntR; COG1802
316401006513	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
316401006514	DNA-binding site [nucleotide binding]; DNA binding site
316401006515	FCD domain; Region: FCD; pfam07729
316401006516	PS00043 Bacterial regulatory proteins, gntR family signature.
316401006517	putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318
316401006518	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
316401006519	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
316401006520	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
316401006521	PS00974 Mannitol dehydrogenases signature.
316401006522	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401006523	metabolite-proton symporter; Region: 2A0106; TIGR00883
316401006524	putative substrate translocation pore; other site
316401006525	10 probable transmembrane helices predicted for ETEC1613 by TMHMM2.0 at aa 13-35, 55-77, 89-111, 159-181, 188-210, 282-301, 308-327, 337-359, 380-399 and 403-422
316401006526	putative oxidoreductase; Provisional; Region: PRK10083
316401006527	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
316401006528	putative NAD(P) binding site [chemical binding]; other site
316401006529	catalytic Zn binding site [ion binding]; other site
316401006530	structural Zn binding site [ion binding]; other site
316401006531	PS00059 Zinc-containing alcohol dehydrogenases signature.
316401006532	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
316401006533	The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322
316401006534	putative active site pocket [active]
316401006535	putative metal binding site [ion binding]; other site
316401006536	PS00909 Mandelate racemase / muconate lactonizing enzyme family signature 2.
316401006537	PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1.
316401006538	hypothetical protein; Provisional; Region: PRK02237
316401006539	4 probable transmembrane helices predicted for ETEC1616 by TMHMM2.0 at aa 7-26, 30-52, 59-78 and 88-106
316401006540	hypothetical protein; Provisional; Region: PRK13659
316401006541	Signal peptide predicted for ETEC1617 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 28 and 29
316401006542	spermidine N1-acetyltransferase; Provisional; Region: PRK15130
316401006543	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
316401006544	Coenzyme A binding pocket [chemical binding]; other site
316401006545	Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788
316401006546	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401006547	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
316401006548	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
316401006549	putative [Fe4-S4] binding site [ion binding]; other site
316401006550	putative molybdopterin cofactor binding site [chemical binding]; other site
316401006551	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
316401006552	putative molybdopterin cofactor binding site; other site
316401006553	Signal peptide predicted for ETEC1621 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.801 between residues 42 and 43
316401006554	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
316401006555	PS00932 Prokaryotic molybdopterin oxidoreductases signature 3.
316401006556	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
316401006557	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
316401006558	putative [Fe4-S4] binding site [ion binding]; other site
316401006559	putative molybdopterin cofactor binding site [chemical binding]; other site
316401006560	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
316401006561	putative molybdopterin cofactor binding site; other site
316401006562	Signal peptide predicted for ETEC1622 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 45 and 46
316401006563	PS00551 Prokaryotic molybdopterin oxidoreductases signature 1.
316401006564	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
316401006565	4Fe-4S binding domain; Region: Fer4; cl02805
316401006566	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401006567	PS00190 Cytochrome c family heme-binding site signature.
316401006568	twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621
316401006569	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
316401006570	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
316401006571	Cl- selectivity filter; other site
316401006572	Cl- binding residues [ion binding]; other site
316401006573	pore gating glutamate residue; other site
316401006574	dimer interface [polypeptide binding]; other site
316401006575	Signal peptide predicted for ETEC1626 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.806 between residues 25 and 26
316401006576	10 probable transmembrane helices predicted for ETEC1626 by TMHMM2.0 at aa 5-27, 54-71, 146-168, 178-200, 221-240, 260-282, 289-311, 321-343, 350-372 and 382-404
316401006577	putative dithiobiotin synthetase; Provisional; Region: PRK12374
316401006578	AAA domain; Region: AAA_26; pfam13500
316401006579	PS00017 ATP/GTP-binding site motif A (P-loop).
316401006580	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
316401006581	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
316401006582	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
316401006583	nucleotide binding site [chemical binding]; other site
316401006584	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
316401006585	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401006586	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
316401006587	dimerization interface [polypeptide binding]; other site
316401006588	substrate binding pocket [chemical binding]; other site
316401006589	PS00044 Bacterial regulatory proteins, lysR family signature.
316401006590	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
316401006591	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401006592	putative substrate translocation pore; other site
316401006593	12 probable transmembrane helices predicted for ETEC1630 by TMHMM2.0 at aa 37-59, 74-95, 102-124, 128-150, 157-179, 189-211, 240-262, 272-291, 304-323, 328-350, 363-385 and 389-411
316401006594	PS00216 Sugar transport proteins signature 1.
316401006595	Signal peptide predicted for ETEC1631 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 21 and 22
316401006596	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
316401006597	Signal peptide predicted for ETEC1632 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 21 and 22
316401006598	PS00134 Serine proteases, trypsin family, histidine active site.
316401006599	PS00135 Serine proteases, trypsin family, serine active site.
316401006600	multidrug efflux system protein MdtI; Provisional; Region: PRK10650
316401006601	4 probable transmembrane helices predicted for ETEC1633 by TMHMM2.0 at aa 10-29, 36-53, 63-85 and 92-106
316401006602	multidrug efflux system protein MdtJ; Provisional; Region: PRK10452
316401006603	4 probable transmembrane helices predicted for ETEC1634 by TMHMM2.0 at aa 2-20, 30-52, 57-79 and 83-102
316401006604	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287
316401006605	Domain of unknown function DUF20; Region: UPF0118; pfam01594
316401006606	Signal peptide predicted for ETEC1635 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.997 between residues 30 and 31
316401006607	8 probable transmembrane helices predicted for ETEC1635 by TMHMM2.0 at aa 7-29, 33-55, 62-84, 144-166, 196-218, 222-244, 257-279 and 299-321
316401006608	pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444
316401006609	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
316401006610	9 probable transmembrane helices predicted for ETEC1636 by TMHMM2.0 at aa 5-24, 33-52, 57-75, 88-107, 122-144, 164-181, 185-207, 214-236 and 240-259
316401006611	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
316401006612	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
316401006613	ligand binding site [chemical binding]; other site
316401006614	homodimer interface [polypeptide binding]; other site
316401006615	NAD(P) binding site [chemical binding]; other site
316401006616	trimer interface B [polypeptide binding]; other site
316401006617	trimer interface A [polypeptide binding]; other site
316401006618	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
316401006619	5 probable transmembrane helices predicted for ETEC1637 by TMHMM2.0 at aa 169-191, 403-420, 424-446, 453-472 and 477-499
316401006620	PS00837 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 2.
316401006621	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
316401006622	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
316401006623	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
316401006624	Signal peptide predicted for ETEC1638 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.994 between residues 22 and 23
316401006625	transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
316401006626	Spore germination protein; Region: Spore_permease; cl17796
316401006627	Signal peptide predicted for ETEC1639 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.401 between residues 31 and 32
316401006628	13 probable transmembrane helices predicted for ETEC1639 by TMHMM2.0 at aa 5-27, 37-59, 90-112, 127-149, 156-178, 203-222, 235-257, 277-299, 329-351, 356-378, 385-403, 407-426 and 442-459
316401006629	dihydromonapterin reductase; Provisional; Region: PRK06483
316401006630	pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357
316401006631	NADP binding site [chemical binding]; other site
316401006632	substrate binding pocket [chemical binding]; other site
316401006633	active site
316401006634	PS00061 Short-chain dehydrogenases/reductases family signature.
316401006635	Uncharacterized membrane protein required for alginate biosynthesis [General function prediction only]; Region: GlpM; COG3136
316401006636	4 probable transmembrane helices predicted for ETEC1641 by TMHMM2.0 at aa 4-21, 28-47, 57-79 and 86-108
316401006637	Signal peptide predicted for ETEC1641 by SignalP 2.0 HMM (Signal peptide probability 0.963) with cleavage site probability 0.936 between residues 21 and 22
316401006638	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
316401006639	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316401006640	active site
316401006641	phosphorylation site [posttranslational modification]
316401006642	intermolecular recognition site; other site
316401006643	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
316401006644	DNA binding site [nucleotide binding]
316401006645	sensor protein RstB; Provisional; Region: PRK10604
316401006646	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
316401006647	dimerization interface [polypeptide binding]; other site
316401006648	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316401006649	dimer interface [polypeptide binding]; other site
316401006650	phosphorylation site [posttranslational modification]
316401006651	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316401006652	ATP binding site [chemical binding]; other site
316401006653	Mg2+ binding site [ion binding]; other site
316401006654	G-X-G motif; other site
316401006655	Signal peptide predicted for ETEC1643 by SignalP 2.0 HMM (Signal peptide probability 0.958) with cleavage site probability 0.716 between residues 28 and 29
316401006656	2 probable transmembrane helices predicted for ETEC1643 by TMHMM2.0 at aa 5-27 and 139-156
316401006657	DNA replication terminus site-binding protein; Provisional; Region: PRK02951
316401006658	fumarate hydratase; Reviewed; Region: fumC; PRK00485
316401006659	Class II fumarases; Region: Fumarase_classII; cd01362
316401006660	active site
316401006661	tetramer interface [polypeptide binding]; other site
316401006662	PS00163 Fumarate lyases signature.
316401006663	fumarate hydratase; Provisional; Region: PRK15389
316401006664	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951
316401006665	Fumarase C-terminus; Region: Fumerase_C; pfam05683
316401006666	PS00163 Fumarate lyases signature.
316401006667	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
316401006668	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
316401006669	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
316401006670	PS00965 Phosphomannose isomerase type I signature 1.
316401006671	PS00966 Phosphomannose isomerase type I signature 2.
316401006672	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
316401006673	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
316401006674	Signal peptide predicted for ETEC1648 by SignalP 2.0 HMM (Signal peptide probability 0.853) with cleavage site probability 0.808 between residues 19 and 20
316401006675	1 probable transmembrane helix predicted for ETEC1648 by TMHMM2.0 at aa 5-24
316401006676	PS00017 ATP/GTP-binding site motif A (P-loop).
316401006677	putative outer membrane porin protein; Provisional; Region: PRK11379
316401006678	1 probable transmembrane helix predicted for ETEC1649 by TMHMM2.0 at aa 5-27
316401006679	Signal peptide predicted for ETEC1649 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.979 between residues 23 and 24
316401006680	glucuronide transporter; Provisional; Region: PRK09848
316401006681	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
316401006682	12 probable transmembrane helices predicted for ETEC1650 by TMHMM2.0 at aa 12-34, 38-60, 80-102, 112-134, 147-169, 179-201, 230-252, 262-284, 297-316, 321-343, 373-392 and 407-429
316401006683	PS00527 Ribosomal protein S14 signature.
316401006684	PS00872 Sodium:galactoside symporter family signature.
316401006685	beta-D-glucuronidase; Provisional; Region: PRK10150
316401006686	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
316401006687	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
316401006688	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
316401006689	PS00608 Glycosyl hydrolases family 2 acid/base catalyst.
316401006690	PS00719 Glycosyl hydrolases family 2 signature 1.
316401006691	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
316401006692	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
316401006693	PS01081 Bacterial regulatory proteins, tetR family signature.
316401006694	7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113
316401006695	7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365
316401006696	NAD binding site [chemical binding]; other site
316401006697	substrate binding site [chemical binding]; other site
316401006698	homotetramer interface [polypeptide binding]; other site
316401006699	homodimer interface [polypeptide binding]; other site
316401006700	active site
316401006701	PS00061 Short-chain dehydrogenases/reductases family signature.
316401006702	DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014
316401006703	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
316401006704	DNA binding site [nucleotide binding]
316401006705	domain linker motif; other site
316401006706	Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289
316401006707	putative dimerization interface [polypeptide binding]; other site
316401006708	putative ligand binding site [chemical binding]; other site
316401006709	PS00356 Bacterial regulatory proteins, lacI family signature.
316401006710	bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110
316401006711	PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852
316401006712	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
316401006713	active site turn [active]
316401006714	phosphorylation site [posttranslational modification]
316401006715	Signal peptide predicted for ETEC1655 by SignalP 2.0 HMM (Signal peptide probability 0.646) with cleavage site probability 0.554 between residues 44 and 45
316401006716	8 probable transmembrane helices predicted for ETEC1655 by TMHMM2.0 at aa 21-43, 69-88, 95-117, 139-161, 182-204, 325-347, 352-374 and 397-419
316401006717	PS00287 Cysteine proteases inhibitors signature.
316401006718	PS01035 PTS EIIB domains cysteine phosphorylation site signature.
316401006719	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
316401006720	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
316401006721	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316401006722	homodimer interface [polypeptide binding]; other site
316401006723	catalytic residue [active]
316401006724	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
316401006725	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
316401006726	active site
316401006727	purine riboside binding site [chemical binding]; other site
316401006728	PS00485 Adenosine and AMP deaminase signature.
316401006729	putative oxidoreductase; Provisional; Region: PRK11579
316401006730	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
316401006731	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
316401006732	1 probable transmembrane helix predicted for ETEC1659 by TMHMM2.0 at aa 7-26
316401006733	oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391
316401006734	Protein of unknown function (DUF2569); Region: DUF2569; pfam10754
316401006735	Signal peptide predicted for ETEC1661 by SignalP 2.0 HMM (Signal peptide probability 0.980) with cleavage site probability 0.854 between residues 39 and 40
316401006736	4 probable transmembrane helices predicted for ETEC1661 by TMHMM2.0 at aa 13-35, 55-77, 90-109 and 114-133
316401006737	electron transport complex protein RsxA; Provisional; Region: PRK05151
316401006738	6 probable transmembrane helices predicted for ETEC1662 by TMHMM2.0 at aa 5-27, 37-59, 66-88, 103-125, 132-154 and 169-191
316401006739	electron transport complex protein RnfB; Provisional; Region: PRK05113
316401006740	Putative Fe-S cluster; Region: FeS; pfam04060
316401006741	4Fe-4S binding domain; Region: Fer4; pfam00037
316401006742	Signal peptide predicted for ETEC1663 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.831 between residues 30 and 31
316401006743	1 probable transmembrane helix predicted for ETEC1663 by TMHMM2.0 at aa 4-26
316401006744	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401006745	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401006746	Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656
316401006747	SLBB domain; Region: SLBB; pfam10531
316401006748	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
316401006749	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401006750	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401006751	electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816
316401006752	Signal peptide predicted for ETEC1665 by SignalP 2.0 HMM (Signal peptide probability 0.955) with cleavage site probability 0.829 between residues 33 and 34
316401006753	10 probable transmembrane helices predicted for ETEC1665 by TMHMM2.0 at aa 20-39, 43-65, 78-109, 124-143, 148-170, 214-236, 243-262, 272-294, 301-318 and 323-342
316401006754	electron transport complex protein RnfG; Validated; Region: PRK01908
316401006755	Signal peptide predicted for ETEC1666 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.974 between residues 24 and 25
316401006756	electron transport complex RsxE subunit; Provisional; Region: PRK12405
316401006757	5 probable transmembrane helices predicted for ETEC1667 by TMHMM2.0 at aa 34-56, 69-87, 91-113, 126-148 and 183-205
316401006758	endonuclease III; Provisional; Region: PRK10702
316401006759	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
316401006760	minor groove reading motif; other site
316401006761	helix-hairpin-helix signature motif; other site
316401006762	substrate binding pocket [chemical binding]; other site
316401006763	active site
316401006764	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
316401006765	PS01155 Endonuclease III family signature.
316401006766	PS00764 Endonuclease III iron-sulfur binding region signature.
316401006767	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
316401006768	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401006769	putative substrate translocation pore; other site
316401006770	POT family; Region: PTR2; pfam00854
316401006771	14 probable transmembrane helices predicted for ETEC1669 by TMHMM2.0 at aa 22-44, 59-81, 90-107, 112-129, 150-172, 177-199, 220-239, 244-266, 275-292, 323-340, 353-375, 385-407, 419-441 and 456-478
316401006772	PS01022 PTR2 family proton/oligopeptide symporters signature 1.
316401006773	PS00778 Histidine acid phosphatases active site signature.
316401006774	PS01023 PTR2 family proton/oligopeptide symporters signature 2.
316401006775	glutathionine S-transferase; Provisional; Region: PRK10542
316401006776	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
316401006777	C-terminal domain interface [polypeptide binding]; other site
316401006778	GSH binding site (G-site) [chemical binding]; other site
316401006779	dimer interface [polypeptide binding]; other site
316401006780	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
316401006781	N-terminal domain interface [polypeptide binding]; other site
316401006782	dimer interface [polypeptide binding]; other site
316401006783	substrate binding pocket (H-site) [chemical binding]; other site
316401006784	pyridoxamine kinase; Validated; Region: PRK05756
316401006785	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
316401006786	dimer interface [polypeptide binding]; other site
316401006787	pyridoxal binding site [chemical binding]; other site
316401006788	ATP binding site [chemical binding]; other site
316401006789	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
316401006790	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
316401006791	active site
316401006792	HIGH motif; other site
316401006793	dimer interface [polypeptide binding]; other site
316401006794	KMSKS motif; other site
316401006795	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
316401006796	RNA binding surface [nucleotide binding]; other site
316401006797	PS00178 Aminoacyl-transfer RNA synthetases class-I signature.
316401006798	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
316401006799	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
316401006800	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
316401006801	PS01064 Pyridoxamine 5'-phosphate oxidase signature.
316401006802	lysozyme inhibitor; Provisional; Region: PRK11372
316401006803	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
316401006804	Signal peptide predicted for ETEC1674 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.637 between residues 22 and 23
316401006805	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401006806	Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702
316401006807	Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133
316401006808	Signal peptide predicted for ETEC1676 by SignalP 2.0 HMM (Signal peptide probability 0.856) with cleavage site probability 0.682 between residues 21 and 22
316401006809	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401006810	transcriptional regulator SlyA; Provisional; Region: PRK03573
316401006811	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
316401006812	PS01117 Bacterial regulatory proteins, marR family signature.
316401006813	Protein of unknown function (DUF1656); Region: DUF1656; cl11658
316401006814	2 probable transmembrane helices predicted for ETEC1678 by TMHMM2.0 at aa 15-40 and 53-75
316401006815	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
316401006816	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
316401006817	HlyD family secretion protein; Region: HlyD_3; pfam13437
316401006818	Signal peptide predicted for ETEC1679 by SignalP 2.0 HMM (Signal peptide probability 0.785) with cleavage site probability 0.743 between residues 21 and 22
316401006819	1 probable transmembrane helix predicted for ETEC1679 by TMHMM2.0 at aa 7-26
316401006820	Fusaric acid resistance protein family; Region: FUSC; pfam04632
316401006821	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
316401006822	10 probable transmembrane helices predicted for ETEC1680 by TMHMM2.0 at aa 23-42, 47-69, 76-98, 118-140, 153-170, 381-403, 410-432, 437-454, 461-483 and 493-510
316401006823	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
316401006824	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
316401006825	E-class dimer interface [polypeptide binding]; other site
316401006826	P-class dimer interface [polypeptide binding]; other site
316401006827	active site
316401006828	Cu2+ binding site [ion binding]; other site
316401006829	Zn2+ binding site [ion binding]; other site
316401006830	PS00332 Copper/Zinc superoxide dismutase signature 2.
316401006831	Signal peptide predicted for ETEC1681 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.986 between residues 19 and 20
316401006832	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
316401006833	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
316401006834	active site
316401006835	catalytic tetrad [active]
316401006836	Predicted Fe-S protein [General function prediction only]; Region: COG3313
316401006837	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
316401006838	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
316401006839	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
316401006840	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
316401006841	FMN binding site [chemical binding]; other site
316401006842	active site
316401006843	substrate binding site [chemical binding]; other site
316401006844	catalytic residue [active]
316401006845	PS00030 Eukaryotic putative RNA-binding region RNP-1 signature.
316401006846	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
316401006847	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
316401006848	dimer interface [polypeptide binding]; other site
316401006849	active site
316401006850	metal binding site [ion binding]; metal-binding site
316401006851	glutathione binding site [chemical binding]; other site
316401006852	PS00934 Glyoxalase I signature 1.
316401006853	PS00935 Glyoxalase I signature 2.
316401006854	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
316401006855	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
316401006856	dimer interface [polypeptide binding]; other site
316401006857	catalytic site [active]
316401006858	putative active site [active]
316401006859	putative substrate binding site [chemical binding]; other site
316401006860	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
316401006861	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
316401006862	ATP binding site [chemical binding]; other site
316401006863	putative Mg++ binding site [ion binding]; other site
316401006864	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
316401006865	nucleotide binding region [chemical binding]; other site
316401006866	ATP-binding site [chemical binding]; other site
316401006867	DEAD/H associated; Region: DEAD_assoc; pfam08494
316401006868	PS00017 ATP/GTP-binding site motif A (P-loop).
316401006869	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
316401006870	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
316401006871	putative GSH binding site [chemical binding]; other site
316401006872	catalytic residues [active]
316401006873	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
316401006874	NlpC/P60 family; Region: NLPC_P60; pfam00877
316401006875	Signal peptide predicted for ETEC1690 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.892 between residues 27 and 28
316401006876	superoxide dismutase; Provisional; Region: PRK10543
316401006877	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
316401006878	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
316401006879	PS00017 ATP/GTP-binding site motif A (P-loop).
316401006880	PS00088 Manganese and iron superoxide dismutases signature.
316401006881	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401006882	Major Facilitator Superfamily; Region: MFS_1; pfam07690
316401006883	putative substrate translocation pore; other site
316401006884	12 probable transmembrane helices predicted for ETEC1692 by TMHMM2.0 at aa 5-27, 42-64, 71-90, 100-122, 129-151, 156-178, 203-225, 235-257, 264-286, 291-313, 326-348 and 352-374
316401006885	DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703
316401006886	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
316401006887	DNA binding site [nucleotide binding]
316401006888	domain linker motif; other site
316401006889	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
316401006890	dimerization interface [polypeptide binding]; other site
316401006891	ligand binding site [chemical binding]; other site
316401006892	PS00356 Bacterial regulatory proteins, lacI family signature.
316401006893	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
316401006894	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401006895	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
316401006896	dimerization interface [polypeptide binding]; other site
316401006897	PS00044 Bacterial regulatory proteins, lysR family signature.
316401006898	putative transporter; Provisional; Region: PRK11043
316401006899	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401006900	putative substrate translocation pore; other site
316401006901	Signal peptide predicted for ETEC1695 by SignalP 2.0 HMM (Signal peptide probability 0.986) with cleavage site probability 0.976 between residues 30 and 31
316401006902	12 probable transmembrane helices predicted for ETEC1695 by TMHMM2.0 at aa 7-29, 39-61, 73-92, 97-119, 131-153, 158-180, 208-230, 235-257, 270-292, 296-318, 339-357 and 361-380
316401006903	cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705
316401006904	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
316401006905	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316401006906	S-adenosylmethionine binding site [chemical binding]; other site
316401006907	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
316401006908	Lumazine binding domain; Region: Lum_binding; pfam00677
316401006909	Lumazine binding domain; Region: Lum_binding; pfam00677
316401006910	PS00693 Riboflavin synthase alpha chain family signature.
316401006911	PS00693 Riboflavin synthase alpha chain family signature.
316401006912	multidrug efflux protein; Reviewed; Region: PRK01766
316401006913	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
316401006914	cation binding site [ion binding]; other site
316401006915	Signal peptide predicted for ETEC1698 by SignalP 2.0 HMM (Signal peptide probability 0.929) with cleavage site probability 0.437 between residues 29 and 30
316401006916	12 probable transmembrane helices predicted for ETEC1698 by TMHMM2.0 at aa 7-29, 44-66, 91-113, 128-147, 160-180, 190-212, 241-263, 278-300, 313-335, 350-367, 387-409 and 419-438
316401006917	hypothetical protein; Provisional; Region: PRK09945
316401006918	Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468
316401006919	putative monooxygenase; Provisional; Region: PRK11118
316401006920	hypothetical protein; Provisional; Region: PRK09897
316401006921	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
316401006922	PS00215 Mitochondrial energy transfer proteins signature.
316401006923	hypothetical protein; Provisional; Region: PRK09946
316401006924	thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006
316401006925	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
316401006926	5 probable transmembrane helices predicted for ETEC1703 by TMHMM2.0 at aa 28-50, 75-97, 107-129, 182-204 and 219-241
316401006927	cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149
316401006928	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401006929	1 probable transmembrane helix predicted for ETEC1704 by TMHMM2.0 at aa 7-29
316401006930	Signal peptide predicted for ETEC1704 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.920 between residues 27 and 28
316401006931	hypothetical protein; Provisional; Region: PRK09947
316401006932	putative oxidoreductase; Provisional; Region: PRK09849
316401006933	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
316401006934	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
316401006935	hypothetical protein; Provisional; Region: PRK09898
316401006936	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
316401006937	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401006938	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401006939	PS00190 Cytochrome c family heme-binding site signature.
316401006940	hypothetical protein; Provisional; Region: PRK10292
316401006941	pyruvate kinase; Provisional; Region: PRK09206
316401006942	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
316401006943	domain interfaces; other site
316401006944	active site
316401006945	PS00110 Pyruvate kinase active site signature.
316401006946	murein lipoprotein; Provisional; Region: PRK15396
316401006947	Signal peptide predicted for ETEC1710 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.969 between residues 25 and 26
316401006948	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401006949	L,D-transpeptidase; Provisional; Region: PRK10190
316401006950	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
316401006951	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
316401006952	PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide.
316401006953	Signal peptide predicted for ETEC1711 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.951 between residues 23 and 24
316401006954	cysteine desufuration protein SufE; Provisional; Region: PRK09296
316401006955	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
316401006956	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
316401006957	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
316401006958	catalytic residue [active]
316401006959	PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site.
316401006960	cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948
316401006961	FeS assembly protein SufD; Region: sufD; TIGR01981
316401006962	cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580
316401006963	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
316401006964	Walker A/P-loop; other site
316401006965	ATP binding site [chemical binding]; other site
316401006966	Q-loop/lid; other site
316401006967	ABC transporter signature motif; other site
316401006968	Walker B; other site
316401006969	D-loop; other site
316401006970	H-loop/switch region; other site
316401006971	PS00211 ABC transporters family signature.
316401006972	PS00017 ATP/GTP-binding site motif A (P-loop).
316401006973	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
316401006974	putative ABC transporter; Region: ycf24; CHL00085
316401006975	iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504
316401006976	PS01152 Hypothetical hesB/yadR/yfhF family signature.
316401006977	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
316401006978	CoenzymeA binding site [chemical binding]; other site
316401006979	subunit interaction site [polypeptide binding]; other site
316401006980	PHB binding site; other site
316401006981	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
316401006982	FAD binding domain; Region: FAD_binding_4; pfam01565
316401006983	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
316401006984	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401006985	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
316401006986	PS00017 ATP/GTP-binding site motif A (P-loop).
316401006987	putative inner membrane protein; Provisional; Region: PRK10983
316401006988	Domain of unknown function DUF20; Region: UPF0118; pfam01594
316401006989	Signal peptide predicted for ETEC1721 by SignalP 2.0 HMM (Signal peptide probability 0.641) with cleavage site probability 0.633 between residues 41 and 42
316401006990	9 probable transmembrane helices predicted for ETEC1721 by TMHMM2.0 at aa 13-32, 36-53, 65-87, 159-181, 202-224, 228-250, 252-271, 276-295 and 308-330
316401006991	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401006992	Domain of unknown function (DUF1870); Region: DUF1870; pfam08965
316401006993	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401006994	Major Facilitator Superfamily; Region: MFS_1; pfam07690
316401006995	putative substrate translocation pore; other site
316401006996	12 probable transmembrane helices predicted for ETEC1723 by TMHMM2.0 at aa 12-34, 44-66, 73-90, 95-112, 133-155, 159-181, 210-232, 242-264, 277-299, 303-325, 338-355 and 365-382
316401006997	PS00216 Sugar transport proteins signature 1.
316401006998	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401006999	putative substrate translocation pore; other site
316401007000	Signal peptide predicted for ETEC1724 by SignalP 2.0 HMM (Signal peptide probability 0.737) with cleavage site probability 0.640 between residues 33 and 34
316401007001	12 probable transmembrane helices predicted for ETEC1724 by TMHMM2.0 at aa 12-34, 49-71, 78-97, 101-118, 138-160, 164-186, 212-234, 254-273, 280-299, 309-328, 340-362 and 367-389
316401007002	quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749
316401007003	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
316401007004	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
316401007005	shikimate binding site; other site
316401007006	NAD(P) binding site [chemical binding]; other site
316401007007	PS00017 ATP/GTP-binding site motif A (P-loop).
316401007008	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
316401007009	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
316401007010	active site
316401007011	catalytic residue [active]
316401007012	dimer interface [polypeptide binding]; other site
316401007013	PS01028 Dehydroquinase class I active site.
316401007014	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
316401007015	Coenzyme A transferase; Region: CoA_trans; smart00882
316401007016	Coenzyme A transferase; Region: CoA_trans; cl17247
316401007017	putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341
316401007018	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
316401007019	active site
316401007020	PS00072 Acyl-CoA dehydrogenases signature 1.
316401007021	PS00073 Acyl-CoA dehydrogenases signature 2.
316401007022	Cupin domain; Region: Cupin_2; pfam07883
316401007023	Winged helix DNA-binding domain (DUF1495); Region: DUF1495; cl01336
316401007024	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
316401007025	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316401007026	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
316401007027	Ligand binding site [chemical binding]; other site
316401007028	Electron transfer flavoprotein domain; Region: ETF; pfam01012
316401007029	PS01065 Electron transfer flavoprotein beta-subunit signature.
316401007030	electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916
316401007031	Electron transfer flavoprotein domain; Region: ETF; smart00893
316401007032	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
316401007033	PS00696 Electron transfer flavoprotein alpha-subunit signature.
316401007034	oxidoreductase; Provisional; Region: PRK10015
316401007035	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
316401007036	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401007037	short chain acyl-CoA synthetase; Reviewed; Region: PRK06087
316401007038	Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903
316401007039	acyl-activating enzyme (AAE) consensus motif; other site
316401007040	putative AMP binding site [chemical binding]; other site
316401007041	putative active site [active]
316401007042	putative CoA binding site [chemical binding]; other site
316401007043	PS00455 Putative AMP-binding domain signature.
316401007044	phosphoenolpyruvate synthase; Validated; Region: PRK06464
316401007045	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
316401007046	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
316401007047	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
316401007048	PS00742 PEP-utilizing enzymes signature 2.
316401007049	PS00370 PEP-utilizing enzymes phosphorylation site signature.
316401007050	PEP synthetase regulatory protein; Provisional; Region: PRK05339
316401007051	PS00017 ATP/GTP-binding site motif A (P-loop).
316401007052	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756
316401007053	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
316401007054	Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256
316401007055	Uncharacterized conserved protein [Function unknown]; Region: COG0397
316401007056	hypothetical protein; Validated; Region: PRK00029
316401007057	This CDS possesses an internal stop codon
316401007058	NlpC/P60 family; Region: NLPC_P60; pfam00877
316401007059	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401007060	vitamin B12-transporter ATPase; Provisional; Region: PRK03695
316401007061	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
316401007062	Walker A/P-loop; other site
316401007063	ATP binding site [chemical binding]; other site
316401007064	Q-loop/lid; other site
316401007065	ABC transporter signature motif; other site
316401007066	Walker B; other site
316401007067	D-loop; other site
316401007068	H-loop/switch region; other site
316401007069	PS00211 ABC transporters family signature.
316401007070	PS00017 ATP/GTP-binding site motif A (P-loop).
316401007071	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
316401007072	catalytic residues [active]
316401007073	dimer interface [polypeptide binding]; other site
316401007074	PS00763 Glutathione peroxidases signature 2.
316401007075	PS00460 Glutathione peroxidases selenocysteine active site.
316401007076	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
316401007077	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
316401007078	ABC-ATPase subunit  interface; other site
316401007079	dimer interface [polypeptide binding]; other site
316401007080	putative PBP binding regions; other site
316401007081	9 probable transmembrane helices predicted for ETEC1744 by TMHMM2.0 at aa 13-35, 55-77, 90-107, 111-133, 146-168, 188-205, 242-264, 274-296 and 303-322
316401007082	Signal peptide predicted for ETEC1744 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.934 between residues 33 and 34
316401007083	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
316401007084	IHF dimer interface [polypeptide binding]; other site
316401007085	IHF - DNA interface [nucleotide binding]; other site
316401007086	PS00045 Bacterial histone-like DNA-binding proteins signature.
316401007087	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
316401007088	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
316401007089	putative tRNA-binding site [nucleotide binding]; other site
316401007090	B3/4 domain; Region: B3_4; pfam03483
316401007091	tRNA synthetase B5 domain; Region: B5; smart00874
316401007092	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
316401007093	dimer interface [polypeptide binding]; other site
316401007094	motif 1; other site
316401007095	motif 3; other site
316401007096	motif 2; other site
316401007097	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
316401007098	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
316401007099	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
316401007100	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
316401007101	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
316401007102	dimer interface [polypeptide binding]; other site
316401007103	motif 1; other site
316401007104	active site
316401007105	motif 2; other site
316401007106	motif 3; other site
316401007107	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
316401007108	PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1.
316401007109	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
316401007110	23S rRNA binding site [nucleotide binding]; other site
316401007111	L21 binding site [polypeptide binding]; other site
316401007112	L13 binding site [polypeptide binding]; other site
316401007113	PS00937 Ribosomal protein L20 signature.
316401007114	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
316401007115	PS00936 Ribosomal protein L35 signature.
316401007116	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
316401007117	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
316401007118	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
316401007119	PS00938 Initiation factor 3 signature.
316401007120	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
316401007121	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
316401007122	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
316401007123	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
316401007124	active site
316401007125	dimer interface [polypeptide binding]; other site
316401007126	motif 1; other site
316401007127	motif 2; other site
316401007128	motif 3; other site
316401007129	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
316401007130	anticodon binding site; other site
316401007131	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
316401007132	PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1.
316401007133	Similar to Escherichia coli ArpB ankyrin repeat protein b. UniProt:P76205 (632 aa) fasta scores: E()=0, 98.418% id in 632 aa
316401007134	1 probable transmembrane helix predicted for ETEC1753 by TMHMM2.0 at aa 48-67
316401007135	Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137
316401007136	Signal peptide predicted for ETEC1754 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.922 between residues 25 and 26
316401007137	6-phosphofructokinase 2; Provisional; Region: PRK10294
316401007138	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
316401007139	putative substrate binding site [chemical binding]; other site
316401007140	putative ATP binding site [chemical binding]; other site
316401007141	PS00583 pfkB family of carbohydrate kinases signature 1.
316401007142	PS00584 pfkB family of carbohydrate kinases signature 2.
316401007143	Protein of unknown function (DUF2622); Region: DUF2622; pfam11080
316401007144	Phosphotransferase enzyme family; Region: APH; pfam01636
316401007145	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
316401007146	active site
316401007147	ATP binding site [chemical binding]; other site
316401007148	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
316401007149	YniB-like protein; Region: YniB; pfam14002
316401007150	3 probable transmembrane helices predicted for ETEC1758 by TMHMM2.0 at aa 15-33, 79-101 and 155-177
316401007151	2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826
316401007152	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
316401007153	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
316401007154	motif II; other site
316401007155	inner membrane protein; Provisional; Region: PRK11648
316401007156	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
316401007157	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
316401007158	Signal peptide predicted for ETEC1761 by SignalP 2.0 HMM (Signal peptide probability 0.921) with cleavage site probability 0.748 between residues 20 and 21
316401007159	9 probable transmembrane helices predicted for ETEC1761 by TMHMM2.0 at aa 5-20, 33-51, 71-93, 105-127, 180-202, 260-282, 340-362, 369-391 and 395-417
316401007160	cell division modulator; Provisional; Region: PRK10113
316401007161	hydroperoxidase II; Provisional; Region: katE; PRK11249
316401007162	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
316401007163	tetramer interface [polypeptide binding]; other site
316401007164	heme binding pocket [chemical binding]; other site
316401007165	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
316401007166	domain interactions; other site
316401007167	PS00438 Catalase proximal active site signature.
316401007168	PS00437 Catalase proximal heme-ligand signature.
316401007169	Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803
316401007170	putative active site [active]
316401007171	YdjC motif; other site
316401007172	Mg binding site [ion binding]; other site
316401007173	putative homodimer interface [polypeptide binding]; other site
316401007174	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
316401007175	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
316401007176	NAD binding site [chemical binding]; other site
316401007177	sugar binding site [chemical binding]; other site
316401007178	divalent metal binding site [ion binding]; other site
316401007179	tetramer (dimer of dimers) interface [polypeptide binding]; other site
316401007180	dimer interface [polypeptide binding]; other site
316401007181	PS01324 Glycosyl hydrolases family 4 signature.
316401007182	DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296
316401007183	Cupin domain; Region: Cupin_2; pfam07883
316401007184	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316401007185	PS00041 Bacterial regulatory proteins, araC family signature.
316401007186	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
316401007187	methionine cluster; other site
316401007188	active site
316401007189	phosphorylation site [posttranslational modification]
316401007190	metal binding site [ion binding]; metal-binding site
316401007191	PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297
316401007192	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
316401007193	10 probable transmembrane helices predicted for ETEC1769 by TMHMM2.0 at aa 31-53, 85-107, 114-133, 143-165, 186-208, 232-254, 298-320, 345-364, 371-393 and 408-430
316401007194	PS00017 ATP/GTP-binding site motif A (P-loop).
316401007195	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
316401007196	active site
316401007197	P-loop; other site
316401007198	phosphorylation site [posttranslational modification]
316401007199	Signal peptide predicted for ETEC1770 by SignalP 2.0 HMM (Signal peptide probability 0.688) with cleavage site probability 0.538 between residues 27 and 28
316401007200	DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251
316401007201	1 probable transmembrane helix predicted for ETEC1771 by TMHMM2.0 at aa 5-24
316401007202	Signal peptide predicted for ETEC1771 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.983 between residues 23 and 24
316401007203	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401007204	NAD+ synthetase; Region: nadE; TIGR00552
316401007205	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
316401007206	homodimer interface [polypeptide binding]; other site
316401007207	NAD binding pocket [chemical binding]; other site
316401007208	ATP binding pocket [chemical binding]; other site
316401007209	Mg binding site [ion binding]; other site
316401007210	active-site loop [active]
316401007211	nucleotide excision repair endonuclease; Provisional; Region: PRK10545
316401007212	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
316401007213	GIY-YIG motif/motif A; other site
316401007214	active site
316401007215	catalytic site [active]
316401007216	putative DNA binding site [nucleotide binding]; other site
316401007217	metal binding site [ion binding]; metal-binding site
316401007218	hypothetical protein; Provisional; Region: PRK11396
316401007219	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
316401007220	dimer interface [polypeptide binding]; other site
316401007221	Signal peptide predicted for ETEC1775 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 23 and 24
316401007222	Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855
316401007223	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
316401007224	putative active site [active]
316401007225	Zn binding site [ion binding]; other site
316401007226	succinylarginine dihydrolase; Provisional; Region: PRK13281
316401007227	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
316401007228	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
316401007229	NAD(P) binding site [chemical binding]; other site
316401007230	catalytic residues [active]
316401007231	PS00070 Aldehyde dehydrogenases cysteine active site.
316401007232	PS00687 Aldehyde dehydrogenases glutamic acid active site.
316401007233	arginine succinyltransferase; Provisional; Region: PRK10456
316401007234	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
316401007235	bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381
316401007236	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
316401007237	inhibitor-cofactor binding pocket; inhibition site
316401007238	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316401007239	catalytic residue [active]
316401007240	PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site.
316401007241	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
316401007242	putative catalytic site [active]
316401007243	putative phosphate binding site [ion binding]; other site
316401007244	active site
316401007245	metal binding site A [ion binding]; metal-binding site
316401007246	DNA binding site [nucleotide binding]
316401007247	putative AP binding site [nucleotide binding]; other site
316401007248	putative metal binding site B [ion binding]; other site
316401007249	PS00726 AP endonucleases family 1 signature 1.
316401007250	PS00727 AP endonucleases family 1 signature 2.
316401007251	PS00728 AP endonucleases family 1 signature 3.
316401007252	Uncharacterized conserved protein [Function unknown]; Region: COG0398
316401007253	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
316401007254	Signal peptide predicted for ETEC1782 by SignalP 2.0 HMM (Signal peptide probability 0.658) with cleavage site probability 0.354 between residues 23 and 24
316401007255	5 probable transmembrane helices predicted for ETEC1782 by TMHMM2.0 at aa 7-29, 44-63, 70-92, 153-175 and 188-210
316401007256	Signal peptide predicted for ETEC1783 by SignalP 2.0 HMM (Signal peptide probability 0.987) with cleavage site probability 0.680 between residues 26 and 27
316401007257	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401007258	Uncharacterized conserved protein [Function unknown]; Region: COG0398
316401007259	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
316401007260	Signal peptide predicted for ETEC1784 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.884 between residues 28 and 29
316401007261	5 probable transmembrane helices predicted for ETEC1784 by TMHMM2.0 at aa 15-37, 58-80, 95-117, 174-196 and 201-223
316401007262	Uncharacterized conserved protein [Function unknown]; Region: COG2128
316401007263	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
316401007264	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134
316401007265	hypothetical protein; Provisional; Region: PRK11622
316401007266	Signal peptide predicted for ETEC1786 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 21 and 22
316401007267	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135
316401007268	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401007269	dimer interface [polypeptide binding]; other site
316401007270	conserved gate region; other site
316401007271	putative PBP binding loops; other site
316401007272	ABC-ATPase subunit interface; other site
316401007273	Signal peptide predicted for ETEC1787 by SignalP 2.0 HMM (Signal peptide probability 0.645) with cleavage site probability 0.367 between residues 31 and 32
316401007274	12 probable transmembrane helices predicted for ETEC1787 by TMHMM2.0 at aa 2-24, 44-66, 79-101, 116-138, 165-187, 223-245, 268-290, 300-322, 331-353, 363-380, 412-434 and 468-490
316401007275	PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide.
316401007276	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136
316401007277	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316401007278	Walker A/P-loop; other site
316401007279	ATP binding site [chemical binding]; other site
316401007280	Q-loop/lid; other site
316401007281	ABC transporter signature motif; other site
316401007282	Walker B; other site
316401007283	D-loop; other site
316401007284	H-loop/switch region; other site
316401007285	Rhodanese Homology Domain; Region: RHOD; smart00450
316401007286	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
316401007287	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
316401007288	active site residue [active]
316401007289	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
316401007290	active site residue [active]
316401007291	Signal peptide predicted for ETEC1789 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 23 and 24
316401007292	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401007293	PS00380 Rhodanese signature 1.
316401007294	PS00683 Rhodanese C-terminal signature.
316401007295	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
316401007296	5 probable transmembrane helices predicted for ETEC1790 by TMHMM2.0 at aa 38-60, 80-102, 112-134, 147-169 and 174-196
316401007297	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
316401007298	active site
316401007299	8-oxo-dGMP binding site [chemical binding]; other site
316401007300	nudix motif; other site
316401007301	metal binding site [ion binding]; metal-binding site
316401007302	PS00893 mutT domain signature.
316401007303	Protein of unknown function (DUF1496); Region: DUF1496; pfam07383
316401007304	Signal peptide predicted for ETEC1792 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.982 between residues 18 and 19
316401007305	glutamate dehydrogenase; Provisional; Region: PRK09414
316401007306	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
316401007307	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
316401007308	NAD(P) binding site [chemical binding]; other site
316401007309	PS00074 Glu / Leu / Phe / Val dehydrogenases active site.
316401007310	hypothetical protein; Provisional; Region: PRK11380
316401007311	PS00017 ATP/GTP-binding site motif A (P-loop).
316401007312	2 probable transmembrane helices predicted for ETEC1794 by TMHMM2.0 at aa 37-59 and 69-91
316401007313	DNA topoisomerase III; Provisional; Region: PRK07726
316401007314	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
316401007315	active site
316401007316	putative interdomain interaction site [polypeptide binding]; other site
316401007317	putative metal-binding site [ion binding]; other site
316401007318	putative nucleotide binding site [chemical binding]; other site
316401007319	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
316401007320	domain I; other site
316401007321	DNA binding groove [nucleotide binding]
316401007322	phosphate binding site [ion binding]; other site
316401007323	domain II; other site
316401007324	domain III; other site
316401007325	nucleotide binding site [chemical binding]; other site
316401007326	catalytic site [active]
316401007327	domain IV; other site
316401007328	PS00396 Prokaryotic DNA topoisomerase I active site.
316401007329	selenophosphate synthetase; Provisional; Region: PRK00943
316401007330	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
316401007331	dimerization interface [polypeptide binding]; other site
316401007332	putative ATP binding site [chemical binding]; other site
316401007333	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401007334	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
316401007335	putative FMN binding site [chemical binding]; other site
316401007336	protease 4; Provisional; Region: PRK10949
316401007337	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
316401007338	tandem repeat interface [polypeptide binding]; other site
316401007339	oligomer interface [polypeptide binding]; other site
316401007340	active site residues [active]
316401007341	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019
316401007342	tandem repeat interface [polypeptide binding]; other site
316401007343	oligomer interface [polypeptide binding]; other site
316401007344	active site residues [active]
316401007345	1 probable transmembrane helix predicted for ETEC1798 by TMHMM2.0 at aa 21-43
316401007346	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
316401007347	active site
316401007348	homodimer interface [polypeptide binding]; other site
316401007349	PS00144 Asparaginase / glutaminase active site signature 1.
316401007350	PS00917 Asparaginase / glutaminase active site signature 2.
316401007351	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
316401007352	Isochorismatase family; Region: Isochorismatase; pfam00857
316401007353	catalytic triad [active]
316401007354	metal binding site [ion binding]; metal-binding site
316401007355	conserved cis-peptide bond; other site
316401007356	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
316401007357	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401007358	putative substrate translocation pore; other site
316401007359	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401007360	12 probable transmembrane helices predicted for ETEC1801 by TMHMM2.0 at aa 21-43, 58-80, 92-114, 118-140, 153-175, 179-198, 266-288, 298-320, 327-344, 354-376, 389-411 and 416-438
316401007361	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
316401007362	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
316401007363	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
316401007364	PS00894 Bacterial regulatory proteins, deoR family signature.
316401007365	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
316401007366	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
316401007367	active site
316401007368	catalytic tetrad [active]
316401007369	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
316401007370	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
316401007371	substrate binding site [chemical binding]; other site
316401007372	ATP binding site [chemical binding]; other site
316401007373	PS00584 pfkB family of carbohydrate kinases signature 2.
316401007374	PS00583 pfkB family of carbohydrate kinases signature 1.
316401007375	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
316401007376	intersubunit interface [polypeptide binding]; other site
316401007377	active site
316401007378	zinc binding site [ion binding]; other site
316401007379	Na+ binding site [ion binding]; other site
316401007380	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
316401007381	Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285
316401007382	inhibitor binding site; inhibition site
316401007383	catalytic Zn binding site [ion binding]; other site
316401007384	structural Zn binding site [ion binding]; other site
316401007385	NADP binding site [chemical binding]; other site
316401007386	tetramer interface [polypeptide binding]; other site
316401007387	PS00693 Riboflavin synthase alpha chain family signature.
316401007388	PS00059 Zinc-containing alcohol dehydrogenases signature.
316401007389	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401007390	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401007391	12 probable transmembrane helices predicted for ETEC1807 by TMHMM2.0 at aa 25-47, 59-81, 91-108, 115-137, 152-174, 181-203, 266-288, 301-323, 330-347, 354-376, 391-413 and 420-442
316401007392	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
316401007393	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258
316401007394	putative NAD(P) binding site [chemical binding]; other site
316401007395	catalytic Zn binding site [ion binding]; other site
316401007396	structural Zn binding site [ion binding]; other site
316401007397	PS00059 Zinc-containing alcohol dehydrogenases signature.
316401007398	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139
316401007399	methionine sulfoxide reductase B; Provisional; Region: PRK00222
316401007400	SelR domain; Region: SelR; pfam01641
316401007401	glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425
316401007402	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
316401007403	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
316401007404	PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site.
316401007405	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
316401007406	active site
316401007407	phosphate binding residues; other site
316401007408	catalytic residues [active]
316401007409	PS00017 ATP/GTP-binding site motif A (P-loop).
316401007410	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
316401007411	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
316401007412	active site
316401007413	catalytic tetrad [active]
316401007414	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
316401007415	Signal peptide predicted for ETEC1814 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 22 and 23
316401007416	PrkA family serine protein kinase; Provisional; Region: PRK15455
316401007417	AAA ATPase domain; Region: AAA_16; pfam13191
316401007418	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
316401007419	PS00017 ATP/GTP-binding site motif A (P-loop).
316401007420	hypothetical protein; Provisional; Region: PRK05325
316401007421	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
316401007422	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316401007423	metal binding site [ion binding]; metal-binding site
316401007424	active site
316401007425	I-site; other site
316401007426	8 probable transmembrane helices predicted for ETEC1817 by TMHMM2.0 at aa 58-77, 87-109, 121-143, 163-182, 195-214, 234-256, 263-285 and 295-317
316401007427	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
316401007428	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316401007429	metal binding site [ion binding]; metal-binding site
316401007430	active site
316401007431	I-site; other site
316401007432	Signal peptide predicted for ETEC1818 by SignalP 2.0 HMM (Signal peptide probability 0.918) with cleavage site probability 0.753 between residues 30 and 31
316401007433	2 probable transmembrane helices predicted for ETEC1818 by TMHMM2.0 at aa 7-29 and 305-327
316401007434	YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function.  The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336
316401007435	putative deacylase active site [active]
316401007436	1 probable transmembrane helix predicted for ETEC1820 by TMHMM2.0 at aa 10-29
316401007437	Predicted membrane protein [Function unknown]; Region: COG2707
316401007438	Signal peptide predicted for ETEC1821 by SignalP 2.0 HMM (Signal peptide probability 0.975) with cleavage site probability 0.511 between residues 24 and 25
316401007439	4 probable transmembrane helices predicted for ETEC1821 by TMHMM2.0 at aa 12-34, 49-71, 78-100 and 124-146
316401007440	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
316401007441	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316401007442	PS00041 Bacterial regulatory proteins, araC family signature.
316401007443	cyanate transporter; Region: CynX; TIGR00896
316401007444	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401007445	Signal peptide predicted for ETEC1823 by SignalP 2.0 HMM (Signal peptide probability 0.706) with cleavage site probability 0.528 between residues 33 and 34
316401007446	12 probable transmembrane helices predicted for ETEC1823 by TMHMM2.0 at aa 13-31, 46-68, 81-98, 103-125, 137-159, 163-185, 217-239, 249-271, 278-300, 304-326, 333-355 and 365-387
316401007447	Uncharacterized conserved protein [Function unknown]; Region: COG3189
316401007448	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
316401007449	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
316401007450	Domain of unknown function (DUF333); Region: DUF333; pfam03891
316401007451	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401007452	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
316401007453	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
316401007454	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
316401007455	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316401007456	metal binding site [ion binding]; metal-binding site
316401007457	active site
316401007458	I-site; other site
316401007459	hypothetical protein; Provisional; Region: PRK10457
316401007460	3 probable transmembrane helices predicted for ETEC1827 by TMHMM2.0 at aa 4-21, 28-50 and 60-77
316401007461	Domain of unknown function (DUF1869); Region: DUF1869; pfam08956
316401007462	Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615
316401007463	leucine export protein LeuE; Provisional; Region: PRK10958
316401007464	6 probable transmembrane helices predicted for ETEC1830 by TMHMM2.0 at aa 10-32, 45-67, 77-99, 120-142, 157-179 and 191-210
316401007465	transcriptional activator TtdR; Provisional; Region: PRK09801
316401007466	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401007467	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
316401007468	putative effector binding pocket; other site
316401007469	putative dimerization interface [polypeptide binding]; other site
316401007470	PS00044 Bacterial regulatory proteins, lysR family signature.
316401007471	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
316401007472	tartrate dehydrogenase; Region: TTC; TIGR02089
316401007473	PS00470 Isocitrate and isopropylmalate dehydrogenases signature.
316401007474	putative transporter; Provisional; Region: PRK09950
316401007475	10 probable transmembrane helices predicted for ETEC1833 by TMHMM2.0 at aa 31-53, 82-104, 136-158, 171-193, 206-228, 258-277, 289-308, 348-370, 390-409 and 419-441
316401007476	PS01303 BCCT family of transporters signature.
316401007477	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
316401007478	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
316401007479	[2Fe-2S] cluster binding site [ion binding]; other site
316401007480	C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886
316401007481	putative alpha subunit interface [polypeptide binding]; other site
316401007482	putative active site [active]
316401007483	putative substrate binding site [chemical binding]; other site
316401007484	Fe binding site [ion binding]; other site
316401007485	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
316401007486	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
316401007487	FMN-binding pocket [chemical binding]; other site
316401007488	flavin binding motif; other site
316401007489	phosphate binding motif [ion binding]; other site
316401007490	beta-alpha-beta structure motif; other site
316401007491	NAD binding pocket [chemical binding]; other site
316401007492	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
316401007493	catalytic loop [active]
316401007494	iron binding site [ion binding]; other site
316401007495	PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature.
316401007496	ribonuclease D; Provisional; Region: PRK10829
316401007497	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
316401007498	catalytic site [active]
316401007499	putative active site [active]
316401007500	putative substrate binding site [chemical binding]; other site
316401007501	Helicase and RNase D C-terminal; Region: HRDC; smart00341
316401007502	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
316401007503	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
316401007504	acyl-activating enzyme (AAE) consensus motif; other site
316401007505	putative AMP binding site [chemical binding]; other site
316401007506	putative active site [active]
316401007507	putative CoA binding site [chemical binding]; other site
316401007508	PS00455 Putative AMP-binding domain signature.
316401007509	PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature.
316401007510	outer membrane lipoprotein, Slp family; Region: slp; TIGR00752
316401007511	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401007512	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
316401007513	Glycoprotease family; Region: Peptidase_M22; pfam00814
316401007514	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
316401007515	DEAD/DEAH box helicase; Region: DEAD; pfam00270
316401007516	DEAD_2; Region: DEAD_2; pfam06733
316401007517	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
316401007518	PS00017 ATP/GTP-binding site motif A (P-loop).
316401007519	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
316401007520	homotrimer interaction site [polypeptide binding]; other site
316401007521	putative active site [active]
316401007522	PS01094 Uncharacterized protein family UPF0076 signature.
316401007523	IS1 transposase; Region: DDE_Tnp_IS1; pfam03400
316401007524	Domain of unknown function (DUF1889); Region: DUF1889; pfam08986
316401007525	hypothetical protein; Provisional; Region: PRK05114
316401007526	aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465
316401007527	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
316401007528	aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553
316401007529	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
316401007530	putative active site [active]
316401007531	putative CoA binding site [chemical binding]; other site
316401007532	nudix motif; other site
316401007533	metal binding site [ion binding]; metal-binding site
316401007534	PS01293 Uncharacterized protein family UPF0035 signature.
316401007535	L-serine deaminase; Provisional; Region: PRK15023
316401007536	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
316401007537	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
316401007538	phage resistance protein; Provisional; Region: PRK10551
316401007539	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
316401007540	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
316401007541	Signal peptide predicted for ETEC1847 by SignalP 2.0 HMM (Signal peptide probability 0.962) with cleavage site probability 0.667 between residues 28 and 29
316401007542	1 probable transmembrane helix predicted for ETEC1847 by TMHMM2.0 at aa 17-36
316401007543	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
316401007544	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
316401007545	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
316401007546	Transporter associated domain; Region: CorC_HlyC; smart01091
316401007547	7 probable transmembrane helices predicted for ETEC1848 by TMHMM2.0 at aa 13-35, 48-70, 85-102, 123-145, 150-172, 185-207 and 212-231
316401007548	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
316401007549	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
316401007550	active pocket/dimerization site; other site
316401007551	active site
316401007552	phosphorylation site [posttranslational modification]
316401007553	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
316401007554	active site
316401007555	phosphorylation site [posttranslational modification]
316401007556	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
316401007557	7 probable transmembrane helices predicted for ETEC1850 by TMHMM2.0 at aa 5-27, 34-56, 66-88, 95-117, 137-159, 180-202 and 217-239
316401007558	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401007559	PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103
316401007560	2 probable transmembrane helices predicted for ETEC1851 by TMHMM2.0 at aa 135-157 and 262-284
316401007561	Predicted membrane protein [Function unknown]; Region: COG4811
316401007562	Signal peptide predicted for ETEC1852 by SignalP 2.0 HMM (Signal peptide probability 0.652) with cleavage site probability 0.631 between residues 19 and 20
316401007563	2 probable transmembrane helices predicted for ETEC1852 by TMHMM2.0 at aa 7-26 and 65-87
316401007564	hypothetical protein; Provisional; Region: PRK11469
316401007565	Domain of unknown function DUF; Region: DUF204; pfam02659
316401007566	Domain of unknown function DUF; Region: DUF204; pfam02659
316401007567	Signal peptide predicted for ETEC1853 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.998 between residues 19 and 20
316401007568	5 probable transmembrane helices predicted for ETEC1853 by TMHMM2.0 at aa 7-29, 64-86, 106-128, 133-155 and 168-187
316401007569	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
316401007570	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316401007571	S-adenosylmethionine binding site [chemical binding]; other site
316401007572	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
316401007573	DNA-binding site [nucleotide binding]; DNA binding site
316401007574	RNA-binding motif; other site
316401007575	PS00352 'Cold-shock' DNA-binding domain signature.
316401007576	Protein of unknown function (DUF2627); Region: DUF2527; pfam10736
316401007577	YebO-like protein; Region: YebO; pfam13974
316401007578	1 probable transmembrane helix predicted for ETEC1857 by TMHMM2.0 at aa 10-32
316401007579	PhoPQ regulatory protein; Provisional; Region: PRK10299
316401007580	1 probable transmembrane helix predicted for ETEC1858 by TMHMM2.0 at aa 7-24
316401007581	Signal peptide predicted for ETEC1858 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 21 and 22
316401007582	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401007583	YobH-like protein; Region: YobH; pfam13996
316401007584	Signal peptide predicted for ETEC1859 by SignalP 2.0 HMM (Signal peptide probability 0.864) with cleavage site probability 0.570 between residues 33 and 34
316401007585	1 probable transmembrane helix predicted for ETEC1859 by TMHMM2.0 at aa 7-29
316401007586	DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090
316401007587	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
316401007588	dimerization interface [polypeptide binding]; other site
316401007589	putative Zn2+ binding site [ion binding]; other site
316401007590	putative DNA binding site [nucleotide binding]; other site
316401007591	Bacterial transcriptional regulator; Region: IclR; pfam01614
316401007592	PS01051 Bacterial regulatory proteins, iclR family signature.
316401007593	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401007594	Major Facilitator Superfamily; Region: MFS_1; pfam07690
316401007595	putative substrate translocation pore; other site
316401007596	12 probable transmembrane helices predicted for ETEC1861 by TMHMM2.0 at aa 21-43, 53-75, 87-109, 113-132, 144-166, 171-193, 205-227, 231-249, 269-291, 306-328, 335-357 and 428-450
316401007597	heat shock protein HtpX; Provisional; Region: PRK05457
316401007598	PS00017 ATP/GTP-binding site motif A (P-loop).
316401007599	4 probable transmembrane helices predicted for ETEC1862 by TMHMM2.0 at aa 5-27, 32-54, 158-180 and 195-217
316401007600	Signal peptide predicted for ETEC1862 by SignalP 2.0 HMM (Signal peptide probability 0.955) with cleavage site probability 0.205 between residues 23 and 24
316401007601	carboxy-terminal protease; Provisional; Region: PRK11186
316401007602	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
316401007603	protein binding site [polypeptide binding]; other site
316401007604	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
316401007605	Catalytic dyad [active]
316401007606	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
316401007607	Signal peptide predicted for ETEC1863 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 22 and 23
316401007608	ProP expression regulator; Provisional; Region: PRK04950
316401007609	ProQ/FINO family; Region: ProQ; pfam04352
316401007610	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
316401007611	GAF domain; Region: GAF_2; pfam13185
316401007612	PS01320 Uncharacterized protein family UPF0067 signature.
316401007613	integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155
316401007614	Paraquat-inducible protein A; Region: PqiA; pfam04403
316401007615	Paraquat-inducible protein A; Region: PqiA; pfam04403
316401007616	8 probable transmembrane helices predicted for ETEC1866 by TMHMM2.0 at aa 65-84, 119-141, 162-184, 188-210, 266-288, 316-338, 351-373 and 383-405
316401007617	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
316401007618	mce related protein; Region: MCE; pfam02470
316401007619	mce related protein; Region: MCE; pfam02470
316401007620	mce related protein; Region: MCE; pfam02470
316401007621	mce related protein; Region: MCE; pfam02470
316401007622	mce related protein; Region: MCE; pfam02470
316401007623	1 probable transmembrane helix predicted for ETEC1867 by TMHMM2.0 at aa 20-39
316401007624	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
316401007625	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316401007626	S-adenosylmethionine binding site [chemical binding]; other site
316401007627	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
316401007628	PS01153 NOL1/NOP2/sun family signature.
316401007629	Protein of unknown function (DUF1480); Region: DUF1480; pfam07351
316401007630	Protein of unknown function (DUF1482); Region: DUF1482; pfam07358
316401007631	serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439
316401007632	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
316401007633	PS00125 Serine/threonine specific protein phosphatases signature.
316401007634	Protein of unknown function (DUF2511); Region: DUF2511; pfam10709
316401007635	1 probable transmembrane helix predicted for ETEC1872 by TMHMM2.0 at aa 5-27
316401007636	Signal peptide predicted for ETEC1872 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 20 and 21
316401007637	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
316401007638	8 probable transmembrane helices predicted for ETEC1873 by TMHMM2.0 at aa 11-30, 51-73, 93-110, 117-136, 151-170, 190-212, 227-249 and 262-284
316401007639	hypothetical protein; Provisional; Region: PRK10301
316401007640	Signal peptide predicted for ETEC1874 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.834 between residues 26 and 27
316401007641	DNA polymerase III subunit theta; Reviewed; Region: PRK10969
316401007642	Predicted amidohydrolase [General function prediction only]; Region: COG0388
316401007643	Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795
316401007644	exodeoxyribonuclease X; Provisional; Region: PRK07983
316401007645	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
316401007646	active site
316401007647	catalytic site [active]
316401007648	substrate binding site [chemical binding]; other site
316401007649	protease 2; Provisional; Region: PRK10115
316401007650	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
316401007651	PS00708 Prolyl endopeptidase family serine active site.
316401007652	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979
316401007653	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
316401007654	putative metal binding site [ion binding]; other site
316401007655	2 probable transmembrane helices predicted for ETEC1879 by TMHMM2.0 at aa 26-45 and 52-74
316401007656	Signal peptide predicted for ETEC1879 by SignalP 2.0 HMM (Signal peptide probability 0.743) with cleavage site probability 0.633 between residues 23 and 24
316401007657	hypothetical protein; Provisional; Region: PRK13680
316401007658	Signal peptide predicted for ETEC1880 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.986 between residues 25 and 26
316401007659	DNA damage-inducible protein YebG; Provisional; Region: PRK10061
316401007660	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
316401007661	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
316401007662	ATP-grasp domain; Region: ATP-grasp; pfam02222
316401007663	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
316401007664	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
316401007665	active site
316401007666	intersubunit interface [polypeptide binding]; other site
316401007667	catalytic residue [active]
316401007668	PS00160 KDPG and KHG aldolases Schiff-base forming residue.
316401007669	PS00159 KDPG and KHG aldolases active site.
316401007670	phosphogluconate dehydratase; Validated; Region: PRK09054
316401007671	6-phosphogluconate dehydratase; Region: edd; TIGR01196
316401007672	PS00887 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 2.
316401007673	PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1.
316401007674	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
316401007675	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
316401007676	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
316401007677	PS00069 Glucose-6-phosphate dehydrogenase active site.
316401007678	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
316401007679	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
316401007680	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
316401007681	putative active site [active]
316401007682	pyruvate kinase; Provisional; Region: PRK05826
316401007683	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
316401007684	domain interfaces; other site
316401007685	active site
316401007686	PS00110 Pyruvate kinase active site signature.
316401007687	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
316401007688	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
316401007689	putative acyl-acceptor binding pocket; other site
316401007690	1 probable transmembrane helix predicted for ETEC1888 by TMHMM2.0 at aa 23-40
316401007691	putative peptidase; Provisional; Region: PRK11649
316401007692	Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525
316401007693	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
316401007694	Peptidase family M23; Region: Peptidase_M23; pfam01551
316401007695	1 probable transmembrane helix predicted for ETEC1889 by TMHMM2.0 at aa 21-40
316401007696	high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545
316401007697	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
316401007698	metal binding site [ion binding]; metal-binding site
316401007699	Signal peptide predicted for ETEC1890 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.940 between residues 23 and 24
316401007700	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
316401007701	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
316401007702	PS00017 ATP/GTP-binding site motif A (P-loop).
316401007703	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
316401007704	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
316401007705	ABC-ATPase subunit  interface; other site
316401007706	dimer interface [polypeptide binding]; other site
316401007707	putative PBP binding regions; other site
316401007708	Signal peptide predicted for ETEC1892 by SignalP 2.0 HMM (Signal peptide probability 0.786) with cleavage site probability 0.322 between residues 18 and 19
316401007709	7 probable transmembrane helices predicted for ETEC1892 by TMHMM2.0 at aa 5-27, 48-70, 85-107, 127-145, 170-192, 213-235 and 239-256
316401007710	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401007711	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
316401007712	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316401007713	Walker A motif; other site
316401007714	ATP binding site [chemical binding]; other site
316401007715	Walker B motif; other site
316401007716	arginine finger; other site
316401007717	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
316401007718	PS00017 ATP/GTP-binding site motif A (P-loop).
316401007719	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
316401007720	RuvA N terminal domain; Region: RuvA_N; pfam01330
316401007721	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
316401007722	hypothetical protein; Provisional; Region: PRK11470
316401007723	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
316401007724	active site
316401007725	putative DNA-binding cleft [nucleotide binding]; other site
316401007726	dimer interface [polypeptide binding]; other site
316401007727	PS01321 Crossover junction endodeoxyribonuclease ruvC signature.
316401007728	hypothetical protein; Validated; Region: PRK00110
316401007729	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
316401007730	nudix motif; other site
316401007731	PS00893 mutT domain signature.
316401007732	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
316401007733	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
316401007734	dimer interface [polypeptide binding]; other site
316401007735	anticodon binding site; other site
316401007736	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
316401007737	homodimer interface [polypeptide binding]; other site
316401007738	motif 1; other site
316401007739	active site
316401007740	motif 2; other site
316401007741	GAD domain; Region: GAD; pfam02938
316401007742	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
316401007743	motif 3; other site
316401007744	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
316401007745	PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1.
316401007746	Isochorismatase family; Region: Isochorismatase; pfam00857
316401007747	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
316401007748	catalytic triad [active]
316401007749	conserved cis-peptide bond; other site
316401007750	PS00867 Carbamoyl-phosphate synthase subdomain signature 2.
316401007751	hypothetical protein; Provisional; Region: PRK10302
316401007752	Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788
316401007753	3 probable transmembrane helices predicted for ETEC1902 by TMHMM2.0 at aa 2-24, 71-93 and 106-128
316401007754	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316401007755	S-adenosylmethionine binding site [chemical binding]; other site
316401007756	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316401007757	S-adenosylmethionine binding site [chemical binding]; other site
316401007759	trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162
316401007760	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
316401007761	PS00190 Cytochrome c family heme-binding site signature.
316401007762	PS00190 Cytochrome c family heme-binding site signature.
316401007763	PS00190 Cytochrome c family heme-binding site signature.
316401007764	PS00190 Cytochrome c family heme-binding site signature.
316401007765	PS00190 Cytochrome c family heme-binding site signature.
316401007766	Signal peptide predicted for ETEC1906 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.940 between residues 26 and 27
316401007767	1 probable transmembrane helix predicted for ETEC1906 by TMHMM2.0 at aa 7-26
316401007768	copper homeostasis protein CutC; Provisional; Region: PRK11572
316401007769	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268
316401007770	putative metal binding site [ion binding]; other site
316401007771	PS00414 Profilin signature.
316401007772	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
316401007773	arginyl-tRNA synthetase; Region: argS; TIGR00456
316401007774	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
316401007775	active site
316401007776	HIGH motif; other site
316401007777	KMSK motif region; other site
316401007778	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
316401007779	tRNA binding surface [nucleotide binding]; other site
316401007780	anticodon binding site; other site
316401007781	PS00178 Aminoacyl-transfer RNA synthetases class-I signature.
316401007782	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755
316401007783	Signal peptide predicted for ETEC1910 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.999 between residues 18 and 19
316401007784	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401007785	Flagellar protein FlhE; Region: FlhE; pfam06366
316401007786	Signal peptide predicted for ETEC1911 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.972 between residues 16 and 17
316401007787	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
316401007788	FHIPEP family; Region: FHIPEP; pfam00771
316401007789	7 probable transmembrane helices predicted for ETEC1912 by TMHMM2.0 at aa 21-43, 47-64, 76-98, 113-135, 209-231, 251-273 and 285-307
316401007790	PS00994 Bacterial export FHIPEP family signature.
316401007791	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
316401007792	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
316401007793	4 probable transmembrane helices predicted for ETEC1913 by TMHMM2.0 at aa 34-53, 92-114, 145-167 and 188-210
316401007794	PS00017 ATP/GTP-binding site motif A (P-loop).
316401007795	chemotaxis regulator CheZ; Provisional; Region: PRK11166
316401007796	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
316401007797	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316401007798	active site
316401007799	phosphorylation site [posttranslational modification]
316401007800	intermolecular recognition site; other site
316401007801	dimerization interface [polypeptide binding]; other site
316401007802	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
316401007803	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316401007804	active site
316401007805	phosphorylation site [posttranslational modification]
316401007806	intermolecular recognition site; other site
316401007807	dimerization interface [polypeptide binding]; other site
316401007808	CheB methylesterase; Region: CheB_methylest; pfam01339
316401007809	chemotaxis methyltransferase CheR; Provisional; Region: PRK10611
316401007810	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
316401007811	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316401007812	S-adenosylmethionine binding site [chemical binding]; other site
316401007813	methyl-accepting protein IV; Provisional; Region: PRK09793
316401007814	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
316401007815	dimer interface [polypeptide binding]; other site
316401007816	ligand binding site [chemical binding]; other site
316401007817	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
316401007818	dimerization interface [polypeptide binding]; other site
316401007819	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316401007820	dimer interface [polypeptide binding]; other site
316401007821	putative CheW interface [polypeptide binding]; other site
316401007822	PS00538 Bacterial chemotaxis sensory transducers signature.
316401007823	2 probable transmembrane helices predicted for ETEC1918 by TMHMM2.0 at aa 10-32 and 187-209
316401007824	Signal peptide predicted for ETEC1918 by SignalP 2.0 HMM (Signal peptide probability 0.891) with cleavage site probability 0.595 between residues 27 and 28
316401007825	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
316401007826	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
316401007827	dimer interface [polypeptide binding]; other site
316401007828	ligand binding site [chemical binding]; other site
316401007829	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
316401007830	dimerization interface [polypeptide binding]; other site
316401007831	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316401007832	dimer interface [polypeptide binding]; other site
316401007833	putative CheW interface [polypeptide binding]; other site
316401007834	PS00538 Bacterial chemotaxis sensory transducers signature.
316401007835	2 probable transmembrane helices predicted for ETEC1919 by TMHMM2.0 at aa 7-29 and 190-212
316401007836	Signal peptide predicted for ETEC1919 by SignalP 2.0 HMM (Signal peptide probability 0.914) with cleavage site probability 0.446 between residues 19 and 20
316401007837	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
316401007838	putative CheA interaction surface; other site
316401007839	chemotaxis protein CheA; Provisional; Region: PRK10547
316401007840	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
316401007841	putative binding surface; other site
316401007842	active site
316401007843	CheY binding; Region: CheY-binding; pfam09078
316401007844	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
316401007845	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316401007846	ATP binding site [chemical binding]; other site
316401007847	Mg2+ binding site [ion binding]; other site
316401007848	G-X-G motif; other site
316401007849	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
316401007850	PS00039 DEAD-box subfamily ATP-dependent helicases signature.
316401007851	flagellar motor protein MotB; Validated; Region: motB; PRK09041
316401007852	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
316401007853	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
316401007854	ligand binding site [chemical binding]; other site
316401007855	1 probable transmembrane helix predicted for ETEC1922 by TMHMM2.0 at aa 21-43
316401007856	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
316401007857	flagellar motor protein MotA; Validated; Region: PRK09110
316401007858	4 probable transmembrane helices predicted for ETEC1923 by TMHMM2.0 at aa 7-29, 34-51, 171-190 and 205-227
316401007859	PS01307 Flagellar motor protein motA family signature.
316401007860	transcriptional activator FlhC; Provisional; Region: PRK12722
316401007861	transcriptional activator FlhD; Provisional; Region: PRK02909
316401007862	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
316401007863	Ligand Binding Site [chemical binding]; other site
316401007864	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
316401007865	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
316401007866	active site
316401007867	homotetramer interface [polypeptide binding]; other site
316401007868	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187
316401007869	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
316401007870	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
316401007871	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
316401007872	TM-ABC transporter signature motif; other site
316401007873	10 probable transmembrane helices predicted for ETEC1929 by TMHMM2.0 at aa 28-50, 54-73, 80-99, 103-125, 132-151, 171-193, 223-242, 252-270, 277-294 and 299-318
316401007874	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401007875	L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288
316401007876	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
316401007877	Walker A/P-loop; other site
316401007878	ATP binding site [chemical binding]; other site
316401007879	Q-loop/lid; other site
316401007880	ABC transporter signature motif; other site
316401007881	Walker B; other site
316401007882	D-loop; other site
316401007883	H-loop/switch region; other site
316401007884	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
316401007885	PS00211 ABC transporters family signature.
316401007886	PS00217 Sugar transport proteins signature 2.
316401007887	PS00017 ATP/GTP-binding site motif A (P-loop).
316401007888	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
316401007889	Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540
316401007890	ligand binding site [chemical binding]; other site
316401007891	Signal peptide predicted for ETEC1931 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 23 and 24
316401007892	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
316401007893	Ferritin-like domain; Region: Ferritin; pfam00210
316401007894	ferroxidase diiron center [ion binding]; other site
316401007895	Protein of unknown function (DUF2766); Region: DUF2766; pfam10964
316401007896	YecR-like lipoprotein; Region: YecR; pfam13992
316401007897	Signal peptide predicted for ETEC1934 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.529 between residues 24 and 25
316401007898	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401007899	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
316401007900	Ferritin-like domain; Region: Ferritin; pfam00210
316401007901	ferroxidase diiron center [ion binding]; other site
316401007902	probable metal-binding protein; Region: matur_matur; TIGR03853
316401007903	tyrosine transporter TyrP; Provisional; Region: PRK15132
316401007904	aromatic amino acid transport protein; Region: araaP; TIGR00837
316401007905	Signal peptide predicted for ETEC1937 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.664 between residues 28 and 29
316401007906	11 probable transmembrane helices predicted for ETEC1937 by TMHMM2.0 at aa 7-29, 33-55, 78-100, 115-137, 144-166, 181-203, 216-238, 273-295, 308-330, 335-357 and 377-399
316401007907	PS00594 Aromatic amino acids permeases signature.
316401007908	hypothetical protein; Provisional; Region: PRK10396
316401007909	yecA family protein; Region: ygfB_yecA; TIGR02292
316401007910	SEC-C motif; Region: SEC-C; pfam02810
316401007911	PS00294 Prenyl group binding site (CAAX box).
316401007912	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
316401007913	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
316401007914	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
316401007915	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
316401007916	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
316401007917	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
316401007918	Transposase; Region: HTH_Tnp_1; pfam01527
316401007919	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
316401007920	AIPR protein; Region: AIPR; pfam10592
316401007921	PS00867 Carbamoyl-phosphate synthase subdomain signature 2.
316401007922	Domain of unknown function (DUF4420); Region: DUF4420; pfam14390
316401007923	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401007924	Z1 domain; Region: Z1; pfam10593
316401007925	PS00017 ATP/GTP-binding site motif A (P-loop).
316401007926	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316401007927	ATP binding site [chemical binding]; other site
316401007928	Mg2+ binding site [ion binding]; other site
316401007929	G-X-G motif; other site
316401007930	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
316401007931	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
316401007932	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
316401007933	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
316401007934	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
316401007935	DNA binding residues [nucleotide binding]
316401007936	PS00716 Sigma-70 factors family signature 2.
316401007937	PS00715 Sigma-70 factors family signature 1.
316401007938	Restriction endonuclease; Region: Mrr_cat; pfam04471
316401007939	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281
316401007940	PS00017 ATP/GTP-binding site motif A (P-loop).
316401007941	Protein of unknown function DUF262; Region: DUF262; pfam03235
316401007942	Uncharacterized conserved protein [Function unknown]; Region: COG1479
316401007943	Protein of unknown function DUF262; Region: DUF262; pfam03235
316401007944	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
316401007945	Protein of unknown function DUF45; Region: DUF45; pfam01863
316401007946	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
316401007947	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
316401007948	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
316401007949	ATP binding site [chemical binding]; other site
316401007950	putative Mg++ binding site [ion binding]; other site
316401007951	hypothetical protein; Provisional; Region: PRK10396
316401007952	yecA family protein; Region: ygfB_yecA; TIGR02292
316401007953	SEC-C motif; Region: SEC-C; pfam02810
316401007954	PS00294 Prenyl group binding site (CAAX box).
316401007955	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
316401007956	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
316401007957	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
316401007958	HsdM N-terminal domain; Region: HsdM_N; pfam12161
316401007959	Methyltransferase domain; Region: Methyltransf_26; pfam13659
316401007960	Domain of unknown function (DUF4102); Region: DUF4102; pfam13356
316401007961	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
316401007962	active site
316401007963	Int/Topo IB signature motif; other site
316401007964	DNA binding site [nucleotide binding]
316401007965	DNA polymerase type B, organellar and viral; Region: DNA_pol_B_2; pfam03175
316401007966	Predicted transcriptional regulator [Transcription]; Region: COG2378
316401007967	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
316401007968	WYL domain; Region: WYL; pfam13280
316401007969	Protein of unknown function (DUF2787); Region: DUF2787; pfam10980
316401007970	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
316401007971	active site
316401007972	Int/Topo IB signature motif; other site
316401007973	DNA binding site [nucleotide binding]
316401007974	integrase; Provisional; Region: int; PHA02601
316401007975	Phage HP1 integrase, C-terminal catalytic domain. Bacteriophage HP1 and related integrases are found in eubacteria, plasmids and temperate bacteriophages of the P2 family.  They belong to the DNA breaking-rejoining enzyme superfamily, which includes...; Region: HP1_INT_C; cd00797
316401007976	dimer interface [polypeptide binding]; other site
316401007977	active site
316401007978	catalytic residues [active]
316401007979	Int/Topo IB signature motif; other site
316401007980	Protein of unknown function (DUF2511); Region: DUF2511; pfam10709
316401007981	Signal peptide predicted for ETEC1970 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 22 and 23
316401007982	flagella biosynthesis regulator; Provisional; Region: flk; PRK10715
316401007983	1 probable transmembrane helix predicted for ETEC1971 by TMHMM2.0 at aa 195-214
316401007984	Transcriptional regulators [Transcription]; Region: MarR; COG1846
316401007985	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
316401007986	putative DNA binding site [nucleotide binding]; other site
316401007987	putative Zn2+ binding site [ion binding]; other site
316401007988	Ash protein family; Region: Phage_ASH; pfam10554
316401007989	Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840
316401007990	plasmid segregation protein ParM; Provisional; Region: PRK13917
316401007991	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
316401007992	Mg binding site [ion binding]; other site
316401007993	nucleotide binding site [chemical binding]; other site
316401007994	putative protofilament interface [polypeptide binding]; other site
316401007995	Plasmid stability protein; Region: Plasmid_stab_B; pfam10784
316401007996	Signal peptide predicted for ETEC1985 by SignalP 2.0 HMM (Signal peptide probability 0.671) with cleavage site probability 0.585 between residues 22 and 23
316401007997	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
316401007998	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
316401007999	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
316401008000	PS00017 ATP/GTP-binding site motif A (P-loop).
316401008001	IS1 transposase; Region: DDE_Tnp_IS1; pfam03400
316401008002	Phage-related protein [Function unknown]; Region: COG4695; cl01923
316401008003	Phage portal protein; Region: Phage_portal; pfam04860
316401008004	terminase ATPase subunit; Provisional; Region: P; PHA02535
316401008005	Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056
316401008006	Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838
316401008007	Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947
316401008008	terminase endonuclease subunit; Provisional; Region: M; PHA02537
316401008009	Phage small terminase subunit; Region: Phage_term_smal; pfam05944
316401008010	Phage head completion protein (GPL); Region: Phage_GPL; pfam05926
316401008011	Phage Tail Protein X; Region: Phage_tail_X; pfam05489
316401008012	Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938
316401008013	2 probable transmembrane helices predicted for ETEC1996 by TMHMM2.0 at aa 21-43 and 53-75
316401008014	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
316401008015	Protein of unknown function (DUF2570); Region: DUF2570; pfam10828
316401008016	Signal peptide predicted for ETEC1998 by SignalP 2.0 HMM (Signal peptide probability 0.974) with cleavage site probability 0.581 between residues 24 and 25
316401008017	1 probable transmembrane helix predicted for ETEC1998 by TMHMM2.0 at aa 4-26
316401008018	P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891
316401008019	Phage virion morphogenesis family; Region: Phage_tail_S; cl02089
316401008020	Phage virion morphogenesis family; Region: Phage_tail_S; cl02089
316401008021	Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540
316401008022	PS00017 ATP/GTP-binding site motif A (P-loop).
316401008023	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
316401008024	Baseplate J-like protein; Region: Baseplate_J; cl01294
316401008025	Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385
316401008026	Signal peptide predicted for ETEC2004 by SignalP 2.0 HMM (Signal peptide probability 0.745) with cleavage site probability 0.668 between residues 19 and 20
316401008027	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
316401008028	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
316401008029	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
316401008030	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
316401008031	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
316401008032	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
316401008033	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
316401008035	multiple promoter invertase; Provisional; Region: mpi; PRK13413
316401008036	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
316401008037	catalytic residues [active]
316401008038	catalytic nucleophile [active]
316401008039	Presynaptic Site I dimer interface [polypeptide binding]; other site
316401008040	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
316401008041	Synaptic Flat tetramer interface [polypeptide binding]; other site
316401008042	Synaptic Site I dimer interface [polypeptide binding]; other site
316401008043	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
316401008044	DNA-binding interface [nucleotide binding]; DNA binding site
316401008045	PS00397 Site-specific recombinases active site.
316401008046	PS00398 Site-specific recombinases signature 2.
316401008047	Phage protein U [General function prediction only]; Region: COG3499
316401008048	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
316401008049	PS00225 Crystallins beta and gamma 'Greek key' motif signature.
316401008050	3 probable transmembrane helices predicted for ETEC2011 by TMHMM2.0 at aa 529-551, 558-580 and 590-612
316401008051	PS00215 Mitochondrial energy transfer proteins signature.
316401008052	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
316401008053	Phage tail tube protein FII; Region: Phage_tube; cl01390
316401008054	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
316401008055	Phage protein D [General function prediction only]; Region: COG3500
316401008056	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
316401008057	Helix-turn-helix domain; Region: HTH_38; pfam13936
316401008058	Integrase core domain; Region: rve; pfam00665
316401008059	PS01043 Transposases, IS30 family, signature.
316401008060	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
316401008061	DNA-binding transcriptional regulator; Provisional; Region: PRK09678
316401008062	Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606
316401008063	PS00017 ATP/GTP-binding site motif A (P-loop).
316401008064	1 probable transmembrane helix predicted for ETEC2019 by TMHMM2.0 at aa 20-42
316401008065	phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832
316401008066	4 probable transmembrane helices predicted for ETEC2020 by TMHMM2.0 at aa 7-29, 33-52, 121-143 and 147-169
316401008067	PS00379 CDP-alcohol phosphatidyltransferases signature.
316401008068	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
316401008069	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
316401008070	GIY-YIG motif/motif A; other site
316401008071	active site
316401008072	catalytic site [active]
316401008073	putative DNA binding site [nucleotide binding]; other site
316401008074	metal binding site [ion binding]; metal-binding site
316401008075	UvrB/uvrC motif; Region: UVR; pfam02151
316401008076	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
316401008077	Helix-hairpin-helix motif; Region: HHH; pfam00633
316401008078	response regulator; Provisional; Region: PRK09483
316401008079	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316401008080	active site
316401008081	phosphorylation site [posttranslational modification]
316401008082	intermolecular recognition site; other site
316401008083	dimerization interface [polypeptide binding]; other site
316401008084	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
316401008085	DNA binding residues [nucleotide binding]
316401008086	dimerization interface [polypeptide binding]; other site
316401008087	PS00622 Bacterial regulatory proteins, luxR family signature.
316401008088	hypothetical protein; Provisional; Region: PRK10613
316401008089	DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188
316401008090	Autoinducer binding domain; Region: Autoind_bind; pfam03472
316401008091	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
316401008092	DNA binding residues [nucleotide binding]
316401008093	dimerization interface [polypeptide binding]; other site
316401008094	PS00622 Bacterial regulatory proteins, luxR family signature.
316401008095	putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264
316401008096	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
316401008097	Walker A/P-loop; other site
316401008098	ATP binding site [chemical binding]; other site
316401008099	Q-loop/lid; other site
316401008100	ABC transporter signature motif; other site
316401008101	Walker B; other site
316401008102	D-loop; other site
316401008103	H-loop/switch region; other site
316401008104	PS00211 ABC transporters family signature.
316401008105	PS00017 ATP/GTP-binding site motif A (P-loop).
316401008106	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
316401008107	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401008108	dimer interface [polypeptide binding]; other site
316401008109	conserved gate region; other site
316401008110	putative PBP binding loops; other site
316401008111	ABC-ATPase subunit interface; other site
316401008112	3 probable transmembrane helices predicted for ETEC2026 by TMHMM2.0 at aa 20-42, 54-76 and 185-207
316401008113	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
316401008114	D-cysteine desulfhydrase; Validated; Region: PRK03910
316401008115	Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449
316401008116	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316401008117	catalytic residue [active]
316401008118	cystine transporter subunit; Provisional; Region: PRK11260
316401008119	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
316401008120	substrate binding pocket [chemical binding]; other site
316401008121	membrane-bound complex binding site; other site
316401008122	hinge residues; other site
316401008123	PS01039 Bacterial extracellular solute-binding proteins, family 3 signature.
316401008124	Signal peptide predicted for ETEC2028 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 29 and 30
316401008125	Similar to N-terminus of Escherichia coli. FliZ UniProt:P52627 (EMBL:U18539 (183 aa) fasta scores: E()=5.1e-43, 99.074% id in 108 aa, and to N-terminus of Escherichia coli B. phage integrase domain protein sam domain protein. UniProt:A2UMZ3 (EMBL:AAWW01000050 (183 aa) fasta scores: E()=5.1e-43, 99.074% id in 108 aa
316401008126	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
316401008127	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
316401008128	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
316401008129	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
316401008130	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
316401008131	DNA binding residues [nucleotide binding]
316401008132	PS00716 Sigma-70 factors family signature 2.
316401008133	PS00715 Sigma-70 factors family signature 1.
316401008134	flagellin; Validated; Region: PRK08026
316401008135	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
316401008136	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
316401008137	flagellar capping protein; Reviewed; Region: fliD; PRK08032
316401008138	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
316401008139	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
316401008140	flagellar biosynthesis protein FliT; Provisional; Region: PRK10548
316401008141	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
316401008142	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
316401008143	active site
316401008144	Na/Ca binding site [ion binding]; other site
316401008145	catalytic site [active]
316401008146	lipoprotein; Provisional; Region: PRK10397
316401008147	Signal peptide predicted for ETEC2036 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.882 between residues 19 and 20
316401008148	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401008149	putative inner membrane protein; Provisional; Region: PRK11099
316401008150	10 probable transmembrane helices predicted for ETEC2037 by TMHMM2.0 at aa 21-43, 81-103, 116-138, 148-170, 197-214, 224-246, 258-280, 284-306, 319-341 and 361-383
316401008151	YedF is a bacterial SirA-like protein of unknown function.  SirA  (also known as UvrY,  and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422
316401008152	CPxP  motif; other site
316401008153	PS01148 Uncharacterized protein family UPF0033 signature.
316401008154	hypothetical protein; Provisional; Region: PRK09951
316401008155	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253
316401008156	flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206
316401008157	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
316401008158	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
316401008159	Signal peptide predicted for ETEC2041 by SignalP 2.0 HMM (Signal peptide probability 0.975) with cleavage site probability 0.972 between residues 43 and 44
316401008160	2 probable transmembrane helices predicted for ETEC2041 by TMHMM2.0 at aa 21-43 and 446-468
316401008161	flagellar motor switch protein FliG; Region: fliG; TIGR00207
316401008162	FliG C-terminal domain; Region: FliG_C; pfam01706
316401008163	flagellar assembly protein H; Validated; Region: fliH; PRK05687
316401008164	Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811
316401008165	Flagellar assembly protein FliH; Region: FliH; pfam02108
316401008166	flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960
316401008167	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
316401008168	Walker A motif/ATP binding site; other site
316401008169	Walker B motif; other site
316401008170	PS00017 ATP/GTP-binding site motif A (P-loop).
316401008171	PS00152 ATP synthase alpha and beta subunits signature.
316401008172	Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882
316401008173	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
316401008174	Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144
316401008175	flagellar hook-length control protein; Provisional; Region: PRK10118
316401008176	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021
316401008177	Signal peptide predicted for ETEC2047 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.686 between residues 42 and 43
316401008178	1 probable transmembrane helix predicted for ETEC2047 by TMHMM2.0 at aa 13-35
316401008179	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401008180	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
316401008181	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
316401008182	flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963
316401008183	flagellar motor switch protein; Validated; Region: fliN; PRK05698
316401008184	flagellar biosynthesis protein FliO; Provisional; Region: PRK11486
316401008185	1 probable transmembrane helix predicted for ETEC2050 by TMHMM2.0 at aa 20-39
316401008186	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
316401008187	Signal peptide predicted for ETEC2051 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 21 and 22
316401008188	5 probable transmembrane helices predicted for ETEC2051 by TMHMM2.0 at aa 7-26, 46-68, 88-105, 185-207 and 214-236
316401008189	PS01060 Flagella transport protein fliP family signature 1.
316401008190	PS01061 Flagella transport protein fliP family signature 2.
316401008191	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
316401008192	Signal peptide predicted for ETEC2052 by SignalP 2.0 HMM (Signal peptide probability 0.963) with cleavage site probability 0.943 between residues 40 and 41
316401008193	2 probable transmembrane helices predicted for ETEC2052 by TMHMM2.0 at aa 20-42 and 52-74
316401008194	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
316401008195	5 probable transmembrane helices predicted for ETEC2053 by TMHMM2.0 at aa 12-34, 65-87, 132-154, 179-201 and 214-236
316401008196	colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411
316401008197	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
316401008198	DNA binding residues [nucleotide binding]
316401008199	dimerization interface [polypeptide binding]; other site
316401008200	PS00622 Bacterial regulatory proteins, luxR family signature.
316401008201	hypothetical protein; Provisional; Region: PRK10708
316401008202	Protein of unknown function (DUF2525); Region: DUF2525; pfam10733
316401008203	mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669
316401008204	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
316401008205	active site
316401008206	motif I; other site
316401008207	motif II; other site
316401008208	putative diguanylate cyclase YedQ; Provisional; Region: PRK15426
316401008209	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316401008210	metal binding site [ion binding]; metal-binding site
316401008211	active site
316401008212	I-site; other site
316401008213	2 probable transmembrane helices predicted for ETEC2058 by TMHMM2.0 at aa 20-42 and 358-380
316401008214	Uncharacterized small protein [Function unknown]; Region: COG5475
316401008215	hypothetical protein; Provisional; Region: PRK10062
316401008216	5 probable transmembrane helices predicted for ETEC2060 by TMHMM2.0 at aa 80-102, 152-171, 175-197, 232-254 and 269-291
316401008217	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
316401008218	EamA-like transporter family; Region: EamA; pfam00892
316401008219	10 probable transmembrane helices predicted for ETEC2061 by TMHMM2.0 at aa 7-29, 39-56, 68-87, 97-119, 126-145, 149-168, 175-197, 212-234, 241-263 and 268-290
316401008220	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
316401008221	additional DNA contacts [nucleotide binding]; other site
316401008222	mismatch recognition site; other site
316401008223	active site
316401008224	zinc binding site [ion binding]; other site
316401008225	DNA intercalation site [nucleotide binding]; other site
316401008226	DNA cytosine methylase; Provisional; Region: PRK10458
316401008227	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
316401008228	cofactor binding site; other site
316401008229	DNA binding site [nucleotide binding]
316401008230	substrate interaction site [chemical binding]; other site
316401008231	PS00095 C-5 cytosine-specific DNA methylases C-terminal signature.
316401008232	PS00094 C-5 cytosine-specific DNA methylases active site.
316401008233	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
316401008234	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
316401008235	Zn2+ binding site [ion binding]; other site
316401008236	Mg2+ binding site [ion binding]; other site
316401008237	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
316401008238	2 probable transmembrane helices predicted for ETEC2065 by TMHMM2.0 at aa 41-63 and 87-109
316401008239	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
316401008240	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
316401008241	eyelet of channel; other site
316401008242	trimer interface [polypeptide binding]; other site
316401008243	Signal peptide predicted for ETEC2066 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 21 and 22
316401008244	chaperone protein HchA; Provisional; Region: PRK04155
316401008245	Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148
316401008246	dimer interface [polypeptide binding]; other site
316401008247	metal binding site [ion binding]; metal-binding site
316401008248	potential oxyanion hole; other site
316401008249	potential catalytic triad [active]
316401008250	conserved cys residue [active]
316401008251	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
316401008252	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316401008253	dimer interface [polypeptide binding]; other site
316401008254	phosphorylation site [posttranslational modification]
316401008255	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316401008256	ATP binding site [chemical binding]; other site
316401008257	Mg2+ binding site [ion binding]; other site
316401008258	G-X-G motif; other site
316401008259	2 probable transmembrane helices predicted for ETEC2068 by TMHMM2.0 at aa 10-32 and 159-181
316401008260	Signal peptide predicted for ETEC2068 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.584 between residues 23 and 24
316401008261	transcriptional regulatory protein YedW; Provisional; Region: PRK11517
316401008262	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316401008263	active site
316401008264	phosphorylation site [posttranslational modification]
316401008265	intermolecular recognition site; other site
316401008266	dimerization interface [polypeptide binding]; other site
316401008267	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
316401008268	DNA binding site [nucleotide binding]
316401008269	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
316401008270	active site
316401008271	homotetramer interface [polypeptide binding]; other site
316401008272	Signal peptide predicted for ETEC2070 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.991 between residues 23 and 24
316401008273	1 probable transmembrane helix predicted for ETEC2070 by TMHMM2.0 at aa 5-24
316401008274	PS00768 Transthyretin signature 1.
316401008275	PS00769 Transthyretin signature 2.
316401008276	TMAO/DMSO reductase; Reviewed; Region: PRK05363
316401008277	YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107
316401008278	Moco binding site; other site
316401008279	metal coordination site [ion binding]; other site
316401008280	Signal peptide predicted for ETEC2071 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.999 between residues 44 and 45
316401008281	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
316401008282	6 probable transmembrane helices predicted for ETEC2072 by TMHMM2.0 at aa 13-30, 45-67, 80-102, 112-134, 150-167 and 177-199
316401008283	zinc/cadmium-binding protein; Provisional; Region: PRK10306
316401008284	Signal peptide predicted for ETEC2073 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.766 between residues 23 and 24
316401008285	DgsA anti-repressor MtfA; Provisional; Region: PRK15410
316401008286	PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.
316401008287	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
316401008288	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
316401008289	active site
316401008290	Int/Topo IB signature motif; other site
316401008291	salicylate synthase Irp9; Reviewed; Region: PRK06772
316401008292	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
316401008293	muropeptide transporter; Validated; Region: ampG; cl17669
316401008294	12 probable transmembrane helices predicted for ETEC2077 by TMHMM2.0 at aa 59-78, 88-110, 131-153, 163-185, 198-220, 225-247, 277-299, 309-331, 338-360, 375-397, 404-426 and 431-453
316401008295	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
316401008296	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
316401008297	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316401008298	Walker A/P-loop; other site
316401008299	ATP binding site [chemical binding]; other site
316401008300	Q-loop/lid; other site
316401008301	ABC transporter signature motif; other site
316401008302	Walker B; other site
316401008303	D-loop; other site
316401008304	H-loop/switch region; other site
316401008305	PS00211 ABC transporters family signature.
316401008306	PS00017 ATP/GTP-binding site motif A (P-loop).
316401008307	5 probable transmembrane helices predicted for ETEC2078 by TMHMM2.0 at aa 34-56, 66-88, 139-161, 165-187 and 273-295
316401008308	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401008309	Signal peptide predicted for ETEC2078 by SignalP 2.0 HMM (Signal peptide probability 0.965) with cleavage site probability 0.965 between residues 49 and 50
316401008310	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
316401008311	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
316401008312	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316401008313	Walker A/P-loop; other site
316401008314	ATP binding site [chemical binding]; other site
316401008315	Q-loop/lid; other site
316401008316	ABC transporter signature motif; other site
316401008317	Walker B; other site
316401008318	D-loop; other site
316401008319	H-loop/switch region; other site
316401008320	PS00211 ABC transporters family signature.
316401008321	PS00017 ATP/GTP-binding site motif A (P-loop).
316401008322	6 probable transmembrane helices predicted for ETEC2079 by TMHMM2.0 at aa 29-51, 61-80, 143-162, 166-184, 251-273 and 283-305
316401008323	Signal peptide predicted for ETEC2079 by SignalP 2.0 HMM (Signal peptide probability 0.983) with cleavage site probability 0.637 between residues 43 and 44
316401008324	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
316401008325	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316401008326	PS00041 Bacterial regulatory proteins, araC family signature.
