-- dump date 20140619_082230 -- class Genbank::Feature -- table feature -- table main -- field 1 id -- field 2 type -- field 3 name -- field 4 contig -- field 5 start_pos -- field 6 end_pos -- field 7 strand -- field 8 description -- field 9 chrom_position -- field 10 organism -- field 11 GeneID -- header -- id type name contig start_pos end_pos strand description chrom_position organism GeneID 331112000001 SEQ_END SEQ_END NC_009800.1 4643538 4643538 DR NC_009800.1; contig end 4643538..4643538 Escherichia coli HS YP_001456786.1 CDS thrL NC_009800.1 190 255 D identified by match to protein family HMM PF08254; match to protein family HMM TIGR02077; thr operon leader peptide 190..255 Escherichia coli HS 5591904 YP_001456787.1 CDS thrA NC_009800.1 336 2798 D multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartokinase I/homoserine dehydrogenase I 336..2798 Escherichia coli HS 5593169 YP_001456788.1 CDS thrB NC_009800.1 2800 3732 D catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 2800..3732 Escherichia coli HS 5591093 YP_001456789.1 CDS thrC NC_009800.1 3733 5019 D catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 3733..5019 Escherichia coli HS 5591094 YP_001456790.1 CDS EcHS_A0006 NC_009800.1 5309 5719 R identified by glimmer; hypothetical protein complement(5309..5719) Escherichia coli HS 5591095 YP_001456791.1 CDS EcHS_A0007 NC_009800.1 5682 6458 R yaaA; identified by similarity to SP:Q8ZS17; match to protein family HMM PF03883; hypothetical protein complement(5682..6458) Escherichia coli HS 5591096 YP_001456792.1 CDS agcS NC_009800.1 6528 7958 R identified by match to protein family HMM PF01235; match to protein family HMM TIGR00835; amino acid carrier protein complement(6528..7958) Escherichia coli HS 5593814 YP_001456793.1 CDS tal2 NC_009800.1 8237 9190 D identified by match to protein family HMM PF00923; match to protein family HMM TIGR00874; transaldolase B 8237..9190 Escherichia coli HS 5593815 YP_001456794.1 CDS mogA NC_009800.1 9305 9892 D forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein 9305..9892 Escherichia coli HS 5593816 YP_001456795.1 CDS EcHS_A0011 NC_009800.1 9927 10493 R yaaH; identified by match to protein family HMM PF01184; hypothetical protein complement(9927..10493) Escherichia coli HS 5595005 YP_001456796.1 CDS EcHS_A0012 NC_009800.1 10642 11355 R identified by match to protein family HMM PF03667; hypothetical protein complement(10642..11355) Escherichia coli HS 5595006 YP_001456797.1 CDS EcHS_A0013 NC_009800.1 11381 11785 R yaaI; hypothetical protein complement(11381..11785) Escherichia coli HS 5595007 YP_001456798.1 CDS EcHS_A0014 NC_009800.1 11920 12069 R identified by glimmer; hypothetical protein complement(11920..12069) Escherichia coli HS 5594567 YP_001456799.1 CDS dnaK NC_009800.1 12162 14078 D heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 12162..14078 Escherichia coli HS 5594568 YP_001456800.1 CDS dnaJ NC_009800.1 14167 15297 D chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; molecular chaperone DnaJ 14167..15297 Escherichia coli HS 5594569 YP_001456801.1 CDS EcHS_A0017 NC_009800.1 15560 16672 R identified by match to protein family HMM PF01609; IS186, transposase complement(15560..16672) Escherichia coli HS 5592785 YP_001456802.1 CDS EcHS_A0018 NC_009800.1 16750 16959 R identified by match to protein family HMM PF01848; Hok/gef family protein complement(16750..16959) Escherichia coli HS 5592786 YP_001456803.1 CDS nhaA NC_009800.1 17488 18654 D exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH; pH-dependent sodium/proton antiporter 17488..18654 Escherichia coli HS 5592787 YP_001456804.1 CDS nhaR NC_009800.1 18720 19619 D Na+/H+ antiporter regulatory protein; activates the genes nhaA and osmC; transcriptional activator NhaR 18720..19619 Escherichia coli HS 5594526 YP_001456805.1 CDS EcHS_A0021 NC_009800.1 19658 20437 R NULL; identified by similarity to GB:AAZ86820.1; hypothetical protein complement(19658..20437) Escherichia coli HS 5594527 YP_001456806.1 CDS EcHS_A4640 NC_009800.1 22207 22770 R identified by glimmer; hypothetical protein complement(22207..22770) Escherichia coli HS 5593267 YP_001456807.1 CDS EcHS_A0024 NC_009800.1 22812 23627 R NULL; identified by glimmer; hypothetical protein complement(22812..23627) Escherichia coli HS 5593268 YP_001456808.1 CDS rpsT NC_009800.1 24111 24374 R binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 complement(24111..24374) Escherichia coli HS 5593269 YP_001456809.1 CDS EcHS_A0026 NC_009800.1 24477 24695 D yaaY; identified by similarity to GB:AAZ86826.1; hypothetical protein 24477..24695 Escherichia coli HS 5594902 YP_001456810.1 CDS ribF NC_009800.1 24703 25644 D catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 24703..25644 Escherichia coli HS 5594903 YP_001456811.1 CDS ileS NC_009800.1 25687 28503 D IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 25687..28503 Escherichia coli HS 5594904 YP_001456812.1 CDS lspA NC_009800.1 28503 28997 D lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 28503..28997 Escherichia coli HS 5593740 YP_001456813.1 CDS fkpB NC_009800.1 29085 29534 D identified by match to protein family HMM PF00254; FKBP-type peptidylprolyl isomerase 29085..29534 Escherichia coli HS 5593741 YP_001456814.1 CDS ispH NC_009800.1 29536 30486 D catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 29536..30486 Escherichia coli HS 5593742 YP_001456815.1 CDS rihC NC_009800.1 30552 31466 D catalyzes the hydrolysis of both purine and pyrimidine ribonucleosides; ribonucleoside hydrolase RihC 30552..31466 Escherichia coli HS 5594057 YP_001456816.1 CDS dapB NC_009800.1 31633 32454 D catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 31633..32454 Escherichia coli HS 5594058 YP_001456817.1 CDS EcHS_A0034 NC_009800.1 32496 32663 R identified by glimmer; hypothetical protein complement(32496..32663) Escherichia coli HS 5594059 YP_001456818.1 CDS carA NC_009800.1 32910 34058 D catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 32910..34058 Escherichia coli HS 5593830 YP_001456819.1 CDS carB NC_009800.1 34076 37297 D four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 34076..37297 Escherichia coli HS 5593831 YP_001456820.1 CDS EcHS_A0037 NC_009800.1 37305 37523 R identified by glimmer; hypothetical protein complement(37305..37523) Escherichia coli HS 5593832 YP_001456821.1 CDS caiF NC_009800.1 37558 37953 D regulator of carnitine metabolism; induces the caiTABCDE and fixABCX operons; DNA-binding transcriptional activator CaiF 37558..37953 Escherichia coli HS 5593861 YP_001456822.1 CDS caiE NC_009800.1 38039 38629 R involved in the synthesis of a cofactor required for carnitine dehydratase and carnitine racemase activities; carnitine operon protein CaiE complement(38039..38629) Escherichia coli HS 5593862 YP_001456823.2 CDS caiD NC_009800.1 38635 39420 R catalyzes the dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA; carnitinyl-CoA dehydratase complement(38635..39420) Escherichia coli HS 5593863 YP_001456824.1 CDS caiC NC_009800.1 39529 41097 R identified by match to protein family HMM PF00501; crotonobetaine/carnitine-CoA ligase complement(39529..41097) Escherichia coli HS 5591851 YP_001456825.1 CDS caiB NC_009800.1 41156 42373 R catalyzes formation of L-carnitinyl-CoA by transfering the CoA moiety from gamma-butyrobetainyl-CoA, also catalyzes the formation of crotonobetainyl-CoA by transfer of CoA from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine; crotonobetainyl-CoA:carnitine CoA-transferase complement(41156..42373) Escherichia coli HS 5591852 YP_001456826.1 CDS caiA NC_009800.1 42502 43644 R catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA; crotonobetainyl-CoA dehydrogenase complement(42502..43644) Escherichia coli HS 5591853 YP_001456827.1 CDS caiT NC_009800.1 43675 45189 R catalyzes the exchange of L-carnitine for gamma-butyrobetaine in carnitine metabolism; L-carnitine/gamma-butyrobetaine antiporter complement(43675..45189) Escherichia coli HS 5592023 YP_001456828.1 CDS EcHS_A0045 NC_009800.1 45204 45305 D identified by glimmer; hypothetical protein 45204..45305 Escherichia coli HS 5592024 YP_001456829.1 CDS EcHS_A0046 NC_009800.1 45484 45594 D identified by similarity to GB:AAX63975.1; hypothetical protein 45484..45594 Escherichia coli HS 5592025 YP_001456830.1 CDS fixA NC_009800.1 45663 46433 D required for anaerobic carnitine reduction, may act to transfer electrons to crotonobetaine reductase; electron transfer flavoprotein FixA 45663..46433 Escherichia coli HS 5591071 YP_001456831.1 CDS fixB NC_009800.1 46448 47389 D involved in electron transfer during carnitine metabolism; electron transfer flavoprotein FixB 46448..47389 Escherichia coli HS 5591072 YP_001456832.1 CDS fixC NC_009800.1 47440 48726 D FAD/NAD(P)-binding domain; possibly part of an electron transfer system required for anaerobic carnitine reduction; oxidoreductase FixC 47440..48726 Escherichia coli HS 5591073 YP_001456833.1 CDS fixX NC_009800.1 48723 49010 D identified by similarity to SP:P68646; ferredoxin FixX-like protein 48723..49010 Escherichia coli HS 5592752 YP_001456834.1 CDS EcHS_A0051 NC_009800.1 49069 50400 D identified by match to protein family HMM PF00083; match to protein family HMM PF07690; major facilitator family transporter 49069..50400 Escherichia coli HS 5592753 YP_001456835.1 CDS kefF NC_009800.1 50508 51038 D Required for full activity of KefC, a potassium-proton antiporter; glutathione-regulated potassium-efflux system ancillary protein KefF 50508..51038 Escherichia coli HS 5592754 YP_001456836.1 CDS kefC NC_009800.1 51031 52893 D transport system that facilitates potassium-efflux; glutathione-regulated potassium-efflux system protein KefC 51031..52893 Escherichia coli HS 5592631 YP_001456837.1 CDS folA NC_009800.1 53085 53564 D catalyzes the reduction of dihydrofolate to tetrahydrofolate; dihydrofolate reductase 53085..53564 Escherichia coli HS 5592632 YP_001456838.1 CDS apaH NC_009800.1 53642 54484 R hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; diadenosine tetraphosphatase complement(53642..54484) Escherichia coli HS 5592633 YP_001456839.1 CDS apaG NC_009800.1 54491 54868 R protein associated with Co2+ and Mg2+ efflux; ApaG complement(54491..54868) Escherichia coli HS 5592041 YP_001456840.1 CDS ksgA NC_009800.1 54871 55692 R catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase complement(54871..55692) Escherichia coli HS 5592042 YP_001456841.1 CDS pdxA NC_009800.1 55689 56678 R catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate); 4-hydroxythreonine-4-phosphate dehydrogenase complement(55689..56678) Escherichia coli HS 5592043 YP_001456842.1 CDS surA NC_009800.1 56678 57964 R Chaperone involved in the folding of extracytoplasmic proteins, especially OmpA, OmpF and LamB; peptidyl-prolyl cis-trans isomerase SurA complement(56678..57964) Escherichia coli HS 5595320 YP_001456843.1 CDS imp NC_009800.1 58017 60371 R determines N-hexane tolerance and is involved in outer membrane permeability; organic solvent tolerance protein complement(58017..60371) Escherichia coli HS 5595321 YP_001456844.1 CDS djlA NC_009800.1 60626 61441 D functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system; Dna-J like membrane chaperone protein 60626..61441 Escherichia coli HS 5595322 YP_001456845.1 CDS EcHS_A0062 NC_009800.1 61558 62217 R catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs; 23S rRNA/tRNA pseudouridine synthase A complement(61558..62217) Escherichia coli HS 5592464 YP_001456846.1 CDS rapA NC_009800.1 62229 65135 R transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA; ATP-dependent helicase HepA complement(62229..65135) Escherichia coli HS 5592465 YP_001456847.1 CDS polB NC_009800.1 65300 67651 R Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C; DNA polymerase II complement(65300..67651) Escherichia coli HS 5592466 YP_001456848.1 CDS araD NC_009800.1 67726 68421 R catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase complement(67726..68421) Escherichia coli HS 5593124 YP_001456849.1 CDS araA NC_009800.1 68590 70092 R catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism; L-arabinose isomerase complement(68590..70092) Escherichia coli HS 5593125 YP_001456850.1 CDS araB NC_009800.1 70103 71803 R catalyzes the phosphorylation of ribulose to ribulose 5-phosphate; ribulokinase complement(70103..71803) Escherichia coli HS 5593126 YP_001456851.1 CDS araC NC_009800.1 72142 73020 D positive and negative regulator; regulates the araBAD and araFGH operons and other genes involved in the transport and catabolism of L-arabinose; DNA-binding transcriptional regulator AraC 72142..73020 Escherichia coli HS 5594097 YP_001456852.1 CDS EcHS_A0069 NC_009800.1 73106 73870 D yabI; identified by similarity to SP:P30149; match to protein family HMM PF09335; hypothetical protein 73106..73870 Escherichia coli HS 5594098 YP_001456853.1 CDS thiQ NC_009800.1 73984 74682 R with TbpA and ThiP is part of the thiamine and TPP transport system; thiamine transporter ATP-binding subunit complement(73984..74682) Escherichia coli HS 5594099 YP_001456854.1 CDS thiP NC_009800.1 74666 76276 R permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine; thiamine transporter membrane protein complement(74666..76276) Escherichia coli HS 5592150 YP_001456855.1 CDS tbpA NC_009800.1 76252 77235 R part of the thiamine and TPP transport system tbpA-thiPQ; thiamine transporter substrate binding subunit complement(76252..77235) Escherichia coli HS 5592151 YP_001456856.1 CDS EcHS_A0073 NC_009800.1 77279 77398 R lipoprotein complement(77279..77398) Escherichia coli HS 5592152 YP_001456857.1 CDS sgrR NC_009800.1 77399 79054 R activates sgrS under glucose-phosphate stress conditions; transcriptional regulator SgrR complement(77399..79054) Escherichia coli HS 5595447 YP_001456858.1 CDS setA NC_009800.1 79376 80554 D identified by similarity to SP:P31675; match to protein family HMM PF07690; match to protein family HMM TIGR00899; sugar efflux transporter A 79376..80554 Escherichia coli HS 5595448 YP_001456859.1 CDS leuD NC_009800.1 80603 81208 R catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit complement(80603..81208) Escherichia coli HS 5595449 YP_001456860.1 CDS leuC NC_009800.1 81219 82619 R dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit complement(81219..82619) Escherichia coli HS 5592811 YP_001456861.1 CDS leuB NC_009800.1 82622 83713 R catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase complement(82622..83713) Escherichia coli HS 5592812 YP_001456862.1 CDS leuA NC_009800.1 83713 85284 R catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis; 2-isopropylmalate synthase complement(83713..85284) Escherichia coli HS 5592813 YP_001456863.1 CDS leuL NC_009800.1 85377 85463 R involved in attenuation control of the leuABCD operon in leucine biosynthesis; leu operon leader peptide complement(85377..85463) Escherichia coli HS 5595485 YP_001456864.1 CDS leuO NC_009800.1 86123 87067 D activator for leuABCD operon; member of LysR family of transcriptional activators; leucine transcriptional activator 86123..87067 Escherichia coli HS 5595486 YP_001456865.1 CDS EcHS_A0082 NC_009800.1 87103 87225 R identified by glimmer; hypothetical protein complement(87103..87225) Escherichia coli HS 5595487 YP_001456866.1 CDS ilvI NC_009800.1 87385 89109 D catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; acetolactate synthase 3 catalytic subunit 87385..89109 Escherichia coli HS 5593599 YP_001456867.1 CDS ilvH NC_009800.1 89112 89603 D with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 89112..89603 Escherichia coli HS 5593600 YP_001456868.1 CDS EcHS_A0085 NC_009800.1 89655 89786 D identified by glimmer; hypothetical protein 89655..89786 Escherichia coli HS 5593601 YP_001456869.1 CDS fruR NC_009800.1 89783 90787 D binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism; DNA-binding transcriptional regulator FruR 89783..90787 Escherichia coli HS 5594241 YP_001456870.1 CDS mraZ NC_009800.1 91389 91847 D MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 91389..91847 Escherichia coli HS 5594242 YP_001456871.1 CDS mraW NC_009800.1 91849 92790 D identified by match to protein family HMM PF01795; match to protein family HMM TIGR00006; S-adenosyl-methyltransferase MraW 91849..92790 Escherichia coli HS 5594243 YP_001456872.1 CDS ftsL NC_009800.1 92787 93152 D membrane bound cell division protein at septum containing leucine zipper motif; cell division protein FtsL 92787..93152 Escherichia coli HS 5591286 YP_001456873.1 CDS ftsI NC_009800.1 93168 94934 D identified by similarity to SP:P0AD68; match to protein family HMM PF00905; match to protein family HMM PF03717; peptidoglycan synthetase FtsI 93168..94934 Escherichia coli HS 5591287 YP_001456874.1 CDS murE NC_009800.1 94921 96408 D involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 94921..96408 Escherichia coli HS 5591288 YP_001456875.1 CDS murF NC_009800.1 96405 97763 D identified by similarity to SP:P11880; match to protein family HMM PF01225; match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01143; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase 96405..97763 Escherichia coli HS 5594238 YP_001456876.1 CDS mraY NC_009800.1 97757 98839 D First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 97757..98839 Escherichia coli HS 5594239 YP_001456877.1 CDS murD NC_009800.1 98842 100158 D UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 98842..100158 Escherichia coli HS 5594240 YP_001456878.1 CDS ftsW NC_009800.1 100158 101402 D integral membrane protein involved in stabilizing FstZ ring during cell division; cell division protein FtsW 100158..101402 Escherichia coli HS 5590909 YP_001456879.1 CDS murG NC_009800.1 101399 102466 D UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 101399..102466 Escherichia coli HS 5590910 YP_001456880.1 CDS murC NC_009800.1 102520 103995 D Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 102520..103995 Escherichia coli HS 5590911 YP_001456881.1 CDS ddl NC_009800.1 103988 104908 D D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanine--D-alanine ligase 103988..104908 Escherichia coli HS 5594091 YP_001456882.1 CDS ftsQ NC_009800.1 104910 105740 D involved in septum formation; cell division protein FtsQ 104910..105740 Escherichia coli HS 5594092 YP_001456883.1 CDS ftsA NC_009800.1 105737 106999 D ATP-binding involved in recruitment of FtsK to Z ring; essential cell division protein; colocalizes with FtsZ through direct interaction to the septal ring structure; structurally similar to eukaryotic actin; binds directly to the cell membrane; cell division protein FtsA 105737..106999 Escherichia coli HS 5594093 YP_001456884.1 CDS ftsZ NC_009800.1 107060 108211 D GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 107060..108211 Escherichia coli HS 5591065 YP_001456885.1 CDS lpxC NC_009800.1 108312 109229 D zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 108312..109229 Escherichia coli HS 5591066 YP_001456886.1 CDS secM NC_009800.1 109385 109972 D secM translational pause allows for the initiation of secA translation; SecA regulator SecM 109385..109972 Escherichia coli HS 5591067 YP_001456887.1 CDS secA NC_009800.1 110034 112739 D functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 110034..112739 Escherichia coli HS 5590912 YP_001456888.1 CDS mutT NC_009800.1 112799 113188 D identified by match to protein family HMM PF00293; match to protein family HMM TIGR00586; nucleoside triphosphate pyrophosphohydrolase 112799..113188 Escherichia coli HS 5590913 YP_001456889.1 CDS EcHS_A0106 NC_009800.1 113288 113485 R identified by similarity to SP:P0A8H8; match to protein family HMM PF03884; zinc-binding protein complement(113288..113485) Escherichia coli HS 5590914 YP_001456890.1 CDS EcHS_A0107 NC_009800.1 113495 114238 R yacF; identified by match to protein family HMM PF07072; hypothetical protein complement(113495..114238) Escherichia coli HS 5591080 YP_001456891.1 CDS coaE NC_009800.1 114238 114858 R catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase complement(114238..114858) Escherichia coli HS 5591081 YP_001456892.1 CDS guaC NC_009800.1 115083 116126 D catalyzes the NADPH-dependent deamination of GMP to inosine monophosphate; guanosine 5'-monophosphate oxidoreductase 115083..116126 Escherichia coli HS 5591082 YP_001456893.1 CDS pilC NC_009800.1 116161 117363 R identified by match to protein family HMM PF00482; type IV pilin biogenesis protein complement(116161..117363) Escherichia coli HS 5593054 YP_001456894.1 CDS hofB NC_009800.1 117353 118738 R identified by match to protein family HMM PF00437; hypothetical protein complement(117353..118738) Escherichia coli HS 5593055 YP_001456895.1 CDS nadC NC_009800.1 119391 120284 R catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; quinolinate phosphoribosyltransferase complement(119391..120284) Escherichia coli HS 5591691 YP_001456896.1 CDS ampD NC_009800.1 120372 120923 D identified by similarity to SP:P13016; match to protein family HMM PF01510; N-acetyl-anhydromuranmyl-L-alanine amidase 120372..120923 Escherichia coli HS 5591692 YP_001456897.1 CDS ampE NC_009800.1 120920 121774 D involved in regulation of beta-lactamase; signaling protein; regulatory protein AmpE 120920..121774 Escherichia coli HS 5591693 YP_001456898.1 CDS aroP NC_009800.1 121817 123187 R identified by similarity to SP:P15993; match to protein family HMM PF00324; aromatic amino acid transporter complement(121817..123187) Escherichia coli HS 5592525 YP_001456899.1 CDS pdhR NC_009800.1 123731 124495 D activates lctPRD operon; autoregulates itself through repression of pdhR-aceEF-lpdA operon; regulates pyruvate dehydrogenase complex; transcriptional regulator PdhR 123731..124495 Escherichia coli HS 5592526 YP_001456900.1 CDS aceE NC_009800.1 124656 127319 D E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 124656..127319 Escherichia coli HS 5592527 YP_001456901.1 CDS aceF NC_009800.1 127334 129226 D E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains; dihydrolipoamide acetyltransferase 127334..129226 Escherichia coli HS 5595158 YP_001456902.1 CDS lpdA NC_009800.1 129551 130975 D E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 129551..130975 Escherichia coli HS 5595159 YP_001456903.1 CDS EcHS_A0121 NC_009800.1 131046 132899 R hypothetical protein complement(131046..132899) Escherichia coli HS 5595160 YP_001456904.1 CDS acnB NC_009800.1 133254 135851 D catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate; bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase 133254..135851 Escherichia coli HS 5591000 YP_001456905.1 CDS EcHS_A0123 NC_009800.1 136027 136389 D yacL; identified by similarity to SP:P59396; match to protein family HMM PF06062; hypothetical protein 136027..136389 Escherichia coli HS 5591001 YP_001456906.1 CDS speD NC_009800.1 136427 137221 R S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine; S-adenosylmethionine decarboxylase complement(136427..137221) Escherichia coli HS 5591002 YP_001456907.1 CDS speE NC_009800.1 137237 138103 R catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase complement(137237..138103) Escherichia coli HS 5593793 YP_001456908.1 CDS EcHS_A0127 NC_009800.1 138209 138556 R yacC; hypothetical protein complement(138209..138556) Escherichia coli HS 5593794 YP_001456909.1 CDS cueO NC_009800.1 138683 140272 D laccase; copper-stimulated phenoloxidase and ferroxidase which may be involved in copper detoxification; multicopper oxidase 138683..140272 Escherichia coli HS 5593795 YP_001456910.1 CDS gcd NC_009800.1 140319 142709 R identified by similarity to SP:P15877; match to protein family HMM PF01011; match to protein family HMM TIGR03074; glucose dehydrogenase complement(140319..142709) Escherichia coli HS 5592492 YP_001456911.1 CDS hpt NC_009800.1 142915 143451 D identified by similarity to SP:P0A9M2; match to protein family HMM PF00156; match to protein family HMM TIGR01203; hypoxanthine phosphoribosyltransferase 142915..143451 Escherichia coli HS 5592493 YP_001456912.1 CDS can NC_009800.1 143492 144154 R catalyzes the interconversion of bicarbonate and carbon dioxide; carbonic anhydrase complement(143492..144154) Escherichia coli HS 5592494 YP_001456913.1 CDS EcHS_A0131 NC_009800.1 144263 145189 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 144263..145189 Escherichia coli HS 5594511 YP_001456914.1 CDS EcHS_A0132 NC_009800.1 145186 145956 D identified by match to protein family HMM PF01061; ABC transporter permease 145186..145956 Escherichia coli HS 5594512 YP_001456915.1 CDS EcHS_A0133 NC_009800.1 146061 146501 D identified by match to protein family HMM PF03610; PTS system IIA component domain-containing protein 146061..146501 Escherichia coli HS 5594513 YP_001456916.1 CDS EcHS_A0134 NC_009800.1 146565 147794 D identified by match to protein family HMM PF01522; polysaccharide deacetylase 146565..147794 Escherichia coli HS 5591459 YP_001456917.1 CDS panD NC_009800.1 147798 148178 R Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase complement(147798..148178) Escherichia coli HS 5591460 YP_001456918.1 CDS EcHS_A0136 NC_009800.1 148637 149353 D identified by match to protein family HMM PF04754; match to protein family HMM TIGR01784; hypothetical protein 148637..149353 Escherichia coli HS 5591461 YP_001456919.1 CDS panC NC_009800.1 149427 150278 R catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase complement(149427..150278) Escherichia coli HS 5593359 YP_001456920.1 CDS panB NC_009800.1 150290 151084 R catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase complement(150290..151084) Escherichia coli HS 5593360 YP_001456921.1 CDS EcHS_A0139 NC_009800.1 151197 152471 R identified by match to protein family HMM PF00419; fimbrial-like adhesin protein complement(151197..152471) Escherichia coli HS 5593361 YP_001456922.1 CDS EcHS_A0140 NC_009800.1 152524 153120 R identified by similarity to GB:AAZ86939.1; hypothetical protein complement(152524..153120) Escherichia coli HS 5593975 YP_001456923.1 CDS EcHS_A0141 NC_009800.1 153232 154044 R identified by similarity to GB:AAP17067.1; match to protein family HMM PF00665; ISEhe3, transposase orfB complement(153232..154044) Escherichia coli HS 5593976 YP_001456924.1 CDS EcHS_A0142 NC_009800.1 154101 154379 R identified by similarity to GB:AAP19558.1; match to protein family HMM PF01527; ISEhe3, transposase orfA complement(154101..154379) Escherichia coli HS 5593977 YP_001456925.1 CDS EcHS_A0143 NC_009800.1 154502 155242 R identified by match to protein family HMM PF00345; match to protein family HMM PF02753; chaperone protein EcpD complement(154502..155242) Escherichia coli HS 5595042 YP_001456926.1 CDS folK NC_009800.1 156301 156780 R catalyzes the formation of 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine and ATP; 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase complement(156301..156780) Escherichia coli HS 5595044 YP_001456927.1 CDS pcnB NC_009800.1 156777 158141 R Polymerase that creates the 3' poly(A) tail found in some mRNA's; poly(A) polymerase complement(156777..158141) Escherichia coli HS 5592251 YP_001456928.1 CDS gluQ NC_009800.1 158234 159160 R this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu; glutamyl-Q tRNA(Asp) synthetase complement(158234..159160) Escherichia coli HS 5592252 YP_001456929.1 CDS dksA NC_009800.1 159197 159652 R identified by match to protein family HMM PF01258; match to protein family HMM TIGR02420; DnaK transcriptional regulator DksA complement(159197..159652) Escherichia coli HS 5592253 YP_001456930.1 CDS sfsA NC_009800.1 159830 160534 R Regulatory factor involved in maltose metabolism; sugar fermentation stimulation protein A complement(159830..160534) Escherichia coli HS 5593463 YP_001456931.1 CDS ligT NC_009800.1 160549 161079 R identified by similarity to SP:P37025; match to protein family HMM PF02834; match to protein family HMM TIGR02258; 2'-5' RNA ligase complement(160549..161079) Escherichia coli HS 5593464 YP_001456932.1 CDS hrpB NC_009800.1 161153 163582 D similar in sequence to the ATP-dependent RNA helicase HrpA; ATP-dependent RNA helicase HrpB 161153..163582 Escherichia coli HS 5593465 YP_001456933.1 CDS mrcB NC_009800.1 163778 166312 D bifunctional periplasmic enzyme; contains transglycosylase and transpeptidase activity; major enzyme for peptidoglycan biosynthesis in Escherichia coli; transmembrane protein; forms dimers; three variants, one of which may be a degradation product, while the other appears to result from an alternative initiation site, are found within the cell; penicillin-binding protein 1b 163778..166312 Escherichia coli HS 5595317 YP_001456934.1 CDS EcHS_A0153 NC_009800.1 166377 166511 R identified by glimmer; hypothetical protein complement(166377..166511) Escherichia coli HS 5595318 YP_001456935.1 CDS fhuA NC_009800.1 166532 168721 D involved with the transport of ferrichrome across the outer membrane; binds the ferrichrome-iron ligand and interacts with the TonB protein; ferrichrome outer membrane transporter 166532..168721 Escherichia coli HS 5595319 YP_001456936.1 CDS fhuC NC_009800.1 168772 169569 D part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; iron-hydroxamate transporter ATP-binding subunit 168772..169569 Escherichia coli HS 5592316 YP_001456937.1 CDS fhuD NC_009800.1 169569 170459 D Part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; binds to all hydroxamate siderophores; iron-hydroxamate transporter substrate-binding subunit 169569..170459 Escherichia coli HS 5592317 YP_001456938.1 CDS fhuB NC_009800.1 170456 172438 D part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome; iron-hydroxamate transporter permease subunit 170456..172438 Escherichia coli HS 5592318 YP_001456939.1 CDS hemL NC_009800.1 172473 173753 R Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase complement(172473..173753) Escherichia coli HS 5591950 YP_001456940.1 CDS clcA NC_009800.1 173978 175399 D Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation; chloride channel protein 173978..175399 Escherichia coli HS 5591951 YP_001456941.1 CDS yadR NC_009800.1 175481 175825 D essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors; iron-sulfur cluster insertion protein ErpA 175481..175825 Escherichia coli HS 5591952 YP_001456942.1 CDS EcHS_A0161 NC_009800.1 175872 176495 R yadS; identified by match to protein family HMM PF03458; hypothetical protein complement(175872..176495) Escherichia coli HS 5592778 YP_001456943.1 CDS btuF NC_009800.1 176533 177333 R solute binding component of the vitamin B12 transport system BtuCDF; vitamin B12-transporter protein BtuF complement(176533..177333) Escherichia coli HS 5592779 YP_001456944.1 CDS mtnN NC_009800.1 177326 178024 R enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase complement(177326..178024) Escherichia coli HS 5592780 YP_001456945.1 CDS dgt NC_009800.1 178108 179625 D forms a homotetramer; requires magnesium for activity; catalyzes the hydrolysis of dGTP to form deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase 178108..179625 Escherichia coli HS 5591881 YP_001456946.1 CDS degP NC_009800.1 179755 181179 D protease Do; required at high temperature; degrades damaged proteins; serine endoprotease 179755..181179 Escherichia coli HS 5591882 YP_001456947.1 CDS cdaR NC_009800.1 181334 182491 D regulates the expression of the operons for the enzymes involved in galactarate, glucarate and glycerate utilization; carbohydrate diacid transcriptional activator CdaR 181334..182491 Escherichia coli HS 5591883 YP_001456948.1 CDS EcHS_A0167 NC_009800.1 182580 182966 R hypothetical protein complement(182580..182966) Escherichia coli HS 5594267 YP_001456949.1 CDS dapD NC_009800.1 183281 184105 R catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase complement(183281..184105) Escherichia coli HS 5594268 YP_001456950.1 CDS glnD NC_009800.1 184136 186808 R catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein; PII uridylyl-transferase complement(184136..186808) Escherichia coli HS 5594269 YP_001456951.1 CDS map NC_009800.1 186870 187664 R catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase complement(186870..187664) Escherichia coli HS 5594715 YP_001456952.1 CDS rpsB NC_009800.1 188032 188757 D one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 188032..188757 Escherichia coli HS 5594717 YP_001456953.1 CDS tsf NC_009800.1 189015 189866 D EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 189015..189866 Escherichia coli HS 5593802 YP_001456954.1 CDS pyrH NC_009800.1 190013 190738 D Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 190013..190738 Escherichia coli HS 5593803 YP_001456955.1 CDS frr NC_009800.1 191030 191587 D Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 191030..191587 Escherichia coli HS 5591018 YP_001456956.1 CDS dxr NC_009800.1 191679 192875 D catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 191679..192875 Escherichia coli HS 5591019 YP_001456957.1 CDS uppS NC_009800.1 193063 193821 D catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 193063..193821 Escherichia coli HS 5591020 YP_001456958.1 CDS cdsA NC_009800.1 193834 194691 D catalyzes the synthesis of CDP-diglyceride from CTP and phosphatidate; CDP-diglyceride synthase 193834..194691 Escherichia coli HS 5594329 YP_001456959.1 CDS rseP NC_009800.1 194703 196055 D catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response; zinc metallopeptidase RseP 194703..196055 Escherichia coli HS 5594330 YP_001456960.1 CDS yaeT NC_009800.1 196085 198517 D part of a complex with YfgL, YfiO, and NlpB involved in outer membrane protein biosynthesis; involved in the assembly of outer membrane proteins; outer membrane protein assembly factor YaeT 196085..198517 Escherichia coli HS 5594331 YP_001456961.1 CDS skp NC_009800.1 198639 199124 D identified by similarity to SP:P31519; match to protein family HMM PF03938; periplasmic chaperone 198639..199124 Escherichia coli HS 5594073 YP_001456962.1 CDS lpxD NC_009800.1 199128 200153 D adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 199128..200153 Escherichia coli HS 5594074 YP_001456963.1 CDS fabZ NC_009800.1 200258 200713 D in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 200258..200713 Escherichia coli HS 5594075 YP_001456964.1 CDS lpxA NC_009800.1 200717 201505 D catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 200717..201505 Escherichia coli HS 5593291 YP_001456965.1 CDS lpxB NC_009800.1 201505 202653 D catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; lipid-A-disaccharide synthase 201505..202653 Escherichia coli HS 5593292 YP_001456966.1 CDS rnhB NC_009800.1 202650 203246 D RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 202650..203246 Escherichia coli HS 5593293 YP_001456967.1 CDS dnaE NC_009800.1 203283 206765 D catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 203283..206765 Escherichia coli HS 5593439 YP_001456968.1 CDS accA NC_009800.1 206778 207737 D catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 206778..207737 Escherichia coli HS 5593440 YP_001456969.1 CDS ldcC1 NC_009800.1 207836 209977 D identified by similarity to SP:P52095; match to protein family HMM PF01276; match to protein family HMM PF03709; match to protein family HMM PF03711; lysine decarboxylase, constitutive 207836..209977 Escherichia coli HS 5593441 YP_001456970.1 CDS EcHS_A0189 NC_009800.1 210034 210423 D identified by match to protein family HMM PF00903; hypothetical protein 210034..210423 Escherichia coli HS 5592794 YP_001456971.1 CDS tilS NC_009800.1 210488 211786 D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU; ATP-dependent; responsible for modifying the wobble-base of the CAU anticodon of tRNAIle such that it exhibits proper recognition of the AUA codon rather than the AUG codon and is in turn properly recognized by isoleucyl-tRNA synthetase; tRNA(Ile)-lysidine synthetase 210488..211786 Escherichia coli HS 5592795 YP_001456972.1 CDS rof NC_009800.1 211835 212095 R Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination; Rho-binding antiterminator complement(211835..212095) Escherichia coli HS 5592796 YP_001456973.1 CDS EcHS_A0192 NC_009800.1 212082 212282 R identified by match to protein family HMM PF06786; hypothetical protein complement(212082..212282) Escherichia coli HS 5593989 YP_001456974.1 CDS EcHS_A0193 NC_009800.1 212448 212993 D yaeQ; identified by match to protein family HMM PF07152; hypothetical protein 212448..212993 Escherichia coli HS 5593990 YP_001456975.1 CDS EcHS_A0194 NC_009800.1 212990 213412 D yaeJ; identified by match to protein family HMM PF00472; peptidyl-tRNA hydrolase domain protein 212990..213412 Escherichia coli HS 5593991 YP_001456976.1 CDS cutF NC_009800.1 213426 214136 D identified by similarity to SP:P40710; match to protein family HMM PF04170; lipoprotein involved with copper homeostasis and adhesion 213426..214136 Escherichia coli HS 5593587 YP_001456977.1 CDS EcHS_A0196 NC_009800.1 214386 215366 D identified by match to protein family HMM PF01548; match to protein family HMM PF02371; IS621, transposase 214386..215366 Escherichia coli HS 5593588 YP_001456978.1 CDS EcHS_A0197 NC_009800.1 215570 216394 R yaeF; identified by similarity to GB:ABB60443.1; hypothetical protein complement(215570..216394) Escherichia coli HS 5593589 YP_001456979.1 CDS proS NC_009800.1 216448 218166 R catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase complement(216448..218166) Escherichia coli HS 5594828 YP_001456980.1 CDS EcHS_A0199 NC_009800.1 218278 218985 R NULL; identified by match to protein family HMM PF01980; match to protein family HMM TIGR00104; hypothetical protein complement(218278..218985) Escherichia coli HS 5594829 YP_001456981.1 CDS rcsF NC_009800.1 218982 219386 R outer membrane lipoprotein complement(218982..219386) Escherichia coli HS 5594830 YP_001456982.1 CDS metQ NC_009800.1 219504 220319 R identified by match to protein family HMM PF03180; match to protein family HMM TIGR00363; DL-methionine transporter substrate-binding subunit complement(219504..220319) Escherichia coli HS 5594003 YP_001456983.1 CDS metI NC_009800.1 220359 221012 R part of the MetNIQ methionine uptake system; DL-methionine transporter permease subunit complement(220359..221012) Escherichia coli HS 5594004 YP_001456984.1 CDS metN NC_009800.1 221005 222036 R part of the metNIQ transport system for methionine; DL-methionine transporter ATP-binding subunit complement(221005..222036) Escherichia coli HS 5594005 YP_001456985.1 CDS EcHS_A0204 NC_009800.1 222224 222796 D Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate; D,D-heptose 1,7-bisphosphate phosphatase 222224..222796 Escherichia coli HS 5591212 YP_001456986.1 CDS dkgB NC_009800.1 228545 229348 D catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; 2,5-diketo-D-gluconate reductase B 228545..229348 Escherichia coli HS 5592212 YP_001456987.1 CDS EcHS_A0212 NC_009800.1 229345 230259 R identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator complement(229345..230259) Escherichia coli HS 5594779 YP_001456988.1 CDS EcHS_A0213 NC_009800.1 230521 231300 D yafD; identified by match to protein family HMM PF03372; hypothetical protein 230521..231300 Escherichia coli HS 5594780 YP_001456989.1 CDS EcHS_A0214 NC_009800.1 231378 232148 D identified by match to protein family HMM PF01209; match to protein family HMM PF08241; match to protein family HMM PF08242; UbiE/COQ5 family methlytransferase 231378..232148 Escherichia coli HS 5595500 YP_001456990.1 CDS mltD NC_009800.1 232196 233554 R catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; may play a role in recycling muropeptides during cell division and/or cell elongation; in Helicobacter pylori MltD is a endolytic transglycosylase involved mainly in the rearrangement of the peptidoglycan layer of the bacterial cell wall; membrane-bound lytic murein transglycosylase D complement(232196..233554) Escherichia coli HS 5595501 YP_001456991.1 CDS gloB NC_009800.1 233626 234381 R catalyzes the hydrolysis of S-D-lactoylglutathione to D-lactic acid and reduced glutathione; plays an important role in cellular detoxification using glutathione; hydroxyacylglutathione hydrolase complement(233626..234381) Escherichia coli HS 5595502 YP_001456992.1 CDS EcHS_A0217 NC_009800.1 234415 235137 D yafS; identified by similarity to GB:AAV78381.1; match to protein family HMM PF08241; methyltransferase 234415..235137 Escherichia coli HS 5595503 YP_001456993.1 CDS rnhA NC_009800.1 235134 235601 R An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease H complement(235134..235601) Escherichia coli HS 5595218 YP_001456994.1 CDS dnaQ NC_009800.1 235666 236397 D 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 235666..236397 Escherichia coli HS 5595219 YP_001456995.1 CDS EcHS_A0221 NC_009800.1 236738 236887 R identified by glimmer; hypothetical protein complement(236738..236887) Escherichia coli HS 5591170 YP_001456996.1 CDS EcHS_A0222 NC_009800.1 236933 237718 D lipoprotein 236933..237718 Escherichia coli HS 5591171 YP_001456997.1 CDS EcHS_A0223 NC_009800.1 238344 239258 R yafU; identified by similarity to GB:CAH22064.1; hypothetical protein complement(238344..239258) Escherichia coli HS 5591429 YP_001456998.1 CDS EcHS_A0224 NC_009800.1 239302 239784 R identified by match to protein family HMM PF05638; match to protein family HMM TIGR03344; hypothetical protein complement(239302..239784) Escherichia coli HS 5591430 YP_001456999.1 CDS EcHS_A0225 NC_009800.1 239808 241160 R identified by similarity to GB:AAZ87018.1; match to protein family HMM PF06812; ImpA domain-containing protein complement(239808..241160) Escherichia coli HS 5591431 YP_001457000.1 CDS EcHS_A0226 NC_009800.1 241171 244695 R identified by match to protein family HMM PF06744; match to protein family HMM PF06761; match to protein family HMM TIGR03348; hypothetical protein complement(241171..244695) Escherichia coli HS 5591432 YP_001457001.1 CDS EcHS_A0227 NC_009800.1 244714 246126 R identified by match to protein family HMM PF06812; match to protein family HMM TIGR03362; ImpA domain-containing protein complement(244714..246126) Escherichia coli HS 5592202 YP_001457002.1 CDS EcHS_A0228 NC_009800.1 246131 246874 R NULL; identified by match to protein family HMM TIGR03360; type VI secretion-associated protein complement(246131..246874) Escherichia coli HS 5592203 YP_001457003.1 CDS clpV NC_009800.1 246871 249642 R identified by match to protein family HMM PF00004; match to protein family HMM PF07724; match to protein family HMM PF07728; match to protein family HMM TIGR03345; type VI secretion ATPase complement(246871..249642) Escherichia coli HS 5592204 YP_001457004.1 CDS EcHS_A0230 NC_009800.1 249651 250412 R NULL; identified by similarity to GB:AAN68224.1; match to protein family HMM TIGR03349; hypothetical protein complement(249651..250412) Escherichia coli HS 5591120 YP_001457005.1 CDS EcHS_A0231 NC_009800.1 250417 251748 R NULL; identified by similarity to GB:AAM83869.1; match to protein family HMM PF05936; match to protein family HMM TIGR03353; hypothetical protein complement(250417..251748) Escherichia coli HS 5591121 YP_001457006.1 CDS EcHS_A0232 NC_009800.1 251751 252275 R NULL; identified by match to protein family HMM TIGR03352; type VI secretion lipoprotein complement(251751..252275) Escherichia coli HS 5591122 YP_001457007.1 CDS EcHS_A0233 NC_009800.1 252272 253552 R NULL; identified by similarity to GB:CAG76339.1; match to protein family HMM TIGR03354; hypothetical protein complement(252272..253552) Escherichia coli HS 5592000 YP_001457008.1 CDS EcHS_A0234 NC_009800.1 253577 254659 R NULL; identified by similarity to GB:CAH22872.1; match to protein family HMM PF06996; match to protein family HMM TIGR03347; hypothetical protein complement(253577..254659) Escherichia coli HS 5592001 YP_001457009.1 CDS EcHS_A0235 NC_009800.1 254623 256473 R NULL; identified by similarity to GB:CAG76341.1; match to protein family HMM PF05947; match to protein family HMM TIGR03359; hypothetical protein complement(254623..256473) Escherichia coli HS 5592002 YP_001457010.1 CDS EcHS_A0236 NC_009800.1 256477 256890 R NULL; identified by similarity to GB:CAG76342.1; match to protein family HMM PF04965; match to protein family HMM TIGR03357; hypothetical protein complement(256477..256890) Escherichia coli HS 5595039 YP_001457011.1 CDS EcHS_A0237 NC_009800.1 256897 258372 R NULL; identified by similarity to GB:CAH22875.1; match to protein family HMM PF05943; match to protein family HMM TIGR03355; hypothetical protein complement(256897..258372) Escherichia coli HS 5595040 YP_001457012.1 CDS EcHS_A0238 NC_009800.1 258423 258647 R NULL; identified by glimmer; hypothetical protein complement(258423..258647) Escherichia coli HS 5595041 YP_001457013.1 CDS EcHS_A0239 NC_009800.1 258682 259182 R NULL; identified by similarity to GB:CAH22876.1; match to protein family HMM PF05591; match to protein family HMM TIGR03358; hypothetical protein complement(258682..259182) Escherichia coli HS 5592164 YP_001457014.1 CDS EcHS_A0240 NC_009800.1 259609 259752 D NULL; identified by glimmer; hypothetical protein 259609..259752 Escherichia coli HS 5592165 YP_001457015.1 CDS EcHS_A0241 NC_009800.1 259879 260397 D NULL; identified by match to protein family HMM PF05638; match to protein family HMM TIGR03344; hypothetical protein 259879..260397 Escherichia coli HS 5592166 YP_001457016.1 CDS EcHS_A0242 NC_009800.1 260430 260567 D identified by glimmer; hypothetical protein 260430..260567 Escherichia coli HS 5591180 YP_001457017.1 CDS EcHS_A0243 NC_009800.1 260607 262748 D identified by match to protein family HMM PF04524; match to protein family HMM PF06715; match to protein family HMM TIGR01646; match to protein family HMM TIGR03361; type VI secretion system Vgr family protein 260607..262748 Escherichia coli HS 5591181 YP_001457018.1 CDS rhsH NC_009800.1 262824 267077 D identified by similarity to GB:AAC32471.1; match to protein family HMM PF03527; match to protein family HMM PF05593; match to protein family HMM TIGR01643; protein RhsH 262824..267077 Escherichia coli HS 5591182 YP_001457019.1 CDS EcHS_A0245 NC_009800.1 267089 267538 D identified by glimmer; hypothetical protein 267089..267538 Escherichia coli HS 5595200 YP_001457020.1 CDS EcHS_A0247 NC_009800.1 268977 269747 R identified by match to protein family HMM PF00795; hypothetical protein complement(268977..269747) Escherichia coli HS 5595202 YP_001457021.1 CDS EcHS_A0248 NC_009800.1 269901 270374 D inactivates vertebrate C-type lysozyme; C-lysozyme inhibitor 269901..270374 Escherichia coli HS 5595233 YP_001457022.1 CDS fadE NC_009800.1 270417 272861 R functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA; acyl-CoA dehydrogenase complement(270417..272861) Escherichia coli HS 5595234 YP_001457023.1 CDS gmhA NC_009800.1 273101 273679 D catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate; phosphoheptose isomerase 273101..273679 Escherichia coli HS 5595235 YP_001457024.1 CDS EcHS_A0251 NC_009800.1 273885 274652 D identified by match to protein family HMM PF00310; glutamine amidotransferase, class II 273885..274652 Escherichia coli HS 5593855 YP_001457025.1 CDS EcHS_A0252 NC_009800.1 274623 275363 R yafK; identified by match to protein family HMM PF06104; hypothetical protein complement(274623..275363) Escherichia coli HS 5593856 YP_001457026.1 CDS EcHS_A0253 NC_009800.1 275519 275797 R yafQ; identified by similarity to GB:AAZ87051.1; match to protein family HMM PF05016; match to protein family HMM TIGR00053; match to protein family HMM TIGR02385; hypothetical protein complement(275519..275797) Escherichia coli HS 5593857 YP_001457027.1 CDS EcHS_A0254 NC_009800.1 275800 276060 R identified by match to protein family HMM PF04221; match to protein family HMM TIGR02384; addiction module antitoxin complement(275800..276060) Escherichia coli HS 5594355 YP_001457028.1 CDS EcHS_A0255 NC_009800.1 276210 277019 D identified by match to protein family HMM PF00877; NlpC/P60 family protein 276210..277019 Escherichia coli HS 5594356 YP_001457029.1 CDS EcHS_A0256 NC_009800.1 277076 277432 R identified by match to protein family HMM PF05534; HicB family protein complement(277076..277432) Escherichia coli HS 5594357 YP_001457030.1 CDS EcHS_A0257 NC_009800.1 277425 277703 R identified by similarity to GB:CAE13002.1; hypothetical protein complement(277425..277703) Escherichia coli HS 5591514 YP_001457031.1 CDS EcHS_A0259 NC_009800.1 277808 279547 R identified by match to protein family HMM PF00771; FHIPEP family type III secretion protein complement(277808..279547) Escherichia coli HS 5591515 YP_001457032.1 CDS EcHS_A0258 NC_009800.1 279507 280277 D identified by match to protein family HMM PF00691; hypothetical protein 279507..280277 Escherichia coli HS 5591516 YP_001457033.1 CDS dinB NC_009800.1 280348 281403 D involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 280348..281403 Escherichia coli HS 5593539 YP_001457034.1 CDS EcHS_A0261 NC_009800.1 281400 281852 D identified by match to protein family HMM PF00583; hypothetical protein 281400..281852 Escherichia coli HS 5593540 YP_001457035.1 CDS EcHS_A0262 NC_009800.1 282071 283237 D mutations in this gene result in a compromised ability for drug-inducible mexXY expression; expression is inducible by the same ribosome-targeting agents that induce mexXY; hypothetical protein 282071..283237 Escherichia coli HS 5593541 YP_001457036.1 CDS prfH NC_009800.1 283234 283848 D similar to release factor 1 and 2; peptide chain release factor-like protein 283234..283848 Escherichia coli HS 5592185 YP_001457037.1 CDS pepD NC_009800.1 283905 285362 R identified by similarity to SP:P15288; match to protein family HMM PF01546; match to protein family HMM PF07687; match to protein family HMM TIGR01893; aminoacyl-histidine dipeptidase complement(283905..285362) Escherichia coli HS 5592186 YP_001457038.1 CDS gpt NC_009800.1 285623 286081 D catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively; xanthine-guanine phosphoribosyltransferase 285623..286081 Escherichia coli HS 5592187 YP_001457039.1 CDS frsA NC_009800.1 286173 287417 D forms a 1:1 complex with the unphosphorylated from of enzyme IIAGlc; FrsA may promote fermentation; fermentation/respiration switch protein 286173..287417 Escherichia coli HS 5592275 YP_001457040.1 CDS crl NC_009800.1 287475 287876 D involved in the expression of csgBA which is involved in curli formation; interacts with sigmaS; DNA-binding transcriptional regulator Crl 287475..287876 Escherichia coli HS 5592276 YP_001457041.1 CDS phoE NC_009800.1 287915 288970 R identified by similarity to SP:P02932; match to protein family HMM PF00267; match to protein family HMM TIGR03304; outer membrane phosphoporin protein E complement(287915..288970) Escherichia coli HS 5592277 YP_001457042.1 CDS proB NC_009800.1 289258 290361 D catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 289258..290361 Escherichia coli HS 5593207 YP_001457043.1 CDS proA NC_009800.1 290373 291626 D Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 290373..291626 Escherichia coli HS 5593208 YP_001457044.1 CDS EcHS_A0272 NC_009800.1 291831 292991 R identified by match to protein family HMM PF00589; phage integrase site specific recombinase complement(291831..292991) Escherichia coli HS 5594619 YP_001457045.1 CDS EcHS_A0273 NC_009800.1 293301 293645 R lipoprotein complement(293301..293645) Escherichia coli HS 5594620 YP_001457046.1 CDS EcHS_A0274 NC_009800.1 293833 294474 R identified by match to protein family HMM PF04447; match to protein family HMM PF04448; hypothetical protein complement(293833..294474) Escherichia coli HS 5591992 YP_001457047.1 CDS EcHS_A0275 NC_009800.1 294476 295159 R identified by match to protein family HMM PF04447; hypothetical protein complement(294476..295159) Escherichia coli HS 5591993 YP_001457048.1 CDS EcHS_A0276 NC_009800.1 295156 295782 R hypothetical protein complement(295156..295782) Escherichia coli HS 5591994 YP_001457049.1 CDS EcHS_A0277 NC_009800.1 295797 295964 R identified by glimmer; hypothetical protein complement(295797..295964) Escherichia coli HS 5591995 YP_001457050.1 CDS EcHS_A0278 NC_009800.1 295981 296295 R phage protein like Prophage functions; identified by glimmer; hypothetical protein complement(295981..296295) Escherichia coli HS 5592579 YP_001457051.1 CDS EcHS_A0279 NC_009800.1 296307 296666 R hypothetical protein complement(296307..296666) Escherichia coli HS 5592580 YP_001457052.1 CDS EcHS_A0280 NC_009800.1 296704 296982 D identified by match to protein family HMM PF01527; ISEhe3, transposase orfA 296704..296982 Escherichia coli HS 5592581 YP_001457053.1 CDS EcHS_A0281 NC_009800.1 297039 297851 D identified by similarity to GB:AAP17067.1; match to protein family HMM PF00665; ISEhe3, transposase orfB 297039..297851 Escherichia coli HS 5593179 YP_001457054.1 CDS EcHS_A0282 NC_009800.1 297848 298021 R Gp46 protein like similar to bacteriophage protein; hypothetical protein complement(297848..298021) Escherichia coli HS 5593180 YP_001457055.1 CDS EcHS_A0283 NC_009800.1 298005 298907 R identified by similarity to SP:P33228; match to protein family HMM PF03837; match to protein family HMM TIGR00616; RecT family protein complement(298005..298907) Escherichia coli HS 5593181 YP_001457056.1 CDS EcHS_A0284 NC_009800.1 299193 299330 R phage protein; hypothetical protein complement(299193..299330) Escherichia coli HS 5593393 YP_001457057.1 CDS EcHS_A0285 NC_009800.1 299543 299911 R identified by glimmer; hypothetical protein complement(299543..299911) Escherichia coli HS 5593394 YP_001457058.1 CDS EcHS_A0286 NC_009800.1 300094 300345 R identified by glimmer; hypothetical protein complement(300094..300345) Escherichia coli HS 5593395 YP_001457059.1 CDS EcHS_A0287 NC_009800.1 300479 300823 R identified by glimmer; hypothetical protein complement(300479..300823) Escherichia coli HS 5593307 YP_001457060.1 CDS EcHS_A0288 NC_009800.1 300820 301125 R identified by glimmer; hypothetical protein complement(300820..301125) Escherichia coli HS 5593308 YP_001457061.1 CDS c2 NC_009800.1 301440 302090 R identified by similarity to SP:P69202; match to protein family HMM PF00717; match to protein family HMM PF01381; P22 repressor protein c2 complement(301440..302090) Escherichia coli HS 5593309 YP_001457062.1 CDS cro NC_009800.1 302171 302356 D identified by similarity to SP:P09964; regulatory protein Cro 302171..302356 Escherichia coli HS 5594387 YP_001457063.1 CDS EcHS_A0291 NC_009800.1 302472 302768 D identified by match to protein family HMM PF05269; bacteriophage CII protein 302472..302768 Escherichia coli HS 5594388 YP_001457064.1 CDS EcHS_A0292 NC_009800.1 302940 303839 D identified by similarity to GB:CAC83138.1; replication protein O 302940..303839 Escherichia coli HS 5594389 YP_001457065.1 CDS EcHS_A0293 NC_009800.1 303829 305265 D identified by match to protein family HMM PF00772; match to protein family HMM PF03796; replicative DNA helicase-like protein 303829..305265 Escherichia coli HS 5590932 YP_001457066.1 CDS EcHS_A0294 NC_009800.1 305342 305782 D identified by match to protein family HMM PF05772; ninB protein 305342..305782 Escherichia coli HS 5590933 YP_001457067.1 CDS EcHS_A0295 NC_009800.1 305919 306095 D identified by match to protein family HMM PF05322; NinE-familyprotein 305919..306095 Escherichia coli HS 5590934 YP_001457068.1 CDS EcHS_A0296 NC_009800.1 306098 306457 D similar to bacteriophage P22 ninX no additional details recorded; protein ninX 306098..306457 Escherichia coli HS 5595450 YP_001457069.1 CDS EcHS_A0297 NC_009800.1 306457 306633 D identified by match to protein family HMM PF05810; hypothetical protein 306457..306633 Escherichia coli HS 5595451 YP_001457070.1 CDS EcHS_A0298 NC_009800.1 306626 306895 D hypothetical protein 306626..306895 Escherichia coli HS 5595452 YP_001457071.1 CDS EcHS_A0299 NC_009800.1 306895 307185 D identified by match to protein family HMM PF07102; hypothetical protein 306895..307185 Escherichia coli HS 5591195 YP_001457072.1 CDS rusA NC_009800.1 307182 307544 D identified by similarity to SP:Q9MCN8; match to protein family HMM PF05866; crossover junction endodeoxyribonuclease RusA 307182..307544 Escherichia coli HS 5591196 YP_001457073.1 CDS EcHS_A0301 NC_009800.1 307541 307729 D identified by match to protein family HMM PF06322; phage NinH protein 307541..307729 Escherichia coli HS 5591197 YP_001457074.1 CDS EcHS_A0302 NC_009800.1 307726 308349 D identified by similarity to SP:P03047; match to protein family HMM PF03589; antitermination protein Q 307726..308349 Escherichia coli HS 5592495 YP_001457075.1 CDS EcHS_A0303 NC_009800.1 309172 309495 D identified by match to protein family HMM PF05106; match to protein family HMM TIGR01594; phage holin 309172..309495 Escherichia coli HS 5592496 YP_001457076.1 CDS EcHS_A0304 NC_009800.1 309479 309955 D identified by match to protein family HMM PF00959; phage lysozyme 309479..309955 Escherichia coli HS 5592497 YP_001457077.1 CDS EcHS_A0305 NC_009800.1 309952 310389 D identified by match to protein family HMM PF03245; bacteriophage lysis protein 309952..310389 Escherichia coli HS 5591561 YP_001457078.1 CDS EcHS_A0306 NC_009800.1 310553 311107 D identified by match to protein family HMM TIGR02681; Rha family phage regulatory protein 310553..311107 Escherichia coli HS 5591562 YP_001457079.1 CDS EcHS_A0307 NC_009800.1 311462 311704 D hypothetical protein 311462..311704 Escherichia coli HS 5591563 YP_001457080.1 CDS EcHS_A0308 NC_009800.1 311707 312147 D hypothetical protein 311707..312147 Escherichia coli HS 5593466 YP_001457081.1 CDS EcHS_A0309 NC_009800.1 312144 313559 D identified by match to protein family HMM PF04466; match to protein family HMM PF07570; match to protein family HMM TIGR01547; PBSX family phage terminase large subunit 312144..313559 Escherichia coli HS 5593467 YP_001457082.1 CDS EcHS_A0310 NC_009800.1 313576 315759 D portal protein-like; hypothetical protein 313576..315759 Escherichia coli HS 5593468 YP_001457083.1 CDS EcHS_A0311 NC_009800.1 315850 316743 D identified by glimmer; hypothetical protein 315850..316743 Escherichia coli HS 5590967 YP_001457084.1 CDS EcHS_A0312 NC_009800.1 316762 318015 D coat protein-like; identified by glimmer; hypothetical protein 316762..318015 Escherichia coli HS 5590968 YP_001457085.1 CDS EcHS_A0313 NC_009800.1 318021 318245 D hypothetical protein 318021..318245 Escherichia coli HS 5590969 YP_001457086.1 CDS EcHS_A0314 NC_009800.1 318226 318687 D hypothetical protein 318226..318687 Escherichia coli HS 5592755 YP_001457087.1 CDS EcHS_A0315 NC_009800.1 318697 320115 D DNA stabilization protein 318697..320115 Escherichia coli HS 5592756 YP_001457088.1 CDS EcHS_A0316 NC_009800.1 320115 321068 D hypothetical protein 320115..321068 Escherichia coli HS 5592757 YP_001457089.1 CDS EcHS_A0317 NC_009800.1 321068 321523 D hypothetical protein 321068..321523 Escherichia coli HS 5594070 YP_001457090.1 CDS EcHS_A0318 NC_009800.1 321526 322218 D identified by similarity to SP:Q9AYZ1; DNA transfer protein 321526..322218 Escherichia coli HS 5594071 YP_001457091.1 CDS EcHS_A0319 NC_009800.1 322229 323614 D identified by similarity to SP:Q01076; DNA transfer protein 322229..323614 Escherichia coli HS 5594072 YP_001457092.1 CDS EcHS_A0320 NC_009800.1 323614 325440 D identified by similarity to GB:AAX64270.1; injection protein 323614..325440 Escherichia coli HS 5594616 YP_001457093.1 CDS EcHS_A0321 NC_009800.1 325462 326133 R identified by glimmer; hypothetical protein complement(325462..326133) Escherichia coli HS 5594617 YP_001457094.1 CDS EcHS_A0322 NC_009800.1 326165 326806 R identified by similarity to SP:P69202; match to protein family HMM PF00717; match to protein family HMM PF01381; helix-turn-helix/peptidase S24-like domain-containing protein complement(326165..326806) Escherichia coli HS 5594618 YP_001457095.1 CDS EcHS_A0323 NC_009800.1 327153 327779 D hypothetical protein 327153..327779 Escherichia coli HS 5592690 YP_001457096.1 CDS EcHS_A0324 NC_009800.1 327868 328461 D hypothetical protein 327868..328461 Escherichia coli HS 5592691 YP_001457097.1 CDS EcHS_A0325 NC_009800.1 328522 328800 D identified by match to protein family HMM PF01527; ISEhe3, transposase orfA 328522..328800 Escherichia coli HS 5592692 YP_001457098.1 CDS EcHS_A0326 NC_009800.1 328857 329669 D identified by similarity to GB:AAP17067.1; match to protein family HMM PF00665; ISEhe3, transposase orfB 328857..329669 Escherichia coli HS 5591627 YP_001457099.1 CDS EcHS_A0327 NC_009800.1 330240 332150 D bifunctional tail protein-like; identified by match to protein family HMM PF09008; hypothetical protein 330240..332150 Escherichia coli HS 5591628 YP_001457100.1 CDS EcHS_A0328 NC_009800.1 332857 333174 D protein UmuD-like; hypothetical protein 332857..333174 Escherichia coli HS 5591629 YP_001457101.1 CDS EcHS_A0329 NC_009800.1 333837 335045 D identified by match to protein family HMM PF00589; site-specific recombinase, phage integrase 333837..335045 Escherichia coli HS 5590906 YP_001457102.1 CDS EcHS_A0330 NC_009800.1 335287 336495 D identified by match to protein family HMM PF02384; DNA methylase 335287..336495 Escherichia coli HS 5590907 YP_001457103.1 CDS EcHS_A0331 NC_009800.1 336488 338194 D hypothetical protein 336488..338194 Escherichia coli HS 5590908 YP_001457104.1 CDS EcHS_A0332 NC_009800.1 338139 339242 D identified by glimmer; hypothetical protein 338139..339242 Escherichia coli HS 5591047 YP_001457105.1 CDS EcHS_A0333 NC_009800.1 339443 339946 R identified by match to protein family HMM PF03400; IS1, transposase orfB complement(339443..339946) Escherichia coli HS 5591048 YP_001457106.1 CDS EcHS_A0335 NC_009800.1 340169 340483 R identified by glimmer; hypothetical protein complement(340169..340483) Escherichia coli HS 5591049 YP_001457107.1 CDS EcHS_A0336 NC_009800.1 340859 341500 D identified by similarity to GB:AAM08040.1; match to protein family HMM PF08849; hypothetical protein 340859..341500 Escherichia coli HS 5592368 YP_001457108.1 CDS EcHS_A0337 NC_009800.1 341497 342099 D identified by match to protein family HMM PF08747; hypothetical protein 341497..342099 Escherichia coli HS 5592369 YP_001457109.1 CDS EcHS_A0338 NC_009800.1 342111 345752 D hypothetical protein 342111..345752 Escherichia coli HS 5592370 YP_001457110.1 CDS EcHS_A0339 NC_009800.1 345798 349415 D identified by similarity to GB:AAL23313.1; restriction enzyme 345798..349415 Escherichia coli HS 5595008 YP_001457111.1 CDS EcHS_A0340 NC_009800.1 349592 352189 D identified by match to protein family HMM PF08665; match to protein family HMM TIGR02687; hypothetical protein 349592..352189 Escherichia coli HS 5595009 YP_001457112.1 CDS EcHS_A0341 NC_009800.1 352200 354284 D identified by match to protein family HMM TIGR02653; match to protein family HMM TIGR02688; hypothetical protein 352200..354284 Escherichia coli HS 5595010 YP_001457113.1 CDS EcHS_A0342 NC_009800.1 354549 354974 R identified by glimmer; hypothetical protein complement(354549..354974) Escherichia coli HS 5592561 YP_001457114.1 CDS EcHS_A0343 NC_009800.1 354971 355354 R identified by similarity to GB:CAG75764.1; hypothetical protein complement(354971..355354) Escherichia coli HS 5592562 YP_001457115.1 CDS EcHS_A0344 NC_009800.1 355623 355739 R identified by glimmer; hypothetical protein complement(355623..355739) Escherichia coli HS 5592563 YP_001457116.1 CDS EcHS_A0345 NC_009800.1 355726 356325 R identified by glimmer; hypothetical protein complement(355726..356325) Escherichia coli HS 5592402 YP_001457117.1 CDS EcHS_A0346 NC_009800.1 356879 357157 D identified by match to protein family HMM PF01527; ISEhe3, transposase orfA 356879..357157 Escherichia coli HS 5592403 YP_001457118.1 CDS EcHS_A0347 NC_009800.1 357214 358026 D identified by similarity to GB:AAP17067.1; match to protein family HMM PF00665; ISEhe3, transposase orfB 357214..358026 Escherichia coli HS 5592404 YP_001457119.1 CDS matA NC_009800.1 358203 358793 R identified by match to protein family HMM PF00196; fimbrillin MatA complement(358203..358793) Escherichia coli HS 5591239 YP_001457120.1 CDS rpmJ NC_009800.1 359830 359970 R smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif; 50S ribosomal protein L36 complement(359830..359970) Escherichia coli HS 5591240 YP_001457121.1 CDS rpmE2 NC_009800.1 359970 360233 R RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 complement(359970..360233) Escherichia coli HS 5591241 YP_001457122.1 CDS EcHS_A0351 NC_009800.1 361814 366067 D identified by similarity to SP:P36943; match to protein family HMM PF02369; intimin 361814..366067 Escherichia coli HS 5594736 YP_001457123.1 CDS EcHS_A0352 NC_009800.1 366188 367045 R identified by match to protein family HMM PF00165; match to protein family HMM PF06445; AraC family transcriptional regulator complement(366188..367045) Escherichia coli HS 5594737 YP_001457124.1 CDS EcHS_A0353 NC_009800.1 367294 368163 D identified by match to protein family HMM PF00248; aldo/keto reductase 367294..368163 Escherichia coli HS 5594738 YP_001457125.1 CDS EcHS_A0355 NC_009800.1 368323 368916 R ykgB; identified by match to protein family HMM PF04224; hypothetical protein complement(368323..368916) Escherichia coli HS 5592567 YP_001457127.1 CDS EcHS_A0356 NC_009800.1 369273 370598 R Involved in disulfide oxidoreductase activity and electron transport; pyridine nucleotide-disulfide oxidoreductase complement(369273..370598) Escherichia coli HS 5592569 YP_001457128.1 CDS EcHS_A0357 NC_009800.1 370678 370770 D identified by glimmer; hypothetical protein 370678..370770 Escherichia coli HS 5593343 YP_001457129.1 CDS EcHS_A0358 NC_009800.1 370824 371678 D identified by match to protein family HMM PF00165; AraC family transcriptional regulator 370824..371678 Escherichia coli HS 5593344 YP_001457130.1 CDS EcHS_A0359 NC_009800.1 372205 372924 D identified by match to protein family HMM PF02754; hypothetical protein 372205..372924 Escherichia coli HS 5593345 YP_001457131.1 CDS EcHS_A0360 NC_009800.1 372935 374362 D identified by match to protein family HMM PF02589; match to protein family HMM TIGR00273; iron-sulfur cluster binding protein 372935..374362 Escherichia coli HS 5593038 YP_001457132.1 CDS EcHS_A0361 NC_009800.1 374355 375050 D ykgG; identified by similarity to GB:AAP15803.1; match to protein family HMM PF02589; hypothetical protein 374355..375050 Escherichia coli HS 5593039 YP_001457133.1 CDS EcHS_A0362 NC_009800.1 375293 375961 R NULL; hypothetical protein complement(375293..375961) Escherichia coli HS 5593040 YP_001457134.1 CDS EcHS_A0363 NC_009800.1 376124 378421 R NULL; identified by match to protein family HMM PF03797; match to protein family HMM TIGR01414; outer membrane autotransporter complement(376124..378421) Escherichia coli HS 5592457 YP_001457135.1 CDS EcHS_A0364 NC_009800.1 378463 379224 R hypothetical protein complement(378463..379224) Escherichia coli HS 5592458 YP_001457136.1 CDS EcHS_A0365 NC_009800.1 379378 380172 R identified by match to protein family HMM PF00196; HTH DNA-binding domain-containing protein complement(379378..380172) Escherichia coli HS 5592459 YP_001457137.1 CDS EcHS_A0366 NC_009800.1 380502 381023 R identified by match to protein family HMM PF00589; phage integrase site specific recombinase complement(380502..381023) Escherichia coli HS 5594413 YP_001457138.1 CDS EcHS_A0367 NC_009800.1 381470 381745 R identified by match to protein family HMM PF03811; IS1, transposase orfA complement(381470..381745) Escherichia coli HS 5594414 YP_001457139.1 CDS EcHS_A0368 NC_009800.1 382383 382478 D identified by glimmer; hypothetical protein 382383..382478 Escherichia coli HS 5594415 YP_001457140.1 CDS EcHS_A0369 NC_009800.1 382647 382898 D NULL; identified by glimmer; hypothetical protein 382647..382898 Escherichia coli HS 5592814 YP_001457141.1 CDS betA NC_009800.1 382917 384587 R catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine; choline dehydrogenase complement(382917..384587) Escherichia coli HS 5592815 YP_001457142.1 CDS betB NC_009800.1 384601 386073 R catalyzes the formation of betaine from betaine aldehyde; betaine aldehyde dehydrogenase complement(384601..386073) Escherichia coli HS 5592816 YP_001457143.1 CDS betI NC_009800.1 386087 386674 R HTH-type; bet1; Repressor involved in choline regulation of the bet genes; transcriptional regulator BetI complement(386087..386674) Escherichia coli HS 5591499 YP_001457144.1 CDS betT NC_009800.1 386803 388836 D proton-motive-force-driven choline transporter; choline transport protein BetT 386803..388836 Escherichia coli HS 5591500 YP_001457145.1 CDS EcHS_A0374 NC_009800.1 389409 393392 D identified by match to protein family HMM PF03212; match to protein family HMM PF03797; match to protein family HMM TIGR01414; match to protein family HMM TIGR03304; outer membrane autotransporter 389409..393392 Escherichia coli HS 5591501 YP_001457146.1 CDS EcHS_A0375 NC_009800.1 393534 394622 D identified by match to protein family HMM PF00196; match to protein family HMM PF00563; LuxR family transcriptional regulator 393534..394622 Escherichia coli HS 5591736 YP_001457147.1 CDS EcHS_A0376 NC_009800.1 394664 395596 R NULL; identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator complement(394664..395596) Escherichia coli HS 5591737 YP_001457148.1 CDS EcHS_A0377 NC_009800.1 395688 396185 R NULL; identified by similarity to SP:P77219; match to protein family HMM PF06496; hypothetical protein complement(395688..396185) Escherichia coli HS 5591738 YP_001457149.1 CDS EcHS_A0378 NC_009800.1 396262 396495 D identified by similarity to GB:AAN78919.1; hypothetical protein 396262..396495 Escherichia coli HS 5594046 YP_001457150.1 CDS EcHS_A0379 NC_009800.1 396443 397048 D identified by match to protein family HMM PF00023; ankyrin repeat-containing protein 396443..397048 Escherichia coli HS 5594047 YP_001457151.1 CDS EcHS_A0380 NC_009800.1 397088 397951 D yahE; identified by similarity to GB:AAZ87092.1; hypothetical protein 397088..397951 Escherichia coli HS 5594048 YP_001457152.1 CDS EcHS_A0381 NC_009800.1 397941 399488 D identified by match to protein family HMM PF06263; acyl-CoA synthetase 397941..399488 Escherichia coli HS 5592223 YP_001457153.1 CDS EcHS_A0382 NC_009800.1 399488 400906 D yahG; identified by match to protein family HMM PF06545; hypothetical protein 399488..400906 Escherichia coli HS 5592224 YP_001457154.1 CDS EcHS_A0383 NC_009800.1 401049 401999 D yahI; identified by match to protein family HMM PF00696; carbamate kinase 401049..401999 Escherichia coli HS 5592225 YP_001457155.1 CDS EcHS_A0384 NC_009800.1 402147 403391 D identified by match to protein family HMM PF07969; deaminase 402147..403391 Escherichia coli HS 5594991 YP_001457156.1 CDS EcHS_A0385 NC_009800.1 403659 404099 D NULL; identified by match to protein family HMM PF06171; hypothetical protein 403659..404099 Escherichia coli HS 5594992 YP_001457157.1 CDS EcHS_A0386 NC_009800.1 404353 405336 D sugar ABC transporter periplasmic sugar-binding protein 404353..405336 Escherichia coli HS 5594993 YP_001457158.1 CDS EcHS_A0387 NC_009800.1 405385 406869 D identified by match to protein family HMM PF00005; sugar ABC transporter ATP-binding protein 405385..406869 Escherichia coli HS 5593106 YP_001457159.1 CDS EcHS_A0388 NC_009800.1 406862 407833 D identified by match to protein family HMM PF02653; sugar ABC transporter permease 406862..407833 Escherichia coli HS 5593107 YP_001457160.1 CDS EcHS_A0389 NC_009800.1 407830 408786 D identified by match to protein family HMM PF02653; sugar ABC transporter permease 407830..408786 Escherichia coli HS 5593108 YP_001457161.1 CDS EcHS_A0390 NC_009800.1 408873 409922 D identified by match to protein family HMM PF00107; match to protein family HMM PF08240; zinc-binding dehydrogenase oxidoreductase 408873..409922 Escherichia coli HS 5595265 YP_001457162.1 CDS EcHS_A0391 NC_009800.1 410165 410980 D yahL; identified by similarity to GB:AAZ87085.1; hypothetical protein 410165..410980 Escherichia coli HS 5595266 YP_001457163.1 CDS EcHS_A0393 NC_009800.1 411497 411637 D NULL; identified by glimmer; hypothetical protein 411497..411637 Escherichia coli HS 5593737 YP_001457164.1 CDS EcHS_A0394 NC_009800.1 411654 412322 R yahN; identified by match to protein family HMM PF01810; match to protein family HMM TIGR00949; homoserine/threonine efflux protein complement(411654..412322) Escherichia coli HS 5593738 YP_001457165.1 CDS EcHS_A0395 NC_009800.1 412472 412747 D yahO; identified by match to protein family HMM PF07338; hypothetical protein 412472..412747 Escherichia coli HS 5593739 YP_001457166.1 CDS prpR NC_009800.1 412848 414434 R identified by match to protein family HMM PF00158; match to protein family HMM PF02954; match to protein family HMM PF06506; match to protein family HMM TIGR02329; propionate catabolism operon regulatory protein PrpR complement(412848..414434) Escherichia coli HS 5591597 YP_001457167.1 CDS prpB NC_009800.1 414673 415563 D catalyzes the formation of pyruvate and succinate from 2-methylisocitrate; 2-methylisocitrate lyase 414673..415563 Escherichia coli HS 5591598 YP_001457168.1 CDS prpC NC_009800.1 415608 416777 D catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity; methylcitrate synthase 415608..416777 Escherichia coli HS 5591599 YP_001457169.1 CDS prpD NC_009800.1 416811 418262 D functions in propionate metabolism; involved in isomerization of (2S,3S)-methylcitrate to (2R,3S)-methylisocitrate; also encodes minor aconitase or dehydratase activity; aconitase C; 2-methylcitrate dehydratase 416811..418262 Escherichia coli HS 5595152 YP_001457170.1 CDS prpE NC_009800.1 418302 420188 D catalyzes the formation of propionyl-CoA using propionate as a substrate; PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A; not expressed in Escherichia coli when grown on propionate/minimal media; ATP-dependent; propionyl-CoA synthetase 418302..420188 Escherichia coli HS 5595153 YP_001457171.1 CDS codB NC_009800.1 420425 421684 D identified by match to protein family HMM PF02133; match to protein family HMM TIGR00800; cytosine permease 420425..421684 Escherichia coli HS 5595154 YP_001457172.1 CDS codA NC_009800.1 421674 422957 D Catalyzes the deamination of cytosine to uracil and ammonia; cytosine deaminase 421674..422957 Escherichia coli HS 5594590 YP_001457173.1 CDS cynR NC_009800.1 422997 423896 R controls the expression of the cynTSX operon involved in degrading and using cyanate as a sole nitrogen source; DNA-binding transcriptional regulator CynR complement(422997..423896) Escherichia coli HS 5594591 YP_001457174.1 CDS cynT NC_009800.1 424006 424665 D identified by match to protein family HMM PF00484; carbonic anhydrase 424006..424665 Escherichia coli HS 5594592 YP_001457175.1 CDS cynS NC_009800.1 424696 425166 D catalyzes the reaction of cyanate and bicarbonate to produce ammonia and carbon dioxide; cyanate hydratase 424696..425166 Escherichia coli HS 5594577 YP_001457176.1 CDS cynX NC_009800.1 425199 426353 D MFS transporter family member induced in the presence of cyanate as part of a 3 gene operon; not essential; cyanate transporter 425199..426353 Escherichia coli HS 5594578 YP_001457177.1 CDS lacY NC_009800.1 426432 427685 R lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments; galactoside permease complement(426432..427685) Escherichia coli HS 5594579 YP_001457178.1 CDS lacZ NC_009800.1 427737 430811 R forms a homotetramer; hydrolyzes lactose disaccharide to galactose and glucose; converts lactose to allolactose which is the natural inducer of the lac operon; beta-D-galactosidase complement(427737..430811) Escherichia coli HS 5593986 YP_001457179.1 CDS lacI NC_009800.1 430934 432025 R transcriptional repressor of lac operon; forms a homotetramer as a dimer of dimers; binds specific sites in lac operon resulting in DNA looping between the operators; binds allolactose as inducer; lac repressor complement(430934..432025) Escherichia coli HS 5593987 YP_001457180.1 CDS mhpR NC_009800.1 432093 433040 R activator of 3-phenylpropionic acid catabolism; DNA-binding transcriptional activator MhpR complement(432093..433040) Escherichia coli HS 5593988 YP_001457181.1 CDS mhpA NC_009800.1 433117 434781 D catalyzes the formation of 3-(2,3-dihydroxyphenyl)propionate from 3-(3-hydroxyphenyl)propionate; 3-(3-hydroxyphenyl)propionate hydroxylase 433117..434781 Escherichia coli HS 5591963 YP_001457182.1 CDS mhpB NC_009800.1 434783 435727 D catalyzes the cleavage of 3-(2,3-dihydroxyphenyl) propionate into 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate; part of the 3-phenylpropionic acid degradation pathway; member of the protocatechuate 4,5-dioxygenase; 3-(2,3-dihydroxyphenyl)propionate dioxygenase 434783..435727 Escherichia coli HS 5591964 YP_001457183.1 CDS mhpC NC_009800.1 435730 436611 D identified by similarity to SP:P77044; match to protein family HMM PF00561; 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase 435730..436611 Escherichia coli HS 5591965 YP_001457184.1 CDS mhpD NC_009800.1 436621 437430 D catalyzes the formation of 2-keto-4-hydroxypentanoic acid from 2-hydroxypentadienoic acid; 2-keto-4-pentenoate hydratase 436621..437430 Escherichia coli HS 5595036 YP_001457185.1 CDS mhpF NC_009800.1 437427 438377 D catalyzes the formation of acetyl-CoA from acetalaldehyde; acetaldehyde dehydrogenase 437427..438377 Escherichia coli HS 5595037 YP_001457186.1 CDS mhpE NC_009800.1 438374 439387 D catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate; 4-hydroxy-2-ketovalerate aldolase 438374..439387 Escherichia coli HS 5595038 YP_001457187.1 CDS EcHS_A0417 NC_009800.1 439563 440774 D identified by similarity to SP:P77589; match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM TIGR00895; 3-hydroxyphenylpropionic transporter MhpT 439563..440774 Escherichia coli HS 5593112 YP_001457188.1 CDS EcHS_A0418 NC_009800.1 440876 441415 D hypothetical protein 440876..441415 Escherichia coli HS 5593113 YP_001457189.1 CDS EcHS_A0419 NC_009800.1 441664 442644 D identified by match to protein family HMM PF01548; match to protein family HMM PF02371; IS621, transposase 441664..442644 Escherichia coli HS 5593114 YP_001457190.1 CDS fghA2 NC_009800.1 442819 443652 R identified by match to protein family HMM PF00756; match to protein family HMM TIGR02821; S-formylglutathione hydrolase complement(442819..443652) Escherichia coli HS 5594613 YP_001457191.1 CDS adhC NC_009800.1 443745 444854 R identified by match to protein family HMM PF00107; match to protein family HMM PF08240; match to protein family HMM TIGR02818; S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase complement(443745..444854) Escherichia coli HS 5594614 YP_001457192.1 CDS EcHS_A0422 NC_009800.1 444889 445164 R formaldehyde-induced negative regulator of the frmRAB operon; regulator protein FrmR complement(444889..445164) Escherichia coli HS 5594615 YP_001457193.1 CDS EcHS_A0423 NC_009800.1 445350 446123 R yaiO; identified by glimmer; hypothetical protein complement(445350..446123) Escherichia coli HS 5595104 YP_001457194.1 CDS EcHS_A0424 NC_009800.1 446125 446565 R identified by match to protein family HMM PF00132; acyltransferase complement(446125..446565) Escherichia coli HS 5595105 YP_001457195.1 CDS EcHS_A0425 NC_009800.1 446684 447880 R yaiP; identified by match to protein family HMM PF00535; glycosyl transferase, group 2 family protein complement(446684..447880) Escherichia coli HS 5595106 YP_001457196.1 CDS EcHS_A0426 NC_009800.1 447890 448561 R yaiS; identified by match to protein family HMM PF02585; GlcNAc-PI de-N-acetylase complement(447890..448561) Escherichia coli HS 5593686 YP_001457197.1 CDS EcHS_A0427 NC_009800.1 448733 448840 D identified by glimmer; hypothetical protein 448733..448840 Escherichia coli HS 5593687 YP_001457198.1 CDS EcHS_A0429 NC_009800.1 448999 449223 R identified by similarity to GB:AAN78949.1; hypothetical protein complement(448999..449223) Escherichia coli HS 5593688 YP_001457199.1 CDS tauA NC_009800.1 449177 450139 D with TauB and TauC is responsible for taurine uptake.; taurine transporter substrate binding subunit 449177..450139 Escherichia coli HS 5591554 YP_001457200.1 CDS tauB NC_009800.1 450152 450919 D Part of the ABC transporter complex tauABC involved in taurine import; taurine transporter ATP-binding subunit 450152..450919 Escherichia coli HS 5591555 YP_001457201.1 CDS tauC NC_009800.1 450916 451743 D identified by match to protein family HMM PF00528; taurine transporter subunit 450916..451743 Escherichia coli HS 5591556 YP_001457202.1 CDS tauD NC_009800.1 451740 452591 D catalyzes the conversion of taurine (2-aminoethanesulfonate) to sulfite and aminoacetaldehyde concurrently with the conversion of alpha-ketoglutarate to succinate and carbon dioxide; non-heme iron oxidase; allows the use of taurine as an alternative sulfur source; forms homodimers; taurine dioxygenase 451740..452591 Escherichia coli HS 5591838 YP_001457203.1 CDS hemB NC_009800.1 452697 453671 R catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase complement(452697..453671) Escherichia coli HS 5591839 YP_001457204.1 CDS EcHS_A0434 NC_009800.1 454195 455721 D hypothetical protein 454195..455721 Escherichia coli HS 5591840 YP_001457205.1 CDS EcHS_A0435 NC_009800.1 455718 456530 R identified by similarity to GB:AAP17067.1; match to protein family HMM PF00665; ISEhe3, transposase orfB complement(455718..456530) Escherichia coli HS 5593252 YP_001457206.1 CDS EcHS_A0436 NC_009800.1 456587 456865 R identified by match to protein family HMM PF01527; ISEhe3, transposase orfA complement(456587..456865) Escherichia coli HS 5593253 YP_001457207.1 CDS EcHS_A0437 NC_009800.1 456918 458315 D identified by match to protein family HMM PF03797; match to protein family HMM TIGR01414; match to protein family HMM TIGR03304; outer membrane autotransporter 456918..458315 Escherichia coli HS 5593254 YP_001457208.1 CDS EcHS_A0438 NC_009800.1 458403 459026 D yaiV; identified by glimmer; DNA-binding transcriptional regulator 458403..459026 Escherichia coli HS 5591679 YP_001457209.1 CDS ampH NC_009800.1 459027 460184 R this protein has no known enzymatic function; beta-lactam binding protein AmpH complement(459027..460184) Escherichia coli HS 5591680 YP_001457210.1 CDS EcHS_A0441 NC_009800.1 460230 460331 R identified by glimmer; hypothetical protein complement(460230..460331) Escherichia coli HS 5591681 YP_001457211.1 CDS EcHS_A0440 NC_009800.1 460322 460516 D identified by glimmer; hypothetical protein 460322..460516 Escherichia coli HS 5593530 YP_001457212.1 CDS smbA NC_009800.1 460536 461756 D in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope; transport protein 460536..461756 Escherichia coli HS 5593531 YP_001457213.1 CDS EcHS_A0443 NC_009800.1 461769 462863 D yaiW; identified by match to protein family HMM PF07759; lipoprotein 461769..462863 Escherichia coli HS 5593532 YP_001457214.1 CDS EcHS_A0444 NC_009800.1 462922 463230 R yaiY; identified by similarity to SP:P0AAP7; hypothetical protein complement(462922..463230) Escherichia coli HS 5592746 YP_001457215.1 CDS EcHS_A0446 NC_009800.1 463358 463702 D yaiZ; identified by similarity to GB:AAZ87131.1; similarity to GB:CAD08834.1; hypothetical protein 463358..463702 Escherichia coli HS 5592747 YP_001457216.1 CDS ddl NC_009800.1 463726 464820 R D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A complement(463726..464820) Escherichia coli HS 5592748 YP_001457217.1 CDS EcHS_A0448 NC_009800.1 464898 465101 D identified by glimmer; hypothetical protein 464898..465101 Escherichia coli HS 5591908 YP_001457218.1 CDS EcHS_A0449 NC_009800.1 465124 465237 D identified by glimmer; hypothetical protein 465124..465237 Escherichia coli HS 5591909 YP_001457219.1 CDS EcHS_A0450 NC_009800.1 465283 465543 D yaiB; hypothetical protein 465283..465543 Escherichia coli HS 5591910 YP_001457220.1 CDS phoA NC_009800.1 465644 467059 D identified by similarity to SP:P00634; match to protein family HMM PF00245; alkaline phosphatase 465644..467059 Escherichia coli HS 5595224 YP_001457221.1 CDS psiF NC_009800.1 467178 467498 D identified by similarity to SP:P27295; match to protein family HMM PF07769; hypothetical protein 467178..467498 Escherichia coli HS 5595225 YP_001457222.1 CDS adrA NC_009800.1 467600 468715 D catalyzes the conversion of 2 GTP into c-di-GMP; adrA overexpression induces cellulose biosynthesis, cell adherence to abiotic surfaces and swimming and swarming motility; AdrA acts post-transcriptionally on the bcsABZC operon activating cellulose biosynthesis; diguanylate cyclase AdrA 467600..468715 Escherichia coli HS 5595226 YP_001457223.1 CDS proC NC_009800.1 468732 469541 R catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase complement(468732..469541) Escherichia coli HS 5591905 YP_001457224.1 CDS EcHS_A0455 NC_009800.1 469661 470119 D identified by similarity to SP:Q3Z523; match to protein family HMM PF02639; hypothetical protein 469661..470119 Escherichia coli HS 5591906 YP_001457225.1 CDS aroL NC_009800.1 470302 470826 D type II enzyme similar to type I but differentially regulated and with a lower Km; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase II 470302..470826 Escherichia coli HS 5591907 YP_001457226.1 CDS EcHS_A0457 NC_009800.1 470876 471067 D yaiA; hypothetical protein 470876..471067 Escherichia coli HS 5593258 YP_001457227.1 CDS aroM NC_009800.1 471325 472002 D identified by similarity to SP:P08403; match to protein family HMM PF07302; hypothetical protein 471325..472002 Escherichia coli HS 5593259 YP_001457228.1 CDS EcHS_A0460 NC_009800.1 472566 472847 D ykiA; identified by glimmer; hypothetical protein 472566..472847 Escherichia coli HS 5593649 YP_001457229.1 CDS rdgC NC_009800.1 473005 473916 R Required for efficient pilin antigenic variation; recombination associated protein complement(473005..473916) Escherichia coli HS 5593650 YP_001457230.1 CDS mak NC_009800.1 474041 474949 D catalyzes phosphorylation of fructose; cytosolic enzyme; fructokinase 474041..474949 Escherichia coli HS 5593651 YP_001457231.1 CDS araJ NC_009800.1 475092 476360 R member of the major facilitator superfamily (MFS) of transporters; unknown function; may be associated with transport or processing of arabinose polymers; MFS transport protein AraJ complement(475092..476360) Escherichia coli HS 5593213 YP_001457232.1 CDS sbcC NC_009800.1 476402 479545 R with SbcD cleaves DNA hairpin structures; also has 5' single-strand endonuclease activity; exonuclease SbcC complement(476402..479545) Escherichia coli HS 5593214 YP_001457233.1 CDS sbcD NC_009800.1 479542 480744 R with SbcC cleaves DNA hairpin structure, also has 5' single-strand endonuclease activity; exonuclease SbcD complement(479542..480744) Escherichia coli HS 5593215 YP_001457234.1 CDS EcHS_A0465 NC_009800.1 480730 480861 D identified by glimmer; hypothetical protein 480730..480861 Escherichia coli HS 5591676 YP_001457235.1 CDS phoB NC_009800.1 480934 481623 D two component response regulator for the phosphate regulon; PhoR phosphorylates PhoB; transcriptional regulator PhoB 480934..481623 Escherichia coli HS 5591677 YP_001457236.1 CDS phoR NC_009800.1 481681 482976 D membrane-associated histidine protein kinase that phosphorylates phoB in response to environmental signals as part of the two-component phosphate regulatory system phoR/phoB; phosphate regulon sensor protein 481681..482976 Escherichia coli HS 5591678 YP_001457237.1 CDS EcHS_A0469 NC_009800.1 482987 483097 R identified by glimmer; hypothetical protein complement(482987..483097) Escherichia coli HS 5591935 YP_001457238.1 CDS EcHS_A0470 NC_009800.1 483189 483338 R identified by similarity to GB:AAX64346.1; hypothetical protein complement(483189..483338) Escherichia coli HS 5591936 YP_001457239.1 CDS brnQ NC_009800.1 483383 484702 D identified by match to protein family HMM PF05525; match to protein family HMM TIGR00796; branched-chain amino acid transport system II carrier protein 483383..484702 Escherichia coli HS 5591937 YP_001457240.1 CDS proY NC_009800.1 484778 486151 D cryptic permease that may be involved in the transport of proline across the inner membrane; in Salmonella typhimurium, the proY gene is silent unless overexpressed on a multicopy plasmid or activated by a proZ mutation; proline-specific permease 484778..486151 Escherichia coli HS 5592827 YP_001457241.1 CDS malZ NC_009800.1 486307 488124 D identified by similarity to SP:P21517; match to protein family HMM PF00128; maltodextrin glucosidase 486307..488124 Escherichia coli HS 5592828 YP_001457242.1 CDS acpH NC_009800.1 488129 488710 R Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP; ACP phosphodieterase complement(488129..488710) Escherichia coli HS 5592829 YP_001457243.1 CDS queA NC_009800.1 488803 489873 D Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine:tRNA ribosyltransferase-isomerase 488803..489873 Escherichia coli HS 5593937 YP_001457244.1 CDS tgt NC_009800.1 489929 491056 D Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 489929..491056 Escherichia coli HS 5593938 YP_001457245.1 CDS yajC NC_009800.1 491079 491411 D member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 491079..491411 Escherichia coli HS 5593939 YP_001457246.1 CDS secD NC_009800.1 491439 493286 D part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 491439..493286 Escherichia coli HS 5592233 YP_001457247.1 CDS secF NC_009800.1 493297 494268 D forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 493297..494268 Escherichia coli HS 5592234 YP_001457248.1 CDS EcHS_A0480 NC_009800.1 494397 494744 D yajD; identified by match to protein family HMM PF01844; hypothetical protein 494397..494744 Escherichia coli HS 5592235 YP_001457249.1 CDS EcHS_A0481 NC_009800.1 494758 494880 D identified by similarity to GB:ABB67500.1; hypothetical protein 494758..494880 Escherichia coli HS 5595028 YP_001457250.1 CDS tsx NC_009800.1 494921 495805 R identified by match to protein family HMM PF03502; nucleoside-specific channel-forming protein complement(494921..495805) Escherichia coli HS 5595029 YP_001457251.1 CDS EcHS_A0483 NC_009800.1 496104 496703 R yajI; identified by similarity to GB:CAD08870.1; hypothetical protein complement(496104..496703) Escherichia coli HS 5595030 YP_001457252.1 CDS nrdR NC_009800.1 496794 497243 D identified by match to protein family HMM PF03477; match to protein family HMM TIGR00244; transcriptional regulator NrdR 496794..497243 Escherichia coli HS 5593804 YP_001457253.1 CDS ribD NC_009800.1 497247 498350 D riboflavin biosynthesis protein which catalyzes the deamination and reduction steps in the riboflavin biosynthesis pathway; catalyzes the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 5-amino-6-(5-phosphoribitylamino)uracil; bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase 497247..498350 Escherichia coli HS 5593805 YP_001457254.1 CDS ribH NC_009800.1 498439 498909 D RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 498439..498909 Escherichia coli HS 5593806 YP_001457255.1 CDS nusB NC_009800.1 498929 499348 D Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 498929..499348 Escherichia coli HS 5594309 YP_001457256.1 CDS thiL NC_009800.1 499426 500403 D catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase 499426..500403 Escherichia coli HS 5594310 YP_001457257.1 CDS pgpA NC_009800.1 500381 500899 D hydrolyzes phosphatidylglycerophosphate to produce phosphatidylglycerol and phosphate; phosphatidylglycerophosphatase A 500381..500899 Escherichia coli HS 5594311 YP_001457258.1 CDS EcHS_A0490 NC_009800.1 500953 501927 R identified by match to protein family HMM PF00248; aldo/keto reductase complement(500953..501927) Escherichia coli HS 5593090 YP_001457259.1 CDS dxs NC_009800.1 502107 503969 R catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase complement(502107..503969) Escherichia coli HS 5593091 YP_001457260.1 CDS ispA NC_009800.1 503994 504893 R identified by similarity to SP:P22939; match to protein family HMM PF00348; geranyltranstransferase complement(503994..504893) Escherichia coli HS 5593092 YP_001457261.1 CDS xseB NC_009800.1 504893 505135 R catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit complement(504893..505135) Escherichia coli HS 5595066 YP_001457262.1 CDS EcHS_A0494 NC_009800.1 505223 505315 D identified by glimmer; hypothetical protein 505223..505315 Escherichia coli HS 5595067 YP_001457263.1 CDS thiI NC_009800.1 505341 506789 D Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 505341..506789 Escherichia coli HS 5595068 YP_001457264.1 CDS thiJ NC_009800.1 506843 507433 R identified by similarity to SP:Q46948; match to protein family HMM PF01965; match to protein family HMM TIGR01383; hypothetical protein complement(506843..507433) Escherichia coli HS 5595121 YP_001457265.1 CDS panE NC_009800.1 507396 508307 R ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis; 2-dehydropantoate 2-reductase complement(507396..508307) Escherichia coli HS 5595122 YP_001457266.1 CDS EcHS_A0498 NC_009800.1 508475 508966 D nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription; nucleotide-binding protein 508475..508966 Escherichia coli HS 5595123 YP_001457267.1 CDS EcHS_A0499 NC_009800.1 509094 510458 R identified by match to protein family HMM PF07690; major facilitator transporter complement(509094..510458) Escherichia coli HS 5592966 YP_001457268.1 CDS EcHS_A0500 NC_009800.1 510806 511801 D identified by match to protein family HMM PF08238; hypothetical protein 510806..511801 Escherichia coli HS 5592967 YP_001457269.1 CDS EcHS_A0501 NC_009800.1 511857 512399 R identified by match to protein family HMM PF00583; acetyltransferase complement(511857..512399) Escherichia coli HS 5592968 YP_001457270.1 CDS EcHS_A0502 NC_009800.1 512383 512742 R identified by match to protein family HMM PF08681; hypothetical protein complement(512383..512742) Escherichia coli HS 5594148 YP_001457271.1 CDS cyoE NC_009800.1 512879 513769 R converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase complement(512879..513769) Escherichia coli HS 5594149 YP_001457272.1 CDS cyoD NC_009800.1 513781 514110 R identified by similarity to SP:P0ABJ6; match to protein family HMM PF03626; match to protein family HMM TIGR02847; cytochrome o ubiquinol oxidase subunit IV complement(513781..514110) Escherichia coli HS 5594150 YP_001457273.1 CDS cyoC NC_009800.1 514110 514724 R identified by similarity to SP:P0ABJ3; match to protein family HMM PF00510; match to protein family HMM TIGR02842; cytochrome o ubiquinol oxidase subunit III complement(514110..514724) Escherichia coli HS 5595465 YP_001457274.1 CDS cyoB NC_009800.1 514714 516705 R identified by match to protein family HMM PF00115; match to protein family HMM TIGR02843; cytochrome o ubiquinol oxidase subunit I complement(514714..516705) Escherichia coli HS 5595466 YP_001457275.1 CDS cyoA NC_009800.1 516727 517674 R identified by similarity to SP:P0ABJ1; match to protein family HMM PF00116; match to protein family HMM PF06481; match to protein family HMM TIGR01433; cytochrome o ubiquinol oxidase subunit II complement(516727..517674) Escherichia coli HS 5595467 YP_001457276.1 CDS ampG NC_009800.1 518135 519610 R in Escherichia coli this protein is a permease involved in peptidoglycan recycling; member of major facilitator superfamily; MFS; inner membrane protein; muropeptide transporter complement(518135..519610) Escherichia coli HS 5593784 YP_001457277.1 CDS EcHS_A0509 NC_009800.1 519654 520232 R identified by match to protein family HMM PF03923; hypothetical protein complement(519654..520232) Escherichia coli HS 5593785 YP_001457278.1 CDS EcHS_A0510 NC_009800.1 520282 520413 R identified by glimmer; hypothetical protein complement(520282..520413) Escherichia coli HS 5593786 YP_001457279.1 CDS EcHS_A0511 NC_009800.1 520537 520854 D positive transcriptional regulator of morphogenetic pathway; controlling several genes involved in oxidative stress, acid stress, heat shock, osmotic shock, and carbon-starvation stress; transcriptional regulator BolA 520537..520854 Escherichia coli HS 5592788 YP_001457280.1 CDS EcHS_A0512 NC_009800.1 520863 521051 D identified by glimmer; hypothetical protein 520863..521051 Escherichia coli HS 5592789 YP_001457281.1 CDS tig NC_009800.1 521198 522496 D Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 521198..522496 Escherichia coli HS 5592790 YP_001457282.1 CDS clpP NC_009800.1 522742 523365 D hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 522742..523365 Escherichia coli HS 5594181 YP_001457283.1 CDS clpX NC_009800.1 523491 524765 D binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 523491..524765 Escherichia coli HS 5594182 YP_001457284.1 CDS lon NC_009800.1 524953 527307 D identified by match to protein family HMM PF00004; match to protein family HMM PF02190; match to protein family HMM PF05362; match to protein family HMM PF07728; match to protein family HMM TIGR00763; DNA-binding ATP-dependent protease La 524953..527307 Escherichia coli HS 5594183 YP_001457285.1 CDS hupB NC_009800.1 527516 527788 D histone-like DNA-binding protein; transcriptional regulator HU subunit beta 527516..527788 Escherichia coli HS 5593584 YP_001457286.1 CDS ppiD NC_009800.1 527980 529851 D identified by similarity to SP:P0ADY1; match to protein family HMM PF00639; match to protein family HMM PF09312; peptidyl-prolyl cis-trans isomerase (rotamase D) 527980..529851 Escherichia coli HS 5593585 YP_001457287.1 CDS EcHS_A0519 NC_009800.1 530002 530373 D identified by match to protein family HMM TIGR00426; competence protein ComEA 530002..530373 Escherichia coli HS 5593586 YP_001457288.1 CDS EcHS_A0520 NC_009800.1 530467 530865 D identified by match to protein family HMM PF03061; match to protein family HMM TIGR00051; thioesterase 530467..530865 Escherichia coli HS 5591044 YP_001457289.1 CDS queC NC_009800.1 530917 531612 R YbaX; catalyzes the transformation of GTP to 7-cyano-7-deazaguanine (preQ0), as one of the early reactions of quenosine biosynthesis; quenosine is a modified nucleoside that occurs at the wobble position of GUN anticodons in tRNAs for Asn, Asp, Tyr, and His; queuosine biosynthesis protein QueC complement(530917..531612) Escherichia coli HS 5591045 YP_001457290.1 CDS EcHS_A0522 NC_009800.1 531677 533377 R identified by match to protein family HMM PF00496; solute-binding family 5 protein complement(531677..533377) Escherichia coli HS 5591046 YP_001457291.1 CDS cof NC_009800.1 533477 534295 D identified by similarity to SP:P46891; match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; hydrolase Cof 533477..534295 Escherichia coli HS 5592080 YP_001457292.1 CDS EcHS_A0524 NC_009800.1 534448 534906 D identified by match to protein family HMM PF01037; AsnC family transcriptional regulator 534448..534906 Escherichia coli HS 5592081 YP_001457293.1 CDS mdlA NC_009800.1 534936 536708 D identified by similarity to SP:P77265; match to protein family HMM PF00005; match to protein family HMM PF00664; multidrug transporter membrane\ATP-binding components 534936..536708 Escherichia coli HS 5592082 YP_001457294.1 CDS mdlB NC_009800.1 536701 538482 D identified by similarity to SP:P0AAG5; match to protein family HMM PF00005; match to protein family HMM PF00664; multidrug transporter membrane\ATP-binding components 536701..538482 Escherichia coli HS 5594298 YP_001457295.1 CDS glnK NC_009800.1 538663 539001 D indirectly regulates nitrogen metabolism; at high nitrogen levels P-II 2 prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II 2 is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; functionally it is equivalent to protein P-II (GlnB), but itsexpression is driven by the presence of uridylyltransferase, nitrogen regulator I, and the absence of ammonia.; nitrogen regulatory protein P-II 2 538663..539001 Escherichia coli HS 5594299 YP_001457296.1 CDS amt NC_009800.1 539031 540317 D identified by match to protein family HMM PF00909; match to protein family HMM TIGR00836; ammonium transporter 539031..540317 Escherichia coli HS 5594300 YP_001457297.1 CDS tesB NC_009800.1 540366 541226 R identified by match to protein family HMM PF02551; match to protein family HMM TIGR00189; acyl-CoA thioesterase complement(540366..541226) Escherichia coli HS 5594870 YP_001457298.1 CDS EcHS_A0530 NC_009800.1 541444 542016 D lipoprotein 541444..542016 Escherichia coli HS 5594871 YP_001457299.1 CDS EcHS_A0531 NC_009800.1 542047 542436 R identified by match to protein family HMM PF01035; match to protein family HMM TIGR00589; methylated-DNA-[protein]-cysteine S-methyltransferase complement(542047..542436) Escherichia coli HS 5594872 YP_001457300.1 CDS EcHS_A0532 NC_009800.1 542758 543090 D ybaA; identified by match to protein family HMM PF07237; hypothetical protein 542758..543090 Escherichia coli HS 5595443 YP_001457301.1 CDS EcHS_A0533 NC_009800.1 543132 544688 R identified by match to protein family HMM PF00563; cyclic diguanylate phosphodiesterase domain-containing protein complement(543132..544688) Escherichia coli HS 5590916 YP_001457302.1 CDS EcHS_A0534 NC_009800.1 544846 545355 R ylaC; hypothetical protein complement(544846..545355) Escherichia coli HS 5590917 YP_001457303.1 CDS maa NC_009800.1 545432 545983 R identified by similarity to SP:P77791; match to protein family HMM PF00132; maltose O-acetyltransferase complement(545432..545983) Escherichia coli HS 5590918 YP_001457304.1 CDS EcHS_A0536 NC_009800.1 546155 546373 R with Hns involved in transcriptional regulation of hemolysin; non-specific DNA-binding protein which affects the production of multiple proteins; hemolysin expression-modulating protein complement(546155..546373) Escherichia coli HS 5593023 YP_001457305.1 CDS EcHS_A0537 NC_009800.1 546399 546773 R ybaJ; identified by similarity to GB:AAV78134.1; hypothetical protein complement(546399..546773) Escherichia coli HS 5593024 YP_001457306.1 CDS EcHS_A0538 NC_009800.1 547319 550468 R identified by match to protein family HMM PF00873; match to protein family HMM TIGR00915; acriflavine resistance protein B complement(547319..550468) Escherichia coli HS 5593025 YP_001457307.1 CDS acrA NC_009800.1 550491 551684 R identified by match to protein family HMM PF00529; match to protein family HMM TIGR01730; acriflavine resistance protein A complement(550491..551684) Escherichia coli HS 5590988 YP_001457308.1 CDS acrR NC_009800.1 551826 552473 D regulates the acrAB operon which is involved in susceptibility to dephalothin and cephaloridine; DNA-binding transcriptional repressor AcrR 551826..552473 Escherichia coli HS 5590989 YP_001457309.1 CDS kefA NC_009800.1 552601 555963 D small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS; potassium efflux protein KefA 552601..555963 Escherichia coli HS 5590990 YP_001457310.1 CDS EcHS_A0542 NC_009800.1 556009 556158 D identified by glimmer; hypothetical protein 556009..556158 Escherichia coli HS 5592904 YP_001457311.1 CDS EcHS_A0543 NC_009800.1 556175 556336 R ybaM; identified by similarity to RF:NP_455077.1; hypothetical protein complement(556175..556336) Escherichia coli HS 5592905 YP_001457312.1 CDS priC NC_009800.1 556350 556877 R PriC; protein involved in DNA replication; part of the primosome, a protein complex required to restart stalled replication forks; binds the complex formed by PriA, PriB and DNA; PriC-dependent primosome requires a gap to restart DNA replication; stimulates Rep activity at stalled forks; primosomal replication protein N'' complement(556350..556877) Escherichia coli HS 5592906 YP_001457313.1 CDS EcHS_A0545 NC_009800.1 556947 557324 D identified by match to protein family HMM PF04304; hypothetical protein 556947..557324 Escherichia coli HS 5590922 YP_001457314.1 CDS apt NC_009800.1 557477 558028 D catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 557477..558028 Escherichia coli HS 5590923 YP_001457315.1 CDS dnaX NC_009800.1 558157 560088 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 558157..560088 Escherichia coli HS 5590924 YP_001457316.1 CDS EcHS_A0548 NC_009800.1 560141 560470 D ybaB; identified by similarity to GB:AAZ90762.1; match to protein family HMM PF02575; match to protein family HMM TIGR00103; hypothetical protein 560141..560470 Escherichia coli HS 5592592 YP_001457317.1 CDS recR NC_009800.1 560470 561075 D involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 560470..561075 Escherichia coli HS 5592593 YP_001457318.1 CDS htpG NC_009800.1 561185 563059 D molecular chaperone; heat shock protein 90 561185..563059 Escherichia coli HS 5592594 YP_001457319.1 CDS adk NC_009800.1 563240 563884 D essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 563240..563884 Escherichia coli HS 5591462 YP_001457320.1 CDS hemH NC_009800.1 564120 565082 D protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 564120..565082 Escherichia coli HS 5591463 YP_001457321.1 CDS aes NC_009800.1 565079 566038 R identified by similarity to SP:P23872; match to protein family HMM PF07859; acetyl esterase complement(565079..566038) Escherichia coli HS 5591464 YP_001457322.1 CDS gsk NC_009800.1 566190 567494 D identified by similarity to SP:P0AEW6; match to protein family HMM PF00294; inosine-guanosine kinase 566190..567494 Escherichia coli HS 5591386 YP_001457323.1 CDS EcHS_A0555 NC_009800.1 567627 569303 R YbaL; member of the CPA-2 family of antiporters; uncharacterized protein; cation:proton antiport protein complement(567627..569303) Escherichia coli HS 5591387 YP_001457324.1 CDS fsr NC_009800.1 569541 570761 R identified by match to protein family HMM PF07690; fosmidomycin resistance protein complement(569541..570761) Escherichia coli HS 5591388 YP_001457325.1 CDS ushA NC_009800.1 570979 572631 D catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides; bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor 570979..572631 Escherichia coli HS 5591143 YP_001457326.1 CDS EcHS_A0558 NC_009800.1 572668 573147 R identified by match to protein family HMM PF04073; match to protein family HMM TIGR00011; hypothetical protein complement(572668..573147) Escherichia coli HS 5591144 YP_001457327.1 CDS EcHS_A0559 NC_009800.1 573351 574145 R identified by match to protein family HMM PF07446; GumN family protein complement(573351..574145) Escherichia coli HS 5592601 YP_001457328.1 CDS EcHS_A0560 NC_009800.1 574229 574624 D identified by match to protein family HMM PF01381; match to protein family HMM TIGR02607; addiction module antidote protein 574229..574624 Escherichia coli HS 5592602 YP_001457329.1 CDS EcHS_A0561 NC_009800.1 574665 574895 R identified by glimmer; hypothetical protein complement(574665..574895) Escherichia coli HS 5591206 YP_001457330.1 CDS EcHS_A0562 NC_009800.1 574766 575032 R identified by glimmer; hypothetical protein complement(574766..575032) Escherichia coli HS 5591207 YP_001457331.1 CDS copA NC_009800.1 575041 577545 R identified by match to protein family HMM PF00122; match to protein family HMM PF00403; match to protein family HMM PF00702; match to protein family HMM TIGR01494; match to protein family HMM TIGR01511; match to protein family HMM TIGR01525; copper exporting ATPase complement(575041..577545) Escherichia coli HS 5591208 YP_001457332.1 CDS glsA1 NC_009800.1 577807 578739 D catalyzes the formation of glutamate from glutamine; glutaminase 577807..578739 Escherichia coli HS 5593680 YP_001457333.1 CDS EcHS_A0565 NC_009800.1 578742 580034 D ybaT; identified by match to protein family HMM PF00324; match to protein family HMM PF01490; match to protein family HMM PF03845; amino acid permease 578742..580034 Escherichia coli HS 5593681 YP_001457334.1 CDS cueR NC_009800.1 580159 580566 D activator of copper-responsive regulon genes; DNA-binding transcriptional regulator CueR 580159..580566 Escherichia coli HS 5593682 YP_001457335.1 CDS EcHS_A0567 NC_009800.1 580567 581025 R ybbJ; identified by match to protein family HMM PF01957; nodulation efficiency family protein complement(580567..581025) Escherichia coli HS 5593858 YP_001457336.1 CDS EcHS_A0568 NC_009800.1 581022 581939 R identified by match to protein family HMM PF01145; SPFH domain-containing protein/band 7 family protein complement(581022..581939) Escherichia coli HS 5593859 YP_001457337.1 CDS EcHS_A0569 NC_009800.1 582085 582762 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein YbbL 582085..582762 Escherichia coli HS 5593860 YP_001457338.1 CDS EcHS_A0570 NC_009800.1 582749 583528 D identified by match to protein family HMM PF03649; match to protein family HMM TIGR00245; hypothetical protein 582749..583528 Escherichia coli HS 5594668 YP_001457339.1 CDS ybbN NC_009800.1 583591 584445 R identified by similarity to SP:P77395; match to protein family HMM PF00085; protein YbbN complement(583591..584445) Escherichia coli HS 5594669 YP_001457340.1 CDS EcHS_A0572 NC_009800.1 584506 585315 R identified by match to protein family HMM PF00106; match to protein family HMM PF08659; short chain dehydrogenase complement(584506..585315) Escherichia coli HS 5594670 YP_001457341.1 CDS tesA NC_009800.1 585305 585928 R identified by similarity to SP:P0ADA1; match to protein family HMM PF00657; multifunctional acyl-CoA thioesterase I and protease I and lysophospholipase L1 complement(585305..585928) Escherichia coli HS 5594104 YP_001457342.1 CDS EcHS_A0573 NC_009800.1 585899 586585 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein YbbA 585899..586585 Escherichia coli HS 5594105 YP_001457343.1 CDS EcHS_A0575 NC_009800.1 586582 588996 D identified by match to protein family HMM PF02687; ABC transporter permease 586582..588996 Escherichia coli HS 5594106 YP_001457344.1 CDS selU NC_009800.1 589709 590803 R catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA; tRNA 2-selenouridine synthase complement(589709..590803) Escherichia coli HS 5591474 YP_001457345.1 CDS EcHS_A0578 NC_009800.1 590872 591798 R activator of the allDC-ylbA operon involved in allantoin utilization; DNA-binding transcriptional activator AllS complement(590872..591798) Escherichia coli HS 5591475 YP_001457346.1 CDS allA NC_009800.1 592028 592510 D catalyzes the formation of glyoxylate from (S)-ureidoglycolate; ureidoglycolate hydrolase 592028..592510 Escherichia coli HS 5591476 YP_001457347.1 CDS allR NC_009800.1 592588 593403 D regulates operons involved in the utilization of allantoin; DNA-binding transcriptional repressor AllR 592588..593403 Escherichia coli HS 5591960 YP_001457348.1 CDS gcl NC_009800.1 593493 595274 D catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate; glyoxylate carboligase 593493..595274 Escherichia coli HS 5591961 YP_001457349.1 CDS hyi NC_009800.1 595287 596063 D identified by similarity to SP:P30147; match to protein family HMM PF01261; match to protein family HMM TIGR03234; hydroxypyruvate isomerase 595287..596063 Escherichia coli HS 5591962 YP_001457350.1 CDS EcHS_A0583 NC_009800.1 596163 597041 D identified by match to protein family HMM PF03446; match to protein family HMM TIGR01505; 2-hydroxy-3-oxopropionate reductase 596163..597041 Escherichia coli HS 5592278 YP_001457351.1 CDS EcHS_A0584 NC_009800.1 597210 598664 D identified by match to protein family HMM PF02133; match to protein family HMM TIGR00800; allantoin permease 597210..598664 Escherichia coli HS 5592279 YP_001457352.1 CDS allB NC_009800.1 598724 600085 D Plays a crucial role on both purine and pyrimidine metabolism; allantoinase 598724..600085 Escherichia coli HS 5592280 YP_001457353.1 CDS EcHS_A0586 NC_009800.1 600142 601443 D identified by match to protein family HMM PF00860; purine permease YbbY 600142..601443 Escherichia coli HS 5592086 YP_001457354.1 CDS EcHS_A0587 NC_009800.1 601465 602610 D identified by match to protein family HMM PF02595; match to protein family HMM TIGR00045; glycerate kinase II 601465..602610 Escherichia coli HS 5592087 YP_001457355.1 CDS EcHS_A0588 NC_009800.1 602669 602809 D identified by glimmer; hypothetical protein 602669..602809 Escherichia coli HS 5592088 YP_001457356.1 CDS EcHS_A0589 NC_009800.1 602838 603623 R ylbA; identified by similarity to GB:CAD05010.1; match to protein family HMM PF05899; match to protein family HMM PF07883; match to protein family HMM TIGR03214; hypothetical protein complement(602838..603623) Escherichia coli HS 5592411 YP_001457357.1 CDS allC NC_009800.1 603634 604869 R allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide; allantoate amidohydrolase complement(603634..604869) Escherichia coli HS 5592412 YP_001457358.1 CDS allD NC_009800.1 604891 605940 R identified by similarity to SP:P77555; match to protein family HMM PF02615; match to protein family HMM TIGR03175; ureidoglycolate dehydrogenase complement(604891..605940) Escherichia coli HS 5592413 YP_001457359.1 CDS EcHS_A0592 NC_009800.1 606257 607924 D multicopy suppressor of dominant negative ftsH mutations; membrane protein FdrA 606257..607924 Escherichia coli HS 5593164 YP_001457360.1 CDS EcHS_A0593 NC_009800.1 607934 609193 D ylbE; identified by match to protein family HMM PF06545; hypothetical protein 607934..609193 Escherichia coli HS 5593165 YP_001457361.1 CDS EcHS_A0594 NC_009800.1 609204 610019 D ylbF; hypothetical protein 609204..610019 Escherichia coli HS 5593166 YP_001457362.1 CDS arcC NC_009800.1 610016 610909 D identified by match to protein family HMM PF00696; match to protein family HMM TIGR00746; carbamate kinase 610016..610909 Escherichia coli HS 5594758 YP_001457363.1 CDS EcHS_A0596 NC_009800.1 610909 611055 D identified by glimmer; hypothetical protein 610909..611055 Escherichia coli HS 5594759 YP_001457364.1 CDS purK NC_009800.1 611048 612115 R With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit complement(611048..612115) Escherichia coli HS 5594760 YP_001457365.1 CDS