316401008327	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
316401008328	Condensation domain; Region: Condensation; pfam00668
316401008329	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
316401008330	Nonribosomal peptide synthase; Region: NRPS; pfam08415
316401008331	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
316401008332	acyl-activating enzyme (AAE) consensus motif; other site
316401008333	AMP binding site [chemical binding]; other site
316401008334	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316401008335	S-adenosylmethionine binding site [chemical binding]; other site
316401008336	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
316401008337	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
316401008338	Condensation domain; Region: Condensation; pfam00668
316401008339	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
316401008340	Nonribosomal peptide synthase; Region: NRPS; pfam08415
316401008341	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
316401008342	PS00012 Phosphopantetheine attachment site.
316401008343	PS00256 Adipokinetic hormone family signature.
316401008344	PS00455 Putative AMP-binding domain signature.
316401008345	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
316401008346	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
316401008347	active site
316401008348	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
316401008349	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
316401008350	Methyltransferase domain; Region: Methyltransf_12; pfam08242
316401008351	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
316401008352	KR domain; Region: KR; pfam08659
316401008353	NADP binding site [chemical binding]; other site
316401008354	active site
316401008355	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
316401008356	Condensation domain; Region: Condensation; pfam00668
316401008357	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
316401008358	Nonribosomal peptide synthase; Region: NRPS; pfam08415
316401008359	Methyltransferase domain; Region: Methyltransf_12; pfam08242
316401008360	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
316401008361	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
316401008362	PS00606 Beta-ketoacyl synthases active site.
316401008363	PS00095 C-5 cytosine-specific DNA methylases C-terminal signature.
316401008364	PS00012 Phosphopantetheine attachment site.
316401008365	PS00012 Phosphopantetheine attachment site.
316401008366	Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693
316401008367	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
316401008368	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
316401008369	PS00435 Peroxidases proximal heme-ligand signature.
316401008370	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
316401008371	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
316401008372	acyl-activating enzyme (AAE) consensus motif; other site
316401008373	active site
316401008374	AMP binding site [chemical binding]; other site
316401008375	substrate binding site [chemical binding]; other site
316401008376	PS00455 Putative AMP-binding domain signature.
316401008377	PS00761 Signal peptidases I signature 3.
316401008378	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
316401008379	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
316401008380	N-terminal plug; other site
316401008381	ligand-binding site [chemical binding]; other site
316401008382	Signal peptide predicted for ETEC2086 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.977 between residues 22 and 23
316401008383	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
316401008384	potential frameshift: common BLAST hit: gi|117624169|ref|YP_853082.1| autotransporter
316401008385	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
316401008386	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
316401008387	Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369
316401008388	Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369
316401008389	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
316401008390	PS00017 ATP/GTP-binding site motif A (P-loop).
316401008391	IS2 transposase TnpB; Reviewed; Region: PRK09409
316401008392	HTH-like domain; Region: HTH_21; pfam13276
316401008393	Integrase core domain; Region: rve; pfam00665
316401008394	Integrase core domain; Region: rve_3; pfam13683
316401008395	IS2 repressor TnpA; Reviewed; Region: PRK09413
316401008396	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
316401008397	Similar to Escherichia coli o6:k15:h31 (strain 536/upec). putative uncharacterized protein. UniProt:Q0TGH7 (EMBL:CP000247 (350 aa) fasta scores: E()=3.8e-75, 96.474% id in 312 aa. An insertion sequence has inserted into the protein, there is also another IS element at the C-terminus of the protein
316401008398	IS1 transposase; Region: DDE_Tnp_IS1; pfam03400
316401008399	shikimate transporter; Provisional; Region: PRK09952
316401008400	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401008401	putative substrate translocation pore; other site
316401008402	12 probable transmembrane helices predicted for ETEC2094 by TMHMM2.0 at aa 25-47, 62-84, 97-119, 129-151, 164-186, 196-215, 255-277, 287-309, 318-337, 341-363, 383-405 and 410-432
316401008403	PS00217 Sugar transport proteins signature 2.
316401008404	AMP nucleosidase; Provisional; Region: PRK08292
316401008405	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
316401008406	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
316401008407	hypothetical protein; Provisional; Region: PRK12378
316401008408	MATE family multidrug exporter; Provisional; Region: PRK10189
316401008409	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
316401008410	11 probable transmembrane helices predicted for ETEC2097 by TMHMM2.0 at aa 49-71, 86-108, 121-140, 160-182, 194-216, 231-253, 266-288, 303-325, 352-374, 389-411 and 434-456
316401008411	transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679
316401008412	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401008413	The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444
316401008414	putative substrate binding site [chemical binding]; other site
316401008415	dimerization interface [polypeptide binding]; other site
316401008416	PS00044 Bacterial regulatory proteins, lysR family signature.
316401008417	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
316401008418	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401008419	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
316401008420	putative dimerization interface [polypeptide binding]; other site
316401008421	PS00044 Bacterial regulatory proteins, lysR family signature.
316401008422	L,D-transpeptidase; Provisional; Region: PRK10190
316401008423	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
316401008424	Signal peptide predicted for ETEC2100 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 21 and 22
316401008425	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
316401008426	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
316401008427	putative dimer interface [polypeptide binding]; other site
316401008428	active site pocket [active]
316401008429	putative cataytic base [active]
316401008430	cobalamin 5'-phosphate synthase/cobalamin synthase; Region: cobS; TIGR00317
316401008431	4 probable transmembrane helices predicted for ETEC2102 by TMHMM2.0 at aa 33-55, 57-79, 109-128 and 185-216
316401008432	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
316401008433	homotrimer interface [polypeptide binding]; other site
316401008434	Walker A motif; other site
316401008435	GTP binding site [chemical binding]; other site
316401008436	Walker B motif; other site
316401008437	PS00017 ATP/GTP-binding site motif A (P-loop).
316401008438	putative transposase OrfB; Reviewed; Region: PHA02517
316401008439	HTH-like domain; Region: HTH_21; pfam13276
316401008440	Integrase core domain; Region: rve; pfam00665
316401008441	Integrase core domain; Region: rve_2; pfam13333
316401008442	Transposase; Region: HTH_Tnp_1; cl17663
316401008443	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
316401008445	Protein of unknown function (DUF3279); Region: DUF3279; pfam11682
316401008447	Protein of unknown function (DUF3296); Region: DUF3296; pfam11726
316401008448	Haemolysin expression modulating protein; Region: HHA; pfam05321
316401008449	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930
316401008450	Predicted GTPase [General function prediction only]; Region: COG3596
316401008451	YfjP GTPase; Region: YfjP; cd11383
316401008452	G1 box; other site
316401008453	GTP/Mg2+ binding site [chemical binding]; other site
316401008454	Switch I region; other site
316401008455	G2 box; other site
316401008456	Switch II region; other site
316401008457	G3 box; other site
316401008458	G4 box; other site
316401008459	G5 box; other site
316401008460	PS00017 ATP/GTP-binding site motif A (P-loop).
316401008461	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
316401008462	Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468
316401008463	hypothetical protein; Provisional; Region: PRK09945
316401008464	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
316401008465	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
316401008466	Autotransporter beta-domain; Region: Autotransporter; smart00869
316401008467	Signal peptide predicted for ETEC2119 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 52 and 53
316401008468	PS00017 ATP/GTP-binding site motif A (P-loop).
316401008469	Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006
316401008470	Domain of unknown function (DUF932); Region: DUF932; pfam06067
316401008471	potential frameshift: common BLAST hit: gi|218697845|ref|YP_002405512.1| antirestriction protein
316401008472	Antirestriction protein; Region: Antirestrict; pfam03230
316401008473	DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003
316401008474	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
316401008475	MPN+ (JAMM) motif; other site
316401008476	Zinc-binding site [ion binding]; other site
316401008477	PS01302 DNA repair protein radC family signature.
316401008478	Protein of unknown function (DUF987); Region: DUF987; pfam06174
316401008479	YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154
316401008480	Protein of unknown function (DUF1219); Region: DUF1219; pfam06755
316401008482	Transposase; Region: HTH_Tnp_1; cl17663
316401008483	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
316401008484	putative transposase OrfB; Reviewed; Region: PHA02517
316401008485	HTH-like domain; Region: HTH_21; pfam13276
316401008486	Integrase core domain; Region: rve; pfam00665
316401008487	Integrase core domain; Region: rve_3; pfam13683
316401008488	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
316401008489	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
316401008490	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
316401008491	Transposase; Region: HTH_Tnp_1; pfam01527
316401008492	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
316401008493	Helix-turn-helix domain; Region: HTH_38; pfam13936
316401008494	Integrase core domain; Region: rve; pfam00665
316401008495	PS01043 Transposases, IS30 family, signature.
316401008496	putative transposase OrfB; Reviewed; Region: PHA02517
316401008497	Integrase core domain; Region: rve; pfam00665
316401008498	Integrase core domain; Region: rve_3; pfam13683
316401008499	Protein of unknown function (DUF1401); Region: DUF1401; pfam07180
316401008500	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
316401008501	DNA binding residues [nucleotide binding]
316401008502	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
316401008503	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
316401008504	hypothetical protein; Provisional; Region: PRK09945
316401008505	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343
316401008506	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
316401008507	Autotransporter beta-domain; Region: Autotransporter; pfam03797
316401008508	Signal peptide predicted for ETEC2141 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.972 between residues 54 and 55
316401008509	1 probable transmembrane helix predicted for ETEC2141 by TMHMM2.0 at aa 37-56
316401008510	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
316401008511	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
316401008512	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
316401008513	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
316401008514	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
316401008515	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
316401008516	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
316401008517	Transposase; Region: HTH_Tnp_1; pfam01527
316401008518	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
316401008519	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
316401008520	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
316401008521	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
316401008522	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
316401008523	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
316401008524	Transposase; Region: HTH_Tnp_1; pfam01527
316401008525	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
316401008526	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
316401008527	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
316401008528	DNA binding residues [nucleotide binding]
316401008529	Integrase core domain; Region: rve; pfam00665
316401008530	transposase/IS protein; Provisional; Region: PRK09183
316401008531	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316401008532	Walker A motif; other site
316401008533	ATP binding site [chemical binding]; other site
316401008534	Walker B motif; other site
316401008535	PS00017 ATP/GTP-binding site motif A (P-loop).
316401008536	hypothetical protein; Provisional; Region: PRK05423
316401008537	Similar to E.coli yeeA; with=UniProt:P33011 (EMBL:U00096;); Escherichia coli.; yeeA; Inner membrane protein yeeA.; length=352; id 93.750%; ungapped id 97.059%; E()=7.1e-81; 352 aa overlap; query 1-340; subject 1-352. This CDS has been interrupted by an insertion sequence/element
316401008538	Transposase; Region: HTH_Tnp_1; cl17663
316401008539	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
316401008540	putative transposase OrfB; Reviewed; Region: PHA02517
316401008541	HTH-like domain; Region: HTH_21; pfam13276
316401008542	Integrase core domain; Region: rve; pfam00665
316401008543	Integrase core domain; Region: rve_2; pfam13333
316401008544	DNA gyrase inhibitor; Provisional; Region: PRK10016
316401008545	D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397
316401008546	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
316401008547	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
316401008548	Signal peptide predicted for ETEC2153 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.982 between residues 21 and 22
316401008549	exonuclease I; Provisional; Region: sbcB; PRK11779
316401008550	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
316401008551	active site
316401008552	catalytic site [active]
316401008553	substrate binding site [chemical binding]; other site
316401008554	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
316401008555	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
316401008556	CPxP  motif; other site
316401008557	PS01148 Uncharacterized protein family UPF0033 signature.
316401008558	putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112
316401008559	Sulphur transport; Region: Sulf_transp; pfam04143
316401008560	9 probable transmembrane helices predicted for ETEC2156 by TMHMM2.0 at aa 4-21, 42-64, 74-93, 106-123, 151-168, 198-217, 247-266, 287-309 and 319-338
316401008561	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
316401008562	12 probable transmembrane helices predicted for ETEC2157 by TMHMM2.0 at aa 17-36, 51-73, 94-116, 131-149, 156-178, 198-217, 238-260, 287-309, 340-362, 366-383, 396-415 and 420-437
316401008563	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401008564	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
316401008565	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
316401008566	dimerization interface [polypeptide binding]; other site
316401008567	PS00017 ATP/GTP-binding site motif A (P-loop).
316401008568	PS00044 Bacterial regulatory proteins, lysR family signature.
316401008569	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
316401008570	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
316401008571	putative NAD(P) binding site [chemical binding]; other site
316401008572	PS00017 ATP/GTP-binding site motif A (P-loop).
316401008573	Signal peptide predicted for ETEC2159 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.883 between residues 24 and 25
316401008574	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
316401008575	antitoxin YefM; Provisional; Region: PRK11409
316401008576	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
316401008577	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
316401008578	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
316401008579	PS01316 ATP phosphoribosyltransferase signature.
316401008580	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
316401008581	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
316401008582	NAD binding site [chemical binding]; other site
316401008583	dimerization interface [polypeptide binding]; other site
316401008584	product binding site; other site
316401008585	substrate binding site [chemical binding]; other site
316401008586	zinc binding site [ion binding]; other site
316401008587	catalytic residues [active]
316401008588	PS00611 Histidinol dehydrogenase signature.
316401008589	histidinol-phosphate aminotransferase; Provisional; Region: PRK01688
316401008590	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
316401008591	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316401008592	homodimer interface [polypeptide binding]; other site
316401008593	catalytic residue [active]
316401008594	PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site.
316401008595	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
316401008596	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
316401008597	active site
316401008598	motif I; other site
316401008599	motif II; other site
316401008600	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
316401008601	putative active site pocket [active]
316401008602	4-fold oligomerization interface [polypeptide binding]; other site
316401008603	metal binding residues [ion binding]; metal-binding site
316401008604	3-fold/trimer interface [polypeptide binding]; other site
316401008605	PS00954 Imidazoleglycerol-phosphate dehydratase signature 1.
316401008606	PS00955 Imidazoleglycerol-phosphate dehydratase signature 2.
316401008607	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170
316401008608	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
316401008609	putative active site [active]
316401008610	oxyanion strand; other site
316401008611	catalytic triad [active]
316401008612	PS00136 Serine proteases, subtilase family, aspartic acid active site.
316401008613	PS00442 Glutamine amidotransferases class-I active site.
316401008614	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
316401008615	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
316401008616	catalytic residues [active]
316401008617	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
316401008618	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
316401008619	substrate binding site [chemical binding]; other site
316401008620	glutamase interaction surface [polypeptide binding]; other site
316401008621	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
316401008622	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
316401008623	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
316401008624	metal binding site [ion binding]; metal-binding site
316401008625	PS00430 TonB-dependent receptor proteins signature 1.
316401008626	chain length determinant protein WzzB; Provisional; Region: PRK15471
316401008627	Chain length determinant protein; Region: Wzz; pfam02706
316401008628	2 probable transmembrane helices predicted for ETEC2171 by TMHMM2.0 at aa 32-51 and 296-315
316401008629	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
316401008630	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
316401008631	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
316401008632	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
316401008633	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
316401008634	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
316401008635	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
316401008636	PS00461 6-phosphogluconate dehydrogenase signature.
316401008637	14 probable transmembrane helices predicted for ETEC2174 by TMHMM2.0 at aa 7-29, 44-66, 87-106, 110-132, 145-162, 172-194, 215-237, 247-269, 290-312, 327-349, 362-379, 383-400, 419-436 and 441-463
316401008638	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
316401008639	active site
316401008640	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
316401008641	substrate binding site [chemical binding]; other site
316401008642	PS00109 Tyrosine protein kinases specific active-site signature.
316401008643	capsule biosynthesis phosphatase; Region: EcbF-BcbF; TIGR01689
316401008644	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
316401008645	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
316401008646	WavE lipopolysaccharide synthesis; Region: WavE; pfam07507
316401008647	phosphomannomutase CpsG; Provisional; Region: PRK15414
316401008648	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
316401008649	active site
316401008650	substrate binding site [chemical binding]; other site
316401008651	metal binding site [ion binding]; metal-binding site
316401008652	PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature.
316401008653	mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460
316401008654	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
316401008655	Substrate binding site; other site
316401008656	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
316401008657	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
316401008658	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795
316401008659	putative ADP-binding pocket [chemical binding]; other site
316401008660	1 probable transmembrane helix predicted for ETEC2183 by TMHMM2.0 at aa 51-73
316401008661	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
316401008662	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
316401008663	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
316401008664	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
316401008665	active site
316401008666	tetramer interface; other site
316401008667	Signal peptide predicted for ETEC2185 by SignalP 2.0 HMM (Signal peptide probability 0.742) with cleavage site probability 0.700 between residues 22 and 23
316401008668	putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123
316401008669	Signal peptide predicted for ETEC2186 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.826 between residues 28 and 29
316401008670	colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005
316401008671	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
316401008672	putative ADP-binding pocket [chemical binding]; other site
316401008673	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
316401008674	colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006
316401008675	colanic acid exporter; Provisional; Region: PRK10459
316401008676	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
316401008677	12 probable transmembrane helices predicted for ETEC2189 by TMHMM2.0 at aa 13-35, 45-67, 80-102, 156-178, 199-218, 233-255, 284-306, 326-348, 355-377, 381-403, 416-438 and 448-467
316401008678	PS00287 Cysteine proteases inhibitors signature.
316401008679	putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124
316401008680	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
316401008681	5 probable transmembrane helices predicted for ETEC2190 by TMHMM2.0 at aa 12-34, 44-66, 79-101, 111-130 and 279-300
316401008682	PS01047 Heavy-metal-associated domain.
316401008683	phosphomannomutase CpsG; Provisional; Region: PRK15414
316401008684	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
316401008685	active site
316401008686	substrate binding site [chemical binding]; other site
316401008687	metal binding site [ion binding]; metal-binding site
316401008688	PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature.
316401008689	mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460
316401008690	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
316401008691	Substrate binding site; other site
316401008692	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
316401008693	colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007
316401008694	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
316401008695	GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430
316401008696	active site
316401008697	GDP-Mannose binding site [chemical binding]; other site
316401008698	dimer interface [polypeptide binding]; other site
316401008699	modified nudix motif
316401008700	metal binding site [ion binding]; metal-binding site
316401008701	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
316401008702	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
316401008703	NADP binding site [chemical binding]; other site
316401008704	active site
316401008705	putative substrate binding site [chemical binding]; other site
316401008706	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
316401008707	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
316401008708	NADP-binding site; other site
316401008709	homotetramer interface [polypeptide binding]; other site
316401008710	substrate binding site [chemical binding]; other site
316401008711	homodimer interface [polypeptide binding]; other site
316401008712	active site
316401008713	PS00061 Short-chain dehydrogenases/reductases family signature.
316401008714	colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008
316401008715	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
316401008716	putative trimer interface [polypeptide binding]; other site
316401008717	putative active site [active]
316401008718	putative substrate binding site [chemical binding]; other site
316401008719	putative CoA binding site [chemical binding]; other site
316401008720	PS00101 Hexapeptide-repeat containing-transferases signature.
316401008721	PS00095 C-5 cytosine-specific DNA methylases C-terminal signature.
316401008722	putative glycosyl transferase; Provisional; Region: PRK10063
316401008723	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
316401008724	metal-binding site
316401008725	putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010
316401008726	11 probable transmembrane helices predicted for ETEC2199 by TMHMM2.0 at aa 7-25, 30-47, 54-76, 81-103, 115-137, 172-191, 203-225, 245-264, 277-299, 326-348 and 369-391
316401008727	colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015
316401008728	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
316401008729	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
316401008730	putative acyl transferase; Provisional; Region: PRK10191
316401008731	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
316401008732	trimer interface [polypeptide binding]; other site
316401008733	active site
316401008734	substrate binding site [chemical binding]; other site
316401008735	CoA binding site [chemical binding]; other site
316401008736	PS00101 Hexapeptide-repeat containing-transferases signature.
316401008737	putative glycosyl transferase; Provisional; Region: PRK10018
316401008738	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
316401008739	active site
316401008740	tyrosine kinase; Provisional; Region: PRK11519
316401008741	Chain length determinant protein; Region: Wzz; pfam02706
316401008742	Chain length determinant protein; Region: Wzz; cl15801
316401008743	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
316401008744	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
316401008745	2 probable transmembrane helices predicted for ETEC2203 by TMHMM2.0 at aa 32-54 and 427-449
316401008746	Low molecular weight phosphatase family; Region: LMWPc; cd00115
316401008747	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
316401008748	active site
316401008749	polysaccharide export protein Wza; Provisional; Region: PRK15078
316401008750	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
316401008751	SLBB domain; Region: SLBB; pfam10531
316401008752	Signal peptide predicted for ETEC2205 by SignalP 2.0 HMM (Signal peptide probability 0.983) with cleavage site probability 0.839 between residues 33 and 34
316401008753	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401008754	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
316401008755	FOG: CBS domain [General function prediction only]; Region: COG0517
316401008756	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
316401008757	Transporter associated domain; Region: CorC_HlyC; smart01091
316401008758	7 probable transmembrane helices predicted for ETEC2206 by TMHMM2.0 at aa 13-35, 48-70, 80-99, 126-148, 153-172, 185-207 and 212-234
316401008759	putative assembly protein; Provisional; Region: PRK10833
316401008760	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
316401008761	Signal peptide predicted for ETEC2207 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.440 between residues 26 and 27
316401008762	1 probable transmembrane helix predicted for ETEC2207 by TMHMM2.0 at aa 7-26
316401008763	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
316401008764	trimer interface [polypeptide binding]; other site
316401008765	active site
316401008766	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
316401008767	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
316401008768	ATP-binding site [chemical binding]; other site
316401008769	Sugar specificity; other site
316401008770	Pyrimidine base specificity; other site
316401008771	PS00430 TonB-dependent receptor proteins signature 1.
316401008772	PS00017 ATP/GTP-binding site motif A (P-loop).
316401008773	Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447
316401008774	putative diguanylate cyclase; Provisional; Region: PRK09776
316401008775	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316401008776	putative active site [active]
316401008777	heme pocket [chemical binding]; other site
316401008778	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316401008779	putative active site [active]
316401008780	heme pocket [chemical binding]; other site
316401008781	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316401008782	putative active site [active]
316401008783	heme pocket [chemical binding]; other site
316401008784	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316401008785	metal binding site [ion binding]; metal-binding site
316401008786	active site
316401008787	I-site; other site
316401008788	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
316401008789	11 probable transmembrane helices predicted for ETEC2210 by TMHMM2.0 at aa 7-29, 39-58, 65-84, 89-111, 124-146, 156-177, 190-207, 211-228, 235-252, 267-289 and 387-409
316401008790	3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308
316401008791	AlkA N-terminal domain; Region: AlkA_N; smart01009
316401008792	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
316401008793	minor groove reading motif; other site
316401008794	helix-hairpin-helix signature motif; other site
316401008795	substrate binding pocket [chemical binding]; other site
316401008796	active site
316401008797	PS00516 Alkylbase DNA glycosidases alkA family signature.
316401008798	putative chaperone; Provisional; Region: PRK11678
316401008799	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
316401008800	nucleotide binding site [chemical binding]; other site
316401008801	putative NEF/HSP70 interaction site [polypeptide binding]; other site
316401008802	SBD interface [polypeptide binding]; other site
316401008803	PS00329 Heat shock hsp70 proteins family signature 2.
316401008804	Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248
316401008805	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
316401008806	substrate binding site [chemical binding]; other site
316401008807	activation loop (A-loop); other site
316401008808	Y-family of DNA polymerases; Region: PolY; cl12025
316401008809	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779
316401008810	Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077
316401008811	Signal peptide predicted for ETEC2214 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.651 between residues 19 and 20
316401008812	Protein phosphatase 2C; Region: PP2C_2; pfam13672
316401008813	VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464
316401008814	metal ion-dependent adhesion site (MIDAS); other site
316401008815	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
316401008816	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
316401008817	HlyD family secretion protein; Region: HlyD_3; pfam13437
316401008818	1 probable transmembrane helix predicted for ETEC2217 by TMHMM2.0 at aa 7-26
316401008819	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
316401008820	Protein export membrane protein; Region: SecD_SecF; cl14618
316401008821	11 probable transmembrane helices predicted for ETEC2218 by TMHMM2.0 at aa 15-37, 345-362, 367-389, 396-418, 438-460, 472-494, 535-557, 867-889, 909-931, 968-990 and 1000-1022
316401008822	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
316401008823	10 probable transmembrane helices predicted for ETEC2219 by TMHMM2.0 at aa 7-29, 336-353, 360-379, 389-411, 431-453, 468-490, 853-875, 895-917, 948-970 and 985-1007
316401008824	putative transporter; Provisional; Region: PRK10504
316401008825	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401008826	putative substrate translocation pore; other site
316401008827	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401008828	13 probable transmembrane helices predicted for ETEC2220 by TMHMM2.0 at aa 12-34, 47-69, 76-98, 102-124, 136-158, 163-185, 197-214, 224-243, 263-282, 286-308, 329-351, 396-418 and 431-453
316401008829	signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549
316401008830	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
316401008831	dimerization interface [polypeptide binding]; other site
316401008832	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316401008833	dimer interface [polypeptide binding]; other site
316401008834	phosphorylation site [posttranslational modification]
316401008835	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316401008836	ATP binding site [chemical binding]; other site
316401008837	Mg2+ binding site [ion binding]; other site
316401008838	G-X-G motif; other site
316401008839	2 probable transmembrane helices predicted for ETEC2221 by TMHMM2.0 at aa 13-35 and 168-190
316401008840	DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710
316401008841	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316401008842	active site
316401008843	phosphorylation site [posttranslational modification]
316401008844	intermolecular recognition site; other site
316401008845	dimerization interface [polypeptide binding]; other site
316401008846	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
316401008847	DNA binding site [nucleotide binding]
316401008848	PS00294 Prenyl group binding site (CAAX box).
316401008849	Uncharacterized conserved protein [Function unknown]; Region: COG3422
316401008850	Domain of unknown function (DUF1508); Region: DUF1508; pfam07411
316401008851	putative protease; Provisional; Region: PRK15452
316401008852	Peptidase family U32; Region: Peptidase_U32; pfam01136
316401008853	PS01276 Peptidase family U32 signature.
316401008854	Signal peptide predicted for ETEC2225 by SignalP 2.0 HMM (Signal peptide probability 0.987) with cleavage site probability 0.759 between residues 22 and 23
316401008855	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401008856	lipid kinase; Reviewed; Region: PRK13054
316401008857	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
316401008860	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
316401008861	N- and C-terminal domain interface [polypeptide binding]; other site
316401008862	D-xylulose kinase; Region: XylB; TIGR01312
316401008863	active site
316401008864	MgATP binding site [chemical binding]; other site
316401008865	catalytic site [active]
316401008866	metal binding site [ion binding]; metal-binding site
316401008867	xylulose binding site [chemical binding]; other site
316401008868	homodimer interface [polypeptide binding]; other site
316401008869	PS00933 FGGY family of carbohydrate kinases signature 1.
316401008870	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
316401008871	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
316401008872	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
316401008873	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
316401008874	helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419
316401008875	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
316401008876	Transcriptional regulators [Transcription]; Region: PurR; COG1609
316401008877	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
316401008878	DNA binding site [nucleotide binding]
316401008879	domain linker motif; other site
316401008880	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
316401008881	dimerization interface [polypeptide binding]; other site
316401008882	ligand binding site [chemical binding]; other site
316401008883	PS00356 Bacterial regulatory proteins, lacI family signature.
316401008884	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
316401008885	classical (c) SDRs; Region: SDR_c; cd05233
316401008886	NAD(P) binding site [chemical binding]; other site
316401008887	active site
316401008888	PS00061 Short-chain dehydrogenases/reductases family signature.
316401008889	Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782
316401008890	FGGY-family pentulose kinase; Region: 5C_CHO_kinase; TIGR01315
316401008891	N- and C-terminal domain interface [polypeptide binding]; other site
316401008892	active site
316401008893	MgATP binding site [chemical binding]; other site
316401008894	catalytic site [active]
316401008895	metal binding site [ion binding]; metal-binding site
316401008896	carbohydrate binding site [chemical binding]; other site
316401008897	putative homodimer interface [polypeptide binding]; other site
316401008898	polyol permease family; Region: 2A0118; TIGR00897
316401008899	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401008900	putative substrate translocation pore; other site
316401008901	12 probable transmembrane helices predicted for ETEC2235 by TMHMM2.0 at aa 13-35, 50-72, 81-103, 108-130, 142-164, 174-196, 231-253, 263-285, 292-311, 321-343, 356-378 and 382-404
316401008902	PS00225 Crystallins beta and gamma 'Greek key' motif signature.
316401008903	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
316401008904	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
316401008905	putative active site; other site
316401008906	catalytic residue [active]
316401008907	nucleoside transporter; Region: 2A0110; TIGR00889
316401008908	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401008909	putative substrate translocation pore; other site
316401008910	12 probable transmembrane helices predicted for ETEC2237 by TMHMM2.0 at aa 7-29, 39-61, 70-87, 97-119, 132-154, 159-181, 211-233, 243-265, 274-291, 301-323, 336-358 and 378-400
316401008911	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
316401008912	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
316401008913	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
316401008914	substrate binding site [chemical binding]; other site
316401008915	ATP binding site [chemical binding]; other site
316401008916	PS00583 pfkB family of carbohydrate kinases signature 1.
316401008917	PS00584 pfkB family of carbohydrate kinases signature 2.
316401008918	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
316401008919	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
316401008920	DNA-binding site [nucleotide binding]; DNA binding site
316401008921	UTRA domain; Region: UTRA; pfam07702
316401008922	Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757
316401008923	YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524
316401008924	active site
316401008925	1 probable transmembrane helix predicted for ETEC2241 by TMHMM2.0 at aa 13-32
316401008926	Signal peptide predicted for ETEC2241 by SignalP 2.0 HMM (Signal peptide probability 0.914) with cleavage site probability 0.526 between residues 24 and 25
316401008927	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
316401008928	dimer interface [polypeptide binding]; other site
316401008929	substrate binding site [chemical binding]; other site
316401008930	ATP binding site [chemical binding]; other site
316401008931	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
316401008932	substrate binding site [chemical binding]; other site
316401008933	multimerization interface [polypeptide binding]; other site
316401008934	ATP binding site [chemical binding]; other site
316401008935	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
316401008936	putative metal binding site [ion binding]; other site
316401008937	putative homodimer interface [polypeptide binding]; other site
316401008938	putative homotetramer interface [polypeptide binding]; other site
316401008939	putative homodimer-homodimer interface [polypeptide binding]; other site
316401008940	putative allosteric switch controlling residues; other site
316401008941	nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019
316401008942	Predicted integral membrane protein [Function unknown]; Region: COG5455
316401008943	1 probable transmembrane helix predicted for ETEC2245 by TMHMM2.0 at aa 7-29
316401008944	putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252
316401008945	putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216
316401008946	Signal peptide predicted for ETEC2246 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.900 between residues 20 and 21
316401008947	fimbrial outer membrane usher protein; Provisional; Region: PRK15217
316401008948	PapC N-terminal domain; Region: PapC_N; pfam13954
316401008949	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
316401008950	PapC C-terminal domain; Region: PapC_C; pfam13953
316401008951	PS01151 Fimbrial biogenesis outer membrane usher protein signature.
316401008952	Signal peptide predicted for ETEC2247 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.968 between residues 22 and 23
316401008953	putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253
316401008954	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
316401008955	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
316401008956	PS00635 Gram-negative pili assembly chaperone signature.
316401008957	1 probable transmembrane helix predicted for ETEC2248 by TMHMM2.0 at aa 20-42
316401008958	Signal peptide predicted for ETEC2248 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 33 and 34
316401008959	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
316401008960	1 probable transmembrane helix predicted for ETEC2249 by TMHMM2.0 at aa 5-23
316401008961	Signal peptide predicted for ETEC2249 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 22 and 23
316401008962	Protein of unknown function (DUF2574); Region: DUF2574; pfam10836
316401008963	Signal peptide predicted for ETEC2250 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.981 between residues 22 and 23
316401008964	antiporter inner membrane protein; Provisional; Region: PRK11670
316401008965	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
316401008966	Walker A motif; other site
316401008967	PS01215 Mrp family signature.
316401008968	PS00017 ATP/GTP-binding site motif A (P-loop).
316401008969	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
316401008970	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
316401008971	active site
316401008972	HIGH motif; other site
316401008973	KMSKS motif; other site
316401008974	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
316401008975	tRNA binding surface [nucleotide binding]; other site
316401008976	anticodon binding site; other site
316401008977	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
316401008978	dimer interface [polypeptide binding]; other site
316401008979	putative tRNA-binding site [nucleotide binding]; other site
316401008980	PS00178 Aminoacyl-transfer RNA synthetases class-I signature.
316401008981	Similar to Escherichia coli MolR molybdate metabolism regulator. UniProt:P33345 (1264 aa) fasta scores: E()=1.7e-125, 96.524% id in 633 aa, and to ) escherichia coli b. wgr domain protein. UniProt:A2UE17 (EMBL:AAWW01000003 (1264 aa) fasta scores: E()=7.2e-128, 97.156% id in 633 aa. This CDS has been interrupted by an insertion sequence
316401008982	IS1 transposase; Region: DDE_Tnp_IS1; pfam03400
316401008983	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
316401008984	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
316401008985	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
316401008986	PS00017 ATP/GTP-binding site motif A (P-loop).
316401008987	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
316401008988	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
316401008989	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
316401008990	PS00017 ATP/GTP-binding site motif A (P-loop).
316401008991	IS1 transposase; Region: DDE_Tnp_IS1; pfam03400
316401008992	Similar to C-terminus of Shigella dysenteriae serotype 1 (strain sd197). putative uncharacterized protein. UniProt:Q32EK2 (EMBL:CP000034 (323 aa) fasta scores: E()=2.5e-78, 96.585% id in 205 aa
316401008993	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808
316401008994	Signal peptide predicted for ETEC2259 by SignalP 2.0 HMM (Signal peptide probability 0.987) with cleavage site probability 0.461 between residues 24 and 25
316401008995	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401008996	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
316401008997	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316401008998	active site
316401008999	phosphorylation site [posttranslational modification]
316401009000	intermolecular recognition site; other site
316401009001	dimerization interface [polypeptide binding]; other site
316401009002	LytTr DNA-binding domain; Region: LytTR; pfam04397
316401009003	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
316401009004	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
316401009005	GAF domain; Region: GAF; pfam01590
316401009006	Histidine kinase; Region: His_kinase; pfam06580
316401009007	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316401009008	ATP binding site [chemical binding]; other site
316401009009	Mg2+ binding site [ion binding]; other site
316401009010	G-X-G motif; other site
316401009011	6 probable transmembrane helices predicted for ETEC2261 by TMHMM2.0 at aa 4-23, 44-63, 73-95, 107-129, 139-161 and 168-190
316401009012	transcriptional regulator MirA; Provisional; Region: PRK15043
316401009013	Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763
316401009014	DNA binding residues [nucleotide binding]
316401009015	PS00552 Bacterial regulatory proteins, merR family signature.
316401009016	hypothetical protein; Provisional; Region: PRK13681
316401009017	Signal peptide predicted for ETEC2263 by SignalP 2.0 HMM (Signal peptide probability 0.977) with cleavage site probability 0.779 between residues 25 and 26
316401009018	1 probable transmembrane helix predicted for ETEC2263 by TMHMM2.0 at aa 7-29
316401009019	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
316401009020	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401009021	dimer interface [polypeptide binding]; other site
316401009022	conserved gate region; other site
316401009023	putative PBP binding loops; other site
316401009024	ABC-ATPase subunit interface; other site
316401009025	6 probable transmembrane helices predicted for ETEC2264 by TMHMM2.0 at aa 7-29, 49-71, 92-114, 118-140, 164-186 and 201-223
316401009026	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
316401009027	Signal peptide predicted for ETEC2264 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.999 between residues 30 and 31
316401009028	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
316401009029	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
316401009030	Walker A/P-loop; other site
316401009031	ATP binding site [chemical binding]; other site
316401009032	Q-loop/lid; other site
316401009033	ABC transporter signature motif; other site
316401009034	Walker B; other site
316401009035	D-loop; other site
316401009036	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
316401009037	H-loop/switch region; other site
316401009038	PS00211 ABC transporters family signature.
316401009039	PS00017 ATP/GTP-binding site motif A (P-loop).
316401009040	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401009041	dimer interface [polypeptide binding]; other site
316401009042	conserved gate region; other site
316401009043	ABC-ATPase subunit interface; other site
316401009044	10 probable transmembrane helices predicted for ETEC2266 by TMHMM2.0 at aa 7-29, 44-66, 71-90, 100-122, 135-157, 182-204, 211-233, 248-270, 324-346 and 356-378
316401009045	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
316401009046	Signal peptide predicted for ETEC2266 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.662 between residues 22 and 23
316401009047	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
316401009048	Signal peptide predicted for ETEC2267 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 23 and 24
316401009049	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
316401009050	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
316401009051	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
316401009052	PS00775 Glycosyl hydrolases family 3 active site.
316401009053	Signal peptide predicted for ETEC2268 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 20 and 21
316401009054	D-lactate dehydrogenase; Provisional; Region: PRK11183
316401009055	FAD binding domain; Region: FAD_binding_4; pfam01565
316401009056	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
316401009057	PS00290 Immunoglobulins and major histocompatibility complex proteins signature.
316401009058	D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669
316401009059	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
316401009060	Signal peptide predicted for ETEC2270 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.959 between residues 25 and 26
316401009061	Protein of unknown function (DUF1282); Region: DUF1282; pfam06930
316401009062	5 probable transmembrane helices predicted for ETEC2271 by TMHMM2.0 at aa 33-55, 65-87, 108-130, 135-157 and 170-192
316401009063	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
316401009064	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
316401009065	4 probable transmembrane helices predicted for ETEC2272 by TMHMM2.0 at aa 12-34, 44-63, 131-153 and 163-180
316401009066	oxidoreductase; Provisional; Region: PRK12743
316401009067	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
316401009068	NAD(P) binding site [chemical binding]; other site
316401009069	active site
316401009070	PS00061 Short-chain dehydrogenases/reductases family signature.
316401009071	multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459
316401009072	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
316401009073	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
316401009074	FMN binding site [chemical binding]; other site
316401009075	active site
316401009076	catalytic residues [active]
316401009077	substrate binding site [chemical binding]; other site
316401009078	PS01136 Uncharacterized protein family UPF0034 signature.
316401009079	hypothetical protein; Provisional; Region: PRK01821
316401009080	4 probable transmembrane helices predicted for ETEC2276 by TMHMM2.0 at aa 7-29, 33-55, 67-86 and 91-113
316401009081	hypothetical protein; Provisional; Region: PRK10711
316401009082	6 probable transmembrane helices predicted for ETEC2277 by TMHMM2.0 at aa 5-23, 30-52, 90-112, 119-141, 145-167 and 206-228
316401009083	cytidine deaminase; Provisional; Region: PRK09027
316401009084	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
316401009085	active site
316401009086	catalytic motif [active]
316401009087	Zn binding site [ion binding]; other site
316401009088	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
316401009089	active site
316401009090	catalytic motif [active]
316401009091	Zn binding site [ion binding]; other site
316401009092	PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature.
316401009093	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
316401009094	putative active site [active]
316401009095	Signal peptide predicted for ETEC2279 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.980 between residues 22 and 23
316401009096	1 probable transmembrane helix predicted for ETEC2279 by TMHMM2.0 at aa 5-27
316401009097	Protein of unknown function (DUF2542); Region: DUF2542; pfam10808
316401009098	2 probable transmembrane helices predicted for ETEC2280 by TMHMM2.0 at aa 7-24 and 55-77
316401009099	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
316401009100	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
316401009101	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
316401009102	PS00190 Cytochrome c family heme-binding site signature.
316401009103	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
316401009104	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
316401009105	homodimer interface [polypeptide binding]; other site
316401009106	active site
316401009107	FMN binding site [chemical binding]; other site
316401009108	substrate binding site [chemical binding]; other site
316401009109	4Fe-4S binding domain; Region: Fer4; pfam00037
316401009110	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401009111	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
316401009112	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
316401009113	TM-ABC transporter signature motif; other site
316401009114	9 probable transmembrane helices predicted for ETEC2283 by TMHMM2.0 at aa 20-42, 49-68, 100-122, 127-149, 179-201, 222-244, 259-281, 286-308 and 312-330
316401009115	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
316401009116	galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982
316401009117	Walker A/P-loop; other site
316401009118	ATP binding site [chemical binding]; other site
316401009119	Q-loop/lid; other site
316401009120	ABC transporter signature motif; other site
316401009121	Walker B; other site
316401009122	D-loop; other site
316401009123	H-loop/switch region; other site
316401009124	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
316401009125	PS00211 ABC transporters family signature.
316401009126	PS00017 ATP/GTP-binding site motif A (P-loop).
316401009127	methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395
316401009128	Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539
316401009129	ligand binding site [chemical binding]; other site
316401009130	calcium binding site [ion binding]; other site
316401009131	1 probable transmembrane helix predicted for ETEC2285 by TMHMM2.0 at aa 5-24
316401009132	Signal peptide predicted for ETEC2285 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 23 and 24
316401009133	DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401
316401009134	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
316401009135	DNA binding site [nucleotide binding]
316401009136	domain linker motif; other site
316401009137	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
316401009138	dimerization interface (closed form) [polypeptide binding]; other site
316401009139	ligand binding site [chemical binding]; other site
316401009140	PS00356 Bacterial regulatory proteins, lacI family signature.
316401009141	Predicted membrane protein [Function unknown]; Region: COG2311
316401009142	hypothetical protein; Provisional; Region: PRK10835
316401009143	10 probable transmembrane helices predicted for ETEC2287 by TMHMM2.0 at aa 12-34, 49-71, 83-102, 107-123, 130-152, 199-221, 234-253, 273-295, 308-327 and 337-359
316401009144	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
316401009145	homodecamer interface [polypeptide binding]; other site
316401009146	GTP cyclohydrolase I; Provisional; Region: PLN03044
316401009147	active site
316401009148	putative catalytic site residues [active]
316401009149	zinc binding site [ion binding]; other site
316401009150	GTP-CH-I/GFRP interaction surface; other site
316401009151	PS00860 GTP cyclohydrolase I signature 2.
316401009152	PS00859 GTP cyclohydrolase I signature 1.
316401009153	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
316401009154	S-formylglutathione hydrolase; Region: PLN02442
316401009155	catecholate siderophore receptor CirA; Provisional; Region: PRK10064
316401009156	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
316401009157	N-terminal plug; other site
316401009158	ligand-binding site [chemical binding]; other site
316401009159	PS01156 TonB-dependent receptor proteins signature 2.
316401009160	PS00430 TonB-dependent receptor proteins signature 1.
316401009161	Signal peptide predicted for ETEC2290 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.990 between residues 25 and 26
316401009162	lysine transporter; Provisional; Region: PRK10836
316401009163	12 probable transmembrane helices predicted for ETEC2291 by TMHMM2.0 at aa 21-43, 53-75, 103-125, 130-152, 159-181, 196-218, 245-267, 287-309, 343-365, 370-392, 413-435 and 445-467
316401009164	PS00218 Amino acid permeases signature.
316401009165	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
316401009166	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401009167	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
316401009168	putative dimerization interface [polypeptide binding]; other site
316401009169	PS00044 Bacterial regulatory proteins, lysR family signature.
316401009170	conserved hypothetical integral membrane protein; Region: TIGR00698
316401009171	Signal peptide predicted for ETEC2293 by SignalP 2.0 HMM (Signal peptide probability 0.991) with cleavage site probability 0.863 between residues 40 and 41
316401009172	8 probable transmembrane helices predicted for ETEC2293 by TMHMM2.0 at aa 13-32, 36-58, 100-122, 132-151, 163-185, 262-283, 290-312 and 322-344
316401009173	endonuclease IV; Provisional; Region: PRK01060
316401009174	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
316401009175	AP (apurinic/apyrimidinic) site pocket; other site
316401009176	DNA interaction; other site
316401009177	Metal-binding active site; metal-binding site
316401009178	PS00729 AP endonucleases family 2 signature 1.
316401009179	PS00730 AP endonucleases family 2 signature 2.
316401009180	PS00731 AP endonucleases family 2 signature 3.
316401009181	putative kinase; Provisional; Region: PRK09954
316401009182	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
316401009183	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
316401009184	substrate binding site [chemical binding]; other site
316401009185	ATP binding site [chemical binding]; other site
316401009186	PS00583 pfkB family of carbohydrate kinases signature 1.
316401009187	PS00584 pfkB family of carbohydrate kinases signature 2.
316401009188	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
316401009189	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
316401009190	Nucleoside recognition; Region: Gate; pfam07670
316401009191	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
316401009192	8 probable transmembrane helices predicted for ETEC2296 by TMHMM2.0 at aa 5-22, 27-49, 96-118, 173-195, 199-221, 258-280, 355-377 and 390-412
316401009193	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
316401009194	active site
316401009195	tetramer interface [polypeptide binding]; other site
316401009196	PS01247 Inosine-uridine preferring nucleoside hydrolase family signature.
316401009197	DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402
316401009198	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
316401009199	ligand binding site [chemical binding]; other site
316401009200	flexible hinge region; other site
316401009201	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
316401009202	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
316401009203	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
316401009204	Nucleoside recognition; Region: Gate; pfam07670
316401009205	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
316401009206	8 probable transmembrane helices predicted for ETEC2299 by TMHMM2.0 at aa 5-22, 27-49, 96-118, 173-195, 258-280, 287-309, 355-377 and 390-412
316401009207	Signal peptide predicted for ETEC2299 by SignalP 2.0 HMM (Signal peptide probability 0.674) with cleavage site probability 0.534 between residues 24 and 25
316401009208	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
316401009209	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
316401009210	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
316401009211	substrate binding site [chemical binding]; other site
316401009212	ATP binding site [chemical binding]; other site
316401009213	PS00584 pfkB family of carbohydrate kinases signature 2.
316401009214	PS00583 pfkB family of carbohydrate kinases signature 1.
316401009215	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
316401009216	N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925
316401009217	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
316401009218	active site
316401009219	P-loop; other site
316401009220	phosphorylation site [posttranslational modification]
316401009221	PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427
316401009222	9 probable transmembrane helices predicted for ETEC2302 by TMHMM2.0 at aa 237-259, 272-294, 304-326, 346-368, 378-400, 413-435, 465-482, 489-509 and 529-551
316401009223	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
316401009224	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
316401009225	putative substrate binding site [chemical binding]; other site
316401009226	putative ATP binding site [chemical binding]; other site
316401009227	PS00584 pfkB family of carbohydrate kinases signature 2.
316401009228	PS00583 pfkB family of carbohydrate kinases signature 1.
316401009229	PS00464 Ribosomal protein L22 signature.
316401009230	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109
316401009231	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
316401009232	active site
316401009233	phosphorylation site [posttranslational modification]
316401009234	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
316401009235	dimerization domain swap beta strand [polypeptide binding]; other site
316401009236	regulatory protein interface [polypeptide binding]; other site
316401009237	active site
316401009238	regulatory phosphorylation site [posttranslational modification]; other site
316401009239	PS00589 PTS HPR component serine phosphorylation site signature.
316401009240	PS00369 PTS HPR component histidine phosphorylation site signature.
316401009241	PS00372 PTS EIIA domains phosphorylation site signature 2.
316401009242	sugar efflux transporter B; Provisional; Region: PRK15011
316401009243	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401009244	putative substrate translocation pore; other site
316401009245	Signal peptide predicted for ETEC2306 by SignalP 2.0 HMM (Signal peptide probability 0.862) with cleavage site probability 0.807 between residues 32 and 33
316401009246	12 probable transmembrane helices predicted for ETEC2306 by TMHMM2.0 at aa 13-35, 50-72, 84-101, 105-124, 145-167, 172-194, 222-244, 254-276, 283-302, 307-329, 350-367 and 371-388
316401009247	Flagellin N-methylase; Region: FliB; pfam03692
316401009248	elongation factor P; Provisional; Region: PRK04542
316401009249	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
316401009250	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
316401009251	RNA binding site [nucleotide binding]; other site
316401009252	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
316401009253	RNA binding site [nucleotide binding]; other site
316401009254	PS01275 Elongation factor P signature.
316401009255	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
316401009256	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
316401009257	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
316401009258	PS00974 Mannitol dehydrogenases signature.
316401009259	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
316401009260	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
316401009261	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
316401009262	PS00017 ATP/GTP-binding site motif A (P-loop).
316401009263	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
316401009264	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
316401009265	active site
316401009266	5 probable transmembrane helices predicted for ETEC2311 by TMHMM2.0 at aa 9-31, 62-81, 93-115, 160-182 and 195-212
316401009267	outer membrane lipoprotein; Provisional; Region: spr; PRK10838
316401009268	NlpC/P60 family; Region: NLPC_P60; pfam00877
316401009269	Signal peptide predicted for ETEC2312 by SignalP 2.0 HMM (Signal peptide probability 0.964) with cleavage site probability 0.337 between residues 29 and 30
316401009270	phage resistance protein; Provisional; Region: PRK10551
316401009271	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
316401009272	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
316401009273	Signal peptide predicted for ETEC2313 by SignalP 2.0 HMM (Signal peptide probability 0.614) with cleavage site probability 0.258 between residues 35 and 36
316401009274	2 probable transmembrane helices predicted for ETEC2313 by TMHMM2.0 at aa 12-34 and 236-258
316401009275	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
316401009276	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
316401009277	Signal peptide predicted for ETEC2314 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.911 between residues 19 and 20
316401009278	1 probable transmembrane helix predicted for ETEC2314 by TMHMM2.0 at aa 5-22
316401009279	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
316401009280	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401009281	dimer interface [polypeptide binding]; other site
316401009282	conserved gate region; other site
316401009283	putative PBP binding loops; other site
316401009284	ABC-ATPase subunit interface; other site
316401009285	6 probable transmembrane helices predicted for ETEC2315 by TMHMM2.0 at aa 9-31, 134-156, 169-191, 224-246, 283-305 and 329-348
316401009286	microcin C ABC transporter permease; Provisional; Region: PRK15021
316401009287	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401009288	dimer interface [polypeptide binding]; other site
316401009289	conserved gate region; other site
316401009290	ABC-ATPase subunit interface; other site
316401009291	Signal peptide predicted for ETEC2316 by SignalP 2.0 HMM (Signal peptide probability 0.740) with cleavage site probability 0.726 between residues 42 and 43
316401009292	6 probable transmembrane helices predicted for ETEC2316 by TMHMM2.0 at aa 21-43, 142-164, 177-199, 203-222, 254-276 and 306-328
316401009293	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
316401009294	microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134
316401009295	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
316401009296	Walker A/P-loop; other site
316401009297	ATP binding site [chemical binding]; other site
316401009298	Q-loop/lid; other site
316401009299	ABC transporter signature motif; other site
316401009300	Walker B; other site
316401009301	D-loop; other site
316401009302	H-loop/switch region; other site
316401009303	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
316401009304	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
316401009305	Walker A/P-loop; other site
316401009306	ATP binding site [chemical binding]; other site
316401009307	Q-loop/lid; other site
316401009308	ABC transporter signature motif; other site
316401009309	Walker B; other site
316401009310	D-loop; other site
316401009311	H-loop/switch region; other site
316401009312	PS00017 ATP/GTP-binding site motif A (P-loop).
316401009313	PS00211 ABC transporters family signature.
316401009314	PS00017 ATP/GTP-binding site motif A (P-loop).
316401009315	PS00211 ABC transporters family signature.
316401009316	hypothetical protein; Provisional; Region: PRK11835
316401009317	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401009318	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
316401009319	putative substrate translocation pore; other site
316401009320	12 probable transmembrane helices predicted for ETEC2319 by TMHMM2.0 at aa 7-26, 41-63, 76-98, 102-124, 137-159, 163-185, 219-241, 251-273, 286-305, 310-332, 344-366 and 370-389
316401009321	Signal peptide predicted for ETEC2319 by SignalP 2.0 HMM (Signal peptide probability 0.870) with cleavage site probability 0.504 between residues 25 and 26
316401009322	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
316401009323	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
316401009324	RNA binding surface [nucleotide binding]; other site
316401009325	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
316401009326	active site
316401009327	uracil binding [chemical binding]; other site
316401009328	PS01149 Rsu family of pseudouridine synthase signature.
316401009329	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
316401009330	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
316401009331	ATP binding site [chemical binding]; other site
316401009332	putative Mg++ binding site [ion binding]; other site
316401009333	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
316401009334	nucleotide binding region [chemical binding]; other site
316401009335	ATP-binding site [chemical binding]; other site
316401009336	Ribosomal L40e family; Region: Ribosomal_L40e; cl00671
316401009337	PS00017 ATP/GTP-binding site motif A (P-loop).
316401009338	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
316401009339	5S rRNA interface [nucleotide binding]; other site
316401009340	CTC domain interface [polypeptide binding]; other site
316401009341	L16 interface [polypeptide binding]; other site
316401009342	Nucleoid-associated protein [General function prediction only]; Region: COG3081
316401009343	nucleoid-associated protein NdpA; Validated; Region: PRK00378
316401009344	hypothetical protein; Provisional; Region: PRK13689
316401009345	Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083
316401009346	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
316401009347	Sulfatase; Region: Sulfatase; pfam00884
316401009348	PS00430 TonB-dependent receptor proteins signature 1.
316401009349	5 probable transmembrane helices predicted for ETEC2325 by TMHMM2.0 at aa 21-43, 58-80, 85-103, 135-157 and 169-191
316401009350	Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468
316401009351	hypothetical protein; Provisional; Region: PRK09945
316401009352	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343
316401009353	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
316401009354	Autotransporter beta-domain; Region: Autotransporter; pfam03797
316401009355	transcriptional regulator NarP; Provisional; Region: PRK10403
316401009356	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316401009357	active site
316401009358	phosphorylation site [posttranslational modification]
316401009359	intermolecular recognition site; other site
316401009360	dimerization interface [polypeptide binding]; other site
316401009361	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
316401009362	DNA binding residues [nucleotide binding]
316401009363	dimerization interface [polypeptide binding]; other site
316401009364	PS00622 Bacterial regulatory proteins, luxR family signature.
316401009365	Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088
316401009366	formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370
316401009367	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
316401009368	binding surface
316401009369	TPR motif; other site
316401009370	3 probable transmembrane helices predicted for ETEC2328 by TMHMM2.0 at aa 3-25, 97-119 and 147-169
316401009371	Signal peptide predicted for ETEC2328 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 18 and 19
316401009372	thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412
316401009373	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
316401009374	catalytic residues [active]
316401009375	central insert; other site
316401009376	PS00194 Thioredoxin family active site.
316401009377	Signal peptide predicted for ETEC2329 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.478 between residues 28 and 29
316401009378	1 probable transmembrane helix predicted for ETEC2329 by TMHMM2.0 at aa 5-24
316401009379	c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353
316401009380	15 probable transmembrane helices predicted for ETEC2330 by TMHMM2.0 at aa 10-29, 41-63, 95-114, 121-143, 176-198, 211-233, 248-265, 272-294, 309-331, 351-373, 393-415, 422-444, 448-470, 482-504 and 610-629
316401009381	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165
316401009382	Signal peptide predicted for ETEC2331 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.953 between residues 29 and 30
316401009383	1 probable transmembrane helix predicted for ETEC2331 by TMHMM2.0 at aa 7-29
316401009384	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
316401009385	1 probable transmembrane helix predicted for ETEC2332 by TMHMM2.0 at aa 15-37
316401009386	heme exporter protein CcmC; Region: ccmC; TIGR01191
316401009387	6 probable transmembrane helices predicted for ETEC2333 by TMHMM2.0 at aa 21-43, 63-85, 92-114, 129-148, 155-177 and 204-226
316401009388	heme exporter protein CcmB; Region: ccmB; TIGR01190
316401009389	6 probable transmembrane helices predicted for ETEC2334 by TMHMM2.0 at aa 21-40, 44-66, 97-119, 129-151, 158-180 and 195-217
316401009390	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
316401009391	Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231
316401009392	Walker A/P-loop; other site
316401009393	ATP binding site [chemical binding]; other site
316401009394	Q-loop/lid; other site
316401009395	ABC transporter signature motif; other site
316401009396	Walker B; other site
316401009397	D-loop; other site
316401009398	H-loop/switch region; other site
316401009399	PS00211 ABC transporters family signature.
316401009400	PS00017 ATP/GTP-binding site motif A (P-loop).
316401009401	cytochrome c-type protein NapC; Provisional; Region: PRK10617
316401009402	Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005
316401009403	PS00190 Cytochrome c family heme-binding site signature.
316401009404	PS00190 Cytochrome c family heme-binding site signature.
316401009405	PS00190 Cytochrome c family heme-binding site signature.
316401009406	1 probable transmembrane helix predicted for ETEC2336 by TMHMM2.0 at aa 21-43
316401009407	nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586
316401009408	PS00190 Cytochrome c family heme-binding site signature.
316401009409	PS00190 Cytochrome c family heme-binding site signature.
316401009410	Signal peptide predicted for ETEC2337 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 27 and 28
316401009411	quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477
316401009412	4Fe-4S binding domain; Region: Fer4_5; pfam12801
316401009413	4Fe-4S binding domain; Region: Fer4_6; pfam12837
316401009414	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401009415	4 probable transmembrane helices predicted for ETEC2338 by TMHMM2.0 at aa 30-52, 78-100, 138-160 and 170-192
316401009416	quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476
316401009417	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401009418	Signal peptide predicted for ETEC2339 by SignalP 2.0 HMM (Signal peptide probability 0.717) with cleavage site probability 0.358 between residues 41 and 42
316401009419	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
316401009420	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
316401009421	[4Fe-4S] binding site [ion binding]; other site
316401009422	molybdopterin cofactor binding site; other site
316401009423	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
316401009424	molybdopterin cofactor binding site; other site
316401009425	PS00551 Prokaryotic molybdopterin oxidoreductases signature 1.
316401009426	Signal peptide predicted for ETEC2340 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.977 between residues 31 and 32
316401009427	assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553
316401009428	ferredoxin-type protein; Provisional; Region: PRK10194
316401009429	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401009430	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401009431	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401009432	Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242
316401009433	secondary substrate binding site; other site
316401009434	primary substrate binding site; other site
316401009435	inhibition loop; other site
316401009436	dimerization interface [polypeptide binding]; other site
316401009437	Signal peptide predicted for ETEC2343 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 20 and 21
316401009438	malate:quinone oxidoreductase; Validated; Region: PRK05257
316401009439	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
316401009440	Signal peptide predicted for ETEC2344 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.539 between residues 21 and 22
316401009441	multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522
316401009442	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
316401009443	Walker A/P-loop; other site
316401009444	ATP binding site [chemical binding]; other site
316401009445	Q-loop/lid; other site
316401009446	ABC transporter signature motif; other site
316401009447	Walker B; other site
316401009448	D-loop; other site
316401009449	H-loop/switch region; other site
316401009450	PS00211 ABC transporters family signature.
316401009451	PS00017 ATP/GTP-binding site motif A (P-loop).
316401009452	6 probable transmembrane helices predicted for ETEC2345 by TMHMM2.0 at aa 13-35, 50-72, 122-144, 149-171, 231-253 and 268-290
316401009453	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
316401009455	thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461
316401009456	ApbE family; Region: ApbE; pfam02424
316401009457	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401009458	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
316401009459	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
316401009460	trimer interface [polypeptide binding]; other site
316401009461	eyelet of channel; other site
316401009462	PS00576 General diffusion Gram-negative porins signature.
316401009463	PS00030 Eukaryotic putative RNA-binding region RNP-1 signature.
316401009464	Signal peptide predicted for ETEC2349 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 21 and 22
316401009465	phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618
316401009466	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316401009467	ATP binding site [chemical binding]; other site
316401009468	G-X-G motif; other site
316401009469	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
316401009470	putative binding surface; other site
316401009471	active site
316401009472	Signal peptide predicted for ETEC2350 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.498 between residues 40 and 41
316401009473	1 probable transmembrane helix predicted for ETEC2350 by TMHMM2.0 at aa 21-43
316401009474	transcriptional regulator RcsB; Provisional; Region: PRK10840
316401009475	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316401009476	active site
316401009477	phosphorylation site [posttranslational modification]
316401009478	intermolecular recognition site; other site
316401009479	dimerization interface [polypeptide binding]; other site
316401009480	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
316401009481	DNA binding residues [nucleotide binding]
316401009482	dimerization interface [polypeptide binding]; other site
316401009483	PS00622 Bacterial regulatory proteins, luxR family signature.
316401009484	hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841
316401009485	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316401009486	dimer interface [polypeptide binding]; other site
316401009487	phosphorylation site [posttranslational modification]
316401009488	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316401009489	ATP binding site [chemical binding]; other site
316401009490	Mg2+ binding site [ion binding]; other site
316401009491	G-X-G motif; other site
316401009492	RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456
316401009493	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316401009494	active site
316401009495	phosphorylation site [posttranslational modification]
316401009496	intermolecular recognition site; other site
316401009497	dimerization interface [polypeptide binding]; other site
316401009498	2 probable transmembrane helices predicted for ETEC2352 by TMHMM2.0 at aa 4-26 and 299-318
316401009499	Signal peptide predicted for ETEC2352 by SignalP 2.0 HMM (Signal peptide probability 0.867) with cleavage site probability 0.313 between residues 16 and 17
316401009500	sensory histidine kinase AtoS; Provisional; Region: PRK11360
316401009501	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316401009502	putative active site [active]
316401009503	heme pocket [chemical binding]; other site
316401009504	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316401009505	dimer interface [polypeptide binding]; other site
316401009506	phosphorylation site [posttranslational modification]
316401009507	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316401009508	ATP binding site [chemical binding]; other site
316401009509	Mg2+ binding site [ion binding]; other site
316401009510	G-X-G motif; other site
316401009511	2 probable transmembrane helices predicted for ETEC2353 by TMHMM2.0 at aa 15-37 and 192-211
316401009512	acetoacetate metabolism regulatory protein AtoC; Provisional; Region: PRK11361
316401009513	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316401009514	active site
316401009515	phosphorylation site [posttranslational modification]
316401009516	intermolecular recognition site; other site
316401009517	dimerization interface [polypeptide binding]; other site
316401009518	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316401009519	Walker A motif; other site
316401009520	ATP binding site [chemical binding]; other site
316401009521	Walker B motif; other site
316401009522	arginine finger; other site
316401009523	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
316401009524	PS00675 Sigma-54 interaction domain ATP-binding region A signature.
316401009525	PS00676 Sigma-54 interaction domain ATP-binding region B signature.
316401009526	PS00688 Sigma-54 interaction domain C-terminal part signature.
316401009527	acetyl-CoA:acetoacetyl-CoA transferase subunit alpha; Provisional; Region: PRK09920
316401009528	PS01273 CoA transferases signature 1.
316401009529	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
316401009530	PS01274 CoA transferases signature 2.
316401009531	Short chain fatty acid transporter; Region: SCFA_trans; pfam02667
316401009532	Signal peptide predicted for ETEC2357 by SignalP 2.0 HMM (Signal peptide probability 0.782) with cleavage site probability 0.600 between residues 35 and 36
316401009533	9 probable transmembrane helices predicted for ETEC2357 by TMHMM2.0 at aa 20-40, 53-75, 95-117, 138-160, 175-197, 245-262, 266-285, 298-320 and 417-439
316401009534	putative acyltransferase; Provisional; Region: PRK05790
316401009535	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
316401009536	dimer interface [polypeptide binding]; other site
316401009537	active site
316401009538	Signal peptide predicted for ETEC2358 by SignalP 2.0 HMM (Signal peptide probability 0.744) with cleavage site probability 0.625 between residues 22 and 23
316401009539	PS00098 Thiolases acyl-enzyme intermediate signature.
316401009540	PS00737 Thiolases signature 2.
316401009541	PS00099 Thiolases active site.
316401009542	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676
316401009543	Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906
316401009544	Signal peptide predicted for ETEC2359 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 19 and 20
316401009545	Predicted secreted protein [Function unknown]; Region: COG5445
316401009546	Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062
316401009547	Predicted secreted protein [Function unknown]; Region: COG5445
316401009548	Stage II sporulation protein; Region: SpoIID; pfam08486
316401009549	Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062
316401009550	Signal peptide predicted for ETEC2360 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.996 between residues 19 and 20
316401009551	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
316401009552	MG2 domain; Region: A2M_N; pfam01835
316401009553	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
316401009554	Alpha-2-macroglobulin family; Region: A2M; pfam00207
316401009555	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
316401009556	Signal peptide predicted for ETEC2361 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.995 between residues 38 and 39
316401009557	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234
316401009558	Signal peptide predicted for ETEC2362 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.968 between residues 19 and 20
316401009559	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4685
316401009560	1 probable transmembrane helix predicted for ETEC2363 by TMHMM2.0 at aa 12-34
316401009561	Signal peptide predicted for ETEC2363 by SignalP 2.0 HMM (Signal peptide probability 0.986) with cleavage site probability 0.962 between residues 30 and 31
316401009562	DNA gyrase subunit A; Validated; Region: PRK05560
316401009563	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
316401009564	CAP-like domain; other site
316401009565	active site
316401009566	primary dimer interface [polypeptide binding]; other site
316401009567	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
316401009568	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
316401009569	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
316401009570	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
316401009571	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
316401009572	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
316401009573	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
316401009574	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316401009575	S-adenosylmethionine binding site [chemical binding]; other site
316401009576	adhesin; Provisional; Region: PRK09752
316401009577	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
316401009578	Autotransporter beta-domain; Region: Autotransporter; pfam03797
316401009579	Signal peptide predicted for ETEC2366 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.852 between residues 28 and 29
316401009580	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103
316401009581	ATP cone domain; Region: ATP-cone; pfam03477
316401009582	Class I ribonucleotide reductase; Region: RNR_I; cd01679
316401009583	active site
316401009584	dimer interface [polypeptide binding]; other site
316401009585	catalytic residues [active]
316401009586	effector binding site; other site
316401009587	R2 peptide binding site; other site
316401009588	PS00089 Ribonucleotide reductase large subunit signature.
316401009589	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
316401009590	dimer interface [polypeptide binding]; other site
316401009591	putative radical transfer pathway; other site
316401009592	diiron center [ion binding]; other site
316401009593	tyrosyl radical; other site
316401009594	PS00368 Ribonucleotide reductase small subunit signature.
316401009595	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
316401009596	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
316401009597	catalytic loop [active]
316401009598	iron binding site [ion binding]; other site
316401009599	PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature.
316401009600	hypothetical protein; Provisional; Region: PRK09902
316401009601	PS00213 Lipocalin signature.
316401009602	hypothetical protein; Provisional; Region: PRK09729
316401009603	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
316401009604	Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600
316401009605	active site
316401009606	catalytic site [active]
316401009607	metal binding site [ion binding]; metal-binding site
316401009608	PS00017 ATP/GTP-binding site motif A (P-loop).
316401009609	Signal peptide predicted for ETEC2372 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 25 and 26
316401009610	sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273
316401009611	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401009612	putative substrate translocation pore; other site
316401009613	12 probable transmembrane helices predicted for ETEC2373 by TMHMM2.0 at aa 28-45, 65-87, 94-116, 120-142, 155-177, 187-206, 254-273, 293-312, 319-341, 351-373, 386-408 and 418-437
316401009614	PS00942 glpT family of transporters signature.
316401009615	sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101
316401009616	hydroxyglutarate oxidase; Provisional; Region: PRK11728
316401009617	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
316401009618	PS00977 FAD-dependent glycerol-3-phosphate dehydrogenase signature 1.
316401009619	PS00978 FAD-dependent glycerol-3-phosphate dehydrogenase signature 2.
316401009620	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075
316401009621	anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329
316401009622	glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379
316401009623	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
316401009624	Cysteine-rich domain; Region: CCG; pfam02754
316401009625	Cysteine-rich domain; Region: CCG; pfam02754
316401009626	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401009627	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401009628	hypothetical protein; Provisional; Region: PRK09956
316401009629	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
316401009631	2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128
316401009632	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
316401009633	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401009634	putative substrate translocation pore; other site
316401009635	12 probable transmembrane helices predicted for ETEC2380 by TMHMM2.0 at aa 13-30, 52-74, 79-101, 107-129, 142-164, 174-196, 241-263, 273-295, 308-325, 329-351, 358-380 and 395-417
316401009636	L-rhamnonate dehydratase; Provisional; Region: PRK15440
316401009637	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327
316401009638	putative active site pocket [active]
316401009639	putative metal binding site [ion binding]; other site
316401009640	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
316401009641	Transcriptional regulator [Transcription]; Region: IclR; COG1414
316401009642	Bacterial transcriptional regulator; Region: IclR; pfam01614
316401009643	PS01051 Bacterial regulatory proteins, iclR family signature.
316401009644	hypothetical protein; Provisional; Region: PRK03673
316401009645	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
316401009646	putative MPT binding site; other site
316401009647	Competence-damaged protein; Region: CinA; cl00666
316401009648	YfaZ precursor; Region: YfaZ; pfam07437
316401009649	outer membrane protein; Region: OMP_w_GlyGly; TIGR04219
316401009650	Signal peptide predicted for ETEC2384 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.877 between residues 21 and 22
316401009651	nucleoside triphosphatase NudI; Provisional; Region: PRK15472
316401009652	PS00893 mutT domain signature.
316401009653	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
316401009654	catalytic core [active]
316401009655	1 probable transmembrane helix predicted for ETEC2386 by TMHMM2.0 at aa 15-37
316401009656	Signal peptide predicted for ETEC2386 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.691 between residues 31 and 32
316401009657	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
316401009658	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
316401009659	inhibitor-cofactor binding pocket; inhibition site
316401009660	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316401009661	catalytic residue [active]
316401009662	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
316401009663	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
316401009664	Ligand binding site; other site
316401009665	Putative Catalytic site; other site
316401009666	DXD motif; other site
316401009667	2 probable transmembrane helices predicted for ETEC2388 by TMHMM2.0 at aa 236-258 and 273-295
316401009668	bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125
316401009669	ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644
316401009670	substrate binding site [chemical binding]; other site
316401009671	cosubstrate binding site; other site
316401009672	catalytic site [active]
316401009673	C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702
316401009674	active site
316401009675	hexamer interface [polypeptide binding]; other site
316401009676	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
316401009677	NAD binding site [chemical binding]; other site
316401009678	substrate binding site [chemical binding]; other site
316401009679	active site
316401009680	4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394
316401009681	Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939
316401009682	putative active site [active]
316401009683	putative catalytic site [active]
316401009684	putative Zn binding site [ion binding]; other site
316401009685	4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279
316401009686	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
316401009687	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401009688	12 probable transmembrane helices predicted for ETEC2391 by TMHMM2.0 at aa 7-29, 82-104, 111-133, 137-154, 167-189, 204-226, 257-279, 289-308, 315-334, 344-366, 379-401 and 406-425
316401009689	PS00017 ATP/GTP-binding site motif A (P-loop).
316401009690	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051
316401009691	Signal peptide predicted for ETEC2392 by SignalP 2.0 HMM (Signal peptide probability 0.817) with cleavage site probability 0.532 between residues 20 and 21
316401009692	3 probable transmembrane helices predicted for ETEC2392 by TMHMM2.0 at aa 36-58, 63-85 and 92-109
316401009693	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
316401009694	4 probable transmembrane helices predicted for ETEC2393 by TMHMM2.0 at aa 5-27, 37-59, 72-94 and 99-121
316401009695	signal transduction protein PmrD; Provisional; Region: PRK15450
316401009696	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029
316401009697	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
316401009698	acyl-activating enzyme (AAE) consensus motif; other site
316401009699	putative AMP binding site [chemical binding]; other site
316401009700	putative active site [active]
316401009701	putative CoA binding site [chemical binding]; other site
316401009702	PS00455 Putative AMP-binding domain signature.
316401009703	O-succinylbenzoate synthase; Provisional; Region: PRK05105
316401009704	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
316401009705	active site
316401009706	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
316401009707	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
316401009708	substrate binding site [chemical binding]; other site
316401009709	oxyanion hole (OAH) forming residues; other site
316401009710	trimer interface [polypeptide binding]; other site
316401009711	PS00166 Enoyl-CoA hydratase/isomerase signature.
316401009712	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126
316401009713	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
316401009714	nucleophilic elbow; other site
316401009715	catalytic triad; other site
316401009716	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
316401009717	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
316401009718	dimer interface [polypeptide binding]; other site
316401009719	tetramer interface [polypeptide binding]; other site
316401009720	PYR/PP interface [polypeptide binding]; other site
316401009721	TPP binding site [chemical binding]; other site
316401009722	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
316401009723	TPP-binding site; other site
316401009724	menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012
316401009725	isochorismate synthases; Region: isochor_syn; TIGR00543
316401009726	hypothetical protein; Provisional; Region: PRK10404
316401009727	1 probable transmembrane helix predicted for ETEC2401 by TMHMM2.0 at aa 80-99
316401009728	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
316401009729	Coenzyme A binding pocket [chemical binding]; other site
316401009730	ribonuclease BN; Region: true_RNase_BN; TIGR02649
316401009731	deubiquitinase; Provisional; Region: PRK11836; cl08202
316401009732	IS1 transposase; Region: DDE_Tnp_IS1; pfam03400
316401009733	von Willebrand factor; Region: vWF_A; pfam12450
316401009734	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
316401009735	VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465
316401009736	metal ion-dependent adhesion site (MIDAS); other site
316401009737	Domain of unknown function (DUF3520); Region: DUF3520; pfam12034
316401009738	Signal peptide predicted for ETEC2406 by SignalP 2.0 HMM (Signal peptide probability 0.959) with cleavage site probability 0.730 between residues 26 and 27
316401009739	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401009740	M28 Zn-Peptidases; Region: M28_like_1; cd05640
316401009741	Peptidase family M28; Region: Peptidase_M28; pfam04389
316401009742	metal binding site [ion binding]; metal-binding site
316401009743	Signal peptide predicted for ETEC2407 by SignalP 2.0 HMM (Signal peptide probability 0.822) with cleavage site probability 0.411 between residues 28 and 29
316401009744	1 probable transmembrane helix predicted for ETEC2407 by TMHMM2.0 at aa 5-27
316401009745	Domain of unknown function (DUF1877); Region: DUF1877; pfam08974
316401009746	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
316401009747	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
316401009748	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
316401009749	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
316401009750	12 probable transmembrane helices predicted for ETEC2411 by TMHMM2.0 at aa 15-37, 44-61, 65-87, 99-121, 141-163, 176-198, 208-230, 237-259, 269-291, 311-333, 348-370 and 390-412
316401009751	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
316401009752	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
316401009753	14 probable transmembrane helices predicted for ETEC2412 by TMHMM2.0 at aa 4-18, 30-49, 81-103, 115-134, 139-161, 174-196, 222-244, 251-273, 288-307, 314-336, 341-363, 384-406, 416-438 and 459-481
316401009754	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
316401009755	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
316401009756	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
316401009757	16 probable transmembrane helices predicted for ETEC2413 by TMHMM2.0 at aa 4-21, 28-50, 84-106, 113-132, 136-158, 171-193, 213-235, 248-267, 277-299, 306-328, 332-354, 375-397, 412-434, 455-477, 492-514 and 590-612
316401009758	Signal peptide predicted for ETEC2413 by SignalP 2.0 HMM (Signal peptide probability 0.947) with cleavage site probability 0.549 between residues 26 and 27
316401009759	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
316401009760	3 probable transmembrane helices predicted for ETEC2414 by TMHMM2.0 at aa 4-23, 28-50 and 60-82
316401009761	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
316401009762	5 probable transmembrane helices predicted for ETEC2415 by TMHMM2.0 at aa 4-22, 29-51, 56-78, 91-113 and 133-155
316401009763	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
316401009764	4Fe-4S binding domain; Region: Fer4; pfam00037
316401009765	4Fe-4S binding domain; Region: Fer4; pfam00037
316401009766	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401009767	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401009768	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
316401009769	8 probable transmembrane helices predicted for ETEC2417 by TMHMM2.0 at aa 10-32, 81-103, 113-135, 155-174, 184-206, 235-257, 267-289 and 302-324
316401009770	PS00668 Respiratory-chain NADH dehydrogenase subunit 1 signature 2.
316401009771	PS00667 Respiratory-chain NADH dehydrogenase subunit 1 signature 1.
316401009772	NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034
316401009773	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
316401009774	catalytic loop [active]
316401009775	iron binding site [ion binding]; other site
316401009776	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
316401009777	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
316401009778	[4Fe-4S] binding site [ion binding]; other site
316401009779	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
316401009780	PS00643 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3.
316401009781	PS00642 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2.
316401009782	PS00641 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1.
316401009783	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401009784	NADH dehydrogenase I subunit F; Provisional; Region: PRK11278
316401009785	SLBB domain; Region: SLBB; pfam10531
316401009786	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
316401009787	PS00645 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2.
316401009788	PS00644 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1.
316401009789	NADH dehydrogenase subunit E; Validated; Region: PRK07539
316401009790	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
316401009791	putative dimer interface [polypeptide binding]; other site
316401009792	[2Fe-2S] cluster binding site [ion binding]; other site
316401009793	PS01099 Respiratory-chain NADH dehydrogenase 24 Kd subunit signature.
316401009794	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
316401009795	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
316401009796	NADH dehydrogenase subunit D; Validated; Region: PRK06075
316401009797	PS00535 Respiratory chain NADH dehydrogenase 49 Kd subunit signature.
316401009798	PS00542 Respiratory chain NADH dehydrogenase 30 Kd subunit signature.
316401009799	NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377
316401009800	PS01150 Respiratory-chain NADH dehydrogenase 20 Kd subunit signature.
316401009801	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
316401009802	3 probable transmembrane helices predicted for ETEC2423 by TMHMM2.0 at aa 15-37, 68-90 and 100-122
316401009803	PS00012 Phosphopantetheine attachment site.
316401009804	DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092
316401009805	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401009806	The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439