purE NC_009800.1 612112 612621 R identified by similarity to SP:P0AG18; match to protein family HMM PF00731; match to protein family HMM TIGR01162; phosphoribosylaminoimidazole carboxylase catalytic subunit complement(612112..612621) Escherichia coli HS 5594184 YP_001457366.1 CDS lpxH NC_009800.1 612739 613461 R catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine; UDP-2,3-diacylglucosamine hydrolase complement(612739..613461) Escherichia coli HS 5594185 YP_001457367.1 CDS ppiB NC_009800.1 613464 613958 R identified by similarity to SP:P23869; match to protein family HMM PF00160; peptidyl-prolyl cis-trans isomerase B (rotamase B) complement(613464..613958) Escherichia coli HS 5594186 YP_001457368.1 CDS cysS NC_009800.1 614132 615517 D catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 614132..615517 Escherichia coli HS 5594790 YP_001457369.1 CDS EcHS_A0602 NC_009800.1 615553 616074 R ybcI; identified by match to protein family HMM PF04307; hypothetical protein complement(615553..616074) Escherichia coli HS 5594791 YP_001457370.1 CDS folD NC_009800.1 616396 617262 R identified by similarity to SP:P24186; match to protein family HMM PF00763; match to protein family HMM PF02882; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase complement(616396..617262) Escherichia coli HS 5594792 YP_001457371.1 CDS EcHS_A0604 NC_009800.1 617743 618285 D identified by similarity to SP:P04128; match to protein family HMM PF00419; type-1 fimbrial protein 617743..618285 Escherichia coli HS 5594810 YP_001457372.1 CDS EcHS_A0605 NC_009800.1 618381 618515 D identified by glimmer; hypothetical protein 618381..618515 Escherichia coli HS 5594811 YP_001457373.1 CDS EcHS_A0606 NC_009800.1 618505 619197 D identified by match to protein family HMM PF00345; match to protein family HMM PF02753; chaperone protein FimC-like protein 618505..619197 Escherichia coli HS 5594812 YP_001457374.1 CDS fimD2 NC_009800.1 619228 621837 D identified by similarity to SP:P30130; match to protein family HMM PF00577; outer membrane usher protein fimD 619228..621837 Escherichia coli HS 5591969 YP_001457375.1 CDS EcHS_A0608 NC_009800.1 621850 622857 D identified by similarity to GB:AAD17914.1; mannose binding protein FimH-like protein 621850..622857 Escherichia coli HS 5591970 YP_001457376.1 CDS EcHS_A0609 NC_009800.1 622868 623383 D identified by similarity to SP:P37921; match to protein family HMM PF00419; fimbrial protein 622868..623383 Escherichia coli HS 5591971 YP_001457377.1 CDS fimZ NC_009800.1 623386 624018 R activates the production of the major fimbrae protein FimA; transcriptional regulator FimZ complement(623386..624018) Escherichia coli HS 5591426 YP_001457378.1 CDS EcHS_A0615 NC_009800.1 626289 626750 R NULL; identified by similarity to GB:CAE12649.1; match to protein family HMM PF08786; hypothetical protein complement(626289..626750) Escherichia coli HS 5595381 YP_001457379.1 CDS EcHS_A0616 NC_009800.1 626778 628679 R identified by match to protein family HMM PF04524; match to protein family HMM TIGR01646; match to protein family HMM TIGR03361; type VI secretion system Vgr family protein complement(626778..628679) Escherichia coli HS 5594987 YP_001457380.1 CDS cusS NC_009800.1 629416 630864 R identified by similarity to SP:P77485; match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM TIGR01386; sensor kinase CusS complement(629416..630864) Escherichia coli HS 5594988 YP_001457381.1 CDS cusR NC_009800.1 630854 631537 R response regulator in two-component regulatory system with CusS; regulates the copper efflux system; DNA-binding transcriptional activator CusR complement(630854..631537) Escherichia coli HS 5594989 YP_001457382.1 CDS cusC NC_009800.1 631694 633067 D with CusA, CusB and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system outer membrane protein CusC 631694..633067 Escherichia coli HS 5594990 YP_001457383.1 CDS cusF NC_009800.1 633225 633557 D ylcC; periplasmic copper-binding protein 633225..633557 Escherichia coli HS 5591236 YP_001457384.1 CDS cusB NC_009800.1 633573 634796 D with CusA, CusC and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system membrane fusion protein CusB 633573..634796 Escherichia coli HS 5591237 YP_001457385.1 CDS cusA NC_009800.1 634808 637951 D identified by match to protein family HMM PF00873; match to protein family HMM TIGR00914; cation efflux system protein cusA 634808..637951 Escherichia coli HS 5591238 YP_001457386.1 CDS pheP NC_009800.1 638053 639429 D identified by similarity to SP:P24207; match to protein family HMM PF00324; phenylalanine transporter 638053..639429 Escherichia coli HS 5594645 YP_001457387.1 CDS EcHS_A0624 NC_009800.1 639497 640744 R identified by match to protein family HMM PF00924; small conductance mechanosensitive ion channel (MscS) family protein complement(639497..640744) Escherichia coli HS 5594646 YP_001457388.1 CDS nfnB NC_009800.1 640852 641505 R catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive; dihydropteridine reductase complement(640852..641505) Escherichia coli HS 5594647 YP_001457389.1 CDS EcHS_A0626 NC_009800.1 641599 641967 R ybdF; identified by similarity to GB:BAA35219.1; match to protein family HMM PF04237; hypothetical protein complement(641599..641967) Escherichia coli HS 5591152 YP_001457390.1 CDS EcHS_A0627 NC_009800.1 642032 642280 R ybdJ; identified by match to protein family HMM PF06643; lipoprotein complement(642032..642280) Escherichia coli HS 5591153 YP_001457391.1 CDS EcHS_A0628 NC_009800.1 642346 643464 R ATP-dependent; carboxylate-amine ligase with weak glutamate--cysteine ligase activity; carboxylate-amine ligase complement(642346..643464) Escherichia coli HS 5591154 YP_001457392.1 CDS EcHS_A0629 NC_009800.1 643818 644069 D identified by match to protein family HMM PF01848; Hok/Gef family protein 643818..644069 Escherichia coli HS 5595456 YP_001457393.1 CDS EcHS_A0630 NC_009800.1 644146 645258 D identified by match to protein family HMM PF01609; IS186, transposase 644146..645258 Escherichia coli HS 5595457 YP_001457394.1 CDS entD NC_009800.1 645540 646169 R identified by similarity to SP:P19925; match to protein family HMM PF01648; phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex complement(645540..646169) Escherichia coli HS 5595458 YP_001457395.1 CDS fepA NC_009800.1 646335 648575 R Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space; outer membrane receptor FepA complement(646335..648575) Escherichia coli HS 5593705 YP_001457396.1 CDS EcHS_A0632 NC_009800.1 648568 648699 D identified by glimmer; hypothetical protein 648568..648699 Escherichia coli HS 5593706 YP_001457397.1 CDS fes NC_009800.1 648896 650020 D identified by similarity to SP:P13039; match to protein family HMM PF00756; enterobactin/ferric enterobactin esterase 648896..650020 Escherichia coli HS 5593707 YP_001457398.1 CDS EcHS_A0635 NC_009800.1 650023 650241 D identified by match to protein family HMM PF03621; mbtH-like protein 650023..650241 Escherichia coli HS 5595382 YP_001457399.1 CDS entF NC_009800.1 650238 654119 D with EntB, EntD, and EntE forms the multienzyme complex enterobactin synthase; EntF is the serine activating enzyme which catalyzes the formation of the amide and ester bonds of the cyclic enterobactin; enterobactin synthase subunit F 650238..654119 Escherichia coli HS 5595383 YP_001457400.1 CDS EcHS_A0637 NC_009800.1 654108 654227 R identified by glimmer; hypothetical protein complement(654108..654227) Escherichia coli HS 5595384 YP_001457401.1 CDS fepE NC_009800.1 654335 655468 D part of the ferric enterobactin transport system; necessary for enetrobactin uptake; ferric enterobactin transport protein FepE 654335..655468 Escherichia coli HS 5595504 YP_001457402.1 CDS fepC NC_009800.1 655465 656280 R with FepBDE is involved in the transport of ferric enterobactin; iron-enterobactin transporter ATP-binding protein complement(655465..656280) Escherichia coli HS 5595505 YP_001457403.1 CDS fepG NC_009800.1 656277 657269 R with FepBCD is involved in the transport of ferric enterobactin; iron-enterobactin transporter permease complement(656277..657269) Escherichia coli HS 5595506 YP_001457404.1 CDS fepD NC_009800.1 657266 658270 R with FepBCG is involved in the transport of ferric enterobactin; iron-enterobactin transporter membrane protein complement(657266..658270) Escherichia coli HS 5591535 YP_001457405.1 CDS EcHS_A0642 NC_009800.1 658381 659631 D protein p43; inner membrane protein that exports enterobactin to the periplasmic space; member of the major facilitator superfamily (MFS) of transporters; enterobactin exporter EntS 658381..659631 Escherichia coli HS 5591536 YP_001457406.1 CDS fepB NC_009800.1 659635 660591 R with FepCDG is involved in the transport of ferric enterobactin; iron-enterobactin transporter periplasmic binding protein complement(659635..660591) Escherichia coli HS 5591537 YP_001457407.1 CDS entC NC_009800.1 660966 662141 D identified by similarity to SP:P0AEJ2; match to protein family HMM PF00425; match to protein family HMM TIGR00543; isochorismate synthase 660966..662141 Escherichia coli HS 5591299 YP_001457408.1 CDS entE NC_009800.1 662151 663761 D bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate; enterobactin synthase subunit E 662151..663761 Escherichia coli HS 5591300 YP_001457409.1 CDS entB NC_009800.1 663775 664632 D identified by similarity to SP:P0ADI4; match to protein family HMM PF00550; match to protein family HMM PF00857; isochorismatase 663775..664632 Escherichia coli HS 5591301 YP_001457410.1 CDS entA NC_009800.1 664632 665378 D catalyzes the formation of 2,3-dihydroxybenzoate from 2,3-dihydro-2,3-dihydroxybenzoate; involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin; 2,3-dihydroxybenzoate-2,3-dehydrogenase 664632..665378 Escherichia coli HS 5595314 YP_001457411.1 CDS EcHS_A0648 NC_009800.1 665381 665794 D ybdB; identified by match to protein family HMM PF03061; match to protein family HMM TIGR00369; hypothetical protein 665381..665794 Escherichia coli HS 5595315 YP_001457412.1 CDS cstA NC_009800.1 665975 668080 D identified by similarity to SP:P15078; match to protein family HMM PF02554; carbon starvation protein A 665975..668080 Escherichia coli HS 5595316 YP_001457413.1 CDS EcHS_A0650 NC_009800.1 668263 668460 D identified by similarity to SP:P0AAT1; match to protein family HMM PF04328; hypothetical protein 668263..668460 Escherichia coli HS 5594781 YP_001457414.1 CDS EcHS_A0651 NC_009800.1 668470 669558 R member of the iron-containing alcohol dehydrogenase; unknown function; hypothetical protein complement(668470..669558) Escherichia coli HS 5594782 YP_001457415.1 CDS EcHS_A0652 NC_009800.1 669667 670827 D catalyzes the transfer of an amino moiety; aminotransferase 669667..670827 Escherichia coli HS 5594783 YP_001457416.1 CDS EcHS_A0653 NC_009800.1 670828 671445 R ybdM; identified by match to protein family HMM PF02195; IbrB protein complement(670828..671445) Escherichia coli HS 5591872 YP_001457417.1 CDS EcHS_A0654 NC_009800.1 671430 672650 R ybdN; identified by match to protein family HMM PF01507; IbrA protein complement(671430..672650) Escherichia coli HS 5591873 YP_001457418.1 CDS EcHS_A0655 NC_009800.1 672797 673699 R identified by match to protein family HMM PF00126; LysR family transcriptional regulator complement(672797..673699) Escherichia coli HS 5591874 YP_001457419.1 CDS dsbG NC_009800.1 673908 674654 R Involved in disulfide bond formation; disulfide isomerase/thiol-disulfide oxidase complement(673908..674654) Escherichia coli HS 5594642 YP_001457420.1 CDS ahpC NC_009800.1 675026 675589 D with AhpF catalyzes the conversion of alkyl hydroperoxides to their corresponding alcohols; AhpC reduced the hydroperoxide substrate; alkyl hydroperoxide reductase 675026..675589 Escherichia coli HS 5594643 YP_001457421.1 CDS ahpF NC_009800.1 675804 677399 D identified by match to protein family HMM PF00070; match to protein family HMM PF07992; match to protein family HMM TIGR03140; alkyl hydroperoxide reductase 675804..677399 Escherichia coli HS 5594644 YP_001457422.1 CDS uspG NC_009800.1 677520 677948 R ybdQ; identified by similarity to SP:P39177; match to protein family HMM PF00582; universal stress protein G complement(677520..677948) Escherichia coli HS 5594587 YP_001457423.1 CDS EcHS_A0660 NC_009800.1 678169 679407 D identified by similarity to SP:P77316; match to protein family HMM PF00107; match to protein family HMM PF08240; zinc-binding dehydrogenase oxidoreductase 678169..679407 Escherichia coli HS 5594588 YP_001457424.1 CDS rnk NC_009800.1 679638 680048 R Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation; nucleoside diphosphate kinase regulator complement(679638..680048) Escherichia coli HS 5594589 YP_001457425.1 CDS rna NC_009800.1 680277 681083 R identified by similarity to SP:P21338; match to protein family HMM PF00445; ribonuclease I complement(680277..681083) Escherichia coli HS 5595371 YP_001457426.1 CDS EcHS_A0663 NC_009800.1 681197 682660 R identified by match to protein family HMM PF00939; match to protein family HMM TIGR00785; sodium:sulfate symporter family protein complement(681197..682660) Escherichia coli HS 5595372 YP_001457427.1 CDS citG NC_009800.1 682711 683589 R catalyzes the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA from ATP and 3-dephospho-CoA; triphosphoribosyl-dephospho-CoA synthase complement(682711..683589) Escherichia coli HS 5595373 YP_001457428.1 CDS citX NC_009800.1 683564 684115 R 2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase; holo-citrate lyase synthase; CitG forms the prosthetic group precursor 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA which is then transferred to apo-ACP by CitX to produce holo-ACP and pyrophosphate; 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo- citrate lyase complement(683564..684115) Escherichia coli HS 5593590 YP_001457429.1 CDS citF NC_009800.1 684119 685651 R identified by match to protein family HMM PF04223; match to protein family HMM TIGR01584; citrate lyase alpha chain complement(684119..685651) Escherichia coli HS 5593591 YP_001457430.1 CDS citE NC_009800.1 685662 686570 R identified by match to protein family HMM PF03328; match to protein family HMM TIGR01588; citrate (pro-3S)-lyase, beta subunit complement(685662..686570) Escherichia coli HS 5593592 YP_001457431.1 CDS citD NC_009800.1 686567 686863 R acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate; citrate lyase subunit gamma complement(686567..686863) Escherichia coli HS 5594831 YP_001457432.1 CDS citC NC_009800.1 686878 687936 R identified by similarity to SP:P77390; match to protein family HMM PF00583; match to protein family HMM PF08218; match to protein family HMM TIGR00124; match to protein family HMM TIGR00125; [citrate (pro-3S)-lyase] ligase complement(686878..687936) Escherichia coli HS 5594832 YP_001457433.1 CDS dpiB NC_009800.1 688316 689974 D identified by similarity to SP:P77510; match to protein family HMM PF02518; sensor histidine kinase DpiB 688316..689974 Escherichia coli HS 5594833 YP_001457434.1 CDS dpiA NC_009800.1 689943 690623 D regulates the expression of citAB in citrate fermentation; two-component response regulator DpiA 689943..690623 Escherichia coli HS 5594748 YP_001457435.1 CDS EcHS_A0673 NC_009800.1 692188 692334 R identified by glimmer; hypothetical protein complement(692188..692334) Escherichia coli HS 5594750 YP_001457436.1 CDS pagP NC_009800.1 692638 693198 D catalyzes the transfer of palmitate to lipid A; palmitoyl transferase 692638..693198 Escherichia coli HS 5591155 YP_001457437.1 CDS cspE NC_009800.1 693373 693582 D member of the CspA family; constitutively expressed RNA/ssDNA-binding protein; functions in helping cells adapt to low temperature; aids nucleic acid melting; participates in gene regulation; can act as a transcription antiterminator; cold shock protein CspE 693373..693582 Escherichia coli HS 5591156 YP_001457438.1 CDS crcB NC_009800.1 693637 694020 R identified by similarity to SP:P37002; match to protein family HMM PF02537; match to protein family HMM TIGR00494; CrcB protein complement(693637..694020) Escherichia coli HS 5591157 YP_001457439.1 CDS EcHS_A0677 NC_009800.1 694113 694901 D ybeH; identified by match to protein family HMM PF00795; carbon-nitrogen family hydrolase 694113..694901 Escherichia coli HS 5593238 YP_001457440.1 CDS tatE NC_009800.1 695030 695233 D TatE; similar to TatA and found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase E 695030..695233 Escherichia coli HS 5593239 YP_001457441.1 CDS lipA NC_009800.1 695334 696299 R catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase complement(695334..696299) Escherichia coli HS 5593240 YP_001457442.1 CDS EcHS_A0680 NC_009800.1 696398 696511 R identified by glimmer; hypothetical protein complement(696398..696511) Escherichia coli HS 5594602 YP_001457443.1 CDS EcHS_A0681 NC_009800.1 696508 697461 R identified by match to protein family HMM PF00126; match to protein family HMM PF03466; DNA-binding transcriptional regulator complement(696508..697461) Escherichia coli HS 5594603 YP_001457444.1 CDS lipB NC_009800.1 697720 698361 R lipoyl-[acyl-carrier protein]-protein-N-lipoyltransferse; lipoate-protein ligase B; transfers lipoate to apolipoproteins; involved in lipoate metabolism; lipoyltransferase complement(697720..698361) Escherichia coli HS 5594604 YP_001457445.1 CDS EcHS_A0683 NC_009800.1 698462 698725 R ybeD; identified by similarity to SP:P0A8J4; match to protein family HMM PF04359; hypothetical protein complement(698462..698725) Escherichia coli HS 5594966 YP_001457446.1 CDS rlpA NC_009800.1 700187 701275 R identified by similarity to SP:P10100; match to protein family HMM PF03330; match to protein family HMM PF05036; match to protein family HMM TIGR00413; rare lipoprotein A complement(700187..701275) Escherichia coli HS 5594968 YP_001457447.1 CDS mrdB NC_009800.1 701286 702398 R identified by similarity to SP:P0ABG7; match to protein family HMM PF01098; match to protein family HMM TIGR02210; cell wall shape-determining protein complement(701286..702398) Escherichia coli HS 5591110 YP_001457448.1 CDS mrdA NC_009800.1 702401 704302 R identified by match to protein family HMM PF00905; match to protein family HMM PF03717; match to protein family HMM TIGR03423; penicillin-binding protein 2 complement(702401..704302) Escherichia coli HS 5591111 YP_001457449.1 CDS EcHS_A0688 NC_009800.1 704333 704800 R SPOUT methyltransferase; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase complement(704333..704800) Escherichia coli HS 5591112 YP_001457450.1 CDS EcHS_A0689 NC_009800.1 704804 705121 R identified by match to protein family HMM PF02410; match to protein family HMM TIGR00090; hypothetical protein complement(704804..705121) Escherichia coli HS 5593071 YP_001457451.1 CDS cobC NC_009800.1 705381 705992 R identified by similarity to SP:P52086; match to protein family HMM PF00300; match to protein family HMM TIGR03162; alpha-ribazole-5'-phosphate phosphatase complement(705381..705992) Escherichia coli HS 5593072 YP_001457452.1 CDS nadD NC_009800.1 706016 706657 R transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase complement(706016..706657) Escherichia coli HS 5593073 YP_001457453.1 CDS holA NC_009800.1 706659 707690 R required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta complement(706659..707690) Escherichia coli HS 5593880 YP_001457454.1 CDS EcHS_A0693 NC_009800.1 707690 708271 R rare lipoprotein B; involved in the assembly of LPS in the outer membrane; LPS-assembly lipoprotein RlpB complement(707690..708271) Escherichia coli HS 5593881 YP_001457455.1 CDS leuS NC_009800.1 708286 710868 R leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase complement(708286..710868) Escherichia coli HS 5593882 YP_001457456.1 CDS EcHS_A0695 NC_009800.1 711103 711585 D identified by similarity to SP:P0AAT9; match to protein family HMM PF07295; hypothetical protein 711103..711585 Escherichia coli HS 5595101 YP_001457457.1 CDS rihA NC_009800.1 711625 712560 R Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively; pyrimidine-specific; ribonucleoside hydrolase 1 complement(711625..712560) Escherichia coli HS 5595102 YP_001457458.1 CDS gltL NC_009800.1 712678 713403 R identified by match to protein family HMM PF00005; glutamate/aspartate ABC transporter ATP-binding protein complement(712678..713403) Escherichia coli HS 5595103 YP_001457459.1 CDS gltK NC_009800.1 713403 714077 R identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; glutamate/aspartate ABC transporter permease GltK complement(713403..714077) Escherichia coli HS 5595368 YP_001457460.1 CDS gltJ NC_009800.1 714077 714817 R identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; glutamate/aspartate ABC transporter permease GltJ complement(714077..714817) Escherichia coli HS 5595369 YP_001457461.1 CDS gltI NC_009800.1 714987 715895 R identified by match to protein family HMM PF00497; glutamate and aspartate transporter subunit complement(714987..715895) Escherichia coli HS 5591010 YP_001457462.1 CDS EcHS_A0701 NC_009800.1 716030 716152 D identified by glimmer; hypothetical protein 716030..716152 Escherichia coli HS 5591011 YP_001457463.1 CDS lnt NC_009800.1 718353 719891 R Transfers the fatty acyl group on membrane lipoproteins; apolipoprotein N-acyltransferase complement(718353..719891) Escherichia coli HS 5592027 YP_001457464.1 CDS corC NC_009800.1 719916 720794 R identified by match to protein family HMM PF00571; match to protein family HMM PF03471; magnesium and cobalt efflux protein CorC complement(719916..720794) Escherichia coli HS 5592028 YP_001457465.1 CDS EcHS_A0706 NC_009800.1 720884 721351 R identified by match to protein family HMM PF02130; match to protein family HMM TIGR00043; metalloprotease complement(720884..721351) Escherichia coli HS 5591258 YP_001457466.1 CDS EcHS_A0707 NC_009800.1 721348 722388 R identified by match to protein family HMM PF02562; PhoH family protein complement(721348..722388) Escherichia coli HS 5591259 YP_001457467.1 CDS miaB NC_009800.1 722541 723965 R identified by match to protein family HMM PF00919; match to protein family HMM PF01938; match to protein family HMM PF04055; match to protein family HMM TIGR00089; match to protein family HMM TIGR01574; tRNA-i(6)A37 thiotransferase enzyme MiaB complement(722541..723965) Escherichia coli HS 5591260 YP_001457468.1 CDS ubiF NC_009800.1 724111 725286 D catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol; functions in the biosynthesis of ubiquinone or coenzyme Q; 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase 724111..725286 Escherichia coli HS 5591471 YP_001457469.1 CDS asnB NC_009800.1 726523 728187 R functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP; asparagine synthetase B complement(726523..728187) Escherichia coli HS 5594995 YP_001457470.1 CDS EcHS_A0718 NC_009800.1 728613 729593 R identified by match to protein family HMM PF01548; match to protein family HMM PF02371; IS621, transposase complement(728613..729593) Escherichia coli HS 5594543 YP_001457471.1 CDS nagD NC_009800.1 729863 730615 R identified by similarity to SP:P15302; match to protein family HMM PF00702; match to protein family HMM TIGR01460; UMP phosphatase complement(729863..730615) Escherichia coli HS 5594544 YP_001457472.1 CDS nagC NC_009800.1 730663 731883 R identified by match to protein family HMM PF00480; N-acetylglucosamine repressor complement(730663..731883) Escherichia coli HS 5591761 YP_001457473.1 CDS nagA NC_009800.1 731892 733040 R catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate; N-acetylglucosamine-6-phosphate deacetylase complement(731892..733040) Escherichia coli HS 5591762 YP_001457474.1 CDS nagB NC_009800.1 733100 733900 R catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate; glucosamine-6-phosphate deaminase complement(733100..733900) Escherichia coli HS 5591763 YP_001457475.1 CDS nagE NC_009800.1 734233 736179 D phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; N-acetyl glucosamine specific PTS system components IIABC 734233..736179 Escherichia coli HS 5592647 YP_001457476.1 CDS EcHS_A0724 NC_009800.1 736186 736329 R identified by glimmer; hypothetical protein complement(736186..736329) Escherichia coli HS 5592648 YP_001457477.1 CDS glnS NC_009800.1 736447 738111 D catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glutaminyl-tRNA synthetase 736447..738111 Escherichia coli HS 5592649 YP_001457478.1 CDS EcHS_A0727 NC_009800.1 738387 738497 R identified by glimmer; hypothetical protein complement(738387..738497) Escherichia coli HS 5593045 YP_001457479.1 CDS EcHS_A0728 NC_009800.1 738688 740094 D ybfM; identified by match to protein family HMM PF03573; OprD family outer membrane porin 738688..740094 Escherichia coli HS 5593046 YP_001457480.1 CDS EcHS_A0729 NC_009800.1 740144 740470 D ybfN; lipoprotein 740144..740470 Escherichia coli HS 5593047 YP_001457481.1 CDS fur NC_009800.1 740554 741000 R negatively regulates a number of operons that encode enzymes involved in iron transport; activated by manganese; forms a homodimer; ferric uptake regulator complement(740554..741000) Escherichia coli HS 5592301 YP_001457482.1 CDS fldA NC_009800.1 741289 741936 R An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin FldA complement(741289..741936) Escherichia coli HS 5592302 YP_001457483.1 CDS EcHS_A0732 NC_009800.1 741959 742252 R ybfE; identified by match to protein family HMM PF01402; LexA regulated protein complement(741959..742252) Escherichia coli HS 5592303 YP_001457484.1 CDS ybfF NC_009800.1 742392 743156 R identified by similarity to SP:P75736; match to protein family HMM PF00561; match to protein family HMM PF07819; hypothetical protein complement(742392..743156) Escherichia coli HS 5595390 YP_001457485.1 CDS seqA NC_009800.1 743341 743886 D negative modulator of the initiation of chromosome replication; replication initiation regulator SeqA 743341..743886 Escherichia coli HS 5595391 YP_001457486.1 CDS pgm NC_009800.1 743912 745552 D catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase 743912..745552 Escherichia coli HS 5595392 YP_001457487.1 CDS EcHS_A0736 NC_009800.1 745558 745731 R identified by glimmer; hypothetical protein complement(745558..745731) Escherichia coli HS 5594060 YP_001457488.1 CDS EcHS_A0737 NC_009800.1 745767 746282 D lipoprotein 745767..746282 Escherichia coli HS 5594061 YP_001457489.1 CDS EcHS_A0738 NC_009800.1 746311 746586 D identified by match to protein family HMM PF03811; IS1, transposase orfA 746311..746586 Escherichia coli HS 5594062 YP_001457490.1 CDS EcHS_A0739 NC_009800.1 746505 747008 D identified by match to protein family HMM PF03400; IS1, transposase orfB 746505..747008 Escherichia coli HS 5592170 YP_001457491.1 CDS EcHS_A0740 NC_009800.1 747010 747114 D NULL; identified by similarity to GB:AAN42241.1; hypothetical protein 747010..747114 Escherichia coli HS 5592171 YP_001457492.1 CDS kdpE NC_009800.1 747136 747813 R response regulator in two-component regulatory system with KdpD; regulates the kdp operon involved in potassium transport; DNA-binding transcriptional activator KdpE complement(747136..747813) Escherichia coli HS 5592172 YP_001457493.1 CDS kdpD NC_009800.1 747810 750494 R sensory histidine kinase in two-component regulatory system with KdpE; signal sensing protein; sensor protein KdpD complement(747810..750494) Escherichia coli HS 5592972 YP_001457494.1 CDS kdpC NC_009800.1 750487 751059 R One of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex; potassium-transporting ATPase subunit C complement(750487..751059) Escherichia coli HS 5592973 YP_001457495.1 CDS kdpB NC_009800.1 751068 753116 R One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit B complement(751068..753116) Escherichia coli HS 5592974 YP_001457496.1 CDS kdpA NC_009800.1 753139 754812 R catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit A complement(753139..754812) Escherichia coli HS 5591264 YP_001457497.1 CDS kdpF NC_009800.1 754812 755015 R identified by match to protein family HMM TIGR02115; K+-transporting ATPase, F subunit complement(754812..755015) Escherichia coli HS 5591265 YP_001457498.1 CDS EcHS_A0747 NC_009800.1 755214 755420 D ybfA; identified by similarity to GB:AAN79258.1; hypothetical protein 755214..755420 Escherichia coli HS 5591266 YP_001457499.1 CDS rhsC NC_009800.1 755663 759856 D identified by similarity to SP:P16918; match to protein family HMM PF03527; match to protein family HMM PF05593; match to protein family HMM TIGR01643; RhsC protein 755663..759856 Escherichia coli HS 5592504 YP_001457500.1 CDS EcHS_A0749 NC_009800.1 760300 761733 D identified by match to protein family HMM PF03527; match to protein family HMM PF05593; RHS repeat-containing protein 760300..761733 Escherichia coli HS 5592505 YP_001457501.1 CDS EcHS_A0750 NC_009800.1 761730 762299 D ybfC; identified by glimmer; hypothetical protein 761730..762299 Escherichia coli HS 5592506 YP_001457502.1 CDS EcHS_A0751 NC_009800.1 762525 762779 D identified by similarity to GB:BAA35363.1; ISEc2, transposase 762525..762779 Escherichia coli HS 5594289 YP_001457503.1 CDS EcHS_A0753 NC_009800.1 764172 764933 D identified by match to protein family HMM PF01609; ISEc4, transposase 764172..764933 Escherichia coli HS 5594291 YP_001457504.1 CDS EcHS_A0754 NC_009800.1 765081 765590 D ybgA; identified by similarity to GB:AAN79259.1; match to protein family HMM PF08349; hypothetical protein 765081..765590 Escherichia coli HS 5592817 YP_001457505.1 CDS phrB NC_009800.1 765587 767005 D UV-induced DNA repair; converts cyclobutane-type pyrimidine dimers created during exposure to UV ratiation to monomers; light dependent; deoxyribodipyrimidine photolyase 765587..767005 Escherichia coli HS 5592818 YP_001457506.1 CDS EcHS_A0756 NC_009800.1 767039 767158 D identified by glimmer; hypothetical protein 767039..767158 Escherichia coli HS 5592819 YP_001457507.1 CDS EcHS_A0757 NC_009800.1 767155 768636 R identified by match to protein family HMM PF00854; match to protein family HMM PF07690; match to protein family HMM TIGR00924; amino acid/peptide transporter complement(767155..768636) Escherichia coli HS 5592672 YP_001457508.1 CDS EcHS_A0758 NC_009800.1 768907 769650 D ybgI; identified by match to protein family HMM PF01784; match to protein family HMM TIGR00486; hydrolase-oxidase 768907..769650 Escherichia coli HS 5592673 YP_001457509.1 CDS EcHS_A0759 NC_009800.1 769673 770329 D identified by match to protein family HMM PF02682; match to protein family HMM TIGR00370; allophanate hydrolase, subunit 1 769673..770329 Escherichia coli HS 5592674 YP_001457510.1 CDS EcHS_A0760 NC_009800.1 770323 771255 D identified by match to protein family HMM PF02626; match to protein family HMM TIGR00724; allophanate hydrolase, subunit 2 770323..771255 Escherichia coli HS 5594724 YP_001457511.1 CDS EcHS_A0761 NC_009800.1 771245 771979 D identified by match to protein family HMM PF03746; LamB/YcsF family protein 771245..771979 Escherichia coli HS 5594725 YP_001457512.1 CDS nei NC_009800.1 772015 772806 D 5-formyluracil/5-hydroxymethyluracil DNA glycosylase; involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; acts as DNA glycosylase that recognizes and removes damaged bases with a preference for oxidized pyrimidines; has apurinic/apyrimidinic lyase activity; endonuclease VIII 772015..772806 Escherichia coli HS 5594726 YP_001457513.1 CDS abrB NC_009800.1 772803 773849 R identified by match to protein family HMM PF05145; match to protein family HMM TIGR03082; protein AbrB complement(772803..773849) Escherichia coli HS 5594674 YP_001457514.1 CDS EcHS_A0764 NC_009800.1 774001 775062 R ybgO; hypothetical protein complement(774001..775062) Escherichia coli HS 5594675 YP_001457515.1 CDS EcHS_A0765 NC_009800.1 775059 775790 R identified by match to protein family HMM PF00345; match to protein family HMM PF02753; periplasmic pilus chaperone family protein complement(775059..775790) Escherichia coli HS 5594676 YP_001457516.1 CDS EcHS_A0766 NC_009800.1 775805 778306 R identified by match to protein family HMM PF00577; fimbrial usher family protein complement(775805..778306) Escherichia coli HS 5594701 YP_001457517.1 CDS EcHS_A0767 NC_009800.1 778315 778881 R identified by similarity to SP:P04128; match to protein family HMM PF00419; type 1 fimbrial protein complement(778315..778881) Escherichia coli HS 5594702 YP_001457518.1 CDS gltA NC_009800.1 779270 780553 R type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase complement(779270..780553) Escherichia coli HS 5594703 YP_001457519.1 CDS sdhC NC_009800.1 781247 781651 D identified by match to protein family HMM PF01127; match to protein family HMM TIGR02970; succinate dehydrogenase cytochrome b556 large membrane subunit 781247..781651 Escherichia coli HS 5594369 YP_001457520.1 CDS sdhD NC_009800.1 781645 781992 D identified by match to protein family HMM TIGR02968; succinate dehydrogenase cytochrome b556 small membrane subunit 781645..781992 Escherichia coli HS 5594370 YP_001457521.1 CDS sdhA NC_009800.1 781992 783758 D part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 781992..783758 Escherichia coli HS 5594371 YP_001457522.1 CDS sdhB NC_009800.1 783774 784490 D part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 783774..784490 Escherichia coli HS 5594322 YP_001457523.1 CDS sucA NC_009800.1 784691 787492 D SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 784691..787492 Escherichia coli HS 5594323 YP_001457524.1 CDS sucB NC_009800.1 787507 788724 D component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA; dihydrolipoamide succinyltransferase 787507..788724 Escherichia coli HS 5594324 YP_001457525.1 CDS sucC NC_009800.1 789090 790256 D catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 789090..790256 Escherichia coli HS 5595143 YP_001457526.1 CDS sucD NC_009800.1 790256 791125 D Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 790256..791125 Escherichia coli HS 5595144 YP_001457527.1 CDS farR NC_009800.1 791229 791951 R regulates the succiny-lCoA synthetase operon; DNA-binding transcriptional repressor MngR complement(791229..791951) Escherichia coli HS 5595145 YP_001457528.1 CDS EcHS_A0778 NC_009800.1 792120 794036 D involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; 2-O-a-mannosyl-D-glycerate specific PTS transporten components IIABC 792120..794036 Escherichia coli HS 5595236 YP_001457529.1 CDS EcHS_A0780 NC_009800.1 794423 794926 R identified by match to protein family HMM PF03400; IS1, transposase orfB complement(794423..794926) Escherichia coli HS 5595238 YP_001457530.1 CDS EcHS_A0781 NC_009800.1 794845 795120 R identified by match to protein family HMM PF03811; IS1, transposase orfA complement(794845..795120) Escherichia coli HS 5593380 YP_001457531.1 CDS EcHS_A0783 NC_009800.1 797489 797716 D identified by similarity to GB:AAZ87440.1; hypothetical protein 797489..797716 Escherichia coli HS 5593382 YP_001457532.1 CDS EcHS_A0784 NC_009800.1 797793 797897 R identified by glimmer; hypothetical protein complement(797793..797897) Escherichia coli HS 5593429 YP_001457533.1 CDS cydA NC_009800.1 798311 799879 D identified by match to protein family HMM PF01654; cytochrome d ubiquinol oxidase, subunit I 798311..799879 Escherichia coli HS 5593430 YP_001457534.1 CDS cydB1 NC_009800.1 799895 801034 D identified by match to protein family HMM PF02322; match to protein family HMM TIGR00203; cytochrome d ubiquinol oxidase, subunit II 799895..801034 Escherichia coli HS 5593431 YP_001457535.1 CDS EcHS_A0787 NC_009800.1 801049 801162 D identified by match to protein family HMM PF08173; match to protein family HMM TIGR02106; cyd operon protein YbgT 801049..801162 Escherichia coli HS 5592713 YP_001457536.1 CDS EcHS_A0788 NC_009800.1 801162 801455 D ybgE; identified by match to protein family HMM TIGR02112; hypothetical protein 801162..801455 Escherichia coli HS 5592714 YP_001457537.1 CDS ybgC NC_009800.1 801605 802009 D catalyzes the hydrolysis of short chain aliphatic acyl-CoA thioesters; physiological role remains unknown; involved in phospholipid metabolism; part of the Tol/Pal system of proteins that are critical for maintaining the integrity of the cell envelope components; acyl-CoA thioester hydrolase 801605..802009 Escherichia coli HS 5592715 YP_001457538.1 CDS tolQ NC_009800.1 802006 802698 D membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolQ 802006..802698 Escherichia coli HS 5593288 YP_001457539.1 CDS tolR NC_009800.1 802702 803130 D membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolR 802702..803130 Escherichia coli HS 5593289 YP_001457540.1 CDS tolA NC_009800.1 803195 804460 D inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins; cell envelope integrity inner membrane protein TolA 803195..804460 Escherichia coli HS 5593290 YP_001457541.1 CDS pal NC_009800.1 805921 806442 D identified by match to protein family HMM PF00691; match to protein family HMM TIGR02802; peptidoglycan-associated outer membrane lipoprotein 805921..806442 Escherichia coli HS 5592048 YP_001457542.1 CDS ygbF NC_009800.1 806452 807243 D periplasmic protein that interacts with TolA; the tol-pal system is probably involved in maintaining cell envelope integrity; tol-pal system protein YbgF 806452..807243 Escherichia coli HS 5592049 YP_001457543.1 CDS nadA NC_009800.1 808686 809729 D 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 808686..809729 Escherichia coli HS 5593399 YP_001457544.1 CDS pnuC NC_009800.1 809782 810486 D identified by match to protein family HMM PF04973; match to protein family HMM TIGR01528; nicotinamide mononucleotide transporter PnuC 809782..810486 Escherichia coli HS 5592993 YP_001457545.1 CDS zitB NC_009800.1 810483 811424 R involved in zinc efflux across the cytoplasmic membrane; zinc transporter ZitB complement(810483..811424) Escherichia coli HS 5592994 YP_001457546.1 CDS EcHS_A0807 NC_009800.1 811538 811918 R hypothetical protein complement(811538..811918) Escherichia coli HS 5592995 YP_001457547.1 CDS aroG NC_009800.1 812234 813286 D catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 812234..813286 Escherichia coli HS 5592996 YP_001457548.1 CDS gpmA NC_009800.1 813444 814196 R identified by similarity to SP:P62707; match to protein family HMM PF00300; match to protein family HMM TIGR01258; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase complement(813444..814196) Escherichia coli HS 5593698 YP_001457549.1 CDS galM NC_009800.1 814399 815439 R catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose; aldose 1-epimerase complement(814399..815439) Escherichia coli HS 5593699 YP_001457550.1 CDS galK NC_009800.1 815433 816581 R catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase complement(815433..816581) Escherichia coli HS 5593700 YP_001457551.1 CDS galT NC_009800.1 816585 817631 R catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P; galactose-1-phosphate uridylyltransferase complement(816585..817631) Escherichia coli HS 5594479 YP_001457552.1 CDS galE NC_009800.1 817641 818657 R identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF05368; match to protein family HMM PF07993; match to protein family HMM TIGR01179; UDP-galactose-4-epimerase complement(817641..818657) Escherichia coli HS 5594480 YP_001457553.1 CDS modF NC_009800.1 818919 820391 R contains 2 ATP-binding cassettes; involved in the transport of molybdenum; molybdenum transport ATP-binding protein ModF complement(818919..820391) Escherichia coli HS 5594481 YP_001457554.1 CDS modE NC_009800.1 820459 821247 R represses the modABCD operon and activates the moaABCD and napFDAGHBC operons; DNA-binding transcriptional regulator ModE complement(820459..821247) Escherichia coli HS 5593006 YP_001457555.1 CDS EcHS_A0816 NC_009800.1 821376 821525 D ybhT; hypothetical protein 821376..821525 Escherichia coli HS 5593007 YP_001457556.1 CDS modA NC_009800.1 821692 822465 D with ModCB is involved in the high-affinity transport of molybdate; molybdate transporter periplasmic protein 821692..822465 Escherichia coli HS 5593008 YP_001457557.1 CDS modB NC_009800.1 822465 823154 D part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE; molybdate ABC transporter permease 822465..823154 Escherichia coli HS 5595497 YP_001457558.1 CDS modC NC_009800.1 823157 824215 D Part of the ABC transporter complex modABC involved in molybdenum import; molybdate transporter ATP-binding protein 823157..824215 Escherichia coli HS 5595498 YP_001457559.1 CDS ybhA NC_009800.1 824216 825034 R YbhA; catalyzes the dephosphorylation of pyridoxal phosphate, fructose 1,6-bisphosphate, erythrose 4-phosphate and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; phosphotransferase activity observed when using monophosphates as phosphate donor; member of the haloacid dehalogenase-like hydrolases superfamily; phosphotransferase complement(824216..825034) Escherichia coli HS 5595499 YP_001457560.1 CDS pgl NC_009800.1 825189 826184 D catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate; 6-phosphogluconolactonase 825189..826184 Escherichia coli HS 5592092 YP_001457561.1 CDS EcHS_A0822 NC_009800.1 826225 827178 R identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator complement(826225..827178) Escherichia coli HS 5592093 YP_001457562.1 CDS EcHS_A0823 NC_009800.1 827362 828414 D ybhH; identified by similarity to SP:P0AAV8; match to protein family HMM PF04303; hypothetical protein 827362..828414 Escherichia coli HS 5592094 YP_001457563.1 CDS EcHS_A0824 NC_009800.1 828490 829923 D identified by match to protein family HMM PF00939; match to protein family HMM PF03600; match to protein family HMM TIGR00785; anion transporter 828490..829923 Escherichia coli HS 5594742 YP_001457564.1 CDS EcHS_A0825 NC_009800.1 830082 832367 D identified by match to protein family HMM PF00330; match to protein family HMM PF00694; hypothetical protein 830082..832367 Escherichia coli HS 5594743 YP_001457565.1 CDS EcHS_A0826 NC_009800.1 832601 833884 R outer membrane lipoprotein that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; YbhC localizes to the cellular poles; member of pectinesterase; pectinesterase complement(832601..833884) Escherichia coli HS 5594744 YP_001457566.1 CDS EcHS_A0827 NC_009800.1 834036 834512 R YbhB; similar to rat and human kinase inhibitory proteins; kinase inhibitor protein complement(834036..834512) Escherichia coli HS 5595406 YP_001457567.1 CDS bioA NC_009800.1 834571 835860 R catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine-8-amino-7-oxononanoate aminotransferase complement(834571..835860) Escherichia coli HS 5595407 YP_001457568.1 CDS bioB NC_009800.1 835947 836987 D identified by similarity to SP:P12996; match to protein family HMM PF04055; match to protein family HMM PF06968; match to protein family HMM TIGR00433; biotin synthase 835947..836987 Escherichia coli HS 5595408 YP_001457569.1 CDS bioF NC_009800.1 836984 838138 D catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 836984..838138 Escherichia coli HS 5591502 YP_001457570.1 CDS bioC NC_009800.1 838125 838880 D methyltransferase; acyl carrier protein involved in an unidentified step in the synthesis of pimeloyl-CoA, a biotin precursor; member of the bio operon (bioABFCD); in Escherichia coli, bioC-null mutants require biotin for growth; biotin biosynthesis protein BioC 838125..838880 Escherichia coli HS 5591503 YP_001457571.1 CDS bioD NC_009800.1 838873 839550 D DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 838873..839550 Escherichia coli HS 5591504 YP_001457572.1 CDS uvrB NC_009800.1 840129 842150 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 840129..842150 Escherichia coli HS 5592044 YP_001457573.1 CDS EcHS_A0834 NC_009800.1 842342 843250 R identified by match to protein family HMM PF01933; match to protein family HMM TIGR01826; hypothetical protein complement(842342..843250) Escherichia coli HS 5592045 YP_001457574.1 CDS moaA NC_009800.1 843647 844636 D together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; molybdenum cofactor biosynthesis protein A 843647..844636 Escherichia coli HS 5592046 YP_001457575.1 CDS moaB NC_009800.1 844658 845170 D identified by similarity to SP:P30746; match to protein family HMM PF00994; match to protein family HMM TIGR00177; match to protein family HMM TIGR02667; molybdenum cofactor biosynthesis protein B 844658..845170 Escherichia coli HS 5593507 YP_001457576.1 CDS moaC NC_009800.1 845173 845658 D MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein C 845173..845658 Escherichia coli HS 5593508 YP_001457577.1 CDS moaD NC_009800.1 845651 845896 D catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin synthase small subunit 845651..845896 Escherichia coli HS 5593509 YP_001457578.1 CDS moaE NC_009800.1 845898 846350 D catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin synthase large subunit 845898..846350 Escherichia coli HS 5595165 YP_001457579.1 CDS EcHS_A0840 NC_009800.1 846487 847191 D ybhL; identified by match to protein family HMM PF01027; hypothetical protein 846487..847191 Escherichia coli HS 5595166 YP_001457580.1 CDS EcHS_A0841 NC_009800.1 847397 848110 D ybhM; identified by match to protein family HMM PF01027; hypothetical protein 847397..848110 Escherichia coli HS 5595167 YP_001457581.1 CDS EcHS_A0842 NC_009800.1 848146 849102 R ybhN; hypothetical protein complement(848146..849102) Escherichia coli HS 5593182 YP_001457582.1 CDS EcHS_A0843 NC_009800.1 849102 850343 R identified by similarity to SP:P0AA84; match to protein family HMM PF00614; cardiolipin synthase 2 complement(849102..850343) Escherichia coli HS 5593183 YP_001457583.1 CDS EcHS_A0844 NC_009800.1 850340 851101 R identified by match to protein family HMM PF03372; hypothetical protein complement(850340..851101) Escherichia coli HS 5593184 YP_001457584.1 CDS EcHS_A0845 NC_009800.1 851234 851644 D ybhQ; hypothetical protein 851234..851644 Escherichia coli HS 5593521 YP_001457585.1 CDS EcHS_A0846 NC_009800.1 851606 852712 R ybhR; identified by match to protein family HMM PF01061; ABC-2 type transporter permease complement(851606..852712) Escherichia coli HS 5593522 YP_001457586.1 CDS EcHS_A0847 NC_009800.1 852723 853856 R ybhS; identified by match to protein family HMM PF01061; ABC-2 type transporter permease complement(852723..853856) Escherichia coli HS 5593523 YP_001457587.1 CDS EcHS_A0848 NC_009800.1 853849 855585 R identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(853849..855585) Escherichia coli HS 5593334 YP_001457588.1 CDS EcHS_A0849 NC_009800.1 855578 856573 R identified by match to protein family HMM PF00529; hypothetical protein complement(855578..856573) Escherichia coli HS 5593335 YP_001457589.1 CDS EcHS_A0850 NC_009800.1 856576 857247 R identified by match to protein family HMM PF00440; match to protein family HMM PF09209; DNA-binding transcriptional regulator complement(856576..857247) Escherichia coli HS 5593336 YP_001457590.1 CDS EcHS_A0851 NC_009800.1 857476 858840 D this helicase is not essential cell growth; ATP-dependent RNA helicase RhlE 857476..858840 Escherichia coli HS 5593717 YP_001457591.1 CDS EcHS_A0852 NC_009800.1 858845 859006 R identified by glimmer; hypothetical protein complement(858845..859006) Escherichia coli HS 5593718 YP_001457592.1 CDS EcHS_A0854 NC_009800.1 859072 859554 R identified by similarity to GB:CAD72180.1; match to protein family HMM PF08719; match to protein family HMM TIGR02464; hypothetical protein complement(859072..859554) Escherichia coli HS 5593719 YP_001457593.1 CDS dinG NC_009800.1 859674 861824 D helicase involved in DNA repair and perhaps also replication; ATP-dependent DNA helicase DinG 859674..861824 Escherichia coli HS 5593992 YP_001457594.1 CDS EcHS_A0855 NC_009800.1 861852 862814 D identified by match to protein family HMM PF02885; glycosyl transferase 861852..862814 Escherichia coli HS 5593993 YP_001457595.1 CDS EcHS_A0856 NC_009800.1 862955 864040 D identified by similarity to PDB:2G8Y_A; match to protein family HMM PF02615; hypothetical protein 862955..864040 Escherichia coli HS 5593994 YP_001457596.1 CDS EcHS_A0857 NC_009800.1 864269 864529 R ybiJ; identified by match to protein family HMM PF07338; hypothetical protein complement(864269..864529) Escherichia coli HS 5594030 YP_001457597.1 CDS EcHS_A0858 NC_009800.1 864794 865060 R identified by match to protein family HMM PF01258; hypothetical protein complement(864794..865060) Escherichia coli HS 5594031 YP_001457598.1 CDS EcHS_A0859 NC_009800.1 865134 865811 R identified by match to protein family HMM PF03171; hydroxylase complement(865134..865811) Escherichia coli HS 5594032 YP_001457599.1 CDS fiu NC_009800.1 865853 868135 R Fiu; YbiL; porin involved in the uptake of iron complexed with catecholate siderophores (e.g. dihydroxybenzoylserine, dihydroxybenzoate) and beta lactam agents; Fiu interacts with TonB which provides the energy required for transport across the outer membrane; acts as a receptor for iron-siderophores and microcins E492, M, and H47; outer membrane protein; catecholate siderophore receptor Fiu complement(865853..868135) Escherichia coli HS 5595279 YP_001457600.1 CDS EcHS_A0861 NC_009800.1 868400 868804 R ybiM; identified by match to protein family HMM PF07338; hypothetical protein complement(868400..868804) Escherichia coli HS 5595280 YP_001457601.1 CDS EcHS_A0862 NC_009800.1 868855 869862 D ybiN; identified by match to protein family HMM PF05971; SAM-dependent methyltransferase 868855..869862 Escherichia coli HS 5595281 YP_001457602.1 CDS EcHS_A0863 NC_009800.1 869859 872084 R identified by match to protein family HMM PF00924; hypothetical protein complement(869859..872084) Escherichia coli HS 5594260 YP_001457603.1 CDS EcHS_A0864 NC_009800.1 872146 872328 R identified by glimmer; hypothetical protein complement(872146..872328) Escherichia coli HS 5594261 YP_001457604.1 CDS glnQ NC_009800.1 872345 873067 R similar to ATP-binding component of ABC transporters; glutamine ABC transporter ATP-binding protein complement(872345..873067) Escherichia coli HS 5594262 YP_001457605.1 CDS glnP NC_009800.1 873064 873723 R similar to permease component of ABC transporters; mutations impair ability of Escherichia coli to transport and utilize glutamine; glutamine ABC transporter permease complement(873064..873723) Escherichia coli HS 5594529 YP_001457606.1 CDS glnH NC_009800.1 873862 874608 R similar to periplasmic-binding component of ABC transporters; glutamine ABC transporter periplasmic protein complement(873862..874608) Escherichia coli HS 5594530 YP_001457607.1 CDS dps NC_009800.1 875012 875515 R binds DNA in a non-sequence-specific manner and is abundant during stationary phase; forms a DNA-protein crystal that protects DNA from damage; required for normal starvation response and long-term stationary viability; forms a homododecameric complex and sequesters iron which provides protection against oxidative damage; DNA starvation/stationary phase protection protein Dps complement(875012..875515) Escherichia coli HS 5594531 YP_001457608.1 CDS EcHS_A0869 NC_009800.1 875684 875782 R identified by glimmer; hypothetical protein complement(875684..875782) Escherichia coli HS 5594916 YP_001457609.1 CDS rhtA NC_009800.1 875813 876700 R identified by similarity to SP:P0AA67; match to protein family HMM PF00892; threonine and homoserine efflux system complement(875813..876700) Escherichia coli HS 5594917 YP_001457610.1 CDS ompX NC_009800.1 877053 877568 D OmpX; involved in cell adhesion; forms an eight-stranded antiparallel beta-barrel that protrudes from the cell surface; mutations in the gene increase cell-surface contact in fimbriated strains but decrease contact in nonfimbriated strains; outer membrane protein X 877053..877568 Escherichia coli HS 5594918 YP_001457611.1 CDS EcHS_A0872 NC_009800.1 877617 879200 R identified by match to protein family HMM PF00884; sulfatase complement(877617..879200) Escherichia coli HS 5594844 YP_001457612.1 CDS EcHS_A0873 NC_009800.1 879472 879600 R hypothetical protein complement(879472..879600) Escherichia coli HS 5594845 YP_001457613.1 CDS mntR NC_009800.1 879786 880253 D Transcriptional regulator that represses the manganese transporter MntH when manganese is present; manganese transport regulator MntR 879786..880253 Escherichia coli HS 5594846 YP_001457614.1 CDS EcHS_A0875 NC_009800.1 880250 881368 D ybiR; identified by match to protein family HMM PF03600; citrate transporter family protein 880250..881368 Escherichia coli HS 5594880 YP_001457615.1 CDS ybiS NC_009800.1 881427 882347 R identified by similarity to SP:P0AAX8; match to protein family HMM PF03734; hypothetical protein complement(881427..882347) Escherichia coli HS 5594881 YP_001457616.1 CDS EcHS_A0877 NC_009800.1 882566 884158 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 882566..884158 Escherichia coli HS 5594882 YP_001457617.1 CDS EcHS_A0878 NC_009800.1 884437 885417 D identified by match to protein family HMM PF01548; match to protein family HMM PF02371; IS621, transposase 884437..885417 Escherichia coli HS 5595431 YP_001457618.1 CDS EcHS_A0879 NC_009800.1 885678 886943 R ybiU; identified by match to protein family HMM PF07350; hypothetical protein complement(885678..886943) Escherichia coli HS 5595432 YP_001457619.1 CDS supH NC_009800.1 887095 887910 R identified by similarity to SP:P75792; match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; sugar phosphatase SupH complement(887095..887910) Escherichia coli HS 5595433 YP_001457620.1 CDS EcHS_A0881 NC_009800.1 888056 890488 R identified by match to protein family HMM PF01228; match to protein family HMM PF02901; match to protein family HMM TIGR01774; formate C-acetyltransferas complement(888056..890488) Escherichia coli HS 5594761 YP_001457621.1 CDS EcHS_A0882 NC_009800.1 890494 891393 R identified by match to protein family HMM PF04055; match to protein family HMM TIGR02494; glycyl-radical activating family protein complement(890494..891393) Escherichia coli HS 5594762 YP_001457622.1 CDS fsaA NC_009800.1 891524 892186 D similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 891524..892186 Escherichia coli HS 5594763 YP_001457623.1 CDS moeB NC_009800.1 892262 893011 R ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase; molybdopterin biosynthesis protein MoeB complement(892262..893011) Escherichia coli HS 5594342 YP_001457624.1 CDS moeA NC_009800.1 893011 894246 R is involved in the formation of active molybdenum cofactor and the chelation of molybdenum; molybdopterin biosynthesis protein MoeA complement(893011..894246) Escherichia coli HS 5594343 YP_001457625.1 CDS EcHS_A0886 NC_009800.1 894450 895415 D NULL; identified by similarity to SP:P37595; match to protein family HMM PF01112; L-asparaginase 894450..895415 Escherichia coli HS 5594344 YP_001457626.1 CDS gsiA NC_009800.1 895402 897273 D with GsiBCD is involved in glutathione import; GsiA contains 2 ATP-binding domains; glutathione transporter ATP-binding protein 895402..897273 Escherichia coli HS 5594813 YP_001457627.1 CDS gsiB NC_009800.1 897293 898831 D identified by similarity to SP:P75797; match to protein family HMM PF00496; glutathione ABC transporter periplasmic glutathione-binding protein GsiB 897293..898831 Escherichia coli HS 5594814 YP_001457628.1 CDS gsiC NC_009800.1 898849 899769 D identified by similarity to SP:P75798; match to protein family HMM PF00528; glutathione ABC transporter permease GsiC 898849..899769 Escherichia coli HS 5594815 YP_001457629.1 CDS gsiD NC_009800.1 899772 900683 D identified by similarity to SP:P75799; match to protein family HMM PF00528; glutathione ABC transporter permease GsiD 899772..900683 Escherichia coli HS 5593029 YP_001457630.1 CDS EcHS_A0891 NC_009800.1 900861 903209 D identified by match to protein family HMM PF00563; cyclic diguanylate phosphodiesterase domain-containing protein 900861..903209 Escherichia coli HS 5593030 YP_001457631.1 CDS EcHS_A0892 NC_009800.1 903217 904545 D yliF; identified by match to protein family HMM PF00990; match to protein family HMM TIGR00254; diguanylate cyclase 903217..904545 Escherichia coli HS 5593031 YP_001457632.1 CDS EcHS_A0893 NC_009800.1 904615 904944 R NULL; identified by match to protein family HMM PF01381; helix-turn-helix DNA-binding domain-containing protein complement(904615..904944) Escherichia coli HS 5594651 YP_001457633.1 CDS EcHS_A0894 NC_009800.1 904934 905320 R NULL; identified by match to protein family HMM PF06296; hypothetical protein complement(904934..905320) Escherichia coli HS 5594652 YP_001457634.1 CDS EcHS_A0895 NC_009800.1 905546 906871 R yliG; identified by match to protein family HMM PF00919; match to protein family HMM PF04055; match to protein family HMM TIGR00089; match to protein family HMM TIGR01125; MiaB-like tRNA modifying enzyme YliG complement(905546..906871) Escherichia coli HS 5594653 YP_001457635.1 CDS bssR NC_009800.1 907051 907467 D BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing; biofilm formation regulatory protein BssR 907051..907467 Escherichia coli HS 5594380 YP_001457636.1 CDS EcHS_A0899 NC_009800.1 908690 909316 R identified by match to protein family HMM PF00043; match to protein family HMM PF02798; glutathione S-transferase complement(908690..909316) Escherichia coli HS 5594382 YP_001457637.1 CDS dacC NC_009800.1 909563 910765 D penicillin-binding protein 6a; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase fraction C 909563..910765 Escherichia coli HS 5594671 YP_001457638.1 CDS deoR NC_009800.1 910812 911570 R identified by similarity to SP:P0ACK5; match to protein family HMM PF00455; match to protein family HMM PF08220; DNA-binding transcriptional repressor DeoR complement(910812..911570) Escherichia coli HS 5594672 YP_001457639.1 CDS EcHS_A0902 NC_009800.1 911628 912224 R ybjG; identified by match to protein family HMM PF01569; undecaprenyl pyrophosphate phosphatase complement(911628..912224) Escherichia coli HS 5594673 YP_001457640.1 CDS EcHS_A0903 NC_009800.1 912417 912524 D identified by glimmer; hypothetical protein 912417..912524 Escherichia coli HS 5594520 YP_001457641.1 CDS mdfA NC_009800.1 912509 913741 D identified by match to protein family HMM PF07690; multidrug translocase MdfA 912509..913741 Escherichia coli HS 5594521 YP_001457642.1 CDS EcHS_A0905 NC_009800.1 913782 914060 R ybjH; hypothetical protein complement(913782..914060) Escherichia coli HS 5594522 YP_001457643.1 CDS ybjI NC_009800.1 914152 914967 R identified by similarity to SP:P75809; match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; phosphatase YbjI complement(914152..914967) Escherichia coli HS 5594187 YP_001457644.1 CDS EcHS_A0907 NC_009800.1 914967 916175 R identified by match to protein family HMM PF07690; major facilitator transporter complement(914967..916175) Escherichia coli HS 5594188 YP_001457645.1 CDS EcHS_A0908 NC_009800.1 916259 916795 D identified by match to protein family HMM PF00440; TetR family transcriptional regulator 916259..916795 Escherichia coli HS 5594189 YP_001457646.1 CDS EcHS_A0909 NC_009800.1 917273 918304 R identified by match to protein family HMM PF00589; phage integrase site specific recombinase complement(917273..918304) Escherichia coli HS 5594426 YP_001457647.1 CDS EcHS_A0910 NC_009800.1 918417 918509 D identified by glimmer; hypothetical protein 918417..918509 Escherichia coli HS 5594427 YP_001457648.1 CDS EcHS_A0911 NC_009800.1 918700 919269 R identified by match to protein family HMM PF07022; bacteriophage CI repressor protein complement(918700..919269) Escherichia coli HS 5594428 YP_001457649.1 CDS EcHS_A0912 NC_009800.1 919395 919616 D hypothetical protein 919395..919616 Escherichia coli HS 5591418 YP_001457650.1 CDS EcHS_A0913 NC_009800.1 919649 920158 D identified by match to protein family HMM PF06892; phage regulatory protein CII (CP76) 919649..920158 Escherichia coli HS 5591419 YP_001457651.1 CDS EcHS_A0914 NC_009800.1 920330 920671 D identified by similarity to SP:P62534; hypothetical protein 920330..920671 Escherichia coli HS 5591420 YP_001457652.1 CDS EcHS_A0915 NC_009800.1 920739 920972 D hypothetical protein 920739..920972 Escherichia coli HS 5594332 YP_001457653.1 CDS EcHS_A0916 NC_009800.1 920972 921199 D identified by match to protein family HMM PF01258; match to protein family HMM TIGR02419; C4-type zinc finger DksA/TraR family protein 920972..921199 Escherichia coli HS 5594333 YP_001457654.1 CDS EcHS_A0917 NC_009800.1 921196 922053 D identified by similarity to SP:P21311; match to protein family HMM PF02086; match to protein family HMM TIGR00571; retron adenine methylase 921196..922053 Escherichia coli HS 5594334 YP_001457655.1 CDS EcHS_A0918 NC_009800.1 922050 924464 D identified by match to protein family HMM PF05840; replication gene A protein 922050..924464 Escherichia coli HS 5594276 YP_001457656.1 CDS EcHS_A0919 NC_009800.1 924619 924807 D identified by similarity to GB:CAD09430.1; hypothetical protein 924619..924807 Escherichia coli HS 5594277 YP_001457657.1 CDS EcHS_A0920 NC_009800.1 924818 925051 D identified by match to protein family HMM PF06183; dinI family protein 924818..925051 Escherichia coli HS 5594278 YP_001457658.1 CDS EcHS_A0921 NC_009800.1 925111 925842 D identified by glimmer; hypothetical protein 925111..925842 Escherichia coli HS 5594295 YP_001457659.1 CDS EcHS_A0922 NC_009800.1 926128 927519 D identified by glimmer; hypothetical protein 926128..927519 Escherichia coli HS 5594296 YP_001457660.1 CDS EcHS_A0923 NC_009800.1 927547 928572 R identified by match to protein family HMM PF04860; match to protein family HMM TIGR01540; PBSX family phage portal protein complement(927547..928572) Escherichia coli HS 5594297 YP_001457661.1 CDS EcHS_A0924 NC_009800.1 928572 930338 R identified by match to protein family HMM PF03237; match to protein family HMM PF06056; terminase, ATPase subunit complement(928572..930338) Escherichia coli HS 5594178 YP_001457662.1 CDS EcHS_A0925 NC_009800.1 930481 931314 D identified by match to protein family HMM PF05929; phage capsid scaffolding protein 930481..931314 Escherichia coli HS 5594179 YP_001457663.1 CDS EcHS_A0926 NC_009800.1 931331 932389 D identified by match to protein family HMM PF05125; match to protein family HMM TIGR01551; P2 family phage major capsid protein 931331..932389 Escherichia coli HS 5594180 YP_001457664.1 CDS EcHS_A0927 NC_009800.1 932393 933043 D identified by match to protein family HMM PF05944; terminase, endonuclease subunit 932393..933043 Escherichia coli HS 5594145 YP_001457665.1 CDS EcHS_A0928 NC_009800.1 933076 933603 D identified by match to protein family HMM PF05926; phage head completion protein 933076..933603 Escherichia coli HS 5594146 YP_001457666.1 CDS EcHS_A0929 NC_009800.1 933603 933806 D identified by match to protein family HMM PF05489; phage tail protein X 933603..933806 Escherichia coli HS 5594147 YP_001457667.1 CDS EcHS_A0930 NC_009800.1 933810 934025 D identified by similarity to GB:AAC45168.1; holin family protein 933810..934025 Escherichia coli HS 5595206 YP_001457668.1 CDS EcHS_A0931 NC_009800.1 934006 934518 D identified by match to protein family HMM PF00959; phage lysozyme 934006..934518 Escherichia coli HS 5595207 YP_001457669.1 CDS EcHS_A0932 NC_009800.1 934520 934897 D identified by similarity to GB:AAN79431.1; hypothetical protein 934520..934897 Escherichia coli HS 5595208 YP_001457670.1 CDS EcHS_A0933 NC_009800.1 934894 935322 D identified by similarity to SP:P51770; LysB protein 934894..935322 Escherichia coli HS 5593720 YP_001457671.1 CDS gpR NC_009800.1 935418 935849 D identified by match to protein family HMM PF06891; phage tail completion protein R 935418..935849 Escherichia coli HS 5593721 YP_001457672.1 CDS EcHS_A0935 NC_009800.1 935842 936288 D identified by match to protein family HMM PF05069; match to protein family HMM TIGR01635; phage virion morphogenesis protein 935842..936288 Escherichia coli HS 5593722 YP_001457673.1 CDS EcHS_A0936 NC_009800.1 936357 936935 D identified by similarity to SP:P31340; match to protein family HMM PF04717; match to protein family HMM TIGR01644; phage baseplate assembly protein V 936357..936935 Escherichia coli HS 5593555 YP_001457674.1 CDS EcHS_A0937 NC_009800.1 936932 937291 D identified by similarity to SP:P51768; match to protein family HMM PF04965; baseplate assembly protein W 936932..937291 Escherichia coli HS 5593556 YP_001457675.1 CDS EcHS_A0938 NC_009800.1 937278 938186 D identified by similarity to SP:P51767; match to protein family HMM PF04865; baseplate assembly protein J 937278..938186 Escherichia coli HS 5593557 YP_001457676.1 CDS EcHS_A0939 NC_009800.1 938179 938784 D identified by match to protein family HMM TIGR01634; phage tail protein I 938179..938784 Escherichia coli HS 5593843 YP_001457677.1 CDS EcHS_A0940 NC_009800.1 938781 940532 D identified by match to protein family HMM PF03406; tail fiber domain-containing protein 938781..940532 Escherichia coli HS 5593844 YP_001457678.1 CDS EcHS_A0941 NC_009800.1 940532 940945 D identified by similarity to SP:P03740; match to protein family HMM PF02413; tail fiber assembly protein 940532..940945 Escherichia coli HS 5593845 YP_001457679.1 CDS EcHS_A0942 NC_009800.1 941052 942224 D identified by similarity to SP:P22501; match to protein family HMM PF04984; major tail sheath protein 941052..942224 Escherichia coli HS 5593652 YP_001457680.1 CDS EcHS_A0943 NC_009800.1 942234 942749 D identified by match to protein family HMM PF04985; match to protein family HMM TIGR01611; phage major tail tube protein 942234..942749 Escherichia coli HS 5593653 YP_001457681.1 CDS EcHS_A0944 NC_009800.1 942804 943106 D identified by match to protein family HMM PF06158; phage tail protein E 942804..943106 Escherichia coli HS 5593654 YP_001457682.1 CDS EcHS_A0945 NC_009800.1 943121 943240 D phage tail protein P2 943121..943240 Escherichia coli HS 5592650 YP_001457683.1 CDS EcHS_A0946 NC_009800.1 943233 946310 D identified by match to protein family HMM TIGR01760; phage tail tape measure protein 943233..946310 Escherichia coli HS 5592651 YP_001457684.1 CDS EcHS_A0947 NC_009800.1 946310 946792 D identified by match to protein family HMM PF06995; phage protein gpU 946310..946792 Escherichia coli HS 5592652 YP_001457685.1 CDS EcHS_A0948 NC_009800.1 946789 947889 D identified by match to protein family HMM PF05954; phage late control gene D protein 946789..947889 Escherichia coli HS 5593117 YP_001457686.1 CDS EcHS_A0949 NC_009800.1 947980 948198 D identified by match to protein family HMM PF04606; phage transcriptional activator, Ogr/Delta 947980..948198 Escherichia coli HS 5593118 YP_001457687.1 CDS EcHS_A0950 NC_009800.1 948434 950119 R identified by match to protein family HMM PF02080; match to protein family HMM PF06826; match to protein family HMM TIGR01625; hypothetical protein complement(948434..950119) Escherichia coli HS 5593115 YP_001457688.1 CDS EcHS_A0951 NC_009800.1 950389 950766 D ybjM; hypothetical protein 950389..950766 Escherichia coli HS 5593116 YP_001457689.1 CDS grxA NC_009800.1 950796 951053 R functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase; glutaredoxin 1 complement(950796..951053) Escherichia coli HS 5593500 YP_001457690.1 CDS EcHS_A0953 NC_009800.1 951213 951500 D YbjC; located in the same operon as the nfsA gene; member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress; induced by paraquat; regulated by SoxS; unknown function; hypothetical protein 951213..951500 Escherichia coli HS 5593501 YP_001457691.1 CDS nfsA NC_009800.1 951484 952206 D NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds; nitroreductase A 951484..952206 Escherichia coli HS 5593502 YP_001457692.1 CDS rimK NC_009800.1 952267 953169 D responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6; ribosomal protein S6 modification protein 952267..953169 Escherichia coli HS 5595193 YP_001457693.1 CDS EcHS_A0956 NC_009800.1 953209 953733 D TPR repeat-containing protein 953209..953733 Escherichia coli HS 5595194 YP_001457694.1 CDS potF NC_009800.1 954084 955196 D identified by match to protein family HMM PF01547; putrescine transporter subunit: periplasmic-binding component of ABC superfamily 954084..955196 Escherichia coli HS 5595195 YP_001457695.1 CDS potG NC_009800.1 955291 956424 D part of the PotFGHI ATP-dependent putrescine transporter; putrescine transporter ATP-binding subunit 955291..956424 Escherichia coli HS 5592862 YP_001457696.1 CDS potH NC_009800.1 956434 957387 D identified by match to protein family HMM PF00528; putrescine transporter subunit: membrane component of ABC superfamily 956434..957387 Escherichia coli HS 5592863 YP_001457697.1 CDS potI NC_009800.1 957384 958229 D identified by match to protein family HMM PF00528; putrescine transporter subunit: membrane component of ABC superfamily 957384..958229 Escherichia coli HS 5592864 YP_001457698.1 CDS EcHS_A0961 NC_009800.1 958289 958777 D ybjO; hypothetical protein 958289..958777 Escherichia coli HS 5593321 YP_001457699.1 CDS rumB NC_009800.1 958818 959945 D RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA; 23S rRNA methyluridine methyltransferase 958818..959945 Escherichia coli HS 5593322 YP_001457700.1 CDS EcHS_A0963 NC_009800.1 959957 960169 D identified by glimmer; hypothetical protein 959957..960169 Escherichia coli HS 5593323 YP_001457701.1 CDS artJ NC_009800.1 960144 960875 R identified by match to protein family HMM PF00497; match to protein family HMM TIGR01096; arginine ABC transporter substrate-binding protein complement(960144..960875) Escherichia coli HS 5592205 YP_001457702.1 CDS artM NC_009800.1 961101 961769 R with ArtPQJI acts to transport arginine across the inner membrane; arginine transporter permease subunit ArtM complement(961101..961769) Escherichia coli HS 5592206 YP_001457703.1 CDS artQ NC_009800.1 961769 962485 R with ArtPMJI transports arginine across the inner membrane; arginine transporter permease subunit ArtQ complement(961769..962485) Escherichia coli HS 5592207 YP_001457704.1 CDS artI NC_009800.1 962492 963223 R identified by match to protein family HMM PF00497; match to protein family HMM TIGR01096; arginine ABC transporter substrate-binding protein complement(962492..963223) Escherichia coli HS 5593013 YP_001457705.1 CDS artP NC_009800.1 963241 963969 R With ArtMQJI transports arginine across the inner membrane; arginine transporter ATP-binding subunit complement(963241..963969) Escherichia coli HS 5593014 YP_001457706.1 CDS EcHS_A0969 NC_009800.1 964187 964702 R induced during stationary phase and by acivicin (a glutamine analog); regulated by Lrp and RpoS; lipoprotein complement(964187..964702) Escherichia coli HS 5593015 YP_001457707.1 CDS EcHS_A0970 NC_009800.1 964828 965151 D ybjQ; identified by match to protein family HMM PF01906; hypothetical protein 964828..965151 Escherichia coli HS 5593051 YP_001457708.1 CDS amiD NC_009800.1 965148 965978 D identified by similarity to SP:P75820; match to protein family HMM PF01510; N-acetylmuramoyl-L-alanine amidase 965148..965978 Escherichia coli HS 5593052 YP_001457709.1 CDS EcHS_A0972 NC_009800.1 965975 967024 R ybjS; identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF07993; NAD-dependent epimerase/dehydratase complement(965975..967024) Escherichia coli HS 5593053 YP_001457710.1 CDS EcHS_A0973 NC_009800.1 967087 968517 R ybjT; identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF05368; NAD dependent epimerase/dehydratase complement(967087..968517) Escherichia coli HS 5593153 YP_001457711.1 CDS ltaE NC_009800.1 968528 969529 R low- specificity; catalyzes the formation of acetaldehyde and glycine from L-threonine; acts on L-threonine, L-allo-threonine, L-threo-phenylserine, and L-erythro-phenylserine; L-threonine aldolase complement(968528..969529) Escherichia coli HS 5593154 YP_001457712.1 CDS poxB NC_009800.1 969566 971284 R catalyzes the formation of acetate from pyruvate; pyruvate dehydrogenase complement(969566..971284) Escherichia coli HS 5593155 YP_001457713.1 CDS hcr NC_009800.1 971417 972385 R identified by similarity to SP:P75824; match to protein family HMM PF00111; match to protein family HMM PF00175; match to protein family HMM PF00970; HCP oxidoreductase, NADH-dependent complement(971417..972385) Escherichia coli HS 5592729 YP_001457714.1 CDS hcp NC_009800.1 972397 974049 R catalyzes the reduction of hydroxylamine to ammonia and water; hydroxylamine reductase complement(972397..974049) Escherichia coli HS 5592730 YP_001457715.1 CDS EcHS_A0978 NC_009800.1 974193 975092 R identified by match to protein family HMM PF03956; hypothetical protein complement(974193..975092) Escherichia coli HS 5592731 YP_001457716.1 CDS aqpZ NC_009800.1 975587 976282 R porin involved in osmoregulation allowing water to move into and out of the cell in response to osmotic pressure; aquaporin Z complement(975587..976282) Escherichia coli HS 5593026 YP_001457717.1 CDS EcHS_A0980 NC_009800.1 976707 978365 D identified by similarity to GB:ABG68906.1; hypothetical protein 976707..978365 Escherichia coli HS 5593027 YP_001457718.1 CDS EcHS_A0981 NC_009800.1 978362 979354 R identified by match to protein family HMM PF04393; hypothetical protein complement(978362..979354) Escherichia coli HS 5593028 YP_001457719.1 CDS macA NC_009800.1 979469 980584 D confers macrolide resistance via active drug efflux; macrolide transporter subunit MacA 979469..980584 Escherichia coli HS 5593096 YP_001457720.1 CDS macB NC_009800.1 980581 982527 D with MacA is involved in the export of macrolide; macrolide transporter ATP-binding /permease 980581..982527 Escherichia coli HS 5593097 YP_001457721.1 CDS cspD NC_009800.1 982600 982824 R inhibits DNA replication at both initiation and elongation steps; stationary phase and starvation inducible; stationary phase/starvation inducible regulatory protein CspD complement(982600..982824) Escherichia coli HS 5593098 YP_001457722.1 CDS clpS NC_009800.1 983147 983467 D involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA; ATP-dependent Clp protease adaptor protein ClpS 983147..983467 Escherichia coli HS 5592938 YP_001457723.1 CDS clpA NC_009800.1 983498 985774 D ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease; directs protease to specific substrates; ATP-dependent Clp protease ATP-binding subunit 983498..985774 Escherichia coli HS 5592939 YP_001457724.1 CDS infA NC_009800.1 986573 986791 R stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 complement(986573..986791) Escherichia coli HS 5592887 YP_001457725.1 CDS aat NC_009800.1 987076 987780 R leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys; leucyl/phenylalanyl-tRNA--protein transferase complement(987076..987780) Escherichia coli HS 5592888 YP_001457726.1 CDS cudC NC_009800.1 987822 989543 R in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding component complement(987822..989543) Escherichia coli HS 5592884 YP_001457727.1 CDS cydD NC_009800.1 989544 991310 R in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding component complement(989544..991310) Escherichia coli HS 5592885 YP_001457728.1 CDS trxB NC_009800.1 991433 992398 R catalyzes the transfer of electrons from NADPH to thioredoxin; FAD/NAD(P) binding; thioredoxin reductase complement(991433..992398) Escherichia coli HS 5592886 YP_001457729.1 CDS EcHS_A0993 NC_009800.1 992467 992580 D identified by glimmer; hypothetical protein 992467..992580 Escherichia coli HS 5592913 YP_001457730.1 CDS lrp NC_009800.1 992943 993437 D mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system; leucine-responsive transcriptional regulator 992943..993437 Escherichia coli HS 5592914 YP_001457731.1 CDS ftsK NC_009800.1 993572 997561 D DNA-binding membrane protein required for chromosome resolution and partitioning; DNA translocase FtsK 993572..997561 Escherichia coli HS 5592915 YP_001457732.1 CDS lolA NC_009800.1 997716 998327 D participates with LolB in the incorporation of lipoprotein into the outer membrane; outer-membrane lipoprotein carrier protein 997716..998327 Escherichia coli HS 5592791 YP_001457733.1 CDS EcHS_A0997 NC_009800.1 998338 999681 D identified by similarity to SP:P0AAZ4; match to protein family HMM PF00004; recombination factor protein RarA 998338..999681 Escherichia coli HS 5592792 YP_001457734.1 CDS serS NC_009800.1 999772 1001064 D catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 999772..1001064 Escherichia coli HS 5592793 YP_001457735.1 CDS dmsA NC_009800.1 1001303 1003747 D identified by match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM PF04879; match to protein family HMM TIGR01409; match to protein family HMM TIGR02166; anaerobic dimethyl sulfoxide reductase, A subunit 1001303..1003747 Escherichia coli HS 5594963 YP_001457736.1 CDS dmsB2 NC_009800.1 1003758 1004375 D identified by similarity to SP:P18776; match to protein family HMM PF00037; match to protein family HMM TIGR02951; dimethylsulfoxide reductase, B subunit 1003758..1004375 Escherichia coli HS 5594964 YP_001457737.1 CDS dmsC1 NC_009800.1 1004377 1005240 D identified by similarity to SP:P18777; match to protein family HMM PF04976; anaerobic dimethyl sulfoxide reductase, C subunit 1004377..1005240 Escherichia coli HS 5594965 YP_001457738.1 CDS EcHS_A1003 NC_009800.1 1006071 1006184 R identified by glimmer; hypothetical protein complement(1006071..1006184) Escherichia coli HS 5592717 YP_001457739.1 CDS EcHS_A1004 NC_009800.1 1006215 1007363 D identified by match to protein family HMM PF07690; MFS family transporter protein 1006215..1007363 Escherichia coli HS 5592718 YP_001457740.1 CDS EcHS_A1005 NC_009800.1 1007381 1009003 D identified by match to protein family HMM PF00324; amino acid permease 1007381..1009003 Escherichia coli HS 5592122 YP_001457741.1 CDS EcHS_A1006 NC_009800.1 1009004 1009912 R identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator complement(1009004..1009912) Escherichia coli HS 5592123 YP_001457742.1 CDS pflA NC_009800.1 1010683 1011423 R activates pyruvate formate-lyase 1 under anaerobic conditions; pyruvate formate lyase-activating enzyme 1 complement(1010683..1011423) Escherichia coli HS 5591673 YP_001457743.1 CDS pflB2 NC_009800.1 1011615 1013897 R identified by similarity to SP:P09373; match to protein family HMM PF01228; match to protein family HMM PF02901; match to protein family HMM TIGR01255; formate acetyltransferase complement(1011615..1013897) Escherichia coli HS 5591674 YP_001457744.1 CDS EcHS_A1010 NC_009800.1 1013952 1014809 R identified by match to protein family HMM PF01226; match to protein family HMM TIGR00790; formate transporter complement(1013952..1014809) Escherichia coli HS 5591675 YP_001457745.1 CDS EcHS_A1011 NC_009800.1 1015215 1016975 R ycaO; identified by similarity to GB:AAP16417.1; match to protein family HMM PF02624; match to protein family HMM TIGR00702; hypothetical protein complement(1015215..1016975) Escherichia coli HS 5592483 YP_001457746.1 CDS EcHS_A1012 NC_009800.1 1017105 1017797 D ycaP; identified by match to protein family HMM PF04239; hypothetical protein 1017105..1017797 Escherichia coli HS 5592484 YP_001457747.1 CDS serC NC_009800.1 1017996 1019084 D catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase 1017996..1019084 Escherichia coli HS 5592485 YP_001457748.1 CDS aroA NC_009800.1 1019155 1020438 D catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 1019155..1020438 Escherichia coli HS 5591803 YP_001457749.1 CDS EcHS_A1015 NC_009800.1 1020607 1021371 D ycaL; identified by match to protein family HMM PF01435; M48B family peptidase 1020607..1021371 Escherichia coli HS 5591804 YP_001457750.1 CDS cmk NC_009800.1 1021544 1022227 D Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 1021544..1022227 Escherichia coli HS 5591805 YP_001457751.1 CDS rpsA NC_009800.1 1022338 1024011 D in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 1022338..1024011 Escherichia coli HS 5592480 YP_001457752.1 CDS ihfB NC_009800.1 1024171 1024455 D This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit beta 1024171..1024455 Escherichia coli HS 5592481 YP_001457753.1 CDS msbA NC_009800.1 1026959 1028707 D involved in the transport of lipid A across the inner membrane; lipid transporter ATP-binding/permease 1026959..1028707 Escherichia coli HS 5592454 YP_001457754.1 CDS lpxK NC_009800.1 1028704 1029690 D transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate; tetraacyldisaccharide 4'-kinase 1028704..1029690 Escherichia coli HS 5592455 YP_001457755.1 CDS EcHS_A1023 NC_009800.1 1029727 1030959 D ycaQ; identified by match to protein family HMM PF06224; hypothetical protein 1029727..1030959 Escherichia coli HS 5592456 YP_001457756.1 CDS EcHS_A1024 NC_009800.1 1031011 1031193 D ycaR; identified by similarity to GB:AAX64850.1; match to protein family HMM PF03966; hypothetical protein 1031011..1031193 Escherichia coli HS 5592549 YP_001457757.1 CDS kdsB NC_009800.1 1031190 1031936 D CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 1031190..1031936 Escherichia coli HS 5592550 YP_001457758.1 CDS EcHS_A1026 NC_009800.1 1032090 1032983 D ycbJ; hypothetical protein 1032090..1032983 Escherichia coli HS 5592551 YP_001457759.1 CDS EcHS_A1027 NC_009800.1 1032960 1033739 R ycbC; identified by match to protein family HMM PF02698; hypothetical protein complement(1032960..1033739) Escherichia coli HS 5595110 YP_001457760.1 CDS smtA NC_009800.1 1033875 1034660 D involved in cellular zinc and cadmium homeostasis by binding excess metal ions to its cysteine sulfurs and histidine nitrogens; expression of smtA in cyanobacteria is repressed by SmtB at low concentrations of zinc; NO elicits release of Zn ions from SmtA; metallothionein SmtA 1033875..1034660 Escherichia coli HS 5595111 YP_001457761.1 CDS mukF NC_009800.1 1034657 1035979 D acts with MukB and MukE to condense the chromosome and allow for segregation during cell division; condesin subunit F 1034657..1035979 Escherichia coli HS 5595112 YP_001457762.1 CDS mukE NC_009800.1 1035960 1036664 D acts with MukB and MukF to condense the chromosome and allow for segregation during cell division; condesin subunit E 1035960..1036664 Escherichia coli HS 5592391 YP_001457763.1 CDS mukB NC_009800.1 1036664 1041124 D SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects; cell division protein MukB 1036664..1041124 Escherichia coli HS 5592392 YP_001457764.1 CDS EcHS_A1032 NC_009800.1 1041385 1043232 D identified by match to protein family HMM PF01471; hypothetical protein 1041385..1043232 Escherichia coli HS 5592393 YP_001457765.1 CDS EcHS_A1033 NC_009800.1 1043413 1043961 D ycbK; identified by match to protein family HMM PF05951; match to protein family HMM PF08291; match to protein family HMM TIGR01409; Tat pathway signal sequence domain-containing protein 1043413..1043961 Escherichia coli HS 5591722 YP_001457766.1 CDS EcHS_A1034 NC_009800.1 1043988 1044635 D ycbL; identified by match to protein family HMM PF00753; metallo-beta-lactamase 1043988..1044635 Escherichia coli HS 5591723 YP_001457767.1 CDS EcHS_A1035 NC_009800.1 1044877 1045857 R identified by match to protein family HMM PF01548; match to protein family HMM PF02371; IS621, transposase complement(1044877..1045857) Escherichia coli HS 5591724 YP_001457768.1 CDS aspC NC_009800.1 1046136 1047326 R catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase complement(1046136..1047326) Escherichia coli HS 5591639 YP_001457769.1 CDS ompF NC_009800.1 1047511 1048599 R outer membrane porin F; 1a; Ia; b; outer membrane protein F complement(1047511..1048599) Escherichia coli HS 5591640 YP_001457770.1 CDS asnC NC_009800.1 1049201 1050601 R catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase complement(1049201..1050601) Escherichia coli HS 5591641 YP_001457771.1 CDS pncB NC_009800.1 1050770 1051972 R catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase complement(1050770..1051972) Escherichia coli HS 5592248 YP_001457772.1 CDS pepN NC_009800.1 1052238 1054850 D identified by match to protein family HMM PF01433; match to protein family HMM TIGR02414; aminopeptidase 1052238..1054850 Escherichia coli HS 5592250 YP_001457773.1 CDS ssuB NC_009800.1 1054893 1055660 R part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic substrate-binding subunit, SsuB the ATP-binding subunit and SsuC the permease; aliphatic sulfonates transport ATP-binding subunit complement(1054893..1055660) Escherichia coli HS 5591077 YP_001457774.1 CDS ssuC NC_009800.1 1055657 1056448 R part of the ABC type transport system for alkanesulfonate SsuABC; SsuB the ATP-binding subunit and SsuC the permease; alkanesulfonate transporter permease subunit complement(1055657..1056448) Escherichia coli HS 5591078 YP_001457775.1 CDS ssuD NC_009800.1 1056459 1057604 R catalyzes the release of sulfite from alkanesulfonates; alkanesulfonate monooxygenase complement(1056459..1057604) Escherichia coli HS 5591079 YP_001457776.1 CDS EcHS_A1045 NC_009800.1 1057601 1058602 R part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic subunit SsuB the ATP-binding subunit and SsuC the permease; alkanesulfonate transporter substrate-binding subunit complement(1057601..1058602) Escherichia coli HS 5591117 YP_001457777.1 CDS EcHS_A1046 NC_009800.1 1058553 1059128 R identified by match to protein family HMM PF02525; match to protein family HMM PF03358; NAD(P)H-dependent FMN reductase complement(1058553..1059128) Escherichia coli HS 5591118 YP_001457778.1 CDS EcHS_A1048 NC_009800.1 1060105 1060806 D identified by match to protein family HMM PF00345; match to protein family HMM PF02753; periplasmic pilus chaperone family protein 1060105..1060806 Escherichia coli HS 5591788 YP_001457779.1 CDS EcHS_A1049 NC_009800.1 1060831 1063431 D identified by similarity to SP:P30130; match to protein family HMM PF00577; outer membrane usher protein fimD-like protein 1060831..1063431 Escherichia coli HS 5591789 YP_001457780.1 CDS EcHS_A1050 NC_009800.1 1063422 1064492 D identified by match to protein family HMM PF00419; fimbrial protein 1063422..1064492 Escherichia coli HS 5591790 YP_001457781.1 CDS EcHS_A1051 NC_009800.1 1064504 1065046 D identified by match to protein family HMM PF00419; fimbrial protein 1064504..1065046 Escherichia coli HS 5591745 YP_001457782.1 CDS EcHS_A1052 NC_009800.1 1065054 1065569 D identified by match to protein family HMM PF00419; fimbrial protein 1065054..1065569 Escherichia coli HS 5591746 YP_001457783.1 CDS EcHS_A1053 NC_009800.1 1065535 1066272 D identified by match to protein family HMM PF00345; match to protein family HMM PF02753; putativi pili assembly chaperone 1065535..1066272 Escherichia coli HS 5591747 YP_001457784.1 CDS pyrD NC_009800.1 1066382 1067392 D catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 1066382..1067392 Escherichia coli HS 5592134 YP_001457785.1 CDS EcHS_A1055 NC_009800.1 1067530 1068108 D ycbW; identified by match to protein family HMM PF07126; hypothetical protein 1067530..1068108 Escherichia coli HS 5592135 YP_001457786.1 CDS EcHS_A1056 NC_009800.1 1068105 1069214 R identified by match to protein family HMM PF00111; match to protein family HMM PF03473; match to protein family HMM PF03476; MOSC domain-containing protein complement(1068105..1069214) Escherichia coli HS 5592136 YP_001457787.1 CDS rlmL NC_009800.1 1069458 1071566 D catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA; 23S rRNA m(2)G2445 methyltransferase 1069458..1071566 Escherichia coli HS 5595113 YP_001457788.1 CDS uup NC_009800.1 1071578 1073485 D Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth; ABC transporter ATPase component 1071578..1073485 Escherichia coli HS 5595114 YP_001457789.1 CDS pqiA NC_009800.1 1073615 1074868 D identified by similarity to SP:P43670; match to protein family HMM PF04403; match to protein family HMM TIGR00155; paraquat-inducible protein A 1073615..1074868 Escherichia coli HS 5595115 YP_001457790.1 CDS pqiB NC_009800.1 1074873 1076513 D identified by similarity to SP:P43671; match to protein family HMM PF02470; paraquat-inducible protein B 1074873..1076513 Escherichia coli HS 5592029 YP_001457791.1 CDS EcHS_A1061 NC_009800.1 1076510 1077073 D ymbA; identified by match to protein family HMM PF03886; hypothetical protein 1076510..1077073 Escherichia coli HS 5592030 YP_001457792.1 CDS rmf NC_009800.1 1077329 1077496 D identified by similarity to SP:P22986; match to protein family HMM PF04957; ribosome modulation factor 1077329..1077496 Escherichia coli HS 5592031 YP_001457793.1 CDS fabA NC_009800.1 1077566 1078084 R catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP; 3-hydroxydecanoyl-ACP dehydratase complement(1077566..1078084) Escherichia coli HS 5591914 YP_001457794.1 CDS EcHS_A1064 NC_009800.1 1078153 1079913 R S16 family peptidase complement(1078153..1079913) Escherichia coli HS 5591915 YP_001457795.1 CDS EcHS_A1065 NC_009800.1 1080099 1080551 D identified by match to protein family HMM PF06303; hypothetical protein 1080099..1080551 Escherichia coli HS 5591916 YP_001457796.1 CDS ompA NC_009800.1 1080627 1081667 R OmpA is believed to be a porin, involved in diffusion of nonspecific small solutes across the outer membrane. It is the most abundant integral protein of the outer membrane of E. coli, and it is known to play a role as a phage receptor, a mediator of F-factor dependent conjugation, and in maintaining the structural shape of the outer membrane; 3a; II*; G; d; outer membrane protein A complement(1080627..1081667) Escherichia coli HS 5591810 YP_001457797.1 CDS sulA NC_009800.1 1082024 1082533 R identified by match to protein family HMM PF03846; match to protein family HMM TIGR00623; SOS cell division inhibitor complement(1082024..1082533) Escherichia coli HS 5591811 YP_001457798.1 CDS EcHS_A1068 NC_009800.1 1082752 1083381 D yccR; identified by match to protein family HMM PF04993; match to protein family HMM PF04994; TfoX family protein 1082752..1083381 Escherichia coli HS 5591812 YP_001457799.1 CDS EcHS_A1069 NC_009800.1 1083344 1085506 R yccS; identified by match to protein family HMM PF05976; match to protein family HMM TIGR01666; match to protein family HMM TIGR01667; hypothetical protein complement(1083344..1085506) Escherichia coli HS 5591785 YP_001457800.1 CDS EcHS_A1070 NC_009800.1 1085516 1085962 R yccF; identified by match to protein family HMM PF03733; hypothetical protein complement(1085516..1085962) Escherichia coli HS 5591786 YP_001457801.1 CDS helD NC_009800.1 1086085 1088139 D catalyzes the ATP-dependent unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand; DNA helicase IV 1086085..1088139 Escherichia coli HS 5591787 YP_001457802.1 CDS mgsA NC_009800.1 1088171 1088629 R catalyzes the formation of methylglyoxal from glycerone phosphate; methylglyoxal synthase complement(1088171..1088629) Escherichia coli HS 5591725 YP_001457803.1 CDS EcHS_A1073 NC_009800.1 1088725 1089387 R yccT; hypothetical protein complement(1088725..1089387) Escherichia coli HS 5591726 YP_001457804.1 CDS EcHS_A1074 NC_009800.1 1089560 1089973 D identified by match to protein family HMM PF02629; CoA-binding protein 1089560..1089973 Escherichia coli HS 5591727 YP_001457805.1 CDS EcHS_A1075 NC_009800.1 1090018 1090335 R identified by similarity to SP:P0AB20; match to protein family HMM PF08755; match to protein family HMM TIGR02097; hemimethylated DNA-binding protein complement(1090018..1090335) Escherichia coli HS 5591600 YP_001457806.1 CDS EcHS_A1076 NC_009800.1 1090393 1091583 R identified by match to protein family HMM PF03602; hypothetical protein complement(1090393..1091583) Escherichia coli HS 5591601 YP_001457807.1 CDS tusE NC_009800.1 1091953 1092282 R transfers sulfur from TusBCD complex to MnmA; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein TusE complement(1091953..1092282) Escherichia coli HS 5591602 YP_001457808.1 CDS EcHS_A1078 NC_009800.1 1092373 1093032 R identified by match to protein family HMM PF01027; hypothetical protein complement(1092373..1093032) Escherichia coli HS 5591703 YP_001457809.1 CDS hyaA NC_009800.1 1093753 1094871 D identified by match to protein family HMM PF01058; match to protein family HMM PF08425; match to protein family HMM TIGR00391; match to protein family HMM TIGR01409; nickel-dependent hydrogenase 1, small subunit 1093753..1094871 Escherichia coli HS 5591705 YP_001457810.1 CDS hyaB NC_009800.1 1094868 1096661 D involved in hydrogen cycling during fermentative growth; hydrogenase 1 large subunit 1094868..1096661 Escherichia coli HS 5591424 YP_001457811.1 CDS hyaC NC_009800.1 1096680 1097387 D identified by match to protein family HMM PF01292; match to protein family HMM TIGR02125; hydrogenase 1 b-type cytochrome subunit 1096680..1097387 Escherichia coli HS 5591425 YP_001457812.1 CDS hyaD NC_009800.1 1097384 1097971 D HyaD; endopeptidase involved in the cleavage of the C-terminus end of HyaB (the large subunit of hydrogenase 1); hydrogenase 1 maturation protease 1097384..1097971 Escherichia coli HS 5591302 YP_001457813.1 CDS hyaE NC_009800.1 1097968 1098366 D involved in processing hydrogenases HyaA and HyaB; hydrogenase-1 operon protein HyaE 1097968..1098366 Escherichia coli HS 5591303 YP_001457814.1 CDS hyaF NC_009800.1 1098363 1099220 D identified by similarity to SP:P19932; match to protein family HMM PF04809; hydrogenase-1 operon protein HyaF 1098363..1099220 Escherichia coli HS 5591304 YP_001457815.1 CDS appC NC_009800.1 1099354 1100898 D identified by match to protein family HMM PF01654; cytochrome bd-II oxidase, subunit I 1099354..1100898 Escherichia coli HS 5591421 YP_001457816.1 CDS appB NC_009800.1 1100910 1102046 D identified by match to protein family HMM PF02322; match to protein family HMM TIGR00203; cytochrome bd-II oxidase, subunit II 1100910..1102046 Escherichia coli HS 5591422 YP_001457817.1 CDS EcHS_A1088 NC_009800.1 1102059 1102151 D yccB; identified by match to protein family HMM PF08173; cyd operon protein YccB 1102059..1102151 Escherichia coli HS 5591423 YP_001457818.1 CDS appA NC_009800.1 1102231 1103529 D identified by similarity to SP:P07102; match to protein family HMM PF00328; phosphoanhydride phosphorylase 1102231..1103529 Escherichia coli HS 5594974 YP_001457819.1 CDS etk1 NC_009800.1 1103644 1105824 R yccC; identified by similarity to SP:P38134; match to protein family HMM PF02706; cryptic autophosphorylating protein tyrosine kinase Etk complement(1103644..1105824) Escherichia coli HS 5594975 YP_001457820.1 CDS etp NC_009800.1 1105844 1106290 R Etk and Etp are a tyrosine kinase-tyrosine phosphatase pair, etp dephosphorylates etk; phosphotyrosine-protein phosphatase complement(1105844..1106290) Escherichia coli HS 5594976 YP_001457821.1 CDS yccZ NC_009800.1 1106278 1107438 R identified by similarity to SP:P0A934; match to protein family HMM PF02563; outer membrane lipoprotein, group 4 capsule (G4C) polysaccharide complement(1106278..1107438) Escherichia coli HS 5591526 YP_001457822.1 CDS ymcB NC_009800.1 1109559 1110305 R ymcB; identified by similarity to SP:P75883; match to protein family HMM PF06251; group 4 capsule (G4C) polysaccharide, YmcB complement(1109559..1110305) Escherichia coli HS 5591528 YP_001457823.1 CDS ymcC NC_009800.1 1110302 1110946 R identified by similarity to SP:P75884; group 4 capsule (G4C) polysaccharide, lipoprotein YmcC complement(1110302..1110946) Escherichia coli HS 5591440 YP_001457824.1 CDS EcHS_A1097 NC_009800.1 1111053 1111376 R identified by similarity to SP:P75885; inner membrane protein complement(1111053..1111376) Escherichia coli HS 5591441 YP_001457825.1 CDS EcHS_A1098 NC_009800.1 1111800 1112012 R identified by match to protein family HMM PF00313; cold shock DNA-binding protein complement(1111800..1112012) Escherichia coli HS 5591442 YP_001457826.1 CDS EcHS_A1099 NC_009800.1 1112298 1112510 D identified by match to protein family HMM PF00313; cold shock protein CspG 1112298..1112510 Escherichia coli HS 5591333 YP_001457827.1 CDS EcHS_A1100 NC_009800.1 1112684 1112914 D cold shock gene 1112684..1112914 Escherichia coli HS 5591334 YP_001457828.1 CDS EcHS_A1101 NC_009800.1 1112919 1113092 R identified by glimmer; hypothetical protein complement(1112919..1113092) Escherichia coli HS 5591335 YP_001457829.1 CDS EcHS_A1102 NC_009800.1 1113125 1114198 R yccM; identified by match to protein family HMM PF00037; 4Fe-4S ferredoxin complement(1113125..1114198) Escherichia coli HS 5591375 YP_001457830.1 CDS EcHS_A1103 NC_009800.1 1114072 1114236 R identified by glimmer; hypothetical protein complement(1114072..1114236) Escherichia coli HS 5591376 YP_001457831.1 CDS torS NC_009800.1 1114270 1117014 R Member of the two-component regulatory system torS/torR involved in the anaerobic utilization of trimethylamine-N-oxide; hybrid sensory histidine kinase TorS complement(1114270..1117014) Escherichia coli HS 5591377 YP_001457832.1 CDS torT NC_009800.1 1117097 1118125 D periplasmic sensory protein associated with the TorRS two-component regulatory system; TMAO reductase system periplasmic protein TorT 1117097..1118125 Escherichia coli HS 5592687 YP_001457833.1 CDS torR NC_009800.1 1118098 1118790 R response regulator in two-component regulatory system with TorS; involved in regulation of trimethylamine N-oxide reductase genes; DNA-binding transcriptional regulator TorR complement(1118098..1118790) Escherichia coli HS 5592688 YP_001457834.1 CDS torC NC_009800.1 1118920 1120092 D identified by similarity to SP:P33226; match to protein family HMM PF03264; match to protein family HMM TIGR02162; cytochrome c-type protein torC 1118920..1120092 Escherichia coli HS 5592689 YP_001457835.1 CDS torA NC_009800.1 1120092 1122638 D identified by similarity to SP:P33225; match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM TIGR00509; match to protein family HMM TIGR01409; match to protein family HMM TIGR02164; trimethylamine-N-oxide reductase 1120092..1122638 Escherichia coli HS 5592889 YP_001457836.1 CDS torD NC_009800.1 1122635 1123234 D TorD; involved in the biogenesis of torA; acts on torA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor; chaperone protein TorD 1122635..1123234 Escherichia coli HS 5592890 YP_001457837.1 CDS EcHS_A1110 NC_009800.1 1123274 1123384 R identified by glimmer; hypothetical protein complement(1123274..1123384) Escherichia coli HS 5592891 YP_001457838.1 CDS cbpM NC_009800.1 1123386 1123691 R with CpbA modulates the activity of the dnaK chaperone system; interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA; chaperone-modulator protein CbpM complement(1123386..1123691) Escherichia coli HS 5594393 YP_001457839.1 CDS cbpA NC_009800.1 1123691 1124611 R functional analog of DnaJ; co-chaperone with DnaK, molecular chaperone in an adaptive response to environmental stresses other than heat shock; curved DNA-binding protein CbpA complement(1123691..1124611) Escherichia coli HS 5594394 YP_001457840.1 CDS EcHS_A1113 NC_009800.1 1124872 1126128 D NULL; identified by similarity to SP:P36661; hypothetical protein 1124872..1126128 Escherichia coli HS 5594395 YP_001457841.1 CDS EcHS_A1114 NC_009800.1 1126179 1126280 D identified by glimmer; hypothetical protein 1126179..1126280 Escherichia coli HS 5595221 YP_001457842.1 CDS agp NC_009800.1 1126421 1127662 D identified by similarity to SP:P19926; match to protein family HMM PF00328; glucose-1-phosphatase/inositol phosphatase 1126421..1127662 Escherichia coli HS 5595222 YP_001457843.1 CDS EcHS_A1116 NC_009800.1 1127882 1128109 R yccJ; hypothetical protein complement(1127882..1128109) Escherichia coli HS 5595223 YP_001457844.1 CDS wrbA NC_009800.1 1128130 1128726 R stationary phase that binds TrpR repressor; TrpR binding protein WrbA complement(1128130..1128726) Escherichia coli HS 5594923 YP_001457845.1 CDS EcHS_A1118 NC_009800.1 1129099 1129272 D identified by similarity to GB:BAA35782.1; hypothetical protein 1129099..1129272 Escherichia coli HS 5594924 YP_001457846.1 CDS EcHS_A1119 NC_009800.1 1129285 1129377 D identified by glimmer; hypothetical protein 1129285..1129377 Escherichia coli HS 5594925 YP_001457847.1 CDS EcHS_A1120 NC_009800.1 1129590 1130570 D identified by match to protein family HMM PF01548; match to protein family HMM PF02371; IS621, transposase 1129590..1130570 Escherichia coli HS 5595294 YP_001457848.1 CDS EcHS_A1121 NC_009800.1 1130809 1132137 R identified by similarity to SP:P75892; match to protein family HMM PF00860; match to protein family HMM TIGR00801; purine permease ycdG complement(1130809..1132137) Escherichia coli HS 5595295 YP_001457849.1 CDS EcHS_A1122 NC_009800.1 1132158 1132652 R identified by similarity to SP:P75893; match to protein family HMM PF01613; flavin reductase rutF complement(1132158..1132652) Escherichia coli HS 5595296 YP_001457850.1 CDS EcHS_A1123 NC_009800.1 1132663 1133253 R identified by similarity to SP:P75894; match to protein family HMM PF00881; hypothetical protein complement(1132663..1133253) Escherichia coli HS 5595353 YP_001457851.1 CDS EcHS_A1124 NC_009800.1 1133263 1134063 R identified by similarity to SP:P75895; match to protein family HMM PF00561; rutD protein complement(1133263..1134063) Escherichia coli HS 5595354 YP_001457852.1 CDS EcHS_A1125 NC_009800.1 1134071 1134457 R identified by similarity to SP:P0AFQ5; match to protein family HMM PF01042; rutC protein complement(1134071..1134457) Escherichia coli HS 5595355 YP_001457853.1 CDS EcHS_A1126 NC_009800.1 1134469 1135164 R identified by similarity to SP:P75897; match to protein family HMM PF00857; isochorismatase, rutB complement(1134469..1135164) Escherichia coli HS 5594517 YP_001457854.1 CDS EcHS_A1127 NC_009800.1 1135161 1136342 R identified by similarity to SP:P75898; match to protein family HMM PF00296; monooxygenase rutA complement(1135161..1136342) Escherichia coli HS 5594518 YP_001457855.1 CDS rutR NC_009800.1 1136541 1137179 D identified by similarity to SP:P0ACU2; match to protein family HMM PF00440; match to protein family HMM PF08362; transcriptional regulator RutR 1136541..1137179 Escherichia coli HS 5594519 YP_001457856.1 CDS putA NC_009800.1 1137219 1141181 R proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichai coli this protein also self-regulates transcription via a DNA-binding domain at the N-terminus; forms dimers and is a peripherally membrane-associated protein; trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase complement(1137219..1141181) Escherichia coli HS 5593337 YP_001457857.1 CDS EcHS_A1130 NC_009800.1 1141333 1141524 R identified by glimmer; hypothetical protein complement(1141333..1141524) Escherichia coli HS 5593338 YP_001457858.1 CDS putP NC_009800.1 1141604 1143112 D identified by match to protein family HMM PF00474; match to protein family HMM TIGR00813; match to protein family HMM TIGR02121; sodium/proline symporter 1141604..1143112 Escherichia coli HS 5593339 YP_001457859.1 CDS EcHS_A1132 NC_009800.1 1143654 1144484 D identified by match to protein family HMM PF03239; match to protein family HMM TIGR00145; iron permease 1143654..1144484 Escherichia coli HS 5594899 YP_001457860.1 CDS EcHS_A1133 NC_009800.1 1144542 1145669 D ycdO; identified by match to protein family HMM PF04302; hypothetical protein 1144542..1145669 Escherichia coli HS 5594900 YP_001457861.1 CDS EcHS_A1134 NC_009800.1 1145675 1146946 D ycdB; identified by match to protein family HMM PF04261; match to protein family HMM TIGR01409; match to protein family HMM TIGR01412; match to protein family HMM TIGR01413; Tat-translocated enzyme 1145675..1146946 Escherichia coli HS 5594901 YP_001457862.1 CDS phoH NC_009800.1 1147291 1148355 D identified by similarity to SP:P0A9K1; match to protein family HMM PF02562; hypothetical protein 1147291..1148355 Escherichia coli HS 5592289 YP_001457863.1 CDS pgaD NC_009800.1 1148405 1148818 R ycdP; biofilm PGA synthesis protein PgaD complement(1148405..1148818) Escherichia coli HS 5592290 YP_001457864.1 CDS pgaC NC_009800.1 1148820 1150145 R predicted polysaccharide polymerase involved in biofilm formation; required for the synthesis of the beta-1,6-N-acetylglucosamine polysaccharide; N-glycosyltransferase PgaC complement(1148820..1150145) Escherichia coli HS 5592291 YP_001457865.1 CDS pgaB NC_009800.1 1150138 1152156 R ycdR; identified by match to protein family HMM PF01522; biofilm PGA synthesis lipoprotein pgaB complement(1150138..1152156) Escherichia coli HS 5593558 YP_001457866.1 CDS EcHS_A1140 NC_009800.1 1153256 1153759 R identified by match to protein family HMM PF03400; IS1, transposase orfB complement(1153256..1153759) Escherichia coli HS 5593560 YP_001457867.1 CDS EcHS_A1141 NC_009800.1 1153678 1153953 R identified by match to protein family HMM PF03811; IS1, transposase orfA complement(1153678..1153953) Escherichia coli HS 5591349 YP_001457868.1 CDS EcHS_A1143 NC_009800.1 1155880 1157310 D ycdT; identified by match to protein family HMM PF00990; match to protein family HMM TIGR00254; diguanylate cyclase 1155880..1157310 Escherichia coli HS 5591351 YP_001457869.1 CDS EcHS_A1146 NC_009800.1 1158214 1158513 R identified by similarity to GB:AAZ76519.1; match to protein family HMM PF01527; IS3, transposase orfA complement(1158214..1158513) Escherichia coli HS 5592744 YP_001457870.1 CDS EcHS_A1147 NC_009800.1 1158563 1158922 D identified by glimmer; hypothetical protein 1158563..1158922 Escherichia coli HS 5592745 YP_001457871.1 CDS EcHS_A1148 NC_009800.1 1158919 1159905 D ycdU; hypothetical protein 1158919..1159905 Escherichia coli HS 5593232 YP_001457872.1 CDS EcHS_A1150 NC_009800.1 1160648 1160761 R identified by glimmer; hypothetical protein complement(1160648..1160761) Escherichia coli HS 5593234 YP_001457873.1 CDS EcHS_A1151 NC_009800.1 1160782 1161720 D identified by match to protein family HMM PF02826; D-isomer specific 2-hydroxyacid dehydrogenase 1160782..1161720 Escherichia coli HS 5591305 YP_001457874.1 CDS EcHS_A1152 NC_009800.1 1161775 1162512 D ycdX; identified by match to protein family HMM PF02811; hydrolase 1161775..1162512 Escherichia coli HS 5591306 YP_001457875.1 CDS EcHS_A1153 NC_009800.1 1162536 1163090 D identified by match to protein family HMM PF06192; chaperone TorD 1162536..1163090 Escherichia coli HS 5594633 YP_001457876.1 CDS EcHS_A1154 NC_009800.1 1163192 1163683 D ycdZ; identified by match to protein family HMM PF06496; hypothetical protein 1163192..1163683 Escherichia coli HS 5594634 YP_001457877.1 CDS csgG NC_009800.1 1163747 1164580 R identified by match to protein family HMM PF03783; curli production assembly/transport subunit CsgG complement(1163747..1164580) Escherichia coli HS 5594635 YP_001457878.1 CDS csgF NC_009800.1 1164607 1165023 R nucleator protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgF complement(1164607..1165023) Escherichia coli HS 5591465 YP_001457879.1 CDS csgE NC_009800.1 1165048 1165437 R chaperone-like protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgE complement(1165048..1165437) Escherichia coli HS 5591466 YP_001457880.1 CDS csgD NC_009800.1 1165442 1166092 R activates the csgBA and csgDEFG operons involved in biofilm formation; DNA-binding transcriptional regulator CsgD complement(1165442..1166092) Escherichia coli HS 5591467 YP_001457881.1 CDS EcHS_A1159 NC_009800.1 1166559 1166753 R identified by glimmer; hypothetical protein complement(1166559..1166753) Escherichia coli HS 5591636 YP_001457882.1 CDS csgB NC_009800.1 1166847 1167302 D CsgB; functions as a nucleator in the assembly of curli (coiled surface structures) on the cell surface; curlin minor subunit 1166847..1167302 Escherichia coli HS 5591637 YP_001457883.1 CDS csgA NC_009800.1 1167343 1167798 D identified by similarity to SP:P28307; match to protein family HMM PF07012; cryptic curlin major subunit 1167343..1167798 Escherichia coli HS 5591638 YP_001457884.1 CDS csgC NC_009800.1 1167857 1168189 D involved in autoagglutination of curliated cells; not involved in production of curli fibers; autoagglutination protein 1167857..1168189 Escherichia coli HS 5591920 YP_001457885.1 CDS EcHS_A1163 NC_009800.1 1168227 1168730 R identified by match to protein family HMM PF03400; IS1, transposase orfB complement(1168227..1168730) Escherichia coli HS 5591921 YP_001457886.1 CDS EcHS_A1164 NC_009800.1 1168649 1168924 R identified by match to protein family HMM PF03811; IS1, transposase orfA complement(1168649..1168924) Escherichia coli HS 5591922 YP_001457887.1 CDS EcHS_A1165 NC_009800.1 1169087 1169398 D ymdA; hypothetical protein 1169087..1169398 Escherichia coli HS 5591564 YP_001457888.1 CDS EcHS_A1166 NC_009800.1 1169493 1170026 D identified by match to protein family HMM PF01661; hypothetical protein 1169493..1170026 Escherichia coli HS 5591565 YP_001457889.1 CDS EcHS_A1167 NC_009800.1 1170019 1171449 D identified by match to protein family HMM PF00614; phopholipase D 1170019..1171449 Escherichia coli HS 5591566 YP_001457890.1 CDS mdoC NC_009800.1 1171457 1172614 R required for the transfer of succinyl residues to the glucan backbone; glucans biosynthesis protein complement(1171457..1172614) Escherichia coli HS 5591800 YP_001457891.1 CDS EcHS_A1169 NC_009800.1 1172659 1172802 R identified by glimmer; hypothetical protein complement(1172659..1172802) Escherichia coli HS 5591801 YP_001457892.1 CDS mdoG NC_009800.1 1173008 1174543 D involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan; glucan biosynthesis protein G 1173008..1174543 Escherichia coli HS 5591802 YP_001457893.1 CDS mdoH NC_009800.1 1174536 1177079 D necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space; glucosyltransferase MdoH 1174536..1177079 Escherichia coli HS 5592167 YP_001457894.1 CDS EcHS_A1172 NC_009800.1 1177088 1177261 D identified by glimmer; hypothetical protein 1177088..1177261 Escherichia coli HS 5592168 YP_001457895.1 CDS EcHS_A1173 NC_009800.1 1177252 1177479 D yceK; identified by match to protein family HMM PF07119; hypothetical protein 1177252..1177479 Escherichia coli HS 5592169 YP_001457896.1 CDS msyB NC_009800.1 1177480 1177854 R hypothetical protein complement(1177480..1177854) Escherichia coli HS 5595063 YP_001457897.1 CDS mdtG NC_009800.1 1177937 1179166 R Confers resistance to fosfomycin and deoxycholate; drug efflux system protein MdtG complement(1177937..1179166) Escherichia coli HS 5595064 YP_001457898.1 CDS EcHS_A1176 NC_009800.1 1179196 1179300 D identified by glimmer; hypothetical protein 1179196..1179300 Escherichia coli HS 5595065 YP_001457899.1 CDS htrB NC_009800.1 1179338 1180258 R Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase complement(1179338..1180258) Escherichia coli HS 5592125 YP_001457900.1 CDS EcHS_A1178 NC_009800.1 1180483 1181535 D yceA; identified by match to protein family HMM PF00581; hypothetical protein 1180483..1181535 Escherichia coli HS 5592126 YP_001457901.1 CDS yceI NC_009800.1 1181577 1182152 R identified by similarity to SP:P0A8X2; match to protein family HMM PF04264; hypothetical protein complement(1181577..1182152) Escherichia coli HS 5592127 YP_001457902.1 CDS EcHS_A1180 NC_009800.1 1182156 1182722 R identified by match to protein family HMM PF01292; nickel-dependent hydrogenase b-type cytochrome subunit complement(1182156..1182722) Escherichia coli HS 5595140 YP_001457903.1 CDS EcHS_A1181 NC_009800.1 1182983 1183096 R yceO; identified by similarity to RF:NP_460130.1; hypothetical protein complement(1182983..1183096) Escherichia coli HS 5595141 YP_001457904.1 CDS solA NC_009800.1 1183144 1184262 R catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids; N-methyltryptophan oxidase complement(1183144..1184262) Escherichia coli HS 5595142 YP_001457905.1 CDS bssS NC_009800.1 1184377 1184634 R BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing; biofilm formation regulatory protein BssS complement(1184377..1184634) Escherichia coli HS 5594406 YP_001457906.1 CDS dinI NC_009800.1 1184921 1185166 R identified by similarity to SP:P0ABR4; match to protein family HMM PF06183; DNA damage-inducible protein I complement(1184921..1185166) Escherichia coli HS 5594407 YP_001457907.1 CDS pyrC NC_009800.1 1185240 1186286 R catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase complement(1185240..1186286) Escherichia coli HS 5594408 YP_001457908.1 CDS EcHS_A1186 NC_009800.1 1186392 1186952 R yceB; identified by match to protein family HMM PF07273; hypothetical protein complement(1186392..1186952) Escherichia coli HS 5594532 YP_001457909.1 CDS grxB NC_009800.1 1187086 1187733 R cofactor involved in the reduction of disulfides; glutaredoxin 2 complement(1187086..1187733) Escherichia coli HS 5594533 YP_001457910.1 CDS mdtH NC_009800.1 1187797 1189005 R Confers resistance to norfloxacin and enoxacin; multidrug resistance protein MdtH complement(1187797..1189005) Escherichia coli HS 5594534 YP_001457911.1 CDS rimJ NC_009800.1 1189241 1189825 D identified by similarity to SP:P0A948; match to protein family HMM PF00583; ribosomal-protein-S5-alanine N-acetyltransferase 1189241..1189825 Escherichia coli HS 5595403 YP_001457912.1 CDS EcHS_A1190 NC_009800.1 1189836 1190483 D yceH; identified by match to protein family HMM PF04337; hypothetical protein 1189836..1190483 Escherichia coli HS 5595404 YP_001457913.1 CDS EcHS_A1191 NC_009800.1 1190485 1191408 D identified by match to protein family HMM PF01408; match to protein family HMM PF02894; oxidoreductase 1190485..1191408 Escherichia coli HS 5595405 YP_001457914.1 CDS mviN NC_009800.1 1191518 1193053 D identified by match to protein family HMM PF03023; match to protein family HMM TIGR01695; integral membrane protein MviN 1191518..1193053 Escherichia coli HS 5592067 YP_001457915.1 CDS flgN NC_009800.1 1193093 1193509 R identified by match to protein family HMM PF05130; flagellar synthesis protein FlgN complement(1193093..1193509) Escherichia coli HS 5592068 YP_001457916.1 CDS flgM NC_009800.1 1193514 1193807 R regulates the flagellar specific sigma28 transcription factor; anti-sigma28 factor FlgM complement(1193514..1193807) Escherichia coli HS 5592069 YP_001457917.1 CDS flgA NC_009800.1 1193883 1194542 R required for the assembly of the flagellar basal body P-ring; flagellar basal body P-ring biosynthesis protein FlgA complement(1193883..1194542) Escherichia coli HS 5594957 YP_001457918.1 CDS flgB NC_009800.1 1194698 1195114 D with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella; flagellar basal-body rod protein FlgB 1194698..1195114 Escherichia coli HS 5594958 YP_001457919.1 CDS flgC NC_009800.1 1195118 1195522 D with FlgF and B makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgC 1195118..1195522 Escherichia coli HS 5594959 YP_001457920.1 CDS flgD NC_009800.1 1195534 1196229 D acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production; flagellar basal body rod modification protein 1195534..1196229 Escherichia coli HS 5592586 YP_001457921.1 CDS flgE NC_009800.1 1196254 1197462 D the hook connects flagellar basal body to the flagellar filament; flagellar hook protein FlgE 1196254..1197462 Escherichia coli HS 5592587 YP_001457922.1 CDS flgF NC_009800.1 1197482 1198237 D FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgF 1197482..1198237 Escherichia coli HS 5592588 YP_001457923.1 CDS flgG NC_009800.1 1198409 1199191 D makes up the distal portion of the flagellar basal body rod; flagellar basal body rod protein FlgG 1198409..1199191 Escherichia coli HS 5595412 YP_001457924.1 CDS flgH NC_009800.1 1199244 1199942 D part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod; flagellar basal body L-ring protein 1199244..1199942 Escherichia coli HS 5595413 YP_001457925.1 CDS flgI NC_009800.1 1199954 1201051 D part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum; flagellar basal body P-ring biosynthesis protein FlgA 1199954..1201051 Escherichia coli HS 5595414 YP_001457926.1 CDS flgJ NC_009800.1 1201051 1201992 D Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space; flagellar rod assembly protein/muramidase FlgJ 1201051..1201992 Escherichia coli HS 5595088 YP_001457927.1 CDS flgK NC_009800.1 1202058 1203701 D with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook; flagellar hook-associated protein FlgK 1202058..1203701 Escherichia coli HS 5595089 YP_001457928.1 CDS flgL NC_009800.1 1203713 1204666 D with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of this and other flagellar genes; flagellar hook-associated protein FlgL 1203713..1204666 Escherichia coli HS 5595090 YP_001457929.1 CDS rne NC_009800.1 1204862 1208047 R bifunctional ribonuclease E/endoribonuclease/RNA-binding protein/RNA degradosome binding protein; forms part of the membrane-associated degradosome complex along with PNPase, RhlB, and enolase; ribonuclease E complement(1204862..1208047) Escherichia coli HS 5592997 YP_001457930.1 CDS rluC NC_009800.1 1208620 1209579 D catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA; 23S rRNA pseudouridylate synthase C 1208620..1209579 Escherichia coli HS 5592998 YP_001457931.1 CDS maf2 NC_009800.1 1209691 1210314 R Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein complement(1209691..1210314) Escherichia coli HS 5592999 YP_001457932.1 CDS EcHS_A1210 NC_009800.1 1210474 1210995 D yceD; identified by match to protein family HMM PF02620; hypothetical protein 1210474..1210995 Escherichia coli HS 5594912 YP_001457933.1 CDS rpmF NC_009800.1 1211047 1211220 D some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 1211047..1211220 Escherichia coli HS 5592895 YP_001457934.1 CDS plsX NC_009800.1 1211301 1212371 D involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; glycerol-3-phosphate acyltransferase PlsX 1211301..1212371 Escherichia coli HS 5592896 YP_001457935.1 CDS fabH NC_009800.1 1212439 1213392 D FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase 1212439..1213392 Escherichia coli HS 5592897 YP_001457936.1 CDS fabD NC_009800.1 1213408 1214337 D identified by match to protein family HMM PF00698; match to protein family HMM TIGR00128; malonyl CoA-acyl carrier protein transacylase 1213408..1214337 Escherichia coli HS 5594662 YP_001457937.1 CDS fabG NC_009800.1 1214350 1215084 D catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 1214350..1215084 Escherichia coli HS 5594663 YP_001457938.1 CDS acpP NC_009800.1 1215295 1215531 D carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 1215295..1215531 Escherichia coli HS 5594664 YP_001457939.1 CDS fabF NC_009800.1 1215619 1216860 D FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 1215619..1216860 Escherichia coli HS 5593683 YP_001457940.1 CDS pabC NC_009800.1 1216980 1217789 D catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate; 4-amino-4-deoxychorismate lyase 1216980..1217789 Escherichia coli HS 5593684 YP_001457941.1 CDS EcHS_A1219 NC_009800.1 1217792 1218814 D identified by match to protein family HMM PF02618; match to protein family HMM TIGR00247; hypothetical protein 1217792..1218814 Escherichia coli HS 5593685 YP_001457942.1 CDS tmk NC_009800.1 1218804 1219445 D catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 1218804..1219445 Escherichia coli HS 5592070 YP_001457943.1 CDS holB NC_009800.1 1219442 1220446 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 1219442..1220446 Escherichia coli HS 5592071 YP_001457944.1 CDS EcHS_A1222 NC_009800.1 1220457 1221254 D identified by match to protein family HMM PF01026; match to protein family HMM TIGR00010; metallodependent hydrolase 1220457..1221254 Escherichia coli HS 5592072 YP_001457945.1 CDS ptsG NC_009800.1 1221549 1222982 D phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; glucose-specific PTS system IIBC components 1221549..1222982 Escherichia coli HS 5594574 YP_001457946.1 CDS fhuE NC_009800.1 1223042 1225231 R identified by similarity to SP:P16869; match to protein family HMM PF00593; match to protein family HMM PF07715; match to protein family HMM TIGR01783; ferric-rhodotorulic acid outer membrane transporter complement(1223042..1225231) Escherichia coli HS 5594575 YP_001457947.1 CDS EcHS_A1225 NC_009800.1 1225264 1225434 R hypothetical protein complement(1225264..1225434) Escherichia coli HS 5594576 YP_001457948.1 CDS hinT NC_009800.1 1225565 1225924 D ycfF; identified by similarity to SP:P0ACE7; match to protein family HMM PF01230; purine nucleoside phosphoramidase 1225565..1225924 Escherichia coli HS 5593796 YP_001457949.1 CDS EcHS_A1227 NC_009800.1 1225927 1226304 D ycfL; identified by match to protein family HMM PF07233; lipoprotein 1225927..1226304 Escherichia coli HS 5593797 YP_001457950.1 CDS EcHS_A1228 NC_009800.1 1226318 1226959 D ycfM; identified by match to protein family HMM TIGR02722; lipoprotein 1226318..1226959 Escherichia coli HS 5593798 YP_001457951.1 CDS thiK NC_009800.1 1226940 1227764 D catalyzes the phosphorylation of thiamine to thiamine phosphate; thiamine kinase 1226940..1227764 Escherichia coli HS 5592035 YP_001457952.1 CDS nagZ NC_009800.1 1227775 1228800 D hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides; beta-hexosaminidase 1227775..1228800 Escherichia coli HS 5592036 YP_001457953.1 CDS EcHS_A1231 NC_009800.1 1228823 1229365 D ycfP; identified by match to protein family HMM PF05728; hypothetical protein 1228823..1229365 Escherichia coli HS 5592037 YP_001457954.1 CDS ndh NC_009800.1 1229773 1231077 D identified by similarity to SP:P00393; match to protein family HMM PF00070; match to protein family HMM PF01266; match to protein family HMM PF07992; NADH dehydrogenase 1229773..1231077 Escherichia coli HS 5595181 YP_001457955.1 CDS EcHS_A1233 NC_009800.1 1231304 1231843 D ycfJ; identified by match to protein family HMM PF05433; hypothetical protein 1231304..1231843 Escherichia coli HS 5595182 YP_001457956.1 CDS EcHS_A1234 NC_009800.1 1231905 1232615 R ycfQ; identified by match to protein family HMM PF00440; TetR family transcriptional regulator complement(1231905..1232615) Escherichia coli HS 5595183 YP_001457957.1 CDS EcHS_A1235 NC_009800.1 1232778 1233035 D ycfR; identified by match to protein family HMM PF07338; hypothetical protein 1232778..1233035 Escherichia coli HS 5592969 YP_001457958.1 CDS EcHS_A1236 NC_009800.1 1233118 1234080 R identified by match to protein family HMM PF01476; match to protein family HMM PF03734; LysM/ErfK/YbiS/YcfS/YnhG family protein complement(1233118..1234080) Escherichia coli HS 5592970 YP_001457959.1 CDS mfd NC_009800.1 1234224 1237670 R identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF02559; match to protein family HMM PF03461; match to protein family HMM PF04851; match to protein family HMM TIGR00580; transcription-repair coupling factor complement(1234224..1237670) Escherichia coli HS 5592971 YP_001457960.1 CDS EcHS_A1238 NC_009800.1 1237798 1238871 R ycfT; identified by match to protein family HMM PF01757; hypothetical protein complement(1237798..1238871) Escherichia coli HS 5593093 YP_001457961.1 CDS lolD NC_009800.1 1240325 1241026 D outer membrane specific; part of transporter complex lolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone; lipoprotein transporter ATP-binding subunit 1240325..1241026 Escherichia coli HS 5593094 YP_001457962.1 CDS lolE NC_009800.1 1241026 1242270 D part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolE 1241026..1242270 Escherichia coli HS 5593095 YP_001457963.1 CDS nagK NC_009800.1 1242299 1243210 D catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine; N-acetyl-D-glucosamine kinase 1242299..1243210 Escherichia coli HS 5593314 YP_001457964.1 CDS npdA NC_009800.1 1243226 1244065 D Modulates the activities of several enzymes which are inactive in their acetylated form; NAD-dependent deacetylase 1243226..1244065 Escherichia coli HS 5593315 YP_001457965.1 CDS potD NC_009800.1 1244202 1245248 R can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotD is a periplasmic component that binds the substrate; spermidine/putrescine ABC transporter periplasmic substrate-binding protein complement(1244202..1245248) Escherichia coli HS 5593316 YP_001457966.1 CDS potC NC_009800.1 1245245 1246039 R can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component; spermidine/putrescine ABC transporter membrane protein complement(1245245..1246039) Escherichia coli HS 5593561 YP_001457967.1 CDS potB NC_009800.1 1246036 1246893 R can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component; spermidine/putrescine ABC transporter membrane protein complement(1246036..1246893) Escherichia coli HS 5593562 YP_001457968.1 CDS potA NC_009800.1 1246877 1248013 R functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase; putrescine/spermidine ABC transporter ATPase complement(1246877..1248013) Escherichia coli HS 5593563 YP_001457969.1 CDS pepT NC_009800.1 1248263 1249489 D catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T 1248263..1249489 Escherichia coli HS 5593353 YP_001457970.1 CDS EcHS_A1248 NC_009800.1 1249538 1250659 R identified by match to protein family HMM PF08007; cupin family protein complement(1249538..1250659) Escherichia coli HS 5593354 YP_001457971.1 CDS phoQ NC_009800.1 1250735 1252195 R identified by similarity to SP:P23837; match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM PF08918; sensor protein PhoQ complement(1250735..1252195) Escherichia coli HS 5593355 YP_001457972.1 CDS phoP NC_009800.1 1252195 1252866 R response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress; DNA-binding transcriptional regulator PhoP complement(1252195..1252866) Escherichia coli HS 5593868 YP_001457973.1 CDS purB NC_009800.1 1253035 1254405 R Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase complement(1253035..1254405) Escherichia coli HS 5593869 YP_001457974.1 CDS EcHS_A1252 NC_009800.1 1254409 1255050 R HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis; hypothetical protein complement(1254409..1255050) Escherichia coli HS 5593870 YP_001457975.1 CDS mnmA NC_009800.1 1255086 1256192 R catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA complement(1255086..1256192) Escherichia coli HS 5594040 YP_001457976.1 CDS EcHS_A1254 NC_009800.1 1256246 1256707 R identified by match to protein family HMM PF00293; NUDIX family hydrolase complement(1256246..1256707) Escherichia coli HS 5594041 YP_001457977.1 CDS rluE NC_009800.1 1256717 1257370 R catalyzes the formation of pseudouridine from uracil-2457 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase E complement(1256717..1257370) Escherichia coli HS 5594042 YP_001457978.1 CDS icd NC_009800.1 1257542 1258792 D Converts isocitrate to alpha ketoglutarate; isocitrate dehydrogenase 1257542..1258792 Escherichia coli HS 5594410 YP_001457979.1 CDS EcHS_A1257 NC_009800.1 1259921 1260325 R ycgX; identified by match to protein family HMM PF07166; hypothetical protein complement(1259921..1260325) Escherichia coli HS 5594411 YP_001457980.1 CDS mlrA NC_009800.1 1260546 1261277 R identified by similarity to SP:P33358; match to protein family HMM PF00376; transcriptional regulator mlrA complement(1260546..1261277) Escherichia coli HS 5594412 YP_001457981.1 CDS EcHS_A1259 NC_009800.1 1261482 1262693 R ycgF; identified by match to protein family HMM PF00563; match to protein family HMM PF04940; BLUF/cyclic diguanylate phosphodiesterase domain-containing protein complement(1261482..1262693) Escherichia coli HS 5594893 YP_001457982.1 CDS EcHS_A1260 NC_009800.1 1263333 1264145 R identified by similarity to GB:AAP17067.1; match to protein family HMM PF00665; ISEhe3, transposase orfB complement(1263333..1264145) Escherichia coli HS 5594894 YP_001457983.1 CDS EcHS_A1261 NC_009800.1 1264202 1264480 R identified by match to protein family HMM PF01527; ISEhe3, transposase orfA complement(1264202..1264480) Escherichia coli HS 5594895 YP_001457984.1 CDS EcHS_A1262 NC_009800.1 1264818 1265084 D ymgB; hypothetical protein 1264818..1265084 Escherichia coli HS 5594639 YP_001457985.1 CDS EcHS_A1263 NC_009800.1 1265197 1265445 D ymgC; hypothetical protein 1265197..1265445 Escherichia coli HS 5594640 YP_001457986.1 CDS EcHS_A1264 NC_009800.1 1265735 1267300 D identified by match to protein family HMM PF00563; cyclic diguanylate phosphodiesterase domain-containing protein 1265735..1267300 Escherichia coli HS 5594641 YP_001457987.1 CDS EcHS_A1265 NC_009800.1 1267432 1267650 D ymgF; hypothetical protein 1267432..1267650 Escherichia coli HS 5595494 YP_001457988.1 CDS EcHS_A1266 NC_009800.1 1267743 1267886 D identified by glimmer; hypothetical protein 1267743..1267886 Escherichia coli HS 5595495 YP_001457989.1 CDS EcHS_A1267 NC_009800.1 1268050 1269570 D identified by glimmer; hypothetical protein 1268050..1269570 Escherichia coli HS 5595496 YP_001457990.1 CDS EcHS_A1269 NC_009800.1 1270754 1271083 R ymgD; identified by glimmer; hypothetical protein complement(1270754..1271083) Escherichia coli HS 5591401 YP_001457991.1 CDS EcHS_A1270 NC_009800.1 1271093 1271437 R identified by similarity to GB:ABB13223.1; hypothetical protein complement(1271093..1271437) Escherichia coli HS 5591402 YP_001457992.1 CDS EcHS_A1271 NC_009800.1 1271439 1271612 R identified by glimmer; hypothetical protein complement(1271439..1271612) Escherichia coli HS 5594491 YP_001457993.1 CDS EcHS_A1272 NC_009800.1 1271859 1271978 D identified by glimmer; hypothetical protein 1271859..1271978 Escherichia coli HS 5594492 YP_001457994.1 CDS EcHS_A1273 NC_009800.1 1272144 1272356 D identified by glimmer; hypothetical protein 1272144..1272356 Escherichia coli HS 5594493 YP_001457995.1 CDS minE NC_009800.1 1272728 1272994 R works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell; cell division topological specificity factor MinE complement(1272728..1272994) Escherichia coli HS 5593020 YP_001457996.1 CDS minD NC_009800.1 1272998 1273810 R ATPase; with MinC inhibits cell division by blocking formation of the polar Z ring septums; cell division inhibitor MinD complement(1272998..1273810) Escherichia coli HS 5593021 YP_001457997.1 CDS minC NC_009800.1 1273834 1274544 R blocks the formation of polar Z-ring septums; septum formation inhibitor complement(1273834..1274544) Escherichia coli HS 5593022 YP_001457998.1 CDS EcHS_A1277 NC_009800.1 1275049 1275417 D ycgJ; identified by match to protein family HMM PF05666; fels-1 prophage protein 1275049..1275417 Escherichia coli HS 5593304 YP_001457999.1 CDS EcHS_A1278 NC_009800.1 1275520 1275921 R ycgK; identified by match to protein family HMM PF04151; pre-peptidase C-terminal domain-containing protein complement(1275520..1275921) Escherichia coli HS 5593305 YP_001458000.1 CDS EcHS_A1279 NC_009800.1 1276163 1276456 D ycgL; identified by match to protein family HMM PF05166; hypothetical protein 1276163..1276456 Escherichia coli HS 5593306 YP_001458001.1 CDS EcHS_A1280 NC_009800.1 1276528 1277187 D identified by match to protein family HMM PF01557; hypothetical protein 1276528..1277187 Escherichia coli HS 5594681 YP_001458002.1 CDS EcHS_A1281 NC_009800.1 1277264 1277725 D ycgN; identified by similarity to GB:ABB61366.1; match to protein family HMM PF03692; hypothetical protein 1277264..1277725 Escherichia coli HS 5594682 YP_001458003.1 CDS EcHS_A1285 NC_009800.1 1278970 1279080 R identified by glimmer; hypothetical protein complement(1278970..1279080) Escherichia coli HS 5595339 YP_001458004.1 CDS umuD NC_009800.1 1279206 1279625 D binds with UmuC protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuD 1279206..1279625 Escherichia coli HS 5595341 YP_001458005.1 CDS umuC NC_009800.1 1279625 1280893 D binds processed UmuD protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuC 1279625..1280893 Escherichia coli HS 5593627 YP_001458006.1 CDS dsbB NC_009800.1 1280939 1281469 R disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein; disulfide bond formation protein B complement(1280939..1281469) Escherichia coli HS 5593628 YP_001458007.1 CDS nhaB NC_009800.1 1281615 1283156 R involved in regulation of intracellular pH under alkaline conditions; sodium/proton antiporter complement(1281615..1283156) Escherichia coli HS 5594107 YP_001458008.1 CDS fadR NC_009800.1 1283377 1284096 D Multifunctional regulator of fatty acid metabolism; fatty acid metabolism regulator 1283377..1284096 Escherichia coli HS 5594108 YP_001458009.1 CDS EcHS_A1291 NC_009800.1 1284148 1285680 R identified by match to protein family HMM PF04293; SpoVR family protein complement(1284148..1285680) Escherichia coli HS 5594109 YP_001458010.1 CDS dadA NC_009800.1 1286010 1287308 D catalyzes the oxidative deamination of D-amino acids; D-amino acid dehydrogenase small subunit 1286010..1287308 Escherichia coli HS 5594390 YP_001458011.1 CDS dadX NC_009800.1 1287318 1288388 D catabolic enzyme, converts L-alanine to D-alanine which is then oxidized to pyruvate by dadA; alanine racemase 1287318..1288388 Escherichia coli HS 5594391 YP_001458012.1 CDS cvrA NC_009800.1 1288774 1290510 R the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli; potassium/proton antiporter complement(1288774..1290510) Escherichia coli HS 5594392 YP_001458013.1 CDS ldcA NC_009800.1 1290605 1291519 R catalyzes the release of D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine; L,D-carboxypeptidase A complement(1290605..1291519) Escherichia coli HS 5593596 YP_001458014.1 CDS mltE NC_009800.1 1291505 1292230 D identified by similarity to SP:P76009; match to protein family HMM PF01464; membrane-bound lytic murein transglycosylase E 1291505..1292230 Escherichia coli HS 5593597 YP_001458015.1 CDS EcHS_A1297 NC_009800.1 1292232 1292966 R identified by match to protein family HMM PF07238; match to protein family HMM PF07317; type IV pilus assembly protein PilZ complement(1292232..1292966) Escherichia coli HS 5593598 YP_001458016.1 CDS EcHS_A1298 NC_009800.1 1293167 1293421 D identified by match to protein family HMM PF04226; transglycosylase-associated protein 1293167..1293421 Escherichia coli HS 5592546 YP_001458017.1 CDS EcHS_A1299 NC_009800.1 1293599 1294039 D ycgY; identified by similarity to GB:ABB66472.1; hypothetical protein 1293599..1294039 Escherichia coli HS 5592547 YP_001458018.1 CDS treA NC_009800.1 1294118 1295815 R periplasmic; catalyzes the hydrolysis of trehalose to glucose which can then be imported into the cell; trehalase complement(1294118..1295815) Escherichia coli HS 5592548 YP_001458019.1 CDS EcHS_A1300 NC_009800.1 1295829 1295975 D hypothetical protein 1295829..1295975 Escherichia coli HS 5593671 YP_001458020.1 CDS dhaM NC_009800.1 1296135 1297553 R phosphotransferaese subunit; phosphorylates dihydroxyacetone; dihydroxyacetone kinase subunit M complement(1296135..1297553) Escherichia coli HS 5593672 YP_001458021.1 CDS EcHS_A1303 NC_009800.1 1297564 1298196 R with DhaK and DhaM catalyzes the phosphorylation of dihydroxyacetone; dihydroxyacetone kinase ADP-binding subunit complement(1297564..1298196) Escherichia coli HS 5593673 YP_001458022.1 CDS dhaK NC_009800.1 1298207 1299277 R with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase; dihydroxyacetone kinase subunit DhaK complement(1298207..1299277) Escherichia coli HS 5593170 YP_001458023.1 CDS dhaR NC_009800.1 1299505 1301424 D Positively regulates the dhaKLM operon from a sigma-70 promoter; DNA-binding transcriptional regulator DhaR 1299505..1301424 Escherichia coli HS 5593171 YP_001458024.1 CDS EcHS_A1306 NC_009800.1 1301524 1304391 R identified by match to protein family HMM PF03212; match to protein family HMM PF03797; match to protein family HMM TIGR01414; outer membrane autotransporter complement(1301524..1304391) Escherichia coli HS 5593172 YP_001458025.1 CDS EcHS_A1307 NC_009800.1 1304736 1304915 D identified by similarity to GB:AAZ88642.1; hypothetical protein 1304736..1304915 Escherichia coli HS 5594067 YP_001458026.1 CDS engD NC_009800.1 1305160 1306251 R translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD complement(1305160..1306251) Escherichia coli HS 5594068 YP_001458027.1 CDS pth NC_009800.1 1306368 1306952 R Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase complement(1306368..1306952) Escherichia coli HS 5594069 YP_001458028.1 CDS EcHS_A1310 NC_009800.1 1307230 1307508 D YchH; transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria; ychH presents a class II promoter to bind CRP; unknown function; hypothetical protein 1307230..1307508 Escherichia coli HS 5592230 YP_001458029.1 CDS ychM NC_009800.1 1307563 1309215 R role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport; sulfate transporter YchM complement(1307563..1309215) Escherichia coli HS 5592231 YP_001458030.1 CDS prs NC_009800.1 1309367 1310314 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase complement(1309367..1310314) Escherichia coli HS 5592232 YP_001458031.1 CDS ipk NC_009800.1 1310465 1311316 R An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase complement(1310465..1311316) Escherichia coli HS 5593920 YP_001458032.1 CDS lolB NC_009800.1 1311316 1311939 R Incorporates lipoproteins in the outer membrane after they are released by the LolA protein; molecular chaperone LolB complement(1311316..1311939) Escherichia coli HS 5593921 YP_001458033.1 CDS hemA NC_009800.1 1312153 1313409 D catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 1312153..1313409 Escherichia coli HS 5593922 YP_001458034.1 CDS prfA NC_009800.1 1313451 1314533 D recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 1313451..1314533 Escherichia coli HS 5593790 YP_001458035.1 CDS hemK NC_009800.1 1314533 1315366 D HemK; PrmC; transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 1314533..1315366 Escherichia coli HS 5593791 YP_001458036.1 CDS EcHS_A1318 NC_009800.1 1315363 1315755 D ychQ; identified by match to protein family HMM PF04247; transcriptional regulator 1315363..1315755 Escherichia coli HS 5593792 YP_001458037.1 CDS sirB1 NC_009800.1 1315759 1316568 D ychA; identified by similarity to SP:P20101; transcriptional regulator 1315759..1316568 Escherichia coli HS 5593914 YP_001458038.1 CDS kdsA NC_009800.1 1316604 1317458 D catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 1316604..1317458 Escherichia coli HS 5593915 YP_001458039.1 CDS EcHS_A1321 NC_009800.1 1317509 1317730 D identified by glimmer; hypothetical protein 1317509..1317730 Escherichia coli HS 5593916 YP_001458040.1 CDS EcHS_A1322 NC_009800.1 1318140 1318274 R identified by similarity to GB:AAZ88629.1; hypothetical protein complement(1318140..1318274) Escherichia coli HS 5593436 YP_001458041.1 CDS EcHS_A1323 NC_009800.1 1318675 1318809 R identified by similarity to GB:AAZ88629.1; hypothetical protein complement(1318675..1318809) Escherichia coli HS 5593437 YP_001458042.1 CDS EcHS_A1324 NC_009800.1 1319187 1320287 R identified by similarity to SP:P31801; match to protein family HMM PF01699; match to protein family HMM TIGR00846; calcium/sodium:proton antiporter complement(1319187..1320287) Escherichia coli HS 5593438 YP_001458043.1 CDS chaB NC_009800.1 1320557 1320787 D in Escherichia coli this protein ly regulates the sodium/proton (also pH-independent calcium/proton) antiporter chaA; has weak affinity for calcium and magnesium ions; cation transport regulator 1320557..1320787 Escherichia coli HS 5593911 YP_001458044.1 CDS EcHS_A1326 NC_009800.1 1320924 1321640 D identified by match to protein family HMM PF04752; chaC protein 1320924..1321640 Escherichia coli HS 5593912 YP_001458045.1 CDS EcHS_A1327 NC_009800.1 1321684 1322037 R ychN; identified by match to protein family HMM PF02635; dsrE family protein complement(1321684..1322037) Escherichia coli HS 5593913 YP_001458046.1 CDS EcHS_A1328 NC_009800.1 1322159 1322290 D identified by glimmer; hypothetical protein 1322159..1322290 Escherichia coli HS 5593229 YP_001458047.1 CDS EcHS_A1329 NC_009800.1 1322223 1323617 D hypothetical protein 1322223..1323617 Escherichia coli HS 5593230 YP_001458048.1 CDS narL NC_009800.1 1323618 1324268 R two-component response regulator NarL; phosphorylated by NarQ; activates transcription of nitrate and nitrite reductase genes and represses transcription of fumarate reductase; transcriptional regulator NarL complement(1323618..1324268) Escherichia coli HS 5593231 YP_001458049.1 CDS narX NC_009800.1 1324261 1326057 R identified by similarity to SP:P10956; match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM PF07730; nitrate/nitrite sensor protein NarX complement(1324261..1326057) Escherichia coli HS 5593632 YP_001458050.1 CDS EcHS_A1332 NC_009800.1 1326083 1326301 D identified by glimmer; hypothetical protein 1326083..1326301 Escherichia coli HS 5593633 YP_001458051.1 CDS narK NC_009800.1 1326396 1327787 D identified by match to protein family HMM PF07690; match to protein family HMM TIGR00886; nitrite extrusion protein 1 1326396..1327787 Escherichia coli HS 5593634 YP_001458052.1 CDS narG NC_009800.1 1328303 1332046 D identified by match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM TIGR01580; nitrate reductase, alpha subunit 1328303..1332046 Escherichia coli HS 5593514 YP_001458053.1 CDS narH NC_009800.1 1332043 1333581 D identified by similarity to SP:P11349; match to protein family HMM PF00037; match to protein family HMM TIGR01660; nitrate reductase, beta subunit 1332043..1333581 Escherichia coli HS 5593515 YP_001458054.1 CDS narJ NC_009800.1 1333578 1334288 D identified by similarity to SP:P0AF26; match to protein family HMM PF02613; match to protein family HMM TIGR00684; nitrate reductase molybdenum cofactor assembly chaperone 1333578..1334288 Escherichia coli HS 5593516 YP_001458055.1 CDS narI2 NC_009800.1 1334288 1334965 D identified by similarity to SP:P11350; match to protein family HMM PF02665; match to protein family HMM TIGR00351; respiratory nitrate reductase, gamma subunit 1334288..1334965 Escherichia coli HS 5593711 YP_001458056.1 CDS purU NC_009800.1 1336040 1336882 R produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; formyltetrahydrofolate deformylase complement(1336040..1336882) Escherichia coli HS 5593487 YP_001458057.1 CDS EcHS_A1341 NC_009800.1 1336932 1337390 R ychJ; identified by match to protein family HMM PF02810; hypothetical protein complement(1336932..1337390) Escherichia coli HS 5593606 YP_001458058.1 CDS EcHS_A1342 NC_009800.1 1337503 1338408 D ychK; identified by match to protein family HMM PF01734; hypothetical protein 1337503..1338408 Escherichia coli HS 5593607 YP_001458059.1 CDS EcHS_A1343 NC_009800.1 1338500 1339513 D identified by match to protein family HMM PF00072; response regulator of RpoS 1338500..1339513 Escherichia coli HS 5593608 YP_001458060.1 CDS galU NC_009800.1 1339715 1340623 D together with GalF subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; UTP-glucose-1-phosphate uridylyltransferase 1339715..1340623 Escherichia coli HS 5593609 YP_001458061.1 CDS EcHS_A1345 NC_009800.1 1340767 1341180 R identified by match to protein family HMM PF00816; global DNA-binding transcriptional dual regulator H-NS complement(1340767..1341180) Escherichia coli HS 5593396 YP_001458062.1 CDS EcHS_A1346 NC_009800.1 1341272 1341400 R identified by glimmer; hypothetical protein complement(1341272..1341400) Escherichia coli HS 5593397 YP_001458063.1 CDS tdk NC_009800.1 1341784 1342401 D catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 1341784..1342401 Escherichia coli HS 5593398 YP_001458064.1 CDS adhE NC_009800.1 1343702 1346377 R identified by similarity to SP:P0A9Q7; match to protein family HMM PF00171; match to protein family HMM PF00465; bifunctional acetaldehyde-CoA/alcohol dehydrogenase complement(1343702..1346377) Escherichia coli HS 5593534 YP_001458065.1 CDS EcHS_A1351 NC_009800.1 1346854 1347501 D identified by match to protein family HMM PF01914; match to protein family HMM TIGR00427; hypothetical protein 1346854..1347501 Escherichia coli HS 5593535 YP_001458066.1 CDS oppA NC_009800.1 1348239 1349870 D identified by match to protein family HMM PF00496; oligopeptide ABC transporter periplasmic oligopeptide-binding protein 1348239..1349870 Escherichia coli HS 5592598 YP_001458067.1 CDS oppB NC_009800.1 1349956 1350876 D identified by match to protein family HMM PF00528; oligopeptide transporter permease 1349956..1350876 Escherichia coli HS 5592599 YP_001458068.1 CDS oppC NC_009800.1 1350891 1351799 D identified by match to protein family HMM PF00528; oligopeptide ABC transporter permease OppC 1350891..1351799 Escherichia coli HS 5592600 YP_001458069.1 CDS oppD NC_009800.1 1351811 1352824 D identified by match to protein family HMM PF00005; match to protein family HMM PF08352; match to protein family HMM TIGR01727; oligopeptide transporter ATP-binding component 1351811..1352824 Escherichia coli HS 5593331 YP_001458070.1 CDS oppF NC_009800.1 1352821 1353825 D identified by match to protein family HMM PF00005; match to protein family HMM PF08352; match to protein family HMM TIGR01727; oligopeptide ABC transporter ATP-binding protein OppF 1352821..1353825 Escherichia coli HS 5593332 YP_001458071.1 CDS EcHS_A1357 NC_009800.1 1353878 1354207 R highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein; dsDNA-mimic protein complement(1353878..1354207) Escherichia coli HS 5593333 YP_001458072.1 CDS cls NC_009800.1 1354242 1355702 R catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol); cardiolipin synthetase complement(1354242..1355702) Escherichia coli HS 5593197 YP_001458073.1 CDS kch NC_009800.1 1356073 1357326 R identified by similarity to SP:P31069; match to protein family HMM PF02254; match to protein family HMM PF07885; voltage-gated potassium channel complement(1356073..1357326) Escherichia coli HS 5593198 YP_001458074.1 CDS EcHS_A1360 NC_009800.1 1357626 1357922 R unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity; hypothetical protein complement(1357626..1357922) Escherichia coli HS 5593199 YP_001458075.1 CDS tonB NC_009800.1 1358146 1358865 D membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins; transport protein TonB 1358146..1358865 Escherichia coli HS 5593249 YP_001458076.1 CDS yciA NC_009800.1 1358905 1359303 R YciA; hydrolase that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA; member of the the acyl coenzyme A hydrolase of proteins; acyl-CoA thioester hydrolase complement(1358905..1359303) Escherichia coli HS 5593250 YP_001458077.1 CDS ispZ NC_009800.1 1359408 1359947 R Involved in cell division; probably involved in intracellular septation; intracellular septation protein A complement(1359408..1359947) Escherichia coli HS 5593251 YP_001458078.1 CDS EcHS_A1364 NC_009800.1 1359977 1360720 R yciC; identified by match to protein family HMM PF06790; hypothetical protein complement(1359977..1360720) Escherichia coli HS 5593127 YP_001458079.1 CDS ompW NC_009800.1 1361077 1361715 D receptor for colicin S4; outer membrane protein W 1361077..1361715 Escherichia coli HS 5593128 YP_001458080.1 CDS EcHS_A1366 NC_009800.1 1361775 1362281 R yciE; identified by match to protein family HMM PF05974; hypothetical protein complement(1361775..1362281) Escherichia coli HS 5593129 YP_001458081.1 CDS yciF NC_009800.1 1362327 1362827 R identified by similarity to SP:P21362; match to protein family HMM PF05974; hypothetical protein complement(1362327..1362827) Escherichia coli HS 5593210 YP_001458082.1 CDS EcHS_A1368 NC_009800.1 1362885 1363079 R identified by similarity to GB:AAX64977.1; hypothetical protein complement(1362885..1363079) Escherichia coli HS 5593211 YP_001458083.1 CDS trpA NC_009800.1 1363473 1364279 R catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha complement(1363473..1364279) Escherichia coli HS 5593212 YP_001458084.1 CDS trpB NC_009800.1 1364279 1365472 R catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta complement(1364279..1365472) Escherichia coli HS 5592555 YP_001458085.1 CDS trpC NC_009800.1 1365484 1366845 R monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate; bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase complement(1365484..1366845) Escherichia coli HS 5592556 YP_001458086.1 CDS trpD NC_009800.1 1366846 1368441 R bifunctional anthranilate synthase II/anthranilate phosphoribosyltransferase; TrpD; forms a heterotetramer with Trp E and the complex catalyzes the formation of anthranilate from chorismate and glutamine; also catalyzes the formation of N-(5-phospho-D-ribosyl)-anthranilate from athranilate and 5-phospho-alpha-D-ribose 1-diphosphate; functions in tryptophan biosynthesis; bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase complement(1366846..1368441) Escherichia coli HS 5592557 YP_001458087.1 CDS trpE NC_009800.1 1368441 1370003 R with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I complement(1368441..1370003) Escherichia coli HS 5593150 YP_001458089.1 CDS EcHS_A1375 NC_009800.1 1370298 1371158 D trpH protein; identified by match to protein family HMM PF02811; phosphoesterase 1370298..1371158 Escherichia coli HS 5593152 YP_001458090.1 CDS EcHS_A1376 NC_009800.1 1371155 1371775 D identified by match to protein family HMM PF01300; match to protein family HMM TIGR00057; hypothetical protein 1371155..1371775 Escherichia coli HS 5592875 YP_001458091.1 CDS EcHS_A1377 NC_009800.1 1371803 1373698 D yciQ; hypothetical protein 1371803..1373698 Escherichia coli HS 5592876 YP_001458092.1 CDS rluB NC_009800.1 1373909 1374784 D catalyzes the synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA; 23S rRNA pseudouridylate synthase B 1373909..1374784 Escherichia coli HS 5592877 YP_001458093.1 CDS btuR NC_009800.1 1374824 1375414 R catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide; cob(I)yrinic acid a,c-diamide adenosyltransferase complement(1374824..1375414) Escherichia coli HS 5594980 YP_001458094.1 CDS EcHS_A1380 NC_009800.1 1375411 1376169 R identified by match to protein family HMM PF00106; match to protein family HMM PF08659; short chain dehydrogenase complement(1375411..1376169) Escherichia coli HS 5594981 YP_001458095.1 CDS sohB NC_009800.1 1376389 1377438 D SohB; periplasmic protein; member of the peptidase S49 family; periplasmic protease 1376389..1377438 Escherichia coli HS 5594982 YP_001458096.1 CDS EcHS_A1382 NC_009800.1 1377474 1377725 R identified by similarity to GB:CAD08416.1; hypothetical protein complement(1377474..1377725) Escherichia coli HS 5592927 YP_001458097.1 CDS topA NC_009800.1 1378105 1380702 D catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 1378105..1380702 Escherichia coli HS 5592928 YP_001458098.1 CDS cysB NC_009800.1 1380912 1381886 D LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation; transcriptional regulator CysB 1380912..1381886 Escherichia coli HS 5592929 YP_001458099.1 CDS EcHS_A1385 NC_009800.1 1382175 1382450 D identified by match to protein family HMM PF03811; IS1, transposase orfA 1382175..1382450 Escherichia coli HS 5592749 YP_001458100.1 CDS EcHS_A1386 NC_009800.1 1382369 1382872 D identified by match to protein family HMM PF03400; IS1, transposase orfB 1382369..1382872 Escherichia coli HS 5592750 YP_001458101.1 CDS acnA NC_009800.1 1383394 1386069 D Catalyzes the conversion of citrate to isocitrate; aconitate hydratase 1383394..1386069 Escherichia coli HS 5592751 YP_001458102.1 CDS ribA NC_009800.1 1386133 1386723 R catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate; GTP cyclohydrolase II complement(1386133..1386723) Escherichia coli HS 5592486 YP_001458103.1 CDS pgpB NC_009800.1 1386893 1387657 D identified by similarity to SP:P0A924; match to protein family HMM PF01569; phosphatidylglycerophosphatase B 1386893..1387657 Escherichia coli HS 5592487 YP_001458104.1 CDS EcHS_A1390 NC_009800.1 1387806 1388114 D yciS; identified by match to protein family HMM PF06305; hypothetical protein 1387806..1388114 Escherichia coli HS 5592488 YP_001458105.1 CDS EcHS_A1391 NC_009800.1 1388121 1389290 D identified by match to protein family HMM PF07719; tetratricopeptide repeat protein 1388121..1389290 Escherichia coli HS 5592448 YP_001458106.1 CDS EcHS_A1392 NC_009800.1 1389324 1389470 R identified by glimmer; hypothetical protein complement(1389324..1389470) Escherichia coli HS 5592449 YP_001458107.1 CDS pyrF NC_009800.1 1389483 1390220 D type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 1389483..1390220 Escherichia coli HS 5592450 YP_001458108.1 CDS EcHS_A1394 NC_009800.1 1390220 1390546 D involved in start site selection during the initiation of translation; translation initiation factor Sui1 1390220..1390546 Escherichia coli HS 5592726 YP_001458109.1 CDS EcHS_A1395 NC_009800.1 1390672 1390890 R identified by similarity to SP:P0ADA7; lipoprotein complement(1390672..1390890) Escherichia coli HS 5592727 YP_001458110.1 CDS EcHS_A1396 NC_009800.1 1391159 1391908 R identified by match to protein family HMM PF00455; match to protein family HMM PF08220; match to protein family HMM PF08279; DeoR family transcriptional regulator complement(1391159..1391908) Escherichia coli HS 5592728 YP_001458111.1 CDS EcHS_A1397 NC_009800.1 1391998 1392180 R hypothetical protein complement(1391998..1392180) Escherichia coli HS 5592801 YP_001458112.1 CDS EcHS_A1398 NC_009800.1 1392318 1394303 R c-di-GMP phosphodiesterase; probably degrades signalling molecule c-di-GMP; RNase II stability modulator complement(1392318..1394303) Escherichia coli HS 5592802 YP_001458113.1 CDS rnb NC_009800.1 1394538 1396472 R Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction; exoribonuclease II complement(1394538..1396472) Escherichia coli HS 5592803 YP_001458114.1 CDS EcHS_A1400 NC_009800.1 1396540 1397745 R hypothetical protein complement(1396540..1397745) Escherichia coli HS 5592703 YP_001458115.1 CDS fabI NC_009800.1 1397811 1398599 R Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-ACP reductase complement(1397811..1398599) Escherichia coli HS 5592704 YP_001458116.1 CDS EcHS_A1402 NC_009800.1 1398614 1398712 D identified by glimmer; hypothetical protein 1398614..1398712 Escherichia coli HS 5592705 YP_001458117.1 CDS EcHS_A1403 NC_009800.1 1398768 1399214 R ycjD; identified by similarity to GB:ABB66373.1; match to protein family HMM PF04480; hypothetical protein complement(1398768..1399214) Escherichia coli HS 5592564 YP_001458118.1 CDS sapF NC_009800.1 1399282 1400088 R identified by similarity to SP:P36638; match to protein family HMM PF00005; peptide ABC transporter ATP-binding protein SapF complement(1399282..1400088) Escherichia coli HS 5592565 YP_001458119.1 CDS sapD NC_009800.1 1400090 1401082 R identified by match to protein family HMM PF00005; match to protein family HMM PF08352; match to protein family HMM TIGR01727; peptide ABC transporter ATP-binding protein SapD complement(1400090..1401082) Escherichia coli HS 5592566 YP_001458120.1 CDS sapC NC_009800.1 1401082 1401972 R identified by match to protein family HMM PF00528; peptide ABC transporter permease SapC complement(1401082..1401972) Escherichia coli HS 5592603 YP_001458121.1 CDS sapB NC_009800.1 1401959 1402924 R identified by match to protein family HMM PF00528; peptide ABC transporter permease SapB complement(1401959..1402924) Escherichia coli HS 5592604 YP_001458122.1 CDS sapA NC_009800.1 1402921 1404564 R identified by match to protein family HMM PF00496; peptide ABC transporter periplasmic peptide-binding protein complement(1402921..1404564) Escherichia coli HS 5592605 YP_001458123.1 CDS EcHS_A1409 NC_009800.1 1404876 1405121 R ymjA; hypothetical protein complement(1404876..1405121) Escherichia coli HS 5592098 YP_001458124.1 CDS EcHS_A1410 NC_009800.1 1405137 1405247 R identified by glimmer; hypothetical protein complement(1405137..1405247) Escherichia coli HS 5592099 YP_001458125.1 CDS EcHS_A1411 NC_009800.1 1405255 1406640 R identified by match to protein family HMM PF00324; amino acid permease complement(1405255..1406640) Escherichia coli HS 5592100 YP_001458126.1 CDS puuA NC_009800.1 1406943 1408361 R identified by similarity to SP:P78061; match to protein family HMM PF00120; glutamate--putrescine ligase complement(1406943..1408361) Escherichia coli HS 5592343 YP_001458127.1 CDS puuD NC_009800.1 1408573 1409337 D catalyzes the degradation of gamma-glutamyl-gamma-aminobutyrate into glutamate and gamma-aminobutyrate; gamma-glutamyl-gamma-aminobutyrate hydrolase 1408573..1409337 Escherichia coli HS 5592344 YP_001458128.1 CDS puuR NC_009800.1 1409364 1409921 D regulates genes involved in putrescine degradation; DNA-binding transcriptional repressor PuuR 1409364..1409921 Escherichia coli HS 5592345 YP_001458129.1 CDS puuC NC_009800.1 1410196 1411683 D catalyzes the formation of gamma-glutamyl-gamma-aminobutyrate from Gamma-glutamyl-gamma-aminobutyraldehyde; involved in putrescine degradation; gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase 1410196..1411683 Escherichia coli HS 5592394 YP_001458130.1 CDS puuB NC_009800.1 1411685 1412965 D identified by similarity to SP:P37906; match to protein family HMM PF01266; gamma-glutamylputrescine oxidoreductase 1411685..1412965 Escherichia coli HS 5592395 YP_001458131.1 CDS gabT1 NC_009800.1 1413003 1414268 D putrescine-inducible GABA aminotransferase; catalyzes the formation of glutamate and succinate semialdehyde from 4-aminobutyrate and 2-oxoglutarate; 4-aminobutyrate aminotransferase 1413003..1414268 Escherichia coli HS 5592396 YP_001458132.1 CDS pspF NC_009800.1 1414386 1415363 R transcriptional activator for pspABCE which are induced in response to phage proteins, membrane altering stresses, and impaired proton expor; phage shock protein operon transcriptional activator complement(1414386..1415363) Escherichia coli HS 5591415 YP_001458133.1 CDS pspA NC_009800.1 1415530 1416198 D involved in maintaining membrane potential under membrane stress conditions; also acts as a negative transcriptional regulator of the phage shock protein (psp) operon(pspABCDE) by regulating the transcriptional activator PspF; phage shock protein PspA 1415530..1416198 Escherichia coli HS 5591416 YP_001458134.1 CDS pspB NC_009800.1 1416252 1416476 D acts together with PspC to induce psp operon during infection with phage, exposure to ethanol or osmotic shock; forms a complex with PspA and C; PspC is required for PspAB binding; phage shock protein B 1416252..1416476 Escherichia coli HS 5591417 YP_001458135.1 CDS pspC NC_009800.1 1416476 1416835 D with PsbB forms toxin/antitoxin pair; activates the psp operon in response to phage infection, exposure to ethanol or osmotic shock; DNA-binding transcriptional activator PspC 1416476..1416835 Escherichia coli HS 5592319 YP_001458136.1 CDS pspD NC_009800.1 1416844 1417065 D identified by match to protein family HMM TIGR02979; peripheral inner membrane phage-shock protein 1416844..1417065 Escherichia coli HS 5592320 YP_001458137.1 CDS pspE NC_009800.1 1417140 1417454 D rhodanese; catalyzes the formation of thiocyanate from thiosulfate and hydrogen cyanide; thiosulfate:cyanide sulfurtransferase 1417140..1417454 Escherichia coli HS 5592321 YP_001458138.1 CDS EcHS_A1424 NC_009800.1 1417666 1419345 D identified by match to protein family HMM PF00128; alpha amylase 1417666..1419345 Escherichia coli HS 5592337 YP_001458139.1 CDS EcHS_A1425 NC_009800.1 1419359 1420651 D identified by match to protein family HMM PF01547; sugar ABC transporter periplasmic sugar-binding protein 1419359..1420651 Escherichia coli HS 5592338 YP_001458140.1 CDS EcHS_A1426 NC_009800.1 1420672 1421553 D identified by match to protein family HMM PF00528; sugar ABC transporter permease 1420672..1421553 Escherichia coli HS 5592339 YP_001458141.1 CDS EcHS_A1427 NC_009800.1 1421540 1422382 D identified by match to protein family HMM PF00528; sugar ABC transporter permease 1421540..1422382 Escherichia coli HS 5592083 YP_001458142.1 CDS EcHS_A1428 NC_009800.1 1422413 1423465 D identified by match to protein family HMM PF00107; zinc-binding dehydrogenase oxidoreductase 1422413..1423465 Escherichia coli HS 5592084 YP_001458143.1 CDS EcHS_A1429 NC_009800.1 1423484 1424272 D ycjR; identified by match to protein family HMM PF01261; AP endonuclease 1423484..1424272 Escherichia coli HS 5592085 YP_001458144.1 CDS EcHS_A1430 NC_009800.1 1424282 1425337 D identified by match to protein family HMM PF01408; match to protein family HMM PF02894; gfo/idh/mocA family protein 1424282..1425337 Escherichia coli HS 5591894 YP_001458145.1 CDS EcHS_A1431 NC_009800.1 1425334 1427601 D ycjT; identified by match to protein family HMM PF03632; match to protein family HMM PF03633; match to protein family HMM PF03636; glycosyl hydrolase 1425334..1427601 Escherichia coli HS 5591895 YP_001458146.1 CDS pgmB NC_009800.1 1427598 1428257 D identified by match to protein family HMM PF00702; match to protein family HMM TIGR01509; match to protein family HMM TIGR01990; match to protein family HMM TIGR02009; beta-phosphoglucomutase 1427598..1428257 Escherichia coli HS 5591896 YP_001458147.1 CDS EcHS_A1433 NC_009800.1 1428271 1429353 D identified by match to protein family HMM PF00005; match to protein family HMM PF03459; match to protein family HMM PF08402; sugar ABC transporter ATP-binding protein 1428271..1429353 Escherichia coli HS 5590935 YP_001458148.1 CDS ompG NC_009800.1 1429398 1430303 D identified by match to protein family HMM TIGR03304; outer membrane protein G 1429398..1430303 Escherichia coli HS 5590936 YP_001458149.1 CDS EcHS_A1435 NC_009800.1 1430414 1431412 R identified by match to protein family HMM PF00356; match to protein family HMM PF00532; LacI family transcription regulator complement(1430414..1431412) Escherichia coli HS 5590937 YP_001458150.1 CDS EcHS_A1436 NC_009800.1 1431568 1432965 D identified by match to protein family HMM PF04317; hypothetical protein 1431568..1432965 Escherichia coli HS 5591068 YP_001458151.1 CDS EcHS_A1437 NC_009800.1 1432962 1434023 D ycjF; identified by match to protein family HMM PF05128; match to protein family HMM TIGR01620; hypothetical protein 1432962..1434023 Escherichia coli HS 5591069 YP_001458152.1 CDS tyrR NC_009800.1 1434171 1435712 D regulates genes involved in the biosynthesis and transport of aromatic amino acids; DNA-binding transcriptional regulator TyrR 1434171..1435712 Escherichia coli HS 5591070 YP_001458153.1 CDS tpx NC_009800.1 1435756 1436262 R antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase complement(1435756..1436262) Escherichia coli HS 5591911 YP_001458154.1 CDS EcHS_A1440 NC_009800.1 1436381 1437346 D identified by match to protein family HMM PF01188; match to protein family HMM PF02746; mandelate racemase/muconate lactonizing enzyme family protein 1436381..1437346 Escherichia coli HS 5591912 YP_001458155.1 CDS EcHS_A1442 NC_009800.1 1437321 1438109 R identified by match to protein family HMM PF00246; murein peptide amidase A complement(1437321..1438109) Escherichia coli HS 5591913 YP_001458156.1 CDS EcHS_A1443 NC_009800.1 1438384 1439304 R ycjY; hypothetical protein complement(1438384..1439304) Escherichia coli HS 5590952 YP_001458157.1 CDS EcHS_A1444 NC_009800.1 1439442 1440341 D identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator 1439442..1440341 Escherichia coli HS 5590953 YP_001458158.1 CDS EcHS_A1445 NC_009800.1 1440541 1440651 R identified by glimmer; hypothetical protein complement(1440541..1440651) Escherichia coli HS 5590954 YP_001458159.1 CDS mppA NC_009800.1 1440678 1442291 D identified by match to protein family HMM PF00496; periplasmic murein peptide-binding protein 1440678..1442291 Escherichia coli HS 5595137 YP_001458160.1 CDS EcHS_A1447 NC_009800.1 1442342 1443373 R identified by match to protein family HMM PF00924; small conductance mechanosensitive ion channel family protein complement(1442342..1443373) Escherichia coli HS 5595138 YP_001458161.1 CDS EcHS_A1448 NC_009800.1 1443617 1443874 D ynaJ; hypothetical protein 1443617..1443874 Escherichia coli HS 5595139 YP_001458162.1 CDS uspE NC_009800.1 1443924 1444874 R with UspC and UspD is involved in resistance to UV irradiation; universal stress protein UspE complement(1443924..1444874) Escherichia coli HS 5592131 YP_001458163.1 CDS fnr NC_009800.1 1445026 1445778 R Global transcription factor that controls the expression of over 100 target genes in response to anoxia; fumarate/nitrate reduction transcriptional regulator complement(1445026..1445778) Escherichia coli HS 5592132 YP_001458164.1 CDS ogt NC_009800.1 1445973 1446488 R identified by similarity to SP:P0AFH0; match to protein family HMM PF01035; match to protein family HMM PF02870; match to protein family HMM TIGR00589; O-6-alkylguanine-DNA:cysteine-protein methyltransferase complement(1445973..1446488) Escherichia coli HS 5592133 YP_001458165.1 CDS abgT NC_009800.1 1446499 1448025 R identified by similarity to SP:P46133; match to protein family HMM PF03806; match to protein family HMM TIGR00819; aminobenzoyl-glutamate transporter complement(1446499..1448025) Escherichia coli HS 5591776 YP_001458166.1 CDS abgB NC_009800.1 1448062 1449507 R identified by similarity to SP:P76052; match to protein family HMM PF01546; match to protein family HMM TIGR01891; aminobenzoyl-glutamate utilization protein B complement(1448062..1449507) Escherichia coli HS 5591777 YP_001458167.1 CDS abgA NC_009800.1 1449507 1450817 R identified by similarity to SP:P77357; match to protein family HMM PF01546; match to protein family HMM PF07687; match to protein family HMM TIGR01891; aminobenzoyl-glutamate utilization protein A complement(1449507..1450817) Escherichia coli HS 5591778 YP_001458168.1 CDS EcHS_A1456 NC_009800.1 1450893 1450994 R identified by glimmer; hypothetical protein complement(1450893..1450994) Escherichia coli HS 5591662 YP_001458169.1 CDS EcHS_A1455 NC_009800.1 1450993 1451901 D identified by similarity to SP:P77744; match to protein family HMM PF00126; match to protein family HMM PF03466; DNA-binding transcriptional regulator 1450993..1451901 Escherichia coli HS 5591663 YP_001458170.1 CDS EcHS_A1457 NC_009800.1 1452231 1452794 D identified by match to protein family HMM PF01713; Smr domain-containing protein 1452231..1452794 Escherichia coli HS 5591665 YP_001458171.1 CDS EcHS_A1458 NC_009800.1 1452815 1454107 R identified by match to protein family HMM PF00990; match to protein family HMM PF08448; match to protein family HMM TIGR00229; match to protein family HMM TIGR00254; sensory box-containing diguanylate cyclase complement(1452815..1454107) Escherichia coli HS 5591666 YP_001458172.1 CDS zntB NC_009800.1 1454302 1455285 D ydaN; identified by match to protein family HMM PF01544; zinc transporter 1454302..1455285 Escherichia coli HS 5591758 YP_001458173.1 CDS dbpA NC_009800.1 1455763 1457136 D exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA; ATP-dependent RNA helicase DbpA 1455763..1457136 Escherichia coli HS 5591760 YP_001458174.1 CDS EcHS_A1461 NC_009800.1 1457265 1458200 R TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs; C32 tRNA thiolase complement(1457265..1458200) Escherichia coli HS 5591795 YP_001458175.1 CDS uspF NC_009800.1 1458377 1458811 R identified by similarity to SP:P37903; match to protein family HMM PF00582; universal stress protein F complement(1458377..1458811) Escherichia coli HS 5591796 YP_001458176.1 CDS ompN NC_009800.1 1458952 1460085 R identified by similarity to SP:P77747; match to protein family HMM PF00267; outer membrane protein N complement(1458952..1460085) Escherichia coli HS 5591697 YP_001458177.1 CDS ydbK NC_009800.1 1460452 1463976 R identified by match to protein family HMM PF00037; match to protein family HMM PF01558; match to protein family HMM PF01855; match to protein family HMM TIGR02176; pyruvate-flavodoxin oxidoreductase complement(1460452..1463976) Escherichia coli HS 5591699 YP_001458178.1 CDS EcHS_A1465 NC_009800.1 1464250 1464516 D lipoprotein 1464250..1464516 Escherichia coli HS 5591447 YP_001458179.1 CDS hslJ NC_009800.1 1464513 1464935 R identified by similarity to SP:P52644; match to protein family HMM PF03724; heat-inducible protein complement(1464513..1464935) Escherichia coli HS 5591448 YP_001458180.1 CDS idhA NC_009800.1 1465046 1466035 R identified by similarity to SP:P52643; match to protein family HMM PF00389; match to protein family HMM PF02826; D-lactate dehydrogenase complement(1465046..1466035) Escherichia coli HS 5591397 YP_001458181.1 CDS EcHS_A1468 NC_009800.1 1466243 1468882 D ydbH; identified by similarity to SP:P52645; hypothetical protein 1466243..1468882 Escherichia coli HS 5591398 YP_001458182.1 CDS EcHS_A1469 NC_009800.1 1468879 1469064 D ynbE; lipoprotein 1468879..1469064 Escherichia coli HS 5591399 YP_001458183.1 CDS EcHS_A1470 NC_009800.1 1469072 1469398 D ydbL; identified by similarity to GB:AAN80294.1; match to protein family HMM PF07027; hypothetical protein 1469072..1469398 Escherichia coli HS 5591653 YP_001458184.1 CDS feaR NC_009800.1 1469570 1470475 R activator of genes involved in phenylacetic acid catabolism; DNA-binding transcriptional activator FeaR complement(1469570..1470475) Escherichia coli HS 5591654 YP_001458185.1 CDS feaB NC_009800.1 1470711 1472210 D identified by similarity to SP:P80668; match to protein family HMM PF00171; phenylacetaldehyde dehydrogenase 1470711..1472210 Escherichia coli HS 5591655 YP_001458186.1 CDS tynA NC_009800.1 1472269 1474542 R catalyzes the formation of phenylacetaldehyde from 2-phenylethylamine; tyramine oxidase complement(1472269..1474542) Escherichia coli HS 5591621 YP_001458187.1 CDS paaN NC_009800.1 1474790 1476835 R catalyzes the ring cleavage reaction in phenylacetate degradation and the formation of 3-hydroxyacyl-CoA from crotonyl-CoA; bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase complement(1474790..1476835) Escherichia coli HS 5591622 YP_001458188.1 CDS paaA NC_009800.1 1477120 1478049 D with PaaBCDE catalyzes the hydroxylation of phenylacetyl-CoA; phenylacetate-CoA oxygenase subunit PaaA 1477120..1478049 Escherichia coli HS 5591623 YP_001458189.1 CDS paaB NC_009800.1 1478061 1478348 D with PaaBCDE catalyzes the hydroxylation of phenylacetyl-CoA; involved in phenylacetate degradation; phenylacetate-CoA oxygenase subunit PaaB 1478061..1478348 Escherichia coli HS 5591449 YP_001458190.1 CDS paaI NC_009800.1 1478357 1479103 D identified by match to protein family HMM PF05138; match to protein family HMM TIGR02158; phenylacetate-CoA oxygenase, PaaI subunit 1478357..1479103 Escherichia coli HS 5591450 YP_001458191.1 CDS paaJ NC_009800.1 1479118 1479615 D identified by match to protein family HMM PF01883; match to protein family HMM TIGR02159; phenylacetate-CoA oxygenase, PaaJ subunit 1479118..1479615 Escherichia coli HS 5591451 YP_001458192.1 CDS paaK NC_009800.1 1479623 1480693 D identified by match to protein family HMM PF00111; match to protein family HMM PF00175; match to protein family HMM PF00970; match to protein family HMM TIGR02160; phenylacetate-CoA oxygenase/reductase, PaaK subunit 1479623..1480693 Escherichia coli HS 5591587 YP_001458193.1 CDS EcHS_A1480 NC_009800.1 1480690 1481457 D identified by match to protein family HMM PF00378; enoyl-CoA hydratase 1480690..1481457 Escherichia coli HS 5591588 YP_001458194.1 CDS paaB NC_009800.1 1481457 1482245 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 1481457..1482245 Escherichia coli HS 5591589 YP_001458195.1 CDS paaC NC_009800.1 1482247 1483674 D converts 3-hydroxyadipyl-CoA to beta-ketoadipyl-CoA in phenylacetate degradation; 3-hydroxyacyl-CoA dehydrogenase 1482247..1483674 Escherichia coli HS 5591517 YP_001458196.1 CDS paaD NC_009800.1 1483664 1484086 D identified by similarity to SP:P76084; match to protein family HMM PF03061; match to protein family HMM TIGR00369; match to protein family HMM TIGR02286; phenylacetic acid degradation protein PaaD 1483664..1484086 Escherichia coli HS 5591518 YP_001458197.1 CDS pcaF NC_009800.1 1484086 1485291 D catalyzes the thiolytic cleavage of beta-ketoadipyl-CoA to succinate and acetyl-CoA; beta-ketoadipyl CoA thiolase 1484086..1485291 Escherichia coli HS 5591519 YP_001458198.1 CDS paaF NC_009800.1 1485318 1486631 D identified by match to protein family HMM TIGR02155; phenylacetate-CoA ligase 1485318..1486631 Escherichia coli HS 5591575 YP_001458199.1 CDS paaX NC_009800.1 1486732 1487682 D identified by similarity to SP:P76086; match to protein family HMM PF07848; match to protein family HMM PF08223; match to protein family HMM TIGR02277; phenylacetic acid degradation operon negative regulatory protein PaaX 1486732..1487682 Escherichia coli HS 5591576 YP_001458200.1 CDS paaY NC_009800.1 1487664 1488254 D identified by match to protein family HMM PF00132; match to protein family HMM TIGR02287; phenylacetic acid degradation protein PaaY 1487664..1488254 Escherichia coli HS 5591577 YP_001458201.1 CDS EcHS_A1488 NC_009800.1 1488585 1494440 D identified by match to protein family HMM PF03797; autotransporter (AT) family porin 1488585..1494440 Escherichia coli HS 5591261 YP_001458202.1 CDS EcHS_A1489 NC_009800.1 1494648 1495508 D identified by match to protein family HMM PF00248; oxidoreductase 1494648..1495508 Escherichia coli HS 5591262 YP_001458203.1 CDS EcHS_A1490 NC_009800.1 1495572 1497878 D ydbD; identified by similarity to SP:P25907; hypothetical protein 1495572..1497878 Escherichia coli HS 5591263 YP_001458204.1 CDS EcHS_A1491 NC_009800.1 1498049 1498654 D ynbA; identified by match to protein family HMM PF01066; CDP-alcohol phosphatidyltransferase 1498049..1498654 Escherichia coli HS 5591279 YP_001458205.1 CDS cdsA2 NC_009800.1 1498654 1499550 D identified by match to protein family HMM PF01148; phosphatidate cytidylyltransferase 1498654..1499550 Escherichia coli HS 5591280 YP_001458206.1 CDS EcHS_A1493 NC_009800.1 1499566 1501323 D ynbC; identified by similarity to SP:P76092; hypothetical protein 1499566..1501323 Escherichia coli HS 5591281 YP_001458207.1 CDS EcHS_A1494 NC_009800.1 1501337 1502629 D identified by match to protein family HMM PF00782; match to protein family HMM PF01569; PAP2 family protein 1501337..1502629 Escherichia coli HS 5592328 YP_001458208.1 CDS azoR NC_009800.1 1502683 1503288 R FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds; azoreductase complement(1502683..1503288) Escherichia coli HS 5592329 YP_001458209.1 CDS hrpA NC_009800.1 1503489 1507391 D involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain; ATP-dependent RNA helicase HrpA 1503489..1507391 Escherichia coli HS 5592330 YP_001458210.1 CDS EcHS_A1497 NC_009800.1 1507663 1508463 D ydcF; identified by match to protein family HMM PF02698; hypothetical protein 1507663..1508463 Escherichia coli HS 5594721 YP_001458211.1 CDS aldA NC_009800.1 1508660 1510099 D NAD-linked; aldehyde dehydrogenase 1508660..1510099 Escherichia coli HS 5594722 YP_001458212.1 CDS gapC NC_009800.1 1510141 1511142 R identified by similarity to SP:P33898; match to protein family HMM PF00044; match to protein family HMM PF02800; match to protein family HMM TIGR01534; glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) complement(1510141..1511142) Escherichia coli HS 5594723 YP_001458213.1 CDS EcHS_A1500 NC_009800.1 1511295 1511861 D B-type di-heme cytochrome with a major alpha-absorption peak at 561 nm and a minor peak at 555 nm; cytochrome b561 1511295..1511861 Escherichia coli HS 5592322 YP_001458214.1 CDS EcHS_A1501 NC_009800.1 1512106 1512279 D ydcA; hypothetical protein 1512106..1512279 Escherichia coli HS 5592323 YP_001458215.1 CDS EcHS_A1502 NC_009800.1 1512391 1512558 R identified by glimmer; hypothetical protein complement(1512391..1512558) Escherichia coli HS 5592324 YP_001458216.1 CDS trg NC_009800.1 1512899 1514539 D identified by similarity to SP:P05704; match to protein family HMM PF00015; match to protein family HMM PF00672; match to protein family HMM PF02203; methyl-accepting chemotaxis protein III 1512899..1514539 Escherichia coli HS 5595393 YP_001458217.1 CDS EcHS_A1504 NC_009800.1 1514577 1515500 R identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator complement(1514577..1515500) Escherichia coli HS 5595394 YP_001458218.1 CDS EcHS_A1505 NC_009800.1 1515717 1517060 D ydcJ; identified by similarity to SP:P15747; match to protein family HMM PF07063; hypothetical protein 1515717..1517060 Escherichia coli HS 5595395 YP_001458219.1 CDS mdoD NC_009800.1 1517285 1518940 D involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans; glucan biosynthesis protein D 1517285..1518940 Escherichia coli HS 5595300 YP_001458220.1 CDS EcHS_A1507 NC_009800.1 1519080 1519304 D ydcH; identified by similarity to GB:CAE37095.1; match to protein family HMM PF04325; hypothetical protein 1519080..1519304 Escherichia coli HS 5595301 YP_001458221.1 CDS rimL NC_009800.1 1519367 1519903 D identified by similarity to SP:P13857; match to protein family HMM PF00583; ribosomal-protein-L7/L12-serine acetyltransferase 1519367..1519903 Escherichia coli HS 5595302 YP_001458222.1 CDS EcHS_A1509 NC_009800.1 1519898 1520878 R ydcK; identified by similarity to SP:P15644; hypothetical protein complement(1519898..1520878) Escherichia coli HS 5592558 YP_001458223.1 CDS tehA NC_009800.1 1521002 1521994 D identified by similarity to SP:P25396; match to protein family HMM PF03595; match to protein family HMM TIGR00816; potassium-tellurite ethidium and proflavin transporter 1521002..1521994 Escherichia coli HS 5592559 YP_001458224.1 CDS tehB NC_009800.1 1521991 1522584 D with TehA confers resistance to tellurite; tellurite resistance protein TehB 1521991..1522584 Escherichia coli HS 5592560 YP_001458225.1 CDS EcHS_A1512 NC_009800.1 1522736 1522855 D identified by glimmer; hypothetical protein 1522736..1522855 Escherichia coli HS 5594787 YP_001458226.1 CDS EcHS_A1513 NC_009800.1 1522887 1523555 D ydcL; lipoprotein 1522887..1523555 Escherichia coli HS 5594788 YP_001458227.1 CDS EcHS_A1516 NC_009800.1 1524087 1525295 D identified by match to protein family HMM PF01385; match to protein family HMM PF07282; match to protein family HMM TIGR01766; IS605 family transposase OrfB 1524087..1525295 Escherichia coli HS 5594564 YP_001458228.1 CDS EcHS_A1518 NC_009800.1 1525335 1526603 R identified by match to protein family HMM PF00860; match to protein family HMM PF03594; match to protein family HMM TIGR00843; benzoate transporter complement(1525335..1526603) Escherichia coli HS 5594565 YP_001458229.1 CDS EcHS_A1517 NC_009800.1 1526602 1527138 D identified by match to protein family HMM PF01381; match to protein family HMM PF07883; DNA-binding protein 1526602..1527138 Escherichia coli HS 5594566 YP_001458230.1 CDS EcHS_A1519 NC_009800.1 1527169 1529172 D identified by match to protein family HMM PF01136; U32 family peptidase 1527169..1529172 Escherichia coli HS 5591352 YP_001458231.1 CDS EcHS_A1520 NC_009800.1 1529264 1529494 R yncJ; hypothetical protein complement(1529264..1529494) Escherichia coli HS 5591353 YP_001458232.1 CDS EcHS_A1521 NC_009800.1 1529551 1529673 R identified by glimmer; hypothetical protein complement(1529551..1529673) Escherichia coli HS 5591354 YP_001458233.1 CDS EcHS_A1522 NC_009800.1 1529917 1530354 D ydcQ; identified by match to protein family HMM PF01381; match to protein family HMM PF03681; hypothetical protein 1529917..1530354 Escherichia coli HS 5594938 YP_001458234.1 CDS EcHS_A1523 NC_009800.1 1530433 1531839 D identified by match to protein family HMM PF00155; match to protein family HMM PF00392; GntR family transcriptional regulator 1530433..1531839 Escherichia coli HS 5594939 YP_001458235.1 CDS ydcS NC_009800.1 1532084 1533229 D identified by match to protein family HMM PF01547; ABC transporter periplasmic substrate-binding protein 1532084..1533229 Escherichia coli HS 5594940 YP_001458236.1 CDS ydcT NC_009800.1 1533247 1534260 D identified by match to protein family HMM PF00005; match to protein family HMM PF08402; ABC transporter ATP-binding protein 1533247..1534260 Escherichia coli HS 5594508 YP_001458237.1 CDS ydcU NC_009800.1 1534261 1535202 D identified by match to protein family HMM PF00528; ABC transporter permease 1534261..1535202 Escherichia coli HS 5594509 YP_001458238.1 CDS ydcV NC_009800.1 1535192 1535986 D identified by match to protein family HMM PF00528; ABC transporter permease 1535192..1535986 Escherichia coli HS 5594510 YP_001458239.1 CDS ydcW NC_009800.1 1536008 1537432 D catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation; gamma-aminobutyraldehyde dehydrogenase 1536008..1537432 Escherichia coli HS 5593192 YP_001458240.1 CDS EcHS_A1529 NC_009800.1 1537496 1537771 D identified by match to protein family HMM PF03811; IS1, transposase orfA 1537496..1537771 Escherichia coli HS 5593193 YP_001458241.1 CDS EcHS_A1530 NC_009800.1 1537690 1538193 D identified by match to protein family HMM PF03400; IS1, transposase orfB 1537690..1538193 Escherichia coli HS 5593194 YP_001458242.1 CDS EcHS_A1531 NC_009800.1 1538284 1538532 D NULL; hypothetical protein 1538284..1538532 Escherichia coli HS 5592405 YP_001458243.1 CDS EcHS_A1532 NC_009800.1 1538618 1538851 D hypothetical protein 1538618..1538851 Escherichia coli HS 5592406 YP_001458244.1 CDS EcHS_A1533 NC_009800.1 1538852 1539301 R identified by match to protein family HMM PF04657; hypothetical protein complement(1538852..1539301) Escherichia coli HS 5592407 YP_001458245.1 CDS EcHS_A1534 NC_009800.1 1539298 1539879 R identified by match to protein family HMM PF00583; acetyltransferase complement(1539298..1539879) Escherichia coli HS 5592298 YP_001458246.1 CDS EcHS_A1535 NC_009800.1 1539997 1541034 D identified by match to protein family HMM PF00107; zinc-binding dehydrogenase oxidoreductase 1539997..1541034 Escherichia coli HS 5592299 YP_001458247.1 CDS EcHS_A1536 NC_009800.1 1541232 1541897 D identified by match to protein family HMM PF00392; match to protein family HMM PF07729; DNA-binding transcriptional regulator 1541232..1541897 Escherichia coli HS 5592300 YP_001458248.1 CDS EcHS_A1538 NC_009800.1 1541933 1544035 R identified by match to protein family HMM PF00593; match to protein family HMM PF07715; match to protein family HMM TIGR03304; TonB-dependent receptor complement(1541933..1544035) Escherichia coli HS 5592266 YP_001458249.1 CDS EcHS_A1537 NC_009800.1 1544034 1544129 D identified by glimmer; hypothetical protein 1544034..1544129 Escherichia coli HS 5592267 YP_001458250.1 CDS EcHS_A1539 NC_009800.1 1544277 1545338 D hypothetical protein 1544277..1545338 Escherichia coli HS 5592268 YP_001458251.1 CDS ansP NC_009800.1 1545453 1546952 R identified by match to protein family HMM PF00324; L-asparagine permease complement(1545453..1546952) Escherichia coli HS 5592910 YP_001458252.1 CDS EcHS_A1541 NC_009800.1 1547218 1547835 D transferase-like protein 1547218..1547835 Escherichia coli HS 5592911 YP_001458253.1 CDS EcHS_A1543 NC_009800.1 1548708 1548800 D identified by glimmer; hypothetical protein 1548708..1548800 Escherichia coli HS 5591276 YP_001458254.1 CDS EcHS_A1544 NC_009800.1 1549039 1549830 D identified by match to protein family HMM PF01609; ISEc1, transposase 1549039..1549830 Escherichia coli HS 5591277 YP_001458255.1 CDS EcHS_A1545 NC_009800.1 1549863 1550090 D 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown; 4-oxalocrotonate tautomerase 1549863..1550090 Escherichia coli HS 5591278 YP_001458256.1 CDS EcHS_A1546 NC_009800.1 1550094 1550663 R identified by similarity to SP:P76121; flavin reductase domain-containing protein complement(1550094..1550663) Escherichia coli HS 5591548 YP_001458257.1 CDS EcHS_A1547 NC_009800.1 1550836 1551681 D identified by match to protein family HMM PF00797; N-hydroxyarylamine O-acetyltransferase 1550836..1551681 Escherichia coli HS 5591549 YP_001458258.1 CDS EcHS_A1548 NC_009800.1 1551777 1552670 R yddE; identified by match to protein family HMM PF02567; match to protein family HMM TIGR00654; hypothetical protein complement(1551777..1552670) Escherichia coli HS 5591550 YP_001458259.1 CDS narI1 NC_009800.1 1552749 1553429 R identified by similarity to SP:P11350; match to protein family HMM PF02665; match to protein family HMM TIGR00351; respiratory nitrate reductase, gamma subunit complement(1552749..1553429) Escherichia coli HS 5591493 YP_001458260.1 CDS narW NC_009800.1 1553426 1554121 R identified by similarity to SP:P19317; match to protein family HMM PF02613; match to protein family HMM TIGR00684; respiratory nitrate reductase 2 delta chain complement(1553426..1554121) Escherichia coli HS 5591494 YP_001458261.1 CDS narY NC_009800.1 1554121 1555665 R identified by similarity to SP:P19318; match to protein family HMM TIGR01660; nitrate reductase, beta subunit complement(1554121..1555665) Escherichia coli HS 5591495 YP_001458262.1 CDS narZ NC_009800.1 1555662 1559402 R identified by match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM TIGR01580; nitrate reductase, alpha subunit complement(1555662..1559402) Escherichia coli HS 5591688 YP_001458263.1 CDS narU NC_009800.1 1559484 1560872 R identified by similarity to SP:P37758; match to protein family HMM PF07690; match to protein family HMM TIGR00886; nitrite extrusion protein 2 complement(1559484..1560872) Escherichia coli HS 5591689 YP_001458264.1 CDS EcHS_A1554 NC_009800.1 1561196 1562527 R identified by similarity to SP:P76123; leucine-rich repeat-containing protein complement(1561196..1562527) Escherichia coli HS 5591690 YP_001458265.1 CDS EcHS_A1555 NC_009800.1 1562551 1562841 R outer membrane porin, truncation complement(1562551..1562841) Escherichia coli HS 5594996 YP_001458266.1 CDS EcHS_A1556 NC_009800.1 1563100 1563981 R yddG; identified by match to protein family HMM PF00892; hypothetical protein complement(1563100..1563981) Escherichia coli HS 5594997 YP_001458267.1 CDS fdnG NC_009800.1 1564213 1567260 D Selenoprotein. identified by similarity to SP:P24183; match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM PF04879; match to protein family HMM TIGR01409; match to protein family HMM TIGR01553; formate dehydrogenase, nitrate inducible, alpha subunit, selenocysteine-containing 1564213..1567260 Escherichia coli HS 5594998 YP_001458268.1 CDS fdnH NC_009800.1 1567273 1568157 D identified by similarity to SP:P0AAJ3; match to protein family HMM PF00037; match to protein family HMM PF09163; match to protein family HMM TIGR01582; formate dehydrogenase, nitrate-inducible, iron-sulfur subunit 1567273..1568157 Escherichia coli HS 5592038 YP_001458269.1 CDS fdnI NC_009800.1 1568132 1568803 D nitrate-inducible, cytochrome b556(fdn) component of formate dehydrogenase; formate dehydrogenase-N subunit gamma 1568132..1568803 Escherichia coli HS 5592039 YP_001458270.1 CDS EcHS_A1560 NC_009800.1 1568888 1569040 D identified by glimmer; hypothetical protein 1568888..1569040 Escherichia coli HS 5592040 YP_001458271.1 CDS EcHS_A1562 NC_009800.1 1569210 1569494 R identified by match to protein family HMM PF01381; match to protein family HMM TIGR02607; addiction module antidote protein complement(1569210..1569494) Escherichia coli HS 5591797 YP_001458272.1 CDS EcHS_A1563 NC_009800.1 1569640 1570650 R similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase complement(1569640..1570650) Escherichia coli HS 5591798 YP_001458273.1 CDS sfcA NC_009800.1 1570784 1572481 R malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase complement(1570784..1572481) Escherichia coli HS 5591799 YP_001458274.1 CDS rpsV NC_009800.1 1572638 1572775 R protein D; stationary-phase-induced ribosome-associated; in Escherichia coli this protein becomes associated with the ribosome; expression increases during stationary phase; 30S ribosomal subunit S22 complement(1572638..1572775) Escherichia coli HS 5592213 YP_001458275.1 CDS EcHS_A1566 NC_009800.1 1572877 1573092 R identified by similarity to SP:P76127; biofilm-dependent modulation protein complement(1572877..1573092) Escherichia coli HS 5592214 YP_001458276.1 CDS osmC NC_009800.1 1573437 1573868 D identified by match to protein family HMM PF02566; peroxiredoxin OsmC 1573437..1573868 Escherichia coli HS 5592215 YP_001458277.1 CDS EcHS_A1568 NC_009800.1 1573924 1574850 R identified by match to protein family HMM PF00005; match to protein family HMM PF08352; match to protein family HMM TIGR01727; ABC transport system ATP-binding protein complement(1573924..1574850) Escherichia coli HS 5591953 YP_001458278.1 CDS EcHS_A1569 NC_009800.1 1574843 1575829 R identified by match to protein family HMM PF00005; match to protein family HMM PF08352; match to protein family HMM TIGR01727; ABC transporter ATP-binding protein complement(1574843..1575829) Escherichia coli HS 5591954 YP_001458279.1 CDS yddQ NC_009800.1 1575826 1576722 R identified by similarity to SP:P77463; match to protein family HMM PF00528; ATP-dependent peptide transporter membrane subunit complement(1575826..1576722) Escherichia coli HS 5591955 YP_001458280.1 CDS yddR NC_009800.1 1576719 1577741 R identified by similarity to SP:P77308; match to protein family HMM PF00528; ABC transporter permease complement(1576719..1577741) Escherichia coli HS 5592254 YP_001458281.1 CDS EcHS_A1572 NC_009800.1 1577743 1579293 R identified by similarity to SP:P76128; match to protein family HMM PF00496; ABC transporter periplasmic-binding protein yddS precursor complement(1577743..1579293) Escherichia coli HS 5592255 YP_001458282.1 CDS ddpX NC_009800.1 1579307 1579888 R catalyzes the hydrolysis of D-alanyl-D-alanine dipeptide: Zn dependent; involved in peptidoglycan synthesis; D-alanyl-D-alanine dipeptidase complement(1579307..1579888) Escherichia coli HS 5592256 YP_001458283.1 CDS dos NC_009800.1 1580146 1582569 R heme-regulated phosphodiesterase with phosphodiesterase activity with cAMP but not with cGMP, bis(p-nitrophenyl) phosphate or p-nitrophenyl phosphate; cAMP phosphodiesterase complement(1580146..1582569) Escherichia coli HS 5595149 YP_001458284.1 CDS EcHS_A1575 NC_009800.1 1582570 1583952 R identified by match to protein family HMM PF00990; match to protein family HMM TIGR00254; diguanylate cyclase complement(1582570..1583952) Escherichia coli HS 5595150 YP_001458285.1 CDS EcHS_A1576 NC_009800.1 1584329 1585648 R yddW; identified by match to protein family HMM PF02638; lipoprotein complement(1584329..1585648) Escherichia coli HS 5595151 YP_001458286.1 CDS gadC NC_009800.1 1585779 1587314 R identified by match to protein family HMM PF00324; match to protein family HMM TIGR00910; glutamate:gamma aminobutyrate antiporter complement(1585779..1587314) Escherichia coli HS 5594807 YP_001458287.1 CDS gadB NC_009800.1 1587470 1588870 R identified by match to protein family HMM PF00282; match to protein family HMM TIGR01788; glutamate decarboxylase GadB complement(1587470..1588870) Escherichia coli HS 5594808 YP_001458288.1 CDS pqqL NC_009800.1 1589233 1592013 R identified by match to protein family HMM PF00675; match to protein family HMM PF05193; M16B family peptidase complement(1589233..1592013) Escherichia coli HS 5594809 YP_001458289.1 CDS EcHS_A1580 NC_009800.1 1592070 1594442 R yddB; identified by match to protein family HMM PF00593; match to protein family HMM PF07715; match to protein family HMM TIGR03304; TonB-dependent receptor complement(1592070..1594442) Escherichia coli HS 5593894 YP_001458290.1 CDS EcHS_A1581 NC_009800.1 1594480 1596165 R yddA; identified by match to protein family HMM PF00005; match to protein family HMM PF05992; inner membrane ABC transporter ATP-binding protein complement(1594480..1596165) Escherichia coli HS 5593895 YP_001458291.1 CDS EcHS_A1582 NC_009800.1 1596456 1597613 R ydeM; identified by match to protein family HMM PF04055; radical SAM domain-containing protein complement(1596456..1597613) Escherichia coli HS 5593896 YP_001458292.1 CDS EcHS_A1583 NC_009800.1 1597665 1599347 R identified by match to protein family HMM PF00884; sulfatase complement(1597665..1599347) Escherichia coli HS 5593762 YP_001458293.1 CDS EcHS_A1584 NC_009800.1 1599749 1600510 R regulates the cellular response to acid resistance; transcriptional regulator YdeO complement(1599749..1600510) Escherichia coli HS 5593763 YP_001458294.1 CDS EcHS_A1585 NC_009800.1 1601030 1603309 R in Escherichia coli it may be involved in repression of type III secretion system (TTSS) genes of the host cell; involved with increased resistance to low pH; member of the prokaryotic molybdopterin-containing oxidoreductase; oxidoreductase complement(1601030..1603309) Escherichia coli HS 5593764 YP_001458295.1 CDS EcHS_A1586 NC_009800.1 1603643 1604557 R identified by similarity to SP:P08191; match to protein family HMM PF00419; match to protein family HMM PF09160; protein FimH-like protein complement(1603643..1604557) Escherichia coli HS 5592239 YP_001458296.1 CDS EcHS_A1587 NC_009800.1 1604616 1605119 R identified by similarity to SP:P08190; match to protein family HMM PF00419; protein fimG-like protein complement(1604616..1605119) Escherichia coli HS 5592240 YP_001458297.1 CDS EcHS_A1588 NC_009800.1 1605132 1605662 R identified by match to protein family HMM PF00419; protein FimF-like protein complement(1605132..1605662) Escherichia coli HS 5592241 YP_001458298.1 CDS EcHS_A1589 NC_009800.1 1605676 1606824 R identified by match to protein family HMM PF00577; fimbrial usher family protein complement(1605676..1606824) Escherichia coli HS 5591496 YP_001458299.1 CDS EcHS_A1590 NC_009800.1 1607677 1608999 R identified by similarity to SP:P23874; match to protein family HMM PF07804; match to protein family HMM PF07805; match to protein family HMM TIGR03071; protein HipA complement(1607677..1608999) Escherichia coli HS 5591497 YP_001458300.1 CDS hipB NC_009800.1 1608999 1609283 R identified by similarity to SP:P23873; match to protein family HMM PF01381; DNA-binding transcriptional regulator HipB complement(1608999..1609283) Escherichia coli HS 5591498 YP_001458301.1 CDS lsrK NC_009800.1 1615439 1617031 R identified by similarity to SP:P77432; match to protein family HMM PF00370; match to protein family HMM PF02782; autoinducer-2 (AI-2) kinase complement(1615439..1617031) Escherichia coli HS 5594897 YP_001458302.1 CDS lsrR NC_009800.1 1617110 1618063 R identified by similarity to SP:P76141; match to protein family HMM PF04198; transcriptional repressor LsrR complement(1617110..1618063) Escherichia coli HS 5594898 YP_001458303.1 CDS lsrA NC_009800.1 1618312 1619847 D identified by similarity to SP:P77257; match to protein family HMM PF00005; autoinducer-2 ABC transporter ATP-binding protein LsrA 1618312..1619847 Escherichia coli HS 5594319 YP_001458304.1 CDS lsrC NC_009800.1 1619841 1620869 D identified by similarity to SP:P77672; match to protein family HMM PF02653; autoinducer-2 ABC transporter permease LsrC 1619841..1620869 Escherichia coli HS 5594320 YP_001458305.1 CDS lsrD NC_009800.1 1620869 1621861 D identified by similarity to SP:P0AFS1; match to protein family HMM PF02653; autoinducer-2 ABC transporter permease LsrD 1620869..1621861 Escherichia coli HS 5594321 YP_001458306.1 CDS lsrB NC_009800.1 1621873 1622895 D identified by similarity to SP:P76142; autoinducer-2 ABC transporter periplasmic autoinducer-2-binding protein LsrB 1621873..1622895 Escherichia coli HS 5591616 YP_001458307.1 CDS lsrF NC_009800.1 1622922 1623797 D identified by similarity to SP:P76143; match to protein family HMM PF01791; aldolase 1622922..1623797 Escherichia coli HS 5591617 YP_001458308.1 CDS lsrG NC_009800.1 1623821 1624111 D yneC; identified by similarity to SP:P64461; match to protein family HMM PF03992; autoinducer-2 (AI-2) modifying protein LsrG 1623821..1624111 Escherichia coli HS 5591618 YP_001458309.1 CDS tam NC_009800.1 1624168 1624926 D catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate; trans-aconitate 2-methyltransferase 1624168..1624926 Escherichia coli HS 5591389 YP_001458310.1 CDS EcHS_A1602 NC_009800.1 1624930 1625895 R yneE; identified by match to protein family HMM PF05249; hypothetical protein complement(1624930..1625895) Escherichia coli HS 5591390 YP_001458311.1 CDS uxaB NC_009800.1 1626051 1627502 R catalyzes the formation of D-tagaturonate from D-altronate; altronate oxidoreductase complement(1626051..1627502) Escherichia coli HS 5591391 YP_001458312.1 CDS EcHS_A1604 NC_009800.1 1627729 1628568 R identified by match to protein family HMM PF00990; match to protein family HMM TIGR00254; diguanylate cyclase complement(1627729..1628568) Escherichia coli HS 5592552 YP_001458313.1 CDS EcHS_A1605 NC_009800.1 1628788 1629147 R yneG; identified by similarity to GB:AAN80403.1; hypothetical protein complement(1628788..1629147) Escherichia coli HS 5592553 YP_001458314.1 CDS glsA2 NC_009800.1 1629147 1630073 R catalyzes the formation of glutamate from glutamine; glutaminase complement(1629147..1630073) Escherichia coli HS 5592554 YP_001458315.1 CDS EcHS_A1607 NC_009800.1 1630137 1631525 R in Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase; succinate semialdehyde dehydrogenase complement(1630137..1631525) Escherichia coli HS 5594292 YP_001458316.1 CDS EcHS_A1608 NC_009800.1 1631626 1632507 D identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator 1631626..1632507 Escherichia coli HS 5594293 YP_001458317.1 CDS EcHS_A1609 NC_009800.1 1632585 1633700 D yneK; identified by similarity to GB:AAP17050.1; hypothetical protein 1632585..1633700 Escherichia coli HS 5594294 YP_001458318.1 CDS sotB NC_009800.1 1633850 1635040 D identified by similarity to SP:Q9S3J9; match to protein family HMM PF07690; sugar efflux transporter 1633850..1635040 Escherichia coli HS 5592684 YP_001458319.1 CDS marC NC_009800.1 1635065 1635730 R protein involved in resistance to different drugs (tetracycline, chloramphenicol, beta-lactams, and quinolones); part of the multiple antibiotic resistance (mar) locus, which is composed by the genes marC and marRAB; unknown function; multiple drug resistance protein MarC complement(1635065..1635730) Escherichia coli HS 5592685 YP_001458320.1 CDS marR NC_009800.1 1635941 1636375 D Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes; DNA-binding transcriptional repressor MarR 1635941..1636375 Escherichia coli HS 5592686 YP_001458321.1 CDS celA NC_009800.1 1637085 1638524 R converts 6-phospho-beta-D-glucosyl-(1,4)-D-glucose to glucose and glucose 6-phosphate; required for cellobiose uptake and metabolism; 6-phospho-beta-glucosidase complement(1637085..1638524) Escherichia coli HS 5592139 YP_001458322.1 CDS EcHS_A1618 NC_009800.1 1640277 1640588 R identified by match to protein family HMM PF02255; PTS system lactose/cellobiose-specific family IIA subunit complement(1640277..1640588) Escherichia coli HS 5593528 YP_001458323.1 CDS EcHS_A1619 NC_009800.1 1640616 1641929 R identified by match to protein family HMM PF02378; match to protein family HMM TIGR00410; PTS system lactose/cellobiose family IIC subunit complement(1640616..1641929) Escherichia coli HS 5593529 YP_001458324.1 CDS EcHS_A1620 NC_009800.1 1642053 1642364 R identified by match to protein family HMM PF02302; PTS system lactose/cellobiose family IIB subunit complement(1642053..1642364) Escherichia coli HS 5591845 YP_001458325.1 CDS EcHS_A1621 NC_009800.1 1642563 1643282 D identified by match to protein family HMM PF00392; match to protein family HMM PF07702; GntR family transcriptional regulator 1642563..1643282 Escherichia coli HS 5591846 YP_001458326.1 CDS eamA NC_009800.1 1643305 1644204 R identified by match to protein family HMM PF00892; match to protein family HMM PF03151; O-acetylserine/cysteine export protein complement(1643305..1644204) Escherichia coli HS 5591847 YP_001458327.1 CDS ydeE NC_009800.1 1644399 1645586 D YdeF; uncharacterized member of the major facilitator superfamily (MFS) of transporters; MFS-type transporter YdeE 1644399..1645586 Escherichia coli HS 5592610 YP_001458328.1 CDS EcHS_A1624 NC_009800.1 1645713 1645808 D identified by similarity to GB:AAV77284.1; hypothetical protein 1645713..1645808 Escherichia coli HS 5592611 YP_001458329.1 CDS EcHS_A1625 NC_009800.1 1646027 1646917 R identified by match to protein family HMM PF00990; match to protein family HMM TIGR00254; hypothetical protein complement(1646027..1646917) Escherichia coli HS 5592612 YP_001458330.1 CDS EcHS_A1626 NC_009800.1 1647172 1647564 R ydeI; identified by match to protein family HMM PF04076; match to protein family HMM TIGR00156; hypothetical protein complement(1647172..1647564) Escherichia coli HS 5591255 YP_001458331.1 CDS EcHS_A1627 NC_009800.1 1647840 1648358 D ydeJ; identified by match to protein family HMM PF02464; match to protein family HMM TIGR00199; competence damage-inducible protein A 1647840..1648358 Escherichia coli HS 5591256 YP_001458332.1 CDS dcp NC_009800.1 1648403 1650448 R identified by similarity to SP:P24171; match to protein family HMM PF01432; dipeptidyl carboxypeptidase II complement(1648403..1650448) Escherichia coli HS 5591257 YP_001458333.1 CDS EcHS_A1629 NC_009800.1 1650585 1651331 D NADP(+)-dependent; catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine; 3-hydroxy acid dehydrogenase 1650585..1651331 Escherichia coli HS 5592140 YP_001458334.1 CDS EcHS_A1630 NC_009800.1 1651420 1652106 D ydfH; identified by match to protein family HMM PF00392; match to protein family HMM PF07729; GntR family transcriptional regulator 1651420..1652106 Escherichia coli HS 5592141 YP_001458335.1 CDS EcHS_A1631 NC_009800.1 1652241 1652513 R identified by glimmer; hypothetical protein complement(1652241..1652513) Escherichia coli HS 5592142 YP_001458336.1 CDS EcHS_A1632 NC_009800.1 1652522 1653982 R identified by match to protein family HMM PF01232; match to protein family HMM PF08125; mannitol dehydrogenase complement(1652522..1653982) Escherichia coli HS 5595031 YP_001458337.1 CDS ydfJ NC_009800.1 1654071 1655354 R identified by similarity to SP:P77228; match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM TIGR00883; inner membrane metabolite transport protein ydfJ complement(1654071..1655354) Escherichia coli HS 5595032 YP_001458338.1 CDS EcHS_A1634 NC_009800.1 1656105 1656371 D ydfK; identified by glimmer; hypothetical protein 1656105..1656371 Escherichia coli HS 5595033 YP_001458339.1 CDS pinR NC_009800.1 1656688 1657278 D identified by match to protein family HMM PF00239; match to protein family HMM PF02796; site-specific recombinase resolvase PinR 1656688..1657278 Escherichia coli HS 5595184 YP_001458340.1 CDS EcHS_A1636 NC_009800.1 1657376 1657468 R identified by similarity to SP:P03740; tail fiber assembly protein, truncation complement(1657376..1657468) Escherichia coli HS 5595185 YP_001458341.1 CDS EcHS_A1637 NC_009800.1 1657550 1661326 R phage protein-like; identified by match to protein family HMM PF08400; L-shaped tail fiber protein complement(1657550..1661326) Escherichia coli HS 5595186 YP_001458342.1 CDS EcHS_A1638 NC_009800.1 1661391 1661990 R identified by match to protein family HMM PF06316; match to protein family HMM TIGR03304; entero Ail/Lom family protein complement(1661391..1661990) Escherichia coli HS 5593270 YP_001458343.1 CDS EcHS_A1639 NC_009800.1 1662058 1664703 R identified by match to protein family HMM PF00041; match to protein family HMM PF09327; fibronectin type III complement(1662058..1664703) Escherichia coli HS 5593271 YP_001458344.1 CDS EcHS_A1640 NC_009800.1 1665089 1665616 R phage protein DUF1441; hypothetical protein complement(1665089..1665616) Escherichia coli HS 5593272 YP_001458345.1 CDS EcHS_A1641 NC_009800.1 1666666 1666842 R identified by match to protein family HMM PF08178; GnsA/GnsB family transcriptional regulator complement(1666666..1666842) Escherichia coli HS 5593068 YP_001458346.1 CDS EcHS_A1642 NC_009800.1 1667514 1667729 R identified by match to protein family HMM PF00313; cold shock DNA-binding protein complement(1667514..1667729) Escherichia coli HS 5593069 YP_001458347.1 CDS EcHS_A1643 NC_009800.1 1668090 1668587 R hypothetical protein complement(1668090..1668587) Escherichia coli HS 5593070 YP_001458348.1 CDS EcHS_A1644 NC_009800.1 1668584 1669117 R identified by match to protein family HMM PF00959; phage lysozyme complement(1668584..1669117) Escherichia coli HS 5593689 YP_001458349.1 CDS EcHS_A1645 NC_009800.1 1669439 1669990 R identified by similarity to GB:AAP15758.1; match to protein family HMM PF07041; hypothetical protein complement(1669439..1669990) Escherichia coli HS 5593690 YP_001458350.1 CDS EcHS_A1646 NC_009800.1 1669995 1670210 R identified by match to protein family HMM PF04971; lambda phage S protein family protein complement(1669995..1670210) Escherichia coli HS 5593691 YP_001458351.1 CDS EcHS_A1647 NC_009800.1 1670401 1671114 R identified by match to protein family HMM PF00165; AraC family transcriptional regulator complement(1670401..1671114) Escherichia coli HS 5594024 YP_001458352.1 CDS EcHS_A1648 NC_009800.1 1671521 1672480 R DUF523 pathogenicity island protein-like; identified by match to protein family HMM PF04463; match to protein family HMM PF08349; hypothetical protein complement(1671521..1672480) Escherichia coli HS 5594025 YP_001458353.1 CDS EcHS_A1649 NC_009800.1 1673353 1673730 R identified by similarity to SP:Q47274; match to protein family HMM PF06530; phage antitermination Q complement(1673353..1673730) Escherichia coli HS 5594026 YP_001458354.1 CDS EcHS_A1650 NC_009800.1 1673845 1673955 D ydfA; hypothetical protein 1673845..1673955 Escherichia coli HS 5594151 YP_001458355.1 CDS EcHS_A1651 NC_009800.1 1674458 1674961 R identified by match to protein family HMM PF03400; IS1, transposase orfB complement(1674458..1674961) Escherichia coli HS 5594152 YP_001458356.1 CDS EcHS_A1652 NC_009800.1 1674880 1675155 R identified by match to protein family HMM PF03811; IS1, transposase orfA complement(1674880..1675155) Escherichia coli HS 5594153 YP_001458357.1 CDS EcHS_A1653 NC_009800.1 1675184 1676050 R identified by similarity to SP:P38105; match to protein family HMM PF00107; match to protein family HMM PF08240; starvation sensing protein RspB complement(1675184..1676050) Escherichia coli HS 5594636 YP_001458358.1 CDS rspA NC_009800.1 1676062 1677276 R identified by similarity to SP:P38104; match to protein family HMM PF01188; match to protein family HMM PF02746; starvation-sensing protein RspA complement(1676062..1677276) Escherichia coli HS 5594637 YP_001458359.1 CDS EcHS_A1655 NC_009800.1 1677482 1677808 R identified by match to protein family HMM PF02694; hypothetical protein complement(1677482..1677808) Escherichia coli HS 5594638 YP_001458360.1 CDS EcHS_A1656 NC_009800.1 1677943 1678284 D identified by match to protein family HMM PF06932; hypothetical protein 1677943..1678284 Escherichia coli HS 5594206 YP_001458361.1 CDS speG NC_009800.1 1678319 1678879 D identified by similarity to SP:P0A951; match to protein family HMM PF00583; diamine N-acetyltransferase 1678319..1678879 Escherichia coli HS 5594207 YP_001458362.1 CDS EcHS_A1658 NC_009800.1 1678882 1679628 R ynfC; identified by match to protein family HMM PF06788; hypothetical protein complement(1678882..1679628) Escherichia coli HS 5594208 YP_001458363.1 CDS EcHS_A1659 NC_009800.1 1679700 1680005 D identified by match to protein family HMM PF06649; hypothetical protein 1679700..1680005 Escherichia coli HS 5594467 YP_001458364.1 CDS ynfE NC_009800.1 1680204 1682630 D identified by match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM PF04879; match to protein family HMM TIGR01409; match to protein family HMM TIGR02166; anaerobic dimethyl sulfoxide reductase, A subunit YnfE 1680204..1682630 Escherichia coli HS 5594468 YP_001458365.1 CDS EcHS_A1661 NC_009800.1 1682691 1685114 D identified by match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM PF04879; match to protein family HMM TIGR01409; match to protein family HMM TIGR02166; anaerobic dimethyl sulfoxide reductase, A subunit 1682691..1685114 Escherichia coli HS 5594469 YP_001458366.1 CDS dmsB1 NC_009800.1 1685125 1685742 D identified by similarity to SP:P18776; match to protein family HMM PF00037; match to protein family HMM TIGR02951; dimethylsulfoxide reductase, B subunit 1685125..1685742 Escherichia coli HS 5593917 YP_001458367.1 CDS dmsC2 NC_009800.1 1685744 1686598 D identified by match to protein family HMM PF04976; anaerobic dimethyl sulfoxide reductase, C subunit 1685744..1686598 Escherichia coli HS 5593918 YP_001458368.1 CDS dmsD NC_009800.1 1686641 1687255 D binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane; twin-argninine leader-binding protein DmsD 1686641..1687255 Escherichia coli HS 5593919 YP_001458369.1 CDS EcHS_A1665 NC_009800.1 1687276 1687383 D identified by glimmer; hypothetical protein 1687276..1687383 Escherichia coli HS 5593426 YP_001458370.1 CDS EcHS_A1666 NC_009800.1 1687450 1688706 D identified by match to protein family HMM PF00654; voltage-gated ClC-type chloride channel ClcB 1687450..1688706 Escherichia coli HS 5593427 YP_001458371.1 CDS bioD2 NC_009800.1 1688659 1689354 R DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase complement(1688659..1689354) Escherichia coli HS 5593428 YP_001458372.1 CDS mic NC_009800.1 1689479 1690699 R identified by similarity to SP:P50456; match to protein family HMM PF00480; transcriptional regulator Mic complement(1689479..1690699) Escherichia coli HS 5595212 YP_001458373.1 CDS EcHS_A1669 NC_009800.1 1690834 1691727 R identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator complement(1690834..1691727) Escherichia coli HS 5595213 YP_001458374.1 CDS ynfM NC_009800.1 1691834 1693087 D identified by match to protein family HMM PF07690; major facilitator family transporter 1691834..1693087 Escherichia coli HS 5595214 YP_001458375.1 CDS EcHS_A1671 NC_009800.1 1693484 1693819 D required for growth and survival under moderately acid conditions; acid shock protein precursor 1693484..1693819 Escherichia coli HS 5595256 YP_001458376.1 CDS EcHS_A1672 NC_009800.1 1694095 1694916 D identified by match to protein family HMM PF00089; S1A family peptidase 1694095..1694916 Escherichia coli HS 5595257 YP_001458377.1 CDS mdtI NC_009800.1 1694955 1695284 R with MdtJ is involved in resistance to deoxycholate, nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtI complement(1694955..1695284) Escherichia coli HS 5595258 YP_001458378.1 CDS mdtJ NC_009800.1 1695271 1695636 R with MdtI is involved in resistance to deoxycholate , nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtJ complement(1695271..1695636) Escherichia coli HS 5593189 YP_001458379.1 CDS tqsA NC_009800.1 1696048 1697082 D transport of quorum-sensing signal; mutations in this gene alters the transport of the quorum-sensing signal autoinducer 2 (AI-2) which affects expression of a large number of genes; transport protein 1696048..1697082 Escherichia coli HS 5593190 YP_001458380.1 CDS pntB NC_009800.1 1697107 1698495 R catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme; pyridine nucleotide transhydrogenase complement(1697107..1698495) Escherichia coli HS 5593191 YP_001458381.1 CDS pntA NC_009800.1 1698506 1700038 R forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm; NAD(P) transhydrogenase subunit alpha complement(1698506..1700038) Escherichia coli HS 5592872 YP_001458382.1 CDS EcHS_A1678 NC_009800.1 1700461 1700571 D identified by glimmer; hypothetical protein 1700461..1700571 Escherichia coli HS 5592873 YP_001458383.1 CDS ydgH NC_009800.1 1700561 1701505 D identified by match to protein family HMM PF07338; hypothetical protein 1700561..1701505 Escherichia coli HS 5592874 YP_001458384.1 CDS arcD NC_009800.1 1701691 1703073 D identified by match to protein family HMM PF00324; match to protein family HMM TIGR00905; arginine/ornithine antiporter 1701691..1703073 Escherichia coli HS 5592663 YP_001458385.1 CDS EcHS_A1681 NC_009800.1 1703110 1703832 D identified by match to protein family HMM PF00106; short chain dehydrogenase 1703110..1703832 Escherichia coli HS 5592664 YP_001458386.1 CDS EcHS_A1682 NC_009800.1 1703829 1704164 R ydgC; identified by match to protein family HMM PF06942; hypothetical protein complement(1703829..1704164) Escherichia coli HS 5592665 YP_001458387.1 CDS rstA NC_009800.1 1704293 1705012 D response regulator in two-component regulatory system with RstB; DNA-binding transcriptional regulator RstA 1704293..1705012 Escherichia coli HS 5592576 YP_001458388.1 CDS rstB NC_009800.1 1705016 1706317 D identified by similarity to SP:P18392; match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; sensor protein RstB 1705016..1706317 Escherichia coli HS 5592577 YP_001458389.1 CDS tus NC_009800.1 1706393 1707322 D binds to DNA replication terminator sequences to prevent passage of replication forks; DNA replication terminus site-binding protein 1706393..1707322 Escherichia coli HS 5592578 YP_001458390.1 CDS fumC NC_009800.1 1707319 1708722 R class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase complement(1707319..1708722) Escherichia coli HS 5591273 YP_001458391.1 CDS fumA NC_009800.1 1708865 1710511 R identified by similarity to SP:P0AC33; match to protein family HMM PF05681; match to protein family HMM PF05683; match to protein family HMM TIGR00722; match to protein family HMM TIGR00723; fumarate hydratase complement(1708865..1710511) Escherichia coli HS 5591274 YP_001458392.1 CDS manA NC_009800.1 1710710 1711885 D identified by match to protein family HMM PF01238; match to protein family HMM TIGR00218; mannose-6-phosphate isomerase 1710710..1711885 Escherichia coli HS 5591275 YP_001458393.1 CDS EcHS_A1689 NC_009800.1 1711986 1713494 D ydgA; identified by match to protein family HMM PF06097; hypothetical protein 1711986..1713494 Escherichia coli HS 5592050 YP_001458394.1 CDS uidC NC_009800.1 1713539 1714804 R identified by similarity to SP:Q47706; outer membrane porin protein complement(1713539..1714804) Escherichia coli HS 5592051 YP_001458395.1 CDS uidB NC_009800.1 1714843 1716216 R identified by similarity to SP:P30868; match to protein family HMM PF07690; match to protein family HMM TIGR00792; glucuronide transporter complement(1714843..1716216) Escherichia coli HS 5592052 YP_001458396.1 CDS uidA NC_009800.1 1716213 1718024 R identified by similarity to SP:P05804; match to protein family HMM PF00703; match to protein family HMM PF02836; match to protein family HMM PF02837; beta-D-glucuronidase complement(1716213..1718024) Escherichia coli HS 5591015 YP_001458397.1 CDS uidR NC_009800.1 1718415 1719005 R identified by match to protein family HMM PF00440; transcriptional regulator UidR complement(1718415..1719005) Escherichia coli HS 5591016 YP_001458398.1 CDS EcHS_A1694 NC_009800.1 1719226 1719993 R Acts on the hydroxyl group at position 7 of the steroid frame; 7-alpha-hydroxysteroid dehydrogenase complement(1719226..1719993) Escherichia coli HS 5591017 YP_001458399.1 CDS malI NC_009800.1 1720105 1721133 R regulates malXY which are involved in maltose-glucose transport; DNA-binding transcriptional repressor MalI complement(1720105..1721133) Escherichia coli HS 5591854 YP_001458400.1 CDS malX NC_009800.1 1721308 1722900 D phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS); catalyzes the phosphorylation of maltose and glucose concomitant with their translocation across the cell membrane; component IIB catalyzes the phosphorylation of the sugar molecule; IIC forms the translocation channel and contains the substrate specific binding site; bifunctional maltose and glucose-specific PTS system components IICB 1721308..1722900 Escherichia coli HS 5591855 YP_001458401.1 CDS malY NC_009800.1 1722910 1724082 D identified by similarity to SP:P23256; match to protein family HMM PF00155; MalY protein 1722910..1724082 Escherichia coli HS 5591856 YP_001458402.1 CDS add NC_009800.1 1724186 1725187 D catalyzes the formation of inosine from adenosine; adenosine deaminase 1724186..1725187 Escherichia coli HS 5590945 YP_001458403.1 CDS EcHS_A1699 NC_009800.1 1725221 1726300 R identified by match to protein family HMM PF01118; match to protein family HMM PF01408; match to protein family HMM PF02894; oxidoreductase complement(1725221..1726300) Escherichia coli HS 5590946 YP_001458404.1 CDS blr NC_009800.1 1726504 1726629 D identified by similarity to SP:P56976; beta-lactam resistance protein 1726504..1726629 Escherichia coli HS 5590947 YP_001458405.1 CDS EcHS_A1701 NC_009800.1 1726902 1727117 D YdgT; in E. coli, when complexed with H-NS or StpA binds a 26 base-pair DNA sequence of oriC; seems to play a role in optimizing the activity of oriC; non-essential; Hha protein paralog; in an hha mutant background, cnu is overexpressed and can compensate hha-induced phenotypes; oriC-binding nucleoid-associated protein 1726902..1727117 Escherichia coli HS 5594867 YP_001458406.1 CDS EcHS_A1702 NC_009800.1 1727203 1727643 D hypothetical protein 1727203..1727643 Escherichia coli HS 5594868 YP_001458407.1 CDS rnfA NC_009800.1 1727720 1728301 D identified by match to protein family HMM PF02508; match to protein family HMM TIGR01943; Na(+)-translocating NADH-quinone reductase subunit E 1727720..1728301 Escherichia coli HS 5594869 YP_001458408.1 CDS rnfB NC_009800.1 1728301 1728879 D part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfB 1728301..1728879 Escherichia coli HS 5595514 YP_001458409.1 CDS rnfC NC_009800.1 1728872 1731094 D part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfC 1728872..1731094 Escherichia coli HS 5595515 YP_001458410.1 CDS rnfD NC_009800.1 1731095 1732153 D RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents; electron transport complex protein RnfD 1731095..1732153 Escherichia coli HS 5595516 YP_001458411.1 CDS rnfG NC_009800.1 1732157 1732777 D part of membrane-bound complex hought to be involved in electron transport to nitrogen; electron transport complex protein RnfG 1732157..1732777 Escherichia coli HS 5591545 YP_001458412.1 CDS rnfE NC_009800.1 1732781 1733476 D in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase; electron transport complex RsxE subunit 1732781..1733476 Escherichia coli HS 5591546 YP_001458413.1 CDS nth NC_009800.1 1733476 1734111 D DNA-(apurinic or apyrimidinic site) lyase; has apurinic or apyrimidinic endonuclease activity and DNA N-glycosylase activity; removed damaged DNA at cytosines, thymines and guanines; endonuclease III 1733476..1734111 Escherichia coli HS 5591547 YP_001458414.1 CDS tppB NC_009800.1 1734722 1736224 D mutations in this gene confer resistance to the toxic peptide alafosfalin in Salmonella typhimurium; member of proton-dependent oligopeptide transport (POT) system family; in Escherichia coli this gene is regulated by OmpR although not via osmoregulation; tripeptide transporter permease 1734722..1736224 Escherichia coli HS 5594864 YP_001458415.1 CDS EcHS_A1711 NC_009800.1 1736330 1736935 D identified by match to protein family HMM PF00043; match to protein family HMM PF02798; glutathionine S-transferase 1736330..1736935 Escherichia coli HS 5594865 YP_001458416.1 CDS pdxY NC_009800.1 1736979 1737839 R catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxamine kinase complement(1736979..1737839) Escherichia coli HS 5594866 YP_001458417.1 CDS tyrS NC_009800.1 1737901 1739175 R catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase complement(1737901..1739175) Escherichia coli HS 5591123 YP_001458418.1 CDS pdxH NC_009800.1 1739304 1739960 R catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase complement(1739304..1739960) Escherichia coli HS 5591124 YP_001458419.1 CDS EcHS_A1715 NC_009800.1 1740019 1740342 R MliC; membrane-bound lysozyme inhibitor of c-type lysozyme; lysozyme inhibitor complement(1740019..1740342) Escherichia coli HS 5591125 YP_001458420.1 CDS anmK NC_009800.1 1740446 1741555 R catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling; anhydro-N-acetylmuramic acid kinase complement(1740446..1741555) Escherichia coli HS 5593048 YP_001458421.1 CDS slyB NC_009800.1 1741829 1742296 D identified by similarity to SP:P0A1X0; match to protein family HMM PF05433; outer membrane lipoprotein SlyB 1741829..1742296 Escherichia coli HS 5593049 YP_001458422.1 CDS EcHS_A1718 NC_009800.1 1742343 1742777 R Transcription regulator that can both activate or repress expression; transcriptional regulator SlyA complement(1742343..1742777) Escherichia coli HS 5593050 YP_001458423.1 CDS EcHS_A1719 NC_009800.1 1742802 1742921 R identified by glimmer; hypothetical protein complement(1742802..1742921) Escherichia coli HS 5594190 YP_001458424.1 CDS EcHS_A1720 NC_009800.1 1742978 1743214 D identified by match to protein family HMM PF07869; hypothetical protein 1742978..1743214 Escherichia coli HS 5594191 YP_001458425.1 CDS EcHS_A1721 NC_009800.1 1743217 1744074 D identified by match to protein family HMM PF00529; MFP family transporter 1743217..1744074 Escherichia coli HS 5594192 YP_001458426.1 CDS EcHS_A1722 NC_009800.1 1744074 1746086 D NULL; identified by match to protein family HMM PF04632; fusaric acid resistance domain-containing protein 1744074..1746086 Escherichia coli HS 5594887 YP_001458427.1 CDS sodC NC_009800.1 1746087 1746608 R SodC; copper and zinc binding; converts superoxide radicals to hydrogen peroxide and water; superoxide dismutase complement(1746087..1746608) Escherichia coli HS 5594888 YP_001458428.1 CDS ydhF NC_009800.1 1746689 1747585 R NULL; identified by similarity to SP:P76187; match to protein family HMM PF00248; oxidoreductase YdhF complement(1746689..1747585) Escherichia coli HS 5594889 YP_001458429.1 CDS EcHS_A1725 NC_009800.1 1747645 1747764 D identified by glimmer; hypothetical protein 1747645..1747764 Escherichia coli HS 5593775 YP_001458430.1 CDS EcHS_A1726 NC_009800.1 1747976 1748575 D identified by match to protein family HMM PF00440; TetR family transcriptional regulator 1747976..1748575 Escherichia coli HS 5593776 YP_001458431.1 CDS nemA NC_009800.1 1748610 1749707 D FMN-linked; catalyzes the formation of N-ethylsuccinimide from N-ethylmaleimide; N-ethylmaleimide reductase 1748610..1749707 Escherichia coli HS 5593777 YP_001458432.1 CDS gloA NC_009800.1 1749788 1750195 D Ni-dependent; catalyzes the formation of S-lactoylglutathione from methylglyoxal and glutathione; glyoxalase I 1749788..1750195 Escherichia coli HS 5590948 YP_001458433.1 CDS rnt NC_009800.1 1750298 1750945 D Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A); ribonuclease T 1750298..1750945 Escherichia coli HS 5590949 YP_001458434.1 CDS EcHS_A1731 NC_009800.1 1750976 1751086 R identified by glimmer; hypothetical protein complement(1750976..1751086) Escherichia coli HS 5590950 YP_001458435.1 CDS lhr NC_009800.1 1751077 1755654 D similar to the DNA and RNA helicase superfamily II and eukaryotic DEAD family of helicases; longest known protein in E. coli; ATP-dependent helicase Lhr 1751077..1755654 Escherichia coli HS 5593961 YP_001458436.1 CDS EcHS_A1732 NC_009800.1 1755705 1756052 R identified by similarity to SP:P0AC69; match to protein family HMM PF00462; match to protein family HMM TIGR00365; hypothetical protein complement(1755705..1756052) Escherichia coli HS 5593962 YP_001458437.1 CDS EcHS_A1733 NC_009800.1 1756134 1756286 R identified by glimmer; hypothetical protein complement(1756134..1756286) Escherichia coli HS 5593963 YP_001458438.1 CDS EcHS_A1734 NC_009800.1 1756386 1757201 D identified by match to protein family HMM PF00877; NlpC/P60 family protein 1756386..1757201 Escherichia coli HS 5592399 YP_001458439.1 CDS sodB NC_009800.1 1757329 1757910 D SodB; iron binding; present under aerobic and anaerobic conditions; destroys free radicals; superoxide dismutase 1757329..1757910 Escherichia coli HS 5592400 YP_001458440.1 CDS EcHS_A1736 NC_009800.1 1758145 1759314 R identified by match to protein family HMM PF07690; major facilitator transporter complement(1758145..1759314) Escherichia coli HS 5592401 YP_001458441.1 CDS EcHS_A1737 NC_009800.1 1759480 1759599 R identified by glimmer; hypothetical protein complement(1759480..1759599) Escherichia coli HS 5594730 YP_001458442.1 CDS purR NC_009800.1 1759868 1760893 D binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers; DNA-binding transcriptional repressor PurR 1759868..1760893 Escherichia coli HS 5594731 YP_001458443.1 CDS EcHS_A1739 NC_009800.1 1760890 1761822 R identified by match to protein family HMM PF00126; match to protein family HMM PF03466; DNA-binding transcriptional regulator complement(1760890..1761822) Escherichia coli HS 5594732 YP_001458444.1 CDS EcHS_A1740 NC_009800.1 1761935 1763146 D uncharacterized member of the major facilitator superfamily (MFS); inner membrane transport protein YdhC 1761935..1763146 Escherichia coli HS 5593840 YP_001458445.1 CDS cfa NC_009800.1 1763437 1764585 D catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge; cyclopropane fatty acyl phospholipid synthase 1763437..1764585 Escherichia coli HS 5593841 YP_001458446.1 CDS ribE NC_009800.1 1764625 1765266 R catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha complement(1764625..1765266) Escherichia coli HS 5593842 YP_001458447.1 CDS EcHS_A1743 NC_009800.1 1765481 1766854 D NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones; multidrug efflux protein 1765481..1766854 Escherichia coli HS 5591252 YP_001458448.1 CDS EcHS_A1744 NC_009800.1 1766895 1768151 R ydhQ; hypothetical protein complement(1766895..1768151) Escherichia coli HS 5591253 YP_001458449.1 CDS EcHS_A1745 NC_009800.1 1768353 1768448 R identified by glimmer; hypothetical protein complement(1768353..1768448) Escherichia coli HS 5591254 YP_001458450.1 CDS ydhR NC_009800.1 1768724 1769029 D identified by similarity to SP:P0ACX4; match to protein family HMM PF08803; hypothetical protein 1768724..1769029 Escherichia coli HS 5591384 YP_001458451.1 CDS EcHS_A1749 NC_009800.1 1769155 1770759 D hypothetical protein 1769155..1770759 Escherichia coli HS 5591385 YP_001458452.1 CDS EcHS_A1750 NC_009800.1 1770972 1771718 D identified by similarity to GB:AAN80523.1; hypothetical protein 1770972..1771718 Escherichia coli HS 5591320 YP_001458453.1 CDS EcHS_A1751 NC_009800.1 1771587 1772372 R ydhU; identified by match to protein family HMM PF01292; nickel-dependent hydrogenase, b-type cytochrome subunit complement(1771587..1772372) Escherichia coli HS 5591321 YP_001458454.1 CDS EcHS_A1752 NC_009800.1 1772369 1773088 R identified by match to protein family HMM PF00037; (Fe-S)-binding protein complement(1772369..1773088) Escherichia coli HS 5591322 YP_001458455.1 CDS EcHS_A1753 NC_009800.1 1773101 1773748 R identified by similarity to GB:AAZ88187.1; hypothetical protein complement(1773101..1773748) Escherichia coli HS 5591361 YP_001458456.1 CDS EcHS_A1754 NC_009800.1 1773752 1775854 R identified by match to protein family HMM PF01314; match to protein family HMM PF02730; oxidoreductase complement(1773752..1775854) Escherichia coli HS 5591362 YP_001458457.1 CDS EcHS_A1755 NC_009800.1 1775875 1776501 R identified by match to protein family HMM PF00037; hypothetical protein complement(1775875..1776501) Escherichia coli HS 5591363 YP_001458458.1 CDS EcHS_A1756 NC_009800.1 1776956 1777165 R hypothetical protein complement(1776956..1777165) Escherichia coli HS 5591392 YP_001458459.1 CDS pykF NC_009800.1 1777722 1779134 D catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1777722..1779134 Escherichia coli HS 5591393 YP_001458460.1 CDS lpp NC_009800.1 1779445 1779681 D identified by similarity to SP:P69776; match to protein family HMM PF04728; major outer membrane lipoprotein 1779445..1779681 Escherichia coli HS 5591394 YP_001458461.1 CDS EcHS_A1759 NC_009800.1 1779745 1780749 R identified by match to protein family HMM PF01476; match to protein family HMM PF03734; LysM/ErfK/YbiS/YcfS/YnhG family protein complement(1779745..1780749) Escherichia coli HS 5591452 YP_001458462.1 CDS sufE NC_009800.1 1780898 1781314 R Acts with SufS to catalyze the formation of L-alanine from L-cysteine; cysteine desufuration protein SufE complement(1780898..1781314) Escherichia coli HS 5591453 YP_001458463.1 CDS sufS NC_009800.1 1781327 1782547 R catalyzes the formation of L-alanine and selenide or sulfanylcysteine from selenocysteine or cysteine; bifunctional cysteine desulfurase/selenocysteine lyase complement(1781327..1782547) Escherichia coli HS 5591454 