316401009807	putative dimerization interface [polypeptide binding]; other site
316401009808	PS00639 Eukaryotic thiol (cysteine) proteases histidine active site.
316401009809	PS00044 Bacterial regulatory proteins, lysR family signature.
316401009810	aminotransferase AlaT; Validated; Region: PRK09265
316401009811	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
316401009812	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316401009813	homodimer interface [polypeptide binding]; other site
316401009814	catalytic residue [active]
316401009815	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
316401009816	Zn2+ binding site [ion binding]; other site
316401009817	Mg2+ binding site [ion binding]; other site
316401009818	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
316401009819	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
316401009820	TrkA-C domain; Region: TrkA_C; pfam02080
316401009821	TrkA-C domain; Region: TrkA_C; pfam02080
316401009822	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
316401009823	10 probable transmembrane helices predicted for ETEC2427 by TMHMM2.0 at aa 5-24, 28-50, 57-79, 94-125, 138-160, 173-195, 470-492, 502-524, 544-566 and 586-608
316401009824	PS01271 Sodium:sulfate symporter family signature.
316401009825	putative phosphatase; Provisional; Region: PRK11587
316401009826	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
316401009827	motif II; other site
316401009828	hypothetical protein; Validated; Region: PRK05445
316401009829	hypothetical protein; Provisional; Region: PRK01816
316401009830	2 probable transmembrane helices predicted for ETEC2430 by TMHMM2.0 at aa 46-65 and 69-91
316401009831	propionate/acetate kinase; Provisional; Region: PRK12379
316401009832	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
316401009833	PS01075 Acetate and butyrate kinases family signature 1.
316401009834	PS01076 Acetate and butyrate kinases family signature 2.
316401009835	phosphate acetyltransferase; Reviewed; Region: PRK05632
316401009836	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
316401009837	DRTGG domain; Region: DRTGG; pfam07085
316401009838	phosphate acetyltransferase; Region: pta; TIGR00651
316401009839	hypothetical protein; Provisional; Region: PRK11588
316401009840	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
316401009841	11 probable transmembrane helices predicted for ETEC2433 by TMHMM2.0 at aa 19-41, 106-127, 148-165, 175-197, 204-226, 230-252, 287-309, 314-336, 349-371, 398-415 and 481-503
316401009842	PS00012 Phosphopantetheine attachment site.
316401009843	NUDIX hydrolase YfcD; Provisional; Region: PRK15393
316401009844	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697
316401009845	nudix motif; other site
316401009846	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
316401009847	active site
316401009848	metal binding site [ion binding]; metal-binding site
316401009849	homotetramer interface [polypeptide binding]; other site
316401009850	PS01269 Uncharacterized protein family UPF0025 signature.
316401009851	glutathione S-transferase; Provisional; Region: PRK15113
316401009852	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
316401009853	C-terminal domain interface [polypeptide binding]; other site
316401009854	GSH binding site (G-site) [chemical binding]; other site
316401009855	dimer interface [polypeptide binding]; other site
316401009856	C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195
316401009857	N-terminal domain interface [polypeptide binding]; other site
316401009858	putative dimer interface [polypeptide binding]; other site
316401009859	putative substrate binding pocket (H-site) [chemical binding]; other site
316401009860	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
316401009861	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
316401009862	C-terminal domain interface [polypeptide binding]; other site
316401009863	GSH binding site (G-site) [chemical binding]; other site
316401009864	dimer interface [polypeptide binding]; other site
316401009865	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
316401009866	N-terminal domain interface [polypeptide binding]; other site
316401009867	putative dimer interface [polypeptide binding]; other site
316401009868	active site
316401009869	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
316401009870	homooctamer interface [polypeptide binding]; other site
316401009871	active site
316401009872	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
316401009873	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
316401009874	putative NAD(P) binding site [chemical binding]; other site
316401009875	putative active site [active]
316401009876	IS1 transposase; Region: DDE_Tnp_IS1; pfam03400
316401009877	Similar to N-terminus of Escherichia coli B. putative transposase, yhga family protein. UniProt:A2UDI6 (EMBL:AAWW01000002 (296 aa) fasta scores: E()=2e-86, 100.000% id in 220 aa, and to N-terminus of Escherichia coli. yfci UniProt:P77768 (EMBL:U00096 (296 aa) fasta scores: E()=2e-86, 100.000% id in 220 aa
316401009878	histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619
316401009879	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
316401009880	Walker A/P-loop; other site
316401009881	ATP binding site [chemical binding]; other site
316401009882	Q-loop/lid; other site
316401009883	ABC transporter signature motif; other site
316401009884	Walker B; other site
316401009885	D-loop; other site
316401009886	H-loop/switch region; other site
316401009887	PS00211 ABC transporters family signature.
316401009888	PS00017 ATP/GTP-binding site motif A (P-loop).
316401009889	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401009890	dimer interface [polypeptide binding]; other site
316401009891	conserved gate region; other site
316401009892	putative PBP binding loops; other site
316401009893	ABC-ATPase subunit interface; other site
316401009894	3 probable transmembrane helices predicted for ETEC2443 by TMHMM2.0 at aa 24-46, 59-81 and 199-221
316401009895	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
316401009896	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
316401009897	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401009898	dimer interface [polypeptide binding]; other site
316401009899	conserved gate region; other site
316401009900	putative PBP binding loops; other site
316401009901	ABC-ATPase subunit interface; other site
316401009902	5 probable transmembrane helices predicted for ETEC2444 by TMHMM2.0 at aa 15-37, 58-80, 90-108, 149-171 and 191-213
316401009903	PS00017 ATP/GTP-binding site motif A (P-loop).
316401009904	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
316401009905	histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437
316401009906	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
316401009907	substrate binding pocket [chemical binding]; other site
316401009908	membrane-bound complex binding site; other site
316401009909	hinge residues; other site
316401009910	PS01039 Bacterial extracellular solute-binding proteins, family 3 signature.
316401009911	1 probable transmembrane helix predicted for ETEC2445 by TMHMM2.0 at aa 5-24
316401009912	Signal peptide predicted for ETEC2445 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.994 between residues 22 and 23
316401009913	ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010
316401009914	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
316401009915	substrate binding pocket [chemical binding]; other site
316401009916	membrane-bound complex binding site; other site
316401009917	hinge residues; other site
316401009918	PS01039 Bacterial extracellular solute-binding proteins, family 3 signature.
316401009919	Signal peptide predicted for ETEC2446 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.979 between residues 22 and 23
316401009920	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
316401009921	Flavoprotein; Region: Flavoprotein; pfam02441
316401009922	amidophosphoribosyltransferase; Provisional; Region: PRK09246
316401009923	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
316401009924	active site
316401009925	tetramer interface [polypeptide binding]; other site
316401009926	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
316401009927	active site
316401009928	PS00103 Purine/pyrimidine phosphoribosyl transferases signature.
316401009929	PS00443 Glutamine amidotransferases class-II active site.
316401009930	colicin V production protein; Provisional; Region: PRK10845
316401009931	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
316401009932	4 probable transmembrane helices predicted for ETEC2449 by TMHMM2.0 at aa 4-26, 31-53, 63-85 and 98-120
316401009933	cell division protein DedD; Provisional; Region: PRK11633
316401009934	Sporulation related domain; Region: SPOR; pfam05036
316401009935	1 probable transmembrane helix predicted for ETEC2450 by TMHMM2.0 at aa 10-27
316401009936	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
316401009937	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
316401009938	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
316401009939	PS01012 Folylpolyglutamate synthase signature 2.
316401009940	PS01011 Folylpolyglutamate synthase signature 1.
316401009941	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
316401009942	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
316401009943	hypothetical protein; Provisional; Region: PRK10847
316401009944	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
316401009945	4 probable transmembrane helices predicted for ETEC2453 by TMHMM2.0 at aa 27-49, 71-93, 158-180 and 190-208
316401009946	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
316401009947	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
316401009948	dimerization interface 3.5A [polypeptide binding]; other site
316401009949	active site
316401009950	putative semialdehyde dehydrogenase; Provisional; Region: PRK08040
316401009951	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
316401009952	erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438
316401009953	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
316401009954	ligand binding site [chemical binding]; other site
316401009955	NAD binding site [chemical binding]; other site
316401009956	catalytic site [active]
316401009957	homodimer interface [polypeptide binding]; other site
316401009958	PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3.
316401009959	PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature.
316401009960	flagella biosynthesis regulator; Provisional; Region: flk; PRK10715
316401009961	1 probable transmembrane helix predicted for ETEC2457 by TMHMM2.0 at aa 313-330
316401009962	putative transporter; Provisional; Region: PRK12382
316401009963	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401009964	putative substrate translocation pore; other site
316401009965	12 probable transmembrane helices predicted for ETEC2458 by TMHMM2.0 at aa 20-42, 52-71, 83-105, 120-142, 149-171, 176-198, 210-232, 247-269, 276-298, 303-325, 338-360 and 370-389
316401009966	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
316401009967	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
316401009968	dimer interface [polypeptide binding]; other site
316401009969	active site
316401009970	PS00606 Beta-ketoacyl synthases active site.
316401009971	Uncharacterized conserved protein [Function unknown]; Region: COG4121
316401009972	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
316401009973	YfcL protein; Region: YfcL; pfam08891
316401009974	hypothetical protein; Provisional; Region: PRK10621
316401009975	Predicted permeases [General function prediction only]; Region: COG0730
316401009976	8 probable transmembrane helices predicted for ETEC2463 by TMHMM2.0 at aa 7-28, 32-54, 85-104, 108-127, 140-159, 163-182, 195-217 and 237-255
316401009977	Signal peptide predicted for ETEC2463 by SignalP 2.0 HMM (Signal peptide probability 0.964) with cleavage site probability 0.740 between residues 24 and 25
316401009978	Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770
316401009979	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
316401009980	Signal peptide predicted for ETEC2464 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.995 between residues 19 and 20
316401009981	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
316401009982	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
316401009983	Tetramer interface [polypeptide binding]; other site
316401009984	active site
316401009985	FMN-binding site [chemical binding]; other site
316401009986	PS00789 Chorismate synthase signature 3.
316401009987	PS00788 Chorismate synthase signature 2.
316401009988	PS00787 Chorismate synthase signature 1.
316401009989	HemK family putative methylases; Region: hemK_fam; TIGR00536
316401009990	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316401009991	S-adenosylmethionine binding site [chemical binding]; other site
316401009992	PS00092 N-6 Adenine-specific DNA methylases signature.
316401009993	hypothetical protein; Provisional; Region: PRK04946
316401009994	Smr domain; Region: Smr; pfam01713
316401009995	Protein of unknown function (DUF2544); Region: DUF2544; pfam11245
316401009996	PS00962 Ribosomal protein S2 signature 1.
316401009997	PS00435 Peroxidases proximal heme-ligand signature.
316401009998	Signal peptide predicted for ETEC2468 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.962 between residues 21 and 22
316401009999	Fimbrial protein; Region: Fimbrial; cl01416
316401010000	1 probable transmembrane helix predicted for ETEC2469 by TMHMM2.0 at aa 9-28
316401010001	Signal peptide predicted for ETEC2469 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 27 and 28
316401010002	Fimbrial protein; Region: Fimbrial; cl01416
316401010003	Signal peptide predicted for ETEC2470 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 18 and 19
316401010004	Fimbrial protein; Region: Fimbrial; cl01416
316401010005	Signal peptide predicted for ETEC2471 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 28 and 29
316401010006	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
316401010007	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
316401010008	PS00635 Gram-negative pili assembly chaperone signature.
316401010009	Signal peptide predicted for ETEC2472 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 28 and 29
316401010010	putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284
316401010011	PapC N-terminal domain; Region: PapC_N; pfam13954
316401010012	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
316401010013	PapC C-terminal domain; Region: PapC_C; pfam13953
316401010014	PS01151 Fimbrial biogenesis outer membrane usher protein signature.
316401010015	Signal peptide predicted for ETEC2473 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.983 between residues 29 and 30
316401010016	PS00133 Zinc carboxypeptidases, zinc-binding region 2 signature.
316401010017	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
316401010018	1 probable transmembrane helix predicted for ETEC2474 by TMHMM2.0 at aa 7-26
316401010019	Signal peptide predicted for ETEC2474 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.894 between residues 25 and 26
316401010020	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
316401010021	catalytic core [active]
316401010022	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
316401010023	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
316401010024	substrate binding site [chemical binding]; other site
316401010025	oxyanion hole (OAH) forming residues; other site
316401010026	trimer interface [polypeptide binding]; other site
316401010027	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
316401010028	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
316401010029	PS00067 3-hydroxyacyl-CoA dehydrogenase signature.
316401010030	3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963
316401010031	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
316401010032	dimer interface [polypeptide binding]; other site
316401010033	active site
316401010034	PS00099 Thiolases active site.
316401010035	PS00737 Thiolases signature 2.
316401010036	PS00098 Thiolases acyl-enzyme intermediate signature.
316401010037	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691
316401010038	long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716
316401010039	Signal peptide predicted for ETEC2479 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 27 and 28
316401010040	ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091
316401010041	Signal peptide predicted for ETEC2481 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.367 between residues 21 and 22
316401010042	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401010043	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
316401010044	6 probable transmembrane helices predicted for ETEC2482 by TMHMM2.0 at aa 59-81, 91-113, 134-156, 187-206, 213-232 and 252-274
316401010045	DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086
316401010046	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401010047	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
316401010048	dimerization interface [polypeptide binding]; other site
316401010049	substrate binding pocket [chemical binding]; other site
316401010050	PS00044 Bacterial regulatory proteins, lysR family signature.
316401010051	permease DsdX; Provisional; Region: PRK09921
316401010052	gluconate transporter; Region: gntP; TIGR00791
316401010053	12 probable transmembrane helices predicted for ETEC2484 by TMHMM2.0 at aa 5-23, 27-49, 54-76, 104-126, 139-161, 176-198, 225-244, 259-281, 300-322, 342-364, 385-407 and 422-444
316401010054	D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine  to pyruvate and ammonia.  D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447
316401010055	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
316401010056	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
316401010057	catalytic residue [active]
316401010058	PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site.
316401010059	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
316401010060	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401010061	putative substrate translocation pore; other site
316401010062	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401010063	13 probable transmembrane helices predicted for ETEC2486 by TMHMM2.0 at aa 7-29, 55-77, 84-106, 110-132, 144-166, 171-193, 206-223, 233-255, 276-295, 305-327, 339-358, 373-395 and 484-502
316401010064	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
316401010065	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
316401010066	HlyD family secretion protein; Region: HlyD_3; pfam13437
316401010067	1 probable transmembrane helix predicted for ETEC2487 by TMHMM2.0 at aa 16-35
316401010068	Signal peptide predicted for ETEC2487 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.990 between residues 33 and 34
316401010069	DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958
316401010070	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316401010071	active site
316401010072	phosphorylation site [posttranslational modification]
316401010073	intermolecular recognition site; other site
316401010074	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
316401010075	DNA binding residues [nucleotide binding]
316401010076	dimerization interface [polypeptide binding]; other site
316401010077	PS00622 Bacterial regulatory proteins, luxR family signature.
316401010078	hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959
316401010079	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
316401010080	substrate binding pocket [chemical binding]; other site
316401010081	membrane-bound complex binding site; other site
316401010082	hinge residues; other site
316401010083	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
316401010084	substrate binding pocket [chemical binding]; other site
316401010085	membrane-bound complex binding site; other site
316401010086	hinge residues; other site
316401010087	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316401010088	dimer interface [polypeptide binding]; other site
316401010089	phosphorylation site [posttranslational modification]
316401010090	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316401010091	ATP binding site [chemical binding]; other site
316401010092	Mg2+ binding site [ion binding]; other site
316401010093	G-X-G motif; other site
316401010094	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316401010095	active site
316401010096	phosphorylation site [posttranslational modification]
316401010097	intermolecular recognition site; other site
316401010098	dimerization interface [polypeptide binding]; other site
316401010099	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
316401010100	putative binding surface; other site
316401010101	active site
316401010102	Signal peptide predicted for ETEC2489 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 21 and 22
316401010103	PS00881 Protein splicing signature.
316401010104	putative CoA-transferase; Provisional; Region: PRK11430
316401010105	CoA-transferase family III; Region: CoA_transf_3; pfam02515
316401010106	PS00017 ATP/GTP-binding site motif A (P-loop).
316401010107	putative transporter YfdV; Provisional; Region: PRK09903
316401010108	10 probable transmembrane helices predicted for ETEC2491 by TMHMM2.0 at aa 4-23, 36-53, 68-90, 97-116, 131-153, 174-196, 200-222, 229-251, 261-283 and 290-309
316401010109	putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259
316401010110	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
316401010111	PYR/PP interface [polypeptide binding]; other site
316401010112	dimer interface [polypeptide binding]; other site
316401010113	TPP binding site [chemical binding]; other site
316401010114	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
316401010115	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
316401010116	TPP-binding site; other site
316401010117	dimer interface [polypeptide binding]; other site
316401010118	PS00177 DNA topoisomerase II signature.
316401010119	formyl-coenzyme A transferase; Provisional; Region: PRK05398
316401010120	CoA-transferase family III; Region: CoA_transf_3; pfam02515
316401010121	hypothetical protein; Provisional; Region: PRK10316
316401010122	YfdX protein; Region: YfdX; pfam10938
316401010123	Signal peptide predicted for ETEC2494 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 21 and 22
316401010124	Signal peptide predicted for ETEC2495 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.982 between residues 23 and 24
316401010125	1 probable transmembrane helix predicted for ETEC2495 by TMHMM2.0 at aa 5-27
316401010126	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401010127	Protein of unknown function (DUF2545); Region: DUF2545; pfam10810
316401010128	3 probable transmembrane helices predicted for ETEC2496 by TMHMM2.0 at aa 4-26, 28-50 and 55-77
316401010129	Signal peptide predicted for ETEC2496 by SignalP 2.0 HMM (Signal peptide probability 0.846) with cleavage site probability 0.366 between residues 24 and 25
316401010130	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
316401010131	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
316401010132	putative acyl-acceptor binding pocket; other site
316401010133	1 probable transmembrane helix predicted for ETEC2497 by TMHMM2.0 at aa 20-42
316401010134	PS00030 Eukaryotic putative RNA-binding region RNP-1 signature.
316401010135	aminotransferase; Validated; Region: PRK08175
316401010136	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
316401010137	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316401010138	homodimer interface [polypeptide binding]; other site
316401010139	catalytic residue [active]
316401010140	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
316401010141	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
316401010142	GAF domain; Region: GAF; pfam01590
316401010143	Histidine kinase; Region: His_kinase; pfam06580
316401010144	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316401010145	ATP binding site [chemical binding]; other site
316401010146	Mg2+ binding site [ion binding]; other site
316401010147	G-X-G motif; other site
316401010148	6 probable transmembrane helices predicted for ETEC2499 by TMHMM2.0 at aa 4-26, 45-62, 77-99, 106-128, 138-160 and 169-191
316401010149	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
316401010150	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316401010151	active site
316401010152	phosphorylation site [posttranslational modification]
316401010153	intermolecular recognition site; other site
316401010154	dimerization interface [polypeptide binding]; other site
316401010155	LytTr DNA-binding domain; Region: LytTR; pfam04397
316401010156	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
316401010157	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316401010158	PS00041 Bacterial regulatory proteins, araC family signature.
316401010159	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
316401010160	dimerization domain swap beta strand [polypeptide binding]; other site
316401010161	regulatory protein interface [polypeptide binding]; other site
316401010162	active site
316401010163	regulatory phosphorylation site [posttranslational modification]; other site
316401010164	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
316401010165	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
316401010166	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
316401010167	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
316401010168	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
316401010169	active site
316401010170	phosphorylation site [posttranslational modification]
316401010171	PS00215 Mitochondrial energy transfer proteins signature.
316401010172	exoaminopeptidase; Provisional; Region: PRK09961
316401010173	M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638
316401010174	oligomer interface [polypeptide binding]; other site
316401010175	active site
316401010176	metal binding site [ion binding]; metal-binding site
316401010177	aminopeptidase; Provisional; Region: PRK09795
316401010178	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
316401010179	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
316401010180	active site
316401010181	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
316401010182	10 probable transmembrane helices predicted for ETEC2505 by TMHMM2.0 at aa 46-68, 97-119, 126-145, 160-178, 198-220, 240-262, 275-297, 317-335, 342-364 and 379-401
316401010183	Signal peptide predicted for ETEC2505 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.493 between residues 20 and 21
316401010184	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
316401010185	active site
316401010186	P-loop; other site
316401010187	phosphorylation site [posttranslational modification]
316401010188	Signal peptide predicted for ETEC2506 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.665 between residues 24 and 25
316401010189	glucokinase, proteobacterial type; Region: glk; TIGR00749
316401010190	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
316401010191	nucleotide binding site [chemical binding]; other site
316401010192	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
316401010193	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
316401010194	Cl- selectivity filter; other site
316401010195	Cl- binding residues [ion binding]; other site
316401010196	pore gating glutamate residue; other site
316401010197	dimer interface [polypeptide binding]; other site
316401010198	Signal peptide predicted for ETEC2508 by SignalP 2.0 HMM (Signal peptide probability 0.892) with cleavage site probability 0.529 between residues 24 and 25
316401010199	11 probable transmembrane helices predicted for ETEC2508 by TMHMM2.0 at aa 9-31, 55-77, 90-112, 122-140, 147-169, 189-211, 223-244, 259-281, 301-323, 343-363 and 376-398
316401010200	Protein of unknown function (DUF2502); Region: DUF2502; pfam10697
316401010201	Signal peptide predicted for ETEC2509 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.991 between residues 21 and 22
316401010202	manganese transport protein MntH; Reviewed; Region: PRK00701
316401010203	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
316401010204	11 probable transmembrane helices predicted for ETEC2510 by TMHMM2.0 at aa 20-39, 54-76, 96-118, 123-145, 157-176, 196-218, 239-261, 290-312, 324-343, 348-370 and 391-410
316401010205	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
316401010206	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
316401010207	Nucleoside recognition; Region: Gate; pfam07670
316401010208	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
316401010209	8 probable transmembrane helices predicted for ETEC2511 by TMHMM2.0 at aa 4-23, 30-48, 86-108, 193-212, 249-271, 278-300, 342-364 and 377-399
316401010210	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
316401010211	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
316401010212	MASE1; Region: MASE1; pfam05231
316401010213	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
316401010214	diguanylate cyclase; Region: GGDEF; smart00267
316401010215	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
316401010216	8 probable transmembrane helices predicted for ETEC2513 by TMHMM2.0 at aa 15-37, 42-64, 82-104, 125-147, 162-184, 215-234, 238-255 and 289-311
316401010217	Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037
316401010218	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
316401010219	salt bridge; other site
316401010220	non-specific DNA binding site [nucleotide binding]; other site
316401010221	sequence-specific DNA binding site [nucleotide binding]; other site
316401010222	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
316401010223	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
316401010224	active site
316401010225	HIGH motif; other site
316401010226	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
316401010227	active site
316401010228	KMSKS motif; other site
316401010229	PS00178 Aminoacyl-transfer RNA synthetases class-I signature.
316401010230	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
316401010231	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401010232	The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449
316401010233	putative dimerization interface [polypeptide binding]; other site
316401010234	putative substrate binding pocket [chemical binding]; other site
316401010235	PS00044 Bacterial regulatory proteins, lysR family signature.
316401010236	nucleoside transporter; Region: 2A0110; TIGR00889
316401010237	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401010238	putative substrate translocation pore; other site
316401010239	12 probable transmembrane helices predicted for ETEC2518 by TMHMM2.0 at aa 12-30, 40-62, 71-90, 94-116, 128-150, 160-179, 212-234, 249-271, 278-300, 305-327, 347-369 and 380-402
316401010240	purine nucleoside phosphorylase; Provisional; Region: PRK08202
316401010241	PS01240 Purine and other phosphorylases family 2 signature.
316401010242	hypothetical protein; Provisional; Region: PRK11528
316401010243	Signal peptide predicted for ETEC2520 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.979 between residues 22 and 23
316401010244	Transcriptional regulator [Transcription]; Region: LysR; COG0583
316401010245	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401010246	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
316401010247	putative dimerization interface [polypeptide binding]; other site
316401010248	PS00044 Bacterial regulatory proteins, lysR family signature.
316401010249	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
316401010250	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
316401010251	Signal peptide predicted for ETEC2522 by SignalP 2.0 HMM (Signal peptide probability 0.980) with cleavage site probability 0.979 between residues 28 and 29
316401010252	8 probable transmembrane helices predicted for ETEC2522 by TMHMM2.0 at aa 7-26, 30-47, 67-89, 99-118, 130-152, 167-186, 229-251 and 288-310
316401010253	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530
316401010254	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
316401010255	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
316401010256	nucleotide binding pocket [chemical binding]; other site
316401010257	K-X-D-G motif; other site
316401010258	catalytic site [active]
316401010259	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
316401010260	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
316401010261	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
316401010262	Dimer interface [polypeptide binding]; other site
316401010263	BRCT sequence motif; other site
316401010264	PS01056 NAD-dependent DNA ligase signature 2.
316401010265	PS01055 NAD-dependent DNA ligase signature 1.
316401010266	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038
316401010267	cell division protein ZipA; Provisional; Region: PRK03427
316401010268	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231
316401010269	FtsZ protein binding site [polypeptide binding]; other site
316401010270	1 probable transmembrane helix predicted for ETEC2525 by TMHMM2.0 at aa 5-27
316401010271	Signal peptide predicted for ETEC2525 by SignalP 2.0 HMM (Signal peptide probability 0.896) with cleavage site probability 0.892 between residues 24 and 25
316401010272	putative sulfate transport protein CysZ; Validated; Region: PRK04949
316401010273	4 probable transmembrane helices predicted for ETEC2526 by TMHMM2.0 at aa 31-53, 68-90, 151-173 and 220-242
316401010274	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
316401010275	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
316401010276	dimer interface [polypeptide binding]; other site
316401010277	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316401010278	catalytic residue [active]
316401010279	PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site.
316401010280	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
316401010281	dimerization domain swap beta strand [polypeptide binding]; other site
316401010282	regulatory protein interface [polypeptide binding]; other site
316401010283	active site
316401010284	regulatory phosphorylation site [posttranslational modification]; other site
316401010285	PS00369 PTS HPR component histidine phosphorylation site signature.
316401010286	PS00589 PTS HPR component serine phosphorylation site signature.
316401010287	phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177
316401010288	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
316401010289	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
316401010290	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
316401010291	PS00370 PEP-utilizing enzymes phosphorylation site signature.
316401010292	PS00742 PEP-utilizing enzymes signature 2.
316401010293	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
316401010294	HPr interaction site; other site
316401010295	glycerol kinase (GK) interaction site [polypeptide binding]; other site
316401010296	active site
316401010297	phosphorylation site [posttranslational modification]
316401010298	PS00371 PTS EIIA domains phosphorylation site signature 1.
316401010299	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
316401010300	dimer interface [polypeptide binding]; other site
316401010301	pyridoxamine kinase; Validated; Region: PRK05756
316401010302	pyridoxal binding site [chemical binding]; other site
316401010303	ATP binding site [chemical binding]; other site
316401010304	hypothetical protein; Provisional; Region: PRK10318
316401010305	Signal peptide predicted for ETEC2532 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 19 and 20
316401010306	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
316401010307	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884
316401010308	cysteine synthase B; Region: cysM; TIGR01138
316401010309	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
316401010310	dimer interface [polypeptide binding]; other site
316401010311	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316401010312	catalytic residue [active]
316401010313	PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site.
316401010314	sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851
316401010315	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
316401010316	Walker A/P-loop; other site
316401010317	ATP binding site [chemical binding]; other site
316401010318	Q-loop/lid; other site
316401010319	ABC transporter signature motif; other site
316401010320	Walker B; other site
316401010321	D-loop; other site
316401010322	H-loop/switch region; other site
316401010323	TOBE-like domain; Region: TOBE_3; pfam12857
316401010324	PS00211 ABC transporters family signature.
316401010325	PS00017 ATP/GTP-binding site motif A (P-loop).
316401010326	sulfate transport protein; Provisional; Region: cysT; CHL00187
316401010327	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401010328	dimer interface [polypeptide binding]; other site
316401010329	conserved gate region; other site
316401010330	putative PBP binding loops; other site
316401010331	ABC-ATPase subunit interface; other site
316401010332	6 probable transmembrane helices predicted for ETEC2536 by TMHMM2.0 at aa 20-42, 69-91, 103-125, 140-162, 201-223 and 246-268
316401010333	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
316401010334	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
316401010335	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401010336	dimer interface [polypeptide binding]; other site
316401010337	conserved gate region; other site
316401010338	putative PBP binding loops; other site
316401010339	ABC-ATPase subunit interface; other site
316401010340	7 probable transmembrane helices predicted for ETEC2537 by TMHMM2.0 at aa 15-37, 62-84, 104-126, 138-160, 188-205, 212-234 and 244-266
316401010341	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
316401010342	Signal peptide predicted for ETEC2537 by SignalP 2.0 HMM (Signal peptide probability 0.988) with cleavage site probability 0.606 between residues 36 and 37
316401010343	thiosulfate transporter subunit; Provisional; Region: PRK10852
316401010344	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
316401010345	PS00757 Prokaryotic sulfate-binding proteins signature 2.
316401010346	PS00401 Prokaryotic sulfate-binding proteins signature 1.
316401010347	PS00092 N-6 Adenine-specific DNA methylases signature.
316401010348	Signal peptide predicted for ETEC2538 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 25 and 26
316401010349	short chain dehydrogenase; Provisional; Region: PRK08226
316401010350	human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368
316401010351	NAD binding site [chemical binding]; other site
316401010352	homotetramer interface [polypeptide binding]; other site
316401010353	homodimer interface [polypeptide binding]; other site
316401010354	active site
316401010355	transcriptional regulator MurR; Provisional; Region: PRK15482
316401010356	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
316401010357	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
316401010358	putative active site [active]
316401010359	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
316401010360	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
316401010361	putative active site [active]
316401010362	PS01272 Glucokinase regulatory protein family signature.
316401010363	PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586
316401010364	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
316401010365	active site turn [active]
316401010366	phosphorylation site [posttranslational modification]
316401010367	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
316401010368	PS01035 PTS EIIB domains cysteine phosphorylation site signature.
316401010369	10 probable transmembrane helices predicted for ETEC2542 by TMHMM2.0 at aa 121-143, 158-177, 184-203, 218-240, 261-283, 298-320, 332-354, 369-388, 395-417 and 444-466
316401010370	PS00024 Hemopexin domain signature.
316401010371	putative periplasmic esterase; Provisional; Region: PRK03642
316401010372	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
316401010373	Signal peptide predicted for ETEC2543 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.913 between residues 19 and 20
316401010374	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401010375	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
316401010376	RpoE-regulated lipoprotein; Provisional; Region: PRK10718
316401010377	Protein of unknown function (DUF1131); Region: DUF1131; pfam06572
316401010378	Signal peptide predicted for ETEC2545 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.681 between residues 27 and 28
316401010379	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401010380	Protein of unknown function (DUF2919); Region: DUF2919; pfam11143
316401010381	4 probable transmembrane helices predicted for ETEC2546 by TMHMM2.0 at aa 21-43, 58-77, 90-109 and 113-135
316401010382	putative acetyltransferase; Provisional; Region: PRK03624
316401010383	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
316401010384	Coenzyme A binding pocket [chemical binding]; other site
316401010385	N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319
316401010386	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
316401010387	active site
316401010388	metal binding site [ion binding]; metal-binding site
316401010389	Signal peptide predicted for ETEC2548 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.975 between residues 34 and 35
316401010390	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
316401010391	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
316401010392	PS01021 Coproporphyrinogen III oxidase signature.
316401010393	transcriptional regulator EutR; Provisional; Region: PRK10130
316401010394	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316401010395	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316401010396	PS00041 Bacterial regulatory proteins, araC family signature.
316401010397	carboxysome structural protein EutK; Provisional; Region: PRK15466
316401010398	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
316401010399	Hexamer interface [polypeptide binding]; other site
316401010400	Hexagonal pore residue; other site
316401010401	PS01139 Bacterial microcompartiments proteins signature.
316401010402	ethanolamine utilization protein EutL; Provisional; Region: PRK15405
316401010403	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049
316401010404	putative hexamer interface [polypeptide binding]; other site
316401010405	putative hexagonal pore; other site
316401010406	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050
316401010407	putative hexamer interface [polypeptide binding]; other site
316401010408	putative hexagonal pore; other site
316401010409	Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302
316401010410	Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303
316401010411	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
316401010412	reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719
316401010413	Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192
316401010414	10 probable transmembrane helices predicted for ETEC2556 by TMHMM2.0 at aa 7-29, 58-80, 87-109, 124-146, 153-175, 190-212, 231-253, 273-295, 342-364 and 369-391
316401010415	ethanol dehydrogenase EutG; Provisional; Region: PRK15454
316401010416	iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551
316401010417	active site
316401010418	metal binding site [ion binding]; metal-binding site
316401010419	PS00060 Iron-containing alcohol dehydrogenases signature 2.
316401010420	PS00017 ATP/GTP-binding site motif A (P-loop).
316401010421	PS00913 Iron-containing alcohol dehydrogenases signature 1.
316401010422	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401010423	Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820
316401010424	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
316401010425	nucleotide binding site [chemical binding]; other site
316401010426	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
316401010427	putative catalytic cysteine [active]
316401010428	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
316401010429	Hexamer/Pentamer interface [polypeptide binding]; other site
316401010430	central pore; other site
316401010431	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
316401010432	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
316401010433	Hexamer interface [polypeptide binding]; other site
316401010434	Putative hexagonal pore residue; other site
316401010435	PS01139 Bacterial microcompartiments proteins signature.
316401010436	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
316401010437	ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020
316401010438	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
316401010439	Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766
316401010440	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
316401010441	G1 box; other site
316401010442	GTP/Mg2+ binding site [chemical binding]; other site
316401010443	G2 box; other site
316401010444	Switch I region; other site
316401010445	G3 box; other site
316401010446	Switch II region; other site
316401010447	G4 box; other site
316401010448	G5 box; other site
316401010449	PS00017 ATP/GTP-binding site motif A (P-loop).
316401010450	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
316401010451	putative hexamer interface [polypeptide binding]; other site
316401010452	putative hexagonal pore; other site
316401010453	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
316401010454	Malic enzyme, N-terminal domain; Region: malic; pfam00390
316401010455	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
316401010456	putative NAD(P) binding site [chemical binding]; other site
316401010457	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
316401010458	transaldolase-like protein; Provisional; Region: PTZ00411
316401010459	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
316401010460	active site
316401010461	dimer interface [polypeptide binding]; other site
316401010462	catalytic residue [active]
316401010463	PS01054 Transaldolase signature 1.
316401010464	PS00958 Transaldolase active site.
316401010465	transketolase; Reviewed; Region: PRK12753
316401010466	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
316401010467	TPP-binding site [chemical binding]; other site
316401010468	dimer interface [polypeptide binding]; other site
316401010469	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
316401010470	PYR/PP interface [polypeptide binding]; other site
316401010471	dimer interface [polypeptide binding]; other site
316401010472	TPP binding site [chemical binding]; other site
316401010473	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
316401010474	PS00801 Transketolase signature 1.
316401010475	PS00802 Transketolase signature 2.
316401010476	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
316401010477	1 probable transmembrane helix predicted for ETEC2570 by TMHMM2.0 at aa 5-24
316401010478	Signal peptide predicted for ETEC2570 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 21 and 22
316401010479	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
316401010480	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
316401010481	dimer interface [polypeptide binding]; other site
316401010482	ADP-ribose binding site [chemical binding]; other site
316401010483	active site
316401010484	nudix motif; other site
316401010485	metal binding site [ion binding]; metal-binding site
316401010486	PS00017 ATP/GTP-binding site motif A (P-loop).
316401010487	putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769
316401010488	4Fe-4S binding domain; Region: Fer4; pfam00037
316401010489	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
316401010490	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
316401010491	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401010492	PS00028 Zinc finger, C2H2 type, domain.
316401010493	PS00190 Cytochrome c family heme-binding site signature.
316401010494	nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935
316401010495	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
316401010496	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
316401010497	dimerization interface [polypeptide binding]; other site
316401010498	Histidine kinase; Region: HisKA_3; pfam07730
316401010499	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316401010500	ATP binding site [chemical binding]; other site
316401010501	Mg2+ binding site [ion binding]; other site
316401010502	G-X-G motif; other site
316401010503	Signal peptide predicted for ETEC2573 by SignalP 2.0 HMM (Signal peptide probability 0.911) with cleavage site probability 0.472 between residues 40 and 41
316401010504	2 probable transmembrane helices predicted for ETEC2573 by TMHMM2.0 at aa 15-37 and 147-169
316401010505	aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555
316401010506	Protein export membrane protein; Region: SecD_SecF; cl14618
316401010507	Signal peptide predicted for ETEC2574 by SignalP 2.0 HMM (Signal peptide probability 0.771) with cleavage site probability 0.547 between residues 34 and 35
316401010508	11 probable transmembrane helices predicted for ETEC2574 by TMHMM2.0 at aa 10-32, 340-362, 366-388, 438-460, 470-492, 538-560, 868-890, 897-919, 924-946, 972-994 and 1004-1026
316401010509	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
316401010510	ArsC family; Region: ArsC; pfam03960
316401010511	putative catalytic residues [active]
316401010512	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
316401010513	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
316401010514	metal binding site [ion binding]; metal-binding site
316401010515	dimer interface [polypeptide binding]; other site
316401010516	PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1.
316401010517	PS00759 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2.
316401010518	hypothetical protein; Provisional; Region: PRK13664
316401010519	1 probable transmembrane helix predicted for ETEC2577 by TMHMM2.0 at aa 5-24
316401010520	putative hydrolase; Provisional; Region: PRK11460
316401010521	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
316401010522	Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444
316401010523	Helicase; Region: Helicase_RecD; pfam05127
316401010524	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
316401010525	Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725
316401010526	PS00017 ATP/GTP-binding site motif A (P-loop).
316401010527	Predicted metalloprotease [General function prediction only]; Region: COG2321
316401010528	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
316401010529	PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.
316401010530	1 probable transmembrane helix predicted for ETEC2580 by TMHMM2.0 at aa 38-60
316401010531	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
316401010532	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
316401010533	ATP binding site [chemical binding]; other site
316401010534	active site
316401010535	substrate binding site [chemical binding]; other site
316401010536	PS01058 SAICAR synthetase signature 2.
316401010537	PS01057 SAICAR synthetase signature 1.
316401010538	lipoprotein; Provisional; Region: PRK11679
316401010539	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
316401010540	PS00572 Glycosyl hydrolases family 1 active site.
316401010541	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401010542	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
316401010543	dihydrodipicolinate synthase; Region: dapA; TIGR00674
316401010544	dimer interface [polypeptide binding]; other site
316401010545	active site
316401010546	catalytic residue [active]
316401010547	PS00666 Dihydrodipicolinate synthetase signature 2.
316401010548	PS00665 Dihydrodipicolinate synthetase signature 1.
316401010549	glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589
316401010550	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893
316401010551	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
316401010552	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
316401010553	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
316401010554	catalytic triad [active]
316401010555	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
316401010556	4Fe-4S binding domain; Region: Fer4; pfam00037
316401010557	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401010559	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
316401010560	NADH dehydrogenase; Region: NADHdh; cl00469
316401010561	7 probable transmembrane helices predicted for ETEC2588 by TMHMM2.0 at aa 9-31, 74-96, 105-124, 139-161, 173-195, 255-277 and 290-312
316401010562	PS00668 Respiratory-chain NADH dehydrogenase subunit 1 signature 2.
316401010563	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
316401010564	Signal peptide predicted for ETEC2589 by SignalP 2.0 HMM (Signal peptide probability 0.990) with cleavage site probability 0.975 between residues 27 and 28
316401010565	10 probable transmembrane helices predicted for ETEC2589 by TMHMM2.0 at aa 4-23, 30-52, 72-94, 115-137, 197-219, 226-248, 258-280, 292-314, 337-359 and 386-405
316401010566	hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492
316401010567	7 probable transmembrane helices predicted for ETEC2590 by TMHMM2.0 at aa 5-24, 31-53, 57-79, 91-113, 128-145, 152-171 and 176-195
316401010568	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401010570	Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262
316401010571	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
316401010572	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
316401010573	PS00535 Respiratory chain NADH dehydrogenase 49 Kd subunit signature.
316401010574	hydrogenase 4 subunit H; Validated; Region: PRK08222
316401010575	4Fe-4S binding domain; Region: Fer4; pfam00037
316401010576	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401010577	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401010578	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
316401010579	PS01150 Respiratory-chain NADH dehydrogenase 20 Kd subunit signature.
316401010580	formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084
316401010581	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604
316401010582	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
316401010583	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316401010584	Walker A motif; other site
316401010585	ATP binding site [chemical binding]; other site
316401010586	Walker B motif; other site
316401010587	arginine finger; other site
316401010588	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
316401010589	PS00134 Serine proteases, trypsin family, histidine active site.
316401010590	PS00675 Sigma-54 interaction domain ATP-binding region A signature.
316401010591	PS00676 Sigma-54 interaction domain ATP-binding region B signature.
316401010592	PS00688 Sigma-54 interaction domain C-terminal part signature.
316401010593	Formate/nitrite transporter; Region: Form_Nir_trans; cl00927
316401010594	Signal peptide predicted for ETEC2597 by SignalP 2.0 HMM (Signal peptide probability 0.834) with cleavage site probability 0.820 between residues 57 and 58
316401010595	5 probable transmembrane helices predicted for ETEC2597 by TMHMM2.0 at aa 31-53, 68-90, 111-133, 165-187 and 200-222
316401010596	PS01005 Formate and nitrite transporters signature 1.
316401010597	PS01006 Formate and nitrite transporters signature 2.
316401010598	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
316401010599	Domain of unknown function DUF20; Region: UPF0118; pfam01594
316401010600	7 probable transmembrane helices predicted for ETEC2598 by TMHMM2.0 at aa 20-51, 72-94, 155-177, 217-236, 251-273, 278-300 and 310-332
316401010601	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
316401010602	Peptidase family M48; Region: Peptidase_M48; cl12018
316401010603	Signal peptide predicted for ETEC2599 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 27 and 28
316401010604	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
316401010605	ArsC family; Region: ArsC; pfam03960
316401010606	catalytic residues [active]
316401010607	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
316401010608	DNA replication initiation factor; Provisional; Region: PRK08084
316401010609	uracil transporter; Provisional; Region: PRK10720
316401010610	12 probable transmembrane helices predicted for ETEC2602 by TMHMM2.0 at aa 13-35, 39-61, 68-85, 89-108, 121-143, 158-180, 185-207, 227-249, 304-326, 331-353, 365-387 and 392-411
316401010611	PS01116 Xanthine/uracil permeases family signature.
316401010612	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
316401010613	active site
316401010614	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
316401010615	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
316401010616	dimerization interface [polypeptide binding]; other site
316401010617	putative ATP binding site [chemical binding]; other site
316401010618	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
316401010619	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
316401010620	active site
316401010621	substrate binding site [chemical binding]; other site
316401010622	cosubstrate binding site; other site
316401010623	catalytic site [active]
316401010624	PS00373 Phosphoribosylglycinamide formyltransferase active site.
316401010625	Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855
316401010626	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
316401010627	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
316401010628	Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114
316401010629	domain interface [polypeptide binding]; other site
316401010630	active site
316401010631	catalytic site [active]
316401010632	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
316401010633	putative active site [active]
316401010634	catalytic site [active]
316401010635	exopolyphosphatase; Provisional; Region: PRK10854
316401010636	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
316401010637	MASE1; Region: MASE1; pfam05231
316401010638	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
316401010639	diguanylate cyclase; Region: GGDEF; smart00267
316401010640	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
316401010641	9 probable transmembrane helices predicted for ETEC2608 by TMHMM2.0 at aa 15-36, 43-65, 80-102, 129-151, 166-188, 216-235, 240-259, 266-285 and 295-317
316401010642	Signal peptide predicted for ETEC2608 by SignalP 2.0 HMM (Signal peptide probability 0.897) with cleavage site probability 0.657 between residues 30 and 31
316401010643	Protein of unknown function (DUF2633); Region: DUF2633; pfam11119
316401010644	Signal peptide predicted for ETEC2609 by SignalP 2.0 HMM (Signal peptide probability 0.959) with cleavage site probability 0.349 between residues 36 and 37
316401010645	1 probable transmembrane helix predicted for ETEC2609 by TMHMM2.0 at aa 20-42
316401010646	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
316401010647	Signal peptide predicted for ETEC2610 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.779 between residues 26 and 27
316401010648	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401010649	Signal peptide predicted for ETEC2611 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.864 between residues 19 and 20
316401010650	Protein of unknown function (DUF2514); Region: DUF2514; pfam10721
316401010651	Signal peptide predicted for ETEC2612 by SignalP 2.0 HMM (Signal peptide probability 0.922) with cleavage site probability 0.530 between residues 22 and 23
316401010652	Predicted chitinase [General function prediction only]; Region: COG3179
316401010653	catalytic residue [active]
316401010654	Protein of unknown function (DUF754); Region: DUF754; pfam05449
316401010655	2 probable transmembrane helices predicted for ETEC2613A by TMHMM2.0 at aa 4-26 and 39-61
316401010656	3 probable transmembrane helices predicted for ETEC2613B by TMHMM2.0 at aa 10-32, 52-74 and 84-106
316401010657	Signal peptide predicted for ETEC2613B by SignalP 2.0 HMM (Signal peptide probability 0.936) with cleavage site probability 0.596 between residues 24 and 25
316401010658	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
316401010659	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
316401010660	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
316401010661	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
316401010662	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
316401010663	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
316401010664	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
316401010665	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
316401010666	Transposase; Region: HTH_Tnp_1; pfam01527
316401010667	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
316401010668	hypothetical protein; Provisional; Region: PHA02515
316401010669	1 probable transmembrane helix predicted for ETEC2619 by TMHMM2.0 at aa 4-18
316401010670	BRO family, N-terminal domain; Region: Bro-N; smart01040
316401010671	Signal peptide predicted for ETEC2622 by SignalP 2.0 HMM (Signal peptide probability 0.891) with cleavage site probability 0.834 between residues 46 and 47
316401010672	1 probable transmembrane helix predicted for ETEC2622 by TMHMM2.0 at aa 28-47
316401010673	2 probable transmembrane helices predicted for ETEC2623 by TMHMM2.0 at aa 4-23 and 30-48
316401010674	structural protein; Region: PHA01972
316401010675	PS00017 ATP/GTP-binding site motif A (P-loop).
316401010676	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
316401010677	virion protein; Provisional; Region: V; PHA02564
316401010678	Signal peptide predicted for ETEC2627 by SignalP 2.0 HMM (Signal peptide probability 0.948) with cleavage site probability 0.531 between residues 24 and 25
316401010679	hypothetical protein; Region: PHA01733
316401010680	hypothetical protein; Region: PHA00661
316401010681	hypothetical protein; Region: PHA00662
316401010682	hypothetical protein; Region: PHA00669
316401010683	hypothetical protein; Region: PHA00664
316401010684	major capsid protein; Region: PHA00665
316401010685	putative protease; Region: PHA00666
316401010686	hypothetical protein; Region: PHA00670
316401010687	Bacteriophage head to tail connecting protein; Region: Head-tail_con; pfam12236
316401010688	Terminase small subunit; Region: Terminase_2; pfam03592
316401010689	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
316401010690	active site
316401010691	Protein of unknown function (DUF1064); Region: DUF1064; pfam06356
316401010692	Replication protein P; Region: Phage_lambda_P; pfam06992
316401010693	Pyocin large subunit [General function prediction only]; Region: COG5529
316401010694	Helix-turn-helix domain; Region: HTH_36; pfam13730
316401010695	primosomal protein DnaI; Provisional; Region: PRK02854
316401010696	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
316401010697	sequence-specific DNA binding site [nucleotide binding]; other site
316401010698	salt bridge; other site
316401010699	PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684
316401010700	RecT family; Region: RecT; pfam03837
316401010701	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
316401010702	MT-A70; Region: MT-A70; cl01947
316401010703	PS00092 N-6 Adenine-specific DNA methylases signature.
316401010704	PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424
316401010705	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
316401010706	active site
316401010707	metal binding site [ion binding]; metal-binding site
316401010708	PS00125 Serine/threonine specific protein phosphatases signature.
316401010709	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
316401010710	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
316401010711	active site
316401010712	Int/Topo IB signature motif; other site
316401010713	GMP synthase; Reviewed; Region: guaA; PRK00074
316401010714	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
316401010715	AMP/PPi binding site [chemical binding]; other site
316401010716	candidate oxyanion hole; other site
316401010717	catalytic triad [active]
316401010718	potential glutamine specificity residues [chemical binding]; other site
316401010719	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
316401010720	ATP Binding subdomain [chemical binding]; other site
316401010721	Ligand Binding sites [chemical binding]; other site
316401010722	Dimerization subdomain; other site
316401010723	PS00442 Glutamine amidotransferases class-I active site.
316401010724	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
316401010725	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
316401010726	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
316401010727	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
316401010728	active site
316401010729	PS00487 IMP dehydrogenase / GMP reductase signature.
316401010730	exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237
316401010731	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
316401010732	generic binding surface II; other site
316401010733	generic binding surface I; other site
316401010734	Protein of unknown function (DUF1407); Region: DUF1407; pfam07191
316401010735	GTP-binding protein Der; Reviewed; Region: PRK00093
316401010736	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
316401010737	G1 box; other site
316401010738	GTP/Mg2+ binding site [chemical binding]; other site
316401010739	Switch I region; other site
316401010740	G2 box; other site
316401010741	Switch II region; other site
316401010742	G3 box; other site
316401010743	G4 box; other site
316401010744	G5 box; other site
316401010745	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
316401010746	G1 box; other site
316401010747	GTP/Mg2+ binding site [chemical binding]; other site
316401010748	Switch I region; other site
316401010749	G2 box; other site
316401010750	G3 box; other site
316401010751	Switch II region; other site
316401010752	G4 box; other site
316401010753	G5 box; other site
316401010754	PS00017 ATP/GTP-binding site motif A (P-loop).
316401010755	PS00017 ATP/GTP-binding site motif A (P-loop).
316401010756	outer membrane biogenesis protein BamB; Provisional; Region: PRK11138
316401010757	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cd00216
316401010758	Trp docking motif [polypeptide binding]; other site
316401010759	active site
316401010760	Signal peptide predicted for ETEC2669 by SignalP 2.0 HMM (Signal peptide probability 0.830) with cleavage site probability 0.720 between residues 24 and 25
316401010761	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401010762	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
316401010763	1 probable transmembrane helix predicted for ETEC2670 by TMHMM2.0 at aa 24-43
316401010764	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
316401010765	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
316401010766	dimer interface [polypeptide binding]; other site
316401010767	motif 1; other site
316401010768	active site
316401010769	motif 2; other site
316401010770	motif 3; other site
316401010771	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
316401010772	anticodon binding site; other site
316401010773	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
316401010774	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
316401010775	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
316401010776	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
316401010777	cytoskeletal protein RodZ; Provisional; Region: PRK10856
316401010778	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
316401010779	non-specific DNA binding site [nucleotide binding]; other site
316401010780	salt bridge; other site
316401010781	sequence-specific DNA binding site [nucleotide binding]; other site
316401010782	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
316401010783	1 probable transmembrane helix predicted for ETEC2673 by TMHMM2.0 at aa 111-133
316401010784	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
316401010785	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316401010786	FeS/SAM binding site; other site
316401010787	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
316401010788	active site
316401010789	multimer interface [polypeptide binding]; other site
316401010790	PS00469 Nucleoside diphosphate kinases active site.
316401010791	penicillin-binding protein 1C; Provisional; Region: PRK11240
316401010792	Transglycosylase; Region: Transgly; pfam00912
316401010793	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
316401010794	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
316401010795	1 probable transmembrane helix predicted for ETEC2676 by TMHMM2.0 at aa 9-28
316401010796	Signal peptide predicted for ETEC2676 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.994 between residues 27 and 28
316401010797	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
316401010798	MG2 domain; Region: A2M_N; pfam01835
316401010799	Alpha-2-macroglobulin family; Region: A2M; pfam00207
316401010800	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
316401010801	surface patch; other site
316401010802	thioester region; other site
316401010803	specificity defining residues; other site
316401010804	PS00215 Mitochondrial energy transfer proteins signature.
316401010805	Signal peptide predicted for ETEC2677 by SignalP 2.0 HMM (Signal peptide probability 0.978) with cleavage site probability 0.748 between residues 21 and 22
316401010806	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401010807	3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493
316401010808	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
316401010809	active site residue [active]
316401010810	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
316401010811	active site residue [active]
316401010812	PS00380 Rhodanese signature 1.
316401010813	PS00683 Rhodanese C-terminal signature.
316401010814	enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611
316401010815	aminopeptidase B; Provisional; Region: PRK05015
316401010816	Peptidase; Region: DUF3663; pfam12404
316401010817	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
316401010818	interface (dimer of trimers) [polypeptide binding]; other site
316401010819	Substrate-binding/catalytic site; other site
316401010820	Zn-binding sites [ion binding]; other site
316401010821	PS00631 Cytosol aminopeptidase signature.
316401010822	hypothetical protein; Provisional; Region: PRK10721
316401010823	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
316401010824	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
316401010825	catalytic loop [active]
316401010826	iron binding site [ion binding]; other site
316401010827	PS00814 Adrenodoxin family, iron-sulfur binding region signature.
316401010828	chaperone protein HscA; Provisional; Region: hscA; PRK05183
316401010829	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
316401010830	nucleotide binding site [chemical binding]; other site
316401010831	putative NEF/HSP70 interaction site [polypeptide binding]; other site
316401010832	SBD interface [polypeptide binding]; other site
316401010833	PS01036 Heat shock hsp70 proteins family signature 3.
316401010834	PS00329 Heat shock hsp70 proteins family signature 2.
316401010835	PS00297 Heat shock hsp70 proteins family signature 1.
316401010836	co-chaperone HscB; Provisional; Region: hscB; PRK05014
316401010837	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
316401010838	HSP70 interaction site [polypeptide binding]; other site
316401010839	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
316401010840	iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502
316401010841	PS01152 Hypothetical hesB/yadR/yfhF family signature.
316401010842	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
316401010843	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
316401010844	trimerization site [polypeptide binding]; other site
316401010845	active site
316401010846	cysteine desulfurase; Provisional; Region: PRK14012
316401010847	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
316401010848	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
316401010849	catalytic residue [active]
316401010850	PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site.
316401010851	DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857
316401010852	Rrf2 family protein; Region: rrf2_super; TIGR00738
316401010853	PS01332 Uncharacterized protein family UPF0074 signature.
316401010854	tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114
316401010855	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
316401010856	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
316401010857	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
316401010858	active site
316401010859	dimerization interface [polypeptide binding]; other site
316401010860	PS00629 Inositol monophosphatase family signature 1.
316401010861	PS00630 Inositol monophosphatase family signature 2.
316401010862	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
316401010863	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
316401010864	1 probable transmembrane helix predicted for ETEC2691 by TMHMM2.0 at aa 21-40
316401010865	stationary phase inducible protein CsiE; Provisional; Region: PRK11564
316401010866	PRD domain; Region: PRD; pfam00874
316401010867	PRD domain; Region: PRD; pfam00874
316401010868	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
316401010869	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401010870	putative substrate translocation pore; other site
316401010871	12 probable transmembrane helices predicted for ETEC2693 by TMHMM2.0 at aa 9-31, 41-63, 70-89, 93-111, 132-154, 158-180, 207-229, 234-256, 269-288, 293-315, 328-350 and 354-371
316401010872	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
316401010873	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401010874	The C-terminal substrate binding domain of LysR-type transcriptional regulator HcaR in involved in 3-phenylpropionic acid catabolism, contains the type2 periplasmic binding fold; Region: PBP2_HcaR; cd08450
316401010875	putative dimerization interface [polypeptide binding]; other site
316401010876	putative substrate binding pocket [chemical binding]; other site
316401010877	PS00044 Bacterial regulatory proteins, lysR family signature.
316401010878	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
316401010879	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
316401010880	iron-sulfur cluster [ion binding]; other site
316401010881	[2Fe-2S] cluster binding site [ion binding]; other site
316401010882	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
316401010883	beta subunit interface [polypeptide binding]; other site
316401010884	alpha subunit interface [polypeptide binding]; other site
316401010885	active site
316401010886	substrate binding site [chemical binding]; other site
316401010887	Fe binding site [ion binding]; other site
316401010888	PS00570 Bacterial ring hydroxylating dioxygenases alpha-subunit signature.
316401010889	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
316401010890	inter-subunit interface; other site
316401010891	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
316401010892	[2Fe-2S] cluster binding site [ion binding]; other site
316401010893	2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200
316401010894	cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB)-like, classical (c) SDRs; Region: BphB-like_SDR_c; cd05348
316401010895	NAD binding site [chemical binding]; other site
316401010896	active site
316401010897	PS00061 Short-chain dehydrogenases/reductases family signature.
316401010898	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
316401010899	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
316401010900	Signal peptide predicted for ETEC2699 by SignalP 2.0 HMM (Signal peptide probability 0.905) with cleavage site probability 0.781 between residues 18 and 19
316401010901	Predicted membrane protein [Function unknown]; Region: COG2259
316401010902	4 probable transmembrane helices predicted for ETEC2700 by TMHMM2.0 at aa 39-58, 78-100, 105-124 and 144-161
316401010903	aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021
316401010904	active site
316401010905	catalytic residues [active]
316401010906	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
316401010907	L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239
316401010908	putative NAD(P) binding site [chemical binding]; other site
316401010909	catalytic Zn binding site [ion binding]; other site
316401010910	PS00059 Zinc-containing alcohol dehydrogenases signature.
316401010911	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
316401010912	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
316401010913	TM-ABC transporter signature motif; other site
316401010914	8 probable transmembrane helices predicted for ETEC2703 by TMHMM2.0 at aa 27-49, 61-83, 103-125, 127-149, 169-191, 224-246, 278-300 and 307-324
316401010915	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
316401010916	ABC transporter; Region: ABC_tran; pfam00005
316401010917	Q-loop/lid; other site
316401010918	ABC transporter signature motif; other site
316401010919	Walker B; other site
316401010920	D-loop; other site
316401010921	H-loop/switch region; other site
316401010922	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
316401010923	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
316401010924	PS00211 ABC transporters family signature.
316401010925	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
316401010926	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
316401010927	ligand binding site [chemical binding]; other site
316401010928	Signal peptide predicted for ETEC2705 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 26 and 27
316401010929	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
316401010930	TPR motif; other site
316401010931	Tetratricopeptide repeat; Region: TPR_16; pfam13432
316401010932	binding surface
316401010933	TPR repeat; Region: TPR_11; pfam13414
316401010934	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
316401010935	TPR motif; other site
316401010936	binding surface
316401010937	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
316401010938	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
316401010939	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
316401010940	nucleotide binding site [chemical binding]; other site
316401010941	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
316401010942	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
316401010943	dimer interface [polypeptide binding]; other site
316401010944	active site
316401010945	glycine-pyridoxal phosphate binding site [chemical binding]; other site
316401010946	folate binding site [chemical binding]; other site
316401010947	PS00096 Serine hydroxymethyltransferase pyridoxal-phosphate attachment site.
316401010948	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
316401010949	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
316401010950	heme-binding site [chemical binding]; other site
316401010951	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
316401010952	FAD binding pocket [chemical binding]; other site
316401010953	FAD binding motif [chemical binding]; other site
316401010954	phosphate binding motif [ion binding]; other site
316401010955	beta-alpha-beta structure motif; other site
316401010956	NAD binding pocket [chemical binding]; other site
316401010957	Heme binding  pocket [chemical binding]; other site
316401010958	nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858
316401010959	Nitrogen regulatory protein P-II; Region: P-II; smart00938
316401010960	PS00638 P-II protein C-terminal region signature.
316401010961	PS00496 P-II protein urydylation site.
316401010962	response regulator GlrR; Provisional; Region: PRK15115
316401010963	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316401010964	active site
316401010965	phosphorylation site [posttranslational modification]
316401010966	intermolecular recognition site; other site
316401010967	dimerization interface [polypeptide binding]; other site
316401010968	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316401010969	Walker A motif; other site
316401010970	ATP binding site [chemical binding]; other site
316401010971	Walker B motif; other site
316401010972	arginine finger; other site
316401010973	PS00688 Sigma-54 interaction domain C-terminal part signature.
316401010974	PS00676 Sigma-54 interaction domain ATP-binding region B signature.
316401010975	PS00675 Sigma-54 interaction domain ATP-binding region A signature.
316401010976	hypothetical protein; Provisional; Region: PRK10722
316401010977	Signal peptide predicted for ETEC2712 by SignalP 2.0 HMM (Signal peptide probability 0.810) with cleavage site probability 0.514 between residues 31 and 32
316401010978	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401010979	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
316401010980	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316401010981	dimer interface [polypeptide binding]; other site
316401010982	phosphorylation site [posttranslational modification]
316401010983	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316401010984	ATP binding site [chemical binding]; other site
316401010985	Mg2+ binding site [ion binding]; other site
316401010986	G-X-G motif; other site
316401010987	2 probable transmembrane helices predicted for ETEC2713 by TMHMM2.0 at aa 15-34 and 175-197
316401010988	Signal peptide predicted for ETEC2713 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.948 between residues 30 and 31
316401010989	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
316401010990	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
316401010991	dimerization interface [polypeptide binding]; other site
316401010992	ATP binding site [chemical binding]; other site
316401010993	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
316401010994	dimerization interface [polypeptide binding]; other site
316401010995	ATP binding site [chemical binding]; other site
316401010996	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
316401010997	putative active site [active]
316401010998	catalytic triad [active]
316401010999	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
316401011000	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
316401011001	substrate binding pocket [chemical binding]; other site
316401011002	membrane-bound complex binding site; other site
316401011003	hinge residues; other site
316401011004	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
316401011005	N-acetyl-D-glucosamine binding site [chemical binding]; other site
316401011006	catalytic residue [active]
316401011007	PS00922 Prokaryotic transglycosylases signature.
316401011008	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
316401011009	nucleoside/Zn binding site; other site
316401011010	dimer interface [polypeptide binding]; other site
316401011011	catalytic motif [active]
316401011012	PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature.
316401011013	hypothetical protein; Provisional; Region: PRK11590
316401011014	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
316401011015	1 probable transmembrane helix predicted for ETEC2717 by TMHMM2.0 at aa 35-54
316401011016	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
316401011017	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557
316401011018	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
316401011019	putative active site [active]
316401011020	1 probable transmembrane helix predicted for ETEC2720 by TMHMM2.0 at aa 10-32
316401011021	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
316401011022	DNA-binding interface [nucleotide binding]; DNA binding site
316401011023	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
316401011024	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
316401011025	catalytic residues [active]
316401011026	catalytic nucleophile [active]
316401011027	PS00398 Site-specific recombinases signature 2.
316401011028	PS00397 Site-specific recombinases active site.
316401011029	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
316401011030	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
316401011031	Protein of unknown function (DUF2612); Region: DUF2612; pfam11041
316401011032	Baseplate J-like protein; Region: Baseplate_J; cl01294
316401011033	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
316401011034	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
316401011035	3 probable transmembrane helices predicted for ETEC2732 by TMHMM2.0 at aa 46-68, 78-100 and 160-182
316401011036	Signal peptide predicted for ETEC2733 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.947 between residues 18 and 19
316401011037	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
316401011038	virion protein; Provisional; Region: V; PHA02564
316401011039	Protein of unknown function (DUF3277); Region: DUF3277; pfam11681
316401011040	Protein of unknown function (DUF3383); Region: DUF3383; pfam11863
316401011041	Guanylyl transferase CofC like; Region: CofC; cl17472
316401011042	Superfamily II helicase, archaea-specific [General function prediction only]; Region: COG1202
316401011043	Protein of unknown function (DUF4054); Region: DUF4054; pfam13262
316401011044	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834
316401011045	Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950
316401011046	Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979
316401011047	phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555
316401011048	Protein of unknown function (DUF1073); Region: DUF1073; pfam06381
316401011049	Terminase small subunit; Region: Terminase_2; pfam03592
316401011050	PS00217 Sugar transport proteins signature 2.
316401011051	1 probable transmembrane helix predicted for ETEC2753 by TMHMM2.0 at aa 7-24
316401011052	Signal peptide predicted for ETEC2753 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.558 between residues 23 and 24
316401011053	The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes.  But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736
316401011054	N-acetyl-D-glucosamine binding site [chemical binding]; other site
316401011055	catalytic residue [active]
316401011056	Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938
316401011057	3 probable transmembrane helices predicted for ETEC2755 by TMHMM2.0 at aa 28-50, 57-76 and 80-99
316401011058	Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530
316401011059	Virulence-associated protein E; Region: VirE; pfam05272
316401011060	PS00017 ATP/GTP-binding site motif A (P-loop).
316401011061	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
316401011062	non-specific DNA binding site [nucleotide binding]; other site
316401011063	Predicted transcriptional regulator [Transcription]; Region: COG2932
316401011064	salt bridge; other site
316401011065	sequence-specific DNA binding site [nucleotide binding]; other site
316401011066	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
316401011067	Catalytic site [active]
316401011068	1 probable transmembrane helix predicted for ETEC2762 by TMHMM2.0 at aa 35-57
316401011069	Protein of unknown function (DUF2800); Region: DUF2800; pfam10926
316401011070	Protein of unknown function (DUF2815); Region: DUF2815; pfam10991
316401011071	3 probable transmembrane helices predicted for ETEC2766 by TMHMM2.0 at aa 13-32, 135-157 and 164-186
316401011072	Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626
316401011073	active site
316401011074	DNA binding site [nucleotide binding]
316401011075	catalytic site [active]
316401011076	VRR-NUC domain; Region: VRR_NUC; pfam08774
316401011077	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
316401011078	potential frameshift: common BLAST hit: gi|260845245|ref|YP_003223023.1| phage-related DNA helicase
316401011079	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
316401011080	PS00017 ATP/GTP-binding site motif A (P-loop).
316401011081	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
316401011082	nucleotide binding region [chemical binding]; other site
316401011083	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
316401011084	ATP-binding site [chemical binding]; other site
316401011085	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
316401011086	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
316401011087	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401011088	holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516
316401011089	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
316401011090	active site
316401011091	hydrophilic channel; other site
316401011092	dimerization interface [polypeptide binding]; other site
316401011093	catalytic residues [active]
316401011094	active site lid [active]
316401011095	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
316401011096	Recombination protein O N terminal; Region: RecO_N; pfam11967
316401011097	Recombination protein O C terminal; Region: RecO_C; pfam02565
316401011098	GTPase Era; Reviewed; Region: era; PRK00089
316401011099	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
316401011100	G1 box; other site
316401011101	GTP/Mg2+ binding site [chemical binding]; other site
316401011102	Switch I region; other site
316401011103	G2 box; other site
316401011104	Switch II region; other site
316401011105	G3 box; other site
316401011106	G4 box; other site
316401011107	G5 box; other site
316401011108	KH domain; Region: KH_2; pfam07650
316401011109	PS00017 ATP/GTP-binding site motif A (P-loop).
316401011110	ribonuclease III; Reviewed; Region: rnc; PRK00102
316401011111	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
316401011112	dimerization interface [polypeptide binding]; other site
316401011113	active site
316401011114	metal binding site [ion binding]; metal-binding site
316401011115	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
316401011116	dsRNA binding site [nucleotide binding]; other site
316401011117	PS00517 Ribonuclease III family signature.
316401011118	signal peptidase I; Provisional; Region: PRK10861
316401011119	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
316401011120	Catalytic site [active]
316401011121	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
316401011122	PS00761 Signal peptidases I signature 3.
316401011123	PS00760 Signal peptidases I lysine active site.
316401011124	PS00501 Signal peptidases I serine active site.
316401011125	2 probable transmembrane helices predicted for ETEC2781 by TMHMM2.0 at aa 5-27 and 60-82
316401011126	GTP-binding protein LepA; Provisional; Region: PRK05433
316401011127	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
316401011128	G1 box; other site
316401011129	putative GEF interaction site [polypeptide binding]; other site
316401011130	GTP/Mg2+ binding site [chemical binding]; other site
316401011131	Switch I region; other site
316401011132	G2 box; other site
316401011133	G3 box; other site
316401011134	Switch II region; other site
316401011135	G4 box; other site
316401011136	G5 box; other site
316401011137	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
316401011138	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
316401011139	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
316401011140	PS00301 GTP-binding elongation factors signature.
316401011141	PS00017 ATP/GTP-binding site motif A (P-loop).
316401011142	SoxR reducing system protein RseC; Provisional; Region: PRK10862
316401011143	2 probable transmembrane helices predicted for ETEC2783 by TMHMM2.0 at aa 73-95 and 99-121
316401011144	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401011145	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
316401011146	anti-sigma E factor; Provisional; Region: rseB; PRK09455
316401011147	Signal peptide predicted for ETEC2784 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.876 between residues 23 and 24
316401011148	anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863
316401011149	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
316401011150	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
316401011151	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
316401011152	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
316401011153	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
316401011154	DNA binding residues [nucleotide binding]
316401011155	PS01063 Sigma-70 factors ECF subfamily signature.
316401011156	L-aspartate oxidase; Provisional; Region: PRK09077
316401011157	L-aspartate oxidase; Provisional; Region: PRK06175
316401011158	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
316401011159	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
316401011160	Methyltransferase domain; Region: Methyltransf_26; pfam13659
316401011161	PS00092 N-6 Adenine-specific DNA methylases signature.
316401011162	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
316401011163	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
316401011164	ATP binding site [chemical binding]; other site
316401011165	Mg++ binding site [ion binding]; other site
316401011166	motif III; other site
316401011167	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
316401011168	nucleotide binding region [chemical binding]; other site
316401011169	ATP-binding site [chemical binding]; other site
316401011170	PS00017 ATP/GTP-binding site motif A (P-loop).
316401011171	PS00039 DEAD-box subfamily ATP-dependent helicases signature.
316401011172	Transcriptional regulator [Transcription]; Region: LysR; COG0583
316401011173	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401011174	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
316401011175	dimerization interface [polypeptide binding]; other site
316401011176	PS00044 Bacterial regulatory proteins, lysR family signature.
316401011177	cysteine/O-acetylserine exporter; Provisional; Region: PRK10323
316401011178	6 probable transmembrane helices predicted for ETEC2791 by TMHMM2.0 at aa 10-32, 44-66, 70-92, 105-127, 142-164 and 177-194
316401011179	autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127
316401011180	PS00850 Glycine radical signature.
316401011181	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
316401011182	ligand binding site [chemical binding]; other site
316401011183	active site
316401011184	UGI interface [polypeptide binding]; other site
316401011185	catalytic site [active]
316401011186	PS00130 Uracil-DNA glycosylase signature.
316401011187	putative methyltransferase; Provisional; Region: PRK10864
316401011188	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
316401011189	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
316401011190	PS00017 ATP/GTP-binding site motif A (P-loop).
316401011191	thioredoxin 2; Provisional; Region: PRK10996
316401011192	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
316401011193	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
316401011194	catalytic residues [active]
316401011195	PS00194 Thioredoxin family active site.
316401011196	Uncharacterized conserved protein [Function unknown]; Region: COG3148
316401011197	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
316401011198	CoA binding domain; Region: CoA_binding_2; pfam13380
316401011199	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
316401011200	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
316401011201	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
316401011202	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
316401011203	phosphatidylserine synthase; Provisional; Region: pssA; PRK09428
316401011204	Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134
316401011205	domain interface [polypeptide binding]; other site
316401011206	putative active site [active]
316401011207	catalytic site [active]
316401011208	Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136
316401011209	domain interface [polypeptide binding]; other site
316401011210	putative active site [active]
316401011211	catalytic site [active]
316401011212	lipoprotein; Provisional; Region: PRK10759
316401011213	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
316401011214	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401011215	putative substrate translocation pore; other site
316401011216	12 probable transmembrane helices predicted for ETEC2800 by TMHMM2.0 at aa 21-43, 62-84, 96-113, 118-140, 160-182, 197-214, 244-266, 281-303, 310-327, 337-359, 372-394 and 404-423
316401011217	PS00216 Sugar transport proteins signature 1.
316401011218	PS00217 Sugar transport proteins signature 2.
316401011219	protein disaggregation chaperone; Provisional; Region: PRK10865
316401011220	Clp amino terminal domain; Region: Clp_N; pfam02861
316401011221	Clp amino terminal domain; Region: Clp_N; pfam02861
316401011222	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316401011223	Walker A motif; other site
316401011224	ATP binding site [chemical binding]; other site
316401011225	Walker B motif; other site
316401011226	arginine finger; other site
316401011227	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316401011228	Walker A motif; other site
316401011229	ATP binding site [chemical binding]; other site
316401011230	Walker B motif; other site
316401011231	arginine finger; other site
316401011232	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
316401011233	PS00871 Chaperonins clpA/B signature 2.
316401011234	PS00017 ATP/GTP-binding site motif A (P-loop).
316401011235	PS00017 ATP/GTP-binding site motif A (P-loop).
316401011236	PS00870 Chaperonins clpA/B signature 1.
316401011237	PS00017 ATP/GTP-binding site motif A (P-loop).
316401011238	hypothetical protein; Provisional; Region: PRK10723
316401011239	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
316401011240	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
316401011241	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
316401011242	RNA binding surface [nucleotide binding]; other site
316401011243	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
316401011244	active site
316401011245	PS01129 Rlu family of pseudouridine synthase signature.
316401011246	outer membrane biogenesis protein BamD; Provisional; Region: PRK10866
316401011247	Protein of unknown function (DUF3897); Region: DUF3897; cl17494
316401011248	Signal peptide predicted for ETEC2804 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.476 between residues 23 and 24
316401011249	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401011250	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
316401011251	30S subunit binding site; other site
316401011252	bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622
316401011253	chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797
316401011254	Prephenate dehydratase; Region: PDT; pfam00800
316401011255	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
316401011256	putative L-Phe binding site [chemical binding]; other site
316401011257	PS00857 Prephenate dehydratase signature 1.
316401011258	PS00858 Prephenate dehydratase signature 2.
316401011259	bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199
316401011260	chorismate mutase domain of T-protein; Region: CM_T; TIGR01799
316401011261	prephenate dehydrogenase; Validated; Region: PRK08507
316401011262	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
316401011263	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
316401011264	lipoprotein; Provisional; Region: PRK11443
316401011265	Protein of unknown function (DUF2799); Region: DUF2799; pfam10973
316401011266	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401011267	PS00017 ATP/GTP-binding site motif A (P-loop).
316401011268	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
316401011269	Signal peptide predicted for ETEC2810 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 22 and 23
316401011270	putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966
316401011271	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316401011272	metal binding site [ion binding]; metal-binding site
316401011273	active site
316401011274	I-site; other site
316401011275	Signal peptide predicted for ETEC2811 by SignalP 2.0 HMM (Signal peptide probability 0.921) with cleavage site probability 0.554 between residues 49 and 50
316401011276	2 probable transmembrane helices predicted for ETEC2811 by TMHMM2.0 at aa 23-45 and 155-177
316401011277	putative outer membrane lipoprotein; Provisional; Region: PRK09967
316401011278	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
316401011279	ligand binding site [chemical binding]; other site
316401011280	Signal peptide predicted for ETEC2812 by SignalP 2.0 HMM (Signal peptide probability 0.604) with cleavage site probability 0.535 between residues 24 and 25
316401011281	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401011282	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
316401011283	PS01015 Ribosomal protein L19 signature.
316401011284	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
316401011285	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
316401011286	RimM N-terminal domain; Region: RimM; pfam01782
316401011287	PRC-barrel domain; Region: PRC; pfam05239
316401011288	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
316401011289	PS00732 Ribosomal protein S16 signature.
316401011290	signal recognition particle protein; Provisional; Region: PRK10867
316401011291	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
316401011292	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
316401011293	P loop; other site
316401011294	GTP binding site [chemical binding]; other site
316401011295	Signal peptide binding domain; Region: SRP_SPB; pfam02978
316401011296	PS00300 SRP54-type proteins GTP-binding domain signature.
316401011297	PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide.
316401011298	PS00017 ATP/GTP-binding site motif A (P-loop).
316401011299	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137
316401011300	8 probable transmembrane helices predicted for ETEC2818 by TMHMM2.0 at aa 13-35, 55-74, 87-109, 114-136, 149-171, 201-223, 235-252 and 262-279
316401011301	hypothetical protein; Provisional; Region: PRK11573
316401011302	Domain of unknown function DUF21; Region: DUF21; pfam01595
316401011303	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
316401011304	Transporter associated domain; Region: CorC_HlyC; smart01091
316401011305	3 probable transmembrane helices predicted for ETEC2819 by TMHMM2.0 at aa 32-54, 64-82 and 94-116
316401011306	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
316401011307	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
316401011308	dimer interface [polypeptide binding]; other site
316401011309	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
316401011310	PS01071 grpE protein signature.
316401011311	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378
316401011312	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
316401011313	recombination and repair protein; Provisional; Region: PRK10869
316401011314	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
316401011315	Walker A/P-loop; other site
316401011316	ATP binding site [chemical binding]; other site
316401011317	Q-loop/lid; other site
316401011318	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
316401011319	Q-loop/lid; other site
316401011320	ABC transporter signature motif; other site
316401011321	Walker B; other site
316401011322	D-loop; other site
316401011323	H-loop/switch region; other site
316401011324	PS00017 ATP/GTP-binding site motif A (P-loop).
316401011325	outer membrane biogenesis protein BamE; Provisional; Region: PRK11548
316401011326	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
316401011327	Signal peptide predicted for ETEC2823 by SignalP 2.0 HMM (Signal peptide probability 0.981) with cleavage site probability 0.424 between residues 22 and 23
316401011328	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401011329	PS00018 EF-hand calcium-binding domain.
316401011330	hypothetical protein; Validated; Region: PRK01777
316401011331	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
316401011332	putative coenzyme Q binding site [chemical binding]; other site
316401011333	PS00036 bZIP transcription factors basic domain signature.
316401011334	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
316401011335	SmpB-tmRNA interface; other site
316401011336	PS01317 Protein smpB signature.
316401011337	integrase; Provisional; Region: PRK09692
316401011338	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
316401011339	active site
316401011340	Int/Topo IB signature motif; other site
316401011341	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
316401011342	substrate binding site [chemical binding]; other site
316401011343	activation loop (A-loop); other site
316401011344	AAA domain; Region: AAA_11; pfam13086
316401011345	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
316401011346	Walker A motif; other site
316401011347	ATP binding site [chemical binding]; other site
316401011348	AAA domain; Region: AAA_12; pfam13087
316401011349	PS00017 ATP/GTP-binding site motif A (P-loop).
316401011350	Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar5; cd09133
316401011351	PLD-like domain; Region: PLDc_2; pfam13091
316401011352	putative active site [active]
316401011353	putative catalytic site [active]
316401011354	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
316401011355	putative active site [active]
316401011356	catalytic site [active]
316401011357	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
316401011358	PS00190 Cytochrome c family heme-binding site signature.
316401011359	2 probable transmembrane helices predicted for ETEC2835 by TMHMM2.0 at aa 29-51 and 56-78
316401011360	lipoprotein NlpI; Provisional; Region: PRK11189
316401011361	Signal peptide predicted for ETEC2836 by SignalP 2.0 HMM (Signal peptide probability 0.992) with cleavage site probability 0.660 between residues 22 and 23
316401011362	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401011363	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401011364	1 probable transmembrane helix predicted for ETEC2838 by TMHMM2.0 at aa 34-53
316401011365	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4688
316401011366	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
316401011367	active site
316401011368	catalytic residues [active]
316401011369	DNA binding site [nucleotide binding]
316401011370	Int/Topo IB signature motif; other site
316401011371	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
316401011372	active site
316401011373	catalytic residues [active]
316401011374	DNA binding site [nucleotide binding]
316401011375	Int/Topo IB signature motif; other site
316401011376	Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468
316401011377	hypothetical protein; Provisional; Region: PRK09945
316401011378	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343
316401011379	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
316401011380	Autotransporter beta-domain; Region: Autotransporter; pfam03797
316401011381	1 probable transmembrane helix predicted for ETEC2845 by TMHMM2.0 at aa 13-35
316401011382	Signal peptide predicted for ETEC2845 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.994 between residues 29 and 30
316401011383	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
316401011384	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
316401011385	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
316401011386	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
316401011387	PS00017 ATP/GTP-binding site motif A (P-loop).
316401011388	Similar to Clostridium acetobutylicum AmyA alpha-amylase precursor (ec 3.2.1.1) (1,4-alpha-d-glucan glucanohydrolase). UniProt:P23671 (760 aa) fasta scores: E()=0.019, 26.126% id in 111 aa, and to Escherichia coli. YgaQ UniProt:P76616 (EMBL:U00096 (750 aa) fasta scores: E()=8.5e-90, 99.561% id in 228 aa
316401011389	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250
316401011390	substrate binding pocket [chemical binding]; other site
316401011391	active site
316401011392	iron coordination sites [ion binding]; other site
316401011393	Predicted dehydrogenase [General function prediction only]; Region: COG0579
316401011394	hydroxyglutarate oxidase; Provisional; Region: PRK11728
316401011395	succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241
316401011396	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
316401011397	tetramerization interface [polypeptide binding]; other site
316401011398	NAD(P) binding site [chemical binding]; other site
316401011399	catalytic residues [active]
316401011400	PS00687 Aldehyde dehydrogenases glutamic acid active site.
316401011401	PS00070 Aldehyde dehydrogenases cysteine active site.
316401011402	4-aminobutyrate aminotransferase; Validated; Region: PRK08088
316401011403	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
316401011404	inhibitor-cofactor binding pocket; inhibition site
316401011405	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316401011406	catalytic residue [active]
316401011407	PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site.
316401011408	gamma-aminobutyrate transporter; Provisional; Region: PRK10197
316401011409	12 probable transmembrane helices predicted for ETEC2860 by TMHMM2.0 at aa 19-41, 46-65, 86-108, 123-145, 152-174, 202-224, 245-267, 287-309, 335-357, 362-381, 401-423 and 427-449
316401011410	PS00218 Amino acid permeases signature.
316401011411	DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534
316401011412	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
316401011413	DNA-binding site [nucleotide binding]; DNA binding site
316401011414	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
316401011415	PS00043 Bacterial regulatory proteins, gntR family signature.
316401011416	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
316401011417	bacterial OsmY and nodulation domain; Region: BON; smart00749
316401011418	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
316401011419	Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401
316401011420	2 probable transmembrane helices predicted for ETEC2863 by TMHMM2.0 at aa 2-20 and 25-47
316401011421	PS01309 Uncharacterized protein family UPF0057 signature.
316401011422	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
316401011423	dimerization interface [polypeptide binding]; other site
316401011424	putative DNA binding site [nucleotide binding]; other site
316401011425	Transcriptional regulators [Transcription]; Region: MarR; COG1846
316401011426	putative Zn2+ binding site [ion binding]; other site
316401011427	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527
316401011428	active site residue [active]
316401011429	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
316401011430	PS00287 Cysteine proteases inhibitors signature.
316401011431	2 probable transmembrane helices predicted for ETEC2865 by TMHMM2.0 at aa 119-141 and 146-165
316401011432	DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328
316401011433	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
316401011434	Protein of unknown function (DUF1144); Region: DUF1144; pfam06610
316401011435	4 probable transmembrane helices predicted for ETEC2867 by TMHMM2.0 at aa 16-38, 42-61, 82-104 and 110-132
316401011436	hypothetical protein; Provisional; Region: PRK10556
316401011437	hypothetical protein; Provisional; Region: PRK10132
316401011438	1 probable transmembrane helix predicted for ETEC2869 by TMHMM2.0 at aa 91-110
316401011439	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
316401011440	catalytic residues [active]
316401011441	PS00190 Cytochrome c family heme-binding site signature.
316401011442	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
316401011443	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
316401011444	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
316401011445	Class I ribonucleotide reductase; Region: RNR_I; cd01679
316401011446	active site
316401011447	dimer interface [polypeptide binding]; other site
316401011448	catalytic residues [active]
316401011449	effector binding site; other site
316401011450	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
316401011451	PS00089 Ribonucleotide reductase large subunit signature.
316401011452	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
316401011453	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
316401011454	dimer interface [polypeptide binding]; other site
316401011455	putative radical transfer pathway; other site
316401011456	diiron center [ion binding]; other site
316401011457	tyrosyl radical; other site
316401011458	PS00368 Ribonucleotide reductase small subunit signature.
316401011459	glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070
316401011460	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
316401011461	Walker A/P-loop; other site
316401011462	ATP binding site [chemical binding]; other site
316401011463	Q-loop/lid; other site
316401011464	ABC transporter signature motif; other site
316401011465	Walker B; other site
316401011466	D-loop; other site
316401011467	H-loop/switch region; other site
316401011468	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
316401011469	PS00017 ATP/GTP-binding site motif A (P-loop).
316401011470	PS00211 ABC transporters family signature.
316401011471	glycine betaine transporter membrane protein; Provisional; Region: PRK10952
316401011472	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401011473	dimer interface [polypeptide binding]; other site
316401011474	conserved gate region; other site
316401011475	putative PBP binding loops; other site
316401011476	ABC-ATPase subunit interface; other site
316401011477	6 probable transmembrane helices predicted for ETEC2875 by TMHMM2.0 at aa 94-116, 120-142, 149-171, 197-219, 272-294 and 298-320
316401011478	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
316401011479	glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119
316401011480	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
316401011481	Signal peptide predicted for ETEC2876 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 21 and 22
316401011482	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
316401011483	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401011484	Signal peptide predicted for ETEC2877 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.590 between residues 25 and 26
316401011485	10 probable transmembrane helices predicted for ETEC2877 by TMHMM2.0 at aa 7-29, 44-66, 78-100, 104-126, 133-155, 160-182, 217-239, 249-271, 284-306 and 362-384
316401011486	PS00017 ATP/GTP-binding site motif A (P-loop).
316401011487	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
316401011488	5 probable transmembrane helices predicted for ETEC2878 by TMHMM2.0 at aa 22-44, 59-81, 139-161, 171-193 and 205-238
316401011489	putative L-valine exporter; Provisional; Region: PRK10408
316401011490	3 probable transmembrane helices predicted for ETEC2879 by TMHMM2.0 at aa 5-24, 37-59 and 90-109
316401011491	transcriptional repressor MprA; Provisional; Region: PRK10870
316401011492	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
316401011493	PS01117 Bacterial regulatory proteins, marR family signature.
316401011494	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
316401011495	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
316401011496	HlyD family secretion protein; Region: HlyD_3; pfam13437
316401011497	Signal peptide predicted for ETEC2881 by SignalP 2.0 HMM (Signal peptide probability 0.661) with cleavage site probability 0.645 between residues 37 and 38
316401011498	1 probable transmembrane helix predicted for ETEC2881 by TMHMM2.0 at aa 23-45
316401011499	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
316401011500	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401011501	putative substrate translocation pore; other site
316401011502	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401011503	13 probable transmembrane helices predicted for ETEC2882 by TMHMM2.0 at aa 13-35, 50-72, 79-101, 106-128, 140-162, 167-189, 201-219, 234-251, 270-292, 302-324, 336-353, 368-390 and 480-498
316401011504	S-ribosylhomocysteinase; Provisional; Region: PRK02260
316401011505	glutamate--cysteine ligase; Provisional; Region: PRK02107
316401011506	Predicted membrane protein [Function unknown]; Region: COG1238
316401011507	4 probable transmembrane helices predicted for ETEC2885 by TMHMM2.0 at aa 15-37, 42-64, 84-106 and 113-135
316401011508	Signal peptide predicted for ETEC2885 by SignalP 2.0 HMM (Signal peptide probability 0.970) with cleavage site probability 0.859 between residues 18 and 19
316401011509	fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725
316401011510	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
316401011511	motif II; other site
316401011512	carbon storage regulator; Provisional; Region: PRK01712
316401011513	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
316401011514	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
316401011515	motif 1; other site
316401011516	active site
316401011517	motif 2; other site
316401011518	motif 3; other site
316401011519	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
316401011520	DHHA1 domain; Region: DHHA1; pfam02272
316401011521	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
316401011522	recombination regulator RecX; Reviewed; Region: recX; PRK00117
316401011523	recombinase A; Provisional; Region: recA; PRK09354
316401011524	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
316401011525	hexamer interface [polypeptide binding]; other site
316401011526	Walker A motif; other site
316401011527	ATP binding site [chemical binding]; other site
316401011528	Walker B motif; other site
316401011529	PS00321 recA signature.
316401011530	PS00017 ATP/GTP-binding site motif A (P-loop).
316401011531	PS00017 ATP/GTP-binding site motif A (P-loop).
316401011532	hypothetical protein; Validated; Region: PRK03661
316401011533	Transglycosylase SLT domain; Region: SLT_2; pfam13406
316401011534	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
316401011535	N-acetyl-D-glucosamine binding site [chemical binding]; other site
316401011536	Signal peptide predicted for ETEC2892 by SignalP 2.0 HMM (Signal peptide probability 0.933) with cleavage site probability 0.840 between residues 21 and 22
316401011537	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401011538	PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821
316401011539	3 probable transmembrane helices predicted for ETEC2893 by TMHMM2.0 at aa 26-48, 68-90 and 139-161
316401011540	PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825
316401011541	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
316401011542	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
316401011543	PS00107 Protein kinases ATP-binding region signature.
316401011544	4 probable transmembrane helices predicted for ETEC2894 by TMHMM2.0 at aa 177-199, 214-236, 243-265 and 296-318
316401011545	PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377
316401011546	sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384
316401011547	Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322
316401011548	putative NAD(P) binding site [chemical binding]; other site
316401011549	active site
316401011550	PS00061 Short-chain dehydrogenases/reductases family signature.
316401011551	DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234
316401011552	Signal peptide predicted for ETEC2897 by SignalP 2.0 HMM (Signal peptide probability 0.845) with cleavage site probability 0.828 between residues 20 and 21
316401011553	1 probable transmembrane helix predicted for ETEC2897 by TMHMM2.0 at aa 2-24
316401011554	DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434
316401011555	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
316401011556	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
316401011557	PS00894 Bacterial regulatory proteins, deoR family signature.
316401011558	D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543
316401011559	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
316401011560	putative active site [active]
316401011561	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
316401011562	PS00178 Aminoacyl-transfer RNA synthetases class-I signature.
316401011563	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
316401011564	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
316401011565	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316401011566	Walker A motif; other site
316401011567	ATP binding site [chemical binding]; other site
316401011568	Walker B motif; other site
316401011569	arginine finger; other site
316401011570	PS00688 Sigma-54 interaction domain C-terminal part signature.
316401011571	PS00676 Sigma-54 interaction domain ATP-binding region B signature.
316401011572	PS00675 Sigma-54 interaction domain ATP-binding region A signature.
316401011573	anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452
316401011574	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
316401011575	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
316401011576	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
316401011577	iron binding site [ion binding]; other site
316401011578	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
316401011579	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
316401011580	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
316401011581	Acylphosphatase; Region: Acylphosphatase; pfam00708
316401011582	HypF finger; Region: zf-HYPF; pfam07503
316401011583	HypF finger; Region: zf-HYPF; pfam07503
316401011584	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
316401011585	PS00150 Acylphosphatase signature 1.
316401011586	formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330
316401011587	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
316401011588	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401011589	Transcriptional regulators [Transcription]; Region: PurR; COG1609
316401011590	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
316401011591	DNA binding site [nucleotide binding]
316401011592	domain linker motif; other site
316401011593	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
316401011594	dimerization interface (closed form) [polypeptide binding]; other site
316401011595	ligand binding site [chemical binding]; other site
316401011596	PS00356 Bacterial regulatory proteins, lacI family signature.
316401011597	PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796
316401011598	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
316401011599	active site turn [active]
316401011600	phosphorylation site [posttranslational modification]
316401011601	PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852
316401011602	PS01035 PTS EIIB domains cysteine phosphorylation site signature.
316401011603	8 probable transmembrane helices predicted for ETEC2906 by TMHMM2.0 at aa 102-124, 149-171, 178-197, 212-234, 255-277, 282-304, 389-411 and 434-456
316401011604	cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852
316401011605	beta-galactosidase; Region: BGL; TIGR03356
316401011606	PS00653 Glycosyl hydrolases family 1 N-terminal signature.
316401011607	PS00572 Glycosyl hydrolases family 1 active site.
316401011608	Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067
316401011609	nickel binding site [ion binding]; other site
316401011610	formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084
316401011611	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
316401011612	PS01150 Respiratory-chain NADH dehydrogenase 20 Kd subunit signature.
316401011613	formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387
316401011614	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
316401011615	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401011616	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401011617	Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262
316401011618	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
316401011619	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
316401011620	PS00535 Respiratory chain NADH dehydrogenase 49 Kd subunit signature.
316401011621	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
316401011622	NADH dehydrogenase; Region: NADHdh; cl00469
316401011623	8 probable transmembrane helices predicted for ETEC2913 by TMHMM2.0 at aa 7-29, 69-91, 98-116, 131-153, 166-188, 218-240, 252-274 and 289-306
316401011624	PS00668 Respiratory-chain NADH dehydrogenase subunit 1 signature 2.
316401011625	PS00667 Respiratory-chain NADH dehydrogenase subunit 1 signature 1.
316401011626	formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042
316401011627	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
316401011628	14 probable transmembrane helices predicted for ETEC2914 by TMHMM2.0 at aa 5-27, 47-69, 76-98, 113-134, 155-177, 197-219, 231-253, 257-279, 292-311, 326-348, 373-395, 415-437, 457-479 and 499-521
316401011629	Signal peptide predicted for ETEC2914 by SignalP 2.0 HMM (Signal peptide probability 0.939) with cleavage site probability 0.716 between residues 31 and 32
316401011630	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
316401011631	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401011632	PS00190 Cytochrome c family heme-binding site signature.
316401011633	formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198
316401011634	Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671
316401011635	hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681
316401011636	PS00213 Lipocalin signature.
316401011637	PS01249 Hydrogenases expression/synthesis hypA family signature.
316401011638	hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463
316401011639	hydrogenase assembly chaperone; Provisional; Region: PRK10409
316401011640	PS01097 Hydrogenases expression/synthesis hupF/hypC family signature.
316401011641	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
316401011642	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
316401011643	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
316401011644	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
316401011645	dimerization interface [polypeptide binding]; other site
316401011646	ATP binding site [chemical binding]; other site
316401011647	formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429
316401011648	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
316401011649	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
316401011650	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316401011651	Walker A motif; other site
316401011652	ATP binding site [chemical binding]; other site
316401011653	Walker B motif; other site
316401011654	arginine finger; other site
316401011655	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
316401011656	PS00675 Sigma-54 interaction domain ATP-binding region A signature.
316401011657	PS00688 Sigma-54 interaction domain C-terminal part signature.
316401011658	Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756
316401011659	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
316401011660	MutS domain I; Region: MutS_I; pfam01624
316401011661	MutS domain II; Region: MutS_II; pfam05188
316401011662	MutS domain III; Region: MutS_III; pfam05192
316401011663	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
316401011664	Walker A/P-loop; other site
316401011665	ATP binding site [chemical binding]; other site
316401011666	Q-loop/lid; other site
316401011667	ABC transporter signature motif; other site
316401011668	Walker B; other site
316401011669	D-loop; other site
316401011670	H-loop/switch region; other site
316401011671	PS00030 Eukaryotic putative RNA-binding region RNP-1 signature.
316401011672	PS00017 ATP/GTP-binding site motif A (P-loop).
316401011673	PS00486 DNA mismatch repair proteins mutS family signature.
316401011674	PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424
316401011675	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
316401011676	active site
316401011677	metal binding site [ion binding]; metal-binding site
316401011678	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
316401011679	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
316401011680	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
316401011681	PS00894 Bacterial regulatory proteins, deoR family signature.
316401011682	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
316401011683	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
316401011684	Signal peptide predicted for ETEC2927 by SignalP 2.0 HMM (Signal peptide probability 0.623) with cleavage site probability 0.367 between residues 24 and 25
316401011685	PS00895 3-hydroxyisobutyrate dehydrogenase signature.
316401011686	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401011687	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
316401011688	putative aldolase; Validated; Region: PRK08130
316401011689	active site
316401011690	intersubunit interface [polypeptide binding]; other site
316401011691	Zn2+ binding site [ion binding]; other site
316401011692	hypothetical protein; Provisional; Region: PRK09989
316401011693	putative transporter; Provisional; Region: PRK09821
316401011694	GntP family permease; Region: GntP_permease; pfam02447
316401011695	Signal peptide predicted for ETEC2931 by SignalP 2.0 HMM (Signal peptide probability 0.974) with cleavage site probability 0.708 between residues 24 and 25
316401011696	11 probable transmembrane helices predicted for ETEC2931 by TMHMM2.0 at aa 4-22, 29-48, 53-75, 107-129, 175-197, 236-258, 273-294, 306-328, 343-362, 383-405 and 431-453
316401011697	RNA polymerase sigma factor RpoS; Validated; Region: PRK05657
316401011698	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
316401011699	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
316401011700	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
316401011701	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
316401011702	DNA binding residues [nucleotide binding]
316401011703	PS00716 Sigma-70 factors family signature 2.
316401011704	PS00715 Sigma-70 factors family signature 1.
316401011705	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
316401011706	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
316401011707	Peptidase family M23; Region: Peptidase_M23; pfam01551
316401011708	Signal peptide predicted for ETEC2933 by SignalP 2.0 HMM (Signal peptide probability 0.791) with cleavage site probability 0.527 between residues 29 and 30
316401011709	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
316401011710	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316401011711	S-adenosylmethionine binding site [chemical binding]; other site
316401011712	PS01279 Protein-L-isoaspartate(D-aspartate) O-methyltransferase signature.
316401011713	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
316401011714	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
316401011715	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
316401011716	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
316401011717	Permutation of conserved domain; other site
316401011718	active site
316401011719	PS01268 Uncharacterized protein family UPF0024 signature.
316401011720	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
316401011721	homotrimer interaction site [polypeptide binding]; other site
316401011722	zinc binding site [ion binding]; other site
316401011723	CDP-binding sites; other site
316401011724	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
316401011725	substrate binding site; other site
316401011726	dimer interface; other site
316401011727	PS01295 Uncharacterized protein family UPF0007 signature.
316401011728	cell division protein FtsB; Reviewed; Region: ftsB; PRK00888
316401011729	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
316401011730	1 probable transmembrane helix predicted for ETEC2939 by TMHMM2.0 at aa 4-21
316401011731	Protein of unknown function (DUF3561); Region: DUF3561; pfam12084
316401011732	3 probable transmembrane helices predicted for ETEC2940 by TMHMM2.0 at aa 21-43, 53-75 and 87-106
316401011733	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
316401011734	ligand-binding site [chemical binding]; other site
316401011735	PS00017 ATP/GTP-binding site motif A (P-loop).
316401011736	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
316401011737	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
316401011738	CysD dimerization site [polypeptide binding]; other site
316401011739	G1 box; other site
316401011740	putative GEF interaction site [polypeptide binding]; other site
316401011741	GTP/Mg2+ binding site [chemical binding]; other site
316401011742	Switch I region; other site
316401011743	G2 box; other site
316401011744	G3 box; other site
316401011745	Switch II region; other site
316401011746	G4 box; other site
316401011747	G5 box; other site
316401011748	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
316401011749	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
316401011750	PS00301 GTP-binding elongation factors signature.
316401011751	PS00017 ATP/GTP-binding site motif A (P-loop).
316401011752	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
316401011753	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
316401011754	Active Sites [active]
316401011755	PS00215 Mitochondrial energy transfer proteins signature.
316401011756	alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199
316401011757	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
316401011758	metal binding site [ion binding]; metal-binding site
316401011759	Signal peptide predicted for ETEC2944 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 24 and 25
316401011760	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648
316401011761	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719
316401011762	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09664
316401011763	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
316401011764	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645
316401011765	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646
316401011766	CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09670
316401011767	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669
316401011768	PS00225 Crystallins beta and gamma 'Greek key' motif signature.
316401011769	This CDS has been interrupted by a complex insertion
316401011770	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
316401011771	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
316401011772	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
316401011773	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
316401011774	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
316401011775	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
316401011776	Transposase; Region: HTH_Tnp_1; pfam01527
316401011777	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
316401011778	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
316401011779	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
316401011780	Active Sites [active]
316401011781	sulfite reductase subunit beta; Provisional; Region: PRK13504
316401011782	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
316401011783	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
316401011784	PS00365 Nitrite and sulfite reductases iron-sulfur/siroheme-binding site.
316401011785	sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953
316401011786	Flavodoxin; Region: Flavodoxin_1; pfam00258
316401011787	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
316401011788	FAD binding pocket [chemical binding]; other site
316401011789	FAD binding motif [chemical binding]; other site
316401011790	catalytic residues [active]
316401011791	NAD binding pocket [chemical binding]; other site
316401011792	phosphate binding motif [ion binding]; other site
316401011793	beta-alpha-beta structure motif; other site
316401011794	6-pyruvoyl tetrahydropterin synthase (PTPS). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a...; Region: PTPS; cd00470
316401011795	homohexamer interface [polypeptide binding]; other site
316401011796	putative substrate stabilizing pore; other site
316401011797	pterin binding site; other site
316401011798	putative oxidoreductase FixC; Provisional; Region: PRK10157
316401011799	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401011800	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
316401011801	Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954
316401011802	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
316401011803	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
316401011804	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
316401011805	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
316401011806	Ligand binding site [chemical binding]; other site
316401011807	Electron transfer flavoprotein domain; Region: ETF; pfam01012
316401011808	Protein of unknown function (DUF2950); Region: DUF2950; pfam11453
316401011809	benzoate transport; Region: 2A0115; TIGR00895
316401011810	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401011811	putative substrate translocation pore; other site
316401011812	12 probable transmembrane helices predicted for ETEC2964 by TMHMM2.0 at aa 20-42, 52-74, 86-105, 110-132, 144-163, 173-195, 251-273, 283-305, 312-331, 336-358, 370-392 and 397-419
316401011813	PS00217 Sugar transport proteins signature 2.
316401011814	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
316401011815	FAD binding domain; Region: FAD_binding_4; pfam01565
316401011816	2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935
316401011817	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
316401011818	NADP binding site [chemical binding]; other site
316401011819	homodimer interface [polypeptide binding]; other site
316401011820	active site
316401011821	PS00061 Short-chain dehydrogenases/reductases family signature.
316401011822	Major Facilitator Superfamily; Region: MFS_1; pfam07690
316401011823	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401011824	12 probable transmembrane helices predicted for ETEC2967 by TMHMM2.0 at aa 13-32, 47-69, 78-95, 99-121, 142-159, 174-193, 220-242, 257-279, 292-309, 319-341, 353-375 and 390-409
316401011825	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
316401011826	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
316401011827	nucleotide binding site [chemical binding]; other site
316401011829	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
316401011830	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
316401011831	enolase; Provisional; Region: eno; PRK00077
316401011832	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
316401011833	dimer interface [polypeptide binding]; other site
316401011834	metal binding site [ion binding]; metal-binding site
316401011835	substrate binding pocket [chemical binding]; other site
316401011836	PS00164 Enolase signature.
316401011837	CTP synthetase; Validated; Region: pyrG; PRK05380
316401011838	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
316401011839	Catalytic site [active]
316401011840	active site
316401011841	UTP binding site [chemical binding]; other site
316401011842	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
316401011843	active site
316401011844	putative oxyanion hole; other site
316401011845	catalytic triad [active]
316401011846	PS00442 Glutamine amidotransferases class-I active site.
316401011847	1 probable transmembrane helix predicted for ETEC2972 by TMHMM2.0 at aa 7-29
316401011848	Signal peptide predicted for ETEC2972 by SignalP 2.0 HMM (Signal peptide probability 0.616) with cleavage site probability 0.525 between residues 26 and 27
316401011849	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
316401011850	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
316401011851	homodimer interface [polypeptide binding]; other site
316401011852	metal binding site [ion binding]; metal-binding site
316401011853	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
316401011854	homodimer interface [polypeptide binding]; other site
316401011855	active site
316401011856	putative chemical substrate binding site [chemical binding]; other site
316401011857	metal binding site [ion binding]; metal-binding site
316401011858	toxin MazF; Provisional; Region: PRK09907
316401011859	antitoxin MazE; Provisional; Region: PRK09798
316401011860	(p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872
316401011861	HD domain; Region: HD_4; pfam13328
316401011862	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
316401011863	synthetase active site [active]
316401011864	NTP binding site [chemical binding]; other site
316401011865	metal binding site [ion binding]; metal-binding site
316401011866	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
316401011867	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
316401011868	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
316401011869	TRAM domain; Region: TRAM; pfam01938
316401011870	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316401011871	S-adenosylmethionine binding site [chemical binding]; other site
316401011872	PS01231 RNA methyltransferase trmA family signature 2.
316401011873	PS01230 RNA methyltransferase trmA family signature 1.
316401011874	hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107
316401011875	Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984
316401011876	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
316401011877	dimerization interface [polypeptide binding]; other site
316401011878	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316401011879	dimer interface [polypeptide binding]; other site
316401011880	phosphorylation site [posttranslational modification]
316401011881	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316401011882	ATP binding site [chemical binding]; other site
316401011883	Mg2+ binding site [ion binding]; other site
316401011884	G-X-G motif; other site
316401011885	Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999
316401011886	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316401011887	active site
316401011888	phosphorylation site [posttranslational modification]
316401011889	intermolecular recognition site; other site
316401011890	dimerization interface [polypeptide binding]; other site
316401011891	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
316401011892	putative binding surface; other site
316401011893	active site
316401011894	2 probable transmembrane helices predicted for ETEC2976 by TMHMM2.0 at aa 10-32 and 177-199
316401011895	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
316401011896	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
316401011897	active site
316401011898	tetramer interface [polypeptide binding]; other site
316401011899	PS00294 Prenyl group binding site (CAAX box).
316401011900	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
316401011901	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
316401011902	active site
316401011903	tetramer interface [polypeptide binding]; other site
316401011904	PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1.
316401011905	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401011906	D-galactonate transporter; Region: 2A0114; TIGR00893
316401011907	putative substrate translocation pore; other site
316401011908	12 probable transmembrane helices predicted for ETEC2979 by TMHMM2.0 at aa 20-42, 57-79, 86-105, 110-132, 152-174, 179-201, 256-278, 293-315, 328-348, 352-374, 387-409 and 414-436
316401011909	flavodoxin; Provisional; Region: PRK08105
316401011910	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
316401011911	tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563
316401011912	probable active site [active]
316401011913	PS01129 Rlu family of pseudouridine synthase signature.
316401011914	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098
316401011915	SecY interacting protein Syd; Provisional; Region: PRK04968
316401011916	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
316401011917	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
316401011918	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
316401011919	PS00017 ATP/GTP-binding site motif A (P-loop).
316401011920	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
316401011921	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
316401011922	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
316401011923	serine transporter; Region: stp; TIGR00814
316401011924	11 probable transmembrane helices predicted for ETEC2986 by TMHMM2.0 at aa 24-41, 45-67, 103-125, 140-157, 164-186, 206-228, 249-271, 300-322, 351-373, 377-394 and 406-428
316401011925	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
316401011926	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
316401011927	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
316401011928	flap endonuclease-like protein; Provisional; Region: PRK09482
316401011929	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
316401011930	active site
316401011931	metal binding site 1 [ion binding]; metal-binding site
316401011932	putative 5' ssDNA interaction site; other site
316401011933	metal binding site 3; metal-binding site
316401011934	metal binding site 2 [ion binding]; metal-binding site
316401011935	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
316401011936	putative DNA binding site [nucleotide binding]; other site
316401011937	putative metal binding site [ion binding]; other site
316401011938	L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624
316401011939	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
316401011940	dimer interface [polypeptide binding]; other site
316401011941	active site
316401011942	metal binding site [ion binding]; metal-binding site
316401011943	PS00060 Iron-containing alcohol dehydrogenases signature 2.
316401011944	PS00913 Iron-containing alcohol dehydrogenases signature 1.
316401011945	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
316401011946	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
316401011947	intersubunit interface [polypeptide binding]; other site
316401011948	active site
316401011949	Zn2+ binding site [ion binding]; other site
316401011950	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
316401011951	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401011952	putative substrate translocation pore; other site
316401011953	12 probable transmembrane helices predicted for ETEC2991 by TMHMM2.0 at aa 21-41, 61-83, 88-110, 120-142, 155-177, 212-234, 260-282, 292-314, 327-346, 351-373, 382-404 and 414-431
316401011954	L-fucose isomerase; Provisional; Region: fucI; PRK10991
316401011955	L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556
316401011956	hexamer (dimer of trimers) interface [polypeptide binding]; other site
316401011957	trimer interface [polypeptide binding]; other site
316401011958	substrate binding site [chemical binding]; other site
316401011959	Mn binding site [ion binding]; other site
316401011960	L-fuculokinase; Provisional; Region: PRK10331
316401011961	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
316401011962	nucleotide binding site [chemical binding]; other site
316401011963	PS00933 FGGY family of carbohydrate kinases signature 1.
316401011964	PS00445 FGGY family of carbohydrate kinases signature 2.
316401011965	L-fucose mutarotase; Provisional; Region: fucU; PRK15420
316401011966	DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411
316401011967	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
316401011968	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
316401011969	PS00894 Bacterial regulatory proteins, deoR family signature.
316401011970	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
316401011971	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
316401011972	hypothetical protein; Provisional; Region: PRK10873
316401011973	4 probable transmembrane helices predicted for ETEC2997 by TMHMM2.0 at aa 5-27, 37-59, 66-88 and 98-120
316401011974	Signal peptide predicted for ETEC2997 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.582 between residues 24 and 25
316401011975	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
316401011976	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401011977	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
316401011978	dimerization interface [polypeptide binding]; other site
316401011979	substrate binding pocket [chemical binding]; other site
316401011980	PS00044 Bacterial regulatory proteins, lysR family signature.
316401011981	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
316401011982	1 probable transmembrane helix predicted for ETEC2999 by TMHMM2.0 at aa 4-26
316401011983	Signal peptide predicted for ETEC2999 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.623 between residues 21 and 22
316401011984	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401011985	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
316401011986	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
316401011987	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
316401011988	catalytic residue [active]
316401011989	PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site.
316401011990	CsdA-binding activator; Provisional; Region: PRK15019
316401011991	sulfur acceptor protein CsdL; Provisional; Region: PRK15116
316401011992	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
316401011993	putative ATP binding site [chemical binding]; other site
316401011994	putative substrate interface [chemical binding]; other site
316401011995	1 probable transmembrane helix predicted for ETEC3002 by TMHMM2.0 at aa 235-257
316401011996	murein transglycosylase A; Provisional; Region: mltA; PRK11162
316401011997	MltA specific insert domain; Region: MltA; pfam03562
316401011998	3D domain; Region: 3D; pfam06725
316401011999	Signal peptide predicted for ETEC3003 by SignalP 2.0 HMM (Signal peptide probability 0.916) with cleavage site probability 0.584 between residues 23 and 24
316401012000	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401012001	AMIN domain; Region: AMIN; pfam11741
316401012002	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
316401012003	active site
316401012004	metal binding site [ion binding]; metal-binding site
316401012005	Signal peptide predicted for ETEC3004 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.988 between residues 31 and 32
316401012006	N-acetylglutamate synthase; Validated; Region: PRK05279
316401012007	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
316401012008	putative feedback inhibition sensing region; other site
316401012009	putative nucleotide binding site [chemical binding]; other site
316401012010	putative substrate binding site [chemical binding]; other site
316401012011	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
316401012012	Coenzyme A binding pocket [chemical binding]; other site
316401012013	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
316401012014	AAA domain; Region: AAA_30; pfam13604
316401012015	Family description; Region: UvrD_C_2; pfam13538
316401012016	PS00017 ATP/GTP-binding site motif A (P-loop).
316401012017	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
316401012018	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
316401012019	PS00017 ATP/GTP-binding site motif A (P-loop).
316401012020	protease3; Provisional; Region: PRK15101
316401012021	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
316401012022	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
316401012023	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
316401012024	PS00143 Insulinase family, zinc-binding region signature.
316401012025	Signal peptide predicted for ETEC3008 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 23 and 24
316401012026	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
316401012027	exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450
316401012028	hypothetical protein; Provisional; Region: PRK10332
316401012029	Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528
316401012030	1 probable transmembrane helix predicted for ETEC3010 by TMHMM2.0 at aa 15-37
316401012031	PS00409 Prokaryotic N-terminal methylation site.
316401012032	hypothetical protein; Provisional; Region: PRK11521
316401012033	1 probable transmembrane helix predicted for ETEC3011 by TMHMM2.0 at aa 7-29
316401012034	Signal peptide predicted for ETEC3011 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.893 between residues 26 and 27
316401012035	hypothetical protein; Provisional; Region: PRK10557
316401012036	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
316401012037	1 probable transmembrane helix predicted for ETEC3012 by TMHMM2.0 at aa 7-29
316401012038	PS00409 Prokaryotic N-terminal methylation site.
316401012039	hypothetical protein; Provisional; Region: PRK10506
316401012040	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
316401012041	Signal peptide predicted for ETEC3013 by SignalP 2.0 HMM (Signal peptide probability 0.963) with cleavage site probability 0.888 between residues 29 and 30
316401012042	1 probable transmembrane helix predicted for ETEC3013 by TMHMM2.0 at aa 7-29
316401012043	PS00409 Prokaryotic N-terminal methylation site.
316401012044	thymidylate synthase; Reviewed; Region: thyA; PRK01827
316401012045	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
316401012046	dimerization interface [polypeptide binding]; other site
316401012047	active site
316401012048	PS00091 Thymidylate synthase active site.
316401012049	prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544
316401012050	5 probable transmembrane helices predicted for ETEC3015 by TMHMM2.0 at aa 15-37, 58-80, 95-117, 223-245 and 260-282
316401012051	PS01311 Prolipoprotein diacylglyceryl transferase signature.
316401012052	fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061
316401012053	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
316401012054	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
316401012055	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
316401012056	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
316401012057	PS00742 PEP-utilizing enzymes signature 2.
316401012058	PS00370 PEP-utilizing enzymes phosphorylation site signature.
316401012059	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
316401012060	putative active site [active]
316401012061	Ap4A binding site [chemical binding]; other site
316401012062	nudix motif; other site
316401012063	putative metal binding site [ion binding]; other site
316401012064	PS00893 mutT domain signature.
316401012065	MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex.   MutH...; Region: MutH_Sau3AI; cd00583
316401012066	putative DNA-binding cleft [nucleotide binding]; other site
316401012067	putative DNA clevage site; other site
316401012068	molecular lever; other site
316401012069	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
316401012070	7 probable transmembrane helices predicted for ETEC3019 by TMHMM2.0 at aa 15-37, 50-69, 79-101, 122-139, 154-176, 183-202 and 212-230
316401012071	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
316401012072	Signal peptide predicted for ETEC3020 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.673 between residues 19 and 20
316401012073	1 probable transmembrane helix predicted for ETEC3020 by TMHMM2.0 at aa 4-26
316401012074	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401012075	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
316401012076	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
316401012077	active site
316401012078	catalytic tetrad [active]
316401012079	lysophospholipid transporter LplT; Provisional; Region: PRK11195
316401012080	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401012081	10 probable transmembrane helices predicted for ETEC3022 by TMHMM2.0 at aa 19-41, 51-73, 94-116, 162-184, 220-242, 257-279, 286-303, 308-330, 343-365 and 370-392
316401012082	bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043
316401012083	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
316401012084	putative acyl-acceptor binding pocket; other site
316401012085	C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909
316401012086	acyl-activating enzyme (AAE) consensus motif; other site
316401012087	putative AMP binding site [chemical binding]; other site
316401012088	PS00455 Putative AMP-binding domain signature.
316401012089	DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727
316401012090	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
316401012091	DNA binding site [nucleotide binding]
316401012092	domain linker motif; other site
316401012093	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
316401012094	dimerization interface (closed form) [polypeptide binding]; other site
316401012095	ligand binding site [chemical binding]; other site
316401012096	PS00356 Bacterial regulatory proteins, lacI family signature.
316401012097	diaminopimelate decarboxylase; Provisional; Region: PRK11165
316401012098	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
316401012099	active site
316401012100	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
316401012101	substrate binding site [chemical binding]; other site
316401012102	catalytic residues [active]
316401012103	dimer interface [polypeptide binding]; other site
316401012104	PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2.
316401012105	PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site.
316401012106	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
316401012107	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401012108	The C-terminal substrate binding domain of LysR, transcriptional regulator for lysine biosynthesis, contains the type 2 periplasmic binding fold; Region: PBP2_LysR; cd08456
316401012109	putative dimerization interface [polypeptide binding]; other site
316401012110	PS00044 Bacterial regulatory proteins, lysR family signature.
316401012111	putative racemase; Provisional; Region: PRK10200
316401012112	aspartate racemase; Region: asp_race; TIGR00035
316401012113	PS00924 Aspartate and glutamate racemases signature 2.
316401012114	PS00923 Aspartate and glutamate racemases signature 1.
316401012115	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
316401012116	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401012117	putative substrate translocation pore; other site
316401012118	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401012119	12 probable transmembrane helices predicted for ETEC3028 by TMHMM2.0 at aa 21-43, 63-83, 90-112, 116-138, 150-167, 177-199, 259-281, 296-318, 325-347, 362-384, 397-419 and 424-446
316401012120	PS00216 Sugar transport proteins signature 1.
316401012121	PS00217 Sugar transport proteins signature 2.
316401012122	2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993
316401012123	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
316401012124	NADP binding site [chemical binding]; other site
316401012125	homodimer interface [polypeptide binding]; other site
316401012126	active site
316401012127	PS00061 Short-chain dehydrogenases/reductases family signature.
316401012128	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
316401012129	putative acyltransferase; Provisional; Region: PRK05790
316401012130	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
316401012131	dimer interface [polypeptide binding]; other site
316401012132	active site
316401012133	PS00099 Thiolases active site.
316401012134	PS00737 Thiolases signature 2.
316401012135	PS00098 Thiolases acyl-enzyme intermediate signature.
316401012136	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
316401012137	serine transporter; Region: stp; TIGR00814
316401012138	10 probable transmembrane helices predicted for ETEC3032 by TMHMM2.0 at aa 20-42, 86-108, 123-145, 152-174, 194-216, 236-258, 287-309, 334-356, 360-382 and 389-408
316401012139	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
316401012140	DNA binding residues [nucleotide binding]
316401012141	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
316401012142	1 probable transmembrane helix predicted for ETEC3034 by TMHMM2.0 at aa 152-174
316401012143	Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871
316401012144	Signal peptide predicted for ETEC3035 by SignalP 2.0 HMM (Signal peptide probability 0.983) with cleavage site probability 0.786 between residues 27 and 28
316401012145	1 probable transmembrane helix predicted for ETEC3035 by TMHMM2.0 at aa 7-26
316401012146	type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552
316401012147	Tetratricopeptide repeat; Region: TPR_3; pfam07720
316401012148	Tetratricopeptide repeat; Region: TPR_3; pfam07720
316401012149	transcriptional regulator; Provisional; Region: PRK11906
316401012150	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
316401012151	DNA binding site [nucleotide binding]
316401012152	Tetratricopeptide repeat; Region: TPR_2; pfam07719
316401012153	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
316401012154	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
316401012155	N-acetyl-D-glucosamine binding site [chemical binding]; other site
316401012156	catalytic residue [active]
316401012157	Signal peptide predicted for ETEC3041 by SignalP 2.0 HMM (Signal peptide probability 0.907) with cleavage site probability 0.443 between residues 24 and 25
316401012158	Similar to Escherichia coli. ygek UniProt:Q46791 (EMBL:U28375 (210 aa) fasta scores: E()=4.2e-59, 97.619% id in 168 aa. Stop codon at codon 52
316401012159	invasion protein OrgB; Provisional; Region: PRK15322
316401012160	Bacterial type III secretion apparatus protein (OrgA_MxiK); Region: OrgA_MxiK; pfam09482
316401012161	Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669
316401012162	1 probable transmembrane helix predicted for ETEC3045 by TMHMM2.0 at aa 210-229
316401012163	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401012164	type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325
316401012165	Type III secretion needle MxiH like; Region: MxiH; cl09641
316401012166	type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327; cl12363
316401012167	Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480
316401012168	1 probable transmembrane helix predicted for ETEC3048 by TMHMM2.0 at aa 148-170
316401012169	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
316401012170	DNA binding residues [nucleotide binding]
316401012171	dimerization interface [polypeptide binding]; other site
316401012172	InvH outer membrane lipoprotein; Region: InvH; pfam04741
316401012173	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401012174	type III secretion system protein SpaS; Validated; Region: PRK08156
316401012175	type III secretion system protein SpaS; Validated; Region: PRK08156
316401012176	4 probable transmembrane helices predicted for ETEC3052 by TMHMM2.0 at aa 28-50, 76-98, 134-153 and 177-199
316401012177	type III secretion protein SpaR/YscT/HrcT; Region: fliR_like_III; TIGR01401
316401012178	4 probable transmembrane helices predicted for ETEC3053 by TMHMM2.0 at aa 12-34, 78-100, 181-203 and 213-235
316401012179	type III secretion system protein SpaQ; Provisional; Region: PRK15333
316401012180	2 probable transmembrane helices predicted for ETEC3054 by TMHMM2.0 at aa 12-34 and 49-68
316401012181	type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796
316401012182	4 probable transmembrane helices predicted for ETEC3055 by TMHMM2.0 at aa 15-37, 50-67, 154-176 and 183-205
316401012183	PS01061 Flagella transport protein fliP family signature 2.
316401012184	Signal peptide predicted for ETEC3055 by SignalP 2.0 HMM (Signal peptide probability 0.931) with cleavage site probability 0.543 between residues 22 and 23
316401012185	type III secretion system protein SpaO; Validated; Region: PRK08158
316401012186	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
316401012187	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
316401012188	Signal peptide predicted for ETEC3058 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.533 between residues 24 and 25
316401012189	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401012190	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
316401012191	Peptidase family M23; Region: Peptidase_M23; pfam01551
316401012192	Signal peptide predicted for ETEC3059 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.809 between residues 31 and 32
316401012193	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401012194	xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970
316401012195	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315
316401012196	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
316401012197	xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971
316401012198	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
316401012199	xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908
316401012200	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
316401012201	catalytic loop [active]
316401012202	iron binding site [ion binding]; other site
316401012203	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
316401012204	GAF domain; Region: GAF; cl17456
316401012205	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
316401012206	PAS domain; Region: PAS; smart00091
316401012207	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316401012208	Walker A motif; other site
316401012209	ATP binding site [chemical binding]; other site
316401012210	Walker B motif; other site
316401012211	arginine finger; other site
316401012212	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
316401012213	PS00688 Sigma-54 interaction domain C-terminal part signature.
316401012214	PS00017 ATP/GTP-binding site motif A (P-loop).
316401012215	PS00675 Sigma-54 interaction domain ATP-binding region A signature.
316401012216	aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200
316401012217	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
316401012218	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
316401012219	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
316401012220	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640
316401012221	catalytic residue [active]
316401012222	peptidase; Reviewed; Region: PRK13004
316401012223	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649
316401012224	putative metal binding site [ion binding]; other site
316401012225	putative dimer interface [polypeptide binding]; other site
316401012226	PS00148 Arginase family signature 2.
316401012227	PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1.
316401012228	PS00639 Eukaryotic thiol (cysteine) proteases histidine active site.
316401012229	D-hydantoinase; Region: D-hydantoinase; TIGR02033
316401012230	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
316401012231	tetramer interface [polypeptide binding]; other site
316401012232	active site
316401012233	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
316401012234	carbamate kinase; Reviewed; Region: PRK12686
316401012235	putative substrate binding site [chemical binding]; other site
316401012236	homodimer interface [polypeptide binding]; other site
316401012237	nucleotide binding site [chemical binding]; other site
316401012238	nucleotide binding site [chemical binding]; other site
316401012239	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
316401012240	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
316401012241	XdhC Rossmann domain; Region: XdhC_C; pfam13478
316401012242	selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309
316401012243	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
316401012244	probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172
316401012245	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
316401012246	Ligand binding site; other site
316401012247	metal-binding site
316401012248	putative selenate reductase subunit YgfK; Provisional; Region: PRK09853
316401012249	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
316401012250	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
316401012251	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
316401012252	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401012253	putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314
316401012254	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
316401012255	active site
316401012256	putative substrate binding pocket [chemical binding]; other site
316401012257	PS00626 Regulator of chromosome condensation (RCC1) signature 2.
316401012258	probable selenate reductase, FAD-binding subunit; Region: Se_sel_red_FAD; TIGR03312
316401012259	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
316401012260	putative hypoxanthine oxidase; Provisional; Region: PRK09800
316401012261	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
316401012262	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315
316401012263	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
316401012264	uracil-xanthine permease; Region: ncs2; TIGR00801
316401012265	12 probable transmembrane helices predicted for ETEC3076 by TMHMM2.0 at aa 24-46, 56-74, 79-101, 116-138, 150-172, 187-204, 211-233, 253-275, 301-323, 338-360, 367-389 and 424-446
316401012266	PS01116 Xanthine/uracil permeases family signature.
316401012267	guanine deaminase; Provisional; Region: PRK09228
316401012268	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
316401012269	active site
316401012270	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
316401012271	12 probable transmembrane helices predicted for ETEC3078 by TMHMM2.0 at aa 35-57, 62-84, 91-113, 118-140, 147-169, 179-201, 208-230, 250-272, 341-363, 367-384, 397-419 and 434-453
316401012272	PS00017 ATP/GTP-binding site motif A (P-loop).
316401012273	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
316401012274	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401012275	putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12809
316401012276	4Fe-4S binding domain; Region: Fer4; pfam00037
316401012277	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
316401012278	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401012279	PS00190 Cytochrome c family heme-binding site signature.
316401012280	xanthine permease; Region: pbuX; TIGR03173
316401012281	12 probable transmembrane helices predicted for ETEC3081 by TMHMM2.0 at aa 30-52, 62-84, 89-111, 116-138, 145-167, 182-199, 204-226, 257-279, 333-355, 360-382, 391-408 and 423-445
316401012282	PS01116 Xanthine/uracil permeases family signature.
316401012283	Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443
316401012284	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
316401012285	active site
316401012286	metal binding site [ion binding]; metal-binding site
316401012287	nudix motif; other site
316401012288	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
316401012289	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
316401012290	dimer interface [polypeptide binding]; other site
316401012291	putative anticodon binding site; other site
316401012292	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
316401012293	motif 1; other site
316401012294	active site
316401012295	motif 2; other site
316401012296	motif 3; other site
316401012297	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
316401012298	PS00017 ATP/GTP-binding site motif A (P-loop).
316401012299	PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1.
316401012300	peptide chain release factor 2; Validated; Region: prfB; PRK00578
316401012301	This domain is found in peptide chain release factors; Region: PCRF; smart00937
316401012302	RF-1 domain; Region: RF-1; pfam00472
316401012303	PS00745 Prokaryotic-type class I peptide chain release factors signature.
316401012304	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
316401012305	DHH family; Region: DHH; pfam01368
316401012306	DHHA1 domain; Region: DHHA1; pfam02272
316401012307	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
316401012308	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
316401012309	dimerization domain [polypeptide binding]; other site
316401012310	dimer interface [polypeptide binding]; other site
316401012311	catalytic residues [active]
316401012312	PS00194 Thioredoxin family active site.
316401012313	PS00190 Cytochrome c family heme-binding site signature.
316401012314	Signal peptide predicted for ETEC3086 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 20 and 21
316401012315	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
316401012316	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
316401012317	active site
316401012318	Int/Topo IB signature motif; other site
316401012319	flavodoxin FldB; Provisional; Region: PRK12359
316401012320	PS00201 Flavodoxin signature.
316401012321	Protein of unknown function (DUF1434); Region: DUF1434; pfam07254
316401012322	1 probable transmembrane helix predicted for ETEC3089 by TMHMM2.0 at aa 20-51
316401012323	hypothetical protein; Provisional; Region: PRK10878
316401012324	putative global regulator; Reviewed; Region: PRK09559
316401012325	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
316401012326	hemolysin; Provisional; Region: PRK15087
316401012327	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
316401012328	7 probable transmembrane helices predicted for ETEC3092 by TMHMM2.0 at aa 20-42, 46-68, 89-107, 112-134, 139-161, 165-187 and 194-216
316401012329	ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552
316401012330	6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014
316401012331	beta-galactosidase; Region: BGL; TIGR03356
316401012332	PS00653 Glycosyl hydrolases family 1 N-terminal signature.
316401012333	PS00572 Glycosyl hydrolases family 1 active site.
316401012334	putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730
316401012335	classical (c) SDRs; Region: SDR_c; cd05233
316401012336	NAD(P) binding site [chemical binding]; other site
316401012337	active site
316401012338	PS00061 Short-chain dehydrogenases/reductases family signature.
316401012339	glycine dehydrogenase; Provisional; Region: PRK05367
316401012340	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
316401012341	tetramer interface [polypeptide binding]; other site
316401012342	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316401012343	catalytic residue [active]
316401012344	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
316401012345	tetramer interface [polypeptide binding]; other site
316401012346	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316401012347	catalytic residue [active]
316401012348	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
316401012349	lipoyl attachment site [posttranslational modification]; other site
316401012350	PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site.
316401012351	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
316401012352	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
316401012353	oxidoreductase; Provisional; Region: PRK08013
316401012354	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
316401012355	PS01304 ubiH/COQ6 monooxygenase family signature.
316401012356	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401012357	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732
316401012358	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
316401012359	PS01304 ubiH/COQ6 monooxygenase family signature.
316401012360	Signal peptide predicted for ETEC3100 by SignalP 2.0 HMM (Signal peptide probability 0.990) with cleavage site probability 0.974 between residues 25 and 26
316401012361	proline aminopeptidase P II; Provisional; Region: PRK10879
316401012362	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
316401012363	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
316401012364	active site
316401012365	PS00491 Aminopeptidase P and proline dipeptidase signature.
316401012366	hypothetical protein; Reviewed; Region: PRK01736
316401012367	Z-ring-associated protein; Provisional; Region: PRK10972
316401012368	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
316401012369	5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333
316401012370	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
316401012371	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
316401012372	ligand binding site [chemical binding]; other site
316401012373	NAD binding site [chemical binding]; other site
316401012374	tetramer interface [polypeptide binding]; other site
316401012375	catalytic site [active]
316401012376	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
316401012377	L-serine binding site [chemical binding]; other site
316401012378	ACT domain interface; other site
316401012379	PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3.
316401012380	PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2.
316401012381	PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature.
316401012382	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
316401012383	tetramer (dimer of dimers) interface [polypeptide binding]; other site
316401012384	active site
316401012385	dimer interface [polypeptide binding]; other site
316401012386	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
316401012387	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
316401012388	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401012389	The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428
316401012390	putative dimerization interface [polypeptide binding]; other site
316401012391	PS00044 Bacterial regulatory proteins, lysR family signature.
316401012392	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
316401012393	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
316401012394	active site
316401012395	substrate binding site [chemical binding]; other site
316401012396	coenzyme B12 binding site [chemical binding]; other site
316401012397	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
316401012398	B12 binding site [chemical binding]; other site
316401012399	cobalt ligand [ion binding]; other site
316401012400	PS00544 Methylmalonyl-CoA mutase signature.
316401012401	membrane ATPase/protein kinase; Provisional; Region: PRK09435
316401012402	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
316401012403	Walker A; other site
316401012404	PS00017 ATP/GTP-binding site motif A (P-loop).
316401012405	methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423
316401012406	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
316401012407	substrate binding site [chemical binding]; other site
316401012408	oxyanion hole (OAH) forming residues; other site
316401012409	trimer interface [polypeptide binding]; other site
316401012410	PS00166 Enoyl-CoA hydratase/isomerase signature.
316401012411	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
316401012412	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
316401012413	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
316401012414	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401012415	Transcriptional regulator [Transcription]; Region: LysR; COG0583
316401012416	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
316401012417	dimerization interface [polypeptide binding]; other site
316401012418	PS00044 Bacterial regulatory proteins, lysR family signature.
316401012419	Uncharacterized conserved protein [Function unknown]; Region: COG2968
316401012420	oxidative stress defense protein; Provisional; Region: PRK11087
316401012421	Signal peptide predicted for ETEC3114 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.989 between residues 21 and 22
316401012422	arginine exporter protein; Provisional; Region: PRK09304
316401012423	6 probable transmembrane helices predicted for ETEC3115 by TMHMM2.0 at aa 4-26, 39-61, 66-88, 111-133, 148-170 and 182-199
316401012424	Signal peptide predicted for ETEC3115 by SignalP 2.0 HMM (Signal peptide probability 0.942) with cleavage site probability 0.707 between residues 26 and 27
316401012425	mechanosensitive channel MscS; Provisional; Region: PRK10334
316401012426	Mechanosensitive ion channel; Region: MS_channel; pfam00924
316401012427	PS01246 Uncharacterized protein family UPF0003 signature.
316401012428	3 probable transmembrane helices predicted for ETEC3116 by TMHMM2.0 at aa 22-44, 65-87 and 102-124
316401012429	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
316401012430	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
316401012431	active site
316401012432	intersubunit interface [polypeptide binding]; other site
316401012433	zinc binding site [ion binding]; other site
316401012434	Na+ binding site [ion binding]; other site
316401012435	PS00806 Fructose-bisphosphate aldolase class-II signature 2.
316401012436	PS00602 Fructose-bisphosphate aldolase class-II signature 1.
316401012437	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
316401012438	Phosphoglycerate kinase; Region: PGK; pfam00162
316401012439	substrate binding site [chemical binding]; other site
316401012440	hinge regions; other site
316401012441	ADP binding site [chemical binding]; other site
316401012442	catalytic site [active]
316401012443	PS00111 Phosphoglycerate kinase signature.
316401012444	erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535
316401012445	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
316401012446	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
316401012447	PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site.
316401012448	Similar, with a frameshift mutation, to Escherichia coli B. hypothetical protein. UniProt:A2UCU6 (EMBL:AAWW01000001 (237 aa) fasta scores: E()=4.8e-54, 92.857% id in 252 aa
316401012449	Transcriptional regulator [Transcription]; Region: MtlR; COG3722
316401012450	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022
316401012451	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
316401012452	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
316401012453	putative active site [active]
316401012454	L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238
316401012455	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
316401012456	putative NAD(P) binding site [chemical binding]; other site
316401012457	catalytic Zn binding site [ion binding]; other site
316401012458	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
316401012459	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
316401012460	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
316401012461	active site
316401012462	P-loop; other site
316401012463	phosphorylation site [posttranslational modification]
316401012464	8 probable transmembrane helices predicted for ETEC3125 by TMHMM2.0 at aa 21-43, 53-75, 82-104, 136-158, 214-236, 246-264, 271-293 and 313-335
316401012465	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
316401012466	active site
316401012467	phosphorylation site [posttranslational modification]
316401012468	PS00372 PTS EIIA domains phosphorylation site signature 2.
316401012469	transketolase; Reviewed; Region: PRK12753
316401012470	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
316401012471	TPP-binding site [chemical binding]; other site
316401012472	dimer interface [polypeptide binding]; other site
316401012473	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
316401012474	PYR/PP interface [polypeptide binding]; other site
316401012475	dimer interface [polypeptide binding]; other site
316401012476	TPP binding site [chemical binding]; other site
316401012477	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
316401012478	PS00802 Transketolase signature 2.
316401012479	PS00801 Transketolase signature 1.
316401012480	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
316401012481	Signal peptide predicted for ETEC3128 by SignalP 2.0 HMM (Signal peptide probability 0.931) with cleavage site probability 0.549 between residues 21 and 22
316401012482	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401012483	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
316401012484	agmatinase; Region: agmatinase; TIGR01230
316401012485	oligomer interface [polypeptide binding]; other site
316401012486	putative active site [active]
316401012487	Mn binding site [ion binding]; other site
316401012488	PS01053 Arginase family signature 3.
316401012489	PS00148 Arginase family signature 2.
316401012490	PS00147 Arginase family signature 1.
316401012491	Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166
316401012492	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
316401012493	dimer interface [polypeptide binding]; other site
316401012494	active site
316401012495	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
316401012496	catalytic residues [active]
316401012497	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
316401012498	PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2.
316401012499	PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site.
316401012500	S-adenosylmethionine synthetase; Validated; Region: PRK05250
316401012501	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
316401012502	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
316401012503	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
316401012504	PS00376 S-adenosylmethionine synthetase signature 1.
316401012505	PS00377 S-adenosylmethionine synthetase signature 2.
316401012506	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
316401012507	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401012508	putative substrate translocation pore; other site
316401012509	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401012510	Signal peptide predicted for ETEC3133 by SignalP 2.0 HMM (Signal peptide probability 0.964) with cleavage site probability 0.872 between residues 30 and 31
316401012511	12 probable transmembrane helices predicted for ETEC3133 by TMHMM2.0 at aa 13-35, 55-77, 84-103, 108-130, 142-159, 169-191, 252-274, 289-311, 318-340, 350-372, 385-407 and 417-436
316401012512	PS00217 Sugar transport proteins signature 2.
316401012513	PS00216 Sugar transport proteins signature 1.
316401012514	hypothetical protein; Provisional; Region: PRK04860
316401012515	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
316401012516	PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.
316401012517	DNA-specific endonuclease I; Provisional; Region: PRK15137
316401012518	Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356
316401012519	Signal peptide predicted for ETEC3135 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 22 and 23
316401012520	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
316401012521	RNA methyltransferase, RsmE family; Region: TIGR00046
316401012522	PS00215 Mitochondrial energy transfer proteins signature.
316401012523	glutathione synthetase; Provisional; Region: PRK05246
316401012524	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
316401012525	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
316401012526	PS00030 Eukaryotic putative RNA-binding region RNP-1 signature.
316401012527	hypothetical protein; Validated; Region: PRK00228
316401012528	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
316401012529	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
316401012530	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
316401012531	Walker A motif; other site
316401012532	ATP binding site [chemical binding]; other site
316401012533	Walker B motif; other site
316401012534	PS00662 Bacterial type II secretion system protein E signature.
316401012535	PS00017 ATP/GTP-binding site motif A (P-loop).
316401012536	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
316401012537	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
316401012538	catalytic residue [active]
316401012539	PS01211 Uncharacterized protein family UPF0001 signature.
316401012540	YGGT family; Region: YGGT; pfam02325
316401012541	YGGT family; Region: YGGT; pfam02325
316401012542	4 probable transmembrane helices predicted for ETEC3142 by TMHMM2.0 at aa 5-27, 67-89, 96-118 and 144-166
316401012543	hypothetical protein; Validated; Region: PRK05090
316401012544	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
316401012545	active site
316401012546	dimerization interface [polypeptide binding]; other site
316401012547	HemN family oxidoreductase; Provisional; Region: PRK05660
316401012548	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316401012549	FeS/SAM binding site; other site
316401012550	HemN C-terminal domain; Region: HemN_C; pfam06969
316401012551	Protein of unknown function (DUF1202); Region: DUF1202; pfam06717
316401012552	Signal peptide predicted for ETEC3146 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 21 and 22
316401012553	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411
316401012554	homodimer interface [polypeptide binding]; other site
316401012555	active site
316401012556	PS00445 FGGY family of carbohydrate kinases signature 2.
316401012557	PS00917 Asparaginase / glutaminase active site signature 2.
316401012558	PS00144 Asparaginase / glutaminase active site signature 1.
316401012559	1 probable transmembrane helix predicted for ETEC3147 by TMHMM2.0 at aa 7-29
316401012560	Signal peptide predicted for ETEC3147 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 22 and 23
316401012561	hypothetical protein; Provisional; Region: PRK10626
316401012562	Protein of unknown function (DUF2884); Region: DUF2884; pfam11101
316401012563	Signal peptide predicted for ETEC3148 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.986 between residues 20 and 21
316401012564	hypothetical protein; Provisional; Region: PRK11702
316401012565	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
316401012566	adenine DNA glycosylase; Provisional; Region: PRK10880
316401012567	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
316401012568	minor groove reading motif; other site
316401012569	helix-hairpin-helix signature motif; other site
316401012570	substrate binding pocket [chemical binding]; other site
316401012571	active site
316401012572	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
316401012573	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
316401012574	DNA binding and oxoG recognition site [nucleotide binding]
316401012575	PS01155 Endonuclease III family signature.
316401012576	PS00764 Endonuclease III iron-sulfur binding region signature.
316401012577	oxidative damage protection protein; Provisional; Region: PRK05408
316401012578	murein transglycosylase C; Provisional; Region: mltC; PRK11671
316401012579	Domain of unknown function (DUF3393); Region: DUF3393; pfam11873
316401012580	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
316401012581	N-acetyl-D-glucosamine binding site [chemical binding]; other site
316401012582	catalytic residue [active]
316401012583	Signal peptide predicted for ETEC3153 by SignalP 2.0 HMM (Signal peptide probability 0.987) with cleavage site probability 0.383 between residues 22 and 23
316401012584	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401012585	PS00922 Prokaryotic transglycosylases signature.
316401012586	nucleoside transporter; Region: 2A0110; TIGR00889
316401012587	12 probable transmembrane helices predicted for ETEC3154 by TMHMM2.0 at aa 7-29, 39-61, 68-90, 94-116, 137-159, 163-185, 211-233, 253-275, 282-301, 311-333, 346-365 and 380-402
316401012588	ornithine decarboxylase; Provisional; Region: PRK13578
316401012589	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
316401012590	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
316401012591	homodimer interface [polypeptide binding]; other site
316401012592	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316401012593	catalytic residue [active]
316401012594	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
316401012595	PS00703 Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site.
316401012596	Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811
316401012597	6 probable transmembrane helices predicted for ETEC3156 by TMHMM2.0 at aa 4-23, 36-58, 102-124, 145-167, 177-199 and 211-233
316401012598	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
316401012599	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
316401012600	active site
316401012601	Int/Topo IB signature motif; other site
316401012602	PS00018 EF-hand calcium-binding domain.
316401012603	RNA polymerase sigma factor FecI; Provisional; Region: PRK09651
316401012604	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
316401012605	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
316401012606	DNA binding residues [nucleotide binding]
316401012607	PS01063 Sigma-70 factors ECF subfamily signature.
316401012608	fec operon regulator FecR; Reviewed; Region: PRK09774
316401012609	FecR protein; Region: FecR; pfam04773
316401012610	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
316401012611	Secretin and TonB N terminus short domain; Region: STN; smart00965
316401012612	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
316401012613	N-terminal plug; other site
316401012614	ligand-binding site [chemical binding]; other site
316401012615	Signal peptide predicted for ETEC3162 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 33 and 34
316401012616	PS01156 TonB-dependent receptor proteins signature 2.
316401012617	iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411
316401012618	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
316401012619	siderophore binding site; other site
316401012620	Signal peptide predicted for ETEC3163 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.985 between residues 21 and 22
316401012621	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
316401012622	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
316401012623	dimer interface [polypeptide binding]; other site
316401012624	ABC-ATPase subunit  interface; other site
316401012625	putative PBP binding regions; other site
316401012626	Signal peptide predicted for ETEC3164 by SignalP 2.0 HMM (Signal peptide probability 0.961) with cleavage site probability 0.600 between residues 36 and 37
316401012627	8 probable transmembrane helices predicted for ETEC3164 by TMHMM2.0 at aa 7-29, 59-81, 94-116, 121-143, 152-174, 198-220, 241-263 and 306-328
316401012628	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
316401012629	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
316401012630	ABC-ATPase subunit  interface; other site
316401012631	dimer interface [polypeptide binding]; other site
316401012632	putative PBP binding regions; other site
316401012633	7 probable transmembrane helices predicted for ETEC3165 by TMHMM2.0 at aa 4-26, 55-77, 108-130, 180-202, 226-248, 269-291 and 296-315
316401012634	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401012635	iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231
316401012636	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
316401012637	Walker A/P-loop; other site
316401012638	ATP binding site [chemical binding]; other site
316401012639	Q-loop/lid; other site
316401012640	ABC transporter signature motif; other site
316401012641	Walker B; other site
316401012642	D-loop; other site
316401012643	H-loop/switch region; other site
316401012644	PS00017 ATP/GTP-binding site motif A (P-loop).
316401012645	PS00211 ABC transporters family signature.
316401012646	PS00294 Prenyl group binding site (CAAX box).
316401012647	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
316401012648	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
316401012649	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
316401012650	1 probable transmembrane helix predicted for ETEC3167 by TMHMM2.0 at aa 33-55
316401012651	Signal peptide predicted for ETEC3168 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.571 between residues 21 and 22
316401012652	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401012653	O-methyltransferase; Region: Methyltransf_2; pfam00891
316401012654	Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723
316401012655	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
316401012656	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
316401012657	putative acyl-acceptor binding pocket; other site
316401012658	1 probable transmembrane helix predicted for ETEC3171 by TMHMM2.0 at aa 21-43
316401012659	Phosphopantetheine attachment site; Region: PP-binding; cl09936
316401012660	PS00012 Phosphopantetheine attachment site.
316401012661	acyl carrier protein; Provisional; Region: PRK05350
316401012662	Predicted membrane protein [Function unknown]; Region: COG4648
316401012663	6 probable transmembrane helices predicted for ETEC3174 by TMHMM2.0 at aa 13-30, 34-51, 58-80, 84-106, 138-157 and 162-184
316401012664	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
316401012665	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
316401012666	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
316401012667	acyl-activating enzyme (AAE) consensus motif; other site
316401012668	acyl-activating enzyme (AAE) consensus motif; other site
316401012669	AMP binding site [chemical binding]; other site
316401012670	active site
316401012671	CoA binding site [chemical binding]; other site
316401012672	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
316401012673	active site 2 [active]
316401012674	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
316401012675	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
316401012676	Ligand binding site; other site
316401012677	Putative Catalytic site; other site
316401012678	DXD motif; other site
316401012679	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
316401012680	putative acyl-acceptor binding pocket; other site
316401012681	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
316401012682	active site
316401012683	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
316401012684	Signal peptide predicted for ETEC3179 by SignalP 2.0 HMM (Signal peptide probability 0.990) with cleavage site probability 0.711 between residues 17 and 18
316401012685	Predicted exporter [General function prediction only]; Region: COG4258
316401012686	11 probable transmembrane helices predicted for ETEC3180 by TMHMM2.0 at aa 231-250, 257-279, 283-305, 326-348, 352-374, 402-421, 603-625, 632-654, 658-680, 687-709 and 714-736
316401012687	Protein of unknown function (DUF3261); Region: DUF3261; pfam11659
316401012688	Signal peptide predicted for ETEC3181 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 24 and 25
316401012689	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401012690	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185
316401012691	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
316401012692	dimer interface [polypeptide binding]; other site
316401012693	active site
316401012694	PS00606 Beta-ketoacyl synthases active site.
316401012695	Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289
316401012696	putative active site 1 [active]
316401012697	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
316401012698	3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831
316401012699	NAD(P) binding site [chemical binding]; other site
316401012700	active site
316401012701	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116
316401012702	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
316401012703	dimer interface [polypeptide binding]; other site
316401012704	active site
316401012705	Transcriptional regulators [Transcription]; Region: PurR; COG1609
316401012706	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
316401012707	DNA binding site [nucleotide binding]
316401012708	domain linker motif; other site
316401012709	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
316401012710	putative dimerization interface [polypeptide binding]; other site
316401012711	putative ligand binding site [chemical binding]; other site
316401012712	PS00626 Regulator of chromosome condensation (RCC1) signature 2.
316401012713	PS00356 Bacterial regulatory proteins, lacI family signature.
316401012714	putative transposase OrfB; Reviewed; Region: PHA02517
316401012715	HTH-like domain; Region: HTH_21; pfam13276
316401012716	Integrase core domain; Region: rve; pfam00665
316401012717	Integrase core domain; Region: rve_2; pfam13333
316401012718	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
316401012719	Helix-turn-helix domain; Region: HTH_28; pfam13518
316401012720	Helix-turn-helix domain; Region: HTH_28; pfam13518
316401012721	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
316401012722	active site
316401012723	phosphorylation site [posttranslational modification]
316401012724	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
316401012725	active site
316401012726	P-loop; other site
316401012727	phosphorylation site [posttranslational modification]
316401012728	Similar, although with an insertion sequence transposed into the protein, to Erwinia carotovora subsp. atroseptica (pectobacterium atrosepticum). putative membrane protein. UniProt:Q6D0M3 (EMBL:BX950851 (419 aa) fasta scores: E()=6.1e-118, 83.886% id in 422 aa. It is faintly possible that this CDS, although interrupted could be transcribed as two separate CDS
316401012729	transposase/IS protein; Provisional; Region: PRK09183
316401012730	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316401012731	Walker A motif; other site
316401012732	ATP binding site [chemical binding]; other site
316401012733	Walker B motif; other site
316401012734	PS00017 ATP/GTP-binding site motif A (P-loop).
316401012735	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
316401012736	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
316401012737	DNA-binding interface [nucleotide binding]; DNA binding site
316401012738	Integrase core domain; Region: rve; pfam00665
316401012739	Transposase; Region: HTH_Tnp_1; pfam01527
316401012740	deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269
316401012741	active site
316401012742	catalytic residues [active]
316401012743	PS00290 Immunoglobulins and major histocompatibility complex proteins signature.
316401012744	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
316401012745	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401012746	putative substrate translocation pore; other site
316401012747	12 probable transmembrane helices predicted for ETEC3196 by TMHMM2.0 at aa 20-42, 57-79, 86-105, 109-128, 149-171, 207-224, 256-278, 293-312, 319-336, 340-362, 375-397 and 401-423
316401012748	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
316401012749	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
316401012750	substrate binding site [chemical binding]; other site
316401012751	dimer interface [polypeptide binding]; other site
316401012752	ATP binding site [chemical binding]; other site
316401012753	DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681
316401012754	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
316401012755	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
316401012756	PS00894 Bacterial regulatory proteins, deoR family signature.
316401012757	Protein of unknown function (DUF3279); Region: DUF3279; pfam11682
316401012758	Protein of unknown function (DUF3279); Region: DUF3279; pfam11682
316401012759	PS00190 Cytochrome c family heme-binding site signature.
316401012760	Protein of unknown function (DUF3296); Region: DUF3296; pfam11726
316401012761	Transposase; Region: HTH_Tnp_1; pfam01527
316401012762	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
316401012763	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
316401012764	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
316401012765	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
316401012766	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
316401012767	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
316401012768	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
316401012769	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
316401012770	Protein of unknown function (DUF433); Region: DUF433; cl01030
316401012771	MULE transposase domain; Region: MULE; pfam10551
316401012772	PS01007 Transposases, Mutator family, signature.
316401012773	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930
316401012774	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
316401012775	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
316401012776	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
316401012777	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
316401012778	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
316401012779	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
316401012780	Transposase; Region: HTH_Tnp_1; pfam01527
316401012781	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
316401012783	1 probable transmembrane helix predicted for ETEC3214 by TMHMM2.0 at aa 12-34
316401012784	Signal peptide predicted for ETEC3214 by SignalP 2.0 HMM (Signal peptide probability 0.975) with cleavage site probability 0.594 between residues 31 and 32
316401012785	Predicted GTPase [General function prediction only]; Region: COG3596
316401012786	YfjP GTPase; Region: YfjP; cd11383
316401012787	G1 box; other site
316401012788	GTP/Mg2+ binding site [chemical binding]; other site
316401012789	Switch I region; other site
316401012790	G2 box; other site
316401012791	Switch II region; other site
316401012792	G3 box; other site
316401012793	G4 box; other site
316401012794	G5 box; other site
316401012795	PS00017 ATP/GTP-binding site motif A (P-loop).
316401012796	this CDS has been disrupted by an IS element insertion
316401012797	Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044
316401012798	homodimer interface [polypeptide binding]; other site
316401012799	putative GKAP docking site [polypeptide binding]; other site
316401012800	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
316401012801	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
316401012802	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
316401012803	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
316401012804	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
316401012805	Transposase; Region: HTH_Tnp_1; pfam01527
316401012806	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
316401012807	Signal peptide predicted for ETEC3219 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 25 and 26
316401012808	Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006
316401012809	Domain of unknown function (DUF932); Region: DUF932; pfam06067
316401012810	Antirestriction protein; Region: Antirestrict; pfam03230
316401012811	DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003
316401012812	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
316401012813	MPN+ (JAMM) motif; other site
316401012814	Zinc-binding site [ion binding]; other site
316401012815	PS01302 DNA repair protein radC family signature.
316401012816	YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154
316401012817	Protein of unknown function (DUF1219); Region: DUF1219; pfam06755
316401012818	Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117
316401012819	Methyltransferase domain; Region: Methyltransf_27; pfam13708
316401012820	putative general secretion pathway protein YghD; Provisional; Region: PRK09731
316401012821	1 probable transmembrane helix predicted for ETEC3228 by TMHMM2.0 at aa 38-57
316401012822	type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709
316401012823	GspL-like protein; Provisional; Region: PRK09662
316401012824	1 probable transmembrane helix predicted for ETEC3229 by TMHMM2.0 at aa 131-150
316401012825	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401012826	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
316401012827	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
316401012828	type II secretion system protein J; Region: gspJ; TIGR01711
316401012829	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
316401012830	Signal peptide predicted for ETEC3231 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.984 between residues 27 and 28
316401012831	PS00409 Prokaryotic N-terminal methylation site.
316401012832	1 probable transmembrane helix predicted for ETEC3231 by TMHMM2.0 at aa 7-26
316401012833	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
316401012834	type II secretion system protein I; Region: gspI; TIGR01707
316401012835	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
316401012836	1 probable transmembrane helix predicted for ETEC3232 by TMHMM2.0 at aa 7-29
316401012837	Signal peptide predicted for ETEC3232 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.536 between residues 23 and 24
316401012838	PS00409 Prokaryotic N-terminal methylation site.
316401012839	Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963
316401012840	Type II transport protein GspH; Region: GspH; pfam12019
316401012841	Signal peptide predicted for ETEC3233 by SignalP 2.0 HMM (Signal peptide probability 0.792) with cleavage site probability 0.501 between residues 30 and 31
316401012842	1 probable transmembrane helix predicted for ETEC3233 by TMHMM2.0 at aa 7-29
316401012843	PS00409 Prokaryotic N-terminal methylation site.
316401012844	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
316401012845	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
316401012846	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
316401012847	1 probable transmembrane helix predicted for ETEC3234 by TMHMM2.0 at aa 12-34
316401012848	PS00409 Prokaryotic N-terminal methylation site.
316401012849	type II secretion system protein F; Region: GspF; TIGR02120
316401012850	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
316401012851	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
316401012852	3 probable transmembrane helices predicted for ETEC3235 by TMHMM2.0 at aa 172-194, 221-240 and 372-394
316401012853	PS00874 Bacterial type II secretion system protein F signature.
316401012854	type II secretion system protein E; Region: type_II_gspE; TIGR02533
316401012855	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
316401012856	Walker A motif; other site
316401012857	ATP binding site [chemical binding]; other site
316401012858	Walker B motif; other site
316401012859	PS00662 Bacterial type II secretion system protein E signature.
316401012860	PS00017 ATP/GTP-binding site motif A (P-loop).
316401012861	type II secretion system protein D; Region: type_II_gspD; TIGR02517
316401012862	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
316401012863	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
316401012864	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
316401012865	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
316401012866	Signal peptide predicted for ETEC3237 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 40 and 41
316401012867	putative type II secretion protein GspC; Provisional; Region: PRK09681
316401012868	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
316401012869	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
316401012870	Signal peptide predicted for ETEC3239 by SignalP 2.0 HMM (Signal peptide probability 0.979) with cleavage site probability 0.463 between residues 32 and 33
316401012871	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401012872	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
316401012873	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
316401012874	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
316401012875	7 probable transmembrane helices predicted for ETEC3240 by TMHMM2.0 at aa 10-32, 102-120, 124-141, 148-167, 177-196, 209-231 and 246-268
316401012876	Domain of unknown function (DUF4092); Region: DUF4092; pfam13322
316401012877	Peptidase M60-like family; Region: M60-like; pfam13402
316401012878	PS00178 Aminoacyl-transfer RNA synthetases class-I signature.
316401012879	Signal peptide predicted for ETEC3241 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.462 between residues 33 and 34
316401012880	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401012881	glycolate transporter; Provisional; Region: PRK09695
316401012882	L-lactate permease; Region: Lactate_perm; cl00701
316401012883	13 probable transmembrane helices predicted for ETEC3242 by TMHMM2.0 at aa 13-35, 40-62, 69-91, 129-151, 158-180, 190-212, 224-246, 307-324, 331-348, 377-399, 411-430, 440-462 and 537-559
316401012884	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401012885	Signal peptide predicted for ETEC3242 by SignalP 2.0 HMM (Signal peptide probability 0.948) with cleavage site probability 0.941 between residues 33 and 34
316401012886	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
316401012887	active site
316401012888	hypothetical protein; Provisional; Region: PRK09732
316401012889	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
316401012890	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
316401012891	Cysteine-rich domain; Region: CCG; pfam02754
316401012892	Cysteine-rich domain; Region: CCG; pfam02754
316401012893	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401012894	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401012895	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
316401012896	FAD binding domain; Region: FAD_binding_4; pfam01565
316401012897	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
316401012898	FAD binding domain; Region: FAD_binding_4; pfam01565
316401012899	DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990
316401012900	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
316401012901	DNA-binding site [nucleotide binding]; DNA binding site
316401012902	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
316401012903	PS00043 Bacterial regulatory proteins, gntR family signature.
316401012904	acyl-CoA synthetase; Validated; Region: PRK09192
316401012905	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
316401012906	acyl-activating enzyme (AAE) consensus motif; other site
316401012907	active site
316401012908	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
316401012909	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
316401012910	NAD(P) binding site [chemical binding]; other site
316401012911	active site
316401012912	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
316401012913	PS00012 Phosphopantetheine attachment site.
316401012914	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
316401012915	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
316401012916	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
316401012917	catalytic residue [active]
316401012918	PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site.
316401012919	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
316401012920	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
316401012921	6 probable transmembrane helices predicted for ETEC3253 by TMHMM2.0 at aa 38-60, 86-108, 121-143, 302-321, 328-350 and 360-382
316401012922	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
316401012923	Predicted permeases [General function prediction only]; Region: COG0795
316401012924	5 probable transmembrane helices predicted for ETEC3254 by TMHMM2.0 at aa 15-32, 52-74, 102-121, 294-313 and 323-345
316401012925	Signal peptide predicted for ETEC3254 by SignalP 2.0 HMM (Signal peptide probability 0.908) with cleavage site probability 0.759 between residues 31 and 32
316401012926	Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695
316401012927	Signal peptide predicted for ETEC3255 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.994 between residues 20 and 21
316401012928	PS00017 ATP/GTP-binding site motif A (P-loop).
316401012929	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401012930	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
316401012931	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
316401012932	8 probable transmembrane helices predicted for ETEC3257 by TMHMM2.0 at aa 36-58, 96-118, 133-155, 176-198, 260-282, 312-334, 354-376 and 396-418
316401012933	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401012934	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
316401012935	Thymidylate kinase; Region: Thymidylate_kin; pfam02223
316401012936	active site
316401012937	PS00017 ATP/GTP-binding site motif A (P-loop).
316401012938	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401012939	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
316401012940	TMP-binding site; other site
316401012941	ATP-binding site [chemical binding]; other site
316401012942	PS00017 ATP/GTP-binding site motif A (P-loop).
316401012943	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
316401012944	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
316401012945	TMP-binding site; other site
316401012946	ATP-binding site [chemical binding]; other site
316401012947	PS00017 ATP/GTP-binding site motif A (P-loop).
316401012948	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
316401012949	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
316401012950	10 probable transmembrane helices predicted for ETEC3261 by TMHMM2.0 at aa 10-32, 52-74, 94-116, 123-140, 155-177, 207-224, 234-256, 381-403, 418-440 and 474-496
316401012951	PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature.
316401012952	bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507
316401012953	CHAP domain; Region: CHAP; pfam05257
316401012954	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
316401012955	1 probable transmembrane helix predicted for ETEC3262 by TMHMM2.0 at aa 66-85
316401012956	putative S-transferase; Provisional; Region: PRK11752
316401012957	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
316401012958	C-terminal domain interface [polypeptide binding]; other site
316401012959	GSH binding site (G-site) [chemical binding]; other site
316401012960	dimer interface [polypeptide binding]; other site
316401012961	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
316401012962	dimer interface [polypeptide binding]; other site
316401012963	N-terminal domain interface [polypeptide binding]; other site
316401012964	active site
316401012965	1 probable transmembrane helix predicted for ETEC3263 by TMHMM2.0 at aa 146-168
316401012966	hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413
316401012967	PS01097 Hydrogenases expression/synthesis hupF/hypC family signature.
316401012968	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
316401012969	hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380
316401012970	PS01249 Hydrogenases expression/synthesis hypA family signature.
316401012971	hydrogenase 2-specific chaperone; Provisional; Region: PRK10465
316401012972	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
316401012973	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
316401012974	putative substrate-binding site; other site
316401012975	nickel binding site [ion binding]; other site
316401012976	hydrogenase 2 large subunit; Provisional; Region: PRK10467
316401012977	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
316401012978	PS00508 Nickel-dependent hydrogenases large subunit signature 2.
316401012979	PS00507 Nickel-dependent hydrogenases large subunit signature 1.
316401012980	putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881
316401012981	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
316401012982	10 probable transmembrane helices predicted for ETEC3269 by TMHMM2.0 at aa 13-32, 52-74, 86-108, 128-150, 171-193, 208-227, 246-268, 283-302, 315-337 and 352-374
316401012983	hydrogenase 2 protein HybA; Provisional; Region: PRK10882
316401012984	4Fe-4S binding domain; Region: Fer4_6; pfam12837
316401012985	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401012986	Signal peptide predicted for ETEC3270 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 26 and 27
316401012987	hydrogenase 2 small subunit; Provisional; Region: PRK10468
316401012988	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
316401012989	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
316401012990	1 probable transmembrane helix predicted for ETEC3271 by TMHMM2.0 at aa 332-354
316401012991	Signal peptide predicted for ETEC3271 by SignalP 2.0 HMM (Signal peptide probability 0.992) with cleavage site probability 0.853 between residues 37 and 38
316401012992	Protein of unknown function (DUF2623); Region: DUF2623; pfam11115
316401012994	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
316401012995	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
316401012996	active site
316401012997	catalytic tetrad [active]
316401012998	hypothetical protein; Provisional; Region: PRK05208
316401012999	3 probable transmembrane helices predicted for ETEC3276 by TMHMM2.0 at aa 10-32, 53-75 and 136-155
316401013000	oxidoreductase; Provisional; Region: PRK07985
316401013001	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
316401013002	NAD binding site [chemical binding]; other site
316401013003	metal binding site [ion binding]; metal-binding site
316401013004	active site
316401013005	PS00061 Short-chain dehydrogenases/reductases family signature.
316401013006	biopolymer transport protein ExbD; Provisional; Region: PRK11267
316401013007	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
316401013008	1 probable transmembrane helix predicted for ETEC3278 by TMHMM2.0 at aa 20-42
316401013009	biopolymer transport protein ExbB; Provisional; Region: PRK10414
316401013010	3 probable transmembrane helices predicted for ETEC3279 by TMHMM2.0 at aa 20-42, 131-153 and 177-199
316401013011	cystathionine beta-lyase; Provisional; Region: PRK08114
316401013012	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
316401013013	homodimer interface [polypeptide binding]; other site
316401013014	substrate-cofactor binding pocket; other site
316401013015	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316401013016	catalytic residue [active]
316401013017	PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site.
316401013018	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
316401013019	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
316401013020	4 probable transmembrane helices predicted for ETEC3281 by TMHMM2.0 at aa 26-48, 68-90, 158-180 and 190-212
316401013021	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
316401013022	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
316401013023	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316401013024	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316401013025	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
316401013026	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
316401013027	dimer interface [polypeptide binding]; other site
316401013028	active site
316401013029	metal binding site [ion binding]; metal-binding site
316401013030	PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide.
316401013031	PS00913 Iron-containing alcohol dehydrogenases signature 1.
316401013032	PS00060 Iron-containing alcohol dehydrogenases signature 2.
316401013033	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
316401013034	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
316401013035	active site
316401013036	catalytic tetrad [active]
316401013037	PS00798 Aldo/keto reductase family signature 1.
316401013038	PS00062 Aldo/keto reductase family signature 2.
316401013039	PS00063 Aldo/keto reductase family putative active site signature.
316401013040	Protein of unknown function (DUF3828); Region: DUF3828; pfam12883
316401013041	Signal peptide predicted for ETEC3285 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 18 and 19
316401013042	putative outer membrane lipoprotein; Provisional; Region: PRK09973
316401013043	Signal peptide predicted for ETEC3286 by SignalP 2.0 HMM (Signal peptide probability 0.963) with cleavage site probability 0.753 between residues 23 and 24
316401013044	1 probable transmembrane helix predicted for ETEC3286 by TMHMM2.0 at aa 4-21
316401013045	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401013046	hypothetical protein; Provisional; Region: PRK01254
316401013047	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
316401013048	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
316401013049	PS01278 Uncharacterized protein family UPF0004 signature.
316401013050	FtsI repressor; Provisional; Region: PRK10883
316401013051	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
316401013052	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
316401013053	Signal peptide predicted for ETEC3288 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.990 between residues 27 and 28
316401013054	1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018
316401013055	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
316401013056	putative acyl-acceptor binding pocket; other site
316401013057	1 probable transmembrane helix predicted for ETEC3289 by TMHMM2.0 at aa 2-24
316401013058	DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062
316401013059	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
316401013060	CAP-like domain; other site
316401013061	active site
316401013062	primary dimer interface [polypeptide binding]; other site
316401013063	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
316401013064	putative ABC transporter periplasmic-binding protein; Provisional; Region: PRK09755
316401013065	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
316401013066	peptide binding site [polypeptide binding]; other site
316401013067	Signal peptide predicted for ETEC3291 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 20 and 21
316401013068	antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870
316401013069	toxin interface [polypeptide binding]; other site
316401013070	putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830
316401013071	Zn binding site [ion binding]; other site
316401013072	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
316401013073	non-specific DNA binding site [nucleotide binding]; other site
316401013074	salt bridge; other site
316401013075	sequence-specific DNA binding site [nucleotide binding]; other site
316401013076	Motility quorum-sensing regulator (MqsR); Region: MqsR; cd12869
316401013077	peptide binding site [polypeptide binding]; other site
316401013078	DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449
316401013079	TIGR00156 family protein; Region: TIGR00156
316401013080	Signal peptide predicted for ETEC3295 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 20 and 21
316401013081	DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336
316401013082	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316401013083	active site
316401013084	phosphorylation site [posttranslational modification]
316401013085	intermolecular recognition site; other site
316401013086	dimerization interface [polypeptide binding]; other site
316401013087	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
316401013088	DNA binding site [nucleotide binding]
316401013089	sensor protein QseC; Provisional; Region: PRK10337
316401013090	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316401013091	dimer interface [polypeptide binding]; other site
316401013092	phosphorylation site [posttranslational modification]
316401013093	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316401013094	ATP binding site [chemical binding]; other site
316401013095	Mg2+ binding site [ion binding]; other site
316401013096	G-X-G motif; other site
316401013097	Signal peptide predicted for ETEC3297 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.780 between residues 34 and 35
316401013098	2 probable transmembrane helices predicted for ETEC3297 by TMHMM2.0 at aa 10-32 and 160-182
316401013099	IS1 transposase; Region: DDE_Tnp_IS1; pfam03400
316401013100	Signal peptide predicted for ETEC3299 by SignalP 2.0 HMM (Signal peptide probability 0.732) with cleavage site probability 0.557 between residues 27 and 28
316401013101	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
316401013102	Uncharacterized conserved protein [Function unknown]; Region: COG1359
316401013103	PS00867 Carbamoyl-phosphate synthase subdomain signature 2.
316401013104	DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055
316401013105	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316401013106	ATP binding site [chemical binding]; other site
316401013107	Mg2+ binding site [ion binding]; other site
316401013108	G-X-G motif; other site
316401013109	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
316401013110	anchoring element; other site
316401013111	dimer interface [polypeptide binding]; other site
316401013112	ATP binding site [chemical binding]; other site
316401013113	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
316401013114	active site
316401013115	metal binding site [ion binding]; metal-binding site
316401013116	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
316401013117	PS00177 DNA topoisomerase II signature.
316401013118	esterase YqiA; Provisional; Region: PRK11071
316401013119	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
316401013120	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
316401013121	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
316401013122	active site
316401013123	metal binding site [ion binding]; metal-binding site
316401013124	hexamer interface [polypeptide binding]; other site
316401013125	putative dehydrogenase; Provisional; Region: PRK11039
316401013126	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
316401013127	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
316401013128	dimer interface [polypeptide binding]; other site
316401013129	ADP-ribose binding site [chemical binding]; other site
316401013130	active site
316401013131	nudix motif; other site
316401013132	metal binding site [ion binding]; metal-binding site
316401013133	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
316401013134	Signal peptide predicted for ETEC3307 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.985 between residues 22 and 23
316401013135	hypothetical protein; Provisional; Region: PRK11653
316401013136	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
316401013137	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
316401013138	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
316401013139	putative active site [active]
316401013140	metal binding site [ion binding]; metal-binding site
316401013141	zinc transporter ZupT; Provisional; Region: PRK04201
316401013142	ZIP Zinc transporter; Region: Zip; pfam02535
316401013143	Signal peptide predicted for ETEC3312 by SignalP 2.0 HMM (Signal peptide probability 0.908) with cleavage site probability 0.771 between residues 25 and 26
316401013144	6 probable transmembrane helices predicted for ETEC3312 by TMHMM2.0 at aa 5-25, 32-54, 64-81, 169-191, 195-217 and 234-256
316401013145	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
316401013146	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
316401013147	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960
316401013148	IS1 transposase; Region: DDE_Tnp_IS1; pfam03400
316401013149	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
316401013150	PapC N-terminal domain; Region: PapC_N; pfam13954
316401013151	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
316401013152	PapC C-terminal domain; Region: PapC_C; pfam13953
316401013153	Signal peptide predicted for ETEC3317 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 33 and 34
316401013154	1 probable transmembrane helix predicted for ETEC3317 by TMHMM2.0 at aa 13-35
316401013155	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401013156	PS01151 Fimbrial biogenesis outer membrane usher protein signature.