YP_001458464.1 CDS sufD NC_009800.1 1782544 1783815 R with SufBC activates cysteine desulfurase SufS; cysteine desulfurase activator complex subunit SufD complement(1782544..1783815) Escherichia coli HS 5595018 YP_001458465.1 CDS sufC NC_009800.1 1783790 1784536 R part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE; cysteine desulfurase ATPase component complement(1783790..1784536) Escherichia coli HS 5595019 YP_001458466.1 CDS sufB NC_009800.1 1784546 1786033 R with SufCD activates cysteine desulfurase SufS; cysteine desulfurase activator complex subunit SufB complement(1784546..1786033) Escherichia coli HS 5595020 YP_001458467.1 CDS sufA NC_009800.1 1786042 1786410 R functions as a scaffold on which iron-sulfur clusters ([2Fe-2S]; [4Fe-4S]) are assembled; forms a homodimer; similar to IscA protein; iron-sulfur cluster assembly scaffold protein complement(1786042..1786410) Escherichia coli HS 5591372 YP_001458468.1 CDS EcHS_A1766 NC_009800.1 1786958 1787227 R identified by similarity to SP:P64478; hypothetical protein complement(1786958..1787227) Escherichia coli HS 5591374 YP_001458469.1 CDS ydiL NC_009800.1 1787246 1787656 R identified by similarity to SP:P77781; match to protein family HMM PF03061; match to protein family HMM TIGR00369; hypothetical protein complement(1787246..1787656) Escherichia coli HS 5591584 YP_001458470.1 CDS EcHS_A1768 NC_009800.1 1787653 1790709 R identified by match to protein family HMM PF01565; match to protein family HMM PF02913; oxidoreductase, FAD-binding complement(1787653..1790709) Escherichia coli HS 5591585 YP_001458471.1 CDS ydiK NC_009800.1 1791098 1792210 D YdiK; inner membrane protein; ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated; unknown function; inner membrane protein 1791098..1792210 Escherichia coli HS 5591586 YP_001458472.1 CDS EcHS_A1770 NC_009800.1 1792612 1792995 D identified by similarity to GB:AAZ88169.1; match to protein family HMM PF08965; hypothetical protein 1792612..1792995 Escherichia coli HS 5591530 YP_001458473.1 CDS ydiM NC_009800.1 1793128 1794309 D identified by match to protein family HMM PF07690; major facilitator family transporter 1793128..1794309 Escherichia coli HS 5591531 YP_001458474.1 CDS EcHS_A1772 NC_009800.1 1794530 1795801 D identified by match to protein family HMM PF07690; major facilitator transporter 1794530..1795801 Escherichia coli HS 5595049 YP_001458475.1 CDS EcHS_A1773 NC_009800.1 1795813 1796679 D YdiB; quinate/shikimate dehydrogenase from Escherichia coli uses both NAD and NAD(P) to convert quinate and shikimate to 3-dehydroquinate and 3-dehydroshikimate; quinate/shikimate dehydrogenase 1795813..1796679 Escherichia coli HS 5595050 YP_001458476.1 CDS aroD NC_009800.1 1796710 1797468 D catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase 1796710..1797468 Escherichia coli HS 5595051 YP_001458477.1 CDS EcHS_A1777 NC_009800.1 1799221 1800372 D may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain; acyl-CoA dehydrogenase 1799221..1800372 Escherichia coli HS 5591614 YP_001458478.1 CDS EcHS_A1779 NC_009800.1 1800686 1801189 R identified by match to protein family HMM PF03400; IS1, transposase orfB complement(1800686..1801189) Escherichia coli HS 5591468 YP_001458479.1 CDS EcHS_A1780 NC_009800.1 1801108 1801383 R identified by match to protein family HMM PF03811; IS1, transposase orfA complement(1801108..1801383) Escherichia coli HS 5591469 YP_001458480.1 CDS ppsA NC_009800.1 1801535 1803913 R catalyzes the formation of phosphoenolpyruvate from pyruvate; phosphoenolpyruvate synthase complement(1801535..1803913) Escherichia coli HS 5591470 YP_001458481.1 CDS EcHS_A1782 NC_009800.1 1803967 1804134 R identified by glimmer; hypothetical protein complement(1803967..1804134) Escherichia coli HS 5591624 YP_001458482.1 CDS EcHS_A1783 NC_009800.1 1804246 1805079 D ydiA; identified by similarity to SP:Q8ZDY4; match to protein family HMM PF03618; hypothetical protein 1804246..1805079 Escherichia coli HS 5591625 YP_001458483.1 CDS aroH NC_009800.1 1805236 1806282 D tryptophan sensitive; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate; phospho-2-dehydro-3-deoxyheptonate aldolase 1805236..1806282 Escherichia coli HS 5591626 YP_001458484.1 CDS EcHS_A1785 NC_009800.1 1806414 1806605 D ydiE; identified by similarity to GB:ABB66046.1; hypothetical protein 1806414..1806605 Escherichia coli HS 5591538 YP_001458485.1 CDS EcHS_A1786 NC_009800.1 1806609 1808045 R identified by similarity to SP:Q8Z6I8; match to protein family HMM PF02696; hypothetical protein complement(1806609..1808045) Escherichia coli HS 5591539 YP_001458486.1 CDS EcHS_A1787 NC_009800.1 1808108 1808821 R ydiV; identified by similarity to GB:ABB61913.1; hypothetical protein complement(1808108..1808821) Escherichia coli HS 5591540 YP_001458487.1 CDS EcHS_A1788 NC_009800.1 1809068 1809532 R identified by match to protein family HMM PF00877; NlpC/P60 family lipoprotein complement(1809068..1809532) Escherichia coli HS 5591656 YP_001458488.1 CDS btuD NC_009800.1 1809610 1810359 R ATP-binding protein that acts with the transmembrane protein BtuC and the solute binding protein BtuF to transport vitamin B12 into the cell; vitamin B12-transporter ATPase complement(1809610..1810359) Escherichia coli HS 5591657 YP_001458489.1 CDS btuE NC_009800.1 1810359 1810910 R similar to glutathione peroxidase; member of the btuCED operon which is required for vitamin B12 transport across the inner membrane; glutathione peroxidase complement(1810359..1810910) Escherichia coli HS 5591658 YP_001458490.1 CDS btuC NC_009800.1 1810973 1811953 R with BtuD and BtuF transports vitamin B12 into the cell; vtamin B12-transporter permease complement(1810973..1811953) Escherichia coli HS 5591505 YP_001458491.1 CDS ihfA NC_009800.1 1812054 1812353 R This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit alpha complement(1812054..1812353) Escherichia coli HS 5591506 YP_001458492.1 CDS pheT NC_009800.1 1812358 1814745 R catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta complement(1812358..1814745) Escherichia coli HS 5591507 YP_001458493.1 CDS pheS NC_009800.1 1814760 1815743 R catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha complement(1814760..1815743) Escherichia coli HS 5591242 YP_001458494.1 CDS EcHS_A1795 NC_009800.1 1815857 1815952 R identified by glimmer; hypothetical protein complement(1815857..1815952) Escherichia coli HS 5591243 YP_001458496.1 CDS rplT NC_009800.1 1816194 1816550 R binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 complement(1816194..1816550) Escherichia coli HS 5591523 YP_001458497.1 CDS rpmI NC_009800.1 1816603 1816800 R identified by match to protein family HMM PF01632; match to protein family HMM TIGR00001; 50S ribosomal protein L35 complement(1816603..1816800) Escherichia coli HS 5591524 YP_001458498.1 CDS infC NC_009800.1 1816897 1817331 R IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 complement(1816897..1817331) Escherichia coli HS 5591525 YP_001458499.1 CDS thrS NC_009800.1 1817443 1819371 R catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; threonyl-tRNA synthetase complement(1817443..1819371) Escherichia coli HS 5595060 YP_001458500.1 CDS EcHS_A1803 NC_009800.1 1822126 1822884 R identified by match to protein family HMM PF04338; hypothetical protein complement(1822126..1822884) Escherichia coli HS 5595062 YP_001458501.1 CDS pfkB NC_009800.1 1823171 1824100 D identified by similarity to SP:P06999; match to protein family HMM PF00294; match to protein family HMM TIGR03168; 6-phosphofructokinase 1823171..1824100 Escherichia coli HS 5595098 YP_001458502.1 CDS EcHS_A1805 NC_009800.1 1824201 1824491 D identified by similarity to SP:P64479; hypothetical protein 1824201..1824491 Escherichia coli HS 5595099 YP_001458503.1 CDS EcHS_A1806 NC_009800.1 1824597 1825457 D identified by match to protein family HMM PF01636; match to protein family HMM PF03881; fructosamine kinase 1824597..1825457 Escherichia coli HS 5595100 YP_001458504.1 CDS EcHS_A1807 NC_009800.1 1825498 1826034 R yniB; identified by similarity to GB:AAZ88138.1; hypothetical protein complement(1825498..1826034) Escherichia coli HS 5591941 YP_001458505.1 CDS EcHS_A1808 NC_009800.1 1826181 1826849 D YniC; catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate, mannose 6-phosphate and p-nitrophenyl phosphate; 2-deoxyglucose-6-phosphatase 1826181..1826849 Escherichia coli HS 5591942 YP_001458506.1 CDS EcHS_A1809 NC_009800.1 1827012 1827602 D ydjM; identified by match to protein family HMM PF04307; hypothetical protein 1827012..1827602 Escherichia coli HS 5591943 YP_001458507.1 CDS EcHS_A1810 NC_009800.1 1827735 1829126 D identified by match to protein family HMM PF00375; sodium/dicarboxylate symporter family protein 1827735..1829126 Escherichia coli HS 5595118 YP_001458508.1 CDS EcHS_A1811 NC_009800.1 1829130 1829933 R ydjO; identified by similarity to GB:AAN43089.1; hypothetical protein complement(1829130..1829933) Escherichia coli HS 5595119 YP_001458509.1 CDS cedA NC_009800.1 1830222 1830464 R identified by similarity to SP:P0AE60; cell division modulator complement(1830222..1830464) Escherichia coli HS 5595120 YP_001458510.1 CDS katE NC_009800.1 1830668 1832929 D Catalase HPII; monofunctional catalase that decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide; hydroperoxidase II 1830668..1832929 Escherichia coli HS 5592003 YP_001458511.1 CDS EcHS_A1814 NC_009800.1 1833165 1834145 R identified by match to protein family HMM PF01548; match to protein family HMM PF02371; IS621, transposase complement(1833165..1834145) Escherichia coli HS 5592004 YP_001458512.1 CDS EcHS_A1815 NC_009800.1 1834467 1835216 R identified by similarity to GB:BAB92994.1; match to protein family HMM PF04794; hypothetical protein complement(1834467..1835216) Escherichia coli HS 5592005 YP_001458513.1 CDS chbF NC_009800.1 1835229 1836581 R identified by similarity to SP:P17411; match to protein family HMM PF02056; 6-phospho-beta-glucosidase complement(1835229..1836581) Escherichia coli HS 5591490 YP_001458514.1 CDS chbR NC_009800.1 1836687 1837526 R represses the celABCDF-ydjC operon involved in carbon uptake; DNA-binding transcriptional regulator ChbR complement(1836687..1837526) Escherichia coli HS 5591491 YP_001458515.1 CDS chbC NC_009800.1 1837938 1839296 R catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; N,N'-diacetylchitobiose-specific PTS system transporter subunit IIC complement(1837938..1839296) Escherichia coli HS 5592104 YP_001458516.1 CDS chbB NC_009800.1 1839381 1839701 R catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; N,N'-diacetylchitobiose-specific PTS system transporter subunit IIB complement(1839381..1839701) Escherichia coli HS 5592105 YP_001458517.1 CDS osmE NC_009800.1 1840000 1840338 R osmotically-inducible lipoprotein E; activator of ntr-like gene protein; DNA-binding transcriptional activator OsmE complement(1840000..1840338) Escherichia coli HS 5592106 YP_001458518.1 CDS nadE NC_009800.1 1840540 1841367 D catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase 1840540..1841367 Escherichia coli HS 5591296 YP_001458519.1 CDS cho NC_009800.1 1841597 1842484 D 3' incision activity; acts with UvrC; nucleotide excision repair endonuclease 1841597..1842484 Escherichia coli HS 5591297 YP_001458520.1 CDS EcHS_A1824 NC_009800.1 1842444 1843019 R ydjR; identified by match to protein family HMM PF05962; hypothetical protein complement(1842444..1843019) Escherichia coli HS 5591298 YP_001458521.1 CDS spy NC_009800.1 1843222 1843707 R periplasmic protein induced by stress response via Cpx and BaeSR system; similar to CpxP; periplasmic protein complement(1843222..1843707) Escherichia coli HS 5591694 YP_001458522.1 CDS EcHS_A1826 NC_009800.1 1843842 1843943 D identified by glimmer; hypothetical protein 1843842..1843943 Escherichia coli HS 5591695 YP_001458523.1 CDS astE NC_009800.1 1844037 1845005 R catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism; succinylglutamate desuccinylase complement(1844037..1845005) Escherichia coli HS 5591696 YP_001458524.1 CDS astB NC_009800.1 1844998 1846341 R catalyzes the hydrolysis of 2-N-succinylarginine into 2-N-succinylornithine, ammonia and carbon dioxide in arginine degradation; succinylarginine dihydrolase complement(1844998..1846341) Escherichia coli HS 5591865 YP_001458525.1 CDS astD NC_009800.1 1846338 1847816 R a high throughput screen identified this enzyme as an aldehyde dehydrogenase with broad substrate specificity; converts succinylglutamate semialdehyde and NAD to succinylglutamate and NADH; succinylglutamic semialdehyde dehydrogenase complement(1846338..1847816) Escherichia coli HS 5591866 YP_001458526.1 CDS astA NC_009800.1 1847813 1848847 R identified by match to protein family HMM PF04958; match to protein family HMM TIGR03244; arginine succinyltransferase complement(1847813..1848847) Escherichia coli HS 5591867 YP_001458527.1 CDS astC NC_009800.1 1848844 1850064 R catalyzes the transamination of 2-N-succinylornithine and alpha-ketoglutarate into 2-N-succinylglutamate semialdehyde and glutamate; also functions as the catabolic acetylornithine aminotransferase catalyzing the formation of 2-N-acetylglutamate semialdehyde and glutamate from 2-N-acetylornithine and alpha-ketoglutarate; bifunctional succinylornithine transaminase/acetylornithine transaminase complement(1848844..1850064) Escherichia coli HS 5591270 YP_001458528.1 CDS EcHS_A1832 NC_009800.1 1850327 1850497 D identified by glimmer; hypothetical protein 1850327..1850497 Escherichia coli HS 5591271 YP_001458529.1 CDS xth NC_009800.1 1850510 1851316 D removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction; exonuclease III 1850510..1851316 Escherichia coli HS 5591272 YP_001458530.1 CDS EcHS_A1834 NC_009800.1 1851483 1852193 D identified by match to protein family HMM PF09335; hypothetical protein 1851483..1852193 Escherichia coli HS 5591659 YP_001458531.1 CDS EcHS_A1835 NC_009800.1 1852198 1852875 D ydjY; identified by similarity to GB:AAZ88114.1; hypothetical protein 1852198..1852875 Escherichia coli HS 5591660 YP_001458532.1 CDS EcHS_A1836 NC_009800.1 1852890 1853597 D ydjZ; identified by similarity to SP:P76221; match to protein family HMM PF09335; hypothetical protein 1852890..1853597 Escherichia coli HS 5591661 YP_001458533.1 CDS EcHS_A1837 NC_009800.1 1853597 1854145 D ynjA; identified by match to protein family HMM PF02627; carboxymuconolactone decarboxylase 1853597..1854145 Escherichia coli HS 5592128 YP_001458534.1 CDS EcHS_A1838 NC_009800.1 1854155 1855321 D ynjB; ABC transporter solute-binding protein 1854155..1855321 Escherichia coli HS 5592129 YP_001458535.1 CDS ynjC NC_009800.1 1855294 1856829 D ABC transporter permease 1855294..1856829 Escherichia coli HS 5592130 YP_001458536.1 CDS EcHS_A1840 NC_009800.1 1856829 1857482 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1856829..1857482 Escherichia coli HS 5592115 YP_001458537.1 CDS EcHS_A1841 NC_009800.1 1857549 1858856 D rhodanese-like domain-containing protein 1857549..1858856 Escherichia coli HS 5592116 YP_001458538.1 CDS EcHS_A1842 NC_009800.1 1858865 1859485 R identified by match to protein family HMM PF01066; CDP-alcohol phosphatidyltransferase complement(1858865..1859485) Escherichia coli HS 5592117 YP_001458539.1 CDS nudG NC_009800.1 1859572 1859979 D identified by similarity to SP:P77788; match to protein family HMM PF00293; pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase 1859572..1859979 Escherichia coli HS 5590994 YP_001458540.1 CDS EcHS_A1844 NC_009800.1 1859945 1860217 R ynjH; identified by match to protein family HMM PF07383; hypothetical protein complement(1859945..1860217) Escherichia coli HS 5590995 YP_001458541.1 CDS gdhA NC_009800.1 1860453 1861796 D converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 1860453..1861796 Escherichia coli HS 5590996 YP_001458542.1 CDS EcHS_A1846 NC_009800.1 1861913 1862953 R ynjI; identified by similarity to GB:AAN43058.1; hypothetical protein complement(1861913..1862953) Escherichia coli HS 5591030 YP_001458543.1 CDS topB NC_009800.1 1863081 1865042 R decatenates replicating daughter chromosomes; DNA topoisomerase III complement(1863081..1865042) Escherichia coli HS 5591031 YP_001458544.1 CDS selD NC_009800.1 1865047 1866090 R catalyzes the formation of selenophosphate from selenide and ATP; selenophosphate synthetase complement(1865047..1866090) Escherichia coli HS 5591032 YP_001458545.1 CDS EcHS_A1849 NC_009800.1 1866207 1866758 R ydjA; identified by match to protein family HMM PF00881; hypothetical protein complement(1866207..1866758) Escherichia coli HS 5591433 YP_001458546.1 CDS sppA NC_009800.1 1866919 1868775 D SppA; catalyzes the degradation of cleaved signal peptides; essential to maintain secretion of mature proteins across the membrane; protease 4 1866919..1868775 Escherichia coli HS 5591434 YP_001458547.1 CDS ansA NC_009800.1 1868942 1869958 D converts asparagine to aspartate and ammonia; cytoplasmic asparaginase I 1868942..1869958 Escherichia coli HS 5591435 YP_001458548.1 CDS pncA NC_009800.1 1869969 1870610 D catalyzes the formation of nicotinate from nicotinamide in NAD biosynthesis and the formation of pyrazinoate from pyrazinamide; nicotinamidase/pyrazinamidase 1869969..1870610 Escherichia coli HS 5591083 YP_001458549.1 CDS ydjE NC_009800.1 1870703 1872061 R identified by match to protein family HMM PF00083; match to protein family HMM PF07690; major facilitator family transporter complement(1870703..1872061) Escherichia coli HS 5591084 YP_001458550.1 CDS EcHS_A1854 NC_009800.1 1872179 1872937 R identified by match to protein family HMM PF00455; match to protein family HMM PF08220; match to protein family HMM PF08279; DeoR family transcriptional regulator complement(1872179..1872937) Escherichia coli HS 5591085 YP_001458551.1 CDS EcHS_A1855 NC_009800.1 1873074 1874054 R identified by match to protein family HMM PF00248; aldo/keto reductase complement(1873074..1874054) Escherichia coli HS 5590887 YP_001458552.1 CDS EcHS_A1856 NC_009800.1 1874064 1875011 R identified by match to protein family HMM PF00294; PfkB family kinase complement(1874064..1875011) Escherichia coli HS 5590888 YP_001458553.1 CDS EcHS_A1857 NC_009800.1 1875016 1875852 R identified by match to protein family HMM PF01116; match to protein family HMM TIGR00167; fructose-bisphosphate aldolase complement(1875016..1875852) Escherichia coli HS 5590889 YP_001458554.1 CDS ydjK NC_009800.1 1876827 1878206 R identified by match to protein family HMM PF00083; match to protein family HMM PF07690; major facilitator family transporter complement(1876827..1878206) Escherichia coli HS 5590956 YP_001458555.1 CDS EcHS_A1861 NC_009800.1 1878233 1879309 R identified by match to protein family HMM PF00107; match to protein family HMM PF08240; zinc-binding dehydrogenase oxidoreductase complement(1878233..1879309) Escherichia coli HS 5590957 YP_001458556.1 CDS EcHS_A1862 NC_009800.1 1879679 1879951 R NULL; identified by match to protein family HMM PF07023; hypothetical protein complement(1879679..1879951) Escherichia coli HS 5591074 YP_001458557.1 CDS msrB NC_009800.1 1879993 1880406 R this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress; methionine sulfoxide reductase B complement(1879993..1880406) Escherichia coli HS 5591075 YP_001458558.1 CDS gapA NC_009800.1 1880748 1881743 D identified by similarity to SP:P0A9B2; match to protein family HMM PF00044; match to protein family HMM PF02800; match to protein family HMM TIGR01534; glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 1880748..1881743 Escherichia coli HS 5591076 YP_001458559.1 CDS EcHS_A1865 NC_009800.1 1881806 1882711 D yeaD; identified by match to protein family HMM PF01263; aldose 1-epimerase 1881806..1882711 Escherichia coli HS 5590929 YP_001458560.1 CDS EcHS_A1866 NC_009800.1 1882759 1883613 R identified by similarity to SP:P76234; match to protein family HMM PF00248; aldo/keto reductase complement(1882759..1883613) Escherichia coli HS 5590930 YP_001458561.1 CDS mipA NC_009800.1 1883703 1884449 R yeaF; identified by similarity to SP:P0A908; match to protein family HMM PF06629; MltA-interacting protein MipA complement(1883703..1884449) Escherichia coli HS 5590931 YP_001458562.1 CDS EcHS_A1868 NC_009800.1 1884569 1884670 D identified by glimmer; hypothetical protein 1884569..1884670 Escherichia coli HS 5590997 YP_001458563.1 CDS EcHS_A1869 NC_009800.1 1884885 1886819 D yeaG; identified by match to protein family HMM PF06798; match to protein family HMM PF08298; serine kinase 1884885..1886819 Escherichia coli HS 5590998 YP_001458564.1 CDS EcHS_A1870 NC_009800.1 1886932 1888215 D yeaH; identified by match to protein family HMM PF04285; hypothetical protein 1886932..1888215 Escherichia coli HS 5590999 YP_001458565.1 CDS EcHS_A1871 NC_009800.1 1888362 1889837 D yeaI; identified by match to protein family HMM PF00990; match to protein family HMM TIGR00254; diguanylate cyclase 1888362..1889837 Escherichia coli HS 5591173 YP_001458566.1 CDS EcHS_A1872 NC_009800.1 1890018 1891508 D identified by match to protein family HMM PF00990; match to protein family HMM TIGR00254; diguanylate cyclase 1890018..1891508 Escherichia coli HS 5591174 YP_001458567.1 CDS EcHS_A1873 NC_009800.1 1891551 1892054 D identified by match to protein family HMM PF04073; prolyl-tRNA synthetase 1891551..1892054 Escherichia coli HS 5591175 YP_001458568.1 CDS EcHS_A1874 NC_009800.1 1892055 1892207 R identified by similarity to GB:AAZ88084.1; hypothetical protein complement(1892055..1892207) Escherichia coli HS 5590942 YP_001458569.1 CDS EcHS_A1875 NC_009800.1 1892329 1892775 D yeaL; identified by similarity to SP:P0ACY8; match to protein family HMM PF04284; hypothetical protein 1892329..1892775 Escherichia coli HS 5590943 YP_001458570.1 CDS EcHS_A1876 NC_009800.1 1892732 1893553 R identified by match to protein family HMM PF00165; AraC family transcriptional regulator complement(1892732..1893553) Escherichia coli HS 5590944 YP_001458571.1 CDS yeaN NC_009800.1 1893650 1894831 D identified by similarity to SP:P76242; match to protein family HMM PF07690; match to protein family HMM TIGR00896; inner membrane transport protein yeaN 1893650..1894831 Escherichia coli HS 5590973 YP_001458572.1 CDS EcHS_A1878 NC_009800.1 1894886 1895233 D yeaO; identified by match to protein family HMM PF04343; hypothetical protein 1894886..1895233 Escherichia coli HS 5590974 YP_001458573.1 CDS EcHS_A1879 NC_009800.1 1895255 1895509 R yoaF; identified by match to protein family HMM PF03891; lipoprotein complement(1895255..1895509) Escherichia coli HS 5590975 YP_001458574.1 CDS EcHS_A1880 NC_009800.1 1895563 1896717 D identified by match to protein family HMM PF00990; match to protein family HMM PF01590; match to protein family HMM TIGR00254; GAF domain/diguanylate cyclase domain-containing protein 1895563..1896717 Escherichia coli HS 5591055 YP_001458575.1 CDS EcHS_A1881 NC_009800.1 1896735 1896848 D identified by glimmer; hypothetical protein 1896735..1896848 Escherichia coli HS 5591056 YP_001458576.1 CDS EcHS_A1882 NC_009800.1 1896984 1897232 R identified by match to protein family HMM PF04226; hypothetical protein complement(1896984..1897232) Escherichia coli HS 5591057 YP_001458577.1 CDS EcHS_A1883 NC_009800.1 1897244 1897366 R identified by glimmer; hypothetical protein complement(1897244..1897366) Escherichia coli HS 5591100 YP_001458578.1 CDS EcHS_A1884 NC_009800.1 1897380 1897562 R yoaG; identified by similarity to GB:CAG74382.1; match to protein family HMM PF08956; hypothetical protein complement(1897380..1897562) Escherichia coli HS 5591101 YP_001458579.1 CDS EcHS_A1885 NC_009800.1 1897566 1897925 R yeaR; identified by match to protein family HMM PF09313; hypothetical protein complement(1897566..1897925) Escherichia coli HS 5591102 YP_001458580.1 CDS EcHS_A1886 NC_009800.1 1898098 1898736 R yeaS; identified by match to protein family HMM PF01810; leucine export protein LeuE complement(1898098..1898736) Escherichia coli HS 5590900 YP_001458581.1 CDS EcHS_A1887 NC_009800.1 1898863 1899786 R identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator complement(1898863..1899786) Escherichia coli HS 5590901 YP_001458582.1 CDS ttuC NC_009800.1 1899889 1900974 D identified by similarity to SP:Q51945; match to protein family HMM PF00180; match to protein family HMM TIGR02089; tartrate dehydrogenase/decarboxylase 1899889..1900974 Escherichia coli HS 5590902 YP_001458583.1 CDS EcHS_A1889 NC_009800.1 1901225 1902835 D member of the betaine, carnitine, choline transporter (BCCT) family; unknown function; transporter 1901225..1902835 Escherichia coli HS 5592421 YP_001458584.1 CDS EcHS_A1890 NC_009800.1 1902867 1903991 D identified by match to protein family HMM PF00355; Rieske (2Fe-2S) domain-containing protein 1902867..1903991 Escherichia coli HS 5592422 YP_001458585.1 CDS EcHS_A1891 NC_009800.1 1904047 1905012 D identified by match to protein family HMM PF00111; match to protein family HMM PF00175; match to protein family HMM PF00970; oxidoreductase, FAD/NAD-binding/iron-sulfur cluster binding protein 1904047..1905012 Escherichia coli HS 5592423 YP_001458586.1 CDS rnd NC_009800.1 1905066 1906193 R identified by match to protein family HMM PF00570; match to protein family HMM PF01612; match to protein family HMM TIGR01388; ribonuclease D complement(1905066..1906193) Escherichia coli HS 5590979 YP_001458587.1 CDS fadD NC_009800.1 1906263 1907948 R Activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase complement(1906263..1907948) Escherichia coli HS 5590981 YP_001458588.1 CDS slp NC_009800.1 1908153 1908734 R identified by similarity to SP:P37194; match to protein family HMM PF03843; match to protein family HMM TIGR00752; outer membrane protein Slp complement(1908153..1908734) Escherichia coli HS 5592331 YP_001458589.1 CDS EcHS_A1895 NC_009800.1 1908774 1909469 R yeaZ; identified by match to protein family HMM PF00814; glycoprotease complement(1908774..1909469) Escherichia coli HS 5592332 YP_001458590.1 CDS EcHS_A1896 NC_009800.1 1909527 1911437 R hypothetical protein complement(1909527..1911437) Escherichia coli HS 5592333 YP_001458591.1 CDS EcHS_A1897 NC_009800.1 1911569 1911913 D identified by match to protein family HMM PF01042; endoribonuclease L-PSP 1911569..1911913 Escherichia coli HS 5592470 YP_001458592.1 CDS EcHS_A1898 NC_009800.1 1912275 1912577 D identified by similarity to SP:P64492; match to protein family HMM PF08986; hypothetical protein 1912275..1912577 Escherichia coli HS 5592471 YP_001458593.1 CDS EcHS_A1899 NC_009800.1 1912628 1912903 D identified by match to protein family HMM PF03811; IS1, transposase orfA 1912628..1912903 Escherichia coli HS 5592472 YP_001458594.1 CDS EcHS_A1900 NC_009800.1 1912822 1913325 D identified by match to protein family HMM PF03400; IS1, transposase orfB 1912822..1913325 Escherichia coli HS 5592477 YP_001458595.1 CDS EcHS_A1901 NC_009800.1 1913528 1913692 D identified by glimmer; hypothetical protein 1913528..1913692 Escherichia coli HS 5592478 YP_001458596.1 CDS pabB NC_009800.1 1913784 1915145 D identified by similarity to SP:P05041; match to protein family HMM PF00425; match to protein family HMM PF04715; match to protein family HMM TIGR00553; para-aminobenzoate synthase component I 1913784..1915145 Escherichia coli HS 5592479 YP_001458597.1 CDS EcHS_A1903 NC_009800.1 1915149 1915727 D identified by match to protein family HMM PF00293; hypothetical protein 1915149..1915727 Escherichia coli HS 5591310 YP_001458598.1 CDS sdaA2 NC_009800.1 1915911 1917275 D identified by similarity to SP:P16095; match to protein family HMM PF03313; match to protein family HMM PF03315; match to protein family HMM TIGR00720; L-serine dehydratase 1 1915911..1917275 Escherichia coli HS 5591311 YP_001458599.1 CDS EcHS_A1905 NC_009800.1 1917406 1919004 D identified by match to protein family HMM PF00563; cyclic diguanylate phosphodiesterase domain-containing protein 1917406..1919004 Escherichia coli HS 5591312 YP_001458600.1 CDS EcHS_A1906 NC_009800.1 1919008 1920564 R identified by match to protein family HMM PF00571; match to protein family HMM PF03471; match to protein family HMM PF03741; TerC family/CBS/transporter associated domain-containing protein complement(1919008..1920564) Escherichia coli HS 5592534 YP_001458601.1 CDS manX NC_009800.1 1921027 1921998 D identified by match to protein family HMM PF03610; match to protein family HMM PF03830; match to protein family HMM TIGR00824; match to protein family HMM TIGR00854; PTS system, mannose-specific IIAB component 1921027..1921998 Escherichia coli HS 5592535 YP_001458602.1 CDS manY NC_009800.1 1922061 1922861 D identified by match to protein family HMM PF03609; match to protein family HMM TIGR00822; PTS system, mannose-specific IIC component 1922061..1922861 Escherichia coli HS 5592536 YP_001458603.1 CDS manZ NC_009800.1 1922874 1923725 D hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel; mannose-specific PTS system protein IID 1922874..1923725 Escherichia coli HS 5592625 YP_001458604.1 CDS EcHS_A1910 NC_009800.1 1923780 1924238 D identified by similarity to SP:Q8ZP01; match to protein family HMM PF06173; hypothetical protein 1923780..1924238 Escherichia coli HS 5592626 YP_001458605.1 CDS EcHS_A1911 NC_009800.1 1924667 1925233 D membrane protein YebN; hypothetical protein 1924667..1925233 Escherichia coli HS 5592627 YP_001458606.1 CDS rrmA NC_009800.1 1925230 1926039 R methylates the guanosine in position 745 of 23S rRNA; required for translation and cell growth; 23S rRNA methyltransferase complement(1925230..1926039) Escherichia coli HS 5592622 YP_001458607.1 CDS cspC NC_009800.1 1926205 1926414 R identified by similarity to SP:P0A9Y6; match to protein family HMM PF00313; cold shock-like protein CspC complement(1926205..1926414) Escherichia coli HS 5592623 YP_001458608.1 CDS EcHS_A1914 NC_009800.1 1926427 1926570 R identified by similarity to SP:P64511; hypothetical protein complement(1926427..1926570) Escherichia coli HS 5592624 YP_001458609.1 CDS EcHS_A1915 NC_009800.1 1927239 1927526 R identified by similarity to SP:P64499; hypothetical protein complement(1927239..1927526) Escherichia coli HS 5595146 YP_001458610.1 CDS EcHS_A1916 NC_009800.1 1927601 1927744 R hypothetical protein complement(1927601..1927744) Escherichia coli HS 5595147 YP_001458611.1 CDS EcHS_A1917 NC_009800.1 1927903 1928142 D NULL; identified by similarity to GB:ABB62074.1; hypothetical protein 1927903..1928142 Escherichia coli HS 5595148 YP_001458612.1 CDS kdgR NC_009800.1 1928285 1929076 R identified by similarity to SP:P76268; match to protein family HMM PF01614; match to protein family HMM PF09339; transcriptional regulator KdgR complement(1928285..1929076) Escherichia coli HS 5595127 YP_001458613.1 CDS EcHS_A1919 NC_009800.1 1929253 1930626 D identified by match to protein family HMM PF07690; major facilitator transporter 1929253..1930626 Escherichia coli HS 5595128 YP_001458614.1 CDS EcHS_A1920 NC_009800.1 1930672 1931553 R metalloprotease; heat shock protein HtpX complement(1930672..1931553) Escherichia coli HS 5595129 YP_001458615.1 CDS prc NC_009800.1 1931745 1933793 R Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3; carboxy-terminal protease complement(1931745..1933793) Escherichia coli HS 5592467 YP_001458616.1 CDS proQ NC_009800.1 1933813 1934511 R affects solute and DNA transport through an unknown mechanism; solute/DNA competence effector complement(1933813..1934511) Escherichia coli HS 5592468 YP_001458617.1 CDS EcHS_A1923 NC_009800.1 1934608 1935159 R identified by match to protein family HMM PF01590; GAF domain-containing protein complement(1934608..1935159) Escherichia coli HS 5592469 YP_001458618.1 CDS EcHS_A1924 NC_009800.1 1935235 1936518 D identified by match to protein family HMM PF04403; match to protein family HMM TIGR00155; PqiA family integral membrane protein 1935235..1936518 Escherichia coli HS 5592628 YP_001458619.1 CDS EcHS_A1925 NC_009800.1 1936481 1939120 D identified by similarity to SP:P76272; match to protein family HMM PF02470; mce-related protein 1936481..1939120 Escherichia coli HS 5592629 YP_001458620.1 CDS yebU NC_009800.1 1939194 1940639 D in Escherichia coli this enzyme specifically methylates C1407 of the 16S rRNA; rRNA (cytosine-C(5)-)-methyltransferase RsmF 1939194..1940639 Escherichia coli HS 5592630 YP_001458621.1 CDS EcHS_A1927 NC_009800.1 1940757 1940993 D identified by match to protein family HMM PF07351; hypothetical protein 1940757..1940993 Escherichia coli HS 5592767 YP_001458622.1 CDS EcHS_A1928 NC_009800.1 1941014 1941289 D identified by match to protein family HMM PF07358; hypothetical protein 1941014..1941289 Escherichia coli HS 5592768 YP_001458623.1 CDS pphA NC_009800.1 1941290 1941946 R Plays a key role in signaling protein misfolding via the cpxR/cpxA transducing system; modulates the phosphorylated status of many phosphoproteins; serine/threonine protein phosphatase 1 complement(1941290..1941946) Escherichia coli HS 5592769 YP_001458624.1 CDS EcHS_A1930 NC_009800.1 1942342 1942683 R identified by similarity to GB:ABB61282.1; hypothetical protein complement(1942342..1942683) Escherichia coli HS 5595087 YP_001458625.1 CDS EcHS_A1931 NC_009800.1 1942696 1943568 R identified by match to protein family HMM PF05425; copper resistance protein D complement(1942696..1943568) Escherichia coli HS 5595168 YP_001458626.1 CDS EcHS_A1932 NC_009800.1 1943572 1943946 R identified by match to protein family HMM PF04234; hypothetical protein complement(1943572..1943946) Escherichia coli HS 5595169 YP_001458627.1 CDS holE NC_009800.1 1944085 1944315 D identified by similarity to SP:P0ABT1; match to protein family HMM PF06440; DNA polymerase III subunit theta 1944085..1944315 Escherichia coli HS 5595170 YP_001458628.1 CDS EcHS_A1934 NC_009800.1 1944417 1945073 D NULL; identified by match to protein family HMM PF00795; carbon-nitrogen family hydrolase 1944417..1945073 Escherichia coli HS 5592881 YP_001458629.1 CDS exoX NC_009800.1 1945097 1945759 D 3'-5' exonuclease activity on single or double-strand DNA; exodeoxyribonuclease X 1945097..1945759 Escherichia coli HS 5592882 YP_001458630.1 CDS prtB NC_009800.1 1945756 1947816 R PtrB; oligopeptidase that cleaves peptide bonds following arginine and lysine residues; protease 2 complement(1945756..1947816) Escherichia coli HS 5592883 YP_001458631.1 CDS EcHS_A1937 NC_009800.1 1947902 1948504 D identified by similarity to GB:AAN80716.1; hypothetical protein 1947902..1948504 Escherichia coli HS 5595453 YP_001458632.1 CDS EcHS_A1938 NC_009800.1 1948744 1948854 D identified by glimmer; hypothetical protein 1948744..1948854 Escherichia coli HS 5595454 YP_001458633.1 CDS EcHS_A1939 NC_009800.1 1949011 1949367 R secreted protein; unknown function; hypothetical protein complement(1949011..1949367) Escherichia coli HS 5595455 YP_001458634.1 CDS EcHS_A1940 NC_009800.1 1949434 1949724 R identified by similarity to SP:P0ACY9; match to protein family HMM PF07130; DNA damage-inducible protein YebG complement(1949434..1949724) Escherichia coli HS 5595002 YP_001458635.1 CDS purT NC_009800.1 1949858 1951036 D non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis; phosphoribosylglycinamide formyltransferase 2 1949858..1951036 Escherichia coli HS 5595003 YP_001458636.1 CDS eda NC_009800.1 1951092 1951733 R catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase complement(1951092..1951733) Escherichia coli HS 5595004 YP_001458637.1 CDS edd NC_009800.1 1951770 1953581 R catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate; phosphogluconate dehydratase complement(1951770..1953581) Escherichia coli HS 5594033 YP_001458638.1 CDS zwf NC_009800.1 1953816 1955291 R catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase complement(1953816..1955291) Escherichia coli HS 5594034 YP_001458639.1 CDS EcHS_A1945 NC_009800.1 1955457 1955606 R identified by similarity to GB:AAN80723.1; hypothetical protein complement(1955457..1955606) Escherichia coli HS 5594035 YP_001458640.1 CDS EcHS_A1946 NC_009800.1 1955629 1956498 D Represses the expression of the zwf, eda, glp and gap; DNA-binding transcriptional regulator HexR 1955629..1956498 Escherichia coli HS 5592953 YP_001458641.1 CDS pykA NC_009800.1 1956626 1958068 D catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1956626..1958068 Escherichia coli HS 5592954 YP_001458642.1 CDS msbB NC_009800.1 1958199 1959170 R Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase complement(1958199..1959170) Escherichia coli HS 5592955 YP_001458643.1 CDS EcHS_A1949 NC_009800.1 1959290 1960612 R yebA; identified by match to protein family HMM PF01476; match to protein family HMM PF01551; match to protein family HMM PF04225; match to protein family HMM PF08525; hypothetical protein complement(1959290..1960612) Escherichia coli HS 5593781 YP_001458644.1 CDS znuA NC_009800.1 1960628 1961560 R involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter periplasmic component complement(1960628..1961560) Escherichia coli HS 5593782 YP_001458645.1 CDS znuC NC_009800.1 1961639 1962394 D involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter ATPase 1961639..1962394 Escherichia coli HS 5593783 YP_001458646.1 CDS znuB NC_009800.1 1962391 1963176 D involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter membrane component 1962391..1963176 Escherichia coli HS 5595462 YP_001458647.1 CDS ruvB NC_009800.1 1963517 1964527 R promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB complement(1963517..1964527) Escherichia coli HS 5595463 YP_001458648.1 CDS ruvA NC_009800.1 1964536 1965147 R plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA complement(1964536..1965147) Escherichia coli HS 5595464 YP_001458649.1 CDS EcHS_A1955 NC_009800.1 1965323 1966024 D yebB; identified by match to protein family HMM PF06520; hypothetical protein 1965323..1966024 Escherichia coli HS 5594908 YP_001458650.1 CDS ruvC NC_009800.1 1966026 1966547 R endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase complement(1966026..1966547) Escherichia coli HS 5594909 YP_001458651.1 CDS EcHS_A1957 NC_009800.1 1966582 1967322 R yebC; identified by match to protein family HMM PF01709; match to protein family HMM TIGR01033; hypothetical protein complement(1966582..1967322) Escherichia coli HS 5594910 YP_001458652.1 CDS ntpA NC_009800.1 1967351 1967803 R converts dATP to dAMP and pyrophosphate; dATP pyrophosphohydrolase complement(1967351..1967803) Escherichia coli HS 5595175 YP_001458653.1 CDS aspS NC_009800.1 1967921 1969693 R catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase complement(1967921..1969693) Escherichia coli HS 5595176 YP_001458654.1 CDS EcHS_A1960 NC_009800.1 1969883 1969978 R identified by glimmer; hypothetical protein complement(1969883..1969978) Escherichia coli HS 5595177 YP_001458655.1 CDS EcHS_A1961 NC_009800.1 1970003 1970569 D yecD; identified by match to protein family HMM PF00857; hypothetical protein 1970003..1970569 Escherichia coli HS 5592371 YP_001458656.1 CDS EcHS_A1962 NC_009800.1 1970566 1971384 D identified by similarity to SP:P37348; match to protein family HMM PF01904; hypothetical protein 1970566..1971384 Escherichia coli HS 5592372 YP_001458657.1 CDS EcHS_A1963 NC_009800.1 1971437 1971832 D yecN; identified by similarity to SP:P64515; inner membrane protein 1971437..1971832 Escherichia coli HS 5592373 YP_001458658.1 CDS EcHS_A1964 NC_009800.1 1971873 1972616 D yecO; identified by match to protein family HMM PF08241; match to protein family HMM PF08242; match to protein family HMM TIGR00740; methyltransferase 1971873..1972616 Escherichia coli HS 5592538 YP_001458659.1 CDS EcHS_A1965 NC_009800.1 1972613 1973584 D identified by match to protein family HMM PF08003; match to protein family HMM PF08241; match to protein family HMM TIGR00452; methyltransferase 1972613..1973584 Escherichia coli HS 5592539 YP_001458660.1 CDS EcHS_A1966 NC_009800.1 1973612 1973758 D identified by glimmer; hypothetical protein 1973612..1973758 Escherichia coli HS 5592540 YP_001458661.1 CDS torZ NC_009800.1 1973749 1976196 R identified by similarity to SP:P46923; match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM TIGR00509; match to protein family HMM TIGR01409; trimethylamine N-oxide reductase III, subunit TorZ complement(1973749..1976196) Escherichia coli HS 5593003 YP_001458662.1 CDS torY NC_009800.1 1976203 1977303 R identified by similarity to SP:P52005; match to protein family HMM PF03264; trimethylamine N-oxide reductase III, c-type cytochrome subunit TorY complement(1976203..1977303) Escherichia coli HS 5593004 YP_001458663.1 CDS cutC NC_009800.1 1977691 1978437 R identified by similarity to SP:P67825; match to protein family HMM PF03932; copper homeostasis protein CutC complement(1977691..1978437) Escherichia coli HS 5593005 YP_001458664.1 CDS EcHS_A1970 NC_009800.1 1978451 1979023 R yecM; identified by similarity to GB:AAL20824.1; match to protein family HMM PF06185; hypothetical protein complement(1978451..1979023) Escherichia coli HS 5592841 YP_001458665.1 CDS argS NC_009800.1 1979233 1980966 D catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1979233..1980966 Escherichia coli HS 5592842 YP_001458666.1 CDS EcHS_A1972 NC_009800.1 1981143 1981631 D yecT; identified by match to protein family HMM PF07007; hypothetical protein 1981143..1981631 Escherichia coli HS 5592843 YP_001458667.1 CDS flhE NC_009800.1 1981751 1982143 R identified by similarity to SP:P76297; match to protein family HMM PF06366; flagellar protein FlhE complement(1981751..1982143) Escherichia coli HS 5592700 YP_001458668.1 CDS flhA NC_009800.1 1982143 1984221 R membrane protein involved in the flagellar export apparatus; flagellar biosynthesis protein FlhA complement(1982143..1984221) Escherichia coli HS 5592701 YP_001458669.1 CDS flhB NC_009800.1 1984214 1985362 R membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export; flagellar biosynthesis protein FlhB complement(1984214..1985362) Escherichia coli HS 5592702 YP_001458670.1 CDS EcHS_A1976 NC_009800.1 1985395 1985529 D identified by glimmer; hypothetical protein 1985395..1985529 Escherichia coli HS 5595053 YP_001458671.1 CDS cheZ NC_009800.1 1985564 1986208 R cytosolic phosphatase which functions in the chemotaxis signal transduction complex by controlling the level of phosphorylated CheY through dephosphorylation; chemotaxis regulator CheZ complement(1985564..1986208) Escherichia coli HS 5595054 YP_001458672.1 CDS cheY NC_009800.1 1986219 1986608 R chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble; chemotaxis regulatory protein CheY complement(1986219..1986608) Escherichia coli HS 5595055 YP_001458673.1 CDS cheB NC_009800.1 1986623 1987672 R regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins; chemotaxis-specific methylesterase complement(1986623..1987672) Escherichia coli HS 5593173 YP_001458674.1 CDS cheR NC_009800.1 1987675 1988535 R methylates the MCP; chemotaxis methyltransferase CheR complement(1987675..1988535) Escherichia coli HS 5593174 YP_001458675.1 CDS tap NC_009800.1 1988554 1990155 R mediates taxis toward dipeptides; methyl-accepting protein IV complement(1988554..1990155) Escherichia coli HS 5593175 YP_001458676.1 CDS tar NC_009800.1 1990201 1991862 R identified by similarity to SP:P07017; match to protein family HMM PF00015; match to protein family HMM PF00672; match to protein family HMM PF02203; methyl-accepting chemotaxis protein II complement(1990201..1991862) Escherichia coli HS 5593453 YP_001458677.1 CDS cheW NC_009800.1 1992007 1992510 R identified by similarity to SP:P0A964; match to protein family HMM PF01584; purine-binding chemotaxis protein complement(1992007..1992510) Escherichia coli HS 5593455 YP_001458678.1 CDS cheA NC_009800.1 1992531 1994495 R chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY; sensory histidine kinase/signal sensing protein; CheA is the histidine kinase component; chemotaxis protein CheA complement(1992531..1994495) Escherichia coli HS 5593420 YP_001458679.1 CDS motB NC_009800.1 1994500 1995426 R with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotB complement(1994500..1995426) Escherichia coli HS 5593421 YP_001458680.1 CDS motA NC_009800.1 1995423 1996310 R With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotA complement(1995423..1996310) Escherichia coli HS 5593422 YP_001458681.1 CDS flhC NC_009800.1 1996437 1997015 R With FlhD is involved in the activation of class 2 flagellar genes and as well as a number of other genetic systems; transcriptional activator FlhC complement(1996437..1997015) Escherichia coli HS 5592570 YP_001458682.1 CDS flhD NC_009800.1 1997018 1997368 R with FlhC is involved in the activation of class 2 flagellar genes and is involved in the regulation of a number of other genetic systems; transcriptional activator FlhD complement(1997018..1997368) Escherichia coli HS 5592571 YP_001458683.1 CDS EcHS_A1989 NC_009800.1 1997399 1997497 R identified by glimmer; hypothetical protein complement(1997399..1997497) Escherichia coli HS 5592572 YP_001458684.1 CDS EcHS_A1990 NC_009800.1 1998114 1998392 D identified by match to protein family HMM PF01527; ISEhe3, transposase orfA 1998114..1998392 Escherichia coli HS 5592808 YP_001458685.1 CDS EcHS_A1991 NC_009800.1 1998449 1999261 D identified by similarity to GB:AAP17067.1; match to protein family HMM PF00665; ISEhe3, transposase orfB 1998449..1999261 Escherichia coli HS 5592809 YP_001458686.1 CDS uspC NC_009800.1 1999380 1999808 D ppGpp-dependent; membrane-associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress; universal stress protein UspC 1999380..1999808 Escherichia coli HS 5592810 YP_001458687.1 CDS otsA NC_009800.1 1999815 2001239 R identified by match to protein family HMM PF00982; match to protein family HMM TIGR02400; trehalose-6-phosphate synthase complement(1999815..2001239) Escherichia coli HS 5592242 YP_001458688.1 CDS otsB NC_009800.1 2001214 2002014 R biosynthetic; catalyzes the formation of trehalose and phosphate from trehalose-6-phosphate; expression is increased under osmotic stress and induced during the transition to stationary phase and by decreased temperature; trehalose-6-phosphate phosphatase complement(2001214..2002014) Escherichia coli HS 5592243 YP_001458689.1 CDS araH NC_009800.1 2002181 2003167 R Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose transporter permease complement(2002181..2003167) Escherichia coli HS 5592244 YP_001458690.1 CDS araG NC_009800.1 2003182 2004696 R Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose transporter ATP-binding protein complement(2003182..2004696) Escherichia coli HS 5595247 YP_001458691.1 CDS araF NC_009800.1 2004766 2005755 R identified by match to protein family HMM PF00532; L-arabinose ABC transporter periplasmic L-arabinose-binding protein complement(2004766..2005755) Escherichia coli HS 5595248 YP_001458692.1 CDS EcHS_A1998 NC_009800.1 2006552 2007055 D identified by match to protein family HMM PF00210; ferritin 2006552..2007055 Escherichia coli HS 5595249 YP_001458694.1 CDS EcHS_A2000 NC_009800.1 2007497 2007643 D identified by glimmer; hypothetical protein 2007497..2007643 Escherichia coli HS 5592835 YP_001458695.1 CDS EcHS_A2001 NC_009800.1 2007849 2008172 D yecR; lipoprotein 2007849..2008172 Escherichia coli HS 5592836 YP_001458696.1 CDS EcHS_A2002 NC_009800.1 2008178 2008318 R identified by glimmer; hypothetical protein complement(2008178..2008318) Escherichia coli HS 5592011 YP_001458697.1 CDS ftnA NC_009800.1 2008343 2008840 D cytoplasmic iron storage protein; ferritin 2008343..2008840 Escherichia coli HS 5592012 YP_001458698.1 CDS EcHS_A2004 NC_009800.1 2008878 2009117 R yecH; identified by similarity to SP:P46887; hypothetical protein complement(2008878..2009117) Escherichia coli HS 5592013 YP_001458699.1 CDS tyrP NC_009800.1 2009308 2010519 D identified by match to protein family HMM PF01490; match to protein family HMM PF03222; match to protein family HMM TIGR00837; tyrosine-specific transport protein 2009308..2010519 Escherichia coli HS 5593524 YP_001458700.1 CDS EcHS_A2006 NC_009800.1 2010581 2011246 R yecA; identified by match to protein family HMM PF02810; match to protein family HMM TIGR02292; hypothetical protein complement(2010581..2011246) Escherichia coli HS 5593525 YP_001458701.1 CDS pgsA NC_009800.1 2011896 2012444 R identified by match to protein family HMM PF01066; match to protein family HMM TIGR00560; phosphatidylglycerophosphate synthetase complement(2011896..2012444) Escherichia coli HS 5592533 YP_001458702.1 CDS uvrC NC_009800.1 2012501 2014333 R The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C complement(2012501..2014333) Escherichia coli HS 5593577 YP_001458703.1 CDS uvrY NC_009800.1 2014330 2014986 R in Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system; in Salmonella SirA and BarA regulate virulence gene expression also via the Csr system; response regulator complement(2014330..2014986) Escherichia coli HS 5593578 YP_001458704.1 CDS EcHS_A2013 NC_009800.1 2015225 2015353 R hypothetical protein complement(2015225..2015353) Escherichia coli HS 5593579 YP_001458705.1 CDS EcHS_A2014 NC_009800.1 2015445 2015669 D yecF; identified by similarity to SP:P0AD09; hypothetical protein 2015445..2015669 Escherichia coli HS 5593366 YP_001458706.1 CDS sdiA NC_009800.1 2015737 2016459 R regulates genes involved in cell division; DNA-binding transcriptional activator SdiA complement(2015737..2016459) Escherichia coli HS 5593367 YP_001458707.1 CDS yecC NC_009800.1 2016689 2017441 R identified by match to protein family HMM PF00005; amino-acid ABC transporter ATP-binding protein YecC complement(2016689..2017441) Escherichia coli HS 5593368 YP_001458708.1 CDS EcHS_A2017 NC_009800.1 2017438 2018106 R identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; L-cystine ABC transporter permease complement(2017438..2018106) Escherichia coli HS 5593827 YP_001458709.1 CDS dcyD NC_009800.1 2018121 2019107 R catalyzes the formation of pyruvate from D-cysteine; D-cysteine desulfhydrase complement(2018121..2019107) Escherichia coli HS 5593828 YP_001458710.1 CDS fliY NC_009800.1 2019212 2020012 R identified by match to protein family HMM PF00497; cystine transporter subunit complement(2019212..2020012) Escherichia coli HS 5593829 YP_001458711.1 CDS fliA NC_009800.1 2020696 2021415 R sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes; flagellar biosynthesis sigma factor complement(2020696..2021415) Escherichia coli HS 5593747 YP_001458712.1 CDS EcHS_A2022 NC_009800.1 2021579 2022628 R identified by similarity to SP:Q08860; match to protein family HMM PF00669; match to protein family HMM PF00700; flagellin complement(2021579..2022628) Escherichia coli HS 5593748 YP_001458713.1 CDS fliD NC_009800.1 2022876 2024291 D involved in flagellin assembly; flagellar capping protein 2022876..2024291 Escherichia coli HS 5593204 YP_001458714.1 CDS fliS NC_009800.1 2024307 2024717 D flagellin specific chaperone; flagellar protein FliS 2024307..2024717 Escherichia coli HS 5593205 YP_001458715.1 CDS fliT NC_009800.1 2024717 2025082 D binds flagellar cap subunits (FliD) and seems to prevents their oligomerization prior to its translocation through the flagellum-specific type III export pathway; acts as a repressor of flagellar class 2 operons by preventing FlhD2C2 to bind the promoter and inhibiting the FlhD2C2-dependent transcription; member of the type III cytoplasmic chaperone family; flagellar biosynthesis protein FliT 2024717..2025082 Escherichia coli HS 5593206 YP_001458716.1 CDS amyA NC_009800.1 2025160 2026647 D converts 1,4-alpha-D-glucans to maltodextrin; cytoplasmic alpha-amylase 2025160..2026647 Escherichia coli HS 5593820 YP_001458717.1 CDS EcHS_A2028 NC_009800.1 2026681 2027097 R yedD; hypothetical protein complement(2026681..2027097) Escherichia coli HS 5593821 YP_001458718.1 CDS EcHS_A2029 NC_009800.1 2027281 2028486 D identified by match to protein family HMM PF04143; inner membrane protein 2027281..2028486 Escherichia coli HS 5593822 YP_001458719.1 CDS EcHS_A2030 NC_009800.1 2028483 2028716 D yedF; identified by match to protein family HMM PF01206; hypothetical protein 2028483..2028716 Escherichia coli HS 5595282 YP_001458720.1 CDS EcHS_A2031 NC_009800.1 2028825 2029322 D identified by match to protein family HMM PF02586; hypothetical protein 2028825..2029322 Escherichia coli HS 5595283 YP_001458721.1 CDS EcHS_A2033 NC_009800.1 2029204 2029533 R IS605 family transposase OrfB complement(2029204..2029533) Escherichia coli HS 5595284 YP_001458722.1 CDS EcHS_A2032 NC_009800.1 2029511 2030011 D identified by match to protein family HMM PF01797; IS605 family transposase 2029511..2030011 Escherichia coli HS 5593655 YP_001458723.1 CDS EcHS_A2034 NC_009800.1 2030237 2031034 R AraC family transcriptional regulator complement(2030237..2031034) Escherichia coli HS 5593656 YP_001458724.1 CDS EcHS_A2035 NC_009800.1 2031044 2031595 R DLP12 prophage; similar to PEBP/RK1P protein family in eukaryotes that inhibits MEK phosphorylation by Raf-1; crystal structure suggests similar properties but exact function is unknown; kinase inhibitor complement(2031044..2031595) Escherichia coli HS 5593657 YP_001458725.1 CDS emrE NC_009800.1 2031764 2032096 R member of the small MDR (multidrug resistance) family of transporters; in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin; proton-dependent secondary transporter which exchanges protons for compound translocation; multidrug efflux protein complement(2031764..2032096) Escherichia coli HS 5591126 YP_001458726.1 CDS fliE NC_009800.1 2032440 2032754 R forms a junction between the M-ring and FlgB during flagella biosynthesis; flagellar hook-basal body protein FliE complement(2032440..2032754) Escherichia coli HS 5591127 YP_001458727.1 CDS fliF NC_009800.1 2032969 2034627 D the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod; flagellar MS-ring protein 2032969..2034627 Escherichia coli HS 5591128 YP_001458728.1 CDS fliG NC_009800.1 2034620 2035615 D One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein G 2034620..2035615 Escherichia coli HS 5594017 YP_001458729.1 CDS fliH NC_009800.1 2035608 2036294 D binds to and inhibits the function of flagella specific ATPase FliI; flagellar assembly protein H 2035608..2036294 Escherichia coli HS 5594018 YP_001458730.1 CDS fliI NC_009800.1 2036294 2037667 D involved in type III protein export during flagellum assembly; flagellum-specific ATP synthase 2036294..2037667 Escherichia coli HS 5594019 YP_001458731.1 CDS fliJ NC_009800.1 2037686 2038129 D rod/hook and filament chaperone; flagellar biosynthesis chaperone 2037686..2038129 Escherichia coli HS 5593032 YP_001458732.1 CDS fliK NC_009800.1 2038126 2039253 D identified by similarity to SP:P52614; match to protein family HMM PF02120; flagellar hook-length control protein 2038126..2039253 Escherichia coli HS 5593033 YP_001458733.1 CDS fliL NC_009800.1 2039358 2039822 D interacts with cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring; flagellar basal body protein FliL 2039358..2039822 Escherichia coli HS 5593034 YP_001458734.1 CDS fliM NC_009800.1 2039827 2040831 D with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation; flagellar motor switch protein FliM 2039827..2040831 Escherichia coli HS 5593927 YP_001458735.1 CDS fliN NC_009800.1 2040828 2041241 D One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein FliN 2040828..2041241 Escherichia coli HS 5593928 YP_001458736.1 CDS fliO NC_009800.1 2041244 2041609 D with FlhA, FlhB, FliP, FliQ and FliR is one of the membrane components of the flagellar export apparatus; flagellar biosynthesis protein FliO 2041244..2041609 Escherichia coli HS 5593929 YP_001458737.1 CDS fliP NC_009800.1 2041609 2042346 D FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliP 2041609..2042346 Escherichia coli HS 5595291 YP_001458738.1 CDS fliQ NC_009800.1 2042356 2042625 D with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliQ 2042356..2042625 Escherichia coli HS 5595292 YP_001458739.1 CDS fliR NC_009800.1 2042633 2043418 D FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliR 2042633..2043418 Escherichia coli HS 5595293 YP_001458740.1 CDS rcsA NC_009800.1 2043708 2044331 D identified by match to protein family HMM PF00196; colanic acid capsular biosynthesis activation protein A 2043708..2044331 Escherichia coli HS 5593778 YP_001458741.1 CDS EcHS_A2052 NC_009800.1 2044375 2044563 R identified by similarity to OMNI:NTL01SF1877; hypothetical protein complement(2044375..2044563) Escherichia coli HS 5593779 YP_001458742.1 CDS EcHS_A2053 NC_009800.1 2044726 2044953 D hypothetical protein 2044726..2044953 Escherichia coli HS 5593780 YP_001458743.1 CDS EcHS_A2054 NC_009800.1 2044999 2045109 D identified by glimmer; hypothetical protein 2044999..2045109 Escherichia coli HS 5591552 YP_001458744.1 CDS EcHS_A2059 NC_009800.1 2047995 2048177 R identified by similarity to SP:P64517; hypothetical protein complement(2047995..2048177) Escherichia coli HS 5594077 YP_001458745.1 CDS EcHS_A2060 NC_009800.1 2048256 2049173 R identified by match to protein family HMM PF05661; hypothetical protein complement(2048256..2049173) Escherichia coli HS 5594078 YP_001458746.1 CDS EcHS_A2061 NC_009800.1 2049346 2050266 D identified by match to protein family HMM PF00892; match to protein family HMM TIGR00950; hypothetical protein 2049346..2050266 Escherichia coli HS 5594079 YP_001458747.1 CDS vsr NC_009800.1 2050255 2050725 R identified by similarity to SP:P09184; match to protein family HMM PF03852; match to protein family HMM TIGR00632; very short patch repair protein complement(2050255..2050725) Escherichia coli HS 5594135 YP_001458748.1 CDS dcm NC_009800.1 2050706 2052124 R identified by similarity to SP:P0AED9; match to protein family HMM PF00145; match to protein family HMM TIGR00675; DNA cytosine methylase complement(2050706..2052124) Escherichia coli HS 5594136 YP_001458749.1 CDS EcHS_A2064 NC_009800.1 2052191 2052871 R identified by match to protein family HMM PF01966; hypothetical protein complement(2052191..2052871) Escherichia coli HS 5594137 YP_001458750.1 CDS EcHS_A2065 NC_009800.1 2052898 2053176 D identified by match to protein family HMM PF01527; ISEhe3, transposase orfA 2052898..2053176 Escherichia coli HS 5594219 YP_001458751.1 CDS EcHS_A2066 NC_009800.1 2053233 2054045 D identified by similarity to GB:AAP17067.1; match to protein family HMM PF00665; ISEhe3, transposase orfB 2053233..2054045 Escherichia coli HS 5594220 YP_001458752.1 CDS EcHS_A2067 NC_009800.1 2054141 2054344 D outer membrane protein, truncation 2054141..2054344 Escherichia coli HS 5594221 YP_001458753.1 CDS hchA NC_009800.1 2054935 2055786 D Hsp31 stabilizes early unfolding protein intermediates under severe heat stress; chaperone protein HchA 2054935..2055786 Escherichia coli HS 5593137 YP_001458754.1 CDS EcHS_A2069 NC_009800.1 2055894 2057252 R identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM TIGR01386; heavy metal sensor histidine kinase complement(2055894..2057252) Escherichia coli HS 5593138 YP_001458755.1 CDS EcHS_A2070 NC_009800.1 2057252 2058034 R induced by CusR in the presence of copper; YedW induces the expression of the upstream gene yedV (encoding a sensor kinase) as well as yedW; yedVW is one of four copper regulons found in E. coli; part of the copper homeostasis mechanism; confers resistance to copper and several drugs when induced; transcriptional regulatory protein YedW complement(2057252..2058034) Escherichia coli HS 5593139 YP_001458756.1 CDS EcHS_A2071 NC_009800.1 2058056 2058469 D identified by match to protein family HMM PF00576; match to protein family HMM TIGR02962; transthyretin family protein 2058056..2058469 Escherichia coli HS 5594118 YP_001458757.1 CDS EcHS_A2072 NC_009800.1 2058578 2059582 D in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ; sulfite oxidase subunit YedY 2058578..2059582 Escherichia coli HS 5594119 YP_001458758.1 CDS EcHS_A2073 NC_009800.1 2059583 2060218 D in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme; sulfite oxidase subunit YedZ 2059583..2060218 Escherichia coli HS 5594120 YP_001458759.1 CDS EcHS_A2074 NC_009800.1 2060475 2061125 D identified by similarity to SP:P76344; match to protein family HMM PF09223; hypothetical protein 2060475..2061125 Escherichia coli HS 5595330 YP_001458760.1 CDS EcHS_A2075 NC_009800.1 2061468 2061998 D identified by match to protein family HMM PF01292; nickel-dependent hydrogenase, b-type cytochrome subunit 2061468..2061998 Escherichia coli HS 5595331 YP_001458761.1 CDS EcHS_A2076 NC_009800.1 2062900 2063292 R identified by glimmer; hypothetical protein complement(2062900..2063292) Escherichia coli HS 5595332 YP_001458762.1 CDS EcHS_A2077 NC_009800.1 2063302 2063505 R identified by glimmer; hypothetical protein complement(2063302..2063505) Escherichia coli HS 5593346 YP_001458763.1 CDS EcHS_A2078 NC_009800.1 2064503 2064604 D membrane protein; identified by glimmer; hypothetical protein 2064503..2064604 Escherichia coli HS 5593347 YP_001458764.1 CDS EcHS_A2079 NC_009800.1 2064812 2065612 R identified by glimmer; hypothetical protein complement(2064812..2065612) Escherichia coli HS 5593348 YP_001458765.1 CDS EcHS_A2080 NC_009800.1 2065622 2067616 R identified by glimmer; hypothetical protein complement(2065622..2067616) Escherichia coli HS 5594403 YP_001458766.1 CDS EcHS_A2081 NC_009800.1 2067981 2069072 D identified by match to protein family HMM PF01757; acyltransferase 2067981..2069072 Escherichia coli HS 5594404 YP_001458767.1 CDS EcHS_A2082 NC_009800.1 2069051 2069836 R bacteriophage tail fiber protein-like; hypothetical protein complement(2069051..2069836) Escherichia coli HS 5594405 YP_001458768.1 CDS EcHS_A2083 NC_009800.1 2069863 2070537 R hypothetical protein complement(2069863..2070537) Escherichia coli HS 5594494 YP_001458769.1 CDS EcHS_A2084 NC_009800.1 2070534 2071682 R identified by match to protein family HMM PF04865; baseplate J protein complement(2070534..2071682) Escherichia coli HS 5594495 YP_001458770.1 CDS EcHS_A2085 NC_009800.1 2071672 2072121 R identified by match to protein family HMM PF07409; phage protein GP46 complement(2071672..2072121) Escherichia coli HS 5594496 YP_001458771.1 CDS EcHS_A2086 NC_009800.1 2072118 2072699 R identified by match to protein family HMM PF06890; match to protein family HMM TIGR01644; bacteriophage Mu Gp45 protein complement(2072118..2072699) Escherichia coli HS 5593000 YP_001458772.1 CDS EcHS_A2087 NC_009800.1 2072696 2073781 R identified by match to protein family HMM PF06893; bacteriophage Mu P protein complement(2072696..2073781) Escherichia coli HS 5593001 YP_001458773.1 CDS EcHS_A2088 NC_009800.1 2073778 2074164 R bacteriophage protein; hypothetical protein complement(2073778..2074164) Escherichia coli HS 5593002 YP_001458774.1 CDS EcHS_A2089 NC_009800.1 2074088 2074597 R phage protien-like; identified by glimmer; hypothetical protein complement(2074088..2074597) Escherichia coli HS 5595285 YP_001458775.1 CDS EcHS_A2090 NC_009800.1 2074597 2075187 R identified by glimmer; hypothetical protein complement(2074597..2075187) Escherichia coli HS 5595286 YP_001458776.1 CDS EcHS_A2091 NC_009800.1 2075189 2076055 R identified by match to protein family HMM PF01343; S49 family peptidase complement(2075189..2076055) Escherichia coli HS 5595287 YP_001458777.1 CDS EcHS_A2092 NC_009800.1 2076052 2077626 R identified by match to protein family HMM PF05136; match to protein family HMM TIGR01539; lambda family phage portal protein complement(2076052..2077626) Escherichia coli HS 5594161 YP_001458778.1 CDS EcHS_A2093 NC_009800.1 2077686 2077949 R identified by glimmer; hypothetical protein complement(2077686..2077949) Escherichia coli HS 5594162 YP_001458779.1 CDS EcHS_A2094 NC_009800.1 2077958 2080084 R identified by match to protein family HMM PF05876; Phage terminase large subunit (GpA) complement(2077958..2080084) Escherichia coli HS 5594163 YP_001458780.1 CDS EcHS_A2095 NC_009800.1 2080026 2080589 R hypothetical protein complement(2080026..2080589) Escherichia coli HS 5594488 YP_001458781.1 CDS EcHS_A2097 NC_009800.1 2080837 2081361 R identified by glimmer; hypothetical protein complement(2080837..2081361) Escherichia coli HS 5594489 YP_001458782.1 CDS EcHS_A2096 NC_009800.1 2081355 2081957 D identified by match to protein family HMM PF00589; phage integrase 2081355..2081957 Escherichia coli HS 5594490 YP_001458783.1 CDS EcHS_A2099 NC_009800.1 2082253 2083050 D yeeI; identified by similarity to SP:P76346; match to protein family HMM PF06167; hypothetical protein 2082253..2083050 Escherichia coli HS 5594227 YP_001458784.1 CDS EcHS_A2103 NC_009800.1 2090879 2091931 R hypothetical protein complement(2090879..2091931) Escherichia coli HS 5594448 YP_001458785.1 CDS shiA NC_009800.1 2092246 2093562 D identified by match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM TIGR00883; shikimate transporter 2092246..2093562 Escherichia coli HS 5594449 YP_001458786.1 CDS amn NC_009800.1 2093664 2095118 D Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile; AMP nucleosidase 2093664..2095118 Escherichia coli HS 5594450 YP_001458787.1 CDS EcHS_A2106 NC_009800.1 2095461 2096177 D yeeN; identified by match to protein family HMM PF01709; match to protein family HMM TIGR01033; hypothetical protein 2095461..2096177 Escherichia coli HS 5594610 YP_001458788.1 CDS EcHS_A2108 NC_009800.1 2096806 2098446 R identified by match to protein family HMM PF01554; match to protein family HMM TIGR00797; hypothetical protein complement(2096806..2098446) Escherichia coli HS 5594612 YP_001458789.1 CDS cbl NC_009800.1 2098567 2099517 R LysR-type transcriptional regulator similar to CysB; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates two operons consisting of ABC transporters that are part of the cys regulon; regulated by CysB; transcriptional regulator Cbl complement(2098567..2099517) Escherichia coli HS 5595386 YP_001458790.1 CDS nac NC_009800.1 2099619 2100536 R Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation; nitrogen assimilation transcriptional regulator complement(2099619..2100536) Escherichia coli HS 5594687 YP_001458791.1 CDS EcHS_A2113 NC_009800.1 2100993 2101925 R erfK; identified by match to protein family HMM PF03734; hypothetical protein complement(2100993..2101925) Escherichia coli HS 5594699 YP_001458792.1 CDS cobT NC_009800.1 2101990 2103069 R catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase complement(2101990..2103069) Escherichia coli HS 5594700 YP_001458793.1 CDS cobS NC_009800.1 2103081 2103824 R catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole; cobalamin synthase complement(2103081..2103824) Escherichia coli HS 5594797 YP_001458794.1 CDS cobU NC_009800.1 2103821 2104366 R catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP; adenosylcobinamide kinase complement(2103821..2104366) Escherichia coli HS 5594798 YP_001458795.1 CDS EcHS_A2117 NC_009800.1 2104500 2104640 R identified by similarity to GB:AAZ88711.1; hypothetical protein complement(2104500..2104640) Escherichia coli HS 5594799 YP_001458796.1 CDS EcHS_A2118 NC_009800.1 2104831 2104995 R identified by similarity to GB:AAN80940.1; hypothetical protein complement(2104831..2104995) Escherichia coli HS 5594648 YP_001458797.1 CDS EcHS_A2119 NC_009800.1 2105843 2106673 D identified by match to protein family HMM PF02126; phosphotriesterase 2105843..2106673 Escherichia coli HS 5594649 YP_001458798.1 CDS EcHS_A2120 NC_009800.1 2106713 2106889 R gamma-glutamyltranspeptidase, truncation complement(2106713..2106889) Escherichia coli HS 5594650 YP_001458799.1 CDS EcHS_A2121 NC_009800.1 2106943 2107368 D identified by match to protein family HMM PF01527; IS66 family orf1 2106943..2107368 Escherichia coli HS 5594584 YP_001458800.1 CDS EcHS_A2122 NC_009800.1 2107365 2107715 D identified by match to protein family HMM PF05717; IS66 family orf2 2107365..2107715 Escherichia coli HS 5594585 YP_001458801.1 CDS EcHS_A2123 NC_009800.1 2107746 2109359 D identified by match to protein family HMM PF03050; IS66 family transposase 2107746..2109359 Escherichia coli HS 5594586 YP_001458802.1 CDS EcHS_A2128 NC_009800.1 2111529 2111939 R identified by similarity to GB:AAL08463.1; hypothetical protein complement(2111529..2111939) Escherichia coli HS 5595402 YP_001458803.1 CDS EcHS_A2131 NC_009800.1 2113103 2113495 R identified by similarity to GB:AAK00467.1; hypothetical protein complement(2113103..2113495) Escherichia coli HS 5594774 YP_001458804.1 CDS EcHS_A2132 NC_009800.1 2113661 2114230 R identified by similarity to GB:AAL08464.2; hypothetical protein complement(2113661..2114230) Escherichia coli HS 5594775 YP_001458805.1 CDS EcHS_A2133 NC_009800.1 2114465 2114602 D identified by glimmer; hypothetical protein 2114465..2114602 Escherichia coli HS 5594834 YP_001458806.1 CDS EcHS_A2134 NC_009800.1 2114946 2115122 R identified by match to protein family HMM PF05321; hemolysin expression modulating protein complement(2114946..2115122) Escherichia coli HS 5594835 YP_001458807.1 CDS EcHS_A2135 NC_009800.1 2115758 2116036 D identified by match to protein family HMM PF05930; prophage CP4-57 regulatory protein AlpA 2115758..2116036 Escherichia coli HS 5594836 YP_001458808.1 CDS EcHS_A2136 NC_009800.1 2116125 2116733 D identified by similarity to GB:AAL08467.1; hypothetical protein 2116125..2116733 Escherichia coli HS 5594858 YP_001458809.1 CDS EcHS_A2137 NC_009800.1 2117919 2118836 D hypothetical protein 2117919..2118836 Escherichia coli HS 5594859 YP_001458810.1 CDS EcHS_A2138 NC_009800.1 2118921 2119793 D identified by match to protein family HMM PF01926; GTPase 2118921..2119793 Escherichia coli HS 5594860 YP_001458811.1 CDS EcHS_A2139 NC_009800.1 2120165 2121916 D identified by similarity to SP:P39180; antigen 43, truncation 2120165..2121916 Escherichia coli HS 5595409 YP_001458812.1 CDS EcHS_A2140 NC_009800.1 2122259 2122636 D identified by similarity to GB:ABB61174.1; match to protein family HMM PF06755; hypothetical protein 2122259..2122636 Escherichia coli HS 5595410 YP_001458813.1 CDS EcHS_A2141 NC_009800.1 2122633 2122836 D identified by similarity to GB:AAP18298.1; hypothetical protein 2122633..2122836 Escherichia coli HS 5595411 YP_001458814.1 CDS EcHS_A2142 NC_009800.1 2122846 2122962 D identified by similarity to GB:AAK00484.1; hypothetical protein 2122846..2122962 Escherichia coli HS 5594432 YP_001458815.1 CDS EcHS_A2143 NC_009800.1 2123678 2123818 D identified by glimmer; hypothetical protein 2123678..2123818 Escherichia coli HS 5594433 YP_001458816.1 CDS EcHS_A2144 NC_009800.1 2124420 2124785 D NULL; identified by similarity to SP:Q9XDM6; eutP/pduV family protein 2124420..2124785 Escherichia coli HS 5594434 YP_001458817.1 CDS EcHS_A2145 NC_009800.1 2124886 2125215 R identified by similarity to SP:P0A8M9; match to protein family HMM PF04363; hypothetical protein complement(2124886..2125215) Escherichia coli HS 5594665 YP_001458818.1 CDS EcHS_A2146 NC_009800.1 2125387 2126445 R hypothetical protein complement(2125387..2126445) Escherichia coli HS 5594666 YP_001458819.1 CDS gyrI NC_009800.1 2126643 2127116 R identified by similarity to GB:1JYH_A; match to protein family HMM PF06445; DNA gyrase inhibitor complement(2126643..2127116) Escherichia coli HS 5594667 YP_001458820.1 CDS dacD NC_009800.1 2127235 2128401 R removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; penicillin-binding protein 6B; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase complement(2127235..2128401) Escherichia coli HS 5594312 YP_001458821.1 CDS sbcB NC_009800.1 2128610 2130037 D Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates; exonuclease I 2128610..2130037 Escherichia coli HS 5594313 YP_001458822.1 CDS EcHS_A2150 NC_009800.1 2130080 2130307 R yeeD; identified by similarity to GB:AAZ88738.1; match to protein family HMM PF01206; hypothetical protein complement(2130080..2130307) Escherichia coli HS 5594314 YP_001458823.1 CDS EcHS_A2151 NC_009800.1 2130321 2131379 R identified by match to protein family HMM PF04143; hypothetical protein complement(2130321..2131379) Escherichia coli HS 5594819 YP_001458824.1 CDS yeeF NC_009800.1 2131558 2132916 R identified by match to protein family HMM PF00324; amino acid permease complement(2131558..2132916) Escherichia coli HS 5594820 YP_001458825.1 CDS EcHS_A2153 NC_009800.1 2133183 2134112 R identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator complement(2133183..2134112) Escherichia coli HS 5594821 YP_001458826.1 CDS EcHS_A2154 NC_009800.1 2134158 2134982 R identified by match to protein family HMM PF01073; match to protein family HMM PF01370; NAD dependent epimerase/dehydratase complement(2134158..2134982) Escherichia coli HS 5594822 YP_001458827.1 CDS yoeB NC_009800.1 2135065 2135319 R yoeB; identified by similarity to SP:P69349; match to protein family HMM PF06769; match to protein family HMM TIGR02116; addiction module toxin component YoeB complement(2135065..2135319) Escherichia coli HS 5594823 YP_001458828.1 CDS yefM NC_009800.1 2135316 2135567 R Antitoxin that counteracts the effect of the YoeB toxin; antitoxin YefM complement(2135316..2135567) Escherichia coli HS 5594824 YP_001458830.1 CDS hisG NC_009800.1 2136047 2136946 D long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase 2136047..2136946 Escherichia coli HS 5594906 YP_001458831.1 CDS hisD NC_009800.1 2136952 2138256 D catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 2136952..2138256 Escherichia coli HS 5594907 YP_001458832.1 CDS hisC NC_009800.1 2138253 2139323 D catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 2138253..2139323 Escherichia coli HS 5594693 YP_001458833.1 CDS hisB NC_009800.1 2139323 2140390 D catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate; imidazole glycerol-phosphate dehydratase/histidinol phosphatase 2139323..2140390 Escherichia coli HS 5594694 YP_001458834.1 CDS hisH NC_009800.1 2140390 2140980 D with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 2140390..2140980 Escherichia coli HS 5594695 YP_001458835.1 CDS hisA NC_009800.1 2140980 2141717 D catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 2140980..2141717 Escherichia coli HS 5591218 YP_001458836.1 CDS hisF NC_009800.1 2141699 2142475 D catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 2141699..2142475 Escherichia coli HS 5591219 YP_001458837.1 CDS hisIE NC_009800.1 2142469 2143077 D catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis; bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase 2142469..2143077 Escherichia coli HS 5591220 YP_001458838.1 CDS EcHS_A2166 NC_009800.1 2143116 2144231 R identified by match to protein family HMM PF00534; glycosyl transferase, group 1 family protein complement(2143116..2144231) Escherichia coli HS 5594718 YP_001458839.1 CDS mtfB NC_009800.1 2144241 2145386 R identified by similarity to GB:BAA07751.1; match to protein family HMM PF00534; mannosyltransferase complement(2144241..2145386) Escherichia coli HS 5594719 YP_001458840.1 CDS EcHS_A2168 NC_009800.1 2145433 2147880 R identified by similarity to GB:BAA07750.1; match to protein family HMM PF00534; glycosyl transferase, group 1 family protein complement(2145433..2147880) Escherichia coli HS 5594720 YP_001458841.1 CDS EcHS_A2169 NC_009800.1 2147966 2150092 R kinase-like; identified by match to protein family HMM PF08241; match to protein family HMM PF08242; hypothetical protein complement(2147966..2150092) Escherichia coli HS 5594947 YP_001458842.1 CDS EcHS_A2170 NC_009800.1 2150112 2151407 R identified by match to protein family HMM PF00005; ABC transporter complement(2150112..2151407) Escherichia coli HS 5594948 YP_001458843.1 CDS EcHS_A2171 NC_009800.1 2151410 2152195 R identified by match to protein family HMM PF01061; ABC-2 type transporter complement(2151410..2152195) Escherichia coli HS 5594949 YP_001458844.1 CDS EcHS_A2172 NC_009800.1 2152201 2153583 R identified by match to protein family HMM PF00408; match to protein family HMM PF02878; match to protein family HMM PF02879; match to protein family HMM PF02880; phosphomannomutase complement(2152201..2153583) Escherichia coli HS 5591221 YP_001458845.1 CDS manC NC_009800.1 2153607 2155022 R identified by similarity to SP:P24174; match to protein family HMM PF00483; match to protein family HMM PF01050; match to protein family HMM PF07883; match to protein family HMM TIGR01479; mannose-1-phosphate guanylyltransferase complement(2153607..2155022) Escherichia coli HS 5591222 YP_001458846.1 CDS EcHS_A2174 NC_009800.1 2155033 2155125 R identified by glimmer; hypothetical protein complement(2155033..2155125) Escherichia coli HS 5591223 YP_001458847.1 CDS EcHS_A2175 NC_009800.1 2155699 2155809 R identified by glimmer; hypothetical protein complement(2155699..2155809) Escherichia coli HS 5594545 YP_001458848.1 CDS EcHS_A2176 NC_009800.1 2156091 2156588 R identified by match to protein family HMM PF03400; IS1, transposase orfB complement(2156091..2156588) Escherichia coli HS 5594546 YP_001458849.1 CDS EcHS_A2177 NC_009800.1 2156507 2156782 R identified by match to protein family HMM PF03811; IS1, transposase orfA complement(2156507..2156782) Escherichia coli HS 5594547 YP_001458850.1 CDS ugd NC_009800.1 2156840 2158006 R identified by similarity to SP:P76373; match to protein family HMM PF00984; match to protein family HMM PF03720; match to protein family HMM PF03721; match to protein family HMM TIGR03026; UDP-glucose 6-dehydrogenase complement(2156840..2158006) Escherichia coli HS 5594708 YP_001458851.1 CDS rfbC NC_009800.1 2158187 2158741 R identified by match to protein family HMM PF00908; match to protein family HMM TIGR01221; dTDP-4-dehydrorhamnose 3,5-epimerase complement(2158187..2158741) Escherichia coli HS 5594709 YP_001458852.1 CDS rfbD NC_009800.1 2158756 2159646 R identified by match to protein family HMM PF01370; match to protein family HMM PF04321; match to protein family HMM TIGR01214; dTDP-4-dehydrorhamnose reductase complement(2158756..2159646) Escherichia coli HS 5594710 YP_001458853.1 CDS rfbA2 NC_009800.1 2159678 2160547 R identified by match to protein family HMM PF00483; match to protein family HMM TIGR01207; glucose-1-phosphate thymidylyltransferase complement(2159678..2160547) Escherichia coli HS 5594767 YP_001458854.1 CDS rfbB1 NC_009800.1 2160574 2161638 R identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993; match to protein family HMM TIGR01181; dTDP-glucose 4,6-dehydratase complement(2160574..2161638) Escherichia coli HS 5594768 YP_001458855.1 CDS gnd NC_009800.1 2161862 2163268 R catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase complement(2161862..2163268) Escherichia coli HS 5594769 YP_001458856.1 CDS EcHS_A2184 NC_009800.1 2163469 2164899 R identified by match to protein family HMM PF01943; polysaccharide biosynthesis protein complement(2163469..2164899) Escherichia coli HS 5594251 YP_001458857.1 CDS EcHS_A2185 NC_009800.1 2164982 2165833 R hypothetical protein complement(2164982..2165833) Escherichia coli HS 5594252 YP_001458858.1 CDS EcHS_A2186 NC_009800.1 2165826 2167076 R hypothetical protein complement(2165826..2167076) Escherichia coli HS 5594253 YP_001458859.1 CDS EcHS_A2187 NC_009800.1 2167078 2167848 R identified by match to protein family HMM PF00535; glycosyl transferase, group 2 family protein complement(2167078..2167848) Escherichia coli HS 5595297 YP_001458860.1 CDS EcHS_A2188 NC_009800.1 2167880 2169673 R identified by glimmer; hypothetical protein complement(2167880..2169673) Escherichia coli HS 5595298 YP_001458861.1 CDS EcHS_A2189 NC_009800.1 2170120 2171031 R identified by match to protein family HMM PF00535; glycosyl transferase, group 2 family protein complement(2170120..2171031) Escherichia coli HS 5595299 YP_001458862.1 CDS EcHS_A2190 NC_009800.1 2171069 2172496 R identified by match to protein family HMM PF02397; match to protein family HMM TIGR03022; match to protein family HMM TIGR03025; sugar transferase complement(2171069..2172496) Escherichia coli HS 5594125 YP_001458863.1 CDS etk2 NC_009800.1 2172599 2174767 R identified by similarity to SP:P38134; match to protein family HMM PF02706; tyrosine-protein kinase etk complement(2172599..2174767) Escherichia coli HS 5594126 YP_001458864.1 CDS wzb NC_009800.1 2174782 2175219 R identified by similarity to SP:P0AAB2; match to protein family HMM PF01451; low molecular weight phosphotyrosine protein phosphatase complement(2174782..2175219) Escherichia coli HS 5594127 YP_001458865.1 CDS EcHS_A2193 NC_009800.1 2175221 2176357 R identified by similarity to SP:Q48450; match to protein family HMM PF02563; polysaccharide biosynthesis/export protein complement(2175221..2176357) Escherichia coli HS 5594349 YP_001458866.1 CDS EcHS_A2194 NC_009800.1 2176501 2178015 R identified by similarity to GB:AAV27321.1; hypothetical protein complement(2176501..2178015) Escherichia coli HS 5594350 YP_001458867.1 CDS EcHS_A2195 NC_009800.1 2178147 2178287 R identified by glimmer; hypothetical protein complement(2178147..2178287) Escherichia coli HS 5594351 YP_001458868.1 CDS EcHS_A2196 NC_009800.1 2178262 2178363 R identified by glimmer; hypothetical protein complement(2178262..2178363) Escherichia coli HS 5593951 YP_001458869.1 CDS EcHS_A2197 NC_009800.1 2178508 2178783 D identified by match to protein family HMM PF03811; IS1, transposase orfA 2178508..2178783 Escherichia coli HS 5593952 YP_001458870.1 CDS EcHS_A2198 NC_009800.1 2178702 2179205 D identified by match to protein family HMM PF03400; IS1, transposase orfB 2178702..2179205 Escherichia coli HS 5593953 YP_001458871.1 CDS EcHS_A2199 NC_009800.1 2179302 2179538 R identified by glimmer; hypothetical protein complement(2179302..2179538) Escherichia coli HS 5593954 YP_001458872.1 CDS galF NC_009800.1 2180315 2181217 R together with GalU subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; UTP-glucose-1-phosphate uridylyltransferase complement(2180315..2181217) Escherichia coli HS 5593956 YP_001458873.1 CDS asmA NC_009800.1 2184001 2185854 R YegA; inner membrane protein involved in the assembly of outer membrane proteins (OMPs); asmA-null mutants show low lipopolysaccharide (LPS) levels, suggesting a role in LPS biogenesis and/or in restricting outer membrane fluidity, resulting on altered assembly of OMPs; assembly protein complement(2184001..2185854) Escherichia coli HS 5593647 YP_001458874.1 CDS dcd NC_009800.1 2185876 2186457 R Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase complement(2185876..2186457) Escherichia coli HS 5593648 YP_001458875.1 CDS udk NC_009800.1 2186549 2187190 R functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase complement(2186549..2187190) Escherichia coli HS 5592489 YP_001458876.1 CDS alkA NC_009800.1 2190934 2191782 R inducible, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine; 3-methyl-adenine DNA glycosylase complement(2190934..2191782) Escherichia coli HS 5592491 YP_001458877.1 CDS EcHS_A2210 NC_009800.1 2191916 2193268 D chaperone 2191916..2193268 Escherichia coli HS 5593324 YP_001458878.1 CDS EcHS_A2211 NC_009800.1 2193280 2195226 R hypothetical protein complement(2193280..2195226) Escherichia coli HS 5593325 YP_001458879.1 CDS EcHS_A2212 NC_009800.1 2195272 2195382 R identified by glimmer; hypothetical protein complement(2195272..2195382) Escherichia coli HS 5593326 YP_001458880.1 CDS EcHS_A2213 NC_009800.1 2195426 2195887 D yegJ; identified by glimmer; hypothetical protein 2195426..2195887 Escherichia coli HS 5592978 YP_001458881.1 CDS EcHS_A2214 NC_009800.1 2195952 2196713 R yegK; identified by similarity to SP:P76395; hypothetical protein complement(2195952..2196713) Escherichia coli HS 5592979 YP_001458882.1 CDS EcHS_A2215 NC_009800.1 2196710 2197369 R identified by match to protein family HMM PF00092; von Willebrand factor A complement(2196710..2197369) Escherichia coli HS 5592980 YP_001458883.1 CDS mdtA NC_009800.1 2198257 2199504 D Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtA 2198257..2199504 Escherichia coli HS 5592055 YP_001458884.1 CDS mdtB NC_009800.1 2199504 2202626 D Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtB 2199504..2202626 Escherichia coli HS 5592907 YP_001458885.1 CDS mdtC NC_009800.1 2202627 2205704 D Part of a tripartite efflux system composed of MdtA, MdtB and MdtC; confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtC 2202627..2205704 Escherichia coli HS 5592908 YP_001458886.1 CDS EcHS_A2219 NC_009800.1 2205705 2207120 D identified by match to protein family HMM PF07690; multidrug efflux system protein MdtE 2205705..2207120 Escherichia coli HS 5592909 YP_001458887.1 CDS baeS NC_009800.1 2207117 2208520 D identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; signal transduction histidine-protein kinase BaeS 2207117..2208520 Escherichia coli HS 5592989 YP_001458888.1 CDS baeR NC_009800.1 2208517 2209239 D response regulator in two-component regulatory system with BaeS; regulator of RNA synthesis, flagellar biosynthesis, chemotaxis and transport; DNA-binding transcriptional regulator BaeR 2208517..2209239 Escherichia coli HS 5592990 YP_001458889.1 CDS EcHS_A2222 NC_009800.1 2209430 2209762 D hypothetical protein 2209430..2209762 Escherichia coli HS 5592991 YP_001458890.1 CDS EcHS_A2224 NC_009800.1 2211601 2211978 R identified by similarity to GB:ABB65576.1; hypothetical protein complement(2211601..2211978) Escherichia coli HS 5592642 YP_001458891.1 CDS EcHS_A2225 NC_009800.1 2212324 2213223 D cytosolic protein with phosphatidylglycerol kinase activity; undetermined physiological role; lipid kinase 2212324..2213223 Escherichia coli HS 5592643 YP_001458892.1 CDS gatR NC_009800.1 2213305 2214078 R identified by similarity to SP:P36930; match to protein family HMM PF00455; match to protein family HMM PF08220; match to protein family HMM PF08279; galactitol utilization operon repressor complement(2213305..2214078) Escherichia coli HS 5592858 YP_001458893.1 CDS gatD NC_009800.1 2214184 2215224 R Zn-dependent; NAD(P)-binding; catalyzes the formation of tagatose-6-phosphate from galactitol-1-phosphate; galactitol-1-phosphate dehydrogenase complement(2214184..2215224) Escherichia coli HS 5592859 YP_001458894.1 CDS gatC NC_009800.1 2215272 2216627 R identified by match to protein family HMM PF03611; match to protein family HMM TIGR00827; PTS system, galactitol-specific IIC component complement(2215272..2216627) Escherichia coli HS 5592860 YP_001458895.1 CDS gatB NC_009800.1 2216631 2216915 R phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; galactitol-specific PTS system component IIB complement(2216631..2216915) Escherichia coli HS 5592861 YP_001458896.1 CDS gatA NC_009800.1 2216946 2217398 R phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; galactitol-specific PTS system component IIA complement(2216946..2217398) Escherichia coli HS 5592451 YP_001458897.1 CDS EcHS_A2231 NC_009800.1 2217408 2218670 R identified by match to protein family HMM PF08013; match to protein family HMM TIGR02810; tagatose-6-phosphate kinase complement(2217408..2218670) Escherichia coli HS 5592452 YP_001458898.1 CDS gatY NC_009800.1 2218699 2219553 R catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway; tagatose-bisphosphate aldolase complement(2218699..2219553) Escherichia coli HS 5592453 YP_001458899.1 CDS fbaB NC_009800.1 2219861 2220913 R catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate; fructose-bisphosphate aldolase complement(2219861..2220913) Escherichia coli HS 5592820 YP_001458900.1 CDS yegT NC_009800.1 2221170 2222447 D identified by match to protein family HMM PF03825; match to protein family HMM PF07690; match to protein family HMM TIGR00889; nucleoside transporter 2221170..2222447 Escherichia coli HS 5592821 YP_001458901.1 CDS EcHS_A2235 NC_009800.1 2222444 2223448 D yegU; identified by match to protein family HMM PF03747; ADP-ribosylglycohydrolase 2222444..2223448 Escherichia coli HS 5592822 YP_001458902.1 CDS EcHS_A2236 NC_009800.1 2223445 2224410 D identified by match to protein family HMM PF00294; PfkB family kinase 2223445..2224410 Escherichia coli HS 5592176 YP_001458903.1 CDS EcHS_A2237 NC_009800.1 2224384 2225130 R identified by match to protein family HMM PF00392; match to protein family HMM PF07702; match to protein family HMM PF08279; GntR family transcriptional regulator complement(2224384..2225130) Escherichia coli HS 5592177 YP_001458904.1 CDS EcHS_A2238 NC_009800.1 2225182 2226000 R yegX; identified by match to protein family HMM PF01183; glycosyl hydrolase complement(2225182..2226000) Escherichia coli HS 5592178 YP_001458905.1 CDS thiD NC_009800.1 2226065 2226865 R catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase complement(2226065..2226865) Escherichia coli HS 5591929 YP_001458906.1 CDS thiM NC_009800.1 2226862 2227650 R catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase complement(2226862..2227650) Escherichia coli HS 5591930 YP_001458907.1 CDS rcnR NC_009800.1 2227873 2228145 R yohL; identified by similarity to SP:P64530; match to protein family HMM PF02583; transcriptional repressor RcnR complement(2227873..2228145) Escherichia coli HS 5591931 YP_001458908.1 CDS rcnA NC_009800.1 2228266 2229090 D membrane protein conferring nickel and cobalt resistance; nickel/cobalt efflux protein RcnA 2228266..2229090 Escherichia coli HS 5591610 YP_001458909.1 CDS EcHS_A2243 NC_009800.1 2229129 2229647 D yohN; identified by similarity to GB:AAN81090.1; hypothetical protein 2229129..2229647 Escherichia coli HS 5591611 YP_001458910.1 CDS EcHS_A2244 NC_009800.1 2229729 2230763 R hypothetical protein complement(2229729..2230763) Escherichia coli HS 5591612 YP_001458911.1 CDS EcHS_A2245 NC_009800.1 2230779 2233259 R identified by match to protein family HMM PF00577; fimbrial usher protein complement(2230779..2233259) Escherichia coli HS 5591878 YP_001458912.1 CDS EcHS_A2246 NC_009800.1 2233275 2233949 R identified by match to protein family HMM PF00345; match to protein family HMM PF02753; pilus assembly chaperone complement(2233275..2233949) Escherichia coli HS 5591879 YP_001458913.1 CDS EcHS_A2247 NC_009800.1 2234029 2234571 R identified by match to protein family HMM PF00419; fimbrial protein complement(2234029..2234571) Escherichia coli HS 5591880 YP_001458914.1 CDS EcHS_A2248 NC_009800.1 2235408 2236517 R identified by similarity to SP:P0AF08; ATPase complement(2235408..2236517) Escherichia coli HS 5591326 YP_001458915.1 CDS metG NC_009800.1 2236649 2238682 D methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 2236649..2238682 Escherichia coli HS 5591327 YP_001458916.1 CDS molR NC_009800.1 2238823 2242617 D identified by similarity to SP:P33345; match to protein family HMM PF05406; molybdate metabolism regulator 2238823..2242617 Escherichia coli HS 5591328 YP_001458917.1 CDS EcHS_A2251 NC_009800.1 2242627 2246259 D identified by similarity to SP:P33345; molybdate metabolism regulator MolR-like protein 2242627..2246259 Escherichia coli HS 5591477 YP_001458918.1 CDS EcHS_A2252 NC_009800.1 2246320 2246637 D identified by glimmer; hypothetical protein 2246320..2246637 Escherichia coli HS 5591478 YP_001458919.1 CDS EcHS_A2253 NC_009800.1 2246944 2248032 D yehL; identified by match to protein family HMM PF07728; ATPase AAA 2246944..2248032 Escherichia coli HS 5591479 YP_001458920.1 CDS EcHS_A2254 NC_009800.1 2248043 2250322 D yehM; identified by similarity to SP:P33349; hypothetical protein 2248043..2250322 Escherichia coli HS 5595011 YP_001458921.1 CDS EcHS_A2255 NC_009800.1 2250315 2251451 D yehP; identified by match to protein family HMM PF00092; match to protein family HMM PF05762; von Willebrand factor A 2250315..2251451 Escherichia coli HS 5595012 YP_001458922.1 CDS EcHS_A2256 NC_009800.1 2251448 2253448 D yehQ; identified by match to protein family HMM PF04434; hypothetical protein 2251448..2253448 Escherichia coli HS 5595013 YP_001458923.1 CDS EcHS_A2257 NC_009800.1 2253573 2254034 D yehR; identified by match to protein family HMM PF06998; lipoprotein 2253573..2254034 Escherichia coli HS 5591381 YP_001458924.1 CDS EcHS_A2258 NC_009800.1 2254075 2254545 R yehS; identified by match to protein family HMM PF07308; hypothetical protein complement(2254075..2254545) Escherichia coli HS 5591382 YP_001458925.1 CDS EcHS_A2259 NC_009800.1 2254592 2255311 R unknown function; when overproduced it confers drug-resistance; two-component response-regulatory protein YehT complement(2254592..2255311) Escherichia coli HS 5591383 YP_001458926.1 CDS EcHS_A2260 NC_009800.1 2255308 2256993 R identified by match to protein family HMM PF01590; match to protein family HMM PF02518; match to protein family HMM PF06580; match to protein family HMM PF07694; sensor histidine kinase complement(2255308..2256993) Escherichia coli HS 5591307 YP_001458927.1 CDS EcHS_A2262 NC_009800.1 2258014 2258121 D identified by similarity to GB:AAZ88835.1; hypothetical protein 2258014..2258121 Escherichia coli HS 5591309 YP_001458928.1 CDS EcHS_A2263 NC_009800.1 2258102 2258833 R identified by match to protein family HMM PF00528; quaternary amine ABC transporter permease complement(2258102..2258833) Escherichia coli HS 5593674 YP_001458929.1 CDS EcHS_A2264 NC_009800.1 2258838 2259764 R identified by match to protein family HMM PF00005; quaternary amine ABC transporter ATP-binding protein complement(2258838..2259764) Escherichia coli HS 5593675 YP_001458930.1 CDS EcHS_A2265 NC_009800.1 2259757 2260914 R identified by match to protein family HMM PF00528; quaternary amine ABC transporter permease complement(2259757..2260914) Escherichia coli HS 5593676 YP_001458931.1 CDS EcHS_A2266 NC_009800.1 2260921 2261838 R identified by match to protein family HMM PF04069; quaternary amine ABC transporter periplasmic substrate-binding protein complement(2260921..2261838) Escherichia coli HS 5594999 YP_001458932.1 CDS bglX NC_009800.1 2262090 2264387 R identified by similarity to SP:P33363; match to protein family HMM PF00933; match to protein family HMM PF01915; beta-glucosidase, periplasmic complement(2262090..2264387) Escherichia coli HS 5595000 YP_001458933.1 CDS dld NC_009800.1 2264583 2266298 D component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent; D-lactate dehydrogenase 2264583..2266298 Escherichia coli HS 5595001 YP_001458934.1 CDS pbpG NC_009800.1 2266336 2267277 R specifically hydrolyze the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi; Penicillin-binding protein 7; D-alanyl-D-alanine endopeptidase complement(2266336..2267277) Escherichia coli HS 5591978 YP_001458935.1 CDS EcHS_A2270 NC_009800.1 2267442 2268029 R yohC; identified by match to protein family HMM PF06930; hypothetical protein complement(2267442..2268029) Escherichia coli HS 5591979 YP_001458936.1 CDS EcHS_A2271 NC_009800.1 2268199 2268777 D yohD; identified by similarity to SP:P33366; match to protein family HMM PF09335; hypothetical protein 2268199..2268777 Escherichia coli HS 5591980 YP_001458937.1 CDS EcHS_A2272 NC_009800.1 2268907 2269668 R identified by match to protein family HMM PF00106; acetoin dehydrogenase complement(2268907..2269668) Escherichia coli HS 5593614 YP_001458938.1 CDS EcHS_A2273 NC_009800.1 2269721 2271157 R may be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug resistance outer membrane protein MdtQ complement(2269721..2271157) Escherichia coli HS 5593615 YP_001458939.1 CDS dusC NC_009800.1 2271837 2272784 R identified by similarity to SP:P33371; match to protein family HMM PF01207; tRNA-dihydrouridine synthase C complement(2271837..2272784) Escherichia coli HS 5593616 YP_001458940.1 CDS EcHS_A2275 NC_009800.1 2273023 2273421 D yohJ; identified by match to protein family HMM PF03788; hypothetical protein 2273023..2273421 Escherichia coli HS 5592272 YP_001458941.1 CDS cdd NC_009800.1 2274243 2275127 D Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 2274243..2275127 Escherichia coli HS 5592274 YP_001458942.1 CDS sanA NC_009800.1 2275277 2275996 D identified by similarity to SP:P0AFY5; match to protein family HMM PF02698; hypothetical protein 2275277..2275996 Escherichia coli HS 5592644 YP_001458943.1 CDS EcHS_A2279 NC_009800.1 2275999 2276238 D yeiS; identified by similarity to SP:P64539; hypothetical protein 2275999..2276238 Escherichia coli HS 5592645 YP_001458944.1 CDS EcHS_A2280 NC_009800.1 2276432 2277670 D function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain; oxidoreductase 2276432..2277670 Escherichia coli HS 5592646 YP_001458945.1 CDS EcHS_A2281 NC_009800.1 2277664 2278899 D catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines; dihydropyrimidine dehydrogenase 2277664..2278899 Escherichia coli HS 5594158 YP_001458946.1 CDS mglC NC_009800.1 2278970 2279980 R ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex; beta-methylgalactoside transporter inner membrane component complement(2278970..2279980) Escherichia coli HS 5594159 YP_001458947.1 CDS mglA NC_009800.1 2279996 2281516 R with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains; galactose/methyl galaxtoside transporter ATP-binding protein complement(2279996..2281516) Escherichia coli HS 5594160 YP_001458948.1 CDS mglB NC_009800.1 2281577 2282575 R identified by similarity to SP:P0AEE5; match to protein family HMM PF00532; galactose ABC transporter periplasmic galactose-binding protein complement(2281577..2282575) Escherichia coli HS 5592657 YP_001458949.1 CDS galS NC_009800.1 2282855 2283895 R negative regulator of the mglBAC operon for galactose utilization; DNA-binding transcriptional regulator GalS complement(2282855..2283895) Escherichia coli HS 5592658 YP_001458950.1 CDS EcHS_A2286 NC_009800.1 2284037 2285194 R NULL; identified by match to protein family HMM PF04171; match to protein family HMM PF04235; hypothetical protein complement(2284037..2285194) Escherichia coli HS 5592659 YP_001458951.1 CDS folE NC_009800.1 2285211 2285879 R involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I complement(2285211..2285879) Escherichia coli HS 5594800 YP_001458952.1 CDS fghA1 NC_009800.1 2286137 2286973 D identified by match to protein family HMM PF00756; match to protein family HMM TIGR02821; S-formylglutathione hydrolase 2286137..2286973 Escherichia coli HS 5594801 YP_001458953.1 CDS cirA NC_009800.1 2287005 2288996 R Cir; FeuA; CirA; receptor protein for siderophores (colicin IA, IB and V) and microcins (E492, H47, and M); TonB-dependent; able to transport monomers, dimer, and linear trimers of 2,3-dihydorxybenzoylserine; outer membrane protein; colicin I receptor complement(2287005..2288996) Escherichia coli HS 5594802 YP_001458954.1 CDS EcHS_A2290 NC_009800.1 2289089 2289193 R identified by glimmer; hypothetical protein complement(2289089..2289193) Escherichia coli HS 5591685 YP_001458955.1 CDS lysP NC_009800.1 2289290 2290759 R identified by match to protein family HMM PF00324; lysine transporter complement(2289290..2290759) Escherichia coli HS 5591686 YP_001458956.1 CDS EcHS_A2292 NC_009800.1 2290867 2290977 R identified by glimmer; hypothetical protein complement(2290867..2290977) Escherichia coli HS 5591687 YP_001458957.1 CDS EcHS_A2293 NC_009800.1 2290964 2291845 R identified by match to protein family HMM PF00126; match to protein family HMM PF03466; DNA-binding transcriptional regulator complement(2290964..2291845) Escherichia coli HS 5591947 YP_001458958.1 CDS EcHS_A2294 NC_009800.1 2291944 2292993 D yeiH; identified by match to protein family HMM PF03601; match to protein family HMM TIGR00698; hypothetical protein 2291944..2292993 Escherichia coli HS 5591948 YP_001458959.1 CDS nfo NC_009800.1 2293067 2293924 D Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues; endonuclease IV 2293067..2293924 Escherichia coli HS 5591949 YP_001458960.1 CDS EcHS_A2296 NC_009800.1 2293927 2295015 D identified by match to protein family HMM PF00294; match to protein family HMM PF08279; hypothetical protein 2293927..2295015 Escherichia coli HS 5591813 YP_001458961.1 CDS EcHS_A2297 NC_009800.1 2295071 2296321 R identified by match to protein family HMM PF01773; match to protein family HMM PF07662; match to protein family HMM PF07670; match to protein family HMM TIGR00804; NupC family nucleoside transporter complement(2295071..2296321) Escherichia coli HS 5591814 YP_001458962.1 CDS rihB NC_009800.1 2296421 2297362 R Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively; ribonucleoside hydrolase 2 complement(2296421..2297362) Escherichia coli HS 5591815 YP_001458963.1 CDS nsr NC_009800.1 2297531 2298190 D activator of nucleoside metabolism; DNA-binding transcriptional activator YeiL 2297531..2298190 Escherichia coli HS 5594941 YP_001458964.1 CDS EcHS_A2302 NC_009800.1 2299606 2300544 R identified by match to protein family HMM PF04227; indigoidine synthase A like protein complement(2299606..2300544) Escherichia coli HS 5594943 YP_001458965.1 CDS EcHS_A2303 NC_009800.1 2300532 2301473 R yeiC; identified by match to protein family HMM PF00294; hypothetical protein complement(2300532..2301473) Escherichia coli HS 5591229 YP_001458966.1 CDS fruA NC_009800.1 2301897 2303588 R phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; fructose-specific PTS system IIBC component complement(2301897..2303588) Escherichia coli HS 5591230 YP_001458967.1 CDS fruK NC_009800.1 2303605 2304543 R converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers; 1-phosphofructokinase complement(2303605..2304543) Escherichia coli HS 5591231 YP_001458968.1 CDS fruB NC_009800.1 2304543 2305673 R phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr; bifunctional fructose-specific PTS IIA/HPr protein complement(2304543..2305673) Escherichia coli HS 5594335 YP_001458969.1 CDS EcHS_A2307 NC_009800.1 2305839 2305970 D identified by similarity to GB:AAN81159.1; hypothetical protein 2305839..2305970 Escherichia coli HS 5594336 YP_001458970.1 CDS setB NC_009800.1 2306041 2307222 D identified by match to protein family HMM PF07690; match to protein family HMM TIGR00899; sugar efflux transporter B 2306041..2307222 Escherichia coli HS 5594337 YP_001458971.1 CDS EcHS_A2309 NC_009800.1 2307373 2308200 D Stimulates the peptidyltransferase activity of the 70S ribosome and enhances dipeptide synthesis with N-formylmethionyl-tRNA and puromycin in vitro, suggesting its involvement in the formation of the first peptide bond of a protein; elongation factor P 2307373..2308200 Escherichia coli HS 5595230 YP_001458972.1 CDS EcHS_A2310 NC_009800.1 2308423 2309889 D identified by match to protein family HMM PF01232; match to protein family HMM PF08125; mannitol dehydrogenase 2308423..2309889 Escherichia coli HS 5595231 YP_001458973.1 CDS EcHS_A2311 NC_009800.1 2310007 2310993 D yeiR; identified by match to protein family HMM PF02492; match to protein family HMM PF07683; CobW/P47K family protein 2310007..2310993 Escherichia coli HS 5595232 YP_001458974.1 CDS EcHS_A2312 NC_009800.1 2311032 2311745 D identified by match to protein family HMM PF01569; PAP2 family protein 2311032..2311745 Escherichia coli HS 5594366 YP_001458975.1 CDS spr NC_009800.1 2312157 2312723 D by similarity, Spr seems to have peptidase activity; involved in thermoresistance; outer membrane lipoprotein 2312157..2312723 Escherichia coli HS 5594367 YP_001458976.1 CDS EcHS_A2314 NC_009800.1 2312904 2314460 D rtn; identified by similarity to SP:P76446; match to protein family HMM PF00563; hypothetical protein 2312904..2314460 Escherichia coli HS 5594368 YP_001458977.1 CDS EcHS_A2315 NC_009800.1 2314542 2316356 D identified by match to protein family HMM PF00496; ABC transporter peripllasmic solute-binding proteins 2314542..2316356 Escherichia coli HS 5594745 YP_001458978.1 CDS EcHS_A2316 NC_009800.1 2316357 2317451 D identified by match to protein family HMM PF00528; ABC transporter permease 2316357..2317451 Escherichia coli HS 5594746 YP_001458979.1 CDS EcHS_A2317 NC_009800.1 2317451 2318476 D identified by match to protein family HMM PF00528; ABC transporter permease 2317451..2318476 Escherichia coli HS 5594747 YP_001458980.1 CDS EcHS_A2318 NC_009800.1 2318478 2320067 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 2318478..2320067 Escherichia coli HS 5595374 YP_001458981.1 CDS EcHS_A2319 NC_009800.1 2320071 2320415 R yejG; identified by similarity to SP:P0AD23; hypothetical protein complement(2320071..2320415) Escherichia coli HS 5595375 YP_001458982.1 CDS bcr NC_009800.1 2320748 2321938 R Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance; bicyclomycin/multidrug efflux system complement(2320748..2321938) Escherichia coli HS 5595376 YP_001458983.1 CDS rsuA NC_009800.1 2321966 2322661 R catalyzes the synthesis pseudouridine from uracil-516 in 16S ribosomal RNA; 16S rRNA pseudouridylate synthase A complement(2321966..2322661) Escherichia coli HS 5595342 YP_001458984.1 CDS EcHS_A2322 NC_009800.1 2322810 2324570 D identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF04851; helicase 2322810..2324570 Escherichia coli HS 5595343 YP_001458985.1 CDS rplY NC_009800.1 2324695 2324979 D the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 2324695..2324979 Escherichia coli HS 5595344 YP_001458986.1 CDS ndpA NC_009800.1 2325118 2326125 R identified by similarity to SP:P33920; match to protein family HMM PF04245; nucleoid-associated protein NdpA complement(2325118..2326125) Escherichia coli HS 5592147 YP_001458987.1 CDS EcHS_A2325 NC_009800.1 2326170 2326289 R identified by glimmer; hypothetical protein complement(2326170..2326289) Escherichia coli HS 5592148 YP_001458988.1 CDS EcHS_A2326 NC_009800.1 2326307 2326534 D yejL; identified by match to protein family HMM PF07208; hypothetical protein 2326307..2326534 Escherichia coli HS 5592149 YP_001458989.1 CDS EcHS_A2327 NC_009800.1 2326554 2328314 D identified by match to protein family HMM PF00884; sulfatase 2326554..2328314 Escherichia coli HS 5592008 YP_001458990.1 CDS EcHS_A2329 NC_009800.1 2328568 2331159 R identified by match to protein family HMM PF03212; match to protein family HMM PF03797; match to protein family HMM TIGR01414; autotransporter IS5K-containing complement(2328568..2331159) Escherichia coli HS 5592010 YP_001458991.1 CDS EcHS_A2330 NC_009800.1 2331275 2331370 D identified by glimmer; hypothetical protein 2331275..2331370 Escherichia coli HS 5594258 YP_001458992.1 CDS narP NC_009800.1 2331479 2332126 D nitrate/nitrite response regulator NarP; NarP is phosphorylated by NarX and NarQ and can activate fdnG and nitrite or nitrate reductase systems; represses expression of other anaerobic genes; transcriptional regulator NarP 2331479..2332126 Escherichia coli HS 5594259 YP_001458993.1 CDS EcHS_A2332 NC_009800.1 2332337 2333389 R identified by match to protein family HMM PF03918; cytochrome c-type biogenesis family protein complement(2332337..2333389) Escherichia coli HS 5591289 YP_001458994.1 CDS dsbE NC_009800.1 2333386 2333943 R identified by similarity to SP:P0AA86; match to protein family HMM PF00578; match to protein family HMM PF08534; match to protein family HMM TIGR00385; thiol:disulfide interchange protein DsbE complement(2333386..2333943) Escherichia coli HS 5591290 YP_001458995.1 CDS ccmF NC_009800.1 2333940 2335883 R identified by match to protein family HMM PF01578; match to protein family HMM TIGR00353; cytochrome c-type biogenesis protein CcmF complement(2333940..2335883) Escherichia coli HS 5591291 YP_001458996.1 CDS ccmE NC_009800.1 2335880 2336359 R CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane; cytochrome c-type biogenesis protein CcmE complement(2335880..2336359) Escherichia coli HS 5591751 YP_001458997.1 CDS ccmD NC_009800.1 2336356 2336565 R identified by match to protein family HMM PF04995; match to protein family HMM TIGR03141; heme exporter protein D complement(2336356..2336565) Escherichia coli HS 5591752 YP_001458998.1 CDS ccmC NC_009800.1 2336562 2337299 R identified by match to protein family HMM PF01578; match to protein family HMM TIGR01191; heme exporter protein C complement(2336562..2337299) Escherichia coli HS 5591753 YP_001458999.1 CDS ccmB NC_009800.1 2337341 2338003 R identified by match to protein family HMM PF03379; match to protein family HMM TIGR01190; heme exporter protein CcmB complement(2337341..2338003) Escherichia coli HS 5594082 YP_001459000.1 CDS ccmA NC_009800.1 2338000 2338617 R ATP-binding protein; required for proper cytochrome c maturation; cytochrome c biogenesis protein CcmA complement(2338000..2338617) Escherichia coli HS 5594083 YP_001459001.1 CDS napC NC_009800.1 2338636 2339238 R with NapABDFGH functions as a nitrate reductase; NapC functions as an electron shuttle between NapAB and NapGH or quinone; cytochrome c-type protein NapC complement(2338636..2339238) Escherichia coli HS 5594084 YP_001459002.1 CDS napB NC_009800.1 2339248 2339697 R small subunit of periplasmic nitrate reductase; receives electrons from the membrane-bound NapC and passes them to NapA; citrate reductase cytochrome c-type subunit complement(2339248..2339697) Escherichia coli HS 5594764 YP_001459003.1 CDS napH NC_009800.1 2339694 2340557 R part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; quinol dehydrogenase membrane component complement(2339694..2340557) Escherichia coli HS 5594765 YP_001459004.1 CDS napG NC_009800.1 2340544 2341239 R part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway; quinol dehydrogenase periplasmic component complement(2340544..2341239) Escherichia coli HS 5594766 YP_001459005.1 CDS napA NC_009800.1 2341246 2343732 R periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC; nitrate reductase catalytic subunit complement(2341246..2343732) Escherichia coli HS 5592269 YP_001459006.1 CDS napD NC_009800.1 2343729 2343992 R napD; identified by match to protein family HMM PF03927; assembly protein for periplasmic nitrate reductase complement(2343729..2343992) Escherichia coli HS 5592270 YP_001459007.1 CDS napF NC_009800.1 2343982 2344476 R Predicted role in electron transfer to the periplasmic nitrate reductase NapA.; ferredoxin-type protein complement(2343982..2344476) Escherichia coli HS 5592271 YP_001459008.1 CDS eco NC_009800.1 2344884 2345372 D identified by match to protein family HMM PF03974; ecotin 2344884..2345372 Escherichia coli HS 5591827 YP_001459009.1 CDS EcHS_A2348 NC_009800.1 2345884 2346099 R identified by glimmer; hypothetical protein complement(2345884..2346099) Escherichia coli HS 5591828 YP_001459010.1 CDS mqo NC_009800.1 2346089 2347735 R malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; malate:quinone oxidoreductase complement(2346089..2347735) Escherichia coli HS 5591829 YP_001459011.1 CDS EcHS_A2350 NC_009800.1 2347953 2349596 R efflux pump for the antibacterial peptide microcin J25; multidrug transporter membrane component/ATP-binding component complement(2347953..2349596) Escherichia coli HS 5590976 YP_001459012.1 CDS alkB NC_009800.1 2349672 2350322 R identified by similarity to SP:P05050; match to protein family HMM PF03171; match to protein family HMM TIGR00568; alkylated DNA repair protein AlkB complement(2349672..2350322) Escherichia coli HS 5590977 YP_001459013.1 CDS ada NC_009800.1 2350322 2351386 R identified by similarity to SP:P06134; match to protein family HMM PF00165; match to protein family HMM PF01035; match to protein family HMM PF02805; match to protein family HMM PF02870; match to protein family HMM TIGR00589; regulatory protein Ada complement(2350322..2351386) Escherichia coli HS 5590978 YP_001459014.1 CDS apbE NC_009800.1 2351460 2352515 R catalyzes the conversion of aminoimidazole ribotide to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine moiety of thiamine; involved in the maintenance and/or assembly of sulfur clusters; periplasmic lipoporotein anchored to the inner membrane; part of the thiamine pyrophosphate biosynthesis pathway; thiamine biosynthesis lipoprotein ApbE complement(2351460..2352515) Escherichia coli HS 5593769 YP_001459015.1 CDS ompC NC_009800.1 2352627 2353733 R allows for ions and hydrophilic solutes to cross the outer membrane; outer membrane porin protein C complement(2352627..2353733) Escherichia coli HS 5593770 YP_001459016.1 CDS EcHS_A2355 NC_009800.1 2354169 2354261 R identified by glimmer; hypothetical protein complement(2354169..2354261) Escherichia coli HS 5591897 YP_001459017.1 CDS yojN NC_009800.1 2354470 2357142 D identified by similarity to SP:P39838; match to protein family HMM PF01627; match to protein family HMM PF02518; phosphotransfer intermediate protein in two-component regulatory system with RcsBC 2354470..2357142 Escherichia coli HS 5591898 YP_001459018.1 CDS rcsB NC_009800.1 2357123 2357809 D two-component response regulator RscB regulates the genes involved in capsule biosynthesis and cell division; probably phosphorylated by RcsC or RcsF; transcriptional regulator RcsB 2357123..2357809 Escherichia coli HS 5591899 YP_001459019.1 CDS EcHS_A2358 NC_009800.1 2357806 2357907 R identified by glimmer; hypothetical protein complement(2357806..2357907) Escherichia coli HS 5593130 YP_001459020.1 CDS rcsC NC_009800.1 2358009 2360858 R identified by similarity to SP:P14376; match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF02518; hybrid sensory kinase in two-component regulatory system with RcsB and YojN complement(2358009..2360858) Escherichia coli HS 5593131 YP_001459021.1 CDS atoS NC_009800.1 2361025 2362851 D with AtoC is a member of a two-component regulatory system involved in the transcriptional regulation of the ato genes for acetoacetate metabolism; sensory histidine kinase AtoS 2361025..2362851 Escherichia coli HS 5593132 YP_001459022.1 CDS atoC NC_009800.1 2362848 2364233 D with AtoS is a two-component regulatory system involved in the transcriptional regulation of the ato genes for acetoacetate metabolism; acetoacetate metabolism regulatory protein AtoC 2362848..2364233 Escherichia coli HS 5593133 YP_001459023.1 CDS pcaI NC_009800.1 2364429 2365091 D identified by similarity to SP:Q01103; match to protein family HMM PF01144; match to protein family HMM TIGR02429; acetyl-CoA:acetoacetyl-CoA transferase subunit alpha 2364429..2365091 Escherichia coli HS 5594279 YP_001459024.1 CDS EcHS_A2363 NC_009800.1 2365091 2365741 D identified by match to protein family HMM PF01144; match to protein family HMM TIGR02428; 3-oxoacid CoA-transferase subunit B 2365091..2365741 Escherichia coli HS 5594280 YP_001459025.1 CDS EcHS_A2364 NC_009800.1 2365738 2367060 D identified by match to protein family HMM PF02667; match to protein family HMM TIGR00366; short chain fatty acid transporter 2365738..2367060 Escherichia coli HS 5594281 YP_001459026.1 CDS atoB NC_009800.1 2367091 2368275 D identified by similarity to SP:P76461; match to protein family HMM PF00108; match to protein family HMM PF02803; match to protein family HMM TIGR01930; acetyl-CoA acetyltransferase 2367091..2368275 Escherichia coli HS 5594439 YP_001459027.1 CDS EcHS_A2366 NC_009800.1 2368349 2369125 R yfaP; identified by similarity to GB:ABA76735.1; hypothetical protein complement(2368349..2369125) Escherichia coli HS 5594440 YP_001459028.1 CDS EcHS_A2367 NC_009800.1 2369130 2370779 R yfaQ; identified by similarity to GB:AAZ88932.1; hypothetical protein complement(2369130..2370779) Escherichia coli HS 5594441 YP_001459029.1 CDS EcHS_A2368 NC_009800.1 2370780 2375294 R identified by match to protein family HMM PF01835; match to protein family HMM PF07703; alpha-2-macroglobulin complement(2370780..2375294) Escherichia coli HS 5594535 YP_001459030.2 CDS EcHS_A2369 NC_009800.1 2375318 2375941 R yfaT; identified by match to protein family HMM PF06672; hypothetical protein complement(2375318..2375941) Escherichia coli HS 5594536 YP_001459031.1 CDS EcHS_A2370 NC_009800.1 2375938 2377626 R yfaA; identified by similarity to SP:P17994; hypothetical protein complement(2375938..2377626) Escherichia coli HS 5594537 YP_001459032.1 CDS gyrA NC_009800.1 2377775 2380402 R negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A complement(2377775..2380402) Escherichia coli HS 5592445 YP_001459033.1 CDS ubiG NC_009800.1 2380549 2381271 D Involved in ubiquinone biosynthesis; 3-demethylubiquinone-9 3-methyltransferase 2380549..2381271 Escherichia coli HS 5592446 YP_001459034.1 CDS EcHS_A2373 NC_009800.1 2381399 2385151 R yfaL; identified by match to protein family HMM PF02415; match to protein family HMM PF03212; match to protein family HMM PF03797; match to protein family HMM TIGR01376; match to protein family HMM TIGR01414; match to protein family HMM TIGR02601; adhesin complement(2381399..2385151) Escherichia coli HS 5592447 YP_001459035.1 CDS nrdA NC_009800.1 2385847 2388132 D Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 2385847..2388132 Escherichia coli HS 5594027 YP_001459036.1 CDS nrdB NC_009800.1 2388366 2389496 D B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA; ribonucleotide-diphosphate reductase subunit beta 2388366..2389496 Escherichia coli HS 5594028 YP_001459037.1 CDS EcHS_A2376 NC_009800.1 2389496 2389750 D plays a role in maintenance and possibly the biosynthesis of diferric-tyrosyl radical cofactor, essential for nucleotide reduction catalyzed by ribonucleotide reductases; 2Fe-2S ferredoxin 2389496..2389750 Escherichia coli HS 5594029 YP_001459038.1 CDS EcHS_A2377 NC_009800.1 2389804 2390454 R identified by similarity to SP:P27294; match to protein family HMM PF06293; hypothetical protein complement(2389804..2390454) Escherichia coli HS 5595517 YP_001459039.1 CDS EcHS_A2378 NC_009800.1 2390669 2390875 D yfaH; hypothetical protein 2390669..2390875 Escherichia coli HS 5595518 YP_001459040.1 CDS glpQ NC_009800.1 2390917 2391993 R hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic; glycerophosphodiester phosphodiesterase complement(2390917..2391993) Escherichia coli HS 5595519 YP_001459041.1 CDS glpT NC_009800.1 2391998 2393356 R catalyzes the uptake of glycerol-3-phosphate into the cell with the simultaneous export of inorganic phosphate from the cell; sn-glycerol-3-phosphate transporter complement(2391998..2393356) Escherichia coli HS 5591037 YP_001459042.1 CDS EcHS_A2381 NC_009800.1 2393473 2393604 D identified by glimmer; hypothetical protein 2393473..2393604 Escherichia coli HS 5591038 YP_001459043.1 CDS glpA NC_009800.1 2393629 2395257 D anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor; sn-glycerol-3-phosphate dehydrogenase subunit A 2393629..2395257 Escherichia coli HS 5591039 YP_001459044.1 CDS glpB NC_009800.1 2395247 2396506 D sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters; anaerobic glycerol-3-phosphate dehydrogenase subunit B 2395247..2396506 Escherichia coli HS 5591520 YP_001459045.1 CDS glpC NC_009800.1 2396503 2397693 D anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate; sn-glycerol-3-phosphate dehydrogenase subunit C 2396503..2397693 Escherichia coli HS 5591521 YP_001459046.1 CDS EcHS_A2385 NC_009800.1 2397718 2397843 D identified by glimmer; hypothetical protein 2397718..2397843 Escherichia coli HS 5591522 YP_001459047.1 CDS EcHS_A2386 NC_009800.1 2397886 2398788 D yfaD; identified by match to protein family HMM PF04754; match to protein family HMM TIGR01784; hypothetical protein 2397886..2398788 Escherichia coli HS 5591857 YP_001459048.1 CDS EcHS_A2387 NC_009800.1 2398829 2399632 R identified by match to protein family HMM PF03328; aldolase complement(2398829..2399632) Escherichia coli HS 5591858 YP_001459049.1 CDS EcHS_A2388 NC_009800.1 2399650 2400939 R identified by match to protein family HMM PF07690; major facilitator transporter complement(2399650..2400939) Escherichia coli HS 5591859 YP_001459050.1 CDS EcHS_A2389 NC_009800.1 2400996 2402213 R identified by match to protein family HMM PF01188; match to protein family HMM PF02746; mandelate racemase/muconate lactonizing enzyme family protein complement(2400996..2402213) Escherichia coli HS 5592442 YP_001459051.1 CDS EcHS_A2390 NC_009800.1 2402216 2402998 R identified by match to protein family HMM PF01614; match to protein family HMM PF09339; IclR family transcriptional regulator complement(2402216..2402998) Escherichia coli HS 5592443 YP_001459052.1 CDS EcHS_A2391 NC_009800.1 2403013 2403108 R identified by glimmer; hypothetical protein complement(2403013..2403108) Escherichia coli HS 5592444 YP_001459053.1 CDS EcHS_A2392 NC_009800.1 2403218 2404420 R identified by match to protein family HMM PF00994; match to protein family HMM TIGR00177; match to protein family HMM TIGR00200; competence damage-inducible protein A complement(2403218..2404420) Escherichia coli HS 5593065 YP_001459054.1 CDS EcHS_A2395 NC_009800.1 2405183 2405284 R identified by glimmer; hypothetical protein complement(2405183..2405284) Escherichia coli HS 5593067 YP_001459055.1 CDS EcHS_A2396 NC_009800.1 2405341 2405766 D identified by match to protein family HMM PF00293; NUDIX family hydrolase 2405341..2405766 Escherichia coli HS 5592435 YP_001459056.1 CDS EcHS_A2397 NC_009800.1 2405805 2406407 R identified by match to protein family HMM PF00300; phosphoglycerate mutase complement(2405805..2406407) Escherichia coli HS 5592436 YP_001459057.1 CDS arnB NC_009800.1 2406715 2407854 D catalyzes the conversion of UDP-4-keto-arabinose to UDP-4-amino-4-deoxy-L-arabinose; UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase 2406715..2407854 Escherichia coli HS 5592437 YP_001459058.1 CDS arnC NC_009800.1 2407858 2408826 D catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate; undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase 2407858..2408826 Escherichia coli HS 5592530 YP_001459059.1 CDS arnA NC_009800.1 2408826 2410808 D Bifunctional polymyxin resistance arnA protein; catalyzes the decarboxylation of UDP-glucuronic acid to UDP-4-keto-arabinose and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose to form UDP-L-4-formamido-arabinose; active in certain mutant strains; bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase 2408826..2410808 Escherichia coli HS 5592531 YP_001459060.1 CDS EcHS_A2401 NC_009800.1 2410805 2411695 D identified by match to protein family HMM PF01522; polysaccharide deacetylase 2410805..2411695 Escherichia coli HS 5592532 YP_001459061.1 CDS arnT NC_009800.1 2411695 2413347 D catalyzes the addition of 4-amino-4-deoxy-L-arabinose to lipid A; 4-amino-4-deoxy-L-arabinose transferase 2411695..2413347 Escherichia coli HS 5594470 YP_001459062.1 CDS EcHS_A2403 NC_009800.1 2413344 2413679 D NULL; identified by match to protein family HMM PF00893; SMR family multidrug efflux pump 2413344..2413679 Escherichia coli HS 5594471 YP_001459063.1 CDS EcHS_A2404 NC_009800.1 2413679 2414065 D hypothetical protein 2413679..2414065 Escherichia coli HS 5594472 YP_001459064.1 CDS pmrD NC_009800.1 2414059 2414325 R NULL; identified by similarity to SP:P37590; polymyxin B resistance protein pmrD complement(2414059..2414325) Escherichia coli HS 5594621 YP_001459065.1 CDS menE NC_009800.1 2414435 2415790 R identified by match to protein family HMM PF00501; match to protein family HMM TIGR01923; O-succinylbenzoic acid--CoA ligase complement(2414435..2415790) Escherichia coli HS 5594622 YP_001459066.1 CDS menC NC_009800.1 2415787 2416749 R catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase complement(2415787..2416749) Escherichia coli HS 5594623 YP_001459067.1 CDS menB NC_009800.1 2416749 2417606 R catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase complement(2416749..2417606) Escherichia coli HS 5594861 YP_001459068.1 CDS EcHS_A2409 NC_009800.1 2417621 2418379 R catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; acyl-CoA thioester hydrolase complement(2417621..2418379) Escherichia coli HS 5594862 YP_001459069.1 CDS menD NC_009800.1 2418376 2420046 R SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase complement(2418376..2420046) Escherichia coli HS 5594863 YP_001459070.1 CDS menF NC_009800.1 2420135 2421430 R identified by similarity to SP:P38051; match to protein family HMM PF00425; match to protein family HMM TIGR00543; menaquinone-specific isochorismate synthase complement(2420135..2421430) Escherichia coli HS 5594423 YP_001459071.1 CDS EcHS_A2412 NC_009800.1 2421509 2421814 R elaB; identified by similarity to GB:CAG75914.1; hypothetical protein complement(2421509..2421814) Escherichia coli HS 5594424 YP_001459072.1 CDS EcHS_A2413 NC_009800.1 2421869 2422330 R elaA; identified by match to protein family HMM PF00583; hypothetical protein complement(2421869..2422330) Escherichia coli HS 5594425 YP_001459073.1 CDS rnz NC_009800.1 2422395 2423312 D member of metallo-beta-lactamase; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 2422395..2423312 Escherichia coli HS 5595307 YP_001459074.1 CDS EcHS_A2416 NC_009800.1 2423764 2424267 R identified by match to protein family HMM PF03400; IS1, transposase orfB complement(2423764..2424267) Escherichia coli HS 5595309 YP_001459075.1 CDS EcHS_A2417 NC_009800.1 2424186 2424461 R identified by match to protein family HMM PF03811; IS1, transposase orfA complement(2424186..2424461) Escherichia coli HS 5594770 YP_001459076.1 CDS EcHS_A2419 NC_009800.1 2425566 2427293 R identified by match to protein family HMM PF00092; von Willebrand factor A complement(2425566..2427293) Escherichia coli HS 5594772 YP_001459077.1 CDS EcHS_A2420 NC_009800.1 2427431 2428402 D identified by match to protein family HMM PF04389; M28A family peptidase 2427431..2428402 Escherichia coli HS 5594213 YP_001459078.1 CDS EcHS_A2421 NC_009800.1 2428505 2429008 D yfbM; identified by similarity to SP:P76483; match to protein family HMM PF08974; hypothetical protein 2428505..2429008 Escherichia coli HS 5594214 YP_001459079.1 CDS EcHS_A2422 NC_009800.1 2429281 2429997 R yfbN; identified by glimmer; hypothetical protein complement(2429281..2429997) Escherichia coli HS 5594215 YP_001459080.1 CDS EcHS_A2423 NC_009800.1 2430152 2430628 D identified by glimmer; hypothetical protein 2430152..2430628 Escherichia coli HS 5593144 YP_001459081.1 CDS EcHS_A2424 NC_009800.1 2430687 2431535 D identified by glimmer; hypothetical protein 2430687..2431535 Escherichia coli HS 5593145 YP_001459082.1 CDS nuoN NC_009800.1 2431619 2433076 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit N complement(2431619..2433076) Escherichia coli HS 5593146 YP_001459083.1 CDS nuoM NC_009800.1 2433083 2434612 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit M complement(2433083..2434612) Escherichia coli HS 5592424 YP_001459084.1 CDS nuoL NC_009800.1 2434776 2436617 R Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit L complement(2434776..2436617) Escherichia coli HS 5592425 YP_001459085.1 CDS nuoK NC_009800.1 2436614 2436916 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit K complement(2436614..2436916) Escherichia coli HS 5592426 YP_001459086.1 CDS nuoJ NC_009800.1 2436913 2437467 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit J complement(2436913..2437467) Escherichia coli HS 5592313 YP_001459087.1 CDS nuoI NC_009800.1 2437479 2438021 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I complement(2437479..2438021) Escherichia coli HS 5592314 YP_001459088.1 CDS nuoH NC_009800.1 2438036 2439013 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit H complement(2438036..2439013) Escherichia coli HS 5592315 YP_001459089.1 CDS nuoG NC_009800.1 2439010 2441736 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit G complement(2439010..2441736) Escherichia coli HS 5592077 YP_001459090.1 CDS nuoF NC_009800.1 2441789 2443126 R shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase; NADH dehydrogenase I subunit F complement(2441789..2443126) Escherichia coli HS 5592078 YP_001459091.1 CDS nuoE NC_009800.1 2443123 2443623 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit E complement(2443123..2443623) Escherichia coli HS 5592079 YP_001459092.1 CDS nuoC NC_009800.1 2443626 2445428 R NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms; bifunctional NADH:ubiquinone oxidoreductase subunit C/D complement(2443626..2445428) Escherichia coli HS 5591052 YP_001459093.1 CDS nuoB NC_009800.1 2445522 2446184 R The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B complement(2445522..2446184) Escherichia coli HS 5591053 YP_001459094.1 CDS nuoA NC_009800.1 2446200 2446643 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit A complement(2446200..2446643) Escherichia coli HS 5591054 YP_001459095.1 CDS lrhA NC_009800.1 2447274 2448212 R identified by similarity to SP:P36771; match to protein family HMM PF00126; match to protein family HMM PF03466; transcriptional regulator LrhA complement(2447274..2448212) Escherichia coli HS 5592365 YP_001459096.1 CDS EcHS_A2439 NC_009800.1 2449132 2450349 D broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase 2449132..2450349 Escherichia coli HS 5592366 YP_001459097.1 CDS yfbR NC_009800.1 2450433 2451032 D identified by similarity to SP:P76491; match to protein family HMM PF01966; hypothetical protein 2450433..2451032 Escherichia coli HS 5592367 YP_001459098.1 CDS EcHS_A2441 NC_009800.1 2451091 2452923 R identified by match to protein family HMM PF02080; match to protein family HMM PF03600; match to protein family HMM PF06808; transporter complement(2451091..2452923) Escherichia coli HS 5591779 YP_001459099.1 CDS yfbT NC_009800.1 2453010 2453660 R identified by similarity to SP:P77625; match to protein family HMM PF00702; match to protein family HMM TIGR01509; match to protein family HMM TIGR01549; phosphatase complement(2453010..2453660) Escherichia coli HS 5591780 YP_001459100.1 CDS EcHS_A2444 NC_009800.1 2454248 2454703 R identified by match to protein family HMM PF04217; hypothetical protein complement(2454248..2454703) Escherichia coli HS 5591975 YP_001459101.1 CDS EcHS_A2445 NC_009800.1 2454772 2454903 R identified by similarity to GB:AAN81291.1; hypothetical protein complement(2454772..2454903) Escherichia coli HS 5591976 YP_001459102.1 CDS ackA NC_009800.1 2455041 2456243 D AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 2455041..2456243 Escherichia coli HS 5591977 YP_001459103.1 CDS pta1 NC_009800.1 2456318 2458462 D catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 2456318..2458462 Escherichia coli HS 5593264 YP_001459104.1 CDS EcHS_A2448 NC_009800.1 2458631 2460172 D identified by match to protein family HMM PF03606; hypothetical protein 2458631..2460172 Escherichia coli HS 5593265 YP_001459105.1 CDS EcHS_A2449 NC_009800.1 2460205 2460747 R identified by match to protein family HMM PF00293; NUDIX family hydrolase complement(2460205..2460747) Escherichia coli HS 5593266 YP_001459106.1 CDS EcHS_A2450 NC_009800.1 2460805 2461356 R identified by similarity to SP:P67095; match to protein family HMM PF00149; match to protein family HMM TIGR00040; phosphodiesterase complement(2460805..2461356) Escherichia coli HS 5592507 YP_001459107.1 CDS EcHS_A2451 NC_009800.1 2461412 2462056 R identified by similarity to SP:P77544; match to protein family HMM PF02798; glutathione S-transferase domain-containing protein complement(2461412..2462056) Escherichia coli HS 5592508 YP_001459108.1 CDS EcHS_A2452 NC_009800.1 2462192 2462839 D identified by match to protein family HMM PF00043; match to protein family HMM PF02798; glutathione S-transferase 2462192..2462839 Escherichia coli HS 5592509 YP_001459109.1 CDS folX NC_009800.1 2462896 2463258 D catalyzes the formation of dihydromonapterin triphosphate from dihydroneopterin triphosphate; D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase 2462896..2463258 Escherichia coli HS 5591283 YP_001459110.1 CDS EcHS_A2454 NC_009800.1 2463279 2464172 D identified by match to protein family HMM PF01370; match to protein family HMM PF07993; match to protein family HMM PF08338; match to protein family HMM TIGR01777; NAD-binding domain-containing protein 2463279..2464172 Escherichia coli HS 5591284 YP_001459111.1 CDS hisP NC_009800.1 2465307 2466080 R identified by match to protein family HMM PF00005; histidine/lysine/arginine/ornithine transporter subunit complement(2465307..2466080) Escherichia coli HS 5593383 YP_001459112.1 CDS hisM NC_009800.1 2466088 2466804 R identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; histidine ABC transporter permease HisM complement(2466088..2466804) Escherichia coli HS 5593384 YP_001459113.1 CDS hisQ NC_009800.1 2466801 2467487 R identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; histidine ABC transporter permease HisQ complement(2466801..2467487) Escherichia coli HS 5593385 YP_001459114.1 CDS hisJ NC_009800.1 2467577 2468359 R identified by match to protein family HMM PF00497; match to protein family HMM TIGR01096; histidine ABC transporter periplasmic histidine-binding protein complement(2467577..2468359) Escherichia coli HS 5594094 YP_001459115.1 CDS argT NC_009800.1 2468580 2469362 R identified by similarity to SP:P09551; match to protein family HMM PF00497; match to protein family HMM TIGR01096; lysine-arginine-ornithine-binding periplasmic protein complement(2468580..2469362) Escherichia coli HS 5594095 YP_001459116.1 CDS EcHS_A2461 NC_009800.1 2469483 2469650 R identified by similarity to GB:AAX66263.1; hypothetical protein complement(2469483..2469650) Escherichia coli HS 5594096 YP_001459117.1 CDS ubiX NC_009800.1 2469628 2470197 R catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase complement(2469628..2470197) Escherichia coli HS 5593807 YP_001459118.1 CDS purF NC_009800.1 2470292 2471809 R Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase complement(2470292..2471809) Escherichia coli HS 5593808 YP_001459119.1 CDS cvpA NC_009800.1 2471846 2472334 R membrane protein required for colicin V production; colicin V production protein complement(2471846..2472334) Escherichia coli HS 5593809 YP_001459120.1 CDS EcHS_A2465 NC_009800.1 2472593 2473255 R identified by match to protein family HMM PF05036; hypothetical protein complement(2472593..2473255) Escherichia coli HS 5592414 YP_001459121.1 CDS folC NC_009800.1 2473245 2474513 R identified by match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; bifunctional folylpolyglutamate synthase/ dihydrofolate synthase complement(2473245..2474513) Escherichia coli HS 5592415 YP_001459122.1 CDS accD NC_009800.1 2474583 2475497 R catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta complement(2474583..2475497) Escherichia coli HS 5592416 YP_001459123.1 CDS EcHS_A2468 NC_009800.1 2475653 2476312 R identified by similarity to SP:P0ABP6; match to protein family HMM PF09335; hypothetical protein complement(2475653..2476312) Escherichia coli HS 5591024 YP_001459124.1 CDS truA NC_009800.1 2476395 2477207 R mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A complement(2476395..2477207) Escherichia coli HS 5591025 YP_001459125.1 CDS EcHS_A2470 NC_009800.1 2477207 2478220 R identified by similarity to SP:P08390; match to protein family HMM PF01118; match to protein family HMM PF02774; semialdehyde dehydrogenase complement(2477207..2478220) Escherichia coli HS 5591026 YP_001459126.1 CDS pdxB NC_009800.1 2478286 2479422 R identified by similarity to SP:P05459; match to protein family HMM PF00389; match to protein family HMM PF02826; erythronate-4-phosphate dehydrogenase complement(2478286..2479422) Escherichia coli HS 5590970 YP_001459127.1 CDS flk NC_009800.1 2479521 2480516 D in Salmonella typhimurium Flk regulates flagellar biosynthesis by inhibition of the flagellar-associated type III secretion system; lowers secretion levels of the anti-sigma28 factor FlgM to the periplasm; inner membrane-anchored protein; flagella biosynthesis regulator 2479521..2480516 Escherichia coli HS 5590971 YP_001459128.1 CDS EcHS_A2473 NC_009800.1 2480513 2481691 R identified by match to protein family HMM PF07690; hypothetical protein complement(2480513..2481691) Escherichia coli HS 5590972 YP_001459129.1 CDS fabB NC_009800.1 2481956 2483176 R FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase complement(2481956..2483176) Escherichia coli HS 5592869 YP_001459130.1 CDS mnmC NC_009800.1 2483335 2485341 D catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules; 5-methylaminomethyl-2-thiouridine methyltransferase 2483335..2485341 Escherichia coli HS 5592870 YP_001459131.1 CDS EcHS_A2476 NC_009800.1 2485328 2485441 R identified by glimmer; hypothetical protein complement(2485328..2485441) Escherichia coli HS 5592871 YP_001459132.1 CDS EcHS_A2477 NC_009800.1 2485462 2485740 R yfcL; identified by similarity to GB:ABB66925.1; match to protein family HMM PF08891; hypothetical protein complement(2485462..2485740) Escherichia coli HS 5592032 YP_001459133.1 CDS EcHS_A2478 NC_009800.1 2485774 2486322 R identified by match to protein family HMM PF04315; hypothetical protein complement(2485774..2486322) Escherichia coli HS 5592033 YP_001459134.1 CDS EcHS_A2479 NC_009800.1 2486322 2487131 R identified by match to protein family HMM PF01925; hypothetical protein complement(2486322..2487131) Escherichia coli HS 5592034 YP_001459135.1 CDS mepA NC_009800.1 2487131 2487955 R D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm; penicillin-insensitive murein endopeptidase complement(2487131..2487955) Escherichia coli HS 5592681 YP_001459136.1 CDS aroC NC_009800.1 2487959 2489044 R catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase complement(2487959..2489044) Escherichia coli HS 5592682 YP_001459137.1 CDS prmB NC_009800.1 2489079 2490011 R involved in methylation of ribosomal protein L3; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase complement(2489079..2490011) Escherichia coli HS 5592683 YP_001459138.1 CDS EcHS_A2483 NC_009800.1 2490177 2490728 D identified by match to protein family HMM PF01713; hypothetical protein 2490177..2490728 Escherichia coli HS 5593593 YP_001459139.1 CDS EcHS_A2484 NC_009800.1 2490800 2491657 R hypothetical protein complement(2490800..2491657) Escherichia coli HS 5593594 YP_001459140.1 CDS EcHS_A2485 NC_009800.1 2491659 2492198 R identified by match to protein family HMM PF00419; fimbrial protein complement(2491659..2492198) Escherichia coli HS 5593595 YP_001459141.1 CDS EcHS_A2486 NC_009800.1 2492195 2492683 R identified by similarity to GB:AAV78666.1; hypothetical protein complement(2492195..2492683) Escherichia coli HS 5593692 YP_001459142.1 CDS EcHS_A2487 NC_009800.1 2492680 2493189 R identified by similarity to GB:AAV76235.1; minor fimbrial subunit complement(2492680..2493189) Escherichia coli HS 5593693 YP_001459143.1 CDS EcHS_A2488 NC_009800.1 2493205 2493957 R identified by match to protein family HMM PF00345; periplasmic pilus chaperone family protein complement(2493205..2493957) Escherichia coli HS 5593694 YP_001459144.1 CDS EcHS_A2489 NC_009800.1 2493977 2496619 R identified by match to protein family HMM PF00577; fimbrial usher family protein complement(2493977..2496619) Escherichia coli HS 5593695 YP_001459145.1 CDS EcHS_A2490 NC_009800.1 2496701 2497264 R identified by similarity to GB:AAC64152.1; match to protein family HMM PF00419; fimbrial protein complement(2496701..2497264) Escherichia coli HS 5593696 YP_001459146.1 CDS sixA NC_009800.1 2497948 2498433 R identified by match to protein family HMM PF00300; match to protein family HMM TIGR00249; phosphohistidine phosphatase complement(2497948..2498433) Escherichia coli HS 5593697 YP_001459147.1 CDS fadJ NC_009800.1 2498636 2500780 R multifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities: forms a heterotetramer with FadI; similar to FadA2B2 complex; involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate; multifunctional fatty acid oxidation complex subunit alpha complement(2498636..2500780) Escherichia coli HS 5594960 YP_001459148.1 CDS fadI NC_009800.1 2500780 2502090 R FadI; fatty acid oxidation complex component beta; functions in a heterotetramer with FadJ; similar to FadA2B2 complex; functions in beta-oxidation of fatty acids during anaerobic growth; 3-ketoacyl-CoA thiolase complement(2500780..2502090) Escherichia coli HS 5594961 YP_001459149.1 CDS EcHS_A2494 NC_009800.1 2502270 2502554 R yfcZ; identified by match to protein family HMM PF04175; match to protein family HMM TIGR00743; hypothetical protein complement(2502270..2502554) Escherichia coli HS 5594962 YP_001459150.1 CDS EcHS_A2495 NC_009800.1 2502926 2504266 D identified by match to protein family HMM PF03349; long-chain fatty acid outer membrane transporter 2502926..2504266 Escherichia coli HS 5593087 YP_001459151.1 CDS EcHS_A2496 NC_009800.1 2504632 2505690 D identified by similarity to GB:AAP17747.1; hypothetical protein 2504632..2505690 Escherichia coli HS 5593088 YP_001459152.1 CDS EcHS_A2497 NC_009800.1 2505872 2506627 R identified by match to protein family HMM PF04333; VacJ family lipoprotein complement(2505872..2506627) Escherichia coli HS 5593089 YP_001459153.1 CDS EcHS_A2498 NC_009800.1 2506653 2506823 R identified by similarity to GB:AAN81341.1; hypothetical protein complement(2506653..2506823) Escherichia coli HS 5592307 YP_001459154.1 CDS EcHS_A2499 NC_009800.1 2506921 2507853 D hypothetical protein 2506921..2507853 Escherichia coli HS 5592308 YP_001459155.1 CDS dsdC NC_009800.1 2508099 2509034 R regulates the synthesis and expression of the dsdXA operon and dadA gene; DNA-binding transcriptional regulator DsdC complement(2508099..2509034) Escherichia coli HS 5593195 YP_001459156.1 CDS EcHS_A2502 NC_009800.1 2509252 2510589 D member of the Gnt family of gluconate transporters; not involved in gluconate transport; unknown function; permease DsdX 2509252..2510589 Escherichia coli HS 5593196 YP_001459157.1 CDS dsdA NC_009800.1 2510607 2511935 D catalyzes the formation of pyruvate from serine; D-serine dehydratase 2510607..2511935 Escherichia coli HS 5594825 YP_001459158.1 CDS emrY NC_009800.1 2512043 2513581 R identified by similarity to SP:P52600; match to protein family HMM PF07690; match to protein family HMM TIGR00711; multidrug resistance protein Y complement(2512043..2513581) Escherichia coli HS 5594826 YP_001459159.1 CDS emrK NC_009800.1 2513581 2514744 R identified by similarity to SP:P52599; match to protein family HMM PF00529; match to protein family HMM TIGR00998; drug resistance MFS transporter membrane fusion protein (MFP) subunit EmrK complement(2513581..2514744) Escherichia coli HS 5594827 YP_001459160.1 CDS evgA NC_009800.1 2515160 2515774 D response regulator in two-component regulatory system with EvgS; phosphorylated EvgA activates ompC, emrKY, gadABC, hdeAB and others genes; involved in acid resistance, osmotic adaption, and drug resistance; DNA-binding transcriptional activator EvgA 2515160..2515774 Escherichia coli HS 5591923 YP_001459161.1 CDS evgS NC_009800.1 2515779 2519372 D identified by similarity to SP:P30855; match to protein family HMM PF00072; match to protein family HMM PF00497; match to protein family HMM PF00512; match to protein family HMM PF01627; match to protein family HMM PF02518; hybrid sensory histidine kinase in two-component regulatory system with EvgA 2515779..2519372 Escherichia coli HS 5591924 YP_001459162.1 CDS EcHS_A2508 NC_009800.1 2519428 2520573 R identified by match to protein family HMM PF02515; hypothetical protein complement(2519428..2520573) Escherichia coli HS 5591925 YP_001459163.1 CDS EcHS_A2509 NC_009800.1 2520647 2521591 R member of the AEC family of auxin efflux transporters; unknown function; transporter YfdV complement(2520647..2521591) Escherichia coli HS 5592501 YP_001459164.1 CDS EcHS_A2510 NC_009800.1 2521661 2523355 R catalyzes the formation of formyl-CoA from oxalyl-CoA; oxalyl-CoA decarboxylase complement(2521661..2523355) Escherichia coli HS 5592502 YP_001459165.1 CDS frc NC_009800.1 2523409 2524659 R catalyzes the formation of oxalyl-CoA from oxalate and Formyl-CoA; formyl-coenzyme A transferase complement(2523409..2524659) Escherichia coli HS 5592503 YP_001459166.1 CDS EcHS_A2512 NC_009800.1 2525172 2525804 R yfdX; identified by similarity to SP:P76520; hypothetical protein complement(2525172..2525804) Escherichia coli HS 5591875 YP_001459167.1 CDS EcHS_A2513 NC_009800.1 2526452 2526694 R yfdY; identified by similarity to GB:AAV76465.1; hypothetical protein complement(2526452..2526694) Escherichia coli HS 5591876 YP_001459168.1 CDS EcHS_A2514 NC_009800.1 2527047 2527967 D Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(palmitoleoyl)-lipid IVA in cells subjected to cold shock; lipid A biosynthesis palmitoleoyl acyltransferase 2527047..2527967 Escherichia coli HS 5591877 YP_001459169.1 CDS EcHS_A2515 NC_009800.1 2528278 2528394 D identified by glimmer; hypothetical protein 2528278..2528394 Escherichia coli HS 5594913 YP_001459170.1 CDS EcHS_A2516 NC_009800.1 2528459 2529697 R identified by match to protein family HMM PF00155; aminotransferase complement(2528459..2529697) Escherichia coli HS 5594914 YP_001459171.1 CDS EcHS_A2517 NC_009800.1 2530091 2531770 D identified by match to protein family HMM PF01590; match to protein family HMM PF02518; match to protein family HMM PF06580; match to protein family HMM PF07694; sensor histidine kinase 2530091..2531770 Escherichia coli HS 5594915 YP_001459172.1 CDS EcHS_A2518 NC_009800.1 2531785 2532519 D identified by match to protein family HMM PF00072; match to protein family HMM PF04397; response regulator 2531785..2532519 Escherichia coli HS 5591403 YP_001459173.1 CDS EcHS_A2519 NC_009800.1 2532532 2533389 D identified by match to protein family HMM PF00165; AraC family transcriptional regulator 2532532..2533389 Escherichia coli HS 5591404 YP_001459174.1 CDS fryA NC_009800.1 2533392 2535887 R identified by match to protein family HMM PF00359; match to protein family HMM PF00381; match to protein family HMM PF00391; match to protein family HMM PF02896; match to protein family HMM PF05524; match to protein family HMM TIGR00848; match to protein family HMM TIGR01417; multiphosphoryl transfer protein 1 complement(2533392..2535887) Escherichia coli HS 5591405 YP_001459175.1 CDS EcHS_A2521 NC_009800.1 2535912 2536949 R metalloprotein; exoaminopeptidase complement(2535912..2536949) Escherichia coli HS 5591249 YP_001459176.1 CDS ypdF NC_009800.1 2536949 2538034 R Xaa-Pro aminopeptidase; limited methionine aminopeptidase; aminopeptidase complement(2536949..2538034) Escherichia coli HS 5591250 YP_001459177.1 CDS fryC NC_009800.1 2538049 2539296 R identified by match to protein family HMM PF02378; match to protein family HMM TIGR01427; PTS system, fructose-like, IIC component complement(2538049..2539296) Escherichia coli HS 5591251 YP_001459178.1 CDS EcHS_A2524 NC_009800.1 2539318 2539644 R identified by match to protein family HMM PF02379; match to protein family HMM TIGR00829; PTS system, fructose specific IIB subunit complement(2539318..2539644) Escherichia coli HS 5594396 YP_001459179.1 CDS glk NC_009800.1 2539863 2540828 R catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate; glucokinase complement(2539863..2540828) Escherichia coli HS 5594397 YP_001459180.1 CDS EcHS_A2526 NC_009800.1 2541032 2542288 D yfeO; hypothetical protein 2541032..2542288 Escherichia coli HS 5594398 YP_001459183.1 CDS mntH NC_009800.1 2542870 2544108 R identified by match to protein family HMM PF01566; match to protein family HMM TIGR01197; manganese transport protein MntH complement(2542870..2544108) Escherichia coli HS 5593080 YP_001459184.1 CDS nupC NC_009800.1 2544444 2545646 D identified by similarity to SP:P33031; match to protein family HMM PF01773; match to protein family HMM PF07662; match to protein family HMM PF07670; match to protein family HMM TIGR00804; nucleoside transporter NupC 2544444..2545646 Escherichia coli HS 5593480 YP_001459185.1 CDS EcHS_A2531 NC_009800.1 2545849 2546961 R identified by match to protein family HMM PF01609; IS186, transposase complement(2545849..2546961) Escherichia coli HS 5593481 YP_001459186.1 CDS EcHS_A2532 NC_009800.1 2547045 2549234 R identified by match to protein family HMM PF00563; match to protein family HMM PF00990; match to protein family HMM PF05231; diguanylate cyclase complement(2547045..2549234) Escherichia coli HS 5593482 YP_001459187.1 CDS EcHS_A2535 NC_009800.1 2549869 2550213 D yfeC; hypothetical protein 2549869..2550213 Escherichia coli HS 5592541 YP_001459188.1 CDS EcHS_A2536 NC_009800.1 2550215 2550607 D yfeD; identified by match to protein family HMM PF07037; hypothetical protein 2550215..2550607 Escherichia coli HS 5592542 YP_001459189.1 CDS gltX NC_009800.1 2550659 2552074 R Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase complement(2550659..2552074) Escherichia coli HS 5594442 YP_001459190.1 CDS EcHS_A2542 NC_009800.1 2553162 2553503 D identified by glimmer; hypothetical protein 2553162..2553503 Escherichia coli HS 5591411 YP_001459191.1 CDS EcHS_A2543 NC_009800.1 2553494 2554420 R identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator complement(2553494..2554420) Escherichia coli HS 5595116 YP_001459192.1 CDS EcHS_A2544 NC_009800.1 2554510 2555508 D identified by match to protein family HMM PF01758; bile acid/Na+ symporter family protein 2554510..2555508 Escherichia coli HS 5595117 YP_001459193.1 CDS EcHS_A2545 NC_009800.1 2555505 2555723 R identified by similarity to SP:P0AD40; hypothetical protein complement(2555505..2555723) Escherichia coli HS 5593255 YP_001459194.1 CDS ligA NC_009800.1 2555725 2557740 R this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA complement(2555725..2557740) Escherichia coli HS 5593256 YP_001459195.1 CDS zipA NC_009800.1 2557811 2558797 R interacts with cell division protein FitsZ and may be required to anchor septal ring structure; cell division protein ZipA complement(2557811..2558797) Escherichia coli HS 5593257 YP_001459196.1 CDS cysZ NC_009800.1 2559027 2559788 D role in sulfur assimilation; sulfate transport protein CysZ 2559027..2559788 Escherichia coli HS 5593817 YP_001459197.1 CDS cysK NC_009800.1 2559973 2560944 D CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis; cysteine synthase A 2559973..2560944 Escherichia coli HS 5593818 YP_001459198.1 CDS ptsH NC_009800.1 2561328 2561585 D identified by match to protein family HMM PF00381; match to protein family HMM TIGR01003; phosphohistidinoprotein-hexose phosphotransferase component of PTS system (Hpr) 2561328..2561585 Escherichia coli HS 5593819 YP_001459199.1 CDS ptsI NC_009800.1 2561630 2563357 D Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system; phosphoenolpyruvate-protein phosphotransferase 2561630..2563357 Escherichia coli HS 5594175 YP_001459200.1 CDS crr NC_009800.1 2563398 2563907 D functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose; glucose-specific PTS system component 2563398..2563907 Escherichia coli HS 5594176 YP_001459201.1 CDS pdxK NC_009800.1 2563950 2564801 R catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxal kinase complement(2563950..2564801) Escherichia coli HS 5594177 YP_001459202.1 CDS EcHS_A2554 NC_009800.1 2564906 2565280 D yfeK; identified by similarity to SP:Q47702; hypothetical protein 2564906..2565280 Escherichia coli HS 5595418 YP_001459203.1 CDS EcHS_A2555 NC_009800.1 2565313 2566047 D identified by match to protein family HMM PF05406; WGR domain-containing protein 2565313..2566047 Escherichia coli HS 5595419 YP_001459205.1 CDS cysM NC_009800.1 2566236 2567147 R catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide; cysteine synthase B complement(2566236..2567147) Escherichia coli HS 5594244 YP_001459206.1 CDS cysA NC_009800.1 2567281 2568378 R identified by match to protein family HMM PF00005; match to protein family HMM TIGR00968; sulfate/thiosulfate transporter subunit complement(2567281..2568378) Escherichia coli HS 5594245 YP_001459207.1 CDS cysW NC_009800.1 2568368 2569243 R Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import; sulfate/thiosulfate transporter permease subunit complement(2568368..2569243) Escherichia coli HS 5594246 YP_001459208.1 CDS cysT NC_009800.1 2569243 2570076 R identified by similarity to SP:P16701; match to protein family HMM PF00528; match to protein family HMM TIGR00969; match to protein family HMM TIGR02139; sulfate/thiosulfate transporter subunit complement(2569243..2570076) Escherichia coli HS 5593450 YP_001459209.1 CDS cysP NC_009800.1 2570076 2571092 R identified by match to protein family HMM PF01547; match to protein family HMM TIGR00971; thiosulfate transporter subunit complement(2570076..2571092) Escherichia coli HS 5593451 YP_001459210.1 CDS ucpA NC_009800.1 2571250 2572041 R identified by similarity to SP:P37440; match to protein family HMM PF00106; match to protein family HMM PF01370; match to protein family HMM PF08659; short chain dehydrogenase complement(2571250..2572041) Escherichia coli HS 5593452 YP_001459211.1 CDS EcHS_A2563 NC_009800.1 2572170 2573027 R yfeT; identified by match to protein family HMM PF01380; match to protein family HMM PF01418; RpiR family transcriptional regulator complement(2572170..2573027) Escherichia coli HS 5594270 YP_001459212.1 CDS murQ NC_009800.1 2573191 2574087 D catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway; N-acetylmuramic acid-6-phosphate etherase 2573191..2574087 Escherichia coli HS 5594271 YP_001459213.1 CDS murP NC_009800.1 2574091 2575515 D belongs to PEP-dependent PTS system; contains the PTS EIIBC domains; involved in uptake of exogenous N-acetylmuramic acid (MurNAc); requires crr-encoded enzyme IIA-glucose component; N-acetylmuramic acid phosphotransfer permease 2574091..2575515 Escherichia coli HS 5594272 YP_001459214.1 CDS EcHS_A2566 NC_009800.1 2575520 2576824 D identified by match to protein family HMM PF00144; hypothetical protein 2575520..2576824 Escherichia coli HS 5593216 YP_001459215.1 CDS EcHS_A2567 NC_009800.1 2577102 2578082 D identified by match to protein family HMM PF01548; match to protein family HMM PF02371; IS621, transposase 2577102..2578082 Escherichia coli HS 5593217 YP_001459216.1 CDS EcHS_A2568 NC_009800.1 2578343 2579242 R identified by match to protein family HMM PF04261; match to protein family HMM TIGR01413; dyp-type peroxidase complement(2578343..2579242) Escherichia coli HS 5593218 YP_001459217.1 CDS EcHS_A2569 NC_009800.1 2579338 2579913 R identified by match to protein family HMM PF06572; hypothetical protein complement(2579338..2579913) Escherichia coli HS 5595250 YP_001459218.1 CDS EcHS_A2570 NC_009800.1 2579974 2580423 R inner membrane protein YfeZ complement(2579974..2580423) Escherichia coli HS 5595251 YP_001459219.1 CDS EcHS_A2571 NC_009800.1 2580410 2580835 R identified by match to protein family HMM PF00583; acetyltransferase complement(2580410..2580835) Escherichia coli HS 5595252 YP_001459220.1 CDS amiA NC_009800.1 2581049 2581918 D identified by similarity to SP:P36548; match to protein family HMM PF01520; match to protein family HMM TIGR01409; N-acetylmuramoyl-L-alanine amidase 2581049..2581918 Escherichia coli HS 5592295 YP_001459221.1 CDS hemF NC_009800.1 2581922 2582821 D catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis; coproporphyrinogen III oxidase 2581922..2582821 Escherichia coli HS 5592296 YP_001459222.1 CDS EcHS_A2574 NC_009800.1 2582827 2583879 R activates the transcription of the ethanolamine utilization operon; transcriptional regulator EutR complement(2582827..2583879) Escherichia coli HS 5592297 YP_001459223.1 CDS EcHS_A2575 NC_009800.1 2583925 2584425 R identified by similarity to SP:Q9ZFU8; match to protein family HMM PF00936; ethanolamine utilization protein EutK complement(2583925..2584425) Escherichia coli HS 5593084 YP_001459224.1 CDS EcHS_A2576 NC_009800.1 2584438 2585097 R identified by similarity to SP:P0A1C9; match to protein family HMM PF00936; ethanolamine utilization protein EutL complement(2584438..2585097) Escherichia coli HS 5593085 YP_001459225.1 CDS eutC NC_009800.1 2585107 2585994 R catalyzes the formation of acetaldehyde from ethanolamine; ethanolamine ammonia-lyase small subunit complement(2585107..2585994) Escherichia coli HS 5593086 YP_001459226.1 CDS eutB NC_009800.1 2586015 2587376 R identified by similarity to SP:P19264; match to protein family HMM PF06751; ethanolamine ammonia-lyase, large subunit complement(2586015..2587376) Escherichia coli HS 5592573 YP_001459227.1 CDS eutA NC_009800.1 2587388 2588791 R ethanolamine utilization protein EutA; reactivating factor for ethanolamine ammonia lyase complement(2587388..2588791) Escherichia coli HS 5592574 YP_001459228.1 CDS eutH NC_009800.1 2588788 2590014 R identified by similarity to SP:P41796; match to protein family HMM PF04346; ethanolamine utilization protein EutH complement(2588788..2590014) Escherichia coli HS 5592575 YP_001459229.1 CDS EcHS_A2581 NC_009800.1 2590030 2590230 R identified by glimmer; hypothetical protein complement(2590030..2590230) Escherichia coli HS 5592634 YP_001459230.1 CDS eutG NC_009800.1 2590231 2591418 R identified by similarity to SP:P41795; match to protein family HMM PF00465; ethanolamine utilization protein EutG complement(2590231..2591418) Escherichia coli HS 5592635 YP_001459231.1 CDS eutJ NC_009800.1 2591408 2592244 R identified by similarity to SP:P0A206; match to protein family HMM TIGR02529; ethanolamine utilization protein EutJ complement(2591408..2592244) Escherichia coli HS 5592636 YP_001459232.1 CDS eutE NC_009800.1 2592255 2593658 R identified by similarity to SP:P41793; match to protein family HMM PF00171; ethanolamine utilization protein EutE complement(2592255..2593658) Escherichia coli HS 5591891 YP_001459233.1 CDS eutN NC_009800.1 2593670 2593957 R identified by similarity to SP:P41792; match to protein family HMM PF03319; ethanolamine utilization protein complement(2593670..2593957) Escherichia coli HS 5591892 YP_001459234.1 CDS eutM NC_009800.1 2594064 2594357 R identified by match to protein family HMM PF00936; ethanolamine utilization protein EutM complement(2594064..2594357) Escherichia coli HS 5591893 YP_001459235.1 CDS eutD NC_009800.1 2594396 2595412 R in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; phosphotransacetylase complement(2594396..2595412) Escherichia coli HS 5590893 YP_001459236.1 CDS eutT NC_009800.1 2595409 2596212 R eutT; identified by similarity to SP:Q9ZFV4; match to protein family HMM PF01923; ethanolamine utilization cobalamin adenosyltransferase complement(2595409..2596212) Escherichia coli HS 5590894 YP_001459237.1 CDS EcHS_A2589 NC_009800.1 2596209 2596910 R identified by match to protein family HMM PF05899; match to protein family HMM PF06249; ethanolamine utilization protein EutQ complement(2596209..2596910) Escherichia coli HS 5590895 YP_001459238.1 CDS eutP NC_009800.1 2596885 2597364 R eutP; identified by similarity to SP:P0A208; match to protein family HMM TIGR02528; ethanolamine utilization protein, EutP complement(2596885..2597364) Escherichia coli HS 5591480 YP_001459239.1 CDS EcHS_A2591 NC_009800.1 2597377 2597784 R ypfE; identified by similarity to SP:Q9ZFV7; match to protein family HMM PF00936; ethanolamine utilization protein EutS complement(2597377..2597784) Escherichia coli HS 5591481 YP_001459240.1 CDS maeB NC_009800.1 2598005 2600284 R NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; malic enzyme complement(2598005..2600284) Escherichia coli HS 5591482 YP_001459241.1 CDS tal1 NC_009800.1 2600573 2601523 D identified by match to protein family HMM PF00923; match to protein family HMM TIGR00874; transaldolase A 2600573..2601523 Escherichia coli HS 5595511 YP_001459242.1 CDS tktB NC_009800.1 2601543 2603546 D catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 2601543..2603546 Escherichia coli HS 5595512 YP_001459243.1 CDS EcHS_A2595 NC_009800.1 2603641 2604684 R ypfG; identified by similarity to GB:ABB67033.1; match to protein family HMM PF06674; hypothetical protein complement(2603641..2604684) Escherichia coli HS 5595513 YP_001459244.1 CDS EcHS_A2596 NC_009800.1 2604810 2605385 R yffH; identified by match to protein family HMM PF00293; match to protein family HMM TIGR00052; NUDIX family hydrolase complement(2604810..2605385) Escherichia coli HS 5595155 YP_001459245.1 CDS aegA1 NC_009800.1 2605453 2607432 R unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic); oxidoreductase Fe-S binding subunit complement(2605453..2607432) Escherichia coli HS 5595156 YP_001459246.1 CDS narQ NC_009800.1 2607638 2609338 D identified by similarity to SP:P27896; match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM PF07730; nitrate/nitrite sensor protein NarQ 2607638..2609338 Escherichia coli HS 5595157 YP_001459247.1 CDS acrD NC_009800.1 2609502 2612615 D identified by similarity to SP:P24177; match to protein family HMM PF00873; match to protein family HMM TIGR00915; aminoglycoside/multidrug efflux system 2609502..2612615 Escherichia coli HS 5591188 YP_001459248.1 CDS EcHS_A2600 NC_009800.1 2613032 2613133 R identified by glimmer; hypothetical protein complement(2613032..2613133) Escherichia coli HS 5591189 YP_001459249.1 CDS EcHS_A2601 NC_009800.1 2613154 2613510 D yffB; identified by match to protein family HMM PF03960; match to protein family HMM TIGR01617; hypothetical protein 2613154..2613510 Escherichia coli HS 5591190 YP_001459250.1 CDS dapE NC_009800.1 2613514 2614641 D dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.; succinyl-diaminopimelate desuccinylase 2613514..2614641 Escherichia coli HS 5590991 YP_001459251.1 CDS EcHS_A2603 NC_009800.1 2614669 2614869 D identified by similarity to GB:AAN81450.1; hypothetical protein 2614669..2614869 Escherichia coli HS 5590992 YP_001459252.1 CDS EcHS_A2604 NC_009800.1 2614979 2615677 R Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase complement(2614979..2615677) Escherichia coli HS 5590993 YP_001459253.1 CDS EcHS_A2605 NC_009800.1 2615751 2617766 R ypfI; identified by similarity to GB:ABB67041.1; match to protein family HMM PF05127; hypothetical protein complement(2615751..2617766) Escherichia coli HS 5591136 YP_001459254.1 CDS EcHS_A2606 NC_009800.1 2617781 2618644 R identified by match to protein family HMM PF04228; hypothetical protein complement(2617781..2618644) Escherichia coli HS 5591137 YP_001459255.1 CDS purC NC_009800.1 2618812 2619525 R catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase complement(2618812..2619525) Escherichia coli HS 5591138 YP_001459256.1 CDS EcHS_A2608 NC_009800.1 2619531 2619638 R identified by similarity to GB:CAA27854.1; hypothetical protein complement(2619531..2619638) Escherichia coli HS 5590919 YP_001459257.1 CDS EcHS_A2609 NC_009800.1 2619738 2620772 R identified by match to protein family HMM PF06804; lipoprotein complement(2619738..2620772) Escherichia coli HS 5590920 YP_001459258.1 CDS dapA NC_009800.1 2620789 2621667 R catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase complement(2620789..2621667) Escherichia coli HS 5590921 YP_001459259.1 CDS gcvR NC_009800.1 2621747 2622385 D negative transcriptional regulator of the gcvTHP operon; glycine cleavage system transcriptional repressor 2621747..2622385 Escherichia coli HS 5591146 YP_001459260.1 CDS bcp NC_009800.1 2622385 2622855 D bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine; thioredoxin-dependent thiol peroxidase 2622385..2622855 Escherichia coli HS 5591147 YP_001459261.1 CDS hyfA NC_009800.1 2623108 2623725 D identified by match to protein family HMM PF00037; hydrogenase-4 component A 2623108..2623725 Escherichia coli HS 5591148 YP_001459262.1 CDS hyfC NC_009800.1 2625753 2626700 D identified by similarity to SP:P16430; similarity to SP:P77858; match to protein family HMM PF00146; hydrogenase-4 component C 2625753..2626700 Escherichia coli HS 5590965 YP_001459263.1 CDS hyfE NC_009800.1 2628205 2628855 D interacts with formate dehydrogenase to produce an active formate hydrogenlyase complex which cleaves formate to dihydrogen and carbon dioxide; hydrogenase 4 membrane subunit 2628205..2628855 Escherichia coli HS 5591062 YP_001459264.1 CDS EcHS_A2620 NC_009800.1 2628860 2630440 D identified by similarity to SP:P77437; match to protein family HMM PF00361; hydrogenase 4 subunit F 2628860..2630440 Escherichia coli HS 5591063 YP_001459265.1 CDS EcHS_A2621 NC_009800.1 2630430 2632097 D identified by similarity to SP:P77329; match to protein family HMM PF00329; match to protein family HMM PF00346; hydrogenase-4, G subunit 2630430..2632097 Escherichia coli HS 5591064 YP_001459266.1 CDS EcHS_A2622 NC_009800.1 2632107 2632646 D probable electron transfer protein for hydrogenase 4; hydrogenase 4 is believed to be silent in E. coli under conditions tested so far; hydrogenase 4 subunit H 2632107..2632646 Escherichia coli HS 5590884 YP_001459267.1 CDS EcHS_A2623 NC_009800.1 2632643 2633401 D identified by similarity to SP:P77668; match to protein family HMM PF01058; hydrogenase-4, I subunit 2632643..2633401 Escherichia coli HS 5590885 YP_001459268.1 CDS EcHS_A2624 NC_009800.1 2633394 2633807 D identified by match to protein family HMM PF07450; formate hydrogenlyase maturation protein HycH 2633394..2633807 Escherichia coli HS 5590886 YP_001459269.1 CDS EcHS_A2625 NC_009800.1 2633903 2635849 D identified by similarity to SP:P19323; match to protein family HMM PF00158; match to protein family HMM PF01590; match to protein family HMM PF02954; formate hydrogenlyase transcriptional activator 2633903..2635849 Escherichia coli HS 5590985 YP_001459270.1 CDS focB NC_009800.1 2635871 2636719 D inner membrane protein presumed to act as a formate transporter; member of the hyf operon; formate transporter 2635871..2636719 Escherichia coli HS 5590986 YP_001459271.1 CDS EcHS_A2627 NC_009800.1 2636757 2637818 R identified by match to protein family HMM PF01594; PerM family permease complement(2636757..2637818) Escherichia coli HS 5590987 YP_001459272.1 CDS EcHS_A2628 NC_009800.1 2638031 2639494 D identified by match to protein family HMM PF01435; M48 family peptidase 2638031..2639494 Escherichia coli HS 5590903 YP_001459273.1 CDS arsC1 NC_009800.1 2639515 2639874 D identified by match to protein family HMM PF03960; match to protein family HMM TIGR00014; arsenate reductase 2639515..2639874 Escherichia coli HS 5590904 YP_001459274.1 CDS EcHS_A2630 NC_009800.1 2639889 2639999 R identified by glimmer; hypothetical protein complement(2639889..2639999) Escherichia coli HS 5590905 YP_001459275.1 CDS hda NC_009800.1 2640012 2640758 R controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP; DNA replication initiation factor complement(2640012..2640758) Escherichia coli HS 5590890 YP_001459276.1 CDS uraA NC_009800.1 2640808 2642097 R identified by match to protein family HMM PF00860; match to protein family HMM TIGR00801; uracil transporter complement(2640808..2642097) Escherichia coli HS 5590891 YP_001459277.1 CDS upp NC_009800.1 2642183 2642809 R Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase complement(2642183..2642809) Escherichia coli HS 5590892 YP_001459278.1 CDS purM NC_009800.1 2643134 2644171 D catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 2643134..2644171 Escherichia coli HS 5591027 YP_001459279.1 CDS purN NC_009800.1 2644171 2644809 D glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 2644171..2644809 Escherichia coli HS 5591028 YP_001459280.1 CDS ppk NC_009800.1 2644979 2647045 D catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase 2644979..2647045 Escherichia coli HS 5591029 YP_001459281.1 CDS ppx NC_009800.1 2647050 2648591 D identified by similarity to SP:P29014; match to protein family HMM PF02541; exopolyphosphatase 2647050..2648591 Escherichia coli HS 5592304 YP_001459282.1 CDS EcHS_A2640 NC_009800.1 2651055 2651207 R identified by similarity to GB:AAG57614.1; hypothetical protein complement(2651055..2651207) Escherichia coli HS 5592306 YP_001459283.1 CDS EcHS_A2641 NC_009800.1 2651225 2651416 D yfgG; identified by similarity to GB:AAL21400.1; hypothetical protein 2651225..2651416 Escherichia coli HS 5591012 YP_001459284.1 CDS EcHS_A2642 NC_009800.1 2651730 2652245 D identified by match to protein family HMM PF05433; surface antigen family protein 2651730..2652245 Escherichia coli HS 5591013 YP_001459285.1 CDS EcHS_A2643 NC_009800.1 2652261 2652800 D identified by similarity to SP:P76573; hypothetical protein 2652261..2652800 Escherichia coli HS 5591014 YP_001459286.1 CDS EcHS_A2644 NC_009800.1 2653015 2657112 R identified by match to protein family HMM PF01381; match to protein family HMM TIGR02607; addiction module complement(2653015..2657112) Escherichia coli HS 5591972 YP_001459287.1 CDS EcHS_A2645 NC_009800.1 2657275 2658282 R identified by glimmer; hypothetical protein complement(2657275..2658282) Escherichia coli HS 5591973 YP_001459288.1 CDS trbL NC_009800.1 2658945 2660336 R identified by match to protein family HMM PF04610; match to protein family HMM TIGR02783; P-type conjugative transfer protein TrbL complement(2658945..2660336) Escherichia coli HS 5591974 YP_001459289.1 CDS trbJ NC_009800.1 2660524 2661318 R identified by match to protein family HMM TIGR02780; conjugal transfer protein TrbJ complement(2660524..2661318) Escherichia coli HS 5591848 YP_001459290.1 CDS EcHS_A2648 NC_009800.1 2661400 2662044 R hypothetical protein complement(2661400..2662044) Escherichia coli HS 5591849 YP_001459291.1 CDS EcHS_A2649 NC_009800.1 2662757 2663032 D identified by match to protein family HMM PF03811; IS1, transposase orfA 2662757..2663032 Escherichia coli HS 5591850 YP_001459292.1 CDS EcHS_A2650 NC_009800.1 2662951 2663454 D identified by match to protein family HMM PF03400; IS1, transposase orfB 2662951..2663454 Escherichia coli HS 5591938 YP_001459293.1 CDS EcHS_A2651 NC_009800.1 2663465 2664313 R identified by match to protein family HMM PF04796; plasmid encoded RepA protein complement(2663465..2664313) Escherichia coli HS 5591939 YP_001459294.1 CDS EcHS_A2652 NC_009800.1 2664383 2664613 R identified by match to protein family HMM PF05930; AlpA family transcriptional regulator complement(2664383..2664613) Escherichia coli HS 5591940 YP_001459295.1 CDS EcHS_A2653 NC_009800.1 2664820 2666160 D identified by glimmer; hypothetical protein 2664820..2666160 Escherichia coli HS 5591508 YP_001459296.1 CDS EcHS_A2654 NC_009800.1 2666253 2666528 D identified by match to protein family HMM PF03811; IS1, transposase orfA 2666253..2666528 Escherichia coli HS 5591509 YP_001459297.1 CDS EcHS_A2655 NC_009800.1 2666447 2666950 D identified by match to protein family HMM PF03400; IS1, transposase orfB 2666447..2666950 Escherichia coli HS 5591510 YP_001459298.1 CDS EcHS_A2656 NC_009800.1 2667104 2668291 R identified by match to protein family HMM PF00589; phage integrase site specific recombinase complement(2667104..2668291) Escherichia coli HS 5591888 YP_001459299.1 CDS EcHS_A2657 NC_009800.1 2668354 2668518 R identified by glimmer; hypothetical protein complement(2668354..2668518) Escherichia coli HS 5591889 YP_001459300.1 CDS guaA NC_009800.1 2668598 2670175 R contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase complement(2668598..2670175) Escherichia coli HS 5591890 YP_001459301.1 CDS guaB NC_009800.1 2670244 2671710 R catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase complement(2670244..2671710) Escherichia coli HS 5594971 YP_001459302.1 CDS xseA NC_009800.1 2671872 2673242 D bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 2671872..2673242 Escherichia coli HS 5594972 YP_001459303.1 CDS EcHS_A2661 NC_009800.1 2673239 2673454 R yfgJ; identified by similarity to GB:ABB62753.1; match to protein family HMM PF07191; hypothetical protein complement(2673239..2673454) Escherichia coli HS 5594973 YP_001459304.1 CDS engA NC_009800.1 2673523 2674995 R EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA complement(2673523..2674995) Escherichia coli HS 5591603 YP_001459305.1 CDS EcHS_A2663 NC_009800.1 2675113 2676291 R with YaeT, YfiO, and NlpB forms a complex involved in outer membrane protein biogenesis; outer membrane protein assembly complex subunit YfgL complement(2675113..2676291) Escherichia coli HS 5591604 YP_001459306.1 CDS EcHS_A2664 NC_009800.1 2676302 2676922 R yfgM; identified by similarity to GB:AAP83327.1; hypothetical protein complement(2676302..2676922) Escherichia coli HS 5591605 YP_001459307.1 CDS hisS NC_009800.1 2676940 2678214 R catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase complement(2676940..2678214) Escherichia coli HS 5591667 YP_001459308.1 CDS ispG NC_009800.1 2678325 2679443 R catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase complement(2678325..2679443) Escherichia coli HS 5591669 YP_001459309.1 CDS EcHS_A2667 NC_009800.1 2679470 2680483 R identified by match to protein family HMM PF01381; hypothetical protein complement(2679470..2680483) Escherichia coli HS 5591630 YP_001459310.1 CDS EcHS_A2668 NC_009800.1 2680768 2681922 R yfgB; identified by match to protein family HMM PF04055; match to protein family HMM TIGR00048; hypothetical protein complement(2680768..2681922) Escherichia coli HS 5591631 YP_001459311.1 CDS ndk NC_009800.1 2682072 2682503 R catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase complement(2682072..2682503) Escherichia coli HS 5591632 YP_001459312.1 CDS pbpC NC_009800.1 2682652 2684964 R penicillin-insensitive transglycosylase/transpeptidase; penicillin-binding protein 1C complement(2682652..2684964) Escherichia coli HS 5594983 YP_001459313.1 CDS EcHS_A2671 NC_009800.1 2684965 2689926 R yfhM; identified by match to protein family HMM PF01835; match to protein family HMM PF07703; alpha-2-macroglobulin complement(2684965..2689926) Escherichia coli HS 5594984 YP_001459314.1 CDS sseA NC_009800.1 2690133 2690978 D catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds; 3-mercaptopyruvate sulfurtransferase 2690133..2690978 Escherichia coli HS 5594985 YP_001459315.1 CDS sseB NC_009800.1 2691796 2692572 R enhances serine sensitivity caused by inhibition of homoserine dehydrogenase I; enhanced serine sensitivity protein SseB complement(2691796..2692572) Escherichia coli HS 5595035 YP_001459316.1 CDS pepB NC_009800.1 2692714 2693997 R catalyzes the removal of an N-terminal amino acid from a peptide or arylamide; aminopeptidase complement(2692714..2693997) Escherichia coli HS 5591590 YP_001459317.1 CDS iscX NC_009800.1 2694055 2694255 R identified by similarity to SP:P0C0L9; match to protein family HMM PF04384; match to protein family HMM TIGR03412; hypothetical protein complement(2694055..2694255) Escherichia coli HS 5591591 YP_001459318.1 CDS fdx NC_009800.1 2694267 2694602 R identified by match to protein family HMM PF00111; match to protein family HMM TIGR02007; (2Fe-2S) ferredoxin complement(2694267..2694602) Escherichia coli HS 5591592 YP_001459319.1 CDS hscA NC_009800.1 2694604 2696454 R involved in the maturation of iron-sulfur cluster-containing proteins; chaperone protein HscA complement(2694604..2696454) Escherichia coli HS 5591483 YP_001459320.1 CDS hscB NC_009800.1 2696471 2696986 R J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins; co-chaperone HscB complement(2696471..2696986) Escherichia coli HS 5591484 YP_001459321.1 CDS iscA NC_009800.1 2697082 2697411 R forms iron-sulfur clusters of ferredoxin [2FE-2S]; binds iron in the presence of the thioredoxin reductase system; forms homodimers and tetramers; similar to SufA protein; iron-sulfur cluster assembly protein complement(2697082..2697411) Escherichia coli HS 5591485 YP_001459322.1 CDS iscU NC_009800.1 2697422 2697808 R identified by match to protein family HMM PF01592; match to protein family HMM TIGR01999; scaffold protein complement(2697422..2697808) Escherichia coli HS 5594696 YP_001459323.1 CDS iscS NC_009800.1 2697836 2699050 R catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis; cysteine desulfurase complement(2697836..2699050) Escherichia coli HS 5594697 YP_001459324.1 CDS iscR NC_009800.1 2699291 2699779 R regulates the expression of the iscRSUA operon; DNA-binding transcriptional regulator IscR complement(2699291..2699779) Escherichia coli HS 5594698 YP_001459325.1 CDS EcHS_A2683 NC_009800.1 2699920 2700126 R identified by glimmer; hypothetical protein complement(2699920..2700126) Escherichia coli HS 5591532 YP_001459326.1 CDS EcHS_A2684 NC_009800.1 2700140 2700880 R identified by match to protein family HMM PF00588; match to protein family HMM TIGR00050; RNA methyltransferase complement(2700140..2700880) Escherichia coli HS 5591533 YP_001459327.1 CDS suhB NC_009800.1 2700999 2701802 D identified by similarity to SP:P0ADG4; match to protein family HMM PF00459; inositol monophosphatase 2700999..2701802 Escherichia coli HS 5591534 YP_001459328.1 CDS EcHS_A2686 NC_009800.1 2701947 2702801 D identified by similarity to SP:P77538; hypothetical protein 2701947..2702801 Escherichia coli HS 5595336 YP_001459329.1 CDS hcaT NC_009800.1 2704264 2705403 R transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters; 3-phenylpropionic acid transporter complement(2704264..2705403) Escherichia coli HS 5595338 YP_001459330.1 CDS hcaR NC_009800.1 2705563 2706453 R activator of 3-phenylpropionic acid catabolism; DNA-binding transcriptional regulator HcaR complement(2705563..2706453) Escherichia coli HS 5595227 YP_001459331.1 CDS hcaE NC_009800.1 2706589 2707950 D identified by similarity to SP:Q47139; match to protein family HMM PF00355; match to protein family HMM PF00848; 3-phenylpropionate dioxygenase alpha subunit 2706589..2707950 Escherichia coli HS 5595228 YP_001459332.1 CDS hcaF NC_009800.1 2707947 2708465 D identified by similarity to SP:Q47140; match to protein family HMM PF00866; 3-phenylpropionate dioxygenase subunit beta 2707947..2708465 Escherichia coli HS 5595229 YP_001459333.1 CDS hcaC NC_009800.1 2708465 2708785 D identified by similarity to SP:P0ABW2; match to protein family HMM PF00355; 3-phenylpropionate dioxygenase ferredoxin subunit 2708465..2708785 Escherichia coli HS 5593574 YP_001459334.1 CDS hcaB NC_009800.1 2708782 2709594 D Converts cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol) into 3-(2,3-dihydroxylphenyl)propionate; 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase 2708782..2709594 Escherichia coli HS 5593575 YP_001459335.1 CDS hcaD NC_009800.1 2709604 2710806 D identified by similarity to SP:P77650; match to protein family HMM PF00070; match to protein family HMM PF07992; phenylpropionate dioxygenase ferredoxin reductase subunit 2709604..2710806 Escherichia coli HS 5593576 YP_001459336.1 CDS EcHS_A2695 NC_009800.1 2710858 2711325 D yphA; identified by match to protein family HMM PF07681; hypothetical protein 2710858..2711325 Escherichia coli HS 5592263 YP_001459337.1 CDS EcHS_A2696 NC_009800.1 2711373 2712245 R identified by match to protein family HMM PF01263; aldose 1-epimerase complement(2711373..2712245) Escherichia coli HS 5592264 YP_001459338.1 CDS EcHS_A2697 NC_009800.1 2712257 2713351 R identified by match to protein family HMM PF00107; match to protein family HMM PF08240; zinc-binding dehydrogenase oxidoreductase complement(2712257..2713351) Escherichia coli HS 5592265 YP_001459339.1 CDS EcHS_A2698 NC_009800.1 2713384 2714382 R yphD; identified by match to protein family HMM PF02653; sugar ABC transporter permease complement(2713384..2714382) Escherichia coli HS 5595288 YP_001459340.1 CDS EcHS_A2699 NC_009800.1 2714407 2715918 R yphE; identified by match to protein family HMM PF00005; sugar ABC transporter ATP-binding protein complement(2714407..2715918) Escherichia coli HS 5595289 YP_001459341.1 CDS EcHS_A2700 NC_009800.1 2715941 2716885 R yphF; identified by match to protein family HMM PF00532; sugar ABC transporter periplasmic sugar-binding protein complement(2715941..2716885) Escherichia coli HS 5595290 YP_001459342.1 CDS EcHS_A2701 NC_009800.1 2716921 2717424 R identified by match to protein family HMM PF03400; IS1, transposase orfB complement(2716921..2717424) Escherichia coli HS 5594776 YP_001459343.1 CDS EcHS_A4685 NC_009800.1 2717343 2717618 R identified by similarity to GB:CAA11401.1; match to protein family HMM PF03811; IS1, transposase orfA complement(2717343..2717618) Escherichia coli HS 5594777 YP_001459344.1 CDS EcHS_A2702 NC_009800.1 2717798 2721172 R identified by match to protein family HMM PF00515; match to protein family HMM PF07719; TPR repeat-containing protein complement(2717798..2721172) Escherichia coli HS 5594778 YP_001459345.1 CDS EcHS_A2703 NC_009800.1 2721197 2722390 D identified by match to protein family HMM PF00480; ROK family protein 2721197..2722390 Escherichia coli HS 5592325 YP_001459346.1 CDS glyA NC_009800.1 2722588 2723841 R catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase complement(2722588..2723841) Escherichia coli HS 5592326 YP_001459347.1 CDS hmp NC_009800.1 2724169 2725359 D flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine; nitric oxide dioxygenase 2724169..2725359 Escherichia coli HS 5592327 YP_001459348.1 CDS glnB NC_009800.1 2725404 2725742 R indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; nitrogen regulatory protein P-II 1 complement(2725404..2725742) Escherichia coli HS 5591966 YP_001459349.1 CDS EcHS_A2707 NC_009800.1 2725803 2727137 R identified by match to protein family HMM PF00072; match to protein family HMM PF00158; match to protein family HMM PF07728; sigma-54 dependent response regulator complement(2725803..2727137) Escherichia coli HS 5591967 YP_001459350.1 CDS EcHS_A2708 NC_009800.1 2727127 2727846 R hypothetical protein complement(2727127..2727846) Escherichia coli HS 5591968 YP_001459351.1 CDS EcHS_A2709 NC_009800.1 2728005 2729432 R identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; sensor histidine kinase complement(2728005..2729432) Escherichia coli HS 5595069 YP_001459352.1 CDS purL NC_009800.1 2729990 2733877 R catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase complement(2729990..2733877) Escherichia coli HS 5595071 YP_001459353.1 CDS EcHS_A2711 NC_009800.1 2734136 2735692 D YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function; transglycosylase 2734136..2735692 Escherichia coli HS 5595444 YP_001459354.1 CDS tadA NC_009800.1 2735689 2736225 R identified by similarity to SP:P68398; match to protein family HMM PF00383; tRNA-specific adenosine deaminase complement(2735689..2736225) Escherichia coli HS 5595445 YP_001459355.1 CDS yhfB NC_009800.1 2736250 2736885 R yfhB; identified by match to protein family HMM TIGR01545; hypothetical protein complement(2736250..2736885) Escherichia coli HS 5595446 YP_001459356.1 CDS EcHS_A2714 NC_009800.1 2737094 2737942 D yfhH; identified by match to protein family HMM PF01380; match to protein family HMM PF01418; DNA-binding transcriptional regulator 2737094..2737942 Escherichia coli HS 5592613 YP_001459357.1 CDS EcHS_A2715 NC_009800.1 2737998 2738258 D yfhL; identified by match to protein family HMM PF00037; 4Fe-4S ferredoxin 2737998..2738258 Escherichia coli HS 5592614 YP_001459358.1 CDS EcHS_A2716 NC_009800.1 2738530 2738682 R NULL; identified by glimmer; hypothetical protein complement(2738530..2738682) Escherichia coli HS 5592615 YP_001459359.1 CDS EcHS_A2717 NC_009800.1 2738732 2738875 R identified by glimmer; hypothetical protein complement(2738732..2738875) Escherichia coli HS 5592516 YP_001459360.1 CDS acpS NC_009800.1 2738954 2739334 R Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase complement(2738954..2739334) Escherichia coli HS 5592517 YP_001459361.1 CDS pdxJ NC_009800.1 2739334 2740065 R involved in the de novo synthesis of pyridoxine (Vitamin B6); pyridoxine 5'-phosphate synthase complement(2739334..2740065) Escherichia coli HS 5592518 YP_001459362.1 CDS recO NC_009800.1 2740077 2740805 R involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO complement(2740077..2740805) Escherichia coli HS 5592589 YP_001459363.1 CDS era NC_009800.1 2740817 2741722 R Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era complement(2740817..2741722) Escherichia coli HS 5592590 YP_001459364.1 CDS rnc NC_009800.1 2741719 2742399 R cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III complement(2741719..2742399) Escherichia coli HS 5592591 YP_001459365.1 CDS lepB NC_009800.1 2742671 2743645 R catalyzes the cleavage of the amino-terminal leader peptide from secretory proteins; signal peptidase I complement(2742671..2743645) Escherichia coli HS 5593386 YP_001459366.1 CDS lepA NC_009800.1 2743661 2745460 R binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA complement(2743661..2745460) Escherichia coli HS 5593387 YP_001459367.1 CDS rseC NC_009800.1 2745658 2746137 R involved in the reduction of the SoxR iron-sulfur cluster; SoxR reducing system protein RseC complement(2745658..2746137) Escherichia coli HS 5593388 YP_001459368.1 CDS rseB NC_009800.1 2746134 2747090 R periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP; periplasmic negative regulator of sigmaE complement(2746134..2747090) Escherichia coli HS 5592260 YP_001459369.1 CDS rseA NC_009800.1 2747090 2747740 R identified by match to protein family HMM PF03872; match to protein family HMM PF03873; anti-RNA polymerase sigma factor SigE complement(2747090..2747740) Escherichia coli HS 5592261 YP_001459370.1 CDS rpoE NC_009800.1 2747773 2748348 R Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE complement(2747773..2748348) Escherichia coli HS 5592262 YP_001459371.1 CDS EcHS_A2729 NC_009800.1 2748561 2748668 R identified by glimmer; hypothetical protein complement(2748561..2748668) Escherichia coli HS 5594599 YP_001459372.1 CDS nadB NC_009800.1 2748756 2750378 D catalyzes the formation of oxaloacetate from L-aspartate; L-aspartate oxidase 2748756..2750378 Escherichia coli HS 5594600 YP_001459373.1 CDS EcHS_A2731 NC_009800.1 2750363 2751100 R identified by match to protein family HMM PF05175; methyltransferase complement(2750363..2751100) Escherichia coli HS 5594601 YP_001459374.1 CDS srmB NC_009800.1 2751232 2752566 D facilitates an early step in the assembly of the 50S subunit of the ribosome; ATP-dependent RNA helicase SrmB 2751232..2752566 Escherichia coli HS 5591007 YP_001459375.1 CDS EcHS_A2733 NC_009800.1 2752837 2753817 D identified by match to protein family HMM PF01548; match to protein family HMM PF02371; IS621, transposase 2752837..2753817 Escherichia coli HS 5591008 YP_001459376.1 CDS EcHS_A2734 NC_009800.1 2754054 2754935 R identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator complement(2754054..2754935) Escherichia coli HS 5591009 YP_001459377.1 CDS EcHS_A2735 NC_009800.1 2755038 2755625 D yfiK; identified by match to protein family HMM PF01810; neutral amino-acid efflux protein 2755038..2755625 Escherichia coli HS 5592764 YP_001459378.1 CDS grcA NC_009800.1 2755681 2756064 R stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit; autonomous glycyl radical cofactor GrcA complement(2755681..2756064) Escherichia coli HS 5592765 YP_001459379.1 CDS ung NC_009800.1 2756369 2757058 D Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 2756369..2757058 Escherichia coli HS 5592766 YP_001459380.1 CDS EcHS_A2739 NC_009800.1 2758350 2758769 D identified by match to protein family HMM PF00085; match to protein family HMM TIGR01068; thioredoxin 2 2758350..2758769 Escherichia coli HS 5592661 YP_001459381.1 CDS EcHS_A2740 NC_009800.1 2758838 2759536 D identified by match to protein family HMM PF03942; DTW domain-containing protein 2758838..2759536 Escherichia coli HS 5592662 YP_001459382.1 CDS EcHS_A2741 NC_009800.1 2759568 2762228 D identified by similarity to GB:BAA07751.1; match to protein family HMM PF00583; match to protein family HMM PF02629; CoA-binding domain/acetyltransferase domain-containing protein 2759568..2762228 Escherichia coli HS 5591412 YP_001459383.1 CDS pssA NC_009800.1 2762342 2763697 D catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome; phosphatidylserine synthase 2762342..2763697 Escherichia coli HS 5591413 YP_001459384.1 CDS EcHS_A2743 NC_009800.1 2763743 2764066 D yfiM; hypothetical protein 2763743..2764066 Escherichia coli HS 5591414 YP_001459385.1 CDS EcHS_A2749 NC_009800.1 2771038 2771172 D identified by similarity to GB:AAN81562.1; hypothetical protein 2771038..2771172 Escherichia coli HS 5594409 YP_001459386.1 CDS clpB NC_009800.1 2771214 2773787 R identified by match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728; match to protein family HMM TIGR03346; protein disaggregation chaperone complement(2771214..2773787) Escherichia coli HS 5595203 YP_001459387.1 CDS EcHS_A2751 NC_009800.1 2773917 2774648 R yfiH; identified by similarity to PDB:1XAF_A; match to protein family HMM PF02578; match to protein family HMM TIGR00726; hypothetical protein complement(2773917..2774648) Escherichia coli HS 5595204 YP_001459388.1 CDS rluD NC_009800.1 2774645 2775625 R responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase D complement(2774645..2775625) Escherichia coli HS 5595205 YP_001459389.1 CDS EcHS_A2753 NC_009800.1 2775760 2776497 D with YaeT, NlpB and YfgL forms a complex involved in the proper assembly and/or targeting of OMPs to the outer membrane; involved in resistance to ampicillin and tetracycline; outer membrane protein assembly complex subunit YfiO 2775760..2776497 Escherichia coli HS 5593277 YP_001459390.1 CDS EcHS_A2754 NC_009800.1 2776768 2777109 D associated with 30S ribosomal subunit; interferes with translation elongation; translation inhibitor protein RaiA 2776768..2777109 Escherichia coli HS 5593278 YP_001459391.1 CDS pheA NC_009800.1 2777358 2778518 D catalyzing the formation of prephenate from chorismate and the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; bifunctional chorismate mutase/prephenate dehydratase 2777358..2778518 Escherichia coli HS 5593279 YP_001459392.1 CDS tyrA NC_009800.1 2778561 2779682 R catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis; bifunctional chorismate mutase/prephenate dehydrogenase complement(2778561..2779682) Escherichia coli HS 5595387 YP_001459393.1 CDS aroF NC_009800.1 2779693 2780763 R catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase complement(2779693..2780763) Escherichia coli HS 5595388 YP_001459394.1 CDS EcHS_A2759 NC_009800.1 2780973 2781323 D hypothetical protein 2780973..2781323 Escherichia coli HS 5595389 YP_001459395.1 CDS EcHS_A2760 NC_009800.1 2781357 2781632 D identified by match to protein family HMM PF03811; IS1, transposase orfA 2781357..2781632 Escherichia coli HS 5593536 YP_001459396.1 CDS EcHS_A2761 NC_009800.1 2781551 2782054 D identified by match to protein family HMM PF03400; IS1, transposase orfB 2781551..2782054 Escherichia coli HS 5593537 YP_001459397.1 CDS EcHS_A2762 NC_009800.1 2782264 2782782 D identified by similarity to SP:P64548; hypothetical protein 2782264..2782782 Escherichia coli HS 5593538 YP_001459398.1 CDS EcHS_A2763 NC_009800.1 2782775 2783998 D identified by match to protein family HMM PF00672; match to protein family HMM PF00990; match to protein family HMM TIGR00254; hypothetical protein 2782775..2783998 Escherichia coli HS 5595377 YP_001459399.1 CDS EcHS_A2764 NC_009800.1 2784014 2784496 D identified by match to protein family HMM PF00691; outer membrane lipoprotein 2784014..2784496 Escherichia coli HS 5595378 YP_001459400.1 CDS rplS NC_009800.1 2784572 2784919 R this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 complement(2784572..2784919) Escherichia coli HS 5595379 YP_001459401.1 CDS trmD NC_009800.1 2784961 2785728 R methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase complement(2784961..2785728) Escherichia coli HS 5591700 YP_001459402.1 CDS rimM NC_009800.1 2785759 2786307 R Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM complement(2785759..2786307) Escherichia coli HS 5591701 YP_001459403.1 CDS rpsP NC_009800.1 2786326 2786574 R binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 complement(2786326..2786574) Escherichia coli HS 5591702 YP_001459404.1 CDS ffh NC_009800.1 2786711 2788072 R with 4.5S RNA forms a signal recognition particle involved in targeting and integration of inner membrane proteins; signal recognition particle protein complement(2786711..2788072) Escherichia coli HS 5591097 YP_001459405.1 CDS EcHS_A2770 NC_009800.1 2788164 2789030 D identified by match to protein family HMM PF01578; cytochrome C assembly protein 2788164..2789030 Escherichia coli HS 5591098 YP_001459406.1 CDS EcHS_A2771 NC_009800.1 2789075 2790337 D identified by match to protein family HMM PF00571; match to protein family HMM PF01595; match to protein family HMM PF03471; hypothetical protein 2789075..2790337 Escherichia coli HS 5591099 YP_001459407.1 CDS grpE NC_009800.1 2790392 2790985 R with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE complement(2790392..2790985) Escherichia coli HS 5594684 YP_001459408.1 CDS ppnK NC_009800.1 2791108 2791986 D catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 2791108..2791986 Escherichia coli HS 5594685 YP_001459409.1 CDS recN NC_009800.1 2792072 2793733 D identified by similarity to SP:P05824; match to protein family HMM PF02463; match to protein family HMM TIGR00634; recombination and repair protein 2792072..2793733 Escherichia coli HS 5594686 YP_001459410.1 CDS EcHS_A2775 NC_009800.1 2793882 2794223 D identified by match to protein family HMM PF04355; hypothetical protein 2793882..2794223 Escherichia coli HS 5592959 YP_001459411.1 CDS EcHS_A2776 NC_009800.1 2794285 2794575 R identified by similarity to SP:P52119; match to protein family HMM PF03658; hypothetical protein complement(2794285..2794575) Escherichia coli HS 5592960 YP_001459412.1 CDS EcHS_A2777 NC_009800.1 2794565 2795002 R identified by match to protein family HMM PF03364; hypothetical protein complement(2794565..2795002) Escherichia coli HS 5592961 YP_001459413.1 CDS smpB NC_009800.1 2795173 2795655 D binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 2795173..2795655 Escherichia coli HS 5594203 YP_001459414.1 CDS EcHS_A2780 NC_009800.1 2796878 2797246 D identified by glimmer; hypothetical protein 2796878..2797246 Escherichia coli HS 5594205 YP_001459415.1 CDS EcHS_A2782 NC_009800.1 2797526 2797618 R identified by glimmer; hypothetical protein complement(2797526..2797618) Escherichia coli HS 5592020 YP_001459416.1 CDS EcHS_A2781 NC_009800.1 2797594 2797788 D identified by match to protein family HMM PF06183; DinI family protein 2797594..2797788 Escherichia coli HS 5592021 YP_001459417.1 CDS EcHS_A2783 NC_009800.1 2798026 2798973 D identified by glimmer; hypothetical protein 2798026..2798973 Escherichia coli HS 5592022 YP_001459418.1 CDS EcHS_A2784 NC_009800.1 2799086 2799670 R identified by similarity to SP:P03740; match to protein family HMM PF02413; tail fiber assembly protein complement(2799086..2799670) Escherichia coli HS 5591932 YP_001459419.1 CDS EcHS_A2785 NC_009800.1 2799816 2800319 R identified by match to protein family HMM PF03400; IS1, transposase orfB complement(2799816..2800319) Escherichia coli HS 5591933 YP_001459420.1 CDS EcHS_A2786 NC_009800.1 2800238 2800513 R identified by match to protein family HMM PF03811; IS1, transposase orfA complement(2800238..2800513) Escherichia coli HS 5591934 YP_001459421.1 CDS EcHS_A2787 NC_009800.1 2800743 2801225 R identified by similarity to GB:AAZ89410.1; hypothetical protein complement(2800743..2801225) Escherichia coli HS 5594739 YP_001459422.1 CDS EcHS_A2788 NC_009800.1 2801287 2802099 R identified by similarity to GB:AAP17067.1; match to protein family HMM PF00665; ISEhe3, transposase orfB complement(2801287..2802099) Escherichia coli HS 5594740 YP_001459423.1 CDS EcHS_A2789 NC_009800.1 2802156 2802434 R identified by match to protein family HMM PF01527; ISEhe3, transposase orfA complement(2802156..2802434) Escherichia coli HS 5594741 YP_001459424.1 CDS EcHS_A2790 NC_009800.1 2802472 2802585 D identified by glimmer; hypothetical protein 2802472..2802585 Escherichia coli HS 5593749 YP_001459425.1 CDS EcHS_A2791 NC_009800.1 2802963 2803115 R NULL; identified by glimmer; hypothetical protein complement(2802963..2803115) Escherichia coli HS 5593750 YP_001459426.1 CDS EcHS_A2793 NC_009800.1 2803842 2806094 D identified by match to protein family HMM PF00128; match to protein family HMM PF02806; alpha amylase 2803842..2806094 Escherichia coli HS 5595421 YP_001459427.1 CDS EcHS_A2794 NC_009800.1 2806430 2807407 D in Escherichia coli this gene is induced by carbon starvation and depends on sigma S and cAMP-CRP; the structure of the Gab protein shows it is a member of non-heme iron (II)-dependent oxygenase superfamily which includes clavamini acid synthases; forms homotetramers in solution; hypothetical protein 2806430..2807407 Escherichia coli HS 5595422 YP_001459428.1 CDS EcHS_A2795 NC_009800.1 2807426 2808694 D catalyzed the formation of 2-ketoglutarate from 2-hydroxyglutarate; hydroxyglutarate oxidase 2807426..2808694 Escherichia coli HS 5593219 YP_001459429.1 CDS gabD NC_009800.1 2808717 2810165 D catalyzes the formation of succinate from succinate semialdehyde; NADP dependent; succinate-semialdehyde dehydrogenase I 2808717..2810165 Escherichia coli HS 5593220 YP_001459430.1 CDS gabT2 NC_009800.1 2810179 2811459 D catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; 4-aminobutyrate aminotransferase 2810179..2811459 Escherichia coli HS 5593221 YP_001459431.1 CDS gabP NC_009800.1 2811697 2813097 D identified by similarity to SP:P25527; match to protein family HMM PF00324; match to protein family HMM TIGR01773; gamma-aminobutyrate transporter 2811697..2813097 Escherichia coli HS 5591748 YP_001459432.1 CDS csiR NC_009800.1 2813118 2813780 D regulator of gab gene expression; DNA-binding transcriptional regulator CsiR 2813118..2813780 Escherichia coli HS 5591749 YP_001459433.1 CDS EcHS_A2800 NC_009800.1 2813781 2814230 R identified by match to protein family HMM PF01476; match to protein family HMM PF04972; LysM domain/BON superfamily protein complement(2813781..2814230) Escherichia coli HS 5591750 YP_001459434.1 CDS EcHS_A2801 NC_009800.1 2814314 2814472 R yqaE; identified by similarity to GB:AAV78517.1; match to protein family HMM PF01679; hypothetical protein complement(2814314..2814472) Escherichia coli HS 5594751 YP_001459435.1 CDS EcHS_A2802 NC_009800.1 2814655 2814954 D identified by match to protein family HMM PF01022; ArsR family transcriptional regulator 2814655..2814954 Escherichia coli HS 5594752 YP_001459436.1 CDS EcHS_A2803 NC_009800.1 2814964 2815488 D ygaP; identified by similarity to SP:P55734; inner membrane protein 2814964..2815488 Escherichia coli HS 5594753 YP_001459437.1 CDS stpA NC_009800.1 2815535 2815939 R identified by similarity to SP:P0ACG3; match to protein family HMM PF00816; DNA binding protein, nucleoid-associated complement(2815535..2815939) Escherichia coli HS 5595333 YP_001459438.1 CDS EcHS_A2805 NC_009800.1 2816353 2816481 D identified by similarity to GB:AAN81672.1; hypothetical protein 2816353..2816481 Escherichia coli HS 5595334 YP_001459439.1 CDS EcHS_A2806 NC_009800.1 2816607 2817056 D identified by similarity to SP:P64553; match to protein family HMM PF06610; hypothetical protein 2816607..2817056 Escherichia coli HS 5595335 YP_001459440.1 CDS EcHS_A2807 NC_009800.1 2817093 2817437 R ygaC; hypothetical protein complement(2817093..2817437) Escherichia coli HS 5594363 YP_001459441.1 CDS EcHS_A2808 NC_009800.1 2817589 2817918 D ygaM; identified by similarity to GB:AAL21687.1; match to protein family HMM PF05957; hypothetical protein 2817589..2817918 Escherichia coli HS 5594364 YP_001459442.1 CDS nrdH NC_009800.1 2818166 2818411 D identified by match to protein family HMM PF00462; match to protein family HMM TIGR02194; glutaredoxin-like protein 2818166..2818411 Escherichia coli HS 5594365 YP_001459443.1 CDS nrdI NC_009800.1 2818408 2818818 D in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein 2818408..2818818 Escherichia coli HS 5591323 YP_001459444.1 CDS nrdE NC_009800.1 2818791 2820935 D Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 2818791..2820935 Escherichia coli HS 5591324 YP_001459445.1 CDS nrdF NC_009800.1 2820945 2821904 D B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 2820945..2821904 Escherichia coli HS 5591325 YP_001459446.1 CDS proV NC_009800.1 2822258 2823460 D with ProWX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter ATP-binding subunit 2822258..2823460 Escherichia coli HS 5595488 YP_001459447.1 CDS proW NC_009800.1 2823453 2824517 D with ProVX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter membrane protein 2823453..2824517 Escherichia coli HS 5595489 YP_001459448.1 CDS proX NC_009800.1 2824575 2825567 D with ProVW, part of the high-affinity transport system for the osmoprotectant glycine betaine; glycine betaine transporter periplasmic subunit 2824575..2825567 Escherichia coli HS 5595490 YP_001459449.1 CDS EcHS_A2816 NC_009800.1 2825599 2825778 R identified by glimmer; hypothetical protein complement(2825599..2825778) Escherichia coli HS 5595478 YP_001459450.1 CDS EcHS_A2817 NC_009800.1 2825859 2827043 D identified by match to protein family HMM PF07690; major facilitator family transporter 2825859..2827043 Escherichia coli HS 5595479 YP_001459451.1 CDS EcHS_A2818 NC_009800.1 2827167 2827904 D ygaZ; identified by match to protein family HMM PF03591; branched chain amino acid ABC transporter 2827167..2827904 Escherichia coli HS 5595480 YP_001459452.1 CDS EcHS_A2819 NC_009800.1 2827894 2828229 D ygaH; identified by similarity to GB:AAZ89437.1; hypothetical protein 2827894..2828229 Escherichia coli HS 5594514 YP_001459453.1 CDS mprA NC_009800.1 2828320 2828850 D DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; negative regulator of the multidrug operon emrAB; transcriptional repressor MprA 2828320..2828850 Escherichia coli HS 5594515 YP_001459454.1 CDS emrA NC_009800.1 2828977 2830149 D identified by match to protein family HMM PF00529; match to protein family HMM TIGR00998; multidrug resistance protein A 2828977..2830149 Escherichia coli HS 5594516 YP_001459455.1 CDS emrB NC_009800.1 2830166 2831704 D identified by similarity to SP:P27304; match to protein family HMM PF07690; match to protein family HMM TIGR00711; multidrug resistance protein B 2830166..2831704 Escherichia coli HS 5595415 YP_001459456.1 CDS luxS NC_009800.1 2831768 2832283 R catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase complement(2831768..2832283) Escherichia coli HS 5595416 YP_001459457.1 CDS gshA NC_009800.1 2832433 2833989 R involved in the first step of glutathione biosynthesis; glutamate--cysteine ligase complement(2832433..2833989) Escherichia coli HS 5592014 YP_001459458.1 CDS EcHS_A2825 NC_009800.1 2834062 2834490 R yqaA; hypothetical protein complement(2834062..2834490) Escherichia coli HS 5592015 YP_001459459.1 CDS EcHS_A2826 NC_009800.1 2834487 2835053 R YqaB; catalyzes the dephosphorylation of fructose 1-phosphate, 6-phosphogluconate and p-nitrophenyl phosphate (pNPP); presents beta-phosphoglucomutase activity at a lower extent; fructose-1-phosphatase complement(2834487..2835053) Escherichia coli HS 5592016 YP_001459460.1 CDS csrA NC_009800.1 2836378 2836563 R affects carbohydrate metabolism; has regulatory role in many processes; carbon storage regulator complement(2836378..2836563) Escherichia coli HS 5591224 YP_001459461.1 CDS alaS NC_009800.1 2836798 2839428 R Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase complement(2836798..2839428) Escherichia coli HS 5591225 YP_001459462.1 CDS recX NC_009800.1 2839556 2840056 R binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX complement(2839556..2840056) Escherichia coli HS 5594733 YP_001459463.1 CDS recA NC_009800.1 2840125 2841186 R catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A complement(2840125..2841186) Escherichia coli HS 5594734 YP_001459464.1 CDS EcHS_A2836 NC_009800.1 2841266 2841763 R ygaD; identified by match to protein family HMM PF02464; match to protein family HMM TIGR00199; competence damage-inducible protein A complement(2841266..2841763) Escherichia coli HS 5594735 YP_001459465.1 CDS mltB NC_009800.1 2841908 2842993 R membrane-bound lytic murein transglycosylase B; catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan; murein hydrolase B complement(2841908..2842993) Escherichia coli HS 5594523 YP_001459466.1 CDS srlA NC_009800.1 2843249 2843812 D identified by match to protein family HMM PF03608; match to protein family HMM TIGR00821; PTS system, glucitol/sorbitol-specific, IIC component 2843249..2843812 Escherichia coli HS 5594524 YP_001459467.1 CDS srlE NC_009800.1 2843809 2844768 D identified by match to protein family HMM PF03612; match to protein family HMM PF07663; match to protein family HMM TIGR00825; PTS system, glucitol/sorbitol-specific, IIB component 2843809..2844768 Escherichia coli HS 5594525 YP_001459468.1 CDS srlB NC_009800.1 2844779 2845150 D phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; glucitol/sorbitol-specific PTS system component IIA 2844779..2845150 Escherichia coli HS 5594505 YP_001459469.1 CDS srlD NC_009800.1 2845154 2845933 D catalyzes the conversion of sorbitol 6-phosphate into fructose 6-phosphate; sorbitol-6-phosphate dehydrogenase 2845154..2845933 Escherichia coli HS 5594506 YP_001459470.1 CDS gutM NC_009800.1 2846039 2846398 D regulator for glucitol utilization; DNA-binding transcriptional activator GutM 2846039..2846398 Escherichia coli HS 5594507 YP_001459471.1 CDS srlR NC_009800.1 2846465 2847238 D regulates genes involved in glucitol utilization; DNA-binding transcriptional repressor SrlR 2846465..2847238 Escherichia coli HS 5593621 YP_001459472.1 CDS gutQ NC_009800.1 2847231 2848196 D catalyzes the conversion of D-arabinose 5-phosphate to D-ribulose-5-phosphate; D-arabinose 5-phosphate isomerase 2847231..2848196 Escherichia coli HS 5593622 YP_001459473.1 CDS norR NC_009800.1 2848193 2849707 R Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon; anaerobic nitric oxide reductase transcription regulator complement(2848193..2849707) Escherichia coli HS 5593623 YP_001459474.1 CDS norV NC_009800.1 2849894 2851333 D detoxifies nitric oxide using NADH; anaerobic nitric oxide reductase flavorubredoxin 2849894..2851333 Escherichia coli HS 5592310 YP_001459475.1 CDS norW NC_009800.1 2851330 2852463 D catalyzes the reduction of the rubredoxin moiety of nitric oxide reductase; nitric oxide reductase 2851330..2852463 Escherichia coli HS 5592311 YP_001459476.1 CDS hypF NC_009800.1 2852591 2854843 R identified by match to protein family HMM PF00708; match to protein family HMM PF01300; match to protein family HMM PF07503; match to protein family HMM TIGR00143; carbamoyltransferase HypF complement(2852591..2854843) Escherichia coli HS 5592312 YP_001459477.1 CDS EcHS_A2849 NC_009800.1 2854996 2855523 R involved in electron transport from formate to hydrogen; electron transport protein HydN complement(2854996..2855523) Escherichia coli HS 5592196 YP_001459478.1 CDS ascG NC_009800.1 2855672 2856685 R identified by similarity to SP:P24242; match to protein family HMM PF00356; match to protein family HMM PF00532; transcriptional regulator AscG complement(2855672..2856685) Escherichia coli HS 5592197 YP_001459479.1 CDS ascF NC_009800.1 2856942 2858399 D phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; cellobiose/arbutin/salicin-specific PTS system components IIBC 2856942..2858399 Escherichia coli HS 5592198 YP_001459480.1 CDS ascB NC_009800.1 2858408 2859832 D identified by similarity to SP:P24240; match to protein family HMM PF00232; cryptic 6-phospho-beta-glucosidase 2858408..2859832 Escherichia coli HS 5593891 YP_001459481.1 CDS hycI NC_009800.1 2859991 2860461 R involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE; hydrogenase 3 maturation protease complement(2859991..2860461) Escherichia coli HS 5593892 YP_001459482.1 CDS EcHS_A2854 NC_009800.1 2860454 2860864 R identified by match to protein family HMM PF07450; formate hydrogenlyase maturation protein complement(2860454..2860864) Escherichia coli HS 5593893 YP_001459483.1 CDS hycG NC_009800.1 2860861 2861628 R identified by similarity to SP:P16433; match to protein family HMM PF01058; formate hydrogenlyase, subunit G complement(2860861..2861628) Escherichia coli HS 5591133 YP_001459484.1 CDS hycF NC_009800.1 2861628 2862170 R electron transfer protein for hydrogenase-3; the formate hydrogenlyase complex comprises of a formate dehydrogenase, unidentified electron carriers and hydrogenase-3; in this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate; formate hydrogenlyase complex iron-sulfur subunit complement(2861628..2862170) Escherichia coli HS 5591134 YP_001459485.1 CDS hycE NC_009800.1 2862180 2863889 R identified by similarity to SP:P16431; match to protein family HMM PF00329; match to protein family HMM PF00346; formate hydrogenlyase, subunit E complement(2862180..2863889) Escherichia coli HS 5591135 YP_001459486.1 CDS hycD NC_009800.1 2863907 2864830 R identified by similarity to SP:P16430; match to protein family HMM PF00146; formate hydrogenlyase, subunit D complement(2863907..2864830) Escherichia coli HS 5591209 YP_001459487.1 CDS hycC NC_009800.1 2864833 2866659 R catalyzes the oxidation of formate to carbon dioxide and molecular hydrogen; formate hydrogenlyase comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (subunit 3); formate hydrogenlyase subunit 3 complement(2864833..2866659) Escherichia coli HS 5591210 YP_001459488.1 CDS hycB NC_009800.1 2866656 2867267 R identified by similarity to SP:P0AAK1; match to protein family HMM PF00037; formate hydrogenlyase, subunit B complement(2866656..2867267) Escherichia coli HS 5591211 YP_001459489.1 CDS hycA NC_009800.1 2867392 2867853 R regulates several genes involved in the formate hydrogenlyase system; seems to prevent binding of FhlA transcriptional activator to the activator sequence of hyc operon; formate hydrogenlyase regulatory protein HycA complement(2867392..2867853) Escherichia coli HS 5591267 YP_001459490.1 CDS EcHS_A2862 NC_009800.1 2867941 2868024 R NULL; identified by glimmer; hypothetical protein complement(2867941..2868024) Escherichia coli HS 5591268 YP_001459491.1 CDS hypA NC_009800.1 2868065 2868415 D plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein 2868065..2868415 Escherichia coli HS 5591269 YP_001459492.1 CDS hypB NC_009800.1 2868419 2869291 D GTP hydrolase involved in nickel liganding into hydrogenases; hydrogenase nickel incorporation protein HypB 2868419..2869291 Escherichia coli HS 5591149 YP_001459493.1 CDS hypC2 NC_009800.1 2869282 2869554 D HypC; accessory protein necessary for maturation of the hydrogenase isoforms 1, 2 and 3; forms a complex with HypD, HypE, and HypF proteins, which is the site of ligand biosynthesis and attachment to the iron atom of the NiFe site in the hydrogenase; hydrogenase assembly chaperone 2869282..2869554 Escherichia coli HS 5591150 YP_001459494.1 CDS hypD NC_009800.1 2869554 2870675 D identified by similarity to SP:P24192; match to protein family HMM PF01924; match to protein family HMM TIGR00075; hydrogenase expression/formation protein HypD 2869554..2870675 Escherichia coli HS 5591151 YP_001459495.1 CDS hypE NC_009800.1 2870672 2871682 D identified by similarity to SP:P24193; match to protein family HMM PF00586; match to protein family HMM PF02769; match to protein family HMM TIGR02124; hydrogenase expression/formation protein HypE 2870672..2871682 Escherichia coli HS 5591317 YP_001459496.1 CDS fhlA NC_009800.1 2871756 2873834 D identified by similarity to SP:P19323; match to protein family HMM PF00158; match to protein family HMM PF01590; match to protein family HMM PF02954; match to protein family HMM PF07728; formate hydrogenlyase transcriptional activator 2871756..2873834 Escherichia coli HS 5591318 YP_001459497.1 CDS EcHS_A2869 NC_009800.1 2873871 2874224 R ygbA; identified by similarity to SP:P25728; hypothetical protein complement(2873871..2874224) Escherichia coli HS 5591319 YP_001459498.1 CDS EcHS_A2870 NC_009800.1 2874301 2874435 R NULL; identified by glimmer; hypothetical protein complement(2874301..2874435) Escherichia coli HS 5591358 YP_001459499.1 CDS mutS NC_009800.1 2874511 2877072 D This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 2874511..2877072 Escherichia coli HS 5591359 YP_001459500.1 CDS pphB NC_009800.1 2877178 2877834 D identified by match to protein family HMM PF00149; serine/threonine-specific protein phosphatase 2 2877178..2877834 Escherichia coli HS 5591360 YP_001459501.1 CDS EcHS_A2873 NC_009800.1 2877885 2878652 R identified by match to protein family HMM PF00455; match to protein family HMM PF08220; match to protein family HMM PF08279; DeoR family transcriptional regulator complement(2877885..2878652) Escherichia coli HS 5591511 YP_001459502.1 CDS EcHS_A2874 NC_009800.1 2878848 2879756 D identified by match to protein family HMM PF03446; 6-phosphogluconate dehydrogenase 2878848..2879756 Escherichia coli HS 5591512 YP_001459503.1 CDS EcHS_A2875 NC_009800.1 2879753 2881015 D ygbK; identified by match to protein family HMM PF07005; hypothetical protein 2879753..2881015 Escherichia coli HS 5591513 YP_001459504.1 CDS EcHS_A2876 NC_009800.1 2881012 2881650 D identified by match to protein family HMM PF00596; aldolase 2881012..2881650 Escherichia coli HS 5591378 YP_001459505.1 CDS EcHS_A2877 NC_009800.1 2881655 2882431 D ygbM; identified by match to protein family HMM PF01261; hypothetical protein 2881655..2882431 Escherichia coli HS 5591379 YP_001459506.1 CDS EcHS_A2878 NC_009800.1 2882520 2883884 D member of the Gnt family of gluconate transporters; not involved in gluconate transport; unknown function; inner membrane permease YgbN 2882520..2883884 Escherichia coli HS 5591380 YP_001459507.1 CDS rpoS NC_009800.1 2883978 2884970 R sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor controls a regulon of genes required for protection against external stresses; RNA polymerase sigma factor RpoS complement(2883978..2884970) Escherichia coli HS 5591682 YP_001459508.1 CDS nlpD NC_009800.1 2885033 2886172 R outer membrane lipoprotein involved in stationary-phase cell survival; similar to LppB virulence determinant from Haemophilus somnus; lipoprotein NlpD complement(2885033..2886172) Escherichia coli HS 5591683 YP_001459509.1 CDS pcm NC_009800.1 2886312 2886938 R catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins; protein-L-isoaspartate O-methyltransferase complement(2886312..2886938) Escherichia coli HS 5591684 YP_001459510.1 CDS surE NC_009800.1 2886932 2887693 R catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate; stationary phase survival protein SurE complement(2886932..2887693) Escherichia coli HS 5591782 YP_001459511.1 CDS truD NC_009800.1 2887674 2888723 R catalyzes the modification of U13 in tRNA(Glu); tRNA pseudouridine synthase D complement(2887674..2888723) Escherichia coli HS 5591783 YP_001459512.1 CDS ispF NC_009800.1 2888720 2889199 R catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase complement(2888720..2889199) Escherichia coli HS 5591784 YP_001459513.1 CDS ispD NC_009800.1 2889199 2889909 R 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase complement(2889199..2889909) Escherichia coli HS 5591860 YP_001459514.1 CDS ftsB NC_009800.1 2889928 2890239 R forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein; cell division protein FtsB complement(2889928..2890239) Escherichia coli HS 5591861 YP_001459515.1 CDS EcHS_A2887 NC_009800.1 2890433 2890756 R identified by similarity to SP:P46141; similarity to GB:AAG42462.1; hypothetical protein complement(2890433..2890756) Escherichia coli HS 5591862 YP_001459516.1 CDS cysC NC_009800.1 2890806 2891411 R converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis; adenylylsulfate kinase complement(2890806..2891411) Escherichia coli HS 5591917 YP_001459517.1 CDS cysN NC_009800.1 2891411 2892838 R may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ; sulfate adenylyltransferase subunit 1 complement(2891411..2892838) Escherichia coli HS 5591918 YP_001459518.1 CDS cysD NC_009800.1 2892840 2893748 R with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; sulfate adenylyltransferase subunit 2 complement(2892840..2893748) Escherichia coli HS 5591919 YP_001459519.1 CDS iap NC_009800.1 2894000 2895037 D catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3; alkaline phosphatase 2894000..2895037 Escherichia coli HS 5591944 YP_001459520.1 CDS EcHS_A2892 NC_009800.1 2895086 2895232 R identified by glimmer; hypothetical protein complement(2895086..2895232) Escherichia coli HS 5591945 YP_001459521.1 CDS EcHS_A2893 NC_009800.1 2895276 2895536 D identified by glimmer; hypothetical protein 2895276..2895536 Escherichia coli HS 5591946 YP_001459522.1 CDS cas1 NC_009800.1 2896088 2897005 R identified by match to protein family HMM TIGR00287; CRISPR-associated Cas1 family protein complement(2896088..2897005) Escherichia coli HS 5592173 YP_001459523.1 CDS cse3 NC_009800.1 2897021 2897620 R identified by match to protein family HMM PF08798; match to protein family HMM TIGR01907; CRISPR-associated Cse3 family protein complement(2897021..2897620) Escherichia coli HS 5592174 YP_001459524.1 CDS EcHS_A2896 NC_009800.1 2897607 2898287 R identified by match to protein family HMM TIGR01868; match to protein family HMM TIGR02593; CRISPR-associated Cas5 family Ecoli subtype protein complement(2897607..2898287) Escherichia coli HS 5592175 YP_001459525.1 CDS cse4 NC_009800.1 2898284 2899375 R identified by match to protein family HMM TIGR01869; CRISPR-associated Cse4 family protein complement(2898284..2899375) Escherichia coli HS 5592513 YP_001459526.1 CDS cse2 NC_009800.1 2899388 2899870 R identified by match to protein family HMM TIGR02548; CRISPR-associated Cse2 family protein complement(2899388..2899870) Escherichia coli HS 5592514 YP_001459527.1 CDS cse1 NC_009800.1 2899863 2901371 R unknown function; in E. coli this protein is regulated by BaeR, a protein involved in resistance to novobiocin and deoxycholate; hypothetical protein complement(2899863..2901371) Escherichia coli HS 5592515 YP_001459528.1 CDS EcHS_A2900 NC_009800.1 2901368 2901487 R identified by glimmer; hypothetical protein complement(2901368..2901487) Escherichia coli HS 5595095 YP_001459529.1 CDS cas3 NC_009800.1 2901786 2904452 R identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM TIGR01587; hypothetical protein complement(2901786..2904452) Escherichia coli HS 5595096 YP_001459530.1 CDS cysH NC_009800.1 2904811 2905545 R catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite; phosphoadenosine phosphosulfate reductase complement(2904811..2905545) Escherichia coli HS 5595097 YP_001459531.1 CDS cysI NC_009800.1 2905619 2907331 R hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide; sulfite reductase subunit beta complement(2905619..2907331) Escherichia coli HS 5592257 YP_001459532.1 CDS cysJ NC_009800.1 2907331 2909130 R catalyzes the reduction of sulfite to sulfide in the biosynthesis of L-cysteine from sulfate; a flavoprotein with flavin reductase activity; sulfite reductase subunit alpha complement(2907331..2909130) Escherichia coli HS 5592258 YP_001459533.1 CDS queD NC_009800.1 2909446 2909811 D identified by match to protein family HMM PF01242; match to protein family HMM TIGR00039; match to protein family HMM TIGR03367; queuosine biosynthesis protein QueD 2909446..2909811 Escherichia coli HS 5592259 YP_001459534.1 CDS EcHS_A2906 NC_009800.1 2909889 2911160 D identified by match to protein family HMM PF01266; match to protein family HMM PF01494; match to protein family HMM PF03486; match to protein family HMM PF07992; pyridine nucleotide-disulfide oxidoreductase 2909889..2911160 Escherichia coli HS 5592706 YP_001459535.1 CDS EcHS_A2907 NC_009800.1 2911151 2911411 D ygcO; identified by similarity to SP:P68646; ferredoxin 2911151..2911411 Escherichia coli HS 5592707 YP_001459536.1 CDS EcHS_A2908 NC_009800.1 2911428 2912003 D identified by match to protein family HMM PF04309; glycerol-3-phosphate responsive antiterminator 2911428..2912003 Escherichia coli HS 5592708 YP_001459537.1 CDS EcHS_A2909 NC_009800.1 2912151 2913011 R ygcQ; identified by match to protein family HMM PF00766; electron transfer flavoprotein complement(2912151..2913011) Escherichia coli HS 5592736 YP_001459538.1 CDS EcHS_A2910 NC_009800.1 2913008 2913787 R identified by match to protein family HMM PF01012; electron transfer flavoprotein complement(2913008..2913787) Escherichia coli HS 5592737 YP_001459539.1 CDS EcHS_A2911 NC_009800.1 2913765 2915102 R identified by match to protein family HMM PF00083; match to protein family HMM PF07690; major facilitator family transporter complement(2913765..2915102) Escherichia coli HS 5592738 YP_001459540.1 CDS EcHS_A2912 NC_009800.1 2915196 2916650 R ygcU; identified by match to protein family HMM PF01565; match to protein family HMM PF02913; FAD binding domain-containing protein complement(2915196..2916650) Escherichia coli HS 5595190 YP_001459541.1 CDS EcHS_A2913 NC_009800.1 2916720 2917505 R ygcW; identified by match to protein family HMM PF00106; short chain dehydrogenase/reductase oxidoreductase complement(2916720..2917505) Escherichia coli HS 5595191 YP_001459542.1 CDS EcHS_A2914 NC_009800.1 2917824 2919101 D identified by match to protein family HMM PF07690; major facilitator family transporter 2917824..2919101 Escherichia coli HS 5595192 YP_001459543.1 CDS EcHS_A2915 NC_009800.1 2919128 2920606 D ygcE; identified by match to protein family HMM PF00370; match to protein family HMM PF02782; carbohydrate kinase, FGGY family protein 2919128..2920606 Escherichia coli HS 5592975 YP_001459545.1 CDS EcHS_A2917 NC_009800.1 2921674 2921844 D identified by glimmer; hypothetical protein 2921674..2921844 Escherichia coli HS 5592977 YP_001459546.1 CDS EcHS_A2918 NC_009800.1 2922179 2922850 R ygcF; hypothetical protein complement(2922179..2922850) Escherichia coli HS 5593246 YP_001459547.1 CDS EcHS_A2919 NC_009800.1 2922989 2923129 D identified by glimmer; hypothetical protein 2922989..2923129 Escherichia coli HS 5593247 YP_001459548.1 CDS EcHS_A2920 NC_009800.1 2923143 2923871 D identified by match to protein family HMM PF04536; hypothetical protein 2923143..2923871 Escherichia coli HS 5593248 YP_001459549.1 CDS EcHS_A2921 NC_009800.1 2923905 2924180 D identified by match to protein family HMM PF03811; IS1, transposase orfA 2923905..2924180 Escherichia coli HS 5593261 YP_001459550.1 CDS EcHS_A2922 NC_009800.1 2924099 2924602 D identified by match to protein family HMM PF03400; IS1, transposase orfB 2924099..2924602 Escherichia coli HS 5593262 YP_001459551.1 CDS eno NC_009800.1 2924852 2926150 R enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase complement(2924852..2926150) Escherichia coli HS 5593263 YP_001459552.1 CDS pyrG NC_009800.1 2926238 2927875 R CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase complement(2926238..2927875) Escherichia coli HS 5593340 YP_001459553.1 CDS mazG NC_009800.1 2928103 2928894 R functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase Era; nucleoside triphosphate pyrophosphohydrolase complement(2928103..2928894) Escherichia coli HS 5593341 YP_001459554.1 CDS chpA NC_009800.1 2928965 2929300 R MazF; endoribonuclease; toxin of the ChpA-ChpR toxin-antitoxin system; toxin ChpA complement(2928965..2929300) Escherichia coli HS 5593342 YP_001459555.1 CDS chpR NC_009800.1 2929300 2929548 R part of the MazF-MazE toxin-antitoxin system; conteracts MazF; antitoxin MazE complement(2929300..2929548) Escherichia coli HS 5593552 YP_001459556.1 CDS relA NC_009800.1 2929626 2931860 R (p)ppGpp synthetase; catalyzes the formation of pppGpp and ppGpp from ATP and GTP or GDP; GDP/GTP pyrophosphokinase complement(2929626..2931860) Escherichia coli HS 5593553 YP_001459557.1 CDS rumA NC_009800.1 2931908 2933209 R in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]; 23S rRNA 5-methyluridine methyltransferase complement(2931908..2933209) Escherichia coli HS 5593554 YP_001459558.1 CDS barA NC_009800.1 2933266 2936022 D part of the two-component regulatory system with UvrY; involved in the regulation of carbon metabolism via the csrA/csrB regulatory system; hybrid sensory histidine kinase BarA 2933266..2936022 Escherichia coli HS 5593759 YP_001459559.1 CDS EcHS_A2931 NC_009800.1 2936254 2937594 R identified by match to protein family HMM PF01188; match to protein family HMM TIGR03247; glucarate dehydratase complement(2936254..2937594) Escherichia coli HS 5593760 YP_001459560.1 CDS EcHS_A2932 NC_009800.1 2937615 2938955 R identified by match to protein family HMM PF01188; match to protein family HMM PF02746; glucarate dehydratase complement(2937615..2938955) Escherichia coli HS 5593761 YP_001459561.1 CDS gudP NC_009800.1 2938957 2940309 R identified by match to protein family HMM PF07690; match to protein family HMM TIGR00893; glucarate permease complement(2938957..2940309) Escherichia coli HS 5595468 YP_001459562.1 CDS EcHS_A2934 NC_009800.1 2940744 2941193 R An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin complement(2940744..2941193) Escherichia coli HS 5595469 YP_001459563.1 CDS truC NC_009800.1 2941211 2941993 R catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp; tRNA pseudouridine synthase C complement(2941211..2941993) Escherichia coli HS 5595470 YP_001459564.1 CDS EcHS_A2936 NC_009800.1 2941993 2942322 R identified by similarity to SP:Q46919; match to protein family HMM PF04287; hypothetical protein complement(2941993..2942322) Escherichia coli HS 5593731 YP_001459565.1 CDS EcHS_A2937 NC_009800.1 2942944 2943489 R SecY regulator that either chelates excess SecY or negatively regulates the SecYE translocase function; SecY interacting protein Syd complement(2942944..2943489) Escherichia coli HS 5593733 YP_001459566.1 CDS queF NC_009800.1 2943557 2944405 D catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 2943557..2944405 Escherichia coli HS 5593734 YP_001459567.1 CDS EcHS_A2939 NC_009800.1 2944517 2945881 D identified by similarity to SP:P0ADS1; match to protein family HMM PF03641; hypothetical protein 2944517..2945881 Escherichia coli HS 5593735 YP_001459568.1 CDS EcHS_A2940 NC_009800.1 2946438 2947727 D identified by match to protein family HMM TIGR00814; serine transporter family protein 2946438..2947727 Escherichia coli HS 5593736 YP_001459569.1 CDS sdaB NC_009800.1 2947785 2949152 D identified by similarity to SP:P16095; match to protein family HMM PF03313; match to protein family HMM PF03315; match to protein family HMM TIGR00720; L-serine ammonia-lyase 2947785..2949152 Escherichia coli HS 5594010 YP_001459570.1 CDS xni NC_009800.1 2949174 2950019 D has 3'-5' exonuclease activity that preferentially acts on ssDNA; also 3'-phosphodiesterase activity at sites with 3' incised apurinic/apyrimidinic sites; can remove 3' phosphoglycolate groups; exonuclease IX 2949174..2950019 Escherichia coli HS 5594011 YP_001459571.1 CDS fucO NC_009800.1 2950074 2951222 R identified by match to protein family HMM PF00465; match to protein family HMM TIGR02638; L-1,2-propanediol oxidoreductase complement(2950074..2951222) Escherichia coli HS 5594012 YP_001459572.1 CDS fucA NC_009800.1 2951250 2951897 R catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase complement(2951250..2951897) Escherichia coli HS 5593998 YP_001459573.1 CDS fucP NC_009800.1 2952444 2953760 D identified by match to protein family HMM PF07690; match to protein family HMM TIGR00885; L-fucose transporter 2952444..2953760 Escherichia coli HS 5593999 YP_001459574.1 CDS fucI NC_009800.1 2953793 2955568 D catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose; L-fucose isomerase 2953793..2955568 Escherichia coli HS 5594000 YP_001459575.1 CDS fucK NC_009800.1 2955677 2957095 D identified by match to protein family HMM PF00370; match to protein family HMM PF02782; match to protein family HMM