316401013157	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
316401013158	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
316401013159	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
316401013160	Signal peptide predicted for ETEC3318 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.991 between residues 25 and 26
316401013161	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401013162	1 probable transmembrane helix predicted for ETEC3318 by TMHMM2.0 at aa 9-28
316401013163	PS00635 Gram-negative pili assembly chaperone signature.
316401013164	Fimbrial protein; Region: Fimbrial; pfam00419
316401013165	Signal peptide predicted for ETEC3319 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.999 between residues 21 and 22
316401013166	glycogen synthesis protein GlgS; Provisional; Region: PRK02922
316401013167	Protein of unknown function (DUF1449); Region: DUF1449; pfam07290
316401013168	3 probable transmembrane helices predicted for ETEC3321 by TMHMM2.0 at aa 13-35, 63-85 and 97-119
316401013169	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
316401013170	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
316401013171	2 probable transmembrane helices predicted for ETEC3322 by TMHMM2.0 at aa 11-33 and 46-68
316401013172	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
316401013173	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
316401013174	putative ribose interaction site [chemical binding]; other site
316401013175	putative ADP binding site [chemical binding]; other site
316401013176	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
316401013177	active site
316401013178	nucleotide binding site [chemical binding]; other site
316401013179	HIGH motif; other site
316401013180	KMSKS motif; other site
316401013181	PS00583 pfkB family of carbohydrate kinases signature 1.
316401013182	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
316401013183	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
316401013184	metal binding triad; other site
316401013185	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
316401013186	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
316401013187	metal binding triad; other site
316401013188	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
316401013189	Uncharacterized conserved protein [Function unknown]; Region: COG3025
316401013190	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
316401013191	putative active site [active]
316401013192	putative metal binding residues [ion binding]; other site
316401013193	signature motif; other site
316401013194	putative triphosphate binding site [ion binding]; other site
316401013195	CHAD domain; Region: CHAD; pfam05235
316401013196	SH3 domain-containing protein; Provisional; Region: PRK10884
316401013197	Bacterial SH3 domain homologues; Region: SH3b; smart00287
316401013198	Signal peptide predicted for ETEC3326 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.989 between residues 22 and 23
316401013199	1 probable transmembrane helix predicted for ETEC3326 by TMHMM2.0 at aa 173-195
316401013200	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
316401013201	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
316401013202	active site
316401013203	NTP binding site [chemical binding]; other site
316401013204	metal binding triad [ion binding]; metal-binding site
316401013205	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
316401013206	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
316401013207	Zn2+ binding site [ion binding]; other site
316401013208	Mg2+ binding site [ion binding]; other site
316401013209	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
316401013210	7 probable transmembrane helices predicted for ETEC3328 by TMHMM2.0 at aa 13-35, 50-69, 90-109, 119-136, 187-209, 224-246 and 253-272
316401013211	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
316401013212	homooctamer interface [polypeptide binding]; other site
316401013213	active site
316401013214	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
316401013215	5 probable transmembrane helices predicted for ETEC3330 by TMHMM2.0 at aa 4-26, 53-75, 80-102, 109-131 and 136-158
316401013216	transcriptional activator TtdR; Provisional; Region: PRK09801
316401013217	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401013218	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
316401013219	putative effector binding pocket; other site
316401013220	putative dimerization interface [polypeptide binding]; other site
316401013221	PS00044 Bacterial regulatory proteins, lysR family signature.
316401013222	tartrate dehydratase subunit alpha; Validated; Region: PRK08230
316401013223	L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228
316401013224	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
316401013225	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
316401013226	transmembrane helices; other site
316401013227	12 probable transmembrane helices predicted for ETEC3334 by TMHMM2.0 at aa 7-29, 33-50, 52-74, 94-116, 137-154, 197-219, 232-254, 306-328, 341-363, 378-400, 420-442 and 462-484
316401013228	UGMP family protein; Validated; Region: PRK09604
316401013229	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
316401013230	PS01016 Glycoprotease family signature.
316401013231	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
316401013232	PS01181 Ribosomal protein S21 signature.
316401013233	DNA primase; Validated; Region: dnaG; PRK05667
316401013234	CHC2 zinc finger; Region: zf-CHC2; pfam01807
316401013235	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
316401013236	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
316401013237	active site
316401013238	metal binding site [ion binding]; metal-binding site
316401013239	interdomain interaction site; other site
316401013240	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
316401013241	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
316401013242	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
316401013243	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
316401013244	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
316401013245	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
316401013246	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
316401013247	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
316401013248	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
316401013249	DNA binding residues [nucleotide binding]
316401013250	PS00715 Sigma-70 factors family signature 1.
316401013251	PS00716 Sigma-70 factors family signature 2.
316401013252	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
316401013253	active site
316401013254	SUMO-1 interface [polypeptide binding]; other site
316401013255	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
316401013256	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
316401013257	FAD binding pocket [chemical binding]; other site
316401013258	FAD binding motif [chemical binding]; other site
316401013259	phosphate binding motif [ion binding]; other site
316401013260	NAD binding pocket [chemical binding]; other site
316401013261	Predicted transcriptional regulators [Transcription]; Region: COG1695
316401013262	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
316401013263	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316401013264	PAS fold; Region: PAS_3; pfam08447
316401013265	putative active site [active]
316401013266	heme pocket [chemical binding]; other site
316401013267	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
316401013268	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316401013269	dimer interface [polypeptide binding]; other site
316401013270	putative CheW interface [polypeptide binding]; other site
316401013271	1 probable transmembrane helix predicted for ETEC3342 by TMHMM2.0 at aa 172-194
316401013272	putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522
316401013273	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
316401013274	inhibitor-cofactor binding pocket; inhibition site
316401013275	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316401013276	catalytic residue [active]
316401013277	Signal peptide predicted for ETEC3343 by SignalP 2.0 HMM (Signal peptide probability 0.813) with cleavage site probability 0.794 between residues 26 and 27
316401013278	PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site.
316401013279	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
316401013280	dimer interface [polypeptide binding]; other site
316401013281	putative tRNA-binding site [nucleotide binding]; other site
316401013282	DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339
316401013283	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
316401013284	DNA binding site [nucleotide binding]
316401013285	domain linker motif; other site
316401013286	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
316401013287	putative dimerization interface [polypeptide binding]; other site
316401013288	putative ligand binding site [chemical binding]; other site
316401013289	PS00356 Bacterial regulatory proteins, lacI family signature.
316401013290	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
316401013291	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
316401013292	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
316401013293	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
316401013294	Beta galactosidase small chain; Region: Bgal_small_N; pfam02929
316401013295	PS00719 Glycosyl hydrolases family 2 signature 1.
316401013296	PS00608 Glycosyl hydrolases family 2 acid/base catalyst.
316401013297	cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202
316401013298	inner membrane transporter YjeM; Provisional; Region: PRK15238
316401013299	Signal peptide predicted for ETEC3348 by SignalP 2.0 HMM (Signal peptide probability 0.640) with cleavage site probability 0.507 between residues 26 and 27
316401013300	12 probable transmembrane helices predicted for ETEC3348 by TMHMM2.0 at aa 12-29, 42-64, 93-115, 120-142, 155-177, 197-219, 232-254, 282-304, 332-354, 364-386, 407-426 and 430-452
316401013301	PS00589 PTS HPR component serine phosphorylation site signature.
316401013302	Signal peptide predicted for ETEC3349 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.772 between residues 24 and 25
316401013303	alpha-glucosidase; Provisional; Region: PRK10137
316401013304	Protein of unknown function, DUF608; Region: DUF608; pfam04685
316401013305	Trehalase; Region: Trehalase; cl17346
316401013306	Signal peptide predicted for ETEC3350 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.976 between residues 22 and 23
316401013307	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
316401013308	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
316401013309	active site
316401013310	FMN binding site [chemical binding]; other site
316401013311	2,4-decadienoyl-CoA binding site; other site
316401013312	catalytic residue [active]
316401013313	4Fe-4S cluster binding site [ion binding]; other site
316401013314	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
316401013315	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
316401013316	non-specific DNA binding site [nucleotide binding]; other site
316401013317	salt bridge; other site
316401013318	sequence-specific DNA binding site [nucleotide binding]; other site
316401013319	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680
316401013320	SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001
316401013321	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316401013322	S-adenosylmethionine binding site [chemical binding]; other site
316401013323	PS00092 N-6 Adenine-specific DNA methylases signature.
316401013324	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
316401013325	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
316401013326	putative active site [active]
316401013327	Signal peptide predicted for ETEC3356 by SignalP 2.0 HMM (Signal peptide probability 0.992) with cleavage site probability 0.850 between residues 36 and 37
316401013328	1 probable transmembrane helix predicted for ETEC3356 by TMHMM2.0 at aa 21-40
316401013329	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
316401013330	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
316401013331	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
316401013332	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
316401013333	9 probable transmembrane helices predicted for ETEC3358 by TMHMM2.0 at aa 10-29, 42-64, 88-110, 115-137, 142-161, 198-220, 235-257, 264-286 and 290-312
316401013334	serine/threonine transporter SstT; Provisional; Region: PRK13628
316401013335	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
316401013336	8 probable transmembrane helices predicted for ETEC3359 by TMHMM2.0 at aa 13-35, 50-72, 84-106, 141-163, 183-205, 215-237, 292-314 and 329-351
316401013337	Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688
316401013338	4 probable transmembrane helices predicted for ETEC3360 by TMHMM2.0 at aa 5-22, 37-59, 72-89 and 134-156
316401013339	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
316401013340	galactarate dehydratase; Region: galactar-dH20; TIGR03248
316401013341	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
316401013342	Glucuronate isomerase; Region: UxaC; pfam02614
316401013343	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
316401013344	D-galactonate transporter; Region: 2A0114; TIGR00893
316401013345	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401013346	putative substrate translocation pore; other site
316401013347	11 probable transmembrane helices predicted for ETEC3363 by TMHMM2.0 at aa 47-66, 87-109, 119-141, 176-198, 203-225, 272-294, 309-331, 344-363, 368-390, 403-425 and 430-452
316401013348	DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523
316401013349	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
316401013350	DNA-binding site [nucleotide binding]; DNA binding site
316401013351	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
316401013352	PS00043 Bacterial regulatory proteins, gntR family signature.
316401013353	PS00904 Protein prenyltransferases alpha subunit repeat signature.
316401013354	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
316401013355	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
316401013356	6 probable transmembrane helices predicted for ETEC3365 by TMHMM2.0 at aa 19-38, 42-64, 71-93, 126-148, 153-175 and 190-212
316401013357	EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629
316401013358	Signal peptide predicted for ETEC3366 by SignalP 2.0 HMM (Signal peptide probability 0.991) with cleavage site probability 0.418 between residues 29 and 30
316401013359	1 probable transmembrane helix predicted for ETEC3366 by TMHMM2.0 at aa 12-31
316401013360	Protein of unknown function (DUF1090); Region: DUF1090; pfam06476
316401013361	Signal peptide predicted for ETEC3367 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.953 between residues 20 and 21
316401013362	Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575
316401013363	1 probable transmembrane helix predicted for ETEC3368 by TMHMM2.0 at aa 81-98
316401013364	Predicted membrane protein [Function unknown]; Region: COG5393
316401013365	2 probable transmembrane helices predicted for ETEC3369 by TMHMM2.0 at aa 50-72 and 82-104
316401013366	YqjK-like protein; Region: YqjK; pfam13997
316401013367	1 probable transmembrane helix predicted for ETEC3370 by TMHMM2.0 at aa 46-65
316401013368	Predicted membrane protein [Function unknown]; Region: COG2259
316401013369	4 probable transmembrane helices predicted for ETEC3371 by TMHMM2.0 at aa 7-29, 44-66, 71-88 and 103-122
316401013370	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
316401013371	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
316401013372	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
316401013373	putative dimer interface [polypeptide binding]; other site
316401013374	N-terminal domain interface [polypeptide binding]; other site
316401013375	putative substrate binding pocket (H-site) [chemical binding]; other site
316401013376	Predicted membrane protein [Function unknown]; Region: COG3152
316401013377	3 probable transmembrane helices predicted for ETEC3373 by TMHMM2.0 at aa 23-40, 53-70 and 83-105
316401013378	Predicted membrane protein [Function unknown]; Region: COG3152
316401013379	3 probable transmembrane helices predicted for ETEC3374 by TMHMM2.0 at aa 23-45, 49-71 and 78-100
316401013380	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401013381	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
316401013382	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
316401013383	dimerization interface [polypeptide binding]; other site
316401013384	PS00044 Bacterial regulatory proteins, lysR family signature.
316401013385	Pirin-related protein [General function prediction only]; Region: COG1741
316401013386	Pirin; Region: Pirin; pfam02678
316401013387	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
316401013388	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
316401013389	serine transporter; Region: stp; TIGR00814
316401013390	11 probable transmembrane helices predicted for ETEC3379 by TMHMM2.0 at aa 17-39, 44-66, 91-113, 128-150, 163-185, 200-222, 243-265, 297-319, 342-364, 368-390 and 402-421
316401013391	L-serine dehydratase TdcG; Provisional; Region: PRK15040
316401013392	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
316401013393	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
316401013394	PS00017 ATP/GTP-binding site motif A (P-loop).
316401013395	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
316401013396	homotrimer interaction site [polypeptide binding]; other site
316401013397	putative active site [active]
316401013398	PS01094 Uncharacterized protein family UPF0076 signature.
316401013399	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
316401013400	Pyruvate formate lyase 1; Region: PFL1; cd01678
316401013401	coenzyme A binding site [chemical binding]; other site
316401013402	active site
316401013403	catalytic residues [active]
316401013404	glycine loop; other site
316401013405	PS00850 Glycine radical signature.
316401013406	propionate/acetate kinase; Provisional; Region: PRK12379
316401013407	Acetokinase family; Region: Acetate_kinase; cl17229
316401013408	PS01076 Acetate and butyrate kinases family signature 2.
316401013409	PS01075 Acetate and butyrate kinases family signature 1.
316401013410	threonine/serine transporter TdcC; Provisional; Region: PRK13629
316401013411	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
316401013412	11 probable transmembrane helices predicted for ETEC3384 by TMHMM2.0 at aa 23-40, 44-66, 97-119, 134-156, 163-185, 212-234, 255-277, 311-333, 358-380, 390-409 and 422-440
316401013413	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
316401013414	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
316401013415	tetramer interface [polypeptide binding]; other site
316401013416	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316401013417	catalytic residue [active]
316401013418	PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site.
316401013419	DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341
316401013420	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401013421	The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418
316401013422	putative substrate binding pocket [chemical binding]; other site
316401013423	putative dimerization interface [polypeptide binding]; other site
316401013424	PS00044 Bacterial regulatory proteins, lysR family signature.
316401013425	DNA-binding transcriptional activator TdcR; Provisional; Region: PRK11424
316401013426	PS00070 Aldehyde dehydrogenases cysteine active site.
316401013427	hypothetical protein; Provisional; Region: PRK09716
316401013428	glycerate kinase I; Provisional; Region: PRK10342
316401013429	PS00017 ATP/GTP-binding site motif A (P-loop).
316401013430	tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559
316401013431	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
316401013432	PS00895 3-hydroxyisobutyrate dehydrogenase signature.
316401013433	alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558
316401013434	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401013435	D-galactonate transporter; Region: 2A0114; TIGR00893
316401013436	putative substrate translocation pore; other site
316401013437	11 probable transmembrane helices predicted for ETEC3393 by TMHMM2.0 at aa 15-32, 53-75, 90-112, 151-173, 177-199, 251-273, 288-310, 317-339, 349-371, 380-402 and 412-434
316401013438	galactarate dehydratase; Region: galactar-dH20; TIGR03248
316401013439	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
316401013440	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
316401013441	PS00430 TonB-dependent receptor proteins signature 1.
316401013442	putative regulator PrlF; Provisional; Region: PRK09974
316401013443	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
316401013444	Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663
316401013445	DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802
316401013446	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
316401013447	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
316401013448	PS00141 Eukaryotic and viral aspartyl proteases active site.
316401013449	PS00894 Bacterial regulatory proteins, deoR family signature.
316401013450	tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458
316401013451	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
316401013452	active site
316401013453	phosphorylation site [posttranslational modification]
316401013454	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
316401013455	6 probable transmembrane helices predicted for ETEC3400 by TMHMM2.0 at aa 5-27, 34-56, 98-120, 141-163, 178-197 and 209-231
316401013456	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
316401013457	4 probable transmembrane helices predicted for ETEC3401 by TMHMM2.0 at aa 89-111, 161-183, 204-226 and 249-266
316401013458	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
316401013459	active pocket/dimerization site; other site
316401013460	active site
316401013461	phosphorylation site [posttranslational modification]
316401013462	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
316401013463	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
316401013464	active site
316401013465	dimer interface [polypeptide binding]; other site
316401013466	putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815
316401013467	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
316401013468	dimer interface [polypeptide binding]; other site
316401013469	active site
316401013470	AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010
316401013471	putative active site [active]
316401013472	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cd00453
316401013473	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
316401013474	active site
316401013475	intersubunit interface [polypeptide binding]; other site
316401013476	zinc binding site [ion binding]; other site
316401013477	Na+ binding site [ion binding]; other site
316401013478	PS00602 Fructose-bisphosphate aldolase class-II signature 1.
316401013479	PS00806 Fructose-bisphosphate aldolase class-II signature 2.
316401013480	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
316401013481	active site
316401013482	phosphorylation site [posttranslational modification]
316401013483	PTS system N-acetylgalactosamine-specific transporter subunit IIC; Provisional; Region: PRK09757
316401013484	6 probable transmembrane helices predicted for ETEC3406 by TMHMM2.0 at aa 4-21, 28-50, 96-118, 139-161, 176-198 and 210-232
316401013485	PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855
316401013486	5 probable transmembrane helices predicted for ETEC3407 by TMHMM2.0 at aa 98-120, 135-157, 177-199, 219-236 and 243-262
316401013487	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
316401013488	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
316401013489	active site
316401013490	trimer interface [polypeptide binding]; other site
316401013491	allosteric site; other site
316401013492	active site lid [active]
316401013493	PS01161 Glucosamine/galactosamine-6-phosphate isomerases signature.
316401013494	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
316401013495	Signal peptide predicted for ETEC3409 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.995 between residues 22 and 23
316401013496	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
316401013497	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
316401013498	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
316401013499	Signal peptide predicted for ETEC3410 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 23 and 24
316401013500	1 probable transmembrane helix predicted for ETEC3410 by TMHMM2.0 at aa 7-29
316401013501	PS00635 Gram-negative pili assembly chaperone signature.
316401013502	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
316401013503	PapC N-terminal domain; Region: PapC_N; pfam13954
316401013504	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
316401013505	PapC C-terminal domain; Region: PapC_C; pfam13953
316401013506	Signal peptide predicted for ETEC3411 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.999 between residues 40 and 41
316401013507	PS01151 Fimbrial biogenesis outer membrane usher protein signature.
316401013508	Fimbrial protein; Region: Fimbrial; pfam00419
316401013509	Signal peptide predicted for ETEC3412 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.822 between residues 20 and 21
316401013510	SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994
316401013511	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
316401013512	putative SAM binding site [chemical binding]; other site
316401013513	putative homodimer interface [polypeptide binding]; other site
316401013514	PS01296 Uncharacterized protein family UPF0011 signature.
316401013515	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
316401013516	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
316401013517	putative ligand binding site [chemical binding]; other site
316401013518	Signal peptide predicted for ETEC3414 by SignalP 2.0 HMM (Signal peptide probability 0.626) with cleavage site probability 0.430 between residues 29 and 30
316401013519	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401013520	PS00017 ATP/GTP-binding site motif A (P-loop).
316401013521	TIGR00252 family protein; Region: TIGR00252
316401013522	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
316401013523	dimer interface [polypeptide binding]; other site
316401013524	active site
316401013525	outer membrane lipoprotein; Provisional; Region: PRK11023
316401013526	BON domain; Region: BON; pfam04972
316401013527	BON domain; Region: BON; pfam04972
316401013528	Signal peptide predicted for ETEC3417 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.527 between residues 22 and 23
316401013529	1 probable transmembrane helix predicted for ETEC3417 by TMHMM2.0 at aa 7-29
316401013530	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401013531	Predicted permease; Region: DUF318; pfam03773
316401013532	9 probable transmembrane helices predicted for ETEC3418 by TMHMM2.0 at aa 15-32, 74-96, 111-133, 146-168, 172-191, 226-248, 263-285, 292-314 and 324-345
316401013533	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
316401013534	NADH(P)-binding; Region: NAD_binding_10; pfam13460
316401013535	NAD binding site [chemical binding]; other site
316401013536	active site
316401013537	intracellular protease, PfpI family; Region: PfpI; TIGR01382
316401013538	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
316401013539	proposed catalytic triad [active]
316401013540	conserved cys residue [active]
316401013541	hypothetical protein; Provisional; Region: PRK03467
316401013542	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
316401013543	GIY-YIG motif/motif A; other site
316401013544	putative active site [active]
316401013545	putative metal binding site [ion binding]; other site
316401013546	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
316401013547	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
316401013548	Coenzyme A binding pocket [chemical binding]; other site
316401013549	Putative lipid carrier protein [Lipid metabolism]; Region: COG3154
316401013550	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
316401013551	Peptidase family U32; Region: Peptidase_U32; pfam01136
316401013552	PS01276 Peptidase family U32 signature.
316401013553	putative protease; Provisional; Region: PRK15447
316401013554	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
316401013555	hypothetical protein; Provisional; Region: PRK10508
316401013556	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
316401013557	tryptophan permease; Provisional; Region: PRK10483
316401013558	aromatic amino acid transport protein; Region: araaP; TIGR00837
316401013559	11 probable transmembrane helices predicted for ETEC3428 by TMHMM2.0 at aa 13-35, 39-61, 87-109, 124-146, 153-175, 190-212, 225-247, 284-306, 318-340, 345-367 and 388-410
316401013560	PS00594 Aromatic amino acids permeases signature.
316401013561	ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634
316401013562	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
316401013563	ATP binding site [chemical binding]; other site
316401013564	Mg++ binding site [ion binding]; other site
316401013565	motif III; other site
316401013566	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
316401013567	nucleotide binding region [chemical binding]; other site
316401013568	ATP-binding site [chemical binding]; other site
316401013569	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
316401013570	putative RNA binding site [nucleotide binding]; other site
316401013571	PS00039 DEAD-box subfamily ATP-dependent helicases signature.
316401013572	PS00017 ATP/GTP-binding site motif A (P-loop).
316401013573	lipoprotein NlpI; Provisional; Region: PRK11189
316401013574	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
316401013575	binding surface
316401013576	TPR motif; other site
316401013577	Signal peptide predicted for ETEC3430 by SignalP 2.0 HMM (Signal peptide probability 0.915) with cleavage site probability 0.875 between residues 22 and 23
316401013578	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401013579	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
316401013580	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
316401013581	RNase E interface [polypeptide binding]; other site
316401013582	trimer interface [polypeptide binding]; other site
316401013583	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
316401013584	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
316401013585	RNase E interface [polypeptide binding]; other site
316401013586	trimer interface [polypeptide binding]; other site
316401013587	active site
316401013588	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
316401013589	putative nucleic acid binding region [nucleotide binding]; other site
316401013590	G-X-X-G motif; other site
316401013591	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
316401013592	RNA binding site [nucleotide binding]; other site
316401013593	domain interface; other site
316401013594	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
316401013595	16S/18S rRNA binding site [nucleotide binding]; other site
316401013596	S13e-L30e interaction site [polypeptide binding]; other site
316401013597	25S rRNA binding site [nucleotide binding]; other site
316401013598	PS00362 Ribosomal protein S15 signature.
316401013599	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
316401013600	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
316401013601	RNA binding site [nucleotide binding]; other site
316401013602	active site
316401013603	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
316401013604	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
316401013605	PS01319 Ribosome-binding factor A signature.
316401013606	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
316401013607	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
316401013608	translation initiation factor IF-2; Region: IF-2; TIGR00487
316401013609	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
316401013610	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
316401013611	G1 box; other site
316401013612	putative GEF interaction site [polypeptide binding]; other site
316401013613	GTP/Mg2+ binding site [chemical binding]; other site
316401013614	Switch I region; other site
316401013615	G2 box; other site
316401013616	G3 box; other site
316401013617	Switch II region; other site
316401013618	G4 box; other site
316401013619	G5 box; other site
316401013620	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
316401013621	Translation-initiation factor 2; Region: IF-2; pfam11987
316401013622	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
316401013623	PS01176 Initiation factor 2 signature.
316401013624	PS00017 ATP/GTP-binding site motif A (P-loop).
316401013625	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
316401013626	NusA N-terminal domain; Region: NusA_N; pfam08529
316401013627	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
316401013628	RNA binding site [nucleotide binding]; other site
316401013629	homodimer interface [polypeptide binding]; other site
316401013630	NusA-like KH domain; Region: KH_5; pfam13184
316401013631	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
316401013632	G-X-X-G motif; other site
316401013633	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
316401013634	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
316401013635	ribosome maturation protein RimP; Reviewed; Region: PRK00092
316401013636	Sm and related proteins; Region: Sm_like; cl00259
316401013637	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
316401013638	putative oligomer interface [polypeptide binding]; other site
316401013639	putative RNA binding site [nucleotide binding]; other site
316401013640	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
316401013641	ANP binding site [chemical binding]; other site
316401013642	Substrate Binding Site II [chemical binding]; other site
316401013643	Substrate Binding Site I [chemical binding]; other site
316401013644	PS00564 Argininosuccinate synthase signature 1.
316401013645	PS00565 Argininosuccinate synthase signature 2.
316401013646	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
316401013647	Sulfatase; Region: Sulfatase; pfam00884
316401013648	5 probable transmembrane helices predicted for ETEC3439 by TMHMM2.0 at aa 13-32, 42-64, 77-99, 109-131 and 144-163
316401013649	Signal peptide predicted for ETEC3439 by SignalP 2.0 HMM (Signal peptide probability 0.941) with cleavage site probability 0.816 between residues 31 and 32
316401013650	Preprotein translocase SecG subunit; Region: SecG; pfam03840
316401013651	2 probable transmembrane helices predicted for ETEC3440 by TMHMM2.0 at aa 5-22 and 51-73
316401013652	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
316401013653	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
316401013654	active site
316401013655	substrate binding site [chemical binding]; other site
316401013656	metal binding site [ion binding]; metal-binding site
316401013657	PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature.
316401013658	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
316401013659	dihydropteroate synthase; Region: DHPS; TIGR01496
316401013660	substrate binding pocket [chemical binding]; other site
316401013661	dimer interface [polypeptide binding]; other site
316401013662	inhibitor binding site; inhibition site
316401013663	PS00793 Dihydropteroate synthase signature 2.
316401013664	PS00792 Dihydropteroate synthase signature 1.
316401013665	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
316401013666	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316401013667	Walker A motif; other site
316401013668	ATP binding site [chemical binding]; other site
316401013669	Walker B motif; other site
316401013670	arginine finger; other site
316401013671	Peptidase family M41; Region: Peptidase_M41; pfam01434
316401013672	PS00674 AAA-protein family signature.
316401013673	PS00017 ATP/GTP-binding site motif A (P-loop).
316401013674	PS00017 ATP/GTP-binding site motif A (P-loop).
316401013675	2 probable transmembrane helices predicted for ETEC3443 by TMHMM2.0 at aa 5-24 and 97-119
316401013676	Signal peptide predicted for ETEC3443 by SignalP 2.0 HMM (Signal peptide probability 0.701) with cleavage site probability 0.380 between residues 27 and 28
316401013677	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
316401013678	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316401013679	S-adenosylmethionine binding site [chemical binding]; other site
316401013680	RNA-binding protein YhbY; Provisional; Region: PRK10343
316401013681	PS01301 Uncharacterized protein family UPF0044 signature.
316401013682	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
316401013683	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
316401013684	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
316401013685	PS00830 Prokaryotic transcription elongation factors signature 2.
316401013686	PS00829 Prokaryotic transcription elongation factors signature 1.
316401013687	D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113
316401013688	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
316401013689	Signal peptide predicted for ETEC3447 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.988 between residues 20 and 21
316401013690	GTPase CgtA; Reviewed; Region: obgE; PRK12298
316401013691	GTP1/OBG; Region: GTP1_OBG; pfam01018
316401013692	Obg GTPase; Region: Obg; cd01898
316401013693	G1 box; other site
316401013694	GTP/Mg2+ binding site [chemical binding]; other site
316401013695	Switch I region; other site
316401013696	G2 box; other site
316401013697	G3 box; other site
316401013698	Switch II region; other site
316401013699	G4 box; other site
316401013700	G5 box; other site
316401013701	PS00905 GTP1/OBG family signature.
316401013702	PS00017 ATP/GTP-binding site motif A (P-loop).
316401013703	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
316401013704	EamA-like transporter family; Region: EamA; pfam00892
316401013705	EamA-like transporter family; Region: EamA; pfam00892
316401013706	10 probable transmembrane helices predicted for ETEC3449 by TMHMM2.0 at aa 7-26, 36-58, 71-93, 103-120, 129-151, 155-177, 190-212, 217-239, 246-268 and 278-300
316401013707	Signal peptide predicted for ETEC3449 by SignalP 2.0 HMM (Signal peptide probability 0.971) with cleavage site probability 0.914 between residues 20 and 21
316401013708	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
316401013709	PS00831 Ribosomal protein L27 signature.
316401013710	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
316401013711	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
316401013712	PS01169 Ribosomal protein L21 signature.
316401013713	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
316401013714	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
316401013715	substrate binding pocket [chemical binding]; other site
316401013716	chain length determination region; other site
316401013717	substrate-Mg2+ binding site; other site
316401013718	catalytic residues [active]
316401013719	aspartate-rich region 1; other site
316401013720	active site lid residues [active]
316401013721	aspartate-rich region 2; other site
316401013722	PS00723 Polyprenyl synthetases signature 1.
316401013723	PS00444 Polyprenyl synthetases signature 2.
316401013724	DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344
316401013725	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
316401013726	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
316401013727	hinge; other site
316401013728	active site
316401013729	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
316401013730	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
316401013731	anti sigma factor interaction site; other site
316401013732	regulatory phosphorylation site [posttranslational modification]; other site
316401013733	ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117
316401013734	Signal peptide predicted for ETEC3457 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.910 between residues 21 and 22
316401013735	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
316401013736	mce related protein; Region: MCE; pfam02470
316401013737	Signal peptide predicted for ETEC3458 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.838 between residues 28 and 29
316401013738	1 probable transmembrane helix predicted for ETEC3458 by TMHMM2.0 at aa 7-26
316401013739	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
316401013740	conserved hypothetical integral membrane protein; Region: TIGR00056
316401013741	5 probable transmembrane helices predicted for ETEC3459 by TMHMM2.0 at aa 48-70, 85-107, 148-170, 197-219 and 239-258
316401013742	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
316401013743	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
316401013744	Walker A/P-loop; other site
316401013745	ATP binding site [chemical binding]; other site
316401013746	Q-loop/lid; other site
316401013747	ABC transporter signature motif; other site
316401013748	Walker B; other site
316401013749	D-loop; other site
316401013750	H-loop/switch region; other site
316401013751	PS00211 ABC transporters family signature.
316401013752	PS00017 ATP/GTP-binding site motif A (P-loop).
316401013753	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
316401013754	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
316401013755	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
316401013756	Signal peptide predicted for ETEC3461 by SignalP 2.0 HMM (Signal peptide probability 0.874) with cleavage site probability 0.621 between residues 18 and 19
316401013757	9 probable transmembrane helices predicted for ETEC3461 by TMHMM2.0 at aa 7-29, 39-61, 68-90, 129-146, 172-194, 204-226, 239-261, 276-293 and 300-322
316401013758	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
316401013759	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
316401013760	putative active site [active]
316401013761	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
316401013762	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401013763	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484
316401013764	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
316401013765	Signal peptide predicted for ETEC3463 by SignalP 2.0 HMM (Signal peptide probability 0.886) with cleavage site probability 0.843 between residues 17 and 18
316401013766	lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893
316401013767	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
316401013768	Signal peptide predicted for ETEC3464 by SignalP 2.0 HMM (Signal peptide probability 0.992) with cleavage site probability 0.749 between residues 25 and 26
316401013769	1 probable transmembrane helix predicted for ETEC3464 by TMHMM2.0 at aa 7-25
316401013770	lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894
316401013771	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
316401013772	Signal peptide predicted for ETEC3465 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.981 between residues 27 and 28
316401013773	lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895
316401013774	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
316401013775	Walker A/P-loop; other site
316401013776	ATP binding site [chemical binding]; other site
316401013777	Q-loop/lid; other site
316401013778	ABC transporter signature motif; other site
316401013779	Walker B; other site
316401013780	D-loop; other site
316401013781	H-loop/switch region; other site
316401013782	PS00017 ATP/GTP-binding site motif A (P-loop).
316401013783	PS00211 ABC transporters family signature.
316401013784	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
316401013785	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
316401013786	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
316401013787	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
316401013788	PS00717 Sigma-54 factors family signature 1.
316401013789	PS00718 Sigma-54 factors family signature 2.
316401013790	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
316401013791	30S subunit binding site; other site
316401013792	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
316401013793	active site
316401013794	phosphorylation site [posttranslational modification]
316401013795	PS00372 PTS EIIA domains phosphorylation site signature 2.
316401013796	P-loop ATPase protein family; Region: ATP_bind_2; pfam03668
316401013797	PS00017 ATP/GTP-binding site motif A (P-loop).
316401013798	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
316401013799	dimerization domain swap beta strand [polypeptide binding]; other site
316401013800	regulatory protein interface [polypeptide binding]; other site
316401013801	active site
316401013802	regulatory phosphorylation site [posttranslational modification]; other site
316401013803	PS00369 PTS HPR component histidine phosphorylation site signature.
316401013804	PS00589 PTS HPR component serine phosphorylation site signature.
316401013805	hypothetical protein; Provisional; Region: PRK10345
316401013806	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
316401013807	Transglycosylase; Region: Transgly; cl17702
316401013808	1 probable transmembrane helix predicted for ETEC3473 by TMHMM2.0 at aa 21-43
316401013809	Signal peptide predicted for ETEC3473 by SignalP 2.0 HMM (Signal peptide probability 0.953) with cleavage site probability 0.728 between residues 42 and 43
316401013810	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
316401013811	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
316401013812	conserved cys residue [active]
316401013813	aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091
316401013814	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316401013815	putative active site [active]
316401013816	heme pocket [chemical binding]; other site
316401013817	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316401013818	dimer interface [polypeptide binding]; other site
316401013819	phosphorylation site [posttranslational modification]
316401013820	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316401013821	ATP binding site [chemical binding]; other site
316401013822	Mg2+ binding site [ion binding]; other site
316401013823	G-X-G motif; other site
316401013824	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316401013825	active site
316401013826	phosphorylation site [posttranslational modification]
316401013827	intermolecular recognition site; other site
316401013828	dimerization interface [polypeptide binding]; other site
316401013829	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
316401013830	putative binding surface; other site
316401013831	active site
316401013832	2 probable transmembrane helices predicted for ETEC3475 by TMHMM2.0 at aa 20-42 and 55-77
316401013833	Signal peptide predicted for ETEC3475 by SignalP 2.0 HMM (Signal peptide probability 0.898) with cleavage site probability 0.591 between residues 41 and 42
316401013834	radical SAM protein, TIGR01212 family; Region: TIGR01212
316401013835	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316401013836	FeS/SAM binding site; other site
316401013837	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
316401013838	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
316401013839	active site
316401013840	dimer interface [polypeptide binding]; other site
316401013841	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
316401013842	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
316401013843	active site
316401013844	FMN binding site [chemical binding]; other site
316401013845	substrate binding site [chemical binding]; other site
316401013846	3Fe-4S cluster binding site [ion binding]; other site
316401013847	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
316401013848	domain interface; other site
316401013849	PS00017 ATP/GTP-binding site motif A (P-loop).
316401013850	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
316401013851	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
316401013852	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
316401013853	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
316401013854	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
316401013855	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
316401013856	PS00017 ATP/GTP-binding site motif A (P-loop).
316401013857	IS1 transposase; Region: DDE_Tnp_IS1; pfam03400
316401013858	Similar to Escherichia coli. yhcg UniProt:P45423 (EMBL:U18997 (375 aa) fasta scores: E()=2.3e-101, 100.000% id in 247 aa
316401013859	uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022
316401013860	N-acetylmannosamine kinase; Provisional; Region: PRK05082
316401013861	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
316401013862	nucleotide binding site [chemical binding]; other site
316401013863	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
316401013864	PS01125 ROK family signature.
316401013865	Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010
316401013866	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
316401013867	putative active site cavity [active]
316401013868	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401013869	putative sialic acid transporter; Provisional; Region: PRK03893
316401013870	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401013871	putative substrate translocation pore; other site
316401013872	12 probable transmembrane helices predicted for ETEC3485 by TMHMM2.0 at aa 21-43, 53-72, 92-114, 146-168, 170-189, 224-241, 248-267, 277-299, 316-338, 353-375, 404-426 and 431-453
316401013873	PS00146 Beta-lactamase class-A active site.
316401013874	N-acetylneuraminate lyase; Region: nanA; TIGR00683
316401013875	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
316401013876	inhibitor site; inhibition site
316401013877	active site
316401013878	dimer interface [polypeptide binding]; other site
316401013879	catalytic residue [active]
316401013880	PS00666 Dihydrodipicolinate synthetase signature 2.
316401013881	PS00665 Dihydrodipicolinate synthetase signature 1.
316401013882	transcriptional regulator NanR; Provisional; Region: PRK03837
316401013883	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
316401013884	DNA-binding site [nucleotide binding]; DNA binding site
316401013885	FCD domain; Region: FCD; pfam07729
316401013886	PS00043 Bacterial regulatory proteins, gntR family signature.
316401013887	putative cryptic C4-dicarboxylate transporter DcuD; Provisional; Region: PRK09804
316401013888	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
316401013889	13 probable transmembrane helices predicted for ETEC3488 by TMHMM2.0 at aa 4-19, 26-48, 68-90, 110-132, 152-174, 193-215, 242-264, 271-290, 305-327, 348-370, 375-397, 409-431 and 435-454
316401013890	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
316401013891	stringent starvation protein A; Provisional; Region: sspA; PRK09481
316401013892	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
316401013893	C-terminal domain interface [polypeptide binding]; other site
316401013894	putative GSH binding site (G-site) [chemical binding]; other site
316401013895	dimer interface [polypeptide binding]; other site
316401013896	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
316401013897	dimer interface [polypeptide binding]; other site
316401013898	N-terminal domain interface [polypeptide binding]; other site
316401013899	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
316401013900	PS00360 Ribosomal protein S9 signature.
316401013901	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
316401013902	23S rRNA interface [nucleotide binding]; other site
316401013903	L3 interface [polypeptide binding]; other site
316401013904	PS00783 Ribosomal protein L13 signature.
316401013905	Predicted ATPase [General function prediction only]; Region: COG1485
316401013906	PS00017 ATP/GTP-binding site motif A (P-loop).
316401013907	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105
316401013908	hypothetical protein; Provisional; Region: PRK11677
316401013909	1 probable transmembrane helix predicted for ETEC3494 by TMHMM2.0 at aa 5-24
316401013910	serine endoprotease; Provisional; Region: PRK10139
316401013911	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
316401013912	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
316401013913	protein binding site [polypeptide binding]; other site
316401013914	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
316401013915	Signal peptide predicted for ETEC3495 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.992 between residues 27 and 28
316401013916	1 probable transmembrane helix predicted for ETEC3495 by TMHMM2.0 at aa 7-29
316401013917	serine endoprotease; Provisional; Region: PRK10898
316401013918	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
316401013919	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
316401013920	Signal peptide predicted for ETEC3496 by SignalP 2.0 HMM (Signal peptide probability 0.914) with cleavage site probability 0.525 between residues 28 and 29
316401013921	1 probable transmembrane helix predicted for ETEC3496 by TMHMM2.0 at aa 5-27
316401013922	malate dehydrogenase; Provisional; Region: PRK05086
316401013923	Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337
316401013924	NAD binding site [chemical binding]; other site
316401013925	dimerization interface [polypeptide binding]; other site
316401013926	Substrate binding site [chemical binding]; other site
316401013927	PS00068 Malate dehydrogenase active site signature.
316401013928	arginine repressor; Provisional; Region: PRK05066
316401013929	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
316401013930	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
316401013931	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
316401013932	Signal peptide predicted for ETEC3499 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 22 and 23
316401013933	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142
316401013934	RNAase interaction site [polypeptide binding]; other site
316401013935	p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631
316401013936	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
316401013937	10 probable transmembrane helices predicted for ETEC3501 by TMHMM2.0 at aa 13-33, 38-60, 67-89, 93-112, 119-136, 151-168, 366-388, 403-425, 432-449 and 481-503
316401013938	Signal peptide predicted for ETEC3501 by SignalP 2.0 HMM (Signal peptide probability 0.634) with cleavage site probability 0.628 between residues 53 and 54
316401013939	p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559
316401013940	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
316401013941	HlyD family secretion protein; Region: HlyD_3; pfam13437
316401013942	1 probable transmembrane helix predicted for ETEC3502 by TMHMM2.0 at aa 13-32
316401013943	Signal peptide predicted for ETEC3502 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.816 between residues 30 and 31
316401013944	efflux system membrane protein; Provisional; Region: PRK11594
316401013945	2 probable transmembrane helices predicted for ETEC3503 by TMHMM2.0 at aa 7-29 and 44-66
316401013946	transcriptional regulator; Provisional; Region: PRK10632
316401013947	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401013948	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
316401013949	putative effector binding pocket; other site
316401013950	dimerization interface [polypeptide binding]; other site
316401013951	PS00044 Bacterial regulatory proteins, lysR family signature.
316401013952	protease TldD; Provisional; Region: tldD; PRK10735
316401013953	hypothetical protein; Provisional; Region: PRK10899
316401013954	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
316401013955	1 probable transmembrane helix predicted for ETEC3506 by TMHMM2.0 at aa 7-29
316401013956	Signal peptide predicted for ETEC3506 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.786 between residues 19 and 20
316401013957	ribonuclease G; Provisional; Region: PRK11712
316401013958	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
316401013959	homodimer interface [polypeptide binding]; other site
316401013960	oligonucleotide binding site [chemical binding]; other site
316401013961	Maf-like protein; Region: Maf; pfam02545
316401013962	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
316401013963	active site
316401013964	dimer interface [polypeptide binding]; other site
316401013965	rod shape-determining protein MreD; Provisional; Region: PRK11060
316401013966	5 probable transmembrane helices predicted for ETEC3509 by TMHMM2.0 at aa 10-24, 31-53, 68-90, 97-119 and 134-151
316401013967	rod shape-determining protein MreC; Region: mreC; TIGR00219
316401013968	rod shape-determining protein MreC; Region: MreC; pfam04085
316401013969	1 probable transmembrane helix predicted for ETEC3510 by TMHMM2.0 at aa 13-35
316401013970	rod shape-determining protein MreB; Provisional; Region: PRK13927
316401013971	MreB and similar proteins; Region: MreB_like; cd10225
316401013972	nucleotide binding site [chemical binding]; other site
316401013973	Mg binding site [ion binding]; other site
316401013974	putative protofilament interaction site [polypeptide binding]; other site
316401013975	RodZ interaction site [polypeptide binding]; other site
316401013976	regulatory protein CsrD; Provisional; Region: PRK11059
316401013977	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316401013978	metal binding site [ion binding]; metal-binding site
316401013979	active site
316401013980	I-site; other site
316401013981	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
316401013982	2 probable transmembrane helices predicted for ETEC3512 by TMHMM2.0 at aa 10-32 and 130-152
316401013983	Signal peptide predicted for ETEC3512 by SignalP 2.0 HMM (Signal peptide probability 0.974) with cleavage site probability 0.586 between residues 25 and 26
316401013984	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
316401013985	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
316401013986	NADP binding site [chemical binding]; other site
316401013987	dimer interface [polypeptide binding]; other site
316401013988	PS00213 Lipocalin signature.
316401013989	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
316401013990	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
316401013991	carboxyltransferase (CT) interaction site; other site
316401013992	biotinylation site [posttranslational modification]; other site
316401013993	PS00188 Biotin-requiring enzymes attachment site.
316401013994	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
316401013995	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
316401013996	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
316401013997	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
316401013998	PS00866 Carbamoyl-phosphate synthase subdomain signature 1.
316401013999	PS00867 Carbamoyl-phosphate synthase subdomain signature 2.
316401014000	hypothetical protein; Provisional; Region: PRK10633
316401014001	2 probable transmembrane helices predicted for ETEC3516 by TMHMM2.0 at aa 13-35 and 45-64
316401014002	Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327
316401014003	Na binding site [ion binding]; other site
316401014004	13 probable transmembrane helices predicted for ETEC3517 by TMHMM2.0 at aa 5-24, 37-59, 72-94, 123-145, 160-182, 189-211, 233-255, 268-290, 319-341, 369-386, 391-413, 425-447 and 452-471
316401014005	PS00456 Sodium:solute symporter family signature 1.
316401014006	PS00457 Sodium:solute symporter family signature 2.
316401014007	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
316401014008	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
316401014009	tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415
316401014010	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
316401014011	FMN binding site [chemical binding]; other site
316401014012	active site
316401014013	catalytic residues [active]
316401014014	substrate binding site [chemical binding]; other site
316401014015	PS01136 Uncharacterized protein family UPF0034 signature.
316401014016	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
316401014017	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
316401014018	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
316401014019	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316401014020	DNA methylase; Region: N6_N4_Mtase; pfam01555
316401014021	PS00092 N-6 Adenine-specific DNA methylases signature.
316401014022	Protein of unknown function (DUF2556); Region: DUF2556; pfam10831
316401014023	1 probable transmembrane helix predicted for ETEC3522 by TMHMM2.0 at aa 7-29
316401014024	DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975
316401014025	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
316401014026	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
316401014027	PS01081 Bacterial regulatory proteins, tetR family signature.
316401014028	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
316401014029	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
316401014030	HlyD family secretion protein; Region: HlyD_3; pfam13437
316401014031	Signal peptide predicted for ETEC3524 by SignalP 2.0 HMM (Signal peptide probability 0.912) with cleavage site probability 0.754 between residues 22 and 23
316401014032	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401014033	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
316401014034	Protein export membrane protein; Region: SecD_SecF; cl14618
316401014035	Signal peptide predicted for ETEC3525 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.779 between residues 26 and 27
316401014036	12 probable transmembrane helices predicted for ETEC3525 by TMHMM2.0 at aa 11-33, 337-359, 366-388, 392-414, 438-460, 470-492, 540-562, 869-891, 896-918, 923-945, 974-996 and 1006-1028
316401014037	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
316401014038	Signal peptide predicted for ETEC3526 by SignalP 2.0 HMM (Signal peptide probability 0.958) with cleavage site probability 0.957 between residues 18 and 19
316401014039	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401014040	1 probable transmembrane helix predicted for ETEC3526 by TMHMM2.0 at aa 50-72
316401014041	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
316401014042	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
316401014043	substrate binding pocket [chemical binding]; other site
316401014044	membrane-bound complex binding site; other site
316401014045	hinge residues; other site
316401014046	PS01039 Bacterial extracellular solute-binding proteins, family 3 signature.
316401014047	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
316401014048	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401014049	conserved gate region; other site
316401014050	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401014051	dimer interface [polypeptide binding]; other site
316401014052	conserved gate region; other site
316401014053	putative PBP binding loops; other site
316401014054	ABC-ATPase subunit interface; other site
316401014055	8 probable transmembrane helices predicted for ETEC3528 by TMHMM2.0 at aa 21-40, 83-105, 126-148, 181-203, 216-235, 255-277, 333-352 and 362-384
316401014056	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
316401014057	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
316401014058	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401014059	dimer interface [polypeptide binding]; other site
316401014060	conserved gate region; other site
316401014061	putative PBP binding loops; other site
316401014062	ABC-ATPase subunit interface; other site
316401014063	8 probable transmembrane helices predicted for ETEC3529 by TMHMM2.0 at aa 28-50, 97-119, 126-148, 158-180, 201-223, 278-300, 305-323 and 327-349
316401014064	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401014065	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
316401014066	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
316401014067	Walker A/P-loop; other site
316401014068	ATP binding site [chemical binding]; other site
316401014069	Q-loop/lid; other site
316401014070	ABC transporter signature motif; other site
316401014071	Walker B; other site
316401014072	D-loop; other site
316401014073	H-loop/switch region; other site
316401014074	PS00017 ATP/GTP-binding site motif A (P-loop).
316401014075	PS00211 ABC transporters family signature.
316401014076	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
316401014077	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
316401014078	trimer interface [polypeptide binding]; other site
316401014079	putative metal binding site [ion binding]; other site
316401014080	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
316401014081	shikimate 5-dehydrogenase; Region: aroE; TIGR00507
316401014082	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
316401014083	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
316401014084	shikimate binding site; other site
316401014085	NAD(P) binding site [chemical binding]; other site
316401014086	tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634
316401014087	PS01147 SUA5/yciO/yrdC family signature.
316401014088	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
316401014089	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
316401014090	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
316401014091	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
316401014092	hypothetical protein; Validated; Region: PRK03430
316401014093	hypothetical protein; Provisional; Region: PRK10736
316401014094	DNA protecting protein DprA; Region: dprA; TIGR00732
316401014095	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
316401014096	active site
316401014097	catalytic residues [active]
316401014098	metal binding site [ion binding]; metal-binding site
316401014099	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
316401014100	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
316401014101	putative active site [active]
316401014102	substrate binding site [chemical binding]; other site
316401014103	putative cosubstrate binding site; other site
316401014104	catalytic site [active]
316401014105	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
316401014106	substrate binding site [chemical binding]; other site
316401014107	PS00373 Phosphoribosylglycinamide formyltransferase active site.
316401014108	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
316401014109	putative RNA binding site [nucleotide binding]; other site
316401014110	16S rRNA methyltransferase B; Provisional; Region: PRK10901
316401014111	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316401014112	S-adenosylmethionine binding site [chemical binding]; other site
316401014113	PS01153 NOL1/NOP2/sun family signature.
316401014114	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
316401014115	TrkA-N domain; Region: TrkA_N; pfam02254
316401014116	TrkA-C domain; Region: TrkA_C; pfam02080
316401014117	TrkA-N domain; Region: TrkA_N; pfam02254
316401014118	TrkA-C domain; Region: TrkA_C; pfam02080
316401014119	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
316401014120	Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741
316401014121	PS01327 Large-conductance mechanosensitive channels mscL family signature.
316401014122	2 probable transmembrane helices predicted for ETEC3542 by TMHMM2.0 at aa 20-42 and 77-99
316401014123	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036
316401014124	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
316401014125	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
316401014126	DNA binding residues [nucleotide binding]
316401014127	dimer interface [polypeptide binding]; other site
316401014128	metal binding site [ion binding]; metal-binding site
316401014129	PS00552 Bacterial regulatory proteins, merR family signature.
316401014130	hypothetical protein; Provisional; Region: PRK10203
316401014131	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
316401014132	PS01167 Ribosomal protein L17 signature.
316401014133	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
316401014134	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
316401014135	alphaNTD homodimer interface [polypeptide binding]; other site
316401014136	alphaNTD - beta interaction site [polypeptide binding]; other site
316401014137	alphaNTD - beta' interaction site [polypeptide binding]; other site
316401014138	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
316401014139	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
316401014140	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
316401014141	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
316401014142	RNA binding surface [nucleotide binding]; other site
316401014143	PS00632 Ribosomal protein S4 signature.
316401014144	30S ribosomal protein S11; Validated; Region: PRK05309
316401014145	PS00054 Ribosomal protein S11 signature.
316401014146	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
316401014147	30S ribosomal protein S13; Region: bact_S13; TIGR03631
316401014148	PS00646 Ribosomal protein S13 signature.
316401014149	PS00061 Short-chain dehydrogenases/reductases family signature.
316401014150	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
316401014151	PS00828 Ribosomal protein L36 signature.
316401014152	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
316401014153	SecY translocase; Region: SecY; pfam00344
316401014154	10 probable transmembrane helices predicted for ETEC3552 by TMHMM2.0 at aa 22-44, 76-98, 119-138, 153-175, 182-204, 215-237, 274-296, 316-338, 373-392 and 397-414
316401014155	PS00095 C-5 cytosine-specific DNA methylases C-terminal signature.
316401014156	PS00756 Protein secY signature 2.
316401014157	PS00755 Protein secY signature 1.
316401014158	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
316401014159	PS00475 Ribosomal protein L15 signature.
316401014160	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
316401014161	23S rRNA binding site [nucleotide binding]; other site
316401014162	PS00634 Ribosomal protein L30 signature.
316401014163	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
316401014164	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
316401014165	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
316401014166	PS00585 Ribosomal protein S5 signature.
316401014167	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
316401014168	23S rRNA interface [nucleotide binding]; other site
316401014169	5S rRNA interface [nucleotide binding]; other site
316401014170	L27 interface [polypeptide binding]; other site
316401014171	L5 interface [polypeptide binding]; other site
316401014172	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
316401014173	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
316401014174	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
316401014175	PS00525 Ribosomal protein L6 signature 1.
316401014176	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
316401014177	PS00294 Prenyl group binding site (CAAX box).
316401014178	PS00053 Ribosomal protein S8 signature.
316401014179	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
316401014180	PS00527 Ribosomal protein S14 signature.
316401014181	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
316401014182	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
316401014183	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
316401014184	PS00358 Ribosomal protein L5 signature.
316401014185	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
316401014186	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
316401014187	RNA binding site [nucleotide binding]; other site
316401014188	PS01108 Ribosomal protein L24 signature.
316401014189	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
316401014190	PS00049 Ribosomal protein L14 signature.
316401014191	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
316401014192	PS00056 Ribosomal protein S17 signature.
316401014193	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
316401014194	23S rRNA interface [nucleotide binding]; other site
316401014195	putative translocon interaction site; other site
316401014196	signal recognition particle (SRP54) interaction site; other site
316401014197	L23 interface [polypeptide binding]; other site
316401014198	trigger factor interaction site; other site
316401014199	PS00579 Ribosomal protein L29 signature.
316401014200	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
316401014201	23S rRNA interface [nucleotide binding]; other site
316401014202	5S rRNA interface [nucleotide binding]; other site
316401014203	putative antibiotic binding site [chemical binding]; other site
316401014204	L25 interface [polypeptide binding]; other site
316401014205	L27 interface [polypeptide binding]; other site
316401014206	PS00701 Ribosomal protein L16 signature 2.
316401014207	PS00586 Ribosomal protein L16 signature 1.
316401014208	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
316401014209	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
316401014210	G-X-X-G motif; other site
316401014211	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
316401014212	PS00548 Ribosomal protein S3 signature.
316401014213	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
316401014214	protein-rRNA interface [nucleotide binding]; other site
316401014215	putative translocon binding site; other site
316401014216	PS00464 Ribosomal protein L22 signature.
316401014217	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
316401014218	PS00323 Ribosomal protein S19 signature.
316401014219	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
316401014220	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
316401014221	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
316401014222	PS00467 Ribosomal protein L2 signature.
316401014223	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
316401014224	PS00050 Ribosomal protein L23 signature.
316401014225	PS00430 TonB-dependent receptor proteins signature 1.
316401014226	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
316401014227	50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625
316401014228	PS00474 Ribosomal protein L3 signature.
316401014229	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
316401014230	PS00361 Ribosomal protein S10 signature.
316401014231	protein secretion protein GspB; Provisional; Region: PRK09697
316401014232	1 probable transmembrane helix predicted for ETEC3574 by TMHMM2.0 at aa 28-50
316401014233	AAA domain; Region: AAA_22; pfam13401
316401014234	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
316401014235	1 probable transmembrane helix predicted for ETEC3575 by TMHMM2.0 at aa 239-261
316401014236	PS00017 ATP/GTP-binding site motif A (P-loop).
316401014237	Type II secretory pathway, component PulC [Intracellular trafficking and secretion]; Region: PulC; COG3031
316401014238	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
316401014239	1 probable transmembrane helix predicted for ETEC3576 by TMHMM2.0 at aa 21-43
316401014240	PS01141 Bacterial type II secretion system protein C signature.
316401014241	type II secretion system protein D; Region: type_II_gspD; TIGR02517
316401014242	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
316401014243	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
316401014244	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
316401014245	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
316401014246	Signal peptide predicted for ETEC3577 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 23 and 24
316401014247	PS00875 Bacterial type II secretion system protein D signature.
316401014248	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
316401014249	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
316401014250	Walker A motif; other site
316401014251	ATP binding site [chemical binding]; other site
316401014252	Walker B motif; other site
316401014253	PS00017 ATP/GTP-binding site motif A (P-loop).
316401014254	PS00662 Bacterial type II secretion system protein E signature.
316401014255	type II secretion system protein F; Region: GspF; TIGR02120
316401014256	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
316401014257	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
316401014258	PS00874 Bacterial type II secretion system protein F signature.
316401014259	3 probable transmembrane helices predicted for ETEC3579 by TMHMM2.0 at aa 97-119, 150-169 and 297-319
316401014260	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
316401014261	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
316401014262	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
316401014263	PS00409 Prokaryotic N-terminal methylation site.
316401014264	1 probable transmembrane helix predicted for ETEC3580 by TMHMM2.0 at aa 10-32
316401014265	Signal peptide predicted for ETEC3581 by SignalP 2.0 HMM (Signal peptide probability 0.637) with cleavage site probability 0.279 between residues 29 and 30
316401014266	PS00409 Prokaryotic N-terminal methylation site.
316401014267	1 probable transmembrane helix predicted for ETEC3581 by TMHMM2.0 at aa 7-29
316401014268	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
316401014269	type II secretion system protein I; Region: gspI; TIGR01707
316401014270	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
316401014271	Signal peptide predicted for ETEC3582 by SignalP 2.0 HMM (Signal peptide probability 0.888) with cleavage site probability 0.326 between residues 23 and 24
316401014272	PS00409 Prokaryotic N-terminal methylation site.
316401014273	1 probable transmembrane helix predicted for ETEC3582 by TMHMM2.0 at aa 10-32
316401014274	Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795
316401014275	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
316401014276	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
316401014277	Signal peptide predicted for ETEC3583 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.979 between residues 34 and 35
316401014278	PS00409 Prokaryotic N-terminal methylation site.
316401014279	1 probable transmembrane helix predicted for ETEC3583 by TMHMM2.0 at aa 7-29
316401014280	Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156
316401014281	Signal peptide predicted for ETEC3584 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.987 between residues 24 and 25
316401014282	1 probable transmembrane helix predicted for ETEC3584 by TMHMM2.0 at aa 7-29
316401014283	Type II secretory pathway, component PulL [Intracellular trafficking and secretion]; Region: PulL; COG3297
316401014284	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
316401014285	GspL periplasmic domain; Region: GspL_C; pfam12693
316401014286	Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612
316401014287	1 probable transmembrane helix predicted for ETEC3586 by TMHMM2.0 at aa 15-34
316401014288	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
316401014289	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
316401014290	Signal peptide predicted for ETEC3587 by SignalP 2.0 HMM (Signal peptide probability 0.647) with cleavage site probability 0.562 between residues 23 and 24
316401014291	7 probable transmembrane helices predicted for ETEC3587 by TMHMM2.0 at aa 7-29, 49-71, 78-100, 104-122, 127-149, 169-191 and 204-223
316401014292	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
316401014293	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
316401014294	heme binding site [chemical binding]; other site
316401014295	ferroxidase pore; other site
316401014296	ferroxidase diiron center [ion binding]; other site
316401014297	PS00549 Bacterioferritin signature.
316401014298	bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509
316401014299	Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046
316401014300	Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046
316401014301	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
316401014302	aromatic chitin/cellulose binding site residues [chemical binding]; other site
316401014303	PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain.  Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543
316401014304	active site
316401014305	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401014306	Signal peptide predicted for ETEC3590 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.976 between residues 24 and 25
316401014307	elongation factor Tu; Reviewed; Region: PRK00049
316401014308	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
316401014309	G1 box; other site
316401014310	GEF interaction site [polypeptide binding]; other site
316401014311	GTP/Mg2+ binding site [chemical binding]; other site
316401014312	Switch I region; other site
316401014313	G2 box; other site
316401014314	G3 box; other site
316401014315	Switch II region; other site
316401014316	G4 box; other site
316401014317	G5 box; other site
316401014318	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
316401014319	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
316401014320	Antibiotic Binding Site [chemical binding]; other site
316401014321	PS00301 GTP-binding elongation factors signature.
316401014322	PS00017 ATP/GTP-binding site motif A (P-loop).
316401014323	elongation factor G; Reviewed; Region: PRK00007
316401014324	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
316401014325	G1 box; other site
316401014326	putative GEF interaction site [polypeptide binding]; other site
316401014327	GTP/Mg2+ binding site [chemical binding]; other site
316401014328	Switch I region; other site
316401014329	G2 box; other site
316401014330	G3 box; other site
316401014331	Switch II region; other site
316401014332	G4 box; other site
316401014333	G5 box; other site
316401014334	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
316401014335	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
316401014336	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
316401014337	PS00301 GTP-binding elongation factors signature.
316401014338	PS00017 ATP/GTP-binding site motif A (P-loop).
316401014339	30S ribosomal protein S7; Validated; Region: PRK05302
316401014340	PS00052 Ribosomal protein S7 signature.
316401014341	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
316401014342	S17 interaction site [polypeptide binding]; other site
316401014343	S8 interaction site; other site
316401014344	16S rRNA interaction site [nucleotide binding]; other site
316401014345	streptomycin interaction site [chemical binding]; other site
316401014346	23S rRNA interaction site [nucleotide binding]; other site
316401014347	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
316401014348	PS00055 Ribosomal protein S12 signature.
316401014349	sulfur transfer complex subunit TusB; Provisional; Region: PRK13510
316401014350	sulfur relay protein TusC; Validated; Region: PRK00211
316401014351	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
316401014352	YheO-like PAS domain; Region: PAS_6; pfam08348
316401014353	HTH domain; Region: HTH_22; pfam13309
316401014354	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902
316401014355	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
316401014356	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
316401014357	PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2.
316401014358	Signal peptide predicted for ETEC3597 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.977 between residues 25 and 26
316401014359	phi X174 lysis protein; Provisional; Region: PRK02793
316401014360	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
316401014361	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
316401014362	PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2.
316401014363	PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1.
316401014364	Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529
316401014365	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
316401014366	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
316401014367	TrkA-N domain; Region: TrkA_N; pfam02254
316401014368	13 probable transmembrane helices predicted for ETEC3601 by TMHMM2.0 at aa 5-24, 29-51, 56-73, 86-108, 113-135, 148-170, 180-197, 204-226, 230-252, 265-287, 291-313, 326-344 and 354-376
316401014369	Signal peptide predicted for ETEC3601 by SignalP 2.0 HMM (Signal peptide probability 0.947) with cleavage site probability 0.511 between residues 19 and 20
316401014370	glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930
316401014371	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
316401014372	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316401014373	Walker A/P-loop; other site
316401014374	ATP binding site [chemical binding]; other site
316401014375	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
316401014376	ABC transporter signature motif; other site
316401014377	Walker B; other site
316401014378	D-loop; other site
316401014379	ABC transporter; Region: ABC_tran_2; pfam12848
316401014380	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
316401014381	PS00017 ATP/GTP-binding site motif A (P-loop).
316401014382	PS00211 ABC transporters family signature.
316401014383	PS00017 ATP/GTP-binding site motif A (P-loop).
316401014384	PS00211 ABC transporters family signature.
316401014385	putative hydrolase; Provisional; Region: PRK10985
316401014386	PS01133 Uncharacterized protein family UPF0017 signature.
316401014387	hypothetical protein; Provisional; Region: PRK04966
316401014388	Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029
316401014389	active site
316401014390	Signal peptide predicted for ETEC3606 by SignalP 2.0 HMM (Signal peptide probability 0.637) with cleavage site probability 0.588 between residues 24 and 25
316401014391	PS00017 ATP/GTP-binding site motif A (P-loop).
316401014392	PS00567 Phosphoribulokinase signature.
316401014393	hypothetical protein; Provisional; Region: PRK10738
316401014394	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
316401014395	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
316401014396	ligand binding site [chemical binding]; other site
316401014397	flexible hinge region; other site
316401014398	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
316401014399	putative switch regulator; other site
316401014400	non-specific DNA interactions [nucleotide binding]; other site
316401014401	DNA binding site [nucleotide binding]
316401014402	sequence specific DNA binding site [nucleotide binding]; other site
316401014403	putative cAMP binding site [chemical binding]; other site
316401014404	PS00888 Cyclic nucleotide-binding domain signature 1.
316401014405	PS00889 Cyclic nucleotide-binding domain signature 2.
316401014406	PS00042 Bacterial regulatory proteins, crp family signature.
316401014407	integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667
316401014408	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
316401014409	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
316401014410	9 probable transmembrane helices predicted for ETEC3609 by TMHMM2.0 at aa 20-42, 63-85, 89-111, 116-133, 138-160, 416-435, 440-457, 462-481 and 491-510
316401014411	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
316401014412	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
316401014413	inhibitor-cofactor binding pocket; inhibition site
316401014414	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316401014415	catalytic residue [active]
316401014416	PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site.
316401014417	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
316401014418	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
316401014419	glutamine binding [chemical binding]; other site
316401014420	catalytic triad [active]
316401014421	PS00017 ATP/GTP-binding site motif A (P-loop).
316401014422	PS00442 Glutamine amidotransferases class-I active site.
316401014423	PS00678 Trp-Asp (WD) repeats signature.
316401014424	Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184
316401014425	cell filamentation protein Fic; Provisional; Region: PRK10347
316401014426	hypothetical protein; Provisional; Region: PRK10204
316401014427	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
316401014428	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
316401014429	substrate binding site [chemical binding]; other site
316401014430	PS00170 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature.
316401014431	Signal peptide predicted for ETEC3614 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 24 and 25
316401014432	putative transporter; Provisional; Region: PRK03699
316401014433	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401014434	putative substrate translocation pore; other site
316401014435	Signal peptide predicted for ETEC3615 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.983 between residues 32 and 33
316401014436	12 probable transmembrane helices predicted for ETEC3615 by TMHMM2.0 at aa 12-34, 49-66, 78-95, 99-121, 134-156, 161-183, 204-226, 246-268, 273-292, 296-318, 330-352 and 362-381
316401014437	PS00217 Sugar transport proteins signature 2.
316401014438	nitrite reductase subunit NirD; Provisional; Region: PRK14989
316401014439	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
316401014440	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
316401014441	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
316401014442	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
316401014443	PS00365 Nitrite and sulfite reductases iron-sulfur/siroheme-binding site.
316401014444	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
316401014445	PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide.
316401014446	nitrite transporter NirC; Provisional; Region: PRK11562
316401014447	6 probable transmembrane helices predicted for ETEC3618 by TMHMM2.0 at aa 26-48, 58-80, 101-123, 150-172, 184-206 and 226-248
316401014448	PS01005 Formate and nitrite transporters signature 1.
316401014449	PS01006 Formate and nitrite transporters signature 2.
316401014450	siroheme synthase; Provisional; Region: cysG; PRK10637
316401014451	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
316401014452	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
316401014453	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
316401014454	active site
316401014455	SAM binding site [chemical binding]; other site
316401014456	homodimer interface [polypeptide binding]; other site
316401014457	PS00839 Uroporphyrin-III C-methyltransferase signature 1.
316401014458	PS00840 Uroporphyrin-III C-methyltransferase signature 2.
316401014459	Protein of unknown function (DUF4223); Region: DUF4223; pfam13978
316401014460	Signal peptide predicted for ETEC3620 by SignalP 2.0 HMM (Signal peptide probability 0.983) with cleavage site probability 0.595 between residues 22 and 23
316401014461	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401014462	putative fructoselysine transporter; Provisional; Region: frlA; PRK11357
316401014463	hypothetical protein; Provisional; Region: PHA02764
316401014464	11 probable transmembrane helices predicted for ETEC3621 by TMHMM2.0 at aa 10-32, 39-61, 97-119, 126-143, 153-175, 188-210, 230-252, 272-294, 341-363, 384-406 and 411-433
316401014465	fructoselysine-6-P-deglycase; Provisional; Region: frlB; PRK11382
316401014466	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
316401014467	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
316401014468	dimer interface [polypeptide binding]; other site
316401014469	active site
316401014470	PS00017 ATP/GTP-binding site motif A (P-loop).
316401014471	fructoselysine 3-epimerase; Provisional; Region: PRK09856
316401014472	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
316401014473	AP (apurinic/apyrimidinic) site pocket; other site
316401014474	DNA interaction; other site
316401014475	Metal-binding active site; metal-binding site
316401014476	Fructoselysine kinase-like.  Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940
316401014477	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
316401014478	substrate binding site [chemical binding]; other site
316401014479	ATP binding site [chemical binding]; other site
316401014480	PS00583 pfkB family of carbohydrate kinases signature 1.
316401014481	PS00584 pfkB family of carbohydrate kinases signature 2.
316401014482	DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402
316401014483	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
316401014484	DNA-binding site [nucleotide binding]; DNA binding site
316401014485	UTRA domain; Region: UTRA; pfam07702
316401014486	PS00043 Bacterial regulatory proteins, gntR family signature.
316401014487	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
316401014488	DNA topoisomerase III, bacteria and conjugative plasmid; Region: topB; TIGR01056
316401014489	Protein of unknown function; Region: YhfT; pfam10797
316401014490	11 probable transmembrane helices predicted for ETEC3627 by TMHMM2.0 at aa 5-27, 48-70, 90-112, 133-155, 159-176, 183-200, 229-251, 289-311, 321-343, 371-393 and 408-430
316401014491	PS00030 Eukaryotic putative RNA-binding region RNP-1 signature.
316401014492	Signal peptide predicted for ETEC3627 by SignalP 2.0 HMM (Signal peptide probability 0.615) with cleavage site probability 0.492 between residues 21 and 22
316401014493	Protein of unknown function DUF2620; Region: DUF2620; pfam10941
316401014494	1 probable transmembrane helix predicted for ETEC3628 by TMHMM2.0 at aa 47-69
316401014495	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
316401014496	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
316401014497	active site
316401014498	substrate binding pocket [chemical binding]; other site
316401014499	homodimer interaction site [polypeptide binding]; other site
316401014500	PS01323 Phosphotriesterase family signature 2.
316401014501	PS01322 Phosphotriesterase family signature 1.
316401014502	putative mutase; Provisional; Region: PRK12383
316401014503	Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; COG1015
316401014504	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811
316401014505	dimer interface [polypeptide binding]; other site
316401014506	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
316401014507	active site
316401014508	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
316401014509	substrate binding site [chemical binding]; other site
316401014510	catalytic residue [active]
316401014511	PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582
316401014512	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
316401014513	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
316401014514	active site
316401014515	HIGH motif; other site
316401014516	dimer interface [polypeptide binding]; other site
316401014517	KMSKS motif; other site
316401014518	PS00178 Aminoacyl-transfer RNA synthetases class-I signature.
316401014519	phosphoglycolate phosphatase; Provisional; Region: PRK13222
316401014520	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
316401014521	motif II; other site
316401014522	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
316401014523	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
316401014524	substrate binding site [chemical binding]; other site
316401014525	hexamer interface [polypeptide binding]; other site
316401014526	metal binding site [ion binding]; metal-binding site
316401014527	PS01086 Ribulose-phosphate 3-epimerase family signature 2.
316401014528	PS01085 Ribulose-phosphate 3-epimerase family signature 1.
316401014529	DNA adenine methylase; Provisional; Region: PRK10904
316401014530	PS00092 N-6 Adenine-specific DNA methylases signature.
316401014531	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266
316401014532	cell division protein DamX; Validated; Region: PRK10905
316401014533	1 probable transmembrane helix predicted for ETEC3638 by TMHMM2.0 at aa 99-121
316401014534	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
316401014535	active site
316401014536	dimer interface [polypeptide binding]; other site
316401014537	metal binding site [ion binding]; metal-binding site
316401014538	shikimate kinase; Reviewed; Region: aroK; PRK00131
316401014539	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
316401014540	ADP binding site [chemical binding]; other site
316401014541	magnesium binding site [ion binding]; other site
316401014542	putative shikimate binding site; other site
316401014543	PS01128 Shikimate kinase signature.
316401014544	PS00017 ATP/GTP-binding site motif A (P-loop).
316401014545	outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560
316401014546	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
316401014547	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
316401014548	PS00875 Bacterial type II secretion system protein D signature.
316401014549	Protein of unknown function (DUF2531); Region: DUF2531; pfam10748
316401014550	Signal peptide predicted for ETEC3641 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.685 between residues 18 and 19
316401014551	1 probable transmembrane helix predicted for ETEC3643 by TMHMM2.0 at aa 20-37
316401014552	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
316401014553	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
316401014554	Signal peptide predicted for ETEC3644 by SignalP 2.0 HMM (Signal peptide probability 0.937) with cleavage site probability 0.501 between residues 48 and 49
316401014555	1 probable transmembrane helix predicted for ETEC3644 by TMHMM2.0 at aa 21-40
316401014556	penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636
316401014557	Transglycosylase; Region: Transgly; pfam00912
316401014558	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
316401014559	Signal peptide predicted for ETEC3646 by SignalP 2.0 HMM (Signal peptide probability 0.863) with cleavage site probability 0.697 between residues 24 and 25
316401014560	1 probable transmembrane helix predicted for ETEC3646 by TMHMM2.0 at aa 7-29
316401014561	PS00017 ATP/GTP-binding site motif A (P-loop).
316401014562	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
316401014563	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
316401014564	ADP-ribose binding site [chemical binding]; other site
316401014565	dimer interface [polypeptide binding]; other site
316401014566	active site
316401014567	nudix motif; other site
316401014568	metal binding site [ion binding]; metal-binding site
316401014569	PS00893 mutT domain signature.
316401014570	Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095
316401014571	Signal peptide predicted for ETEC3648 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.988 between residues 18 and 19
316401014572	5 probable transmembrane helices predicted for ETEC3648 by TMHMM2.0 at aa 4-22, 202-221, 225-247, 336-358 and 652-674
316401014573	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401014574	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
316401014575	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
316401014576	motif II; other site
316401014577	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
316401014578	RNA binding surface [nucleotide binding]; other site
316401014579	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
316401014580	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
316401014581	dimerization interface [polypeptide binding]; other site
316401014582	domain crossover interface; other site
316401014583	redox-dependent activation switch; other site
316401014584	Domain of unknown function (DUF4153); Region: DUF4153; pfam13687
316401014585	11 probable transmembrane helices predicted for ETEC3652 by TMHMM2.0 at aa 12-34, 39-61, 66-84, 99-118, 138-160, 183-200, 213-235, 250-268, 289-308, 318-340 and 353-375
316401014586	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
316401014587	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
316401014588	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
316401014589	active site
316401014590	substrate-binding site [chemical binding]; other site
316401014591	metal-binding site [ion binding]
316401014592	ATP binding site [chemical binding]; other site
316401014593	PS00017 ATP/GTP-binding site motif A (P-loop).
316401014594	PS00532 Phosphoenolpyruvate carboxykinase (ATP) signature.
316401014595	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
316401014596	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
316401014597	dimerization interface [polypeptide binding]; other site
316401014598	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316401014599	dimer interface [polypeptide binding]; other site
316401014600	phosphorylation site [posttranslational modification]
316401014601	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316401014602	ATP binding site [chemical binding]; other site
316401014603	G-X-G motif; other site
316401014604	2 probable transmembrane helices predicted for ETEC3654 by TMHMM2.0 at aa 15-37 and 160-179
316401014605	Signal peptide predicted for ETEC3654 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.543 between residues 30 and 31
316401014606	PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature.
316401014607	osmolarity response regulator; Provisional; Region: ompR; PRK09468
316401014608	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316401014609	active site
316401014610	phosphorylation site [posttranslational modification]
316401014611	intermolecular recognition site; other site
316401014612	dimerization interface [polypeptide binding]; other site
316401014613	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
316401014614	DNA binding site [nucleotide binding]
316401014615	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
316401014616	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
316401014617	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
316401014618	PS00829 Prokaryotic transcription elongation factors signature 1.
316401014619	PS00830 Prokaryotic transcription elongation factors signature 2.
316401014620	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
316401014621	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
316401014622	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
316401014623	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
316401014624	RNA binding site [nucleotide binding]; other site
316401014625	ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555
316401014626	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
316401014627	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
316401014628	G1 box; other site
316401014629	GTP/Mg2+ binding site [chemical binding]; other site
316401014630	Switch I region; other site
316401014631	G2 box; other site
316401014632	G3 box; other site
316401014633	Switch II region; other site
316401014634	G4 box; other site
316401014635	G5 box; other site
316401014636	Nucleoside recognition; Region: Gate; pfam07670
316401014637	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
316401014638	Nucleoside recognition; Region: Gate; pfam07670
316401014639	PS00017 ATP/GTP-binding site motif A (P-loop).
316401014640	10 probable transmembrane helices predicted for ETEC3659 by TMHMM2.0 at aa 277-299, 309-331, 344-366, 386-408, 421-443, 453-475, 510-532, 663-685, 692-714 and 720-742
316401014641	PS00017 ATP/GTP-binding site motif A (P-loop).
316401014642	putative transposase; Provisional; Region: PRK09857
316401014643	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
316401014644	carboxylesterase BioH; Provisional; Region: PRK10349
316401014645	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
316401014646	DNA utilization protein GntX; Provisional; Region: PRK11595
316401014647	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
316401014648	active site
316401014649	PS00103 Purine/pyrimidine phosphoribosyl transferases signature.
316401014650	Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190
316401014651	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
316401014652	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
316401014653	high-affinity gluconate transporter; Provisional; Region: PRK14984
316401014654	gluconate transporter; Region: gntP; TIGR00791
316401014655	11 probable transmembrane helices predicted for ETEC3665 by TMHMM2.0 at aa 15-37, 50-72, 97-119, 124-146, 175-197, 221-243, 258-280, 293-312, 349-371, 378-400 and 415-437
316401014656	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
316401014657	4-alpha-glucanotransferase; Region: malQ; TIGR00217
316401014658	PS00017 ATP/GTP-binding site motif A (P-loop).
316401014659	maltodextrin phosphorylase; Provisional; Region: PRK14985
316401014660	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
316401014661	homodimer interface [polypeptide binding]; other site
316401014662	active site pocket [active]
316401014663	PS00102 Phosphorylase pyridoxal-phosphate attachment site.
316401014664	transcriptional regulator MalT; Provisional; Region: PRK04841
316401014665	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
316401014666	DNA binding residues [nucleotide binding]
316401014667	dimerization interface [polypeptide binding]; other site
316401014668	PS00622 Bacterial regulatory proteins, luxR family signature.
316401014669	RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204
316401014670	RNA 3' phosphate cyclase domain -  RNA phosphate cyclases are enzymes that catalyze the ATP-dependent conversion of 3'-phosphate at the end of RNA into 2', 3'-cyclic phosphodiester bond. The enzymes are conserved in eucaryotes; Region: RNA_Cyclase; cd00295
316401014671	putative active site [active]
316401014672	adenylation catalytic residue [active]
316401014673	PS01287 RNA 3'-terminal phosphate cyclase signature.
316401014674	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
316401014675	hypothetical protein; Reviewed; Region: PRK09588
316401014676	PS01288 Uncharacterized protein family UPF0027 signature.
316401014677	Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650
316401014678	Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956
316401014679	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316401014680	Walker A motif; other site
316401014681	ATP binding site [chemical binding]; other site
316401014682	Walker B motif; other site
316401014683	arginine finger; other site
316401014684	PS00017 ATP/GTP-binding site motif A (P-loop).
316401014685	PS00676 Sigma-54 interaction domain ATP-binding region B signature.
316401014686	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
316401014687	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
316401014688	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
316401014689	PS00894 Bacterial regulatory proteins, deoR family signature.
316401014690	intramembrane serine protease GlpG; Provisional; Region: PRK10907
316401014691	Protein of unknown function (DUF3582); Region: DUF3582; pfam12122
316401014692	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
316401014693	6 probable transmembrane helices predicted for ETEC3673 by TMHMM2.0 at aa 93-115, 135-157, 169-188, 192-214, 223-245 and 250-272
316401014694	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
316401014695	active site residue [active]
316401014696	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
316401014697	PS00977 FAD-dependent glycerol-3-phosphate dehydrogenase signature 1.
316401014698	PS00978 FAD-dependent glycerol-3-phosphate dehydrogenase signature 2.
316401014699	2 probable transmembrane helices predicted for ETEC3676 by TMHMM2.0 at aa 12-34 and 49-71
316401014700	Signal peptide predicted for ETEC3676 by SignalP 2.0 HMM (Signal peptide probability 0.930) with cleavage site probability 0.720 between residues 22 and 23
316401014701	glycogen phosphorylase; Provisional; Region: PRK14986
316401014702	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
316401014703	homodimer interface [polypeptide binding]; other site
316401014704	active site pocket [active]
316401014705	PS00102 Phosphorylase pyridoxal-phosphate attachment site.
316401014706	glycogen synthase; Provisional; Region: glgA; PRK00654
316401014707	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
316401014708	ADP-binding pocket [chemical binding]; other site
316401014709	homodimer interface [polypeptide binding]; other site
316401014710	PS00589 PTS HPR component serine phosphorylation site signature.
316401014711	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
316401014712	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
316401014713	ligand binding site; other site
316401014714	oligomer interface; other site
316401014715	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
316401014716	sulfate 1 binding site; other site
316401014717	PS00810 ADP-glucose pyrophosphorylase signature 3.
316401014718	PS00809 ADP-glucose pyrophosphorylase signature 2.
316401014719	PS00808 ADP-glucose pyrophosphorylase signature 1.
316401014720	glycogen debranching enzyme; Provisional; Region: PRK03705
316401014721	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
316401014722	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
316401014723	active site
316401014724	catalytic site [active]
316401014725	PS00062 Aldo/keto reductase family signature 2.
316401014726	glycogen branching enzyme; Provisional; Region: PRK05402
316401014727	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
316401014728	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
316401014729	active site
316401014730	catalytic site [active]
316401014731	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
316401014732	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
316401014733	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
316401014734	PS01103 Aspartate-semialdehyde dehydrogenase signature.
316401014735	putative antibiotic transporter; Provisional; Region: PRK10739
316401014736	6 probable transmembrane helices predicted for ETEC3683 by TMHMM2.0 at aa 4-26, 38-57, 72-94, 106-128, 138-160 and 173-195
316401014737	low affinity gluconate transporter; Provisional; Region: PRK10472
316401014738	gluconate transporter; Region: gntP; TIGR00791
316401014739	13 probable transmembrane helices predicted for ETEC3684 by TMHMM2.0 at aa 4-21, 28-47, 57-79, 104-126, 146-168, 175-197, 228-250, 262-284, 299-321, 328-350, 354-373, 386-408 and 423-445
316401014740	Signal peptide predicted for ETEC3684 by SignalP 2.0 HMM (Signal peptide probability 0.680) with cleavage site probability 0.506 between residues 23 and 24
316401014741	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
316401014742	ATP-binding site [chemical binding]; other site
316401014743	Gluconate-6-phosphate binding site [chemical binding]; other site
316401014744	Shikimate kinase; Region: SKI; pfam01202
316401014745	PS00017 ATP/GTP-binding site motif A (P-loop).
316401014746	gluconate operon transcriptional regulator; Provisional; Region: PRK14987
316401014747	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
316401014748	DNA binding site [nucleotide binding]
316401014749	domain linker motif; other site
316401014750	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
316401014751	putative ligand binding site [chemical binding]; other site
316401014752	putative dimerization interface [polypeptide binding]; other site
316401014753	PS00356 Bacterial regulatory proteins, lacI family signature.
316401014754	Pirin-related protein [General function prediction only]; Region: COG1741
316401014755	Pirin; Region: Pirin; pfam02678
316401014756	putative oxidoreductase; Provisional; Region: PRK10206
316401014757	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
316401014758	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
316401014759	PS00017 ATP/GTP-binding site motif A (P-loop).
316401014760	putative acetyltransferase YhhY; Provisional; Region: PRK10140
316401014761	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
316401014762	Coenzyme A binding pocket [chemical binding]; other site
316401014763	Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion,    and vesicular transport]; Region: Hcp; COG3157
316401014764	gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615
316401014765	gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066
316401014766	PS00462 Gamma-glutamyltranspeptidase signature.
316401014767	Signal peptide predicted for ETEC3693 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.976 between residues 25 and 26
316401014768	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401014769	hypothetical protein; Provisional; Region: PRK10350
316401014770	Signal peptide predicted for ETEC3694 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.958 between residues 17 and 18
316401014771	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
316401014772	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
316401014773	putative active site [active]
316401014774	catalytic site [active]
316401014775	putative metal binding site [ion binding]; other site
316401014776	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
316401014777	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
316401014778	Walker A/P-loop; other site
316401014779	ATP binding site [chemical binding]; other site
316401014780	Q-loop/lid; other site
316401014781	ABC transporter signature motif; other site
316401014782	Walker B; other site
316401014783	D-loop; other site
316401014784	H-loop/switch region; other site
316401014785	TOBE domain; Region: TOBE_2; pfam08402
316401014786	PS00211 ABC transporters family signature.
316401014787	PS00017 ATP/GTP-binding site motif A (P-loop).
316401014788	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
316401014789	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401014790	dimer interface [polypeptide binding]; other site
316401014791	conserved gate region; other site
316401014792	putative PBP binding loops; other site
316401014793	ABC-ATPase subunit interface; other site
316401014794	6 probable transmembrane helices predicted for ETEC3697 by TMHMM2.0 at aa 7-29, 82-104, 111-130, 145-162, 200-222 and 251-273
316401014795	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
316401014796	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
316401014797	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401014798	dimer interface [polypeptide binding]; other site
316401014799	conserved gate region; other site
316401014800	putative PBP binding loops; other site
316401014801	ABC-ATPase subunit interface; other site
316401014802	6 probable transmembrane helices predicted for ETEC3698 by TMHMM2.0 at aa 12-34, 79-101, 108-130, 155-177, 206-228 and 266-288
316401014803	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
316401014804	glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974
316401014805	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
316401014806	PS01037 Bacterial extracellular solute-binding proteins, family 1 signature.
316401014807	Signal peptide predicted for ETEC3699 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 23 and 24
316401014808	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614
316401014809	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
316401014810	Walker A/P-loop; other site
316401014811	ATP binding site [chemical binding]; other site
316401014812	Q-loop/lid; other site
316401014813	ABC transporter signature motif; other site
316401014814	Walker B; other site
316401014815	D-loop; other site
316401014816	H-loop/switch region; other site
316401014817	PS00211 ABC transporters family signature.
316401014818	PS00017 ATP/GTP-binding site motif A (P-loop).
316401014819	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
316401014820	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
316401014821	Walker A/P-loop; other site
316401014822	ATP binding site [chemical binding]; other site
316401014823	Q-loop/lid; other site
316401014824	ABC transporter signature motif; other site
316401014825	Walker B; other site
316401014826	D-loop; other site
316401014827	H-loop/switch region; other site
316401014828	PS00211 ABC transporters family signature.
316401014829	PS00017 ATP/GTP-binding site motif A (P-loop).
316401014830	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
316401014831	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
316401014832	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
316401014833	TM-ABC transporter signature motif; other site
316401014834	10 probable transmembrane helices predicted for ETEC3702 by TMHMM2.0 at aa 4-26, 47-66, 91-108, 120-142, 162-184, 193-210, 261-283, 315-337, 352-374 and 381-400
316401014835	Signal peptide predicted for ETEC3702 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.989 between residues 20 and 21
316401014836	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
316401014837	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
316401014838	TM-ABC transporter signature motif; other site
316401014839	8 probable transmembrane helices predicted for ETEC3703 by TMHMM2.0 at aa 15-37, 44-66, 70-92, 105-124, 153-175, 207-229, 244-266 and 282-301
316401014840	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
316401014841	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
316401014842	dimerization interface [polypeptide binding]; other site
316401014843	ligand binding site [chemical binding]; other site
316401014844	Signal peptide predicted for ETEC3704 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 23 and 24
316401014845	Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568
316401014846	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
316401014847	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
316401014848	dimerization interface [polypeptide binding]; other site
316401014849	ligand binding site [chemical binding]; other site
316401014850	Signal peptide predicted for ETEC3706 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 23 and 24
316401014851	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
316401014852	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
316401014853	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
316401014854	DNA binding residues [nucleotide binding]
316401014855	PS00716 Sigma-70 factors family signature 2.
316401014856	PS00715 Sigma-70 factors family signature 1.
316401014857	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
316401014858	putative protein insertion permease FtsX; Region: ftsX; TIGR00439
316401014859	4 probable transmembrane helices predicted for ETEC3708 by TMHMM2.0 at aa 73-95, 219-241, 274-296 and 317-339
316401014860	cell division protein FtsE; Provisional; Region: PRK10908
316401014861	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316401014862	Walker A/P-loop; other site
316401014863	ATP binding site [chemical binding]; other site
316401014864	Q-loop/lid; other site
316401014865	ABC transporter signature motif; other site
316401014866	Walker B; other site
316401014867	D-loop; other site
316401014868	H-loop/switch region; other site
316401014869	PS00211 ABC transporters family signature.
316401014870	PS00017 ATP/GTP-binding site motif A (P-loop).
316401014871	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
316401014872	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
316401014873	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
316401014874	P loop; other site
316401014875	GTP binding site [chemical binding]; other site
316401014876	PS00300 SRP54-type proteins GTP-binding domain signature.
316401014877	PS00017 ATP/GTP-binding site motif A (P-loop).
316401014878	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
316401014879	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316401014880	S-adenosylmethionine binding site [chemical binding]; other site
316401014881	PS00092 N-6 Adenine-specific DNA methylases signature.
316401014882	hypothetical protein; Provisional; Region: PRK10910
316401014883	2 probable transmembrane helices predicted for ETEC3712 by TMHMM2.0 at aa 5-22 and 29-51
316401014884	Protein of unknown function (DUF2500); Region: DUF2500; pfam10694
316401014885	1 probable transmembrane helix predicted for ETEC3713 by TMHMM2.0 at aa 5-24
316401014886	Signal peptide predicted for ETEC3713 by SignalP 2.0 HMM (Signal peptide probability 0.629) with cleavage site probability 0.610 between residues 18 and 19
316401014887	Predicted membrane protein [Function unknown]; Region: COG3714
316401014888	6 probable transmembrane helices predicted for ETEC3714 by TMHMM2.0 at aa 28-45, 50-72, 79-96, 101-123, 130-152 and 156-178
316401014889	zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033
316401014890	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
316401014891	metal-binding site [ion binding]
316401014892	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
316401014893	PS01047 Heavy-metal-associated domain.
316401014894	5 probable transmembrane helices predicted for ETEC3715 by TMHMM2.0 at aa 147-169, 189-211, 350-372, 387-409 and 690-712
316401014895	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
316401014896	PS00154 E1-E2 ATPases phosphorylation site.
316401014897	PS01229 Hypothetical cof family signature 2.
316401014898	PS00141 Eukaryotic and viral aspartyl proteases active site.
316401014899	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
316401014900	CPxP  motif; other site
316401014901	PS01148 Uncharacterized protein family UPF0033 signature.
316401014902	hypothetical protein; Provisional; Region: PRK11212
316401014903	6 probable transmembrane helices predicted for ETEC3717 by TMHMM2.0 at aa 13-32, 42-64, 71-93, 108-130, 142-164 and 179-201
316401014904	hypothetical protein; Provisional; Region: PRK11615
316401014905	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401014906	major facilitator superfamily transporter; Provisional; Region: PRK05122
316401014907	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401014908	putative substrate translocation pore; other site
316401014909	12 probable transmembrane helices predicted for ETEC3719 by TMHMM2.0 at aa 20-42, 47-69, 85-107, 122-144, 151-173, 177-199, 220-242, 252-271, 278-300, 310-332, 339-361 and 366-388
316401014910	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
316401014911	Domain of unknown function DUF20; Region: UPF0118; pfam01594
316401014912	8 probable transmembrane helices predicted for ETEC3720 by TMHMM2.0 at aa 12-29, 33-55, 62-84, 141-163, 192-214, 224-246, 253-275 and 295-317
316401014913	holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351
316401014914	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
316401014915	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
316401014916	The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489
316401014917	substrate binding site [chemical binding]; other site
316401014918	Signal peptide predicted for ETEC3722 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 22 and 23
316401014919	PS01040 Bacterial extracellular solute-binding proteins, family 5 signature.
316401014920	nickel transporter permease NikB; Provisional; Region: PRK10352
316401014921	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401014922	dimer interface [polypeptide binding]; other site
316401014923	conserved gate region; other site
316401014924	putative PBP binding loops; other site
316401014925	ABC-ATPase subunit interface; other site
316401014926	Signal peptide predicted for ETEC3723 by SignalP 2.0 HMM (Signal peptide probability 0.865) with cleavage site probability 0.261 between residues 31 and 32
316401014927	6 probable transmembrane helices predicted for ETEC3723 by TMHMM2.0 at aa 9-31, 101-123, 136-158, 173-195, 230-252 and 280-302
316401014928	nickel transporter permease NikC; Provisional; Region: nikC; PRK10417
316401014929	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401014930	dimer interface [polypeptide binding]; other site
316401014931	conserved gate region; other site
316401014932	putative PBP binding loops; other site
316401014933	ABC-ATPase subunit interface; other site
316401014934	Signal peptide predicted for ETEC3724 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.905 between residues 27 and 28
316401014935	6 probable transmembrane helices predicted for ETEC3724 by TMHMM2.0 at aa 13-32, 78-100, 121-143, 179-198, 205-227 and 242-260
316401014936	nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418
316401014937	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
316401014938	Walker A/P-loop; other site
316401014939	ATP binding site [chemical binding]; other site
316401014940	Q-loop/lid; other site
316401014941	ABC transporter signature motif; other site
316401014942	Walker B; other site
316401014943	D-loop; other site
316401014944	H-loop/switch region; other site
316401014945	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
316401014946	PS00017 ATP/GTP-binding site motif A (P-loop).
316401014947	PS00211 ABC transporters family signature.
316401014948	nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419
316401014949	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
316401014950	Walker A/P-loop; other site
316401014951	ATP binding site [chemical binding]; other site
316401014952	Q-loop/lid; other site
316401014953	ABC transporter signature motif; other site
316401014954	Walker B; other site
316401014955	D-loop; other site
316401014956	H-loop/switch region; other site
316401014957	PS00017 ATP/GTP-binding site motif A (P-loop).
316401014958	PS00211 ABC transporters family signature.
316401014959	nickel responsive regulator; Provisional; Region: PRK02967
316401014960	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
316401014961	PAAR motif; Region: PAAR_motif; cl15808
316401014962	RHS Repeat; Region: RHS_repeat; pfam05593
316401014963	RHS Repeat; Region: RHS_repeat; pfam05593
316401014964	RHS Repeat; Region: RHS_repeat; pfam05593
316401014965	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
316401014966	RHS Repeat; Region: RHS_repeat; pfam05593
316401014967	RHS Repeat; Region: RHS_repeat; pfam05593
316401014968	RHS protein; Region: RHS; pfam03527
316401014969	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
316401014970	Domain of unknown function (DUF4329); Region: DUF4329; pfam14220
316401014971	1 probable transmembrane helix predicted for ETEC3729 by TMHMM2.0 at aa 12-31
316401014972	putative lyase; Provisional; Region: PRK09687
316401014973	IS1 transposase; Region: DDE_Tnp_IS1; pfam03400
316401014974	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
316401014975	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
316401014976	Transposase [DNA replication, recombination, and repair]; Region: COG5433
316401014977	Transposase [DNA replication, recombination, and repair]; Region: COG5433
316401014978	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
316401014979	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
316401014980	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
316401014981	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
316401014982	Walker A/P-loop; other site
316401014983	ATP binding site [chemical binding]; other site
316401014984	Q-loop/lid; other site
316401014985	ABC transporter signature motif; other site
316401014986	Walker B; other site
316401014987	D-loop; other site
316401014988	H-loop/switch region; other site
316401014989	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
316401014990	Walker A/P-loop; other site
316401014991	ATP binding site [chemical binding]; other site
316401014992	Q-loop/lid; other site
316401014993	ABC transporter signature motif; other site
316401014994	Walker B; other site
316401014995	D-loop; other site
316401014996	H-loop/switch region; other site
316401014997	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
316401014998	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
316401014999	5 probable transmembrane helices predicted for ETEC3734 by TMHMM2.0 at aa 717-739, 768-790, 795-817, 824-841 and 884-906
316401015000	PS00017 ATP/GTP-binding site motif A (P-loop).
316401015001	PS00211 ABC transporters family signature.
316401015002	PS00017 ATP/GTP-binding site motif A (P-loop).
316401015003	HlyD family secretion protein; Region: HlyD; pfam00529
316401015004	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
316401015005	HlyD family secretion protein; Region: HlyD_3; pfam13437
316401015006	1 probable transmembrane helix predicted for ETEC3735 by TMHMM2.0 at aa 7-26
316401015007	Signal peptide predicted for ETEC3735 by SignalP 2.0 HMM (Signal peptide probability 0.861) with cleavage site probability 0.380 between residues 23 and 24
316401015008	Domain of unknown function (DUF4049); Region: DUF4049; pfam13258
316401015009	Domain of unknown function (DUF4049); Region: DUF4049; pfam13258
316401015010	Protein of unknown function (DUF2776); Region: DUF2776; pfam10951
316401015011	Signal peptide predicted for ETEC3738 by SignalP 2.0 HMM (Signal peptide probability 0.661) with cleavage site probability 0.311 between residues 29 and 30
316401015012	10 probable transmembrane helices predicted for ETEC3738 by TMHMM2.0 at aa 7-29, 39-61, 74-96, 111-133, 153-175, 190-212, 225-247, 257-279, 291-310 and 325-347
316401015013	Predicted flavoproteins [General function prediction only]; Region: COG2081
316401015014	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
316401015015	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
316401015016	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
316401015017	10 probable transmembrane helices predicted for ETEC3740 by TMHMM2.0 at aa 10-32, 52-74, 94-116, 123-145, 155-177, 207-224, 234-256, 381-403, 418-440 and 474-496
316401015018	PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature.
316401015019	universal stress protein UspB; Provisional; Region: PRK04960
316401015020	2 probable transmembrane helices predicted for ETEC3741 by TMHMM2.0 at aa 5-24 and 90-109
316401015021	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
316401015022	Ligand Binding Site [chemical binding]; other site
316401015023	dipeptide/tripeptide permease B; Provisional; Region: PRK10207
316401015024	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401015025	POT family; Region: PTR2; pfam00854
316401015026	14 probable transmembrane helices predicted for ETEC3743 by TMHMM2.0 at aa 20-42, 52-74, 83-102, 107-124, 145-167, 171-193, 214-233, 237-255, 268-290, 314-336, 349-371, 386-408, 415-437 and 457-479
316401015027	PS01022 PTR2 family proton/oligopeptide symporters signature 1.
316401015028	PS01023 PTR2 family proton/oligopeptide symporters signature 2.
316401015029	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316401015030	S-adenosylmethionine binding site [chemical binding]; other site
316401015031	oligopeptidase A; Provisional; Region: PRK10911
316401015032	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
316401015033	active site
316401015034	Zn binding site [ion binding]; other site
316401015035	PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.
316401015036	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
316401015037	PS00092 N-6 Adenine-specific DNA methylases signature.
316401015038	PS00092 N-6 Adenine-specific DNA methylases signature.
316401015039	glutathione reductase; Validated; Region: PRK06116
316401015040	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
316401015041	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
316401015042	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
316401015043	PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site.
316401015044	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
316401015045	dimerization interface [polypeptide binding]; other site
316401015046	putative DNA binding site [nucleotide binding]; other site
316401015047	putative Zn2+ binding site [ion binding]; other site
316401015048	PS00846 Bacterial regulatory proteins, arsR family signature.
316401015049	arsenical pump membrane protein; Provisional; Region: PRK15445
316401015050	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
316401015051	transmembrane helices; other site
316401015052	11 probable transmembrane helices predicted for ETEC3749 by TMHMM2.0 at aa 2-19, 24-41, 48-70, 90-109, 114-131, 141-163, 176-198, 228-262, 274-296, 316-335 and 401-423
316401015053	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
316401015054	ArsC family; Region: ArsC; pfam03960
316401015055	catalytic residues [active]
316401015056	outer membrane lipoprotein, Slp family; Region: slp; TIGR00752
316401015057	Signal peptide predicted for ETEC3752 by SignalP 2.0 HMM (Signal peptide probability 0.992) with cleavage site probability 0.418 between residues 20 and 21
316401015058	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401015059	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
316401015060	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
316401015061	DNA binding residues [nucleotide binding]
316401015062	dimerization interface [polypeptide binding]; other site
316401015063	putative Mg(2+) transport ATPase; Provisional; Region: PRK09977
316401015064	MgtC family; Region: MgtC; pfam02308
316401015065	5 probable transmembrane helices predicted for ETEC3754 by TMHMM2.0 at aa 5-22, 35-54, 69-87, 92-114 and 118-140
316401015066	acid-resistance protein; Provisional; Region: hdeB; PRK11566
316401015067	Signal peptide predicted for ETEC3755 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.954 between residues 29 and 30
316401015068	acid-resistance protein; Provisional; Region: PRK10208
316401015069	1 probable transmembrane helix predicted for ETEC3756 by TMHMM2.0 at aa 4-22
316401015070	Signal peptide predicted for ETEC3756 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.986 between residues 21 and 22
316401015071	acid-resistance membrane protein; Provisional; Region: PRK10209
316401015072	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
316401015073	6 probable transmembrane helices predicted for ETEC3757 by TMHMM2.0 at aa 26-44, 48-70, 77-99, 104-126, 139-161 and 165-187
316401015074	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
316401015075	pyruvate kinase; Provisional; Region: PRK05826
316401015076	multidrug efflux system protein MdtE; Provisional; Region: PRK09859
316401015077	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
316401015078	HlyD family secretion protein; Region: HlyD_3; pfam13437
316401015079	Signal peptide predicted for ETEC3759 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.911 between residues 20 and 21
316401015080	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401015081	multidrug efflux system protein AcrB; Provisional; Region: PRK15127
316401015082	Protein export membrane protein; Region: SecD_SecF; cl14618
316401015083	11 probable transmembrane helices predicted for ETEC3760 by TMHMM2.0 at aa 10-32, 340-362, 366-388, 442-464, 474-496, 539-561, 871-890, 895-914, 924-946, 973-995 and 1005-1027
316401015084	PS00017 ATP/GTP-binding site motif A (P-loop).
316401015085	transcriptional regulator YdeO; Provisional; Region: PRK09940
316401015086	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316401015087	PS00041 Bacterial regulatory proteins, araC family signature.
316401015088	DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978
316401015089	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316401015090	PS00041 Bacterial regulatory proteins, araC family signature.
316401015091	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
316401015092	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316401015093	catalytic residue [active]
316401015094	PS00392 DDC / GAD / HDC / TyrDC pyridoxal-phosphate attachment site.
316401015095	PS01039 Bacterial extracellular solute-binding proteins, family 3 signature.
316401015096	Haem-binding domain; Region: Haem_bd; pfam14376
316401015097	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
316401015098	PS00190 Cytochrome c family heme-binding site signature.
316401015099	PS00190 Cytochrome c family heme-binding site signature.
316401015100	PS00190 Cytochrome c family heme-binding site signature.
316401015101	1 probable transmembrane helix predicted for ETEC3764 by TMHMM2.0 at aa 7-29
316401015102	trehalase; Provisional; Region: treF; PRK13270
316401015103	Trehalase; Region: Trehalase; pfam01204
316401015104	PS00927 Trehalase signature 1.
316401015105	PS00928 Trehalase signature 2.
316401015106	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
316401015107	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
316401015108	DNA binding residues [nucleotide binding]
316401015109	dimerization interface [polypeptide binding]; other site
316401015110	PS00622 Bacterial regulatory proteins, luxR family signature.
316401015111	Transcriptional regulator [Transcription]; Region: LysR; COG0583
316401015112	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401015113	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
316401015114	putative effector binding pocket; other site
316401015115	putative dimerization interface [polypeptide binding]; other site
316401015116	PS00044 Bacterial regulatory proteins, lysR family signature.
316401015117	inner membrane protein YhjD; Region: TIGR00766
316401015118	6 probable transmembrane helices predicted for ETEC3768 by TMHMM2.0 at aa 75-97, 134-156, 186-208, 228-250, 262-284 and 299-321
316401015119	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401015120	metabolite-proton symporter; Region: 2A0106; TIGR00883
316401015121	putative substrate translocation pore; other site
316401015122	11 probable transmembrane helices predicted for ETEC3769 by TMHMM2.0 at aa 24-46, 66-88, 109-131, 166-188, 195-217, 247-269, 290-312, 322-341, 346-368, 383-405 and 410-432
316401015123	PS00359 Ribosomal protein L11 signature.
316401015124	PS00216 Sugar transport proteins signature 1.
316401015125	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
316401015126	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
316401015127	1 probable transmembrane helix predicted for ETEC3770 by TMHMM2.0 at aa 12-34
316401015128	Signal peptide predicted for ETEC3770 by SignalP 2.0 HMM (Signal peptide probability 0.977) with cleavage site probability 0.589 between residues 27 and 28
316401015129	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
316401015130	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
316401015131	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
316401015132	substrate binding site [chemical binding]; other site
316401015133	ATP binding site [chemical binding]; other site
316401015134	PS00584 pfkB family of carbohydrate kinases signature 2.
316401015135	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
316401015136	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
316401015137	Signal peptide predicted for ETEC3773 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 24 and 25
316401015138	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
316401015139	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
316401015140	8 probable transmembrane helices predicted for ETEC3774 by TMHMM2.0 at aa 5-27, 47-64, 77-99, 141-163, 184-206, 219-241, 326-348 and 352-374
316401015141	PS00714 Sodium:dicarboxylate symporter family signature 2.
316401015142	PS00713 Sodium:dicarboxylate symporter family signature 1.
316401015143	putative diguanylate cyclase; Provisional; Region: PRK13561
316401015144	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316401015145	metal binding site [ion binding]; metal-binding site
316401015146	active site
316401015147	I-site; other site
316401015148	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
316401015149	2 probable transmembrane helices predicted for ETEC3775 by TMHMM2.0 at aa 5-22 and 143-165
316401015150	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
316401015151	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
316401015152	binding surface
316401015153	TPR motif; other site
316401015154	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
316401015155	binding surface
316401015156	TPR motif; other site
316401015157	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
316401015158	Signal peptide predicted for ETEC3776 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 23 and 24
316401015159	endo-1,4-D-glucanase; Provisional; Region: PRK11097
316401015160	PS00812 Glycosyl hydrolases family 8 signature.
316401015161	Signal peptide predicted for ETEC3777 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.960 between residues 21 and 22
316401015162	cellulose synthase regulator protein; Provisional; Region: PRK11114
316401015163	1 probable transmembrane helix predicted for ETEC3778 by TMHMM2.0 at aa 741-763
316401015164	Signal peptide predicted for ETEC3778 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 25 and 26
316401015165	cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498
316401015166	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
316401015167	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
316401015168	DXD motif; other site
316401015169	PilZ domain; Region: PilZ; pfam07238
316401015170	10 probable transmembrane helices predicted for ETEC3779 by TMHMM2.0 at aa 28-50, 150-169, 173-190, 197-216, 229-251, 522-541, 545-567, 588-610, 633-655 and 668-690
316401015171	PS00215 Mitochondrial energy transfer proteins signature.
316401015172	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401015173	cell division protein; Provisional; Region: PRK10037
316401015174	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
316401015175	P-loop; other site
316401015176	Magnesium ion binding site [ion binding]; other site
316401015177	cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045
316401015178	Protein of unknown function (DUF2819); Region: DUF2819; pfam10995
316401015179	PS00228 Tubulin-beta mRNA autoregulation signal.
316401015180	celllulose biosynthesis operon protein BcsF/YhjT; Region: cellullose_BcsF; TIGR03493
316401015181	1 probable transmembrane helix predicted for ETEC3782 by TMHMM2.0 at aa 7-29
316401015182	Protein of unknown function (DUF3260); Region: DUF3260; pfam11658
316401015183	4 probable transmembrane helices predicted for ETEC3783 by TMHMM2.0 at aa 33-55, 68-85, 114-133 and 140-162
316401015184	Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940
316401015185	1 probable transmembrane helix predicted for ETEC3783A by TMHMM2.0 at aa 65-87
316401015186	Similar to Escherichia coli B serine transporter. UniProt:A2UJ81 (423 aa) fasta scores: E()=1.6e-141, 97.430% id in 428 aa, and to shigella flexneri serotype 5b (strain 8401). yhjv UniProt:Q0SZD3 (EMBL:CP000266 (444 aa) fasta scores: E()=2.2e-149, 96.882% id in 449 aa. Putative frameshift mutation around codon 120. These CDS could potentially be transcribed as two separate CDS.
316401015187	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
316401015188	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
316401015189	Walker A/P-loop; other site
316401015190	ATP binding site [chemical binding]; other site
316401015191	Q-loop/lid; other site
316401015192	ABC transporter signature motif; other site
316401015193	Walker B; other site
316401015194	D-loop; other site
316401015195	H-loop/switch region; other site
316401015196	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
316401015197	PS00211 ABC transporters family signature.
316401015198	PS00017 ATP/GTP-binding site motif A (P-loop).
316401015199	dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022
316401015200	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
316401015201	Walker A/P-loop; other site
316401015202	ATP binding site [chemical binding]; other site
316401015203	Q-loop/lid; other site
316401015204	ABC transporter signature motif; other site
316401015205	Walker B; other site
316401015206	D-loop; other site
316401015207	H-loop/switch region; other site
316401015208	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
316401015209	PS00211 ABC transporters family signature.
316401015210	PS00017 ATP/GTP-binding site motif A (P-loop).
316401015211	dipeptide transporter; Provisional; Region: PRK10913
316401015212	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
316401015213	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401015214	dimer interface [polypeptide binding]; other site
316401015215	conserved gate region; other site
316401015216	putative PBP binding loops; other site
316401015217	ABC-ATPase subunit interface; other site
316401015218	5 probable transmembrane helices predicted for ETEC3787 by TMHMM2.0 at aa 31-53, 103-125, 140-162, 210-232 and 265-287
316401015219	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
316401015220	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401015221	dimer interface [polypeptide binding]; other site
316401015222	conserved gate region; other site
316401015223	putative PBP binding loops; other site
316401015224	ABC-ATPase subunit interface; other site
316401015225	6 probable transmembrane helices predicted for ETEC3788 by TMHMM2.0 at aa 9-31, 99-121, 134-156, 202-221, 258-280 and 309-331
316401015226	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
316401015227	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
316401015228	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
316401015229	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
316401015230	peptide binding site [polypeptide binding]; other site
316401015231	PS01040 Bacterial extracellular solute-binding proteins, family 5 signature.
316401015232	Signal peptide predicted for ETEC3789 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 28 and 29
316401015233	phosphoethanolamine transferase; Provisional; Region: PRK11560
316401015234	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
316401015235	Sulfatase; Region: Sulfatase; pfam00884
316401015236	5 probable transmembrane helices predicted for ETEC3790 by TMHMM2.0 at aa 12-31, 46-68, 81-103, 118-140 and 161-178
316401015237	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
316401015238	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401015239	putative substrate translocation pore; other site
316401015240	12 probable transmembrane helices predicted for ETEC3791 by TMHMM2.0 at aa 12-34, 44-66, 73-95, 100-122, 135-154, 169-186, 217-236, 251-273, 280-302, 307-329, 342-364 and 368-387
316401015241	Signal peptide predicted for ETEC3791 by SignalP 2.0 HMM (Signal peptide probability 0.621) with cleavage site probability 0.549 between residues 25 and 26
316401015243	3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353
316401015244	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
316401015245	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
316401015246	Coenzyme A binding pocket [chemical binding]; other site
316401015247	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
316401015248	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
316401015249	molybdopterin cofactor binding site [chemical binding]; other site
316401015250	substrate binding site [chemical binding]; other site
316401015251	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
316401015252	molybdopterin cofactor binding site; other site
316401015253	PS00932 Prokaryotic molybdopterin oxidoreductases signature 3.
316401015254	PS00017 ATP/GTP-binding site motif A (P-loop).
316401015255	PS00490 Prokaryotic molybdopterin oxidoreductases signature 2.
316401015256	putative outer membrane lipoprotein; Provisional; Region: PRK10510
316401015257	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
316401015258	ligand binding site [chemical binding]; other site
316401015259	Signal peptide predicted for ETEC3796 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.790 between residues 20 and 21
316401015260	3 probable transmembrane helices predicted for ETEC3796 by TMHMM2.0 at aa 5-27, 37-55 and 62-84
316401015261	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401015262	PS00017 ATP/GTP-binding site motif A (P-loop).
316401015263	PS01068 OmpA-like domain.
316401015264	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
316401015265	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
316401015266	dimerization interface [polypeptide binding]; other site
316401015267	ligand binding site [chemical binding]; other site
316401015268	NADP binding site [chemical binding]; other site
316401015269	catalytic site [active]
316401015270	PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2.
316401015271	PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3.
316401015272	Protein of unknown function (DUF3053); Region: DUF3053; pfam11254
316401015273	1 probable transmembrane helix predicted for ETEC3798 by TMHMM2.0 at aa 10-27
316401015274	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401015275	Predicted transcriptional regulator [Transcription]; Region: COG2944
316401015276	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
316401015277	non-specific DNA binding site [nucleotide binding]; other site
316401015278	salt bridge; other site
316401015279	sequence-specific DNA binding site [nucleotide binding]; other site
316401015280	small toxic polypeptide; Provisional; Region: PRK09759
316401015281	PS00556 Hok/gef family cell toxic proteins signature.
316401015282	1 probable transmembrane helix predicted for ETEC3800 by TMHMM2.0 at aa 7-24
316401015283	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
316401015284	Helix-turn-helix domain; Region: HTH_28; pfam13518
316401015285	Helix-turn-helix domain; Region: HTH_28; pfam13518
316401015286	putative transposase OrfB; Reviewed; Region: PHA02517
316401015287	HTH-like domain; Region: HTH_21; pfam13276
316401015288	Integrase core domain; Region: rve; pfam00665
316401015289	Integrase core domain; Region: rve_2; pfam13333
316401015290	glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211
316401015291	DALR anticodon binding domain; Region: DALR_1; pfam05746
316401015292	anticodon binding site; other site
316401015293	tRNA binding surface [nucleotide binding]; other site
316401015294	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
316401015295	dimer interface [polypeptide binding]; other site
316401015296	motif 1; other site
316401015297	active site
316401015298	motif 2; other site
316401015299	motif 3; other site
316401015300	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
316401015301	YsaB-like lipoprotein; Region: YsaB; pfam13983
316401015302	Signal peptide predicted for ETEC3805 by SignalP 2.0 HMM (Signal peptide probability 0.964) with cleavage site probability 0.787 between residues 26 and 27
316401015303	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401015304	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
316401015305	Acyltransferase family; Region: Acyl_transf_3; pfam01757
316401015306	10 probable transmembrane helices predicted for ETEC3806 by TMHMM2.0 at aa 13-30, 45-67, 79-101, 114-136, 143-160, 170-189, 202-224, 235-254, 266-288 and 298-320
316401015307	hypothetical protein; Provisional; Region: PRK11383
316401015308	yiaA/B two helix domain; Region: YiaAB; pfam05360
316401015309	yiaA/B two helix domain; Region: YiaAB; pfam05360
316401015310	4 probable transmembrane helices predicted for ETEC3807 by TMHMM2.0 at aa 13-32, 42-59, 72-94 and 99-121
316401015311	hypothetical protein; Provisional; Region: PRK11403
316401015312	yiaA/B two helix domain; Region: YiaAB; cl01759
316401015313	3 probable transmembrane helices predicted for ETEC3807A by TMHMM2.0 at aa 7-29, 49-71 and 78-95
316401015314	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401015315	IS1 transposase; Region: DDE_Tnp_IS1; pfam03400
316401015316	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
316401015317	putative ligand binding site [chemical binding]; other site
316401015318	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
316401015319	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
316401015320	Walker A/P-loop; other site
316401015321	ATP binding site [chemical binding]; other site
316401015322	Q-loop/lid; other site
316401015323	ABC transporter signature motif; other site
316401015324	Walker B; other site
316401015325	D-loop; other site
316401015326	H-loop/switch region; other site
316401015327	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
316401015328	PS00017 ATP/GTP-binding site motif A (P-loop).
316401015329	PS00211 ABC transporters family signature.
316401015330	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
316401015331	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
316401015332	TM-ABC transporter signature motif; other site
316401015333	10 probable transmembrane helices predicted for ETEC3811 by TMHMM2.0 at aa 24-46, 61-80, 85-107, 111-133, 140-162, 177-196, 216-235, 240-259, 331-353 and 368-385
316401015334	Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543
316401015335	putative dimerization interface [polypeptide binding]; other site
316401015336	Transcriptional regulators [Transcription]; Region: PurR; COG1609
316401015337	putative ligand binding site [chemical binding]; other site
316401015338	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316401015339	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
316401015340	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316401015341	PS00041 Bacterial regulatory proteins, araC family signature.
316401015342	hypothetical protein; Provisional; Region: PRK10356
316401015343	Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992
316401015344	PS00017 ATP/GTP-binding site motif A (P-loop).
316401015345	Signal peptide predicted for ETEC3813 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.989 between residues 27 and 28
316401015346	alpha-amylase; Reviewed; Region: malS; PRK09505
316401015347	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
316401015348	active site
316401015349	catalytic site [active]
316401015350	Signal peptide predicted for ETEC3814 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.723 between residues 17 and 18
316401015351	valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440
316401015352	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
316401015353	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316401015354	homodimer interface [polypeptide binding]; other site
316401015355	catalytic residue [active]
316401015356	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
316401015357	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
316401015358	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401015359	Transcriptional regulator [Transcription]; Region: IclR; COG1414
316401015360	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
316401015361	Bacterial transcriptional regulator; Region: IclR; pfam01614
316401015362	PS01051 Bacterial regulatory proteins, iclR family signature.
316401015363	2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260
316401015364	uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022
316401015365	2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877
316401015366	4 probable transmembrane helices predicted for ETEC3820 by TMHMM2.0 at aa 7-29, 44-66, 79-98 and 113-135
316401015367	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401015368	L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060
316401015369	DctM-like transporters; Region: DctM; pfam06808
316401015370	Signal peptide predicted for ETEC3821 by SignalP 2.0 HMM (Signal peptide probability 0.717) with cleavage site probability 0.524 between residues 23 and 24
316401015371	11 probable transmembrane helices predicted for ETEC3821 by TMHMM2.0 at aa 4-26, 47-69, 102-124, 137-159, 169-191, 211-230, 234-256, 277-299, 314-343, 355-377 and 397-419
316401015372	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
316401015373	tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787
316401015374	Signal peptide predicted for ETEC3822 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.990 between residues 24 and 25
316401015375	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
316401015376	L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802
316401015377	putative N- and C-terminal domain interface [polypeptide binding]; other site
316401015378	putative active site [active]
316401015379	MgATP binding site [chemical binding]; other site
316401015380	catalytic site [active]
316401015381	metal binding site [ion binding]; metal-binding site
316401015382	putative xylulose binding site [chemical binding]; other site
316401015383	PS00445 FGGY family of carbohydrate kinases signature 2.
316401015384	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
316401015385	active site
316401015386	dimer interface [polypeptide binding]; other site
316401015387	magnesium binding site [ion binding]; other site
316401015388	putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210
316401015389	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
316401015390	AP (apurinic/apyrimidinic) site pocket; other site
316401015391	DNA interaction; other site
316401015392	Metal-binding active site; metal-binding site
316401015393	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
316401015394	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
316401015395	intersubunit interface [polypeptide binding]; other site
316401015396	active site
316401015397	Zn2+ binding site [ion binding]; other site
316401015398	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
316401015399	IS1 transposase; Region: DDE_Tnp_IS1; pfam03400
316401015400	Transcriptional regulator [Transcription]; Region: LysR; COG0583
316401015401	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401015402	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
316401015403	PS00044 Bacterial regulatory proteins, lysR family signature.
316401015404	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
316401015405	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
316401015406	HlyD family secretion protein; Region: HlyD_3; pfam13437
316401015407	2 probable transmembrane helices predicted for ETEC3830 by TMHMM2.0 at aa 3-17 and 27-49
316401015408	Protein of unknown function (DUF3302); Region: DUF3302; pfam11742
316401015409	FlxA-like protein; Region: FlxA; pfam14282
316401015410	2 probable transmembrane helices predicted for ETEC3831 by TMHMM2.0 at aa 7-29 and 44-66
316401015411	1 probable transmembrane helix predicted for ETEC3831A by TMHMM2.0 at aa 42-61
316401015412	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
316401015413	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
316401015414	NAD(P) binding site [chemical binding]; other site
316401015415	catalytic residues [active]
316401015416	PS00070 Aldehyde dehydrogenases cysteine active site.
316401015417	PS00687 Aldehyde dehydrogenases glutamic acid active site.
316401015418	putative alcohol dehydrogenase; Provisional; Region: PRK09860
316401015419	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
316401015420	dimer interface [polypeptide binding]; other site
316401015421	active site
316401015422	metal binding site [ion binding]; metal-binding site
316401015423	PS00060 Iron-containing alcohol dehydrogenases signature 2.
316401015424	PS00913 Iron-containing alcohol dehydrogenases signature 1.
316401015425	selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
316401015426	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
316401015427	G1 box; other site
316401015428	putative GEF interaction site [polypeptide binding]; other site
316401015429	GTP/Mg2+ binding site [chemical binding]; other site
316401015430	Switch I region; other site
316401015431	G2 box; other site
316401015432	G3 box; other site
316401015433	Switch II region; other site
316401015434	G4 box; other site
316401015435	G5 box; other site
316401015436	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
316401015437	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
316401015438	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
316401015439	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
316401015440	PS00301 GTP-binding elongation factors signature.
316401015441	PS00017 ATP/GTP-binding site motif A (P-loop).
316401015442	selenocysteine synthase; Provisional; Region: PRK04311
316401015443	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
316401015444	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
316401015445	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
316401015446	catalytic residue [active]
316401015447	putative glutathione S-transferase; Provisional; Region: PRK10357
316401015448	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
316401015449	putative C-terminal domain interface [polypeptide binding]; other site
316401015450	putative GSH binding site (G-site) [chemical binding]; other site
316401015451	putative dimer interface [polypeptide binding]; other site
316401015452	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
316401015453	dimer interface [polypeptide binding]; other site
316401015454	N-terminal domain interface [polypeptide binding]; other site
316401015455	putative substrate binding pocket (H-site) [chemical binding]; other site
316401015456	PAAR motif; Region: PAAR_motif; cl15808
316401015457	RHS Repeat; Region: RHS_repeat; pfam05593
316401015458	RHS Repeat; Region: RHS_repeat; pfam05593
316401015459	RHS Repeat; Region: RHS_repeat; pfam05593
316401015460	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
316401015461	RHS Repeat; Region: RHS_repeat; pfam05593
316401015462	RHS Repeat; Region: RHS_repeat; pfam05593
316401015463	RHS protein; Region: RHS; pfam03527
316401015464	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
316401015468	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
316401015469	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
316401015470	HlyD family secretion protein; Region: HlyD_3; pfam13437
316401015471	2 probable transmembrane helices predicted for ETEC3839 by TMHMM2.0 at aa 5-22 and 27-49
316401015472	Protein of unknown function (DUF3302); Region: DUF3302; pfam11742
316401015473	2 probable transmembrane helices predicted for ETEC3840 by TMHMM2.0 at aa 2-24 and 44-66
316401015474	PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083
316401015475	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
316401015476	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
316401015477	active site
316401015478	P-loop; other site
316401015479	phosphorylation site [posttranslational modification]
316401015480	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
316401015481	active site
316401015482	phosphorylation site [posttranslational modification]
316401015483	8 probable transmembrane helices predicted for ETEC3841 by TMHMM2.0 at aa 20-42, 52-74, 87-109, 129-151, 212-234, 244-263, 270-292 and 312-334
316401015484	PS00372 PTS EIIA domains phosphorylation site signature 2.
316401015485	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
316401015486	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
316401015487	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
316401015488	PS00974 Mannitol dehydrogenases signature.
316401015489	Transcriptional regulator [Transcription]; Region: MtlR; COG3722
316401015490	mannitol repressor protein; Provisional; Region: mtlR; PRK11001
316401015491	hypothetical protein; Provisional; Region: PRK11020
316401015492	L-lactate permease; Provisional; Region: PRK10420
316401015493	glycolate transporter; Provisional; Region: PRK09695
316401015494	12 probable transmembrane helices predicted for ETEC3846 by TMHMM2.0 at aa 10-32, 39-58, 68-90, 119-141, 161-183, 195-217, 244-266, 368-387, 407-426, 433-455, 498-515 and 528-550
316401015495	DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421
316401015496	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
316401015497	DNA-binding site [nucleotide binding]; DNA binding site
316401015498	FCD domain; Region: FCD; pfam07729
316401015499	PS00043 Bacterial regulatory proteins, gntR family signature.
316401015500	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
316401015501	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
316401015502	phosphate binding site [ion binding]; other site
316401015503	PS00557 FMN-dependent alpha-hydroxy acid dehydrogenases active site.
316401015504	putative rRNA methylase; Provisional; Region: PRK10358
316401015505	serine acetyltransferase; Provisional; Region: cysE; PRK11132
316401015506	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
316401015507	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
316401015508	trimer interface [polypeptide binding]; other site
316401015509	active site
316401015510	substrate binding site [chemical binding]; other site
316401015511	CoA binding site [chemical binding]; other site
316401015512	PS00101 Hexapeptide-repeat containing-transferases signature.
316401015513	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
316401015514	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
316401015515	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
316401015516	PS00957 NAD-dependent glycerol-3-phosphate dehydrogenase signature.
316401015517	Signal peptide predicted for ETEC3851 by SignalP 2.0 HMM (Signal peptide probability 0.868) with cleavage site probability 0.764 between residues 21 and 22
316401015518	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
316401015519	SecA binding site; other site
316401015520	Preprotein binding site; other site
316401015521	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
316401015522	GSH binding site [chemical binding]; other site
316401015523	catalytic residues [active]
316401015524	PS00195 Glutaredoxin active site.
316401015525	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
316401015526	active site residue [active]
316401015527	1 probable transmembrane helix predicted for ETEC3854 by TMHMM2.0 at aa 7-29
316401015528	phosphoglyceromutase; Provisional; Region: PRK05434
316401015529	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307
316401015530	AmiB activator; Provisional; Region: PRK11637
316401015531	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
316401015532	Peptidase family M23; Region: Peptidase_M23; pfam01551
316401015533	Signal peptide predicted for ETEC3856 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 34 and 35
316401015534	1 probable transmembrane helix predicted for ETEC3856 by TMHMM2.0 at aa 12-34
316401015535	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
316401015536	NodB motif; other site
316401015537	putative active site [active]
316401015538	putative catalytic site [active]
316401015539	Zn binding site [ion binding]; other site
316401015540	Signal peptide predicted for ETEC3857 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 23 and 24
316401015541	1 probable transmembrane helix predicted for ETEC3857 by TMHMM2.0 at aa 7-29
316401015542	putative glycosyl transferase; Provisional; Region: PRK10073
316401015543	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
316401015544	active site
316401015545	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
316401015546	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
316401015547	NAD(P) binding site [chemical binding]; other site
316401015548	PS00059 Zinc-containing alcohol dehydrogenases signature.
316401015549	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
316401015550	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
316401015551	substrate-cofactor binding pocket; other site
316401015552	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316401015553	catalytic residue [active]
316401015554	PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site.
316401015555	hypothetical protein; Provisional; Region: PRK11346
316401015556	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
316401015557	ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150
316401015558	NADP binding site [chemical binding]; other site
316401015559	homopentamer interface [polypeptide binding]; other site
316401015560	substrate binding site [chemical binding]; other site
316401015561	active site
316401015562	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
316401015563	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
316401015564	putative active site [active]
316401015565	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
316401015566	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
316401015567	putative active site [active]
316401015568	O-Antigen ligase; Region: Wzy_C; pfam04932
316401015569	10 probable transmembrane helices predicted for ETEC3865 by TMHMM2.0 at aa 7-29, 33-51, 63-82, 97-116, 129-151, 161-183, 203-225, 235-254, 342-364 and 384-406
316401015570	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
316401015571	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
316401015572	active site
316401015573	lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171
316401015574	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
316401015575	Ligand binding site; other site
316401015576	metal-binding site
316401015577	Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437
316401015578	Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176
316401015579	lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171
316401015580	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
316401015581	Ligand binding site; other site
316401015582	metal-binding site
316401015583	Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437
316401015584	lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171
316401015585	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
316401015586	Ligand binding site; other site
316401015587	metal-binding site
316401015588	Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437
316401015589	lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123
316401015590	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
316401015591	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
316401015592	PS00225 Crystallins beta and gamma 'Greek key' motif signature.
316401015593	lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422
316401015594	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
316401015595	putative active site [active]
316401015596	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
316401015597	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
316401015598	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
316401015599	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
316401015600	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
316401015601	active site
316401015602	(T/H)XGH motif; other site
316401015603	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
316401015604	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
316401015605	DNA binding site [nucleotide binding]
316401015606	catalytic residue [active]
316401015607	H2TH interface [polypeptide binding]; other site
316401015608	putative catalytic residues [active]
316401015609	turnover-facilitating residue; other site
316401015610	intercalation triad [nucleotide binding]; other site
316401015611	8OG recognition residue [nucleotide binding]; other site
316401015612	putative reading head residues; other site
316401015613	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
316401015614	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
316401015615	PS01242 Formamidopyrimidine-DNA glycosylase signature.
316401015616	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
316401015617	PS00582 Ribosomal protein L33 signature.
316401015618	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
316401015619	hypothetical protein; Reviewed; Region: PRK00024
316401015620	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
316401015621	MPN+ (JAMM) motif; other site
316401015622	Zinc-binding site [ion binding]; other site
316401015623	PS01302 DNA repair protein radC family signature.
316401015624	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
316401015625	Flavoprotein; Region: Flavoprotein; pfam02441
316401015626	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
316401015627	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
316401015628	trimer interface [polypeptide binding]; other site
316401015629	active site
316401015630	division inhibitor protein; Provisional; Region: slmA; PRK09480
316401015631	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
316401015632	PS01081 Bacterial regulatory proteins, tetR family signature.
316401015633	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
316401015634	active site
316401015635	PS00103 Purine/pyrimidine phosphoribosyl transferases signature.
316401015636	ribonuclease PH; Reviewed; Region: rph; PRK00173
316401015637	Ribonuclease PH; Region: RNase_PH_bact; cd11362
316401015638	hexamer interface [polypeptide binding]; other site
316401015639	active site
316401015640	PS01277 Ribonuclease PH signature.
316401015641	hypothetical protein; Provisional; Region: PRK11820
316401015642	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
316401015643	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
316401015644	DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525
316401015645	BRO family, N-terminal domain; Region: Bro-N; pfam02498
316401015646	PS00225 Crystallins beta and gamma 'Greek key' motif signature.
316401015647	Predicted membrane protein [Function unknown]; Region: COG2860
316401015648	UPF0126 domain; Region: UPF0126; pfam03458
316401015649	UPF0126 domain; Region: UPF0126; pfam03458
316401015650	7 probable transmembrane helices predicted for ETEC3887 by TMHMM2.0 at aa 5-22, 29-51, 64-81, 88-109, 114-136, 148-167 and 172-189
316401015651	NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097
316401015652	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
316401015653	nucleotide binding pocket [chemical binding]; other site
316401015654	K-X-D-G motif; other site
316401015655	catalytic site [active]
316401015656	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
316401015657	PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide.
316401015658	PS01056 NAD-dependent DNA ligase signature 2.
316401015659	PS01055 NAD-dependent DNA ligase signature 1.
316401015660	Signal peptide predicted for ETEC3888 by SignalP 2.0 HMM (Signal peptide probability 0.975) with cleavage site probability 0.690 between residues 20 and 21
316401015661	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
316401015662	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
316401015663	catalytic site [active]
316401015664	G-X2-G-X-G-K; other site
316401015665	PS00017 ATP/GTP-binding site motif A (P-loop).
316401015666	PS00856 Guanylate kinase signature.
316401015667	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
316401015668	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
316401015669	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
316401015670	Zn2+ binding site [ion binding]; other site
316401015671	Mg2+ binding site [ion binding]; other site
316401015672	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
316401015673	synthetase active site [active]
316401015674	NTP binding site [chemical binding]; other site
316401015675	metal binding site [ion binding]; metal-binding site
316401015676	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
316401015677	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
316401015678	tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081
316401015679	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
316401015680	SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105
316401015681	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
316401015682	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
316401015683	generic binding surface II; other site
316401015684	ssDNA binding site; other site
316401015685	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
316401015686	ATP binding site [chemical binding]; other site
316401015687	putative Mg++ binding site [ion binding]; other site
316401015688	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
316401015689	nucleotide binding region [chemical binding]; other site
316401015690	ATP-binding site [chemical binding]; other site
316401015691	PS00017 ATP/GTP-binding site motif A (P-loop).
316401015692	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
316401015693	9 probable transmembrane helices predicted for ETEC3894 by TMHMM2.0 at aa 70-87, 94-116, 157-179, 213-235, 245-267, 274-292, 302-324, 336-358 and 368-390
316401015694	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
316401015695	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401015696	11 probable transmembrane helices predicted for ETEC3895 by TMHMM2.0 at aa 43-65, 90-112, 127-149, 156-178, 193-212, 219-241, 261-283, 346-368, 378-400, 407-429 and 439-458
316401015697	PS01116 Xanthine/uracil permeases family signature.
316401015698	AsmA family; Region: AsmA; pfam05170
316401015699	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
316401015700	Signal peptide predicted for ETEC3896 by SignalP 2.0 HMM (Signal peptide probability 0.907) with cleavage site probability 0.372 between residues 31 and 32
316401015701	1 probable transmembrane helix predicted for ETEC3896 by TMHMM2.0 at aa 7-26
316401015702	PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide.
316401015703	putative alpha-glucosidase; Provisional; Region: PRK10658
316401015704	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
316401015705	YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593
316401015706	active site
316401015707	homotrimer interface [polypeptide binding]; other site
316401015708	catalytic site [active]
316401015709	homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site
316401015710	putative transporter; Provisional; Region: PRK11462
316401015711	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
316401015712	11 probable transmembrane helices predicted for ETEC3898 by TMHMM2.0 at aa 32-54, 81-100, 115-137, 150-170, 180-202, 232-254, 264-286, 293-315, 320-342, 363-385 and 400-422
316401015713	PS00872 Sodium:galactoside symporter family signature.
316401015714	integrase; Provisional; Region: PRK09692
316401015715	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
316401015716	active site
316401015717	Int/Topo IB signature motif; other site
316401015718	IS2 transposase TnpB; Reviewed; Region: PRK09409
316401015719	HTH-like domain; Region: HTH_21; pfam13276
316401015720	Integrase core domain; Region: rve; pfam00665
316401015721	Integrase core domain; Region: rve_3; pfam13683
316401015722	IS2 repressor TnpA; Reviewed; Region: PRK09413
316401015723	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
316401015724	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
316401015725	TPR motif; other site
316401015726	binding surface
316401015727	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
316401015728	Sulfatase; Region: Sulfatase; pfam00884
316401015729	5 probable transmembrane helices predicted for ETEC3903 by TMHMM2.0 at aa 54-76, 86-108, 137-156, 166-188 and 201-220
316401015730	Dynamin family; Region: Dynamin_N; pfam00350
316401015731	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
316401015732	G1 box; other site
316401015733	GTP/Mg2+ binding site [chemical binding]; other site
316401015734	G2 box; other site
316401015735	Switch I region; other site
316401015736	G3 box; other site
316401015737	Switch II region; other site
316401015738	G4 box; other site
316401015739	PS00017 ATP/GTP-binding site motif A (P-loop).
316401015740	1 probable transmembrane helix predicted for ETEC3905 by TMHMM2.0 at aa 456-478
316401015741	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
316401015742	G1 box; other site
316401015743	GTP/Mg2+ binding site [chemical binding]; other site
316401015744	1 probable transmembrane helix predicted for ETEC3906 by TMHMM2.0 at aa 180-202
316401015745	PS00017 ATP/GTP-binding site motif A (P-loop).
316401015746	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
316401015747	Signal peptide predicted for ETEC3907 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.984 between residues 22 and 23
316401015748	Domain of unknown function (DUF4365); Region: DUF4365; pfam14280
316401015749	AAA domain; Region: AAA_21; pfam13304
316401015750	PS00017 ATP/GTP-binding site motif A (P-loop).
316401015751	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
316401015752	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
316401015753	HsdM N-terminal domain; Region: HsdM_N; pfam12161
316401015754	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
316401015755	Methyltransferase domain; Region: Methyltransf_26; pfam13659
316401015756	PS00092 N-6 Adenine-specific DNA methylases signature.
316401015757	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
316401015758	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
316401015759	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
316401015760	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
316401015761	ATP binding site [chemical binding]; other site
316401015762	putative Mg++ binding site [ion binding]; other site
316401015763	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
316401015764	3 probable transmembrane helices predicted for ETEC3915 by TMHMM2.0 at aa 23-42, 57-74 and 87-109
316401015765	Beta protein; Region: Beta_protein; pfam14350
316401015766	Domain of unknown function (DUF955); Region: DUF955; pfam06114
316401015767	PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.
316401015768	phosphodiesterase; Provisional; Region: PRK12704
316401015769	2 probable transmembrane helices predicted for ETEC3920 by TMHMM2.0 at aa 27-49 and 102-124
316401015770	Similar to C-terminus of Escherichia coli o6:k15:h31 (strain 536/upec). putative phage integrase. UniProt:Q0TBE3 (EMBL:CP000247 (393 aa) fasta scores: E()=4.5e-08, 63.415% id in 41 aa
316401015771	PerC transcriptional activator; Region: PerC; pfam06069
316401015772	PS00017 ATP/GTP-binding site motif A (P-loop).
316401015773	Protein of unknown function (DUF770); Region: DUF770; cl01402
316401015774	ProQ/FINO family; Region: ProQ; pfam04352
316401015775	hypothetical protein; Provisional; Region: PRK13560
316401015776	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
316401015777	Protein of unknown function (DUF3296); Region: DUF3296; pfam11726
316401015778	Predicted GTPase [General function prediction only]; Region: COG3596
316401015779	YfjP GTPase; Region: YfjP; cd11383
316401015780	G1 box; other site
316401015781	GTP/Mg2+ binding site [chemical binding]; other site
316401015782	Switch I region; other site
316401015783	G2 box; other site
316401015784	Switch II region; other site
316401015785	G3 box; other site
316401015786	G4 box; other site
316401015787	G5 box; other site
316401015788	PS00017 ATP/GTP-binding site motif A (P-loop).
316401015789	HTH domain; Region: HTH_11; cl17392
316401015790	WYL domain; Region: WYL; pfam13280
316401015791	Signal peptide predicted for ETEC3942 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.983 between residues 56 and 57
316401015792	Domain of unknown function (DUF932); Region: DUF932; pfam06067
316401015793	Antirestriction protein; Region: Antirestrict; pfam03230
316401015794	PS00294 Prenyl group binding site (CAAX box).
316401015795	DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003
316401015796	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
316401015797	MPN+ (JAMM) motif; other site
316401015798	Zinc-binding site [ion binding]; other site
316401015799	PS01302 DNA repair protein radC family signature.
316401015800	YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154
316401015801	Protein of unknown function (DUF1219); Region: DUF1219; pfam06755
316401015802	Methyltransferase domain; Region: Methyltransf_27; pfam13708
316401015803	sugar efflux transporter; Region: 2A0120; TIGR00899
316401015804	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401015805	putative substrate translocation pore; other site
316401015806	Signal peptide predicted for ETEC3952 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.943 between residues 31 and 32
316401015807	12 probable transmembrane helices predicted for ETEC3952 by TMHMM2.0 at aa 12-34, 49-71, 83-100, 104-121, 141-163, 173-195, 222-244, 254-276, 283-302, 312-331, 351-368 and 372-391
316401015808	EamA-like transporter family; Region: EamA; pfam00892
316401015809	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
316401015810	EamA-like transporter family; Region: EamA; pfam00892
316401015811	Signal peptide predicted for ETEC3953 by SignalP 2.0 HMM (Signal peptide probability 0.969) with cleavage site probability 0.957 between residues 25 and 26
316401015812	10 probable transmembrane helices predicted for ETEC3953 by TMHMM2.0 at aa 7-29, 39-59, 72-94, 98-120, 127-144, 154-176, 183-205, 215-237, 250-272 and 276-293
316401015813	cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861
316401015814	lipoprotein, YaeC family; Region: TIGR00363
316401015815	Signal peptide predicted for ETEC3954 by SignalP 2.0 HMM (Signal peptide probability 0.985) with cleavage site probability 0.659 between residues 27 and 28
316401015816	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401015817	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
316401015818	Signal peptide predicted for ETEC3955 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 21 and 22
316401015819	ribonucleoside transporter; Reviewed; Region: nepI; PRK10213
316401015820	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401015821	putative substrate translocation pore; other site
316401015822	12 probable transmembrane helices predicted for ETEC3956 by TMHMM2.0 at aa 73-95, 110-129, 141-160, 165-187, 200-222, 232-251, 272-294, 309-331, 338-357, 361-383, 396-418 and 422-444
316401015823	Protein of unknown function (DUF1198); Region: DUF1198; pfam06711
316401015824	Signal peptide predicted for ETEC3957 by SignalP 2.0 HMM (Signal peptide probability 0.670) with cleavage site probability 0.403 between residues 21 and 22
316401015825	1 probable transmembrane helix predicted for ETEC3957 by TMHMM2.0 at aa 4-21
316401015826	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
316401015827	13 probable transmembrane helices predicted for ETEC3958 by TMHMM2.0 at aa 31-53, 63-85, 87-109, 114-136, 143-162, 177-199, 206-228, 254-276, 296-318, 324-346, 353-375, 390-412 and 425-443
316401015828	cryptic adenine deaminase; Provisional; Region: PRK10027
316401015829	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
316401015830	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
316401015831	active site
316401015832	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
316401015833	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
316401015834	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401015835	putative substrate translocation pore; other site
316401015836	12 probable transmembrane helices predicted for ETEC3960 by TMHMM2.0 at aa 28-46, 66-88, 97-116, 126-148, 160-182, 192-214, 254-276, 296-318, 325-347, 357-379, 392-411 and 426-445
316401015837	PS00942 glpT family of transporters signature.
316401015838	regulatory protein UhpC; Provisional; Region: PRK11663
316401015839	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401015840	putative substrate translocation pore; other site
316401015841	12 probable transmembrane helices predicted for ETEC3961 by TMHMM2.0 at aa 26-45, 67-89, 96-118, 122-144, 156-178, 183-205, 245-267, 287-309, 322-344, 348-370, 377-399 and 409-431
316401015842	PS00942 glpT family of transporters signature.
316401015843	sensory histidine kinase UhpB; Provisional; Region: PRK11644
316401015844	MASE1; Region: MASE1; pfam05231
316401015845	Histidine kinase; Region: HisKA_3; pfam07730
316401015846	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316401015847	ATP binding site [chemical binding]; other site
316401015848	Mg2+ binding site [ion binding]; other site
316401015849	G-X-G motif; other site
316401015850	7 probable transmembrane helices predicted for ETEC3962 by TMHMM2.0 at aa 7-29, 78-100, 112-131, 141-163, 184-201, 221-243 and 255-274
316401015851	Signal peptide predicted for ETEC3962 by SignalP 2.0 HMM (Signal peptide probability 0.926) with cleavage site probability 0.611 between residues 32 and 33
316401015852	DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360
316401015853	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316401015854	active site
316401015855	phosphorylation site [posttranslational modification]
316401015856	intermolecular recognition site; other site
316401015857	dimerization interface [polypeptide binding]; other site
316401015858	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
316401015859	DNA binding residues [nucleotide binding]
316401015860	dimerization interface [polypeptide binding]; other site
316401015861	PS00622 Bacterial regulatory proteins, luxR family signature.
316401015862	Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440
316401015863	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
316401015864	putative valine binding site [chemical binding]; other site
316401015865	dimer interface [polypeptide binding]; other site
316401015866	acetolactate synthase catalytic subunit; Validated; Region: PRK08155
316401015867	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
316401015868	PYR/PP interface [polypeptide binding]; other site
316401015869	dimer interface [polypeptide binding]; other site
316401015870	TPP binding site [chemical binding]; other site
316401015871	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
316401015872	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
316401015873	TPP-binding site [chemical binding]; other site
316401015874	dimer interface [polypeptide binding]; other site
316401015875	PS00187 Thiamine pyrophosphate enzymes signature.
316401015876	multidrug resistance protein D; Provisional; Region: emrD; PRK11652
316401015877	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401015878	putative substrate translocation pore; other site
316401015879	Signal peptide predicted for ETEC3967 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.994 between residues 23 and 24
316401015880	12 probable transmembrane helices predicted for ETEC3967 by TMHMM2.0 at aa 7-29, 44-66, 75-94, 98-120, 133-155, 165-182, 203-225, 240-262, 275-294, 299-321, 328-350 and 365-384
316401015881	Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641
316401015882	Domain of unknown function (DUF202); Region: DUF202; pfam02656
316401015883	3 probable transmembrane helices predicted for ETEC3969 by TMHMM2.0 at aa 22-39, 49-68 and 91-113
316401015884	Predicted membrane protein [Function unknown]; Region: COG2149
316401015885	3 probable transmembrane helices predicted for ETEC3970 by TMHMM2.0 at aa 21-40, 50-72 and 92-114
316401015886	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
316401015887	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
316401015888	Probable transposase; Region: OrfB_IS605; pfam01385
316401015889	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
316401015890	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
316401015891	Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298
316401015892	NAD binding site [chemical binding]; other site
316401015893	sugar binding site [chemical binding]; other site
316401015894	divalent metal binding site [ion binding]; other site
316401015895	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
316401015896	dimer interface [polypeptide binding]; other site
316401015897	PS01324 Glycosyl hydrolases family 4 signature.
316401015898	1 probable transmembrane helix predicted for ETEC3972 by TMHMM2.0 at aa 5-27
316401015899	PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005
316401015900	PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852
316401015901	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
316401015902	active site turn [active]
316401015903	phosphorylation site [posttranslational modification]
316401015904	PS01035 PTS EIIB domains cysteine phosphorylation site signature.
316401015905	11 probable transmembrane helices predicted for ETEC3973 by TMHMM2.0 at aa 10-32, 91-113, 128-150, 162-184, 199-221, 233-255, 278-300, 307-324, 329-346, 353-372 and 387-409
316401015906	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
316401015907	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
316401015908	DNA-binding site [nucleotide binding]; DNA binding site
316401015909	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
316401015910	PS00043 Bacterial regulatory proteins, gntR family signature.
316401015911	putative transporter; Validated; Region: PRK03818
316401015912	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
316401015913	TrkA-C domain; Region: TrkA_C; pfam02080
316401015914	TrkA-C domain; Region: TrkA_C; pfam02080
316401015915	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
316401015916	10 probable transmembrane helices predicted for ETEC3975 by TMHMM2.0 at aa 4-22, 29-51, 61-83, 90-112, 160-182, 371-393, 403-425, 437-459, 463-485 and 530-552
316401015917	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
316401015918	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
316401015919	putative dimer interface [polypeptide binding]; other site
316401015920	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
316401015921	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
316401015922	putative dimer interface [polypeptide binding]; other site
316401015923	hypothetical protein; Provisional; Region: PRK11616
316401015924	Signal peptide predicted for ETEC3978 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.973 between residues 26 and 27
316401015925	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401015926	Protein of unknown function (DUF3748); Region: DUF3748; pfam12566
316401015927	putative oxidoreductase; Provisional; Region: PRK11445
316401015928	hypothetical protein; Provisional; Region: PRK07236
316401015929	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401015930	D-galactonate transporter; Region: 2A0114; TIGR00893
316401015931	putative substrate translocation pore; other site
316401015932	11 probable transmembrane helices predicted for ETEC3981 by TMHMM2.0 at aa 15-32, 53-75, 85-107, 141-163, 167-188, 242-263, 278-300, 307-329, 339-361, 374-396 and 401-423
316401015933	galactonate dehydratase; Provisional; Region: PRK14017
316401015934	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
316401015935	putative active site pocket [active]
316401015936	putative metal binding site [ion binding]; other site
316401015937	PS00909 Mandelate racemase / muconate lactonizing enzyme family signature 2.
316401015938	PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1.
316401015939	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
316401015940	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
316401015941	active site
316401015942	intersubunit interface [polypeptide binding]; other site
316401015943	catalytic residue [active]
316401015944	PS00606 Beta-ketoacyl synthases active site.
316401015945	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
316401015946	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
316401015947	PS00761 Signal peptidases I signature 3.
316401015948	Transcriptional regulators [Transcription]; Region: FadR; COG2186
316401015949	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
316401015950	DNA-binding site [nucleotide binding]; DNA binding site
316401015951	FCD domain; Region: FCD; pfam07729
316401015952	PS00043 Bacterial regulatory proteins, gntR family signature.
316401015953	hypothetical protein; Provisional; Region: PRK10215
316401015954	Signal peptide predicted for ETEC3986 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.471 between residues 28 and 29
316401015955	1 probable transmembrane helix predicted for ETEC3986 by TMHMM2.0 at aa 7-29
316401015956	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401015957	PS00290 Immunoglobulins and major histocompatibility complex proteins signature.
316401015958	sugar phosphate phosphatase; Provisional; Region: PRK10513
316401015959	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
316401015960	active site
316401015961	motif I; other site
316401015962	motif II; other site
316401015963	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
316401015964	PS01229 Hypothetical cof family signature 2.
316401015965	PS01228 Hypothetical cof family signature 1.
316401015966	hypothetical protein; Provisional; Region: PRK11426
316401015967	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
316401015968	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316401015969	Mg2+ binding site [ion binding]; other site
316401015970	G-X-G motif; other site
316401015971	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
316401015972	anchoring element; other site
316401015973	dimer interface [polypeptide binding]; other site
316401015974	ATP binding site [chemical binding]; other site
316401015975	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
316401015976	active site
316401015977	putative metal-binding site [ion binding]; other site
316401015978	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
316401015979	PS00177 DNA topoisomerase II signature.
316401015980	recF protein; Region: recf; TIGR00611
316401015981	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316401015982	Walker A/P-loop; other site
316401015983	ATP binding site [chemical binding]; other site
316401015984	Q-loop/lid; other site
316401015985	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316401015986	ABC transporter signature motif; other site
316401015987	Walker B; other site
316401015988	D-loop; other site
316401015989	H-loop/switch region; other site
316401015990	PS00618 RecF protein signature 2.
316401015991	PS00617 RecF protein signature 1.
316401015992	PS00017 ATP/GTP-binding site motif A (P-loop).
316401015993	DNA polymerase III subunit beta; Validated; Region: PRK05643
316401015994	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
316401015995	putative DNA binding surface [nucleotide binding]; other site
316401015996	dimer interface [polypeptide binding]; other site
316401015997	beta-clamp/clamp loader binding surface; other site
316401015998	beta-clamp/translesion DNA polymerase binding surface; other site
316401015999	DnaA N-terminal domain; Region: DnaA_N; pfam11638
316401016000	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
316401016001	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316401016002	Walker A motif; other site
316401016003	ATP binding site [chemical binding]; other site
316401016004	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
316401016005	Walker B motif; other site
316401016006	arginine finger; other site
316401016007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
316401016008	DnaA box-binding interface [nucleotide binding]; other site
316401016009	PS01008 DnaA protein signature.
316401016010	PS00017 ATP/GTP-binding site motif A (P-loop).
316401016011	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
316401016012	PS00784 Ribosomal protein L34 signature.
316401016013	ribonuclease P; Reviewed; Region: rnpA; PRK01732
316401016014	PS00648 Bacterial ribonuclease P protein component signature.
316401016015	hypothetical protein; Validated; Region: PRK00041
316401016016	membrane protein insertase; Provisional; Region: PRK01318
316401016017	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
316401016018	Signal peptide predicted for ETEC3996 by SignalP 2.0 HMM (Signal peptide probability 0.983) with cleavage site probability 0.707 between residues 24 and 25
316401016019	4 probable transmembrane helices predicted for ETEC3996 by TMHMM2.0 at aa 7-24, 346-368, 419-441 and 497-519
316401016020	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
316401016021	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
316401016022	trmE is a tRNA modification GTPase; Region: trmE; cd04164
316401016023	G1 box; other site
316401016024	GTP/Mg2+ binding site [chemical binding]; other site
316401016025	Switch I region; other site
316401016026	G2 box; other site
316401016027	Switch II region; other site
316401016028	G3 box; other site
316401016029	G4 box; other site
316401016030	G5 box; other site
316401016031	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
316401016032	PS00017 ATP/GTP-binding site motif A (P-loop).
316401016033	Tryptophanese operon leader peptide; Region: Tna_leader; pfam08053
316401016034	tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617
316401016035	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
316401016036	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
316401016037	catalytic residue [active]
316401016038	PS00853 Beta-eliminating lyases pyridoxal-phosphate attachment site.
316401016039	tryptophan permease TnaB; Provisional; Region: PRK09664
316401016040	aromatic amino acid transport protein; Region: araaP; TIGR00837
316401016041	11 probable transmembrane helices predicted for ETEC4000 by TMHMM2.0 at aa 12-34, 39-61, 82-104, 124-146, 153-175, 195-217, 230-252, 285-307, 320-342, 347-369 and 382-404
316401016042	PS00594 Aromatic amino acids permeases signature.
316401016043	multidrug efflux system protein MdtL; Provisional; Region: PRK10473
316401016044	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401016045	putative substrate translocation pore; other site
316401016046	11 probable transmembrane helices predicted for ETEC4001 by TMHMM2.0 at aa 5-24, 39-61, 68-90, 94-116, 129-151, 156-178, 203-222, 242-264, 276-309, 324-346 and 353-375
316401016047	DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216
316401016048	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401016049	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
316401016050	substrate binding pocket [chemical binding]; other site
316401016051	dimerization interface [polypeptide binding]; other site
316401016052	PS00044 Bacterial regulatory proteins, lysR family signature.
316401016053	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
316401016054	Predicted flavoprotein [General function prediction only]; Region: COG0431
316401016055	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
316401016056	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
316401016057	13 probable transmembrane helices predicted for ETEC4005 by TMHMM2.0 at aa 30-52, 62-84, 86-108, 113-135, 142-161, 176-198, 205-222, 253-275, 295-317, 327-349, 356-374, 389-411 and 424-442
316401016058	PS00267 Tachykinin family signature.
316401016059	6-phosphogluconate phosphatase; Provisional; Region: PRK10563
316401016060	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
316401016061	active site
316401016062	motif I; other site
316401016063	motif II; other site
316401016064	putative inner membrane protein; Provisional; Region: PRK09823
316401016065	4 probable transmembrane helices predicted for ETEC4007 by TMHMM2.0 at aa 12-31, 41-63, 84-106 and 121-140
316401016066	Uncharacterized protein family (UPF0167); Region: UPF0167; cl01252
316401016067	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
316401016068	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
316401016069	active site
316401016070	trimer interface [polypeptide binding]; other site
316401016071	allosteric site; other site
316401016072	active site lid [active]
316401016073	PS01161 Glucosamine/galactosamine-6-phosphate isomerases signature.
316401016074	N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294
316401016075	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
316401016076	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
316401016077	Signal peptide predicted for ETEC4010 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.767 between residues 32 and 33
316401016078	Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471
316401016079	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
316401016080	trimer interface; other site
316401016081	sugar binding site [chemical binding]; other site
316401016082	Signal peptide predicted for ETEC4011 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.987 between residues 25 and 26
316401016083	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
316401016084	beta-galactosidase; Region: BGL; TIGR03356
316401016085	PS00572 Glycosyl hydrolases family 1 active site.
316401016086	PS00653 Glycosyl hydrolases family 1 N-terminal signature.
316401016087	PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824
316401016088	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
316401016089	active site turn [active]
316401016090	phosphorylation site [posttranslational modification]
316401016091	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
316401016092	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
316401016093	HPr interaction site; other site
316401016094	glycerol kinase (GK) interaction site [polypeptide binding]; other site
316401016095	active site
316401016096	phosphorylation site [posttranslational modification]
316401016097	PS00371 PTS EIIA domains phosphorylation site signature 1.
316401016098	10 probable transmembrane helices predicted for ETEC4013 by TMHMM2.0 at aa 100-119, 139-161, 168-190, 205-227, 234-256, 260-282, 287-309, 324-346, 381-400 and 426-448
316401016099	PS01035 PTS EIIB domains cysteine phosphorylation site signature.
316401016100	transcriptional antiterminator BglG; Provisional; Region: PRK09772
316401016101	CAT RNA binding domain; Region: CAT_RBD; pfam03123
316401016102	PRD domain; Region: PRD; pfam00874
316401016103	PRD domain; Region: PRD; pfam00874
316401016104	PS00654 Transcriptional antiterminators bglG family signature.
316401016105	transcriptional regulator PhoU; Provisional; Region: PRK11115
316401016106	PhoU domain; Region: PhoU; pfam01895
316401016107	PhoU domain; Region: PhoU; pfam01895
316401016108	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
316401016109	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
316401016110	Walker A/P-loop; other site
316401016111	ATP binding site [chemical binding]; other site
316401016112	Q-loop/lid; other site
316401016113	ABC transporter signature motif; other site
316401016114	Walker B; other site
316401016115	D-loop; other site
316401016116	H-loop/switch region; other site
316401016117	PS00211 ABC transporters family signature.
316401016118	PS00017 ATP/GTP-binding site motif A (P-loop).
316401016119	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
316401016120	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401016121	dimer interface [polypeptide binding]; other site
316401016122	conserved gate region; other site
316401016123	putative PBP binding loops; other site
316401016124	ABC-ATPase subunit interface; other site
316401016125	6 probable transmembrane helices predicted for ETEC4017 by TMHMM2.0 at aa 29-51, 88-110, 123-145, 150-169, 201-223 and 268-290
316401016126	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
316401016127	phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275
316401016128	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401016129	dimer interface [polypeptide binding]; other site
316401016130	conserved gate region; other site
316401016131	putative PBP binding loops; other site
316401016132	ABC-ATPase subunit interface; other site
316401016133	6 probable transmembrane helices predicted for ETEC4018 by TMHMM2.0 at aa 21-43, 78-100, 112-134, 166-188, 227-249 and 282-304
316401016134	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
316401016135	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
316401016136	1 probable transmembrane helix predicted for ETEC4019 by TMHMM2.0 at aa 7-29
316401016137	Signal peptide predicted for ETEC4019 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.946 between residues 25 and 26
316401016138	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
316401016139	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
316401016140	glutaminase active site [active]
316401016141	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
316401016142	dimer interface [polypeptide binding]; other site
316401016143	active site
316401016144	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
316401016145	dimer interface [polypeptide binding]; other site
316401016146	active site
316401016147	PS00443 Glutamine amidotransferases class-II active site.
316401016148	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451
316401016149	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
316401016150	Substrate binding site; other site
316401016151	Mg++ binding site; other site
316401016152	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
316401016153	active site
316401016154	substrate binding site [chemical binding]; other site
316401016155	CoA binding site [chemical binding]; other site
316401016156	PS00101 Hexapeptide-repeat containing-transferases signature.
316401016157	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
316401016158	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
316401016159	gamma subunit interface [polypeptide binding]; other site
316401016160	epsilon subunit interface [polypeptide binding]; other site
316401016161	LBP interface [polypeptide binding]; other site
316401016162	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
316401016163	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
316401016164	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
316401016165	alpha subunit interaction interface [polypeptide binding]; other site
316401016166	Walker A motif; other site
316401016167	ATP binding site [chemical binding]; other site
316401016168	Walker B motif; other site
316401016169	inhibitor binding site; inhibition site
316401016170	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
316401016171	PS00152 ATP synthase alpha and beta subunits signature.
316401016172	PS00017 ATP/GTP-binding site motif A (P-loop).
316401016173	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
316401016174	core domain interface [polypeptide binding]; other site
316401016175	delta subunit interface [polypeptide binding]; other site
316401016176	epsilon subunit interface [polypeptide binding]; other site
316401016177	PS00153 ATP synthase gamma subunit signature.
316401016178	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
316401016179	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
316401016180	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
316401016181	beta subunit interaction interface [polypeptide binding]; other site
316401016182	Walker A motif; other site
316401016183	ATP binding site [chemical binding]; other site
316401016184	Walker B motif; other site
316401016185	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
316401016186	PS00152 ATP synthase alpha and beta subunits signature.
316401016187	PS00017 ATP/GTP-binding site motif A (P-loop).
316401016188	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
316401016189	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
316401016190	PS00389 ATP synthase delta (OSCP) subunit signature.
316401016191	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
316401016192	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
316401016193	1 probable transmembrane helix predicted for ETEC4027 by TMHMM2.0 at aa 5-27
316401016194	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
316401016195	2 probable transmembrane helices predicted for ETEC4028 by TMHMM2.0 at aa 10-32 and 53-75
316401016196	PS00605 ATP synthase c subunit signature.
316401016197	Signal peptide predicted for ETEC4028 by SignalP 2.0 HMM (Signal peptide probability 0.732) with cleavage site probability 0.548 between residues 23 and 24
316401016198	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
316401016199	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
316401016200	5 probable transmembrane helices predicted for ETEC4029 by TMHMM2.0 at aa 38-60, 100-122, 147-166, 211-233 and 243-265
316401016201	PS00449 ATP synthase a subunit signature.
316401016202	F0F1 ATP synthase subunit I; Validated; Region: PRK08049
316401016203	4 probable transmembrane helices predicted for ETEC4030 by TMHMM2.0 at aa 10-29, 36-58, 73-95 and 100-122
316401016204	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
316401016205	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316401016206	S-adenosylmethionine binding site [chemical binding]; other site
316401016207	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
316401016208	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
316401016209	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
316401016210	PS01281 Glucose inhibited division protein A family signature 2.
316401016211	PS01280 Glucose inhibited division protein A family signature 1.
316401016212	FMN-binding protein MioC; Provisional; Region: PRK09004
316401016213	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
316401016214	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
316401016215	putative DNA binding site [nucleotide binding]; other site
316401016216	putative Zn2+ binding site [ion binding]; other site
316401016217	AsnC family; Region: AsnC_trans_reg; pfam01037
316401016218	PS00519 Bacterial regulatory proteins, asnC family signature.
316401016219	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
316401016220	dimer interface [polypeptide binding]; other site
316401016221	active site
316401016222	hypothetical protein; Provisional; Region: yieM; PRK10997
316401016223	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
316401016224	metal ion-dependent adhesion site (MIDAS); other site
316401016225	regulatory ATPase RavA; Provisional; Region: PRK13531
316401016226	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316401016227	Walker A motif; other site
316401016228	ATP binding site [chemical binding]; other site
316401016229	Walker B motif; other site
316401016230	arginine finger; other site
316401016231	Protein of unknown function (DUF3763); Region: DUF3763; pfam12592
316401016232	potassium transport protein Kup; Provisional; Region: trkD; PRK10745
316401016233	potassium uptake protein; Region: kup; TIGR00794
316401016234	Signal peptide predicted for ETEC4038 by SignalP 2.0 HMM (Signal peptide probability 0.744) with cleavage site probability 0.744 between residues 22 and 23
316401016235	12 probable transmembrane helices predicted for ETEC4038 by TMHMM2.0 at aa 7-29, 49-71, 102-124, 134-156, 168-190, 210-232, 245-267, 287-309, 335-357, 363-385, 392-414 and 419-441
316401016236	D-ribose pyranase; Provisional; Region: PRK11797
316401016237	D-ribose transporter ATP binding protein; Provisional; Region: PRK10762
316401016238	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
316401016239	Walker A/P-loop; other site
316401016240	ATP binding site [chemical binding]; other site
316401016241	Q-loop/lid; other site
316401016242	ABC transporter signature motif; other site
316401016243	Walker B; other site
316401016244	D-loop; other site
316401016245	H-loop/switch region; other site
316401016246	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
316401016247	PS00017 ATP/GTP-binding site motif A (P-loop).
316401016248	PS00211 ABC transporters family signature.
316401016249	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
316401016250	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
316401016251	TM-ABC transporter signature motif; other site
316401016252	8 probable transmembrane helices predicted for ETEC4041 by TMHMM2.0 at aa 21-43, 53-72, 74-93, 97-119, 126-145, 165-187, 221-243 and 275-297
316401016253	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
316401016254	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
316401016255	ligand binding site [chemical binding]; other site
316401016256	dimerization interface [polypeptide binding]; other site
316401016257	Signal peptide predicted for ETEC4042 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.949 between residues 25 and 26
316401016258	PS00017 ATP/GTP-binding site motif A (P-loop).
316401016259	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
316401016260	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
316401016261	substrate binding site [chemical binding]; other site
316401016262	dimer interface [polypeptide binding]; other site
316401016263	ATP binding site [chemical binding]; other site
316401016264	PS00583 pfkB family of carbohydrate kinases signature 1.
316401016265	PS00584 pfkB family of carbohydrate kinases signature 2.
316401016266	transcriptional repressor RbsR; Provisional; Region: PRK10423
316401016267	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
316401016268	DNA binding site [nucleotide binding]
316401016269	domain linker motif; other site
316401016270	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
316401016271	dimerization interface [polypeptide binding]; other site
316401016272	ligand binding site [chemical binding]; other site
316401016273	PS00356 Bacterial regulatory proteins, lacI family signature.
316401016274	putative transporter; Provisional; Region: PRK10504
316401016275	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401016276	putative substrate translocation pore; other site
316401016277	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401016278	14 probable transmembrane helices predicted for ETEC4045 by TMHMM2.0 at aa 11-33, 48-70, 77-99, 103-125, 137-159, 164-183, 196-218, 222-244, 264-286, 291-313, 325-347, 351-373, 394-416 and 431-450
316401016279	Signal peptide predicted for ETEC4045 by SignalP 2.0 HMM (Signal peptide probability 0.991) with cleavage site probability 0.951 between residues 27 and 28
316401016280	Transcriptional regulators [Transcription]; Region: FadR; COG2186
316401016281	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
316401016282	DNA-binding site [nucleotide binding]; DNA binding site
316401016283	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
316401016284	PS00043 Bacterial regulatory proteins, gntR family signature.
316401016285	transcriptional regulator HdfR; Provisional; Region: PRK03601
316401016286	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401016287	LysR substrate binding domain; Region: LysR_substrate; pfam03466
316401016288	dimerization interface [polypeptide binding]; other site
316401016289	PS00044 Bacterial regulatory proteins, lysR family signature.
316401016290	hypothetical protein; Provisional; Region: PRK11027
316401016291	putative ATP-dependent protease; Provisional; Region: PRK09862
316401016292	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
316401016293	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316401016294	Walker A motif; other site
316401016295	ATP binding site [chemical binding]; other site
316401016296	Walker B motif; other site
316401016297	arginine finger; other site
316401016298	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
316401016299	PS00017 ATP/GTP-binding site motif A (P-loop).
316401016300	ilvG operon leader peptide; Provisional; Region: PRK10424
316401016301	Signal peptide predicted for ETEC4050 by SignalP 2.0 HMM (Signal peptide probability 0.845) with cleavage site probability 0.822 between residues 25 and 26
316401016302	1 probable transmembrane helix predicted for ETEC4050 by TMHMM2.0 at aa 7-29
316401016303	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
316401016304	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
316401016305	PYR/PP interface [polypeptide binding]; other site
316401016306	dimer interface [polypeptide binding]; other site
316401016307	TPP binding site [chemical binding]; other site
316401016308	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
316401016309	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
316401016310	TPP-binding site [chemical binding]; other site
316401016311	dimer interface [polypeptide binding]; other site
316401016312	PS00044 Bacterial regulatory proteins, lysR family signature.
316401016313	PS00187 Thiamine pyrophosphate enzymes signature.
316401016314	acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152
316401016315	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
316401016316	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
316401016317	homodimer interface [polypeptide binding]; other site
316401016318	substrate-cofactor binding pocket; other site
316401016319	catalytic residue [active]
316401016320	PS00770 Aminotransferases class-IV signature.
316401016321	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
316401016322	PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1.
316401016323	PS00017 ATP/GTP-binding site motif A (P-loop).
316401016324	PS00887 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 2.
316401016325	threonine dehydratase; Reviewed; Region: PRK09224
316401016326	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
316401016327	tetramer interface [polypeptide binding]; other site
316401016328	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316401016329	catalytic residue [active]
316401016330	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
316401016331	putative Ile/Val binding site [chemical binding]; other site
316401016332	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
316401016333	putative Ile/Val binding site [chemical binding]; other site
316401016334	PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site.
316401016335	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401016336	DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716
316401016337	The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430
316401016338	putative dimerization interface [polypeptide binding]; other site
316401016339	PS00044 Bacterial regulatory proteins, lysR family signature.
316401016340	ketol-acid reductoisomerase; Validated; Region: PRK05225
316401016341	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
316401016342	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
316401016343	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
316401016344	peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441
316401016345	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
316401016346	PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature.
316401016347	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3692
316401016348	PS00215 Mitochondrial energy transfer proteins signature.
316401016349	ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919
316401016350	Part of AAA domain; Region: AAA_19; pfam13245
316401016351	Family description; Region: UvrD_C_2; pfam13538
316401016352	PS00017 ATP/GTP-binding site motif A (P-loop).
316401016353	guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031
316401016354	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
316401016355	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
316401016356	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
316401016357	ATP binding site [chemical binding]; other site
316401016358	Mg++ binding site [ion binding]; other site
316401016359	motif III; other site
316401016360	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
316401016361	nucleotide binding region [chemical binding]; other site
316401016362	ATP-binding site [chemical binding]; other site
316401016363	PS00039 DEAD-box subfamily ATP-dependent helicases signature.
316401016364	PS00017 ATP/GTP-binding site motif A (P-loop).
316401016365	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
316401016366	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
316401016367	catalytic residues [active]
316401016368	PS00194 Thioredoxin family active site.
316401016369	putative rho operon leader peptide; Provisional; Region: PRK09979
316401016370	transcription termination factor Rho; Provisional; Region: rho; PRK09376
316401016371	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
316401016372	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
316401016373	RNA binding site [nucleotide binding]; other site
316401016374	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
316401016375	multimer interface [polypeptide binding]; other site
316401016376	Walker A motif; other site
316401016377	ATP binding site [chemical binding]; other site
316401016378	Walker B motif; other site
316401016379	PS00464 Ribosomal protein L22 signature.
316401016380	PS00017 ATP/GTP-binding site motif A (P-loop).
316401016381	undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119
316401016382	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
316401016383	Mg++ binding site [ion binding]; other site
316401016384	putative catalytic motif [active]
316401016385	substrate binding site [chemical binding]; other site
316401016386	11 probable transmembrane helices predicted for ETEC4066 by TMHMM2.0 at aa 5-24, 45-66, 70-89, 105-127, 131-153, 160-179, 184-206, 213-232, 242-261, 294-311 and 321-338
316401016387	lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638
316401016388	Chain length determinant protein; Region: Wzz; pfam02706
316401016389	2 probable transmembrane helices predicted for ETEC4067 by TMHMM2.0 at aa 29-51 and 323-342
316401016390	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
316401016391	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
316401016392	active site
316401016393	homodimer interface [polypeptide binding]; other site
316401016394	UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064
316401016395	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
316401016396	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
316401016397	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
316401016398	Signal peptide predicted for ETEC4069 by SignalP 2.0 HMM (Signal peptide probability 0.879) with cleavage site probability 0.783 between residues 23 and 24
316401016399	PS00678 Trp-Asp (WD) repeats signature.
316401016400	dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217
316401016401	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
316401016402	NAD binding site [chemical binding]; other site
316401016403	substrate binding site [chemical binding]; other site
316401016404	homodimer interface [polypeptide binding]; other site
316401016405	active site
316401016406	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
316401016407	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
316401016408	substrate binding site; other site
316401016409	tetramer interface; other site
316401016410	TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975
316401016411	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
316401016412	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
316401016413	inhibitor-cofactor binding pocket; inhibition site
316401016414	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316401016415	catalytic residue [active]
316401016416	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
316401016417	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125
316401016418	12 probable transmembrane helices predicted for ETEC4074 by TMHMM2.0 at aa 13-35, 45-67, 79-101, 116-138, 145-167, 177-199, 220-238, 253-275, 296-318, 333-355, 362-384 and 390-412
316401016419	4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429
316401016420	putative common antigen polymerase; Provisional; Region: PRK02975
316401016421	11 probable transmembrane helices predicted for ETEC4076 by TMHMM2.0 at aa 4-26, 33-55, 70-89, 116-138, 153-175, 182-201, 205-224, 226-245, 338-360, 381-398 and 408-430
316401016422	PS00225 Crystallins beta and gamma 'Greek key' motif signature.
316401016423	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
316401016424	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
316401016425	putative transport protein YifK; Provisional; Region: PRK10746
316401016426	12 probable transmembrane helices predicted for ETEC4078 by TMHMM2.0 at aa 19-36, 40-59, 93-115, 125-147, 154-176, 191-213, 240-262, 277-299, 331-353, 358-380, 401-423 and 428-450
316401016427	PS00218 Amino acid permeases signature.
316401016428	PS00639 Eukaryotic thiol (cysteine) proteases histidine active site.
316401016429	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
316401016430	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316401016431	FeS/SAM binding site; other site
316401016432	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
316401016434	putative protoheme IX biogenesis protein; Provisional; Region: PRK10747
316401016435	HemY protein N-terminus; Region: HemY_N; pfam07219
316401016436	PS00215 Mitochondrial energy transfer proteins signature.
316401016437	2 probable transmembrane helices predicted for ETEC4081 by TMHMM2.0 at aa 5-27 and 40-62
316401016438	Signal peptide predicted for ETEC4081 by SignalP 2.0 HMM (Signal peptide probability 0.725) with cleavage site probability 0.660 between residues 23 and 24
316401016439	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959
316401016440	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
316401016441	1 probable transmembrane helix predicted for ETEC4082 by TMHMM2.0 at aa 36-58
316401016442	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
316401016443	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
316401016444	active site
316401016445	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
316401016446	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
316401016447	domain interfaces; other site
316401016448	active site
316401016449	PS00533 Porphobilinogen deaminase cofactor-binding site.
316401016450	Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072
316401016451	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
316401016452	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
316401016453	PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide.
316401016454	PS01092 Adenylate cyclases class-I signature 1.
316401016455	PS01093 Adenylate cyclases class-I signature 2.
316401016456	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503
316401016457	putative iron binding site [ion binding]; other site
316401016458	Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567
316401016459	Signal peptide predicted for ETEC4087 by SignalP 2.0 HMM (Signal peptide probability 0.849) with cleavage site probability 0.413 between residues 23 and 24
316401016460	1 probable transmembrane helix predicted for ETEC4087 by TMHMM2.0 at aa 7-29
316401016461	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401016462	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
316401016463	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
316401016464	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
316401016465	PS01326 Diaminopimelate epimerase signature.
316401016466	hypothetical protein; Provisional; Region: PRK10963
316401016467	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
316401016468	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
316401016469	active site
316401016470	DNA binding site [nucleotide binding]
316401016471	Int/Topo IB signature motif; other site
316401016472	flavin mononucleotide phosphatase; Provisional; Region: PRK10748
316401016473	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
316401016474	motif II; other site
316401016475	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
316401016476	Part of AAA domain; Region: AAA_19; pfam13245
316401016477	Family description; Region: UvrD_C_2; pfam13538
316401016478	PS00017 ATP/GTP-binding site motif A (P-loop).
316401016479	Predicted periplasmic protein [Function unknown]; Region: COG3698
316401016480	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
316401016481	Signal peptide predicted for ETEC4093 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.777 between residues 32 and 33
316401016482	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
316401016483	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
316401016484	Cl binding site [ion binding]; other site
316401016485	oligomer interface [polypeptide binding]; other site
316401016486	2 probable transmembrane helices predicted for ETEC4094 by TMHMM2.0 at aa 255-273 and 288-310
316401016487	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
316401016488	2 probable transmembrane helices predicted for ETEC4095 by TMHMM2.0 at aa 50-72 and 76-107
316401016489	PS00225 Crystallins beta and gamma 'Greek key' motif signature.
316401016490	hypothetical protein; Provisional; Region: PRK11371
316401016491	4 probable transmembrane helices predicted for ETEC4096 by TMHMM2.0 at aa 19-36, 40-57, 69-91 and 101-120
316401016492	putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430
316401016493	EamA-like transporter family; Region: EamA; cl17759
316401016494	10 probable transmembrane helices predicted for ETEC4097 by TMHMM2.0 at aa 12-34, 38-60, 73-95, 100-122, 129-146, 150-167, 180-197, 212-234, 239-261 and 271-290
316401016495	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
316401016496	CoenzymeA binding site [chemical binding]; other site
316401016497	subunit interaction site [polypeptide binding]; other site
316401016498	PHB binding site; other site
316401016499	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
316401016500	dimerization interface [polypeptide binding]; other site
316401016501	substrate binding site [chemical binding]; other site
316401016502	active site
316401016503	calcium binding site [ion binding]; other site
316401016504	Signal peptide predicted for ETEC4099 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.991 between residues 20 and 21
316401016505	ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057
316401016506	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
316401016507	ATP binding site [chemical binding]; other site
316401016508	putative Mg++ binding site [ion binding]; other site
316401016509	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
316401016510	nucleotide binding region [chemical binding]; other site
316401016511	ATP-binding site [chemical binding]; other site
316401016512	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
316401016513	Helicase and RNase D C-terminal; Region: HRDC; smart00341
316401016514	threonine efflux system; Provisional; Region: PRK10229
316401016515	6 probable transmembrane helices predicted for ETEC4101 by TMHMM2.0 at aa 5-27, 40-62, 67-86, 119-141, 151-173 and 186-205
316401016517	lysophospholipase L2; Provisional; Region: PRK10749
316401016518	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
316401016519	putative hydrolase; Provisional; Region: PRK10976
316401016520	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
316401016521	active site
316401016522	motif I; other site
316401016523	motif II; other site
316401016524	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
316401016525	PS01228 Hypothetical cof family signature 1.
316401016526	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
316401016527	EamA-like transporter family; Region: EamA; pfam00892
316401016528	10 probable transmembrane helices predicted for ETEC4104 by TMHMM2.0 at aa 2-24, 28-47, 54-76, 80-102, 109-128, 138-157, 170-192, 202-224, 231-253 and 258-275
316401016529	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
316401016530	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401016531	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
316401016532	putative dimerization interface [polypeptide binding]; other site
316401016533	PS00044 Bacterial regulatory proteins, lysR family signature.
316401016534	Signal peptide predicted for ETEC4105 by SignalP 2.0 HMM (Signal peptide probability 0.870) with cleavage site probability 0.528 between residues 34 and 35
316401016535	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
316401016536	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
316401016537	THF binding site; other site
316401016538	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
316401016539	substrate binding site [chemical binding]; other site
316401016540	THF binding site; other site
316401016541	zinc-binding site [ion binding]; other site
316401016542	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
316401016543	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
316401016544	uridine phosphorylase; Provisional; Region: PRK11178
316401016545	uridine phosphorylase; Region: Uridine-psphlse; TIGR01718
316401016546	PS01232 Purine and other phosphorylases family 1 signature.
316401016547	DNA recombination protein RmuC; Provisional; Region: PRK10361
316401016548	RmuC family; Region: RmuC; pfam02646
316401016549	Signal peptide predicted for ETEC4109 by SignalP 2.0 HMM (Signal peptide probability 0.972) with cleavage site probability 0.967 between residues 28 and 29
316401016550	1 probable transmembrane helix predicted for ETEC4109 by TMHMM2.0 at aa 5-24
316401016551	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
316401016552	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316401016553	S-adenosylmethionine binding site [chemical binding]; other site
316401016554	PS01183 ubiE/COQ5 methyltransferase family signature 1.
316401016555	PS01184 ubiE/COQ5 methyltransferase family signature 2.
316401016556	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
316401016557	SCP-2 sterol transfer family; Region: SCP2; pfam02036
316401016558	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
316401016559	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
316401016560	2 probable transmembrane helices predicted for ETEC4112 by TMHMM2.0 at aa 501-518 and 523-542
316401016561	twin arginine translocase protein A; Provisional; Region: tatA; PRK03554
316401016562	1 probable transmembrane helix predicted for ETEC4113 by TMHMM2.0 at aa 4-21
316401016563	sec-independent translocase; Provisional; Region: PRK01770
316401016564	sec-independent translocase; Provisional; Region: tatB; PRK00404
316401016565	1 probable transmembrane helix predicted for ETEC4114 by TMHMM2.0 at aa 4-21
316401016566	twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921
316401016567	6 probable transmembrane helices predicted for ETEC4115 by TMHMM2.0 at aa 20-42, 74-96, 116-138, 158-180, 193-210 and 215-237
316401016568	PS01218 Uncharacterized protein family UPF0032 signature.
316401016569	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
316401016570	active site
316401016571	PS01090 Uncharacterized protein family UPF0006 signature 2.
316401016572	PS01091 Uncharacterized protein family UPF0006 signature 3.
316401016573	transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014
316401016574	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892
316401016575	KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354
316401016576	3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922
316401016577	PS00017 ATP/GTP-binding site motif A (P-loop).
316401016578	FMN reductase; Validated; Region: fre; PRK08051
316401016579	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
316401016580	FAD binding pocket [chemical binding]; other site
316401016581	FAD binding motif [chemical binding]; other site
316401016582	phosphate binding motif [ion binding]; other site
316401016583	beta-alpha-beta structure motif; other site
316401016584	NAD binding pocket [chemical binding]; other site
316401016585	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
316401016586	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
316401016587	dimer interface [polypeptide binding]; other site
316401016588	active site
316401016589	PS00099 Thiolases active site.
316401016590	PS00737 Thiolases signature 2.
316401016591	PS00178 Aminoacyl-transfer RNA synthetases class-I signature.
316401016592	PS00098 Thiolases acyl-enzyme intermediate signature.
316401016593	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
316401016594	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
316401016595	substrate binding site [chemical binding]; other site
316401016596	oxyanion hole (OAH) forming residues; other site
316401016597	trimer interface [polypeptide binding]; other site
316401016598	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
316401016599	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
316401016600	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
316401016601	PS00067 3-hydroxyacyl-CoA dehydrogenase signature.
316401016602	PS00166 Enoyl-CoA hydratase/isomerase signature.
316401016603	proline dipeptidase; Provisional; Region: PRK13607
316401016604	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
316401016605	active site
316401016606	PS00491 Aminopeptidase P and proline dipeptidase signature.
316401016607	hypothetical protein; Provisional; Region: PRK11568
316401016608	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
316401016609	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
316401016610	PS00910 Uncharacterized protein family UPF0029 signature.
316401016611	potassium transporter; Provisional; Region: PRK10750
316401016612	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
316401016613	10 probable transmembrane helices predicted for ETEC4124 by TMHMM2.0 at aa 9-31, 35-57, 69-91, 133-155, 185-204, 238-260, 273-295, 332-354, 396-418 and 456-478
316401016614	protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104
316401016615	PS00201 Flavodoxin signature.
316401016616	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
316401016617	Walker A motif; other site
316401016618	PS00017 ATP/GTP-binding site motif A (P-loop).
316401016619	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
316401016620	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
316401016621	GTP binding site; other site
316401016622	Protein of unknown function (DUF1040); Region: DUF1040; pfam06288
316401016623	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
316401016624	serine/threonine protein kinase; Provisional; Region: PRK11768
316401016625	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
316401016626	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
316401016627	catalytic residues [active]
316401016628	hinge region; other site
316401016629	alpha helical domain; other site
316401016630	Signal peptide predicted for ETEC4130 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.948 between residues 19 and 20
316401016631	PS00194 Thioredoxin family active site.
316401016632	hypothetical protein; Provisional; Region: PRK11367
316401016633	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
316401016634	1 probable transmembrane helix predicted for ETEC4131 by TMHMM2.0 at aa 7-26
316401016635	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
316401016636	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
316401016637	putative acyl-acceptor binding pocket; other site
316401016638	1 probable transmembrane helix predicted for ETEC4132 by TMHMM2.0 at aa 21-43
316401016639	Signal peptide predicted for ETEC4132 by SignalP 2.0 HMM (Signal peptide probability 0.854) with cleavage site probability 0.767 between residues 40 and 41
316401016640	DNA polymerase I; Provisional; Region: PRK05755
316401016641	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
316401016642	active site
316401016643	metal binding site 1 [ion binding]; metal-binding site
316401016644	putative 5' ssDNA interaction site; other site
316401016645	metal binding site 3; metal-binding site
316401016646	metal binding site 2 [ion binding]; metal-binding site
316401016647	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
316401016648	putative DNA binding site [nucleotide binding]; other site
316401016649	putative metal binding site [ion binding]; other site
316401016650	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
316401016651	active site
316401016652	catalytic site [active]
316401016653	substrate binding site [chemical binding]; other site
316401016654	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
316401016655	active site
316401016656	DNA binding site [nucleotide binding]
316401016657	catalytic site [active]
316401016658	PS00447 DNA polymerase family A signature.
316401016659	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
316401016660	G1 box; other site
316401016661	GTP/Mg2+ binding site [chemical binding]; other site
316401016662	Switch I region; other site
316401016663	G2 box; other site
316401016664	G3 box; other site
316401016665	Switch II region; other site
316401016666	G4 box; other site
316401016667	G5 box; other site
316401016668	PS00017 ATP/GTP-binding site motif A (P-loop).
316401016669	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078
316401016670	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
316401016671	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316401016672	FeS/SAM binding site; other site
316401016673	HemN C-terminal domain; Region: HemN_C; pfam06969
316401016674	nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923
316401016675	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316401016676	active site
316401016677	phosphorylation site [posttranslational modification]
316401016678	intermolecular recognition site; other site
316401016679	dimerization interface [polypeptide binding]; other site
316401016680	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316401016681	Walker A motif; other site
316401016682	ATP binding site [chemical binding]; other site
316401016683	Walker B motif; other site
316401016684	arginine finger; other site
316401016685	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
316401016686	PS00688 Sigma-54 interaction domain C-terminal part signature.
316401016687	PS00676 Sigma-54 interaction domain ATP-binding region B signature.
316401016688	PS00675 Sigma-54 interaction domain ATP-binding region A signature.
316401016689	nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073
316401016690	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316401016691	putative active site [active]
316401016692	heme pocket [chemical binding]; other site
316401016693	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316401016694	dimer interface [polypeptide binding]; other site
316401016695	phosphorylation site [posttranslational modification]
316401016696	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316401016697	ATP binding site [chemical binding]; other site
316401016698	Mg2+ binding site [ion binding]; other site
316401016699	G-X-G motif; other site
316401016700	glutamine synthetase; Provisional; Region: glnA; PRK09469
316401016701	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
316401016702	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
316401016703	PS00182 Glutamine synthetase class-I adenylation site.
316401016704	PS00181 Glutamine synthetase putative ATP-binding region signature.
316401016705	PS00180 Glutamine synthetase signature 1.
316401016706	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
316401016707	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
316401016708	G1 box; other site
316401016709	putative GEF interaction site [polypeptide binding]; other site
316401016710	GTP/Mg2+ binding site [chemical binding]; other site
316401016711	Switch I region; other site
316401016712	G2 box; other site
316401016713	G3 box; other site
316401016714	Switch II region; other site
316401016715	G4 box; other site
316401016716	G5 box; other site
316401016717	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
316401016718	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
316401016719	PS00017 ATP/GTP-binding site motif A (P-loop).
316401016720	PS00301 GTP-binding elongation factors signature.
316401016721	transcriptional regulator protein; Region: phnR; TIGR03337
316401016722	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
316401016723	DNA-binding site [nucleotide binding]; DNA binding site
316401016724	UTRA domain; Region: UTRA; pfam07702
316401016725	PS00043 Bacterial regulatory proteins, gntR family signature.
316401016726	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
316401016727	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401016728	putative substrate translocation pore; other site
316401016729	phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881
316401016730	Signal peptide predicted for ETEC4143 by SignalP 2.0 HMM (Signal peptide probability 0.749) with cleavage site probability 0.617 between residues 22 and 23
316401016731	12 probable transmembrane helices predicted for ETEC4143 by TMHMM2.0 at aa 7-25, 45-67, 74-91, 96-118, 138-160, 170-189, 221-243, 248-267, 287-309, 314-336, 352-374 and 384-406
316401016732	outer membrane porin L; Provisional; Region: ompL; PRK09980
316401016733	Signal peptide predicted for ETEC4144 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.942 between residues 20 and 21
316401016734	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
316401016735	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401016736	putative substrate translocation pore; other site
316401016737	10 probable transmembrane helices predicted for ETEC4145 by TMHMM2.0 at aa 51-73, 86-108, 118-140, 161-180, 184-206, 271-293, 303-321, 328-350, 379-401 and 414-436
316401016738	PS00872 Sodium:galactoside symporter family signature.
316401016739	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
316401016740	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401016741	11 probable transmembrane helices predicted for ETEC4146 by TMHMM2.0 at aa 47-69, 90-112, 122-144, 157-179, 189-211, 245-267, 277-296, 309-329, 334-356, 388-410 and 420-442
316401016742	PS00872 Sodium:galactoside symporter family signature.
316401016743	alpha-glucosidase; Provisional; Region: PRK10426
316401016744	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
316401016745	YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594
316401016746	putative active site [active]
316401016747	putative catalytic site [active]
316401016748	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
316401016749	9 probable transmembrane helices predicted for ETEC4148 by TMHMM2.0 at aa 20-42, 47-69, 84-106, 113-135, 139-161, 174-196, 200-222, 234-251 and 255-277
316401016750	Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022
316401016751	active site
316401016752	catalytic residues [active]
316401016753	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
316401016754	dimerization interface [polypeptide binding]; other site
316401016755	putative active cleft [active]
316401016756	Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684
316401016757	catalytic residue [active]
316401016758	NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461
316401016759	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
316401016760	PS00895 3-hydroxyisobutyrate dehydrogenase signature.
316401016761	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
316401016762	Ribokinase-like subgroup B.  Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945
316401016763	substrate binding site [chemical binding]; other site
316401016764	ATP binding site [chemical binding]; other site
316401016765	PS00584 pfkB family of carbohydrate kinases signature 2.
316401016766	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
316401016767	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
316401016768	putative DNA binding site [nucleotide binding]; other site
316401016769	putative Zn2+ binding site [ion binding]; other site
316401016770	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
316401016771	PS00894 Bacterial regulatory proteins, deoR family signature.
316401016772	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
316401016773	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
316401016774	motif II; other site
316401016775	hypothetical protein; Reviewed; Region: PRK01637
316401016776	6 probable transmembrane helices predicted for ETEC4156 by TMHMM2.0 at aa 39-61, 101-120, 141-163, 183-205, 212-234 and 244-266
316401016777	PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide.
316401016778	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
316401016779	putative active site [active]
316401016780	dimerization interface [polypeptide binding]; other site
316401016781	putative tRNAtyr binding site [nucleotide binding]; other site
316401016782	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
316401016783	Coenzyme A binding pocket [chemical binding]; other site
316401016784	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500
316401016785	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
316401016786	PS00659 Glycosyl hydrolases family 5 signature.
316401016787	formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564
316401016788	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
316401016789	formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639
316401016790	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
316401016791	4 probable transmembrane helices predicted for ETEC4162 by TMHMM2.0 at aa 21-40, 55-77, 114-136 and 151-173
316401016792	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
316401016793	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
316401016794	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401016795	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
316401016796	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
316401016797	[4Fe-4S] binding site [ion binding]; other site
316401016798	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
316401016799	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
316401016800	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
316401016801	molybdopterin cofactor binding site; other site
316401016802	PS00932 Prokaryotic molybdopterin oxidoreductases signature 3.
316401016803	PS00551 Prokaryotic molybdopterin oxidoreductases signature 1.
316401016804	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
316401016805	Protein of unknown function (DUF3829); Region: DUF3829; pfam12889
316401016806	Signal peptide predicted for ETEC4166 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.989 between residues 21 and 22
316401016807	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401016808	putative frv operon regulatory protein; Provisional; Region: PRK09863
316401016809	HTH domain; Region: HTH_11; pfam08279
316401016810	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
316401016811	active site
316401016812	phosphorylation site [posttranslational modification]
316401016813	putative peptidase; Provisional; Region: PRK09864
316401016814	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
316401016815	oligomer interface [polypeptide binding]; other site
316401016816	active site
316401016817	metal binding site [ion binding]; metal-binding site
316401016818	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
316401016819	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
316401016820	active site
316401016821	P-loop; other site
316401016822	phosphorylation site [posttranslational modification]
316401016823	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
316401016824	9 probable transmembrane helices predicted for ETEC4169 by TMHMM2.0 at aa 139-161, 174-196, 224-246, 259-281, 313-335, 342-364, 379-401, 408-430 and 445-467
316401016825	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
316401016826	active site
316401016827	phosphorylation site [posttranslational modification]
316401016828	PS00372 PTS EIIA domains phosphorylation site signature 2.
316401016829	L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625
316401016830	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
316401016831	intersubunit interface [polypeptide binding]; other site
316401016832	active site
316401016833	Zn2+ binding site [ion binding]; other site
316401016834	L-rhamnose isomerase; Provisional; Region: PRK01076
316401016835	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
316401016836	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
316401016837	N- and C-terminal domain interface [polypeptide binding]; other site
316401016838	active site
316401016839	putative catalytic site [active]
316401016840	metal binding site [ion binding]; metal-binding site
316401016841	ATP binding site [chemical binding]; other site
316401016842	rhamnulokinase; Provisional; Region: rhaB; PRK10640
316401016843	carbohydrate binding site [chemical binding]; other site
316401016844	transcriptional activator RhaS; Provisional; Region: PRK13503
316401016845	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
316401016846	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316401016847	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316401016848	transcriptional activator RhaR; Provisional; Region: PRK13500
316401016849	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
316401016850	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316401016851	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316401016852	PS00041 Bacterial regulatory proteins, araC family signature.