TIGR02628; L-fuculokinase 2955677..2957095 Escherichia coli HS 5594172 YP_001459576.1 CDS fucU NC_009800.1 2957097 2957519 D identified by similarity to SP:P0AEN8; match to protein family HMM PF05025; fucose operon protein FucU 2957097..2957519 Escherichia coli HS 5594173 YP_001459577.1 CDS fucR NC_009800.1 2957577 2958308 D regulates expression of genes involved in L-fucose utilization; DNA-binding transcriptional activator FucR 2957577..2958308 Escherichia coli HS 5594174 YP_001459578.1 CDS EcHS_A2950 NC_009800.1 2958352 2959452 R ygdE; identified by similarity to GB:AAP18132.1; RNA 2'-O-ribose methyltransferase complement(2958352..2959452) Escherichia coli HS 5593787 YP_001459579.1 CDS EcHS_A2951 NC_009800.1 2959445 2959840 R ygdD; identified by match to protein family HMM PF04241; hypothetical protein complement(2959445..2959840) Escherichia coli HS 5593788 YP_001459580.1 CDS gcvA NC_009800.1 2959859 2960776 R Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence; DNA-binding transcriptional activator GcvA complement(2959859..2960776) Escherichia coli HS 5593789 YP_001459581.1 CDS EcHS_A2953 NC_009800.1 2961127 2961354 R ygdI; identified by match to protein family HMM PF06004; lipoprotein complement(2961127..2961354) Escherichia coli HS 5594274 YP_001459582.1 CDS csdA NC_009800.1 2961546 2962751 D identified by match to protein family HMM PF00266; match to protein family HMM TIGR03392; cysteine sulfinate desulfinase 2961546..2962751 Escherichia coli HS 5594275 YP_001459583.1 CDS csdE NC_009800.1 2962751 2963194 D identified by similarity to SP:P0AGF2; match to protein family HMM PF02657; match to protein family HMM TIGR03391; cysteine desulfuration protein CsdE 2962751..2963194 Escherichia coli HS 5595276 YP_001459584.1 CDS EcHS_A2956 NC_009800.1 2963245 2964051 R identified by match to protein family HMM PF00899; ThiF family protein complement(2963245..2964051) Escherichia coli HS 5595277 YP_001459585.1 CDS EcHS_A2957 NC_009800.1 2964086 2964196 R identified by glimmer; hypothetical protein complement(2964086..2964196) Escherichia coli HS 5595278 YP_001459586.1 CDS mltA NC_009800.1 2964290 2965387 R membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase A complement(2964290..2965387) Escherichia coli HS 5594607 YP_001459587.1 CDS amiC NC_009800.1 2966076 2967329 R identified by similarity to SP:P63883; match to protein family HMM PF01520; match to protein family HMM TIGR01409; N-acetylmuramoyl-L-alanine amidase complement(2966076..2967329) Escherichia coli HS 5594625 YP_001459588.1 CDS argA NC_009800.1 2967561 2968892 D catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; N-acetylglutamate synthase 2967561..2968892 Escherichia coli HS 5594605 YP_001459589.1 CDS recD NC_009800.1 2968954 2970780 R helicase/nuclease; with RecBC catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit alpha complement(2968954..2970780) Escherichia coli HS 5594606 YP_001459590.1 CDS recB NC_009800.1 2970780 2974322 R helicase/nuclease; with RecCD catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit beta complement(2970780..2974322) Escherichia coli HS 5594873 YP_001459591.1 CDS ptrA NC_009800.1 2974315 2977203 R identified by similarity to SP:P05458; match to protein family HMM PF00675; match to protein family HMM PF05193; protease III complement(2974315..2977203) Escherichia coli HS 5594874 YP_001459592.1 CDS recC NC_009800.1 2977379 2980747 R catalyzes ATP-dependent exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides; component of the RecBCD (Exo V) helicase/nuclease complex that is essential for recombination; exonuclease V subunit gamma complement(2977379..2980747) Escherichia coli HS 5594875 YP_001459593.1 CDS ppdC NC_009800.1 2980760 2981083 R identified by similarity to SP:P08372; match to protein family HMM TIGR02532; hypothetical protein complement(2980760..2981083) Escherichia coli HS 5594784 YP_001459594.1 CDS EcHS_A2970 NC_009800.1 2981068 2981475 R ygdB; identified by similarity to SP:P08370; hypothetical protein complement(2981068..2981475) Escherichia coli HS 5594785 YP_001459595.1 CDS ppdB NC_009800.1 2981472 2982035 R identified by similarity to SP:P08371; match to protein family HMM PF07963; match to protein family HMM TIGR02532; hypothetical protein complement(2981472..2982035) Escherichia coli HS 5594786 YP_001459596.1 CDS ppdA NC_009800.1 2982026 2982496 R identified by similarity to SP:P33554; match to protein family HMM PF07963; match to protein family HMM TIGR02532; hypothetical protein complement(2982026..2982496) Escherichia coli HS 5594420 YP_001459597.1 CDS thyA NC_009800.1 2982681 2983475 R ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase complement(2982681..2983475) Escherichia coli HS 5594421 YP_001459598.1 CDS lgt NC_009800.1 2983482 2984357 R transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase complement(2983482..2984357) Escherichia coli HS 5594422 YP_001459599.1 CDS ptsP NC_009800.1 2984508 2986754 R member of a second PTS chain involved in nitrogen metabolism; PtsP phosphorylates NPr; fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain complement(2984508..2986754) Escherichia coli HS 5594954 YP_001459600.1 CDS nudH NC_009800.1 2986767 2987297 R hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase complement(2986767..2987297) Escherichia coli HS 5594955 YP_001459601.1 CDS EcHS_A2977 NC_009800.1 2987650 2987796 R NULL; identified by glimmer; hypothetical protein complement(2987650..2987796) Escherichia coli HS 5594956 YP_001459602.1 CDS mutH NC_009800.1 2987982 2988671 D MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair; DNA mismatch repair protein 2987982..2988671 Escherichia coli HS 5595471 YP_001459603.1 CDS EcHS_A2979 NC_009800.1 2988740 2989453 D identified by match to protein family HMM PF03741; TerC family integral membrane protein 2988740..2989453 Escherichia coli HS 5595472 YP_001459604.1 CDS EcHS_A2980 NC_009800.1 2989591 2989809 D identified by similarity to GB:AAV78717.1; match to protein family HMM PF06004; lipoprotein 2989591..2989809 Escherichia coli HS 5595473 YP_001459605.1 CDS tas NC_009800.1 2989917 2990957 D complements the prephenate dehydrogenase dysfunction of an Escherichia coli tyrosine auxotroph strain; member of the aldo/keto reductase 2 family; crystal structure of purified Escherichia coli protein shows bound NADPH; aldo-keto reductase 2989917..2990957 Escherichia coli HS 5595491 YP_001459606.1 CDS lplT NC_009800.1 2990989 2992182 R identified by similarity to SP:P39196; match to protein family HMM PF07690; lysophospholipid transporter LplT complement(2990989..2992182) Escherichia coli HS 5595492 YP_001459607.1 CDS aas NC_009800.1 2992175 2994334 R Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase complement(2992175..2994334) Escherichia coli HS 5595493 YP_001459608.1 CDS galR NC_009800.1 2994920 2995951 D controls transcription of galETKM; DNA-binding transcriptional regulator GalR 2994920..2995951 Escherichia coli HS 5594946 YP_001459609.1 CDS lysA NC_009800.1 2995958 2997220 R catalyzes the decarboxylation of diaminopimelate into lysine; pyridoxal phosphate(PLP)-binding; diaminopimelate decarboxylase complement(2995958..2997220) Escherichia coli HS 5595459 YP_001459610.1 CDS lysR NC_009800.1 2997342 2998277 D activates the transcription of the lysA gene encoding diaminopimelate decarboxylase; LysR family transcriptional regulator 2997342..2998277 Escherichia coli HS 5595460 YP_001459611.1 CDS EcHS_A2987 NC_009800.1 2998264 2998956 R identified by match to protein family HMM PF01177; match to protein family HMM TIGR00035; racemase complement(2998264..2998956) Escherichia coli HS 5595461 YP_001459612.1 CDS araE NC_009800.1 2999085 3000503 R identified by match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM TIGR00879; arabinose-proton symporter complement(2999085..3000503) Escherichia coli HS 5595474 YP_001459613.1 CDS kduD NC_009800.1 3000818 3001579 R catalyzes the formation of 3-dehydro-2-deoxy-D-gluconate from 2-deoxy-D-gluconate; 2-deoxy-D-gluconate 3-dehydrogenase complement(3000818..3001579) Escherichia coli HS 5595475 YP_001459614.1 CDS kduI NC_009800.1 3001609 3002445 R 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate; 5-keto-4-deoxyuronate isomerase complement(3001609..3002445) Escherichia coli HS 5595476 YP_001459615.1 CDS EcHS_A2991 NC_009800.1 3002732 3003913 R Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis; acetyl-CoA acetyltransferase complement(3002732..3003913) Escherichia coli HS 5595477 YP_001459616.1 CDS EcHS_A2992 NC_009800.1 3004168 3005397 D identified by match to protein family HMM PF01490; match to protein family HMM TIGR00814; serine transporter family protein 3004168..3005397 Escherichia coli HS 5591215 YP_001459617.1 CDS EcHS_A2993 NC_009800.1 3005797 3006489 D yqeH; identified by similarity to GB:AAZ89600.1; hypothetical protein 3005797..3006489 Escherichia coli HS 5591216 YP_001459618.1 CDS EcHS_A2994 NC_009800.1 3006823 3007632 D identified by match to protein family HMM PF00486; transcriptional regulatory protein, C terminal 3006823..3007632 Escherichia coli HS 5591217 YP_001459619.1 CDS EcHS_A2995 NC_009800.1 3007714 3008106 D yqeJ; hypothetical protein 3007714..3008106 Escherichia coli HS 5594429 YP_001459620.1 CDS EcHS_A2996 NC_009800.1 3008139 3008279 R identified by glimmer; hypothetical protein complement(3008139..3008279) Escherichia coli HS 5594430 YP_001459621.1 CDS EcHS_A2997 NC_009800.1 3008820 3009056 R NULL; identified by glimmer; hypothetical protein complement(3008820..3009056) Escherichia coli HS 5594431 YP_001459622.1 CDS EcHS_A2998 NC_009800.1 3009110 3009556 D NULL; identified by glimmer; hypothetical protein 3009110..3009556 Escherichia coli HS 5595438 YP_001459623.1 CDS EcHS_A2999 NC_009800.1 3009823 3010314 D identified by match to protein family HMM PF07720; TPR repeat-containing protein 3009823..3010314 Escherichia coli HS 5595439 YP_001459624.1 CDS EcHS_A3000 NC_009800.1 3010649 3012025 D identified by match to protein family HMM PF00486; match to protein family HMM PF07719; transcriptional regulator 3010649..3012025 Escherichia coli HS 5595440 YP_001459625.1 CDS EcHS_A3002 NC_009800.1 3013014 3013646 R identified by match to protein family HMM PF00072; match to protein family HMM PF00196; LuxR family transcriptional regulator complement(3013014..3013646) Escherichia coli HS 5594891 YP_001459626.1 CDS EcHS_A3003 NC_009800.1 3013865 3014296 R identified by similarity to GB:AAA83039.1; hypothetical protein complement(3013865..3014296) Escherichia coli HS 5594892 YP_001459627.1 CDS EcHS_A3004 NC_009800.1 3014299 3014493 R identified by glimmer; hypothetical protein complement(3014299..3014493) Escherichia coli HS 5594851 YP_001459628.1 CDS EcHS_A3006 NC_009800.1 3015585 3015860 D identified by match to protein family HMM PF03811; IS1, transposase orfA 3015585..3015860 Escherichia coli HS 5594853 YP_001459629.1 CDS EcHS_A3007 NC_009800.1 3015779 3016282 D identified by match to protein family HMM PF03400; IS1, transposase orfB 3015779..3016282 Escherichia coli HS 5592920 YP_001459630.1 CDS eprJ NC_009800.1 3016616 3016948 R identified by similarity to SP:P41785; type III secretion apparatus protein EprJ complement(3016616..3016948) Escherichia coli HS 5592922 YP_001459631.1 CDS eprI NC_009800.1 3016968 3017183 R identified by match to protein family HMM TIGR02105; type III secretion apparatus needle protein complement(3016968..3017183) Escherichia coli HS 5594816 YP_001459632.1 CDS eprH NC_009800.1 3017221 3018402 R identified by similarity to GB:BAB60835.1; match to protein family HMM TIGR02554; type III secretion apparatus protein EprH complement(3017221..3018402) Escherichia coli HS 5594817 YP_001459633.1 CDS EcHS_A3012 NC_009800.1 3018660 3019160 D NULL; identified by match to protein family HMM PF00196; LuxR family transcriptional regulator 3018660..3019160 Escherichia coli HS 5594818 YP_001459634.1 CDS EcHS_A3013 NC_009800.1 3019162 3019437 D identified by similarity to SP:P37423; invasion lipoprotein 3019162..3019437 Escherichia coli HS 5594841 YP_001459635.1 CDS EcHS_A3014 NC_009800.1 3019517 3019879 R identified by similarity to SP:P40727; hypothetical protein complement(3019517..3019879) Escherichia coli HS 5594842 YP_001459636.1 CDS epaR NC_009800.1 3020645 3021412 R identified by similarity to GB:BAB60840.1; match to protein family HMM PF01311; match to protein family HMM TIGR01401; type III secretion apparatus protein EpaR complement(3020645..3021412) Escherichia coli HS 5593752 YP_001459637.1 CDS epaQ NC_009800.1 3021414 3021674 R identified by similarity to GB:BAB60841.1; match to protein family HMM PF01313; match to protein family HMM TIGR01403; type III secretion apparatus protein EpaQ complement(3021414..3021674) Escherichia coli HS 5593753 YP_001459638.1 CDS spaP NC_009800.1 3021684 3022349 R part of a type III secretory system probably involved in invasion into eukaryotic cells; surface presentation of antigens protein SpaP complement(3021684..3022349) Escherichia coli HS 5593754 YP_001459639.1 CDS epaO NC_009800.1 3022339 3023286 R involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells; surface presentation of antigens protein SpaO complement(3022339..3023286) Escherichia coli HS 5594445 YP_001459640.1 CDS EcHS_A3020 NC_009800.1 3023286 3023384 R identified by similarity to GB:BAB37150.1; type III secretion apparatus protein, truncation complement(3023286..3023384) Escherichia coli HS 5594446 YP_001459641.1 CDS EcHS_A3021 NC_009800.1 3023546 3024358 R identified by similarity to GB:AAP17067.1; match to protein family HMM PF00665; ISEhe3, transposase orfB complement(3023546..3024358) Escherichia coli HS 5594447 YP_001459642.1 CDS EcHS_A3022 NC_009800.1 3024415 3024693 R identified by match to protein family HMM PF01527; ISEhe3, transposase orfA complement(3024415..3024693) Escherichia coli HS 5594657 YP_001459643.1 CDS EcHS_A3023 NC_009800.1 3024716 3026302 R hypothetical protein complement(3024716..3026302) Escherichia coli HS 5594658 YP_001459644.1 CDS EcHS_A3025 NC_009800.1 3026650 3027405 R identified by match to protein family HMM PF01476; match to protein family HMM PF01551; M23B family peptidase complement(3026650..3027405) Escherichia coli HS 5594660 YP_001459645.1 CDS xdhA NC_009800.1 3027820 3030117 D molybdenum cofactor-binding protein; participates in purine salvage; xanthine dehydrogenase subunit XdhA 3027820..3030117 Escherichia coli HS 5594661 YP_001459646.1 CDS xdhB NC_009800.1 3030128 3031006 D FAD-binding subunit; with XdhA and XdhC participates in purine salvage; xanthine dehydrogenase subunit XdhB 3030128..3031006 Escherichia coli HS 5594727 YP_001459647.1 CDS xdhC NC_009800.1 3031003 3031482 D iron-sulfur-binding subunit; with XdhA and XdhB participates in purine salvage; xanthine dehydrogenase subunit XdhC 3031003..3031482 Escherichia coli HS 5594728 YP_001459648.1 CDS EcHS_A3029 NC_009800.1 3031522 3033300 R identified by match to protein family HMM PF00158; match to protein family HMM PF02954; sigma-54 dependent trancsriptional regulator complement(3031522..3033300) Escherichia coli HS 5594729 YP_001459649.1 CDS EcHS_A3030 NC_009800.1 3033776 3034966 D ygeW; identified by match to protein family HMM PF00185; match to protein family HMM PF02729; match to protein family HMM TIGR03316; aspartate/ornithine carbamoyltransferase 3033776..3034966 Escherichia coli HS 5594626 YP_001459650.1 CDS EcHS_A3031 NC_009800.1 3035024 3036220 D catalyzes the formation of pyruvate from 2,3-diaminopropionate; diaminopropionate ammonia-lyase 3035024..3036220 Escherichia coli HS 5594627 YP_001459651.1 CDS EcHS_A3032 NC_009800.1 3036278 3037489 D Zn-dependent extracellular dipeptidase; similar to succinyl-diaminopimelate desuccinylases; peptidase 3036278..3037489 Escherichia coli HS 5594628 YP_001459652.1 CDS hyuA NC_009800.1 3037542 3038927 D catalyzes the hydrolytic cleavage of hydantoin with aromatic side chains at the 5'position; phenylhydantoinase 3037542..3038927 Escherichia coli HS 5594358 YP_001459653.1 CDS EcHS_A3034 NC_009800.1 3038975 3039907 D catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 3038975..3039907 Escherichia coli HS 5594359 YP_001459654.1 CDS EcHS_A3035 NC_009800.1 3040128 3041753 R identified by match to protein family HMM PF00364; match to protein family HMM PF02625; match to protein family HMM TIGR03309; xanthine dehydrogenase accessory factor complement(3040128..3041753) Escherichia coli HS 5594360 YP_001459655.1 CDS EcHS_A3036 NC_009800.1 3041801 3042571 R yqeC; identified by similarity to SP:Q46809; match to protein family HMM TIGR03172; hypothetical protein complement(3041801..3042571) Escherichia coli HS 5593546 YP_001459656.1 CDS EcHS_A3037 NC_009800.1 3042674 3043252 D identified by similarity to SP:Q46810; match to protein family HMM TIGR03310; hypothetical protein 3042674..3043252 Escherichia coli HS 5593547 YP_001459657.1 CDS EcHS_A3038 NC_009800.1 3043574 3046672 D with YgfM and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfK mutants are unable to reduce selenate; involved in purine salvage process; seems to act as an oxidoreductase, but sequence similarity suggests it is a dihydrothymine dehydrogenase; selenate reductase subunit YgfK 3043574..3046672 Escherichia coli HS 5593548 YP_001459658.1 CDS ssnA NC_009800.1 3046675 3048003 D in Escherichia coli expression is induced in response to phase-specific signals and controlled by RpoS; chlorohydrolase/aminohydrolase 3046675..3048003 Escherichia coli HS 5594282 YP_001459659.1 CDS EcHS_A3040 NC_009800.1 3048054 3048833 D with YgfK and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfM contains a FAD domain; selenate reductase subunit YgfM 3048054..3048833 Escherichia coli HS 5594283 YP_001459660.1 CDS EcHS_A3041 NC_009800.1 3048830 3051700 D with YgfK and YgfM forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; molybdopterin-containing enzyme; oxidase activity toward hypoxanthine and xanthine can be detected if these substrates are present at high concentration; selenate reductase subunit YgfN 3048830..3051700 Escherichia coli HS 5594284 YP_001459661.1 CDS EcHS_A3042 NC_009800.1 3051865 3053265 D identified by match to protein family HMM PF00860; match to protein family HMM TIGR00801; match to protein family HMM TIGR03173; xanthine/uracil permease 3051865..3053265 Escherichia coli HS 5594216 YP_001459662.1 CDS guaD NC_009800.1 3053283 3054599 D Catalyzes the deamination of guanine; guanine deaminase 3053283..3054599 Escherichia coli HS 5594217 YP_001459663.1 CDS EcHS_A3044 NC_009800.1 3054635 3056002 D ygfQ; identified by match to protein family HMM PF00860; match to protein family HMM PF00916; sulfate permease inorganic anion transporter 3054635..3056002 Escherichia coli HS 5594218 YP_001459664.1 CDS EcHS_A3045 NC_009800.1 3056038 3056526 R identified by match to protein family HMM PF00037; (4Fe-4S)-binding protein complement(3056038..3056526) Escherichia coli HS 5594043 YP_001459665.1 CDS aegA2 NC_009800.1 3056526 3058445 R unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic); oxidoreductase Fe-S binding subunit complement(3056526..3058445) Escherichia coli HS 5594044 YP_001459666.1 CDS EcHS_A3047 NC_009800.1 3058881 3060329 D identified by match to protein family HMM PF00860; match to protein family HMM TIGR00801; match to protein family HMM TIGR03173; xanthine permease 3058881..3060329 Escherichia coli HS 5594045 YP_001459667.1 CDS idi NC_009800.1 3060579 3061127 D catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate; isopentenyl-diphosphate delta-isomerase 3060579..3061127 Escherichia coli HS 5592153 YP_001459668.1 CDS lysS NC_009800.1 3061170 3062687 R class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase complement(3061170..3062687) Escherichia coli HS 5592154 YP_001459669.1 CDS prfB NC_009800.1 3062697 3063795 R recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 complement(join(3062697..3063717,3063719..3063795)) Escherichia coli HS 5592155 YP_001459670.1 CDS recJ NC_009800.1 3063886 3065619 R 5'-3' single-stranded-DNA-specific exonuclease; ssDNA exonuclease RecJ complement(3063886..3065619) Escherichia coli HS 5594654 YP_001459671.1 CDS dsbC NC_009800.1 3065625 3066335 R DsbC; periplasmic protein with protein disulfide isomerase activity; this protein also shows disulfide oxidoreductase activity; thiol:disulfide interchange protein DsbC complement(3065625..3066335) Escherichia coli HS 5594655 YP_001459672.1 CDS xerD NC_009800.1 3066360 3067256 R site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD complement(3066360..3067256) Escherichia coli HS 5594656 YP_001459673.1 CDS fldB NC_009800.1 3067368 3067889 D An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic; flavodoxin FldB 3067368..3067889 Escherichia coli HS 5595327 YP_001459674.1 CDS EcHS_A3055 NC_009800.1 3067929 3068336 R ygfX; identified by match to protein family HMM PF07254; hypothetical protein complement(3067929..3068336) Escherichia coli HS 5595328 YP_001459675.1 CDS EcHS_A3056 NC_009800.1 3068558 3068749 D identified by similarity to GB:AAN81926.1; hypothetical protein 3068558..3068749 Escherichia coli HS 5595329 YP_001459676.1 CDS ygfZ NC_009800.1 3068826 3069806 D physiological role is not clear; not essential for growth but mutants grow poorly; mutations suppress hda null mutations; may be involved in regulation of ATP-DnaA levels; may also be involved in regulation of tRNA modifications; can bind folic acid and tetrahydrofolate; forms a three domain ring-like structure with a central channel; structurally similar to DMGO protein from A. globiformis; shows sequence similarity to yeast CAF17 transcriptional regulator; global regulator 3068826..3069806 Escherichia coli HS 5594485 YP_001459677.1 CDS EcHS_A3058 NC_009800.1 3070002 3070661 R identified by match to protein family HMM PF03006; match to protein family HMM TIGR01065; hemolysin III family channel protein complement(3070002..3070661) Escherichia coli HS 5594486 YP_001459678.1 CDS EcHS_A3059 NC_009800.1 3070825 3071136 R yqfB; identified by match to protein family HMM PF06164; hypothetical protein complement(3070825..3071136) Escherichia coli HS 5594487 YP_001459679.1 CDS bglA NC_009800.1 3071175 3072614 D identified by similarity to SP:Q46829; match to protein family HMM PF00232; 6-phospho-beta-glucosidase 3071175..3072614 Escherichia coli HS 5593940 YP_001459680.1 CDS EcHS_A3061 NC_009800.1 3072671 3073414 R identified by match to protein family HMM PF00106; match to protein family HMM PF01370; match to protein family HMM PF08659; hypothetical protein complement(3072671..3073414) Escherichia coli HS 5593941 YP_001459681.1 CDS gcvP NC_009800.1 3073680 3076553 R acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase complement(3073680..3076553) Escherichia coli HS 5593942 YP_001459682.1 CDS gcvH NC_009800.1 3076672 3077061 R part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor; glycine cleavage system protein H complement(3076672..3077061) Escherichia coli HS 5594352 YP_001459683.1 CDS gcvT NC_009800.1 3077085 3078179 R catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T complement(3077085..3078179) Escherichia coli HS 5594353 YP_001459684.1 CDS EcHS_A3065 NC_009800.1 3078626 3079828 R visC; identified by match to protein family HMM PF01266; match to protein family HMM PF01494; match to protein family HMM TIGR01988; hypothetical protein complement(3078626..3079828) Escherichia coli HS 5594354 YP_001459685.1 CDS ubiH NC_009800.1 3079851 3081029 R Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone; 2-octaprenyl-6-methoxyphenyl hydroxylase complement(3079851..3081029) Escherichia coli HS 5592844 YP_001459686.1 CDS pepP NC_009800.1 3081026 3082351 R exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue; substrate can be as short as a dipeptide; proline aminopeptidase P II complement(3081026..3082351) Escherichia coli HS 5592845 YP_001459687.1 CDS EcHS_A3068 NC_009800.1 3082377 3082955 R the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown; hypothetical protein complement(3082377..3082955) Escherichia coli HS 5592846 YP_001459688.1 CDS EcHS_A3069 NC_009800.1 3083123 3083452 D ygfE; identified by match to protein family HMM PF05164; Z-ring-associated protein 3083123..3083452 Escherichia coli HS 5595262 YP_001459689.2 CDS EcHS_A3070 NC_009800.1 3083752 3084300 D ygfA expression increases five to eight fold in Escherichia coli cells growing as biofilms; unknown function; ligase 3083752..3084300 Escherichia coli HS 5595264 YP_001459690.1 CDS serA NC_009800.1 3084689 3085921 R catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase complement(3084689..3085921) Escherichia coli HS 5594362 YP_001459691.1 CDS rpiA NC_009800.1 3086177 3086836 R Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A complement(3086177..3086836) Escherichia coli HS 5593995 YP_001459692.1 CDS EcHS_A3073 NC_009800.1 3086892 3087122 R yqfE; identified by similarity to SP:P64562; hypothetical protein complement(3086892..3087122) Escherichia coli HS 5593996 YP_001459693.1 CDS iciA NC_009800.1 3087264 3088157 D specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport; chromosome replication initiation inhibitor protein 3087264..3088157 Escherichia coli HS 5593997 YP_001459694.1 CDS msm NC_009800.1 3088361 3090505 D MDM; functions in conversion of succinate to propionate; methylmalonyl-CoA mutase 3088361..3090505 Escherichia coli HS 5594128 YP_001459695.1 CDS EcHS_A3076 NC_009800.1 3090498 3091493 D functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins; arginine/ornithine transport system ATPase 3090498..3091493 Escherichia coli HS 5594129 YP_001459696.1 CDS EcHS_A3077 NC_009800.1 3091504 3092289 D catalyzes the formation of propanoyl-CoA from methylmalonyl-CoA; methylmalonyl-CoA decarboxylase 3091504..3092289 Escherichia coli HS 5594130 YP_001459697.1 CDS EcHS_A3078 NC_009800.1 3092313 3093791 D identified by match to protein family HMM PF02550; acetyl-CoA hydrolase/transferase 3092313..3093791 Escherichia coli HS 5595259 YP_001459698.1 CDS EcHS_A3079 NC_009800.1 3093788 3094684 R identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator complement(3093788..3094684) Escherichia coli HS 5595260 YP_001459699.1 CDS EcHS_A3080 NC_009800.1 3094851 3095591 R identified by similarity to SP:P0ADS8; match to protein family HMM PF04402; hypothetical protein complement(3094851..3095591) Escherichia coli HS 5595261 YP_001459700.1 CDS argO NC_009800.1 3095684 3096319 R Involved in the export of arginine; arginine exporter protein complement(3095684..3096319) Escherichia coli HS 5594228 YP_001459701.1 CDS mscS NC_009800.1 3096458 3097318 R participates in the regulation of osmotic pressure changes within the cel; mechanosensitive channel MscS complement(3096458..3097318) Escherichia coli HS 5594229 YP_001459702.1 CDS fbaA NC_009800.1 3097676 3098755 R catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase complement(3097676..3098755) Escherichia coli HS 5594230 YP_001459703.1 CDS pgk NC_009800.1 3098970 3100133 R Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase complement(3098970..3100133) Escherichia coli HS 5593968 YP_001459704.1 CDS epd NC_009800.1 3100183 3101202 R NAD-dependent; catalyzes the formation of 4-phosphoerythronate from erythrose 4-phosphate in the biosynthesis of pyridoxine 5'-phosphate; erythrose 4-phosphate dehydrogenase complement(3100183..3101202) Escherichia coli HS 5593969 YP_001459705.1 CDS frcK NC_009800.1 3101487 3102200 R identified by similarity to SP:P11664; fructose transport system kinase complement(3101487..3102200) Escherichia coli HS 5593970 YP_001459706.1 CDS EcHS_A3087 NC_009800.1 3102197 3102706 R yggD; identified by match to protein family HMM PF05068; DNA-binding transcriptional regulator complement(3102197..3102706) Escherichia coli HS 5594142 YP_001459707.1 CDS glpX2 NC_009800.1 3102728 3103693 R identified by match to protein family HMM PF03320; match to protein family HMM TIGR00330; fructose-1,6-bisphosphatase II-like protein complement(3102728..3103693) Escherichia coli HS 5594143 YP_001459708.1 CDS sorE NC_009800.1 3103690 3104967 R yggP; identified by similarity to SP:P37084; match to protein family HMM PF00107; match to protein family HMM PF08240; L-sorbose 1-phosphate reductase complement(3103690..3104967) Escherichia coli HS 5594144 YP_001459709.1 CDS EcHS_A3090 NC_009800.1 3104982 3106205 R identified by match to protein family HMM PF02302; match to protein family HMM PF02378; PTS system, mannitol-specific cryptic EIICB component, truncation complement(3104982..3106205) Escherichia coli HS 5593241 YP_001459710.1 CDS EcHS_A3091 NC_009800.1 3106287 3106790 R identified by match to protein family HMM PF03400; IS1, transposase orfB complement(3106287..3106790) Escherichia coli HS 5593242 YP_001459711.1 CDS EcHS_A3092 NC_009800.1 3106709 3106984 R identified by match to protein family HMM PF03811; IS1, transposase orfA complement(3106709..3106984) Escherichia coli HS 5593243 YP_001459712.1 CDS tkt NC_009800.1 3107271 3109262 R catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase complement(3107271..3109262) Escherichia coli HS 5593908 YP_001459713.1 CDS EcHS_A3094 NC_009800.1 3109540 3110298 D yggG; identified by match to protein family HMM PF01435; M48B family peptidase 3109540..3110298 Escherichia coli HS 5593909 YP_001459714.1 CDS speB NC_009800.1 3110504 3111424 R catalyzes the formation of putrescine from agmatine; agmatinase complement(3110504..3111424) Escherichia coli HS 5593910 YP_001459715.1 CDS speA NC_009800.1 3111562 3113538 R catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis; arginine decarboxylase complement(3111562..3113538) Escherichia coli HS 5595215 YP_001459716.1 CDS EcHS_A3097 NC_009800.1 3113547 3113693 R yqgB; identified by similarity to GB:AAP18236.1; hypothetical protein complement(3113547..3113693) Escherichia coli HS 5595216 YP_001459717.1 CDS EcHS_A3098 NC_009800.1 3114013 3114138 D identified by glimmer; hypothetical protein 3114013..3114138 Escherichia coli HS 5595217 YP_001459718.1 CDS metK NC_009800.1 3114333 3115487 D catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 3114333..3115487 Escherichia coli HS 5593943 YP_001459719.1 CDS EcHS_A3100 NC_009800.1 3115550 3115684 D identified by glimmer; hypothetical protein 3115550..3115684 Escherichia coli HS 5593944 YP_001459720.1 CDS galP NC_009800.1 3115923 3117317 D identified by match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM TIGR00879; galactose-proton symporter 3115923..3117317 Escherichia coli HS 5593945 YP_001459721.1 CDS sprT NC_009800.1 3117394 3117891 D sprT; identified by match to protein family HMM PF03926; hypothetical protein 3117394..3117891 Escherichia coli HS 5593549 YP_001459722.1 CDS endA NC_009800.1 3117986 3118693 D identified by similarity to SP:P25736; match to protein family HMM PF04231; endonuclease I 3117986..3118693 Escherichia coli HS 5593550 YP_001459723.1 CDS EcHS_A3104 NC_009800.1 3118773 3119504 D in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 3118773..3119504 Escherichia coli HS 5593551 YP_001459724.1 CDS gshB NC_009800.1 3119517 3120467 D The second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione; glutathione synthetase 3119517..3120467 Escherichia coli HS 5593833 YP_001459725.1 CDS EcHS_A3106 NC_009800.1 3120576 3121139 D yqgE; identified by similarity to SP:P0A8W7; match to protein family HMM PF02622; hypothetical protein 3120576..3121139 Escherichia coli HS 5593834 YP_001459726.1 CDS EcHS_A3107 NC_009800.1 3121139 3121555 D similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 3121139..3121555 Escherichia coli HS 5593835 YP_001459727.1 CDS EcHS_A3108 NC_009800.1 3121562 3121690 R identified by glimmer; hypothetical protein complement(3121562..3121690) Escherichia coli HS 5593905 YP_001459728.1 CDS EcHS_A3109 NC_009800.1 3121811 3122791 R identified by match to protein family HMM PF01548; match to protein family HMM PF02371; IS621, transposase complement(3121811..3122791) Escherichia coli HS 5593906 YP_001459729.1 CDS EcHS_A3110 NC_009800.1 3123018 3123998 R identified by match to protein family HMM PF00437; match to protein family HMM TIGR01420; twitching motility family protein complement(3123018..3123998) Escherichia coli HS 5593907 YP_001459730.1 CDS EcHS_A3111 NC_009800.1 3124016 3124720 D yggS; identified by match to protein family HMM PF01168; match to protein family HMM TIGR00044; alanine racemase 3124016..3124720 Escherichia coli HS 5593377 YP_001459731.1 CDS EcHS_A3112 NC_009800.1 3124738 3125304 D identified by match to protein family HMM PF02325; hypothetical protein 3124738..3125304 Escherichia coli HS 5593378 YP_001459732.1 CDS EcHS_A3113 NC_009800.1 3125289 3125591 D yggU; identified by similarity to GB:AAP18250.1; match to protein family HMM PF02594; match to protein family HMM TIGR00251; hypothetical protein 3125289..3125591 Escherichia coli HS 5593379 YP_001459733.1 CDS rdgB NC_009800.1 3125599 3126192 D HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase 3125599..3126192 Escherichia coli HS 5593948 YP_001459734.1 CDS EcHS_A3115 NC_009800.1 3126185 3127321 D catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 3126185..3127321 Escherichia coli HS 5593949 YP_001459735.1 CDS EcHS_A3116 NC_009800.1 3127476 3128483 R identified by match to protein family HMM PF06717; hypothetical protein complement(3127476..3128483) Escherichia coli HS 5593950 YP_001459736.1 CDS ansB NC_009800.1 3128600 3129646 R catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis; L-asparaginase II complement(3128600..3129646) Escherichia coli HS 5593714 YP_001459737.1 CDS EcHS_A3118 NC_009800.1 3129822 3130538 R yggN; identified by similarity to SP:P0ADS9; hypothetical protein complement(3129822..3130538) Escherichia coli HS 5593715 YP_001459738.1 CDS EcHS_A3119 NC_009800.1 3130562 3130702 R identified by similarity to GB:AAN81993.1; hypothetical protein complement(3130562..3130702) Escherichia coli HS 5593716 YP_001459739.1 CDS EcHS_A3120 NC_009800.1 3130725 3131051 R yggL; identified by match to protein family HMM PF04320; hypothetical protein complement(3130725..3131051) Escherichia coli HS 5593176 YP_001459740.1 CDS trmB NC_009800.1 3131051 3131770 R tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase complement(3131051..3131770) Escherichia coli HS 5593177 YP_001459741.1 CDS mutY NC_009800.1 3131901 3132983 D identified by match to protein family HMM PF00633; match to protein family HMM PF00730; match to protein family HMM TIGR01084; adenine DNA glycosylase 3131901..3132983 Escherichia coli HS 5593178 YP_001459742.1 CDS EcHS_A3123 NC_009800.1 3132960 3133253 R identified by similarity to GB:AAN81997.1; hypothetical protein complement(3132960..3133253) Escherichia coli HS 5595209 YP_001459743.1 CDS mltC NC_009800.1 3133351 3134430 D Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase C 3133351..3134430 Escherichia coli HS 5595210 YP_001459744.1 CDS nupG NC_009800.1 3134632 3135888 D identified by similarity to SP:P09452; match to protein family HMM PF03825; match to protein family HMM PF07690; match to protein family HMM TIGR00889; nucleoside permease NupG 3134632..3135888 Escherichia coli HS 5595211 YP_001459745.1 CDS speC NC_009800.1 3135938 3138073 R identified by match to protein family HMM PF01276; match to protein family HMM PF03709; match to protein family HMM PF03711; ornithine decarboxylase complement(3135938..3138073) Escherichia coli HS 5593852 YP_001459746.1 CDS EcHS_A3127 NC_009800.1 3138472 3139179 D identified by match to protein family HMM PF04474; hypothetical protein 3138472..3139179 Escherichia coli HS 5593853 YP_001459747.1 CDS gspM NC_009800.1 3139509 3140045 R identified by similarity to SP:P41851; match to protein family HMM PF04612; general secretion pathway protein YghD complement(3139509..3140045) Escherichia coli HS 5593850 YP_001459748.1 CDS gspL2 NC_009800.1 3140047 3141225 R similar to general secretory pathway protein L; GspL-like protein complement(3140047..3141225) Escherichia coli HS 5593851 YP_001459749.1 CDS gspK NC_009800.1 3141222 3142199 R identified by match to protein family HMM PF03934; general secretion pathway protein K complement(3141222..3142199) Escherichia coli HS 5593643 YP_001459750.1 CDS gspJ2 NC_009800.1 3142196 3142801 R identified by match to protein family HMM PF07963; match to protein family HMM TIGR01711; match to protein family HMM TIGR02532; general secretion pathway protein J complement(3142196..3142801) Escherichia coli HS 5593644 YP_001459751.1 CDS gspI2 NC_009800.1 3142798 3143169 R identified by match to protein family HMM PF02501; match to protein family HMM PF07963; match to protein family HMM TIGR01707; match to protein family HMM TIGR02532; general secretion pathway protein I complement(3142798..3143169) Escherichia coli HS 5593645 YP_001459752.1 CDS gspH2 NC_009800.1 3143166 3143729 R identified by match to protein family HMM PF07963; match to protein family HMM TIGR01708; match to protein family HMM TIGR02532; general secretion pathway protein H complement(3143166..3143729) Escherichia coli HS 5595253 YP_001459753.1 CDS gspG2 NC_009800.1 3143733 3144188 R identified by match to protein family HMM PF07963; match to protein family HMM PF08334; match to protein family HMM TIGR01710; match to protein family HMM TIGR02532; general secretion pathway protein G complement(3143733..3144188) Escherichia coli HS 5595254 YP_001459754.1 CDS gspF2 NC_009800.1 3144205 3145428 R identified by match to protein family HMM PF00482; match to protein family HMM TIGR02120; general secretion pathway protein F complement(3144205..3145428) Escherichia coli HS 5595255 YP_001459755.1 CDS gspE2 NC_009800.1 3145428 3146921 R identified by match to protein family HMM PF00437; match to protein family HMM TIGR02533; general secretory pathway protein E complement(3145428..3146921) Escherichia coli HS 5593799 YP_001459756.1 CDS gspD2 NC_009800.1 3146921 3148981 R identified by match to protein family HMM PF00263; match to protein family HMM PF03958; match to protein family HMM TIGR02517; general secretion pathway protein D complement(3146921..3148981) Escherichia coli HS 5593800 YP_001459757.1 CDS gspC1 NC_009800.1 3149011 3149970 R part of the general (type II) secretion pathway (GSP), a signal sequence-dependent process responsible for protein export; involved in trans-location of exoproteins from the cytoplasm to the periplasm; type II secretion protein GspC complement(3149011..3149970) Escherichia coli HS 5593801 YP_001459758.1 CDS EcHS_A3140 NC_009800.1 3149988 3150398 R yghG; lipoprotein complement(3149988..3150398) Escherichia coli HS 5591926 YP_001459759.1 CDS EcHS_A3141 NC_009800.1 3150464 3151273 R identified by similarity to SP:P31712; match to protein family HMM PF01478; match to protein family HMM PF06750; type IV prepilin peptidase complement(3150464..3151273) Escherichia coli HS 5591927 YP_001459760.1 CDS EcHS_A3142 NC_009800.1 3151413 3155924 R identified by similarity to GB:BAC62719.1; hypothetical protein complement(3151413..3155924) Escherichia coli HS 5591928 YP_001459761.1 CDS EcHS_A3143 NC_009800.1 3156120 3156302 D hypothetical protein 3156120..3156302 Escherichia coli HS 5593564 YP_001459762.1 CDS EcHS_A3144 NC_009800.1 3156395 3156670 D identified by match to protein family HMM PF03811; IS1, transposase orfA 3156395..3156670 Escherichia coli HS 5593565 YP_001459763.1 CDS EcHS_A3145 NC_009800.1 3156589 3157092 D identified by match to protein family HMM PF03400; IS1, transposase orfB 3156589..3157092 Escherichia coli HS 5593566 YP_001459764.1 CDS EcHS_A3146 NC_009800.1 3157103 3157216 R identified by glimmer; hypothetical protein complement(3157103..3157216) Escherichia coli HS 5593743 YP_001459765.1 CDS glcA NC_009800.1 3157231 3158913 R identified by match to protein family HMM PF02652; match to protein family HMM TIGR00795; glycolate transporter complement(3157231..3158913) Escherichia coli HS 5593744 YP_001459766.1 CDS glcB NC_009800.1 3159268 3161439 R catalyzes the formation of malate from glyoxylate and acetyl-CoA; malate synthase G complement(3159268..3161439) Escherichia coli HS 5593708 YP_001459767.1 CDS EcHS_A3149 NC_009800.1 3161461 3161865 R identified by similarity to SP:P45504; match to protein family HMM PF03928; hypothetical protein complement(3161461..3161865) Escherichia coli HS 5593709 YP_001459768.1 CDS glcF NC_009800.1 3161870 3163093 R identified by similarity to SP:P52074; match to protein family HMM PF00037; match to protein family HMM PF02754; glycolate oxidase iron-sulfur subunit complement(3161870..3163093) Escherichia coli HS 5593710 YP_001459769.1 CDS glcE NC_009800.1 3163104 3164156 R identified by match to protein family HMM PF01565; glycolate oxidase FAD binding subunit complement(3163104..3164156) Escherichia coli HS 5595187 YP_001459770.1 CDS glcD NC_009800.1 3164156 3165646 R identified by similarity to SP:P52075; match to protein family HMM PF01565; match to protein family HMM PF02913; match to protein family HMM TIGR00387; glycolate oxidase subunit GlcD complement(3164156..3165646) Escherichia coli HS 5595188 YP_001459771.1 CDS glcC NC_009800.1 3165906 3166670 D identified by similarity to SP:P0ACL5; match to protein family HMM PF00392; match to protein family HMM PF07729; DNA-binding transcriptional regulator GlcC 3165906..3166670 Escherichia coli HS 5595189 YP_001459772.1 CDS EcHS_A3154 NC_009800.1 3166677 3167819 R identified by glimmer; hypothetical protein complement(3166677..3167819) Escherichia coli HS 5593624 YP_001459773.1 CDS EcHS_A3155 NC_009800.1 3168187 3169917 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 3168187..3169917 Escherichia coli HS 5593625 YP_001459774.1 CDS EcHS_A3156 NC_009800.1 3169914 3170828 D identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF04321; match to protein family HMM PF05368; match to protein family HMM PF07993; match to protein family HMM PF08659; NAD dependent epimerase/dehydratase 3169914..3170828 Escherichia coli HS 5593626 YP_001459775.1 CDS EcHS_A3157 NC_009800.1 3170860 3171108 D identified by match to protein family HMM PF00550; acyl carrier protein 3170860..3171108 Escherichia coli HS 5593629 YP_001459776.1 CDS EcHS_A3158 NC_009800.1 3171108 3172280 D identified by similarity to GB:BAB56013.1; match to protein family HMM PF00155; match to protein family HMM PF00202; serine palmitoyltransferase 3171108..3172280 Escherichia coli HS 5593630 YP_001459777.1 CDS EcHS_A3159 NC_009800.1 3172316 3173395 R identified by match to protein family HMM PF03739; YjgP/YjgQ permease complement(3172316..3173395) Escherichia coli HS 5593631 YP_001459778.1 CDS EcHS_A3160 NC_009800.1 3173392 3174462 R identified by match to protein family HMM PF03739; YjgP/YjgQ permease complement(3173392..3174462) Escherichia coli HS 5592878 YP_001459779.1 CDS EcHS_A3161 NC_009800.1 3174493 3175053 R identified by match to protein family HMM TIGR01626; hypothetical protein complement(3174493..3175053) Escherichia coli HS 5592879 YP_001459780.1 CDS EcHS_A3162 NC_009800.1 3175065 3175889 R hypothetical protein complement(3175065..3175889) Escherichia coli HS 5592880 YP_001459781.1 CDS EcHS_A3163 NC_009800.1 3175889 3177238 R yghQ; identified by match to protein family HMM PF01943; polysaccharide biosynthesis protein complement(3175889..3177238) Escherichia coli HS 5593668 YP_001459782.1 CDS EcHS_A3164 NC_009800.1 3177284 3178042 R identified by similarity to GB:AAV89941.1; hypothetical protein complement(3177284..3178042) Escherichia coli HS 5593669 YP_001459783.1 CDS EcHS_A3165 NC_009800.1 3178074 3178787 R lipoprotein complement(3178074..3178787) Escherichia coli HS 5593670 YP_001459784.1 CDS EcHS_A3166 NC_009800.1 3178961 3179653 D identified by similarity to GB:AAV89942.1; hypothetical protein 3178961..3179653 Escherichia coli HS 5593658 YP_001459785.1 CDS pitB NC_009800.1 3179702 3181201 R identified by match to protein family HMM PF01384; low-affinity inorganic phosphate transporter 2 complement(3179702..3181201) Escherichia coli HS 5593659 YP_001459786.1 CDS gsp NC_009800.1 3181493 3183352 R catalyzes the formation of glutathionylspermidine from glutathione and spermidine; also catalyzes the reverse reaction; bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase complement(3181493..3183352) Escherichia coli HS 5593660 YP_001459787.1 CDS EcHS_A3169 NC_009800.1 3183557 3184423 D YghU; B2989; one of eight glutathione transferases from E. coli; glutathione S-transferase YghU 3183557..3184423 Escherichia coli HS 5593661 YP_001459788.1 CDS hybG NC_009800.1 3184546 3184794 R identified by match to protein family HMM PF01455; match to protein family HMM TIGR00074; hydrogenase 2 accessory protein HypG complement(3184546..3184794) Escherichia coli HS 5593662 YP_001459789.1 CDS hypA1 NC_009800.1 3184807 3185148 R plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein HybF complement(3184807..3185148) Escherichia coli HS 5593663 YP_001459790.1 CDS hybE NC_009800.1 3185141 3185629 R identified by similarity to SP:P0AAN1; hydrogenase 2-specific chaperone complement(3185141..3185629) Escherichia coli HS 5593460 YP_001459791.1 CDS hybD NC_009800.1 3185622 3186116 R protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC); hydrogenase 2 maturation endopeptidase complement(3185622..3186116) Escherichia coli HS 5593461 YP_001459792.1 CDS hybC NC_009800.1 3186116 3187819 R involved in hydrogen uptake; hydrogenase 2 large subunit complement(3186116..3187819) Escherichia coli HS 5593462 YP_001459793.1 CDS hybB NC_009800.1 3187816 3188994 R HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits; hydrogenase 2 b cytochrome subunit complement(3187816..3188994) Escherichia coli HS 5593469 YP_001459794.1 CDS hybA NC_009800.1 3188984 3189970 R Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2; hydrogenase 2 protein HybA complement(3188984..3189970) Escherichia coli HS 5593470 YP_001459795.1 CDS hyb0 NC_009800.1 3189973 3191091 R involved in hydrogen uptake; hydrogenase 2 small subunit complement(3189973..3191091) Escherichia coli HS 5593471 YP_001459796.1 CDS EcHS_A3178 NC_009800.1 3191280 3191567 R yghW; identified by similarity to SP:P64577; hypothetical protein complement(3191280..3191567) Escherichia coli HS 5592892 YP_001459797.1 CDS EcHS_A3180 NC_009800.1 3192728 3193768 D identified by match to protein family HMM PF00248; aldo/keto reductase 3192728..3193768 Escherichia coli HS 5592894 YP_001459798.1 CDS EcHS_A3181 NC_009800.1 3193808 3194302 R yqhA; identified by match to protein family HMM PF03350; match to protein family HMM TIGR00645; hypothetical protein complement(3193808..3194302) Escherichia coli HS 5593571 YP_001459799.1 CDS EcHS_A3182 NC_009800.1 3194493 3195377 D identified by match to protein family HMM PF00106; oxidoreductase 3194493..3195377 Escherichia coli HS 5593572 YP_001459800.1 CDS EcHS_A3183 NC_009800.1 3195450 3195641 R identified by glimmer; hypothetical protein complement(3195450..3195641) Escherichia coli HS 5593573 YP_001459801.1 CDS exbD NC_009800.1 3195649 3196074 R membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbD complement(3195649..3196074) Escherichia coli HS 5595134 YP_001459802.1 CDS exbB NC_009800.1 3196081 3196815 R membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbB complement(3196081..3196815) Escherichia coli HS 5595135 YP_001459803.1 CDS metC NC_009800.1 3197067 3198254 D catalyzes the formation of L-homocysteine from cystathionine; cystathionine beta-lyase 3197067..3198254 Escherichia coli HS 5595136 YP_001459804.1 CDS EcHS_A3187 NC_009800.1 3198394 3199053 D yghB; identified by similarity to SP:P0AA60; match to protein family HMM PF09335; hypothetical protein 3198394..3199053 Escherichia coli HS 5593099 YP_001459805.1 CDS EcHS_A3189 NC_009800.1 3199093 3200049 R identified by match to protein family HMM PF00165; match to protein family HMM PF06719; AraC family transcriptional regulator complement(3199093..3200049) Escherichia coli HS 5593100 YP_001459806.1 CDS yqhD NC_009800.1 3200186 3201349 D identified by similarity to SP:Q46856; match to protein family HMM PF00465; alcohol dehydrogenase 3200186..3201349 Escherichia coli HS 5593101 YP_001459807.1 CDS dkgA NC_009800.1 3201454 3202281 D methylglyoxal reductase/#-keto ester reductase; catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; also catalyzes the reduction of methylglyoxal, ethyl-2-methylacetoacetate and ethyl-acetoacetate; 2,5-diketo-D-gluconate reductase A 3201454..3202281 Escherichia coli HS 5593423 YP_001459808.1 CDS EcHS_A3192 NC_009800.1 3202481 3203407 D identified by glimmer; hypothetical protein 3202481..3203407 Escherichia coli HS 5593424 YP_001459809.1 CDS EcHS_A3193 NC_009800.1 3203458 3203715 D yqhH; outer membrane lipoprotein 3203458..3203715 Escherichia coli HS 5593425 YP_001459810.1 CDS EcHS_A3194 NC_009800.1 3203758 3205977 R identified by match to protein family HMM PF04055; match to protein family HMM PF08497; hypothetical protein complement(3203758..3205977) Escherichia coli HS 5593235 YP_001459811.1 CDS sufI NC_009800.1 3206088 3207500 R identified by similarity to SP:P26648; match to protein family HMM PF07731; match to protein family HMM PF07732; match to protein family HMM TIGR01409; repressor protein for FtsI complement(3206088..3207500) Escherichia coli HS 5593236 YP_001459812.1 CDS plsC NC_009800.1 3207575 3208312 R identified by similarity to SP:P26647; match to protein family HMM PF01553; match to protein family HMM TIGR00530; 1-acyl-sn-glycerol-3-phosphate acyltransferase complement(3207575..3208312) Escherichia coli HS 5593237 YP_001459813.1 CDS parC NC_009800.1 3208546 3210804 R decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A complement(3208546..3210804) Escherichia coli HS 5591642 YP_001459814.1 CDS EcHS_A3198 NC_009800.1 3210942 3212549 R YgiS; uncharacterized periplasmic protein that seems to be part of a binding-protein-dependent transport system; binding protein complement(3210942..3212549) Escherichia coli HS 5591643 YP_001459815.1 CDS EcHS_A3199 NC_009800.1 3212682 3213077 R ygiT; Cro/CI family transcriptional regulator complement(3212682..3213077) Escherichia coli HS 5591644 YP_001459816.1 CDS EcHS_A3200 NC_009800.1 3213079 3213375 R ygiU; identified by glimmer; hypothetical protein complement(3213079..3213375) Escherichia coli HS 5593035 YP_001459817.1 CDS EcHS_A3201 NC_009800.1 3213580 3214062 R identified by match to protein family HMM PF06445; transcription activator effector binding domain/DNA gyrase inhibitor domain-containing protein complement(3213580..3214062) Escherichia coli HS 5593036 YP_001459818.1 CDS EcHS_A3202 NC_009800.1 3214115 3214507 R ygiW; identified by match to protein family HMM PF04076; match to protein family HMM TIGR00156; hypothetical protein complement(3214115..3214507) Escherichia coli HS 5593037 YP_001459819.1 CDS qseB NC_009800.1 3214659 3215318 D response regulator in two-component regulatory system with QseC; regulates FlhCD which is the master regulator for flagella and motility genes; DNA-binding transcriptional regulator QseB 3214659..3215318 Escherichia coli HS 5593134 YP_001459820.1 CDS qseC NC_009800.1 3215315 3216664 D identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; sensor protein QseC 3215315..3216664 Escherichia coli HS 5593135 YP_001459821.1 CDS EcHS_A3205 NC_009800.1 3216710 3217042 R ygiZ; identified by similarity to SP:Q46867; hypothetical protein complement(3216710..3217042) Escherichia coli HS 5593136 YP_001459822.1 CDS mdaB NC_009800.1 3217361 3217942 D identified by similarity to SP:P0AEY5; match to protein family HMM PF02525; modulator of drug activity B 3217361..3217942 Escherichia coli HS 5592388 YP_001459823.1 CDS ygiN NC_009800.1 3217973 3218287 D ygiN; identified by similarity to PDB:1R6Y_A; match to protein family HMM PF03992; quinol monooxygenase YgiN 3217973..3218287 Escherichia coli HS 5592389 YP_001459824.1 CDS parE NC_009800.1 3218335 3220227 R decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B complement(3218335..3220227) Escherichia coli HS 5592390 YP_001459825.1 CDS yqiA NC_009800.1 3220256 3220837 R Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase complement(3220256..3220837) Escherichia coli HS 5592901 YP_001459826.1 CDS icc NC_009800.1 3220837 3221664 R identified by similarity to SP:P36650; match to protein family HMM PF00149; match to protein family HMM PF08413; cyclic 3',5'-adenosine monophosphate phosphodiesterase complement(3220837..3221664) Escherichia coli HS 5592902 YP_001459827.1 CDS EcHS_A3211 NC_009800.1 3221689 3222111 R identified by similarity to SP:P0ADV0; match to protein family HMM PF06853; hypothetical protein complement(3221689..3222111) Escherichia coli HS 5592903 YP_001459828.1 CDS nudF NC_009800.1 3222112 3222741 R ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose pyrophosphatase complement(3222112..3222741) Escherichia coli HS 5592898 YP_001459829.1 CDS tolC NC_009800.1 3222940 3224427 D trimeric outer membrane protein involved in efflux of hydrophobic/amphipathic molecules; functions with a number of efflux systems in the inner membrane to transport molecules out of the cell; outer membrane channel protein 3222940..3224427 Escherichia coli HS 5592899 YP_001459830.1 CDS EcHS_A3214 NC_009800.1 3224575 3225246 D ygiB; identified by similarity to GB:ABG71111.1; hypothetical protein 3224575..3225246 Escherichia coli HS 5592900 YP_001459831.1 CDS EcHS_A3215 NC_009800.1 3225252 3226412 D identified by match to protein family HMM PF03738; glutathionylspermidine synthase 3225252..3226412 Escherichia coli HS 5592378 YP_001459832.1 CDS EcHS_A3216 NC_009800.1 3226450 3227265 R seems to be involved in biofilm formation; in asymptomatic bacteriuria E. coli strains 83972 and VR50, the ygiD gene is upregulated during biofilm formation in urine; hypothetical protein complement(3226450..3227265) Escherichia coli HS 5592379 YP_001459833.1 CDS zupT NC_009800.1 3227381 3228154 D ygiE; identified by match to protein family HMM PF02535; zinc transporter ZupT 3227381..3228154 Escherichia coli HS 5592380 YP_001459834.1 CDS EcHS_A3218 NC_009800.1 3228212 3228406 R identified by similarity to GB:AAG58180.1; hypothetical protein complement(3228212..3228406) Escherichia coli HS 5593222 YP_001459835.1 CDS ribB NC_009800.1 3228644 3229297 R DHBP synthase; functions during riboflavin biosynthesis; 3,4-dihydroxy-2-butanone 4-phosphate synthase complement(3228644..3229297) Escherichia coli HS 5593223 YP_001459836.1 CDS EcHS_A3220 NC_009800.1 3229611 3229961 D yqiC; identified by match to protein family HMM PF04380; hypothetical protein 3229611..3229961 Escherichia coli HS 5593224 YP_001459837.1 CDS EcHS_A3221 NC_009800.1 3230245 3230796 D identified by match to protein family HMM PF00419; fimbrial protein 3230245..3230796 Escherichia coli HS 5592064 YP_001459838.1 CDS EcHS_A3222 NC_009800.1 3230856 3233357 D identified by match to protein family HMM PF00577; fimbrial usher protein 3230856..3233357 Escherichia coli HS 5592065 YP_001459839.1 CDS EcHS_A3223 NC_009800.1 3233379 3234128 D identified by match to protein family HMM PF00345; periplasmic pilus chaperone family protein 3233379..3234128 Escherichia coli HS 5592066 YP_001459840.1 CDS EcHS_A3224 NC_009800.1 3234130 3235194 D yqiI; identified by similarity to SP:P76656; hypothetical protein 3234130..3235194 Escherichia coli HS 5592956 YP_001459841.1 CDS glgS NC_009800.1 3235237 3235437 R Involved in glycogen synthesis. May be involved in glycogen priming; glycogen synthesis protein GlgS complement(3235237..3235437) Escherichia coli HS 5592957 YP_001459842.1 CDS EcHS_A3226 NC_009800.1 3235706 3236335 D identified by similarity to SP:P76657; match to protein family HMM PF07290; inner membrane protein 3235706..3236335 Escherichia coli HS 5592958 YP_001459843.1 CDS hldE NC_009800.1 3238709 3240142 R catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose; bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase complement(3238709..3240142) Escherichia coli HS 5592528 YP_001459844.1 CDS glnE NC_009800.1 3240190 3243030 R catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase complement(3240190..3243030) Escherichia coli HS 5592529 YP_001459845.1 CDS EcHS_A3231 NC_009800.1 3243053 3244354 R ygiF; identified by match to protein family HMM PF01928; match to protein family HMM PF05235; adenylate cyclase complement(3243053..3244354) Escherichia coli HS 5595178 YP_001459846.1 CDS EcHS_A3232 NC_009800.1 3244596 3245216 D ygiM; identified by similarity to GB:ABB63246.1; signal transduction protein 3244596..3245216 Escherichia coli HS 5595179 YP_001459847.1 CDS cca NC_009800.1 3245280 3246518 D catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases; multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase 3245280..3246518 Escherichia coli HS 5595180 YP_001459848.1 CDS EcHS_A3234 NC_009800.1 3246562 3246681 R identified by glimmer; hypothetical protein complement(3246562..3246681) Escherichia coli HS 5592616 YP_001459849.1 CDS uppP NC_009800.1 3246699 3247520 R BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; undecaprenyl pyrophosphate phosphatase complement(3246699..3247520) Escherichia coli HS 5592617 YP_001459850.1 CDS folB NC_009800.1 3247610 3247978 R catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin; bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase complement(3247610..3247978) Escherichia coli HS 5592618 YP_001459851.1 CDS EcHS_A3237 NC_009800.1 3248083 3248700 D involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; glycerol-3-phosphate acyltransferase PlsY 3248083..3248700 Escherichia coli HS 5593081 YP_001459852.1 CDS EcHS_A3238 NC_009800.1 3248713 3249162 R transcriptional regulator, truncation complement(3248713..3249162) Escherichia coli HS 5593082 YP_001459853.1 CDS EcHS_A3239 NC_009800.1 3249227 3249502 D identified by match to protein family HMM PF03811; IS1, transposase orfA 3249227..3249502 Escherichia coli HS 5593083 YP_001459854.1 CDS EcHS_A3240 NC_009800.1 3249421 3249924 D identified by match to protein family HMM PF03400; IS1, transposase orfB 3249421..3249924 Escherichia coli HS 5592334 YP_001459855.1 CDS ddtA NC_009800.1 3249926 3250819 D Involved in the tartrate degradation pathway; tartrate dehydratase subunit alpha 3249926..3250819 Escherichia coli HS 5592335 YP_001459856.1 CDS ttdB NC_009800.1 3250816 3251421 D Involved in the tartrate degradation pathway; L(+)-tartrate dehydratase subunit beta 3250816..3251421 Escherichia coli HS 5592336 YP_001459857.1 CDS EcHS_A3243 NC_009800.1 3251470 3252933 D ygjE; identified by match to protein family HMM PF00939; match to protein family HMM TIGR00785; anion transporter 3251470..3252933 Escherichia coli HS 5592216 YP_001459858.1 CDS gcp NC_009800.1 3252976 3253989 R in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease complement(3252976..3253989) Escherichia coli HS 5592217 YP_001459859.1 CDS rpsU NC_009800.1 3254226 3254441 D a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 3254226..3254441 Escherichia coli HS 5592218 YP_001459860.1 CDS dnaG NC_009800.1 3254552 3256297 D synthesizes RNA primers at the replication forks; DNA primase 3254552..3256297 Escherichia coli HS 5592245 YP_001459861.1 CDS rpoD NC_009800.1 3256492 3258333 D sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria; RNA polymerase sigma factor RpoD 3256492..3258333 Escherichia coli HS 5592247 YP_001459862.1 CDS mug NC_009800.1 3258412 3258918 R identified by similarity to SP:P0A9H1; match to protein family HMM PF03167; G/U mismatch-specific DNA glycosylase complement(3258412..3258918) Escherichia coli HS 5592697 YP_001459863.1 CDS EcHS_A3251 NC_009800.1 3259171 3259935 R identified by match to protein family HMM PF04954; match to protein family HMM PF08021; siderophore-interacting protein complement(3259171..3259935) Escherichia coli HS 5592699 YP_001459864.1 CDS EcHS_A3252 NC_009800.1 3260223 3260846 D yqjI; identified by match to protein family HMM PF03551; PadR family transcriptional regulator 3260223..3260846 Escherichia coli HS 5595079 YP_001459865.1 CDS aer NC_009800.1 3261000 3262520 R identified by match to protein family HMM PF00015; match to protein family HMM PF00672; match to protein family HMM PF08447; match to protein family HMM TIGR00229; aerotaxis receptor complement(3261000..3262520) Escherichia coli HS 5595080 YP_001459866.1 CDS EcHS_A3254 NC_009800.1 3262711 3262824 R identified by glimmer; hypothetical protein complement(3262711..3262824) Escherichia coli HS 5592666 YP_001459867.1 CDS ygjG NC_009800.1 3263028 3264317 D catalyzes the formation of 4-aminobutyraldehyde from putrescine and 2-oxoglutarate; putrescine--2-oxoglutarate aminotransferase 3263028..3264317 Escherichia coli HS 5592667 YP_001459868.1 CDS EcHS_A3256 NC_009800.1 3264359 3264691 R identified by match to protein family HMM PF01588; hypothetical protein complement(3264359..3264691) Escherichia coli HS 5592668 YP_001459869.1 CDS ebgR NC_009800.1 3264910 3265893 D identified by similarity to SP:P06846; match to protein family HMM PF00356; match to protein family HMM PF00532; DNA-binding transcriptional repressor EbgR 3264910..3265893 Escherichia coli HS 5592543 YP_001459870.1 CDS ebgA NC_009800.1 3266077 3269169 D in Escherichia coli this is the second beta-galactosidase system; cryptic beta-D-galactosidase subunit alpha 3266077..3269169 Escherichia coli HS 5592544 YP_001459871.1 CDS ebgC NC_009800.1 3269166 3269615 D in Escherichia coli this is the second beta-galactosidase system; cryptic beta-D-galactosidase subunit beta 3269166..3269615 Escherichia coli HS 5592545 YP_001459872.1 CDS EcHS_A3260 NC_009800.1 3269678 3271111 D identified by match to protein family HMM PF00324; amino acid permease 3269678..3271111 Escherichia coli HS 5592669 YP_001459873.1 CDS EcHS_A3261 NC_009800.1 3271245 3272315 D ygjJ; identified by similarity to GB:AAZ89711.1; hypothetical protein 3271245..3272315 Escherichia coli HS 5592670 YP_001459874.1 CDS EcHS_A3262 NC_009800.1 3272332 3274683 D identified by similarity to SP:P42592; glycosyl hydrolase 3272332..3274683 Escherichia coli HS 5592671 YP_001459875.1 CDS fadH NC_009800.1 3275009 3277027 D identified by similarity to SP:P42593; match to protein family HMM PF00724; match to protein family HMM PF07992; 2,4-dienoyl-CoA reductase 3275009..3277027 Escherichia coli HS 5591670 YP_001459876.1 CDS EcHS_A3264 NC_009800.1 3277072 3277488 R ygjM; identified by match to protein family HMM PF01381; helix-turn-helix DNA-binding domain-containing protein complement(3277072..3277488) Escherichia coli HS 5591671 YP_001459877.1 CDS EcHS_A3265 NC_009800.1 3277485 3277799 R ygjN; identified by similarity to GB:AAN53007.1; hypothetical protein complement(3277485..3277799) Escherichia coli HS 5591672 YP_001459878.1 CDS EcHS_A3266 NC_009800.1 3278084 3279220 R identified by match to protein family HMM PF05175; match to protein family HMM PF08242; methyltransferase complement(3278084..3279220) Escherichia coli HS 5592385 YP_001459879.1 CDS EcHS_A3267 NC_009800.1 3279305 3279808 D ygjP; identified by similarity to SP:P42597; match to protein family HMM PF01863; hypothetical protein 3279305..3279808 Escherichia coli HS 5592386 YP_001459880.1 CDS EcHS_A3268 NC_009800.1 3279885 3280568 D ygjQ; identified by similarity to SP:P33017; match to protein family HMM PF02698; SanA protein 3279885..3280568 Escherichia coli HS 5592387 YP_001459881.1 CDS EcHS_A3269 NC_009800.1 3280647 3281633 D ygjR; identified by match to protein family HMM PF01408; match to protein family HMM PF02894; oxidoreductase, NAD binding 3280647..3281633 Escherichia coli HS 5592619 YP_001459882.1 CDS alx NC_009800.1 3281916 3282881 D identified by similarity to SP:P42601; match to protein family HMM PF03741; protein Alx 3281916..3282881 Escherichia coli HS 5592621 YP_001459883.1 CDS EcHS_A3271 NC_009800.1 3282990 3283292 D identified by glimmer; hypothetical protein 3282990..3283292 Escherichia coli HS 5595076 YP_001459884.1 CDS sstT NC_009800.1 3283497 3284741 D involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 3283497..3284741 Escherichia coli HS 5595077 YP_001459885.1 CDS EcHS_A3273 NC_009800.1 3284746 3285297 R ygjV; identified by similarity to SP:P42603; inner membrane protein complement(3284746..3285297) Escherichia coli HS 5595078 YP_001459886.1 CDS uxaA NC_009800.1 3285380 3286867 R identified by similarity to SP:P42604; match to protein family HMM PF04295; match to protein family HMM PF08666; altronate dehydratase complement(3285380..3286867) Escherichia coli HS 5592292 YP_001459887.1 CDS uxaC NC_009800.1 3286882 3288294 R catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism; glucuronate isomerase complement(3286882..3288294) Escherichia coli HS 5592293 YP_001459888.1 CDS EcHS_A3276 NC_009800.1 3288777 3290075 D identified by match to protein family HMM PF07690; match to protein family HMM TIGR00893; hexuronate transporter 3288777..3290075 Escherichia coli HS 5592294 YP_001459889.1 CDS EcHS_A3277 NC_009800.1 3290163 3291251 R identified by match to protein family HMM PF07434; pilus biogenesis initiator complement(3290163..3291251) Escherichia coli HS 5592095 YP_001459890.1 CDS EcHS_A3278 NC_009800.1 3291248 3293950 R hypothetical protein complement(3291248..3293950) Escherichia coli HS 5592096 YP_001459891.1 CDS EcHS_A3279 NC_009800.1 3294023 3294523 R identified by match to protein family HMM PF04449; CS1 type fimbrial major subunit complement(3294023..3294523) Escherichia coli HS 5592097 YP_001459892.1 CDS EcHS_A3280 NC_009800.1 3294553 3295269 R fimbrial protein-like; hypothetical protein complement(3294553..3295269) Escherichia coli HS 5595021 YP_001459893.1 CDS exuR NC_009800.1 3295565 3296341 D regulates the exuT, uxaCA and uxuRAB operons which encode genes involved in hexuronate utilization.; DNA-binding transcriptional repressor ExuR 3295565..3296341 Escherichia coli HS 5595022 YP_001459894.1 CDS EcHS_A3282 NC_009800.1 3296686 3297348 D identified by similarity to SP:P0AA63; match to protein family HMM PF09335; inner membrane protein 3296686..3297348 Escherichia coli HS 5595023 YP_001459895.1 CDS EcHS_A3283 NC_009800.1 3297352 3297735 D yqjB; identified by similarity to GB:ABB63281.1; hypothetical protein 3297352..3297735 Escherichia coli HS 5592498 YP_001459896.1 CDS EcHS_A3284 NC_009800.1 3297720 3297815 R identified by glimmer; hypothetical protein complement(3297720..3297815) Escherichia coli HS 5592499 YP_001459897.1 CDS EcHS_A3285 NC_009800.1 3297882 3298250 D identified by similarity to SP:P42616; match to protein family HMM PF06476; hypothetical protein 3297882..3298250 Escherichia coli HS 5592500 YP_001459898.1 CDS EcHS_A3286 NC_009800.1 3298288 3298593 D yqjD; identified by similarity to GB:AAV78931.1; match to protein family HMM PF05957; hypothetical protein 3298288..3298593 Escherichia coli HS 5592057 YP_001459899.1 CDS EcHS_A3287 NC_009800.1 3298596 3299000 D yqjE; identified by similarity to GB:ABE08983.1; hypothetical protein 3298596..3299000 Escherichia coli HS 5592058 YP_001459900.1 CDS EcHS_A3288 NC_009800.1 3298990 3299289 D yqjK; identified by similarity to GB:AAZ89836.1; hypothetical protein 3298990..3299289 Escherichia coli HS 5592059 YP_001459901.1 CDS EcHS_A3289 NC_009800.1 3299475 3299867 D yqjF; identified by match to protein family HMM PF07681; inner membrane protein YqjF 3299475..3299867 Escherichia coli HS 5591820 YP_001459902.1 CDS EcHS_A3290 NC_009800.1 3299937 3300923 D hypothetical protein 3299937..3300923 Escherichia coli HS 5591821 YP_001459903.1 CDS EcHS_A3291 NC_009800.1 3300962 3301057 D identified by glimmer; hypothetical protein 3300962..3301057 Escherichia coli HS 5591822 YP_001459904.1 CDS EcHS_A3292 NC_009800.1 3301194 3301580 D identified by match to protein family HMM PF05656; inner membrane protein YhaH 3301194..3301580 Escherichia coli HS 5592510 YP_001459905.1 CDS EcHS_A3293 NC_009800.1 3301673 3301765 D identified by glimmer; hypothetical protein 3301673..3301765 Escherichia coli HS 5592511 YP_001459906.1 CDS EcHS_A3294 NC_009800.1 3301822 3302178 D identified by similarity to SP:P64592; match to protein family HMM PF05656; inner membrane protein 3301822..3302178 Escherichia coli HS 5592512 YP_001459907.1 CDS EcHS_A3295 NC_009800.1 3302229 3303125 R identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator complement(3302229..3303125) Escherichia coli HS 5595107 YP_001459908.1 CDS EcHS_A3296 NC_009800.1 3303230 3303931 D identified by match to protein family HMM PF02678; pirin 3303230..3303931 Escherichia coli HS 5595108 YP_001459909.1 CDS EcHS_A3297 NC_009800.1 3303954 3304118 D yhaL; identified by similarity to SP:P42625; hypothetical protein 3303954..3304118 Escherichia coli HS 5595109 YP_001459910.1 CDS EcHS_A3298 NC_009800.1 3304179 3305489 R yhaM; identified by match to protein family HMM PF06354; hypothetical protein complement(3304179..3305489) Escherichia coli HS 5592208 YP_001459911.1 CDS EcHS_A3299 NC_009800.1 3305517 3306848 R yhaO; identified by match to protein family HMM TIGR00814; serine transporter family protein complement(3305517..3306848) Escherichia coli HS 5592209 YP_001459912.1 CDS sdaA1 NC_009800.1 3307123 3308487 R identified by match to protein family HMM PF03313; match to protein family HMM PF03315; match to protein family HMM TIGR00720; L-serine ammonia-lyase complement(3307123..3308487) Escherichia coli HS 5592210 YP_001459913.1 CDS EcHS_A3301 NC_009800.1 3308559 3308948 R identified by match to protein family HMM PF01042; match to protein family HMM TIGR00004; hypothetical protein complement(3308559..3308948) Escherichia coli HS 5592236 YP_001459914.1 CDS pflB1 NC_009800.1 3308962 3311256 R identified by match to protein family HMM PF01228; match to protein family HMM PF02901; match to protein family HMM TIGR01255; formate acetyltransferase complement(3308962..3311256) Escherichia coli HS 5592237 YP_001459915.1 CDS tdcD NC_009800.1 3311290 3312498 R catalyzes the formation of propanoyl phosphate from propanoate and ATP; TdcD also has acetate kinase activities and functions in anaerobic threonine catabolism; propionate/acetate kinase complement(3311290..3312498) Escherichia coli HS 5592238 YP_001459916.1 CDS tdcC NC_009800.1 3312524 3313855 R involved in the import of threonine and serine in combination with the import of a proton; threonine/serine transporter TdcC complement(3312524..3313855) Escherichia coli HS 5592408 YP_001459917.1 CDS tdcB NC_009800.1 3313877 3314866 R catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic; threonine dehydratase complement(3313877..3314866) Escherichia coli HS 5592409 YP_001459918.1 CDS tdcA NC_009800.1 3314965 3315903 R regulates the tdcABCDEFG operon which is involved in amino acid degradation; DNA-binding transcriptional activator TdcA complement(3314965..3315903) Escherichia coli HS 5592410 YP_001459919.1 CDS tdcR NC_009800.1 3316218 3316436 D participates in controlling the expression of several structural genes for the enzyme threonine dehydratase; TdcR activates the tdcABCDEFG operon; DNA-binding transcriptional activator TdcR 3316218..3316436 Escherichia coli HS 5592355 YP_001459920.1 CDS EcHS_A3308 NC_009800.1 3316518 3316655 R identified by glimmer; hypothetical protein complement(3316518..3316655) Escherichia coli HS 5592356 YP_001459921.1 CDS EcHS_A3309 NC_009800.1 3316671 3317231 D yhaB; identified by glimmer; hypothetical protein 3316671..3317231 Escherichia coli HS 5592357 YP_001459922.1 CDS EcHS_A3311 NC_009800.1 3318521 3318673 R identified by glimmer; hypothetical protein complement(3318521..3318673) Escherichia coli HS 5591356 YP_001459923.1 CDS EcHS_A3312 NC_009800.1 3318674 3318883 R NULL; identified by glimmer; hypothetical protein complement(3318674..3318883) Escherichia coli HS 5591357 YP_001459924.1 CDS garK NC_009800.1 3319245 3320390 R yhaD; identified by similarity to SP:P23524; match to protein family HMM PF02595; match to protein family HMM TIGR00045; glycerate kinase I complement(3319245..3320390) Escherichia coli HS 5593871 YP_001459925.1 CDS garR NC_009800.1 3320487 3321371 R catalyzes the reduction of tartronate semialdehyde to glycerate; tartronate semialdehyde reductase complement(3320487..3321371) Escherichia coli HS 5592359 YP_001459926.1 CDS garL NC_009800.1 3321407 3322177 R cleaves 5-dehydro-4-deoxy-glucarate and 2-dehydro-3-deoxy-D-glucarate; alpha-dehydro-beta-deoxy-D-glucarate aldolase complement(3321407..3322177) Escherichia coli HS 5592360 YP_001459927.1 CDS garP NC_009800.1 3322193 3323527 R identified by match to protein family HMM PF07690; match to protein family HMM TIGR00893; galactarate permease GarP complement(3322193..3323527) Escherichia coli HS 5592101 YP_001459928.1 CDS EcHS_A3317 NC_009800.1 3323736 3323855 D identified by glimmer; hypothetical protein 3323736..3323855 Escherichia coli HS 5592102 YP_001459929.1 CDS garD NC_009800.1 3323902 3325473 D identified by similarity to SP:P39829; match to protein family HMM PF04295; match to protein family HMM PF08666; match to protein family HMM TIGR03248; galactarate dehydratase 3323902..3325473 Escherichia coli HS 5592103 YP_001459930.1 CDS sohA NC_009800.1 3325622 3325957 D SohA; PrlF; involved in protein secretion; when overproduced or mutated, it induces growth defect and increased export of a reporter protein; a PrlF mutation induces the activity of the Lon protease, and a Lon-deficient strain suppresses the phenotype conferred by the PrlF mutation; regulator PrlF 3325622..3325957 Escherichia coli HS 5592017 YP_001459931.1 CDS EcHS_A3320 NC_009800.1 3325957 3326421 D yhaV; identified by similarity to GB:AAZ89862.1; hypothetical protein 3325957..3326421 Escherichia coli HS 5592018 YP_001459932.1 CDS EcHS_A3321 NC_009800.1 3326476 3327285 R transcriptional repressor for the agaZVWA and agaSYBCDI operons; DNA-binding transcriptional regulator AgaR complement(3326476..3327285) Escherichia coli HS 5592019 YP_001459933.1 CDS EcHS_A3322 NC_009800.1 3327534 3328814 D identified by match to protein family HMM PF08013; match to protein family HMM TIGR02810; D-tagatose-bisphosphate aldolase, class II, non-catalytic subunit 3327534..3328814 Escherichia coli HS 5594473 YP_001459934.1 CDS agaV NC_009800.1 3328837 3329310 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N-acetylgalactosamine transport; N-acetylgalactosamine-specific PTS system transporter subunit IIB 3328837..3329310 Escherichia coli HS 5594474 YP_001459935.1 CDS agaW NC_009800.1 3329321 3330100 D identified by match to protein family HMM PF03609; PTS system, N-acetylgalactosamine-specific, IIC component 3329321..3330100 Escherichia coli HS 5594475 YP_001459936.1 CDS agaE NC_009800.1 3330090 3330968 D identified by similarity to GB:AAF81085.1; match to protein family HMM PF03613; PTS system N-acetylgalactosamine-specific, IID component 3330090..3330968 Escherichia coli HS 5594476 YP_001459937.1 CDS agaF NC_009800.1 3330986 3331420 D identified by similarity to GB:AAF81086.1; match to protein family HMM PF03610; PTS system, mannose/sorbose-specific, IIA component 3330986..3331420 Escherichia coli HS 5592781 YP_001459938.1 CDS nagA1 NC_009800.1 3331417 3332550 D identified by match to protein family HMM PF01979; match to protein family HMM TIGR00221; N-acetylglucosamine-6-phosphate deacetylase 3331417..3332550 Escherichia coli HS 5592782 YP_001459939.1 CDS EcHS_A3328 NC_009800.1 3332901 3334055 D identified by match to protein family HMM PF01380; match to protein family HMM TIGR02815; AgaS family sugar isomerase 3332901..3334055 Escherichia coli HS 5592783 YP_001459940.1 CDS kbaY NC_009800.1 3334068 3334928 D catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway; tagatose-bisphosphate aldolase 3334068..3334928 Escherichia coli HS 5592784 YP_001459941.1 CDS agaB NC_009800.1 3335095 3335571 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N-acetylgalactosamine transport; N-acetylgalactosamine-specific PTS system transporter subunit IIB 3335095..3335571 Escherichia coli HS 5593957 YP_001459942.1 CDS agaC NC_009800.1 3335610 3336413 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N-acetylgalactosamine transport; N-acetylgalactosamine-specific PTS system transporter subunit IIC 3335610..3336413 Escherichia coli HS 5593958 YP_001459943.1 CDS agaD NC_009800.1 3336403 3337194 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N-acetylgalactosamine transport; N-acetylgalactosamine-specific PTS system transporter subunit IID 3336403..3337194 Escherichia coli HS 5593959 YP_001459944.1 CDS agaI NC_009800.1 3337195 3337950 D identified by similarity to SP:P42912; match to protein family HMM PF01182; galactosamine-6-phosphate isomerase 3337195..3337950 Escherichia coli HS 5593960 YP_001459945.1 CDS EcHS_A3334 NC_009800.1 3338351 3338935 D identified by similarity to SP:P22595; match to protein family HMM PF00419; type 1 fimbrial protein 3338351..3338935 Escherichia coli HS 5594847 YP_001459946.1 CDS EcHS_A3335 NC_009800.1 3339015 3339710 D identified by match to protein family HMM PF00345; match to protein family HMM PF02753; pili assembly chaperone protein 3339015..3339710 Escherichia coli HS 5594848 YP_001459947.1 CDS EcHS_A3336 NC_009800.1 3339740 3342256 D identified by similarity to SP:P42915; match to protein family HMM PF00577; fimbrial usher family protein 3339740..3342256 Escherichia coli HS 5594849 YP_001459948.1 CDS EcHS_A3337 NC_009800.1 3342267 3343358 D identified by similarity to SP:P43319; fimbrial protein 3342267..3343358 Escherichia coli HS 5594850 YP_001459949.1 CDS EcHS_A3338 NC_009800.1 3343401 3344261 R yraL; identified by match to protein family HMM PF00590; match to protein family HMM TIGR00096; tetrapyrrole methylase complement(3343401..3344261) Escherichia coli HS 5594950 YP_001459950.1 CDS EcHS_A3339 NC_009800.1 3344326 3346362 D identified by match to protein family HMM PF04348; lipoprotein 3344326..3346362 Escherichia coli HS 5594951 YP_001459951.1 CDS EcHS_A3340 NC_009800.1 3346446 3346715 D yraN; identified by match to protein family HMM PF02021; match to protein family HMM TIGR00252; hypothetical protein 3346446..3346715 Escherichia coli HS 5594952 YP_001459952.1 CDS diaA NC_009800.1 3346735 3347325 D Required for the timely initiation of chromosomal replication via direct interactions with the dnaA initiator protein; DnaA initiator-associating protein DiaA 3346735..3347325 Escherichia coli HS 5594953 YP_001459953.1 CDS EcHS_A3342 NC_009800.1 3347335 3347910 D identified by match to protein family HMM PF04972; hypothetical protein 3347335..3347910 Escherichia coli HS 5591982 YP_001459954.1 CDS EcHS_A3343 NC_009800.1 3348024 3349064 R yraQ; identified by match to protein family HMM PF03773; permease complement(3348024..3349064) Escherichia coli HS 5591983 YP_001459955.1 CDS EcHS_A3344 NC_009800.1 3349137 3349772 R yraR; identified by match to protein family HMM PF01370; NAD dependent epimerase/dehydratase complement(3349137..3349772) Escherichia coli HS 5591984 YP_001459956.1 CDS EcHS_A3345 NC_009800.1 3349900 3350418 D yhbO; identified by match to protein family HMM PF01965; match to protein family HMM TIGR01382; PfpI family intracellular peptidase 3349900..3350418 Escherichia coli HS 5591985 YP_001459957.1 CDS EcHS_A3346 NC_009800.1 3350398 3350841 R yhbP; identified by similarity to GB:AAZ89875.1; hypothetical protein complement(3350398..3350841) Escherichia coli HS 5592160 YP_001459958.1 CDS EcHS_A3347 NC_009800.1 3350892 3351194 D identified by match to protein family HMM PF01541; GIY-YIG nuclease superfamily protein 3350892..3351194 Escherichia coli HS 5592161 YP_001459959.1 CDS EcHS_A3348 NC_009800.1 3351181 3351684 R yhbS; identified by match to protein family HMM PF00583; acetyltransferase complement(3351181..3351684) Escherichia coli HS 5592162 YP_001459960.1 CDS EcHS_A3349 NC_009800.1 3351678 3352202 R identified by match to protein family HMM PF02036; sterol-binding protein complement(3351678..3352202) Escherichia coli HS 5592163 YP_001459961.1 CDS EcHS_A3350 NC_009800.1 3352411 3353406 D identified by match to protein family HMM PF01136; U32 family peptidase 3352411..3353406 Escherichia coli HS 5592804 YP_001459962.1 CDS EcHS_A3351 NC_009800.1 3353415 3354293 D yhbV; identified by match to protein family HMM PF01136; U32 family peptidase 3353415..3354293 Escherichia coli HS 5592805 YP_001459963.1 CDS EcHS_A3352 NC_009800.1 3354374 3355381 D identified by match to protein family HMM PF00296; hypothetical protein 3354374..3355381 Escherichia coli HS 5592806 YP_001459964.1 CDS mtr NC_009800.1 3355499 3356743 R tryptophan transporter of high affinity; tryptophan permease complement(3355499..3356743) Escherichia coli HS 5592807 YP_001459965.1 CDS deaD NC_009800.1 3356897 3358852 R participates in the assembly of the large subunit of the ribosome; plays a key role in optimal cell growth at low temperature and is required for normal cell division; ATP-dependent RNA helicase DeaD complement(3356897..3358852) Escherichia coli HS 5591113 YP_001459966.1 CDS nlpI NC_009800.1 3358966 3359850 R lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing; lipoprotein NlpI complement(3358966..3359850) Escherichia coli HS 5591114 YP_001459967.1 CDS pnp NC_009800.1 3359959 3362094 R identified by similarity to SP:P05055; match to protein family HMM PF00013; match to protein family HMM PF00575; match to protein family HMM PF01138; match to protein family HMM PF03725; match to protein family HMM PF03726; polynucleotide phosphorylase complement(3359959..3362094) Escherichia coli HS 5591115 YP_001459968.1 CDS rpsO NC_009800.1 3362341 3362610 R primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 complement(3362341..3362610) Escherichia coli HS 5592089 YP_001459969.1 CDS truB NC_009800.1 3362759 3363703 R catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B complement(3362759..3363703) Escherichia coli HS 5592091 YP_001459970.1 CDS rbfA NC_009800.1 3363703 3364104 R associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A complement(3363703..3364104) Escherichia coli HS 5592855 YP_001459971.1 CDS infB NC_009800.1 3364268 3366940 R Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 complement(3364268..3366940) Escherichia coli HS 5592856 YP_001459972.1 CDS nusA NC_009800.1 3366965 3368452 R modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA complement(3366965..3368452) Escherichia coli HS 5592857 YP_001459973.1 CDS EcHS_A3362 NC_009800.1 3368480 3368932 R in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein complement(3368480..3368932) Escherichia coli HS 5593109 YP_001459974.1 CDS argG NC_009800.1 3369563 3370906 D catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis; argininosuccinate synthase 3369563..3370906 Escherichia coli HS 5593111 YP_001459975.1 CDS yhbX NC_009800.1 3370914 3372539 R identified by match to protein family HMM PF00884; hypothetical protein complement(3370914..3372539) Escherichia coli HS 5593356 YP_001459976.1 CDS secG NC_009800.1 3373099 3373431 R identified by match to protein family HMM PF03840; match to protein family HMM TIGR00810; preprotein translocase subunit SecG complement(3373099..3373431) Escherichia coli HS 5593358 YP_001459977.1 CDS glmM NC_009800.1 3373659 3374996 R catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase complement(3373659..3374996) Escherichia coli HS 5593400 YP_001459978.1 CDS folP NC_009800.1 3374989 3375837 R catalyzes the formation of dihydropteroate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate; dihydropteroate synthase complement(3374989..3375837) Escherichia coli HS 5593401 YP_001459979.1 CDS hflB NC_009800.1 3375927 3377870 R inner membrane metalloprotease; may be involved in degradation of aberrant cytoplasmic and membrane proteins; ATP-dependent metalloprotease complement(3375927..3377870) Escherichia coli HS 5593402 YP_001459980.1 CDS rrmJ NC_009800.1 3377961 3378590 R Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit; 23S rRNA methyltransferase complement(3377961..3378590) Escherichia coli HS 5593403 YP_001459981.1 CDS EcHS_A3372 NC_009800.1 3378716 3379009 D RNA binding protein found associated to pre-50S subunit of the ribosome; role in ribosome assembly; necessary for optimal growth but not cell viability; RNA-binding protein YhbY 3378716..3379009 Escherichia coli HS 5593930 YP_001459982.1 CDS greA NC_009800.1 3379165 3379641 R necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA complement(3379165..3379641) Escherichia coli HS 5593931 YP_001459983.1 CDS dacB NC_009800.1 3379889 3381322 D penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase/endopeptidase 3379889..3381322 Escherichia coli HS 5593932 YP_001459984.1 CDS EcHS_A3375 NC_009800.1 3381371 3381511 D identified by glimmer; hypothetical protein 3381371..3381511 Escherichia coli HS 5593933 YP_001459985.1 CDS obgE NC_009800.1 3381508 3382680 R essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE complement(3381508..3382680) Escherichia coli HS 5594114 YP_001459986.1 CDS EcHS_A3377 NC_009800.1 3382696 3383661 R yhbE; identified by match to protein family HMM PF00892; transporter complement(3382696..3383661) Escherichia coli HS 5594115 YP_001459987.1 CDS rpmA NC_009800.1 3383788 3384045 R involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 complement(3383788..3384045) Escherichia coli HS 5594116 YP_001459988.1 CDS rplU NC_009800.1 3384066 3384377 R identified by match to protein family HMM PF00829; match to protein family HMM TIGR00061; 50S ribosomal protein L21 complement(3384066..3384377) Escherichia coli HS 5594117 YP_001459989.1 CDS ispB NC_009800.1 3384636 3385607 D identified by similarity to SP:P0AD57; match to protein family HMM PF00348; octaprenyl diphosphate synthase 3384636..3385607 Escherichia coli HS 5594234 YP_001459990.1 CDS sfsB NC_009800.1 3385836 3386114 D activator of maltose metabolism genes; DNA-binding transcriptional regulator Nlp 3385836..3386114 Escherichia coli HS 5594235 YP_001459991.1 CDS murA NC_009800.1 3386162 3387421 R adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase complement(3386162..3387421) Escherichia coli HS 5594236 YP_001459992.1 CDS EcHS_A3383 NC_009800.1 3387542 3387883 D identified by similarity to GB:AAN82389.1; hypothetical protein 3387542..3387883 Escherichia coli HS 5594237 YP_001459993.1 CDS yrbB NC_009800.1 3387890 3388183 R hypothetical protein complement(3387890..3388183) Escherichia coli HS 5591089 YP_001459994.1 CDS EcHS_A3384 NC_009800.1 3388171 3388806 D identified by similarity to GB:AAN82391.1; hypothetical protein 3388171..3388806 Escherichia coli HS 5591090 YP_001459995.1 CDS EcHS_A3386 NC_009800.1 3388837 3389388 R yrbD; identified by match to protein family HMM PF02470; Mce family protein complement(3388837..3389388) Escherichia coli HS 5591091 YP_001459996.1 CDS EcHS_A3387 NC_009800.1 3389393 3390175 R yrbE; identified by match to protein family HMM PF02405; match to protein family HMM TIGR00056; toluene ABC transporter permease complement(3389393..3390175) Escherichia coli HS 5591092 YP_001459997.1 CDS EcHS_A3388 NC_009800.1 3390183 3390992 R ATP-binding subunit of a ABC toluene efflux transporter; ABC transporter ATP-binding protein YrbF complement(3390183..3390992) Escherichia coli HS 5593416 YP_001459998.1 CDS EcHS_A3389 NC_009800.1 3391202 3392179 D YrbG; inner membrane protein involved in cell envelope integrity; sodium ion/calcium ion exchanger; in E. coli it is non essential for cell viability; member of the YRBG family of cation/Ca2+ exchangers; calcium/sodium:proton antiporter 3391202..3392179 Escherichia coli HS 5593417 YP_001459999.1 CDS kdsD NC_009800.1 3392193 3393179 D identified by similarity to SP:P45395; match to protein family HMM PF00571; match to protein family HMM PF01380; match to protein family HMM TIGR00393; D-arabinose 5-phosphate isomerase 3392193..3393179 Escherichia coli HS 5593418 YP_001460000.1 CDS kdsC NC_009800.1 3393200 3393766 D forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase 3393200..3393766 Escherichia coli HS 5593419 YP_001460001.1 CDS EcHS_A3392 NC_009800.1 3393763 3394338 D yrbK; identified by match to protein family HMM PF06835; hypothetical protein 3393763..3394338 Escherichia coli HS 5593102 YP_001460002.1 CDS lptA NC_009800.1 3394307 3394864 D LptA; periplasmic binding protein part of a ABC superfamily of uptake transporters; interacts with LptB protein, the ATP binding component of the uptake system; lipopolysaccharide transport periplasmic protein LptA 3394307..3394864 Escherichia coli HS 5593103 YP_001460003.1 CDS lptB NC_009800.1 3394871 3395596 D identified by similarity to SP:P0A9V1; match to protein family HMM PF00005; ABC transporter ATP-binding protein YhbG 3394871..3395596 Escherichia coli HS 5593104 YP_001460004.1 CDS rpoN NC_009800.1 3395644 3397077 D sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen; RNA polymerase factor sigma-54 3395644..3397077 Escherichia coli HS 5593105 YP_001460005.1 CDS yfiA NC_009800.1 3397100 3397387 D YhbH; resting ribosome-binding protein involved in ribosome stabilization and preservation in stationary phase; binds specifically 100S ribosomes (an inactive ribosome product of a 70S ribosome dimerization); seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing; sigma(54) modulation protein 3397100..3397387 Escherichia coli HS 5592930 YP_001460006.1 CDS ptsN NC_009800.1 3397505 3397996 D identified by similarity to SP:P69829; match to protein family HMM PF00359; match to protein family HMM TIGR01419; PTS IIA-like nitrogen-regulatory protein PtsN 3397505..3397996 Escherichia coli HS 5592931 YP_001460007.1 CDS EcHS_A3398 NC_009800.1 3398042 3398896 D yhbJ; identified by match to protein family HMM PF03668; hypothetical protein 3398042..3398896 Escherichia coli HS 5592932 YP_001460008.1 CDS ptsO NC_009800.1 3398893 3399165 D identified by match to protein family HMM PF00381; match to protein family HMM TIGR01003; phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) 3398893..3399165 Escherichia coli HS 5592933 YP_001460009.1 CDS EcHS_A3400 NC_009800.1 3399379 3400011 D yrbL; identified by similarity to SP:P64611; hypothetical protein 3399379..3400011 Escherichia coli HS 5595427 YP_001460010.1 CDS mtgA NC_009800.1 3400008 3400736 R glycosyltransferase; polymerizes glycan strands in the peptidoglycan; monofunctional biosynthetic peptidoglycan transglycosylase complement(3400008..3400736) Escherichia coli HS 5595428 YP_001460011.1 CDS elbB NC_009800.1 3400733 3401386 R identified by similarity to SP:P0ABU5; match to protein family HMM PF01965; isoprenoid biosynthesis protein with amidotransferase-like domain complement(3400733..3401386) Escherichia coli HS 5595429 YP_001460012.1 CDS arcB NC_009800.1 3401616 3403952 R sensor-regulator protein which regulates the expression of many genes in response to respiratory growth conditions including anaerobic repression of the arc modulon; hybrid sensory histidine kinase in two-component regulatory system with ArcA; aerobic respiration control sensor protein ArcB complement(3401616..3403952) Escherichia coli HS 5593772 YP_001460013.1 CDS EcHS_A3404 NC_009800.1 3404048 3404977 R identified by match to protein family HMM PF04055; match to protein family HMM TIGR01212; radical SAM family protein complement(3404048..3404977) Escherichia coli HS 5593773 YP_001460014.1 CDS gltB NC_009800.1 3405652 3410112 D catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate; glutamate synthase subunit alpha 3405652..3410112 Escherichia coli HS 5593774 YP_001460015.1 CDS gltD NC_009800.1 3410125 3411543 D glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; glutamate synthase subunit beta 3410125..3411543 Escherichia coli HS 5593362 YP_001460016.1 CDS EcHS_A3407 NC_009800.1 3411727 3412206 D identified by similarity to GB:ABB63386.1; match to protein family HMM PF06250; hypothetical protein 3411727..3412206 Escherichia coli HS 5593363 YP_001460017.1 CDS EcHS_A3408 NC_009800.1 3412187 3412528 D identified by glimmer; hypothetical protein 3412187..3412528 Escherichia coli HS 5593364 YP_001460018.1 CDS EcHS_A3409 NC_009800.1 3412604 3413068 R yhcH; identified by similarity to SP:P0AF97; match to protein family HMM PF04074; match to protein family HMM TIGR00022; hypothetical protein complement(3412604..3413068) Escherichia coli HS 5593365 YP_001460019.1 CDS EcHS_A3410 NC_009800.1 3413065 3413940 R catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein; N-acetylmannosamine kinase complement(3413065..3413940) Escherichia coli HS 5593483 YP_001460020.1 CDS EcHS_A3411 NC_009800.1 3413937 3414626 R Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase complement(3413937..3414626) Escherichia coli HS 5593484 YP_001460021.1 CDS nanT1 NC_009800.1 3414674 3416164 R identified by match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM TIGR00891; sialic acid transporter complement(3414674..3416164) Escherichia coli HS 5593485 YP_001460022.1 CDS nanA NC_009800.1 3416273 3417166 R catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid; N-acetylneuraminate lyase complement(3416273..3417166) Escherichia coli HS 5593486 YP_001460023.1 CDS nanR NC_009800.1 3417288 3418070 R Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization; transcriptional regulator NanR complement(3417288..3418070) Escherichia coli HS 5591232 YP_001460024.1 CDS sspB NC_009800.1 3419867 3420364 R identified by match to protein family HMM PF04386; ClpXP protease specificity-enhancing factor complement(3419867..3420364) Escherichia coli HS 5591234 YP_001460025.1 CDS sspA NC_009800.1 3420370 3421008 R transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation; stringent starvation protein A complement(3420370..3421008) Escherichia coli HS 5591235 YP_001460026.1 CDS rpsI NC_009800.1 3421403 3421795 R forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 complement(3421403..3421795) Escherichia coli HS 5591436 YP_001460027.1 CDS rplM NC_009800.1 3421811 3422239 R in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 complement(3421811..3422239) Escherichia coli HS 5591437 YP_001460028.1 CDS EcHS_A3421 NC_009800.1 3422458 3423585 R identified by match to protein family HMM PF03969; AFG1 family ATPase complement(3422458..3423585) Escherichia coli HS 5591438 YP_001460029.1 CDS EcHS_A3422 NC_009800.1 3423779 3424177 D yhcB; identified by match to protein family HMM PF06295; cytochrome d ubiquinol oxidase subunit III 3423779..3424177 Escherichia coli HS 5591439 YP_001460030.1 CDS degQ NC_009800.1 3424331 3425698 D identified by similarity to SP:P39099; match to protein family HMM PF00089; match to protein family HMM PF00595; match to protein family HMM TIGR02037; serine endoprotease 3424331..3425698 Escherichia coli HS 5592346 YP_001460031.1 CDS degS NC_009800.1 3425788 3426855 D identified by match to protein family HMM PF00089; match to protein family HMM PF00595; match to protein family HMM TIGR02038; serine endoprotease 3425788..3426855 Escherichia coli HS 5592347 YP_001460032.1 CDS mdh NC_009800.1 3426918 3427856 R oxidizes malate to oxaloacetate; malate dehydrogenase complement(3426918..3427856) Escherichia coli HS 5592348 YP_001460033.1 CDS argR NC_009800.1 3428291 3428761 D regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor ArgR 3428291..3428761 Escherichia coli HS 5592349 YP_001460034.1 CDS ycfR NC_009800.1 3429126 3429389 D yhcN; identified by similarity to SP:P0AB40; match to protein family HMM PF07338; protein YcfR 3429126..3429389 Escherichia coli HS 5593727 YP_001460035.1 CDS EcHS_A3428 NC_009800.1 3429445 3429717 R yhcO; identified by similarity to SP:P64616; hypothetical protein complement(3429445..3429717) Escherichia coli HS 5593728 YP_001460036.1 CDS aaeB NC_009800.1 3429809 3431776 R with AaeA forms an efflux pump whose substrates are p-hydroxybenzoic acid 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeB complement(3429809..3431776) Escherichia coli HS 5593729 YP_001460037.1 CDS aaeA NC_009800.1 3431782 3432714 R with AaeB forms an efflux pump whose substrates are p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeA complement(3431782..3432714) Escherichia coli HS 5593730 YP_001460038.2 CDS aaeX NC_009800.1 3432722 3432925 R membrane protein AaeX; the gene is a member of the aaeXAB operon; hypothetical protein complement(3432722..3432925) Escherichia coli HS 5595239 YP_001460039.1 CDS aaeR NC_009800.1 3433108 3434037 D identified by match to protein family HMM PF00126; match to protein family HMM PF03466; DNA-binding transcriptional regulator 3433108..3434037 Escherichia coli HS 5595240 YP_001460040.1 CDS tldD NC_009800.1 3434171 3435616 R responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase; degrades the E. coli plasmid F-encoded CcdA; protease TldD complement(3434171..3435616) Escherichia coli HS 5595241 YP_001460041.1 CDS EcHS_A3435 NC_009800.1 3436046 3439846 R yhdP; identified by match to protein family HMM TIGR02099; hypothetical protein complement(3436046..3439846) Escherichia coli HS 5593846 YP_001460042.1 CDS cafA NC_009800.1 3439914 3441383 R involved in the processing of the 5'end of 16S rRNA; ribonuclease G complement(3439914..3441383) Escherichia coli HS 5593847 YP_001460043.1 CDS maf1 NC_009800.1 3441373 3441966 R Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein complement(3441373..3441966) Escherichia coli HS 5593848 YP_001460044.1 CDS lytS NC_009800.1 3441975 3442463 R part of cell wall structural complex MreBCD; transmembrane component; rod shape-determining protein MreD complement(3441975..3442463) Escherichia coli HS 5593849 YP_001460045.1 CDS mreC NC_009800.1 3442463 3443566 R in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC complement(3442463..3443566) Escherichia coli HS 5594580 YP_001460046.1 CDS mreB NC_009800.1 3443632 3444675 R functions in MreBCD complex in some organisms; rod shape-determining protein MreB complement(3443632..3444675) Escherichia coli HS 5594581 YP_001460047.1 CDS EcHS_A3441 NC_009800.1 3444783 3444971 D identified by similarity to GB:AAN82447.1; hypothetical protein 3444783..3444971 Escherichia coli HS 5594582 YP_001460048.1 CDS EcHS_A3442 NC_009800.1 3444980 3446920 R regulates the degradation of the small RNAs CsrB and CsrC; may function to targate RNase E to specific RNA molecules; regulatory protein CsrD complement(3444980..3446920) Escherichia coli HS 5594583 YP_001460049.1 CDS EcHS_A3443 NC_009800.1 3447072 3448046 D identified by similarity to PDB:1O8C_A; match to protein family HMM PF00107; match to protein family HMM PF08240; match to protein family HMM TIGR02823; quinone oxidoreductase 3447072..3448046 Escherichia coli HS 5594121 YP_001460050.1 CDS EcHS_A3444 NC_009800.1 3448083 3448913 D identified by similarity to GB:ABB63419.1; hypothetical protein 3448083..3448913 Escherichia coli HS 5594122 YP_001460051.1 CDS EcHS_A3445 NC_009800.1 3448931 3449029 D identified by glimmer; hypothetical protein 3448931..3449029 Escherichia coli HS 5594123 YP_001460052.1 CDS EcHS_A3446 NC_009800.1 3449138 3449206 D NULL; identified by glimmer; hypothetical protein 3449138..3449206 Escherichia coli HS 5594124 YP_001460053.1 CDS accB NC_009800.1 3449779 3450249 D composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 3449779..3450249 Escherichia coli HS 5593472 YP_001460054.1 CDS accC NC_009800.1 3450260 3451609 D an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 3450260..3451609 Escherichia coli HS 5593473 YP_001460055.1 CDS EcHS_A3449 NC_009800.1 3451718 3451960 D yhdT; identified by match to protein family HMM PF06196; hypothetical protein 3451718..3451960 Escherichia coli HS 5593474 YP_001460056.1 CDS panF NC_009800.1 3451950 3453401 D mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase; sodium/panthothenate symporter 3451950..3453401 Escherichia coli HS 5593475 YP_001460057.1 CDS prmA NC_009800.1 3453413 3454294 D methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; ribosomal protein L11 methyltransferase 3453413..3454294 Escherichia coli HS 5592226 YP_001460058.1 CDS EcHS_A3452 NC_009800.1 3454359 3454451 D identified by glimmer; hypothetical protein 3454359..3454451 Escherichia coli HS 5592227 YP_001460059.1 CDS dusB NC_009800.1 3454623 3455588 D identified by similarity to SP:P0ABT5; match to protein family HMM PF01207; match to protein family HMM TIGR00737; tRNA-dihydrouridine synthase B 3454623..3455588 Escherichia coli HS 5592228 YP_001460060.1 CDS fis NC_009800.1 3455614 3455910 D Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription; DNA-binding protein Fis 3455614..3455910 Escherichia coli HS 5592229 YP_001460061.1 CDS EcHS_A3455 NC_009800.1 3455996 3456880 D identified by match to protein family HMM PF01555; methyltransferase 3455996..3456880 Escherichia coli HS 5591443 YP_001460062.1 CDS EcHS_A3456 NC_009800.1 3456937 3457143 D yhdU; identified by similarity to GB:AAN82469.1; hypothetical protein 3456937..3457143 Escherichia coli HS 5591444 YP_001460063.1 CDS EcHS_A3457 NC_009800.1 3457146 3457808 R identified by similarity to SP:P0ACT2; match to protein family HMM PF00440; match to protein family HMM PF08361; DNA-binding transcriptional regulator EnvR complement(3457146..3457808) Escherichia coli HS 5591445 YP_001460064.1 CDS acrE NC_009800.1 3458207 3459364 D identified by similarity to SP:P24180; match to protein family HMM PF00529; match to protein family HMM TIGR01730; acriflavine resistance protein E 3458207..3459364 Escherichia coli HS 5591446 YP_001460065.1 CDS acrF NC_009800.1 3459376 3462480 D identified by similarity to SP:P24181; match to protein family HMM PF00873; match to protein family HMM TIGR00915; acriflavine resistance protein F 3459376..3462480 Escherichia coli HS 5594803 YP_001460066.1 CDS EcHS_A3460 NC_009800.1 3462733 3462954 D yhdV; lipoprotein 3462733..3462954 Escherichia coli HS 5594804 YP_001460067.1 CDS EcHS_A3461 NC_009800.1 3463180 3463356 D identified by glimmer; hypothetical protein 3463180..3463356 Escherichia coli HS 5594805 YP_001460068.1 CDS EcHS_A3462 NC_009800.1 3463385 3464410 D yhdW; amino acid ABC transporter substrate-binding protein 3463385..3464410 Escherichia coli HS 5594806 YP_001460069.1 CDS EcHS_A3463 NC_009800.1 3464478 3465659 D identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; His/Glu/Gln/Arg/opine ABC transporter permease 3464478..3465659 Escherichia coli HS 5591313 YP_001460070.1 CDS EcHS_A3466 NC_009800.1 3466779 3467537 D yhdZ; identified by match to protein family HMM PF00005; amino acid ABC transporter ATP-binding protein 3466779..3467537 Escherichia coli HS 5591315 YP_001460071.1 CDS EcHS_A3473 NC_009800.1 3473363 3474133 D identified by similarity to GB:AAZ89983.1; hypothetical protein 3473363..3474133 Escherichia coli HS 5592056 YP_001460072.1 CDS EcHS_A3474 NC_009800.1 3474109 3474366 R yrdB; identified by similarity to SP:P45795; match to protein family HMM PF07369; hypothetical protein complement(3474109..3474366) Escherichia coli HS 5593864 YP_001460073.1 CDS aroE NC_009800.1 3474363 3475181 R AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase complement(3474363..3475181) Escherichia coli HS 5593865 YP_001460074.1 CDS EcHS_A3476 NC_009800.1 3475186 3475803 R RimN; YrdC; required for maturation of 16s RNA; binds preferentially double stranded RNA; ribosome maturation factor complement(3475186..3475803) Escherichia coli HS 5593866 YP_001460075.1 CDS EcHS_A3477 NC_009800.1 3475763 3476305 R identified by match to protein family HMM PF01396; topoisomerase DNA-binding C4 zinc finger domain-containing protein complement(3475763..3476305) Escherichia coli HS 5593867 YP_001460076.1 CDS smg NC_009800.1 3476334 3476807 R smg; identified by match to protein family HMM PF04361; hypothetical protein complement(3476334..3476807) Escherichia coli HS 5595056 YP_001460077.1 CDS dprA NC_009800.1 3476779 3477903 R smf; identified by match to protein family HMM PF02481; match to protein family HMM TIGR00732; DNA protecting protein DprA complement(3476779..3477903) Escherichia coli HS 5595057 YP_001460078.1 CDS def NC_009800.1 3478033 3478542 D cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 3478033..3478542 Escherichia coli HS 5595058 YP_001460079.1 CDS fmt NC_009800.1 3478557 3479504 D modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 3478557..3479504 Escherichia coli HS 5595059 YP_001460080.1 CDS rsmB NC_009800.1 3479550 3480839 D catalyzes the methylation of cytosine at position 967 (m5C967) of 16S rRNA; SAM-dependent methyltransferase; 16S rRNA methyltransferase GidB 3479550..3480839 Escherichia coli HS 5591816 YP_001460081.1 CDS trkA NC_009800.1 3480861 3482237 D involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane component 3480861..3482237 Escherichia coli HS 5591817 YP_001460082.1 CDS mscL NC_009800.1 3482367 3482777 D forms homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel 3482367..3482777 Escherichia coli HS 5591818 YP_001460083.1 CDS EcHS_A3485 NC_009800.1 3482774 3482992 R identified by match to protein family HMM PF03889; hypothetical protein complement(3482774..3482992) Escherichia coli HS 5591819 YP_001460084.1 CDS zntR NC_009800.1 3483048 3483473 R mediates expression of the zinc export protein ZntA in response to high levels of zinc; member of MerR family of transcriptional regulators; zinc-responsive transcriptional regulator complement(3483048..3483473) Escherichia coli HS 5595130 YP_001460085.1 CDS EcHS_A3487 NC_009800.1 3483484 3483852 R yhdN; identified by similarity to SP:P36677; hypothetical protein complement(3483484..3483852) Escherichia coli HS 5595131 YP_001460086.1 CDS rplQ NC_009800.1 3483959 3484342 R is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 complement(3483959..3484342) Escherichia coli HS 5595132 YP_001460087.1 CDS rpoA NC_009800.1 3484383 3485372 R catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha complement(3484383..3485372) Escherichia coli HS 5595133 YP_001460088.1 CDS rpsD NC_009800.1 3485398 3486018 R primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 complement(3485398..3486018) Escherichia coli HS 5592188 YP_001460089.1 CDS rpsK NC_009800.1 3486052 3486441 R located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 complement(3486052..3486441) Escherichia coli HS 5592189 YP_001460090.1 CDS rpsM NC_009800.1 3486458 3486814 R located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 complement(3486458..3486814) Escherichia coli HS 5592190 YP_001460091.1 CDS rpmJ NC_009800.1 3486961 3487077 R smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 complement(3486961..3487077) Escherichia coli HS 5592191 YP_001460092.1 CDS secY NC_009800.1 3487109 3488440 R forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY complement(3487109..3488440) Escherichia coli HS 5595124 YP_001460093.1 CDS rplO NC_009800.1 3488448 3488882 R late assembly protein; 50S ribosomal protein L15 complement(3488448..3488882) Escherichia coli HS 5595125 YP_001460094.1 CDS rpmD NC_009800.1 3488886 3489065 R L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 complement(3488886..3489065) Escherichia coli HS 5595126 YP_001460095.1 CDS rpsE NC_009800.1 3489069 3489572 R located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 complement(3489069..3489572) Escherichia coli HS 5592427 YP_001460096.1 CDS rplR NC_009800.1 3489587 3489940 R binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 complement(3489587..3489940) Escherichia coli HS 5592428 YP_001460097.1 CDS rplF NC_009800.1 3489950 3490483 R ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 complement(3489950..3490483) Escherichia coli HS 5592429 YP_001460098.1 CDS rpsH NC_009800.1 3490496 3490888 R binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 complement(3490496..3490888) Escherichia coli HS 5592430 YP_001460099.1 CDS rpsN NC_009800.1 3490922 3491227 R located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 complement(3490922..3491227) Escherichia coli HS 5592606 YP_001460100.1 CDS rplE NC_009800.1 3491242 3491781 R part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 complement(3491242..3491781) Escherichia coli HS 5592607 YP_001460101.1 CDS rplX NC_009800.1 3491796 3492110 R assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 complement(3491796..3492110) Escherichia coli HS 5592608 YP_001460102.1 CDS rplN NC_009800.1 3492121 3492492 R binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 complement(3492121..3492492) Escherichia coli HS 5592609 YP_001460103.1 CDS rpsQ NC_009800.1 3492657 3492911 R primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 complement(3492657..3492911) Escherichia coli HS 5593057 YP_001460104.1 CDS rpmC NC_009800.1 3492911 3493102 R one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 complement(3492911..3493102) Escherichia coli HS 5593058 YP_001460105.1 CDS rplP NC_009800.1 3493102 3493512 R located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 complement(3493102..3493512) Escherichia coli HS 5593059 YP_001460106.1 CDS rpsC NC_009800.1 3493525 3494226 R forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 complement(3493525..3494226) Escherichia coli HS 5593060 YP_001460107.1 CDS rplV NC_009800.1 3494244 3494576 R binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 complement(3494244..3494576) Escherichia coli HS 5592732 YP_001460108.1 CDS rpsS NC_009800.1 3494591 3494869 R protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 complement(3494591..3494869) Escherichia coli HS 5592733 YP_001460109.1 CDS rplB NC_009800.1 3494886 3495707 R one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 complement(3494886..3495707) Escherichia coli HS 5592734 YP_001460110.1 CDS rplW NC_009800.1 3495725 3496027 R binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 complement(3495725..3496027) Escherichia coli HS 5592735 YP_001460111.1 CDS rplD NC_009800.1 3496024 3496629 R L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 complement(3496024..3496629) Escherichia coli HS 5592739 YP_001460112.1 CDS rplC NC_009800.1 3496640 3497269 R binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 complement(3496640..3497269) Escherichia coli HS 5592740 YP_001460113.1 CDS rpsJ NC_009800.1 3497302 3497613 R NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 complement(3497302..3497613) Escherichia coli HS 5592741 YP_001460114.1 CDS pioO NC_009800.1 3497851 3498270 R calcium-binding protein that may be required for the initiation of chromosome replication; chromosome replication protein PioO complement(3497851..3498270) Escherichia coli HS 5592742 YP_001460115.1 CDS EcHS_A3517 NC_009800.1 3498272 3499741 R identified by match to protein family HMM PF01471; general secretory pathway protein A complement(3498272..3499741) Escherichia coli HS 5593284 YP_001460116.1 CDS gspC2 NC_009800.1 3499921 3500736 D identified by match to protein family HMM TIGR01713; general secretion pathway protein C 3499921..3500736 Escherichia coli HS 5593285 YP_001460117.1 CDS gspD1 NC_009800.1 3500708 3502672 D identified by match to protein family HMM PF00263; match to protein family HMM PF03958; match to protein family HMM TIGR02517; general secretion pathway protein D 3500708..3502672 Escherichia coli HS 5593286 YP_001460118.1 CDS gspE1 NC_009800.1 3502682 3504163 D identified by similarity to SP:P45759; match to protein family HMM PF00437; match to protein family HMM TIGR02533; general secretory pathway protein E 3502682..3504163 Escherichia coli HS 5593287 YP_001460119.1 CDS gspF1 NC_009800.1 3504160 3505356 D identified by match to protein family HMM PF00482; match to protein family HMM TIGR02120; general secretion pathway protein F 3504160..3505356 Escherichia coli HS 5593610 YP_001460120.1 CDS gspG1 NC_009800.1 3505366 3505803 D identified by match to protein family HMM PF07963; match to protein family HMM PF08334; match to protein family HMM TIGR01710; match to protein family HMM TIGR02532; general secretion pathway protein G 3505366..3505803 Escherichia coli HS 5593611 YP_001460121.1 CDS gspH1 NC_009800.1 3505811 3506320 D identified by match to protein family HMM PF07963; match to protein family HMM TIGR01708; match to protein family HMM TIGR02532; general secretion pathway protein H 3505811..3506320 Escherichia coli HS 5593612 YP_001460122.1 CDS gspI1 NC_009800.1 3506317 3506694 D identified by match to protein family HMM PF02501; match to protein family HMM TIGR01707; match to protein family HMM TIGR02532; general secretion pathway protein I 3506317..3506694 Escherichia coli HS 5593613 YP_001460123.1 CDS gspJ1 NC_009800.1 3506687 3507274 D identified by match to protein family HMM PF07963; match to protein family HMM TIGR01711; match to protein family HMM TIGR02532; general secretion pathway protein J 3506687..3507274 Escherichia coli HS 5593456 YP_001460124.1 CDS gspK1 NC_009800.1 3507267 3508250 D identified by match to protein family HMM PF03934; general secretion pathway protein K 3507267..3508250 Escherichia coli HS 5593457 YP_001460125.1 CDS gspL1 NC_009800.1 3508265 3509428 D identified by match to protein family HMM PF05134; match to protein family HMM TIGR01709; general secretion pathway protein L 3508265..3509428 Escherichia coli HS 5593458 YP_001460126.1 CDS EcHS_A3528 NC_009800.1 3509401 3509886 D identified by match to protein family HMM PF04612; general secretion pathway protein M 3509401..3509886 Escherichia coli HS 5593459 YP_001460127.1 CDS gspO NC_009800.1 3509886 3510563 D identified by match to protein family HMM PF01478; type 4 prepilin peptidase 3509886..3510563 Escherichia coli HS 5593496 YP_001460128.1 CDS bfr NC_009800.1 3510592 3511068 R iron storage protein; bacterioferritin complement(3510592..3511068) Escherichia coli HS 5593497 YP_001460129.1 CDS bfd NC_009800.1 3511140 3511334 R identified by similarity to SP:P0AE56; match to protein