316401016853	L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728
316401016854	RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776
316401016855	10 probable transmembrane helices predicted for ETEC4177 by TMHMM2.0 at aa 4-26, 39-58, 68-90, 97-119, 129-151, 171-188, 208-230, 250-272, 287-306 and 319-338
316401016856	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401016857	superoxide dismutase; Provisional; Region: PRK10925
316401016858	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
316401016859	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
316401016860	PS00088 Manganese and iron superoxide dismutases signature.
316401016861	2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793
316401016862	10 probable transmembrane helices predicted for ETEC4179 by TMHMM2.0 at aa 13-30, 40-62, 75-97, 107-129, 142-164, 168-187, 194-211, 221-243, 255-277 and 287-309
316401016863	6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536
316401016864	MOSC domain; Region: MOSC; pfam03473
316401016865	3-alpha domain; Region: 3-alpha; pfam03475
316401016866	two-component sensor protein; Provisional; Region: cpxA; PRK09470
316401016867	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
316401016868	dimerization interface [polypeptide binding]; other site
316401016869	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316401016870	dimer interface [polypeptide binding]; other site
316401016871	phosphorylation site [posttranslational modification]
316401016872	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316401016873	ATP binding site [chemical binding]; other site
316401016874	Mg2+ binding site [ion binding]; other site
316401016875	G-X-G motif; other site
316401016876	2 probable transmembrane helices predicted for ETEC4181 by TMHMM2.0 at aa 5-27 and 165-187
316401016877	DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955
316401016878	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316401016879	active site
316401016880	intermolecular recognition site; other site
316401016881	dimerization interface [polypeptide binding]; other site
316401016882	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
316401016883	DNA binding site [nucleotide binding]
316401016884	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
316401016885	dimer interface [polypeptide binding]; other site
316401016886	Signal peptide predicted for ETEC4183 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 21 and 22
316401016887	ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509
316401016888	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
316401016889	Signal peptide predicted for ETEC4184 by SignalP 2.0 HMM (Signal peptide probability 0.885) with cleavage site probability 0.502 between residues 30 and 31
316401016890	6 probable transmembrane helices predicted for ETEC4184 by TMHMM2.0 at aa 12-34, 38-60, 80-102, 117-139, 158-175 and 180-199
316401016891	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
316401016892	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
316401016893	active site
316401016894	ADP/pyrophosphate binding site [chemical binding]; other site
316401016895	dimerization interface [polypeptide binding]; other site
316401016896	allosteric effector site; other site
316401016897	fructose-1,6-bisphosphate binding site; other site
316401016898	PS00433 Phosphofructokinase signature.
316401016899	sulfate transporter subunit; Provisional; Region: PRK10752
316401016900	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
316401016901	Signal peptide predicted for ETEC4186 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 19 and 20
316401016902	PS00401 Prokaryotic sulfate-binding proteins signature 1.
316401016903	PS00757 Prokaryotic sulfate-binding proteins signature 2.
316401016904	CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672
316401016905	Signal peptide predicted for ETEC4187 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.503 between residues 18 and 19
316401016906	1 probable transmembrane helix predicted for ETEC4187 by TMHMM2.0 at aa 5-24
316401016907	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
316401016908	triosephosphate isomerase; Provisional; Region: PRK14567
316401016909	substrate binding site [chemical binding]; other site
316401016910	dimer interface [polypeptide binding]; other site
316401016911	catalytic triad [active]
316401016912	PS00171 Triosephosphate isomerase active site.
316401016913	PS00017 ATP/GTP-binding site motif A (P-loop).
316401016914	Protein of unknown function (DUF1454); Region: DUF1454; pfam07305
316401016915	Signal peptide predicted for ETEC4189 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 23 and 24
316401016916	Predicted membrane protein [Function unknown]; Region: COG3152
316401016917	4 probable transmembrane helices predicted for ETEC4190 by TMHMM2.0 at aa 20-37, 41-63, 72-94 and 99-121
316401016918	hypothetical protein; Provisional; Region: PRK09981
316401016919	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
316401016920	Ligand Binding Site [chemical binding]; other site
316401016921	ferredoxin-NADP reductase; Provisional; Region: PRK10926
316401016922	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
316401016923	FAD binding pocket [chemical binding]; other site
316401016924	FAD binding motif [chemical binding]; other site
316401016925	phosphate binding motif [ion binding]; other site
316401016926	beta-alpha-beta structure motif; other site
316401016927	NAD binding pocket [chemical binding]; other site
316401016928	PS00430 TonB-dependent receptor proteins signature 1.
316401016929	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
316401016930	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
316401016931	putative active site [active]
316401016932	glycerol kinase; Provisional; Region: glpK; PRK00047
316401016933	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
316401016934	N- and C-terminal domain interface [polypeptide binding]; other site
316401016935	active site
316401016936	MgATP binding site [chemical binding]; other site
316401016937	catalytic site [active]
316401016938	metal binding site [ion binding]; metal-binding site
316401016939	glycerol binding site [chemical binding]; other site
316401016940	homotetramer interface [polypeptide binding]; other site
316401016941	homodimer interface [polypeptide binding]; other site
316401016942	FBP binding site [chemical binding]; other site
316401016943	protein IIAGlc interface [polypeptide binding]; other site
316401016944	PS00445 FGGY family of carbohydrate kinases signature 2.
316401016945	PS00933 FGGY family of carbohydrate kinases signature 1.
316401016946	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
316401016947	amphipathic channel; other site
316401016948	Asn-Pro-Ala signature motifs; other site
316401016949	6 probable transmembrane helices predicted for ETEC4196 by TMHMM2.0 at aa 12-34, 44-66, 87-109, 143-165, 178-200 and 229-251
316401016950	PS00221 MIP family signature.
316401016951	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401016952	septal ring assembly protein ZapB; Provisional; Region: PRK15422
316401016953	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
316401016954	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751
316401016955	UbiA prenyltransferase family; Region: UbiA; pfam01040
316401016956	9 probable transmembrane helices predicted for ETEC4199 by TMHMM2.0 at aa 21-40, 44-63, 98-117, 121-143, 150-172, 177-199, 228-247, 251-270 and 290-307
316401016957	Signal peptide predicted for ETEC4199 by SignalP 2.0 HMM (Signal peptide probability 0.945) with cleavage site probability 0.945 between residues 35 and 36
316401016958	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
316401016959	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316401016960	Walker A motif; other site
316401016961	ATP binding site [chemical binding]; other site
316401016962	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
316401016963	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
316401016964	PS00017 ATP/GTP-binding site motif A (P-loop).
316401016965	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
316401016966	active site
316401016967	HslU subunit interaction site [polypeptide binding]; other site
316401016968	essential cell division protein FtsN; Provisional; Region: PRK10927
316401016969	cell division protein FtsN; Provisional; Region: PRK12757
316401016970	1 probable transmembrane helix predicted for ETEC4202 by TMHMM2.0 at aa 29-51
316401016971	Signal peptide predicted for ETEC4202 by SignalP 2.0 HMM (Signal peptide probability 0.873) with cleavage site probability 0.366 between residues 42 and 43
316401016972	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
316401016973	DNA binding site [nucleotide binding]
316401016974	DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041
316401016975	domain linker motif; other site
316401016976	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
316401016977	dimerization interface [polypeptide binding]; other site
316401016978	ligand binding site [chemical binding]; other site
316401016979	PS00356 Bacterial regulatory proteins, lacI family signature.
316401016980	primosome assembly protein PriA; Validated; Region: PRK05580
316401016981	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
316401016982	ATP binding site [chemical binding]; other site
316401016983	putative Mg++ binding site [ion binding]; other site
316401016984	helicase superfamily c-terminal domain; Region: HELICc; smart00490
316401016985	ATP-binding site [chemical binding]; other site
316401016986	PS00017 ATP/GTP-binding site motif A (P-loop).
316401016987	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
316401016988	PS00190 Cytochrome c family heme-binding site signature.
316401016989	PS01143 Ribosomal protein L31 signature.
316401016990	hypothetical protein; Provisional; Region: PRK10030
316401016991	Signal peptide predicted for ETEC4206 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 18 and 19
316401016992	Met Repressor, MetJ.  MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490
316401016993	dimerization interface [polypeptide binding]; other site
316401016994	DNA binding site [nucleotide binding]
316401016995	corepressor binding sites; other site
316401016996	cystathionine gamma-synthase; Provisional; Region: PRK08045
316401016997	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
316401016998	homodimer interface [polypeptide binding]; other site
316401016999	substrate-cofactor binding pocket; other site
316401017000	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316401017001	catalytic residue [active]
316401017002	PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site.
316401017003	bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466
316401017004	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
316401017005	putative catalytic residues [active]
316401017006	putative nucleotide binding site [chemical binding]; other site
316401017007	putative aspartate binding site [chemical binding]; other site
316401017008	ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892
316401017009	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
316401017010	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
316401017011	PS00324 Aspartokinase signature.
316401017012	PS01042 Homoserine dehydrogenase signature.
316401017013	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
316401017014	FAD binding site [chemical binding]; other site
316401017015	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
316401017016	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
316401017017	heme binding site [chemical binding]; other site
316401017018	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
316401017019	PS00436 Peroxidases active site signature.
316401017020	PS00435 Peroxidases proximal heme-ligand signature.
316401017021	PS00017 ATP/GTP-binding site motif A (P-loop).
316401017022	EamA-like transporter family; Region: EamA; pfam00892
316401017023	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
316401017024	EamA-like transporter family; Region: EamA; pfam00892
316401017025	10 probable transmembrane helices predicted for ETEC4212 by TMHMM2.0 at aa 7-29, 39-61, 73-92, 96-118, 125-144, 154-176, 183-205, 215-237, 244-266 and 270-289
316401017026	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738
316401017027	Signal peptide predicted for ETEC4213 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.635 between residues 20 and 21
316401017028	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
316401017029	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
316401017030	dimer interface [polypeptide binding]; other site
316401017031	active site
316401017032	metal binding site [ion binding]; metal-binding site
316401017033	PS00060 Iron-containing alcohol dehydrogenases signature 2.
316401017034	PS00687 Aldehyde dehydrogenases glutamic acid active site.
316401017035	PS00913 Iron-containing alcohol dehydrogenases signature 1.
316401017036	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
316401017037	active site
316401017038	intersubunit interactions; other site
316401017039	catalytic residue [active]
316401017040	PS00958 Transaldolase active site.
316401017041	PS01054 Transaldolase signature 1.
316401017042	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
316401017043	dimerization domain swap beta strand [polypeptide binding]; other site
316401017044	regulatory protein interface [polypeptide binding]; other site
316401017045	active site
316401017046	regulatory phosphorylation site [posttranslational modification]; other site
316401017047	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
316401017048	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
316401017049	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
316401017050	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
316401017051	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
316401017052	active site
316401017053	phosphorylation site [posttranslational modification]
316401017054	PS00742 PEP-utilizing enzymes signature 2.
316401017055	PS00370 PEP-utilizing enzymes phosphorylation site signature.
316401017056	PS00369 PTS HPR component histidine phosphorylation site signature.
316401017057	putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478
316401017058	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
316401017059	8 probable transmembrane helices predicted for ETEC4217 by TMHMM2.0 at aa 21-40, 60-82, 95-117, 132-154, 175-194, 214-236, 283-305 and 315-334
316401017060	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
316401017061	active site
316401017062	P-loop; other site
316401017063	phosphorylation site [posttranslational modification]
316401017064	Signal peptide predicted for ETEC4218 by SignalP 2.0 HMM (Signal peptide probability 0.962) with cleavage site probability 0.795 between residues 20 and 21
316401017065	putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983
316401017066	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
316401017067	dimer interface [polypeptide binding]; other site
316401017068	active site
316401017069	glycine loop; other site
316401017070	PS00850 Glycine radical signature.
316401017071	pyruvate formate lyase II activase; Provisional; Region: PRK10076
316401017072	PS01087 Radical activating enzymes signature.
316401017073	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
316401017074	active site
316401017075	P-loop; other site
316401017076	phosphorylation site [posttranslational modification]
316401017077	Signal peptide predicted for ETEC4221 by SignalP 2.0 HMM (Signal peptide probability 0.825) with cleavage site probability 0.779 between residues 20 and 21
316401017078	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
316401017079	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316401017080	PS00041 Bacterial regulatory proteins, araC family signature.
316401017081	hypothetical protein; Provisional; Region: PRK10649
316401017082	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
316401017083	Sulfatase; Region: Sulfatase; pfam00884
316401017084	5 probable transmembrane helices predicted for ETEC4223 by TMHMM2.0 at aa 13-35, 45-63, 70-92, 118-140 and 153-170
316401017085	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
316401017086	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
316401017087	PS00393 Phosphoenolpyruvate carboxylase active site 2.
316401017088	PS00781 Phosphoenolpyruvate carboxylase active site 1.
316401017089	acetylornithine deacetylase; Provisional; Region: PRK05111
316401017090	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
316401017091	metal binding site [ion binding]; metal-binding site
316401017092	putative dimer interface [polypeptide binding]; other site
316401017093	PS00759 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2.
316401017094	PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1.
316401017095	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
316401017096	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
316401017097	PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.
316401017098	PS01224 N-acetyl-gamma-glutamyl-phosphate reductase active site.
316401017099	AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249
316401017100	nucleotide binding site [chemical binding]; other site
316401017101	N-acetyl-L-glutamate binding site [chemical binding]; other site
316401017102	argininosuccinate lyase; Provisional; Region: PRK04833
316401017103	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
316401017104	active sites [active]
316401017105	tetramer interface [polypeptide binding]; other site
316401017106	PS00163 Fumarate lyases signature.
316401017107	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
316401017108	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401017109	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
316401017110	dimerization interface [polypeptide binding]; other site
316401017111	PS00044 Bacterial regulatory proteins, lysR family signature.
316401017112	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
316401017113	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
316401017114	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
316401017115	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
316401017116	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
316401017117	hypothetical protein; Provisional; Region: PRK11056
316401017118	Signal peptide predicted for ETEC4232 by SignalP 2.0 HMM (Signal peptide probability 0.991) with cleavage site probability 0.981 between residues 26 and 27
316401017119	4 probable transmembrane helices predicted for ETEC4232 by TMHMM2.0 at aa 9-28, 32-50, 62-84 and 89-108
316401017120	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
316401017121	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316401017122	S-adenosylmethionine binding site [chemical binding]; other site
316401017123	PS01231 RNA methyltransferase trmA family signature 2.
316401017124	PS01230 RNA methyltransferase trmA family signature 1.
316401017125	vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641
316401017126	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
316401017127	N-terminal plug; other site
316401017128	ligand-binding site [chemical binding]; other site
316401017129	PS00430 TonB-dependent receptor proteins signature 1.
316401017130	Signal peptide predicted for ETEC4234 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 20 and 21
316401017131	PS01156 TonB-dependent receptor proteins signature 2.
316401017132	glutamate racemase; Provisional; Region: PRK00865
316401017133	PS00923 Aspartate and glutamate racemases signature 1.
316401017134	PS00924 Aspartate and glutamate racemases signature 2.
316401017135	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
316401017136	FAD binding domain; Region: FAD_binding_4; pfam01565
316401017137	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
316401017138	Biotin operon repressor [Transcription]; Region: BirA; COG1654
316401017139	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
316401017140	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
316401017141	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
316401017142	pantothenate kinase; Provisional; Region: PRK05439
316401017143	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
316401017144	ATP-binding site [chemical binding]; other site
316401017145	CoA-binding site [chemical binding]; other site
316401017146	Mg2+-binding site [ion binding]; other site
316401017147	PS00017 ATP/GTP-binding site motif A (P-loop).
316401017148	elongation factor Tu; Reviewed; Region: PRK00049
316401017149	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
316401017150	G1 box; other site
316401017151	GEF interaction site [polypeptide binding]; other site
316401017152	GTP/Mg2+ binding site [chemical binding]; other site
316401017153	Switch I region; other site
316401017154	G2 box; other site
316401017155	G3 box; other site
316401017156	Switch II region; other site
316401017157	G4 box; other site
316401017158	G5 box; other site
316401017159	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
316401017160	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
316401017161	Antibiotic Binding Site [chemical binding]; other site
316401017162	PS00017 ATP/GTP-binding site motif A (P-loop).
316401017163	PS00301 GTP-binding elongation factors signature.
316401017164	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
316401017165	3 probable transmembrane helices predicted for ETEC4240 by TMHMM2.0 at aa 19-36, 40-62 and 94-116
316401017166	PS01067 Protein secE/sec61-gamma signature.
316401017167	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
316401017168	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
316401017169	putative homodimer interface [polypeptide binding]; other site
316401017170	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
316401017171	heterodimer interface [polypeptide binding]; other site
316401017172	homodimer interface [polypeptide binding]; other site
316401017173	PS01014 Transcription termination factor nusG signature.
316401017174	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
316401017175	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
316401017176	23S rRNA interface [nucleotide binding]; other site
316401017177	L7/L12 interface [polypeptide binding]; other site
316401017178	putative thiostrepton binding site; other site
316401017179	L25 interface [polypeptide binding]; other site
316401017180	PS00359 Ribosomal protein L11 signature.
316401017181	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
316401017182	mRNA/rRNA interface [nucleotide binding]; other site
316401017183	PS01199 Ribosomal protein L1 signature.
316401017184	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
316401017185	23S rRNA interface [nucleotide binding]; other site
316401017186	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
316401017187	PS01109 Ribosomal protein L10 signature.
316401017188	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
316401017189	core dimer interface [polypeptide binding]; other site
316401017190	peripheral dimer interface [polypeptide binding]; other site
316401017191	L10 interface [polypeptide binding]; other site
316401017192	L11 interface [polypeptide binding]; other site
316401017193	putative EF-Tu interaction site [polypeptide binding]; other site
316401017194	putative EF-G interaction site [polypeptide binding]; other site
316401017195	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
316401017196	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
316401017197	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
316401017198	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
316401017199	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
316401017200	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
316401017201	RPB3 interaction site [polypeptide binding]; other site
316401017202	RPB1 interaction site [polypeptide binding]; other site
316401017203	RPB11 interaction site [polypeptide binding]; other site
316401017204	RPB10 interaction site [polypeptide binding]; other site
316401017205	PS01166 RNA polymerases beta chain signature.
316401017206	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
316401017207	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
316401017208	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
316401017209	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
316401017210	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
316401017211	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
316401017212	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
316401017213	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
316401017214	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
316401017215	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
316401017216	DNA binding site [nucleotide binding]
316401017217	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
316401017218	stationary phase growth adaptation protein; Provisional; Region: PRK09717
316401017219	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
316401017220	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316401017221	FeS/SAM binding site; other site
316401017222	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
316401017223	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
316401017224	ThiS interaction site; other site
316401017225	putative active site [active]
316401017226	tetramer interface [polypeptide binding]; other site
316401017227	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
316401017228	thiS-thiF/thiG interaction site; other site
316401017229	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
316401017230	thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356
316401017231	ATP binding site [chemical binding]; other site
316401017232	substrate interface [chemical binding]; other site
316401017233	1 probable transmembrane helix predicted for ETEC4252 by TMHMM2.0 at aa 31-53
316401017234	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
316401017235	thiamine phosphate binding site [chemical binding]; other site
316401017236	active site
316401017237	pyrophosphate binding site [ion binding]; other site
316401017238	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
316401017239	ThiC-associated domain; Region: ThiC-associated; pfam13667
316401017240	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
316401017241	Regulator of sigma D [Transcription]; Region: Rsd; COG3160
316401017242	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
316401017243	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
316401017244	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
316401017245	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
316401017246	putative NADH binding site [chemical binding]; other site
316401017247	putative active site [active]
316401017248	nudix motif; other site
316401017249	putative metal binding site [ion binding]; other site
316401017250	PS00893 mutT domain signature.
316401017251	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
316401017252	substrate binding site [chemical binding]; other site
316401017253	active site
316401017254	PS00906 Uroporphyrinogen decarboxylase signature 1.
316401017255	PS00907 Uroporphyrinogen decarboxylase signature 2.
316401017256	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
316401017257	Active_site [active]
316401017258	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068
316401017259	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
316401017260	IHF dimer interface [polypeptide binding]; other site
316401017261	IHF - DNA interface [nucleotide binding]; other site
316401017262	PS00045 Bacterial histone-like DNA-binding proteins signature.
316401017263	Protein of unknown function (DUF1481); Region: DUF1481; pfam07356
316401017264	Signal peptide predicted for ETEC4261 by SignalP 2.0 HMM (Signal peptide probability 0.880) with cleavage site probability 0.507 between residues 46 and 47
316401017265	zinc resistance protein; Provisional; Region: zraP; PRK11546
316401017266	dimer interface [polypeptide binding]; other site
316401017267	1 probable transmembrane helix predicted for ETEC4262 by TMHMM2.0 at aa 7-29
316401017268	Signal peptide predicted for ETEC4262 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 26 and 27
316401017269	sensor protein ZraS; Provisional; Region: PRK10364
316401017270	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316401017271	dimer interface [polypeptide binding]; other site
316401017272	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316401017273	ATP binding site [chemical binding]; other site
316401017274	Mg2+ binding site [ion binding]; other site
316401017275	G-X-G motif; other site
316401017276	transcriptional regulatory protein ZraR; Provisional; Region: PRK10365
316401017277	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316401017278	active site
316401017279	phosphorylation site [posttranslational modification]
316401017280	intermolecular recognition site; other site
316401017281	dimerization interface [polypeptide binding]; other site
316401017282	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316401017283	Walker A motif; other site
316401017284	ATP binding site [chemical binding]; other site
316401017285	Walker B motif; other site
316401017286	arginine finger; other site
316401017287	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
316401017288	PS00675 Sigma-54 interaction domain ATP-binding region A signature.
316401017289	PS00676 Sigma-54 interaction domain ATP-binding region B signature.
316401017290	PS00688 Sigma-54 interaction domain C-terminal part signature.
316401017291	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
316401017292	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
316401017293	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
316401017294	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
316401017295	PS00184 Phosphoribosylglycinamide synthetase signature.
316401017296	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
316401017297	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
316401017298	purine monophosphate binding site [chemical binding]; other site
316401017299	dimer interface [polypeptide binding]; other site
316401017300	putative catalytic residues [active]
316401017301	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
316401017302	hypothetical protein; Provisional; Region: PRK10039
316401017303	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
316401017304	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
316401017305	Coenzyme A binding pocket [chemical binding]; other site
316401017306	homoserine O-succinyltransferase; Provisional; Region: PRK05368
316401017307	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
316401017308	proposed active site lysine [active]
316401017309	conserved cys residue [active]
316401017310	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
316401017311	malate synthase A; Region: malate_syn_A; TIGR01344
316401017312	active site
316401017313	PS00510 Malate synthase signature.
316401017314	isocitrate lyase; Provisional; Region: PRK15063
316401017315	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
316401017316	tetramer interface [polypeptide binding]; other site
316401017317	active site
316401017318	Mg2+/Mn2+ binding site [ion binding]; other site
316401017319	PS00161 Isocitrate lyase signature.
316401017320	PS00030 Eukaryotic putative RNA-binding region RNP-1 signature.
316401017321	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
316401017322	bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946
316401017323	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
316401017324	ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906
316401017325	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
316401017326	transcriptional repressor IclR; Provisional; Region: PRK11569
316401017327	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
316401017328	Bacterial transcriptional regulator; Region: IclR; pfam01614
316401017329	PS01051 Bacterial regulatory proteins, iclR family signature.
316401017330	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
316401017331	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
316401017332	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
316401017333	substrate binding pocket [chemical binding]; other site
316401017334	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
316401017335	B12 binding site [chemical binding]; other site
316401017336	cobalt ligand [ion binding]; other site
316401017337	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
316401017338	PS00017 ATP/GTP-binding site motif A (P-loop).
316401017339	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
316401017340	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
316401017341	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
316401017342	8 probable transmembrane helices predicted for ETEC4275 by TMHMM2.0 at aa 4-26, 67-89, 99-121, 133-155, 175-194, 201-223, 238-260 and 272-294
316401017343	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
316401017344	active site pocket [active]
316401017345	oxyanion hole [active]
316401017346	catalytic triad [active]
316401017347	active site nucleophile [active]
316401017348	23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475
316401017349	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
316401017350	RNA binding surface [nucleotide binding]; other site
316401017351	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
316401017352	probable active site [active]
316401017353	PS01149 Rsu family of pseudouridine synthase signature.
316401017354	hypothetical protein; Provisional; Region: PRK10515
316401017355	aspartate kinase III; Validated; Region: PRK09084
316401017356	AAK_AKiii-LysC-EC: Amino Acid Kinase Superfamily (AAK), AKiii-LysC-EC: this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKIII. AKIII is a monofunctional class enzyme (LysC) found in some...; Region: AAK_AKiii-LysC-EC; cd04258
316401017357	nucleotide binding site [chemical binding]; other site
316401017358	putative catalytic residues [active]
316401017359	aspartate binding site [chemical binding]; other site
316401017360	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
316401017361	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917
316401017362	dimer interface [polypeptide binding]; other site
316401017363	PS00324 Aspartokinase signature.
316401017364	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
316401017365	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
316401017366	active site
316401017367	dimer interface [polypeptide binding]; other site
316401017368	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
316401017369	dimer interface [polypeptide binding]; other site
316401017370	active site
316401017371	PS00765 Phosphoglucose isomerase signature 1.
316401017372	PS00174 Phosphoglucose isomerase signature 2.
316401017373	Signal peptide predicted for ETEC4281 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 21 and 22
316401017374	Protein of unknown function (DUF2886); Region: DUF2886; pfam11102
316401017375	Signal peptide predicted for ETEC4282 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.823 between residues 20 and 21
316401017376	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401017377	Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251
316401017378	Signal peptide predicted for ETEC4283 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 20 and 21
316401017379	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
316401017380	Signal peptide predicted for ETEC4284 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 20 and 21
316401017381	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401017382	phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833
316401017383	4 probable transmembrane helices predicted for ETEC4285 by TMHMM2.0 at aa 13-35, 55-77, 84-103 and 113-130
316401017384	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
316401017385	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401017386	putative substrate translocation pore; other site
316401017387	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401017388	12 probable transmembrane helices predicted for ETEC4286 by TMHMM2.0 at aa 13-35, 55-77, 90-109, 129-151, 164-186, 201-220, 271-293, 313-333, 346-368, 373-395, 408-427 and 442-464
316401017389	PS00216 Sugar transport proteins signature 1.
316401017390	PS00217 Sugar transport proteins signature 2.
316401017391	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401017392	Signal peptide predicted for ETEC4286 by SignalP 2.0 HMM (Signal peptide probability 0.702) with cleavage site probability 0.525 between residues 25 and 26
316401017393	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
316401017394	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401017395	dimer interface [polypeptide binding]; other site
316401017396	conserved gate region; other site
316401017397	putative PBP binding loops; other site
316401017398	ABC-ATPase subunit interface; other site
316401017399	6 probable transmembrane helices predicted for ETEC4287 by TMHMM2.0 at aa 13-35, 89-111, 124-143, 153-175, 205-227 and 258-280
316401017400	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
316401017401	Signal peptide predicted for ETEC4287 by SignalP 2.0 HMM (Signal peptide probability 0.934) with cleavage site probability 0.683 between residues 36 and 37
316401017402	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316401017403	dimer interface [polypeptide binding]; other site
316401017404	conserved gate region; other site
316401017405	putative PBP binding loops; other site
316401017406	ABC-ATPase subunit interface; other site
316401017407	8 probable transmembrane helices predicted for ETEC4288 by TMHMM2.0 at aa 17-36, 40-57, 70-92, 284-306, 319-341, 370-392, 413-435 and 484-506
316401017408	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
316401017409	maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474
316401017410	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
316401017411	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
316401017412	Signal peptide predicted for ETEC4289 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.974 between residues 26 and 27
316401017413	maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000
316401017414	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
316401017415	Walker A/P-loop; other site
316401017416	ATP binding site [chemical binding]; other site
316401017417	Q-loop/lid; other site
316401017418	ABC transporter signature motif; other site
316401017419	Walker B; other site
316401017420	D-loop; other site
316401017421	H-loop/switch region; other site
316401017422	TOBE domain; Region: TOBE_2; pfam08402
316401017423	PS00017 ATP/GTP-binding site motif A (P-loop).
316401017424	PS00211 ABC transporters family signature.
316401017425	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
316401017426	trimer interface; other site
316401017427	sugar binding site [chemical binding]; other site
316401017428	Signal peptide predicted for ETEC4291 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.972 between residues 25 and 26
316401017429	maltose regulon periplasmic protein; Provisional; Region: PRK10564
316401017430	Signal peptide predicted for ETEC4292 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.995 between residues 26 and 27
316401017431	hypothetical protein; Validated; Region: PRK09718
316401017432	SopA-like central domain; Region: SopA; pfam13981
316401017433	chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655
316401017434	PS00017 ATP/GTP-binding site motif A (P-loop).
316401017435	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
316401017436	UbiA prenyltransferase family; Region: UbiA; pfam01040
316401017437	7 probable transmembrane helices predicted for ETEC4295 by TMHMM2.0 at aa 23-40, 45-67, 99-132, 160-182, 213-230, 235-252 and 272-289
316401017438	PS00943 UbiA prenyltransferase family signature.
316401017439	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
316401017440	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
316401017441	putative acyl-acceptor binding pocket; other site
316401017442	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
316401017443	2 probable transmembrane helices predicted for ETEC4297 by TMHMM2.0 at aa 57-79 and 99-121
316401017444	PS01069 Prokaryotic diacylglycerol kinase signature.
316401017445	LexA repressor; Validated; Region: PRK00215
316401017446	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
316401017447	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
316401017448	Catalytic site [active]
316401017449	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
316401017450	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
316401017451	13 probable transmembrane helices predicted for ETEC4299 by TMHMM2.0 at aa 5-22, 29-51, 61-83, 107-129, 149-171, 178-200, 205-227, 259-281, 285-307, 339-361, 371-393, 406-423 and 427-446
316401017452	hypothetical protein; Provisional; Region: PRK10428
316401017453	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
316401017454	metal binding site 2 [ion binding]; metal-binding site
316401017455	putative DNA binding helix; other site
316401017456	metal binding site 1 [ion binding]; metal-binding site
316401017457	dimer interface [polypeptide binding]; other site
316401017458	structural Zn2+ binding site [ion binding]; other site
316401017459	Protein of unknown function (DUF2713); Region: DUF2713; pfam10897
316401017460	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
316401017461	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
316401017462	Competence protein CoiA-like family; Region: CoiA; cl11541
316401017463	Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112
316401017464	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
316401017465	active site
316401017466	catalytic site [active]
316401017467	substrate binding site [chemical binding]; other site
316401017468	Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896
316401017469	Uncharacterized conserved protein [Function unknown]; Region: COG5532
316401017470	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
316401017471	non-specific DNA binding site [nucleotide binding]; other site
316401017472	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
316401017473	salt bridge; other site
316401017474	sequence-specific DNA binding site [nucleotide binding]; other site
316401017475	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
316401017476	Catalytic site [active]
316401017477	DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744
316401017478	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
316401017479	DNA-binding site [nucleotide binding]; DNA binding site
316401017480	PerC transcriptional activator; Region: PerC; pfam06069
316401017481	DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869
316401017482	PS00092 N-6 Adenine-specific DNA methylases signature.
316401017483	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
316401017484	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
316401017485	KilA-N domain; Region: KilA-N; pfam04383
316401017486	Protein of unknown function (DUF968); Region: DUF968; pfam06147
316401017487	Antitermination protein; Region: Antiterm; pfam03589
316401017488	DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684
316401017489	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
316401017490	Zn binding sites [ion binding]; other site
316401017491	Antitermination protein; Region: Antiterm; pfam03589
316401017492	PS00190 Cytochrome c family heme-binding site signature.
316401017493	1 probable transmembrane helix predicted for ETEC4327 by TMHMM2.0 at aa 7-24
316401017494	3 probable transmembrane helices predicted for ETEC4328 by TMHMM2.0 at aa 20-42, 55-74 and 89-106
316401017495	Protein of unknown function (DUF754); Region: DUF754; pfam05449
316401017496	3 probable transmembrane helices predicted for ETEC4329 by TMHMM2.0 at aa 7-26, 39-61 and 66-85
316401017497	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401017498	Predicted chitinase [General function prediction only]; Region: COG3179
316401017499	catalytic residue [active]
316401017500	Signal peptide predicted for ETEC4331 by SignalP 2.0 HMM (Signal peptide probability 0.977) with cleavage site probability 0.953 between residues 23 and 24
316401017501	1 probable transmembrane helix predicted for ETEC4331 by TMHMM2.0 at aa 5-27
316401017502	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401017503	negative regulator GrlR; Provisional; Region: PRK14051
316401017504	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
316401017505	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
316401017506	active site
316401017507	Phage terminase, small subunit; Region: Terminase_4; pfam05119
316401017508	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
316401017509	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401017510	Phage-related protein [Function unknown]; Region: COG4695
316401017511	Phage portal protein; Region: Phage_portal; pfam04860
316401017512	Phage head maturation protease [General function prediction only]; Region: COG3740
316401017513	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
316401017514	Phage capsid family; Region: Phage_capsid; pfam05065
316401017515	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
316401017516	oligomerization interface [polypeptide binding]; other site
316401017517	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
316401017518	Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386
316401017519	Phage tail sheath protein; Region: Phage_sheath_1; pfam04984
316401017520	Phage tail tube protein; Region: Tail_tube; pfam10618
316401017521	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
316401017522	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
316401017523	1 probable transmembrane helix predicted for ETEC4346 by TMHMM2.0 at aa 35-57
316401017524	Signal peptide predicted for ETEC4347 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 19 and 20
316401017525	Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228
316401017526	DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157
316401017527	Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379
316401017528	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
316401017529	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
316401017530	Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; pfam06890
316401017531	Phage protein GP46; Region: GP46; pfam07409
316401017532	Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299
316401017533	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3778
316401017534	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
316401017535	multiple promoter invertase; Provisional; Region: mpi; PRK13413
316401017536	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
316401017537	catalytic residues [active]
316401017538	catalytic nucleophile [active]
316401017539	Presynaptic Site I dimer interface [polypeptide binding]; other site
316401017540	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
316401017541	Synaptic Flat tetramer interface [polypeptide binding]; other site
316401017542	Synaptic Site I dimer interface [polypeptide binding]; other site
316401017543	DNA binding site [nucleotide binding]
316401017544	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
316401017545	DNA-binding interface [nucleotide binding]; DNA binding site
316401017546	PS00397 Site-specific recombinases active site.
316401017547	PS00398 Site-specific recombinases signature 2.
316401017548	PS00017 ATP/GTP-binding site motif A (P-loop).
316401017549	DinI-like family; Region: DinI; pfam06183
316401017550	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
316401017551	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
316401017552	active site
316401017553	DNA binding site [nucleotide binding]
316401017554	Int/Topo IB signature motif; other site
316401017555	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
316401017556	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
316401017557	FMN binding site [chemical binding]; other site
316401017558	active site
316401017559	catalytic residues [active]
316401017560	substrate binding site [chemical binding]; other site
316401017561	PS01136 Uncharacterized protein family UPF0034 signature.
316401017562	phage shock protein G; Reviewed; Region: pspG; PRK09459
316401017563	Signal peptide predicted for ETEC4360 by SignalP 2.0 HMM (Signal peptide probability 0.712) with cleavage site probability 0.433 between residues 31 and 32
316401017564	2 probable transmembrane helices predicted for ETEC4360 by TMHMM2.0 at aa 7-29 and 39-61
316401017565	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
316401017566	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
316401017567	NADP binding site [chemical binding]; other site
316401017568	dimer interface [polypeptide binding]; other site
316401017569	PS01162 Quinone oxidoreductase / zeta-crystallin signature.
316401017570	replicative DNA helicase; Provisional; Region: PRK08006
316401017571	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
316401017572	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
316401017573	Walker A motif; other site
316401017574	ATP binding site [chemical binding]; other site
316401017575	Walker B motif; other site
316401017576	DNA binding loops [nucleotide binding]
316401017577	PS00017 ATP/GTP-binding site motif A (P-loop).
316401017578	alanine racemase; Reviewed; Region: alr; PRK00053
316401017579	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
316401017580	active site
316401017581	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
316401017582	substrate binding site [chemical binding]; other site
316401017583	catalytic residues [active]
316401017584	dimer interface [polypeptide binding]; other site
316401017585	PS00395 Alanine racemase pyridoxal-phosphate attachment site.
316401017586	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
316401017587	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
316401017588	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316401017589	homodimer interface [polypeptide binding]; other site
316401017590	catalytic residue [active]
316401017591	PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site.
316401017592	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
316401017593	motif II; other site
316401017594	Signal peptide predicted for ETEC4365 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.874 between residues 25 and 26
316401017595	secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ
316401017596	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
316401017597	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
316401017598	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
316401017599	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
316401017600	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
316401017601	PS00211 ABC transporters family signature.
316401017602	PS00017 ATP/GTP-binding site motif A (P-loop).
316401017603	PS00211 ABC transporters family signature.
316401017604	PS00017 ATP/GTP-binding site motif A (P-loop).
316401017605	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
316401017606	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
316401017607	dimer interface [polypeptide binding]; other site
316401017608	ssDNA binding site [nucleotide binding]; other site
316401017609	tetramer (dimer of dimers) interface [polypeptide binding]; other site
316401017610	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
316401017611	PS00735 Single-strand binding protein family signature 1.
316401017612	PS00736 Single-strand binding protein family signature 2.
316401017613	2 probable transmembrane helices predicted for ETEC4370 by TMHMM2.0 at aa 10-29 and 36-58
316401017614	potential frameshift: common BLAST hit: gi|383181375|ref|YP_005459380.1| signal transduction protein
316401017615	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
316401017616	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
316401017617	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
316401017618	Signal peptide predicted for ETEC4371 by SignalP 2.0 HMM (Signal peptide probability 0.869) with cleavage site probability 0.861 between residues 34 and 35
316401017619	2 probable transmembrane helices predicted for ETEC4371 by TMHMM2.0 at aa 10-32 and 239-261
316401017620	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
316401017621	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
316401017622	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316401017623	PS00041 Bacterial regulatory proteins, araC family signature.
316401017624	redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002
316401017625	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
316401017626	DNA binding residues [nucleotide binding]
316401017627	dimer interface [polypeptide binding]; other site
316401017628	[2Fe-2S] cluster binding site [ion binding]; other site
316401017629	PS00552 Bacterial regulatory proteins, merR family signature.
316401017630	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
316401017631	13 probable transmembrane helices predicted for ETEC4374 by TMHMM2.0 at aa 29-51, 56-78, 85-107, 112-134, 146-165, 175-197, 202-224, 244-266, 307-329, 334-351, 356-378, 393-415 and 428-447
316401017632	PS00017 ATP/GTP-binding site motif A (P-loop).
316401017633	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
316401017634	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
316401017635	11 probable transmembrane helices predicted for ETEC4375 by TMHMM2.0 at aa 4-21, 28-50, 85-107, 114-136, 159-181, 188-205, 233-255, 276-298, 313-335, 361-383 and 398-420
316401017636	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
316401017637	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
316401017638	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
316401017639	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
316401017640	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
316401017641	Na binding site [ion binding]; other site
316401017642	13 probable transmembrane helices predicted for ETEC4377 by TMHMM2.0 at aa 33-55, 76-98, 103-125, 146-168, 183-205, 212-234, 261-283, 303-325, 359-381, 402-424, 428-450, 462-484 and 494-516
316401017643	PS00457 Sodium:solute symporter family signature 2.
316401017644	PS00456 Sodium:solute symporter family signature 1.
316401017645	Signal peptide predicted for ETEC4377 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 18 and 19
316401017646	Predicted membrane protein [Function unknown]; Region: COG3162
316401017647	2 probable transmembrane helices predicted for ETEC4378 by TMHMM2.0 at aa 25-47 and 62-84
316401017648	acetyl-CoA synthetase; Provisional; Region: PRK00174
316401017649	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
316401017650	active site
316401017651	CoA binding site [chemical binding]; other site
316401017652	acyl-activating enzyme (AAE) consensus motif; other site
316401017653	AMP binding site [chemical binding]; other site
316401017654	acetate binding site [chemical binding]; other site
316401017655	PS00455 Putative AMP-binding domain signature.
316401017656	PS00018 EF-hand calcium-binding domain.
316401017657	cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125
316401017658	Signal peptide predicted for ETEC4380 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 26 and 27
316401017659	PS00190 Cytochrome c family heme-binding site signature.
316401017660	PS00190 Cytochrome c family heme-binding site signature.
316401017661	PS00190 Cytochrome c family heme-binding site signature.
316401017662	PS00190 Cytochrome c family heme-binding site signature.
316401017663	cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659
316401017664	Signal peptide predicted for ETEC4381 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.882 between residues 32 and 33
316401017665	PS00190 Cytochrome c family heme-binding site signature.
316401017666	PS00190 Cytochrome c family heme-binding site signature.
316401017667	PS00190 Cytochrome c family heme-binding site signature.
316401017668	PS00190 Cytochrome c family heme-binding site signature.
316401017669	PS00190 Cytochrome c family heme-binding site signature.
316401017670	cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149
316401017671	Signal peptide predicted for ETEC4382 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.995 between residues 27 and 28
316401017672	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401017673	Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301
316401017674	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
316401017675	8 probable transmembrane helices predicted for ETEC4383 by TMHMM2.0 at aa 15-37, 57-76, 91-113, 151-170, 180-202, 222-241, 256-278 and 290-312
316401017676	heme lyase subunit NrfE; Provisional; Region: PRK10369
316401017677	12 probable transmembrane helices predicted for ETEC4384 by TMHMM2.0 at aa 21-43, 78-97, 104-126, 156-178, 191-213, 228-247, 260-282, 292-314, 335-357, 372-394, 401-423 and 526-545
316401017678	formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144
316401017679	Signal peptide predicted for ETEC4385 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.908 between residues 18 and 19
316401017680	1 probable transmembrane helix predicted for ETEC4385 by TMHMM2.0 at aa 99-121
316401017681	formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370
316401017682	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
316401017683	binding surface
316401017684	TPR motif; other site
316401017685	Signal peptide predicted for ETEC4386 by SignalP 2.0 HMM (Signal peptide probability 0.731) with cleavage site probability 0.493 between residues 28 and 29
316401017686	1 probable transmembrane helix predicted for ETEC4386 by TMHMM2.0 at aa 10-29
316401017687	glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283
316401017688	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
316401017689	10 probable transmembrane helices predicted for ETEC4387 by TMHMM2.0 at aa 7-29, 49-71, 84-106, 159-181, 202-224, 234-256, 293-310, 325-347, 354-376 and 391-409
316401017690	PS00713 Sodium:dicarboxylate symporter family signature 1.
316401017691	PS00714 Sodium:dicarboxylate symporter family signature 2.
316401017692	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
316401017693	Sel1-like repeats; Region: SEL1; smart00671
316401017694	Signal peptide predicted for ETEC4388 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 17 and 18
316401017695	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
316401017696	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
316401017697	[4Fe-4S] binding site [ion binding]; other site
316401017698	molybdopterin cofactor binding site; other site
316401017699	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
316401017700	molybdopterin cofactor binding site; other site
316401017701	PS00932 Prokaryotic molybdopterin oxidoreductases signature 3.
316401017702	PS00490 Prokaryotic molybdopterin oxidoreductases signature 2.
316401017703	PS00017 ATP/GTP-binding site motif A (P-loop).
316401017704	PS00551 Prokaryotic molybdopterin oxidoreductases signature 1.
316401017705	putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915
316401017706	Signal peptide predicted for ETEC4390 by SignalP 2.0 HMM (Signal peptide probability 0.971) with cleavage site probability 0.505 between residues 27 and 28
316401017707	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401017708	PS00443 Glutamine amidotransferases class-II active site.
316401017709	multidrug efflux system protein MdtO; Provisional; Region: PRK11427
316401017710	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
316401017711	9 probable transmembrane helices predicted for ETEC4391 by TMHMM2.0 at aa 42-64, 71-93, 103-120, 127-146, 156-178, 400-422, 426-445, 452-474 and 484-501
316401017712	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401017713	multidrug resistance protein MdtN; Provisional; Region: PRK10476
316401017714	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
316401017715	HlyD family secretion protein; Region: HlyD_3; pfam13437
316401017716	Signal peptide predicted for ETEC4392 by SignalP 2.0 HMM (Signal peptide probability 0.970) with cleavage site probability 0.608 between residues 35 and 36
316401017717	1 probable transmembrane helix predicted for ETEC4392 by TMHMM2.0 at aa 13-31
316401017718	3 probable transmembrane helices predicted for ETEC4392A by TMHMM2.0 at aa 32-54, 58-77 and 84-106
316401017719	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401017720	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
316401017721	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
316401017722	PS00225 Crystallins beta and gamma 'Greek key' motif signature.
316401017723	Signal peptide predicted for ETEC4393 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 29 and 30
316401017724	D-allose kinase; Provisional; Region: PRK09698
316401017725	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
316401017726	nucleotide binding site [chemical binding]; other site
316401017727	PS01125 ROK family signature.
316401017728	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
316401017729	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
316401017730	substrate binding site [chemical binding]; other site
316401017731	hexamer interface [polypeptide binding]; other site
316401017732	metal binding site [ion binding]; metal-binding site
316401017733	PS01086 Ribulose-phosphate 3-epimerase family signature 2.
316401017734	PS01085 Ribulose-phosphate 3-epimerase family signature 1.
316401017735	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
316401017736	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
316401017737	TM-ABC transporter signature motif; other site
316401017738	9 probable transmembrane helices predicted for ETEC4396 by TMHMM2.0 at aa 26-48, 68-90, 105-127, 134-156, 171-193, 220-242, 252-274, 279-298 and 303-320
316401017739	D-allose transporter ATP-binding protein; Provisional; Region: PRK09700
316401017740	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316401017741	Walker A/P-loop; other site
316401017742	ATP binding site [chemical binding]; other site
316401017743	Q-loop/lid; other site
316401017744	ABC transporter signature motif; other site
316401017745	Walker B; other site
316401017746	D-loop; other site
316401017747	H-loop/switch region; other site
316401017748	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
316401017749	PS00211 ABC transporters family signature.
316401017750	PS00017 ATP/GTP-binding site motif A (P-loop).
316401017751	D-allose transporter subunit; Provisional; Region: PRK09701
316401017752	Periplasmic allose-binding domain of bacterial transport systems that function as a primary receptor of active transport and chemotaxis; Region: PBP1_allose_binding; cd06320
316401017753	ligand binding site [chemical binding]; other site
316401017754	dimerization interface [polypeptide binding]; other site
316401017755	zinc binding site [ion binding]; other site
316401017756	PS00017 ATP/GTP-binding site motif A (P-loop).
316401017757	PS00030 Eukaryotic putative RNA-binding region RNP-1 signature.
316401017758	1 probable transmembrane helix predicted for ETEC4398 by TMHMM2.0 at aa 7-29
316401017759	Signal peptide predicted for ETEC4398 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.988 between residues 23 and 24
316401017760	DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337
316401017761	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
316401017762	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
316401017763	putative active site [active]
316401017764	ribose 5-phosphate isomerase B; Region: rpiB; TIGR01120
316401017765	Signal peptide predicted for ETEC4401 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 22 and 23
316401017766	carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244
316401017767	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
316401017768	Coenzyme A binding pocket [chemical binding]; other site
316401017769	ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078
316401017770	AAA domain; Region: AAA_18; pfam13238
316401017771	active site
316401017772	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
316401017773	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
316401017774	PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306
316401017775	active site
316401017776	ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778
316401017777	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
316401017778	Walker A/P-loop; other site
316401017779	ATP binding site [chemical binding]; other site
316401017780	Q-loop/lid; other site
316401017781	ABC transporter signature motif; other site
316401017782	Walker B; other site
316401017783	D-loop; other site
316401017784	H-loop/switch region; other site
316401017785	PS00211 ABC transporters family signature.
316401017786	PS00017 ATP/GTP-binding site motif A (P-loop).
316401017787	phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701
316401017788	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
316401017789	Walker A/P-loop; other site
316401017790	ATP binding site [chemical binding]; other site
316401017791	Q-loop/lid; other site
316401017792	ABC transporter signature motif; other site
316401017793	Walker B; other site
316401017794	D-loop; other site
316401017795	H-loop/switch region; other site
316401017796	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
316401017797	PS00211 ABC transporters family signature.
316401017798	PS00017 ATP/GTP-binding site motif A (P-loop).
316401017799	Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627
316401017800	Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626
316401017801	Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625
316401017802	Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754
316401017803	phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079
316401017804	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
316401017805	DNA-binding site [nucleotide binding]; DNA binding site
316401017806	UTRA domain; Region: UTRA; pfam07702
316401017807	PS00043 Bacterial regulatory proteins, gntR family signature.
316401017809	phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431
316401017810	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
316401017811	substrate binding pocket [chemical binding]; other site
316401017812	membrane-bound complex binding site; other site
316401017813	hinge residues; other site
316401017814	Signal peptide predicted for ETEC4413 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 26 and 27
316401017815	phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984
316401017816	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
316401017817	Walker A/P-loop; other site
316401017818	ATP binding site [chemical binding]; other site
316401017819	Q-loop/lid; other site
316401017820	ABC transporter signature motif; other site
316401017821	Walker B; other site
316401017822	D-loop; other site
316401017823	H-loop/switch region; other site
316401017824	PS00211 ABC transporters family signature.
316401017825	PS00017 ATP/GTP-binding site motif A (P-loop).
316401017826	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
316401017827	dimer interface [polypeptide binding]; other site
316401017828	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
316401017829	hypothetical protein; Provisional; Region: PRK10220
316401017830	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
316401017831	PhnA protein; Region: PhnA; pfam03831
316401017832	hypothetical protein; Provisional; Region: PRK09866
316401017833	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
316401017834	G1 box; other site
316401017835	GTP/Mg2+ binding site [chemical binding]; other site
316401017836	G2 box; other site
316401017837	Switch I region; other site
316401017838	G3 box; other site
316401017839	Switch II region; other site
316401017840	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
316401017841	G2 box; other site
316401017842	Switch I region; other site
316401017843	G3 box; other site
316401017844	Switch II region; other site
316401017845	G4 box; other site
316401017846	G5 box; other site
316401017847	PS00017 ATP/GTP-binding site motif A (P-loop).
316401017848	YjcZ-like protein; Region: YjcZ; pfam13990
316401017849	proline/glycine betaine transporter; Provisional; Region: PRK10642
316401017850	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401017851	putative substrate translocation pore; other site
316401017852	Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946
316401017853	12 probable transmembrane helices predicted for ETEC4419 by TMHMM2.0 at aa 30-52, 67-89, 98-117, 121-143, 168-190, 200-217, 260-282, 297-319, 326-346, 351-373, 386-408 and 418-437
316401017854	PS00216 Sugar transport proteins signature 1.
316401017855	sensor protein BasS/PmrB; Provisional; Region: PRK10755
316401017856	HAMP domain; Region: HAMP; pfam00672
316401017857	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316401017858	dimer interface [polypeptide binding]; other site
316401017859	phosphorylation site [posttranslational modification]
316401017860	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316401017861	ATP binding site [chemical binding]; other site
316401017862	Mg2+ binding site [ion binding]; other site
316401017863	G-X-G motif; other site
316401017864	2 probable transmembrane helices predicted for ETEC4420 by TMHMM2.0 at aa 15-34 and 66-88
316401017865	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
316401017866	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316401017867	active site
316401017868	phosphorylation site [posttranslational modification]
316401017869	intermolecular recognition site; other site
316401017870	dimerization interface [polypeptide binding]; other site
316401017871	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
316401017872	DNA binding site [nucleotide binding]
316401017873	PS00217 Sugar transport proteins signature 2.
316401017874	putative metal dependent hydrolase; Provisional; Region: PRK11598
316401017875	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
316401017876	Sulfatase; Region: Sulfatase; pfam00884
316401017877	5 probable transmembrane helices predicted for ETEC4422 by TMHMM2.0 at aa 12-34, 49-71, 78-100, 120-142 and 154-176
316401017878	Signal peptide predicted for ETEC4422 by SignalP 2.0 HMM (Signal peptide probability 0.874) with cleavage site probability 0.322 between residues 29 and 30
316401017879	arginine:agmatin antiporter; Provisional; Region: PRK10644
316401017880	12 probable transmembrane helices predicted for ETEC4423 by TMHMM2.0 at aa 10-32, 39-61, 94-116, 123-142, 152-171, 184-206, 226-248, 275-297, 320-342, 354-376, 386-403 and 410-428
316401017881	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
316401017882	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316401017883	PS00041 Bacterial regulatory proteins, araC family signature.
316401017884	arginine decarboxylase; Provisional; Region: PRK15029
316401017885	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
316401017886	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
316401017887	homodimer interface [polypeptide binding]; other site
316401017888	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316401017889	catalytic residue [active]
316401017890	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
316401017891	PS00703 Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site.
316401017892	DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371
316401017893	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316401017894	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316401017895	PS00041 Bacterial regulatory proteins, araC family signature.
316401017896	alpha-galactosidase; Provisional; Region: PRK15076
316401017897	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
316401017898	NAD binding site [chemical binding]; other site
316401017899	sugar binding site [chemical binding]; other site
316401017900	divalent metal binding site [ion binding]; other site
316401017901	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
316401017902	dimer interface [polypeptide binding]; other site
316401017903	PS01324 Glycosyl hydrolases family 4 signature.
316401017904	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
316401017905	Protein of unknown function (DUF433); Region: DUF433; cl01030
316401017906	MULE transposase domain; Region: MULE; pfam10551
316401017907	PS01007 Transposases, Mutator family, signature.
316401017908	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
316401017909	Protein of unknown function (DUF433); Region: DUF433; cl01030
316401017910	MULE transposase domain; Region: MULE; pfam10551
316401017911	PS01007 Transposases, Mutator family, signature.
316401017912	melibiose:sodium symporter; Provisional; Region: PRK10429
316401017913	9 probable transmembrane helices predicted for ETEC4430 by TMHMM2.0 at aa 10-32, 66-88, 92-114, 152-174, 184-206, 213-235, 240-262, 294-316 and 326-348
316401017914	hypothetical protein; Provisional; Region: PRK09867
316401017915	6 probable transmembrane helices predicted for ETEC4431 by TMHMM2.0 at aa 7-29, 33-52, 59-81, 104-121, 133-155 and 175-194
316401017916	Signal peptide predicted for ETEC4431 by SignalP 2.0 HMM (Signal peptide probability 0.968) with cleavage site probability 0.966 between residues 28 and 29
316401017917	fumarate hydratase; Provisional; Region: PRK15389
316401017918	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951
316401017919	Fumarase C-terminus; Region: Fumerase_C; pfam05683
316401017920	PS00163 Fumarate lyases signature.
316401017921	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
316401017922	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489
316401017923	11 probable transmembrane helices predicted for ETEC4433 by TMHMM2.0 at aa 21-43, 53-75, 88-110, 142-164, 171-193, 236-253, 266-288, 303-325, 346-368, 378-400 and 421-443
316401017924	DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430
316401017925	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316401017926	active site
316401017927	phosphorylation site [posttranslational modification]
316401017928	intermolecular recognition site; other site
316401017929	dimerization interface [polypeptide binding]; other site
316401017930	Transcriptional regulator; Region: CitT; pfam12431
316401017931	sensory histidine kinase DcuS; Provisional; Region: PRK11086
316401017932	PAS domain; Region: PAS; smart00091
316401017933	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316401017934	ATP binding site [chemical binding]; other site
316401017935	Mg2+ binding site [ion binding]; other site
316401017936	G-X-G motif; other site
316401017937	2 probable transmembrane helices predicted for ETEC4435 by TMHMM2.0 at aa 20-42 and 183-205
316401017938	Signal peptide predicted for ETEC4435 by SignalP 2.0 HMM (Signal peptide probability 0.984) with cleavage site probability 0.377 between residues 31 and 32
316401017939	Uncharacterized conserved protein [Function unknown]; Region: COG3592
316401017940	Predicted acetyltransferase [General function prediction only]; Region: COG2388
316401017941	Protein of unknown function (DUF2622); Region: DUF2622; pfam11080
316401017942	Protein of unknown function (DUF2566); Region: DUF2566; pfam10753
316401017943	2 probable transmembrane helices predicted for ETEC4439 by TMHMM2.0 at aa 7-24 and 34-56
316401017944	lysyl-tRNA synthetase; Reviewed; Region: PRK12445
316401017945	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
316401017946	dimer interface [polypeptide binding]; other site
316401017947	putative anticodon binding site; other site
316401017948	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
316401017949	motif 1; other site
316401017950	active site
316401017951	motif 2; other site
316401017952	motif 3; other site
316401017953	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
316401017954	PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1.
316401017955	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
316401017956	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401017957	putative substrate translocation pore; other site
316401017958	POT family; Region: PTR2; pfam00854
316401017959	14 probable transmembrane helices predicted for ETEC4441 by TMHMM2.0 at aa 9-31, 46-68, 71-93, 103-125, 138-160, 164-186, 207-229, 234-251, 264-281, 307-329, 341-360, 375-397, 404-426 and 452-474
316401017960	PS01023 PTR2 family proton/oligopeptide symporters signature 2.
316401017961	PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature.
316401017962	PS01022 PTR2 family proton/oligopeptide symporters signature 1.
316401017963	lysine decarboxylase CadA; Provisional; Region: PRK15400
316401017964	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
316401017965	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
316401017966	homodimer interface [polypeptide binding]; other site
316401017967	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316401017968	catalytic residue [active]
316401017969	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
316401017970	PS00703 Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site.
316401017971	PS00237 G-protein coupled receptors signature.
316401017972	lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435
316401017973	12 probable transmembrane helices predicted for ETEC4443 by TMHMM2.0 at aa 7-29, 39-58, 93-115, 120-142, 149-171, 186-208, 220-242, 271-293, 322-344, 354-371, 384-403 and 407-424
316401017974	Signal peptide predicted for ETEC4443 by SignalP 2.0 HMM (Signal peptide probability 0.866) with cleavage site probability 0.426 between residues 26 and 27
316401017975	DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153
316401017976	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
316401017977	DNA binding site [nucleotide binding]
316401017978	1 probable transmembrane helix predicted for ETEC4444 by TMHMM2.0 at aa 159-181
316401017979	IS1 transposase; Region: DDE_Tnp_IS1; pfam03400
316401017980	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
316401017981	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
316401017982	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
316401017983	PS00017 ATP/GTP-binding site motif A (P-loop).
316401017984	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
316401017985	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
316401017986	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
316401017987	2 probable transmembrane helices predicted for ETEC4447 by TMHMM2.0 at aa 10-31 and 227-246
316401017988	Methyltransferase domain; Region: Methyltransf_27; pfam13708
316401017989	Herpes virus major capsid protein; Region: Herpes_MCP; pfam03122
316401017990	Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117
316401017991	Protein of unknown function (DUF1219); Region: DUF1219; pfam06755
316401017992	YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154
316401017993	Protein of unknown function (DUF987); Region: DUF987; pfam06174
316401017994	DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003
316401017995	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
316401017996	MPN+ (JAMM) motif; other site
316401017997	Zinc-binding site [ion binding]; other site
316401017998	PS01302 DNA repair protein radC family signature.
316401017999	Antirestriction protein; Region: Antirestrict; pfam03230
316401018000	Domain of unknown function (DUF932); Region: DUF932; pfam06067
316401018001	Transposase; Region: HTH_Tnp_1; pfam01527
316401018002	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
316401018003	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
316401018004	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
316401018005	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
316401018006	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
316401018007	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
316401018008	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
316401018009	Signal peptide predicted for ETEC4460 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 25 and 26
316401018010	8 probable transmembrane helices predicted for ETEC4461 by TMHMM2.0 at aa 7-29, 33-52, 64-83, 98-115, 136-158, 168-187, 680-702 and 717-739
316401018011	PS00017 ATP/GTP-binding site motif A (P-loop).
316401018012	Signal peptide predicted for ETEC4461 by SignalP 2.0 HMM (Signal peptide probability 0.954) with cleavage site probability 0.415 between residues 35 and 36
316401018013	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
316401018014	Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468
316401018015	hypothetical protein; Provisional; Region: PRK09945
316401018016	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
316401018017	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
316401018018	Autotransporter beta-domain; Region: Autotransporter; smart00869
316401018019	PS00017 ATP/GTP-binding site motif A (P-loop).
316401018020	Predicted GTPase [General function prediction only]; Region: COG3596
316401018021	YfjP GTPase; Region: YfjP; cd11383
316401018022	G1 box; other site
316401018023	GTP/Mg2+ binding site [chemical binding]; other site
316401018024	Switch I region; other site
316401018025	G2 box; other site
316401018026	Switch II region; other site
316401018027	G3 box; other site
316401018028	G4 box; other site
316401018029	G5 box; other site
316401018030	PS00017 ATP/GTP-binding site motif A (P-loop).
316401018031	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
316401018032	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930
316401018033	Protein of unknown function (DUF3296); Region: DUF3296; pfam11726
316401018034	Protein of unknown function (DUF3279); Region: DUF3279; pfam11682
316401018035	PS00190 Cytochrome c family heme-binding site signature.
316401018036	Protein of unknown function (DUF3279); Region: DUF3279; pfam11682
316401018037	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
316401018038	Transposase; Region: HTH_Tnp_1; pfam01527
316401018039	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
316401018040	Protein of unknown function (DUF433); Region: DUF433; cl01030
316401018041	MULE transposase domain; Region: MULE; pfam10551
316401018042	PS01007 Transposases, Mutator family, signature.
316401018043	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
316401018044	Helix-turn-helix domain; Region: HTH_38; pfam13936
316401018045	Integrase core domain; Region: rve; pfam00665
316401018046	PS01043 Transposases, IS30 family, signature.
316401018047	putative transposase OrfB; Reviewed; Region: PHA02517
316401018048	HTH-like domain; Region: HTH_21; pfam13276
316401018049	Integrase core domain; Region: rve; pfam00665
316401018050	Integrase core domain; Region: rve_2; pfam13333
316401018051	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
316401018052	PS00017 ATP/GTP-binding site motif A (P-loop).
316401018053	McrBC 5-methylcytosine restriction system component; Region: McrBC; pfam10117
316401018054	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
316401018055	HsdM N-terminal domain; Region: HsdM_N; pfam12161
316401018056	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
316401018057	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
316401018058	PS00092 N-6 Adenine-specific DNA methylases signature.
316401018059	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316401018060	S-adenosylmethionine binding site [chemical binding]; other site
316401018061	PS00092 N-6 Adenine-specific DNA methylases signature.
316401018062	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
316401018063	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
316401018064	active site
316401018065	Int/Topo IB signature motif; other site
316401018066	PS00018 EF-hand calcium-binding domain.
316401018067	putative transcriptional regulator; Provisional; Region: PRK11640
316401018068	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
316401018069	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
316401018070	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
316401018071	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
316401018072	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
316401018073	DsbD alpha interface [polypeptide binding]; other site
316401018074	catalytic residues [active]
316401018075	PS00194 Thioredoxin family active site.
316401018076	8 probable transmembrane helices predicted for ETEC4483 by TMHMM2.0 at aa 5-22, 165-187, 207-229, 242-264, 294-316, 323-345, 360-377 and 384-406
316401018077	Signal peptide predicted for ETEC4483 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 19 and 20
316401018078	divalent-cation tolerance protein CutA; Provisional; Region: PRK10645
316401018079	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
316401018080	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
316401018081	11 probable transmembrane helices predicted for ETEC4485 by TMHMM2.0 at aa 15-37, 50-72, 87-109, 130-152, 162-184, 226-243, 258-277, 284-306, 326-345, 358-380 and 410-432
316401018082	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
316401018083	Aspartase; Region: Aspartase; cd01357
316401018084	active sites [active]
316401018085	tetramer interface [polypeptide binding]; other site
316401018086	PS00163 Fumarate lyases signature.
316401018087	Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030
316401018088	3 probable transmembrane helices predicted for ETEC4487 by TMHMM2.0 at aa 4-21, 26-48 and 79-101
316401018089	putative transporter; Provisional; Region: PRK11021
316401018090	11 probable transmembrane helices predicted for ETEC4488 by TMHMM2.0 at aa 13-35, 45-67, 87-109, 114-136, 143-165, 185-207, 220-242, 265-287, 316-338, 343-365 and 372-406
316401018091	Signal peptide predicted for ETEC4488 by SignalP 2.0 HMM (Signal peptide probability 0.988) with cleavage site probability 0.957 between residues 33 and 34
316401018092	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
316401018093	oligomerisation interface [polypeptide binding]; other site
316401018094	mobile loop; other site
316401018095	roof hairpin; other site
316401018096	PS00681 Chaperonins cpn10 signature.
316401018097	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
316401018098	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
316401018099	ring oligomerisation interface [polypeptide binding]; other site
316401018100	ATP/Mg binding site [chemical binding]; other site
316401018101	stacking interactions; other site
316401018102	hinge regions; other site
316401018103	PS00296 Chaperonins cpn60 signature.
316401018104	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
316401018105	Signal peptide predicted for ETEC4491 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.381 between residues 27 and 28
316401018106	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401018107	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
316401018108	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316401018109	FeS/SAM binding site; other site
316401018110	elongation factor P; Validated; Region: PRK00529
316401018111	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
316401018112	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
316401018113	RNA binding site [nucleotide binding]; other site
316401018114	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
316401018115	RNA binding site [nucleotide binding]; other site
316401018116	PS01275 Elongation factor P signature.
316401018117	entericidin A; Provisional; Region: PRK09810
316401018118	Signal peptide predicted for ETEC4495 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.770 between residues 24 and 25
316401018119	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401018120	entericidin B membrane lipoprotein; Provisional; Region: PRK10081
316401018121	Signal peptide predicted for ETEC4496 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.992 between residues 21 and 22
316401018122	1 probable transmembrane helix predicted for ETEC4496 by TMHMM2.0 at aa 7-29
316401018123	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401018124	multidrug efflux system protein; Provisional; Region: PRK11431
316401018125	4 probable transmembrane helices predicted for ETEC4497 by TMHMM2.0 at aa 2-19, 29-48, 55-77 and 87-104
316401018126	Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040
316401018127	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
316401018128	PS00225 Crystallins beta and gamma 'Greek key' motif signature.
316401018129	PS00213 Lipocalin signature.
316401018130	Signal peptide predicted for ETEC4498 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.645 between residues 18 and 19
316401018131	beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289
316401018132	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
316401018133	PS00336 Beta-lactamase class-C active site.
316401018134	Signal peptide predicted for ETEC4499 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 19 and 20
316401018135	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401018136	Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547
316401018137	Iron-sulfur protein interface; other site
316401018138	proximal quinone binding site [chemical binding]; other site
316401018139	C-subunit interface; other site
316401018140	distal quinone binding site; other site
316401018141	3 probable transmembrane helices predicted for ETEC4500 by TMHMM2.0 at aa 13-46, 56-78 and 99-118
316401018142	Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546
316401018143	D-subunit interface [polypeptide binding]; other site
316401018144	Iron-sulfur protein interface; other site
316401018145	proximal quinone binding site [chemical binding]; other site
316401018146	distal quinone binding site [chemical binding]; other site
316401018147	3 probable transmembrane helices predicted for ETEC4501 by TMHMM2.0 at aa 27-49, 69-91 and 112-130
316401018148	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385
316401018149	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
316401018150	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401018151	PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature.
316401018152	fumarate reductase flavoprotein subunit; Validated; Region: PRK09231
316401018153	L-aspartate oxidase; Provisional; Region: PRK06175
316401018154	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
316401018155	PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site.
316401018156	Signal peptide predicted for ETEC4503 by SignalP 2.0 HMM (Signal peptide probability 0.910) with cleavage site probability 0.338 between residues 27 and 28
316401018157	poxB regulator PoxA; Provisional; Region: PRK09350
316401018158	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
316401018159	motif 1; other site
316401018160	dimer interface [polypeptide binding]; other site
316401018161	active site
316401018162	motif 2; other site
316401018163	motif 3; other site
316401018164	PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1.
316401018165	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
316401018166	inner membrane transporter YjeM; Provisional; Region: PRK15238
316401018167	Signal peptide predicted for ETEC4505 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.886 between residues 25 and 26
316401018168	12 probable transmembrane helices predicted for ETEC4505 by TMHMM2.0 at aa 9-31, 36-58, 79-101, 128-150, 162-184, 208-230, 243-265, 310-332, 361-383, 393-415, 435-457 and 467-484
316401018169	Protein of unknown function (DUF2645); Region: DUF2645; pfam10840
316401018170	Signal peptide predicted for ETEC4507 by SignalP 2.0 HMM (Signal peptide probability 0.819) with cleavage site probability 0.791 between residues 25 and 26
316401018171	3 probable transmembrane helices predicted for ETEC4507 by TMHMM2.0 at aa 7-26, 55-72 and 79-98
316401018172	putative mechanosensitive channel protein; Provisional; Region: PRK10929
316401018173	linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073
316401018174	DNA-binding site [nucleotide binding]; DNA binding site
316401018175	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
316401018176	Mechanosensitive ion channel; Region: MS_channel; pfam00924
316401018177	PS01246 Uncharacterized protein family UPF0003 signature.
316401018178	11 probable transmembrane helices predicted for ETEC4508 by TMHMM2.0 at aa 476-495, 516-538, 553-575, 596-617, 627-649, 670-692, 696-718, 784-806, 826-848, 879-898 and 908-930
316401018179	Signal peptide predicted for ETEC4508 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.992 between residues 19 and 20
316401018180	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
316401018181	GTPase RsgA; Reviewed; Region: PRK12288
316401018182	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
316401018183	RNA binding site [nucleotide binding]; other site
316401018184	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
316401018185	GTPase/Zn-binding domain interface [polypeptide binding]; other site
316401018186	GTP/Mg2+ binding site [chemical binding]; other site
316401018187	G4 box; other site
316401018188	G5 box; other site
316401018189	G1 box; other site
316401018190	Switch I region; other site
316401018191	G2 box; other site
316401018192	G3 box; other site
316401018193	Switch II region; other site
316401018194	PS00017 ATP/GTP-binding site motif A (P-loop).
316401018195	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
316401018196	catalytic site [active]
316401018197	putative active site [active]
316401018198	putative substrate binding site [chemical binding]; other site
316401018199	dimer interface [polypeptide binding]; other site
316401018200	epoxyqueuosine reductase; Region: TIGR00276
316401018201	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
316401018202	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401018203	putative carbohydrate kinase; Provisional; Region: PRK10565
316401018204	yjeF N-terminal region; Region: yjeF_nterm; TIGR00197
316401018205	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
316401018206	putative substrate binding site [chemical binding]; other site
316401018207	putative ATP binding site [chemical binding]; other site
316401018208	PS00147 Arginase family signature 1.
316401018209	PS01049 Uncharacterized protein family UPF0031 signature 1.
316401018210	PS01050 Uncharacterized protein family UPF0031 signature 2.
316401018211	ADP-binding protein; Provisional; Region: PRK10646
316401018212	PS00017 ATP/GTP-binding site motif A (P-loop).
316401018213	N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431
316401018214	AMIN domain; Region: AMIN; pfam11741
316401018215	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
316401018216	active site
316401018217	metal binding site [ion binding]; metal-binding site
316401018218	Signal peptide predicted for ETEC4515 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.984 between residues 22 and 23
316401018219	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
316401018220	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316401018221	ATP binding site [chemical binding]; other site
316401018222	Mg2+ binding site [ion binding]; other site
316401018223	G-X-G motif; other site
316401018224	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
316401018225	ATP binding site [chemical binding]; other site
316401018226	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
316401018227	PS00058 DNA mismatch repair proteins mutL / hexB / PMS1 signature.
316401018228	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
316401018229	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
316401018230	PS00017 ATP/GTP-binding site motif A (P-loop).
316401018231	bacterial Hfq-like; Region: Hfq; cd01716
316401018232	hexamer interface [polypeptide binding]; other site
316401018233	Sm1 motif; other site
316401018234	RNA binding site [nucleotide binding]; other site
316401018235	Sm2 motif; other site
316401018236	GTPase HflX; Provisional; Region: PRK11058
316401018237	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
316401018238	HflX GTPase family; Region: HflX; cd01878
316401018239	G1 box; other site
316401018240	GTP/Mg2+ binding site [chemical binding]; other site
316401018241	Switch I region; other site
316401018242	G2 box; other site
316401018243	G3 box; other site
316401018244	Switch II region; other site
316401018245	G4 box; other site
316401018246	G5 box; other site
316401018247	PS00017 ATP/GTP-binding site motif A (P-loop).
316401018248	FtsH protease regulator HflK; Provisional; Region: PRK10930
316401018249	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
316401018250	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
316401018251	1 probable transmembrane helix predicted for ETEC4520 by TMHMM2.0 at aa 76-98
316401018252	FtsH protease regulator HflC; Provisional; Region: PRK11029
316401018253	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
316401018254	Signal peptide predicted for ETEC4521 by SignalP 2.0 HMM (Signal peptide probability 0.723) with cleavage site probability 0.456 between residues 24 and 25
316401018255	1 probable transmembrane helix predicted for ETEC4521 by TMHMM2.0 at aa 5-23
316401018256	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242
316401018257	2 probable transmembrane helices predicted for ETEC4522 by TMHMM2.0 at aa 5-27 and 42-60
316401018258	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
316401018259	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
316401018260	GDP-binding site [chemical binding]; other site
316401018261	ACT binding site; other site
316401018262	IMP binding site; other site
316401018263	PS01266 Adenylosuccinate synthetase GTP-binding site.
316401018264	PS00513 Adenylosuccinate synthetase active site.
316401018265	Predicted transcriptional regulator [Transcription]; Region: COG1959
316401018266	transcriptional repressor NsrR; Provisional; Region: PRK11014
316401018267	PS01332 Uncharacterized protein family UPF0074 signature.
316401018268	PS00017 ATP/GTP-binding site motif A (P-loop).
316401018269	exoribonuclease R; Provisional; Region: PRK11642
316401018270	Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461
316401018271	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
316401018272	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
316401018273	RNB domain; Region: RNB; pfam00773
316401018274	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
316401018275	RNA binding site [nucleotide binding]; other site
316401018276	PS01175 Ribonuclease II family signature.
316401018277	PS00017 ATP/GTP-binding site motif A (P-loop).
316401018278	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
316401018279	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
316401018280	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
316401018281	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3789
316401018282	PspA/IM30 family; Region: PspA_IM30; pfam04012
316401018283	Protein of unknown function (DUF2491); Region: DUF2491; pfam10679
316401018284	Predicted membrane protein [Function unknown]; Region: COG3766
316401018285	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
316401018286	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
316401018287	4 probable transmembrane helices predicted for ETEC4530 by TMHMM2.0 at aa 6-28, 48-70, 75-97 and 104-126
316401018288	Protein of unknown function (DUF1190); Region: DUF1190; cl10031
316401018289	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
316401018290	PS00107 Protein kinases ATP-binding region signature.
316401018291	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
316401018292	Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154
316401018293	FAD binding site [chemical binding]; other site
316401018294	substrate binding site [chemical binding]; other site
316401018295	catalytic residues [active]
316401018296	PS00072 Acyl-CoA dehydrogenases signature 1.
316401018297	PS00073 Acyl-CoA dehydrogenases signature 2.
316401018298	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
316401018299	Signal peptide predicted for ETEC4534 by SignalP 2.0 HMM (Signal peptide probability 0.988) with cleavage site probability 0.757 between residues 21 and 22
316401018300	putative biofilm stress and motility protein A; Provisional; Region: PRK14864
316401018301	1 probable transmembrane helix predicted for ETEC4535 by TMHMM2.0 at aa 9-31
316401018302	Signal peptide predicted for ETEC4535 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.505 between residues 30 and 31
316401018303	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401018304	esterase; Provisional; Region: PRK10566
316401018305	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
316401018306	transcriptional repressor UlaR; Provisional; Region: PRK13509
316401018307	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
316401018308	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
316401018309	PS00894 Bacterial regulatory proteins, deoR family signature.
316401018310	Similar to C-terminus of Escherichia coli O157:H7 UlaG probable l-ascorbate-6-phosphate lactonase UlaG (ec 3.1.1.-) (l- ascorbate utilization protein g). UniProt:Q8XDJ6 (354 aa) fasta scores: E()=2e-77, 100.000% id in 192 aa
316401018311	Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037
316401018312	PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548
316401018313	10 probable transmembrane helices predicted for ETEC4539 by TMHMM2.0 at aa 15-34, 41-63, 99-121, 141-172, 233-252, 264-286, 306-328, 340-362, 377-399 and 424-446
316401018314	PS00225 Crystallins beta and gamma 'Greek key' motif signature.
316401018315	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
316401018316	active site
316401018317	P-loop; other site
316401018318	phosphorylation site [posttranslational modification]
316401018319	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
316401018320	active site
316401018321	phosphorylation site [posttranslational modification]
316401018322	PS00372 PTS EIIA domains phosphorylation site signature 2.
316401018323	PS00387 Inorganic pyrophosphatase signature.
316401018324	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
316401018325	active site
316401018326	dimer interface [polypeptide binding]; other site
316401018327	magnesium binding site [ion binding]; other site
316401018328	L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209
316401018329	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
316401018330	AP (apurinic/apyrimidinic) site pocket; other site
316401018331	DNA interaction; other site
316401018332	Metal-binding active site; metal-binding site
316401018333	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
316401018334	1 probable transmembrane helix predicted for ETEC4545 by TMHMM2.0 at aa 5-22
316401018335	Signal peptide predicted for ETEC4545 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 20 and 21
316401018336	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
316401018337	PS01048 Ribosomal protein S6 signature.
316401018338	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
316401018339	dimer interface [polypeptide binding]; other site
316401018340	ssDNA binding site [nucleotide binding]; other site
316401018341	tetramer (dimer of dimers) interface [polypeptide binding]; other site
316401018342	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
316401018343	PS00057 Ribosomal protein S18 signature.
316401018344	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
316401018345	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
316401018346	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
316401018347	PS00651 Ribosomal protein L9 signature.
316401018348	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
316401018349	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
316401018350	Signal peptide predicted for ETEC4550 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 23 and 24
316401018351	DctM-like transporters; Region: DctM; pfam06808
316401018352	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
316401018353	11 probable transmembrane helices predicted for ETEC4551 by TMHMM2.0 at aa 7-29, 59-81, 102-124, 174-196, 217-239, 249-268, 275-297, 312-334, 341-358, 368-390 and 403-425
316401018354	Signal peptide predicted for ETEC4551 by SignalP 2.0 HMM (Signal peptide probability 0.800) with cleavage site probability 0.537 between residues 27 and 28
316401018355	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
316401018356	4 probable transmembrane helices predicted for ETEC4552 by TMHMM2.0 at aa 17-39, 54-71, 92-114 and 129-151
316401018357	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401018358	Signal peptide predicted for ETEC4552 by SignalP 2.0 HMM (Signal peptide probability 0.697) with cleavage site probability 0.263 between residues 31 and 32
316401018359	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053
316401018360	L-aspartate oxidase; Provisional; Region: PRK06175
316401018361	L-aspartate oxidase; Provisional; Region: PRK06175
316401018362	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
316401018363	Coenzyme A transferase; Region: CoA_trans; smart00882
316401018364	Coenzyme A transferase; Region: CoA_trans; cl17247
316401018365	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
316401018366	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
316401018367	substrate binding site [chemical binding]; other site
316401018368	oxyanion hole (OAH) forming residues; other site
316401018369	trimer interface [polypeptide binding]; other site
316401018370	PS00166 Enoyl-CoA hydratase/isomerase signature.
316401018371	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
316401018372	PS00228 Tubulin-beta mRNA autoregulation signal.
316401018373	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745
316401018374	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 1, classical (c) SDR; Region: BKR_1_SDR_c; cd05337
316401018375	putative NAD(P) binding site [chemical binding]; other site
316401018376	active site
316401018377	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
316401018378	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
316401018379	Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061
316401018380	Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525
316401018381	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
316401018382	peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570
316401018383	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
316401018384	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
316401018385	PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1.
316401018386	PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2.
316401018387	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
316401018388	12 probable transmembrane helices predicted for ETEC4561 by TMHMM2.0 at aa 27-44, 49-71, 104-126, 136-158, 165-187, 210-232, 252-274, 289-311, 342-364, 374-396, 417-435 and 439-461
316401018389	PS00218 Amino acid permeases signature.
316401018390	iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992
316401018391	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
316401018392	Hemerythrin-like domain; Region: Hr-like; cd12108
316401018393	Fe binding site [ion binding]; other site
316401018394	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
316401018395	EamA-like transporter family; Region: EamA; pfam00892
316401018396	10 probable transmembrane helices predicted for ETEC4563 by TMHMM2.0 at aa 7-29, 33-55, 67-89, 94-116, 123-145, 155-177, 198-220, 235-257, 264-286 and 290-309
316401018397	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
316401018398	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
316401018399	NADP binding site [chemical binding]; other site
316401018400	Predicted transcriptional regulators [Transcription]; Region: COG1733
316401018401	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
316401018402	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
316401018403	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
316401018404	active site
316401018405	metal binding site [ion binding]; metal-binding site
316401018406	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
316401018407	PS00786 5'-nucleotidase signature 2.
316401018408	PS00785 5'-nucleotidase signature 1.
316401018409	Signal peptide predicted for ETEC4566 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 19 and 20
316401018410	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
316401018411	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
316401018412	active site
316401018413	PS00629 Inositol monophosphatase family signature 1.
316401018414	PS00630 Inositol monophosphatase family signature 2.
316401018415	Predicted transcriptional regulator [General function prediction only]; Region: COG3054
316401018416	Signal peptide predicted for ETEC4568 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.770 between residues 20 and 21
316401018417	Protein of unknown function (DUF1107); Region: DUF1107; pfam06526
316401018418	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
316401018419	Domain of unknown function DUF21; Region: DUF21; pfam01595
316401018420	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
316401018421	Transporter associated domain; Region: CorC_HlyC; smart01091
316401018422	4 probable transmembrane helices predicted for ETEC4570 by TMHMM2.0 at aa 5-27, 58-80, 100-117 and 142-164
316401018423	Signal peptide predicted for ETEC4570 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.953 between residues 26 and 27
316401018424	methionine sulfoxide reductase A; Provisional; Region: PRK00058
316401018425	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
316401018426	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
316401018427	Surface antigen; Region: Bac_surface_Ag; pfam01103
316401018428	Signal peptide predicted for ETEC4572 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.995 between residues 21 and 22
316401018429	PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide.
316401018430	PS00213 Lipocalin signature.
316401018431	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
316401018432	Family of unknown function (DUF490); Region: DUF490; pfam04357
316401018433	Signal peptide predicted for ETEC4573 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.724 between residues 25 and 26
316401018434	1 probable transmembrane helix predicted for ETEC4573 by TMHMM2.0 at aa 7-29
316401018435	PS00213 Lipocalin signature.
316401018436	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
316401018437	putative active site pocket [active]
316401018438	dimerization interface [polypeptide binding]; other site
316401018439	putative catalytic residue [active]
316401018440	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
316401018441	dimer interface [polypeptide binding]; other site
316401018442	substrate binding site [chemical binding]; other site
316401018443	metal binding sites [ion binding]; metal-binding site
316401018444	PS00387 Inorganic pyrophosphatase signature.
316401018445	Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309
316401018446	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
316401018447	putative ligand binding site [chemical binding]; other site
316401018448	Signal peptide predicted for ETEC4576 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.986 between residues 21 and 22
316401018449	PS00063 Aldo/keto reductase family putative active site signature.
316401018450	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
316401018451	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
316401018452	Walker A/P-loop; other site
316401018453	ATP binding site [chemical binding]; other site
316401018454	Q-loop/lid; other site
316401018455	ABC transporter signature motif; other site
316401018456	Walker B; other site
316401018457	D-loop; other site
316401018458	H-loop/switch region; other site
316401018459	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
316401018460	PS00017 ATP/GTP-binding site motif A (P-loop).
316401018461	PS00211 ABC transporters family signature.
316401018462	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
316401018463	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
316401018464	TM-ABC transporter signature motif; other site
316401018465	9 probable transmembrane helices predicted for ETEC4578 by TMHMM2.0 at aa 24-46, 59-81, 101-123, 136-158, 173-195, 223-245, 255-274, 281-303 and 313-330
316401018466	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
316401018467	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
316401018468	TM-ABC transporter signature motif; other site
316401018469	Signal peptide predicted for ETEC4579 by SignalP 2.0 HMM (Signal peptide probability 0.610) with cleavage site probability 0.544 between residues 30 and 31
316401018470	8 probable transmembrane helices predicted for ETEC4579 by TMHMM2.0 at aa 10-32, 44-77, 87-109, 116-135, 158-180, 210-232, 247-269 and 290-312
316401018471	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
316401018472	AMP binding site [chemical binding]; other site
316401018473	metal binding site [ion binding]; metal-binding site
316401018474	active site
316401018475	PS00124 Fructose-1-6-bisphosphatase active site.
316401018476	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
316401018477	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
316401018478	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
316401018479	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
316401018480	Signal peptide predicted for ETEC4581 by SignalP 2.0 HMM (Signal peptide probability 0.736) with cleavage site probability 0.461 between residues 24 and 25
316401018481	hypothetical protein; Provisional; Region: PRK05255
316401018482	peptidase PmbA; Provisional; Region: PRK11040
316401018483	Cytochrome b562; Region: Cytochrom_B562; cl01546
316401018484	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
316401018485	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316401018486	FeS/SAM binding site; other site
316401018487	PS01087 Radical activating enzymes signature.
316401018488	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
316401018489	ATP cone domain; Region: ATP-cone; pfam03477
316401018490	Class III ribonucleotide reductase; Region: RNR_III; cd01675
316401018491	effector binding site; other site
316401018492	active site
316401018493	Zn binding site [ion binding]; other site
316401018494	glycine loop; other site
316401018495	PS00850 Glycine radical signature.
316401018496	trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933
316401018497	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
316401018498	Ca binding site [ion binding]; other site
316401018499	active site
316401018500	catalytic site [active]
316401018501	PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007
316401018502	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
316401018503	active site turn [active]
316401018504	phosphorylation site [posttranslational modification]
316401018505	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
316401018506	10 probable transmembrane helices predicted for ETEC4588 by TMHMM2.0 at aa 107-129, 155-177, 184-206, 226-245, 257-279, 299-321, 342-361, 371-393, 406-428 and 438-460
316401018507	PS01035 PTS EIIB domains cysteine phosphorylation site signature.
316401018508	trehalose repressor; Provisional; Region: treR; PRK09492
316401018509	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
316401018510	DNA binding site [nucleotide binding]
316401018511	domain linker motif; other site
316401018512	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
316401018513	dimerization interface [polypeptide binding]; other site
316401018514	ligand binding site [chemical binding]; other site
316401018515	PS00356 Bacterial regulatory proteins, lacI family signature.
316401018516	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
316401018517	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
316401018518	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
316401018519	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
316401018520	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
316401018521	motif II; other site
316401018522	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
316401018523	7 probable transmembrane helices predicted for ETEC4590 by TMHMM2.0 at aa 118-137, 291-310, 320-342, 710-732, 769-791, 832-854 and 869-891
316401018524	PS00154 E1-E2 ATPases phosphorylation site.
316401018525	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
316401018526	homotrimer interaction site [polypeptide binding]; other site
316401018527	putative active site [active]
316401018528	PS01094 Uncharacterized protein family UPF0076 signature.
316401018529	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
316401018530	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
316401018531	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
316401018532	aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670
316401018533	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
316401018534	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
316401018535	PS00097 Aspartate and ornithine carbamoyltransferases signature.
316401018536	PyrBI operon leader peptide; Region: PyrBI_leader; pfam08052
316401018537	YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198
316401018538	homotrimer interaction site [polypeptide binding]; other site
316401018539	putative active site [active]
316401018540	oxidoreductase; Provisional; Region: PRK12742
316401018541	classical (c) SDRs; Region: SDR_c; cd05233
316401018542	NAD(P) binding site [chemical binding]; other site
316401018543	active site
316401018544	PS00061 Short-chain dehydrogenases/reductases family signature.
316401018545	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
316401018546	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
316401018547	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
316401018548	SopA-like central domain; Region: SopA; pfam13981
316401018549	ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515
316401018550	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
316401018551	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
316401018552	PS00097 Aspartate and ornithine carbamoyltransferases signature.
316401018553	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076
316401018554	RNase E inhibitor protein; Provisional; Region: PRK11191
316401018555	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
316401018556	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
316401018557	Coenzyme A binding pocket [chemical binding]; other site
316401018558	Predicted membrane protein [Function unknown]; Region: COG4269
316401018559	8 probable transmembrane helices predicted for ETEC4603 by TMHMM2.0 at aa 25-47, 67-89, 96-115, 141-163, 176-198, 227-249, 279-301 and 327-349
316401018560	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
316401018561	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
316401018562	HIGH motif; other site
316401018563	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
316401018564	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
316401018565	active site
316401018566	KMSKS motif; other site
316401018567	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
316401018568	tRNA binding surface [nucleotide binding]; other site
316401018569	anticodon binding site; other site
316401018570	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
316401018571	PS00178 Aminoacyl-transfer RNA synthetases class-I signature.
316401018572	DNA polymerase III subunit chi; Validated; Region: PRK05728
316401018573	multifunctional aminopeptidase A; Provisional; Region: PRK00913
316401018574	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
316401018575	interface (dimer of trimers) [polypeptide binding]; other site
316401018576	Substrate-binding/catalytic site; other site
316401018577	Zn-binding sites [ion binding]; other site
316401018578	PS00631 Cytosol aminopeptidase signature.
316401018579	lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120
316401018580	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
316401018581	6 probable transmembrane helices predicted for ETEC4607 by TMHMM2.0 at aa 17-39, 54-76, 97-119, 267-289, 296-314 and 329-348
316401018582	lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071
316401018583	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
316401018584	6 probable transmembrane helices predicted for ETEC4608 by TMHMM2.0 at aa 10-32, 64-83, 103-125, 279-301, 305-322 and 329-351
316401018585	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
316401018586	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
316401018587	Walker A motif; other site
316401018588	ATP binding site [chemical binding]; other site
316401018589	PS00017 ATP/GTP-binding site motif A (P-loop).
316401018590	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
316401018591	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
316401018592	putative NAD(P) binding site [chemical binding]; other site
316401018593	putative substrate binding site [chemical binding]; other site
316401018594	catalytic Zn binding site [ion binding]; other site
316401018595	structural Zn binding site [ion binding]; other site
316401018596	dimer interface [polypeptide binding]; other site
316401018597	PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature.
316401018598	PS00059 Zinc-containing alcohol dehydrogenases signature.
316401018599	PS00190 Cytochrome c family heme-binding site signature.
316401018600	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
316401018601	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
316401018602	active site
316401018603	Int/Topo IB signature motif; other site
316401018604	PS00018 EF-hand calcium-binding domain.
316401018605	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
316401018606	Sulfatase; Region: Sulfatase; cl17466
316401018607	1 probable transmembrane helix predicted for ETEC4612 by TMHMM2.0 at aa 5-27
316401018608	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
316401018609	putative sialic acid transporter; Provisional; Region: PRK12307
316401018610	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401018611	putative substrate translocation pore; other site
316401018612	11 probable transmembrane helices predicted for ETEC4614 by TMHMM2.0 at aa 21-40, 50-72, 85-107, 140-159, 166-185, 217-239, 251-273, 283-302, 309-331, 346-368 and 370-392
316401018613	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
316401018614	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
316401018615	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
316401018616	D-galactonate transporter; Region: 2A0114; TIGR00893
316401018617	2 probable transmembrane helices predicted for ETEC4617 by TMHMM2.0 at aa 25-47 and 54-76
316401018618	Transposase; Region: DEDD_Tnp_IS110; pfam01548
316401018619	IS1 transposase; Region: DDE_Tnp_IS1; pfam03400
316401018620	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
316401018621	AAA domain; Region: AAA_12; pfam13087
316401018622	C-terminal domain of Escherichia coli uncharacterized protein yjhR and similar proteins; Region: PLDc_yjhR_C_like; cd09118
316401018623	putative active site [active]
316401018624	catalytic site [active]
316401018625	Domain of unknown function (DUF303); Region: DUF303; pfam03629
316401018626	N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131
316401018627	Kelch motif; Region: Kelch_1; pfam01344
316401018628	Signal peptide predicted for ETEC4622 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.992 between residues 19 and 20
316401018629	Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629
316401018630	Signal peptide predicted for ETEC4623 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.976 between residues 23 and 24
316401018631	FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197
316401018632	Int/Topo IB signature motif; other site
316401018633	FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197
316401018634	Int/Topo IB signature motif; other site
316401018635	Fimbrial protein; Region: Fimbrial; cl01416
316401018636	Signal peptide predicted for ETEC4626 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 23 and 24
316401018637	1 probable transmembrane helix predicted for ETEC4626 by TMHMM2.0 at aa 7-29
316401018638	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
316401018639	Signal peptide predicted for ETEC4627 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.974 between residues 19 and 20
316401018640	fimbrial chaperone protein FimC; Provisional; Region: PRK15195
316401018641	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
316401018642	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
316401018643	Signal peptide predicted for ETEC4628 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.643 between residues 36 and 37
316401018644	1 probable transmembrane helix predicted for ETEC4628 by TMHMM2.0 at aa 13-32
316401018645	PS00635 Gram-negative pili assembly chaperone signature.
316401018646	outer membrane usher protein; Provisional; Region: PRK15193
316401018647	PapC N-terminal domain; Region: PapC_N; pfam13954
316401018648	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
316401018649	PapC C-terminal domain; Region: PapC_C; pfam13953
316401018650	Signal peptide predicted for ETEC4629 by SignalP 2.0 HMM (Signal peptide probability 0.987) with cleavage site probability 0.855 between residues 37 and 38
316401018651	1 probable transmembrane helix predicted for ETEC4629 by TMHMM2.0 at aa 21-43
316401018652	PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1.
316401018653	PS01151 Fimbrial biogenesis outer membrane usher protein signature.
316401018654	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
316401018655	Signal peptide predicted for ETEC4630 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.919 between residues 22 and 23
316401018656	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
316401018657	Signal peptide predicted for ETEC4631 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.988 between residues 23 and 24
316401018658	1 probable transmembrane helix predicted for ETEC4631 by TMHMM2.0 at aa 7-29
316401018659	Mannose binding  domain of FimH and related proteins; Region: FimH_man-bind; cd10466
316401018660	mannosyl binding site [chemical binding]; other site
316401018661	Fimbrial protein; Region: Fimbrial; pfam00419
316401018662	Signal peptide predicted for ETEC4632 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.717 between residues 19 and 20
316401018663	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
316401018664	fructuronate transporter; Provisional; Region: PRK10034
316401018665	gluconate transporter; Region: gntP; TIGR00791
316401018666	13 probable transmembrane helices predicted for ETEC4633 by TMHMM2.0 at aa 4-21, 28-50, 55-74, 95-117, 122-144, 174-196, 227-249, 261-283, 298-315, 328-350, 354-373, 380-402 and 424-446
316401018667	mannonate dehydratase; Region: uxuA; TIGR00695
316401018668	mannonate dehydratase; Provisional; Region: PRK03906
316401018669	D-mannonate oxidoreductase; Provisional; Region: PRK15037
316401018670	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
316401018671	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
316401018672	PS00974 Mannitol dehydrogenases signature.
316401018673	DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225
316401018674	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
316401018675	DNA-binding site [nucleotide binding]; DNA binding site
316401018676	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
316401018677	PS00043 Bacterial regulatory proteins, gntR family signature.
316401018678	IS1 transposase; Region: DDE_Tnp_IS1; pfam03400
316401018679	Protein of unknown function (DUF2686); Region: DUF2686; pfam10887
316401018680	DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128
316401018681	cell density-dependent motility repressor; Provisional; Region: PRK10082
316401018682	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316401018683	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
316401018684	PS00044 Bacterial regulatory proteins, lysR family signature.
316401018685	Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308
316401018686	isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975
316401018687	dimer interface [polypeptide binding]; other site
316401018688	active site
316401018689	hypothetical protein; Provisional; Region: PRK10519
316401018690	3 probable transmembrane helices predicted for ETEC4642 by TMHMM2.0 at aa 20-42, 68-90 and 130-152
316401018691	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
316401018692	Nucleoside recognition; Region: Gate; pfam07670
316401018693	4 probable transmembrane helices predicted for ETEC4643 by TMHMM2.0 at aa 21-43, 80-99, 112-134 and 179-201
316401018694	RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
316401018695	RNA 2'-phosphotransferase; Reviewed; Region: PRK00819
316401018696	Protein of unknown function (DUF1228); Region: DUF1228; pfam06779
316401018697	12 probable transmembrane helices predicted for ETEC4645 by TMHMM2.0 at aa 12-34, 54-76, 83-105, 109-131, 138-160, 170-192, 212-234, 244-266, 271-293, 298-320, 333-355 and 360-382
316401018698	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204
316401018699	SdiA-regulated; Region: SdiA-regulated; cd09971
316401018700	putative active site [active]
316401018701	2 probable transmembrane helices predicted for ETEC4646 by TMHMM2.0 at aa 21-43 and 47-64
316401018702	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
316401018703	CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241
316401018704	Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775
316401018705	benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263
316401018706	Predicted membrane protein [Function unknown]; Region: COG2733
316401018707	3 probable transmembrane helices predicted for ETEC4649 by TMHMM2.0 at aa 13-32, 42-62 and 398-420
316401018708	Signal peptide predicted for ETEC4649 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.411 between residues 26 and 27
316401018709	Protein of unknown function (DUF2623); Region: DUF2623; pfam11115
316401018710	multidrug efflux system protein MdtM; Provisional; Region: PRK15403
316401018711	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401018712	putative substrate translocation pore; other site
316401018713	12 probable transmembrane helices predicted for ETEC4650 by TMHMM2.0 at aa 21-43, 58-77, 89-108, 113-135, 147-169, 173-195, 225-247, 262-284, 291-313, 318-340, 353-375 and 385-404
316401018714	PS00216 Sugar transport proteins signature 1.
316401018715	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
316401018716	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
316401018717	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
316401018718	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929
316401018719	putative GTP-binding protein YjiA; Provisional; Region: PRK11537
316401018720	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
316401018721	P-loop, Walker A motif; other site
316401018722	Base recognition motif; other site
316401018723	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
316401018724	PS00017 ATP/GTP-binding site motif A (P-loop).
316401018725	Uncharacterized small protein [Function unknown]; Region: COG2879
316401018726	carbon starvation protein A; Provisional; Region: PRK15015
316401018727	Carbon starvation protein CstA; Region: CstA; pfam02554
316401018728	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
316401018729	16 probable transmembrane helices predicted for ETEC4656 by TMHMM2.0 at aa 12-29, 34-56, 89-111, 121-140, 161-183, 193-215, 220-242, 257-279, 286-305, 325-347, 364-386, 486-505, 532-551, 566-588, 595-617 and 666-688
316401018730	Signal peptide predicted for ETEC4656 by SignalP 2.0 HMM (Signal peptide probability 0.659) with cleavage site probability 0.412 between residues 27 and 28
316401018731	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
316401018732	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
316401018733	dimer interface [polypeptide binding]; other site
316401018734	ligand binding site [chemical binding]; other site
316401018735	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
316401018736	dimerization interface [polypeptide binding]; other site
316401018737	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316401018738	dimer interface [polypeptide binding]; other site
316401018739	putative CheW interface [polypeptide binding]; other site
316401018740	Signal peptide predicted for ETEC4657 by SignalP 2.0 HMM (Signal peptide probability 0.992) with cleavage site probability 0.359 between residues 34 and 35
316401018741	2 probable transmembrane helices predicted for ETEC4657 by TMHMM2.0 at aa 7-29 and 192-214
316401018742	PS00538 Bacterial chemotaxis sensory transducers signature.
316401018743	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316401018744	D-galactonate transporter; Region: 2A0114; TIGR00893
316401018745	putative substrate translocation pore; other site
316401018746	11 probable transmembrane helices predicted for ETEC4658 by TMHMM2.0 at aa 39-56, 72-94, 109-131, 169-191, 195-217, 260-282, 297-319, 332-354, 358-380, 393-415 and 421-443
316401018747	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
316401018748	DNA-binding site [nucleotide binding]; DNA binding site
316401018749	Transcriptional regulators [Transcription]; Region: GntR; COG1802
316401018750	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
316401018751	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
316401018752	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
316401018753	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
316401018754	putative NAD(P) binding site [chemical binding]; other site
316401018755	catalytic Zn binding site [ion binding]; other site
316401018756	structural Zn binding site [ion binding]; other site
316401018757	PS00059 Zinc-containing alcohol dehydrogenases signature.
316401018758	phosphoglycerol transferase I; Provisional; Region: PRK03776
316401018759	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
316401018760	4 probable transmembrane helices predicted for ETEC4661 by TMHMM2.0 at aa 4-19, 26-48, 76-98 and 105-127
316401018761	Signal peptide predicted for ETEC4661 by SignalP 2.0 HMM (Signal peptide probability 0.747) with cleavage site probability 0.400 between residues 18 and 19
316401018762	hypothetical protein; Provisional; Region: PRK11667
316401018763	Signal peptide predicted for ETEC4662 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 25 and 26
316401018764	DNA replication protein DnaC; Validated; Region: PRK07952
316401018765	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316401018766	Walker A motif; other site
316401018767	ATP binding site [chemical binding]; other site
316401018768	Walker B motif; other site
316401018769	primosomal protein DnaI; Provisional; Region: PRK02854
316401018770	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
316401018771	3 probable transmembrane helices predicted for ETEC4665 by TMHMM2.0 at aa 15-33, 38-60 and 80-102
316401018772	Uncharacterized conserved protein [Function unknown]; Region: COG2966
316401018773	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
316401018774	3 probable transmembrane helices predicted for ETEC4666 by TMHMM2.0 at aa 167-189, 194-216 and 229-251
316401018775	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
316401018776	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
316401018777	DNA binding residues [nucleotide binding]
316401018778	dimerization interface [polypeptide binding]; other site
316401018779	DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475
316401018780	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
316401018781	DNA binding residues [nucleotide binding]
316401018782	dimerization interface [polypeptide binding]; other site
316401018783	ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647
316401018784	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
316401018785	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
316401018786	PS00294 Prenyl group binding site (CAAX box).
316401018787	Protein of unknown function (DUF1435); Region: DUF1435; pfam07256
316401018788	3 probable transmembrane helices predicted for ETEC4670 by TMHMM2.0 at aa 5-27, 32-49 and 56-75
316401018789	16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489
316401018790	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
316401018791	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316401018792	S-adenosylmethionine binding site [chemical binding]; other site
316401018793	PS00092 N-6 Adenine-specific DNA methylases signature.
316401018794	DNA polymerase III subunit psi; Validated; Region: PRK06856
316401018795	ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491
316401018796	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
316401018797	Coenzyme A binding pocket [chemical binding]; other site
316401018798	dUMP phosphatase; Provisional; Region: PRK09449
316401018799	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
316401018800	motif II; other site
316401018801	integrase; Provisional; Region: PRK09692
316401018802	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
316401018803	active site
316401018804	Int/Topo IB signature motif; other site
316401018805	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
316401018806	Protein of unknown function (DUF551); Region: DUF551; pfam04448
316401018807	Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896
316401018808	Uncharacterized conserved protein [Function unknown]; Region: COG5532
316401018809	1 probable transmembrane helix predicted for ETEC4681 by TMHMM2.0 at aa 10-32
316401018810	Signal peptide predicted for ETEC4681 by SignalP 2.0 HMM (Signal peptide probability 0.640) with cleavage site probability 0.592 between residues 24 and 25
316401018811	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
316401018812	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
316401018813	Catalytic site [active]
316401018814	Ash protein family; Region: Phage_ASH; pfam10554
316401018815	PS00070 Aldehyde dehydrogenases cysteine active site.
316401018816	Helix-turn-helix domain; Region: HTH_36; pfam13730
316401018817	PerC transcriptional activator; Region: PerC; pfam06069
316401018818	DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869
316401018819	PS00092 N-6 Adenine-specific DNA methylases signature.
316401018820	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
316401018821	Similar to C-terminus of Escherichia coli o1:k1/apec. putative uncharacterized protein. UniProt:A1AEI4 (EMBL:CP000468 (265 aa) fasta scores: E()=4.5e-79, 95.169% id in 207 aa
316401018822	IS2 repressor TnpA; Reviewed; Region: PRK09413
316401018823	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
316401018824	IS2 transposase TnpB; Reviewed; Region: PRK09409
316401018825	HTH-like domain; Region: HTH_21; pfam13276
316401018826	Integrase core domain; Region: rve; pfam00665
316401018827	Integrase core domain; Region: rve_3; pfam13683
316401018828	Protein of unknown function (DUF968); Region: DUF968; pfam06147
316401018829	Antitermination protein; Region: Antiterm; pfam03589
316401018830	DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684
316401018831	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
316401018832	Zn binding sites [ion binding]; other site
316401018833	Antitermination protein; Region: Antiterm; pfam03589
316401018834	PS00190 Cytochrome c family heme-binding site signature.
316401018835	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
316401018836	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316401018837	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
316401018838	DNA methylase; Region: N6_N4_Mtase; pfam01555
316401018839	PS00092 N-6 Adenine-specific DNA methylases signature.
316401018840	Lysis protein S; Region: Lysis_S; pfam04971
316401018841	2 probable transmembrane helices predicted for ETEC4699 by TMHMM2.0 at aa 28-47 and 57-79
316401018842	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
316401018843	catalytic residues [active]
316401018844	Bacteriophage lysis protein; Region: Phage_lysis; pfam03245
316401018845	Signal peptide predicted for ETEC4701 by SignalP 2.0 HMM (Signal peptide probability 0.729) with cleavage site probability 0.712 between residues 22 and 23
316401018846	1 probable transmembrane helix predicted for ETEC4701 by TMHMM2.0 at aa 4-23
316401018847	Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471
316401018848	Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525
316401018849	Bacteriophage capsid protein [General function prediction only]; Region: COG5511
316401018850	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
316401018851	Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022
316401018852	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
316401018853	tandem repeat interface [polypeptide binding]; other site
316401018854	oligomer interface [polypeptide binding]; other site
316401018855	active site residues [active]
316401018856	Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924
316401018857	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
316401018858	DNA packaging protein FI; Region: Packaging_FI; pfam14000
316401018859	Phage Head-Tail Attachment; Region: Phage_attach; pfam05354
316401018860	Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763
316401018861	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
316401018862	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
316401018863	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
316401018864	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
316401018865	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
316401018866	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
316401018867	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
316401018868	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
316401018869	Transposase; Region: HTH_Tnp_1; pfam01527
316401018870	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
316401018871	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
316401018872	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
316401018873	phage minor tail protein G; Region: phage_lambda_G; TIGR01674
316401018874	Minor tail protein T; Region: Phage_tail_T; pfam06223
316401018875	Phage-related minor tail protein [Function unknown]; Region: COG5281
316401018876	Prophage tail length tape measure protein; Region: TMP_2; pfam06791
316401018877	Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718
316401018878	Phage-related protein [Function unknown]; Region: COG4718
316401018879	Phage-related protein [Function unknown]; Region: gp18; COG4672
316401018880	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073
316401018881	MPN+ (JAMM) motif; other site
316401018882	Zinc-binding site [ion binding]; other site
316401018883	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
316401018884	NlpC/P60 family; Region: NLPC_P60; cl17555
316401018885	Phage-related protein, tail component [Function unknown]; Region: COG4723
316401018886	1 probable transmembrane helix predicted for ETEC4722 by TMHMM2.0 at aa 101-123
316401018887	Phage-related protein, tail component [Function unknown]; Region: COG4733
316401018888	Putative phage tail protein; Region: Phage-tail_3; pfam13550
316401018889	Domain of unknown function (DUF1983); Region: DUF1983; pfam09327
316401018890	Fibronectin type III protein; Region: DUF3672; pfam12421
316401018891	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
316401018892	Signal peptide predicted for ETEC4724 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 24 and 25
316401018893	PS00694 Enterobacterial virulence outer membrane protein signature 1.
316401018894	PS00695 Enterobacterial virulence outer membrane protein signature 2.
316401018895	Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400
316401018896	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
316401018897	Similar to C-terminus of Escherichia coli (strain k12). stfr UniProt:P76072 (EMBL:U00096 (1120 aa) fasta scores: E()=1.8e-114, 90.208% id in 337 aa
316401018898	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
316401018899	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
316401018900	trimer interface [polypeptide binding]; other site
316401018901	active site
316401018902	substrate binding site [chemical binding]; other site
316401018903	CoA binding site [chemical binding]; other site
316401018904	DinI-like family; Region: DinI; pfam06183
316401018905	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
316401018906	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
316401018907	G1 box; other site
316401018908	putative GEF interaction site [polypeptide binding]; other site
316401018909	GTP/Mg2+ binding site [chemical binding]; other site
316401018910	Switch I region; other site
316401018911	G2 box; other site
316401018912	G3 box; other site
316401018913	Switch II region; other site
316401018914	G4 box; other site
316401018915	G5 box; other site
316401018916	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
316401018917	PS00301 GTP-binding elongation factors signature.
316401018918	periplasmic protein; Provisional; Region: PRK10568
316401018919	BON domain; Region: BON; pfam04972
316401018920	Signal peptide predicted for ETEC4731 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 28 and 29
316401018921	Signal peptide predicted for ETEC4732 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.477 between residues 35 and 36
316401018922	2 probable transmembrane helices predicted for ETEC4732 by TMHMM2.0 at aa 7-29 and 33-55
316401018923	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
316401018924	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
316401018925	active site
316401018926	nucleophile elbow; other site
316401018927	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
316401018928	active site
316401018929	PS01137 Uncharacterized protein family UPF0006 signature 1.
316401018930	PS01090 Uncharacterized protein family UPF0006 signature 2.
316401018931	PS01091 Uncharacterized protein family UPF0006 signature 3.
316401018932	glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041
316401018933	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316401018934	FeS/SAM binding site; other site
316401018935	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401018936	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
316401018937	PS01087 Radical activating enzymes signature.
316401018938	PS00190 Cytochrome c family heme-binding site signature.
316401018939	hypothetical protein; Provisional; Region: PRK10977
316401018940	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
316401018941	intersubunit interface [polypeptide binding]; other site
316401018942	active site
316401018943	catalytic residue [active]
316401018944	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
316401018945	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
316401018946	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
316401018947	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
316401018948	PS00647 Thymidine and pyrimidine-nucleoside phosphorylases signature.
316401018949	phosphopentomutase; Provisional; Region: PRK05362
316401018950	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
316401018951	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
316401018952	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
316401018953	PS01232 Purine and other phosphorylases family 1 signature.
316401018954	PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature.
316401018955	lipoate-protein ligase A; Provisional; Region: lplA; PRK03822
316401018956	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
316401018957	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
316401018958	hypothetical protein; Provisional; Region: PRK11246
316401018959	1 probable transmembrane helix predicted for ETEC4742 by TMHMM2.0 at aa 13-32
316401018960	Signal peptide predicted for ETEC4742 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.855 between residues 30 and 31
316401018961	phosphoserine phosphatase; Provisional; Region: serB; PRK11133
316401018962	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
316401018963	motif II; other site
316401018964	DNA repair protein RadA; Region: sms; TIGR00416
316401018965	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
316401018966	Walker A motif/ATP binding site; other site
316401018967	ATP binding site [chemical binding]; other site
316401018968	Walker B motif; other site
316401018969	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
316401018970	PS00190 Cytochrome c family heme-binding site signature.
316401018971	PS00017 ATP/GTP-binding site motif A (P-loop).
316401018972	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
316401018973	non-specific DNA binding site [nucleotide binding]; other site
316401018974	salt bridge; other site
316401018975	bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099
316401018976	sequence-specific DNA binding site [nucleotide binding]; other site
316401018977	Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167
316401018978	active site
316401018979	(T/H)XGH motif; other site
316401018980	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
316401018981	PS00017 ATP/GTP-binding site motif A (P-loop).
316401018982	PS00687 Aldehyde dehydrogenases glutamic acid active site.
316401018983	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
316401018984	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316401018985	Walker A/P-loop; other site
316401018986	ATP binding site [chemical binding]; other site
316401018987	Q-loop/lid; other site
316401018988	ABC transporter signature motif; other site
316401018989	Walker B; other site
316401018990	D-loop; other site
316401018991	H-loop/switch region; other site
316401018992	ABC transporter; Region: ABC_tran_2; pfam12848
316401018993	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
316401018994	PS00017 ATP/GTP-binding site motif A (P-loop).
316401018995	PS00211 ABC transporters family signature.
316401018996	PS00017 ATP/GTP-binding site motif A (P-loop).
316401018997	lytic murein transglycosylase; Provisional; Region: PRK11619
316401018998	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
316401018999	N-acetyl-D-glucosamine binding site [chemical binding]; other site
316401019000	catalytic residue [active]
316401019001	Signal peptide predicted for ETEC4747 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.994 between residues 27 and 28
316401019002	PS00922 Prokaryotic transglycosylases signature.
316401019003	Trp operon repressor; Provisional; Region: PRK01381
316401019004	inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074
316401019005	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
316401019006	catalytic core [active]
316401019007	PS00175 Phosphoglycerate mutase family phosphohistidine signature.
316401019008	1 probable transmembrane helix predicted for ETEC4750 by TMHMM2.0 at aa 146-168
316401019009	right oriC-binding transcriptional activator; Provisional; Region: PRK15121
316401019010	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316401019011	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
316401019012	PS00041 Bacterial regulatory proteins, araC family signature.
316401019013	hypothetical protein; Provisional; Region: PRK10756
316401019014	CreA protein; Region: CreA; pfam05981
316401019015	Signal peptide predicted for ETEC4752 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 21 and 22
316401019016	DNA-binding response regulator CreB; Provisional; Region: PRK11083
316401019017	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316401019018	active site
316401019019	phosphorylation site [posttranslational modification]
316401019020	intermolecular recognition site; other site
316401019021	dimerization interface [polypeptide binding]; other site
316401019022	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
316401019023	DNA binding site [nucleotide binding]
316401019024	sensory histidine kinase CreC; Provisional; Region: PRK11100
316401019025	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
316401019026	dimerization interface [polypeptide binding]; other site
316401019027	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316401019028	dimer interface [polypeptide binding]; other site
316401019029	phosphorylation site [posttranslational modification]
316401019030	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316401019031	ATP binding site [chemical binding]; other site
316401019032	Mg2+ binding site [ion binding]; other site
316401019033	G-X-G motif; other site
316401019034	Signal peptide predicted for ETEC4754 by SignalP 2.0 HMM (Signal peptide probability 0.879) with cleavage site probability 0.309 between residues 24 and 25
316401019035	2 probable transmembrane helices predicted for ETEC4754 by TMHMM2.0 at aa 5-27 and 184-206
316401019036	Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452
316401019037	5 probable transmembrane helices predicted for ETEC4755 by TMHMM2.0 at aa 10-32, 298-317, 321-343, 350-372 and 402-424
316401019038	two-component response regulator; Provisional; Region: PRK11173
316401019039	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316401019040	active site
316401019041	phosphorylation site [posttranslational modification]
316401019042	intermolecular recognition site; other site
316401019043	dimerization interface [polypeptide binding]; other site
316401019044	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
316401019045	DNA binding site [nucleotide binding]
316401019046	putative RNA methyltransferase; Provisional; Region: PRK10433
316401019047	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
316401019048	HMMPfam hit to PF03432, Relaxase/Mobilisation nuclease domain, score 2.2e-08
316401019049	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
316401019050	HMMPfam hit to PF05713, Bacterial mobilisation protein (MobC), score 4.7e-20
316401019051	Rop protein; Region: Rop; pfam01815
316401019052	HMMPfam hit to PF01815, Rop protein, score 2.4e-45
316401019053	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
316401019054	HMMPfam hit to PF02604, PhdYeFM, score 1e-07
316401019055	HMMTigr hit to TIGR01552, phd_fam: prevent-host-death family protein, score 0.016
316401019057	replication protein; Provisional; Region: PRK13750
316401019058	HMMPfam hit to PF02387, IncFII_repA, score 1.7e-08
316401019059	leader peptide RepL; Provisional; Region: PRK13716
316401019060	HMMPfam hit to PF08048, RepA1_leader, score 1.9e-08
316401019061	replication protein; Provisional; Region: PRK13702
316401019062	superfamily hit to SSF47598, Met repressor-like, score 0.0003
316401019063	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
316401019064	superfamily hit to SSF52980, Restriction endonuclease-like, score 2e-07
316401019065	Signal peptide predicted for p666.0070 by SignalP 2.0 HMM (Signal peptide probability 0.870) with cleavage site probability 0.408 between residues 27 and 28
316401019066	Haemolysin expression modulating protein; Region: HHA; pfam05321
316401019067	superfamily hit to SSF68989, Hemolysin expression modulating protein HHA, score 4.7e-21
316401019068	HMMPfam hit to PF05321, HHA, score 1.8e-30
316401019069	Staphylococcal nuclease homologues; Region: SNc; smart00318
316401019070	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
316401019071	Catalytic site; other site
316401019072	superfamily hit to SSF50199, Staphylococcal nuclease, score 1e-36
316401019073	HMMPfam hit to PF00565, SNase, score 1.3e-59
316401019074	conjugal transfer fertility inhibition protein FinO; Provisional; Region: PRK13754
316401019075	Fertility inhibition protein N terminal; Region: FinO_N; pfam12602
316401019076	FinO bacterial conjugation repressor domain;  the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cd00236
316401019077	putative RNA binding sites [nucleotide binding]; other site
316401019078	HMMPfam hit to PF05286, FINO, score 5.9e-122
316401019079	superfamily hit to SSF48657, Repressor of bacterial conjugation FinO, score 2.1e-59
316401019080	conjugal transfer pilus acetylation protein TraX; Provisional; Region: PRK13706
316401019081	HMMTigr hit to TIGR02755, TraX_Ftype: type-F conjugative transfer sy, score 5e-172
316401019082	5 probable transmembrane helices predicted for traX by TMHMM2.0 at aa 102-124, 144-166, 179-196, 200-219 and 226-247
316401019083	HMMPfam hit to PF05857, TraX, score 1.6e-83
316401019084	conjugal transfer nickase/helicase TraI; Provisional; Region: PRK13709
316401019085	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
316401019086	AAA domain; Region: AAA_30; pfam13604
316401019087	DNA helicase TraI; Region: TraI; pfam07057
316401019088	HMMTigr hit to TIGR02760, TraI_TIGR: conjugative transfer relaxase p, score 0
316401019089	HMMPfam hit to PF07057, TraI, score 4.9e-98
316401019090	superfamily hit to SSF52540, P-loop containing nucleoside triphosphate hydrolases, score 5.9e-20
316401019091	superfamily hit to SSF52540, P-loop containing nucleoside triphosphate hydrolases, score 0.00011
316401019092	HMMPfam hit to PF08751, TrwC, score 6.1e-139
316401019093	HMMTigr hit to TIGR02686, relax_trwC: conjugative relaxase domain, score 7.5e-180
316401019094	conjugal transfer protein TraD; Provisional; Region: PRK13700
316401019095	F sex factor protein N terminal; Region: TraD_N; pfam12615
316401019096	Bacterial conjugation protein TrwB,  ATP binding domain. TrwB is a homohexamer encoded by conjugative plasmids in Gram-negative bacteria. TrwB also has an all alpha domain which has been hypothesized to be responsible for DNA binding. TrwB is a component...; Region: TrwB; cd01127
316401019097	multimer interface [polypeptide binding]; other site
316401019098	Walker A motif; other site
316401019099	ATP binding site [chemical binding]; other site
316401019100	Walker B motif; other site
316401019101	HMMTigr hit to TIGR02759, TraD_Ftype: type IV conjugative transfer s, score 0
316401019102	superfamily hit to SSF52540, P-loop containing nucleoside triphosphate hydrolases, score 1.5e-22
316401019103	HMMPfam hit to PF02534, TraG, score 0.00062
316401019104	2 probable transmembrane helices predicted for traD by TMHMM2.0 at aa 25-47 and 108-130
316401019106	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
316401019107	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
316401019108	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
316401019109	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
316401019110	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
316401019111	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
316401019112	HMMPfam hit to PF03050, Transposase_25, score 4.1e-129
316401019113	superfamily hit to SSF54197, HIT-like, score 2.4e-09
316401019114	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
316401019115	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
316401019116	HMMPfam hit to PF05717, Transposase_34, score 1.1e-69
316401019117	Transposase; Region: HTH_Tnp_1; pfam01527
316401019118	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
316401019119	HMMPfam hit to PF01527, Transposase_8, score 2e-22
316401019120	superfamily hit to SSF46689, Homeodomain-like, score 4.2e-06
316401019121	superfamily hit to SSF46689, Homeodomain-like, score 0.013
316401019122	Transposase; Region: HTH_Tnp_1; pfam01527
316401019123	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
316401019124	superfamily hit to SSF46689, Homeodomain-like, score 2e-05
316401019125	HMMPfam hit to PF01527, Transposase_8, score 9.7e-26
316401019126	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
316401019127	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
316401019128	HMMPfam hit to PF05717, Transposase_34, score 9.6e-69
316401019129	Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044
316401019130	homodimer interface [polypeptide binding]; other site
316401019131	putative GKAP docking site [polypeptide binding]; other site
316401019132	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
316401019133	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
316401019134	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
316401019135	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
316401019136	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
316401019137	superfamily hit to SSF46579, Prefoldin, score 5.4e-05
316401019138	superfamily hit to SSF54197, HIT-like, score 0.00067
316401019139	HMMPfam hit to PF03050, Transposase_25, score 3e-131
316401019140	superfamily hit to SSF50249, Nucleic acid-binding proteins, score 1.2e-05
316401019142	conjugal transfer protein TraR; Provisional; Region: PRK13715
316401019143	HMMPfam hit to PF01258, zf-dskA_traR, score 3.9e-38
316401019144	HMMTigr hit to TIGR02419, C4_traR_proteo: phage/conjugal plasmid, score 5.8e-30
316401019145	superfamily hit to SSF57716, Glucocorticoid receptor-like (DNA-binding domain), score 0.0022
316401019146	conjugal transfer protein TraV; Provisional; Region: PRK13733
316401019147	Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676
316401019148	HMMTigr hit to TIGR02747, TraV: type IV conjugative transfer system pr, score 1.8e-61
316401019149	superfamily hit to SSF56601, beta-lactamase/transpeptidase-like, score 0.0052
316401019150	Signal peptide predicted for traV by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.430 between residues 22 and 23
316401019151	conjugal transfer protein TrbG; Provisional; Region: PRK13744
316401019152	conjugal transfer protein TrbD; Provisional; Region: PRK13724
316401019153	conjugal transfer protein TraP; Provisional; Region: PRK13739
316401019154	HMMPfam hit to PF07296, TraP, score 3.4e-132
316401019155	2 probable transmembrane helices predicted for traP by TMHMM2.0 at aa 19-41 and 108-130
316401019156	conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729
316401019157	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
316401019158	HMMPfam hit to PF06447, TraB_pillus, score 2.4e-214
316401019159	Signal peptide predicted for traB by SignalP 2.0 HMM (Signal peptide probability 0.792) with cleavage site probability 0.407 between residues 28 and 29
316401019160	conjugal transfer protein TraK; Provisional; Region: PRK13736
316401019161	TraK protein; Region: TraK; pfam06586
316401019162	HMMPfam hit to PF06586, TraK, score 1.2e-185
316401019163	HMMTigr hit to TIGR02756, TraK_Ftype: type-F conjugative transfer sy, score 4.1e-99
316401019164	Signal peptide predicted for traK by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.826 between residues 21 and 22
316401019165	conjugal transfer pilus assembly protein TraE; Provisional; Region: PRK13726
316401019166	HMMPfam hit to PF05309, TraE, score 1.1e-133
316401019167	HMMTigr hit to TIGR02761, TraE_TIGR: type IV conjugative transfer sys, score 1.1e-86
316401019168	1 probable transmembrane helix predicted for traE by TMHMM2.0 at aa 10-32
316401019169	conjugal transfer pilus assembly protein TraL; Provisional; Region: PRK13707
316401019170	HMMPfam hit to PF07178, TraL, score 6.7e-35
316401019171	HMMTigr hit to TIGR02762, TraL_TIGR: type IV conjugative transfer sys, score 5.5e-25
316401019172	1 probable transmembrane helix predicted for traL by TMHMM2.0 at aa 38-60
316401019173	conjugal transfer pilin subunit TraA; Provisional; Region: PRK13734
316401019174	HMMTigr hit to TIGR02758, TraA_TIGR: type IV conjugative transfer sys, score 1.2e-50
316401019175	HMMPfam hit to PF05513, TraA, score 1.4e-76
316401019176	3 probable transmembrane helices predicted for traA by TMHMM2.0 at aa 31-53, 77-94 and 101-120
316401019177	Signal peptide predicted for traA by SignalP 2.0 HMM (Signal peptide probability 0.958) with cleavage site probability 0.686 between residues 51 and 52
316401019178	conjugal transfer protein TraY; Provisional; Region: PRK13740
316401019179	TraY domain; Region: TraY; cl17675
316401019180	HMMPfam hit to PF05509, TraY, score 5e-96
316401019181	superfamily hit to SSF47598, Met repressor-like, score 0.0054
316401019182	conjugal transfer transcriptional regulator TraJ; Provisional; Region: PRK13719
316401019183	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
316401019184	superfamily hit to SSF46894, C-terminal effector domain of the bipartite response regulators, score 4.4e-08
316401019185	superfamily hit to SSF55785, PYP-like sensor domain (PAS domain), score 0.016
316401019186	TraM protein; Region: Tra_M; pfam05261
316401019187	HMMPfam hit to PF05261, Tra_M, score 1.5e-97
316401019188	superfamily hit to SSF47729, IHF-like DNA-binding proteins, score 6.1e-17
316401019189	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
316401019190	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
316401019191	N-acetyl-D-glucosamine binding site [chemical binding]; other site
316401019192	catalytic residue [active]
316401019193	Signal peptide predicted for X by SignalP 2.0 HMM (Signal peptide probability 0.978) with cleavage site probability 0.976 between residues 19 and 20
316401019194	superfamily hit to SSF53955, Lysozyme-like, score 1.4e-25
316401019195	HMMPfam hit to PF01464, SLT, score 1.1e-41
316401019196	Domain of unknown function (DUF932); Region: DUF932; pfam06067
316401019197	HMMPfam hit to PF06067, DUF932, score 7.3e-226
316401019198	excinuclease ABC subunit B; Provisional; Region: PRK05298
316401019199	small toxic polypeptide; Provisional; Region: PRK09738
316401019200	modulator of post-segregation killing protein; Provisional; Region: PRK13720
316401019201	HMMPfam hit to PF01848, HOK_GEF, score 6.6e-22
316401019202	1 probable transmembrane helix predicted for hok by TMHMM2.0 at aa 4-26
316401019203	plasmid SOS inhibition protein A; Provisional; Region: PRK13704
316401019204	HMMPfam hit to PF06952, PsiA, score 4.1e-175
316401019205	plasmid SOS inhibition protein B; Provisional; Region: psiB; PRK13701
316401019206	HMMPfam hit to PF06290, PsiB, score 8.2e-126
316401019208	HMMTigr hit to TIGR00180, parB_part: ParB-like partition proteins, score 3.8e-16
316401019209	superfamily hit to SSF46689, Homeodomain-like, score 0.0089
316401019210	HMMPfam hit to PF02195, ParBc, score 3.5e-27
316401019211	Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006
316401019212	HMMPfam hit to PF06006, DUF905, score 6e-46
316401019213	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
316401019214	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
316401019215	dimer interface [polypeptide binding]; other site
316401019216	ssDNA binding site [nucleotide binding]; other site
316401019217	tetramer (dimer of dimers) interface [polypeptide binding]; other site
316401019218	superfamily hit to SSF50249, Nucleic acid-binding proteins, score 6.9e-47
316401019219	HMMTigr hit to TIGR00621, ssb: single-strand binding protein, score 1e-62
316401019220	HMMPanther hit to PTHR10302, SINGLE-STRANDED DNA-BINDING PROTEIN, SSB, score 6.5e-51
316401019221	HMMPfam hit to PF00436, SSB, score 1.6e-31
316401019222	putative group II intron
316401019223	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
316401019224	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
316401019225	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
316401019226	putative active site [active]
316401019227	putative NTP binding site [chemical binding]; other site
316401019228	putative nucleic acid binding site [nucleotide binding]; other site
316401019229	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
316401019230	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
316401019231	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
316401019232	active site
316401019233	superfamily hit to SSF56672, DNA/RNA polymerases, score 2.8e-29
316401019234	HMMPfam hit to PF00078, RVT_1, score 6e-56
316401019235	HMMPanther hit to PTHR19446, REVERSE TRANSCRIPTASES, score 2.8e-08
316401019236	HMMPfam hit to PF08388, GIIM, score 2.1e-31
316401019237	superfamily hit to SSF54060, His-Me finger endonucleases, score 2.7e-16
316401019238	HMMPfam hit to PF01844, HNH, score 2.2e-08
316401019239	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316401019240	S-adenosylmethionine binding site [chemical binding]; other site
316401019241	superfamily hit to SSF53335, S-adenosyl-L-methionine-dependent methyltransferases, score 2e-37
316401019242	Domain of unknown function (DUF3560); Region: DUF3560; pfam12083
316401019243	Protein of unknown function (DUF1380); Region: DUF1380; pfam07128
316401019244	HMMPfam hit to PF07128, DUF1380, score 9.5e-107
316401019245	putative methylase; Provisional; Region: PRK13699
316401019246	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
316401019247	superfamily hit to SSF53335, S-adenosyl-L-methionine-dependent methyltransferases, score 6e-35
316401019248	HMMPfam hit to PF01555, N6_N4_Mtase, score 4.7e-47
316401019249	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
316401019250	Mg binding site [ion binding]; other site
316401019251	nucleotide binding site [chemical binding]; other site
316401019252	putative protofilament interface [polypeptide binding]; other site
316401019253	HMMPfam hit to PF06406, StbA, score 6.3e-236
316401019254	superfamily hit to SSF53067, Actin-like ATPase domain, score 2.1e-53
316401019255	superfamily hit to SSF53067, Actin-like ATPase domain, score 2.8e-16
316401019256	Plasmid stability protein; Region: Plasmid_stab_B; pfam10784
316401019258	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
316401019259	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
316401019260	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
316401019261	IS1 transposase; Region: DDE_Tnp_IS1; pfam03400
316401019262	HMMPfam hit to PF03811, Ins_element1, score 7.7e-68
316401019263	superfamily hit to SSF46689, Homeodomain-like, score 0.00031
316401019264	HMMPfam hit to PF03400, Transposase_27, score 3.1e-112
316401019266	superfamily hit to SSF47413, lambda repressor-like DNA-binding domains, score 3.1e-11
316401019267	HMMPfam hit to PF01381, HTH_3, score 1e-12
316401019268	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
316401019269	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
316401019270	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
316401019271	IS1 transposase; Region: DDE_Tnp_IS1; pfam03400
316401019272	HMMPfam hit to PF03400, Transposase_27, score 6.5e-113
316401019273	HMMPfam hit to PF03811, Ins_element1, score 5.1e-68
316401019274	superfamily hit to SSF46689, Homeodomain-like, score 0.00017
316401019275	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
316401019276	Transposase; Region: HTH_Tnp_1; pfam01527
316401019277	HMMPfam hit to PF01527, Transposase_8, score 1.4e-15
316401019278	putative transposase OrfB; Reviewed; Region: PHA02517
316401019279	Integrase core domain; Region: rve; pfam00665
316401019280	Integrase core domain; Region: rve_3; pfam13683
316401019281	superfamily hit to SSF53098, Ribonuclease H-like, score 9.6e-38
316401019282	HMMPfam hit to PF00665, rve, score 6.5e-44
316401019283	Heat-labile enterotoxin beta chain; Region: Enterotoxin_b; pfam01376
316401019284	superfamily hit to SSF50203, Bacterial enterotoxins, score 6.8e-64
316401019285	HMMPfam hit to PF01376, Enterotoxin_b, score 3.9e-86
316401019286	Signal peptide predicted for eltB by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.996 between residues 21 and 22
316401019287	Heat-labile enterotoxin alpha chain; Region: Enterotoxin_a; pfam01375
316401019288	HMMPfam hit to PF01375, Enterotoxin_a, score 4.9e-220
316401019289	superfamily hit to SSF56399, ADP-ribosylation, score 3.1e-104
316401019290	Signal peptide predicted for eltA by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.580 between residues 18 and 19
316401019292	HMMPfam hit to PF04986, Transposase_32, score 2.2e-09
316401019294	superfamily hit to SSF53098, Ribonuclease H-like, score 2.2e-19
316401019295	HMMPfam hit to PF00665, rve, score 1.2e-24
316401019297	superfamily hit to SSF54197, HIT-like, score 1.6e-05
316401019298	Transposase; Region: HTH_Tnp_1; pfam01527
316401019299	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
316401019300	superfamily hit to SSF46689, Homeodomain-like, score 0.013
316401019301	HMMPfam hit to PF01527, Transposase_8, score 2e-22
316401019302	superfamily hit to SSF46689, Homeodomain-like, score 4.2e-06
316401019303	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
316401019304	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
316401019305	HMMPfam hit to PF05717, Transposase_34, score 1.1e-69
316401019306	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
316401019307	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
316401019308	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
316401019309	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
316401019310	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
316401019311	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
316401019312	superfamily hit to SSF54197, HIT-like, score 2.4e-09
316401019313	HMMPfam hit to PF03050, Transposase_25, score 4.1e-129
316401019314	Heat-stable enterotoxin ST; Region: Enterotoxin_ST; pfam02048
316401019315	HMMPfam hit to PF02048, Enterotoxin_HS, score 1.5e-31
316401019316	Signal peptide predicted for sta1 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.898 between residues 19 and 20
316401019317	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
316401019318	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
316401019319	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
316401019320	IS1 transposase; Region: DDE_Tnp_IS1; pfam03400
316401019321	HMMPfam hit to PF03400, Transposase_27, score 6.8e-111
316401019322	HMMPfam hit to PF03811, Ins_element1, score 7.7e-68
316401019323	superfamily hit to SSF46689, Homeodomain-like, score 0.00031
316401019325	HMMPfam hit to PF04986, Transposase_32, score 2.2e-09
316401019326	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
316401019327	superfamily hit to SSF47413, lambda repressor-like DNA-binding domains, score 0.0037
316401019329	HMMPfam hit to PF04986, Transposase_32, score 8.4e-18
316401019330	superfamily hit to SSF50615, N-terminal domain of alpha and beta subunits of F1 ATP synthase, score 0.00016
316401019331	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
316401019332	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316401019333	dimer interface [polypeptide binding]; other site
316401019334	phosphorylation site [posttranslational modification]
316401019335	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316401019336	ATP binding site [chemical binding]; other site
316401019337	Mg2+ binding site [ion binding]; other site
316401019338	G-X-G motif; other site
316401019339	HMMPanther hit to PTHR23283:SF34, TWO COMPONENT SENSOR HISTIDINE KINASE (PHOR), score 7.1e-56; HMMPanther hit to PTHR23283, SENSOR HISTIDINE KINASE-RELATED, score 7.1e-56
316401019340	superfamily hit to SSF55874, ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase, score 7.1e-40
316401019341	HMMPfam hit to PF02518, HATPase_c, score 9.2e-28
316401019342	HMMPfam hit to PF00512, HisKA, score 1.1e-19
316401019343	superfamily hit to SSF47384, Homodimeric domain of signal transducing histidine kinase, score 1.7e-14
316401019344	HMMPfam hit to PF00672, HAMP, score 0.0041
316401019345	2 probable transmembrane helices predicted for p666.0810 by TMHMM2.0 at aa 13-32 and 181-203
316401019346	Signal peptide predicted for p666.0810 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.800 between residues 26 and 27
316401019347	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
316401019348	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316401019349	active site
316401019350	phosphorylation site [posttranslational modification]
316401019351	intermolecular recognition site; other site
316401019352	dimerization interface [polypeptide binding]; other site
316401019353	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
316401019354	DNA binding site [nucleotide binding]
316401019355	HMMPfam hit to PF00486, Trans_reg_C, score 4.8e-23
316401019356	superfamily hit to SSF52172, CheY-like, score 1.1e-44
316401019357	HMMPanther hit to PTHR23283:SF21, TWO-COMPONENT SYSTEM SENSOR HISTIDINE KINASE/RESPONSE REGULATOR (INTESTINAL BACTERIA - BACTEROIDES THETAIOTAOMICRON), score 5e-29; HMMPanther hit to PTHR23283, SENSOR HISTIDINE KINASE-RELATED, score 5e-29
316401019358	HMMPfam hit to PF00072, Response_reg, score 5.8e-39
316401019359	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
316401019360	superfamily hit to SSF81342, Transmembrane di-heme cytochromes, score 2.5e-39
316401019361	4 probable transmembrane helices predicted for p666.0830 by TMHMM2.0 at aa 13-35, 59-81, 126-145 and 165-187
316401019362	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
316401019363	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
316401019364	Moco binding site; other site
316401019365	metal coordination site [ion binding]; other site
316401019366	HMMPanther hit to PTHR19372, SULFITE REDUCTASE, score 6.7e-06
316401019367	superfamily hit to SSF56524, Sulfite oxidase, middle catalytic domain, score 2e-56
316401019368	HMMPfam hit to PF00174, Oxidored_molyb, score 1.3e-65
316401019369	Fimbrial protein; Region: Fimbrial; cl01416
316401019370	Signal peptide predicted for p666.0850 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 21 and 22
316401019372	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316401019373	AAA domain; Region: AAA_21; pfam13304
316401019374	Walker A/P-loop; other site
316401019375	ATP binding site [chemical binding]; other site
316401019376	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316401019377	Q-loop/lid; other site
316401019378	ABC transporter signature motif; other site
316401019379	Walker B; other site
316401019380	D-loop; other site
316401019381	H-loop/switch region; other site
316401019382	superfamily hit to SSF52540, P-loop containing nucleoside triphosphate hydrolases, score 0.0001
316401019383	superfamily hit to SSF52540, P-loop containing nucleoside triphosphate hydrolases, score 1.1e-17
316401019384	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
316401019385	HMMTigr hit to TIGR02385, RelE_StbE: addiction module toxin, RelE/Stb, score 4.2e-09
316401019386	HMMPfam hit to PF05016, Plasmid_stabil, score 4.1e-16
316401019387	1 probable transmembrane helix predicted for relE by TMHMM2.0 at aa 57-79
316401019388	Protein of unknown function (DUF1044); Region: DUF1044; cl01955
316401019389	1 probable transmembrane helix predicted for p58.0001 by TMHMM2.0 at aa 62-84
316401019390	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
316401019391	HMMPfam hit to PF03432, Relaxase/Mobilisation nuclease domain, score 9.7e-10
316401019392	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
316401019393	HMMPfam hit to PF05713, Bacterial mobilisation protein (MobC), score 2.8e-12
316401019394	Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes.  All members...; Region: cytidine_deaminase-like; cl00269
316401019395	Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes.  All members...; Region: cytidine_deaminase-like; cl00269
316401019396	active site
316401019397	Zn binding site [ion binding]; other site
316401019398	superfamily hit to SSF52540, P-loop containing nucleoside triphosphate hydrolases, score 0.00087
316401019399	superfamily hit to SSF53927, Cytidine deaminase-like, score 5.8e-22
316401019400	HMMPfam hit to PF00383, Cytidine and deoxycytidylate deaminas, score 7e-17
316401019401	ScanRegExp hit to PS00903, CYT_DCMP_DEAMINASES, score NA
316401019402	Replicase family; Region: Replicase; pfam03090
316401019403	Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708
316401019404	HMMPfam hit to PF03090, Replicase family, score 1.6e-116
316401019405	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
316401019406	non-specific DNA binding site [nucleotide binding]; other site
316401019407	salt bridge; other site
316401019408	sequence-specific DNA binding site [nucleotide binding]; other site
316401019409	superfamily hit to SSF47413, lambda repressor-like DNA-binding domains, score 6.5e-09
316401019410	HMMPfam hit to PF01381, Helix-turn-helix, score 1.1e-05
316401019411	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
316401019412	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
316401019413	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
316401019414	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
316401019415	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
316401019416	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
316401019417	HMMPfam hit to PF03050, Transposase_25, score 2.8e-19
316401019418	Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395
316401019419	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343
316401019420	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
316401019421	Autotransporter beta-domain; Region: Autotransporter; pfam03797
316401019422	HMMTigr hit to TIGR01414, autotrans_barl: outer membrane autotra, score 6.9e-69
316401019423	superfamily hit to SSF56935, Porins, score 2.1e-07
316401019424	HMMPfam hit to PF03797, Autotransporter, score 2.7e-38
316401019425	HMMPfam hit to PF03212, Pertactin, score 0.0029
316401019426	superfamily hit to SSF51126, Pectin lyase-like, score 1.8e-71
316401019427	HMMPfam hit to PF02395, Peptidase_S6, score 0
316401019428	superfamily hit to SSF50494, Trypsin-like serine proteases, score 1.7e-11
316401019429	Signal peptide predicted for p948.0020 by SignalP 2.0 HMM (Signal peptide probability 0.974) with cleavage site probability 0.966 between residues 56 and 57
316401019431	HMMPfam hit to PF01526, Transposase_7, score 1.7e-57
316401019432	putative transposase OrfB; Reviewed; Region: PHA02517
316401019433	HTH-like domain; Region: HTH_21; pfam13276
316401019434	Integrase core domain; Region: rve; pfam00665
316401019435	Integrase core domain; Region: rve_3; cl15866
316401019436	HMMPfam hit to PF00665, rve, score 2.8e-42
316401019437	superfamily hit to SSF53098, Ribonuclease H-like, score 3e-39
316401019438	1 probable transmembrane helix predicted for p948.0040 by TMHMM2.0 at aa 141-163
316401019439	superfamily hit to SSF46785, 'Winged helix' DNA-binding domain, score 4.2e-08
316401019440	Transposase; Region: HTH_Tnp_1; cl17663
316401019441	superfamily hit to SSF46689, Homeodomain-like, score 0.0072
316401019442	HMMPfam hit to PF01527, Transposase_8, score 7.9e-13
316401019443	IS element transposase (pseudogene)
316401019445	superfamily hit to SSF53098, Ribonuclease H-like, score 3.3e-05
316401019446	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
316401019447	Protein of unknown function (DUF433); Region: DUF433; cl01030
316401019448	MULE transposase domain; Region: MULE; pfam10551
316401019449	HMMPfam hit to PF00872, Transposase_mut, score 1.2e-139
316401019450	superfamily hit to SSF47364, Domain of the SRP/SRP receptor G-proteins, score 0.00083
316401019451	Protein of unknown function (DUF2919); Region: DUF2919; pfam11143
316401019452	4 probable transmembrane helices predicted for p948.0090 by TMHMM2.0 at aa 20-37, 52-74, 81-103 and 118-135
316401019453	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK13103
316401019454	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
316401019455	haemagglutination activity domain; Region: Haemagg_act; smart00912
316401019456	HMMPfam hit to PF05594, Fil_haemagg, score 1.6
316401019457	HMMPfam hit to PF05594, Fil_haemagg, score 1.6
316401019458	HMMPfam hit to PF05594, Fil_haemagg, score 1.6
316401019459	HMMPfam hit to PF05860, Haemagg_act, score 6.6e-34
316401019460	HMMTigr hit to TIGR01901, adhes_NPXG: filamentous haemagglutinin fam, score 1.9e-32
316401019461	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
316401019462	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
316401019463	HMMPfam hit to PF08479, POTRA_2, score 3.5e-17
316401019464	Signal peptide predicted for p948.0120 by SignalP 2.0 HMM (Signal peptide probability 0.900) with cleavage site probability 0.899 between residues 46 and 47
316401019467	putative transposase OrfB; Reviewed; Region: PHA02517
316401019468	HTH-like domain; Region: HTH_21; pfam13276
316401019469	Integrase core domain; Region: rve; pfam00665
316401019470	Integrase core domain; Region: rve_3; cl15866
316401019471	HMMPfam hit to PF00665, rve, score 2.8e-42
316401019472	superfamily hit to SSF53098, Ribonuclease H-like, score 3e-39
316401019473	1 probable transmembrane helix predicted for p948.0160 by TMHMM2.0 at aa 141-163
316401019474	superfamily hit to SSF46785, 'Winged helix' DNA-binding domain, score 4.2e-08
316401019475	Transposase; Region: HTH_Tnp_1; cl17663
316401019476	superfamily hit to SSF46689, Homeodomain-like, score 0.0072
316401019477	HMMPfam hit to PF01527, Transposase_8, score 7.9e-13
316401019479	HMMPfam hit to PF01527, Transposase_8, score 1.7e-12
316401019480	superfamily hit to SSF46689, Homeodomain-like, score 2.7e-05
316401019481	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
316401019482	HMMPfam hit to PF05016, Plasmid_stabil, score 8.5e-11
316401019483	RelB antitoxin; Region: RelB; cl01171
316401019484	superfamily hit to SSF47598, Met repressor-like, score 4.6e-06
316401019485	replication protein; Provisional; Region: PRK13750
316401019486	HMMPfam hit to PF02387, IncFII_repA, score 3e-08
316401019487	leader peptide RepL; Provisional; Region: PRK13716
316401019488	HMMPfam hit to PF08048, RepA1_leader, score 1.9e-08
316401019489	replication protein; Provisional; Region: PRK13702
316401019490	superfamily hit to SSF47598, Met repressor-like, score 8e-05
316401019491	Transposase; Region: HTH_Tnp_1; cl17663
316401019492	superfamily hit to SSF46689, Homeodomain-like, score 0.0072
316401019493	HMMPfam hit to PF01527, Transposase_8, score 7.9e-13
316401019494	putative transposase OrfB; Reviewed; Region: PHA02517
316401019495	HTH-like domain; Region: HTH_21; pfam13276
316401019496	Integrase core domain; Region: rve; pfam00665
316401019497	Integrase core domain; Region: rve_3; cl15866
316401019498	superfamily hit to SSF46785, 'Winged helix' DNA-binding domain, score 4.2e-08
316401019499	superfamily hit to SSF53098, Ribonuclease H-like, score 4.2e-40
316401019500	HMMPfam hit to PF00665, rve, score 6.4e-44
316401019501	plasmid-partitioning protein SopA; Provisional; Region: PRK13705
316401019502	MerR family regulatory protein; Region: MerR; pfam00376
316401019503	DNA binding residues [nucleotide binding]
316401019504	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
316401019505	P-loop; other site
316401019506	Magnesium ion binding site [ion binding]; other site
316401019507	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
316401019508	Magnesium ion binding site [ion binding]; other site
316401019509	superfamily hit to SSF46955, Putative DNA-binding domain, score 8.3e-07
316401019510	HMMPfam hit to PF00376, MerR, score 0.0064
316401019511	superfamily hit to SSF52540, P-loop containing nucleoside triphosphate hydrolases, score 6.5e-31
316401019512	HMMPfam hit to PF01656, CbiA, score 2.6e-37
316401019513	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
316401019514	ParB-like nuclease domain; Region: ParB; smart00470
316401019515	HMMTigr hit to TIGR00180, parB_part: ParB-like partition proteins, score 1e-43
316401019516	HMMPfam hit to PF02195, ParBc, score 2.1e-13
316401019517	Protein of unknown function (DUF1281); Region: DUF1281; pfam06924
316401019518	HMMPfam hit to PF06924, DUF1281, score 7.5e-135
316401019519	putative transposase OrfB; Reviewed; Region: PHA02517
316401019520	HTH-like domain; Region: HTH_21; pfam13276
316401019521	Integrase core domain; Region: rve; pfam00665
316401019522	Integrase core domain; Region: rve_3; pfam13683
316401019523	HMMPfam hit to PF00665, rve, score 1.4e-44
316401019524	superfamily hit to SSF53098, Ribonuclease H-like, score 2e-40
316401019525	superfamily hit to SSF46785, 'Winged helix' DNA-binding domain, score 4.2e-08
316401019526	Transposase; Region: HTH_Tnp_1; cl17663
316401019527	superfamily hit to SSF46689, Homeodomain-like, score 0.0072
316401019528	HMMPfam hit to PF01527, Transposase_8, score 7.9e-13
316401019530	HMMPfam hit to PF01695, IstB, score 8.4e-39
316401019531	HMMPfam hit to PF00665, rve, score 5.4e-11
316401019532	superfamily hit to SSF53098, Ribonuclease H-like, score 7.6e-07
316401019533	Transposase; Region: HTH_Tnp_1; cl17663
316401019534	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
316401019535	HMMPfam hit to PF01527, Transposase_8, score 6.2e-08
316401019536	putative transposase OrfB; Reviewed; Region: PHA02517
316401019537	HTH-like domain; Region: HTH_21; pfam13276
316401019538	Integrase core domain; Region: rve; pfam00665
316401019539	Integrase core domain; Region: rve_2; pfam13333
316401019540	superfamily hit to SSF53098, Ribonuclease H-like, score 5.3e-44
316401019541	HMMPfam hit to PF00665, rve, score 8.5e-50
316401019542	Heat-stable enterotoxin ST; Region: Enterotoxin_ST; pfam02048
316401019543	HMMPfam hit to PF02048, Enterotoxin_HS, score 1.9e-28
316401019544	superfamily hit to SSF89890, Proguanylin, score 0.0072
316401019545	Signal peptide predicted for p948.0360 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.790 between residues 19 and 20
316401019546	Transposase; Region: HTH_Tnp_1; cl17663
316401019547	superfamily hit to SSF46689, Homeodomain-like, score 0.0072
316401019548	HMMPfam hit to PF01527, Transposase_8, score 7.9e-13
316401019549	HTH-like domain; Region: HTH_21; pfam13276
316401019550	superfamily hit to SSF46785, 'Winged helix' DNA-binding domain, score 4.2e-08
316401019551	superfamily hit to SSF53098, Ribonuclease H-like, score 0.017
316401019552	putative fimbrial protein TcfA; Provisional; Region: PRK15308
316401019553	Signal peptide predicted for p948.0390 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.917 between residues 19 and 20
316401019554	superfamily hit to SSF49354, PapD-like, score 0.003
316401019555	CS1 type fimbrial major subunit; Region: Fimbrial_CS1; pfam04449
316401019556	Signal peptide predicted for p948.0400 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.914 between residues 23 and 24
316401019557	HMMPfam hit to PF04449, Fimbrial_CS1, score 9.2e-100
316401019558	fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310
316401019559	Signal peptide predicted for p948.0410 by SignalP 2.0 HMM (Signal peptide probability 0.922) with cleavage site probability 0.569 between residues 25 and 26
316401019560	CblD like pilus biogenesis initiator; Region: CblD; pfam07434
316401019561	Signal peptide predicted for p948.0420 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.711 between residues 23 and 24
316401019562	HMMPfam hit to PF07434, CblD, score 1.7e-258
316401019563	superfamily hit to SSF88633, Positive stranded ssRNA viruses, score 7.6e-06
316401019565	superfamily hit to SSF46689, Homeodomain-like, score 2.6e-11
316401019566	HMMPfam hit to PF00165, HTH_AraC, score 2.1e-12
316401019567	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
316401019568	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
316401019569	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
316401019570	IS2 repressor TnpA; Reviewed; Region: PRK09413
316401019571	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
316401019572	HMMPfam hit to PF01527, Transposase_8, score 1e-27
316401019573	superfamily hit to SSF46689, Homeodomain-like, score 7.4e-05
316401019574	IS2 transposase TnpB; Reviewed; Region: PRK09409
316401019575	HTH-like domain; Region: HTH_21; pfam13276
316401019576	Integrase core domain; Region: rve; pfam00665
316401019577	Integrase core domain; Region: rve_3; pfam13683
316401019578	superfamily hit to SSF53098, Ribonuclease H-like, score 3.1e-30
316401019579	HMMPfam hit to PF00665, rve, score 9.3e-34
316401019580	PAS fold; Region: PAS; pfam00989
316401019581	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
316401019582	superfamily hit to SSF55785, PYP-like sensor domain (PAS domain), score 1.9e-05
316401019583	HMMPfam hit to PF00989, PAS, score 4e-20
316401019584	TraM protein; Region: Tra_M; pfam05261
316401019585	HMMPfam hit to PF05261, Tra_M, score 2.7e-89
316401019586	superfamily hit to SSF47729, IHF-like DNA-binding proteins, score 7.3e-16
316401019587	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
316401019588	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
316401019589	N-acetyl-D-glucosamine binding site [chemical binding]; other site
316401019590	catalytic residue [active]
316401019591	1 probable transmembrane helix predicted for p948.0510 by TMHMM2.0 at aa 12-34
316401019592	superfamily hit to SSF53955, Lysozyme-like, score 1.3e-25
316401019593	HMMPfam hit to PF01464, SLT, score 5.4e-41
316401019594	1 probable transmembrane helix predicted for p948.0520 by TMHMM2.0 at aa 21-43
316401019595	Domain of unknown function (DUF932); Region: DUF932; pfam06067
316401019596	HMMPfam hit to PF06067, DUF932, score 3.3e-217
316401019597	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
316401019598	Transposase; Region: HTH_Tnp_1; cl17663
316401019599	superfamily hit to SSF46689, Homeodomain-like, score 5.9e-05
316401019600	HMMPfam hit to PF01527, Transposase_8, score 1.1e-16
316401019601	putative transposase OrfB; Reviewed; Region: PHA02517
316401019602	HTH-like domain; Region: HTH_21; pfam13276
316401019603	Integrase core domain; Region: rve; pfam00665
316401019604	Integrase core domain; Region: rve_3; pfam13683
316401019605	superfamily hit to SSF53098, Ribonuclease H-like, score 6.2e-45
316401019606	HMMPfam hit to PF00665, rve, score 2e-46
316401019607	putative transposase OrfB; Reviewed; Region: PHA02517
316401019608	HTH-like domain; Region: HTH_21; pfam13276
316401019609	Integrase core domain; Region: rve; pfam00665
316401019610	Integrase core domain; Region: rve_3; pfam13683
316401019611	HMMPfam hit to PF00665, rve, score 3.6e-44
316401019612	superfamily hit to SSF53098, Ribonuclease H-like, score 8.1e-41
316401019613	superfamily hit to SSF46785, 'Winged helix' DNA-binding domain, score 1.7e-07
316401019614	Transposase; Region: HTH_Tnp_1; cl17663
316401019615	superfamily hit to SSF46689, Homeodomain-like, score 0.0072
316401019616	HMMPfam hit to PF01527, Transposase_8, score 7.9e-13
316401019618	HMMPfam hit to PF02371, Transposase_20, score 8.8e-19
316401019619	small toxic polypeptide; Provisional; Region: PRK09738
316401019620	modulator of post-segregation killing protein; Provisional; Region: PRK13720
316401019621	HMMPfam hit to PF01848, HOK_GEF, score 2.6e-23
316401019622	1 probable transmembrane helix predicted for p948.0610 by TMHMM2.0 at aa 4-26
316401019623	superfamily hit to SSF52980, Restriction endonuclease-like, score 6.2e-06
316401019624	plasmid SOS inhibition protein A; Provisional; Region: PRK13704
316401019625	HMMPfam hit to PF06952, PsiA, score 2.8e-137
316401019626	deletion/fusion protein between putative methylase and psiB
316401019627	HMMPfam hit to PF06290, PsiB, score 3.1e-73
316401019628	superfamily hit to SSF53335, S-adenosyl-L-methionine-dependent methyltransferases, score 3.6e-27
316401019629	HMMPfam hit to PF01555, N6_N4_Mtase, score 4.2e-41
316401019630	Protein of unknown function (DUF1281); Region: DUF1281; pfam06924
316401019631	HMMPfam hit to PF06924, DUF1281, score 9.2e-131
316401019632	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
316401019633	PRTRC system protein D; Region: PRTRC_D; TIGR03739
316401019634	Mg binding site [ion binding]; other site
316401019635	nucleotide binding site [chemical binding]; other site
316401019636	putative protofilament interface [polypeptide binding]; other site
316401019637	HMMPfam hit to PF06406, StbA, score 1.9e-231
316401019638	superfamily hit to SSF53067, Actin-like ATPase domain, score 1.6e-49
316401019639	superfamily hit to SSF53067, Actin-like ATPase domain, score 8.6e-14
316401019640	Plasmid stability protein; Region: Plasmid_stab_B; pfam10784
316401019641	Signal peptide predicted for p948.0700 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.994 between residues 26 and 27
316401019642	7 probable transmembrane helices predicted for p948.0700 by TMHMM2.0 at aa 7-26, 31-46, 66-85, 90-112, 133-155, 170-192 and 213-235
316401019645	superfamily hit to SSF46689, Homeodomain-like, score 5.9e-05
316401019646	HMMPfam hit to PF01527, Transposase_8, score 1.1e-16
316401019647	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
316401019648	Helix-turn-helix domain; Region: HTH_38; pfam13936
316401019649	Integrase core domain; Region: rve; pfam00665
316401019650	superfamily hit to SSF46689, Homeodomain-like, score 2.3e-09
316401019651	superfamily hit to SSF46689, Homeodomain-like, score 5.9e-10
316401019652	HMMPfam hit to PF00665, rve, score 1.5e-33
316401019653	superfamily hit to SSF53098, Ribonuclease H-like, score 1.5e-27
316401019654	putative transposase OrfB; Reviewed; Region: PHA02517
316401019655	HTH-like domain; Region: HTH_21; pfam13276
316401019656	Integrase core domain; Region: rve; pfam00665
316401019657	Integrase core domain; Region: rve_3; pfam13683
316401019658	superfamily hit to SSF53098, Ribonuclease H-like, score 6.2e-45
316401019659	HMMPfam hit to PF00665, rve, score 2e-46
316401019660	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
316401019661	HMMPfam hit to PF05016, Plasmid_stabil, score 3.8e-17
316401019662	Predicted transcriptional regulator [Transcription]; Region: COG3905
316401019663	superfamily hit to SSF47598, Met repressor-like, score 9.6e-08
316401019664	HMMPfam hit to PF01402, RHH_1, score 4.6e-08
316401019666	superfamily hit to SSF52540, P-loop containing nucleoside triphosphate hydrolases, score 8.2e-20
316401019667	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
316401019668	HMMPfam hit to PF03400, Transposase_27, score 8.1e-104
316401019669	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
316401019670	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
316401019671	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
316401019672	HMMPfam hit to PF03811, Ins_element1, score 4.7e-65
316401019673	superfamily hit to SSF46689, Homeodomain-like, score 0.0011
316401019674	superfamily hit to SSF57783, Zinc beta-ribbon, score 0.0092
316401019676	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
316401019677	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
316401019678	catalytic residues [active]
316401019679	catalytic nucleophile [active]
316401019680	Presynaptic Site I dimer interface [polypeptide binding]; other site
316401019681	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
316401019682	Synaptic Flat tetramer interface [polypeptide binding]; other site
316401019683	Synaptic Site I dimer interface [polypeptide binding]; other site
316401019684	DNA binding site [nucleotide binding]
316401019685	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
316401019686	DNA-binding interface [nucleotide binding]; DNA binding site
316401019687	superfamily hit to SSF46689, Homeodomain-like, score 3.1e-08
316401019688	HMMPfam hit to PF02796, HTH_7, score 1.7e-11
316401019689	superfamily hit to SSF53041, Resolvase-like, score 7e-44
316401019690	HMMPfam hit to PF00239, Resolvase, score 1.1e-67
316401019691	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
316401019692	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
316401019693	HMMPfam hit to PF01526, Transposase_7, score 0
316401019694	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
316401019695	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
316401019696	Walker A/P-loop; other site
316401019697	ATP binding site [chemical binding]; other site
316401019698	Q-loop/lid; other site
316401019699	ABC transporter signature motif; other site
316401019700	Walker B; other site
316401019701	D-loop; other site
316401019702	H-loop/switch region; other site
316401019703	superfamily hit to SSF52540, P-loop containing nucleoside triphosphate hydrolases, score 7.5e-49
316401019704	HMMPfam hit to PF00005, ABC_tran, score 5.6e-46
316401019705	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
316401019706	Signal peptide predicted for p948.0880 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.990 between residues 23 and 24
316401019707	Outer membrane efflux protein; Region: OEP; pfam02321
316401019708	Outer membrane efflux protein; Region: OEP; pfam02321
316401019709	superfamily hit to SSF56954, Integral outer membrane protein TolC, efflux pump component, score 3.3e-15
316401019710	Signal peptide predicted for p948.0890 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.987 between residues 20 and 21
316401019711	HMMPfam hit to PF02687, FtsX, score 0.0018
316401019712	3 probable transmembrane helices predicted for p948.0900 by TMHMM2.0 at aa 21-43, 306-328 and 341-360
316401019713	Signal peptide predicted for p948.0910 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.936 between residues 19 and 20
316401019714	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
316401019715	HMMPfam hit to PF03400, Transposase_27, score 5.3e-110
316401019717	superfamily hit to SSF53098, Ribonuclease H-like, score 2.5e-15
316401019718	HMMPfam hit to PF00665, rve, score 1.5e-14
316401019719	Transposase; Region: HTH_Tnp_1; cl17663
316401019720	superfamily hit to SSF46689, Homeodomain-like, score 0.0072
316401019721	HMMPfam hit to PF01527, Transposase_8, score 7.9e-13
316401019722	putative transposase OrfB; Reviewed; Region: PHA02517
316401019723	HTH-like domain; Region: HTH_21; pfam13276
316401019724	Integrase core domain; Region: rve; pfam00665
316401019725	Integrase core domain; Region: rve_3; pfam13683
316401019726	superfamily hit to SSF46785, 'Winged helix' DNA-binding domain, score 1.7e-07
316401019727	superfamily hit to SSF53098, Ribonuclease H-like, score 7.2e-41
316401019728	HMMPfam hit to PF00665, rve, score 2.4e-44
316401019730	superfamily hit to SSF56317, Nitrilase/N-carbamoyl-D-aminoacid amidohydrolase, score 0.00066
316401019731	5 probable transmembrane helices predicted for p948.0990 by TMHMM2.0 at aa 15-37, 44-66, 71-93, 106-128 and 153-175
316401019734	HMMPfam hit to PF03050, Transposase_25, score 3.7e-126
316401019735	superfamily hit to SSF54197, HIT-like, score 2.3e-05
316401019736	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
316401019737	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
316401019738	HMMPfam hit to PF05717, Transposase_34, score 4.8e-69
316401019742	Transposase; Region: DEDD_Tnp_IS110; pfam01548
316401019743	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
316401019744	HMMPfam hit to PF02371, Transposase_20, score 1.8e-30
316401019745	HMMPfam hit to PF01548, Transposase_9, score 1.4e-27
316401019746	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
316401019747	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
316401019748	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316401019749	HMMPfam hit to PF00165, HTH_AraC, score 0.0013
316401019750	superfamily hit to SSF46689, Homeodomain-like, score 2.3e-13
316401019751	HMMPfam hit to PF00165, HTH_AraC, score 6.1e-13
316401019753	putative transposase OrfB; Reviewed; Region: PHA02517
316401019754	HTH-like domain; Region: HTH_21; pfam13276
316401019755	Integrase core domain; Region: rve; pfam00665
316401019756	Integrase core domain; Region: rve_3; pfam13683
316401019757	superfamily hit to SSF53098, Ribonuclease H-like, score 5.9e-45
316401019758	HMMPfam hit to PF00665, rve, score 3.9e-47
316401019759	Transposase; Region: HTH_Tnp_1; cl17663
316401019760	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
316401019761	superfamily hit to SSF46689, Homeodomain-like, score 0.0047
316401019762	HMMPfam hit to PF01527, Transposase_8, score 1.9e-12
316401019763	putative transposase OrfB; Reviewed; Region: PHA02517
316401019764	HTH-like domain; Region: HTH_21; pfam13276
316401019765	Integrase core domain; Region: rve; pfam00665
316401019766	Integrase core domain; Region: rve_3; pfam13683
316401019767	superfamily hit to SSF46785, 'Winged helix' DNA-binding domain, score 5.7e-08
316401019768	superfamily hit to SSF53098, Ribonuclease H-like, score 2e-40
316401019769	HMMPfam hit to PF00665, rve, score 1.4e-44
316401019770	Transposase; Region: HTH_Tnp_1; pfam01527
316401019771	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
316401019772	superfamily hit to SSF46689, Homeodomain-like, score 0.013
316401019773	HMMPfam hit to PF01527, Transposase_8, score 2e-22
316401019774	superfamily hit to SSF46689, Homeodomain-like, score 4.2e-06
316401019775	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
316401019776	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
316401019777	HMMPfam hit to PF05717, Transposase_34, score 1.1e-69
316401019778	superfamily hit to SSF54197, HIT-like, score 2.4e-09
316401019779	HMMPfam hit to PF03050, Transposase_25, score 1.6e-81