family HMM PF04324; bacterioferritin-associated ferredoxin complement(3511140..3511334) Escherichia coli HS 5593498 YP_001460130.1 CDS EcHS_A3532 NC_009800.1 3511384 3511500 R identified by glimmer; hypothetical protein complement(3511384..3511500) Escherichia coli HS 5593499 YP_001460131.1 CDS chiA NC_009800.1 3511503 3514196 R identified by match to protein family HMM PF02839; bifunctional chitinase/lysozyme complement(3511503..3514196) Escherichia coli HS 5593701 YP_001460132.1 CDS EcHS_A3534 NC_009800.1 3514281 3514439 R identified by glimmer; hypothetical protein complement(3514281..3514439) Escherichia coli HS 5593702 YP_001460133.1 CDS tuf2 NC_009800.1 3514488 3515672 R EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu complement(3514488..3515672) Escherichia coli HS 5593703 YP_001460134.1 CDS fusA NC_009800.1 3515743 3517857 R EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G complement(3515743..3517857) Escherichia coli HS 5593704 YP_001460135.1 CDS rpsG NC_009800.1 3517954 3518424 R binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 complement(3517954..3518424) Escherichia coli HS 5593836 YP_001460136.1 CDS rpsL NC_009800.1 3518521 3518895 R interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 complement(3518521..3518895) Escherichia coli HS 5593837 YP_001460137.1 CDS dsrH NC_009800.1 3519021 3519308 R in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusB complement(3519021..3519308) Escherichia coli HS 5593838 YP_001460138.1 CDS tusC NC_009800.1 3519316 3519675 R in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur relay protein TusC complement(3519316..3519675) Escherichia coli HS 5593839 YP_001460139.1 CDS tusD NC_009800.1 3519675 3520061 R in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusD complement(3519675..3520061) Escherichia coli HS 5594036 YP_001460140.1 CDS EcHS_A3542 NC_009800.1 3520061 3520783 R yheO; identified by similarity to GB:AAV79134.1; match to protein family HMM PF08348; hypothetical protein complement(3520061..3520783) Escherichia coli HS 5594037 YP_001460141.1 CDS fkpA NC_009800.1 3520950 3521762 R rotamase; FKBP-type peptidylprolyl isomerase complement(3520950..3521762) Escherichia coli HS 5594038 YP_001460142.1 CDS EcHS_A3544 NC_009800.1 3521983 3522201 D identified by match to protein family HMM PF04102; hypothetical protein 3521983..3522201 Escherichia coli HS 5594039 YP_001460143.1 CDS slyD NC_009800.1 3522250 3522840 R rotamase; FKBP-type peptidylprolyl isomerase complement(3522250..3522840) Escherichia coli HS 5594006 YP_001460144.1 CDS EcHS_A3546 NC_009800.1 3522935 3523135 R identified by similarity to SP:P0ADW8; match to protein family HMM TIGR02443; hypothetical protein complement(3522935..3523135) Escherichia coli HS 5594007 YP_001460145.1 CDS kefB NC_009800.1 3523145 3524950 R involved in potassium efflux; glutathione-regulated potassium-efflux system protein KefB complement(3523145..3524950) Escherichia coli HS 5594008 YP_001460146.1 CDS kefG NC_009800.1 3524950 3525504 R required for KefB activity; glutathione-regulated potassium-efflux system ancillary protein KefG complement(3524950..3525504) Escherichia coli HS 5594009 YP_001460147.1 CDS EcHS_A3549 NC_009800.1 3525632 3527545 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 3525632..3527545 Escherichia coli HS 5594020 YP_001460148.1 CDS EcHS_A3550 NC_009800.1 3527545 3528567 D yheT; identified by match to protein family HMM PF00561; hydrolase 3527545..3528567 Escherichia coli HS 5594021 YP_001460149.1 CDS EcHS_A3551 NC_009800.1 3528561 3528779 D yheU; identified by match to protein family HMM PF06794; hypothetical protein 3528561..3528779 Escherichia coli HS 5594022 YP_001460150.1 CDS EcHS_A3552 NC_009800.1 3528833 3529702 D identified by match to protein family HMM PF00485; phosphoribulokinase/uridine kinase 3528833..3529702 Escherichia coli HS 5594023 YP_001460151.1 CDS EcHS_A3553 NC_009800.1 3529757 3530161 R yhfA; identified by match to protein family HMM PF02566; hypothetical protein complement(3529757..3530161) Escherichia coli HS 5594110 YP_001460152.1 CDS crp NC_009800.1 3530463 3531095 D complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons; cAMP-regulatory protein 3530463..3531095 Escherichia coli HS 5594111 YP_001460153.1 CDS EcHS_A3555 NC_009800.1 3531146 3533236 D yhfK; identified by match to protein family HMM PF05976; match to protein family HMM TIGR01667; hypothetical protein 3531146..3533236 Escherichia coli HS 5594112 YP_001460154.1 CDS argD NC_009800.1 3533303 3534523 R DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate; bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase complement(3533303..3534523) Escherichia coli HS 5594113 YP_001460155.1 CDS pabA NC_009800.1 3534609 3535172 R aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; para-aminobenzoate synthase component II complement(3534609..3535172) Escherichia coli HS 5594463 YP_001460156.1 CDS fic NC_009800.1 3535204 3535806 R identified by similarity to SP:P20605; match to protein family HMM PF02661; cell filamentation protein Fic complement(3535204..3535806) Escherichia coli HS 5594464 YP_001460157.1 CDS ppiA NC_009800.1 3536068 3536640 R identified by similarity to SP:P20752; match to protein family HMM PF00160; peptidyl-prolyl cis-trans isomerase A (rotamase A) complement(3536068..3536640) Escherichia coli HS 5594465 YP_001460158.1 CDS tsgA NC_009800.1 3536911 3538092 D identified by match to protein family HMM PF07690; hypothetical protein 3536911..3538092 Escherichia coli HS 5594466 YP_001460159.1 CDS nirB NC_009800.1 3538355 3540898 D identified by similarity to SP:P08201; match to protein family HMM PF00070; match to protein family HMM PF01077; match to protein family HMM PF03460; match to protein family HMM PF04324; match to protein family HMM PF07992; match to protein family HMM TIGR02374; nitrite reductase [NAD(P)H], large subunit 3538355..3540898 Escherichia coli HS 5595272 YP_001460160.1 CDS nirD NC_009800.1 3540895 3541221 D involved in reducing nitrite to ammonium to detoxify nitrite accumulation in anaerobic nitrate-respiring cells and regenerate NAD+; bounds to NirB, the cytoplasmic subunit, whose expression is induced at high nitrate concentrations; nitrite reductase small subunit 3540895..3541221 Escherichia coli HS 5595273 YP_001460161.1 CDS nirC NC_009800.1 3541348 3542154 D member of the FNT family of formate and nitrite transporters; nitrite transporter NirC 3541348..3542154 Escherichia coli HS 5595274 YP_001460162.1 CDS cysG NC_009800.1 3542173 3543546 D multifunction enzyme consisting of uroporphyrin-III C-methyltransferase, precorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase; catalyzes the methylation of uroporphyrinogen III to form precorrin-2, then catalyzes formation of sirohydrochlorin from precorrin-2 and finally catalyzed the formation of siroheme from sirohydrochlorin; siroheme synthase 3542173..3543546 Escherichia coli HS 5595275 YP_001460163.1 CDS EcHS_A3565 NC_009800.1 3543793 3543960 D yhfL; lipoprotein 3543793..3543960 Escherichia coli HS 5594164 YP_001460164.1 CDS frlA NC_009800.1 3544204 3545592 D inner membrane protein possibly involved in fructoselysine transport; member of the flr operon; fructoselysine transporter 3544204..3545592 Escherichia coli HS 5594165 YP_001460165.1 CDS frlB NC_009800.1 3545592 3546635 D catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine; fructoselysine-6-P-deglycase 3545592..3546635 Escherichia coli HS 5594166 YP_001460166.1 CDS EcHS_A3568 NC_009800.1 3546685 3547515 D YhfOP; YhfP; YhfO; FrlC; catalyzes the interconversion of fructoselysine and psicoselysine; fructoselysine 3-epimerase 3546685..3547515 Escherichia coli HS 5594167 YP_001460167.1 CDS EcHS_A3569 NC_009800.1 3547512 3548297 D identified by match to protein family HMM PF00294; fructoselysine 6-kinase 3547512..3548297 Escherichia coli HS 5594548 YP_001460168.1 CDS frlR NC_009800.1 3548397 3549128 D may act as a transcriptional regulator of a fructoselysine-induced operon containing the yhfM, yhfN, yhfO, yhfP, yhfQ, and yhfR genes; DNA-binding transcriptional regulator FrlR 3548397..3549128 Escherichia coli HS 5594549 YP_001460169.1 CDS EcHS_A3571 NC_009800.1 3549280 3550365 R yhfS; identified by similarity to GB:ABB67851.1; hypothetical protein complement(3549280..3550365) Escherichia coli HS 5594550 YP_001460170.1 CDS EcHS_A3572 NC_009800.1 3550377 3551681 R identified by similarity to SP:P45546; hypothetical protein complement(3550377..3551681) Escherichia coli HS 5594551 YP_001460171.1 CDS EcHS_A3573 NC_009800.1 3551693 3552046 R yhfU; hypothetical protein complement(3551693..3552046) Escherichia coli HS 5594629 YP_001460172.1 CDS EcHS_A3574 NC_009800.1 3552057 3552935 R phosphotriesterase homology protein; PhP; YhfV; member of a family of proteins related to phosphotriesterase (PTE); hydrolase complement(3552057..3552935) Escherichia coli HS 5594630 YP_001460173.1 CDS EcHS_A3575 NC_009800.1 3552932 3554158 R identified by match to protein family HMM PF01676; match to protein family HMM PF08342; mutase complement(3552932..3554158) Escherichia coli HS 5594631 YP_001460174.1 CDS EcHS_A3576 NC_009800.1 3554158 3555321 R yhfX; identified by match to protein family HMM PF01168; alanine racemase complement(3554158..3555321) Escherichia coli HS 5594632 YP_001460175.1 CDS EcHS_A3577 NC_009800.1 3555405 3555767 R yhfY; hypothetical protein complement(3555405..3555767) Escherichia coli HS 5595356 YP_001460176.1 CDS EcHS_A3578 NC_009800.1 3555784 3556689 R yhfZ; identified by similarity to OMNI:NTL01SF3196; hypothetical protein complement(3555784..3556689) Escherichia coli HS 5595357 YP_001460177.1 CDS EcHS_A3579 NC_009800.1 3556715 3556960 R identified by similarity to GB:AAZ87440.1; hypothetical protein complement(3556715..3556960) Escherichia coli HS 5595358 YP_001460178.1 CDS trpS NC_009800.1 3556979 3557983 R catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase complement(3556979..3557983) Escherichia coli HS 5595359 YP_001460179.1 CDS gph NC_009800.1 3557976 3558734 R catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate; phosphoglycolate phosphatase complement(3557976..3558734) Escherichia coli HS 5595481 YP_001460180.1 CDS rpe NC_009800.1 3558727 3559404 R catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase complement(3558727..3559404) Escherichia coli HS 5595482 YP_001460181.1 CDS dam NC_009800.1 3559422 3560258 R identified by match to protein family HMM PF02086; match to protein family HMM TIGR00571; DNA adenine methylase complement(3559422..3560258) Escherichia coli HS 5595483 YP_001460182.1 CDS damX NC_009800.1 3560365 3561663 R identified by similarity to SP:P11557; match to protein family HMM PF05036; hypothetical protein complement(3560365..3561663) Escherichia coli HS 5595484 YP_001460183.1 CDS aroB NC_009800.1 3561755 3562843 R catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase complement(3561755..3562843) Escherichia coli HS 5595507 YP_001460184.1 CDS aroK NC_009800.1 3562900 3563421 R type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase I complement(3562900..3563421) Escherichia coli HS 5595508 YP_001460185.1 CDS hofQ NC_009800.1 3563822 3565060 R outer membrane porin probably involved in uptake of extracellular double-stranded DNA; similar to outer membrane competence protein ComE from Haemophilus influenzae and outer membrane protein PilQ involved in type IV pilus production from Pseudomonas aeruginosa; outer membrane porin HofQ complement(3563822..3565060) Escherichia coli HS 5595509 YP_001460186.1 CDS EcHS_A3588 NC_009800.1 3565366 3565806 R yrfB; hypothetical protein complement(3565366..3565806) Escherichia coli HS 5595510 YP_001460187.1 CDS EcHS_A3589 NC_009800.1 3565790 3566329 R yrfC; identified by match to protein family HMM PF05137; PilN family protein complement(3565790..3566329) Escherichia coli HS 5594876 YP_001460188.1 CDS hofM NC_009800.1 3566329 3567108 R yrfD; identified by similarity to SP:P45753; HofM protein complement(3566329..3567108) Escherichia coli HS 5594877 YP_001460189.1 CDS mrcA NC_009800.1 3567228 3569780 D bifunctional murein transglycosylase/murein transpeptidase; penicillin-binding protein 1A; involved in the synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation; penicillin-insensitive transglycosylase catalyzes the formation of linear glycan strands and the penicillin-sensitive transpeptidase catalyzes the cross-linking of the peptide subunits; peptidoglycan synthetase 3567228..3569780 Escherichia coli HS 5594878 YP_001460190.1 CDS nudE NC_009800.1 3569948 3570508 R ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose diphosphatase NudE complement(3569948..3570508) Escherichia coli HS 5594879 YP_001460191.1 CDS EcHS_A3593 NC_009800.1 3570712 3570831 D identified by glimmer; hypothetical protein 3570712..3570831 Escherichia coli HS 5591900 YP_001460192.1 CDS EcHS_A3594 NC_009800.1 3570828 3572963 D identified by similarity to SP:P45800; match to protein family HMM PF07095; hypothetical protein 3570828..3572963 Escherichia coli HS 5591901 YP_001460193.1 CDS EcHS_A3595 NC_009800.1 3573028 3573696 D identified by match to protein family HMM PF00702; match to protein family HMM TIGR01509; HAD family hydrolase 3573028..3573696 Escherichia coli HS 5591902 YP_001460194.1 CDS hslR NC_009800.1 3573707 3574108 D identified by similarity to SP:P45802; match to protein family HMM PF01479; ribosome-associated heat shock protein Hsp15 3573707..3574108 Escherichia coli HS 5591903 YP_001460195.1 CDS hslO NC_009800.1 3574127 3575011 D becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 3574127..3575011 Escherichia coli HS 5594837 YP_001460196.1 CDS EcHS_A3598 NC_009800.1 3575074 3576798 R identified by similarity to SP:P45804; hypothetical protein complement(3575074..3576798) Escherichia coli HS 5594838 YP_001460197.1 CDS EcHS_A3599 NC_009800.1 3576874 3577005 R identified by similarity to GB:AAN44882.1; hypothetical protein complement(3576874..3577005) Escherichia coli HS 5594839 YP_001460198.1 CDS pckA NC_009800.1 3577177 3578799 D PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase 3577177..3578799 Escherichia coli HS 5594840 YP_001460199.1 CDS envZ NC_009800.1 3578875 3580227 R membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR; osmolarity sensor protein complement(3578875..3580227) Escherichia coli HS 5591710 YP_001460200.1 CDS ompR NC_009800.1 3580224 3580943 R part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation; osmolarity response regulator complement(3580224..3580943) Escherichia coli HS 5591711 YP_001460201.1 CDS greB NC_009800.1 3581171 3581647 D necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreB 3581171..3581647 Escherichia coli HS 5591712 YP_001460202.1 CDS yhgF NC_009800.1 3581744 3584065 D identified by similarity to SP:P46837; match to protein family HMM PF00575; protein yhgF 3581744..3584065 Escherichia coli HS 5591713 YP_001460203.1 CDS feoA NC_009800.1 3584503 3584730 D identified by match to protein family HMM PF04023; ferrous iron transport protein A 3584503..3584730 Escherichia coli HS 5593664 YP_001460204.1 CDS feoB NC_009800.1 3584747 3587068 D cytoplasmic membrane ferrous uptake system permease; mutations disrupt the ability of Escherichia coli to take up ferrous iron; GTP-binding protein which requires GTP for efficient iron(II) uptake; ferrous iron transport protein B 3584747..3587068 Escherichia coli HS 5593665 YP_001460205.1 CDS EcHS_A3607 NC_009800.1 3587068 3587304 D yhgG; identified by match to protein family HMM PF09012; hypothetical protein 3587068..3587304 Escherichia coli HS 5593666 YP_001460206.1 CDS EcHS_A3608 NC_009800.1 3587507 3588385 D yhgA; identified by match to protein family HMM PF04754; match to protein family HMM TIGR01784; hypothetical protein 3587507..3588385 Escherichia coli HS 5593667 YP_001460207.1 CDS EcHS_A3609 NC_009800.1 3588414 3589184 R Shows carboxylesterase activity with a preference for short chain fatty acid esters; involved in pimeloyl-CoA synthesis; carboxylesterase BioH complement(3588414..3589184) Escherichia coli HS 5594704 YP_001460208.1 CDS gntX NC_009800.1 3589222 3589905 D involved in high-affinity gluconate transport; gluconate periplasmic binding protein 3589222..3589905 Escherichia coli HS 5594705 YP_001460209.1 CDS gntY NC_009800.1 3589964 3590539 D cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source; DNA uptake protein 3589964..3590539 Escherichia coli HS 5594706 YP_001460210.1 CDS EcHS_A3612 NC_009800.1 3590792 3590884 D identified by glimmer; hypothetical protein 3590792..3590884 Escherichia coli HS 5594707 YP_001460211.1 CDS gntT NC_009800.1 3590900 3592216 D identified by match to protein family HMM PF02447; match to protein family HMM PF03600; match to protein family HMM TIGR00791; high-affinity gluconate transporter 3590900..3592216 Escherichia coli HS 5594934 YP_001460212.1 CDS malQ NC_009800.1 3592261 3594345 R amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase complement(3592261..3594345) Escherichia coli HS 5594935 YP_001460213.1 CDS malP NC_009800.1 3594355 3596748 R identified by similarity to SP:P00490; match to protein family HMM PF00343; match to protein family HMM TIGR02093; maltodextrin phosphorylase complement(3594355..3596748) Escherichia coli HS 5594936 YP_001460214.1 CDS malT NC_009800.1 3597360 3600065 D Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides; transcriptional regulator MalT 3597360..3600065 Escherichia coli HS 5594937 YP_001460215.1 CDS rtcA NC_009800.1 3600108 3601124 R catalyzes the conversion of terminal3'-phosphate of RNA to the 2',3'-cyclicphosphodiester; RNA 3'-terminal-phosphate cyclase complement(3600108..3601124) Escherichia coli HS 5594399 YP_001460216.1 CDS rtcB NC_009800.1 3601128 3602354 R identified by similarity to SP:P46850; match to protein family HMM PF01139; RtcB protein complement(3601128..3602354) Escherichia coli HS 5594400 YP_001460217.1 CDS rtcR NC_009800.1 3602543 3604135 D identified by similarity to SP:P38035; match to protein family HMM PF00158; match to protein family HMM PF06956; match to protein family HMM PF07728; sigma-54 dependent transcriptional regulator RtcR 3602543..3604135 Escherichia coli HS 5594401 YP_001460218.1 CDS glpR NC_009800.1 3604117 3604875 R represses the glpD, glpFK, glpTQ, and glpACB operons involved in glycerol-3-phosphate metabolism; DNA-binding transcriptional repressor GlpR complement(3604117..3604875) Escherichia coli HS 5594402 YP_001460219.1 CDS EcHS_A3621 NC_009800.1 3604892 3605722 R protease responsible for the cleavage between Ser and Asp residues of proteins in regions of high local hydrophilicity; intramembrane serine protease GlpG complement(3604892..3605722) Escherichia coli HS 5594689 YP_001460220.1 CDS glpE NC_009800.1 3605767 3606093 R belongs to rhodanese family; thiosulfate thiotransferase; in Escherichia coli this enzyme catalyzes the formation of thiocyanate from thiosulfate and cyanide with low efficiency; contains an active site cysteine; thiosulfate sulfurtransferase complement(3605767..3606093) Escherichia coli HS 5594690 YP_001460221.1 CDS glpD NC_009800.1 3606283 3607788 D in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane; glycerol-3-phosphate dehydrogenase 3606283..3607788 Escherichia coli HS 5594691 YP_001460222.1 CDS EcHS_A3624 NC_009800.1 3608004 3608603 R NULL; hypothetical protein complement(3608004..3608603) Escherichia coli HS 5594692 YP_001460223.1 CDS EcHS_A3625 NC_009800.1 3608606 3609598 R identified by similarity to GB:AAL22389.1; hypothetical protein complement(3608606..3609598) Escherichia coli HS 5594209 YP_001460224.1 CDS EcHS_A3626 NC_009800.1 3609624 3610739 R hypothetical protein complement(3609624..3610739) Escherichia coli HS 5594210 YP_001460225.1 CDS glgP NC_009800.1 3611171 3613618 R identified by match to protein family HMM PF00343; match to protein family HMM TIGR02093; glycogen phosphorylase complement(3611171..3613618) Escherichia coli HS 5594212 YP_001460226.1 CDS glgA NC_009800.1 3613637 3615070 R catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase complement(3613637..3615070) Escherichia coli HS 5594222 YP_001460227.1 CDS glgC NC_009800.1 3615070 3616365 R catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase complement(3615070..3616365) Escherichia coli HS 5594223 YP_001460228.1 CDS glgX NC_009800.1 3616383 3618356 R catalyzes the hydrolysis of the alpha-1,6-glucosidic linkages in partially depolymerized glycogen; glycogen debranching enzyme complement(3616383..3618356) Escherichia coli HS 5594224 YP_001460229.1 CDS glgB NC_009800.1 3618353 3620539 R catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching enzyme complement(3618353..3620539) Escherichia coli HS 5594225 YP_001460230.1 CDS asd NC_009800.1 3620812 3621915 R catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase complement(3620812..3621915) Escherichia coli HS 5594793 YP_001460231.1 CDS EcHS_A3634 NC_009800.1 3622107 3622700 D YhgN; Ec0197; hydrolyzes nucleoside triphosphates with an O6 atom-containing purine base to nucleoside monophosphate and pyrophosphate; seems to play a role in the elimination of aberrant purine-derived nucleotides containing the 6-keto group; shows preference for deoxyinosine triphosphate and xanthosine triphosphate over standard nucleoside triphosphates (dATP, dCTP, dGTP, and dTTP); dITP- and XTP- hydrolase 3622107..3622700 Escherichia coli HS 5594794 YP_001460232.1 CDS gntU NC_009800.1 3622757 3624097 R identified by similarity to SP:P0AC96; match to protein family HMM PF02447; match to protein family HMM PF03600; match to protein family HMM TIGR00791; low affinity gluconate transporter complement(3622757..3624097) Escherichia coli HS 5594795 YP_001460233.1 CDS gntK NC_009800.1 3624101 3624628 R thermoresistant; catalyzes the formation of 6-phospho-D-gluconate from gluconate; gluconate kinase 1 complement(3624101..3624628) Escherichia coli HS 5594796 YP_001460234.1 CDS gntR NC_009800.1 3624767 3625762 R identified by similarity to SP:P0ACP5; match to protein family HMM PF00356; match to protein family HMM PF00532; GntR family transcriptional regulator complement(3624767..3625762) Escherichia coli HS 5594325 YP_001460235.1 CDS EcHS_A3638 NC_009800.1 3625986 3626681 R identified by match to protein family HMM PF02678; match to protein family HMM PF07883; pirin complement(3625986..3626681) Escherichia coli HS 5594326 YP_001460236.1 CDS EcHS_A3639 NC_009800.1 3626804 3627841 R identified by match to protein family HMM PF01408; match to protein family HMM PF02894; dehydrogenase complement(3626804..3627841) Escherichia coli HS 5594327 YP_001460237.1 CDS EcHS_A3640 NC_009800.1 3628173 3628661 D YhhY; regulated by the fur regulator; unknown function; acetyltransferase YhhY 3628173..3628661 Escherichia coli HS 5594231 YP_001460238.1 CDS EcHS_A3641 NC_009800.1 3628898 3630076 D identified by match to protein family HMM PF01844; match to protein family HMM PF05638; match to protein family HMM TIGR03344; HNH endonuclease domain-containing protein 3628898..3630076 Escherichia coli HS 5594232 YP_001460239.1 CDS EcHS_A3642 NC_009800.1 3630073 3630567 D hypothetical protein 3630073..3630567 Escherichia coli HS 5594233 YP_001460240.1 CDS EcHS_A3643 NC_009800.1 3631017 3631301 D identified by glimmer; hypothetical protein 3631017..3631301 Escherichia coli HS 5594570 YP_001460241.1 CDS ggt NC_009800.1 3631339 3633081 R periplasmic enzyme; post-translationally processed into two subunits which are required for wild-type enzyme activity; cleaves the gammaglutamyl linkages of compounds such as glutathione and transfer the gammaglutamyl group to other amino acids and peptides; gamma-glutamyltranspeptidase complement(3631339..3633081) Escherichia coli HS 5594571 YP_001460242.1 CDS EcHS_A3645 NC_009800.1 3633201 3633641 D yhhA; hypothetical protein 3633201..3633641 Escherichia coli HS 5594572 YP_001460243.1 CDS ugpQ NC_009800.1 3633628 3634371 R hydrolyzes diesters during transport at the inner face of the cytoplasmic membrane to glycerol-3-phosphate and alcohol; induced when cells are starved for inorganic phosphate; cytoplasmic glycerophosphodiester phosphodiesterase complement(3633628..3634371) Escherichia coli HS 5594573 YP_001460244.1 CDS ugpC NC_009800.1 3634368 3635438 R part of the UgpABCE glycerol-3-phosphate uptake system; glycerol-3-phosphate transporter ATP-binding subunit complement(3634368..3635438) Escherichia coli HS 5594087 YP_001460245.1 CDS EcHS_A3648 NC_009800.1 3635440 3636285 R with UgpABC is involved in uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter membrane protein complement(3635440..3636285) Escherichia coli HS 5594088 YP_001460246.1 CDS ugpA NC_009800.1 3636282 3637169 R with UgpEC is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter permease complement(3636282..3637169) Escherichia coli HS 5594089 YP_001460247.1 CDS ugpB NC_009800.1 3637267 3638583 R with UgpACE is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter periplasmic binding protein complement(3637267..3638583) Escherichia coli HS 5594090 YP_001460248.1 CDS livF NC_009800.1 3638980 3639681 R with LivGHMJ and LivGHMK is part of the high-affinity branched-chain amino acid transport system; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding subunit complement(3638980..3639681) Escherichia coli HS 5593433 YP_001460249.1 CDS livG NC_009800.1 3639695 3640462 R Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding subunit complement(3639695..3640462) Escherichia coli HS 5593434 YP_001460250.1 CDS livM NC_009800.1 3640459 3641736 R Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter permease subunit complement(3640459..3641736) Escherichia coli HS 5593435 YP_001460251.1 CDS livH NC_009800.1 3641733 3642659 R LivHMGF is the membrane component of the LIV-I/LS branched-chain amino acid transporter; branched-chain amino acid transporter permease subunit LivH complement(3641733..3642659) Escherichia coli HS 5594556 YP_001460252.1 CDS livK NC_009800.1 3642707 3643816 R identified by match to protein family HMM PF01094; high-affinity branched-chain amino acid ABC transporter periplasmic leucine-specific-binding protein LivK complement(3642707..3643816) Escherichia coli HS 5594557 YP_001460253.1 CDS EcHS_A3657 NC_009800.1 3643968 3644105 R identified by glimmer; hypothetical protein complement(3643968..3644105) Escherichia coli HS 5594558 YP_001460254.1 CDS EcHS_A3658 NC_009800.1 3644240 3644623 D identified by match to protein family HMM PF00583; acetyltransferase 3644240..3644623 Escherichia coli HS 5594559 YP_001460255.1 CDS livJ NC_009800.1 3644822 3645925 R identified by match to protein family HMM PF01094; high-affinity branched-chain amino acid ABC transporter periplasmic Leu/Ile/Val-binding protein LivJ complement(3644822..3645925) Escherichia coli HS 5594497 YP_001460256.1 CDS rpoH NC_009800.1 3646196 3647050 R binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 complement(3646196..3647050) Escherichia coli HS 5594498 YP_001460257.1 CDS ftsX NC_009800.1 3647295 3648353 R ABC transporter membrane protein; cell division protein FtsX complement(3647295..3648353) Escherichia coli HS 5594499 YP_001460258.1 CDS ftsE NC_009800.1 3648346 3649014 R ATP-binding protein of an ATP-binding cassette transporter; when bound to FtsX, FtsEX localizes to the cell division site and plays a role in the assembly or stability of the septal ring under low-salt growth conditions; cell division protein FtsE complement(3648346..3649014) Escherichia coli HS 5594500 YP_001460259.1 CDS ftsY NC_009800.1 3649017 3650513 R signal recognition protein receptor; functions in the targeting and insertion of membrane proteins; cell division protein FtsY complement(3649017..3650513) Escherichia coli HS 5594100 YP_001460260.1 CDS rsmD NC_009800.1 3650663 3651259 D catalyzes the methylation of 16S rRNA at position G966; 16S rRNA m(2)G966-methyltransferase 3650663..3651259 Escherichia coli HS 5594101 YP_001460261.1 CDS EcHS_A3665 NC_009800.1 3651249 3651518 D yhhL; identified by match to protein family HMM PF06611; hypothetical protein 3651249..3651518 Escherichia coli HS 5594102 YP_001460262.1 CDS EcHS_A3666 NC_009800.1 3651521 3651880 R identified by similarity to GB:CAG77246.1; hypothetical protein complement(3651521..3651880) Escherichia coli HS 5594103 YP_001460263.1 CDS EcHS_A3667 NC_009800.1 3652021 3652647 D identified by match to protein family HMM PF07947; hypothetical protein 3652021..3652647 Escherichia coli HS 5593635 YP_001460264.1 CDS zntA NC_009800.1 3652721 3654919 D P-type ATPase involved in the export of lead, cadmium, zinc and mercury; zinc/cadmium/mercury/lead-transporting ATPase 3652721..3654919 Escherichia coli HS 5593636 YP_001460265.1 CDS tusA NC_009800.1 3655021 3655266 R TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein SirA complement(3655021..3655266) Escherichia coli HS 5593637 YP_001460266.1 CDS EcHS_A3670 NC_009800.1 3655487 3656152 D yhhQ; identified by match to protein family HMM PF02592; match to protein family HMM TIGR00697; hypothetical protein 3655487..3656152 Escherichia coli HS 5593638 YP_001460267.1 CDS EcHS_A3671 NC_009800.1 3656225 3656782 D hypothetical protein 3656225..3656782 Escherichia coli HS 5594383 YP_001460268.1 CDS EcHS_A3672 NC_009800.1 3656786 3658045 R identified by match to protein family HMM PF07690; major facilitator superfamily transporter complement(3656786..3658045) Escherichia coli HS 5594384 YP_001460269.1 CDS EcHS_A3673 NC_009800.1 3658135 3659184 D yhhT; identified by match to protein family HMM PF01594; hypothetical protein 3658135..3659184 Escherichia coli HS 5594385 YP_001460270.1 CDS acpT NC_009800.1 3659239 3659826 D identified by similarity to SP:P37623; match to protein family HMM PF01648; holo-(acyl carrier protein) synthase 2 3659239..3659826 Escherichia coli HS 5594386 YP_001460271.1 CDS nikA NC_009800.1 3659937 3661511 D identified by match to protein family HMM PF00496; match to protein family HMM TIGR02294; nickel ABC transporter periplasmic nickel-binding protein NikA 3659937..3661511 Escherichia coli HS 5592774 YP_001460272.1 CDS nikB NC_009800.1 3661511 3662455 D with NikACDE is involved in nickel transport into the cell; nickel transporter permease NikB 3661511..3662455 Escherichia coli HS 5592775 YP_001460273.1 CDS nikC NC_009800.1 3662452 3663285 D with NikABDE is involved in nickel transport into the cell; nickel transporter permease NikC 3662452..3663285 Escherichia coli HS 5592776 YP_001460274.1 CDS nikD NC_009800.1 3663285 3664049 D with NikABCE is involved in nickel transport into the cell; nickel transporter ATP-binding protein NikD 3663285..3664049 Escherichia coli HS 5592777 YP_001460275.1 CDS nikE NC_009800.1 3664046 3664852 D with NikABCD is involved with nickel transport into the cell; nickel transporter ATP-binding protein NikE 3664046..3664852 Escherichia coli HS 5591714 YP_001460276.1 CDS nikR NC_009800.1 3664858 3665259 D Inhibits transcription at high concentrations of nickel; nickel responsive regulator 3664858..3665259 Escherichia coli HS 5591715 YP_001460277.1 CDS rhsB NC_009800.1 3665462 3669697 D identified by similarity to SP:P16917; match to protein family HMM PF03527; match to protein family HMM PF05593; match to protein family HMM TIGR01643; RhsB protein 3665462..3669697 Escherichia coli HS 5591716 YP_001460278.1 CDS EcHS_A3684 NC_009800.1 3671948 3673072 R identified by match to protein family HMM PF01061; ABC transporter ATP-binding protein complement(3671948..3673072) Escherichia coli HS 5594305 YP_001460279.1 CDS EcHS_A3685 NC_009800.1 3673072 3675807 R identified by match to protein family HMM PF00005; match to protein family HMM PF01061; ABC transporter ATP binding protein complement(3673072..3675807) Escherichia coli HS 5594306 YP_001460280.1 CDS EcHS_A3686 NC_009800.1 3675804 3676871 R identified by match to protein family HMM PF00529; MFP family transporter complement(3675804..3676871) Escherichia coli HS 5594307 YP_001460281.1 CDS EcHS_A3687 NC_009800.1 3677621 3677896 D identified by match to protein family HMM PF03811; IS1, transposase orfA 3677621..3677896 Escherichia coli HS 5594308 YP_001460282.1 CDS EcHS_A3688 NC_009800.1 3677815 3678318 D identified by match to protein family HMM PF03400; IS1, transposase orfB 3677815..3678318 Escherichia coli HS 5592722 YP_001460283.1 CDS EcHS_A3689 NC_009800.1 3678329 3678481 R identified by glimmer; hypothetical protein complement(3678329..3678481) Escherichia coli HS 5592723 YP_001460284.1 CDS EcHS_A3690 NC_009800.1 3678481 3678594 R identified by glimmer; hypothetical protein complement(3678481..3678594) Escherichia coli HS 5592724 YP_001460285.1 CDS EcHS_A3691 NC_009800.1 3678717 3679919 R yhiN; identified by match to protein family HMM PF01266; match to protein family HMM PF03486; match to protein family HMM PF07992; match to protein family HMM TIGR00275; pyridine nucleotide-disulfide oxidoreductase complement(3678717..3679919) Escherichia coli HS 5592725 YP_001460286.1 CDS pitA NC_009800.1 3680151 3681650 D identified by match to protein family HMM PF01384; low-affinity inorganic phosphate transporter 1 3680151..3681650 Escherichia coli HS 5594195 YP_001460287.1 CDS EcHS_A3693 NC_009800.1 3681704 3681832 D identified by glimmer; hypothetical protein 3681704..3681832 Escherichia coli HS 5594196 YP_001460288.1 CDS uspB NC_009800.1 3681895 3682230 R ppGpp-dependent, membrane associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress; universal stress protein UspB complement(3681895..3682230) Escherichia coli HS 5594197 YP_001460289.1 CDS uspA NC_009800.1 3682621 3683055 D identified by similarity to SP:P0AED0; match to protein family HMM PF00582; universal stress protein A 3682621..3683055 Escherichia coli HS 5594198 YP_001460290.1 CDS EcHS_A3696 NC_009800.1 3683373 3684842 D member of the POT family of peptide transporters; probable proton-dependent peptide transporter function; inner membrane transporter YhiP 3683373..3684842 Escherichia coli HS 5595303 YP_001460291.1 CDS EcHS_A3697 NC_009800.1 3684891 3685643 R predicted SAM-dependent methyltransferase; methyltransferase complement(3684891..3685643) Escherichia coli HS 5595304 YP_001460292.1 CDS prlC NC_009800.1 3685651 3687693 R identified by similarity to SP:P27298; match to protein family HMM PF01432; oligopeptidase A complement(3685651..3687693) Escherichia coli HS 5595305 YP_001460293.1 CDS yhiR NC_009800.1 3687896 3688738 D identified by similarity to SP:P37634; match to protein family HMM PF04378; DNA utilization protein YhiR 3687896..3688738 Escherichia coli HS 5595306 YP_001460294.1 CDS gor NC_009800.1 3688810 3690162 D catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 3688810..3690162 Escherichia coli HS 5594168 YP_001460295.1 CDS EcHS_A3701 NC_009800.1 3690216 3690365 R identified by glimmer; hypothetical protein complement(3690216..3690365) Escherichia coli HS 5594169 YP_001460296.1 CDS EcHS_A3702 NC_009800.1 3690613 3690774 R identified by glimmer; hypothetical protein complement(3690613..3690774) Escherichia coli HS 5594170 YP_001460297.1 CDS arsR NC_009800.1 3691039 3691392 D regulates the expression of of the arsRBC involved in resistance to arsenic; DNA-binding transcriptional repressor ArsR 3691039..3691392 Escherichia coli HS 5594171 YP_001460298.1 CDS arsB NC_009800.1 3691446 3692735 D identified by match to protein family HMM PF02040; match to protein family HMM PF03600; match to protein family HMM TIGR00935; arsenical pump membrane protein 3691446..3692735 Escherichia coli HS 5593883 YP_001460299.1 CDS arsC2 NC_009800.1 3692748 3693173 D identified by similarity to SP:P08692; match to protein family HMM PF03960; match to protein family HMM TIGR00014; arsenate reductase 3692748..3693173 Escherichia coli HS 5593884 YP_001460300.1 CDS EcHS_A3706 NC_009800.1 3693228 3693392 D identified by similarity to GB:AAN82738.1; hypothetical protein 3693228..3693392 Escherichia coli HS 5593885 YP_001460301.1 CDS EcHS_A3707 NC_009800.1 3693802 3694917 D yhiS; hypothetical protein 3693802..3694917 Escherichia coli HS 5593886 YP_001460302.1 CDS EcHS_A3708 NC_009800.1 3695272 3695838 D identified by match to protein family HMM PF03843; match to protein family HMM TIGR00752; Slp family outer membrane lipoprotein 3695272..3695838 Escherichia coli HS 5593971 YP_001460303.1 CDS dctR NC_009800.1 3695994 3696524 D yhiF; identified by similarity to SP:P37195; match to protein family HMM PF00196; transcriptional regulator DctR 3695994..3696524 Escherichia coli HS 5593972 YP_001460304.1 CDS EcHS_A3710 NC_009800.1 3696566 3697213 R inner membrane protein involved in cell density-dependent acid resistance; part of the acid fitness island (AFI) of E. coli; Mg(2+) transport ATPase complement(3696566..3697213) Escherichia coli HS 5593973 YP_001460305.1 CDS hdeB NC_009800.1 3697277 3697615 R acid-resistance protein complement(3697277..3697615) Escherichia coli HS 5593974 YP_001460306.1 CDS EcHS_A3712 NC_009800.1 3697719 3698051 R inactive form; acid-resistance protein complement(3697719..3698051) Escherichia coli HS 5594063 YP_001460307.1 CDS EcHS_A3713 NC_009800.1 3698306 3698878 D hdeD; identified by similarity to SP:P0AET7; acid-resistance membrane protein 3698306..3698878 Escherichia coli HS 5594064 YP_001460308.1 CDS gadE NC_009800.1 3699677 3700204 D yhiE; identified by similarity to SP:P63204; transcriptional regulator GadE 3699677..3700204 Escherichia coli HS 5594065 YP_001460309.1 CDS mdtE NC_009800.1 3700543 3701700 D with MdtF and tolC is involved in resistance to rhodamine 6G, erythromycin, doxorubicin and other compounds; multidrug efflux system protein MdtE 3700543..3701700 Escherichia coli HS 5594066 YP_001460310.1 CDS mdtF NC_009800.1 3701725 3704838 D identified by similarity to SP:P37637; match to protein family HMM PF00873; match to protein family HMM TIGR00915; multidrug resistance protein MdtF 3701725..3704838 Escherichia coli HS 5593978 YP_001460311.1 CDS gadW NC_009800.1 3705201 3705929 R identified by similarity to SP:P63201; match to protein family HMM PF00165; transcriptional regulator GadW complement(3705201..3705929) Escherichia coli HS 5593979 YP_001460312.1 CDS EcHS_A3718 NC_009800.1 3706002 3706109 R identified by glimmer; hypothetical protein complement(3706002..3706109) Escherichia coli HS 5593980 YP_001460313.1 CDS gadX NC_009800.1 3706297 3707121 R regulates genes in response to acid and/or during stationary phase; DNA-binding transcriptional regulator GadX complement(3706297..3707121) Escherichia coli HS 5593934 YP_001460314.1 CDS gadA NC_009800.1 3707491 3708891 R identified by match to protein family HMM PF00282; match to protein family HMM TIGR01788; glutamate decarboxylase GadA complement(3707491..3708891) Escherichia coli HS 5593935 YP_001460315.1 CDS EcHS_A3721 NC_009800.1 3709102 3710499 R identified by match to protein family HMM PF03150; di-haem cytochrome c peroxidase complement(3709102..3710499) Escherichia coli HS 5593936 YP_001460316.1 CDS treF NC_009800.1 3710904 3712553 D cytoplasmic; catalyzes the hydrolysis of trehalose to glucose; trehalase 3710904..3712553 Escherichia coli HS 5595268 YP_001460317.1 CDS EcHS_A3723 NC_009800.1 3712604 3713206 R identified by match to protein family HMM PF00196; match to protein family HMM PF08281; LuxR family transcriptional regulator complement(3712604..3713206) Escherichia coli HS 5595269 YP_001460318.1 CDS EcHS_A3724 NC_009800.1 3713726 3714625 D identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator 3713726..3714625 Escherichia coli HS 5595270 YP_001460319.1 CDS EcHS_A3725 NC_009800.1 3714674 3715687 D identified by match to protein family HMM PF03631; match to protein family HMM TIGR00766; ribonuclease 3714674..3715687 Escherichia coli HS 5595271 YP_001460320.1 CDS EcHS_A3726 NC_009800.1 3716098 3717420 D identified by match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM TIGR00883; MFS transporter metabolite:H+ symporter (MHS) family protein 3716098..3717420 Escherichia coli HS 5593755 YP_001460321.1 CDS EcHS_A3727 NC_009800.1 3717602 3719662 R identified by match to protein family HMM PF05170; AsmA family protein complement(3717602..3719662) Escherichia coli HS 5593756 YP_001460322.1 CDS EcHS_A3728 NC_009800.1 3719732 3720499 R in Escherichia coli this protein is involved in flagellar function; diguanylate phosphodiesterase complement(3719732..3720499) Escherichia coli HS 5593757 YP_001460323.1 CDS kdgK NC_009800.1 3720731 3721660 D identified by similarity to SP:P45416; match to protein family HMM PF00294; 2-dehydro-3-deoxygluconokinase 3720731..3721660 Escherichia coli HS 5593758 YP_001460324.1 CDS EcHS_A3730 NC_009800.1 3721756 3723252 R yhjJ; identified by match to protein family HMM PF00675; match to protein family HMM PF05193; M16 family peptidase complement(3721756..3723252) Escherichia coli HS 5593872 YP_001460325.1 CDS dctA NC_009800.1 3723473 3724759 R involved in the transport of C4-dicarboxylates across the membrane; C4-dicarboxylate transporter DctA complement(3723473..3724759) Escherichia coli HS 5593873 YP_001460326.1 CDS EcHS_A3732 NC_009800.1 3724942 3726897 R HmsP in Yersinia pestis plays a role in invasion of epithelial cells; the EAL-domain portion of HmsP from Y. pestis shows phosphodiesterase activity which is required for the inhibition of biofilm formation; inner membrane protein; similar to a phosphodiesterase from E. coli; phosphodiesterase complement(3724942..3726897) Escherichia coli HS 5593874 YP_001460327.1 CDS EcHS_A3734 NC_009800.1 3727012 3727881 R identified by similarity to SP:P37650; match to protein family HMM PF05420; cellulose synthase operon protein C, truncation complement(3727012..3727881) Escherichia coli HS 5593875 YP_001460328.1 CDS EcHS_A3733 NC_009800.1 3727832 3728398 D identified by similarity to SP:P37659; hypothetical protein 3727832..3728398 Escherichia coli HS 5593317 YP_001460329.1 CDS EcHS_A3736 NC_009800.1 3729451 3729726 R identified by glimmer; hypothetical protein complement(3729451..3729726) Escherichia coli HS 5593319 YP_001460330.1 CDS EcHS_A3737 NC_009800.1 3729723 3729884 R identified by glimmer; hypothetical protein complement(3729723..3729884) Escherichia coli HS 5593320 YP_001460331.1 CDS EcHS_A3738 NC_009800.1 3730034 3731305 D identified by match to protein family HMM TIGR00814; serine transporter family protein 3730034..3731305 Escherichia coli HS 5593765 YP_001460332.1 CDS dppF NC_009800.1 3731335 3732339 R Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides; dipeptide transporter ATP-binding subunit complement(3731335..3732339) Escherichia coli HS 5593766 YP_001460333.1 CDS dppD NC_009800.1 3732336 3733319 R DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF; dipeptide transporter ATP-binding subunit complement(3732336..3733319) Escherichia coli HS 5593767 YP_001460334.1 CDS dppC NC_009800.1 3733330 3734232 R identified by match to protein family HMM PF00528; dipeptide transporter complement(3733330..3734232) Escherichia coli HS 5593768 YP_001460335.1 CDS dppB NC_009800.1 3734242 3735261 R transports peptides consisting of two or three amino acids; dipeptide transporter permease DppB complement(3734242..3735261) Escherichia coli HS 5593887 YP_001460337.1 CDS dppA NC_009800.1 3735569 3737176 R identified by match to protein family HMM PF00496; dipeptide ABC transporter periplasmic dipeptide-binding protein complement(3735569..3737176) Escherichia coli HS 5593889 YP_001460338.1 CDS EcHS_A3745 NC_009800.1 3737365 3737520 D identified by glimmer; hypothetical protein 3737365..3737520 Escherichia coli HS 5593890 YP_001460339.1 CDS EcHS_A3747 NC_009800.1 3738087 3739778 R catalyzes the addition of a phosphoethanolamine group to the outer Kdo residue of lipopolysaccharide; phosphoethanolamine transferase complement(3738087..3739778) Escherichia coli HS 5593678 YP_001460340.1 CDS EcHS_A3748 NC_009800.1 3740102 3741310 R identified by match to protein family HMM PF07690; match to protein family HMM TIGR00890; major facilitator family transporter complement(3740102..3741310) Escherichia coli HS 5593679 YP_001460341.1 CDS EcHS_A3750 NC_009800.1 3741539 3742237 R identified by similarity to SP:P37663; hypothetical protein complement(3741539..3742237) Escherichia coli HS 5593517 YP_001460342.1 CDS tag NC_009800.1 3742395 3742958 D constitutive, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine; 3-methyl-adenine DNA glycosylase I 3742395..3742958 Escherichia coli HS 5593518 YP_001460343.1 CDS EcHS_A3751 NC_009800.1 3742955 3743395 D identified by match to protein family HMM PF00583; hypothetical protein 3742955..3743395 Escherichia coli HS 5593519 YP_001460344.1 CDS bisC NC_009800.1 3743364 3745697 R identified by similarity to SP:P20099; match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM TIGR00509; biotin sulfoxide reductase complement(3743364..3745697) Escherichia coli HS 5593520 YP_001460345.1 CDS EcHS_A3753 NC_009800.1 3745850 3746509 D identified by similarity to SP:P37665; match to protein family HMM PF00691; match to protein family HMM PF05433; outer membrane lipoprotein 3745850..3746509 Escherichia coli HS 5593567 YP_001460346.1 CDS tkrA NC_009800.1 3746613 3747587 D identified by similarity to SP:P37666; match to protein family HMM PF00389; match to protein family HMM PF02826; 2-ketogluconate reductase 3746613..3747587 Escherichia coli HS 5593568 YP_001460347.1 CDS EcHS_A3755 NC_009800.1 3747637 3748347 R yiaF; lipoprotein complement(3747637..3748347) Escherichia coli HS 5593569 YP_001460348.1 CDS EcHS_A3756 NC_009800.1 3748781 3749071 D yiaG; identified by similarity to SP:P0A9V5; transcriptional regulator 3748781..3749071 Escherichia coli HS 5593570 YP_001460349.1 CDS EcHS_A3757 NC_009800.1 3749352 3749564 D identified by match to protein family HMM PF00313; major cold shock protein 3749352..3749564 Escherichia coli HS 5593580 YP_001460350.1 CDS hokA NC_009800.1 3749751 3749903 R identified by similarity to SP:P37305; match to protein family HMM PF01848; small toxic polypeptide complement(3749751..3749903) Escherichia coli HS 5593581 YP_001460351.1 CDS EcHS_A3759 NC_009800.1 3749983 3750504 D identified by similarity to GB:AAL72400.1; IS150, transposase orfA 3749983..3750504 Escherichia coli HS 5593582 YP_001460352.1 CDS EcHS_A3760 NC_009800.1 3750501 3751352 D identified by similarity to GB:AAB18535.2; match to protein family HMM PF00665; IS150, transposase orfB 3750501..3751352 Escherichia coli HS 5593583 YP_001460353.1 CDS glyS NC_009800.1 3751631 3753700 R glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta complement(3751631..3753700) Escherichia coli HS 5593492 YP_001460354.1 CDS glyQ NC_009800.1 3753710 3754621 R glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha complement(3753710..3754621) Escherichia coli HS 5593493 YP_001460355.1 CDS EcHS_A3763 NC_009800.1 3754716 3755015 R hypothetical protein complement(3754716..3755015) Escherichia coli HS 5593494 YP_001460356.1 CDS EcHS_A3764 NC_009800.1 3755190 3756185 D yiaH; identified by match to protein family HMM PF01757; acyltransferase 3755190..3756185 Escherichia coli HS 5593495 YP_001460357.1 CDS EcHS_A3765 NC_009800.1 3756227 3756664 R yiaA; identified by match to protein family HMM PF05360; hypothetical protein complement(3756227..3756664) Escherichia coli HS 5593476 YP_001460358.1 CDS EcHS_A3766 NC_009800.1 3756710 3757051 R yiaB; identified by match to protein family HMM PF05360; hypothetical protein complement(3756710..3757051) Escherichia coli HS 5593477 YP_001460359.1 CDS xylB NC_009800.1 3757220 3758674 R identified by similarity to SP:P29444; match to protein family HMM PF00370; match to protein family HMM PF02782; match to protein family HMM TIGR01312; xylulokinase complement(3757220..3758674) Escherichia coli HS 5593478 YP_001460360.1 CDS xylA NC_009800.1 3758746 3760068 R catalyzes the interconversion of D-xylose to D-xylulose; xylose isomerase complement(3758746..3760068) Escherichia coli HS 5593479 YP_001460361.1 CDS xylF NC_009800.1 3760434 3761426 D periplasmic substrate-binding component of the ATP-dependent xylose transport system; high affinity; D-xylose transporter subunit XylF 3760434..3761426 Escherichia coli HS 5593639 YP_001460362.1 CDS xylG NC_009800.1 3761504 3763045 D with XylFH is part of the high affinity xylose ABC transporter; xylose transporter ATP-binding subunit 3761504..3763045 Escherichia coli HS 5593640 YP_001460363.1 CDS xylH NC_009800.1 3763023 3764204 D identified by match to protein family HMM PF02653; D-xylose ABC transporter permease 3763023..3764204 Escherichia coli HS 5593641 YP_001460364.1 CDS xylR NC_009800.1 3764282 3765460 D identified by match to protein family HMM PF00165; xylose operon regulatory protein 3764282..3765460 Escherichia coli HS 5593642 YP_001460365.1 CDS bax NC_009800.1 3765656 3766480 R identified by match to protein family HMM PF01832; hypothetical protein complement(3765656..3766480) Escherichia coli HS 5592851 YP_001460366.1 CDS malS NC_009800.1 3766800 3768830 D periplasmic enzyme that degrades maltodextrins that enter via the outer membrane porin LamB; hydrolyzes alpha-(1,4) glycosidic linkages; contains internal disulfide bonds; periplasmic alpha-amylase precursor 3766800..3768830 Escherichia coli HS 5592852 YP_001460367.1 CDS avtA NC_009800.1 3769008 3770261 D transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis; valine--pyruvate transaminase 3769008..3770261 Escherichia coli HS 5592853 YP_001460368.1 CDS EcHS_A3776 NC_009800.1 3770265 3770393 D identified by similarity to GB:ABB67500.1; hypothetical protein 3770265..3770393 Escherichia coli HS 5592854 YP_001460369.1 CDS EcHS_A3777 NC_009800.1 3770412 3770885 R yiaI; identified by match to protein family HMM PF00037; 4Fe-4S ferredoxin complement(3770412..3770885) Escherichia coli HS 5592985 YP_001460370.1 CDS EcHS_A3778 NC_009800.1 3770987 3771799 R identified by match to protein family HMM PF01614; match to protein family HMM PF09339; IclR family transcriptional regulator complement(3770987..3771799) Escherichia coli HS 5592986 YP_001460371.1 CDS dlgD NC_009800.1 3772036 3773034 D NAD(P)H-dependent; catalyzes the reduction of 2,3-diketo-L-gulonate to 3-keto-L-gulonate; 2,3-diketo-L-gulonate reductase 3772036..3773034 Escherichia coli HS 5592987 YP_001460372.1 CDS EcHS_A3780 NC_009800.1 3773085 3773513 D identified by match to protein family HMM PF04074; match to protein family HMM TIGR00022; hypothetical protein 3773085..3773513 Escherichia coli HS 5592988 YP_001460373.1 CDS EcHS_A3781 NC_009800.1 3773631 3774104 D membrane-spanning protein involved in uptake of 2,3-diketo-L-gulonate; part of the tri-partite ATP-independent periplasmic transport system (TRAP) YiaMNO; 2,3-diketo-L-gulonate TRAP transporter small permease YiaM 3773631..3774104 Escherichia coli HS 5595243 YP_001460374.1 CDS EcHS_A3782 NC_009800.1 3774107 3775384 D identified by match to protein family HMM PF06808; match to protein family HMM TIGR00786; TRAP transporter DctM family protein 3774107..3775384 Escherichia coli HS 5595244 YP_001460375.1 CDS EcHS_A3783 NC_009800.1 3775397 3776383 D identified by match to protein family HMM PF03480; match to protein family HMM TIGR00787; TRAP transporter solute receptor DctP family protein 3775397..3776383 Escherichia coli HS 5595245 YP_001460376.1 CDS lyx NC_009800.1 3776387 3777883 D identified by similarity to SP:P37677; match to protein family HMM PF00370; match to protein family HMM PF02782; cryptic L-xylulose kinase 3776387..3777883 Escherichia coli HS 5595246 YP_001460377.1 CDS sgbH NC_009800.1 3777880 3778542 D catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate; 3-keto-L-gulonate-6-phosphate decarboxylase 3777880..3778542 Escherichia coli HS 5593442 YP_001460378.1 CDS EcHS_A3786 NC_009800.1 3778535 3779395 D L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate; L-xylulose 5-phosphate 3-epimerase 3778535..3779395 Escherichia coli HS 5593443 YP_001460379.1 CDS sgbE NC_009800.1 3779389 3780084 D catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 3779389..3780084 Escherichia coli HS 5593444 YP_001460380.1 CDS EcHS_A3788 NC_009800.1 3780431 3781171 R identified by similarity to SP:P0A908; match to protein family HMM PF06629; match to protein family HMM TIGR03304; MltA-interacting protein MipA complement(3780431..3781171) Escherichia coli HS 5593445 YP_001460381.1 CDS EcHS_A3789 NC_009800.1 3781295 3782269 D identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator 3781295..3782269 Escherichia coli HS 5595171 YP_001460382.1 CDS EcHS_A3790 NC_009800.1 3782266 3783402 R identified by match to protein family HMM PF00529; membrane fusion protein family protein complement(3782266..3783402) Escherichia coli HS 5595172 YP_001460383.1 CDS EcHS_A3791 NC_009800.1 3783408 3783731 R yiaW; identified by similarity to GB:AAF95962.1; hypothetical protein complement(3783408..3783731) Escherichia coli HS 5595173 YP_001460384.1 CDS EcHS_A3792 NC_009800.1 3783845 3784057 D identified by glimmer; hypothetical protein 3783845..3784057 Escherichia coli HS 5595174 YP_001460385.1 CDS aldB NC_009800.1 3784276 3785814 R identified by similarity to SP:P37685; match to protein family HMM PF00171; aldehyde dehydrogenase complement(3784276..3785814) Escherichia coli HS 5591730 YP_001460386.1 CDS adhB NC_009800.1 3785979 3787130 R identified by match to protein family HMM PF00465; alcohol dehydrogenase complement(3785979..3787130) Escherichia coli HS 5591731 YP_001460387.1 CDS selB NC_009800.1 3787320 3789164 R identified by similarity to SP:P14081; match to protein family HMM PF00009; match to protein family HMM PF03144; match to protein family HMM PF09106; match to protein family HMM PF09107; match to protein family HMM TIGR00475; selenocysteinyl-tRNA-specific translation factor complement(3787320..3789164) Escherichia coli HS 5591732 YP_001460388.1 CDS selA NC_009800.1 3789161 3790552 R catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis; selenocysteine synthase complement(3789161..3790552) Escherichia coli HS 5591733 YP_001460389.1 CDS EcHS_A3798 NC_009800.1 3790650 3791258 R identified by match to protein family HMM PF00043; match to protein family HMM PF02798; glutathione S-transferase complement(3790650..3791258) Escherichia coli HS 5592637 YP_001460390.1 CDS EcHS_A3797 NC_009800.1 3791257 3791400 D identified by glimmer; hypothetical protein 3791257..3791400 Escherichia coli HS 5592638 YP_001460391.1 CDS EcHS_A3801 NC_009800.1 3792868 3793710 D yibA; identified by match to protein family HMM PF03130; hypothetical protein 3792868..3793710 Escherichia coli HS 5592640 YP_001460392.1 CDS EcHS_A3802 NC_009800.1 3793752 3794696 D identified by match to protein family HMM PF03527; Rhs family protein 3793752..3794696 Escherichia coli HS 5591768 YP_001460393.1 CDS EcHS_A3803 NC_009800.1 3796773 3797909 R identified by match to protein family HMM PF00529; membrane fusion protein family protein complement(3796773..3797909) Escherichia coli HS 5591769 YP_001460394.1 CDS EcHS_A3804 NC_009800.1 3797912 3798274 R yibI; identified by similarity to GB:AAN82851.1; hypothetical protein complement(3797912..3798274) Escherichia coli HS 5591770 YP_001460395.1 CDS EcHS_A3805 NC_009800.1 3798300 3798392 D identified by glimmer; hypothetical protein 3798300..3798392 Escherichia coli HS 5591771 YP_001460396.1 CDS mtlA NC_009800.1 3798811 3800724 D identified by similarity to SP:P00550; match to protein family HMM PF00359; match to protein family HMM PF02302; match to protein family HMM PF02378; match to protein family HMM TIGR00851; PTS system, mannitol-specific IIABC component 3798811..3800724 Escherichia coli HS 5593041 YP_001460397.1 CDS mtlD NC_009800.1 3800954 3802102 D identified by match to protein family HMM PF01232; match to protein family HMM PF08125; mannitol-1-phosphate 5-dehydrogenase 3800954..3802102 Escherichia coli HS 5593042 YP_001460398.1 CDS mtlR NC_009800.1 3802102 3802689 D Acts as a repressor of the mtlAD operon; mannitol repressor protein 3802102..3802689 Escherichia coli HS 5593043 YP_001460399.1 CDS EcHS_A3809 NC_009800.1 3802701 3802910 R identified by similarity to SP:P0AA60; similarity to RF:NP_462588.1; hypothetical protein complement(3802701..3802910) Escherichia coli HS 5593044 YP_001460400.1 CDS EcHS_A3810 NC_009800.1 3803195 3803557 D yibL; hypothetical protein 3803195..3803557 Escherichia coli HS 5593160 YP_001460401.1 CDS EcHS_A3811 NC_009800.1 3803643 3803735 R identified by glimmer; hypothetical protein complement(3803643..3803735) Escherichia coli HS 5593161 YP_001460402.1 CDS EcHS_A3812 NC_009800.1 3803887 3804030 R NULL; identified by glimmer; hypothetical protein complement(3803887..3804030) Escherichia coli HS 5593162 YP_001460403.1 CDS EcHS_A3813 NC_009800.1 3804101 3804784 D NULL; lipoprotein 3804101..3804784 Escherichia coli HS 5593163 YP_001460404.1 CDS EcHS_A3814 NC_009800.1 3804828 3809852 D identified by match to protein family HMM PF03895; match to protein family HMM PF05658; match to protein family HMM PF05662; hemagglutinin 3804828..3809852 Escherichia coli HS 5593200 YP_001460405.1 CDS lldP NC_009800.1 3810220 3811875 D identified by match to protein family HMM PF02652; match to protein family HMM TIGR00795; L-lactate permease 3810220..3811875 Escherichia coli HS 5593201 YP_001460406.1 CDS EcHS_A3816 NC_009800.1 3811875 3812651 D represses the lctPRD operon; DNA-binding transcriptional repressor LldR 3811875..3812651 Escherichia coli HS 5593202 YP_001460407.1 CDS lldD NC_009800.1 3812648 3813838 D flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration; L-lactate dehydrogenase 3812648..3813838 Escherichia coli HS 5593203 YP_001460408.1 CDS EcHS_A3818 NC_009800.1 3813992 3814465 D member of the SPOUT superfamily of RNA methyltransferases; no methyltransferase activity observed with certain tRNA substrates; tRNA/rRNA methyltransferase YibK 3813992..3814465 Escherichia coli HS 5592945 YP_001460409.1 CDS cysE NC_009800.1 3814518 3815339 R catalyzes the O-acetylation of serine; serine acetyltransferase complement(3814518..3815339) Escherichia coli HS 5592946 YP_001460410.1 CDS gpsA NC_009800.1 3815419 3816438 R catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase complement(3815419..3816438) Escherichia coli HS 5592947 YP_001460411.1 CDS secB NC_009800.1 3816438 3816905 R molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB complement(3816438..3816905) Escherichia coli HS 5592948 YP_001460412.1 CDS grxC NC_009800.1 3816968 3817219 R identified by similarity to SP:P0AC62; match to protein family HMM PF00462; match to protein family HMM TIGR02181; glutaredoxin 3 complement(3816968..3817219) Escherichia coli HS 5593404 YP_001460413.1 CDS EcHS_A3823 NC_009800.1 3817361 3817792 R identified by match to protein family HMM PF00581; rhodanese domain-containing protein complement(3817361..3817792) Escherichia coli HS 5593405 YP_001460414.1 CDS gpmI NC_009800.1 3818037 3819581 D catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate; phosphoglyceromutase 3818037..3819581 Escherichia coli HS 5593406 YP_001460415.2 CDS EcHS_A3825 NC_009800.1 3819591 3820874 D identified by match to protein family HMM PF01551; hypothetical protein 3819591..3820874 Escherichia coli HS 5593407 YP_001460416.1 CDS EcHS_A3826 NC_009800.1 3820878 3821837 D identified by match to protein family HMM PF04748; polysaccharide deacetylase 3820878..3821837 Escherichia coli HS 5593373 YP_001460417.1 CDS EcHS_A3827 NC_009800.1 3821824 3822858 R identified by match to protein family HMM PF00535; glycosyl transferase complement(3821824..3822858) Escherichia coli HS 5593374 YP_001460418.1 CDS tdh NC_009800.1 3823097 3824122 R converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism; L-threonine 3-dehydrogenase complement(3823097..3824122) Escherichia coli HS 5593375 YP_001460419.1 CDS kbl NC_009800.1 3824132 3825328 R catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine; 2-amino-3-ketobutyrate CoA ligase complement(3824132..3825328) Escherichia coli HS 5593376 YP_001460420.1 CDS rfaD NC_009800.1 3825542 3826474 D catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose; ADP-L-glycero-D-manno-heptose-6-epimerase 3825542..3826474 Escherichia coli HS 5593280 YP_001460421.1 CDS rfaF NC_009800.1 3826484 3827530 D catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core; ADP-heptose:LPS heptosyltransferase II 3826484..3827530 Escherichia coli HS 5593281 YP_001460422.1 CDS rfaC NC_009800.1 3827534 3828505 D identified by match to protein family HMM PF01075; match to protein family HMM TIGR02193; ADP-heptose:LPS heptosyl transferase I 3827534..3828505 Escherichia coli HS 5593282 YP_001460423.1 CDS EcHS_A3833 NC_009800.1 3828575 3829828 R identified by match to protein family HMM PF04932; O-antigen polymerase complement(3828575..3829828) Escherichia coli HS 5593283 YP_001460424.1 CDS EcHS_A3834 NC_009800.1 3829874 3830857 R identified by match to protein family HMM PF00535; glycosyl transferase, group 2 family protein complement(3829874..3830857) Escherichia coli HS 5592837 YP_001460425.1 CDS waaW NC_009800.1 3830942 3831967 R identified by similarity to GB:AAC69673.1; match to protein family HMM PF01501; match to protein family HMM PF08437; lipopolysaccharide 1,2-galactosyltransferase complement(3830942..3831967) Escherichia coli HS 5592838 YP_001460426.1 CDS rfaY NC_009800.1 3831993 3832685 R identified by similarity to SP:P27240; match to protein family HMM PF06176; lipopolysaccharide core biosynthesis protein complement(3831993..3832685) Escherichia coli HS 5592839 YP_001460427.1 CDS rfaJ2 NC_009800.1 3832695 3833690 R identified by similarity to SP:P27129; match to protein family HMM PF01501; match to protein family HMM PF08437; lipopolysaccharide 1,2-glucosyltransferase complement(3832695..3833690) Escherichia coli HS 5592840 YP_001460428.1 CDS rfaI NC_009800.1 3833707 3834723 R identified by match to protein family HMM PF01501; match to protein family HMM PF08437; lipopolysaccharide 1,3-galactosyltransferase complement(3833707..3834723) Escherichia coli HS 5593296 YP_001460429.1 CDS rfaP NC_009800.1 3834739 3835536 R identified by match to protein family HMM PF06293; lipopolysaccharide core biosynthesis protein RfaP complement(3834739..3835536) Escherichia coli HS 5593297 YP_001460430.1 CDS rfaG NC_009800.1 3835529 3836653 R identified by similarity to SP:P25740; match to protein family HMM PF00534; lipopolysaccharide core biosynthesis protein RfaG complement(3835529..3836653) Escherichia coli HS 5593298 YP_001460431.1 CDS rfaQ NC_009800.1 3836650 3837708 R identified by similarity to SP:P25742; match to protein family HMM PF01075; match to protein family HMM TIGR02201; lipopolysaccharide core biosynthesis protein complement(3836650..3837708) Escherichia coli HS 5593299 YP_001460432.1 CDS waaA NC_009800.1 3838121 3839398 D catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A; 3-deoxy-D-manno-octulosonic-acid transferase 3838121..3839398 Escherichia coli HS 5592760 YP_001460433.1 CDS coaD NC_009800.1 3839406 3839885 D Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 3839406..3839885 Escherichia coli HS 5592761 YP_001460434.1 CDS mutM NC_009800.1 3839924 3840733 R Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase complement(3839924..3840733) Escherichia coli HS 5592762 YP_001460435.1 CDS rpmG NC_009800.1 3840831 3840998 R in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 complement(3840831..3840998) Escherichia coli HS 5592763 YP_001460436.1 CDS rpmB NC_009800.1 3841019 3841255 R required for 70S ribosome assembly; 50S ribosomal protein L28 complement(3841019..3841255) Escherichia coli HS 5592962 YP_001460437.1 CDS radC NC_009800.1 3841472 3842140 R Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC complement(3841472..3842140) Escherichia coli HS 5592963 YP_001460438.1 CDS coaBC NC_009800.1 3842312 3843532 D catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 3842312..3843532 Escherichia coli HS 5592964 YP_001460439.1 CDS dut NC_009800.1 3843513 3843968 D catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 3843513..3843968 Escherichia coli HS 5592965 YP_001460440.1 CDS slmA NC_009800.1 3844075 3844671 D FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly; nucleoid occlusion protein 3844075..3844671 Escherichia coli HS 5595014 YP_001460441.1 CDS pyrE NC_009800.1 3844708 3845349 R involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase complement(3844708..3845349) Escherichia coli HS 5595015 YP_001460442.1 CDS rph NC_009800.1 3845415 3846131 R RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH complement(3845415..3846131) Escherichia coli HS 5595016 YP_001460443.1 CDS EcHS_A3853 NC_009800.1 3846258 3847121 D identified by match to protein family HMM PF03755; match to protein family HMM PF08340; match to protein family HMM TIGR00255; hypothetical protein 3846258..3847121 Escherichia coli HS 5595017 YP_001460444.1 CDS EcHS_A3854 NC_009800.1 3847138 3847278 R identified by glimmer; hypothetical protein complement(3847138..3847278) Escherichia coli HS 5592934 YP_001460445.1 CDS EcHS_A3857 NC_009800.1 3848457 3849074 D identified by match to protein family HMM PF03458; hypothetical protein 3848457..3849074 Escherichia coli HS 5592936 YP_001460446.1 CDS ligB NC_009800.1 3849071 3850759 R this ligase is similar to LigA but it lacks the C-terminal BRCT domain; catalyzes strand joining of nicked DNA in the presence of a divalent cation and NAD+; NAD-dependent DNA ligase LigB complement(3849071..3850759) Escherichia coli HS 5592937 YP_001460447.1 CDS gmk NC_009800.1 3851011 3851634 D Essential for recycling GMP and indirectly, cGMP; guanylate kinase 3851011..3851634 Escherichia coli HS 5593061 YP_001460448.1 CDS rpoZ NC_009800.1 3851689 3851964 D promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 3851689..3851964 Escherichia coli HS 5593062 YP_001460449.1 CDS spoT NC_009800.1 3851983 3854091 D identified by similarity to SP:P17580; match to protein family HMM PF01966; match to protein family HMM PF02824; match to protein family HMM PF04607; match to protein family HMM TIGR00691; bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 3851983..3854091 Escherichia coli HS 5593063 YP_001460450.1 CDS trmH NC_009800.1 3854098 3854787 D specifically modifies tRNA at position G18; tRNA guanosine-2'-O-methyltransferase 3854098..3854787 Escherichia coli HS 5593064 YP_001460451.1 CDS recG NC_009800.1 3854793 3856874 D catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 3854793..3856874 Escherichia coli HS 5593009 YP_001460452.1 CDS gltS NC_009800.1 3857043 3858248 R identified by similarity to SP:P0AER8; match to protein family HMM PF03616; match to protein family HMM TIGR00210; sodium/glutamate symporter complement(3857043..3858248) Escherichia coli HS 5593010 YP_001460453.1 CDS yicE NC_009800.1 3858528 3859919 D identified by match to protein family HMM PF00860; match to protein family HMM TIGR00801; xanthine permease 3858528..3859919 Escherichia coli HS 5593011 YP_001460454.1 CDS EcHS_A3866 NC_009800.1 3860040 3861749 D yicH; identified by match to protein family HMM PF05170; AsmA family protein 3860040..3861749 Escherichia coli HS 5593012 YP_001460455.1 CDS yicI NC_009800.1 3861802 3864120 R catalyzes the transfer of alpha-xylosyl residue from alpha-xyloside to xylose, glucose, mannose, fructose, maltose, isomaltose, nigerose, kojibiose, sucrose, and trehalose; shows higher activity against alpha-xylosyl fluoride, isoprimeverose (6-O-alpha-xylopyranosyl-glucopyranose), and alpha-xyloside in xyloglucan oligosaccharides; alpha-xylosidase YicI complement(3861802..3864120) Escherichia coli HS 5592797 YP_001460456.1 CDS EcHS_A3868 NC_009800.1 3864130 3865569 R may be involved in the transport of galactosides-pentoses-hexuronides; transporter complement(3864130..3865569) Escherichia coli HS 5592798 YP_001460457.1 CDS EcHS_A3870 NC_009800.1 3866005 3866154 D identified by glimmer; hypothetical protein 3866005..3866154 Escherichia coli HS 5592800 YP_001460458.1 CDS setC NC_009800.1 3866536 3867720 D identified by similarity to SP:P31436; match to protein family HMM PF07690; match to protein family HMM TIGR00899; sugar efflux transporter C 3866536..3867720 Escherichia coli HS 5592340 YP_001460459.1 CDS EcHS_A3872 NC_009800.1 3867831 3868754 D identified by match to protein family HMM PF00892; match to protein family HMM TIGR00950; carboxylate/amino acid/amine transporter 3867831..3868754 Escherichia coli HS 5592341 YP_001460460.1 CDS nlpA NC_009800.1 3868758 3869576 R identified by similarity to SP:P04846; match to protein family HMM PF03180; match to protein family HMM TIGR00363; cytoplasmic membrane lipoprotein-28 complement(3868758..3869576) Escherichia coli HS 5592342 YP_001460461.1 CDS EcHS_A3874 NC_009800.1 3869798 3870091 D identified by similarity to SP:Q5PC60; hypothetical protein 3869798..3870091 Escherichia coli HS 5592361 YP_001460462.1 CDS nepI NC_009800.1 3870132 3871487 R experimental results in Escherichia coli suggest that this gene encodes an inosine export protein; member of major facilitator superfamily; MFS; ribonucleoside transporter complement(3870132..3871487) Escherichia coli HS 5592362 YP_001460463.1 CDS EcHS_A3876 NC_009800.1 3871533 3871985 R yicN; identified by match to protein family HMM PF06711; hypothetical protein complement(3871533..3871985) Escherichia coli HS 5592363 YP_001460464.1 CDS EcHS_A3877 NC_009800.1 3872038 3873450 R yicO; identified by match to protein family HMM PF00860; match to protein family HMM PF00916; sulfate permease inorganic anion transporter complement(3872038..3873450) Escherichia coli HS 5592364 YP_001460465.1 CDS ade NC_009800.1 3873547 3875313 D catalyzes the formation of hypoxanthine from adenine; in E. coli this activity has been detected in mutant strains but not in wild type; cryptic adenine deaminase 3873547..3875313 Escherichia coli HS 5592916 YP_001460466.1 CDS uhpT NC_009800.1 3875358 3876749 R cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate; sugar phosphate antiporter complement(3875358..3876749) Escherichia coli HS 5592917 YP_001460467.1 CDS uhpC NC_009800.1 3876887 3878206 R membrane protein regulates uhpT expression; regulatory protein UhpC complement(3876887..3878206) Escherichia coli HS 5592918 YP_001460468.1 CDS uhpB NC_009800.1 3878216 3879709 R Member of the two-component regulatory system UhpB/UhpA involved in the regulation of the uptake of hexose ph; sensory histidine kinase UhpB complement(3878216..3879709) Escherichia coli HS 5592919 YP_001460469.1 CDS uhpA NC_009800.1 3879718 3880308 R response regulator in two-component regulatory system wtih UhpB; phosphorylated UhpA is a positive activator uhpT, a hexose phosphates transporter; DNA-binding transcriptional activator UhpA complement(3879718..3880308) Escherichia coli HS 5592981 YP_001460470.1 CDS ilvN NC_009800.1 3880383 3880673 R with IlvB catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase small subunit; acetolactate synthase 1 regulatory subunit complement(3880383..3880673) Escherichia coli HS 5592982 YP_001460471.1 CDS ilvB NC_009800.1 3880677 3882365 R identified by similarity to SP:P08142; match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; match to protein family HMM TIGR00118; acetolactate synthase catalytic subunit complement(3880677..3882365) Escherichia coli HS 5592983 YP_001460472.1 CDS ivbL NC_009800.1 3882471 3882569 R identified by similarity to SP:P03061; match to protein family HMM PF08049; ilvB operon leader peptide complement(3882471..3882569) Escherichia coli HS 5592984 YP_001460473.1 CDS emrD NC_009800.1 3883503 3884687 D multidrug efflux protein involved in adaptation to low energy shock; multidrug resistance protein D 3883503..3884687 Escherichia coli HS 5592823 YP_001460474.1 CDS EcHS_A3887 NC_009800.1 3884695 3885192 R hypothetical protein complement(3884695..3885192) Escherichia coli HS 5592824 YP_001460475.1 CDS EcHS_A3888 NC_009800.1 3885189 3885551 R yidG; hypothetical protein complement(3885189..3885551) Escherichia coli HS 5592825 YP_001460476.1 CDS EcHS_A3889 NC_009800.1 3885541 3885888 R yidH; identified by match to protein family HMM PF02656; hypothetical protein complement(3885541..3885888) Escherichia coli HS 5592826 YP_001460477.1 CDS EcHS_A3890 NC_009800.1 3886058 3887266 R identified by match to protein family HMM PF01385; match to protein family HMM PF07282; match to protein family HMM TIGR01766; IS605 family transposase OrfB complement(3886058..3887266) Escherichia coli HS 5595081 YP_001460478.1 CDS glvA NC_009800.1 3887836 3889158 R identified by similarity to SP:P54716; match to protein family HMM PF02056; maltose-6'-phosphate glucosidase complement(3887836..3889158) Escherichia coli HS 5595083 YP_001460479.1 CDS EcHS_A3894 NC_009800.1 3889158 3891035 R identified by match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR00852; match to protein family HMM TIGR02005; PTS system, alpha-glucoside-specific IIBC component complement(3889158..3891035) Escherichia coli HS 5595084 YP_001460480.1 CDS EcHS_A3895 NC_009800.1 3891070 3891786 D identified by match to protein family HMM PF00392; match to protein family HMM PF07702; GntR family transcriptional regulator 3891070..3891786 Escherichia coli HS 5591341 YP_001460481.1 CDS EcHS_A3896 NC_009800.1 3891783 3893444 R identified by match to protein family HMM PF02080; match to protein family HMM PF06826; match to protein family HMM TIGR01625; hypothetical protein complement(3891783..3893444) Escherichia coli HS 5591342 YP_001460482.1 CDS EcHS_A3897 NC_009800.1 3893474 3893635 D identified by glimmer; hypothetical protein 3893474..3893635 Escherichia coli HS 5591343 YP_001460483.1 CDS ibpB NC_009800.1 3893640 3894068 R 16 kDa heat shock protein B; associates with aggregated proteins, together with ibpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; ATP-independent; heat shock chaperone IbpB complement(3893640..3894068) Escherichia coli HS 5591344 YP_001460484.1 CDS ibpA NC_009800.1 3894180 3894593 R with IbpB associates with aggregated proteins to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; heat shock protein IbpA complement(3894180..3894593) Escherichia coli HS 5592374 YP_001460485.1 CDS EcHS_A3900 NC_009800.1 3894824 3895231 D yidQ; identified by match to protein family HMM PF07119; hypothetical protein 3894824..3895231 Escherichia coli HS 5592375 YP_001460486.1 CDS EcHS_A3901 NC_009800.1 3895233 3896447 R yidR; identified by similarity to GB:AAP18981.1; hypothetical protein complement(3895233..3896447) Escherichia coli HS 5592376 YP_001460487.1 CDS EcHS_A3902 NC_009800.1 3896548 3897648 D FAD/NAD(P)-binding domain; oxidoreductase 3896548..3897648 Escherichia coli HS 5592377 YP_001460488.1 CDS EcHS_A3903 NC_009800.1 3897609 3898946 R identified by match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM TIGR00881; match to protein family HMM TIGR00893; d-galactonate transporter complement(3897609..3898946) Escherichia coli HS 5591956 YP_001460489.1 CDS EcHS_A3904 NC_009800.1 3899021 3900169 R identified by match to protein family HMM PF01188; match to protein family HMM PF02746; galactonate dehydratase complement(3899021..3900169) Escherichia coli HS 5591957 YP_001460490.1 CDS EcHS_A3905 NC_009800.1 3900166 3900783 R catalyzes the formation of D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-galactonate 6-phosphate; functions in galactonate metabolism; 2-dehydro-3-deoxy-6-phosphogalactonate aldolase complement(3900166..3900783) Escherichia coli HS 5591958 YP_001460491.1 CDS dgoK NC_009800.1 3900767 3901645 R identified by match to protein family HMM PF05035; 2-dehydro-3-deoxygalactonokinase complement(3900767..3901645) Escherichia coli HS 5591959 YP_001460492.1 CDS dgoR NC_009800.1 3901642 3902331 R identified by similarity to SP:P31460; match to protein family HMM PF00392; match to protein family HMM PF07729; galactonate operon transcriptional repressor complement(3901642..3902331) Escherichia coli HS 5592107 YP_001460493.1 CDS EcHS_A3908 NC_009800.1 3902609 3903265 D hypothetical protein 3902609..3903265 Escherichia coli HS 5592108 YP_001460494.1 CDS yidA NC_009800.1 3903311 3904123 R YidA; catalyzes the dephosphorylation of erythrose 4-phosphate (preferred substrate), mannose 1-phosphate and p-nitrophenyl phosphate; hydrolyzes the alpha-D-glucose-1-phosphate but not the beta form; member of the haloacid dehalogenase-like hydrolases superfamily and Cof family of proteins; sugar phosphatase complement(3903311..3904123) Escherichia coli HS 5592109 YP_001460495.1 CDS EcHS_A3910 NC_009800.1 3904238 3904636 R yidB; identified by match to protein family HMM PF06078; hypothetical protein complement(3904238..3904636) Escherichia coli HS 5592110 YP_001460496.1 CDS EcHS_A3911 NC_009800.1 3904769 3904870 D identified by similarity to GB:AAN78514.1; hypothetical protein 3904769..3904870 Escherichia coli HS 5591868 YP_001460497.1 CDS gyrB NC_009800.1 3904876 3907290 R negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B complement(3904876..3907290) Escherichia coli HS 5591869 YP_001460498.1 CDS recF NC_009800.1 3907319 3908392 R Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F complement(3907319..3908392) Escherichia coli HS 5591870 YP_001460499.1 CDS dnaN NC_009800.1 3908392 3909492 R binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta complement(3908392..3909492) Escherichia coli HS 5591871 YP_001460500.1 CDS dnaA NC_009800.1 3909497 3910900 R binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein complement(3909497..3910900) Escherichia coli HS 5592521 YP_001460501.1 CDS rpmH NC_009800.1 3911507 3911647 D in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 3911507..3911647 Escherichia coli HS 5592522 YP_001460502.1 CDS rnpA NC_009800.1 3911664 3912023 D protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 3911664..3912023 Escherichia coli HS 5592523 YP_001460503.1 CDS EcHS_A3918 NC_009800.1 3911987 3912244 D identified by match to protein family HMM PF01809; match to protein family HMM TIGR00278; hypothetical protein 3911987..3912244 Escherichia coli HS 5592524 YP_001460504.1 CDS EcHS_A3919 NC_009800.1 3912247 3913893 D functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; inner membrane protein translocase component YidC 3912247..3913893 Escherichia coli HS 5592653 YP_001460505.1 CDS trmE NC_009800.1 3913999 3915363 D in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 3913999..3915363 Escherichia coli HS 5592654 YP_001460506.1 CDS tnaC NC_009800.1 3915606 3915680 D identified by match to protein family HMM TIGR02616; tryptophanase leader peptide 3915606..3915680 Escherichia coli HS 5592655 YP_001460507.1 CDS tnaA NC_009800.1 3915901 3917316 D tryptophan indole-lyase; catalyzes the formation of indole and pyruvate from tryptophan; tryptophanase 3915901..3917316 Escherichia coli HS 5592656 YP_001460508.1 CDS tnaB NC_009800.1 3917407 3918654 D tryptophan transporter of low affinity; tryptophan permease TnaB 3917407..3918654 Escherichia coli HS 5592582 YP_001460509.1 CDS mdtL NC_009800.1 3918787 3919962 D Confers resistance to chloramphenicol; multidrug efflux system protein MdtL 3918787..3919962 Escherichia coli HS 5592583 YP_001460510.1 CDS EcHS_A3925 NC_009800.1 3919937 3920896 D Involved in anaerobic NO protection; DNA-binding transcriptional regulator YidZ 3919937..3920896 Escherichia coli HS 5592584 YP_001460511.1 CDS EcHS_A3926 NC_009800.1 3921053 3921802 D yieE; identified by similarity to GB:AAP19005.1; hypothetical protein 3921053..3921802 Escherichia coli HS 5592585 YP_001460512.1 CDS EcHS_A3927 NC_009800.1 3921824 3922390 D yieF; identified by match to protein family HMM PF03358; NADPH-dependent FMN reductase 3921824..3922390 Escherichia coli HS 5592111 YP_001460513.1 CDS EcHS_A3928 NC_009800.1 3922444 3923781 R identified by match to protein family HMM PF00860; sulfate permease inorganic anion transporter complement(3922444..3923781) Escherichia coli HS 5592112 YP_001460514.1 CDS yieH NC_009800.1 3923948 3924613 D YieH; catalyzes the dephosphorylation of phosphoenolpyruvate, AMP and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; member of the haloacid dehalogenase-like hydrolases superfamily; 6-phosphogluconate phosphatase 3923948..3924613 Escherichia coli HS 5592113 YP_001460515.1 CDS EcHS_A3930 NC_009800.1 3924680 3925153 D might be involved in hypersensitivity to nitrofurzone; inner membrane protein 3924680..3925153 Escherichia coli HS 5592114 YP_001460516.1 CDS EcHS_A3931 NC_009800.1 3925202 3925789 D identified by similarity to SP:P31469; match to protein family HMM PF03691; hypothetical protein 3925202..3925789 Escherichia coli HS 5592143 YP_001460517.1 CDS EcHS_A3932 NC_009800.1 3925851 3926573 R identified by match to protein family HMM PF01182; 6-phosphogluconolactonase complement(3925851..3926573) Escherichia coli HS 5592144 YP_001460518.1 CDS bglH NC_009800.1 3927784 3929400 R identified by similarity to SP:P26218; match to protein family HMM PF02264; glucoside specific outer membrane porin BglH complement(3927784..3929400) Escherichia coli HS 5592146 YP_001460519.1 CDS EcHS_A3935 NC_009800.1 3929469 3930881 R identified by match to protein family HMM PF00232; 6-phospho-beta-glucosidase complement(3929469..3930881) Escherichia coli HS 5591162 YP_001460520.1 CDS bglF NC_009800.1 3930900 3932777 R phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; beta-glucoside-specific PTS system components IIABC complement(3930900..3932777) Escherichia coli HS 5591163 YP_001460521.1 CDS EcHS_A3937 NC_009800.1 3932911 3933747 R positive regulator of the beta-glucoside operon; transcriptional antiterminator; transcriptional antiterminator BglG complement(3932911..3933747) Escherichia coli HS 5591164 YP_001460522.1 CDS EcHS_A3938 NC_009800.1 3933813 3933935 D identified by glimmer; hypothetical protein 3933813..3933935 Escherichia coli HS 5591165 YP_001460523.1 CDS phoU NC_009800.1 3934033 3934758 R regulates several genes involved in high affinity phosphate uptake; under conditions of high phosphate concentrations downregulates the PHO regulon; transcriptional regulator PhoU complement(3934033..3934758) Escherichia coli HS 5592431 YP_001460524.1 CDS pstB NC_009800.1 3934773 3935546 R identified by match to protein family HMM PF00005; match to protein family HMM TIGR00972; phosphate transporter subunit complement(3934773..3935546) Escherichia coli HS 5592432 YP_001460525.1 CDS pstA NC_009800.1 3935729 3936619 R Part of the ABC transporter complex PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease subunit PtsA complement(3935729..3936619) Escherichia coli HS 5592433 YP_001460526.1 CDS pstC NC_009800.1 3936619 3937578 R part of the ATP-dependent phosphate uptake system PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease subunit PstC complement(3936619..3937578) Escherichia coli HS 5592434 YP_001460527.1 CDS pstS NC_009800.1 3937664 3938704 R identified by match to protein family HMM PF01547; match to protein family HMM TIGR00975; phosphate ABC transporter periplasmic substrate-binding protein PstS complement(3937664..3938704) Escherichia coli HS 5591202 YP_001460528.1 CDS glmS NC_009800.1 3939018 3940847 R Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase complement(3939018..3940847) Escherichia coli HS 5591203 YP_001460529.1 CDS glmU NC_009800.1 3941009 3942379 R forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase complement(3941009..3942379) Escherichia coli HS 5591204 YP_001460530.1 CDS EcHS_A3946 NC_009800.1 3942434 3942520 R identified by glimmer; hypothetical protein complement(3942434..3942520) Escherichia coli HS 5591205 YP_001460531.1 CDS atpC NC_009800.1 3942732 3943151 R part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; ATP synthase F0F1 subunit epsilon complement(3942732..3943151) Escherichia coli HS 5591040 YP_001460532.1 CDS atpD NC_009800.1 3943172 3944554 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; ATP synthase F0F1 subunit beta complement(3943172..3944554) Escherichia coli HS 5591041 YP_001460533.1 CDS atpG NC_009800.1 3944581 3945444 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; ATP synthase F0F1 subunit gamma complement(3944581..3945444) Escherichia coli HS 5591042 YP_001460534.1 CDS atpA NC_009800.1 3945495 3947036 R produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; ATP synthase F0F1 subunit alpha complement(3945495..3947036) Escherichia coli HS 5591043 YP_001460535.1 CDS atpH NC_009800.1 3947049 3947582 R Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; ATP synthase F0F1 subunit delta complement(3947049..3947582) Escherichia coli HS 5591139 YP_001460536.1 CDS atpF NC_009800.1 3947597 3948067 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; ATP synthase F0F1 subunit B complement(3947597..3948067) Escherichia coli HS 5591140 YP_001460537.1 CDS atpE NC_009800.1 3948129 3948368 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; ATP synthase F0F1 subunit C complement(3948129..3948368) Escherichia coli HS 5591141 YP_001460538.1 CDS atpB NC_009800.1 3948415 3949230 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; ATP synthase F0F1 subunit A complement(3948415..3949230) Escherichia coli HS 5591142 YP_001460539.1 CDS atpI NC_009800.1 3949239 3949619 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation; F0F1 ATP synthase subunit I complement(3949239..3949619) Escherichia coli HS 5591176 YP_001460540.1 CDS gidB NC_009800.1 3950236 3950859 R glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB complement(3950236..3950859) Escherichia coli HS 5591177 YP_001460541.1 CDS gidA NC_009800.1 3950923 3952812 R GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA complement(3950923..3952812) Escherichia coli HS 5591178 YP_001460542.1 CDS mioC NC_009800.1 3953191 3953634 R An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin complement(3953191..3953634) Escherichia coli HS 5591179 YP_001460543.1 CDS asnC NC_009800.1 3953724 3954182 R transcriptional repressor of asnA which codes for aspartate-ammonia ligase; DNA-binding transcriptional regulator AsnC complement(3953724..3954182) Escherichia coli HS 5591033 YP_001460544.1 CDS asnA NC_009800.1 3954334 3955326 D catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA 3954334..3955326 Escherichia coli HS 5591034 YP_001460545.1 CDS yieM NC_009800.1 3955331 3956782 R contains a von Willibrand factor type A domain; stimulates the ATPase activity of RavA; hypothetical protein complement(3955331..3956782) Escherichia coli HS 5591035 YP_001460546.1 CDS EcHS_A3962 NC_009800.1 3956776 3958296 R interacts with LdcI, lysine decarboxylase; may be active in late log/ early stationary phase; regulatory ATPase RavA complement(3956776..3958296) Escherichia coli HS 5591036 YP_001460547.1 CDS trkD NC_009800.1 3958495 3960363 D Responsible for the low-affinity transport of potassium into the cell; involved in potassium ion uptake under hyper-osmotic stress at a low pH; potassium transport protein Kup 3958495..3960363 Escherichia coli HS 5591129 YP_001460548.1 CDS rbsD NC_009800.1 3960530 3960949 D cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source; D-ribose pyranase 3960530..3960949 Escherichia coli HS 5591130 YP_001460549.1 CDS rbsA NC_009800.1 3960957 3962462 D with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain; D-ribose transporter ATP binding protein 3960957..3962462 Escherichia coli HS 5591131 YP_001460550.1 CDS rbsC NC_009800.1 3962467 3963432 D functions to transport ribose at high affinity; forms a complex with RbsA2C2B; ribose ABC transporter permease 3962467..3963432 Escherichia coli HS 5591132 YP_001460551.1 CDS rbsB NC_009800.1 3963463 3964347 D periplasmic substrate-binding component of the ATP-dependent ribose transport system; D-ribose transporter subunit RbsB 3963463..3964347 Escherichia coli HS 5591158 YP_001460552.1 CDS rbsK NC_009800.1 3964473 3965402 D catalyzes the formation of D-ribose 5-phosphate from ribose; ribokinase 3964473..3965402 Escherichia coli HS 5591159 YP_001460553.1 CDS EcHS_A3970 NC_009800.1 3966118 3966930 R identified by similarity to GB:AAP17067.1; match to protein family HMM PF00665; ISEhe3, transposase orfB complement(3966118..3966930) Escherichia coli HS 5591161 YP_001460554.1 CDS EcHS_A3971 NC_009800.1 3966987 3967265 R identified by match to protein family HMM PF01527; ISEhe3, transposase orfA complement(3966987..3967265) Escherichia coli HS 5590958 YP_001460555.1 CDS EcHS_A3973 NC_009800.1 3967596 3969023 R identified by match to protein family HMM PF07690; match to protein family HMM TIGR00711; DHA2 family drug:H+ antiporter-1 complement(3967596..3969023) Escherichia coli HS 5590960 YP_001460556.1 CDS EcHS_A3974 NC_009800.1 3969046 3969738 R yieP; identified by match to protein family HMM PF00392; match to protein family HMM PF07729; GntR family transcriptional regulator complement(3969046..3969738) Escherichia coli HS 5590961 YP_001460557.1 CDS hdfR NC_009800.1 3975539 3976378 R Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon; transcriptional regulator HdfR complement(3975539..3976378) Escherichia coli HS 5591050 YP_001460558.1 CDS EcHS_A3982 NC_009800.1 3976497 3976835 D yifE; identified by similarity to GB:AAZ90461.1; match to protein family HMM PF04219; hypothetical protein 3976497..3976835 Escherichia coli HS 5591051 YP_001460559.1 CDS EcHS_A3983 NC_009800.1 3976860 3978380 R among the AAA+ ATPases, the YifB protease belongs to the Helix 2 insert clade; unknown function; ATP-dependent protease complement(3976860..3978380) Escherichia coli HS 5591166 YP_001460560.1 CDS ilvL NC_009800.1 3978733 3978831 D identified by match to protein family HMM PF08046; ilvG operon leader peptide 3978733..3978831 Escherichia coli HS 5591167 YP_001460561.1 CDS ilvG NC_009800.1 3978971 3980617 D catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; acetolactate synthase 2 catalytic subunit 3978971..3980617 Escherichia coli HS 5591168 YP_001460562.1 CDS ilvM NC_009800.1 3980614 3980877 D identified by similarity to SP:P0ADG3; acetolactate synthase 2 regulatory subunit 3980614..3980877 Escherichia coli HS 5591169 YP_001460563.1 CDS ilvE NC_009800.1 3980897 3981826 D catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 3980897..3981826 Escherichia coli HS 5591058 YP_001460564.1 CDS ilvD NC_009800.1 3981891 3983741 D catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 3981891..3983741 Escherichia coli HS 5591059 YP_001460565.1 CDS ilvA NC_009800.1 3983744 3985288 D threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway; threonine dehydratase 3983744..3985288 Escherichia coli HS 5591060 YP_001460566.1 CDS ilvY NC_009800.1 3985340 3986233 R participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate; DNA-binding transcriptional regulator IlvY complement(3985340..3986233) Escherichia coli HS 5591061 YP_001460567.1 CDS ilvC NC_009800.1 3986383 3987858 D catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 3986383..3987858 Escherichia coli HS 5590896 YP_001460568.1 CDS ppiC NC_009800.1 3987945 3988226 R identified by match to protein family HMM PF00639; peptidyl-prolyl cis-trans isomerase C complement(3987945..3988226) Escherichia coli HS 5590897 YP_001460569.1 CDS rep NC_009800.1 3989090 3991111 D single-stranded DNA-dependent ATPase; initiates unwinding at a nick in the DNA; involved in DNA replication; ATP-dependent DNA helicase Rep 3989090..3991111 Escherichia coli HS 5590899 YP_001460570.1 CDS gppA NC_009800.1 3991158 3992642 R catalyzes the conversion of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) to guanosine 5'-diphosphate,3'-diphosphate (ppGpp); pppGpp and ppGpp control the stringent response during amino acid starvation; guanosine pentaphosphate phosphohydrolase complement(3991158..3992642) Escherichia coli HS 5590925 YP_001460571.1 CDS rhlB NC_009800.1 3992778 3994043 R enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation; ATP-dependent RNA helicase RhlB complement(3992778..3994043) Escherichia coli HS 5590926 YP_001460572.1 CDS trxA NC_009800.1 3994174 3994503 D identified by similarity to SP:P0AA25; match to protein family HMM PF00085; match to protein family HMM TIGR01068; thioredoxin 3994174..3994503 Escherichia coli HS 5590927 YP_001460573.1 CDS EcHS_A3998 NC_009800.1 3994644 3994745 D identified by glimmer; rho operon leader peptide 3994644..3994745 Escherichia coli HS 5590928 YP_001460574.1 CDS rho NC_009800.1 3994830 3996089 D An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 3994830..3996089 Escherichia coli HS 5590938 YP_001460575.1 CDS EcHS_A4000 NC_009800.1 3996099 3996317 D identified by glimmer; hypothetical protein 3996099..3996317 Escherichia coli HS 5590939 YP_001460576.1 CDS wecA NC_009800.1 3996329 3997432 D identified by match to protein family HMM PF00953; match to protein family HMM TIGR02380; undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase 3996329..3997432 Escherichia coli HS 5590940 YP_001460577.1 CDS EcHS_A4002 NC_009800.1 3997444 3998490 D Enterobacterial Common Antigen (ECA) polysaccharide chain length modulation protein; lipopolysaccharide biosynthesis protein WzzE 3997444..3998490 Escherichia coli HS 5590941 YP_001460578.1 CDS EcHS_A4003 NC_009800.1 3998546 3999676 D identified by match to protein family HMM PF02350; match to protein family HMM TIGR00236; UDP-N-acetylglucosamine 2-epimerase 3998546..3999676 Escherichia coli HS 5592285 YP_001460579.1 CDS wecC NC_009800.1 3999673 4000935 D catalyzes the oxidation of UDP-N-acetyl-D-mannosamine to UDP-N-acetylmannosaminuronic acid; UDP-N-acetyl-D-mannosamine dehydrogenase 3999673..4000935 Escherichia coli HS 5592286 YP_001460580.1 CDS rfbB2 NC_009800.1 4000935 4002002 D identified by similarity to SP:P27830; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993; match to protein family HMM TIGR01181; dTDP-glucose 4,6-dehydratase 4000935..4002002 Escherichia coli HS 5592287 YP_001460581.1 CDS rfbA1 NC_009800.1 4002021 4002902 D identified by match to protein family HMM PF00483; match to protein family HMM TIGR01207; glucose-1-phosphate thymidylyltransferase 4002021..4002902 Escherichia coli HS 5592288 YP_001460582.1 CDS wecD NC_009800.1 4003009 4003554 D wecD; identified by match to protein family HMM PF00583; match to protein family HMM TIGR02382; TDP-fucosamine acetyltransferase 4003009..4003554 Escherichia coli HS 5592219 YP_001460583.1 CDS wecE NC_009800.1 4003559 4004689 D catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis; TDP-4-oxo-6-deoxy-D-glucose transaminase 4003559..4004689 Escherichia coli HS 5592220 YP_001460584.1 CDS EcHS_A4009 NC_009800.1 4004691 4005941 D polysaccharide biosynthesis protein 4004691..4005941 Escherichia coli HS 5592221 YP_001460585.1 CDS wecF NC_009800.1 4005938 4007017 D catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis; 4-alpha-L-fucosyltransferase 4005938..4007017 Escherichia coli HS 5592222 YP_001460586.1 CDS wzyE NC_009800.1 4007014 4008366 D enterobacterial common antigen polymerase; common antigen polymerase 4007014..4008366 Escherichia coli HS 5591830 YP_001460587.1 CDS EcHS_A4012 NC_009800.1 4008369 4009109 D identified by match to protein family HMM PF03808; match to protein family HMM TIGR00696; UDP-N-acetyl-D-mannosaminuronic acid transferase 4008369..4009109 Escherichia coli HS 5591831 YP_001460588.1 CDS EcHS_A4013 NC_009800.1 4009180 4009278 R identified by glimmer; hypothetical protein complement(4009180..4009278) Escherichia coli HS 5591832 YP_001460589.1 CDS EcHS_A4014 NC_009800.1 4009300 4010685 D uncharacterized member of the amino acid-polyamine-organocation (APC) superfamily of amino acid transporters; unknown function; transport protein YifK 4009300..4010685 Escherichia coli HS 5591833 YP_001460590.1 CDS aslB NC_009800.1 4011371 4012606 D identified by similarity to SP:P25550; match to protein family HMM PF04055; arylsulfatase 4011371..4012606 Escherichia coli HS 5591734 YP_001460591.1 CDS EcHS_A4020 NC_009800.1 4012690 4012851 R identified by similarity to SP:P25549; arylsulfatase complement(4012690..4012851) Escherichia coli HS 5591735 YP_001460592.1 CDS EcHS_A4021 NC_009800.1 4012994 4013131 R identified by glimmer; hypothetical protein complement(4012994..4013131) Escherichia coli HS 5591226 YP_001460593.1 CDS hemY NC_009800.1 4013530 4014726 R identified by match to protein family HMM PF07219; match to protein family HMM PF07719; match to protein family HMM TIGR00540; protoheme IX biogenesis protein complement(4013530..4014726) Escherichia coli HS 5591228 YP_001460594.1 CDS EcHS_A4023 NC_009800.1 4014729 4015904 R identified by match to protein family HMM PF04375; uroporphyrinogen III C-methyltransferase complement(4014729..4015904) Escherichia coli HS 5592073 YP_001460595.1 CDS hemD NC_009800.1 4015926 4016666 R catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis; uroporphyrinogen-III synthase complement(4015926..4016666) Escherichia coli HS 5592074 YP_001460596.1 CDS hemC NC_009800.1 4016663 4017625 R transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase complement(4016663..4017625) Escherichia coli HS 5592075 YP_001460597.1 CDS cyaA NC_009800.1 4017991 4020537 D catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP; adenylate cyclase 4017991..4020537 Escherichia coli HS 5592076 YP_001460598.1 CDS cyaY NC_009800.1 4020577 4020897 R defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly; frataxin-like protein complement(4020577..4020897) Escherichia coli HS 5591741 YP_001460599.1 CDS EcHS_A4029 NC_009800.1 4020945 4022270 R hypothetical protein complement(4020945..4022270) Escherichia coli HS 5591742 YP_001460600.1 CDS EcHS_A4030 NC_009800.1 4022267 4023736 R lipoprotein complement(4022267..4023736) Escherichia coli HS 5591743 YP_001460601.1 CDS EcHS_A4031 NC_009800.1 4023824 4023937 R identified by glimmer; hypothetical protein complement(4023824..4023937) Escherichia coli HS 5591744 YP_001460602.1 CDS EcHS_A4032 NC_009800.1 4024102 4024656 R hypothetical protein complement(4024102..4024656) Escherichia coli HS 5591754 YP_001460603.1 CDS EcHS_A4033 NC_009800.1 4024999 4025202 D lipoprotein 4024999..4025202 Escherichia coli HS 5591755 YP_001460604.1 CDS dapF NC_009800.1 4025239 4026063 D involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 4025239..4026063 Escherichia coli HS 5591756 YP_001460605.1 CDS EcHS_A4035 NC_009800.1 4026060 4026767 D identified by similarity to SP:P23305; match to protein family HMM PF04340; hypothetical protein 4026060..4026767 Escherichia coli HS 5591757 YP_001460606.1 CDS xerC NC_009800.1 4026764 4027660 D site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC 4026764..4027660 Escherichia coli HS 5591841 YP_001460607.1 CDS EcHS_A4037 NC_009800.1 4027660 4028376 D YigB; member of the haloacid dehalogenase (HAD)-like hydrolases superfamily of protein; unknown function; flavin mononucleotide phosphatase 4027660..4028376 Escherichia coli HS 5591842 YP_001460608.1 CDS uvrD NC_009800.1 4028460 4030622 D unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair.; DNA-dependent helicase II 4028460..4030622 Escherichia coli HS 5591843 YP_001460609.1 CDS EcHS_A4040 NC_009800.1 4030769 4031533 R yigE; hypothetical protein complement(4030769..4031533) Escherichia coli HS 5591844 YP_001460610.1 CDS EcHS_A4039 NC_009800.1 4031525 4031659 D identified by glimmer; hypothetical protein 4031525..4031659 Escherichia coli HS 5593300 YP_001460611.1 CDS corA NC_009800.1 4031903 4032853 D responsible for the influx of magnesium ions; magnesium/nickel/cobalt transporter CorA 4031903..4032853 Escherichia coli HS 5593301 YP_001460612.1 CDS EcHS_A4042 NC_009800.1 4032896 4033276 R yigF; hypothetical protein complement(4032896..4033276) Escherichia coli HS 5593302 YP_001460613.1 CDS rarD NC_009800.1 4033765 4034655 R rarD; identified by match to protein family HMM PF00892; match to protein family HMM TIGR00688; RarD protein complement(4033765..4034655) Escherichia coli HS 5593303 YP_001460614.1 CDS EcHS_A4044 NC_009800.1 4034707 4035192 R yigI; identified by match to protein family HMM PF03061; match to protein family HMM TIGR00369; hypothetical protein complement(4034707..4035192) Escherichia coli HS 5593225 YP_001460615.1 CDS pldA NC_009800.1 4035339 4036208 D catalyzes the hydrolysis of phosphatidylcholine; phospholipase A 4035339..4036208 Escherichia coli HS 5593226 YP_001460616.1 CDS recQ NC_009800.1 4036341 4038170 D functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway; ATP-dependent DNA helicase RecQ 4036341..4038170 Escherichia coli HS 5593227 YP_001460617.1 CDS rhtC NC_009800.1 4038240 4038854 D identified by match to protein family HMM PF01810; match to protein family HMM TIGR00949; threonine efflux system 4038240..4038854 Escherichia coli HS 5593228 YP_001460618.1 CDS rhtB NC_009800.1 4038916 4039536 R identified by match to protein family HMM PF01810; match to protein family HMM TIGR00949; homoserine/homoserine lactone efflux protein complement(4038916..4039536) Escherichia coli HS 5595349 YP_001460619.1 CDS pldB NC_009800.1 4039647 4040669 D lecithinase B; catalyzes the conversion of 1-lysophosphatidylcholine to glycerophosphocholine; can also hydrolyze 2-acyl glycerophosphoethanolamine and other substrates; lysophospholipase L2 4039647..4040669 Escherichia coli HS 5595350 YP_001460620.1 CDS EcHS_A4050 NC_009800.1 4040677 4041477 D purine and pyrimidine nucleotides are secondary substrates; yigL expression is regulated by heat shock, osmotic shock and starvation of glucose, phosphate or ammonium; sugar phosphatase 4040677..4041477 Escherichia coli HS 5595351 YP_001460621.1 CDS EcHS_A4051 NC_009800.1 4041553 4042452 D yigM; identified by match to protein family HMM PF00892; match to protein family HMM TIGR00950; 10 TMS drug/metabolite exporter (DME) family protein 4041553..4042452 Escherichia coli HS 5595352 YP_001460622.1 CDS metR NC_009800.1 4042340 4043293 R identified by similarity to SP:P0A9F9; match to protein family HMM PF00126; match to protein family HMM PF03466; transcriptional regulator MetR complement(4042340..4043293) Escherichia coli HS 5591106 YP_001460623.1 CDS metE NC_009800.1 4043411 4045672 D catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 4043411..4045672 Escherichia coli HS 5591107 YP_001460624.1 CDS EcHS_A4054 NC_009800.1 4045712 4046527 R identified by match to protein family HMM PF01738; dienelactone hydrolase complement(4045712..4046527) Escherichia coli HS 5591108 YP_001460625.1 CDS udp NC_009800.1 4046789 4047550 D catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway; uridine phosphorylase 4046789..4047550 Escherichia coli HS 5591109 YP_001460626.1 CDS rmuC NC_009800.1 4047691 4049118 D YigN; nuclease that may cleave DNA structures arising during the recombination of short-inverted repeats and thereby prevents the inversion of the internal sequence; transcription is induced by DNA-damaging agents such as nalidixic acid or mitomycin C in a LexA-dependent manner; DNA recombination protein RmuC 4047691..4049118 Escherichia coli HS 5592438 YP_001460627.1 CDS ubiE NC_009800.1 4049213 4049968 D Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase 4049213..4049968 Escherichia coli HS 5592439 YP_001460628.1 CDS EcHS_A4058 NC_009800.1 4049982 4050587 D yigP; identified by match to protein family HMM PF06843; hypothetical protein 4049982..4050587 Escherichia coli HS 5592440 YP_001460629.1 CDS ubiB NC_009800.1 4050584 4052224 D an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions; ubiquinone biosynthesis protein UbiB 4050584..4052224 Escherichia coli HS 5592441 YP_001460630.1 CDS tatA NC_009800.1 4052303 4052572 D TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase A 4052303..4052572 Escherichia coli HS 5592675 YP_001460631.1 CDS tatB NC_009800.1 4052576 4053091 D mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase 4052576..4053091 Escherichia coli HS 5592676 YP_001460632.1 CDS tatC NC_009800.1 4053094 4053870 D with TatABE forms the twin-arginine translocation complex which is involved in the transport of proteins across the cytoplasmic membrane; twin-arginine protein translocation system subunit TatC 4053094..4053870 Escherichia coli HS 5592677 YP_001460633.1 CDS tatD NC_009800.1 4053912 4054694 D magnesium dependent; not involved in the Sec-independent protein export system; DNase TatD 4053912..4054694 Escherichia coli HS 5592678 YP_001460634.1 CDS rfaH NC_009800.1 4054691 4055179 R identified by similarity to SP:P26614; match to protein family HMM PF02357; match to protein family HMM TIGR01955; transcriptional activator RfaH complement(4054691..4055179) Escherichia coli HS 5594372 YP_001460635.1 CDS ubiD NC_009800.1 4055346 4056839 D catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 4055346..4056839 Escherichia coli HS 5594373 YP_001460636.1 CDS fre NC_009800.1 4056885 4057586 D NAD(P)H-flavin reductase; catalyzes the reversible oxidation/reduction of NAD(P) and flavine mononucleotide; in Salmonella and E. coli this protein also reduces aquacob(III)alamin to cob(II)alamin; FMN reductase 4056885..4057586 Escherichia coli HS 5594374 YP_001460637.1 CDS fadA NC_009800.1 4057869 4059032 R FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; 3-ketoacyl-CoA thiolase complement(4057869..4059032) Escherichia coli HS 5595360 YP_001460638.1 CDS fadB NC_009800.1 4059042 4061231 R includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; multifunctional fatty acid oxidation complex subunit alpha complement(4059042..4061231) Escherichia coli HS 5595361 YP_001460639.1 CDS pepQ NC_009800.1 4061421 4062752 D catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters; proline dipeptidase 4061421..4062752 Escherichia coli HS 5595362 YP_001460640.1 CDS EcHS_A4071 NC_009800.1 4062749 4063366 D yigZ; identified by match to protein family HMM PF01205; match to protein family HMM PF09186; match to protein family HMM TIGR00257; hypothetical protein 4062749..4063366 Escherichia coli HS 5595363 YP_001460641.1 CDS trkH NC_009800.1 4063405 4064856 D identified by match to protein family HMM PF02386; match to protein family HMM TIGR00933; potassium transporter 4063405..4064856 Escherichia coli HS 5594754 YP_001460642.1 CDS hemG NC_009800.1 4064868 4065413 D catalyzes the oxidation of protoporphyrinogen IX to form protoporphyrin IX; protoporphyrinogen oxidase 4064868..4065413 Escherichia coli HS 5594755 YP_001460643.1 CDS mobB NC_009800.1 4071086 4071613 R identified by match to protein family HMM PF03205; match to protein family HMM TIGR00176; molybdopterin-guanine dinucleotide biosynthesis protein B complement(4071086..4071613) Escherichia coli HS 5591620 YP_001460644.1 CDS mobA NC_009800.1 4071595 4072179 R Links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis; molybdopterin-guanine dinucleotide biosynthesis protein A complement(4071595..4072179) Escherichia coli HS 5591103 YP_001460645.1 CDS EcHS_A4081 NC_009800.1 4072249 4072518 D yihD; identified by match to protein family HMM PF06288; hypothetical protein 4072249..4072518 Escherichia coli HS 5591104 YP_001460646.1 CDS EcHS_A4082 NC_009800.1 4072595 4073581 D catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages; serine/threonine protein kinase 4072595..4073581 Escherichia coli HS 5591105 YP_001460647.1 CDS dsbA NC_009800.1 4073598 4074224 D identified by similarity to SP:P52235; match to protein family HMM PF01323; periplasmic protein disulfide isomerase I 4073598..4074224 Escherichia coli HS 5591486 YP_001460648.1 CDS EcHS_A4084 NC_009800.1 4074249 4074389 D identified by glimmer; hypothetical protein 4074249..4074389 Escherichia coli HS 5591487 YP_001460649.1 CDS EcHS_A4085 NC_009800.1 4074379 4075809 D yihF; identified by match to protein family HMM PF06097; hypothetical protein 4074379..4075809 Escherichia coli HS 5591488 YP_001460650.1 CDS EcHS_A4086 NC_009800.1 4075850 4076755 R identified by match to protein family HMM PF01553; acyltransferase complement(4075850..4076755) Escherichia coli HS 5591489 YP_001460651.1 CDS EcHS_A4087 NC_009800.1 4076902 4077144 R identified by glimmer; hypothetical protein complement(4076902..4077144) Escherichia coli HS 5591455 YP_001460652.1 CDS polA NC_009800.1 4077146 4079932 D has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 4077146..4079932 Escherichia coli HS 5591456 YP_001460653.1 CDS engB NC_009800.1 4080314 4080946 R binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC complement(4080314..4080946) Escherichia coli HS 5591458 YP_001460654.1 CDS EcHS_A4091 NC_009800.1 4081528 4082034 D identified by similarity to SP:Q8X8G9; match to protein family HMM PF04220; hypothetical protein 4081528..4082034 Escherichia coli HS 5593168 YP_001460655.1 CDS hemN NC_009800.1 4082223 4083596 D catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 4082223..4083596 Escherichia coli HS 5593723 YP_001460656.1 CDS EcHS_A4093 NC_009800.1 4083689 4083802 R identified by glimmer; hypothetical protein complement(4083689..4083802) Escherichia coli HS 5593724 YP_001460657.1 CDS EcHS_A4094 NC_009800.1 4083786 4083896 R identified by glimmer; hypothetical protein complement(4083786..4083896) Escherichia coli HS 5593725 YP_001460658.1 CDS glnG NC_009800.1 4084008 4085417 R response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes; interacts with sigma-54; nitrogen regulation protein NR(I) complement(4084008..4085417) Escherichia coli HS 5593726 YP_001460659.1 CDS glnL NC_009800.1 4085429 4086478 R sensory histidine kinase in two-component regulatory system with GlnG; acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC by phosphorylation/dephosphorylation; nitrogen regulation protein NR(II) complement(4085429..4086478) Escherichia coli HS 5592923 YP_001460660.1 CDS glnA NC_009800.1 4086764 4088173 R forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme; glutamine synthetase complement(4086764..4088173) Escherichia coli HS 5592924 YP_001460661.1 CDS typA NC_009800.1 4088546 4090369 D identified by match to protein family HMM PF00009; match to protein family HMM PF00679; match to protein family HMM PF03144; match to protein family HMM TIGR00231; match to protein family HMM TIGR01394; GTP-binding protein 4088546..4090369 Escherichia coli HS 5592925 YP_001460662.1 CDS EcHS_A4099 NC_009800.1 4090586 4091296 D identified by match to protein family HMM PF00392; match to protein family HMM PF07702; GntR family transcriptional regulator 4090586..4091296 Escherichia coli HS 5592926 YP_001460663.1 CDS EcHS_A4100 NC_009800.1 4091304 4092284 D identified by match to protein family HMM PF01261; AP endonuclease 4091304..4092284 Escherichia coli HS 5592770 YP_001460664.1 CDS EcHS_A4101 NC_009800.1 4092386 4093651 D identified by match to protein family HMM PF07690; major facilitator transporter 4092386..4093651 Escherichia coli HS 5592771 YP_001460665.1 CDS EcHS_A4102 NC_009800.1 4093762 4094550 R identified by match to protein family HMM PF00392; match to protein family HMM PF00455; match to protein family HMM PF08220; match to protein family HMM PF08279; DeoR family transcriptional regulator complement(4093762..4094550) Escherichia coli HS 5592772 YP_001460666.1 CDS EcHS_A4103 NC_009800.1 4094590 4095486 R identified by match to protein family HMM PF00294; PfkB family kinase complement(4094590..4095486) Escherichia coli HS 5592773 YP_001460667.1 CDS EcHS_A4104 NC_009800.1 4095659 4096537 D identified by match to protein family HMM PF03446; 3-hydroxyisobutyrate dehydrogenase 4095659..4096537 Escherichia coli HS 5592949 YP_001460668.1 CDS EcHS_A4105 NC_009800.1 4096562 4097449 D identified by match to protein family HMM PF01791; deoxyribose-phosphate aldolase 4096562..4097449 Escherichia coli HS 5592950 YP_001460669.1 CDS EcHS_A4106 NC_009800.1 4097482 4098492 D identified by match to protein family HMM PF00107; match to protein family HMM PF08240; zinc-binding dehydrogenase oxidoreductase 4097482..4098492 Escherichia coli HS 5592951 YP_001460670.1 CDS EcHS_A4107 NC_009800.1 4098562 4099995 D identified by match to protein family HMM PF00083; match to protein family HMM PF07690; major facilitator transporter 4098562..4099995 Escherichia coli HS 5592952 YP_001460671.1 CDS EcHS_A4108 NC_009800.1 4100094 4101443 D identified by match to protein family HMM PF00083; match to protein family HMM PF07690; major facilitator family transporter 4100094..4101443 Escherichia coli HS 5591406 YP_001460672.1 CDS EcHS_A4109 NC_009800.1 4101433 4102320 D identified by match to protein family HMM PF01263; aldose 1-epimerase 4101433..4102320 Escherichia coli HS 5591407 YP_001460673.1 CDS yihX NC_009800.1 4102461 4103060 D identified by similarity to SP:P0A8Y4; match to protein family HMM PF00702; match to protein family HMM TIGR01509; phosphatase 4102461..4103060 Escherichia coli HS 5591408 YP_001460674.1 CDS rbn NC_009800.1 4103054 4103926 D RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease; ribonuclease BN 4103054..4103926 Escherichia coli HS 5591409 YP_001460675.1 CDS dtd NC_009800.1 4103923 4104360 D hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 4103923..4104360 Escherichia coli HS 5591996 YP_001460676.1 CDS EcHS_A4113 NC_009800.1 4104405 4105346 D identified by match to protein family HMM PF00583; match to protein family HMM TIGR02447; acetyltransferase 4104405..4105346 Escherichia coli HS 5591997 YP_001460677.1 CDS EcHS_A4114 NC_009800.1 4105917 4106021 R identified by glimmer; hypothetical protein complement(4105917..4106021) Escherichia coli HS 5591998 YP_001460678.1 CDS EcHS_A4115 NC_009800.1 4106172 4106417 D identified by match to protein family HMM PF01402; CopG family protein 4106172..4106417 Escherichia coli HS 5591999 YP_001460679.1 CDS EcHS_A4117 NC_009800.1 4106635 4106877 D yiiF; hypothetical protein 4106635..4106877 Escherichia coli HS 5593074 YP_001460680.1 CDS EcHS_A4118 NC_009800.1 4107106 4108086 R identified by match to protein family HMM PF01548; match to protein family HMM PF02371; IS621, transposase complement(4107106..4108086) Escherichia coli HS 5593075 YP_001460681.1 CDS fdhE NC_009800.1 4108486 4109415 R required for the formation of active formate dehydrogenase; formate dehydrogenase accessory protein FdhE complement(4108486..4109415) Escherichia coli HS 5593076 YP_001460682.1 CDS fdoI NC_009800.1 4109412 4110047 R cytochrome b556(FDO) component; heme containing; formate dehydrogenase-O subunit gamma complement(4109412..4110047) Escherichia coli HS 5593077 YP_001460683.1 CDS fdoH NC_009800.1 4110044 4110946 R identified by similarity to SP:P0AAJ5; match to protein family HMM PF00037; match to protein family HMM PF09163; match to protein family HMM TIGR01582; formate dehydrogenase-O, iron-sulfur subunit complement(4110044..4110946) Escherichia coli HS 5594560 YP_001460684.1 CDS fdoG NC_009800.1 4110959 4114009 R Selenoprotein. identified by similarity to SP:P32176; match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM PF04879; match to protein family HMM TIGR01409; match to protein family HMM TIGR01553; formate dehydrogenase-O, major subunit, selenocysteine-containing complement(4110959..4114009) Escherichia coli HS 5594561 YP_001460685.1 CDS fdhD NC_009800.1 4114236 4115036 D involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth; formate dehydrogenase accessory protein 4114236..4115036 Escherichia coli HS 5594562 YP_001460686.1 CDS EcHS_A4124 NC_009800.1 4115189 4116244 D yiiG; lipoprotein 4115189..4116244 Escherichia coli HS 5594563 YP_001460687.1 CDS EcHS_A4125 NC_009800.1 4116294 4118048 R repressor of the frv operon, involved in phosphoenolpyruvate:sugar phosphotransferase system; frv operon regulatory protein complement(4116294..4118048) Escherichia coli HS 5593412 YP_001460688.1 CDS EcHS_A4126 NC_009800.1 4118048 4119118 R with FrvABR is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system which may be involved in the transport and phosphorylation of sugars; fructose-specific phosphotransferase system protein FrvX complement(4118048..4119118) Escherichia coli HS 5593413 YP_001460689.1 CDS EcHS_A4127 NC_009800.1 4119108 4120559 R identified by similarity to SP:P32154; match to protein family HMM PF02378; match to protein family HMM PF02379; match to protein family HMM TIGR00829; match to protein family HMM TIGR01427; PTS transporter components IIBC complement(4119108..4120559) Escherichia coli HS 5593414 YP_001460690.1 CDS EcHS_A4128 NC_009800.1 4120570 4121016 R with FrvBRX is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system involved in the transport and phosphorylation of sugars; possibly responsible for the sugar specificity of the system; fructose-like phosphotransferase system subunit EIIA complement(4120570..4121016) Escherichia coli HS 5593415 YP_001460691.1 CDS rhaU NC_009800.1 4121317 4121631 R yiiL; identified by match to protein family HMM PF05336; match to protein family HMM TIGR02625; L-rhamnose 1-epimerase complement(4121317..4121631) Escherichia coli HS 5592693 YP_001460692.1 CDS rhaD NC_009800.1 4121641 4122465 R identified by similarity to SP:P32169; match to protein family HMM PF00596; match to protein family HMM TIGR02624; rhamnulose-1-phosphate aldolase complement(4121641..4122465) Escherichia coli HS 5592694 YP_001460693.1 CDS rhaA NC_009800.1 4122732 4123991 R catalyzes the formation of L-rhamnulose from L-rhamnose; L-rhamnose isomerase complement(4122732..4123991) Escherichia coli HS 5592695 YP_001460694.1 CDS rhaB NC_009800.1 4123988 4125457 R catalyzes the ATP-dependent phosphorylation of rhamnulose; rhamnulokinase complement(4123988..4125457) Escherichia coli HS 5592696 YP_001460695.1 CDS EcHS_A4134 NC_009800.1 4125536 4125685 D identified by glimmer; hypothetical protein 4125536..4125685 Escherichia coli HS 5591245 YP_001460696.1 CDS rhaS NC_009800.1 4125745 4126581 D activates the expression of the rhaBAD operon and rhaT gene; transcriptional activator RhaS 4125745..4126581 Escherichia coli HS 5591246 YP_001460697.1 CDS rhaR NC_009800.1 4126565 4127503 D activates the expression of rhaRS in response to L-rhamnose; transcriptional activator RhaR 4126565..4127503 Escherichia coli HS 5591247 YP_001460698.1 CDS rhaT NC_009800.1 4127500 4128534 R transports L-rhamnose and L-lyxose into the cell; rhamnose-proton symporter complement(4127500..4128534) Escherichia coli HS 5591248 YP_001460699.1 CDS sodA NC_009800.1 4128819 4129439 D SodA; manganese binding; only present under aerobic conditions; destroys free radicals; superoxide dismutase 4128819..4129439 Escherichia coli HS 5591191 YP_001460700.1 CDS EcHS_A4139 NC_009800.1 4129480 4129596 R hypothetical protein complement(4129480..4129596) Escherichia coli HS 5591192 YP_001460701.1 CDS kdgT NC_009800.1 4129699 4130682 D transports degraded pectin products into the bacterial cell; 2-keto-3-deoxygluconate permease 4129699..4130682 Escherichia coli HS 5591193 YP_001460702.1 CDS EcHS_A4141 NC_009800.1 4130831 4131505 D yiiM; identified by match to protein family HMM PF03473; match to protein family HMM PF03475; hypothetical protein 4130831..4131505 Escherichia coli HS 5591194 YP_001460703.1 CDS cpxA NC_009800.1 4131611 4132984 R part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors; two-component sensor protein complement(4131611..4132984) Escherichia coli HS 5591557 YP_001460704.1 CDS cpxR NC_009800.1 4132981 4133679 R response regulator in two-component regulatory system with CpxA; part of the envelope stress response system; DNA-binding transcriptional regulator CpxR complement(4132981..4133679) Escherichia coli HS 5591558 YP_001460705.1 CDS cpxP NC_009800.1 4133829 4134329 D repressor of the Cpx envelope stress response pathway which occurs via periplasmic interactions with CpxA; CpxP is degraded by DegP protease especially in the presence of misfolded substrates; periplasmic repressor CpxP 4133829..4134329 Escherichia coli HS 5591559 YP_001460706.1 CDS fieF NC_009800.1 4134478 4135380 D member of cation diffusion facilitator family; CDF; membrane-bound; induced by both zinc and iron, but does not induce resistance to zinc; can transport zinc(II) in a proton-dependent manner; instead this protein induces iron resistance; forms dimers; ferrous iron efflux protein F 4134478..4135380 Escherichia coli HS 5591560 YP_001460707.1 CDS pfkA NC_009800.1 4135561 4136523 D catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 4135561..4136523 Escherichia coli HS 5591649 YP_001460708.1 CDS EcHS_A4147 NC_009800.1 4136563 4136760 D identified by similarity to GB:ABB67500.1; hypothetical protein 4136563..4136760 Escherichia coli HS 5591650 YP_001460709.1 CDS sbp NC_009800.1 4136843 4137832 D identified by match to protein family HMM PF01547; match to protein family HMM TIGR00971; sulfate transporter subunit 4136843..4137832 Escherichia coli HS 5591651 YP_001460710.1 CDS cdh NC_009800.1 4137939 4138694 D identified by similarity to SP:P06282; match to protein family HMM PF02611; match to protein family HMM TIGR00672; CDP-diacylglycerol pyrophosphatase 4137939..4138694 Escherichia coli HS 5591652 YP_001460711.1 CDS tpiA NC_009800.1 4138749 4139516 R Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase complement(4138749..4139516) Escherichia coli HS 5591606 YP_001460712.1 CDS EcHS_A4151 NC_009800.1 4139624 4140223 R yiiQ; identified by match to protein family HMM PF07305; hypothetical protein complement(4139624..4140223) Escherichia coli HS 5591607 YP_001460713.1 CDS EcHS_A4152 NC_009800.1 4140324 4140764 D yiiR; identified by match to protein family HMM PF05656; hypothetical protein 4140324..4140764 Escherichia coli HS 5591608 YP_001460714.1 CDS EcHS_A4153 NC_009800.1 4140976 4141275 D yiiS; identified by match to protein family HMM PF04175; match to protein family HMM TIGR00743; hypothetical protein 4140976..4141275 Escherichia coli HS 5591609 YP_001460715.1 CDS uspD NC_009800.1 4141302 4141730 D with UspC and Usp E is involved in resistance to UV radiation; universal stress protein UspD 4141302..4141730 Escherichia coli HS 5591718 YP_001460716.1 CDS fpr NC_009800.1 4141735 4142481 R identified by similarity to SP:P28861; match to protein family HMM PF00175; match to protein family HMM PF00970; ferredoxin-NADP reductase complement(4141735..4142481) Escherichia coli HS 5591719 YP_001460717.1 CDS glpX NC_009800.1 4142578 4143588 R type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II complement(4142578..4143588) Escherichia coli HS 5591720 YP_001460718.1 CDS glpK NC_009800.1 4143723 4145231 R Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase complement(4143723..4145231) Escherichia coli HS 5591721 YP_001460719.1 CDS glpF NC_009800.1 4145254 4146099 R identified by similarity to SP:P31140; match to protein family HMM PF00230; match to protein family HMM TIGR00861; glycerol uptake facilitator protein complement(4145254..4146099) Escherichia coli HS 5591706 YP_001460720.1 CDS EcHS_A4159 NC_009800.1 4146336 4146437 D identified by glimmer; hypothetical protein 4146336..4146437 Escherichia coli HS 5591707 YP_001460721.1 CDS EcHS_A4160 NC_009800.1 4146530 4146769 D yiiU; identified by match to protein family HMM PF06005; hypothetical protein 4146530..4146769 Escherichia coli HS 5591708 YP_001460722.1 CDS rraA NC_009800.1 4146854 4147339 R regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA complement(4146854..4147339) Escherichia coli HS 5591709 YP_001460723.1 CDS menA NC_009800.1 4147432 4148358 R catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase complement(4147432..4148358) Escherichia coli HS 5595024 YP_001460724.1 CDS hslU NC_009800.1 4148425 4149756 R heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU complement(4148425..4149756) Escherichia coli HS 5595025 YP_001460725.1 CDS hslV NC_009800.1 4149766 4150296 R heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit complement(4149766..4150296) Escherichia coli HS 5595026 YP_001460726.1 CDS ftsN NC_009800.1 4150389 4151348 R identified by similarity to SP:P29131; match to protein family HMM PF05036; match to protein family HMM TIGR02223; essential cell division protein FtsN complement(4150389..4151348) Escherichia coli HS 5595027 YP_001460727.1 CDS cytR NC_009800.1 4151440 4152471 R negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins; DNA-binding transcriptional regulator CytR complement(4151440..4152471) Escherichia coli HS 5591806 YP_001460728.1 CDS priA NC_009800.1 4152621 4154819 R binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA complement(4152621..4154819) Escherichia coli HS 5591807 YP_001460729.1 CDS rpmE NC_009800.1 4155022 4155234 D RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 4155022..4155234 Escherichia coli HS 5591808 YP_001460730.1 CDS EcHS_A4169 NC_009800.1 4155289 4155912 R identified by match to protein family HMM TIGR02117; lipoprotein complement(4155289..4155912) Escherichia coli HS 5591809 YP_001460731.1 CDS EcHS_A4170 NC_009800.1 4155919 4156527 R member of the NlpC/P60 superfamily of peptidases; peptidoglycan peptidase complement(4155919..4156527) Escherichia coli HS 5591645 YP_001460732.1 CDS EcHS_A4171 NC_009800.1 4156540 4156656 D identified by glimmer; hypothetical protein 4156540..4156656 Escherichia coli HS 5591646 YP_001460733.1 CDS metJ NC_009800.1 4156711 4157028 R when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis; transcriptional repressor protein MetJ complement(4156711..4157028) Escherichia coli HS 5591647 YP_001460734.1 CDS metB NC_009800.1 4157305 4158465 D catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase 4157305..4158465 Escherichia coli HS 5591648 YP_001460735.1 CDS metL NC_009800.1 4158468 4160900 D multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartate kinase II/homoserine dehydrogenase II 4158468..4160900 Escherichia coli HS 5594263 YP_001460736.1 CDS metF NC_009800.1 4161249 4162139 D MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor; 5,10-methylenetetrahydrofolate reductase 4161249..4162139 Escherichia coli HS 5594264 YP_001460737.1 CDS katG NC_009800.1 4162468 4164648 D identified by similarity to SP:P13029; match to protein family HMM PF00141; match to protein family HMM TIGR00198; catalase/peroxidase HPI 4162468..4164648 Escherichia coli HS 5594265 YP_001460738.1 CDS EcHS_A4177 NC_009800.1 4164741 4165646 D yijE; identified by similarity to SP:P0ABT8; match to protein family HMM PF00892; transporter 4164741..4165646 Escherichia coli HS 5594266 YP_001460739.1 CDS EcHS_A4178 NC_009800.1 4165673 4166290 R yijF; identified by similarity to GB:AAZ90633.1; match to protein family HMM PF06940; hypothetical protein complement(4165673..4166290) Escherichia coli HS 5594552 YP_001460740.1 CDS EcHS_A4179 NC_009800.1 4166600 4167580 R identified by match to protein family HMM PF01548; match to protein family HMM PF02371; IS621, transposase complement(4166600..4167580) Escherichia coli HS 5594553 YP_001460741.1 CDS gldA NC_009800.1 4167844 4168947 R forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; glycerol dehydrogenase complement(4167844..4168947) Escherichia coli HS 5594554 YP_001460742.1 CDS fsaB NC_009800.1 4168958 4169620 R similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase complement(4168958..4169620) Escherichia coli HS 5594555 YP_001460743.1 CDS ptsA NC_009800.1 4169632 4172133 R identified by similarity to SP:P32670; match to protein family HMM PF00359; match to protein family HMM PF00381; match to protein family HMM PF00391; match to protein family HMM PF02896; match to protein family HMM PF05524; match to protein family HMM TIGR01417; multi-phosphoryl transfer protein 2 complement(4169632..4172133) Escherichia coli HS 5594451 YP_001460744.1 CDS EcHS_A4183 NC_009800.1 4172442 4173521 D FrwC with FrwB, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; forms translocation channel and contains the specific substrate-binding site; fructose-like permease EIIC subunit 2 4172442..4173521 Escherichia coli HS 5594452 YP_001460745.1 CDS EcHS_A4184 NC_009800.1 4173536 4173856 D FrwB with FrwC, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system (PTS) permease which may phosphorylate and transport sugars into the cell; cytoplasmic protein that interacts with complex EIIA; contains the second phosphorylation site of the PTS; fructose-like phosphotransferase EIIB subunit 2 4173536..4173856 Escherichia coli HS 5594453 YP_001460746.1 CDS pflD NC_009800.1 4173907 4176204 D involved in production of D-lactate from glucose under microaerobic conditions; cytoplasmic protein; formate acetyltransferase 2 4173907..4176204 Escherichia coli HS 5594454 YP_001460747.1 CDS EcHS_A4186 NC_009800.1 4176170 4177048 D identified by match to protein family HMM PF04055; match to protein family HMM TIGR02494; pyruvate formate lyase II activase 4176170..4177048 Escherichia coli HS 5591198 YP_001460748.1 CDS EcHS_A4187 NC_009800.1 4177050 4177391 D FrwD with FrwB, FrwC and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; phosphorylated by EIIA; FrwB homolog; fructose-like phosphotransferase EIIB subunit 3 4177050..4177391 Escherichia coli HS 5591199 YP_001460749.1 CDS EcHS_A4188 NC_009800.1 4177378 4178229 R identified by match to protein family HMM PF00165; AraC family transcriptional regulator complement(4177378..4178229) Escherichia coli HS 5591200 YP_001460750.1 CDS EcHS_A4189 NC_009800.1 4178444 4180177 R identified by match to protein family HMM PF00884; hypothetical protein complement(4178444..4180177) Escherichia coli HS 5591201 YP_001460751.1 CDS ppc NC_009800.1 4180359 4183010 R catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase complement(4180359..4183010) Escherichia coli HS 5594138 YP_001460752.1 CDS argE NC_009800.1 4183362 4184513 R catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis; acetylornithine deacetylase complement(4183362..4184513) Escherichia coli HS 5594139 YP_001460753.1 CDS argC NC_009800.1 4184667 4185671 D catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase 4184667..4185671 Escherichia coli HS 5594140 YP_001460754.1 CDS argB NC_009800.1 4185682 4186455 D catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 4185682..4186455 Escherichia coli HS 5594141 YP_001460755.1 CDS argH NC_009800.1 4186516 4187889 D catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 4186516..4187889 Escherichia coli HS 5594502 YP_001460756.1 CDS oxyR NC_009800.1 4188156 4189073 D Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA; DNA-binding transcriptional regulator OxyR 4188156..4189073 Escherichia coli HS 5594504 YP_001460757.1 CDS sthA NC_009800.1 4189056 4190456 R catalyzes the conversion of NADPH to NADH; soluble pyridine nucleotide transhydrogenase complement(4189056..4190456) Escherichia coli HS 5594459 YP_001460758.1 CDS fabR NC_009800.1 4190790 4191437 D negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis; DNA-binding transcriptional repressor FabR 4190790..4191437 Escherichia coli HS 5594460 YP_001460759.1 CDS EcHS_A4198 NC_009800.1 4191437 4191796 D yijD; identified by match to protein family HMM PF07226; hypothetical protein 4191437..4191796 Escherichia coli HS 5594461 YP_001460760.1 CDS trmA NC_009800.1 4191836 4192936 R catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs; tRNA (uracil-5-)-methyltransferase complement(4191836..4192936) Escherichia coli HS 5594462 YP_001460761.1 CDS btuB NC_009800.1 4193305 4195149 D involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space; vitamin B12/cobalamin outer membrane transporter 4193305..4195149 Escherichia coli HS 5593602 YP_001460762.1 CDS murI NC_009800.1 4195094 4195951 D converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 4195094..4195951 Escherichia coli HS 5593603 YP_001460763.1 CDS murB NC_009800.1 4201639 4202667 D catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 4201639..4202667 Escherichia coli HS 5594194 YP_001460764.1 CDS birA NC_009800.1 4202664 4203629 D catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 4202664..4203629 Escherichia coli HS 5593140 YP_001460765.1 CDS coaA NC_009800.1 4203658 4204608 R catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase complement(4203658..4204608) Escherichia coli HS 5593141 YP_001460766.1 CDS tuf1 NC_009800.1 4205526 4206710 D EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 4205526..4206710 Escherichia coli HS 5594134 YP_001460767.1 CDS secE NC_009800.1 4206940 4207323 D forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 4206940..4207323 Escherichia coli HS 5594969 YP_001460768.1 CDS nusG NC_009800.1 4207325 4207870 D Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 4207325..4207870 Escherichia coli HS 5594970 YP_001460769.1 CDS rplK NC_009800.1 4208029 4208457 D binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 4208029..4208457 Escherichia coli HS 5592473 YP_001460770.1 CDS rplA NC_009800.1 4208461 4209165 D in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 4208461..4209165 Escherichia coli HS 5592474 YP_001460771.1 CDS rplJ NC_009800.1 4209578 4210075 D binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 4209578..4210075 Escherichia coli HS 5592475 YP_001460772.1 CDS rplL NC_009800.1 4210142 4210507 D present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 4210142..4210507 Escherichia coli HS 5592476 YP_001460773.1 CDS rpoB NC_009800.1 4210827 4214855 D DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 4210827..4214855 Escherichia coli HS 5594854 YP_001460774.1 CDS rpoC NC_009800.1 4214932 4219155 D DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 4214932..4219155 Escherichia coli HS 5594855 YP_001460775.1 CDS htrC NC_009800.1 4219368 4219907 D identified by similarity to SP:P27375; heat shock protein 4219368..4219907 Escherichia coli HS 5594856 YP_001460776.1 CDS thiH NC_009800.1 4220317 4221450 R in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center; thiamine biosynthesis protein ThiH complement(4220317..4221450) Escherichia coli HS 5591086 YP_001460777.1 CDS thiG NC_009800.1 4221447 4222217 R functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase complement(4221447..4222217) Escherichia coli HS 5591087 YP_001460778.1 CDS thiS NC_009800.1 4222219 4222419 R with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate; sulfur carrier protein ThiS complement(4222219..4222419) Escherichia coli HS 5591088 YP_001460779.1 CDS thiF NC_009800.1 4222403 4223158 R identified by similarity to SP:P30138; match to protein family HMM PF00899; match to protein family HMM PF05237; match to protein family HMM TIGR02356; thiazole biosynthesis adenylyltransferase ThiF complement(4222403..4223158) Escherichia coli HS 5591986 YP_001460780.1 CDS thiE NC_009800.1 4223151 4223786 R catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate; thiamine-phosphate pyrophosphorylase complement(4223151..4223786) Escherichia coli HS 5591987 YP_001460781.1 CDS thiC NC_009800.1 4223786 4225681 R required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC complement(4223786..4225681) Escherichia coli HS 5591988 YP_001460782.1 CDS rsd NC_009800.1 4225914 4226390 R binds specifically to the major sigma factor sigma 70; active in stationary phase; anti-RNA polymerase sigma 70 factor complement(4225914..4226390) Escherichia coli HS 5591989 YP_001460783.1 CDS nudC NC_009800.1 4226485 4227258 D can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates; NADH pyrophosphatase 4226485..4227258 Escherichia coli HS 5593120 YP_001460784.1 CDS hemE NC_009800.1 4227298 4228362 D catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 4227298..4228362 Escherichia coli HS 5593121 YP_001460785.1 CDS nfi NC_009800.1 4228372 4229043 D Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA; cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures; endonuclease V 4228372..4229043 Escherichia coli HS 5593122 YP_001460786.1 CDS EcHS_A4233 NC_009800.1 4229086 4229676 D identified by similarity to SP:P32680; match to protein family HMM PF04222; hypothetical protein 4229086..4229676 Escherichia coli HS 5593123 YP_001460787.1 CDS hupA NC_009800.1 4229863 4230135 D histone-like DNA-binding protein; transcriptional regulator HU subunit alpha 4229863..4230135 Escherichia coli HS 5591580 YP_001460788.1 CDS EcHS_A4235 NC_009800.1 4230148 4230843 D yjaH; identified by match to protein family HMM PF07356; hypothetical protein 4230148..4230843 Escherichia coli HS 5591581 YP_001460789.1 CDS zraP NC_009800.1 4230845 4231270 R identified by similarity to SP:P0AAA9; zinc resistance protein complement(4230845..4231270) Escherichia coli HS 5591582 YP_001460790.1 CDS zraS NC_009800.1 4231508 4232884 D identified by similarity to SP:P14377; match to protein family HMM PF00512; match to protein family HMM PF02518; sensor protein ZraS 4231508..4232884 Escherichia coli HS 5591583 YP_001460791.1 CDS zraR NC_009800.1 4232881 4234206 D DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein; transcriptional regulatory protein ZraR 4232881..4234206 Escherichia coli HS 5595423 YP_001460792.1 CDS purD NC_009800.1 4234203 4235492 R catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase complement(4234203..4235492) Escherichia coli HS 5595424 YP_001460793.1 CDS purH NC_009800.1 4235504 4237093 R involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase complement(4235504..4237093) Escherichia coli HS 5595425 YP_001460794.1 CDS EcHS_A4241 NC_009800.1 4237211 4237333 D identified by glimmer; hypothetical protein 4237211..4237333 Escherichia coli HS 5595426 YP_001460795.1 CDS EcHS_A4246 NC_009800.1 4242836 4243279 R identified by match to protein family HMM PF00583; hypothetical protein complement(4242836..4243279) Escherichia coli HS 5594482 YP_001460796.1 CDS metA NC_009800.1 4243436 4244365 D catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase 4243436..4244365 Escherichia coli HS 5594483 YP_001460797.1 CDS aceB NC_009800.1 4244634 4246235 D Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle; malate synthase 4244634..4246235 Escherichia coli HS 5594484 YP_001460798.1 CDS aceA NC_009800.1 4246265 4247569 D identified by match to protein family HMM PF00463; match to protein family HMM TIGR01346; isocitrate lyase 4246265..4247569 Escherichia coli HS 5593876 YP_001460799.1 CDS EcHS_A4250 NC_009800.1 4247638 4247874 D identified by glimmer; hypothetical protein 4247638..4247874 Escherichia coli HS 5593877 YP_001460800.1 CDS aceK NC_009800.1 4247850 4249586 D catalyzes the phosphorylation/dephosphorylation of the enzyme isocitrate dehydrogenase on a specific serine which regulates activity; unphosphorylated IDH is fully active when cells are grown on glucose while the enzyme becomes phosphorylated and inactive in the presence of acetate or ethanol; bifunctional isocitrate dehydrogenase kinase/phosphatase 4247850..4249586 Escherichia coli HS 5593878 YP_001460801.1 CDS iclR NC_009800.1 4251445 4252269 R regulates the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase and isocitrate dehydrogenase kinase/phosphorylase; transcriptional repressor IclR complement(4251445..4252269) Escherichia coli HS 5594595 YP_001460802.1 CDS metH NC_009800.1 4252469 4256152 D one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity; B12-dependent methionine synthase 4252469..4256152 Escherichia coli HS 5594596 YP_001460803.1 CDS pNaS NC_009800.1 4256372 4258003 D identified by match to protein family HMM PF02690; match to protein family HMM TIGR00704; match to protein family HMM TIGR01013; inorganic phosphate transporter sodium-dependent 4256372..4258003 Escherichia coli HS 5594597 YP_001460804.1 CDS pepE NC_009800.1 4258094 4258783 R alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family; peptidase E complement(4258094..4258783) Escherichia coli HS 5594598 YP_001460805.1 CDS rluF NC_009800.1 4258995 4259867 D catalyzes the synthesis of pseudouridine from U-2604 in the 23S ribosomal RNA; 23S rRNA pseudouridine synthase F 4258995..4259867 Escherichia coli HS 5592281 YP_001460806.1 CDS EcHS_A4259 NC_009800.1 4260000 4260272 R yjbD; identified by similarity to GB:AAZ90700.1; hypothetical protein complement(4260000..4260272) Escherichia coli HS 5592282 YP_001460807.1 CDS EcHS_A4260 NC_009800.1 4260802 4261929 D identified by match to protein family HMM PF01145; SPFH domain-containing protein 4260802..4261929 Escherichia coli HS 5592283 YP_001460808.1 CDS EcHS_A4261 NC_009800.1 4261962 4262726 D identified by similarity to GB:CAD13753.1; hypothetical protein 4261962..4262726 Escherichia coli HS 5592284 YP_001460809.1 CDS EcHS_A4262 NC_009800.1 4262762 4263688 R identified by match to protein family HMM PF06414; zeta toxin complement(4262762..4263688) Escherichia coli HS 5591633 YP_001460810.1 CDS lysC NC_009800.1 4263833 4265182 R catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive; aspartate kinase complement(4263833..4265182) Escherichia coli HS 5591634 YP_001460811.1 CDS pgi NC_009800.1 4265707 4267356 D functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 4265707..4267356 Escherichia coli HS 5591635 YP_001460812.1 CDS EcHS_A4265 NC_009800.1 4267705 4267947 D yjbE; hypothetical protein 4267705..4267947 Escherichia coli HS 5593185 YP_001460813.1 CDS EcHS_A4266 NC_009800.1 4268031 4268699 D yjbF; hypothetical protein 4268031..4268699 Escherichia coli HS 5593186 YP_001460814.1 CDS EcHS_A4267 NC_009800.1 4268696 4269433 D yjbG; identified by match to protein family HMM PF06251; hypothetical protein 4268696..4269433 Escherichia coli HS 5593187 YP_001460815.1 CDS EcHS_A4268 NC_009800.1 4269433 4271529 D yjbH; identified by match to protein family HMM PF06082; lipoprotein 4269433..4271529 Escherichia coli HS 5593188 YP_001460816.1 CDS EcHS_A4269 NC_009800.1 4271576 4271854 R identified by similarity to GB:ABB68492.1; hypothetical protein complement(4271576..4271854) Escherichia coli HS 5594930 YP_001460817.1 CDS psiE NC_009800.1 4272069 4272479 D yjbA; identified by match to protein family HMM PF06146; phosphate-starvation-inducible protein PsiE 4272069..4272479 Escherichia coli HS 5594931 YP_001460818.1 CDS xylE NC_009800.1 4272523 4273998 R xylose/proton symporter; member of the major facilitator superfamily (MFS) of transporter; D-xylose transporter XylE complement(4272523..4273998) Escherichia coli HS 5594932 YP_001460819.1 CDS malG NC_009800.1 4274370 4275260 R with MalKFE is involved in the transport of maltose into the cell; maltose transporter permease complement(4274370..4275260) Escherichia coli HS 5594933 YP_001460820.1 CDS malF NC_009800.1 4275275 4276819 R with MalKGE is involved in maltose transport into the cell; maltose transporter membrane protein complement(4275275..4276819) Escherichia coli HS 5594199 YP_001460821.1 CDS malE NC_009800.1 4276973 4278163 R functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis; maltose ABC transporter periplasmic protein complement(4276973..4278163) Escherichia coli HS 5594200 YP_001460822.1 CDS malK NC_009800.1 4278528 4279643 D with malEFG is involved in import of maltose/maltodextrin; maltose/maltodextrin transporter ATP-binding protein 4278528..4279643 Escherichia coli HS 5594201 YP_001460823.1 CDS lamB NC_009800.1 4279715 4281055 D porin involved in the transport of maltose and maltodextrins; maltoporin 4279715..4281055 Escherichia coli HS 5594202 YP_001460824.1 CDS malM NC_009800.1 4281298 4282218 D identified by match to protein family HMM PF07148; maltose regulon periplasmic protein 4281298..4282218 Escherichia coli HS 5593810 YP_001460825.1 CDS EcHS_A4278 NC_009800.1 4282732 4284027 D yjbI; hypothetical protein 4282732..4284027 Escherichia coli HS 5593811 YP_001460826.1 CDS ubiC NC_009800.1 4284250 4284747 D catalyzes the formation of 4-hydroxybenzoate from chorismate; chorismate pyruvate lyase 4284250..4284747 Escherichia coli HS 5593812 YP_001460827.1 CDS ubiA NC_009800.1 4284760 4285632 D catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway; 4-hydroxybenzoate octaprenyltransferase 4284760..4285632 Escherichia coli HS 5593813 YP_001460828.1 CDS plsB NC_009800.1 4285787 4288210 R PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase complement(4285787..4288210) Escherichia coli HS 5595345 YP_001460829.1 CDS dgkA NC_009800.1 4288381 4288749 D identified by similarity to SP:P0ABN1; match to protein family HMM PF01219; diacylglycerol kinase 4288381..4288749 Escherichia coli HS 5595346 YP_001460830.1 CDS lexA NC_009800.1 4288859 4289467 D Represses a number of genes involved in the response to DNA damage; LexA repressor 4288859..4289467 Escherichia coli HS 5595347 YP_001460831.1 CDS dinF NC_009800.1 4289486 4290865 D identified by similarity to SP:P28303; match to protein family HMM PF01554; match to protein family HMM TIGR00797; DNA-damage-inducible SOS response protein 4289486..4290865 Escherichia coli HS 5595348 YP_001460832.1 CDS EcHS_A4285 NC_009800.1 4290981 4291190 D unknown function; highly abundant protein in vivo; overexpressed under high NaCl concentrations; part of the sigma S regulon; non-essential; stress-response protein 4290981..4291190 Escherichia coli HS 5595364 YP_001460833.1 CDS zur NC_009800.1 4291232 4291747 R Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes znuACB; zinc uptake transcriptional repressor complement(4291232..4291747) Escherichia coli HS 5595365 YP_001460834.1 CDS EcHS_A4287 NC_009800.1 4292065 4292319 D identified by glimmer; hypothetical protein 4292065..4292319 Escherichia coli HS 5595366 YP_001460835.1 CDS EcHS_A4288 NC_009800.1 4292343 4293050 D identified by similarity to GB:AAZ90726.1; hypothetical protein 4292343..4293050 Escherichia coli HS 5595367 YP_001460836.1 CDS EcHS_A4289 NC_009800.1 4293106 4293231 D identified by glimmer; hypothetical protein 4293106..4293231 Escherichia coli HS 5595434 YP_001460837.1 CDS dusA NC_009800.1 4293407 4294450 D yjbN; identified by similarity to SP:P32695; match to protein family HMM PF01207; match to protein family HMM TIGR00742; tRNA-dihydrouridine synthase A 4293407..4294450 Escherichia coli HS 5595435 YP_001460838.1 CDS qor NC_009800.1 4294992 4295975 R identified by similarity to SP:P28304; match to protein family HMM PF00107; match to protein family HMM PF08240; quinone oxidoreductase, NADPH-dependent complement(4294992..4295975) Escherichia coli HS 5595436 YP_001460839.1 CDS dnaB NC_009800.1 4296058 4297473 D unwinds double stranded DNA; replicative DNA helicase 4296058..4297473 Escherichia coli HS 5595437 YP_001460840.1 CDS alr NC_009800.1 4297526 4298605 D converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 4297526..4298605 Escherichia coli HS 5593446 YP_001460841.1 CDS tyrB NC_009800.1 4298858 4300051 D catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 4298858..4300051 Escherichia coli HS 5593447 YP_001460842.1 CDS EcHS_A4295 NC_009800.1 4300273 4300776 R hypothetical protein complement(4300273..4300776) Escherichia coli HS 5593448 YP_001460843.1 CDS EcHS_A4298 NC_009800.1 4302003 4302419 D yjbQ; identified by match to protein family HMM PF01894; match to protein family HMM TIGR00149; hypothetical protein 4302003..4302419 Escherichia coli HS 5591364 YP_001460844.1 CDS EcHS_A4299 NC_009800.1 4302423 4302779 D yjbR; identified by match to protein family HMM PF04237; hypothetical protein 4302423..4302779 Escherichia coli HS 5591365 YP_001460845.1 CDS uvrA NC_009800.1 4302814 4305636 R The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A complement(4302814..4305636) Escherichia coli HS 5591366 YP_001460846.1 CDS ssb NC_009800.1 4305890 4306426 D binds to single stranded DNA and PriA helcase facilitate replication restart; single-stranded DNA-binding protein 4305890..4306426 Escherichia coli HS 5591367 YP_001460847.1 CDS EcHS_A4302 NC_009800.1 4306525 4306806 R yjcB; hypothetical protein complement(4306525..4306806) Escherichia coli HS 5591337 YP_001460848.1 CDS EcHS_A4303 NC_009800.1 4307236 4308822 D yjcC; identified by match to protein family HMM PF00563; cyclic diguanylate phosphodiesterase domain-containing protein 4307236..4308822 Escherichia coli HS 5591338 YP_001460849.1 CDS soxS NC_009800.1 4308825 4309148 R regulates genes involved in response to oxidative stress; DNA-binding transcriptional regulator SoxS complement(4308825..4309148) Escherichia coli HS 5591339 YP_001460850.1 CDS soxR NC_009800.1 4309234 4309698 D identified by match to protein family HMM PF00376; match to protein family HMM PF09278; match to protein family HMM TIGR01950; redox-sensitive transcriptional activator SoxR 4309234..4309698 Escherichia coli HS 5591340 YP_001460851.1 CDS EcHS_A4306 NC_009800.1 4309989 4310207 R identified by glimmer; hypothetical protein complement(4309989..4310207) Escherichia coli HS 5591292 YP_001460852.1 CDS EcHS_A4307 NC_009800.1 4310244 4311593 D yjcD; identified by match to protein family HMM PF00860; match to protein family HMM PF00916; sulfate permease inorganic anion transporter 4310244..4311593 Escherichia coli HS 5591293 YP_001460853.1 CDS EcHS_A4308 NC_009800.1 4311745 4313394 D identified by match to protein family HMM PF00999; match to protein family HMM TIGR00831; Na+/H+ antiporter 4311745..4313394 Escherichia coli HS 5591294 YP_001460854.1 CDS actP NC_009800.1 4315018 4316667 R member of the sodium:solute symporter family; cotranscribed with the acs gene which encodes acetyl coenzyme A synthase; mutations affect acetate uptake; acetate permease complement(4315018..4316667) Escherichia coli HS 5591542 YP_001460855.1 CDS EcHS_A4312 NC_009800.1 4316664 4316978 R yjcH; identified by match to protein family HMM PF04341; hypothetical protein complement(4316664..4316978) Escherichia coli HS 5591543 YP_001460856.1 CDS EcHS_A4313 NC_009800.1 4316978 4317103 R identified by glimmer; hypothetical protein complement(4316978..4317103) Escherichia coli HS 5591544 YP_001460857.1 CDS acsA NC_009800.1 4317179 4319137 R Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA; acetyl-CoA synthetase complement(4317179..4319137) Escherichia coli HS 5591368 YP_001460858.1 CDS nrfA NC_009800.1 4319530 4320966 D catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552; cytochrome c552 4319530..4320966 Escherichia coli HS 5591369 YP_001460859.1 CDS nrfB NC_009800.1 4321011 4321577 D part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia; cytochrome c nitrite reductase pentaheme subunit 4321011..4321577 Escherichia coli HS 5591370 YP_001460860.1 CDS nrfC NC_009800.1 4321574 4322245 D identified by match to protein family HMM PF00037; match to protein family HMM TIGR01409; match to protein family HMM TIGR03149; cytochrome c nitrite reductase, Fe-S protein 4321574..4322245 Escherichia coli HS 5591371 YP_001460861.1 CDS nrfD NC_009800.1 4322242 4323198 D identified by similarity to SP:P32709; match to protein family HMM PF03916; match to protein family HMM TIGR03148; nrfD protein 4322242..4323198 Escherichia coli HS 5595072 YP_001460862.1 CDS nrfE NC_009800.1 4323278 4324936 D with NrfF and NrfG catalyzes the insertion of heme into cytochrome c552; heme lyase subunit NrfE 4323278..4324936 Escherichia coli HS 5595073 YP_001460863.1 CDS nrfF NC_009800.1 4324929 4325312 D identified by similarity to SP:P32711; match to protein family HMM PF03918; match to protein family HMM TIGR03147; formate-dependent nitrite reductase complex subunit NrfF 4324929..4325312 Escherichia coli HS 5595074 YP_001460864.1 CDS nrfG NC_009800.1 4325309 4325905 D identified by similarity to SP:P32712; match to protein family HMM PF00515; match to protein family HMM PF07719; formate-dependent nitrite reductase complex subunit NrfG 4325309..4325905 Escherichia coli HS 5595075 YP_001460865.1 CDS gltP NC_009800.1 4326247 4327560 D carrier protein part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system; glutamate/aspartate:proton symporter 4326247..4327560 Escherichia coli HS 5591329 YP_001460866.1 CDS EcHS_A4323 NC_009800.1 4327638 4328327 R yjcO; identified by match to protein family HMM PF08238; Sel1 repeat-containing protein complement(4327638..4328327) Escherichia coli HS 5591330 YP_001460867.1 CDS fdhF NC_009800.1 4328421 4330568 R Selenoprotein. identified by similarity to SP:P07658; match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM PF04879; match to protein family HMM TIGR01591; formate dehydrogenase H, alpha subunit, selenocysteine-containing complement(4328421..4330568) Escherichia coli HS 5591331 YP_001460868.1 CDS EcHS_A4325 NC_009800.1 4330766 4332232 R part of a multidrug efflux system involved in resistance to acriflavin, puromycin, erytjhromycin and tetraphenylarsonium chloride; member of the outer membrane factor (OMF) family; outer membrane efflux protein MdtP complement(4330766..4332232) Escherichia coli HS 5591332 YP_001460869.1 CDS mdtO NC_009800.1 4332229 4334280 R possibly part of a tripartite efflux system composed of MdtN, MdtO and MdtP which could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug efflux system protein MdtO complement(4332229..4334280) Escherichia coli HS 5591764 YP_001460870.1 CDS mdtN NC_009800.1 4334280 4335311 R with MdtO and MdtP is involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug resistance protein MdtN complement(4334280..4335311) Escherichia coli HS 5591765 YP_001460871.1 CDS EcHS_A4328 NC_009800.1 4335330 4335653 R hypothetical protein complement(4335330..4335653) Escherichia coli HS 5591766 YP_001460872.1 CDS EcHS_A4329 NC_009800.1 4335814 4337799 R yjcS; identified by match to protein family HMM PF00753; metallo-beta-lactamase superfamily protein complement(4335814..4337799) Escherichia coli HS 5591767 YP_001460873.1 CDS EcHS_A4330 NC_009800.1 4337993 4338160 D identified by glimmer; hypothetical protein 4337993..4338160 Escherichia coli HS 5595045 YP_001460874.1 CDS EcHS_A4331 NC_009800.1 4338133 4338369 D identified by match to protein family HMM PF02502; ribose-5-phosphate isomerase B, truncation 4338133..4338369 Escherichia coli HS 5595046 YP_001460875.1 CDS EcHS_A4332 NC_009800.1 4338462 4338788 R identified by glimmer; hypothetical protein complement(4338462..4338788) Escherichia coli HS 5595047 YP_001460876.1 CDS phnP NC_009800.1 4338914 4339672 R required for the use of phosphonates and phosphite as phosphorus sources; carbon-phosphorus lyase complex accessory protein complement(4338914..4339672) Escherichia coli HS 5595048 YP_001460877.1 CDS EcHS_A4334 NC_009800.1 4339674 4340108 R PhnO in Salmonella enterica catalyzes the acetylation of a range of aminoalkylphosphonic acids; part of the biochemical pathway that enables the cell to use phosphonates as a phosphorus source; Escherichia coli uses a different mechanism of phosphonate catabolism where PhnO is not essential and seems to play a regulatory role; aminoalkylphosphonic acid N-acetyltransferase complement(4339674..4340108) Escherichia coli HS 5591593 YP_001460878.1 CDS phnN NC_009800.1 4340095 4340652 R identified by similarity to SP:P16690; match to protein family HMM TIGR02322; ribose 1,5-bisphosphokinase complement(4340095..4340652) Escherichia coli HS 5591594 YP_001460879.1 CDS phnM NC_009800.1 4340652 4341788 R identified by match to protein family HMM PF01979; match to protein family HMM PF07969; match to protein family HMM TIGR02318; phosphonate metabolism protein PhnM complement(4340652..4341788) Escherichia coli HS 5591595 YP_001460880.1 CDS phnL NC_009800.1 4341785 4342465 R identified by similarity to SP:P16679; match to protein family HMM PF00005; match to protein family HMM TIGR02324; phosphonate C-P lyase system protein PhnL complement(4341785..4342465) Escherichia coli HS 5591596 YP_001460881.1 CDS phnK NC_009800.1 4342576 4343334 R identified by similarity to SP:P16678; match to protein family HMM PF00005; match to protein family HMM TIGR02323; phosphonate C-P lyase system protein PhnK complement(4342576..4343334) Escherichia coli HS 5594013 YP_001460882.1 CDS phnJ NC_009800.1 4343331 4344176 R identified by similarity to SP:P16688; match to protein family HMM PF06007; phosphonate metabolism protein PhnJ complement(4343331..4344176) Escherichia coli HS 5594014 YP_001460883.1 CDS phnI NC_009800.1 4344169 4345233 R identified by similarity to SP:P16687; match to protein family HMM PF05861; phosphonate metabolism protein PhnI complement(4344169..4345233) Escherichia coli HS 5594015 YP_001460884.1 CDS phnH NC_009800.1 4345233 4345817 R identified by match to protein family HMM PF05845; carbon-phosphorus lyase complex subunit complement(4345233..4345817) Escherichia coli HS 5594016 YP_001460885.1 CDS phnG NC_009800.1 4345814 4346266 R identified by similarity to SP:P16685; match to protein family HMM PF06754; match to protein family HMM TIGR03293; phosphonate C-P lyase system protein PhnG complement(4345814..4346266) Escherichia coli HS 5594416 YP_001460886.1 CDS phnF NC_009800.1 4346267 4346992 R may be involved in phosphonate uptake and biodegradation; phosphonate metabolism transcriptional regulator PhnF complement(4346267..4346992) Escherichia coli HS 5594417 YP_001460887.1 CDS phnE NC_009800.1 4347013 4347792 R identified by similarity to SP:P16683; match to protein family HMM PF00528; match to protein family HMM TIGR01097; phosphonate ABC transporter permease complement(4347013..4347792) Escherichia coli HS 5594418 YP_001460888.1 CDS phnD NC_009800.1 4347854 4348870 R identified by similarity to SP:P16682; match to protein family HMM TIGR01098; match to protein family HMM TIGR03431; phosphonate ABC transporter periplasmic phosphonate-binding protein complement(4347854..4348870) Escherichia coli HS 5594419 YP_001460889.1 CDS phnC NC_009800.1 4348895 4349683 R identified by similarity to SP:P16677; match to protein family HMM PF00005; match to protein family HMM TIGR02315; phosphonate/organophosphate ester transporter subunit complement(4348895..4349683) Escherichia coli HS 5591003 YP_001460890.1 CDS EcHS_A4347 NC_009800.1 4349816 4350259 R identified by similarity to SP:P16681; match to protein family HMM PF00903; hypothetical protein complement(4349816..4350259) Escherichia coli HS 5591004 YP_001460891.1 CDS phnA NC_009800.1 4350419 4350754 R identified by match to protein family HMM PF03831; match to protein family HMM PF08274; match to protein family HMM TIGR00686; hypothetical protein complement(4350419..4350754) Escherichia coli HS 5591005 YP_001460892.1 CDS EcHS_A4349 NC_009800.1 4351156 4353384 D hypothetical protein 4351156..4353384 Escherichia coli HS 5591006 YP_001460893.1 CDS EcHS_A4350 NC_009800.1 4353414 4354259 D yjcZ; hypothetical protein 4353414..4354259 Escherichia coli HS 5594376 YP_001460894.1 CDS proP NC_009800.1 4354523 4356025 D identified by match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM PF08946; match to protein family HMM TIGR00883; proline/glycine betaine transporter 4354523..4356025 Escherichia coli HS 5594377 YP_001460895.1 CDS basS NC_009800.1 4356202 4357293 R identified by similarity to SP:P30844; match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; sensor protein BasS/PmrB complement(4356202..4357293) Escherichia coli HS 5594378 YP_001460896.1 CDS basR NC_009800.1 4357303 4357971 R response regulator in two-component regulatory system with BasS; DNA-binding transcriptional regulator BasR complement(4357303..4357971) Escherichia coli HS 5594379 YP_001460897.1 CDS EcHS_A4354 NC_009800.1 4357968 4359641 R with ZipA and an unidentified 24 kDa protein forms a complex involved in cell division; cell division protein complement(4357968..4359641) Escherichia coli HS 5593901 YP_001460898.1 CDS adiC NC_009800.1 4359715 4361052 R identified by similarity to SP:P60061; match to protein family HMM PF00324; arginine:agmatin antiporter complement(4359715..4361052) Escherichia coli HS 5593902 YP_001460899.1 CDS adiY NC_009800.1 4361189 4361950 R identified by similarity to GB:AAB18143.1; match to protein family HMM PF00165; transcriptional regulator AdiY complement(4361189..4361950) Escherichia coli HS 5593903 YP_001460900.1 CDS EcHS_A4357 NC_009800.1 4362082 4362186 R identified by glimmer; hypothetical protein complement(4362082..4362186) Escherichia coli HS 5593904 YP_001460901.1 CDS adiA NC_009800.1 4362275 4364545 R identified by match to protein family HMM PF01276; match to protein family HMM PF03709; match to protein family HMM PF03711; biodegradative arginine decarboxylase complement(4362275..4364545) Escherichia coli HS 5594345 YP_001460902.1 CDS melR NC_009800.1 4364741 4365649 R identified by similarity to SP:P10411; match to protein family HMM PF00165; DNA-binding transcriptional regulator MelR complement(4364741..4365649) Escherichia coli HS 5594346 YP_001460903.1 CDS melA NC_009800.1 4365932 4367287 D identified by similarity to SP:P06720; match to protein family HMM PF02056; alpha-galactosidase 4365932..4367287 Escherichia coli HS 5594347 YP_001460904.1 CDS melB NC_009800.1 4367390 4368811 D identified by similarity to SP:P02921; match to protein family HMM TIGR00792; melibiose:sodium symporter 4367390..4368811 Escherichia coli HS 5594348 YP_001460905.1 CDS EcHS_A4362 NC_009800.1 4368950 4369579 R yjdF; hypothetical protein complement(4368950..4369579) Escherichia coli HS 5592181 YP_001460906.1 CDS fumB NC_009800.1 4369702 4371348 R identified by similarity to SP:P14407; match to protein family HMM PF05681; match to protein family HMM PF05683; match to protein family HMM TIGR00722; match to protein family HMM TIGR00723; fumarate hydratase complement(4369702..4371348) Escherichia coli HS 5592182 YP_001460907.1 CDS dcuB NC_009800.1 4371426 4372766 R functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters; anaerobic C4-dicarboxylate transporter complement(4371426..4372766) Escherichia coli HS 5592183 YP_001460908.1 CDS dcuR NC_009800.1 4373337 4374056 R response regulator in two-component regulatory system with DcuS; phosphorylated DcuR activates transcription of genes involved in anaerobic fumarate respiration; DNA-binding transcriptional activator DcuR complement(4373337..4374056) Escherichia coli HS 5592184 YP_001460909.1 CDS dcuS NC_009800.1 4374053 4375684 R C4-dicarboxylate-sensing histidine kinase; part of two-component regulatory system with DcuR; regulates anaerobic fumarate respiration; sensory histidine kinase DcuS complement(4374053..4375684) Escherichia coli HS 5592118 YP_001460910.1 CDS EcHS_A4367 NC_009800.1 4375865 4376095 D yjdI; identified by match to protein family HMM PF06902; hypothetical protein 4375865..4376095 Escherichia coli HS 5592119 YP_001460911.1 CDS EcHS_A4368 NC_009800.1 4376107 4376379 D yjdJ; hypothetical protein 4376107..4376379 Escherichia coli HS 5592120 YP_001460912.1 CDS EcHS_A4369 NC_009800.1 4376930 4377103 D identified by similarity to GB:AAV77221.1; hypothetical protein 4376930..4377103 Escherichia coli HS 5592121 YP_001460913.1 CDS lysS1 NC_009800.1 4377222 4378739 R class II; inducible; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; induced by high temperature, anaerobiosis, and low pH; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase complement(4377222..4378739) Escherichia coli HS 5593369 YP_001460914.1 CDS EcHS_A4371 NC_009800.1 4378976 4380433 R identified by match to protein family HMM PF00854; match to protein family HMM PF07690; match to protein family HMM TIGR00924; amino acid/peptide transporter complement(4378976..4380433) Escherichia coli HS 5593370 YP_001460915.1 CDS ldcC2 NC_009800.1 4380492 4382639 R identified by match to protein family HMM PF01276; match to protein family HMM PF03709; match to protein family HMM PF03711; lysine decarboxylase, constitutive complement(4380492..4382639) Escherichia coli HS 5593371 YP_001460916.1 CDS cadB NC_009800.1 4382719 4384053 R antiporter protein responsible for lysine import and cadaverine export; member of the lysine-dependent acid resistance system 4 (AR4); inner membrane protein; lysine/cadaverine antiporter complement(4382719..4384053) Escherichia coli HS 5593372 YP_001460917.1 CDS cadC NC_009800.1 4384419 4385957 R regulates the cadBA operon; DNA-binding transcriptional activator CadC complement(4384419..4385957) Escherichia coli HS 5590982 YP_001460918.1 CDS EcHS_A4376 NC_009800.1 4386756 4387331 R yjdC; identified by match to protein family HMM PF00440; transcriptional regulator complement(4386756..4387331) Escherichia coli HS 5590984 YP_001460919.1 CDS dipZ NC_009800.1 4387368 4389065 R two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm; thiol:disulfide interchange protein precursor complement(4387368..4389065) Escherichia coli HS 5591884 YP_001460920.1 CDS cutA NC_009800.1 4389041 4389379 R copper binding protein required for copper tolerance; involved in resistance toward heavy metals; divalent-cation tolerance protein CutA complement(4389041..4389379) Escherichia coli HS 5591885 YP_001460921.1 CDS dcuA NC_009800.1 4389495 4390796 R functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB; anaerobic C4-dicarboxylate transporter complement(4389495..4390796) Escherichia coli HS 5591886 YP_001460922.1 CDS aspA NC_009800.1 4390914 4392350 R catalyzes the formation of fumarate from aspartate; aspartate ammonia-lyase complement(4390914..4392350) Escherichia coli HS 5591887 YP_001460923.1 CDS fxsA NC_009800.1 4392687 4393163 D F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein; FxsA 4392687..4393163 Escherichia coli HS 5592460 YP_001460924.1 CDS EcHS_A4382 NC_009800.1 4393179 4394435 R uncharacterized member of the APC superfamily of amino acid transporters; unknown function; hypothetical protein complement(4393179..4394435) Escherichia coli HS 5592461 YP_001460925.1 CDS groES NC_009800.1 4394711 4395004 D 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 4394711..4395004 Escherichia coli HS 5592462 YP_001460926.1 CDS groEL NC_009800.1 4395048 4396694 D 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; molecular chaperone GroEL 4395048..4396694 Escherichia coli HS 5592463 YP_001460927.1 CDS EcHS_A4385 NC_009800.1 4396832 4397185 D yjeI; lipoprotein 4396832..4397185 Escherichia coli HS 5592941 YP_001460928.1 CDS EcHS_A4386 NC_009800.1 4397438 4398418 D identified by match to protein family HMM PF01548; match to protein family HMM PF02371; IS621, transposase 4397438..4398418 Escherichia coli HS 5592942 YP_001460929.1 CDS EcHS_A4387 NC_009800.1 4398667 4399536 R yjeJ; hypothetical protein complement(4398667..4399536) Escherichia coli HS 5592943 YP_001460930.1 CDS EcHS_A4388 NC_009800.1 4399926 4400954 R identified by match to protein family HMM PF04055; match to protein family HMM TIGR00238; KamA family protein complement(4399926..4400954) Escherichia coli HS 5592944 YP_001460931.1 CDS efp NC_009800.1 4400996 4401562 D Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 4400996..4401562 Escherichia coli HS 5593156 YP_001460932.1 CDS ecnB2 NC_009800.1 4401614 4401739 D acts as and antidote to the bacteriolytic entericidin B in the EcnAB toxin-antitoxin complex; entericidin A 4401614..4401739 Escherichia coli HS 5593157 YP_001460933.1 CDS ecnB1 NC_009800.1 4401850 4401996 D identified by similarity to SP:P0ADB7; match to protein family HMM PF08085; entericidin B 4401850..4401996 Escherichia coli HS 5593158 YP_001460934.1 CDS sugE NC_009800.1 4402171 4402488 D member of the SMR family of proton-dependent drug efflux transporters; quaternary ammonium compound efflux pump; confers resistance to cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations; quaternary ammonium compound-resistance protein SugE 4402171..4402488 Escherichia coli HS 5593159 YP_001460935.1 CDS blc NC_009800.1 4402485 4403018 R lipocalin; globomycin-sensitive outer membrane lipoprotein; outer membrane lipoprotein Blc complement(4402485..4403018) Escherichia coli HS 5593542 YP_001460936.1 CDS ampC NC_009800.1 4403107 4404240 R identified by match to protein family HMM PF00144; beta-lactamase complement(4403107..4404240) Escherichia coli HS 5593543 YP_001460937.1 CDS frdD NC_009800.1 4404303 4404662 R in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane; fumarate reductase subunit D complement(4404303..4404662) Escherichia coli HS 5593544 YP_001460938.1 CDS frdC NC_009800.1 4404673 4405068 R part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase subunit C complement(4404673..4405068) Escherichia coli HS 5593545 YP_001460939.1 CDS frdB NC_009800.1 4405079 4405813 R part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase iron-sulfur subunit complement(4405079..4405813) Escherichia coli HS 5594677 YP_001460940.1 CDS frdA NC_009800.1 4405806 4407614 R part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase flavoprotein subunit complement(4405806..4407614) Escherichia coli HS 5594678 YP_001460941.1 CDS genX NC_009800.1 4407939 4408916 D lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase 4407939..4408916 Escherichia coli HS 5594679 YP_001460942.1 CDS EcHS_A4400 NC_009800.1 4409135 4410637 D identified by match to protein family HMM PF00324; amino acid permease 4409135..4410637 Escherichia coli HS 5594680 YP_001460943.1 CDS EcHS_A4401 NC_009800.1 4410788 4414111 R identified by match to protein family HMM PF00924; hypothetical protein complement(4410788..4414111) Escherichia coli HS 5594883 YP_001460944.1 CDS psd NC_009800.1 4414133 4415101 R catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine; phosphatidylserine decarboxylase complement(4414133..4415101) Escherichia coli HS 5594884 YP_001460945.1 CDS rsgA NC_009800.1 4415198 4416250 R EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase complement(4415198..4416250) Escherichia coli HS 5594885 YP_001460946.1 CDS orn NC_009800.1 4416345 4416890 D 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 4416345..4416890 Escherichia coli HS 5594886 YP_001460947.1 CDS EcHS_A4409 NC_009800.1 4417664 4418803 R identified by match to protein family HMM PF00037; match to protein family HMM PF08331; match to protein family HMM TIGR00276; iron-sulfur cluster binding protein complement(4417664..4418803) Escherichia coli HS 5592520 YP_001460948.1 CDS EcHS_A4408 NC_009800.1 4418802 4420349 D identified by match to protein family HMM PF01256; match to protein family HMM PF03853; match to protein family HMM TIGR00196; match to protein family HMM TIGR00197; hypothetical protein 4418802..4420349 Escherichia coli HS 5594085 YP_001460949.1 CDS EcHS_A4410 NC_009800.1 4420321 4420782 D possibly involved in cell wall synthesis; ATPase 4420321..4420782 Escherichia coli HS 5594086 YP_001460950.1 CDS EcHS_A4411 NC_009800.1 4420801 4422138 D identified by match to protein family HMM PF01520; N-acetylmuramoyl-L-alanine amidase 4420801..4422138 Escherichia coli HS 5595091 YP_001460951.1 CDS mutL NC_009800.1 4422148 4423995 D This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 4422148..4423995 Escherichia coli HS 5595092 YP_001460952.1 CDS miaA NC_009800.1 4423988 4424938 D IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 4423988..4424938 Escherichia coli HS 5595093 YP_001460953.1 CDS hfq NC_009800.1 4425024 4425332 D Stimulates the elongation of poly(A) tails; RNA-binding protein Hfq 4425024..4425332 Escherichia coli HS 5595094 YP_001460954.1 CDS hflX NC_009800.1 4425408 4426688 D involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein; GTPase HflX 4425408..4426688 Escherichia coli HS 5593488 YP_001460955.1 CDS hflK NC_009800.1 4426774 4428033 D with HflC inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflK 4426774..4428033 Escherichia coli HS 5593489 YP_001460956.1 CDS hflC NC_009800.1 4428036 4429040 D with HflK inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflC 4428036..4429040 Escherichia coli HS 5593490 YP_001460957.1 CDS EcHS_A4418 NC_009800.1 4429122 4429319 D hypothetical protein 4429122..4429319 Escherichia coli HS 5593491 YP_001460958.1 CDS EcHS_A4419 NC_009800.1 4429292 4429396 R identified by glimmer; hypothetical protein complement(4429292..4429396) Escherichia coli HS 5592709 YP_001460959.1 CDS purA NC_009800.1 4429423 4430721 D catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 4429423..4430721 Escherichia coli HS 5592710 YP_001460960.1 CDS nsrR NC_009800.1 4430926 4431351 D negatively regulates the transcription of genes upregulated by nitrosative stress; transcriptional repressor NsrR 4430926..4431351 Escherichia coli HS 5592711 YP_001460961.1 CDS rnr NC_009800.1 4431390 4433831 D 3'-5'exoribonuclease that acts nonspecifically on poly(A), poly(U) and ribosomal RNAs; exoribonuclease R 4431390..4433831 Escherichia coli HS 5592712 YP_001460962.1 CDS EcHS_A4423 NC_009800.1 4433874 4434011 D identified by glimmer; hypothetical protein 4433874..4434011 Escherichia coli HS 5592192 YP_001460963.1 CDS EcHS_A4424 NC_009800.1 4434011 4434742 D Specifically methylates the ribose of guanosine 2251 in 23S rRNA; 23S rRNA (guanosine-2'-O-)-methyltransferase 4434011..4434742 Escherichia coli HS 5592193 YP_001460964.1 CDS EcHS_A4425 NC_009800.1 4434869 4435270 D identified by similarity to GB:AAL23190.1; hypothetical protein 4434869..4435270 Escherichia coli HS 5592194 YP_001460965.1 CDS EcHS_A4426 NC_009800.1 4435289 4435987 D identified by match to protein family HMM PF04012; PspA/IM30 family protein 4435289..4435987 Escherichia coli HS 5592195 YP_001460966.1 CDS EcHS_A4427 NC_009800.1 4436038 4436697 D hypothetical protein 4436038..4436697 Escherichia coli HS 5592060 YP_001460967.1 CDS EcHS_A4428 NC_009800.1 4436715 4437113 D identified by match to protein family HMM PF03994; inner membrane protein 4436715..4437113 Escherichia coli HS 5592061 YP_001460968.1 CDS EcHS_A4429 NC_009800.1 4437123 4437761 D identified by match to protein family HMM PF06693; hypothetical protein 4437123..4437761 Escherichia coli HS 5592062 YP_001460969.1 CDS EcHS_A4430 NC_009800.1 4437764 4438927 D identified by match to protein family HMM PF03738; glutathionylspermidine synthase domain-containing protein 4437764..4438927 Escherichia coli HS 5592063 YP_001460970.1 CDS EcHS_A4431 NC_009800.1 4439011 4440636 D catalyzes the formation of 3-methylcrotonyl-CoA from isovaleryl-CoA; isovaleryl CoA dehydrogenase 4439011..4440636 Escherichia coli HS 5594254 YP_001460971.1 CDS EcHS_A4432 NC_009800.1 4440753 4441040 R identified by match to protein family HMM PF07338; hypothetical protein complement(4440753..4441040) Escherichia coli HS 5594255 YP_001460972.1 CDS EcHS_A4433 NC_009800.1 4441177 4441605 R identified by similarity to GB:ABB68688.1; match to protein family HMM PF07338; hypothetical protein complement(4441177..4441605) Escherichia coli HS 5594256 YP_001460973.1 CDS EcHS_A4434 NC_009800.1 4441688 4442437 D YjfP; esterase activity towards palmitoyl-CoA and pNP-butyrate in vitro; unknown function and substrate in vivo; esterase 4441688..4442437 Escherichia coli HS 5594257 YP_001460974.1 CDS ulaR NC_009800.1 4442434 4443189 R negative regulator of ulaG and ulaABCDEF; transcriptional repressor UlaR complement(4442434..4443189) Escherichia coli HS 5594315 YP_001460975.1 CDS EcHS_A4436 NC_009800.1 4443297 4444361 R identified by similarity to SP:P39300; L-ascorbate 6-phosphate lactonase complement(4443297..4444361) Escherichia coli HS 5594316 YP_001460976.1 CDS ulaA NC_009800.1 4444716 4446113 D membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; ascorbate-specific PTS system enzyme IIC 4444716..4446113 Escherichia coli HS 5594317 YP_001460977.1 CDS ulaB NC_009800.1 4446129 4446434 D identified by similarity to SP:P69822; match to protein family HMM PF02302; L-ascorbate-specific enzyme IIB component of PTS 4446129..4446434 Escherichia coli HS 5594318 YP_001460978.1 CDS ulaC NC_009800.1 4446444 4446908 D identified by similarity to SP:P69820; match to protein family HMM PF00359; L-ascorbate-specific enzyme IIA component of PTS 4446444..4446908 Escherichia coli HS 5595323 YP_001460979.1 CDS ulaD NC_009800.1 4446922 4447572 D catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase 4446922..4447572 Escherichia coli HS 5595324 YP_001460980.1 CDS ulaE NC_009800.1 4447582 4448436 D UlaE; catalyzes the epimerization of L-ribulose-5-phosphate into L-xylulose-5-phosphate; part of the anaerobic L-ascorbate degradation pathway; L-xylulose 5-phosphate 3-epimerase 4447582..4448436 Escherichia coli HS 5595325 YP_001460981.1 CDS sgaE NC_009800.1 4448436 4449122 D catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 4448436..4449122 Escherichia coli HS 5595326 YP_001460982.1 CDS EcHS_A4443 NC_009800.1 4449251 4449526 R identified by match to protein family HMM PF07338; hypothetical protein complement(4449251..4449526) Escherichia coli HS 5591345 YP_001460983.1 CDS rpsF NC_009800.1 4449853 4450248 D binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 4449853..4450248 Escherichia coli HS 5591346 YP_001460984.1 CDS priB NC_009800.1 4450255 4450569 D binds single-stranded DNA at the primosome assembly site; primosomal replication protein N 4450255..4450569 Escherichia coli HS 5591347 YP_001460985.1 CDS rpsR NC_009800.1 4450574 4450801 D binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 4450574..4450801 Escherichia coli HS 5591348 YP_001460986.1 CDS rplI NC_009800.1 4450843 4451292 D in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 4450843..4451292 Escherichia coli HS 5592381 YP_001460987.1 CDS EcHS_A4448 NC_009800.1 4451404 4452375 R identified by match to protein family HMM PF03480; match to protein family HMM TIGR00787; TRAP transporter solute receptor DctP family protein complement(4451404..4452375) Escherichia coli HS 5592382 YP_001460988.1 CDS EcHS_A4449 NC_009800.1 4452428 4453729 R identified by match to protein family HMM PF06808; match to protein family HMM TIGR00786; TRAP transporter DctM subunit complement(4452428..4453729) Escherichia coli HS 5592383 YP_001460989.1 CDS EcHS_A4450 NC_009800.1 4454269 4456350 R identified by match to protein family HMM PF00890; match to protein family HMM PF01266; match to protein family HMM PF07992; pyridine nucleotide-disulfide oxidoreductase complement(4454269..4456350) Escherichia coli HS 5592384 YP_001460990.1 CDS EcHS_A4451 NC_009800.1 4456347 4457888 R identified by match to protein family HMM PF01144; CoA-transferase complement(4456347..4457888) Escherichia coli HS 5592350 YP_001460991.1 CDS EcHS_A4452 NC_009800.1 4457898 4458674 R identified by match to protein family HMM PF00378; enoyl-CoA hydratase complement(4457898..4458674) Escherichia coli HS 5592351 YP_001460992.1 CDS EcHS_A4453 NC_009800.1 4458684 4459526 R identified by match to protein family HMM PF01261; AP endonuclease complement(4458684..4459526) Escherichia coli HS 5592352 YP_001460993.1 CDS EcHS_A4454 NC_009800.1 4459536 4460327 R catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase complement(4459536..4460327) Escherichia coli HS 5592353 YP_001460994.1 CDS EcHS_A4455 NC_009800.1 4460540 4461187 D identified by match to protein family HMM PF00440; TetR family transcriptional regulator 4460540..4461187 Escherichia coli HS 5592847 YP_001460995.1 CDS EcHS_A4456 NC_009800.1 4461171 4461809 R identified by similarity to SP:P44415; match to protein family HMM PF04225; match to protein family HMM PF08525; opacity-associated family protein complement(4461171..4461809) Escherichia coli HS 5592848 YP_001460996.1 CDS fklB NC_009800.1 4462028 4462648 D FKBP-type; rotamase; catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; peptidyl-prolyl cis-trans isomerase 4462028..4462648 Escherichia coli HS 5592849 YP_001460997.1 CDS cycA NC_009800.1 4462957 4464360 D involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine; D-alanine/D-serine/glycine permease 4462957..4464360 Escherichia coli HS 5592850 YP_001460998.1 CDS EcHS_A4460 NC_009800.1 4464366 4464515 R identified by glimmer; hypothetical protein complement(4464366..4464515) Escherichia coli HS 5593510 YP_001460999.1 CDS EcHS_A4459 NC_009800.1 4464627 4465061 D exported protein-like; hypothetical protein 4464627..4465061 Escherichia coli HS 5593511 YP_001461000.1 CDS EcHS_A4461 NC_009800.1 4465295 4466227 D identified by glimmer; hypothetical protein 4465295..4466227 Escherichia coli HS 5593512 YP_001461001.1 CDS EcHS_A4462 NC_009800.1 4466212 4466304 D identified by glimmer; hypothetical protein 4466212..4466304 Escherichia coli HS 5593513 YP_001461002.1 CDS EcHS_A4463 NC_009800.1 4466474 4467136 R Involved in anaerobic NO protection and iron metabolism; iron-sulfur cluster repair di-iron protein complement(4466474..4467136) Escherichia coli HS 5594154 YP_001461003.1 CDS EcHS_A4464 NC_009800.1 4467244 4468209 R identified by similarity to SP:P39314; match to protein family HMM PF00892; hypothetical protein complement(4467244..4468209) Escherichia coli HS 5594155 YP_001461004.1 CDS EcHS_A4466 NC_009800.1 4468317 4469177 R identified by match to protein family HMM PF01073; match to protein family HMM PF05368; NmrA family protein complement(4468317..4469177) Escherichia coli HS 5594156 YP_001461005.1 CDS EcHS_A4465 NC_009800.1 4469266 4469646 D identified by match to protein family HMM PF01638; transcriptional regulator 4469266..4469646 Escherichia coli HS 5594157 YP_001461006.1 CDS cpdB NC_009800.1 4469775 4471718 R periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate; bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein complement(4469775..4471718) Escherichia coli HS 5594053 YP_001461007.1 CDS cysQ NC_009800.1 4471908 4472648 D catalyzes the formation of AMP from adenosine-3',5'-bisphosphate; adenosine-3'(2'),5'-bisphosphate nucleotidase 4471908..4472648 Escherichia coli HS 5594054 YP_001461008.1 CDS EcHS_A4469 NC_009800.1 4472638 4473195 R identified by match to protein family HMM TIGR01626; hypothetical protein complement(4472638..4473195) Escherichia coli HS 5594055 YP_001461009.1 CDS EcHS_A4470 NC_009800.1 4473520 4473726 D identified by match to protein family HMM PF06526; hypothetical protein 4473520..4473726 Escherichia coli HS 5594056 YP_001461010.1 CDS EcHS_A4471 NC_009800.1 4473788 4475131 R identified by match to protein family HMM PF00571; match to protein family HMM PF01595; match to protein family HMM PF03471; transporter complement(4473788..4475131) Escherichia coli HS 5594285 YP_001461011.1 CDS EcHS_A4472 NC_009800.1 4475527 4476507 D identified by match to protein family HMM PF01548; match to protein family HMM PF02371; IS621, transposase 4475527..4476507 Escherichia coli HS 5594286 YP_001461012.1 CDS msrA NC_009800.1 4476733 4477371 R this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A complement(4476733..4477371) Escherichia coli HS 5594287 YP_001461013.1 CDS EcHS_A4474 NC_009800.1 4477577 4479310 D ytfM; identified by match to protein family HMM PF01103; match to protein family HMM PF07244; OMP85 family outer membrane protein 4477577..4479310 Escherichia coli HS 5594288 YP_001461014.1 CDS EcHS_A4475 NC_009800.1 4479307 4483086 D ytfN; identified by match to protein family HMM PF04357; hypothetical protein 4479307..4483086 Escherichia coli HS 5594926 YP_001461015.1 CDS EcHS_A4476 NC_009800.1 4483089 4483430 D ytfP; identified by match to protein family HMM PF03674; hypothetical protein 4483089..4483430 Escherichia coli HS 5594927 YP_001461016.1 CDS chpS NC_009800.1 4483642 4483893 D part of the toxin-antitoxin ChpB-ChpS system; antitoxin ChpS 4483642..4483893 Escherichia coli HS 5594928 YP_001461017.1 CDS chpB NC_009800.1 4483887 4484237 D toxin of the ChpB-ChpS toxin-antitoxin system; toxin ChpB 4483887..4484237 Escherichia coli HS 5594929 YP_001461018.1 CDS ppa NC_009800.1 4484317 4484847 R catalyzes the hydrolysis of pyrophosphate to phosphate; inorganic pyrophosphatase complement(4484317..4484847) Escherichia coli HS 5593897 YP_001461019.1 CDS EcHS_A4480 NC_009800.1 4484859 4484984 R identified by similarity to GB:AAN83745.1; hypothetical protein complement(4484859..4484984) Escherichia coli HS 5593898 YP_001461020.1 CDS EcHS_A4481 NC_009800.1 4485157 4486113 D identified by match to protein family HMM PF00532; sugar ABC transporter periplasmic sugar-binding protein 4485157..4486113 Escherichia coli HS 5593899 YP_001461021.1 CDS EcHS_A4482 NC_009800.1 4486253 4487755 D identified by match to protein family HMM PF00005; sugar ABC transporter ATP-binding protein 4486253..4487755 Escherichia coli HS 5593900 YP_001461022.1 CDS EcHS_A4483 NC_009800.1 4487766 4488791 D identified by match to protein family HMM PF02653; sugar ABC transporter permease 4487766..4488791 Escherichia coli HS 5595161 YP_001461023.1 CDS EcHS_A4484 NC_009800.1 4488778 4489773 D membrane component of a sugar ABC transporter system; ABC transporter permease 4488778..4489773 Escherichia coli HS 5595162 YP_001461024.1 CDS fbp NC_009800.1 4489806 4490804 R catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate; fructose-1,6-bisphosphatase complement(4489806..4490804) Escherichia coli HS 5595163 YP_001461025.1 CDS mpl NC_009800.1 4490980 4492353 D identified by similarity to SP:P37773; match to protein family HMM PF01225; match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01081; UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelat e ligase 4490980..4492353 Escherichia coli HS 5595164 YP_001461026.1 CDS yjgA NC_009800.1 4492504 4493055 R identified by match to protein family HMM PF04751; hypothetical protein complement(4492504..4493055) Escherichia coli HS 5593327 YP_001461027.1 CDS pmbA NC_009800.1 4493161 4494501 D protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD; peptidase PmbA 4493161..4494501 Escherichia coli HS 5593328 YP_001461028.1 CDS cybC NC_009800.1 4494684 4495070 D identified by similarity to SP:P0ABE7; match to protein family HMM PF07361; soluble cytochrome b562 4494684..4495070 Escherichia coli HS 5593329 YP_001461029.1 CDS nrdG NC_009800.1 4495115 4495579 R activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions; anaerobic ribonucleotide reductase-activating protein complement(4495115..4495579) Escherichia coli HS 5593330 YP_001461030.1 CDS EcHS_A4491 NC_009800.1 4495579 4495677 R identified by glimmer; hypothetical protein complement(4495579..4495677) Escherichia coli HS 5593310 YP_001461031.1 CDS nrdD NC_009800.1 4495737 4497875 R Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase complement(4495737..4497875) Escherichia coli HS 5593311 YP_001461032.1 CDS treC NC_009800.1 4498269 4499924 R identified by match to protein family HMM PF00128; match to protein family HMM TIGR02403; trehalose-6-phosphate hydrolase complement(4498269..4499924) Escherichia coli HS 5593312 YP_001461033.1 CDS treB NC_009800.1 4499974 4501392 R phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; trehalose(maltose)-specific PTS system components IIBC complement(4499974..4501392) Escherichia coli HS 5593313 YP_001461034.1 CDS treR NC_009800.1 4501514 4502461 R regulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon; trehalose repressor complement(4501514..4502461) Escherichia coli HS 5591823 YP_001461035.1 CDS EcHS_A4496 NC_009800.1 4502511 4502699 D NULL; identified by glimmer; hypothetical protein 4502511..4502699 Escherichia coli HS 5591824 YP_001461036.1 CDS mgtA NC_009800.1 4502840 4505536 D P-type ATPase involved in magnesium influx; magnesium-transporting ATPase MgtA 4502840..4505536 Escherichia coli HS 5591825 YP_001461037.1 CDS EcHS_A4498 NC_009800.1 4505764 4506744 R identified by match to protein family HMM PF01548; match to protein family HMM PF02371; IS621, transposase complement(4505764..4506744) Escherichia coli HS 5591826 YP_001461038.1 CDS EcHS_A4499 NC_009800.1 4507021 4507407 R identified by match to protein family HMM PF01042; match to protein family HMM TIGR00004; endoribonuclease L-PSP complement(4507021..4507407) Escherichia coli HS 5591834 YP_001461039.1 CDS pyrI NC_009800.1 4507480 4507941 R involved in the allosteric regulation of aspartate carbamoyltransferase; aspartate carbamoyltransferase complement(4507480..4507941) Escherichia coli HS 5591835 YP_001461040.1 CDS pyrB NC_009800.1 4507954 4508889 R catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase complement(4507954..4508889) Escherichia coli HS 5591836 YP_001461041.1 CDS pyrL NC_009800.1 4508893 4509027 R identified by match to protein family HMM PF08052; pyrBI operon leader peptide complement(4508893..4509027) Escherichia coli HS 5591837 YP_001461042.1 CDS EcHS_A4503 NC_009800.1 4509066 4509203 R identified by glimmer; hypothetical protein complement(4509066..4509203) Escherichia coli HS 5593617 YP_001461043.1 CDS EcHS_A4504 NC_009800.1 4509308 4509703 R identified by match to protein family HMM PF01042; endoribonuclease L-PSP complement(4509308..4509703) Escherichia coli HS 5593618 YP_001461044.1 CDS EcHS_A4505 NC_009800.1 4509834 4510547 R identified by match to protein family HMM PF00106; oxidoreductase complement(4509834..4510547) Escherichia coli HS 5593619 YP_001461045.1 CDS EcHS_A4506 NC_009800.1 4510618 4511211 D yjgJ; identified by match to protein family HMM PF00440; TetR family transcriptional regulator 4510618..4511211 Escherichia coli HS 5593620 YP_001461046.1 CDS EcHS_A4507 NC_009800.1 4511356 4511808 D yjgK; identified by similarity to GB:CAD06928.1; match to protein family HMM PF04074; match to protein family HMM TIGR00022; hypothetical protein 4511356..4511808 Escherichia coli HS 5591772 YP_001461047.1 CDS argF NC_009800.1 4513591 4514595 R catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; E. coli K12 has two genes, argF and argI, capable of producing functional ornithine carbamoyltransferase. When both are active in the same cell, the two gene products form a family of four hybrid trimeric isoenzymes designated, FFF, FFI, FII, and III.; ornithine carbamoyltransferase subunit I complement(4513591..4514595) Escherichia coli HS 5591775 YP_001461048.1 CDS EcHS_A4511 NC_009800.1 4514757 4515173 D yjgD; identified by similarity to PDB:1NXI_A; match to protein family HMM PF06877; hypothetical protein 4514757..4515173 Escherichia coli HS 5593016 YP_001461049.1 CDS EcHS_A4512 NC_009800.1 4515219 4515722 R NULL; identified by match to protein family HMM PF00583; acetyltransferase complement(4515219..4515722) Escherichia coli HS 5593017 YP_001461050.1 CDS EcHS_A4513 NC_009800.1 4515915 4517111 D yjgN; identified by match to protein family HMM PF05987; hypothetical protein 4515915..4517111 Escherichia coli HS 5593018 YP_001461051.1 CDS valS NC_009800.1 4517167 4520022 R valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase complement(4517167..4520022) Escherichia coli HS 5593019 YP_001461052.1 CDS holC NC_009800.1 4520022 4520465 R binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit chi complement(4520022..4520465) Escherichia coli HS 5593273 YP_001461053.1 CDS pepA NC_009800.1 4520599 4522110 R catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase complement(4520599..4522110) Escherichia coli HS 5593274 YP_001461054.1 CDS EcHS_A4517 NC_009800.1 4522377 4523477 D yjgP; identified by match to protein family HMM PF03739; permease 4522377..4523477 Escherichia coli HS 5593275 YP_001461055.1 CDS EcHS_A4518 NC_009800.1 4523477 4524559 D yjgQ; identified by match to protein family HMM PF03739; permease 4523477..4524559 Escherichia coli HS 5593276 YP_001461056.1 CDS EcHS_A4519 NC_009800.1 4524687 4526189 R yjgR; identified by match to protein family HMM PF05872; hypothetical protein complement(4524687..4526189) Escherichia coli HS 5593982 YP_001461057.1 CDS idnR NC_009800.1 4526267 4527265 R identified by similarity to SP:P39343; match to protein family HMM PF00356; match to protein family HMM PF00532; transcriptional regulator IdnR complement(4526267..4527265) Escherichia coli HS 5593983 YP_001461058.1 CDS idnT NC_009800.1 4527332 4528651 R identified by similarity to SP:P39344; match to protein family HMM PF02447; match to protein family HMM PF03600; match to protein family HMM PF06808; match to protein family HMM TIGR00791; Gnt-II system L-idonate transporter complement(4527332..4528651) Escherichia coli HS 5593984 YP_001461059.1 CDS idnO NC_009800.1 4528716 4529480 R Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate; gluconate 5-dehydrogenase complement(4528716..4529480) Escherichia coli HS 5593985 YP_001461060.1 CDS idnD NC_009800.1 4529504 4530535 R NAD-binding; L-idonate 5-dehydrogenase complement(4529504..4530535) Escherichia coli HS 5591567 YP_001461061.1 CDS idnK NC_009800.1 4530752 4531315 D identified by similarity to SP:P39208; match to protein family HMM PF01202; match to protein family HMM TIGR01313; D-gluconate kinase 4530752..4531315 Escherichia coli HS 5591568 YP_001461062.1 CDS EcHS_A4525 NC_009800.1 4531319 4532338 R identified by match to protein family HMM PF00107; match to protein family HMM PF08240; zinc-binding dehydrogenase oxidoreductase complement(4531319..4532338) Escherichia coli HS 5591569 YP_001461063.1 CDS EcHS_A4527 NC_009800.1 4532707 4534656 D identified by match to protein family HMM PF00589; phage integrase site specific recombinase 4532707..4534656 Escherichia coli HS 5592199 YP_001461064.1 CDS EcHS_A4528 NC_009800.1 4534995 4536170 R identified by glimmer; hypothetical protein complement(4534995..4536170) Escherichia coli HS 5592200 YP_001461065.1 CDS EcHS_A4529 NC_009800.1 4536300 4537112 R identified by similarity to GB:AAP17067.1; match to protein family HMM PF00665; ISEhe3, transposase orfB complement(4536300..4537112) Escherichia coli HS 5592201 YP_001461066.1 CDS EcHS_A4530 NC_009800.1 4537169 4537447 R identified by match to protein family HMM PF01527; ISEhe3, transposase orfA complement(4537169..4537447) Escherichia coli HS 5594338 YP_001461067.1 CDS EcHS_A4531 NC_009800.1 4537492 4538295 R hypothetical protein complement(4537492..4538295) Escherichia coli HS 5594339 YP_001461068.1 CDS EcHS_A4532 NC_009800.1 4538288 4540363 R identified by match to protein family HMM PF07728; ATPase complement(4538288..4540363) Escherichia coli HS 5594340 YP_001461069.1 CDS EcHS_A4533 NC_009800.1 4540533 4541405 R hypothetical protein complement(4540533..4541405) Escherichia coli HS 5594341 YP_001461070.1 CDS EcHS_A4534 NC_009800.1 4541617 4542597 R yjhS; identified by match to protein family HMM PF03629; hypothetical protein complement(4541617..4542597) Escherichia coli HS 5594049 YP_001461071.1 CDS EcHS_A4535 NC_009800.1 4542662 4543768 R yjhT; identified by match to protein family HMM PF01344; match to protein family HMM PF07646; kelch repeat-containing protein complement(4542662..4543768) Escherichia coli HS 5594050 YP_001461072.1 CDS EcHS_A4536 NC_009800.1 4543788 4544504 R yjhA; identified by match to protein family HMM PF06178; oligogalacturonate-specific porin protein (KdgM) complement(4543788..4544504) Escherichia coli HS 5594051 YP_001461073.1 CDS EcHS_A4537 NC_009800.1 4545170 4545307 R identified by glimmer; hypothetical protein complement(4545170..4545307) Escherichia coli HS 5594052 YP_001461074.1 CDS fimB NC_009800.1 4545960 4546562 D inversion of on/off regulator of fimA; tyrosine recombinase 4545960..4546562 Escherichia coli HS 5593503 YP_001461075.1 CDS fimE NC_009800.1 4547040 4547636 D inversion of on/off regulator of fimA; tyrosine recombinase 4547040..4547636 Escherichia coli HS 5593504 YP_001461076.1 CDS EcHS_A4540 NC_009800.1 4548117 4548671 D identified by similarity to SP:P04128; match to protein family HMM PF00419; type-1 fimbrial protein 4548117..4548671 Escherichia coli HS 5593505 YP_001461077.1 CDS EcHS_A4541 NC_009800.1 4548736 4549275 D identified by similarity to SP:P04128; match to protein family HMM PF00419; type-1 fimbrial protein 4548736..4549275 Escherichia coli HS 5593506 YP_001461078.1 CDS fimC NC_009800.1 4549312 4550037 D identified by match to protein family HMM PF00345; match to protein family HMM PF02753; chaperone protein FimC 4549312..4550037 Escherichia coli HS 5594247 YP_001461079.1 CDS fimD1 NC_009800.1 4550149 4552740 D identified by similarity to SP:P30130; match to protein family HMM PF00577; outer membrane usher protein fimD 4550149..4552740 Escherichia coli HS 5594248 YP_001461080.1 CDS fimF NC_009800.1 4552750 4553280 D identified by similarity to SP:P08189; match to protein family HMM PF00419; fimbrial protein FimF 4552750..4553280 Escherichia coli HS 5594249 YP_001461081.1 CDS fimG NC_009800.1 4553293 4553796 D identified by similarity to SP:P08190; match to protein family HMM PF00419; protein fimG 4553293..4553796 Escherichia coli HS 5594250 YP_001461082.1 CDS fimH NC_009800.1 4553816 4554718 D identified by match to protein family HMM PF00419; match to protein family HMM PF09160; protein FimH 4553816..4554718 Escherichia coli HS 5591791 YP_001461083.1 CDS gntP NC_009800.1 4554961 4556304 R identified by similarity to SP:P0AC94; match to protein family HMM PF02447; match to protein family HMM PF03600; match to protein family HMM TIGR00791; fructuronate transporter complement(4554961..4556304) Escherichia coli HS 5591792 YP_001461084.1 CDS uxuA NC_009800.1 4556644 4557828 D catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate; mannonate dehydratase 4556644..4557828 Escherichia coli HS 5591793 YP_001461085.1 CDS EcHS_A4549 NC_009800.1 4557909 4559369 D identified by match to protein family HMM PF01232; match to protein family HMM PF08125; mannitol dehydrogenase 4557909..4559369 Escherichia coli HS 5591794 YP_001461086.1 CDS EcHS_A4551 NC_009800.1 4559391 4559585 R identified by glimmer; hypothetical protein complement(4559391..4559585) Escherichia coli HS 5595396 YP_001461087.1 CDS EcHS_A4550 NC_009800.1 4559584 4560357 D regulates the expression of uxuBA; DNA-binding transcriptional repressor UxuR 4559584..4560357 Escherichia coli HS 5595397 YP_001461088.1 CDS EcHS_A4552 NC_009800.1 4560498 4561328 R yjiC; identified by similarity to GB:ABB68791.1; hypothetical protein complement(4560498..4561328) Escherichia coli HS 5595398 YP_001461089.1 CDS EcHS_A4553 NC_009800.1 4561662 4561805 D identified by glimmer; hypothetical protein 4561662..4561805 Escherichia coli HS 5595399 YP_001461090.1 CDS EcHS_A4554 NC_009800.1 4561992 4562393 D yjiD; identified by similarity to GB:AAL22004.1; match to protein family HMM PF04965; hypothetical protein 4561992..4562393 Escherichia coli HS 5594435 YP_001461091.1 CDS EcHS_A4555 NC_009800.1 4562386 4563297 R identified by match to protein family HMM PF00126; match to protein family HMM PF03466; DNA-binding transcriptional regulator complement(4562386..4563297) Escherichia coli HS 5594436 YP_001461092.1 CDS iadA NC_009800.1 4563362 4564534 R identified by similarity to SP:P39377; match to protein family HMM PF01979; match to protein family HMM PF07969; match to protein family HMM TIGR01975; isoaspartyl dipeptidase complement(4563362..4564534) Escherichia coli HS 5594437 YP_001461093.1 CDS EcHS_A4557 NC_009800.1 4564547 4565008 R yjiG; identified by match to protein family HMM PF07670; hypothetical protein complement(4564547..4565008) Escherichia coli HS 5594438 YP_001461094.1 CDS EcHS_A4558 NC_009800.1 4565005 4565688 R identified by match to protein family HMM PF07670; transporter complement(4565005..4565688) Escherichia coli HS 5592156 YP_001461095.1 CDS kptA NC_009800.1 4565938 4566492 D in yeast cells this enzyme removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate; functions in tRNA splicing; the function and substrate of bacterial enzymes in organisms that do not perform splicing is unknown; RNA 2'-phosphotransferase-like protein 4565938..4566492 Escherichia coli HS 5592157 YP_001461096.1 CDS EcHS_A4560 NC_009800.1 4566505 4567683 R identified by match to protein family HMM PF06779; match to protein family HMM PF07690; major facilitator transporter complement(4566505..4567683) Escherichia coli HS 5592158 YP_001461097.1 CDS EcHS_A4561 NC_009800.1 4567751 4568722 R yjiK; identified by match to protein family HMM PF06977; hypothetical protein complement(4567751..4568722) Escherichia coli HS 5592159 YP_001461098.1 CDS hgdC NC_009800.1 4568930 4569697 R identified by similarity to SP:P11568; match to protein family HMM PF01869; match to protein family HMM TIGR00241; (R)-2-hydroxyglutaryl-CoA dehydratase activator complement(4568930..4569697) Escherichia coli HS 5595310 YP_001461099.1 CDS EcHS_A4563 NC_009800.1 4569707 4570858 R yjiM; identified by match to protein family HMM PF06050; 2-hydroxyglutaryl-CoA dehydratase, D-component complement(4569707..4570858) Escherichia coli HS 5595311 YP_001461100.1 CDS EcHS_A4564 NC_009800.1 4570974 4572254 R yjiN; identified by match to protein family HMM PF04286; hypothetical protein complement(4570974..4572254) Escherichia coli HS 5595312 YP_001461101.1 CDS mdtM NC_009800.1 4572295 4573527 R identified by similarity to SP:P39386; match to protein family HMM PF07690; multidrug resistance protein MdtM complement(4572295..4573527) Escherichia coli HS 5595313 YP_001461102.1 CDS EcHS_A4566 NC_009800.1 4573994 4574938 D yjiP; identified by match to protein family HMM PF04754; match to protein family HMM TIGR01784; hypothetical protein 4573994..4574938 Escherichia coli HS 5594538 YP_001461103.1 CDS EcHS_A4567 NC_009800.1 4575009 4575125 R identified by glimmer; hypothetical protein complement(4575009..4575125) Escherichia coli HS 5594539 YP_001461104.1 CDS EcHS_A4568 NC_009800.1 4575180 4576592 R identified by match to protein family HMM PF00155; match to protein family HMM PF00392; GntR family transcriptional regulator complement(4575180..4576592) Escherichia coli HS 5594540 YP_001461105.1 CDS EcHS_A4569 NC_009800.1 4576769 4576933 D yjiS; identified by similarity to GB:BAB38726.1; match to protein family HMM PF06568; hypothetical protein 4576769..4576933 Escherichia coli HS 5594541 YP_001461106.1 CDS EcHS_A4572 NC_009800.1 4579902 4580858 R NULL; identified by match to protein family HMM PF02492; match to protein family HMM PF07683; GTP-binding protein YjiA complement(4579902..4580858) Escherichia coli HS 5593390 YP_001461107.1 CDS EcHS_A4573 NC_009800.1 4580869 4581072 R yjiX; identified by similarity to SP:P0ADD1; match to protein family HMM PF04328; hypothetical protein complement(4580869..4581072) Escherichia coli HS 5593391 YP_001461108.1 CDS EcHS_A4574 NC_009800.1 4581121 4583286 R identified by match to protein family HMM PF02554; carbon starvation family protein complement(4581121..4583286) Escherichia coli HS 5593392 YP_001461109.1 CDS hpaC NC_009800.1 4583664 4584176 R identified by similarity to SP:Q57501; match to protein family HMM PF01613; match to protein family HMM TIGR02296; 4-hydroxyphenylacetate 3-monooxygenase, reductase component complement(4583664..4584176) Escherichia coli HS 5595196 YP_001461110.1 CDS hpaB NC_009800.1 4584194 4585756 R identified by similarity to SP:Q57160; match to protein family HMM PF03241; match to protein family HMM TIGR02310; 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component complement(4584194..4585756) Escherichia coli HS 5595197 YP_001461111.1 CDS hpaA NC_009800.1 4586007 4586897 R identified by match to protein family HMM PF00165; match to protein family HMM PF07883; match to protein family HMM TIGR02297; 4-hydroxyphenylacetate catabolism regulatory protein HpaA complement(4586007..4586897) Escherichia coli HS 5595198 YP_001461112.1 CDS hpaX NC_009800.1 4586907 4588283 R identified by match to protein family HMM PF07690; match to protein family HMM TIGR02332; 4-hydroxyphenylacetate permease complement(4586907..4588283) Escherichia coli HS 5595199 YP_001461113.1 CDS hpaI NC_009800.1 4588406 4589194 R identified by match to protein family HMM PF03328; match to protein family HMM TIGR02311; 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase complement(4588406..4589194) Escherichia coli HS 5592865 YP_001461114.1 CDS hpaH NC_009800.1 4589205 4590008 R identified by match to protein family HMM PF01689; match to protein family HMM TIGR02312; 2-oxo-hepta-3-ene-1,7-dioic acid hydratase complement(4589205..4590008) Escherichia coli HS 5592866 YP_001461115.1 CDS hpcD NC_009800.1 4590119 4590499 R identified by similarity to SP:Q05354; match to protein family HMM PF02962; 5-carboxymethyl-2-hydroxymuconate delta-isomerase complement(4590119..4590499) Escherichia coli HS 5592867 YP_001461116.1 CDS hpaD NC_009800.1 4590509 4591360 R identified by match to protein family HMM PF02900; match to protein family HMM TIGR02298; 3,4-dihydroxyphenylacetate 2,3-dioxygenase complement(4590509..4591360) Escherichia coli HS 5592868 YP_001461117.1 CDS hpaE NC_009800.1 4591362 4592828 R identified by match to protein family HMM PF00171; match to protein family HMM TIGR02299; 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase complement(4591362..4592828) Escherichia coli HS 5591184 YP_001461118.1 CDS hpaG NC_009800.1 4592825 4594114 R identified by match to protein family HMM PF01557; match to protein family HMM TIGR02303; match to protein family HMM TIGR02305; 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase complement(4592825..4594114) Escherichia coli HS 5591185 YP_001461119.1 CDS hpaR NC_009800.1 4594386 4594832 D identified by match to protein family HMM PF01047; match to protein family HMM TIGR02337; homoprotocatechuate degradation operon regulator, HpaR 4594386..4594832 Escherichia coli HS 5591186 YP_001461120.1 CDS tsr NC_009800.1 4594951 4596624 D identified by match to protein family HMM PF00015; match to protein family HMM PF00672; match to protein family HMM PF02203; methyl-accepting chemotaxis protein I 4594951..4596624 Escherichia coli HS 5591187 YP_001461121.1 CDS EcHS_A4587 NC_009800.1 4596673 4598034 R identified by match to protein family HMM PF07690; major facilitator transporter complement(4596673..4598034) Escherichia coli HS 5594711 YP_001461122.1 CDS EcHS_A4588 NC_009800.1 4598249 4599163 R yjjM; identified by match to protein family HMM PF07729; GntR family transcriptional regulator complement(4598249..4599163) Escherichia coli HS 5594712 YP_001461123.1 CDS EcHS_A4589 NC_009800.1 4599176 4599268 D identified by glimmer; hypothetical protein 4599176..4599268 Escherichia coli HS 5594713 YP_001461124.1 CDS EcHS_A4590 NC_009800.1 4599302 4600324 D identified by match to protein family HMM PF00107; match to protein family HMM PF08240; zinc-binding dehydrogenase oxidoreductase 4599302..4600324 Escherichia coli HS 5594714 YP_001461125.1 CDS mdoB NC_009800.1 4600464 4602755 R catalyzes the transfer of phosphoglycerol to the glucan backbone; phosphoglycerol transferase I complement(4600464..4602755) Escherichia coli HS 5594455 YP_001461126.1 CDS EcHS_A4592 NC_009800.1 4603009 4603506 R identified by similarity to GB:AAZ90979.1; hypothetical protein complement(4603009..4603506) Escherichia coli HS 5594456 YP_001461127.1 CDS dnaC NC_009800.1 4603552 4604289 R acts to load the DnaB helicase onto the initiation site during DNA replication; DNA replication protein DnaC complement(4603552..4604289) Escherichia coli HS 5594457 YP_001461128.1 CDS dnaT NC_009800.1 4604292 4604831 R This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'; primosomal protein DnaI complement(4604292..4604831) Escherichia coli HS 5594458 YP_001461129.2 CDS EcHS_A4595 NC_009800.1 4604939 4605412 R yjjB; hypothetical protein complement(4604939..4605412) Escherichia coli HS 5592830 YP_001461130.1 CDS EcHS_A4596 NC_009800.1 4605403 4606236 R identified by match to protein family HMM PF06738; hypothetical protein complement(4605403..4606236) Escherichia coli HS 5592831 YP_001461131.1 CDS EcHS_A4597 NC_009800.1 4606397 4606489 R identified by glimmer; hypothetical protein complement(4606397..4606489) Escherichia coli HS 5592832 YP_001461132.1 CDS EcHS_A4598 NC_009800.1 4606792 4607517 D identified by match to protein family HMM PF00196; LuxR family transcriptional regulator 4606792..4607517 Escherichia coli HS 5592833 YP_001461133.1 CDS EcHS_A4599 NC_009800.1 4607475 4608152 D regulator for the transport and utilization of the aromatic beta-glucosides arbutin and silicin; DNA-binding transcriptional activator BglJ 4607475..4608152 Escherichia coli HS 5593408 YP_001461134.1 CDS fhuF NC_009800.1 4608190 4608978 R identified by similarity to SP:P39405; match to protein family HMM PF06276; ferric iron reductase involved in ferric hydroximate transport complement(4608190..4608978) Escherichia coli HS 5593409 YP_001461135.1 CDS EcHS_A4601 NC_009800.1 4609008 4609355 D identified by similarity to GB:AAN83867.1; match to protein family HMM PF07256; hypothetical protein 4609008..4609355 Escherichia coli HS 5593410 YP_001461136.1 CDS rsmC NC_009800.1 4609984 4611015 R 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit; 16S ribosomal RNA m2G1207 methyltransferase complement(4609984..4611015) Escherichia coli HS 5594080 YP_001461137.1 CDS holD NC_009800.1 4611118 4611531 D with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit psi 4611118..4611531 Escherichia coli HS 5594081 YP_001461138.1 CDS rimI NC_009800.1 4611500 4611946 D alanine acetyltransferase that specifically acetylates ribosomal protein S18; ribosomal-protein-alanine N-acetyltransferase 4611500..4611946 Escherichia coli HS 5594919 YP_001461139.1 CDS yjjG NC_009800.1 4611961 4612638 D manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily; nucleotidase 4611961..4612638 Escherichia coli HS 5594920 YP_001461140.1 CDS prfC NC_009800.1 4612729 4614318 D stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 4612729..4614318 Escherichia coli HS 5594921 YP_001461141.1 CDS osmY NC_009800.1 4614711 4615316 D identified by similarity to SP:P27291; match to protein family HMM PF04972; periplasmic protein 4614711..4615316 Escherichia coli HS 5594922 YP_001461142.1 CDS EcHS_A4611 NC_009800.1 4615443 4615604 D identified by glimmer; hypothetical protein 4615443..4615604 Escherichia coli HS 5593823 YP_001461143.1 CDS EcHS_A4612 NC_009800.1 4615726 4616799 D yjjU; identified by match to protein family HMM PF01734; patatin family phospholipase 4615726..4616799 Escherichia coli HS 5593824 YP_001461144.1 CDS EcHS_A4613 NC_009800.1 4616796 4617578 D identified by match to protein family HMM PF01026; deoxyribonuclease YjjV 4616796..4617578 Escherichia coli HS 5593825 YP_001461145.1 CDS EcHS_A4614 NC_009800.1 4617691 4618554 R identified by match to protein family HMM PF00037; match to protein family HMM PF04055; radical SAM domain-containing protein complement(4617691..4618554) Escherichia coli HS 5593826 YP_001461146.1 CDS EcHS_A4615 NC_009800.1 4618526 4620076 R yjjI; hypothetical protein complement(4618526..4620076) Escherichia coli HS 5593923 YP_001461147.1 CDS deoC NC_009800.1 4620334 4621113 D catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 4620334..4621113 Escherichia coli HS 5593924 YP_001461148.1 CDS deoA NC_009800.1 4621240 4622562 D Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate; thymidine phosphorylase 4621240..4622562 Escherichia coli HS 5593925 YP_001461149.1 CDS deoB NC_009800.1 4622614 4623837 D catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 4622614..4623837 Escherichia coli HS 5593926 YP_001461150.1 CDS deoD NC_009800.1 4623917 4624636 D catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 4623917..4624636 Escherichia coli HS 5592417 YP_001461151.1 CDS lplA NC_009800.1 4625092 4626108 R Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl on the lipoate-dependent enzymes. Creates an amide linkage that joins the free carboxyl group of lipoic acid to the epsilon-amino group of a specific lysine residue in lipoyl domain of apoproteins; lipoate-protein ligase A complement(4625092..4626108) Escherichia coli HS 5592419 YP_001461152.1 CDS EcHS_A4622 NC_009800.1 4626136 4626780 R hypothetical protein complement(4626136..4626780) Escherichia coli HS 5592420 YP_001461153.1 CDS serB NC_009800.1 4626886 4627854 D catalyzes the formation of serine from O-phosphoserine; phosphoserine phosphatase 4626886..4627854 Escherichia coli HS 5593964 YP_001461154.1 CDS radA NC_009800.1 4627903 4629285 D Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 4627903..4629285 Escherichia coli HS 5593965 YP_001461155.1 CDS nadR NC_009800.1 4629306 4630538 D catalyzes the formation of NAD(+) from nicotinamide ribonucleotide; nicotinamide-nucleotide adenylyltransferase 4629306..4630538 Escherichia coli HS 5593966 YP_001461156.1 CDS EcHS_A4626 NC_009800.1 4630589 4630738 D hypothetical protein 4630589..4630738 Escherichia coli HS 5593967 YP_001461157.1 CDS EcHS_A4627 NC_009800.1 4630845 4632512 R ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; ABC transporter ATP-binding protein complement(4630845..4632512) Escherichia coli HS 5591571 YP_001461158.1 CDS slt NC_009800.1 4632723 4634660 D catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan; lytic murein transglycosylase 4632723..4634660 Escherichia coli HS 5591572 YP_001461159.1 CDS trpR NC_009800.1 4634750 4635076 D When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription; Trp operon repressor 4634750..4635076 Escherichia coli HS 5591573 YP_001461160.1 CDS EcHS_A4630 NC_009800.1 4635119 4635640 R pyrophosphatase; has activity against dUTP and dITP; the crystal structure of the Vibrio protein showed similarity to Methanococcus janaschii Mj0226; in Vibrio cholerae this gene is part of the Mba operon that is involved in regulation and maintenance of biofilms; in Escherichia coli overexpression of this gene leads to resistance to an HMP analog; NTPase complement(4635119..4635640) Escherichia coli HS 5591574 YP_001461161.1 CDS EcHS_A4631 NC_009800.1 4635683 4636330 D catalyzes reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate; phosphoglycerate mutase 4635683..4636330 Escherichia coli HS 5594301 YP_001461162.1 CDS rob NC_009800.1 4636327 4637196 R identified by similarity to SP:P0ACI2; match to protein family HMM PF00165; match to protein family HMM PF06445; right origin-binding protein complement(4636327..4637196) Escherichia coli HS 5594302 YP_001461163.1 CDS EcHS_A4633 NC_009800.1 4637407 4637880 D identified by match to protein family HMM PF05981; hypothetical protein 4637407..4637880 Escherichia coli HS 5594303 YP_001461164.1 CDS creB NC_009800.1 4637893 4638582 D response regulator in two-component regulatory system with CreC; CreB protein is phosphorylated by sensor protein phospho-CreC; involved in catabolic regulation; DNA-binding response regulator CreB 4637893..4638582 Escherichia coli HS 5594304 YP_001461165.1 CDS creC NC_009800.1 4638582 4640006 D part of a two-component regulatory system with CreB or PhoB; involved in catabolic regulation; sensory histidine kinase CreC 4638582..4640006 Escherichia coli HS 5593349 YP_001461166.1 CDS EcHS_A4636 NC_009800.1 4640064 4641416 D identified by match to protein family HMM PF06123; hypothetical protein 4640064..4641416 Escherichia coli HS 5593350 YP_001461167.1 CDS arcA NC_009800.1 4641476 4642192 R identified by match to protein family HMM PF00072; match to protein family HMM PF00486; two-component response regulator complement(4641476..4642192) Escherichia coli HS 5593351 YP_001461168.1 CDS EcHS_A4638 NC_009800.1 4642288 4642428 D identified by similarity to GB:AAV80131.1; hypothetical protein 4642288..4642428 Escherichia coli HS 5593352 YP_001461169.1 CDS EcHS_A4639 NC_009800.1 4642828 4643514 D member of the SPOUT superfamily of methyltransferases; RNA methyltransferase 4642828..4643514 Escherichia coli HS 5594542 EcHS_A4641 tRNA EcHS_A4641 NC_009800.1 224770 224846 D tRNA-Ile 224770..224846 Escherichia coli HS 5591214 EcHS_A4642 tRNA EcHS_A4642 NC_009800.1 224888 224965 D tRNA-Ala 224888..224965 Escherichia coli HS 5595052 EcHS_A4643 tRNA EcHS_A4643 NC_009800.1 228305 228383 D tRNA-Asp 228305..228383 Escherichia coli HS 5592211 EcHS_A4644 tRNA EcHS_A4644 NC_009800.1 236529 236607 D tRNA-Asp 236529..236607 Escherichia coli HS 5595220 EcHS_A4645 tRNA EcHS_A4645 NC_009800.1 291741 291816 D tRNA-Thr 291741..291816 Escherichia coli HS 5593209 EcHS_A4646 tRNA EcHS_A4646 NC_009800.1 411322 411402 D tRNA-OTHER 411322..411402 Escherichia coli HS 5595267 EcHS_A4647 tRNA EcHS_A4647 NC_009800.1 624260 624338 D tRNA-Arg 624260..624338 Escherichia coli HS 5591427 EcHS_A4648 tRNA EcHS_A4648 NC_009800.1 725439 725515 R tRNA-Gln complement(725439..725515) Escherichia coli HS 5591472 EcHS_A4649 tRNA EcHS_A4649 NC_009800.1 725551 725627 R tRNA-Gln complement(725551..725627) Escherichia coli HS 5591473 EcHS_A4650 tRNA EcHS_A4650 NC_009800.1 725673 725751 R tRNA-Met complement(725673..725751) Escherichia coli HS 5592537 EcHS_A4651 tRNA EcHS_A4651 NC_009800.1 725765 725841 R tRNA-Gln complement(725765..725841) Escherichia coli HS 5594477 EcHS_A4652 tRNA EcHS_A4652 NC_009800.1 725875 725949 R tRNA-Gln complement(725875..725949) Escherichia coli HS 5594478 EcHS_A4653 tRNA EcHS_A4653 NC_009800.1 725972 726058 R tRNA-Leu complement(725972..726058) Escherichia coli HS 5594501 EcHS_A4654 tRNA EcHS_A4654 NC_009800.1 726065 726143 R tRNA-Met complement(726065..726143) Escherichia coli HS 5594994 EcHS_A4655 tRNA EcHS_A4655 NC_009800.1 807407 807484 D tRNA-Lys 807407..807484 Escherichia coli HS 5592006 EcHS_A4656 tRNA EcHS_A4656 NC_009800.1 807618 807695 D tRNA-Val 807618..807695 Escherichia coli HS 5592007 EcHS_A4657 tRNA EcHS_A4657 NC_009800.1 807697 807772 D tRNA-Lys 807697..807772 Escherichia coli HS 5591395 EcHS_A4658 tRNA EcHS_A4658 NC_009800.1 807824 807899 D tRNA-Val 807824..807899 Escherichia coli HS 5591396 EcHS_A4659 tRNA EcHS_A4659 NC_009800.1 807903 807978 D tRNA-Lys 807903..807978 Escherichia coli HS 5591336 EcHS_A4660 tRNA EcHS_A4660 NC_009800.1 808124 808201 D tRNA-Lys 808124..808201 Escherichia coli HS 5591739 EcHS_A4661 tRNA EcHS_A4661 NC_009800.1 808333 808408 D tRNA-Lys 808333..808408 Escherichia coli HS 5591740 EcHS_A4662 tRNA EcHS_A4662 NC_009800.1 986231 986320 R tRNA-Ser complement(986231..986320) Escherichia coli HS 5592940 EcHS_A4663 tRNA EcHS_A4663 NC_009800.1 1093238 1093327 R tRNA-Ser complement(1093238..1093327) Escherichia coli HS 5591704 EcHS_A4664 tRNA EcHS_A4664 NC_009800.1 1160460 1160549 R tRNA-Ser complement(1160460..1160549) Escherichia coli HS 5593233 EcHS_A4665 tRNA EcHS_A4665 NC_009800.1 1335326 1335412 R tRNA-Tyr complement(1335326..1335412) Escherichia coli HS 5593712 EcHS_A4666 tRNA EcHS_A4666 NC_009800.1 1335795 1335881 R tRNA-Tyr complement(1335795..1335881) Escherichia coli HS 5593713 EcHS_A4667 tRNA EcHS_A4667 NC_009800.1 1768458 1768536 D tRNA-Val 1768458..1768536 Escherichia coli HS 5592397 EcHS_A4668 tRNA EcHS_A4668 NC_009800.1 1768539 1768617 D tRNA-Val 1768539..1768617 Escherichia coli HS 5592398 EcHS_A4669 tRNA EcHS_A4669 NC_009800.1 2011442 2011528 R tRNA-Leu complement(2011442..2011528) Escherichia coli HS 5593526 EcHS_A4670 tRNA EcHS_A4670 NC_009800.1 2011541 2011614 R tRNA-Cys complement(2011541..2011614) Escherichia coli HS 5592679 EcHS_A4671 tRNA EcHS_A4671 NC_009800.1 2011669 2011744 R tRNA-Gly complement(2011669..2011744) Escherichia coli HS 5592680 EcHS_A4672 tRNA EcHS_A4672 NC_009800.1 2082069 2082160 R tRNA-Ser complement(2082069..2082160) Escherichia coli HS 5594226 EcHS_A4673 tRNA EcHS_A4673 NC_009800.1 2083150 2083227 D tRNA-Asn 2083150..2083227 Escherichia coli HS 5593946 EcHS_A4674 tRNA EcHS_A4674 NC_009800.1 2096629 2096706 R tRNA-Asn complement(2096629..2096706) Escherichia coli HS 5594611 EcHS_A4675 tRNA EcHS_A4675 NC_009800.1 2098453 2098530 D tRNA-Asn 2098453..2098530 Escherichia coli HS 5595385 EcHS_A4676 tRNA EcHS_A4676 NC_009800.1 2100861 2100938 D tRNA-Asn 2100861..2100938 Escherichia coli HS 5594688 EcHS_A4677 tRNA EcHS_A4677 NC_009800.1 2328388 2328466 D tRNA-Pro 2328388..2328466 Escherichia coli HS 5592009 EcHS_A4678 tRNA EcHS_A4678 NC_009800.1 2507928 2508004 D tRNA-Arg 2507928..2508004 Escherichia coli HS 5592309 EcHS_A4679 tRNA EcHS_A4679 NC_009800.1 2549442 2549519 R tRNA-Ala complement(2549442..2549519) Escherichia coli HS 5591863 EcHS_A4680 tRNA EcHS_A4680 NC_009800.1 2549558 2549633 R tRNA-Ala complement(2549558..2549633) Escherichia coli HS 5591864 EcHS_A4681 tRNA EcHS_A4681 NC_009800.1 2552333 2552408 D tRNA-Val 2552333..2552408 Escherichia coli HS 5594443 EcHS_A4682 tRNA EcHS_A4682 NC_009800.1 2552452 2552529 D tRNA-Val 2552452..2552529 Escherichia coli HS 5594444 EcHS_A4683 tRNA EcHS_A4683 NC_009800.1 2552574 2552651 D tRNA-Val 2552574..2552651 Escherichia coli HS 5590951 EcHS_A4684 tRNA EcHS_A4684 NC_009800.1 2552655 2552730 D tRNA-Lys 2552655..2552730 Escherichia coli HS 5591410 EcHS_A4686 tRNA EcHS_A4686 NC_009800.1 2768981 2769058 R tRNA-Glu complement(2768981..2769058) Escherichia coli HS 5593244 EcHS_A4687 tRNA EcHS_A4687 NC_009800.1 2803207 2803282 R tRNA-Met complement(2803207..2803282) Escherichia coli HS 5593751 EcHS_A4688 tRNA EcHS_A4688 NC_009800.1 2835200 2835278 R tRNA-Arg complement(2835200..2835278) Escherichia coli HS 5591728 EcHS_A4689 tRNA EcHS_A4689 NC_009800.1 2835475 2835553 R tRNA-Arg complement(2835475..2835553) Escherichia coli HS 5591729 EcHS_A4690 tRNA EcHS_A4690 NC_009800.1 2835614 2835692 R tRNA-Arg complement(2835614..2835692) Escherichia coli HS 5591578 EcHS_A4691 tRNA EcHS_A4691 NC_009800.1 2835889 2835967 R tRNA-Arg complement(2835889..2835967) Escherichia coli HS 5591579 EcHS_A4692 tRNA EcHS_A4692 NC_009800.1 2835969 2836063 R tRNA-Ser complement(2835969..2836063) Escherichia coli HS 5591282 EcHS_A4693 tRNA EcHS_A4693 NC_009800.1 2965596 2965672 D tRNA-Met 2965596..2965672 Escherichia coli HS 5594608 EcHS_A4694 tRNA EcHS_A4694 NC_009800.1 2965706 2965782 D tRNA-Met 2965706..2965782 Escherichia coli HS 5594609 EcHS_A4695 tRNA EcHS_A4695 NC_009800.1 2965816 2965892 D tRNA-Met 2965816..2965892 Escherichia coli HS 5595441 EcHS_A4696 tRNA EcHS_A4696 NC_009800.1 2965926 2966002 D tRNA-Met 2965926..2966002 Escherichia coli HS 5594624 EcHS_A4697 tRNA EcHS_A4697 NC_009800.1 3026497 3026572 R tRNA-Gly complement(3026497..3026572) Escherichia coli HS 5594659 EcHS_A4698 tRNA EcHS_A4698 NC_009800.1 3139284 3139361 D tRNA-Phe 3139284..3139361 Escherichia coli HS 5593854 EcHS_A4699 tRNA EcHS_A4699 NC_009800.1 3259042 3259119 D tRNA-Met 3259042..3259119 Escherichia coli HS 5592698 EcHS_A4700 tRNA EcHS_A4700 NC_009800.1 3369139 3369215 R tRNA-Met complement(3369139..3369215) Escherichia coli HS 5593110 EcHS_A4701 tRNA EcHS_A4701 NC_009800.1 3372997 3373085 R tRNA-Leu complement(3372997..3373085) Escherichia coli HS 5593357 EcHS_A4702 tRNA EcHS_A4702 NC_009800.1 3467922 3467999 R tRNA-Thr complement(3467922..3467999) Escherichia coli HS 5594593 EcHS_A4703 tRNA EcHS_A4703 NC_009800.1 3471300 3471377 R tRNA-Ala complement(3471300..3471377) Escherichia coli HS 5593295 EcHS_A4704 tRNA EcHS_A4704 NC_009800.1 3471419 3471495 R tRNA-Ile complement(3471419..3471495) Escherichia coli HS 5591990 EcHS_A4705 tRNA EcHS_A4705 NC_009800.1 3737918 3737996 R tRNA-Pro complement(3737918..3737996) Escherichia coli HS 5593677 EcHS_A4706 tRNA EcHS_A4706 NC_009800.1 3865805 3865899 D tRNA-Sec 3865805..3865899 Escherichia coli HS 5592799 EcHS_A4707 tRNA EcHS_A4707 NC_009800.1 3971845 3971922 D tRNA-Glu 3971845..3971922 Escherichia coli HS 5591022 EcHS_A4708 tRNA EcHS_A4708 NC_009800.1 3975282 3975360 D tRNA-Asp 3975282..3975360 Escherichia coli HS 5590963 EcHS_A4709 tRNA EcHS_A4709 NC_009800.1 3975367 3975444 D tRNA-Trp 3975367..3975444 Escherichia coli HS 5591172 EcHS_A4710 tRNA EcHS_A4710 NC_009800.1 4010788 4010864 D tRNA-Arg 4010788..4010864 Escherichia coli HS 5594977 EcHS_A4711 tRNA EcHS_A4711 NC_009800.1 4010922 4010999 D tRNA-His 4010922..4010999 Escherichia coli HS 5594978 EcHS_A4712 tRNA EcHS_A4712 NC_009800.1 4011018 4011106 D tRNA-Leu 4011018..4011106 Escherichia coli HS 5594979 EcHS_A4713 tRNA EcHS_A4713 NC_009800.1 4011147 4011225 D tRNA-Pro 4011147..4011225 Escherichia coli HS 5591981 EcHS_A4714 tRNA EcHS_A4714 NC_009800.1 4067399 4067475 D tRNA-Ile 4067399..4067475 Escherichia coli HS 5594757 EcHS_A4715 tRNA EcHS_A4715 NC_009800.1 4067517 4067594 D tRNA-Ala 4067517..4067594 Escherichia coli HS 5592179 EcHS_A4716 tRNA EcHS_A4716 NC_009800.1 4197952 4198029 D tRNA-Glu 4197952..4198029 Escherichia coli HS 5593605 EcHS_A4717 tRNA EcHS_A4717 NC_009800.1 4204969 4205046 D tRNA-Thr 4204969..4205046 Escherichia coli HS 5593142 EcHS_A4718 tRNA EcHS_A4718 NC_009800.1 4205054 4205138 D tRNA-Tyr 4205054..4205138 Escherichia coli HS 5593143 EcHS_A4719 tRNA EcHS_A4719 NC_009800.1 4205255 4205329 D tRNA-Gly 4205255..4205329 Escherichia coli HS 5592354 EcHS_A4720 tRNA EcHS_A4720 NC_009800.1 4205335 4205412 D tRNA-Thr 4205335..4205412 Escherichia coli HS 5594133 EcHS_A4721 tRNA EcHS_A4721 NC_009800.1 4239334 4239411 D tRNA-Glu 4239334..4239411 Escherichia coli HS 5592720 EcHS_A4722 tRNA EcHS_A4722 NC_009800.1 4386573 4386650 R tRNA-Phe complement(4386573..4386650) Escherichia coli HS 5590983 EcHS_A4723 tRNA EcHS_A4723 NC_009800.1 4417101 4417176 D tRNA-Gly 4417101..4417176 Escherichia coli HS 5594001 EcHS_A4724 tRNA EcHS_A4724 NC_009800.1 4417212 4417289 D tRNA-Gly 4417212..4417289 Escherichia coli HS 5594002 EcHS_A4725 tRNA EcHS_A4725 NC_009800.1 4417323 4417400 D tRNA-Gly 4417323..4417400 Escherichia coli HS 5592519 EcHS_A4726 tRNA EcHS_A4726 NC_009800.1 4532533 4532619 D tRNA-Leu 4532533..4532619 Escherichia coli HS 5591570 EcHS_A4727 tRNA EcHS_A4727 NC_009800.1 4609393 4609481 R tRNA-Leu complement(4609393..4609481) Escherichia coli HS 5593411 EcHS_A4728 tRNA EcHS_A4728 NC_009800.1 4609515 4609601 R tRNA-Leu complement(4609515..4609601) Escherichia coli HS 5594131 EcHS_A4729 tRNA EcHS_A4729 NC_009800.1 4609629 4609717 R tRNA-Leu complement(4609629..4609717) Escherichia coli HS 5594132 EcHS_A4732 rRNA rrs NC_009800.1 223160 224701 D 16S ribosomal RNA 223160..224701 Escherichia coli HS 5591213 EcHS_A4733 rRNA rrl NC_009800.1 225139 228041 D 23S ribosomal RNA 225139..228041 Escherichia coli HS 5592758 EcHS_A4734 rRNA rrf NC_009800.1 228136 228251 D 5S ribosomal RNA 228136..228251 Escherichia coli HS 5592759 EcHS_A4761 rRNA rrf NC_009800.1 2765684 2765799 R 5S ribosomal RNA complement(2765684..2765799) Escherichia coli HS 5593148 EcHS_A4762 rRNA rrl NC_009800.1 2765894 2768797 R 23S ribosomal RNA complement(2765894..2768797) Escherichia coli HS 5593149 EcHS_A4763 rRNA rrs NC_009800.1 2769229 2770770 R 16S ribosomal RNA complement(2769229..2770770) Escherichia coli HS 5593245 EcHS_A4782 rRNA rrf NC_009800.1 3467768 3467883 R 5S ribosomal RNA complement(3467768..3467883) Escherichia coli HS 5591316 EcHS_A4783 rRNA rrf NC_009800.1 3468013 3468128 R 5S ribosomal RNA complement(3468013..3468128) Escherichia coli HS 5594594 EcHS_A4784 rRNA rrl NC_009800.1 3468223 3471126 R 23S ribosomal RNA complement(3468223..3471126) Escherichia coli HS 5593294 EcHS_A4785 rRNA rrs NC_009800.1 3471564 3473105 R 16S ribosomal RNA complement(3471564..3473105) Escherichia coli HS 5591991 EcHS_A4789 rRNA rrs NC_009800.1 3970219 3971760 D 16S ribosomal RNA 3970219..3971760 Escherichia coli HS 5591021 EcHS_A4790 rRNA rrl NC_009800.1 3972115 3975018 D 23S ribosomal RNA 3972115..3975018 Escherichia coli HS 5591023 EcHS_A4791 rRNA rrf NC_009800.1 3975113 3975228 D 5S ribosomal RNA 3975113..3975228 Escherichia coli HS 5590962 EcHS_A4793 rRNA rrs NC_009800.1 4065789 4067330 D 16S ribosomal RNA 4065789..4067330 Escherichia coli HS 5594756 EcHS_A4794 rRNA rrl NC_009800.1 4067777 4070680 D 23S ribosomal RNA 4067777..4070680 Escherichia coli HS 5592180 EcHS_A4795 rRNA rrf NC_009800.1 4070869 4070984 D 5S ribosomal RNA 4070869..4070984 Escherichia coli HS 5591619 EcHS_A4800 rRNA rrs NC_009800.1 4196325 4197867 D 16S ribosomal RNA 4196325..4197867 Escherichia coli HS 5593604 EcHS_A4801 rRNA rrl NC_009800.1 4198222 4201125 D 23S ribosomal RNA 4198222..4201125 Escherichia coli HS 5590915 EcHS_A4802 rRNA rrf NC_009800.1 4201221 4201336 D 5S ribosomal RNA 4201221..4201336 Escherichia coli HS 5594193 EcHS_A4805 rRNA rrs NC_009800.1 4237708 4239249 D 16S ribosomal RNA 4237708..4239249 Escherichia coli HS 5592719 EcHS_A4806 rRNA rrl NC_009800.1 4239604 4242507 D 23S ribosomal RNA 4239604..4242507 Escherichia coli HS 5592721 EcHS_A4807 rRNA rrf NC_009800.1 4242603 4242718 D 5S ribosomal RNA 4242603..4242718 Escherichia coli HS 5591183